format-version: 1.2 data-version: releases/2015-08-11 date: 11:08:2015 15:26 saved-by: midori auto-generated-by: OBO-Edit 2.3.1 subsetdef: abnormal_slim "Abnormal/normal slim" subsetdef: absent_slim "Absent/present slim" subsetdef: attribute_slim "Attribute slim" subsetdef: biosapiens "biosapiens protein feature ontology" subsetdef: cell_quality "cell_quality" subsetdef: DBVAR "database of genomic structural variation" subsetdef: disposition_slim "Disposition slim" subsetdef: goantislim_grouping "Grouping classes that can be excluded" subsetdef: gocheck_do_not_annotate "Term not to be used for direct annotation" subsetdef: gocheck_do_not_manually_annotate "Term not to be used for direct manual annotation" subsetdef: goslim_aspergillus "Aspergillus GO slim" subsetdef: goslim_candida "Candida GO slim" subsetdef: goslim_chembl "ChEMBL protein targets summary" subsetdef: goslim_generic "Generic GO slim" subsetdef: goslim_goa "GOA and proteome slim" subsetdef: goslim_metagenomics "Metagenomics GO slim" subsetdef: goslim_pir "PIR GO slim" subsetdef: goslim_plant "Plant GO slim" subsetdef: goslim_pombe "Fission yeast GO slim" subsetdef: goslim_synapse "synapse GO slim" subsetdef: goslim_virus "Viral GO slim" subsetdef: goslim_yeast "Yeast GO slim" subsetdef: gosubset_prok "Prokaryotic GO subset" subsetdef: hpo_slim "Human phenotype slim" subsetdef: mf_needs_review "Catalytic activity terms in need of attention" subsetdef: mpath_slim "Pathology slim" subsetdef: qc_do_not_annotate "Term not to be used for direct annotation" subsetdef: qc_do_not_manually_annotate "Term not to be used for direct manual annotation" subsetdef: relational_slim "Relational slim: types of quality that require an additional entity in order to exist" subsetdef: scalar_slim "Scalar slim" subsetdef: SOFA "SO feature annotation" subsetdef: termgenie_unvetted "Terms created by TermGenie that do not follow a template and require additional vetting by editors" subsetdef: ubprop:upper_level "abstract upper-level terms not directly useful for analysis" subsetdef: value_slim "Value slim" subsetdef: virus_checked "Viral overhaul terms" synonymtypedef: aa1 "amino acid 1 letter code" synonymtypedef: aa3 "amino acid 3 letter code" synonymtypedef: AAMOD "amino acid modification" synonymtypedef: BRAND_NAME "BRAND NAME" synonymtypedef: BS "biosapiens" synonymtypedef: dbsnp "dbsnp variant terms" synonymtypedef: dbvar "DBVAR" synonymtypedef: ebi_variants "ensembl variant terms" synonymtypedef: FORMULA "FORMULA" synonymtypedef: GE "LANGUAGE GERMAN" synonymtypedef: HUMAN_PREFERRED "preferred term when talking about an instance of this class in Homo sapiens" synonymtypedef: InChI "InChI" synonymtypedef: InChIKey "InChIKey" synonymtypedef: INN "INN" synonymtypedef: IUPAC_NAME "IUPAC NAME" synonymtypedef: LATIN "latin term" synonymtypedef: PLURAL "plural term" synonymtypedef: RNAMOD "RNA modification" EXACT synonymtypedef: SCI "SCIENTIFIC NAME" synonymtypedef: SMILES "SMILES" synonymtypedef: systematic_synonym "Systematic synonym" EXACT synonymtypedef: VAR "variant annotation term" default-namespace: fission_yeast_phenotype remark: svn version: $Revision: 303 $ ontology: fypo [Term] id: BTO:0000316 name: culture medium namespace: BrendaTissueOBO def: "A substance, either solid or liquid, used for the cultivation, isolation, identification, or storage of microorganisms." [Biology-Online_Dictionary:http\://www.biology-online.org/dictionary/] synonym: "growth medium" RELATED [] synonym: "medium" RELATED [] synonym: "nutrient medium" RELATED [] property_value: IAO:0000412 http://purl.obolibrary.org/obo/TEMP [Term] id: CHEBI:10106 name: zearalenone namespace: chebi_ontology def: "A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species." [] synonym: "(-)-Zearalenone" RELATED [ChemIDplus:] synonym: "(10S)-Zearalenone" RELATED [ChemIDplus:] synonym: "(3S,11E)-14,16-dihydroxy-3-methyl-3,4,5,6,9,10-hexahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione" EXACT IUPAC_NAME [IUPAC:] synonym: "(S)-(-)-Zearalenone" RELATED [ChemIDplus:] synonym: "(S)-Zearalenone" RELATED [ChemIDplus:] synonym: "(S-(E))-3,4,5,6,9,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione" RELATED [ChemIDplus:] synonym: "6-(10-Hydroxy-6-oxo-trans-1-undecenyl)-beta-resorcylic acid lactone" RELATED [ChemIDplus:] synonym: "C18H22O5" RELATED FORMULA [ChEBI:] synonym: "C[C@H]1CCCC(=O)CCC\\C=C\\c2cc(O)cc(O)c2C(=O)O1" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C18H22O5/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12/h3,7,10-12,20-21H,2,4-6,8-9H2,1H3/b7-3+/t12-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=MBMQEIFVQACCCH-QBODLPLBSA-N" RELATED InChIKey [ChEBI:] synonym: "trans-Zearalenone" RELATED [ChemIDplus:] synonym: "Zearalenone" EXACT [KEGG COMPOUND:] xref: ChemIDplus:17924-92-4 "CAS Registry Number" xref: CiteXplore:17339071 "PubMed citation" xref: CiteXplore:18027362 "PubMed citation" xref: CiteXplore:18221829 "PubMed citation" xref: CiteXplore:18280460 "PubMed citation" xref: CiteXplore:18692541 "PubMed citation" xref: CiteXplore:20654554 "PubMed citation" xref: KEGG COMPOUND:17924-92-4 "CAS Registry Number" xref: KEGG COMPOUND:C09981 "KEGG COMPOUND" xref: KNApSAcK:C00003025 "KNApSAcK" xref: LIPID MAPS:LMPK04000016 "LIPID MAPS instance" xref: Reaxys:4875541 "Reaxys Registry Number" is_a: CHEBI:25106 ! macrolide is_a: CHEBI:33572 ! resorcinols property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:10986 name: (R)-4'-phosphonatopantothenate(3-) namespace: chebi_ontology def: "An organophosphate oxoanion that is the trianion of (R)-5-phosphopantothenic acid arising from deprotonation of the carboxy and phosphate OH groups; major species at pH 7.3" [] synonym: "(R)-4'-phosphopantothenate" RELATED [UniProt:] synonym: "3-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonatooxy)butanamido]propanoate" EXACT IUPAC_NAME [IUPAC:] synonym: "C9H15NO8P" RELATED FORMULA [ChEBI:] synonym: "CC(C)(COP([O-])([O-])=O)[C@@H](O)C(=O)NCCC([O-])=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C9H18NO8P/c1-9(2,5-18-19(15,16)17)7(13)8(14)10-4-3-6(11)12/h7,13H,3-5H2,1-2H3,(H,10,14)(H,11,12)(H2,15,16,17)/p-3/t7-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=XHFVGHPGDLDEQO-ZETCQYMHSA-K" RELATED InChIKey [ChEBI:] is_a: CHEBI:58945 ! organophosphate oxoanion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:12164 name: 5-phosphoribosyl diphosphate namespace: chebi_ontology synonym: "5-phosphoribosyl diphosphate" EXACT [UniProt:] is_a: CHEBI:21080 ! ribose diphosphate is_a: CHEBI:35158 ! ribose bisphosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:12936 name: D-galactose namespace: chebi_ontology synonym: "C6H12O6" RELATED FORMULA [ChEBI:] synonym: "D-Gal" RELATED [JCBN:] synonym: "D-galacto-hexose" EXACT IUPAC_NAME [IUPAC:] synonym: "D-galactose" EXACT IUPAC_NAME [IUPAC:] is_a: CHEBI:17608 ! D-aldohexose is_a: CHEBI:28260 ! galactose property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:13643 name: glycol namespace: chebi_ontology def: "A diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent." [] synonym: "a glycol" RELATED [UniProt:] synonym: "glycols" EXACT IUPAC_NAME [IUPAC:] synonym: "Glykol" RELATED [ChEBI:] is_a: CHEBI:23824 ! diol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:15075 name: selenate namespace: chebi_ontology def: "A divalent inorganic anion obtained by removal of both protons from selenic acid." [] synonym: "[O-][Se]([O-])(=O)=O" RELATED SMILES [ChEBI:] synonym: "[SeO4](2-)" RELATED [IUPAC:] synonym: "InChI=1S/H2O4Se/c1-5(2,3)4/h(H2,1,2,3,4)/p-2" RELATED InChI [ChEBI:] synonym: "InChIKey=QYHFIVBSNOWOCQ-UHFFFAOYSA-L" RELATED InChIKey [ChEBI:] synonym: "O4Se" RELATED FORMULA [ChEBI:] synonym: "Selenate" EXACT [ChemIDplus:] synonym: "selenate" EXACT IUPAC_NAME [IUPAC:] synonym: "selenate" EXACT [UniProt:] synonym: "SELENATE ION" RELATED [PDBeChem:] synonym: "tetraoxidoselenate(2-)" EXACT IUPAC_NAME [IUPAC:] xref: ChemIDplus:14124-68-6 "CAS Registry Number" xref: PDBeChem:SE4 "PDBeChem" is_a: CHEBI:33488 ! selenium oxoanion is_a: CHEBI:79388 ! divalent inorganic anion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:15138 name: sulfide(2-) namespace: chebi_ontology def: "A divalent inorganic anion obtained by removal of both protons from hydrogen sulfide." [] synonym: "[S--]" RELATED SMILES [ChEBI:] synonym: "InChI=1S/S/q-2" RELATED InChI [ChEBI:] synonym: "InChIKey=UCKMPCXJQFINFW-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "S" RELATED FORMULA [ChEBI:] synonym: "S(2-)" RELATED [IUPAC:] synonym: "sulfanediide" EXACT IUPAC_NAME [IUPAC:] synonym: "Sulfide" RELATED [ChemIDplus:] synonym: "sulfide" RELATED [UniProt:] synonym: "sulfide(2-)" EXACT IUPAC_NAME [IUPAC:] synonym: "sulphide" RELATED [ChEBI:] xref: ChemIDplus:18496-25-8 "CAS Registry Number" xref: UM-BBD:c0569 "UM-BBD compID" is_a: CHEBI:79388 ! divalent inorganic anion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:15354 name: choline namespace: chebi_ontology alt_id: CHEBI:13985 alt_id: CHEBI:23212 alt_id: CHEBI:3665 alt_id: CHEBI:41524 def: "A choline that is the parent compound of the cholines class, consisting of ethanolamine having three methyl substituents attached to the amino function." [] synonym: "2-hydroxy-N,N,N-trimethylethanaminium" EXACT IUPAC_NAME [IUPAC:] synonym: "Bilineurine" RELATED [KEGG COMPOUND:] synonym: "C5H14NO" RELATED FORMULA [ChEBI:] synonym: "C[N+](C)(C)CCO" RELATED SMILES [ChEBI:] synonym: "Choline" EXACT [KEGG COMPOUND:] synonym: "choline" EXACT [UniProt:] synonym: "CHOLINE ION" RELATED [PDBeChem:] synonym: "InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1" RELATED InChI [ChEBI:] synonym: "InChIKey=OEYIOHPDSNJKLS-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "N,N,N-trimethylethanol-ammonium" RELATED [ChEBI:] synonym: "N-trimethylethanolamine" RELATED [ChEBI:] synonym: "trimethylethanolamine" RELATED [ChEBI:] xref: Beilstein:1736748 "Beilstein Registry Number" xref: ChemIDplus:62-49-7 "CAS Registry Number" xref: CiteXplore:10930630 "PubMed citation" xref: CiteXplore:12826235 "PubMed citation" xref: CiteXplore:12946691 "PubMed citation" xref: CiteXplore:14972364 "PubMed citation" xref: CiteXplore:16210714 "PubMed citation" xref: CiteXplore:17087106 "PubMed citation" xref: CiteXplore:17283071 "PubMed citation" xref: CiteXplore:17344490 "PubMed citation" xref: CiteXplore:18204095 "PubMed citation" xref: CiteXplore:18230680 "PubMed citation" xref: CiteXplore:18786517 "PubMed citation" xref: CiteXplore:18786520 "PubMed citation" xref: CiteXplore:19246089 "PubMed citation" xref: CiteXplore:20038853 "PubMed citation" xref: CiteXplore:20446114 "PubMed citation" xref: CiteXplore:22770225 "PubMed citation" xref: CiteXplore:22961562 "PubMed citation" xref: CiteXplore:23095202 "PubMed citation" xref: CiteXplore:23616508 "PubMed citation" xref: CiteXplore:23637565 "PubMed citation" xref: CiteXplore:23733158 "PubMed citation" xref: CiteXplore:6420466 "PubMed citation" xref: CiteXplore:7590654 "PubMed citation" xref: CiteXplore:9517478 "PubMed citation" xref: DrugBank:DB00122 "DrugBank" xref: ECMDB:ECMDB00097 "ECMDB" xref: Gmelin:324597 "Gmelin Registry Number" xref: HMDB:HMDB00097 "HMDB" xref: KEGG COMPOUND:62-49-7 "CAS Registry Number" xref: KEGG COMPOUND:C00114 "KEGG COMPOUND" xref: KEGG DRUG:D07690 "KEGG DRUG" xref: KNApSAcK:C00007298 "KNApSAcK" xref: MetaCyc:CHOLINE "MetaCyc" xref: PDBeChem:CHT "PDBeChem" xref: Reaxys:1736748 "Reaxys Registry Number" xref: Wikipedia:Choline "Wikipedia" xref: YMDB:YMDB00227 "YMDB" is_a: CHEBI:23217 ! cholines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:15356 name: cysteine namespace: chebi_ontology alt_id: CHEBI:14061 alt_id: CHEBI:23508 alt_id: CHEBI:4050 def: "A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3." [] synonym: "2-amino-3-mercaptopropanoic acid" RELATED [JCBN:] synonym: "2-Amino-3-mercaptopropionic acid" RELATED [KEGG COMPOUND:] synonym: "2-amino-3-sulfanylpropanoic acid" RELATED [IUPAC:] synonym: "C" RELATED [ChEBI:] synonym: "C3H7NO2S" RELATED FORMULA [KEGG COMPOUND:] synonym: "cisteina" RELATED [ChEBI:] synonym: "Cys" RELATED [ChEBI:] synonym: "Cystein" RELATED [ChEBI:] synonym: "Cysteine" EXACT [KEGG COMPOUND:] synonym: "cysteine" EXACT [ChEBI:] synonym: "cysteine" EXACT IUPAC_NAME [IUPAC:] synonym: "Hcys" RELATED [IUPAC:] synonym: "InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)" RELATED InChI [ChEBI:] synonym: "InChIKey=XUJNEKJLAYXESH-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "NC(CS)C(O)=O" RELATED SMILES [ChEBI:] synonym: "Zystein" RELATED [ChEBI:] xref: Beilstein:1721406 "Beilstein Registry Number" xref: ChemIDplus:3374-22-9 "CAS Registry Number" xref: CiteXplore:17439666 "PubMed citation" xref: CiteXplore:25181601 "PubMed citation" xref: Gmelin:2933 "Gmelin Registry Number" xref: KEGG COMPOUND:3374-22-9 "CAS Registry Number" xref: KEGG COMPOUND:C00736 "KEGG COMPOUND" xref: KNApSAcK:C00001351 "KNApSAcK" xref: KNApSAcK:C00007323 "KNApSAcK" xref: NIST Chemistry WebBook:3374-22-9 "CAS Registry Number" xref: Reaxys:1721406 "Reaxys Registry Number" xref: Wikipedia:Cysteine "Wikipedia" is_a: CHEBI:26834 ! sulfur-containing amino acid is_a: CHEBI:33704 ! alpha-amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:15369 name: actinomycin namespace: chebi_ontology alt_id: CHEBI:13723 alt_id: CHEBI:22220 alt_id: CHEBI:2445 def: "A large group of antibiotics isolated from various species of Streptomyces and characterised by having a substituted phenoxazine ring linked to two cyclic heterodetic peptides." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "Actinomycin" EXACT [KEGG COMPOUND:] synonym: "actinomycin" EXACT [UniProt:] synonym: "actinomycins" RELATED [ChEBI:] xref: ChemIDplus:1402-38-6 "CAS Registry Number" xref: KEGG COMPOUND:1402-38-6 "CAS Registry Number" xref: KEGG COMPOUND:C01775 "KEGG COMPOUND" is_a: CHEBI:23239 ! chromopeptide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:15414 name: S-adenosyl-L-methionine namespace: chebi_ontology alt_id: CHEBI:10786 alt_id: CHEBI:10833 alt_id: CHEBI:12742 alt_id: CHEBI:12757 alt_id: CHEBI:12760 alt_id: CHEBI:22036 alt_id: CHEBI:45607 alt_id: CHEBI:527887 alt_id: CHEBI:8946 def: "A sulfonium compound that is the S-adenosyl derivative of L-methionine. It is an intermediate in the metabolic pathway of methionine." [] synonym: "(2S)-2-amino-4-[{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}(methyl)sulfonio]butanoate (non-preferred name)" RELATED [PDBeChem:] synonym: "(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner salt" RELATED [ChemIDplus:] synonym: "[(3S)-3-amino-3-carboxypropyl](5'-deoxyadenosin-5'-yl)(methyl)sulfonium" EXACT IUPAC_NAME [IUPAC:] synonym: "[1-(adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium" RELATED [IUPAC:] synonym: "Acylcarnitine" RELATED [KEGG COMPOUND:] synonym: "AdoMet" RELATED [JCBN:] synonym: "C15H23N6O5S" RELATED FORMULA [ChEBI:] synonym: "C15H23N6O5S" RELATED FORMULA [KEGG COMPOUND:] synonym: "C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8+,10+,11+,14+,27?/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=MEFKEPWMEQBLKI-AIRLBKTGSA-O" RELATED InChIKey [ChEBI:] synonym: "S-(5'-deoxyadenosin-5'-yl)-L-methionine" RELATED [JCBN:] synonym: "S-Adenosyl-L-methionine" EXACT [KEGG COMPOUND:] synonym: "S-adenosyl-L-methionine" EXACT [ChEBI:] synonym: "S-adenosyl-L-methionine(1+)" RELATED [UniProt:] synonym: "S-ADENOSYLMETHIONINE" RELATED [PDBeChem:] synonym: "S-Adenosylmethionine" RELATED [KEGG COMPOUND:] synonym: "S-adenosylmethionine" RELATED [ChEBI:] synonym: "SAM" RELATED [JCBN:] synonym: "SAMe" RELATED [ChemIDplus:] xref: Beilstein:3576439 "Beilstein Registry Number" xref: ChemIDplus:29908-03-0 "CAS Registry Number" xref: CiteXplore:11017945 "PubMed citation" xref: CiteXplore:17439666 "PubMed citation" xref: COMe:MOL000172 "COMe" xref: DrugBank:DB00118 "DrugBank" xref: HMDB:HMDB01185 "HMDB" xref: KEGG COMPOUND:29908-03-0 "CAS Registry Number" xref: KEGG COMPOUND:C00019 "KEGG COMPOUND" xref: MetaCyc:S-ADENOSYLMETHIONINE "MetaCyc" xref: Reaxys:3919754 "Reaxys Registry Number" xref: Wikipedia:S-Adenosyl_methionine "Wikipedia" is_a: CHEBI:26830 ! sulfonium compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:15428 name: glycine namespace: chebi_ontology alt_id: CHEBI:10792 alt_id: CHEBI:14344 alt_id: CHEBI:24368 alt_id: CHEBI:42964 alt_id: CHEBI:5460 def: "The simplest (and the only achiral) proteinogenic amino acid, with a hydrogen atom as its side chain." [] synonym: "Aminoacetic acid" RELATED [KEGG COMPOUND:] synonym: "aminoacetic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "Aminoessigsaeure" RELATED [ChEBI:] synonym: "aminoethanoic acid" RELATED [ChEBI:] synonym: "aminoethanoic acid" RELATED [JCBN:] synonym: "C2H5NO2" RELATED FORMULA [KEGG COMPOUND:] synonym: "G" RELATED [ChEBI:] synonym: "Gly" RELATED [KEGG COMPOUND:] synonym: "Glycin" RELATED [ChemIDplus:] synonym: "GLYCINE" EXACT [PDBeChem:] synonym: "Glycine" EXACT [KEGG COMPOUND:] synonym: "glycine" EXACT IUPAC_NAME [IUPAC:] synonym: "Glycocoll" RELATED [ChemIDplus:] synonym: "Glykokoll" RELATED [ChEBI:] synonym: "Glyzin" RELATED [ChEBI:] synonym: "H2N-CH2-COOH" RELATED [IUPAC:] synonym: "Hgly" RELATED [IUPAC:] synonym: "InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)" RELATED InChI [ChEBI:] synonym: "InChIKey=DHMQDGOQFOQNFH-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "Leimzucker" RELATED [ChemIDplus:] synonym: "NCC(O)=O" RELATED SMILES [ChEBI:] xref: Beilstein:635782 "Beilstein Registry Number" xref: ChemIDplus:56-40-6 "CAS Registry Number" xref: CiteXplore:10930630 "PubMed citation" xref: CiteXplore:11019925 "PubMed citation" xref: CiteXplore:11174716 "PubMed citation" xref: CiteXplore:11542461 "PubMed citation" xref: CiteXplore:11806864 "PubMed citation" xref: CiteXplore:12631515 "PubMed citation" xref: CiteXplore:12754315 "PubMed citation" xref: CiteXplore:12770151 "PubMed citation" xref: CiteXplore:12921899 "PubMed citation" xref: CiteXplore:15331688 "PubMed citation" xref: CiteXplore:15388434 "PubMed citation" xref: CiteXplore:15710237 "PubMed citation" xref: CiteXplore:16105183 "PubMed citation" xref: CiteXplore:16151895 "PubMed citation" xref: CiteXplore:16214212 "PubMed citation" xref: CiteXplore:16417482 "PubMed citation" xref: CiteXplore:16444815 "PubMed citation" xref: CiteXplore:16664855 "PubMed citation" xref: CiteXplore:16901953 "PubMed citation" xref: CiteXplore:16918424 "PubMed citation" xref: CiteXplore:16986325 "PubMed citation" xref: CiteXplore:16998855 "PubMed citation" xref: CiteXplore:17154252 "PubMed citation" xref: CiteXplore:17383967 "PubMed citation" xref: CiteXplore:17582620 "PubMed citation" xref: CiteXplore:17970719 "PubMed citation" xref: CiteXplore:18079355 "PubMed citation" xref: CiteXplore:18396796 "PubMed citation" xref: CiteXplore:18440992 "PubMed citation" xref: CiteXplore:18593588 "PubMed citation" xref: CiteXplore:18816054 "PubMed citation" xref: CiteXplore:18840508 "PubMed citation" xref: CiteXplore:19028609 "PubMed citation" xref: CiteXplore:19120667 "PubMed citation" xref: CiteXplore:19449910 "PubMed citation" xref: CiteXplore:19526731 "PubMed citation" xref: CiteXplore:19544666 "PubMed citation" xref: CiteXplore:19738917 "PubMed citation" xref: CiteXplore:19916621 "PubMed citation" xref: CiteXplore:19924257 "PubMed citation" xref: CiteXplore:21751272 "PubMed citation" xref: CiteXplore:22044190 "PubMed citation" xref: CiteXplore:22079563 "PubMed citation" xref: CiteXplore:22234938 "PubMed citation" xref: CiteXplore:22264337 "PubMed citation" xref: CiteXplore:22293292 "PubMed citation" xref: CiteXplore:22401276 "PubMed citation" xref: CiteXplore:22434786 "PubMed citation" xref: DrugBank:DB00145 "DrugBank" xref: ECMDB:ECMDB00123 "ECMDB" xref: Gmelin:1808 "Gmelin Registry Number" xref: HMDB:HMDB00123 "HMDB" xref: KEGG COMPOUND:56-40-6 "CAS Registry Number" xref: KEGG COMPOUND:C00037 "KEGG COMPOUND" xref: KEGG DRUG:D00011 "KEGG DRUG" xref: KNApSAcK:C00001361 "KNApSAcK" xref: MetaCyc:GLY "MetaCyc" xref: NIST Chemistry WebBook:56-40-6 "CAS Registry Number" xref: PDBeChem:GLY "PDBeChem" xref: Reaxys:635782 "Reaxys Registry Number" xref: Wikipedia:Glycine "Wikipedia" xref: YMDB:YMDB00016 "YMDB" is_a: CHEBI:26650 ! serine family amino acid is_a: CHEBI:83813 ! proteinogenic amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:15440 name: squalene namespace: chebi_ontology alt_id: CHEBI:10795 alt_id: CHEBI:10843 alt_id: CHEBI:15104 alt_id: CHEBI:26746 alt_id: CHEBI:9245 def: "A triterpene consisting of 2,6,10,15,19,23-hexamethyltetracosane having six double bonds at the 2-, 6-, 10-, 14-, 18- and 22-positions with (all-E)-configuration." [] synonym: "(6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene" EXACT IUPAC_NAME [IUPAC:] synonym: "(all-E)-2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene" RELATED [NIST Chemistry WebBook:] synonym: "C30H50" RELATED FORMULA [ChEBI:] synonym: "CC(C)=CCC\\C(C)=C\\CC\\C(C)=C\\CC\\C=C(/C)CC\\C=C(/C)CCC=C(C)C" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+" RELATED InChI [ChEBI:] synonym: "InChIKey=YYGNTYWPHWGJRM-AAJYLUCBSA-N" RELATED InChIKey [ChEBI:] synonym: "Spinacene" RELATED [KEGG COMPOUND:] synonym: "Squalene" EXACT [KEGG COMPOUND:] synonym: "squalene" EXACT [UniProt:] synonym: "Supraene" RELATED [KEGG COMPOUND:] xref: Beilstein:1728920 "Beilstein Registry Number" xref: ChemIDplus:111-02-4 "CAS Registry Number" xref: CiteXplore:16341241 "PubMed citation" xref: CiteXplore:21973054 "PubMed citation" xref: CiteXplore:24362891 "PubMed citation" xref: KEGG COMPOUND:111-02-4 "CAS Registry Number" xref: KEGG COMPOUND:C00751 "KEGG COMPOUND" xref: KNApSAcK:C00003755 "KNApSAcK" xref: LIPID MAPS:LMPR0106010002 "LIPID MAPS instance" xref: NIST Chemistry WebBook:111-02-4 "CAS Registry Number" is_a: CHEBI:35191 ! triterpene property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:15603 name: L-leucine namespace: chebi_ontology alt_id: CHEBI:10866 alt_id: CHEBI:13131 alt_id: CHEBI:21348 alt_id: CHEBI:43646 alt_id: CHEBI:43695 alt_id: CHEBI:43733 alt_id: CHEBI:43814 alt_id: CHEBI:6260 def: "The L-enantiomer of leucine." [] synonym: "(2S)-2-amino-4-methylpentanoic acid" RELATED [IUPAC:] synonym: "(2S)-alpha-2-Amino-4-methylvaleric acid" RELATED [KEGG COMPOUND:] synonym: "(2S)-alpha-Leucine" RELATED [KEGG COMPOUND:] synonym: "(S)-(+)-leucine" RELATED [NIST Chemistry WebBook:] synonym: "(S)-leucine" RELATED [NIST Chemistry WebBook:] synonym: "2-Amino-4-methylvaleric acid" RELATED [KEGG COMPOUND:] synonym: "C6H13NO2" RELATED FORMULA [KEGG COMPOUND:] synonym: "CC(C)C[C@H](N)C(O)=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=ROHFNLRQFUQHCH-YFKPBYRVSA-N" RELATED InChIKey [ChEBI:] synonym: "L" RELATED [ChEBI:] synonym: "L-Leucin" RELATED [ChEBI:] synonym: "L-Leucine" EXACT [KEGG COMPOUND:] synonym: "L-leucine" EXACT IUPAC_NAME [IUPAC:] synonym: "L-Leuzin" RELATED [ChEBI:] synonym: "Leu" RELATED [ChEBI:] synonym: "LEUCINE" RELATED [PDBeChem:] xref: Beilstein:1721722 "Beilstein Registry Number" xref: ChemIDplus:61-90-5 "CAS Registry Number" xref: CiteXplore:17609475 "PubMed citation" xref: CiteXplore:22735334 "PubMed citation" xref: CiteXplore:24206068 "PubMed citation" xref: CiteXplore:24333966 "PubMed citation" xref: CiteXplore:8798704 "PubMed citation" xref: DrugBank:DB00149 "DrugBank" xref: ECMDB:ECMDB00687 "ECMDB" xref: Gmelin:50204 "Gmelin Registry Number" xref: HMDB:HMDB00687 "HMDB" xref: KEGG COMPOUND:61-90-5 "CAS Registry Number" xref: KEGG COMPOUND:C00123 "KEGG COMPOUND" xref: KEGG DRUG:D00030 "KEGG DRUG" xref: KNApSAcK:C00001377 "KNApSAcK" xref: MetaCyc:LEU "MetaCyc" xref: NIST Chemistry WebBook:61-90-5 "CAS Registry Number" xref: PDBeChem:LEU_LFOH "PDBeChem" xref: Reaxys:1721722 "Reaxys Registry Number" xref: Wikipedia:Leucine "Wikipedia" xref: YMDB:YMDB00387 "YMDB" is_a: CHEBI:25017 ! leucine is_a: CHEBI:26463 ! pyruvate family amino acid is_a: CHEBI:83813 ! proteinogenic amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:15693 name: aldose namespace: chebi_ontology alt_id: CHEBI:13755 alt_id: CHEBI:22305 alt_id: CHEBI:2561 def: "Aldehydic parent sugars (polyhydroxy aldehydes H[CH(OH)]nC(=O)H, n >= 2) and their intramolecular hemiacetals." [] synonym: "Aldose" EXACT [KEGG COMPOUND:] synonym: "aldoses" RELATED [ChEBI:] synonym: "an aldose" RELATED [UniProt:] synonym: "C2H4O2(CH2O)n" RELATED FORMULA [ChEBI:] xref: KEGG COMPOUND:C01370 "KEGG COMPOUND" xref: Wikipedia:Aldose "Wikipedia" is_a: CHEBI:35381 ! monosaccharide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:15705 name: L-alpha-amino acid namespace: chebi_ontology alt_id: CHEBI:13072 alt_id: CHEBI:13243 alt_id: CHEBI:13797 alt_id: CHEBI:21224 alt_id: CHEBI:6175 def: "Any alpha-amino acid having L-configuration at the alpha-carbon." [] synonym: "C2H4NO2R" RELATED FORMULA [ChEBI:] synonym: "L-2-Amino acid" RELATED [KEGG COMPOUND:] synonym: "L-alpha-amino acid" EXACT [IUPAC:] synonym: "L-alpha-amino acids" EXACT IUPAC_NAME [IUPAC:] synonym: "L-alpha-amino acids" RELATED [ChEBI:] synonym: "L-Amino acid" RELATED [KEGG COMPOUND:] synonym: "N[C@@H]([*])C(O)=O" RELATED SMILES [ChEBI:] xref: KEGG COMPOUND:C00151 "KEGG COMPOUND" is_a: CHEBI:33704 ! alpha-amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:15729 name: L-ornithine namespace: chebi_ontology alt_id: CHEBI:13148 alt_id: CHEBI:21367 alt_id: CHEBI:6280 def: "An optically active form of ornithine having L-configuration." [] synonym: "(2S)-2,5-diaminopentanoic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "(S)-2,5-Diaminopentanoate" RELATED [KEGG COMPOUND:] synonym: "(S)-2,5-Diaminopentanoic acid" RELATED [KEGG COMPOUND:] synonym: "(S)-2,5-diaminovaleric acid" RELATED [KEGG COMPOUND:] synonym: "(S)-alpha,delta-diaminovaleric acid" RELATED [HMDB:] synonym: "(S)-ornithine" RELATED [ChemIDplus:] synonym: "C5H12N2O2" RELATED FORMULA [KEGG COMPOUND:] synonym: "InChI=1S/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9)/t4-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=AHLPHDHHMVZTML-BYPYZUCNSA-N" RELATED InChIKey [ChEBI:] synonym: "L-Ornithine" EXACT [KEGG COMPOUND:] synonym: "L-ornithine" EXACT [ChEBI:] synonym: "L-ornithine" EXACT IUPAC_NAME [IUPAC:] synonym: "NCCC[C@H](N)C(O)=O" RELATED SMILES [ChEBI:] xref: ChemIDplus:1722298 "Beilstein Registry Number" xref: ChemIDplus:70-26-8 "CAS Registry Number" xref: CiteXplore:15576628 "PubMed citation" xref: CiteXplore:17190852 "PubMed citation" xref: CiteXplore:18676473 "PubMed citation" xref: CiteXplore:19083482 "PubMed citation" xref: CiteXplore:19173225 "PubMed citation" xref: CiteXplore:22033378 "PubMed citation" xref: CiteXplore:22133808 "PubMed citation" xref: CiteXplore:22387109 "PubMed citation" xref: CiteXplore:22735334 "PubMed citation" xref: DrugBank:DB00129 "DrugBank" xref: Gmelin:327282 "Gmelin Registry Number" xref: HMDB:HMDB00214 "HMDB" xref: KEGG COMPOUND:70-26-8 "CAS Registry Number" xref: KEGG COMPOUND:C00077 "KEGG COMPOUND" xref: KEGG DRUG:D08302 "KEGG DRUG" xref: KNApSAcK:C00001384 "KNApSAcK" xref: MetaCyc:ORNITHINE "MetaCyc" xref: PDBeChem:ORN "PDBeChem" xref: Reaxys:1722298 "Reaxys Registry Number" xref: Wikipedia:Ornithine "Wikipedia" is_a: CHEBI:18257 ! ornithine is_a: CHEBI:83822 ! non-proteinogenic L-alpha-amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:15734 name: primary alcohol namespace: chebi_ontology alt_id: CHEBI:13676 alt_id: CHEBI:14887 alt_id: CHEBI:26262 alt_id: CHEBI:57489 alt_id: CHEBI:8406 def: "A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it." [] synonym: "1-Alcohol" RELATED [KEGG COMPOUND:] synonym: "[H]C([H])(O)[*]" RELATED SMILES [ChEBI:] synonym: "a primary alcohol" RELATED [UniProt:] synonym: "CH3OR" RELATED FORMULA [ChEBI:] synonym: "Primary alcohol" EXACT [KEGG COMPOUND:] synonym: "primary alcohols" RELATED [ChEBI:] xref: KEGG COMPOUND:C00226 "KEGG COMPOUND" is_a: CHEBI:30879 ! alcohol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:15738 name: staurosporine namespace: chebi_ontology alt_id: CHEBI:15106 alt_id: CHEBI:45788 alt_id: CHEBI:9252 def: "An indolocarbazole alkaloid that has formula C28H26N4O3." [] synonym: "(+)-Staurosporine" RELATED [ChemIDplus:] synonym: "(5S,6R,7R,9R)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one" RELATED [PDBeChem:] synonym: "(5S,6R,7R,9R)-6-methoxy-5-methyl-7-methylamino-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one" EXACT IUPAC_NAME [IUPAC:] synonym: "C28H26N4O3" RELATED FORMULA [KEGG COMPOUND:] synonym: "CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=HKSZLNNOFSGOKW-FYTWVXJKSA-N" RELATED InChIKey [ChEBI:] synonym: "Staurosporin" RELATED [ChemIDplus:] synonym: "STAUROSPORINE" EXACT [PDBeChem:] synonym: "Staurosporine" EXACT [KEGG COMPOUND:] synonym: "STS" RELATED [KEGG COMPOUND:] xref: ChemIDplus:62996-74-1 "CAS Registry Number" xref: DrugBank:DB02010 "DrugBank" xref: KEGG COMPOUND:62996-74-1 "CAS Registry Number" xref: KEGG COMPOUND:C02079 "KEGG COMPOUND" xref: KNApSAcK:C00018127 "KNApSAcK" xref: PDBeChem:STU "PDBeChem" is_a: CHEBI:37697 ! indolocarbazole alkaloid is_a: CHEBI:38165 ! organic heterooctacyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:15781 name: N(alpha),N(alpha),N(alpha)-trimethyl-L-histidine namespace: chebi_ontology alt_id: CHEBI:12673 alt_id: CHEBI:21909 alt_id: CHEBI:7460 def: "A N(alpha)-methyl-L-histidine that has formula C9H15N3O2." [] synonym: "(2S)-3-(1H-imidazol-4-yl)-2-(trimethylammonio)propanoate" EXACT IUPAC_NAME [IUPAC:] synonym: "(S)-alpha-Carboxy-N,N,N-trimethyl-1H-imidazole-4-ethanaminium hydroxide, inner salt" RELATED [ChemIDplus:] synonym: "C9H15N3O2" RELATED FORMULA [ChemIDplus:] synonym: "C[N+](C)(C)[C@@H](Cc1c[nH]cn1)C([O-])=O" RELATED SMILES [ChEBI:] synonym: "Hercynine" RELATED [KEGG COMPOUND:] synonym: "hercynine" RELATED [UniProt:] synonym: "InChI=1S/C9H15N3O2/c1-12(2,3)8(9(13)14)4-7-5-10-6-11-7/h5-6,8H,4H2,1-3H3,(H-,10,11,13,14)/t8-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=GPPYTCRVKHULJH-QMMMGPOBSA-N" RELATED InChIKey [ChEBI:] synonym: "Nalpha,Nalpha,Nalpha-Trimethyl-L-histidine" RELATED [KEGG COMPOUND:] xref: ChemIDplus:534-30-5 "CAS Registry Number" xref: KEGG COMPOUND:534-30-5 "CAS Registry Number" xref: KEGG COMPOUND:C05575 "KEGG COMPOUND" is_a: CHEBI:21911 ! N(alpha)-methyl-L-histidines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:15824 name: D-fructose namespace: chebi_ontology alt_id: CHEBI:12923 alt_id: CHEBI:20929 alt_id: CHEBI:4118 def: "Fructose is a levorotatory monosaccharide and an isomer of glucose. Although fructose is a hexose (6 carbon sugar), it generally exists as a 5-member hemiketal ring (a furanose)." [] synonym: "C6H12O6" RELATED FORMULA [KEGG COMPOUND:] synonym: "D-arabino-hex-2-ulose" EXACT IUPAC_NAME [IUPAC:] synonym: "D-arabino-Hexulose" RELATED [KEGG COMPOUND:] synonym: "D-Fru" RELATED [JCBN:] synonym: "D-fructose" EXACT IUPAC_NAME [IUPAC:] synonym: "Fruit sugar" RELATED [KEGG COMPOUND:] synonym: "Laevulose" RELATED [ChEBI:] synonym: "Levulose" RELATED [KEGG COMPOUND:] xref: ChemIDplus:57-48-7 "CAS Registry Number" xref: CiteXplore:22735334 "PubMed citation" xref: HMDB:HMDB00660 "HMDB" xref: KEGG COMPOUND:57-48-7 "CAS Registry Number" xref: KEGG COMPOUND:C00095 "KEGG COMPOUND" xref: MetaCyc:FRU "MetaCyc" xref: PDBeChem:FRU "PDBeChem" is_a: CHEBI:28757 ! fructose property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:15831 name: geranylgeranyl diphosphate namespace: chebi_ontology alt_id: CHEBI:14300 alt_id: CHEBI:24230 def: "A polyprenol diphosphate having geranylgeranyl as the polyprenyl component." [] synonym: "3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl trihydrogen diphosphate" EXACT IUPAC_NAME [IUPAC:] synonym: "C20H36O7P2" RELATED FORMULA [ChEBI:] synonym: "CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CCOP(O)(=O)OP(O)(O)=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C20H36O7P2/c1-17(2)9-6-10-18(3)11-7-12-19(4)13-8-14-20(5)15-16-26-29(24,25)27-28(21,22)23/h9,11,13,15H,6-8,10,12,14,16H2,1-5H3,(H,24,25)(H2,21,22,23)" RELATED InChI [ChEBI:] synonym: "InChIKey=OINNEUNVOZHBOX-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] xref: DrugBank:DB07841 "DrugBank" is_a: CHEBI:37531 ! polyprenol diphosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:15841 name: polypeptide namespace: chebi_ontology alt_id: CHEBI:14860 alt_id: CHEBI:8314 def: "A peptide containing ten or more amino acid residues." [] synonym: "C4H6N2O3R2(C2H2NOR)n" RELATED FORMULA [KEGG COMPOUND:] synonym: "polipeptido" RELATED [ChEBI:] synonym: "Polypeptid" RELATED [ChEBI:] synonym: "Polypeptide" EXACT [KEGG COMPOUND:] synonym: "polypeptide" EXACT [UniProt:] synonym: "polypeptides" EXACT IUPAC_NAME [IUPAC:] xref: KEGG COMPOUND:C00403 "KEGG COMPOUND" is_a: CHEBI:16670 ! peptide is_a: CHEBI:33839 ! macromolecule property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:15842 name: orotidine 5'-phosphate namespace: chebi_ontology alt_id: CHEBI:14699 alt_id: CHEBI:25723 alt_id: CHEBI:7788 def: "A pyrimidine ribonucleoside 5'-monophosphate having 6-carboxyuracil as the nucleobase." [] synonym: "2,6-dioxo-3-(5-O-phosphono-beta-D-ribofuranosyl)-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "6-carboxy-5'-uridylic acid" RELATED [ChEBI:] synonym: "C10H13N2O11P" RELATED FORMULA [KEGG COMPOUND:] synonym: "C10H13N2O11P" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C10H13N2O11P/c13-5-1-3(9(16)17)12(10(18)11-5)8-7(15)6(14)4(23-8)2-22-24(19,20)21/h1,4,6-8,14-15H,2H2,(H,16,17)(H,11,13,18)(H2,19,20,21)/t4-,6-,7-,8-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=KYOBSHFOBAOFBF-XVFCMESISA-N" RELATED InChIKey [ChEBI:] synonym: "O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)n1c(cc(=O)[nH]c1=O)C(O)=O" RELATED SMILES [ChEBI:] synonym: "orotidine 5'-(dihydrogen phosphate)" RELATED [ChEBI:] synonym: "Orotidine 5'-phosphate" EXACT [KEGG COMPOUND:] synonym: "Orotidylic acid" RELATED [KEGG COMPOUND:] xref: KEGG COMPOUND:2149-82-8 "CAS Registry Number" xref: KEGG COMPOUND:C01103 "KEGG COMPOUND" xref: KNApSAcK:C00007583 "KNApSAcK" xref: PDBeChem:OMP "PDBeChem" is_a: CHEBI:39457 ! pyrimidine ribonucleoside 5'-monophosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:15866 name: 2-deoxy-D-glucose namespace: chebi_ontology alt_id: CHEBI:1078 alt_id: CHEBI:11565 alt_id: CHEBI:11569 alt_id: CHEBI:19553 alt_id: CHEBI:57546 def: "A deoxy glucose having a hydroxy group replaced by a hydrogen at position 2; an antimetabolite of glucose with antiviral activity, which acts by inhibiting the glycosylation of glycoproteins and glycolipids. Used as an antiherpes agent." [] synonym: "2-deoxy-D-arabino-hexopyranose" EXACT IUPAC_NAME [IUPAC:] synonym: "2-Deoxy-D-arabino-hexose" RELATED [KEGG COMPOUND:] synonym: "2-Deoxy-D-glucose" EXACT [KEGG COMPOUND:] synonym: "2-Deoxy-D-mannose" RELATED [ChemIDplus:] synonym: "C6H12O5" RELATED FORMULA [KEGG COMPOUND:] synonym: "C6H12O5" RELATED FORMULA [ChEBI:] synonym: "D-2dGlc" RELATED [JCBN:] synonym: "D-arabino-2-Deoxyhexose" RELATED [KEGG COMPOUND:] synonym: "Deoxyglucose" RELATED [ChemIDplus:] synonym: "InChI=1S/C6H12O5/c7-2-1-4(9)6(11)5(10)3-8/h2,4-6,8-11H,1,3H2/t4-,5-,6+/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=VRYALKFFQXWPIH-PBXRRBTRSA-N" RELATED InChIKey [ChEBI:] synonym: "OC[C@@H](O)[C@@H](O)[C@H](O)CC=O" RELATED SMILES [ChEBI:] xref: ChemIDplus:154-17-6 "CAS Registry Number" xref: KEGG COMPOUND:154-17-6 "CAS Registry Number" xref: KEGG COMPOUND:C00586 "KEGG COMPOUND" is_a: CHEBI:23623 ! deoxyglucose property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:15889 name: sterol namespace: chebi_ontology alt_id: CHEBI:13688 alt_id: CHEBI:15114 alt_id: CHEBI:26771 alt_id: CHEBI:9266 def: "A 3-hydroxy steroid closely related to cholestan-3-ol." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "3-hydroxysteroids" RELATED [ChEBI:] synonym: "InChI=1S/C17H28O/c18-13-6-9-15-12(10-13)5-8-16-14-3-1-2-11(14)4-7-17(15)16/h11-18H,1-10H2" RELATED InChI [ChEBI:] synonym: "InChIKey=FPXSXMFOYWRHDX-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "OC1CCC2C(CCC3C4CCCC4CCC23)C1" RELATED SMILES [ChEBI:] synonym: "Sterol" EXACT [KEGG COMPOUND:] synonym: "sterol" EXACT [UniProt:] synonym: "sterols" EXACT IUPAC_NAME [IUPAC:] xref: KEGG COMPOUND:C00370 "KEGG COMPOUND" xref: LIPID MAPS:LMST01 "LIPID MAPS class" is_a: CHEBI:36834 ! 3-hydroxy steroid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:15904 name: long-chain fatty acid namespace: chebi_ontology alt_id: CHEBI:13655 alt_id: CHEBI:14529 alt_id: CHEBI:25075 alt_id: CHEBI:6528 def: "A fatty acid with a chain length ranging from C13 to C22." [] synonym: "CHO2R" RELATED FORMULA [ChEBI:] synonym: "Higher fatty acid" RELATED [KEGG COMPOUND:] synonym: "LCFA" RELATED [ChEBI:] synonym: "LCFAs" RELATED [ChEBI:] synonym: "Long-chain fatty acid" EXACT [KEGG COMPOUND:] synonym: "long-chain fatty acids" RELATED [ChEBI:] synonym: "OC([*])=O" RELATED SMILES [ChEBI:] xref: KEGG COMPOUND:C00638 "KEGG COMPOUND" is_a: CHEBI:35366 ! fatty acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:15926 name: dolichyl diphosphooligosaccharide namespace: chebi_ontology alt_id: CHEBI:14198 alt_id: CHEBI:14694 alt_id: CHEBI:23882 alt_id: CHEBI:25678 alt_id: CHEBI:4692 synonym: "C36H63N2O17P2R(C5H8)n" RELATED FORMULA [KEGG COMPOUND:] synonym: "Dolichyl diphosphooligosaccharide" EXACT [KEGG COMPOUND:] synonym: "dolichyl diphosphooligosaccharides" RELATED [ChEBI:] synonym: "Oligosaccharide-diphosphodolichol" RELATED [KEGG COMPOUND:] synonym: "Oligosaccharide-PP-Dol" RELATED [KEGG COMPOUND:] xref: KEGG COMPOUND:C04213 "KEGG COMPOUND" is_a: CHEBI:26186 ! polyprenyl phospho oligosaccharide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:15971 name: L-histidine namespace: chebi_ontology alt_id: CHEBI:13117 alt_id: CHEBI:21324 alt_id: CHEBI:43048 alt_id: CHEBI:43114 alt_id: CHEBI:43190 alt_id: CHEBI:43239 alt_id: CHEBI:6240 def: "The L-enantiomer of the amino acid histidine." [] synonym: "(2S)-2-amino-3-(1H-imidazol-4-yl)propanoic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "(S)-4-(2-Amino-2-carboxyethyl)imidazole" RELATED [DrugBank:] synonym: "(S)-alpha-amino-1H-Imidazole-4-propanoic acid" RELATED [NIST Chemistry WebBook:] synonym: "(S)-alpha-Amino-1H-imidazole-4-propionic acid" RELATED [KEGG COMPOUND:] synonym: "3-(1H-imidazol-3-ium-4-yl)-L-alanine" RELATED [PDBeChem:] synonym: "C6H9N3O2" RELATED FORMULA [KEGG COMPOUND:] synonym: "H" RELATED [ChEBI:] synonym: "His" RELATED [ChEBI:] synonym: "HISTIDINE" RELATED [PDBeChem:] synonym: "InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=HNDVDQJCIGZPNO-YFKPBYRVSA-N" RELATED InChIKey [ChEBI:] synonym: "L-(-)-histidine" RELATED [NIST Chemistry WebBook:] synonym: "L-Histidin" RELATED [ChEBI:] synonym: "L-Histidine" EXACT [KEGG COMPOUND:] synonym: "L-histidine" EXACT IUPAC_NAME [IUPAC:] synonym: "N[C@@H](Cc1c[nH]cn1)C(O)=O" RELATED SMILES [ChEBI:] xref: Beilstein:84088 "Beilstein Registry Number" xref: ChEBI:C00135 "KEGG COMPOUND" xref: ChemIDplus:71-00-1 "CAS Registry Number" xref: CiteXplore:15206581 "PubMed citation" xref: CiteXplore:21608102 "PubMed citation" xref: CiteXplore:21719207 "PubMed citation" xref: CiteXplore:22324399 "PubMed citation" xref: CiteXplore:22415677 "PubMed citation" xref: CiteXplore:22517640 "PubMed citation" xref: DrugBank:DB00117 "DrugBank" xref: ECMDB:ECMDB00177 "ECMDB" xref: Gmelin:83042 "Gmelin Registry Number" xref: HMDB:HMDB00177 "HMDB" xref: KEGG COMPOUND:71-00-1 "CAS Registry Number" xref: KEGG DRUG:D00032 "KEGG DRUG" xref: KNApSAcK:C00001363 "KNApSAcK" xref: MetaCyc:HIS "MetaCyc" xref: NIST Chemistry WebBook:71-00-1 "CAS Registry Number" xref: PDBeChem:HIS "PDBeChem" xref: Reaxys:84088 "Reaxys Registry Number" xref: Wikipedia:L-histidine "Wikipedia" xref: YMDB:YMDB00369 "YMDB" is_a: CHEBI:15705 ! L-alpha-amino acid is_a: CHEBI:27570 ! histidine is_a: CHEBI:83813 ! proteinogenic amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:15986 name: polynucleotide namespace: chebi_ontology alt_id: CHEBI:13672 alt_id: CHEBI:14859 alt_id: CHEBI:8312 def: "A nucleobase-containing molecular entity with a polymeric structure comprised of a linear sequence of 13 or more nucleotide residues." [] synonym: "C10H17O10PR2(C5H8O6PR)n" RELATED FORMULA [KEGG COMPOUND:] synonym: "Polynucleotide" EXACT [KEGG COMPOUND:] synonym: "polynucleotides" RELATED [ChEBI:] xref: KEGG COMPOUND:C00419 "KEGG COMPOUND" is_a: CHEBI:33695 ! information biomacromolecule is_a: CHEBI:61120 ! nucleobase-containing molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16000 name: ethanolamine namespace: chebi_ontology alt_id: CHEBI:14223 alt_id: CHEBI:23979 alt_id: CHEBI:272066 alt_id: CHEBI:42323 alt_id: CHEBI:4880 def: "A member of the class of ethanolamines that is ethane with an amino substituent at C-1 and a hydroxy substituent at C-2, making it both a primary amine and a primary alcohol." [] synonym: "1-amino-2-hydroxyethane" RELATED [ChemIDplus:] synonym: "2-amino-1-ethanol" RELATED [NIST Chemistry WebBook:] synonym: "2-Amino-ethanol" RELATED [ChEMBL:] synonym: "2-aminoethan-1-ol" RELATED [NIST Chemistry WebBook:] synonym: "2-aminoethanol" EXACT IUPAC_NAME [IUPAC:] synonym: "2-aminoethyl alcohol" RELATED [NIST Chemistry WebBook:] synonym: "2-Hydroxyethylamine" RELATED [KEGG COMPOUND:] synonym: "Aethanolamin" RELATED [ChemIDplus:] synonym: "Aminoethanol" RELATED [KEGG COMPOUND:] synonym: "beta-aminoethanol" RELATED [NIST Chemistry WebBook:] synonym: "beta-aminoethyl alcohol" RELATED [NIST Chemistry WebBook:] synonym: "beta-ethanolamine" RELATED [NIST Chemistry WebBook:] synonym: "beta-hydroxyethylamine" RELATED [NIST Chemistry WebBook:] synonym: "C2H7NO" RELATED FORMULA [KEGG COMPOUND:] synonym: "colamine" RELATED [ChemIDplus:] synonym: "ETA" RELATED [ChEBI:] synonym: "Ethanolamine" EXACT [KEGG COMPOUND:] synonym: "glycinol" RELATED [ChemIDplus:] synonym: "Hea" RELATED [IUPAC:] synonym: "InChI=1S/C2H7NO/c3-1-2-4/h4H,1-3H2" RELATED InChI [ChEBI:] synonym: "InChIKey=HZAXFHJVJLSVMW-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "MEA" RELATED [ChemIDplus:] synonym: "MONOETHANOLAMINE" RELATED [ChEMBL:] synonym: "monoethanolamine" RELATED [ChemIDplus:] synonym: "NCCO" RELATED SMILES [ChEBI:] xref: Beilstein:505944 "Beilstein Registry Number" xref: ChEMBL:15149650 "PubMed citation" xref: ChEMBL:6708049 "PubMed citation" xref: ChemIDplus:141-43-5 "CAS Registry Number" xref: CiteXplore:10930630 "PubMed citation" xref: CiteXplore:12834252 "PubMed citation" xref: CiteXplore:24023812 "PubMed citation" xref: CiteXplore:3654008 "PubMed citation" xref: CiteXplore:6196640 "PubMed citation" xref: DrugBank:DB03994 "DrugBank" xref: Gmelin:1650 "Gmelin Registry Number" xref: HMDB:HMDB00149 "HMDB" xref: KEGG COMPOUND:141-43-5 "CAS Registry Number" xref: KEGG COMPOUND:C00189 "KEGG COMPOUND" xref: KEGG DRUG:D05074 "KEGG DRUG" xref: KNApSAcK:C00007279 "KNApSAcK" xref: NIST Chemistry WebBook:141-43-5 "CAS Registry Number" xref: PDBeChem:ETA "PDBeChem" xref: Reaxys:505944 "Reaxys Registry Number" xref: UM-BBD:c0594 "UM-BBD compID" xref: Wikipedia:Ethanolamine "Wikipedia" is_a: CHEBI:15734 ! primary alcohol is_a: CHEBI:23981 ! ethanolamines is_a: CHEBI:32877 ! primary amine property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16016 name: glycerone namespace: chebi_ontology alt_id: CHEBI:14340 alt_id: CHEBI:24354 alt_id: CHEBI:39809 alt_id: CHEBI:5453 def: "A ketotriose consisting of acetone bearing hydroxy substituents at positions 1 and 3. The simplest member of the class of ketoses and the parent of the class of glycerones." [] synonym: "1,3-Dihydroxy-2-propanone" RELATED [KEGG COMPOUND:] synonym: "1,3-Dihydroxyacetone" RELATED [KEGG COMPOUND:] synonym: "1,3-Dihydroxydimethyl ketone" RELATED [ChemIDplus:] synonym: "1,3-Dihydroxypropan-2-one" RELATED [KEGG COMPOUND:] synonym: "1,3-dihydroxypropan-2-one" EXACT IUPAC_NAME [IUPAC:] synonym: "1,3-Dihydroxypropanone" RELATED [ChemIDplus:] synonym: "1,3-propanediol-2-one" RELATED [ChEBI:] synonym: "alpha,alpha'-dihydroxyacetone" RELATED [HMDB:] synonym: "Bis(hydroxymethyl) ketone" RELATED [HMDB:] synonym: "C3H6O3" RELATED FORMULA [KEGG COMPOUND:] synonym: "DHA" RELATED [ChEBI:] synonym: "DIHYDROXYACETONE" RELATED [PDBeChem:] synonym: "Dihydroxyacetone" RELATED [KEGG COMPOUND:] synonym: "Glycerone" EXACT [KEGG COMPOUND:] synonym: "glycerone" EXACT [UniProt:] synonym: "InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2" RELATED InChI [ChEBI:] synonym: "InChIKey=RXKJFZQQPQGTFL-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "OCC(=O)CO" RELATED SMILES [ChEBI:] xref: Beilstein:1740268 "Beilstein Registry Number" xref: ChemIDplus:96-26-4 "CAS Registry Number" xref: CiteXplore:20936361 "PubMed citation" xref: CiteXplore:21549029 "PubMed citation" xref: CiteXplore:21598406 "PubMed citation" xref: CiteXplore:23543734 "PubMed citation" xref: CiteXplore:23554234 "PubMed citation" xref: CiteXplore:23748086 "PubMed citation" xref: CiteXplore:24209782 "PubMed citation" xref: DrugBank:DB01775 "DrugBank" xref: HMDB:HMDB01882 "HMDB" xref: KEGG COMPOUND:96-26-4 "CAS Registry Number" xref: KEGG COMPOUND:C00184 "KEGG COMPOUND" xref: KEGG DRUG:D07841 "KEGG DRUG" xref: MetaCyc:DIHYDROXYACETONE "MetaCyc" xref: NIST Chemistry WebBook:96-26-4 "CAS Registry Number" xref: PDBeChem:2HA "PDBeChem" xref: Reaxys:1740268 "Reaxys Registry Number" xref: Wikipedia:Dihydroxyacetone "Wikipedia" is_a: CHEBI:24982 ! ketotriose property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16038 name: phosphatidylethanolamine namespace: chebi_ontology alt_id: CHEBI:12701 alt_id: CHEBI:14803 alt_id: CHEBI:26030 alt_id: CHEBI:26031 alt_id: CHEBI:45210 alt_id: CHEBI:7661 alt_id: CHEBI:8129 def: "A class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxy group of ethanolamine." [] synonym: "(3-Phosphatidyl)-ethanolamine" RELATED [KEGG COMPOUND:] synonym: "(3-Phosphatidyl)ethanolamine" RELATED [KEGG COMPOUND:] synonym: "1,2-diacyl-sn-glycero-3-phosphoethanolamine" RELATED [LIPID MAPS:] synonym: "1-Acyl-2-acyl-sn-glycero-3-phosphoethanolamine" RELATED [KEGG COMPOUND:] synonym: "C7H12NO8PR2" RELATED FORMULA [ChEBI:] synonym: "Cephalin" RELATED [KEGG COMPOUND:] synonym: "NCCOP(O)(=O)OCC(COC([*])=O)OC([*])=O" RELATED SMILES [ChEBI:] synonym: "O-(1-beta-Acyl-2-acyl-sn-glycero-3-phospho)ethanolamine" RELATED [KEGG COMPOUND:] synonym: "PE" RELATED [ChEBI:] synonym: "phosphatidyl(amino)ethanols" EXACT IUPAC_NAME [IUPAC:] synonym: "PHOSPHATIDYLETHANOLAMINE" EXACT [PDBeChem:] synonym: "Phosphatidylethanolamine" EXACT [KEGG COMPOUND:] synonym: "phosphatidylethanolamines" EXACT IUPAC_NAME [IUPAC:] synonym: "phosphatidylethanolamines" RELATED [ChEBI:] synonym: "PtdEtn" RELATED [ChEBI:] xref: CiteXplore:10540156 "PubMed citation" xref: CiteXplore:11042504 "PubMed citation" xref: CiteXplore:11159918 "PubMed citation" xref: CiteXplore:11829744 "PubMed citation" xref: CiteXplore:12139474 "PubMed citation" xref: CiteXplore:15653902 "PubMed citation" xref: CiteXplore:16037249 "PubMed citation" xref: CiteXplore:16303767 "PubMed citation" xref: CiteXplore:16620109 "PubMed citation" xref: CiteXplore:18034796 "PubMed citation" xref: CiteXplore:18259190 "PubMed citation" xref: CiteXplore:18398168 "PubMed citation" xref: CiteXplore:18462396 "PubMed citation" xref: CiteXplore:18570887 "PubMed citation" xref: CiteXplore:18957134 "PubMed citation" xref: CiteXplore:19393163 "PubMed citation" xref: CiteXplore:23354482 "PubMed citation" xref: CiteXplore:23369752 "PubMed citation" xref: CiteXplore:23543734 "PubMed citation" xref: CiteXplore:3196084 "PubMed citation" xref: CiteXplore:7980848 "PubMed citation" xref: DrugBank:DB04327 "DrugBank" xref: KEGG COMPOUND:C00350 "KEGG COMPOUND" xref: LIPID MAPS:LMGP02010000 "LIPID MAPS instance" xref: PDBeChem:PTY "PDBeChem" xref: Wikipedia:Phosphatidylethanolamine "Wikipedia" is_a: CHEBI:36314 ! glycerophosphoethanolamine property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16134 name: ammonia namespace: chebi_ontology alt_id: CHEBI:13405 alt_id: CHEBI:13406 alt_id: CHEBI:13407 alt_id: CHEBI:13771 alt_id: CHEBI:22533 alt_id: CHEBI:44269 alt_id: CHEBI:44284 alt_id: CHEBI:44404 alt_id: CHEBI:7434 def: "An azane that consists of a single nitrogen atom covelently bonded to three hydrogen atoms." [] synonym: "[H]N([H])[H]" RELATED SMILES [ChEBI:] synonym: "[NH3]" RELATED [MolBase:] synonym: "AMINO SUBSTITUTION GROUP" RELATED [PDBeChem:] synonym: "AMMONIA" EXACT [PDBeChem:] synonym: "Ammonia" EXACT [KEGG COMPOUND:] synonym: "ammonia" EXACT IUPAC_NAME [IUPAC:] synonym: "ammoniac" RELATED [ChEBI:] synonym: "Ammoniak" RELATED [ChemIDplus:] synonym: "amoniaco" RELATED [ChEBI:] synonym: "azane" EXACT IUPAC_NAME [IUPAC:] synonym: "H3N" RELATED FORMULA [KEGG COMPOUND:] synonym: "InChI=1S/H3N/h1H3" RELATED InChI [ChEBI:] synonym: "InChIKey=QGZKDVFQNNGYKY-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "NH3" RELATED [KEGG COMPOUND:] synonym: "NH3" RELATED [IUPAC:] synonym: "NH3" RELATED [UniProt:] synonym: "NITROGEN" RELATED [PDBeChem:] synonym: "R-717" RELATED [ChEBI:] synonym: "spirit of hartshorn" RELATED [ChemIDplus:] xref: Beilstein:3587154 "Beilstein Registry Number" xref: ChemIDplus:7664-41-7 "CAS Registry Number" xref: CiteXplore:110589 "PubMed citation" xref: CiteXplore:11139349 "PubMed citation" xref: CiteXplore:11540049 "PubMed citation" xref: CiteXplore:11746427 "PubMed citation" xref: CiteXplore:11783653 "PubMed citation" xref: CiteXplore:13753780 "PubMed citation" xref: CiteXplore:14663195 "PubMed citation" xref: CiteXplore:15092448 "PubMed citation" xref: CiteXplore:15094021 "PubMed citation" xref: CiteXplore:15554424 "PubMed citation" xref: CiteXplore:15969015 "PubMed citation" xref: CiteXplore:16008360 "PubMed citation" xref: CiteXplore:16050680 "PubMed citation" xref: CiteXplore:16348008 "PubMed citation" xref: CiteXplore:16349403 "PubMed citation" xref: CiteXplore:16614889 "PubMed citation" xref: CiteXplore:16664306 "PubMed citation" xref: CiteXplore:16842901 "PubMed citation" xref: CiteXplore:17025297 "PubMed citation" xref: CiteXplore:17439666 "PubMed citation" xref: CiteXplore:17569513 "PubMed citation" xref: CiteXplore:17737668 "PubMed citation" xref: CiteXplore:18670398 "PubMed citation" xref: CiteXplore:22002069 "PubMed citation" xref: CiteXplore:22081570 "PubMed citation" xref: CiteXplore:22088435 "PubMed citation" xref: CiteXplore:22100291 "PubMed citation" xref: CiteXplore:22130175 "PubMed citation" xref: CiteXplore:22150211 "PubMed citation" xref: CiteXplore:22240068 "PubMed citation" xref: CiteXplore:22290316 "PubMed citation" xref: CiteXplore:22342082 "PubMed citation" xref: CiteXplore:22385337 "PubMed citation" xref: CiteXplore:22443779 "PubMed citation" xref: CiteXplore:22560242 "PubMed citation" xref: Gmelin:79 "Gmelin Registry Number" xref: HMDB:HMDB00051 "HMDB" xref: KEGG COMPOUND:7664-41-7 "CAS Registry Number" xref: KEGG COMPOUND:C00014 "KEGG COMPOUND" xref: KEGG DRUG:D02916 "KEGG DRUG" xref: KNApSAcK:C00007267 "KNApSAcK" xref: MetaCyc:AMMONIA "MetaCyc" xref: MolBase:930 "MolBase" xref: NIST Chemistry WebBook:7664-41-7 "CAS Registry Number" xref: PDBeChem:NH3 "PDBeChem" xref: Reaxys:3587154 "Reaxys Registry Number" xref: Wikipedia:Ammonia "Wikipedia" is_a: CHEBI:35107 ! azane is_a: CHEBI:37176 ! mononuclear parent hydride property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16189 name: sulfate namespace: chebi_ontology alt_id: CHEBI:15135 alt_id: CHEBI:45687 alt_id: CHEBI:9335 def: "A sulfur oxoanion obtained by deprotonation of both OH groups of sulfuric acid." [] synonym: "[O-]S([O-])(=O)=O" RELATED SMILES [ChEBI:] synonym: "[SO4](2-)" RELATED [IUPAC:] synonym: "InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2" RELATED InChI [ChEBI:] synonym: "InChIKey=QAOWNCQODCNURD-UHFFFAOYSA-L" RELATED InChIKey [ChEBI:] synonym: "O4S" RELATED FORMULA [ChEBI:] synonym: "SO4(2-)" RELATED [IUPAC:] synonym: "Sulfate" EXACT [KEGG COMPOUND:] synonym: "sulfate" EXACT [UniProt:] synonym: "sulfate" EXACT IUPAC_NAME [IUPAC:] synonym: "Sulfate anion(2-)" RELATED [HMDB:] synonym: "Sulfate dianion" RELATED [HMDB:] synonym: "SULFATE ION" RELATED [PDBeChem:] synonym: "Sulfate(2-)" RELATED [HMDB:] synonym: "Sulfuric acid ion(2-)" RELATED [HMDB:] synonym: "sulphate" RELATED [ChEBI:] synonym: "sulphate ion" RELATED [ChEBI:] synonym: "tetraoxidosulfate(2-)" EXACT IUPAC_NAME [IUPAC:] synonym: "tetraoxosulfate(2-)" EXACT IUPAC_NAME [IUPAC:] synonym: "tetraoxosulfate(VI)" EXACT IUPAC_NAME [IUPAC:] xref: Beilstein:3648446 "Beilstein Registry Number" xref: ChemIDplus:14808-79-8 "CAS Registry Number" xref: CiteXplore:11200094 "PubMed citation" xref: CiteXplore:11452993 "PubMed citation" xref: CiteXplore:11581495 "PubMed citation" xref: CiteXplore:11798107 "PubMed citation" xref: CiteXplore:12166931 "PubMed citation" xref: CiteXplore:12668033 "PubMed citation" xref: CiteXplore:14597181 "PubMed citation" xref: CiteXplore:15093386 "PubMed citation" xref: CiteXplore:15984785 "PubMed citation" xref: CiteXplore:16186560 "PubMed citation" xref: CiteXplore:16345535 "PubMed citation" xref: CiteXplore:16347366 "PubMed citation" xref: CiteXplore:16348007 "PubMed citation" xref: CiteXplore:16483812 "PubMed citation" xref: CiteXplore:16534979 "PubMed citation" xref: CiteXplore:16656509 "PubMed citation" xref: CiteXplore:16742508 "PubMed citation" xref: CiteXplore:16742518 "PubMed citation" xref: CiteXplore:17120760 "PubMed citation" xref: CiteXplore:17420092 "PubMed citation" xref: CiteXplore:17439666 "PubMed citation" xref: CiteXplore:17709180 "PubMed citation" xref: CiteXplore:18398178 "PubMed citation" xref: CiteXplore:18815700 "PubMed citation" xref: CiteXplore:18846414 "PubMed citation" xref: CiteXplore:19047345 "PubMed citation" xref: CiteXplore:19244483 "PubMed citation" xref: CiteXplore:19544990 "PubMed citation" xref: CiteXplore:19628332 "PubMed citation" xref: CiteXplore:19812358 "PubMed citation" xref: Gmelin:2120 "Gmelin Registry Number" xref: HMDB:HMDB01448 "HMDB" xref: KEGG COMPOUND:C00059 "KEGG COMPOUND" xref: KEGG DRUG:D05963 "KEGG DRUG" xref: MetaCyc:SULFATE "MetaCyc" xref: NIST Chemistry WebBook:14808-79-8 "CAS Registry Number" xref: PDBeChem:SO4 "PDBeChem" xref: Reaxys:3648446 "Reaxys Registry Number" xref: Wikipedia:Sulfate "Wikipedia" is_a: CHEBI:33482 ! sulfur oxoanion is_a: CHEBI:48154 ! sulfur oxide is_a: CHEBI:79388 ! divalent inorganic anion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16236 name: ethanol namespace: chebi_ontology alt_id: CHEBI:14222 alt_id: CHEBI:23978 alt_id: CHEBI:30878 alt_id: CHEBI:30880 alt_id: CHEBI:42377 alt_id: CHEBI:44594 alt_id: CHEBI:4879 def: "A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group." [] synonym: "1-hydroxyethane" RELATED [ChemIDplus:] synonym: "[CH2Me(OH)]" RELATED [MolBase:] synonym: "[OEtH]" RELATED [MolBase:] synonym: "Aethanol" RELATED [ChemIDplus:] synonym: "Aethylalkohol" RELATED [ChemIDplus:] synonym: "alcohol" RELATED [NIST Chemistry WebBook:] synonym: "alcohol etilico" RELATED [ChEBI:] synonym: "alcool ethylique" RELATED [ChemIDplus:] synonym: "Alkohol" RELATED [ChemIDplus:] synonym: "C2H5OH" RELATED [ChEBI:] synonym: "C2H6O" RELATED FORMULA [KEGG COMPOUND:] synonym: "CCO" RELATED SMILES [ChEBI:] synonym: "Dehydrated ethanol" RELATED BRAND_NAME [KEGG DRUG:] synonym: "etanol" RELATED [ChEBI:] synonym: "ETHANOL" EXACT [PDBeChem:] synonym: "Ethanol" EXACT [KEGG COMPOUND:] synonym: "ethanol" EXACT [UniProt:] synonym: "ethanol" EXACT [ChEBI:] synonym: "ethanol" EXACT IUPAC_NAME [IUPAC:] synonym: "ethanol" EXACT [PDBeChem:] synonym: "Ethyl alcohol" RELATED [KEGG COMPOUND:] synonym: "EtOH" RELATED [ChemIDplus:] synonym: "hydroxyethane" RELATED [ChemIDplus:] synonym: "InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3" RELATED InChI [ChEBI:] synonym: "InChIKey=LFQSCWFLJHTTHZ-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "Methylcarbinol" RELATED [KEGG COMPOUND:] synonym: "OXYDIMETHYLENE GROUP" RELATED [PDBeChem:] synonym: "spiritus vini" RELATED [ChEBI:] xref: Beilstein:1718733 "Beilstein Registry Number" xref: ChEBI:c0038 "UM-BBD compID" xref: ChemIDplus:64-17-5 "CAS Registry Number" xref: CiteXplore:11046114 "PubMed citation" xref: CiteXplore:11090978 "PubMed citation" xref: CiteXplore:11198720 "PubMed citation" xref: CiteXplore:11200745 "PubMed citation" xref: CiteXplore:11262320 "PubMed citation" xref: CiteXplore:11303910 "PubMed citation" xref: CiteXplore:11333032 "PubMed citation" xref: CiteXplore:11505026 "PubMed citation" xref: CiteXplore:11590970 "PubMed citation" xref: CiteXplore:11728426 "PubMed citation" xref: CiteXplore:11750186 "PubMed citation" xref: CiteXplore:11754521 "PubMed citation" xref: CiteXplore:11810019 "PubMed citation" xref: CiteXplore:11826039 "PubMed citation" xref: CiteXplore:11981228 "PubMed citation" xref: CiteXplore:12824058 "PubMed citation" xref: CiteXplore:12829422 "PubMed citation" xref: CiteXplore:12888778 "PubMed citation" xref: CiteXplore:12946583 "PubMed citation" xref: CiteXplore:14674846 "PubMed citation" xref: CiteXplore:15019421 "PubMed citation" xref: CiteXplore:15239123 "PubMed citation" xref: CiteXplore:15285839 "PubMed citation" xref: CiteXplore:15464411 "PubMed citation" xref: CiteXplore:15465973 "PubMed citation" xref: CiteXplore:15749123 "PubMed citation" xref: CiteXplore:15900217 "PubMed citation" xref: CiteXplore:15902919 "PubMed citation" xref: CiteXplore:16084479 "PubMed citation" xref: CiteXplore:16133132 "PubMed citation" xref: CiteXplore:16352430 "PubMed citation" xref: CiteXplore:16390872 "PubMed citation" xref: CiteXplore:16737463 "PubMed citation" xref: CiteXplore:16891664 "PubMed citation" xref: CiteXplore:16934862 "PubMed citation" xref: CiteXplore:17043811 "PubMed citation" xref: CiteXplore:17190852 "PubMed citation" xref: CiteXplore:17663926 "PubMed citation" xref: CiteXplore:17687877 "PubMed citation" xref: CiteXplore:18095657 "PubMed citation" xref: CiteXplore:18249266 "PubMed citation" xref: CiteXplore:18320157 "PubMed citation" xref: CiteXplore:18347649 "PubMed citation" xref: CiteXplore:18408978 "PubMed citation" xref: CiteXplore:18411066 "PubMed citation" xref: CiteXplore:18456322 "PubMed citation" xref: CiteXplore:18513832 "PubMed citation" xref: CiteXplore:18922656 "PubMed citation" xref: CiteXplore:18925476 "PubMed citation" xref: CiteXplore:19280886 "PubMed citation" xref: CiteXplore:19359288 "PubMed citation" xref: CiteXplore:19384566 "PubMed citation" xref: CiteXplore:19458312 "PubMed citation" xref: CiteXplore:19851413 "PubMed citation" xref: CiteXplore:19901811 "PubMed citation" xref: CiteXplore:21600756 "PubMed citation" xref: CiteXplore:21762181 "PubMed citation" xref: CiteXplore:21881875 "PubMed citation" xref: CiteXplore:21967628 "PubMed citation" xref: CiteXplore:22019193 "PubMed citation" xref: CiteXplore:22222864 "PubMed citation" xref: CiteXplore:22261437 "PubMed citation" xref: CiteXplore:22286266 "PubMed citation" xref: CiteXplore:22306018 "PubMed citation" xref: CiteXplore:22331491 "PubMed citation" xref: CiteXplore:22336593 "PubMed citation" xref: DrugBank:DB00898 "DrugBank" xref: Gmelin:787 "Gmelin Registry Number" xref: HMDB:HMDB00108 "HMDB" xref: KEGG COMPOUND:64-17-5 "CAS Registry Number" xref: KEGG COMPOUND:C00469 "KEGG COMPOUND" xref: KEGG DRUG:D00068 "KEGG DRUG" xref: KEGG DRUG:D06542 "KEGG DRUG" xref: KNApSAcK:C00019560 "KNApSAcK" xref: MetaCyc:ETOH "MetaCyc" xref: MolBase:858 "MolBase" xref: MolBase:859 "MolBase" xref: NIST Chemistry WebBook:64-17-5 "CAS Registry Number" xref: PDBeChem:EOH "PDBeChem" xref: PDBeChem:OHE "PDBeChem" xref: PDBeChem:OXA "PDBeChem" xref: Reaxys:1718733 "Reaxys Registry Number" xref: Wikipedia:Ethanol "Wikipedia" is_a: CHEBI:23982 ! ethanols is_a: CHEBI:50584 ! alkyl alcohol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16240 name: hydrogen peroxide namespace: chebi_ontology alt_id: CHEBI:13354 alt_id: CHEBI:13355 alt_id: CHEBI:24637 alt_id: CHEBI:44812 alt_id: CHEBI:5586 def: "An inorganic peroxide that has formula H2O2." [] synonym: "[H]OO[H]" RELATED SMILES [ChEBI:] synonym: "[OH(OH)]" RELATED [MolBase:] synonym: "bis(hydridooxygen)(O--O)" EXACT IUPAC_NAME [IUPAC:] synonym: "dihydrogen dioxide" RELATED [IUPAC:] synonym: "dihydrogen peroxide" EXACT IUPAC_NAME [IUPAC:] synonym: "dihydrogen(peroxide)" EXACT IUPAC_NAME [IUPAC:] synonym: "dioxidane" EXACT IUPAC_NAME [IUPAC:] synonym: "H2O2" RELATED [UniProt:] synonym: "H2O2" RELATED FORMULA [KEGG COMPOUND:] synonym: "H2O2" RELATED [KEGG COMPOUND:] synonym: "HOOH" RELATED [IUPAC:] synonym: "HYDROGEN PEROXIDE" EXACT [PDBeChem:] synonym: "Hydrogen peroxide" EXACT [KEGG COMPOUND:] synonym: "hydrogen peroxide" EXACT [PDBeChem:] synonym: "hydrogen peroxide" EXACT IUPAC_NAME [IUPAC:] synonym: "InChI=1S/H2O2/c1-2/h1-2H" RELATED InChI [ChEBI:] synonym: "InChIKey=MHAJPDPJQMAIIY-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "Oxydol" RELATED [KEGG COMPOUND:] xref: Beilstein:3587191 "Beilstein Registry Number" xref: ChemIDplus:7722-84-1 "CAS Registry Number" xref: Gmelin:509 "Gmelin Registry Number" xref: KEGG COMPOUND:7722-84-1 "CAS Registry Number" xref: KEGG COMPOUND:C00027 "KEGG COMPOUND" xref: KEGG DRUG:D00008 "KEGG DRUG" xref: MolBase:932 "MolBase" xref: NIST Chemistry WebBook:7722-84-1 "CAS Registry Number" xref: PDBeChem:PEO "PDBeChem" is_a: CHEBI:24837 ! inorganic peroxide is_a: CHEBI:26523 ! reactive oxygen species property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16247 name: phospholipid namespace: chebi_ontology alt_id: CHEBI:14816 alt_id: CHEBI:26063 alt_id: CHEBI:8150 def: "A lipid containing phosphoric acid as a mono- or di-ester. The term encompasses phosphatidic acids and phosphoglycerides." [] synonym: "C5H6O8PR3" RELATED FORMULA [KEGG COMPOUND:] synonym: "Phospholipid" EXACT [KEGG COMPOUND:] synonym: "phospholipid derivative" RELATED [UniProt:] synonym: "phospholipids" RELATED [ChEBI:] xref: KEGG COMPOUND:C00865 "KEGG COMPOUND" is_a: CHEBI:18059 ! lipid is_a: CHEBI:25703 ! organic phosphate is_a: CHEBI:37734 ! phosphoric ester property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16284 name: dATP namespace: chebi_ontology alt_id: CHEBI:10491 alt_id: CHEBI:14069 alt_id: CHEBI:19238 alt_id: CHEBI:42290 def: "A purine 2'-deoxyribonucleoside 5'-triphosphate having adenine as the nucleobase." [] synonym: "2'-deoxyadenosine 5'-(tetrahydrogen triphosphate)" EXACT IUPAC_NAME [IUPAC:] synonym: "2'-deoxyadenosine 5'-(tetrahydrogen triphosphate)" RELATED [PDBeChem:] synonym: "2'-DEOXYADENOSINE 5'-TRIPHOSPHATE" RELATED [PDBeChem:] synonym: "2'-Deoxyadenosine 5'-triphosphate" RELATED [KEGG COMPOUND:] synonym: "2'-deoxyadenosine 5'-triphosphate" RELATED [ChEBI:] synonym: "C10H16N5O12P3" RELATED FORMULA [KEGG COMPOUND:] synonym: "dATP" EXACT [KEGG COMPOUND:] synonym: "Deoxyadenosine 5'-triphosphate" RELATED [KEGG COMPOUND:] synonym: "Deoxyadenosine triphosphate" RELATED [KEGG COMPOUND:] synonym: "InChI=1S/C10H16N5O12P3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(25-7)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H,22,23)(H2,11,12,13)(H2,17,18,19)/t5-,6+,7+/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=SUYVUBYJARFZHO-RRKCRQDMSA-N" RELATED InChIKey [ChEBI:] synonym: "Nc1ncnc2n(cnc12)[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1" RELATED SMILES [ChEBI:] xref: DrugBank:DB03222 "DrugBank" xref: KEGG COMPOUND:1927-31-7 "CAS Registry Number" xref: KEGG COMPOUND:C00131 "KEGG COMPOUND" xref: PDBeChem:DTP "PDBeChem" is_a: CHEBI:19237 ! 2'-deoxyadenosine 5'-phosphate is_a: CHEBI:37042 ! purine 2'-deoxyribonucleoside 5'-triphosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16301 name: nitrite namespace: chebi_ontology alt_id: CHEBI:14658 alt_id: CHEBI:44396 alt_id: CHEBI:7585 def: "The nitrogen oxoanion formed by loss of a proton from nitrous acid." [] synonym: "[NO2](-)" RELATED [IUPAC:] synonym: "[O-]N=O" RELATED SMILES [ChEBI:] synonym: "dioxidonitrate(1-)" EXACT IUPAC_NAME [IUPAC:] synonym: "dioxonitrate(1-)" EXACT IUPAC_NAME [IUPAC:] synonym: "dioxonitrate(III)" EXACT IUPAC_NAME [IUPAC:] synonym: "InChI=1S/HNO2/c2-1-3/h(H,2,3)/p-1" RELATED InChI [ChEBI:] synonym: "InChIKey=IOVCWXUNBOPUCH-UHFFFAOYSA-M" RELATED InChIKey [ChEBI:] synonym: "Nitrit" RELATED [ChEBI:] synonym: "Nitrite" EXACT [KEGG COMPOUND:] synonym: "nitrite" EXACT IUPAC_NAME [IUPAC:] synonym: "nitrite" EXACT [UniProt:] synonym: "nitrite anion" RELATED [ChemIDplus:] synonym: "NITRITE ION" RELATED [PDBeChem:] synonym: "nitrite(1-)" RELATED [ChemIDplus:] synonym: "nitrous acid, ion(1-)" RELATED [ChemIDplus:] synonym: "NO2" RELATED FORMULA [ChEBI:] synonym: "NO2(-)" RELATED [IUPAC:] xref: ChemIDplus:14797-65-0 "CAS Registry Number" xref: Gmelin:977 "Gmelin Registry Number" xref: KEGG COMPOUND:C00088 "KEGG COMPOUND" xref: NIST Chemistry WebBook:14797-65-0 "CAS Registry Number" xref: PDBeChem:NO2 "PDBeChem" xref: Wikipedia:Nitrite "Wikipedia" is_a: CHEBI:33458 ! nitrogen oxoanion is_a: CHEBI:62764 ! reactive nitrogen species is_a: CHEBI:79389 ! monovalent inorganic anion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16311 name: dCTP namespace: chebi_ontology alt_id: CHEBI:10494 alt_id: CHEBI:14072 alt_id: CHEBI:19243 def: "A 2'-deoxycytidine phosphate having cytosine as the nucleobase." [] synonym: "2'-deoxycytidine 5'-(tetrahydrogen triphosphate)" EXACT IUPAC_NAME [IUPAC:] synonym: "2'-Deoxycytidine 5'-triphosphate" RELATED [KEGG COMPOUND:] synonym: "C9H16N3O13P3" RELATED FORMULA [KEGG COMPOUND:] synonym: "dCTP" EXACT [KEGG COMPOUND:] synonym: "Deoxycytidine 5'-triphosphate" RELATED [KEGG COMPOUND:] synonym: "Deoxycytidine triphosphate" RELATED [KEGG COMPOUND:] synonym: "InChI=1S/C9H16N3O13P3/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(23-8)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H,20,21)(H2,10,11,14)(H2,15,16,17)/t5-,6+,8+/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=RGWHQCVHVJXOKC-SHYZEUOFSA-N" RELATED InChIKey [ChEBI:] synonym: "Nc1ccn([C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)n1" RELATED SMILES [ChEBI:] xref: DrugBank:DB03258 "DrugBank" xref: KEGG COMPOUND:2056-98-6 "CAS Registry Number" xref: KEGG COMPOUND:C00458 "KEGG COMPOUND" xref: PDBeChem:DCP "PDBeChem" is_a: CHEBI:37043 ! pyrimidine 2'-deoxyribonucleoside 5'-triphosphate is_a: CHEBI:37092 ! 2'-deoxycytidine phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16349 name: L-citrulline namespace: chebi_ontology alt_id: CHEBI:13092 alt_id: CHEBI:21257 alt_id: CHEBI:41489 alt_id: CHEBI:6203 def: "The L-enantiomer of citrulline." [] synonym: "(2S)-2-amino-5-(carbamoylamino)pentanoic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "(S)-2-Amino-5-ureidopentanoic acid" RELATED [HMDB:] synonym: "2-Amino-5-ureidovaleric acid" RELATED [KEGG COMPOUND:] synonym: "alpha-amino-delta-ureidovaleric acid" RELATED [ChemIDplus:] synonym: "C6H13N3O3" RELATED FORMULA [KEGG COMPOUND:] synonym: "Cit" RELATED [ChemIDplus:] synonym: "CITRULLINE" RELATED [PDBeChem:] synonym: "Citrulline" RELATED [KEGG COMPOUND:] synonym: "delta-ureidonorvaline" RELATED [ChemIDplus:] synonym: "InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=RHGKLRLOHDJJDR-BYPYZUCNSA-N" RELATED InChIKey [ChEBI:] synonym: "L-2-Amino-5-ureidovaleric acid" RELATED [HMDB:] synonym: "L-Citrulline" EXACT [KEGG COMPOUND:] synonym: "L-citrulline" EXACT IUPAC_NAME [IUPAC:] synonym: "N(5)-(aminocarbonyl)-L-ornithine" RELATED [ChemIDplus:] synonym: "N(5)-carbamoyl-L-ornithine" EXACT IUPAC_NAME [IUPAC:] synonym: "N(delta)-carbamylornithine" RELATED [ChemIDplus:] synonym: "N5-(Aminocarbonyl)ornithine" RELATED [DrugBank:] synonym: "N5-carbamoylornithine" RELATED [DrugBank:] synonym: "N[C@@H](CCCNC(N)=O)C(O)=O" RELATED SMILES [ChEBI:] xref: Beilstein:1725416 "Beilstein Registry Number" xref: Beilstein:6055157 "Beilstein Registry Number" xref: ChemIDplus:372-75-8 "CAS Registry Number" xref: CiteXplore:11862757 "PubMed citation" xref: CiteXplore:17190852 "PubMed citation" xref: CiteXplore:18022291 "PubMed citation" xref: CiteXplore:19173225 "PubMed citation" xref: CiteXplore:21067832 "PubMed citation" xref: CiteXplore:21915076 "PubMed citation" xref: CiteXplore:21955999 "PubMed citation" xref: CiteXplore:22119809 "PubMed citation" xref: CiteXplore:22345866 "PubMed citation" xref: CiteXplore:22348173 "PubMed citation" xref: CiteXplore:22387109 "PubMed citation" xref: CiteXplore:22388927 "PubMed citation" xref: CiteXplore:22402328 "PubMed citation" xref: CiteXplore:22402472 "PubMed citation" xref: CiteXplore:22512552 "PubMed citation" xref: DrugBank:DB00155 "DrugBank" xref: ECMDB:ECMDB00904 "ECMDB" xref: Gmelin:774677 "Gmelin Registry Number" xref: HMDB:HMDB00904 "HMDB" xref: KEGG COMPOUND:372-75-8 "CAS Registry Number" xref: KEGG COMPOUND:C00327 "KEGG COMPOUND" xref: KEGG DRUG:D07706 "KEGG DRUG" xref: KNApSAcK:C00001348 "KNApSAcK" xref: MetaCyc:L-CITRULLINE "MetaCyc" xref: PDBeChem:CIR "PDBeChem" xref: Reaxys:1725416 "Reaxys Registry Number" xref: Wikipedia:Citrulline "Wikipedia" xref: YMDB:YMDB00060 "YMDB" is_a: CHEBI:18211 ! citrulline property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16350 name: 2'-deoxyribonucleoside 5'-diphosphate namespace: chebi_ontology alt_id: CHEBI:14119 alt_id: CHEBI:37071 alt_id: CHEBI:4424 synonym: "2'-deoxyribonucleoside 5'-diphosphates" RELATED [ChEBI:] synonym: "C5H11O9P2R" RELATED FORMULA [KEGG COMPOUND:] synonym: "Deoxynucleoside diphosphate" RELATED [KEGG COMPOUND:] synonym: "O[C@H]1C[C@H]([*])O[C@@H]1COP(O)(=O)OP(O)(O)=O" RELATED SMILES [ChEBI:] xref: KEGG COMPOUND:C03786 "KEGG COMPOUND" is_a: CHEBI:37016 ! 2'-deoxyribonucleoside 5'-phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16381 name: 2'-deoxyribonucleoside 5'-triphosphate namespace: chebi_ontology alt_id: CHEBI:14121 alt_id: CHEBI:37072 alt_id: CHEBI:4426 synonym: "2'-deoxynucleoside 5'-(tetrahydrogen triphosphate)" EXACT IUPAC_NAME [IUPAC:] synonym: "2'-deoxyribonucleoside 5'-triphosphates" RELATED [ChEBI:] synonym: "C5H12O12P3R" RELATED FORMULA [ChEBI:] synonym: "Deoxynucleoside triphosphate" RELATED [KEGG COMPOUND:] synonym: "O[C@H]1C[C@H]([*])O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O" RELATED SMILES [ChEBI:] xref: KEGG COMPOUND:C00677 "KEGG COMPOUND" is_a: CHEBI:37016 ! 2'-deoxyribonucleoside 5'-phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16385 name: organic sulfide namespace: chebi_ontology alt_id: CHEBI:13694 alt_id: CHEBI:26960 alt_id: CHEBI:9340 def: "Compounds having the structure RSR (R =/= H). Such compounds were once called thioethers." [] synonym: "[*]S[*]" RELATED SMILES [ChEBI:] synonym: "organic sulfides" RELATED [ChEBI:] synonym: "RSR" RELATED [IUPAC:] synonym: "SR2" RELATED FORMULA [KEGG COMPOUND:] synonym: "Sulfide" RELATED [KEGG COMPOUND:] synonym: "sulfides" EXACT IUPAC_NAME [IUPAC:] synonym: "Thioether" RELATED [KEGG COMPOUND:] synonym: "thioether" RELATED [UniProt:] synonym: "thioethers" RELATED [IUPAC:] xref: KEGG COMPOUND:C00297 "KEGG COMPOUND" is_a: CHEBI:26822 ! sulfide is_a: CHEBI:33261 ! organosulfur compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16389 name: ubiquinones namespace: chebi_ontology alt_id: CHEBI:15279 alt_id: CHEBI:27186 alt_id: CHEBI:9852 def: "Any benzoquinone derived from 2,3-dimethoxy-5-methylbenzoquinone; one of a group of naturally occurring homologues. The redox-active quinoid moiety usually carries a polyprenoid side chain at position 6, the number of isoprenoid units in which is species-specific. Ubiquinones are involved in the control of mitochondrial electron transport, and are also potent anti-oxidants." [] synonym: "a ubiquinone" RELATED [UniProt:] synonym: "C9H10O4(C5H8)n" RELATED FORMULA [ChEBI:] synonym: "Coenzym Q" RELATED [ChEBI:] synonym: "Coenzyme Q" RELATED [KEGG COMPOUND:] synonym: "coenzyme Q" RELATED [ChEBI:] synonym: "coenzymes Q" RELATED [ChEBI:] synonym: "CoQ" RELATED [KEGG COMPOUND:] synonym: "Koenzym Q" RELATED [ChEBI:] synonym: "mitochondrial ubiquinone" RELATED [ChEBI:] synonym: "mitochondrial ubiquinones" RELATED [ChEBI:] synonym: "mitoquinones" RELATED [ChEBI:] synonym: "Q" RELATED [KEGG COMPOUND:] synonym: "Ubichinon" RELATED [ChEBI:] synonym: "Ubiquinone" RELATED [KEGG COMPOUND:] synonym: "Ubiquinones" EXACT [ChemIDplus:] xref: ChemIDplus:1339-63-5 "CAS Registry Number" xref: CiteXplore:15788391 "PubMed citation" xref: CiteXplore:7599208 "PubMed citation" xref: KEGG COMPOUND:1339-63-5 "CAS Registry Number" xref: KEGG COMPOUND:C00399 "KEGG COMPOUND" is_a: CHEBI:22729 ! benzoquinones is_a: CHEBI:26255 ! prenylquinone property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16397 name: formamide namespace: chebi_ontology alt_id: CHEBI:14275 alt_id: CHEBI:24078 alt_id: CHEBI:40895 alt_id: CHEBI:5143 def: "The simplest monocarboxylic acid amide, obtained by formal condensation of formic acid with ammonia. The parent of the class of formaldehydes." [] synonym: "[H]C(N)=O" RELATED SMILES [ChEBI:] synonym: "Ameisensaeureamid" RELATED [ChEBI:] synonym: "carbamaldehyde" RELATED [NIST Chemistry WebBook:] synonym: "CH3NO" RELATED FORMULA [KEGG COMPOUND:] synonym: "Formamid" RELATED [ChEBI:] synonym: "FORMAMIDE" EXACT [PDBeChem:] synonym: "Formamide" EXACT [KEGG COMPOUND:] synonym: "formamide" EXACT [UniProt:] synonym: "formamide" EXACT IUPAC_NAME [IUPAC:] synonym: "formimidic acid" RELATED [ChemIDplus:] synonym: "InChI=1S/CH3NO/c2-1-3/h1H,(H2,2,3)" RELATED InChI [ChEBI:] synonym: "InChIKey=ZHNUHDYFZUAESO-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "Methanamid" RELATED [ChEBI:] synonym: "Methanamide" RELATED [KEGG COMPOUND:] xref: Beilstein:505995 "Beilstein Registry Number" xref: ChemIDplus:75-12-7 "CAS Registry Number" xref: CiteXplore:11282235 "PubMed citation" xref: CiteXplore:11545392 "PubMed citation" xref: CiteXplore:12115814 "PubMed citation" xref: CiteXplore:14750843 "PubMed citation" xref: CiteXplore:15082074 "PubMed citation" xref: CiteXplore:17184725 "PubMed citation" xref: CiteXplore:19334838 "PubMed citation" xref: CiteXplore:21215846 "PubMed citation" xref: CiteXplore:21229996 "PubMed citation" xref: CiteXplore:21573300 "PubMed citation" xref: CiteXplore:21647491 "PubMed citation" xref: CiteXplore:21647492 "PubMed citation" xref: CiteXplore:21769603 "PubMed citation" xref: CiteXplore:21932847 "PubMed citation" xref: Gmelin:824 "Gmelin Registry Number" xref: HMDB:HMDB01536 "HMDB" xref: KEGG COMPOUND:75-12-7 "CAS Registry Number" xref: KEGG COMPOUND:C00488 "KEGG COMPOUND" xref: MetaCyc:FORMAMIDE "MetaCyc" xref: NIST Chemistry WebBook:75-12-7 "CAS Registry Number" xref: PDBeChem:ARF "PDBeChem" xref: Reaxys:505995 "Reaxys Registry Number" xref: UM-BBD:c0796 "UM-BBD compID" xref: Wikipedia:Formamide "Wikipedia" is_a: CHEBI:24079 ! formamides is_a: CHEBI:29347 ! monocarboxylic acid amide is_a: CHEBI:64708 ! one-carbon compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16414 name: L-valine namespace: chebi_ontology alt_id: CHEBI:13186 alt_id: CHEBI:21417 alt_id: CHEBI:46282 alt_id: CHEBI:46376 alt_id: CHEBI:46418 alt_id: CHEBI:46484 alt_id: CHEBI:6321 def: "The L-enantiomer of valine." [] synonym: "(2S)-2-amino-3-methylbutanoic acid" RELATED [IUPAC:] synonym: "(S)-valine" RELATED [ChemIDplus:] synonym: "2-Amino-3-methylbutyric acid" RELATED [KEGG COMPOUND:] synonym: "C5H11NO2" RELATED FORMULA [KEGG COMPOUND:] synonym: "CC(C)[C@H](N)C(O)=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=KZSNJWFQEVHDMF-BYPYZUCNSA-N" RELATED InChIKey [ChEBI:] synonym: "L-(+)-alpha-Aminoisovaleric acid" RELATED [HMDB:] synonym: "L-alpha-Amino-beta-methylbutyric acid" RELATED [HMDB:] synonym: "L-Valin" RELATED [ChEBI:] synonym: "L-Valine" EXACT [KEGG COMPOUND:] synonym: "L-Valine" EXACT [PDBeChem:] synonym: "L-valine" EXACT IUPAC_NAME [IUPAC:] synonym: "V" RELATED [ChEBI:] synonym: "Val" RELATED [ChEBI:] synonym: "VALINE" RELATED [PDBeChem:] xref: Beilstein:1721136 "Beilstein Registry Number" xref: ChemIDplus:72-18-4 "CAS Registry Number" xref: CiteXplore:14608070 "PubMed citation" xref: CiteXplore:17670823 "PubMed citation" xref: CiteXplore:21706252 "PubMed citation" xref: CiteXplore:22138982 "PubMed citation" xref: CiteXplore:22287678 "PubMed citation" xref: CiteXplore:22585822 "PubMed citation" xref: DrugBank:DB00161 "DrugBank" xref: Gmelin:2827 "Gmelin Registry Number" xref: HMDB:HMDB00883 "HMDB" xref: KEGG COMPOUND:72-18-4 "CAS Registry Number" xref: KEGG COMPOUND:C00183 "KEGG COMPOUND" xref: KEGG DRUG:D00039 "KEGG DRUG" xref: KNApSAcK:C00001398 "KNApSAcK" xref: MetaCyc:VAL "MetaCyc" xref: NIST Chemistry WebBook:72-18-4 "CAS Registry Number" xref: PDBeChem:VAL "PDBeChem" xref: Reaxys:1721136 "Reaxys Registry Number" xref: Wikipedia:L-valine "Wikipedia" is_a: CHEBI:26463 ! pyruvate family amino acid is_a: CHEBI:27266 ! valine is_a: CHEBI:83813 ! proteinogenic amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16449 name: alanine namespace: chebi_ontology alt_id: CHEBI:13748 alt_id: CHEBI:22277 alt_id: CHEBI:2539 def: "An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2." [] synonym: "2-Aminopropanoic acid" RELATED [KEGG COMPOUND:] synonym: "2-aminopropanoic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "2-Aminopropionic acid" RELATED [KEGG COMPOUND:] synonym: "A" RELATED [ChEBI:] synonym: "ALA" RELATED [ChEBI:] synonym: "Alanin" RELATED [ChEBI:] synonym: "alanina" RELATED [ChEBI:] synonym: "Alanine" EXACT [KEGG COMPOUND:] synonym: "alanine" EXACT IUPAC_NAME [IUPAC:] synonym: "alanine" EXACT [UniProt:] synonym: "C3H7NO2" RELATED FORMULA [KEGG COMPOUND:] synonym: "CC(N)C(O)=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)" RELATED InChI [ChEBI:] synonym: "InChIKey=QNAYBMKLOCPYGJ-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] xref: Beilstein:635807 "Beilstein Registry Number" xref: ChemIDplus:302-72-7 "CAS Registry Number" xref: CiteXplore:17439666 "PubMed citation" xref: CiteXplore:22264337 "PubMed citation" xref: Gmelin:2449 "Gmelin Registry Number" xref: KEGG COMPOUND:302-72-7 "CAS Registry Number" xref: KEGG COMPOUND:C01401 "KEGG COMPOUND" xref: NIST Chemistry WebBook:302-72-7 "CAS Registry Number" xref: Reaxys:635807 "Reaxys Registry Number" xref: Wikipedia:Alanine "Wikipedia" is_a: CHEBI:33704 ! alpha-amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16460 name: polyprenol phosphate namespace: chebi_ontology alt_id: CHEBI:14862 alt_id: CHEBI:26202 alt_id: CHEBI:8319 synonym: "C5H11O4P(C5H8)n" RELATED FORMULA [KEGG COMPOUND:] synonym: "polyprenol phosphates" RELATED [ChEBI:] synonym: "Polyprenyl phosphate" RELATED [KEGG COMPOUND:] synonym: "polyprenyl phosphate" RELATED [UniProt:] xref: KEGG COMPOUND:C01048 "KEGG COMPOUND" is_a: CHEBI:26250 ! prenol phosphate is_a: CHEBI:26875 ! terpenyl phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16467 name: L-arginine namespace: chebi_ontology alt_id: CHEBI:13077 alt_id: CHEBI:21235 alt_id: CHEBI:42927 alt_id: CHEBI:6185 def: "An L-alpha-amino acid that is the L-isomer of arginine." [] synonym: "(2S)-2-amino-5-(carbamimidamido)pentanoic acid" RELATED [IUPAC:] synonym: "(2S)-2-amino-5-guanidinopentanoic acid" RELATED [JCBN:] synonym: "(S)-2-amino-5-guanidinopentanoic acid" RELATED [ChEBI:] synonym: "(S)-2-Amino-5-guanidinovaleric acid" RELATED [KEGG COMPOUND:] synonym: "2-AMINO-5-GUANIDINO-PENTANOIC ACID" RELATED [PDBeChem:] synonym: "Arg" RELATED [DrugBank:] synonym: "arginine" RELATED INN [KEGG DRUG:] synonym: "C6H14N4O2" RELATED FORMULA [KEGG COMPOUND:] synonym: "C6H15N4O2" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=ODKSFYDXXFIFQN-BYPYZUCNSA-N" RELATED InChIKey [ChEBI:] synonym: "L-(+)-arginine" RELATED [NIST Chemistry WebBook:] synonym: "L-Arg" RELATED [DrugBank:] synonym: "L-Arginin" RELATED [ChEBI:] synonym: "L-Arginine" EXACT [KEGG COMPOUND:] synonym: "L-arginine" EXACT IUPAC_NAME [IUPAC:] synonym: "N[C@@H](CCCNC(N)=N)C(O)=O" RELATED SMILES [ChEBI:] synonym: "R" RELATED [MetaCyc:] xref: ChemIDplus:1725413 "Beilstein Registry Number" xref: ChemIDplus:74-79-3 "CAS Registry Number" xref: CiteXplore:10848923 "PubMed citation" xref: CiteXplore:11139824 "PubMed citation" xref: CiteXplore:11300497 "PubMed citation" xref: CiteXplore:11898853 "PubMed citation" xref: CiteXplore:12812828 "PubMed citation" xref: CiteXplore:15016745 "PubMed citation" xref: CiteXplore:15465805 "PubMed citation" xref: CiteXplore:16056256 "PubMed citation" xref: CiteXplore:16416365 "PubMed citation" xref: CiteXplore:17168727 "PubMed citation" xref: CiteXplore:17439666 "PubMed citation" xref: CiteXplore:19030957 "PubMed citation" xref: CiteXplore:21600268 "PubMed citation" xref: CiteXplore:21814794 "PubMed citation" xref: CiteXplore:22179117 "PubMed citation" xref: CiteXplore:22243793 "PubMed citation" xref: CiteXplore:22251130 "PubMed citation" xref: CiteXplore:22361732 "PubMed citation" xref: CiteXplore:22425811 "PubMed citation" xref: CiteXplore:22428068 "PubMed citation" xref: CiteXplore:22439203 "PubMed citation" xref: CiteXplore:22553931 "PubMed citation" xref: CiteXplore:22619480 "PubMed citation" xref: CiteXplore:22626826 "PubMed citation" xref: CiteXplore:22652429 "PubMed citation" xref: CiteXplore:22667467 "PubMed citation" xref: CiteXplore:22709481 "PubMed citation" xref: CiteXplore:8070089 "PubMed citation" xref: DrugBank:DB00125 "DrugBank" xref: ECMDB:ECMDB00517 "ECMDB" xref: Gmelin:83283 "Gmelin Registry Number" xref: HMDB:HMDB00517 "HMDB" xref: KEGG COMPOUND:74-79-3 "CAS Registry Number" xref: KEGG COMPOUND:C00062 "KEGG COMPOUND" xref: KEGG DRUG:D02982 "KEGG DRUG" xref: KNApSAcK:C00001340 "KNApSAcK" xref: MetaCyc:ARG "MetaCyc" xref: NIST Chemistry WebBook:74-79-3 "CAS Registry Number" xref: PDBeChem:ARG "PDBeChem" xref: PDBeChem:GND "PDBeChem" xref: Reaxys:1725413 "Reaxys Registry Number" xref: Wikipedia:L-arginine "Wikipedia" xref: YMDB:YMDB00592 "YMDB" is_a: CHEBI:24318 ! glutamine family amino acid is_a: CHEBI:29016 ! arginine is_a: CHEBI:83813 ! proteinogenic amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16480 name: nitric oxide namespace: chebi_ontology alt_id: CHEBI:14657 alt_id: CHEBI:25546 alt_id: CHEBI:44452 alt_id: CHEBI:7583 def: "A nitrogen oxide which is a free radical, each molecule of which consists of one nitrogen and one oxygen atom." [] synonym: "(.)NO" RELATED [ChEBI:] synonym: "(NO)(.)" RELATED [IUPAC:] synonym: "[N]=O" RELATED SMILES [ChEBI:] synonym: "[NO]" RELATED [MolBase:] synonym: "EDRF" RELATED [ChEBI:] synonym: "endothelium-derived relaxing factor" RELATED [ChEBI:] synonym: "InChI=1S/NO/c1-2" RELATED InChI [ChEBI:] synonym: "InChIKey=MWUXSHHQAYIFBG-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "mononitrogen monoxide" RELATED [ChemIDplus:] synonym: "monoxido de nitrogeno" RELATED [ChEBI:] synonym: "monoxyde d'azote" RELATED [ChEBI:] synonym: "NITRIC OXIDE" EXACT [PDBeChem:] synonym: "Nitric oxide" EXACT [KEGG COMPOUND:] synonym: "nitric oxide" EXACT [UniProt:] synonym: "nitrogen monooxide" RELATED [IUPAC:] synonym: "Nitrogen monoxide" RELATED [KEGG COMPOUND:] synonym: "nitrogen monoxide" RELATED [IUPAC:] synonym: "nitrosyl" RELATED [IUPAC:] synonym: "NO" RELATED [KEGG COMPOUND:] synonym: "NO" RELATED FORMULA [KEGG COMPOUND:] synonym: "NO(.)" RELATED [IUPAC:] synonym: "oxido de nitrogeno(II)" RELATED [ChEBI:] synonym: "oxido nitrico" RELATED [ChEBI:] synonym: "oxidonitrogen(.)" EXACT IUPAC_NAME [IUPAC:] synonym: "oxoazanyl" EXACT IUPAC_NAME [IUPAC:] synonym: "oxyde azotique" RELATED [ChEBI:] synonym: "oxyde nitrique" RELATED [ChEBI:] synonym: "Stickstoff(II)-oxid" RELATED [ChEBI:] synonym: "Stickstoffmonoxid" RELATED [ChEBI:] xref: ChemIDplus:10102-43-9 "CAS Registry Number" xref: DrugBank:DB00435 "DrugBank" xref: Gmelin:451 "Gmelin Registry Number" xref: KEGG COMPOUND:10102-43-9 "CAS Registry Number" xref: KEGG COMPOUND:C00533 "KEGG COMPOUND" xref: KEGG DRUG:D00074 "KEGG DRUG" xref: MolBase:943 "MolBase" xref: NIST Chemistry WebBook:10102-43-9 "CAS Registry Number" xref: PDBeChem:NO "PDBeChem" xref: Reaxys:3587257 "Reaxys Registry Number" xref: Wikipedia:Nitric oxide "Wikipedia" is_a: CHEBI:26523 ! reactive oxygen species is_a: CHEBI:35196 ! nitrogen oxide is_a: CHEBI:36871 ! inorganic radical is_a: CHEBI:62764 ! reactive nitrogen species property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16497 name: dGTP namespace: chebi_ontology alt_id: CHEBI:10497 alt_id: CHEBI:14076 alt_id: CHEBI:19247 def: "A purine 2'-deoxyribonucleoside 5'-triphosphate having guanine as the nucleobase." [] synonym: "2'-deoxyguanosine 5'-(tetrahydrogen triphosphate)" EXACT IUPAC_NAME [IUPAC:] synonym: "2'-Deoxyguanosine 5'-triphosphate" RELATED [KEGG COMPOUND:] synonym: "2'-deoxyguanosine 5'-triphosphate" RELATED [ChEBI:] synonym: "C10H16N5O13P3" RELATED FORMULA [KEGG COMPOUND:] synonym: "Deoxyguanosine 5'-triphosphate" RELATED [KEGG COMPOUND:] synonym: "Deoxyguanosine triphosphate" RELATED [KEGG COMPOUND:] synonym: "dGTP" EXACT [KEGG COMPOUND:] synonym: "InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=HAAZLUGHYHWQIW-KVQBGUIXSA-N" RELATED InChIKey [ChEBI:] synonym: "Nc1nc2n(cnc2c(=O)[nH]1)[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1" RELATED SMILES [ChEBI:] xref: CiteXplore:11096070 "PubMed citation" xref: CiteXplore:22844265 "PubMed citation" xref: CiteXplore:7929110 "PubMed citation" xref: DrugBank:DB02181 "DrugBank" xref: ECMDB:ECMDB01440 "ECMDB" xref: HMDB:HMDB01440 "HMDB" xref: KEGG COMPOUND:2564-35-4 "CAS Registry Number" xref: KEGG COMPOUND:C00286 "KEGG COMPOUND" xref: KNApSAcK:C00019346 "KNApSAcK" xref: PDBeChem:DGT "PDBeChem" xref: Reaxys:73481 "Reaxys Registry Number" xref: YMDB:YMDB00744 "YMDB" is_a: CHEBI:23625 ! deoxyguanosine phosphate is_a: CHEBI:37042 ! purine 2'-deoxyribonucleoside 5'-triphosphate is_a: CHEBI:63573 ! guanyl deoxyribonucleotide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16516 name: 2'-deoxyribonucleoside triphosphate namespace: chebi_ontology alt_id: CHEBI:11397 alt_id: CHEBI:19258 alt_id: CHEBI:839 synonym: "2'-Deoxyribonucleoside triphosphate" EXACT [KEGG COMPOUND:] synonym: "2'-deoxyribonucleoside triphosphate" EXACT [UniProt:] synonym: "2'-deoxyribonucleoside triphosphates" RELATED [ChEBI:] synonym: "C5H12O12P3R" RELATED FORMULA [KEGG COMPOUND:] xref: ChEBI:C00677 "KEGG COMPOUND" xref: KEGG COMPOUND:C04283 "KEGG COMPOUND" is_a: CHEBI:17326 ! nucleoside triphosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16521 name: lanosterol namespace: chebi_ontology alt_id: CHEBI:14500 alt_id: CHEBI:25011 alt_id: CHEBI:43584 alt_id: CHEBI:6374 def: "A tetracyclic triterpenoid that is lanosta-8,24-diene substituted by a beta-hydroxy group at position 3. It is the compound from which all steroids are derived." [] synonym: "(3beta)-lanosta-8,24-dien-3-ol" RELATED [ChemIDplus:] synonym: "(3beta,5alpha)-4,4,14-trimethylcholesta-8,24-dien-3-ol" RELATED [ChemIDplus:] synonym: "4,4',14alpha-Trimethyl-5alpha-cholesta-8,24-dien-3beta-ol" RELATED [KEGG COMPOUND:] synonym: "[H][C@@]1(CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]1(C)CC[C@H](O)C(C)(C)[C@]1([H])CC3)[C@H](C)CCC=C(C)C" RELATED SMILES [ChEBI:] synonym: "C30H50O" RELATED FORMULA [KEGG COMPOUND:] synonym: "InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=CAHGCLMLTWQZNJ-BQNIITSRSA-N" RELATED InChIKey [ChEBI:] synonym: "lanosta-8,24-dien-3beta-ol" EXACT IUPAC_NAME [IUPAC:] synonym: "Lanosterin" RELATED [HMDB:] synonym: "LANOSTEROL" EXACT [PDBeChem:] synonym: "Lanosterol" EXACT [KEGG COMPOUND:] synonym: "lanosterol" EXACT [UniProt:] xref: ChemIDplus:2226449 "Beilstein Registry Number" xref: ChemIDplus:79-63-0 "CAS Registry Number" xref: CiteXplore:14660793 "PubMed citation" xref: CiteXplore:22988818 "PubMed citation" xref: CiteXplore:24525128 "PubMed citation" xref: DrugBank:DB03696 "DrugBank" xref: HMDB:HMDB01251 "HMDB" xref: KEGG COMPOUND:79-63-0 "CAS Registry Number" xref: KEGG COMPOUND:C01724 "KEGG COMPOUND" xref: KNApSAcK:C00003657 "KNApSAcK" xref: LIPID MAPS:LMST01010017 "LIPID MAPS instance" xref: MetaCyc:LANOSTEROL "MetaCyc" xref: PDBeChem:LAN "PDBeChem" xref: Reaxys:2226449 "Reaxys Registry Number" xref: Wikipedia:Lanosterol "Wikipedia" is_a: CHEBI:26893 ! tetracyclic triterpenoid is_a: CHEBI:35348 ! 3beta-sterol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16634 name: raffinose namespace: chebi_ontology alt_id: CHEBI:15015 alt_id: CHEBI:26521 alt_id: CHEBI:49843 alt_id: CHEBI:8771 def: "A trisaccharide composed of alpha-D-galactopyranose, alpha-D-glucopyranose and beta-D-fructofuranose joined in sequence by 1->6 and 1<->2 glycosidic linkages, respectively." [] synonym: "6G-alpha-D-galactosylsucrose" RELATED [KEGG COMPOUND:] synonym: "alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranosyl beta-D-fructofuranoside" RELATED [JCBN:] synonym: "alpha-D-Galp-(1->6)-alpha-D-Glcp-(1<->2)-beta-D-Fruf" RELATED [JCBN:] synonym: "beta-D-fructofuranosyl alpha-D-galactopyranosyl-(1->6)-alpha-D-glucopyranoside" EXACT IUPAC_NAME [IUPAC:] synonym: "C18H32O16" RELATED FORMULA [KEGG COMPOUND:] synonym: "Gossypose" RELATED [KEGG COMPOUND:] synonym: "InChI=1S/C18H32O16/c19-1-5-8(22)11(25)13(27)16(31-5)30-3-7-9(23)12(26)14(28)17(32-7)34-18(4-21)15(29)10(24)6(2-20)33-18/h5-17,19-29H,1-4H2/t5-,6-,7-,8+,9-,10-,11+,12+,13-,14-,15+,16+,17-,18+/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=MUPFEKGTMRGPLJ-ZQSKZDJDSA-N" RELATED InChIKey [ChEBI:] synonym: "Melitose" RELATED [KEGG COMPOUND:] synonym: "Melitriose" RELATED [KEGG COMPOUND:] synonym: "OC[C@H]1O[C@H](OC[C@H]2O[C@H](O[C@]3(CO)O[C@H](CO)[C@@H](O)[C@@H]3O)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@H]1O" RELATED SMILES [ChEBI:] synonym: "Raffinose" EXACT [KEGG COMPOUND:] synonym: "raffinose" EXACT [UniProt:] xref: ChemIDplus:512-69-6 "CAS Registry Number" xref: CiteXplore:23317449 "PubMed citation" xref: CiteXplore:23879777 "PubMed citation" xref: CiteXplore:23882273 "PubMed citation" xref: CiteXplore:24001862 "PubMed citation" xref: CiteXplore:24354450 "PubMed citation" xref: CiteXplore:24360500 "PubMed citation" xref: HMDB:HMDB03213 "HMDB" xref: KEGG COMPOUND:512-69-6 "CAS Registry Number" xref: KEGG COMPOUND:C00492 "KEGG COMPOUND" xref: KEGG GLYCAN:G00249 "KEGG GLYCAN" xref: KNApSAcK:C00001145 "KNApSAcK" xref: MetaCyc:CPD-1099 "MetaCyc" xref: PDBeChem:RAF "PDBeChem" xref: Reaxys:99543 "Reaxys Registry Number" xref: Wikipedia:Raffinose "Wikipedia" is_a: CHEBI:27150 ! trisaccharide is_a: CHEBI:74961 ! raffinose family oligosaccharide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16643 name: L-methionine namespace: chebi_ontology alt_id: CHEBI:13141 alt_id: CHEBI:21360 alt_id: CHEBI:43990 alt_id: CHEBI:6271 def: "The L-enantiomer of methionine." [] synonym: "(2S)-2-amino-4-(methylsulfanyl)butanoic acid" RELATED [IUPAC:] synonym: "(S)-2-amino-4-(methylthio)butanoic acid" RELATED [ChemIDplus:] synonym: "(S)-2-amino-4-(methylthio)butyric acid" RELATED [ChemIDplus:] synonym: "(S)-methionine" RELATED [ChEBI:] synonym: "C5H11NO2S" RELATED FORMULA [KEGG COMPOUND:] synonym: "CSCC[C@H](N)C(O)=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=FFEARJCKVFRZRR-BYPYZUCNSA-N" RELATED InChIKey [ChEBI:] synonym: "L-(-)-methionine" RELATED [NIST Chemistry WebBook:] synonym: "L-alpha-amino-gamma-methylmercaptobutyric acid" RELATED [NIST Chemistry WebBook:] synonym: "L-Methionin" RELATED [ChEBI:] synonym: "L-Methionine" EXACT [KEGG COMPOUND:] synonym: "L-methionine" EXACT IUPAC_NAME [IUPAC:] synonym: "M" RELATED [ChEBI:] synonym: "Met" RELATED [ChEBI:] synonym: "METHIONINE" RELATED [PDBeChem:] synonym: "Methionine" RELATED [KEGG DRUG:] synonym: "Methionine" RELATED [KEGG COMPOUND:] xref: ChemIDplus:63-68-3 "CAS Registry Number" xref: CiteXplore:16575097 "PubMed citation" xref: CiteXplore:21683740 "PubMed citation" xref: CiteXplore:21946918 "PubMed citation" xref: CiteXplore:22200379 "PubMed citation" xref: CiteXplore:22370952 "PubMed citation" xref: CiteXplore:22448874 "PubMed citation" xref: CiteXplore:22517898 "PubMed citation" xref: CiteXplore:24126240 "PubMed citation" xref: CiteXplore:24939187 "PubMed citation" xref: CiteXplore:5764336 "PubMed citation" xref: DrugBank:DB00134 "DrugBank" xref: ECMDB:ECMDB00696 "ECMDB" xref: Gmelin:26935 "Gmelin Registry Number" xref: HMDB:HMDB00696 "HMDB" xref: KEGG COMPOUND:63-68-3 "CAS Registry Number" xref: KEGG COMPOUND:C00073 "KEGG COMPOUND" xref: KEGG DRUG:D00019 "KEGG DRUG" xref: KNApSAcK:C00001379 "KNApSAcK" xref: MetaCyc:MET "MetaCyc" xref: NIST Chemistry WebBook:63-68-3 "CAS Registry Number" xref: PDBeChem:MET_LFOH "PDBeChem" xref: Reaxys:1722294 "Reaxys Registry Number" xref: YMDB:YMDB00318 "YMDB" is_a: CHEBI:16811 ! methionine is_a: CHEBI:22658 ! aspartate family amino acid is_a: CHEBI:83813 ! proteinogenic amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16646 name: carbohydrate namespace: chebi_ontology alt_id: CHEBI:15131 alt_id: CHEBI:23008 alt_id: CHEBI:9318 def: "Any member of the class of organooxygen compounds that is a polyhydroxy-aldehyde or -ketone or a lactol resulting from their intramolecular condensation (monosaccharides); substances derived from these by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom; and polymeric products arising by intermolecular acetal formation between two or more such molecules (disaccharides, polysaccharides and oligosaccharides). Carbohydrates contain only carbon, hydrogen and oxygen atoms; prior to any oxidation or reduction, most have the empirical formula Cm(H2O)n. Compounds obtained from carbohydrates by substitution, etc., are known as carbohydrate derivatives and may contain other elements. Cyclitols are generally not regarded as carbohydrates." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "carbohidrato" RELATED [IUPAC:] synonym: "carbohidratos" RELATED [IUPAC:] synonym: "carbohydrate" EXACT IUPAC_NAME [IUPAC:] synonym: "carbohydrates" EXACT IUPAC_NAME [IUPAC:] synonym: "glucide" RELATED [ChEBI:] synonym: "glucides" RELATED [ChEBI:] synonym: "glucido" RELATED [ChEBI:] synonym: "glucidos" RELATED [ChEBI:] synonym: "hydrates de carbone" RELATED [ChEBI:] synonym: "Kohlenhydrat" RELATED [ChEBI:] synonym: "Kohlenhydrate" RELATED [ChEBI:] synonym: "saccharide" RELATED [IUPAC:] synonym: "saccharides" RELATED [IUPAC:] synonym: "saccharidum" RELATED [ChEBI:] xref: Wikipedia:Carbohydrate "Wikipedia" is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16670 name: peptide namespace: chebi_ontology alt_id: CHEBI:14753 alt_id: CHEBI:25906 alt_id: CHEBI:7990 def: "Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc." [] synonym: "(C2H2NOR)nC2H3NOR" RELATED FORMULA [ChEBI:] synonym: "Peptid" RELATED [ChEBI:] synonym: "Peptide" EXACT [KEGG COMPOUND:] synonym: "peptides" EXACT IUPAC_NAME [IUPAC:] synonym: "peptido" RELATED [ChEBI:] synonym: "peptidos" RELATED [ChEBI:] xref: KEGG COMPOUND:C00012 "KEGG COMPOUND" is_a: CHEBI:37622 ! carboxamide is_a: CHEBI:50047 ! organic amino compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16701 name: nucleoside 5'-phosphate namespace: chebi_ontology alt_id: CHEBI:14674 alt_id: CHEBI:25603 alt_id: CHEBI:7650 def: "A ribosyl or deoxyribosyl derivative of a pyrimidine or purine base in which C-5 of the ribose ring is mono-, di-, tri- or tetra-phosphorylated." [] synonym: "C5H9O6PR2" RELATED FORMULA [ChEBI:] synonym: "Nucleoside 5'-phosphate" EXACT [KEGG COMPOUND:] synonym: "nucleoside 5'-phosphates" RELATED [ChEBI:] synonym: "O[C@H]1[C@@H]([*])[C@H]([*])O[C@@H]1COP(O)(O)=O" RELATED SMILES [ChEBI:] xref: KEGG COMPOUND:C01117 "KEGG COMPOUND" is_a: CHEBI:29075 ! mononucleotide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16708 name: adenine namespace: chebi_ontology alt_id: CHEBI:13733 alt_id: CHEBI:22236 alt_id: CHEBI:2470 alt_id: CHEBI:40579 def: "The parent compound of the 6-aminopurines, composed of a purine having an amino group at C-6." [] synonym: "6-Aminopurine" RELATED [KEGG COMPOUND:] synonym: "9H-purin-6-amine" EXACT IUPAC_NAME [IUPAC:] synonym: "9H-purin-6-amine" RELATED [PDBeChem:] synonym: "A" RELATED [ChEBI:] synonym: "Ade" RELATED [CBN:] synonym: "Adenin" RELATED [NIST Chemistry WebBook:] synonym: "ADENINE" EXACT [PDBeChem:] synonym: "Adenine" EXACT [KEGG COMPOUND:] synonym: "adenine" EXACT [UniProt:] synonym: "C5H5N5" RELATED FORMULA [KEGG COMPOUND:] synonym: "InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10)" RELATED InChI [ChEBI:] synonym: "InChIKey=GFFGJBXGBJISGV-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "Nc1ncnc2[nH]cnc12" RELATED SMILES [ChEBI:] xref: Beilstein:608603 "Beilstein Registry Number" xref: ChemIDplus:73-24-5 "CAS Registry Number" xref: CiteXplore:17439666 "PubMed citation" xref: CiteXplore:8070089 "PubMed citation" xref: DrugBank:DB00173 "DrugBank" xref: Gmelin:3903 "Gmelin Registry Number" xref: HMDB:HMDB00034 "HMDB" xref: KEGG COMPOUND:73-24-5 "CAS Registry Number" xref: KEGG COMPOUND:C00147 "KEGG COMPOUND" xref: KEGG DRUG:D00034 "KEGG DRUG" xref: KNApSAcK:C00001490 "KNApSAcK" xref: MetaCyc:ADENINE "MetaCyc" xref: NIST Chemistry WebBook:73-24-5 "CAS Registry Number" xref: PDBeChem:ADE "PDBeChem" xref: Reaxys:608603 "Reaxys Registry Number" xref: Wikipedia:Adenine "Wikipedia" is_a: CHEBI:20706 ! 6-aminopurines is_a: CHEBI:26386 ! purine nucleobase property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16709 name: pyridoxine namespace: chebi_ontology alt_id: CHEBI:14981 alt_id: CHEBI:26429 alt_id: CHEBI:8671 def: "A hydroxymethylpyridine with hydroxymethyl groups at positions 4 and 5, a hydroxy group at position 3 and a methyl group at position 2." [] synonym: "2-methyl-3-hydroxy-4,5-dihydroxymethylpyridine" RELATED [NIST Chemistry WebBook:] synonym: "3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine" RELATED [ChEBI:] synonym: "3-hydroxy-4,5-dimethylol-alpha-picoline" RELATED [NIST Chemistry WebBook:] synonym: "4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol" EXACT IUPAC_NAME [IUPAC:] synonym: "5-hydroxy-6-methyl-3,4-pyridinedimethanol" RELATED [NIST Chemistry WebBook:] synonym: "C8H11NO3" RELATED FORMULA [KEGG COMPOUND:] synonym: "Cc1ncc(CO)c(CO)c1O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C8H11NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,10-12H,3-4H2,1H3" RELATED InChI [ChEBI:] synonym: "InChIKey=LXNHXLLTXMVWPM-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "Pyridoxine" EXACT [KEGG COMPOUND:] synonym: "pyridoxine" EXACT [UniProt:] synonym: "Pyridoxol" RELATED [KEGG COMPOUND:] synonym: "vitamin B6" RELATED [NIST Chemistry WebBook:] xref: Beilstein:139854 "Beilstein Registry Number" xref: ChemIDplus:65-23-6 "CAS Registry Number" xref: CiteXplore:24035968 "PubMed citation" xref: DrugBank:DB00165 "DrugBank" xref: Gmelin:563676 "Gmelin Registry Number" xref: HMDB:HMDB00239 "HMDB" xref: KEGG COMPOUND:65-23-6 "CAS Registry Number" xref: KEGG COMPOUND:C00314 "KEGG COMPOUND" xref: KEGG DRUG:D08454 "KEGG DRUG" xref: KNApSAcK:C00001551 "KNApSAcK" xref: NIST Chemistry WebBook:65-23-6 "CAS Registry Number" xref: Reaxys:139854 "Reaxys Registry Number" xref: Wikipedia:Pyridoxine "Wikipedia" is_a: CHEBI:25340 ! methylpyridines is_a: CHEBI:27306 ! vitamin B6 is_a: CHEBI:38182 ! monohydroxypyridine is_a: CHEBI:38196 ! hydroxymethylpyridine property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16811 name: methionine namespace: chebi_ontology alt_id: CHEBI:14590 alt_id: CHEBI:25229 alt_id: CHEBI:6829 def: "A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4." [] synonym: "2-amino-4-(methylsulfanyl)butanoic acid" RELATED [IUPAC:] synonym: "2-amino-4-(methylthio)butanoic acid" RELATED [JCBN:] synonym: "2-Amino-4-(methylthio)butyric acid" RELATED [KEGG COMPOUND:] synonym: "alpha-amino-gamma-methylmercaptobutyric acid" RELATED [NIST Chemistry WebBook:] synonym: "C5H11NO2S" RELATED FORMULA [KEGG COMPOUND:] synonym: "CSCCC(N)C(O)=O" RELATED SMILES [ChEBI:] synonym: "DL-Methionine" RELATED [KEGG DRUG:] synonym: "Hmet" RELATED [IUPAC:] synonym: "InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)" RELATED InChI [ChEBI:] synonym: "InChIKey=FFEARJCKVFRZRR-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "M" RELATED [ChEBI:] synonym: "Met" RELATED [ChEBI:] synonym: "Methionin" RELATED [ChEBI:] synonym: "Methionine" EXACT [KEGG COMPOUND:] synonym: "methionine" EXACT [ChEBI:] synonym: "methionine" EXACT IUPAC_NAME [IUPAC:] synonym: "metionina" RELATED [ChEBI:] synonym: "Racemethionine" RELATED [KEGG DRUG:] xref: Beilstein:636185 "Beilstein Registry Number" xref: ChemIDplus:59-51-8 "CAS Registry Number" xref: CiteXplore:16702333 "PubMed citation" xref: CiteXplore:22264337 "PubMed citation" xref: CiteXplore:2543976 "PubMed citation" xref: Gmelin:3117 "Gmelin Registry Number" xref: KEGG COMPOUND:59-51-8 "CAS Registry Number" xref: KEGG COMPOUND:C01733 "KEGG COMPOUND" xref: KEGG DRUG:D04983 "KEGG DRUG" xref: NIST Chemistry WebBook:59-51-8 "CAS Registry Number" xref: Reaxys:636185 "Reaxys Registry Number" xref: UM-BBD:c0094 "UM-BBD compID" xref: Wikipedia:Methionine "Wikipedia" is_a: CHEBI:26834 ! sulfur-containing amino acid is_a: CHEBI:33704 ! alpha-amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16828 name: L-tryptophan namespace: chebi_ontology alt_id: CHEBI:13178 alt_id: CHEBI:184633 alt_id: CHEBI:21407 alt_id: CHEBI:45988 alt_id: CHEBI:46086 alt_id: CHEBI:46125 alt_id: CHEBI:46225 alt_id: CHEBI:6310 def: "The L-enantiomer of tryptophan." [] synonym: "(2S)-2-amino-3-(1H-indol-3-yl)propanoic acid" RELATED [IUPAC:] synonym: "(S)-alpha-amino-1H-indole-3-propanoic acid" RELATED [NIST Chemistry WebBook:] synonym: "(S)-alpha-Amino-beta-(3-indolyl)-propionic acid" RELATED [KEGG COMPOUND:] synonym: "(S)-tryptophan" RELATED [NIST Chemistry WebBook:] synonym: "C11H12N2O2" RELATED FORMULA [KEGG COMPOUND:] synonym: "InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=QIVBCDIJIAJPQS-VIFPVBQESA-N" RELATED InChIKey [ChEBI:] synonym: "L-(-)-tryptophan" RELATED [NIST Chemistry WebBook:] synonym: "L-beta-3-indolylalanine" RELATED [NIST Chemistry WebBook:] synonym: "L-Tryptophan" EXACT [KEGG COMPOUND:] synonym: "L-tryptophan" EXACT [ChEBI:] synonym: "L-tryptophan" EXACT IUPAC_NAME [IUPAC:] synonym: "N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O" RELATED SMILES [ChEBI:] synonym: "Trp" RELATED [ChEBI:] synonym: "TRYPTOPHAN" RELATED [PDBeChem:] synonym: "Tryptophan" RELATED [KEGG COMPOUND:] synonym: "tryptophan" RELATED INN [KEGG DRUG:] synonym: "W" RELATED [ChEBI:] xref: Beilstein:86197 "Beilstein Registry Number" xref: ChemIDplus:73-22-3 "CAS Registry Number" xref: CiteXplore:11395471 "PubMed citation" xref: CiteXplore:11750787 "PubMed citation" xref: CiteXplore:11888576 "PubMed citation" xref: CiteXplore:12766158 "PubMed citation" xref: CiteXplore:12830226 "PubMed citation" xref: CiteXplore:12871129 "PubMed citation" xref: CiteXplore:15206750 "PubMed citation" xref: CiteXplore:16740930 "PubMed citation" xref: CiteXplore:16934873 "PubMed citation" xref: CiteXplore:17127472 "PubMed citation" xref: CiteXplore:17177562 "PubMed citation" xref: CiteXplore:17430113 "PubMed citation" xref: CiteXplore:17585690 "PubMed citation" xref: CiteXplore:17690425 "PubMed citation" xref: CiteXplore:17826001 "PubMed citation" xref: CiteXplore:18234569 "PubMed citation" xref: CiteXplore:18419734 "PubMed citation" xref: CiteXplore:18949702 "PubMed citation" xref: CiteXplore:19896323 "PubMed citation" xref: CiteXplore:21856896 "PubMed citation" xref: CiteXplore:22071091 "PubMed citation" xref: CiteXplore:22162421 "PubMed citation" xref: CiteXplore:22299628 "PubMed citation" xref: CiteXplore:22386992 "PubMed citation" xref: CiteXplore:22402312 "PubMed citation" xref: CiteXplore:22415302 "PubMed citation" xref: CiteXplore:22415306 "PubMed citation" xref: CiteXplore:2917974 "PubMed citation" xref: DrugBank:DB00150 "DrugBank" xref: ECMDB:ECMDB00929 "ECMDB" xref: Gmelin:51434 "Gmelin Registry Number" xref: HMDB:HMDB00929 "HMDB" xref: KEGG COMPOUND:73-22-3 "CAS Registry Number" xref: KEGG COMPOUND:C00078 "KEGG COMPOUND" xref: KEGG DRUG:D00020 "KEGG DRUG" xref: KNApSAcK:C00001396 "KNApSAcK" xref: MetaCyc:TRP "MetaCyc" xref: NIST Chemistry WebBook:73-22-3 "CAS Registry Number" xref: PDBeChem:TRP "PDBeChem" xref: PDBeChem:TRP_LEO2 "PDBeChem" xref: PDBeChem:TRP_LFOH "PDBeChem" xref: PDBeChem:TRP_LL "PDBeChem" xref: PDBeChem:TRP_LSN3 "PDBeChem" xref: Reaxys:86197 "Reaxys Registry Number" xref: Wikipedia:Tryptophan "Wikipedia" xref: YMDB:YMDB00126 "YMDB" is_a: CHEBI:27897 ! tryptophan is_a: CHEBI:73690 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid is_a: CHEBI:83813 ! proteinogenic amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16830 name: methylamine namespace: chebi_ontology alt_id: CHEBI:14595 alt_id: CHEBI:25402 alt_id: CHEBI:44374 alt_id: CHEBI:6864 def: "The simplest of the methylamines, consisting of ammonia bearing a single methyl substituent." [] synonym: "aminomethane" RELATED [NIST Chemistry WebBook:] synonym: "CH3-NH2" RELATED [IUPAC:] synonym: "CH5N" RELATED FORMULA [KEGG COMPOUND:] synonym: "CN" RELATED SMILES [ChEBI:] synonym: "InChI=1S/CH5N/c1-2/h2H2,1H3" RELATED InChI [ChEBI:] synonym: "InChIKey=BAVYZALUXZFZLV-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "MeNH2" RELATED [ChEBI:] synonym: "Methanamine" RELATED [KEGG COMPOUND:] synonym: "methanamine" EXACT IUPAC_NAME [IUPAC:] synonym: "METHYLAMINE" EXACT [PDBeChem:] synonym: "Methylamine" EXACT [KEGG COMPOUND:] synonym: "monomethylamine" RELATED [NIST Chemistry WebBook:] xref: Beilstein:741851 "Beilstein Registry Number" xref: ChemIDplus:74-89-5 "CAS Registry Number" xref: CiteXplore:11580915 "PubMed citation" xref: CiteXplore:11991665 "PubMed citation" xref: CiteXplore:18312416 "PubMed citation" xref: DrugBank:DB01828 "DrugBank" xref: Gmelin:145 "Gmelin Registry Number" xref: HMDB:HMDB00164 "HMDB" xref: KEGG COMPOUND:74-89-5 "CAS Registry Number" xref: KEGG COMPOUND:C00218 "KEGG COMPOUND" xref: MetaCyc:METHYLAMINE "MetaCyc" xref: NIST Chemistry WebBook:74-89-5 "CAS Registry Number" xref: PDBeChem:NC "PDBeChem" xref: PDBeChem:NME "PDBeChem" xref: Reaxys:741851 "Reaxys Registry Number" xref: UM-BBD:c0137 "UM-BBD compID" xref: Wikipedia:Methylamine "Wikipedia" is_a: CHEBI:17062 ! primary aliphatic amine is_a: CHEBI:25274 ! methylamines is_a: CHEBI:64708 ! one-carbon compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:168396 name: mycophenolic acid namespace: chebi_ontology alt_id: CHEBI:43973 def: "A member of the class of 2-benzofurans that is 2-benzofuran-1(3H)-one which is substituted at positions 4, 5, 6, and 7 by methyl, methoxy, (2E)-5-carboxy-3-methylpent-2-en-1-yl, and hydroxy groups, respectively. It is an antibiotic produced by Penicillium brevi-compactum, P. stoloniferum, P. echinulatum and related species. An immunosuppressant, it is widely used (partiularly as its sodium salt and as the 2-(morpholin-4-yl)ethyl ester prodrug, mycophenolate mofetil) to prevent tissue rejection following organ transplants and for the treatment of certain autoimmune diseases." [] synonym: "(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "(E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid" RELATED [ChemIDplus:] synonym: "acide mycophenolique" RELATED INN [ChemIDplus:] synonym: "acido micofenolico" RELATED INN [ChemIDplus:] synonym: "acidum mycophenolicum" RELATED INN [ChemIDplus:] synonym: "C17H20O6" RELATED FORMULA [ChEBI:] synonym: "COc1c(C)c2COC(=O)c2c(O)c1C\\C=C(/C)CCC(O)=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+" RELATED InChI [ChEBI:] synonym: "InChIKey=HPNSFSBZBAHARI-RUDMXATFSA-N" RELATED InChIKey [ChEBI:] synonym: "Micofenolico acido" RELATED [ChemIDplus:] synonym: "Mycophenolate" RELATED [ChemIDplus:] synonym: "MYCOPHENOLIC ACID" EXACT [PDBeChem:] synonym: "mycophenolic acid" RELATED INN [KEGG DRUG:] synonym: "Mycophenolsaeure" RELATED [ChemIDplus:] xref: Beilstein:318158 "Beilstein Registry Number" xref: ChemIDplus:24280-93-1 "CAS Registry Number" xref: CiteXplore:11272311 "PubMed citation" xref: CiteXplore:15470161 "PubMed citation" xref: CiteXplore:16629948 "PubMed citation" xref: CiteXplore:16640327 "PubMed citation" xref: CiteXplore:17482154 "PubMed citation" xref: CiteXplore:17498396 "PubMed citation" xref: CiteXplore:18194117 "PubMed citation" xref: CiteXplore:18611107 "PubMed citation" xref: CiteXplore:18996104 "PubMed citation" xref: CiteXplore:19689217 "PubMed citation" xref: DrugBank:24280-93-1 "CAS Registry Number" xref: DrugBank:DB01024 "DrugBank" xref: KEGG DRUG:24280-93-1 "CAS Registry Number" xref: KEGG DRUG:D05096 "KEGG DRUG" xref: Patent:US4753935 "Patent" xref: PDBeChem:MOA "PDBeChem" xref: Reaxys:318158 "Reaxys Registry Number" xref: Wikipedia:Mycophenolic_acid "Wikipedia" is_a: CHEBI:25384 ! monocarboxylic acid is_a: CHEBI:33853 ! phenols is_a: CHEBI:37581 ! gamma-lactone is_a: CHEBI:38831 ! 2-benzofurans property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16856 name: glutathione namespace: chebi_ontology alt_id: CHEBI:12402 alt_id: CHEBI:14327 alt_id: CHEBI:24334 alt_id: CHEBI:42873 alt_id: CHEBI:43049 alt_id: CHEBI:5437 def: "A tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine." [] synonym: "5-L-Glutamyl-L-cysteinylglycine" RELATED [KEGG COMPOUND:] synonym: "C10H17N3O6S" RELATED FORMULA [KEGG COMPOUND:] synonym: "gamma-L-Glutamyl-L-cysteinyl-glycine" RELATED [KEGG COMPOUND:] synonym: "Glutathione" EXACT [KEGG COMPOUND:] synonym: "Glutathione-SH" RELATED [HMDB:] synonym: "GSH" RELATED [KEGG COMPOUND:] synonym: "InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/t5-,6-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=RWSXRVCMGQZWBV-WDSKDSINSA-N" RELATED InChIKey [ChEBI:] synonym: "L-gamma-glutamyl-L-cysteinylglycine" EXACT IUPAC_NAME [IUPAC:] synonym: "L-gamma-glutamyl-L-cysteinylglycine" RELATED [PDBeChem:] synonym: "N-(N-gamma-L-Glutamyl-L-cysteinyl)glycine" RELATED [KEGG COMPOUND:] synonym: "N-[(4S)-4-ammonio-4-carboxybutanoyl]-L-cysteinylglycine" RELATED [PDBeChem:] synonym: "N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O" RELATED SMILES [ChEBI:] synonym: "Reduced glutathione" RELATED [KEGG COMPOUND:] xref: ChemIDplus:70-18-8 "CAS Registry Number" xref: CiteXplore:17439666 "PubMed citation" xref: CiteXplore:4200890 "PubMed citation" xref: CiteXplore:4745654 "PubMed citation" xref: DrugBank:DB00143 "DrugBank" xref: HMDB:HMDB00125 "HMDB" xref: KEGG COMPOUND:70-18-8 "CAS Registry Number" xref: KEGG COMPOUND:C00051 "KEGG COMPOUND" xref: KEGG DRUG:D00014 "KEGG DRUG" xref: KNApSAcK:C00001518 "KNApSAcK" xref: MetaCyc:GLUTATHIONE "MetaCyc" xref: PDBeChem:GSH "PDBeChem" xref: PDBeChem:GTT "PDBeChem" xref: Reaxys:1729812 "Reaxys Registry Number" xref: Wikipedia:Glutathione "Wikipedia" is_a: CHEBI:29256 ! thiol is_a: CHEBI:47923 ! tripeptide is_a: CHEBI:83824 ! L-cysteine derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16857 name: L-threonine namespace: chebi_ontology alt_id: CHEBI:13175 alt_id: CHEBI:21403 alt_id: CHEBI:42083 alt_id: CHEBI:45843 alt_id: CHEBI:45983 alt_id: CHEBI:6308 def: "An optically active form of threonine having L-configuration." [] synonym: "(2S)-threonine" RELATED [ChemIDplus:] synonym: "(2S,3R)-(-)-Threonine" RELATED [HMDB:] synonym: "(2S,3R)-2-amino-3-hydroxybutanoic acid" RELATED [IUPAC:] synonym: "2-Amino-3-hydroxybutyric acid" RELATED [KEGG COMPOUND:] synonym: "C4H9NO3" RELATED FORMULA [KEGG COMPOUND:] synonym: "C[C@@H](O)[C@H](N)C(O)=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=AYFVYJQAPQTCCC-GBXIJSLDSA-N" RELATED InChIKey [ChEBI:] synonym: "L-(-)-Threonine" RELATED [DrugBank:] synonym: "L-2-Amino-3-hydroxybutyric acid" RELATED [HMDB:] synonym: "L-alpha-amino-beta-hydroxybutyric acid" RELATED [NIST Chemistry WebBook:] synonym: "L-Threonin" RELATED [ChEBI:] synonym: "L-Threonine" EXACT [PDBeChem:] synonym: "L-Threonine" EXACT [KEGG COMPOUND:] synonym: "L-threonine" EXACT IUPAC_NAME [IUPAC:] synonym: "T" RELATED [ChEBI:] synonym: "Thr" RELATED [ChEBI:] synonym: "THREONINE" RELATED [PDBeChem:] xref: Beilstein:1721646 "Beilstein Registry Number" xref: ChemIDplus:72-19-5 "CAS Registry Number" xref: CiteXplore:11964235 "PubMed citation" xref: CiteXplore:12523390 "PubMed citation" xref: CiteXplore:16659349 "PubMed citation" xref: CiteXplore:17379183 "PubMed citation" xref: CiteXplore:22289691 "PubMed citation" xref: CiteXplore:22342587 "PubMed citation" xref: CiteXplore:22513921 "PubMed citation" xref: CiteXplore:22770225 "PubMed citation" xref: CiteXplore:24671569 "PubMed citation" xref: DrugBank:DB00156 "DrugBank" xref: ECMDB:ECMDB00167 "ECMDB" xref: Gmelin:82510 "Gmelin Registry Number" xref: HMDB:HMDB00167 "HMDB" xref: KEGG COMPOUND:72-19-5 "CAS Registry Number" xref: KEGG COMPOUND:C00188 "KEGG COMPOUND" xref: KEGG DRUG:D00041 "KEGG DRUG" xref: KNApSAcK:C00001394 "KNApSAcK" xref: NIST Chemistry WebBook:72-19-5 "CAS Registry Number" xref: PDBeChem:THR "PDBeChem" xref: Reaxys:1721646 "Reaxys Registry Number" xref: UM-BBD:c0413 "UM-BBD compID" xref: Wikipedia:Threonine "Wikipedia" xref: YMDB:YMDB00214 "YMDB" is_a: CHEBI:22658 ! aspartate family amino acid is_a: CHEBI:26986 ! threonine is_a: CHEBI:83813 ! proteinogenic amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16862 name: nucleoside diphosphate namespace: chebi_ontology alt_id: CHEBI:13401 alt_id: CHEBI:13662 alt_id: CHEBI:14675 alt_id: CHEBI:25606 alt_id: CHEBI:7428 alt_id: CHEBI:7652 synonym: "C5H11O10P2R" RELATED FORMULA [ChEBI:] synonym: "NDP" RELATED [KEGG COMPOUND:] synonym: "Nucleoside diphosphate" EXACT [KEGG COMPOUND:] synonym: "nucleoside diphosphates" RELATED [ChEBI:] synonym: "O[C@H]1[C@H]([*])O[C@H](COP(O)(=O)OP(O)(O)=O)[C@H]1O" RELATED SMILES [ChEBI:] xref: KEGG COMPOUND:C00454 "KEGG COMPOUND" is_a: CHEBI:25608 ! nucleoside phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16907 name: 4-nitroquinoline N-oxide namespace: chebi_ontology alt_id: CHEBI:12037 alt_id: CHEBI:1917 alt_id: CHEBI:20460 alt_id: CHEBI:57944 def: "A quinoline N-oxide carrying a nitro substituent at position 4." [] synonym: "4-Nitroquinoline 1-oxide" RELATED [KEGG COMPOUND:] synonym: "4-nitroquinoline 1-oxide" EXACT IUPAC_NAME [IUPAC:] synonym: "4-nitroquinoline 1-oxide" RELATED [ChEBI:] synonym: "4-Nitroquinoline N-oxide" EXACT [KEGG COMPOUND:] synonym: "4-nitroquinoline N-oxide" EXACT [ChEBI:] synonym: "4-nitroquinoline N-oxide" EXACT [UniProt:] synonym: "4-Nitroquinoline-1-oxide" RELATED [ChemIDplus:] synonym: "4-Nitroquinoline-N-oxide" RELATED [ChemIDplus:] synonym: "[O-][N+](=O)c1cc[n+]([O-])c2ccccc12" RELATED SMILES [ChEBI:] synonym: "C9H6N2O3" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C9H6N2O3/c12-10-6-5-9(11(13)14)7-3-1-2-4-8(7)10/h1-6H" RELATED InChI [ChEBI:] synonym: "InChIKey=YHQDZJICGQWFHK-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "Nitrochin" RELATED [NIST Chemistry WebBook:] xref: CiteXplore:16448841 "PubMed citation" xref: CiteXplore:24105297 "PubMed citation" xref: KEGG COMPOUND:56-57-5 "CAS Registry Number" xref: KEGG COMPOUND:C03474 "KEGG COMPOUND" xref: NIST Chemistry WebBook:56-57-5 "CAS Registry Number" xref: Reaxys:165756 "Reaxys Registry Number" xref: Wikipedia:4-Nitroquinoline_1-oxide "Wikipedia" is_a: CHEBI:26508 ! quinoline N-oxide is_a: CHEBI:35716 ! C-nitro compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16916 name: oligosaccharide phosphate namespace: chebi_ontology alt_id: CHEBI:14693 alt_id: CHEBI:25677 alt_id: CHEBI:7760 def: "An oligosaccharide derivative in which at least one hydroxy group has been phosphorylated." [] synonym: "CC(=O)N[C@@H]1[C@@H](O)[C@H](O[*])[C@@H](CO)O[C@H]1O[C@H]1[C@H](O)[C@@H](NC(C)=O)[C@@H](OP(O)(O)=O)O[C@@H]1CO" RELATED SMILES [ChEBI:] synonym: "Oligosaccharide phosphate" EXACT [KEGG COMPOUND:] synonym: "oligosaccharide phosphate" EXACT [UniProt:] synonym: "oligosaccharide phosphates" RELATED [ChEBI:] is_a: CHEBI:26816 ! carbohydrate phosphate is_a: CHEBI:63563 ! oligosaccharide derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16933 name: ergosterol namespace: chebi_ontology alt_id: CHEBI:14214 alt_id: CHEBI:23942 alt_id: CHEBI:42264 alt_id: CHEBI:4825 def: "A phytosterol consiting of ergostane having double bonds at the 5,6-, 7,8- and 22,23-positions as well as a 3beta-hydroxy group." [] synonym: "(22E)-ergosta-5,7,22-trien-3beta-ol" EXACT IUPAC_NAME [IUPAC:] synonym: "(22E,24S)-24-methylcholesta-5,7,22-trien-3beta-ol" RELATED [JCBN:] synonym: "(3beta,14beta,17alpha,22E)-ergosta-5,7,22-trien-3-ol" RELATED [PDBeChem:] synonym: "24alpha-Methyl-22E-dehydrocholesterol" RELATED [ChEBI:] synonym: "24R-Methylcholesta-5,7,2E-trien-3beta-ol" RELATED [ChEBI:] synonym: "[H][C@@]1(CC[C@@]2([H])C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)\\C=C\\[C@H](C)C(C)C" RELATED SMILES [ChEBI:] synonym: "C28H44O" RELATED FORMULA [KEGG COMPOUND:] synonym: "Ergosta-5,7,22-trien-3-ol, (3beta,22E)-" RELATED [ChEBI:] synonym: "Ergosta-5,7,22-trien-3beta-ol" RELATED [ChEBI:] synonym: "Ergosterin" RELATED [ChEBI:] synonym: "ERGOSTEROL" EXACT [PDBeChem:] synonym: "Ergosterol" EXACT [KEGG COMPOUND:] synonym: "ergosterol" EXACT [UniProt:] synonym: "InChI=1S/C28H44O/c1-18(2)19(3)7-8-20(4)24-11-12-25-23-10-9-21-17-22(29)13-15-27(21,5)26(23)14-16-28(24,25)6/h7-10,18-20,22,24-26,29H,11-17H2,1-6H3/b8-7+/t19-,20+,22-,24+,25-,26-,27-,28+/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=DNVPQKQSNYMLRS-APGDWVJJSA-N" RELATED InChIKey [ChEBI:] synonym: "Provitamin D2" RELATED [KEGG COMPOUND:] xref: Beilstein:2338604 "Beilstein Registry Number" xref: ChemIDplus:57-87-4 "CAS Registry Number" xref: Chemspider:392539 "Chemspider" xref: CiteXplore:12357398 "PubMed citation" xref: CiteXplore:19663417 "PubMed citation" xref: CiteXplore:21043476 "PubMed citation" xref: CiteXplore:21244021 "PubMed citation" xref: CiteXplore:21341709 "PubMed citation" xref: CiteXplore:21428374 "PubMed citation" xref: CiteXplore:21848266 "PubMed citation" xref: CiteXplore:21995505 "PubMed citation" xref: CiteXplore:22004007 "PubMed citation" xref: CiteXplore:c6148 "CiteXplore citation" xref: DrugBank:DB04038 "DrugBank" xref: KEGG COMPOUND:57-87-4 "CAS Registry Number" xref: KEGG COMPOUND:C01694 "KEGG COMPOUND" xref: KNApSAcK:C00003652 "KNApSAcK" xref: KNApSAcK:C00023755 "KNApSAcK" xref: LIPID MAPS:LMST01030093 "LIPID MAPS instance" xref: NIST Chemistry WebBook:57-87-4 "CAS Registry Number" xref: PDBeChem:ERG "PDBeChem" xref: Reaxys:2338604 "Reaxys Registry Number" is_a: CHEBI:26125 ! phytosterols is_a: CHEBI:35348 ! 3beta-sterol is_a: CHEBI:50403 ! ergostanoid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16966 name: heteroglycan namespace: chebi_ontology alt_id: CHEBI:14394 alt_id: CHEBI:24534 alt_id: CHEBI:5688 def: "A polysaccharide composed of two or more different types of monosaccharides," [] synonym: "Heteroglycan" EXACT [KEGG COMPOUND:] synonym: "heteroglycans" RELATED [ChEBI:] synonym: "Heteropolysaccharide" RELATED [KEGG COMPOUND:] xref: KEGG COMPOUND:C01923 "KEGG COMPOUND" is_a: CHEBI:18154 ! polysaccharide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16976 name: hygromycin B namespace: chebi_ontology alt_id: CHEBI:14426 alt_id: CHEBI:24752 alt_id: CHEBI:43202 alt_id: CHEBI:5821 def: "A hygromycin that has formula C20H37N3O13." [] synonym: "(1R,2S,3R,5S,6R)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1->2-3)-beta-D-talopyranoside" EXACT IUPAC_NAME [IUPAC:] synonym: "Antibiotic A-396-II" RELATED [KEGG COMPOUND:] synonym: "C20H37N3O13" RELATED FORMULA [KEGG COMPOUND:] synonym: "CN[C@H]1C[C@@H](N)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@@H]3O[C@@]4(O[C@H](C(N)CO)[C@H](O)[C@H](O)[C@H]4O)O[C@H]23)[C@@H]1O" RELATED SMILES [ChEBI:] synonym: "HYGROMYCIN B" EXACT [PDBeChem:] synonym: "Hygromycin B" EXACT [KEGG COMPOUND:] synonym: "InChI=1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6?,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=GRRNUXAQVGOGFE-NZSRVPFOSA-N" RELATED InChIKey [ChEBI:] synonym: "O-6-amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1->2-3)-O-beta-D-talopyranosyl-(1->5)-2-deoxy-N(3)-methyl-D-streptamine" RELATED [ChEBI:] xref: Beilstein:6755837 "Beilstein Registry Number" xref: ChemIDplus:31282-04-9 "CAS Registry Number" xref: KEGG COMPOUND:31282-04-9 "CAS Registry Number" xref: KEGG COMPOUND:C01925 "KEGG COMPOUND" xref: PDBeChem:HYG "PDBeChem" is_a: CHEBI:24753 ! hygromycin is_a: CHEBI:71989 ! ortho ester property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16977 name: L-alanine namespace: chebi_ontology alt_id: CHEBI:13069 alt_id: CHEBI:21216 alt_id: CHEBI:40734 alt_id: CHEBI:40735 alt_id: CHEBI:46308 alt_id: CHEBI:6171 def: "The L-enantiomer of alanine." [] synonym: "(2S)-2-aminopropanoic acid" RELATED [IUPAC:] synonym: "(S)-2-aminopropanoic acid" RELATED [ChEBI:] synonym: "(S)-alanine" RELATED [NIST Chemistry WebBook:] synonym: "A" RELATED [ChEBI:] synonym: "Ala" RELATED [NIST Chemistry WebBook:] synonym: "ALANINE" RELATED [PDBeChem:] synonym: "C3H7NO2" RELATED FORMULA [KEGG COMPOUND:] synonym: "C[C@H](N)C(O)=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=QNAYBMKLOCPYGJ-REOHCLBHSA-N" RELATED InChIKey [ChEBI:] synonym: "L-2-Aminopropionic acid" RELATED [KEGG COMPOUND:] synonym: "L-Alanin" RELATED [ChEBI:] synonym: "L-Alanine" EXACT [KEGG COMPOUND:] synonym: "L-Alanine" EXACT [PDBeChem:] synonym: "L-alanine" EXACT IUPAC_NAME [IUPAC:] synonym: "L-alpha-Alanine" RELATED [KEGG COMPOUND:] synonym: "L-alpha-alanine" RELATED [NIST Chemistry WebBook:] xref: Beilstein:1720248 "Beilstein Registry Number" xref: ChemIDplus:56-41-7 "CAS Registry Number" xref: CiteXplore:18235971 "PubMed citation" xref: CiteXplore:22735334 "PubMed citation" xref: CiteXplore:3275662 "PubMed citation" xref: DrugBank:DB00160 "DrugBank" xref: ECMDB:ECMDB00161 "ECMDB" xref: Gmelin:49628 "Gmelin Registry Number" xref: HMDB:HMDB00161 "HMDB" xref: KEGG COMPOUND:56-41-7 "CAS Registry Number" xref: KEGG COMPOUND:C00041 "KEGG COMPOUND" xref: KEGG DRUG:D00012 "KEGG DRUG" xref: KNApSAcK:C00001332 "KNApSAcK" xref: MetaCyc:ALPHA-ALANINE "MetaCyc" xref: NIST Chemistry WebBook:56-41-7 "CAS Registry Number" xref: PDBeChem:ALA_LFOH "PDBeChem" xref: PDBeChem:ALA_LSN3 "PDBeChem" xref: Reaxys:1720248 "Reaxys Registry Number" xref: Wikipedia:Alanine "Wikipedia" xref: YMDB:YMDB00154 "YMDB" is_a: CHEBI:16449 ! alanine is_a: CHEBI:26463 ! pyruvate family amino acid is_a: CHEBI:83813 ! proteinogenic amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:16991 name: deoxyribonucleic acid namespace: chebi_ontology alt_id: CHEBI:13302 alt_id: CHEBI:21123 alt_id: CHEBI:33698 alt_id: CHEBI:4291 def: "High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms." [] synonym: "(Deoxyribonucleotide)m" RELATED [KEGG COMPOUND:] synonym: "(Deoxyribonucleotide)n" RELATED [KEGG COMPOUND:] synonym: "(Deoxyribonucleotide)n+m" RELATED [KEGG COMPOUND:] synonym: "." RELATED FORMULA [ChEBI:] synonym: "C10H17O8PR2(C5H8O5PR)n" RELATED FORMULA [KEGG COMPOUND:] synonym: "Deoxyribonucleic acid" EXACT [KEGG COMPOUND:] synonym: "deoxyribonucleic acids" EXACT IUPAC_NAME [IUPAC:] synonym: "deoxyribonucleic acids" RELATED [ChEBI:] synonym: "Desoxyribonukleinsaeure" RELATED [ChEBI:] synonym: "desoxyribose nucleic acid" RELATED [ChemIDplus:] synonym: "DNA" RELATED [KEGG COMPOUND:] synonym: "DNA" RELATED [IUPAC:] synonym: "DNAn" RELATED [KEGG COMPOUND:] synonym: "DNAn+1" RELATED [KEGG COMPOUND:] synonym: "DNS" RELATED [ChEBI:] synonym: "thymus nucleic acid" RELATED [ChEBI:] xref: ChemIDplus:9007-49-2 "CAS Registry Number" xref: KEGG COMPOUND:9007-49-2 "CAS Registry Number" xref: KEGG COMPOUND:C00039 "KEGG COMPOUND" is_a: CHEBI:33696 ! nucleic acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17016 name: L-methionine S-oxide namespace: chebi_ontology alt_id: CHEBI:13142 alt_id: CHEBI:21361 alt_id: CHEBI:6272 def: "A methionine S-oxide that has formula C5H11NO3S." [] synonym: "(2S)-2-amino-4-(methylsulfinyl)butanoic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "C5H11NO3S" RELATED FORMULA [KEGG COMPOUND:] synonym: "CS(=O)CC[C@H](N)C(O)=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C5H11NO3S/c1-10(9)3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-,10?/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=QEFRNWWLZKMPFJ-YGVKFDHGSA-N" RELATED InChIKey [ChEBI:] synonym: "L-Methionine S-oxide" EXACT [KEGG COMPOUND:] synonym: "L-methionine S-oxide" EXACT IUPAC_NAME [IUPAC:] synonym: "L-methionine S-oxide" EXACT [UniProt:] synonym: "L-methionine sulfoxide" RELATED [ChemIDplus:] synonym: "methionine S-oxide" RELATED [ChemIDplus:] xref: Beilstein:1723794 "Beilstein Registry Number" xref: ChemIDplus:3226-65-1 "CAS Registry Number" xref: KEGG COMPOUND:3226-65-1 "CAS Registry Number" xref: KEGG COMPOUND:C02989 "KEGG COMPOUND" is_a: CHEBI:49033 ! methionine S-oxide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17062 name: primary aliphatic amine namespace: chebi_ontology alt_id: CHEBI:13431 alt_id: CHEBI:8749 synonym: "CH4NR" RELATED FORMULA [ChEBI:] synonym: "NC[*]" RELATED SMILES [ChEBI:] synonym: "primary aliphatic amines" RELATED [ChEBI:] synonym: "RCH2NH2" RELATED [ChEBI:] synonym: "RCH2NH2" RELATED [KEGG COMPOUND:] xref: KEGG COMPOUND:C00375 "KEGG COMPOUND" is_a: CHEBI:32877 ! primary amine property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17087 name: ketone namespace: chebi_ontology alt_id: CHEBI:13427 alt_id: CHEBI:13646 alt_id: CHEBI:24974 alt_id: CHEBI:6127 alt_id: CHEBI:8742 def: "A compound in which a carbonyl group is bonded to two carbon atoms: R2C=O (neither R may be H)." [] synonym: "[*]C([*])=O" RELATED SMILES [ChEBI:] synonym: "a ketone" RELATED [UniProt:] synonym: "cetone" RELATED [ChEBI:] synonym: "COR2" RELATED FORMULA [ChEBI:] synonym: "Keton" RELATED [ChEBI:] synonym: "Ketone" EXACT [KEGG COMPOUND:] synonym: "ketones" EXACT IUPAC_NAME [IUPAC:] synonym: "ketones" RELATED [ChEBI:] synonym: "R-CO-R'" RELATED [KEGG COMPOUND:] xref: KEGG COMPOUND:C01450 "KEGG COMPOUND" xref: Wikipedia:Ketone "Wikipedia" is_a: CHEBI:36586 ! carbonyl compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17111 name: 5-O-phosphono-alpha-D-ribofuranosyl diphosphate namespace: chebi_ontology alt_id: CHEBI:12159 alt_id: CHEBI:12160 alt_id: CHEBI:20625 alt_id: CHEBI:2121 alt_id: CHEBI:45139 def: "A derivative of alpha-D-ribose having a phosphate group at the 5-position and a diphosphate at the 1-position." [] synonym: "5-O-phosphono-alpha-D-ribofuranose 1-(trihydrogen diphosphate)" EXACT IUPAC_NAME [IUPAC:] synonym: "5-Phospho-alpha-D-ribose 1-diphosphate" RELATED [KEGG COMPOUND:] synonym: "5-Phosphoribosyl 1-pyrophosphate" RELATED [KEGG COMPOUND:] synonym: "5-Phosphoribosyl diphosphate" RELATED [KEGG COMPOUND:] synonym: "alpha-D-ribofuranose 5-(dihydrogen phosphate) 1-(trihydrogen diphosphate)" RELATED [ChemIDplus:] synonym: "ALPHA-PHOSPHORIBOSYLPYROPHOSPHORIC ACID" RELATED [PDBeChem:] synonym: "C5H13O14P3" RELATED FORMULA [KEGG COMPOUND:] synonym: "InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/t2-,3-,4-,5-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=PQGCEDQWHSBAJP-TXICZTDVSA-N" RELATED InChIKey [ChEBI:] synonym: "O[C@H]1[C@@H](O)[C@H](O[C@@H]1COP(O)(O)=O)OP(O)(=O)OP(O)(O)=O" RELATED SMILES [ChEBI:] synonym: "phosphoribosyl pyrophosphate" RELATED [ChemIDplus:] synonym: "phosphoribosylpyrophosphate" RELATED [ChEBI:] synonym: "PRib-PP" RELATED [CBN:] synonym: "PRPP" RELATED [KEGG COMPOUND:] xref: Beilstein:60403 "Beilstein Registry Number" xref: ChemIDplus:7540-64-9 "CAS Registry Number" xref: CiteXplore:22264286 "PubMed citation" xref: CiteXplore:23509005 "PubMed citation" xref: CiteXplore:23734909 "PubMed citation" xref: DrugBank:DB01632 "DrugBank" xref: HMDB:HMDB00280 "HMDB" xref: KEGG COMPOUND:C00119 "KEGG COMPOUND" xref: KNApSAcK:C00007296 "KNApSAcK" xref: MetaCyc:PRPP "MetaCyc" xref: PDBeChem:PRP "PDBeChem" xref: Reaxys:60403 "Reaxys Registry Number" is_a: CHEBI:48956 ! 5-O-phosphono-D-ribofuranosyl diphosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17115 name: L-serine namespace: chebi_ontology alt_id: CHEBI:13167 alt_id: CHEBI:21387 alt_id: CHEBI:45440 alt_id: CHEBI:45451 alt_id: CHEBI:45590 alt_id: CHEBI:45597 alt_id: CHEBI:45677 alt_id: CHEBI:6301 def: "The L-enantiomer of serine." [] synonym: "(2S)-2-amino-3-hydroxypropanoic acid" RELATED [IUPAC:] synonym: "(S)-(-)-serine" RELATED [NIST Chemistry WebBook:] synonym: "(S)-2-amino-3-hydroxypropanoic acid" RELATED [NIST Chemistry WebBook:] synonym: "(S)-alpha-Amino-beta-hydroxypropionic acid" RELATED [HMDB:] synonym: "(S)-serine" RELATED [ChemIDplus:] synonym: "beta-Hydroxy-L-alanine" RELATED [HMDB:] synonym: "beta-Hydroxyalanine" RELATED [HMDB:] synonym: "C3H7NO3" RELATED FORMULA [KEGG COMPOUND:] synonym: "HYDROXYALANINE" RELATED [PDBeChem:] synonym: "InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=MTCFGRXMJLQNBG-REOHCLBHSA-N" RELATED InChIKey [ChEBI:] synonym: "L-(-)-serine" RELATED [NIST Chemistry WebBook:] synonym: "L-2-Amino-3-hydroxypropionic acid" RELATED [KEGG COMPOUND:] synonym: "L-3-Hydroxy-2-aminopropionic acid" RELATED [HMDB:] synonym: "L-3-Hydroxy-alanine" RELATED [KEGG COMPOUND:] synonym: "L-Ser" RELATED [DrugBank:] synonym: "L-Serin" RELATED [ChEBI:] synonym: "L-Serine" EXACT [KEGG COMPOUND:] synonym: "L-serine" EXACT IUPAC_NAME [IUPAC:] synonym: "N[C@@H](CO)C(O)=O" RELATED SMILES [ChEBI:] synonym: "S" RELATED [ChEBI:] synonym: "Ser" RELATED [ChEBI:] synonym: "SERINE" RELATED [PDBeChem:] synonym: "Serine" RELATED [KEGG COMPOUND:] xref: Beilstein:1721404 "Beilstein Registry Number" xref: ChemIDplus:56-45-1 "CAS Registry Number" xref: CiteXplore:1650428 "PubMed citation" xref: CiteXplore:17439666 "PubMed citation" xref: CiteXplore:19062365 "PubMed citation" xref: CiteXplore:21956576 "PubMed citation" xref: CiteXplore:22265470 "PubMed citation" xref: CiteXplore:22393170 "PubMed citation" xref: CiteXplore:22547037 "PubMed citation" xref: CiteXplore:22566084 "PubMed citation" xref: CiteXplore:22566694 "PubMed citation" xref: DrugBank:DB00133 "DrugBank" xref: ECMDB:ECMDB00187 "ECMDB" xref: Gmelin:2570 "Gmelin Registry Number" xref: HMDB:HMDB00187 "HMDB" xref: KEGG COMPOUND:56-45-1 "CAS Registry Number" xref: KEGG COMPOUND:C00065 "KEGG COMPOUND" xref: KEGG DRUG:D00016 "KEGG DRUG" xref: KNApSAcK:C00001393 "KNApSAcK" xref: MetaCyc:SER "MetaCyc" xref: NIST Chemistry WebBook:56-45-1 "CAS Registry Number" xref: PDBeChem:SER "PDBeChem" xref: Reaxys:1721404 "Reaxys Registry Number" xref: Wikipedia:L-serine "Wikipedia" xref: YMDB:YMDB00112 "YMDB" is_a: CHEBI:17822 ! serine is_a: CHEBI:26650 ! serine family amino acid is_a: CHEBI:83813 ! proteinogenic amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17154 name: nicotinamide namespace: chebi_ontology alt_id: CHEBI:14645 alt_id: CHEBI:25521 alt_id: CHEBI:44258 alt_id: CHEBI:7556 def: "A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group." [] synonym: "3-pyridinecarboxamide" RELATED [NIST Chemistry WebBook:] synonym: "beta-pyridinecarboxamide" RELATED [NIST Chemistry WebBook:] synonym: "C6H6N2O" RELATED FORMULA [KEGG COMPOUND:] synonym: "InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)" RELATED InChI [ChEBI:] synonym: "InChIKey=DFPAKSUCGFBDDF-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "NC(=O)c1cccnc1" RELATED SMILES [ChEBI:] synonym: "niacin" RELATED [ChEBI:] synonym: "Niacinamide" RELATED [KEGG COMPOUND:] synonym: "Nicotinamid" RELATED [ChEBI:] synonym: "NICOTINAMIDE" EXACT [PDBeChem:] synonym: "Nicotinamide" EXACT [KEGG COMPOUND:] synonym: "nicotinamide" EXACT [UniProt:] synonym: "Nicotinic acid amide" RELATED [KEGG COMPOUND:] synonym: "Nicotinsaeureamid" RELATED [ChEBI:] synonym: "Nikotinamid" RELATED [ChemIDplus:] synonym: "Nikotinsaeureamid" RELATED [ChEBI:] synonym: "pyridine-3-carboxamide" EXACT IUPAC_NAME [IUPAC:] synonym: "vitamin B3" RELATED [ChemIDplus:] synonym: "Vitamin PP" RELATED [KEGG COMPOUND:] xref: Beilstein:383619 "Beilstein Registry Number" xref: ChemIDplus:98-92-0 "CAS Registry Number" xref: CiteXplore:10884473 "PubMed citation" xref: CiteXplore:11355130 "PubMed citation" xref: CiteXplore:12014919 "PubMed citation" xref: CiteXplore:12519385 "PubMed citation" xref: CiteXplore:12782109 "PubMed citation" xref: CiteXplore:12890690 "PubMed citation" xref: CiteXplore:14729974 "PubMed citation" xref: CiteXplore:14871431 "PubMed citation" xref: CiteXplore:15497767 "PubMed citation" xref: CiteXplore:15780941 "PubMed citation" xref: CiteXplore:15995937 "PubMed citation" xref: CiteXplore:16871361 "PubMed citation" xref: CiteXplore:17021258 "PubMed citation" xref: CiteXplore:17129213 "PubMed citation" xref: CiteXplore:18234191 "PubMed citation" xref: CiteXplore:18316796 "PubMed citation" xref: CiteXplore:18368629 "PubMed citation" xref: CiteXplore:18373238 "PubMed citation" xref: CiteXplore:18389009 "PubMed citation" xref: CiteXplore:18514428 "PubMed citation" xref: CiteXplore:18930755 "PubMed citation" xref: CiteXplore:18987186 "PubMed citation" xref: CiteXplore:19539713 "PubMed citation" xref: CiteXplore:19544437 "PubMed citation" xref: CiteXplore:21503886 "PubMed citation" xref: CiteXplore:21891976 "PubMed citation" xref: CiteXplore:21918528 "PubMed citation" xref: CiteXplore:21926578 "PubMed citation" xref: CiteXplore:22067079 "PubMed citation" xref: CiteXplore:22160932 "PubMed citation" xref: CiteXplore:22207684 "PubMed citation" xref: CiteXplore:22232263 "PubMed citation" xref: CiteXplore:22281243 "PubMed citation" xref: CiteXplore:22359146 "PubMed citation" xref: CiteXplore:22361740 "PubMed citation" xref: CiteXplore:22407380 "PubMed citation" xref: CiteXplore:22456321 "PubMed citation" xref: CiteXplore:22536229 "PubMed citation" xref: CiteXplore:22543086 "PubMed citation" xref: CiteXplore:22699421 "PubMed citation" xref: CiteXplore:22709272 "PubMed citation" xref: CiteXplore:22763693 "PubMed citation" xref: CiteXplore:22770225 "PubMed citation" xref: CiteXplore:23016598 "PubMed citation" xref: CiteXplore:23028781 "PubMed citation" xref: CiteXplore:23043891 "PubMed citation" xref: CiteXplore:23047329 "PubMed citation" xref: CiteXplore:24559077 "PubMed citation" xref: CiteXplore:24635573 "PubMed citation" xref: CiteXplore:25504347 "PubMed citation" xref: CiteXplore:25561219 "PubMed citation" xref: CiteXplore:8620561 "PubMed citation" xref: DrugBank:DB02701 "DrugBank" xref: Gmelin:3336 "Gmelin Registry Number" xref: HMDB:HMDB01406 "HMDB" xref: KEGG COMPOUND:98-92-0 "CAS Registry Number" xref: KEGG COMPOUND:C00153 "KEGG COMPOUND" xref: KEGG DRUG:D00036 "KEGG DRUG" xref: KNApSAcK:C00000209 "KNApSAcK" xref: MetaCyc:NIACINAMIDE "MetaCyc" xref: NIST Chemistry WebBook:98-92-0 "CAS Registry Number" xref: Patent:US2904552 "Patent" xref: Patent:US2993051 "Patent" xref: PDBeChem:NCA "PDBeChem" xref: Reaxys:383619 "Reaxys Registry Number" xref: Wikipedia:Nicotinamide "Wikipedia" is_a: CHEBI:25529 ! pyridinecarboxamide is_a: CHEBI:26416 ! pyridine alkaloid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17158 name: methylglyoxal namespace: chebi_ontology alt_id: CHEBI:11643 alt_id: CHEBI:14599 alt_id: CHEBI:25303 alt_id: CHEBI:6875 def: "A 2-oxo aldehyde derived from propanal." [] synonym: "1,2-propanedione" RELATED [NIST Chemistry WebBook:] synonym: "2-Ketopropionaldehyde" RELATED [KEGG COMPOUND:] synonym: "2-Oxopropanal" RELATED [KEGG COMPOUND:] synonym: "2-oxopropanal" EXACT IUPAC_NAME [IUPAC:] synonym: "2-oxopropionaldehyde" RELATED [ChemIDplus:] synonym: "[H]C(=O)C(C)=O" RELATED SMILES [ChEBI:] synonym: "acetylformaldehyde" RELATED [ChemIDplus:] synonym: "acetylformyl" RELATED [NIST Chemistry WebBook:] synonym: "alpha-ketopropionaldehyde" RELATED [NIST Chemistry WebBook:] synonym: "C3H4O2" RELATED FORMULA [KEGG COMPOUND:] synonym: "CH3COCHO" RELATED [NIST Chemistry WebBook:] synonym: "InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3" RELATED InChI [ChEBI:] synonym: "InChIKey=AIJULSRZWUXGPQ-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "Methylglyoxal" EXACT [KEGG COMPOUND:] synonym: "methylglyoxal" EXACT [UniProt:] synonym: "Pyruvaldehyde" RELATED [KEGG COMPOUND:] synonym: "Pyruvic aldehyde" RELATED [KEGG COMPOUND:] xref: Beilstein:906750 "Beilstein Registry Number" xref: ChemIDplus:78-98-8 "CAS Registry Number" xref: CiteXplore:10373458 "PubMed citation" xref: CiteXplore:10723098 "PubMed citation" xref: CiteXplore:11504881 "PubMed citation" xref: CiteXplore:15520007 "PubMed citation" xref: CiteXplore:17103372 "PubMed citation" xref: CiteXplore:19202315 "PubMed citation" xref: CiteXplore:20096340 "PubMed citation" xref: CiteXplore:22983866 "PubMed citation" xref: CiteXplore:23543734 "PubMed citation" xref: CiteXplore:23845007 "PubMed citation" xref: CiteXplore:24040205 "PubMed citation" xref: CiteXplore:24168114 "PubMed citation" xref: CiteXplore:9506998 "PubMed citation" xref: KEGG COMPOUND:78-98-8 "CAS Registry Number" xref: KEGG COMPOUND:C00546 "KEGG COMPOUND" xref: KNApSAcK:C00007562 "KNApSAcK" xref: NIST Chemistry WebBook:78-98-8 "CAS Registry Number" xref: Reaxys:906750 "Reaxys Registry Number" xref: Wikipedia:Methylglyoxal "Wikipedia" is_a: CHEBI:26282 ! propanals is_a: CHEBI:27659 ! 2-oxo aldehyde property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:171741 name: cerulenin namespace: chebi_ontology alt_id: CHEBI:29552 def: "An epoxydodecadienamide isolated from several species, including Acremonium, Acrocylindrum and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function." [] synonym: "(2R,3S)-3-((4E,7E)-Nona-4,7-dienoyl)-oxirane-2-carboxylic acid amide" RELATED [ChEMBL:] synonym: "(2R,3S)-3-((4E,7E)-nona-4,7-dienoyl)oxirane-2-carboxamide" RELATED [ChEMBL:] synonym: "(2R,3S)-3-[(4E,7E)-nona-4,7-dienoyl]oxirane-2-carboxamide" EXACT IUPAC_NAME [IUPAC:] synonym: "[H][C@]1(O[C@]1([H])C(=O)CC\\C=C\\C\\C=C\\C)C(N)=O" RELATED SMILES [ChEBI:] synonym: "C12H17NO3" RELATED FORMULA [KEGG COMPOUND:] synonym: "Cerulenin" EXACT [KEGG COMPOUND:] synonym: "InChI=1S/C12H17NO3/c1-2-3-4-5-6-7-8-9(14)10-11(16-10)12(13)15/h2-3,5-6,10-11H,4,7-8H2,1H3,(H2,13,15)/b3-2+,6-5+/t10-,11-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=GVEZIHKRYBHEFX-NQQPLRFYSA-N" RELATED InChIKey [ChEBI:] xref: Beilstein:4807182 "Beilstein Registry Number" xref: ChemIDplus:17397-89-6 "CAS Registry Number" xref: DrugBank:DB01034 "DrugBank" xref: KEGG COMPOUND:17397-89-6 "CAS Registry Number" xref: KEGG COMPOUND:C12058 "KEGG COMPOUND" xref: KNApSAcK:C00018711 "KNApSAcK" is_a: CHEBI:29347 ! monocarboxylic acid amide is_a: CHEBI:32955 ! epoxide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17188 name: nucleoside monophosphate namespace: chebi_ontology alt_id: CHEBI:14676 alt_id: CHEBI:25607 alt_id: CHEBI:7439 alt_id: CHEBI:7653 alt_id: CHEBI:7654 synonym: "C5H10O7PR" RELATED FORMULA [ChEBI:] synonym: "NMP" RELATED [KEGG COMPOUND:] synonym: "Nucleoside monophosphate" EXACT [KEGG COMPOUND:] synonym: "nucleoside monophosphate" EXACT [ChEBI:] synonym: "nucleoside monophosphates" RELATED [ChEBI:] synonym: "Nucleoside phosphate" RELATED [KEGG COMPOUND:] synonym: "O[C@H]1[C@H]([*])O[C@H](COP(O)(O)=O)[C@H]1O" RELATED SMILES [ChEBI:] xref: KEGG COMPOUND:C01329 "KEGG COMPOUND" xref: KEGG COMPOUND:C03013 "KEGG COMPOUND" xref: KEGG COMPOUND:C05029 "KEGG COMPOUND" is_a: CHEBI:25608 ! nucleoside phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17191 name: L-isoleucine namespace: chebi_ontology alt_id: CHEBI:13127 alt_id: CHEBI:21344 alt_id: CHEBI:43290 alt_id: CHEBI:43342 alt_id: CHEBI:43366 alt_id: CHEBI:6255 def: "The L-enantiomer of isoleucine." [] synonym: "(2S,3S)-2-amino-3-methylpentanoic acid" RELATED [IUPAC:] synonym: "2-Amino-3-methylvaleric acid" RELATED [KEGG COMPOUND:] synonym: "alpha-amino-beta-methylvaleric acid" RELATED [NIST Chemistry WebBook:] synonym: "C6H13NO2" RELATED FORMULA [KEGG COMPOUND:] synonym: "CC[C@H](C)[C@H](N)C(O)=O" RELATED SMILES [ChEBI:] synonym: "I" RELATED [ChEBI:] synonym: "Ile" RELATED [ChEBI:] synonym: "InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=AGPKZVBTJJNPAG-WHFBIAKZSA-N" RELATED InChIKey [ChEBI:] synonym: "ISOLEUCINE" RELATED [PDBeChem:] synonym: "L-Isoleucine" EXACT [PDBeChem:] synonym: "L-Isoleucine" EXACT [KEGG COMPOUND:] synonym: "L-isoleucine" EXACT IUPAC_NAME [IUPAC:] xref: Beilstein:1721792 "Beilstein Registry Number" xref: ChemIDplus:73-32-5 "CAS Registry Number" xref: CiteXplore:14651987 "PubMed citation" xref: CiteXplore:16140883 "PubMed citation" xref: CiteXplore:17299083 "PubMed citation" xref: CiteXplore:17409434 "PubMed citation" xref: CiteXplore:22298573 "PubMed citation" xref: CiteXplore:24284437 "PubMed citation" xref: CiteXplore:24406630 "PubMed citation" xref: CiteXplore:24738868 "PubMed citation" xref: CiteXplore:24831709 "PubMed citation" xref: DrugBank:DB00167 "DrugBank" xref: ECMDB:ECMDB00172 "ECMDB" xref: Gmelin:486381 "Gmelin Registry Number" xref: HMDB:HMDB00172 "HMDB" xref: KEGG COMPOUND:73-32-5 "CAS Registry Number" xref: KEGG COMPOUND:C00407 "KEGG COMPOUND" xref: KEGG DRUG:D00065 "KEGG DRUG" xref: KNApSAcK:C00001374 "KNApSAcK" xref: MetaCyc:ILE "MetaCyc" xref: NIST Chemistry WebBook:73-32-5 "CAS Registry Number" xref: PDBeChem:ILE "PDBeChem" xref: Reaxys:1721792 "Reaxys Registry Number" xref: Wikipedia:Isoleucine "Wikipedia" xref: YMDB:YMDB00038 "YMDB" is_a: CHEBI:22658 ! aspartate family amino acid is_a: CHEBI:24898 ! isoleucine is_a: CHEBI:83813 ! proteinogenic amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17196 name: L-asparagine namespace: chebi_ontology alt_id: CHEBI:13083 alt_id: CHEBI:21242 alt_id: CHEBI:40902 alt_id: CHEBI:6191 def: "An optically active form of asparagine having L-configuration." [] synonym: "(2S)-2,4-diamino-4-oxobutanoic acid" RELATED [IUPAC:] synonym: "(2S)-2-amino-3-carbamoylpropanoic acid" RELATED [JCBN:] synonym: "(S)-2-amino-3-carbamoylpropanoic acid" RELATED [ChEBI:] synonym: "(S)-Asparagine" RELATED [DrugBank:] synonym: "2-Aminosuccinamic acid" RELATED [KEGG COMPOUND:] synonym: "alpha-aminosuccinamic acid" RELATED [ChemIDplus:] synonym: "Asn" RELATED [NIST Chemistry WebBook:] synonym: "ASPARAGINE" RELATED [PDBeChem:] synonym: "Aspartamic acid" RELATED [DrugBank:] synonym: "C4H8N2O3" RELATED FORMULA [KEGG COMPOUND:] synonym: "InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=DCXYFEDJOCDNAF-REOHCLBHSA-N" RELATED InChIKey [ChEBI:] synonym: "L-2-aminosuccinamic acid" RELATED [ChemIDplus:] synonym: "L-Asparagin" RELATED [ChEBI:] synonym: "L-Asparagine" EXACT [KEGG COMPOUND:] synonym: "L-asparagine" EXACT IUPAC_NAME [IUPAC:] synonym: "L-aspartic acid beta-amide" RELATED [ChEBI:] synonym: "N" RELATED [NIST Chemistry WebBook:] synonym: "N[C@@H](CC(N)=O)C(O)=O" RELATED SMILES [ChEBI:] xref: Beilstein:1723527 "Beilstein Registry Number" xref: ChemIDplus:70-47-3 "CAS Registry Number" xref: CiteXplore:12142634 "PubMed citation" xref: CiteXplore:15907185 "PubMed citation" xref: CiteXplore:16190636 "PubMed citation" xref: CiteXplore:16368161 "PubMed citation" xref: CiteXplore:16668324 "PubMed citation" xref: CiteXplore:17497286 "PubMed citation" xref: CiteXplore:21800258 "PubMed citation" xref: CiteXplore:21854356 "PubMed citation" xref: CiteXplore:22513289 "PubMed citation" xref: DrugBank:DB00174 "DrugBank" xref: ECMDB:ECMDB00168 "ECMDB" xref: Gmelin:3334 "Gmelin Registry Number" xref: HMDB:HMDB00168 "HMDB" xref: KEGG COMPOUND:70-47-3 "CAS Registry Number" xref: KEGG COMPOUND:C00152 "KEGG COMPOUND" xref: KNApSAcK:C00001341 "KNApSAcK" xref: MetaCyc:ASN "MetaCyc" xref: NIST Chemistry WebBook:70-47-3 "CAS Registry Number" xref: PDBeChem:ASN "PDBeChem" xref: Reaxys:1723527 "Reaxys Registry Number" xref: Wikipedia:Asparagine "Wikipedia" xref: YMDB:YMDB00226 "YMDB" is_a: CHEBI:22653 ! asparagine is_a: CHEBI:22658 ! aspartate family amino acid is_a: CHEBI:83813 ! proteinogenic amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17203 name: L-proline namespace: chebi_ontology alt_id: CHEBI:13154 alt_id: CHEBI:184637 alt_id: CHEBI:21373 alt_id: CHEBI:42067 alt_id: CHEBI:45040 alt_id: CHEBI:45100 alt_id: CHEBI:45159 alt_id: CHEBI:6286 def: "Pyrrolidine in which the pro-S hydrogen at position 2 is substituted by a carboxylic acid group. L-Proline is the only one of the twenty DNA-encoded amino acids which has a secondary amino group alpha to the carboxyl group. It is an essential component of collagen and is important for proper functioning of joints and tendons. It also helps maintain and strengthen heart muscles." [] synonym: "(-)-(S)-proline" RELATED [NIST Chemistry WebBook:] synonym: "(-)-2-pyrrolidinecarboxylic acid" RELATED [ChemIDplus:] synonym: "(-)-proline" RELATED [ChemIDplus:] synonym: "(2S)-pyrrolidine-2-carboxylic acid" RELATED [IUPAC:] synonym: "(S)-2-carboxypyrrolidine" RELATED [DrugBank:] synonym: "(S)-2-pyrrolidinecarboxylic acid" RELATED [ChemIDplus:] synonym: "(S)-pyrrolidine-2-carboxylic acid" RELATED [ChEBI:] synonym: "2-Pyrrolidinecarboxylic acid" RELATED [KEGG COMPOUND:] synonym: "C5H9NO2" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=ONIBWKKTOPOVIA-BYPYZUCNSA-N" RELATED InChIKey [ChEBI:] synonym: "L-(-)-proline" RELATED [NIST Chemistry WebBook:] synonym: "L-alpha-pyrrolidinecarboxylic acid" RELATED [ChemIDplus:] synonym: "L-Prolin" RELATED [ChEBI:] synonym: "L-Proline" EXACT [KEGG COMPOUND:] synonym: "L-proline" EXACT IUPAC_NAME [IUPAC:] synonym: "L-pyrrolidine-2-carboxylic acid" RELATED [ChemIDplus:] synonym: "OC(=O)[C@@H]1CCCN1" RELATED SMILES [ChEBI:] synonym: "P" RELATED [ChEBI:] synonym: "prolina" RELATED [ChemIDplus:] synonym: "PROLINE" RELATED [PDBeChem:] synonym: "proline" RELATED INN [ChemIDplus:] synonym: "prolinum" RELATED [ChemIDplus:] xref: Beilstein:80810 "Beilstein Registry Number" xref: ChemIDplus:147-85-3 "CAS Registry Number" xref: CiteXplore:11076505 "PubMed citation" xref: CiteXplore:12770004 "PubMed citation" xref: CiteXplore:14975886 "PubMed citation" xref: CiteXplore:15576824 "PubMed citation" xref: CiteXplore:15838615 "PubMed citation" xref: CiteXplore:15894682 "PubMed citation" xref: CiteXplore:15973048 "PubMed citation" xref: CiteXplore:16033917 "PubMed citation" xref: CiteXplore:16190672 "PubMed citation" xref: CiteXplore:16501220 "PubMed citation" xref: CiteXplore:16656443 "PubMed citation" xref: CiteXplore:16657874 "PubMed citation" xref: CiteXplore:16668324 "PubMed citation" xref: CiteXplore:17127472 "PubMed citation" xref: CiteXplore:17608428 "PubMed citation" xref: CiteXplore:18551589 "PubMed citation" xref: CiteXplore:18802692 "PubMed citation" xref: CiteXplore:18973300 "PubMed citation" xref: CiteXplore:19215998 "PubMed citation" xref: CiteXplore:19580280 "PubMed citation" xref: CiteXplore:19656302 "PubMed citation" xref: CiteXplore:19688381 "PubMed citation" xref: CiteXplore:19811425 "PubMed citation" xref: CiteXplore:22139509 "PubMed citation" xref: CiteXplore:22201772 "PubMed citation" xref: CiteXplore:22451406 "PubMed citation" xref: CiteXplore:22475019 "PubMed citation" xref: CiteXplore:22482728 "PubMed citation" xref: CiteXplore:22491679 "PubMed citation" xref: CiteXplore:22770225 "PubMed citation" xref: DrugBank:DB00172 "DrugBank" xref: Gmelin:50152 "Gmelin Registry Number" xref: HMDB:HMDB00162 "HMDB" xref: KEGG COMPOUND:147-85-3 "CAS Registry Number" xref: KEGG COMPOUND:C00148 "KEGG COMPOUND" xref: KEGG DRUG:D00035 "KEGG DRUG" xref: KNApSAcK:C00001388 "KNApSAcK" xref: MetaCyc:PRO "MetaCyc" xref: NIST Chemistry WebBook:147-85-3 "CAS Registry Number" xref: PDBeChem:PRO "PDBeChem" xref: Reaxys:80810 "Reaxys Registry Number" xref: Wikipedia:L-proline "Wikipedia" is_a: CHEBI:24318 ! glutamine family amino acid is_a: CHEBI:26271 ! proline is_a: CHEBI:83813 ! proteinogenic amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17230 name: homocysteine namespace: chebi_ontology alt_id: CHEBI:14408 alt_id: CHEBI:5751 def: "A sulfur-containing amino acid consisting of a glycine core with a 2-mercaptoethyl side-chain." [] synonym: "2-Amino-4-mercaptobutyric acid" RELATED [KEGG COMPOUND:] synonym: "2-amino-4-sulfanylbutanoic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "C4H9NO2S" RELATED FORMULA [KEGG COMPOUND:] synonym: "Hcy" RELATED [IUPAC:] synonym: "Homocysteine" EXACT [KEGG COMPOUND:] synonym: "homocysteine" EXACT IUPAC_NAME [IUPAC:] synonym: "InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)" RELATED InChI [ChEBI:] synonym: "InChIKey=FFFHZYDWPBMWHY-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "NC(CCS)C(O)=O" RELATED SMILES [ChEBI:] xref: CiteXplore:11133260 "PubMed citation" xref: CiteXplore:16596805 "PubMed citation" xref: CiteXplore:18370634 "PubMed citation" xref: HMDB:HMDB00742 "HMDB" xref: KEGG COMPOUND:C05330 "KEGG COMPOUND" xref: Wikipedia:Homocysteine "Wikipedia" is_a: CHEBI:24610 ! homocysteines is_a: CHEBI:26834 ! sulfur-containing amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17234 name: glucose namespace: chebi_ontology alt_id: CHEBI:14313 alt_id: CHEBI:24277 alt_id: CHEBI:33929 alt_id: CHEBI:5418 def: "An aldohexose used as a source of energy and metabolic intermediate." [] synonym: "C6H12O6" RELATED FORMULA [KEGG COMPOUND:] synonym: "Glc" RELATED [JCBN:] synonym: "gluco-hexose" EXACT IUPAC_NAME [IUPAC:] synonym: "Glucose" EXACT [KEGG COMPOUND:] synonym: "glucose" EXACT [UniProt:] synonym: "glucose" EXACT IUPAC_NAME [IUPAC:] synonym: "Glukose" RELATED [ChEBI:] xref: KEGG COMPOUND:50-99-7 "CAS Registry Number" xref: KEGG COMPOUND:C00293 "KEGG COMPOUND" xref: Wikipedia:Glucose "Wikipedia" is_a: CHEBI:33917 ! aldohexose property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17295 name: L-phenylalanine namespace: chebi_ontology alt_id: CHEBI:13151 alt_id: CHEBI:21370 alt_id: CHEBI:44851 alt_id: CHEBI:44885 alt_id: CHEBI:45079 alt_id: CHEBI:6282 def: "The L-enantiomer of phenylalanine." [] synonym: "(2S)-2-amino-3-phenylpropanoic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "(S)-2-Amino-3-phenylpropionic acid" RELATED [HMDB:] synonym: "(S)-alpha-Amino-beta-phenylpropionic acid" RELATED [KEGG COMPOUND:] synonym: "3-phenyl-L-alanine" RELATED [NIST Chemistry WebBook:] synonym: "beta-phenyl-L-alanine" RELATED [NIST Chemistry WebBook:] synonym: "C9H11NO2" RELATED FORMULA [KEGG COMPOUND:] synonym: "F" RELATED [ChEBI:] synonym: "InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=COLNVLDHVKWLRT-QMMMGPOBSA-N" RELATED InChIKey [ChEBI:] synonym: "L-Phenylalanine" EXACT [KEGG COMPOUND:] synonym: "L-phenylalanine" EXACT IUPAC_NAME [IUPAC:] synonym: "N[C@@H](Cc1ccccc1)C(O)=O" RELATED SMILES [ChEBI:] synonym: "Phe" RELATED [ChEBI:] synonym: "PHENYLALANINE" RELATED [PDBeChem:] xref: Beilstein:1910408 "Beilstein Registry Number" xref: ChemIDplus:63-91-2 "CAS Registry Number" xref: CiteXplore:16893175 "PubMed citation" xref: CiteXplore:17784858 "PubMed citation" xref: CiteXplore:21203787 "PubMed citation" xref: CiteXplore:21956539 "PubMed citation" xref: CiteXplore:22081386 "PubMed citation" xref: CiteXplore:22112574 "PubMed citation" xref: CiteXplore:22143120 "PubMed citation" xref: CiteXplore:22209218 "PubMed citation" xref: CiteXplore:22494897 "PubMed citation" xref: CiteXplore:23836015 "PubMed citation" xref: CiteXplore:24464217 "PubMed citation" xref: CiteXplore:24733517 "PubMed citation" xref: CiteXplore:24966042 "PubMed citation" xref: DrugBank:DB00120 "DrugBank" xref: ECMDB:ECMDB00159 "ECMDB" xref: Gmelin:50837 "Gmelin Registry Number" xref: HMDB:HMDB00159 "HMDB" xref: KEGG COMPOUND:63-91-2 "CAS Registry Number" xref: KEGG COMPOUND:C00079 "KEGG COMPOUND" xref: KEGG DRUG:D00021 "KEGG DRUG" xref: KNApSAcK:C00001386 "KNApSAcK" xref: MetaCyc:PHE "MetaCyc" xref: NIST Chemistry WebBook:63-91-2 "CAS Registry Number" xref: PDBeChem:PHE "PDBeChem" xref: Reaxys:1910408 "Reaxys Registry Number" xref: Wikipedia:Phenylalanine "Wikipedia" xref: YMDB:YMDB00304 "YMDB" is_a: CHEBI:28044 ! phenylalanine is_a: CHEBI:73690 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid is_a: CHEBI:83813 ! proteinogenic amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17306 name: maltose namespace: chebi_ontology alt_id: CHEBI:14568 alt_id: CHEBI:25144 alt_id: CHEBI:6668 def: "A glycosylglucose consisting of two D-glucopyranose units connected by an alpha-(1->4)-linkage." [] synonym: "1-alpha-D-Glucopyranosyl-4-alpha-D-glucopyranose" RELATED [KEGG COMPOUND:] synonym: "4-(alpha-D-glucopyranosido)-alpha-glucopyranose" RELATED [NIST Chemistry WebBook:] synonym: "4-(alpha-D-glucosido)-D-glucose" RELATED [NIST Chemistry WebBook:] synonym: "4-O-alpha-D-glucopyranosyl-D-glucopyranose" RELATED [IUPAC:] synonym: "4-O-alpha-D-glucopyranosyl-D-glucose" RELATED [NIST Chemistry WebBook:] synonym: "alpha-D-Glcp-(1->4)-D-Glcp" RELATED [IUPAC:] synonym: "alpha-D-Glucopyranosyl-(1->4)-D-glucopyranose" RELATED [KEGG COMPOUND:] synonym: "alpha-D-glucopyranosyl-(1->4)-D-glucopyranose" EXACT IUPAC_NAME [IUPAC:] synonym: "alpha-D-glucopyranosyl-(1->4)-D-glucose" EXACT IUPAC_NAME [IUPAC:] synonym: "alpha-malt sugar" RELATED [NIST Chemistry WebBook:] synonym: "C12H22O11" RELATED FORMULA [KEGG COMPOUND:] synonym: "Cextromaltose" RELATED [NIST Chemistry WebBook:] synonym: "D-(+)-maltose" RELATED [ChemIDplus:] synonym: "D-maltose" RELATED [NIST Chemistry WebBook:] synonym: "InChI=1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5-,6+,7-,8-,9-,10-,11?,12-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=GUBGYTABKSRVRQ-PICCSMPSSA-N" RELATED InChIKey [ChEBI:] synonym: "Malt sugar" RELATED [KEGG COMPOUND:] synonym: "maltobiose" RELATED [NIST Chemistry WebBook:] synonym: "Maltose" EXACT [KEGG COMPOUND:] synonym: "maltose" EXACT [UniProt:] synonym: "Malzzucker" RELATED [ChEBI:] synonym: "OC[C@H]1O[C@H](O[C@@H]2[C@@H](CO)OC(O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O" RELATED SMILES [ChEBI:] xref: Beilstein:1292747 "Beilstein Registry Number" xref: ChemIDplus:69-79-4 "CAS Registry Number" xref: CiteXplore:16332759 "PubMed citation" xref: CiteXplore:17723085 "PubMed citation" xref: CiteXplore:22094343 "PubMed citation" xref: CiteXplore:22185612 "PubMed citation" xref: CiteXplore:22246222 "PubMed citation" xref: CiteXplore:22252265 "PubMed citation" xref: CiteXplore:22411612 "PubMed citation" xref: CiteXplore:22424089 "PubMed citation" xref: CiteXplore:22451670 "PubMed citation" xref: CiteXplore:22469630 "PubMed citation" xref: CiteXplore:22529943 "PubMed citation" xref: CiteXplore:22573161 "PubMed citation" xref: CiteXplore:22669197 "PubMed citation" xref: DrugBank:DB03323 "DrugBank" xref: KEGG COMPOUND:69-79-4 "CAS Registry Number" xref: KEGG COMPOUND:C00208 "KEGG COMPOUND" xref: KEGG DRUG:D00044 "KEGG DRUG" xref: KEGG GLYCAN:G00275 "KEGG GLYCAN" xref: KNApSAcK:C00001140 "KNApSAcK" xref: NIST Chemistry WebBook:69-79-4 "CAS Registry Number" xref: Reaxys:1292747 "Reaxys Registry Number" xref: Wikipedia:Maltose "Wikipedia" is_a: CHEBI:17593 ! maltooligosaccharide is_a: CHEBI:24405 ! glycosylglucose property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17310 name: pyridoxal namespace: chebi_ontology alt_id: CHEBI:14976 alt_id: CHEBI:26423 alt_id: CHEBI:45112 alt_id: CHEBI:8667 def: "A pyridinecarbaldehyde that is pyridine-4-carbaldehyde bearing methyl, hydroxy and hydroxymethyl substituents at positions 2, 3 and 5 respectively." [] synonym: "3-HYDROXY-5-(HYDROXYMETHYL)-2-METHYLISONICOTINALDEHYDE" RELATED [PDBeChem:] synonym: "3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carbaldehyde" EXACT IUPAC_NAME [IUPAC:] synonym: "[H]C(=O)c1c(CO)cnc(C)c1O" RELATED SMILES [ChEBI:] synonym: "C8H9NO3" RELATED FORMULA [KEGG COMPOUND:] synonym: "InChI=1S/C8H9NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,4,10,12H,3H2,1H3" RELATED InChI [ChEBI:] synonym: "InChIKey=RADKZDMFGJYCBB-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "Pyridoxal" EXACT [KEGG COMPOUND:] synonym: "pyridoxal" EXACT [UniProt:] synonym: "pyridoxaldehyde" RELATED [ChemIDplus:] xref: Beilstein:383768 "Beilstein Registry Number" xref: ChemIDplus:66-72-8 "CAS Registry Number" xref: CiteXplore:17765195 "PubMed citation" xref: CiteXplore:20381632 "PubMed citation" xref: CiteXplore:22770225 "PubMed citation" xref: CiteXplore:23801094 "PubMed citation" xref: CiteXplore:24365359 "PubMed citation" xref: DrugBank:DB00147 "DrugBank" xref: Gmelin:218674 "Gmelin Registry Number" xref: HMDB:HMDB01545 "HMDB" xref: KEGG COMPOUND:66-72-8 "CAS Registry Number" xref: KEGG COMPOUND:C00250 "KEGG COMPOUND" xref: KNApSAcK:C00007509 "KNApSAcK" xref: MetaCyc:PYRIDOXAL "MetaCyc" xref: PDBeChem:PXL "PDBeChem" xref: Reaxys:383768 "Reaxys Registry Number" xref: Wikipedia:Pyridoxal "Wikipedia" is_a: CHEBI:25340 ! methylpyridines is_a: CHEBI:27306 ! vitamin B6 is_a: CHEBI:38182 ! monohydroxypyridine is_a: CHEBI:38187 ! pyridinecarbaldehyde is_a: CHEBI:38196 ! hydroxymethylpyridine property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17326 name: nucleoside triphosphate namespace: chebi_ontology alt_id: CHEBI:13411 alt_id: CHEBI:14677 alt_id: CHEBI:25610 alt_id: CHEBI:7442 alt_id: CHEBI:7655 synonym: "C5H12O13P3R" RELATED FORMULA [ChEBI:] synonym: "C[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O" RELATED SMILES [ChEBI:] synonym: "NTP" RELATED [KEGG COMPOUND:] synonym: "Nucleoside triphosphate" EXACT [KEGG COMPOUND:] synonym: "nucleoside triphosphates" RELATED [ChEBI:] xref: KEGG COMPOUND:C00201 "KEGG COMPOUND" is_a: CHEBI:25608 ! nucleoside phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17359 name: sulfite namespace: chebi_ontology alt_id: CHEBI:15139 alt_id: CHEBI:45548 def: "Sulfite is an inorganic anion, which is the conjugate base of hydrogen sulfite." [] synonym: "[O-]S([O-])=O" RELATED SMILES [ChEBI:] synonym: "[SO3](2-)" RELATED [IUPAC:] synonym: "InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-2" RELATED InChI [ChEBI:] synonym: "InChIKey=LSNNMFCWUKXFEE-UHFFFAOYSA-L" RELATED InChIKey [ChEBI:] synonym: "O3S" RELATED FORMULA [ChEBI:] synonym: "SO3(2-)" RELATED [IUPAC:] synonym: "sulfite" EXACT [UniProt:] synonym: "sulfite" EXACT IUPAC_NAME [IUPAC:] synonym: "sulfite" EXACT [PDBeChem:] synonym: "SULFITE ION" RELATED [PDBeChem:] synonym: "sulphite" RELATED [ChEBI:] synonym: "trioxidosulfate(2-)" EXACT IUPAC_NAME [IUPAC:] synonym: "trioxosulfate(2-)" EXACT IUPAC_NAME [IUPAC:] synonym: "trioxosulfate(IV)" EXACT IUPAC_NAME [IUPAC:] xref: ChemIDplus:14265-45-3 "CAS Registry Number" xref: Gmelin:1449 "Gmelin Registry Number" xref: PDBeChem:SO3 "PDBeChem" is_a: CHEBI:33482 ! sulfur oxoanion is_a: CHEBI:48154 ! sulfur oxide is_a: CHEBI:79388 ! divalent inorganic anion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17407 name: 2-trans,6-trans-farnesyl diphosphate namespace: chebi_ontology alt_id: CHEBI:10700 alt_id: CHEBI:11488 alt_id: CHEBI:11491 alt_id: CHEBI:12854 alt_id: CHEBI:12874 alt_id: CHEBI:19789 alt_id: CHEBI:42496 def: "The trans,trans-stereoisomer of farnesyl diphosphate." [] synonym: "(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl trihydrogen diphosphate" EXACT IUPAC_NAME [IUPAC:] synonym: "(2E,6E)-farnesol diphosphate" RELATED [ChEBI:] synonym: "(2E,6E)-Farnesyl diphosphate" RELATED [KEGG COMPOUND:] synonym: "(2E,6E)-farnesyl diphosphate" RELATED [ChemIDplus:] synonym: "(2E,6E)-farnesyl pyrophosphate" RELATED [ChemIDplus:] synonym: "(all-E)-farnesyl diphosphate" RELATED [ChemIDplus:] synonym: "(E,E)-farnesyl pyrophosphate" RELATED [ChemIDplus:] synonym: "2-trans,6-trans-Farnesyl diphosphate" EXACT [KEGG COMPOUND:] synonym: "2-trans,6-trans-farnesyl diphosphate" EXACT [ChEBI:] synonym: "2-trans,6-trans-farnesyl pyrophosphate" RELATED [ChemIDplus:] synonym: "all-trans-farnesyl pyrophosphate" RELATED [ChemIDplus:] synonym: "C15H28O7P2" RELATED FORMULA [KEGG COMPOUND:] synonym: "CC(C)=CCC\\C(C)=C\\CC\\C(C)=C\\COP(O)(=O)OP(O)(O)=O" RELATED SMILES [ChEBI:] synonym: "FARNESYL DIPHOSPHATE" RELATED [PDBeChem:] synonym: "Farnesyl diphosphate" RELATED [KEGG COMPOUND:] synonym: "Farnesyl pyrophosphate" RELATED [KEGG COMPOUND:] synonym: "InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/b14-9+,15-11+" RELATED InChI [ChEBI:] synonym: "InChIKey=VWFJDQUYCIWHTN-YFVJMOTDSA-N" RELATED InChIKey [ChEBI:] synonym: "trans,trans-Farnesyl diphosphate" RELATED [KEGG COMPOUND:] synonym: "trans,trans-farnesyl diphosphate" RELATED [ChemIDplus:] synonym: "trans,trans-farnesyl diphosphate" RELATED [ChEBI:] synonym: "trans-trans-farnesyl diphosphate" RELATED [ChEBI:] xref: Beilstein:2482197 "Beilstein Registry Number" xref: ChemIDplus:372-97-4 "CAS Registry Number" xref: CiteXplore:7753173 "PubMed citation" xref: KEGG COMPOUND:13058-04-3 "CAS Registry Number" xref: KEGG COMPOUND:372-97-4 "CAS Registry Number" xref: KEGG COMPOUND:C00448 "KEGG COMPOUND" xref: KNApSAcK:C00000907 "KNApSAcK" xref: KNApSAcK:C00007268 "KNApSAcK" xref: LIPID MAPS:LMPR0103010002 "LIPID MAPS instance" xref: PDBeChem:FPP "PDBeChem" is_a: CHEBI:50277 ! farnesyl diphosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17478 name: aldehyde namespace: chebi_ontology alt_id: CHEBI:13432 alt_id: CHEBI:13753 alt_id: CHEBI:13805 alt_id: CHEBI:13806 alt_id: CHEBI:22291 alt_id: CHEBI:2554 alt_id: CHEBI:8750 def: "A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group." [] synonym: "[H]C([*])=O" RELATED SMILES [ChEBI:] synonym: "aldehido" RELATED [ChEBI:] synonym: "aldehidos" RELATED [ChEBI:] synonym: "Aldehyd" RELATED [ChEBI:] synonym: "Aldehyde" EXACT [KEGG COMPOUND:] synonym: "aldehyde" EXACT IUPAC_NAME [IUPAC:] synonym: "aldehyde" EXACT [ChEBI:] synonym: "aldehydes" EXACT IUPAC_NAME [IUPAC:] synonym: "aldehydes" RELATED [ChEBI:] synonym: "aldehydum" RELATED [ChEBI:] synonym: "an aldehyde" RELATED [UniProt:] synonym: "CHOR" RELATED FORMULA [ChEBI:] synonym: "RC(=O)H" RELATED [IUPAC:] synonym: "RCHO" RELATED [KEGG COMPOUND:] xref: KEGG COMPOUND:C00071 "KEGG COMPOUND" is_a: CHEBI:36586 ! carbonyl compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17489 name: 3',5'-cyclic AMP namespace: chebi_ontology alt_id: CHEBI:11673 alt_id: CHEBI:1325 alt_id: CHEBI:19827 alt_id: CHEBI:41588 def: "A 3',5'-cyclic purine nucleotide having having adenine as the nucleobase." [] synonym: "3',5'-Cyclic AMP" EXACT [KEGG COMPOUND:] synonym: "adenosine 3',5'-(hydrogen phosphate)" EXACT IUPAC_NAME [IUPAC:] synonym: "adenosine 3',5'-cyclic monophosphate" RELATED [NIST Chemistry WebBook:] synonym: "Adenosine 3',5'-cyclic phosphate" RELATED [KEGG COMPOUND:] synonym: "Adenosine 3',5'-phosphate" RELATED [KEGG COMPOUND:] synonym: "ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE" RELATED [PDBeChem:] synonym: "C10H12N5O6P" RELATED FORMULA [KEGG COMPOUND:] synonym: "cAMP" RELATED [KEGG COMPOUND:] synonym: "Cyclic adenylic acid" RELATED [KEGG COMPOUND:] synonym: "Cyclic AMP" RELATED [KEGG COMPOUND:] synonym: "InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=IVOMOUWHDPKRLL-KQYNXXCUSA-N" RELATED InChIKey [ChEBI:] synonym: "Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]2COP(O)(=O)O[C@H]2[C@H]1O" RELATED SMILES [ChEBI:] xref: Beilstein:52645 "Beilstein Registry Number" xref: ChemIDplus:60-92-4 "CAS Registry Number" xref: CiteXplore:16295522 "PubMed citation" xref: CiteXplore:18372334 "PubMed citation" xref: CiteXplore:22770225 "PubMed citation" xref: DrugBank:DB02527 "DrugBank" xref: HMDB:HMDB00058 "HMDB" xref: KEGG COMPOUND:60-92-4 "CAS Registry Number" xref: KEGG COMPOUND:C00575 "KEGG COMPOUND" xref: KNApSAcK:C00001497 "KNApSAcK" xref: MetaCyc:CAMP "MetaCyc" xref: NIST Chemistry WebBook:60-92-4 "CAS Registry Number" xref: PDBeChem:CMP "PDBeChem" xref: Reaxys:52645 "Reaxys Registry Number" xref: Wikipedia:Cyclic_AMP "Wikipedia" is_a: CHEBI:19834 ! 3',5'-cyclic purine nucleotide is_a: CHEBI:61296 ! adenyl ribonucleotide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17522 name: alditol namespace: chebi_ontology alt_id: CHEBI:13754 alt_id: CHEBI:22298 alt_id: CHEBI:2556 def: "A carbohydrate that is an acyclic polyol having the general formula HOCH2[CH(OH)]nCH2OH (formally derivable from an aldose by reduction of the carbonyl group)." [] synonym: "(CH2O)nC2H6O2" RELATED FORMULA [ChEBI:] synonym: "Alditol" EXACT [KEGG COMPOUND:] synonym: "alditols" RELATED [ChEBI:] synonym: "Glycitol" RELATED [KEGG COMPOUND:] synonym: "Sugar alcohol" RELATED [KEGG COMPOUND:] xref: KEGG COMPOUND:C00717 "KEGG COMPOUND" xref: Wikipedia:Glycerin "Wikipedia" is_a: CHEBI:16646 ! carbohydrate is_a: CHEBI:26191 ! polyol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17561 name: L-cysteine namespace: chebi_ontology alt_id: CHEBI:13095 alt_id: CHEBI:21261 alt_id: CHEBI:41227 alt_id: CHEBI:41700 alt_id: CHEBI:41768 alt_id: CHEBI:41781 alt_id: CHEBI:41811 alt_id: CHEBI:6207 def: "An optically active form of cysteine having L-configuration." [] synonym: "(2R)-2-amino-3-mercaptopropanoic acid" RELATED [JCBN:] synonym: "(2R)-2-amino-3-sulfanylpropanoic acid" RELATED [IUPAC:] synonym: "(R)-2-amino-3-mercaptopropanoic acid" RELATED [NIST Chemistry WebBook:] synonym: "C" RELATED [ChEBI:] synonym: "C3H7NO2S" RELATED FORMULA [ChEBI:] synonym: "Cys" RELATED [ChEBI:] synonym: "CYSTEINE" RELATED [PDBeChem:] synonym: "E920" RELATED [ChEBI:] synonym: "FREE CYSTEINE" RELATED [PDBeChem:] synonym: "InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=XUJNEKJLAYXESH-REOHCLBHSA-N" RELATED InChIKey [ChEBI:] synonym: "L-2-Amino-3-mercaptopropionic acid" RELATED [KEGG COMPOUND:] synonym: "L-Cystein" RELATED [ChEBI:] synonym: "L-Cysteine" EXACT [KEGG COMPOUND:] synonym: "L-cysteine" EXACT IUPAC_NAME [IUPAC:] synonym: "L-Zystein" RELATED [ChEBI:] synonym: "N[C@@H](CS)C(O)=O" RELATED SMILES [ChEBI:] xref: Beilstein:1721408 "Beilstein Registry Number" xref: ChemIDplus:52-90-4 "CAS Registry Number" xref: CiteXplore:11732994 "PubMed citation" xref: CiteXplore:13761469 "PubMed citation" xref: CiteXplore:22735334 "PubMed citation" xref: DrugBank:DB00151 "DrugBank" xref: ECMDB:ECMDB00574 "ECMDB" xref: Gmelin:49991 "Gmelin Registry Number" xref: HMDB:HMDB00574 "HMDB" xref: KEGG COMPOUND:52-90-4 "CAS Registry Number" xref: KEGG COMPOUND:C00097 "KEGG COMPOUND" xref: KEGG DRUG:D00026 "KEGG DRUG" xref: KNApSAcK:C00001351 "KNApSAcK" xref: MetaCyc:CYS "MetaCyc" xref: NIST Chemistry WebBook:52-90-4 "CAS Registry Number" xref: PDBeChem:CYS "PDBeChem" xref: Reaxys:1721408 "Reaxys Registry Number" xref: Wikipedia:Cysteine "Wikipedia" xref: YMDB:YMDB00046 "YMDB" is_a: CHEBI:15356 ! cysteine is_a: CHEBI:26650 ! serine family amino acid is_a: CHEBI:83813 ! proteinogenic amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17568 name: uracil namespace: chebi_ontology alt_id: CHEBI:15288 alt_id: CHEBI:27210 alt_id: CHEBI:46375 alt_id: CHEBI:9882 def: "A common and naturally occurring pyrimidine nucleobase in which the pyrimidine ring is substituted with two oxo groups at positions 2 and 4. Found in RNA, it base pairs with adenine and replaces thymine during DNA transcription." [] synonym: "2,4(1H,3H)-pyrimidinedione" RELATED [NIST Chemistry WebBook:] synonym: "2,4-Dioxopyrimidine" RELATED [HMDB:] synonym: "2,4-Pyrimidinedione" RELATED [HMDB:] synonym: "C4H4N2O2" RELATED FORMULA [KEGG COMPOUND:] synonym: "InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)" RELATED InChI [ChEBI:] synonym: "InChIKey=ISAKRJDGNUQOIC-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "O=c1cc[nH]c(=O)[nH]1" RELATED SMILES [ChEBI:] synonym: "pyrimidine-2,4(1H,3H)-dione" EXACT IUPAC_NAME [IUPAC:] synonym: "U" RELATED [ChEBI:] synonym: "Ura" RELATED [CBN:] synonym: "URACIL" EXACT [PDBeChem:] synonym: "Uracil" EXACT [KEGG COMPOUND:] synonym: "uracil" EXACT [UniProt:] synonym: "Urazil" RELATED [ChEBI:] xref: Beilstein:606623 "Beilstein Registry Number" xref: ChemIDplus:66-22-8 "CAS Registry Number" xref: CiteXplore:11279060 "PubMed citation" xref: CiteXplore:12855717 "PubMed citation" xref: CiteXplore:15274295 "PubMed citation" xref: CiteXplore:16834123 "PubMed citation" xref: CiteXplore:17439666 "PubMed citation" xref: CiteXplore:18533995 "PubMed citation" xref: CiteXplore:18815805 "PubMed citation" xref: CiteXplore:19175333 "PubMed citation" xref: CiteXplore:21848266 "PubMed citation" xref: CiteXplore:22020693 "PubMed citation" xref: CiteXplore:22074393 "PubMed citation" xref: CiteXplore:22120518 "PubMed citation" xref: CiteXplore:22171528 "PubMed citation" xref: CiteXplore:22237209 "PubMed citation" xref: CiteXplore:22299724 "PubMed citation" xref: CiteXplore:22356544 "PubMed citation" xref: CiteXplore:22447672 "PubMed citation" xref: CiteXplore:22483865 "PubMed citation" xref: CiteXplore:22567906 "PubMed citation" xref: CiteXplore:22685418 "PubMed citation" xref: CiteXplore:3654008 "PubMed citation" xref: DrugBank:DB03419 "DrugBank" xref: Gmelin:2896 "Gmelin Registry Number" xref: HMDB:HMDB00300 "HMDB" xref: KEGG COMPOUND:66-22-8 "CAS Registry Number" xref: KEGG COMPOUND:C00106 "KEGG COMPOUND" xref: KEGG DRUG:D00027 "KEGG DRUG" xref: KNApSAcK:C00001513 "KNApSAcK" xref: MetaCyc:URACIL "MetaCyc" xref: NIST Chemistry WebBook:66-22-8 "CAS Registry Number" xref: PDBeChem:URA "PDBeChem" xref: Reaxys:606623 "Reaxys Registry Number" xref: Wikipedia:Uracil "Wikipedia" is_a: CHEBI:26432 ! pyrimidine nucleobase is_a: CHEBI:38337 ! pyrimidone property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17593 name: maltooligosaccharide namespace: chebi_ontology alt_id: CHEBI:11169 alt_id: CHEBI:18926 alt_id: CHEBI:543 alt_id: CHEBI:64478 def: "A glucooligosaccharide derived from glucose monomers linked via alpha-D-1,4 bonds as in maltose. The term is commonly applied to the series of linear oligosaccharides composed of two, three, four, five and six such units of glucose." [] synonym: "(1->4)-alpha-D-glucooligosaccharides" RELATED [ChEBI:] synonym: "1,4-alpha-D-Glucooligosaccharide" RELATED [KEGG COMPOUND:] synonym: "1,4-alpha-D-glucooligosaccharide" RELATED [UniProt:] synonym: "1,4-alpha-D-glucooligosaccharide" RELATED [ChEBI:] synonym: "maltooligosaccharides" RELATED [ChEBI:] xref: KEGG COMPOUND:C04099 "KEGG COMPOUND" is_a: CHEBI:24268 ! glucooligosaccharide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17608 name: D-aldohexose namespace: chebi_ontology alt_id: CHEBI:12990 alt_id: CHEBI:21038 def: "Any D-aldose having a chain of six carbon atoms in the molecule." [] synonym: "C6H12O6" RELATED FORMULA [ChEBI:] synonym: "D-aldohexose" EXACT [UniProt:] synonym: "D-aldohexoses" RELATED [ChEBI:] is_a: CHEBI:33917 ! aldohexose is_a: CHEBI:4194 ! D-hexose property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17634 name: D-glucose namespace: chebi_ontology alt_id: CHEBI:12965 alt_id: CHEBI:20999 def: "A glucose with D-configuration." [] synonym: "C6H12O6" RELATED FORMULA [ChEBI:] synonym: "D(+)-glucose" RELATED [ChemIDplus:] synonym: "D-(+)-glucose" RELATED [NIST Chemistry WebBook:] synonym: "D-gluco-hexose" EXACT IUPAC_NAME [IUPAC:] synonym: "D-glucose" EXACT IUPAC_NAME [IUPAC:] synonym: "dextrose" RELATED [NIST Chemistry WebBook:] synonym: "grape sugar" RELATED [ChemIDplus:] synonym: "Traubenzucker" RELATED [ChemIDplus:] xref: ChemIDplus:50-99-7 "CAS Registry Number" xref: NIST Chemistry WebBook:50-99-7 "CAS Registry Number" is_a: CHEBI:17234 ! glucose is_a: CHEBI:17608 ! D-aldohexose property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17698 name: chloramphenicol namespace: chebi_ontology alt_id: CHEBI:13965 alt_id: CHEBI:23106 alt_id: CHEBI:23108 alt_id: CHEBI:3603 alt_id: CHEBI:47327 def: "An organochlorine compound that is dichloro-substituted acetamide containing a nitrobenzene ring, an amide bond and two alcohol functions." [] synonym: "2,2-dichloro-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide" EXACT IUPAC_NAME [IUPAC:] synonym: "C11H12Cl2N2O5" RELATED FORMULA [ChEBI:] synonym: "C11H12Cl2N2O5" RELATED FORMULA [KEGG COMPOUND:] synonym: "Chloramex" RELATED BRAND_NAME [ChemIDplus:] synonym: "CHLORAMPHENICOL" EXACT [PDBeChem:] synonym: "Chloramphenicol" EXACT [KEGG COMPOUND:] synonym: "chloramphenicol" EXACT [UniProt:] synonym: "chloramphenicol" RELATED INN [ChEBI:] synonym: "chloramphenicol" RELATED INN [ChemIDplus:] synonym: "chloramphenicols" RELATED [ChEBI:] synonym: "chloramphenicolum" RELATED INN [ChemIDplus:] synonym: "chlornitromycin" RELATED [ChEBI:] synonym: "Chlorocid" RELATED BRAND_NAME [ChemIDplus:] synonym: "Chlorocol" RELATED BRAND_NAME [ChemIDplus:] synonym: "Chloromycetin" RELATED BRAND_NAME [ChemIDplus:] synonym: "cloramfenicol" RELATED INN [ChemIDplus:] synonym: "D-(-)-2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenylethyl)acetamide" RELATED [ChemIDplus:] synonym: "D-(-)-threo-1-p-nitrophenyl-2-dichloroacetylamino-1,3-propanediol" RELATED [ChemIDplus:] synonym: "Fenicol" RELATED BRAND_NAME [ChemIDplus:] synonym: "Globenicol" RELATED BRAND_NAME [ChemIDplus:] synonym: "Halomycetin" RELATED BRAND_NAME [ChemIDplus:] synonym: "InChI=1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=WIIZWVCIJKGZOK-RKDXNWHRSA-N" RELATED InChIKey [ChEBI:] synonym: "laevomycetinum" RELATED [ChemIDplus:] synonym: "levomicetina" RELATED [ChemIDplus:] synonym: "levomycetin" RELATED [ChemIDplus:] synonym: "OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+]([O-])=O" RELATED SMILES [ChEBI:] synonym: "Oleomycetin" RELATED BRAND_NAME [ChemIDplus:] synonym: "Sificetina" RELATED BRAND_NAME [ChemIDplus:] xref: Beilstein:2225532 "Beilstein Registry Number" xref: ChEMBL:9917285 "PubMed citation" xref: ChemIDplus:56-75-7 "CAS Registry Number" xref: CiteXplore:11468347 "PubMed citation" xref: CiteXplore:12217690 "PubMed citation" xref: CiteXplore:16659995 "PubMed citation" xref: CiteXplore:16897441 "PubMed citation" xref: CiteXplore:17217404 "PubMed citation" xref: CiteXplore:17692887 "PubMed citation" xref: CiteXplore:18559535 "PubMed citation" xref: CiteXplore:18657290 "PubMed citation" xref: CiteXplore:18794387 "PubMed citation" xref: CiteXplore:23142491 "PubMed citation" xref: CiteXplore:23317719 "PubMed citation" xref: CiteXplore:23395526 "PubMed citation" xref: CiteXplore:23494278 "PubMed citation" xref: CiteXplore:23512826 "PubMed citation" xref: CiteXplore:657786 "PubMed citation" xref: CiteXplore:6653106 "PubMed citation" xref: DrugBank:DB00446 "DrugBank" xref: KEGG COMPOUND:56-75-7 "CAS Registry Number" xref: KEGG COMPOUND:C00918 "KEGG COMPOUND" xref: KEGG DRUG:D00104 "KEGG DRUG" xref: Patent:GB795131 "Patent" xref: Patent:GB796901 "Patent" xref: Patent:US2483871 "Patent" xref: Patent:US2483884 "Patent" xref: Patent:US2483892 "Patent" xref: Patent:US2839577 "Patent" xref: PDBeChem:CLM "PDBeChem" xref: Wikipedia:Chloramphenicol "Wikipedia" is_a: CHEBI:36683 ! organochlorine compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17754 name: glycerol namespace: chebi_ontology alt_id: CHEBI:131422 alt_id: CHEBI:14334 alt_id: CHEBI:24351 alt_id: CHEBI:42998 alt_id: CHEBI:5448 def: "A triol with a structure of propane substituted at positions 1, 2 and 3 by hydroxy groups." [] synonym: "1,2,3-Propanetriol" RELATED [KEGG COMPOUND:] synonym: "1,2,3-Trihydroxypropane" RELATED [KEGG COMPOUND:] synonym: "C3H8O3" RELATED FORMULA [KEGG COMPOUND:] synonym: "Glycerin" RELATED [KEGG COMPOUND:] synonym: "glycerine" RELATED [ChEBI:] synonym: "Glyceritol" RELATED [HMDB:] synonym: "GLYCEROL" EXACT [PDBeChem:] synonym: "Glycerol" EXACT [KEGG COMPOUND:] synonym: "glycerol" EXACT [ChEBI:] synonym: "glycerol" EXACT [UniProt:] synonym: "glycerol" RELATED INN [ChemIDplus:] synonym: "glycerolum" RELATED INN [ChemIDplus:] synonym: "glycyl alcohol" RELATED [NIST Chemistry WebBook:] synonym: "Glyzerin" RELATED [ChEBI:] synonym: "Gro" RELATED [JCBN:] synonym: "InChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2" RELATED InChI [ChEBI:] synonym: "InChIKey=PEDCQBHIVMGVHV-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "OCC(O)CO" RELATED SMILES [ChEBI:] synonym: "Oelsuess" RELATED [ChEBI:] synonym: "propane-1,2,3-triol" EXACT IUPAC_NAME [IUPAC:] synonym: "Propanetriol" RELATED [HMDB:] synonym: "Trihydroxypropane" RELATED [HMDB:] xref: Beilstein:635685 "Beilstein Registry Number" xref: ChEMBL:12672239 "PubMed citation" xref: ChEMBL:7031247 "PubMed citation" xref: ChEMBL:7392035 "PubMed citation" xref: ChemIDplus:56-81-5 "CAS Registry Number" xref: CiteXplore:11958517 "PubMed citation" xref: CiteXplore:12689633 "PubMed citation" xref: CiteXplore:14559393 "PubMed citation" xref: CiteXplore:14563847 "PubMed citation" xref: CiteXplore:15342117 "PubMed citation" xref: CiteXplore:15786693 "PubMed citation" xref: CiteXplore:16244855 "PubMed citation" xref: CiteXplore:16258193 "PubMed citation" xref: CiteXplore:16319039 "PubMed citation" xref: CiteXplore:16349488 "PubMed citation" xref: CiteXplore:16651733 "PubMed citation" xref: CiteXplore:16664750 "PubMed citation" xref: CiteXplore:16901854 "PubMed citation" xref: CiteXplore:17336832 "PubMed citation" xref: CiteXplore:17439666 "PubMed citation" xref: CiteXplore:17979222 "PubMed citation" xref: CiteXplore:19184438 "PubMed citation" xref: CiteXplore:19231894 "PubMed citation" xref: CiteXplore:19460032 "PubMed citation" xref: CiteXplore:19548674 "PubMed citation" xref: CiteXplore:19795216 "PubMed citation" xref: CiteXplore:19956799 "PubMed citation" xref: CiteXplore:22705534 "PubMed citation" xref: CiteXplore:23562176 "PubMed citation" xref: CiteXplore:23747440 "PubMed citation" xref: DrugBank:DB04077 "DrugBank" xref: ECMDB:ECMDB00131 "ECMDB" xref: Gmelin:26279 "Gmelin Registry Number" xref: HMDB:HMDB00131 "HMDB" xref: KEGG COMPOUND:56-81-5 "CAS Registry Number" xref: KEGG COMPOUND:C00116 "KEGG COMPOUND" xref: KEGG DRUG:D00028 "KEGG DRUG" xref: KNApSAcK:C00001163 "KNApSAcK" xref: MetaCyc:GLYCEROL "MetaCyc" xref: NIST Chemistry WebBook:56-81-5 "CAS Registry Number" xref: PDB:2AJS "PDB" xref: PDB:2D03 "PDB" xref: PDBeChem:GOL "PDBeChem" xref: Reaxys:635685 "Reaxys Registry Number" xref: UM-BBD:c0066 "UM-BBD compID" xref: Wikipedia:Glycerol "Wikipedia" xref: YMDB:YMDB00283 "YMDB" is_a: CHEBI:17522 ! alditol is_a: CHEBI:27136 ! triol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17822 name: serine namespace: chebi_ontology alt_id: CHEBI:15081 alt_id: CHEBI:26648 alt_id: CHEBI:9116 def: "An alpha-amino acid that is alanine substituted at position 3 by a hydroxy group." [] synonym: "2-amino-3-hydroxypropanoic acid" RELATED [IUPAC:] synonym: "2-Amino-3-hydroxypropionic acid" RELATED [KEGG COMPOUND:] synonym: "3-Hydroxyalanine" RELATED [KEGG COMPOUND:] synonym: "C3H7NO3" RELATED FORMULA [KEGG COMPOUND:] synonym: "InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)" RELATED InChI [ChEBI:] synonym: "InChIKey=MTCFGRXMJLQNBG-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "NC(CO)C(O)=O" RELATED SMILES [ChEBI:] synonym: "Serin" RELATED [ChEBI:] synonym: "Serine" EXACT [KEGG COMPOUND:] synonym: "serine" EXACT IUPAC_NAME [IUPAC:] xref: Beilstein:1721402 "Beilstein Registry Number" xref: ChemIDplus:302-84-1 "CAS Registry Number" xref: Gmelin:26429 "Gmelin Registry Number" xref: KEGG COMPOUND:302-84-1 "CAS Registry Number" xref: KEGG COMPOUND:C00716 "KEGG COMPOUND" xref: KNApSAcK:C00001393 "KNApSAcK" xref: NIST Chemistry WebBook:302-84-1 "CAS Registry Number" xref: Reaxys:1721402 "Reaxys Registry Number" xref: Wikipedia:Serine "Wikipedia" is_a: CHEBI:33704 ! alpha-amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17855 name: triglyceride namespace: chebi_ontology alt_id: CHEBI:15255 alt_id: CHEBI:27085 alt_id: CHEBI:9664 synonym: "[*]C(=O)OCC(COC([*])=O)OC([*])=O" RELATED SMILES [ChEBI:] synonym: "a triacylglycerol" RELATED [UniProt:] synonym: "C6H5O6R3" RELATED FORMULA [ChEBI:] synonym: "Triacylglycerol" RELATED [KEGG COMPOUND:] synonym: "triacylglycerols" RELATED [LIPID MAPS:] synonym: "Triglycerid" RELATED [ChEBI:] synonym: "Triglyceride" EXACT [KEGG COMPOUND:] synonym: "triglycerides" EXACT IUPAC_NAME [IUPAC:] synonym: "triglycerides" RELATED [ChEBI:] synonym: "Triglyzerid" RELATED [ChEBI:] xref: KEGG COMPOUND:C00422 "KEGG COMPOUND" xref: LIPID MAPS:LMGL0301 "LIPID MAPS class" is_a: CHEBI:47778 ! glyceride property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17858 name: glutathione disulfide namespace: chebi_ontology alt_id: CHEBI:14328 alt_id: CHEBI:14720 alt_id: CHEBI:24336 alt_id: CHEBI:42832 alt_id: CHEBI:7840 def: "A glutathione derivative that has formula C20H32N6O12S2." [] synonym: "(2S,2'S)-5,5'-[disulfanediylbis({(2R)-3-[(carboxymethyl)amino]-3-oxopropane-1,2-diyl}imino)]bis(2-amino-5-oxopentanoic acid)" EXACT IUPAC_NAME [IUPAC:] synonym: "(2S,2'S)-5,5'-[disulfanediylbis({(2R)-3-[(carboxymethyl)amino]-3-oxopropane-1,2-diyl}imino)]bis(2-amino-5-oxopentanoic acid) (non-preferred name)" RELATED [PDBeChem:] synonym: "C20H32N6O12S2" RELATED FORMULA [KEGG COMPOUND:] synonym: "Glutathione disulfide" EXACT [KEGG COMPOUND:] synonym: "glutathione disulphide" RELATED [ChemIDplus:] synonym: "GSSG" RELATED [KEGG COMPOUND:] synonym: "InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/t9-,10-,11-,12-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=YPZRWBKMTBYPTK-BJDJZHNGSA-N" RELATED InChIKey [ChEBI:] synonym: "N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O)C(=O)NCC(O)=O)C(O)=O" RELATED SMILES [ChEBI:] synonym: "oxidised glutathione" RELATED [ChEBI:] synonym: "Oxidized glutathione" RELATED [KEGG COMPOUND:] synonym: "OXIDIZED GLUTATHIONE DISULFIDE" RELATED [PDBeChem:] synonym: "Oxiglutatione" RELATED [KEGG COMPOUND:] xref: ChemIDplus:27025-41-8 "CAS Registry Number" xref: DrugBank:DB03310 "DrugBank" xref: KEGG COMPOUND:27025-41-8 "CAS Registry Number" xref: KEGG COMPOUND:C00127 "KEGG COMPOUND" xref: KEGG DRUG:D00031 "KEGG DRUG" xref: PDBeChem:GDS "PDBeChem" is_a: CHEBI:24337 ! glutathione derivative is_a: CHEBI:35489 ! organic disulfide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17895 name: L-tyrosine namespace: chebi_ontology alt_id: CHEBI:13181 alt_id: CHEBI:21411 alt_id: CHEBI:46070 alt_id: CHEBI:46161 alt_id: CHEBI:6313 def: "An optically active form of tyrosine having L-configuration." [] synonym: "(-)-alpha-amino-p-hydroxyhydrocinnamic acid" RELATED [NIST Chemistry WebBook:] synonym: "(2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid" RELATED [IUPAC:] synonym: "(S)-(-)-Tyrosine" RELATED [HMDB:] synonym: "(S)-2-Amino-3-(p-hydroxyphenyl)propionic acid" RELATED [KEGG COMPOUND:] synonym: "(S)-3-(p-Hydroxyphenyl)alanine" RELATED [KEGG COMPOUND:] synonym: "(S)-alpha-amino-4-hydroxybenzenepropanoic acid" RELATED [NIST Chemistry WebBook:] synonym: "(S)-Tyrosine" RELATED [HMDB:] synonym: "4-hydroxy-L-phenylalanine" RELATED [NIST Chemistry WebBook:] synonym: "C9H11NO3" RELATED FORMULA [KEGG COMPOUND:] synonym: "InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=OUYCCCASQSFEME-QMMMGPOBSA-N" RELATED InChIKey [ChEBI:] synonym: "L-Tyrosin" RELATED [ChEBI:] synonym: "L-Tyrosine" EXACT [PDBeChem:] synonym: "L-Tyrosine" EXACT [KEGG COMPOUND:] synonym: "L-tyrosine" EXACT IUPAC_NAME [IUPAC:] synonym: "N[C@@H](Cc1ccc(O)cc1)C(O)=O" RELATED SMILES [ChEBI:] synonym: "Tyr" RELATED [ChEBI:] synonym: "TYROSINE" RELATED [PDBeChem:] synonym: "Tyrosine" RELATED [KEGG COMPOUND:] synonym: "Y" RELATED [ChEBI:] xref: Beilstein:392441 "Beilstein Registry Number" xref: ChEBI:c0234 "UM-BBD compID" xref: ChemIDplus:60-18-4 "CAS Registry Number" xref: CiteXplore:15171683 "PubMed citation" xref: CiteXplore:22360849 "PubMed citation" xref: CiteXplore:22402312 "PubMed citation" xref: DrugBank:DB00135 "DrugBank" xref: ECMDB:ECMDB00158 "ECMDB" xref: Gmelin:50929 "Gmelin Registry Number" xref: HMDB:HMDB00158 "HMDB" xref: KEGG COMPOUND:60-18-4 "CAS Registry Number" xref: KEGG COMPOUND:C00082 "KEGG COMPOUND" xref: KEGG DRUG:D00022 "KEGG DRUG" xref: KNApSAcK:C00001397 "KNApSAcK" xref: MetaCyc:TYR "MetaCyc" xref: NIST Chemistry WebBook:60-18-4 "CAS Registry Number" xref: PDBeChem:TYR "PDBeChem" xref: Reaxys:392441 "Reaxys Registry Number" xref: Wikipedia:Tyrosine "Wikipedia" xref: YMDB:YMDB00364 "YMDB" is_a: CHEBI:18186 ! tyrosine is_a: CHEBI:73690 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid is_a: CHEBI:83813 ! proteinogenic amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17955 name: 2'-deoxyribonucleoside diphosphate namespace: chebi_ontology alt_id: CHEBI:11396 alt_id: CHEBI:19256 alt_id: CHEBI:838 synonym: "2'-Deoxyribonucleoside diphosphate" EXACT [KEGG COMPOUND:] synonym: "2'-deoxyribonucleoside diphosphate" EXACT [UniProt:] synonym: "2'-deoxyribonucleoside diphosphates" RELATED [ChEBI:] synonym: "C5H11O9P2R" RELATED FORMULA [KEGG COMPOUND:] xref: ChEBI:C03786 "KEGG COMPOUND" xref: KEGG COMPOUND:C04232 "KEGG COMPOUND" is_a: CHEBI:16862 ! nucleoside diphosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:17992 name: sucrose namespace: chebi_ontology alt_id: CHEBI:15128 alt_id: CHEBI:26812 alt_id: CHEBI:45795 alt_id: CHEBI:9314 def: "Sucrose is a disaccharide formed by glucose and fructose units joined by an acetal oxygen bridge from hemiacetal of glucose to the hemiketal of the fructose." [] synonym: "1-alpha-D-Glucopyranosyl-2-beta-D-fructofuranoside" RELATED [KEGG COMPOUND:] synonym: "beta-D-fructofuranosyl alpha-D-glucopyranoside" EXACT IUPAC_NAME [IUPAC:] synonym: "beta-D-Fruf-(2<->1)-alpha-D-Glcp" RELATED [JCBN:] synonym: "C12H22O11" RELATED FORMULA [KEGG COMPOUND:] synonym: "Cane sugar" RELATED [KEGG COMPOUND:] synonym: "InChI=1S/C12H22O11/c13-1-4-6(16)8(18)9(19)11(21-4)23-12(3-15)10(20)7(17)5(2-14)22-12/h4-11,13-20H,1-3H2/t4-,5-,6-,7-,8+,9-,10+,11-,12+/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=CZMRCDWAGMRECN-UGDNZRGBSA-N" RELATED InChIKey [ChEBI:] synonym: "OC[C@H]1O[C@H](O[C@]2(CO)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O" RELATED SMILES [ChEBI:] synonym: "sacarosa" RELATED [ChEBI:] synonym: "Saccharose" RELATED [KEGG COMPOUND:] synonym: "Sacharose" RELATED [ChEBI:] synonym: "SUCROSE" EXACT [PDBeChem:] synonym: "Sucrose" EXACT [KEGG COMPOUND:] synonym: "sucrose" EXACT [UniProt:] synonym: "table sugar" RELATED [ChemIDplus:] synonym: "White sugar" RELATED [HMDB:] xref: Beilstein:90825 "Beilstein Registry Number" xref: ChemIDplus:57-50-1 "CAS Registry Number" xref: CiteXplore:11021636 "PubMed citation" xref: CiteXplore:11093712 "PubMed citation" xref: CiteXplore:11111003 "PubMed citation" xref: CiteXplore:12065720 "PubMed citation" xref: CiteXplore:12706980 "PubMed citation" xref: CiteXplore:13508893 "PubMed citation" xref: CiteXplore:15291457 "PubMed citation" xref: CiteXplore:15660210 "PubMed citation" xref: CiteXplore:15792978 "PubMed citation" xref: CiteXplore:15845855 "PubMed citation" xref: CiteXplore:16228482 "PubMed citation" xref: CiteXplore:16304615 "PubMed citation" xref: CiteXplore:16313996 "PubMed citation" xref: CiteXplore:16525719 "PubMed citation" xref: CiteXplore:16660545 "PubMed citation" xref: CiteXplore:16663947 "PubMed citation" xref: CiteXplore:16665852 "PubMed citation" xref: CiteXplore:17233733 "PubMed citation" xref: CiteXplore:17439666 "PubMed citation" xref: CiteXplore:17597061 "PubMed citation" xref: CiteXplore:18625236 "PubMed citation" xref: CiteXplore:19199566 "PubMed citation" xref: CiteXplore:19726178 "PubMed citation" xref: CiteXplore:21703290 "PubMed citation" xref: CiteXplore:21972845 "PubMed citation" xref: CiteXplore:22085755 "PubMed citation" xref: CiteXplore:22311778 "PubMed citation" xref: CiteXplore:22404833 "PubMed citation" xref: CiteXplore:22751876 "PubMed citation" xref: DrugBank:DB02772 "DrugBank" xref: Gmelin:97695 "Gmelin Registry Number" xref: HMDB:HMDB00258 "HMDB" xref: KEGG COMPOUND:57-50-1 "CAS Registry Number" xref: KEGG COMPOUND:C00089 "KEGG COMPOUND" xref: KEGG DRUG:D00025 "KEGG DRUG" xref: KEGG DRUG:D06533 "KEGG DRUG" xref: KEGG GLYCAN:G00370 "KEGG GLYCAN" xref: KNApSAcK:C00001151 "KNApSAcK" xref: MetaCyc:SUCROSE "MetaCyc" xref: NIST Chemistry WebBook:57-50-1 "CAS Registry Number" xref: PDBeChem:SUC "PDBeChem" xref: Reaxys:1435311 "Reaxys Registry Number" xref: Reaxys:90825 "Reaxys Registry Number" xref: Wikipedia:Sucrose "Wikipedia" is_a: CHEBI:24407 ! glycosyl glycoside property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:18019 name: L-lysine namespace: chebi_ontology alt_id: CHEBI:13135 alt_id: CHEBI:21351 alt_id: CHEBI:43950 alt_id: CHEBI:6264 def: "An L-alpha-amino acid; the L-isomer of lysine." [] synonym: "(2S)-2,6-diaminohexanoic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "(S)-2,6-diaminohexanoic acid" RELATED [NIST Chemistry WebBook:] synonym: "(S)-alpha,epsilon-diaminocaproic acid" RELATED [NIST Chemistry WebBook:] synonym: "(S)-lysine" RELATED [NIST Chemistry WebBook:] synonym: "6-ammonio-L-norleucine" RELATED [PDBeChem:] synonym: "C6H14N2O2" RELATED FORMULA [KEGG COMPOUND:] synonym: "C6H15N2O2" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/t5-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=KDXKERNSBIXSRK-YFKPBYRVSA-N" RELATED InChIKey [ChEBI:] synonym: "K" RELATED [NIST Chemistry WebBook:] synonym: "L-2,6-Diaminocaproic acid" RELATED [HMDB:] synonym: "L-Lysin" RELATED [ChEBI:] synonym: "L-Lysine" EXACT [KEGG COMPOUND:] synonym: "L-lysine" EXACT IUPAC_NAME [IUPAC:] synonym: "Lys" RELATED [NIST Chemistry WebBook:] synonym: "LYSINE" RELATED [PDBeChem:] synonym: "Lysine acid" RELATED [KEGG COMPOUND:] synonym: "NCCCC[C@H](N)C(O)=O" RELATED SMILES [ChEBI:] xref: Beilstein:1722531 "Beilstein Registry Number" xref: ChemIDplus:56-87-1 "CAS Registry Number" xref: CiteXplore:10930630 "PubMed citation" xref: CiteXplore:16901854 "PubMed citation" xref: CiteXplore:17051348 "PubMed citation" xref: CiteXplore:17979222 "PubMed citation" xref: CiteXplore:22019452 "PubMed citation" xref: CiteXplore:22064742 "PubMed citation" xref: CiteXplore:22575419 "PubMed citation" xref: CiteXplore:22735334 "PubMed citation" xref: CiteXplore:23167968 "PubMed citation" xref: CiteXplore:23325920 "PubMed citation" xref: CiteXplore:23722415 "PubMed citation" xref: CiteXplore:24064214 "PubMed citation" xref: CiteXplore:24831709 "PubMed citation" xref: CiteXplore:8070089 "PubMed citation" xref: CiteXplore:8587651 "PubMed citation" xref: DrugBank:DB00123 "DrugBank" xref: ECMDB:ECMDB00182 "ECMDB" xref: Gmelin:364182 "Gmelin Registry Number" xref: HMDB:HMDB00182 "HMDB" xref: KEGG COMPOUND:56-87-1 "CAS Registry Number" xref: KEGG COMPOUND:C00047 "KEGG COMPOUND" xref: KEGG DRUG:D02304 "KEGG DRUG" xref: KNApSAcK:C00001378 "KNApSAcK" xref: MetaCyc:LYS "MetaCyc" xref: NIST Chemistry WebBook:56-87-1 "CAS Registry Number" xref: Reaxys:1722531 "Reaxys Registry Number" xref: Wikipedia:Lysine "Wikipedia" xref: YMDB:YMDB00330 "YMDB" is_a: CHEBI:22658 ! aspartate family amino acid is_a: CHEBI:25094 ! lysine is_a: CHEBI:83813 ! proteinogenic amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:18035 name: diglyceride namespace: chebi_ontology alt_id: CHEBI:14135 alt_id: CHEBI:23653 alt_id: CHEBI:4481 def: "A glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group." [] synonym: "[*]OCC(CO[*])O[*]" RELATED SMILES [ChEBI:] synonym: "a diacylglycerol" RELATED [UniProt:] synonym: "C5H6O5R2" RELATED FORMULA [KEGG COMPOUND:] synonym: "di-O-acylglycerols" RELATED [ChEBI:] synonym: "Diacylglycerol" RELATED [KEGG COMPOUND:] synonym: "diacylglycerols" RELATED [LIPID MAPS:] synonym: "Diglyceride" EXACT [KEGG COMPOUND:] synonym: "diglycerides" EXACT IUPAC_NAME [IUPAC:] synonym: "diglycerides" RELATED [ChEBI:] xref: KEGG COMPOUND:C00165 "KEGG COMPOUND" xref: LIPID MAPS:LMGL0201 "LIPID MAPS class" is_a: CHEBI:47778 ! glyceride is_a: CHEBI:76578 ! disubstituted glycerol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:18050 name: L-glutamine namespace: chebi_ontology alt_id: CHEBI:13110 alt_id: CHEBI:21308 alt_id: CHEBI:42812 alt_id: CHEBI:42814 alt_id: CHEBI:42899 alt_id: CHEBI:42943 alt_id: CHEBI:6227 def: "An optically active form of glutamine having L-configuration." [] synonym: "(2S)-2,5-diamino-5-oxopentanoic acid" RELATED [IUPAC:] synonym: "(2S)-2-amino-4-carbamoylbutanoic acid" RELATED [JCBN:] synonym: "(S)-2,5-diamino-5-oxopentanoic acid" RELATED [ChEBI:] synonym: "C5H10N2O3" RELATED FORMULA [KEGG COMPOUND:] synonym: "Glutamic acid 5-amide" RELATED [HMDB:] synonym: "Glutamic acid amide" RELATED [HMDB:] synonym: "GLUTAMINE" RELATED [PDBeChem:] synonym: "InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=ZDXPYRJPNDTMRX-VKHMYHEASA-N" RELATED InChIKey [ChEBI:] synonym: "L-(+)-glutamine" RELATED [ChemIDplus:] synonym: "L-2-Aminoglutaramic acid" RELATED [KEGG COMPOUND:] synonym: "L-2-aminoglutaramic acid" RELATED [ChEBI:] synonym: "L-2-aminoglutaramic acid" RELATED [DrugBank:] synonym: "L-glutamic acid gamma-amide" RELATED [NIST Chemistry WebBook:] synonym: "L-Glutamin" RELATED [ChEBI:] synonym: "L-Glutamine" EXACT [KEGG COMPOUND:] synonym: "L-glutamine" EXACT IUPAC_NAME [IUPAC:] synonym: "L-Glutaminsaeure-5-amid" RELATED [ChEBI:] synonym: "Levoglutamide" RELATED [KEGG DRUG:] synonym: "N[C@@H](CCC(N)=O)C(O)=O" RELATED SMILES [ChEBI:] synonym: "Q" RELATED [ChEBI:] xref: ChemIDplus:1723797 "Beilstein Registry Number" xref: ChemIDplus:56-85-9 "CAS Registry Number" xref: CiteXplore:11139387 "PubMed citation" xref: CiteXplore:15204730 "PubMed citation" xref: CiteXplore:22055478 "PubMed citation" xref: CiteXplore:22206385 "PubMed citation" xref: CiteXplore:22451274 "PubMed citation" xref: CiteXplore:22453904 "PubMed citation" xref: CiteXplore:22575040 "PubMed citation" xref: CiteXplore:22770225 "PubMed citation" xref: DrugBank:DB00130 "DrugBank" xref: ECMDB:ECMDB00641 "ECMDB" xref: Gmelin:3509 "Gmelin Registry Number" xref: HMDB:HMDB00641 "HMDB" xref: KEGG COMPOUND:56-85-9 "CAS Registry Number" xref: KEGG COMPOUND:C00064 "KEGG COMPOUND" xref: KEGG DRUG:D00015 "KEGG DRUG" xref: KNApSAcK:C00001359 "KNApSAcK" xref: MetaCyc:GLN "MetaCyc" xref: NIST Chemistry WebBook:56-85-9 "CAS Registry Number" xref: PDBeChem:GLN "PDBeChem" xref: Reaxys:1723797 "Reaxys Registry Number" xref: Wikipedia:Glutamine "Wikipedia" xref: YMDB:YMDB00002 "YMDB" is_a: CHEBI:24318 ! glutamine family amino acid is_a: CHEBI:28300 ! glutamine is_a: CHEBI:83813 ! proteinogenic amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:18059 name: lipid namespace: chebi_ontology alt_id: CHEBI:14517 alt_id: CHEBI:25054 alt_id: CHEBI:6486 def: "'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "Lipid" EXACT [KEGG COMPOUND:] synonym: "lipid" EXACT [UniProt:] synonym: "lipids" EXACT IUPAC_NAME [IUPAC:] xref: KEGG COMPOUND:C01356 "KEGG COMPOUND" is_a: CHEBI:50860 ! organic molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:18075 name: dTDP namespace: chebi_ontology alt_id: CHEBI:10500 alt_id: CHEBI:14077 alt_id: CHEBI:26998 alt_id: CHEBI:46061 def: "A thymidine phosphate having a diphosphate group at the 5'-position." [] synonym: "2'-deoxyribosylthymine 5'-(trihydrogen diphosphate)" RELATED [ChEBI:] synonym: "C10H16N2O11P2" RELATED FORMULA [KEGG COMPOUND:] synonym: "Cc1cn([C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP(O)(O)=O)O2)c(=O)[nH]c1=O" RELATED SMILES [ChEBI:] synonym: "deoxy-TDP" RELATED [ChemIDplus:] synonym: "Deoxythymidine 5'-diphosphate" RELATED [KEGG COMPOUND:] synonym: "dTDP" EXACT [KEGG COMPOUND:] synonym: "InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/t6-,7+,8+/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=UJLXYODCHAELLY-XLPZGREQSA-N" RELATED InChIKey [ChEBI:] synonym: "thymidine 5'-(trihydrogen diphosphate)" EXACT IUPAC_NAME [IUPAC:] synonym: "thymidine 5'-(trihydrogen diphosphate)" RELATED [PDBeChem:] synonym: "thymidine 5'-diphosphate" RELATED [ChemIDplus:] synonym: "thymidine 5'-pyrophosphate" RELATED [ChemIDplus:] synonym: "THYMIDINE-5'- DIPHOSPHATE" RELATED [PDBeChem:] xref: Beilstein:64132 "Beilstein Registry Number" xref: ChemIDplus:491-97-4 "CAS Registry Number" xref: CiteXplore:20065942 "PubMed citation" xref: CiteXplore:23394555 "PubMed citation" xref: DrugBank:DB03103 "DrugBank" xref: HMDB:HMDB01274 "HMDB" xref: KEGG COMPOUND:491-97-4 "CAS Registry Number" xref: KEGG COMPOUND:C00363 "KEGG COMPOUND" xref: KNApSAcK:C00019696 "KNApSAcK" xref: MetaCyc:TDP "MetaCyc" xref: PDBeChem:TYD "PDBeChem" xref: Wikipedia:Thymidine_diphosphate "Wikipedia" is_a: CHEBI:27001 ! thymidine phosphate is_a: CHEBI:37037 ! pyrimidine 2'-deoxyribonucleoside 5'-diphosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:18077 name: dTTP namespace: chebi_ontology alt_id: CHEBI:10530 alt_id: CHEBI:14093 alt_id: CHEBI:27000 alt_id: CHEBI:46175 def: "A pyrimidine 2'-deoxyribonucleoside 5'-triphosphate that has formula C10H17N2O14P3." [] synonym: "2'-deoxythymidine triphosphate" RELATED [ChemIDplus:] synonym: "5'-TTP" RELATED [ChemIDplus:] synonym: "C10H17N2O14P3" RELATED FORMULA [KEGG COMPOUND:] synonym: "Cc1cn([C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)[nH]c1=O" RELATED SMILES [ChEBI:] synonym: "deoxy-TTP" RELATED [ChemIDplus:] synonym: "Deoxythymidine 5'-triphosphate" RELATED [KEGG COMPOUND:] synonym: "Deoxythymidine triphosphate" RELATED [KEGG COMPOUND:] synonym: "dThd5'PPP" RELATED [CBN:] synonym: "dTTP" EXACT [KEGG COMPOUND:] synonym: "InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/t6-,7+,8+/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=NHVNXKFIZYSCEB-XLPZGREQSA-N" RELATED InChIKey [ChEBI:] synonym: "pppdT" RELATED [CBN:] synonym: "thymidine 5'-(tetrahydrogen triphosphate)" EXACT IUPAC_NAME [IUPAC:] synonym: "thymidine 5'-(tetrahydrogen triphosphate)" RELATED [PDBeChem:] synonym: "thymidine 5'-triphosphate" RELATED [ChemIDplus:] synonym: "THYMIDINE-5'-TRIPHOSPHATE" RELATED [PDBeChem:] synonym: "TTP" RELATED [KEGG COMPOUND:] xref: Beilstein:71453 "Beilstein Registry Number" xref: ChemIDplus:365-08-2 "CAS Registry Number" xref: DrugBank:DB02452 "DrugBank" xref: KEGG COMPOUND:C00459 "KEGG COMPOUND" xref: KNApSAcK:C00019695 "KNApSAcK" xref: PDBeChem:TTP "PDBeChem" xref: Wikipedia:Deoxythymidine_Triphosphate "Wikipedia" is_a: CHEBI:27001 ! thymidine phosphate is_a: CHEBI:37043 ! pyrimidine 2'-deoxyribonucleoside 5'-triphosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:18087 name: myo-inositol polyphosphate namespace: chebi_ontology alt_id: CHEBI:10604 alt_id: CHEBI:12833 synonym: "." RELATED FORMULA [ChEBI:] synonym: "myo-Inositol polyphosphate" EXACT [KEGG COMPOUND:] synonym: "myo-inositol polyphosphate" EXACT [UniProt:] synonym: "myo-inositol polyphosphates" RELATED [ChEBI:] xref: KEGG COMPOUND:C11525 "KEGG COMPOUND" is_a: CHEBI:25448 ! myo-inositol phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:18133 name: hexose namespace: chebi_ontology alt_id: CHEBI:14399 alt_id: CHEBI:24590 alt_id: CHEBI:5709 def: "Any six-carbon monosaccharide which in its linear form contains either an aldehyde group at position 1 (aldohexose) or a ketone group at position 2 (ketohexose)." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "Hexose" EXACT [KEGG COMPOUND:] synonym: "hexose" EXACT [UniProt:] synonym: "hexoses" RELATED [ChEBI:] xref: KEGG COMPOUND:C00738 "KEGG COMPOUND" is_a: CHEBI:35381 ! monosaccharide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:18154 name: polysaccharide namespace: chebi_ontology alt_id: CHEBI:14864 alt_id: CHEBI:26205 alt_id: CHEBI:8322 def: "A biomacromolecule consisting of large numbers of monosaccharide residues linked glycosidically. This term is commonly used only for those containing more than ten monosaccharide residues." [] synonym: "Glycan" RELATED [KEGG COMPOUND:] synonym: "Glycane" RELATED [ChEBI:] synonym: "glycans" RELATED [IUPAC:] synonym: "Glykan" RELATED [ChEBI:] synonym: "Glykane" RELATED [ChEBI:] synonym: "polisacarido" RELATED [ChEBI:] synonym: "polisacaridos" RELATED [IUPAC:] synonym: "Polysaccharide" EXACT [KEGG COMPOUND:] synonym: "polysaccharide" EXACT [UniProt:] synonym: "polysaccharides" EXACT IUPAC_NAME [IUPAC:] xref: KEGG COMPOUND:C00420 "KEGG COMPOUND" is_a: CHEBI:16646 ! carbohydrate is_a: CHEBI:33694 ! biomacromolecule property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:18179 name: phosphoinositide namespace: chebi_ontology alt_id: CHEBI:14806 alt_id: CHEBI:60751 alt_id: CHEBI:8132 def: "Any phosphatidylinositol that is phosphorylated at one or more of the hydroxy groups of inositol." [] synonym: "C11H17O13PR2" RELATED FORMULA [KEGG COMPOUND:] synonym: "Phosphatidylinositol" RELATED [KEGG COMPOUND:] synonym: "phosphatidylinositol" RELATED [UniProt:] xref: CiteXplore:10782093 "PubMed citation" xref: CiteXplore:15269334 "PubMed citation" xref: CiteXplore:17035995 "PubMed citation" xref: CiteXplore:19154715 "PubMed citation" xref: KEGG COMPOUND:C00626 "KEGG COMPOUND" is_a: CHEBI:28874 ! phosphatidylinositol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:18186 name: tyrosine namespace: chebi_ontology alt_id: CHEBI:15277 alt_id: CHEBI:27176 alt_id: CHEBI:9800 def: "An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring." [] synonym: "2-amino-3-(4-hydroxyphenyl)propanoic acid" RELATED [IUPAC:] synonym: "2-Amino-3-(p-hydroxyphenyl)propionic acid" RELATED [KEGG COMPOUND:] synonym: "3-(p-Hydroxyphenyl)alanine" RELATED [KEGG COMPOUND:] synonym: "C9H11NO3" RELATED FORMULA [KEGG COMPOUND:] synonym: "InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)" RELATED InChI [ChEBI:] synonym: "InChIKey=OUYCCCASQSFEME-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "NC(Cc1ccc(O)cc1)C(O)=O" RELATED SMILES [ChEBI:] synonym: "tirosina" RELATED [ChEBI:] synonym: "Tyr" RELATED [ChEBI:] synonym: "Tyrosin" RELATED [ChEBI:] synonym: "Tyrosine" EXACT [KEGG COMPOUND:] synonym: "tyrosine" EXACT [UniProt:] synonym: "tyrosine" EXACT IUPAC_NAME [IUPAC:] synonym: "Y" RELATED [ChEBI:] xref: Beilstein:515881 "Beilstein Registry Number" xref: ChemIDplus:55520-40-6 "CAS Registry Number" xref: CiteXplore:17190852 "PubMed citation" xref: Gmelin:27744 "Gmelin Registry Number" xref: KEGG COMPOUND:556-03-6 "CAS Registry Number" xref: KEGG COMPOUND:C01536 "KEGG COMPOUND" xref: KNApSAcK:C00001397 "KNApSAcK" xref: Reaxys:515881 "Reaxys Registry Number" is_a: CHEBI:33704 ! alpha-amino acid is_a: CHEBI:33856 ! aromatic amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:18211 name: citrulline namespace: chebi_ontology alt_id: CHEBI:14002 alt_id: CHEBI:3730 def: "The parent compound of the citrulline class consisting of ornithine having a carbamoyl group at the N(5)-position." [] synonym: "2-amino-5-(carbamoylamino)pentanoic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "2-Amino-5-uredovaleric acid" RELATED [KEGG COMPOUND:] synonym: "C6H13N3O3" RELATED FORMULA [KEGG COMPOUND:] synonym: "Cit" RELATED [IUPAC:] synonym: "citrulina" RELATED [ChEBI:] synonym: "Citrullin" RELATED [ChEBI:] synonym: "Citrulline" EXACT [KEGG COMPOUND:] synonym: "citrulline" EXACT [UniProt:] synonym: "citrulline" EXACT IUPAC_NAME [IUPAC:] synonym: "DL-2-amino-5-ureidovaleric acid" RELATED [ChemIDplus:] synonym: "dl-citrulline" RELATED [NIST Chemistry WebBook:] synonym: "InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)" RELATED InChI [ChEBI:] synonym: "InChIKey=RHGKLRLOHDJJDR-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "N(5)-(aminocarbonyl)-DL-ornithine" RELATED [NIST Chemistry WebBook:] synonym: "N(5)-(aminocarbonyl)ornithine" RELATED [ChEBI:] synonym: "N(5)-carbamoyl-DL-ornithine" RELATED [NIST Chemistry WebBook:] synonym: "N(5)-carbamoylornithine" EXACT IUPAC_NAME [IUPAC:] synonym: "NC(CCCNC(N)=O)C(O)=O" RELATED SMILES [ChEBI:] xref: Beilstein:1725417 "Beilstein Registry Number" xref: Beilstein:2328251 "Beilstein Registry Number" xref: ChemIDplus:627-77-0 "CAS Registry Number" xref: CiteXplore:11094453 "PubMed citation" xref: CiteXplore:11113071 "PubMed citation" xref: CiteXplore:11696417 "PubMed citation" xref: CiteXplore:1378088 "PubMed citation" xref: CiteXplore:16082501 "PubMed citation" xref: CiteXplore:16708633 "PubMed citation" xref: CiteXplore:17005970 "PubMed citation" xref: CiteXplore:17513438 "PubMed citation" xref: CiteXplore:17558653 "PubMed citation" xref: CiteXplore:17693747 "PubMed citation" xref: CiteXplore:18437289 "PubMed citation" xref: CiteXplore:18440672 "PubMed citation" xref: CiteXplore:18989563 "PubMed citation" xref: CiteXplore:19144577 "PubMed citation" xref: CiteXplore:21129371 "PubMed citation" xref: CiteXplore:21482070 "PubMed citation" xref: NIST Chemistry WebBook:627-77-0 "CAS Registry Number" xref: Reaxys:1725417 "Reaxys Registry Number" xref: Wikipedia:Citrulline "Wikipedia" is_a: CHEBI:23324 ! citrullines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:18212 name: selenite(2-) namespace: chebi_ontology alt_id: CHEBI:15077 alt_id: CHEBI:9090 def: "A selenium oxoanion that has formula O3Se." [] synonym: "[O-][Se]([O-])=O" RELATED SMILES [ChEBI:] synonym: "[SeO3](2-)" RELATED [IUPAC:] synonym: "InChI=1S/H2O3Se/c1-4(2)3/h(H2,1,2,3)/p-2" RELATED InChI [ChEBI:] synonym: "InChIKey=MCAHWIHFGHIESP-UHFFFAOYSA-L" RELATED InChIKey [ChEBI:] synonym: "O3Se" RELATED FORMULA [KEGG COMPOUND:] synonym: "Selenit" RELATED [ChEBI:] synonym: "Selenite" RELATED [KEGG COMPOUND:] synonym: "selenite" EXACT IUPAC_NAME [IUPAC:] synonym: "selenite" RELATED [UniProt:] synonym: "trioxidoselenate(2-)" EXACT IUPAC_NAME [IUPAC:] synonym: "trioxoselenate(2-)" EXACT IUPAC_NAME [IUPAC:] synonym: "trioxoselenate(IV)" EXACT IUPAC_NAME [IUPAC:] xref: ChemIDplus:14124-67-5 "CAS Registry Number" xref: Gmelin:100833 "Gmelin Registry Number" xref: KEGG COMPOUND:C05684 "KEGG COMPOUND" xref: UM-BBD:c0741 "UM-BBD compID" is_a: CHEBI:33488 ! selenium oxoanion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:18254 name: ribonucleoside namespace: chebi_ontology alt_id: CHEBI:13014 alt_id: CHEBI:13015 alt_id: CHEBI:13685 alt_id: CHEBI:21085 alt_id: CHEBI:26560 alt_id: CHEBI:4240 alt_id: CHEBI:8844 def: "Any nucleoside where the sugar component is D-ribose." [] synonym: "a ribonucleoside" RELATED [UniProt:] synonym: "C5H9O4R" RELATED FORMULA [ChEBI:] synonym: "D-Ribosyl-base" RELATED [KEGG COMPOUND:] synonym: "D-ribosyl-base" RELATED [ChEBI:] synonym: "D-Ribosyl-base1" RELATED [KEGG COMPOUND:] synonym: "D-Ribosyl-base2" RELATED [KEGG COMPOUND:] synonym: "OC[C@H]1O[C@@H]([*])[C@H](O)[C@@H]1O" RELATED SMILES [ChEBI:] synonym: "Ribonucleoside" EXACT [KEGG COMPOUND:] synonym: "ribonucleosides" RELATED [ChEBI:] xref: KEGG COMPOUND:C00911 "KEGG COMPOUND" xref: KEGG COMPOUND:C02142 "KEGG COMPOUND" is_a: CHEBI:33838 ! nucleoside is_a: CHEBI:47019 ! dihydroxytetrahydrofuran property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:18257 name: ornithine namespace: chebi_ontology alt_id: CHEBI:7784 def: "An alpha-amino acid that is pentanoic acid bearing two amino substituents at positions 2 and 5." [] synonym: "2,5-Diaminopentanoic acid" RELATED [KEGG COMPOUND:] synonym: "2,5-diaminopentanoic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "2,5-Diaminovaleric acid" RELATED [KEGG COMPOUND:] synonym: "C5H12N2O2" RELATED FORMULA [KEGG COMPOUND:] synonym: "DL-Ornithine" RELATED [ChemIDplus:] synonym: "InChI=1S/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9)" RELATED InChI [ChEBI:] synonym: "InChIKey=AHLPHDHHMVZTML-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "NCCCC(N)C(O)=O" RELATED SMILES [ChEBI:] synonym: "Orn" RELATED [IUPAC:] synonym: "Ornithine" EXACT [KEGG COMPOUND:] synonym: "ornithine" EXACT IUPAC_NAME [IUPAC:] xref: Beilstein:1722296 "Beilstein Registry Number" xref: ChemIDplus:616-07-9 "CAS Registry Number" xref: CiteXplore:15449570 "PubMed citation" xref: CiteXplore:17190852 "PubMed citation" xref: CiteXplore:22264337 "PubMed citation" xref: Gmelin:847696 "Gmelin Registry Number" xref: KEGG COMPOUND:C01602 "KEGG COMPOUND" xref: KNApSAcK:C00001384 "KNApSAcK" xref: Reaxys:1722296 "Reaxys Registry Number" is_a: CHEBI:33704 ! alpha-amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:18282 name: nucleobase namespace: chebi_ontology alt_id: CHEBI:13873 alt_id: CHEBI:25598 alt_id: CHEBI:2995 def: "That part of DNA or RNA that may be involved in pairing." [] synonym: "a nucleobase" RELATED [UniProt:] synonym: "Base" RELATED [KEGG COMPOUND:] synonym: "Base1" RELATED [KEGG COMPOUND:] synonym: "Base2" RELATED [KEGG COMPOUND:] synonym: "nucleobases" RELATED [ChEBI:] xref: KEGG COMPOUND:C00701 "KEGG COMPOUND" xref: Wikipedia:Nucleobase "Wikipedia" is_a: CHEBI:38101 ! organonitrogen heterocyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:18283 name: alpha,alpha-trehalose 6-phosphate namespace: chebi_ontology alt_id: CHEBI:10201 alt_id: CHEBI:12285 alt_id: CHEBI:15252 alt_id: CHEBI:22364 def: "A trehalose phosphate that has formula C12H23O14P." [] synonym: "alpha,alpha'-Trehalose 6-phosphate" RELATED [KEGG COMPOUND:] synonym: "alpha-D-glucopyranosyl 6-O-phosphono-alpha-D-glucopyranoside" EXACT IUPAC_NAME [IUPAC:] synonym: "alpha-D-glucopyranosyl alpha-D-glucopyranoside 6-(dihydrogen phosphate)" RELATED [ChemIDplus:] synonym: "C12H23O14P" RELATED FORMULA [KEGG COMPOUND:] synonym: "InChI=1S/C12H23O14P/c13-1-3-5(14)7(16)9(18)11(24-3)26-12-10(19)8(17)6(15)4(25-12)2-23-27(20,21)22/h3-19H,1-2H2,(H2,20,21,22)/t3-,4-,5-,6-,7+,8+,9-,10-,11-,12-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=LABSPYBHMPDTEL-LIZSDCNHSA-N" RELATED InChIKey [ChEBI:] synonym: "OC[C@H]1O[C@H](O[C@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O" RELATED SMILES [ChEBI:] synonym: "Trehalose 6-phosphate" RELATED [KEGG COMPOUND:] xref: Beilstein:59815 "Beilstein Registry Number" xref: ChemIDplus:4484-88-2 "CAS Registry Number" xref: DrugBank:DB02430 "DrugBank" xref: KEGG COMPOUND:4484-88-2 "CAS Registry Number" xref: KEGG COMPOUND:C00689 "KEGG COMPOUND" xref: KEGG GLYCAN:G09795 "KEGG GLYCAN" xref: KNApSAcK:C00007451 "KNApSAcK" is_a: CHEBI:27084 ! trehalose phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:18303 name: phosphatidyl-L-serine namespace: chebi_ontology alt_id: CHEBI:14801 alt_id: CHEBI:26041 alt_id: CHEBI:8137 def: "A class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxy group of serine." [] synonym: "C8H12NO10PR2" RELATED FORMULA [ChEBI:] synonym: "N[C@@H](COP(O)(=O)OCC(COC([*])=O)OC([*])=O)C(O)=O" RELATED SMILES [ChEBI:] synonym: "phosphatidyl-L-serines" RELATED [ChEBI:] synonym: "Phosphatidylserine" RELATED [KEGG COMPOUND:] synonym: "PS" RELATED [ChEBI:] synonym: "Ptd-L-Ser" RELATED [ChEBI:] xref: CiteXplore:10540156 "PubMed citation" xref: CiteXplore:15533308 "PubMed citation" xref: CiteXplore:19687511 "PubMed citation" xref: CiteXplore:23543734 "PubMed citation" xref: CiteXplore:3106116 "PubMed citation" xref: CiteXplore:3196084 "PubMed citation" xref: CiteXplore:4153523 "PubMed citation" xref: CiteXplore:8204602 "PubMed citation" xref: CiteXplore:8626656 "PubMed citation" xref: CiteXplore:9677350 "PubMed citation" xref: DrugBank:DB00144 "DrugBank" xref: HMDB:HMDB14291 "HMDB" xref: KEGG COMPOUND:C02737 "KEGG COMPOUND" xref: MetaCyc:L-1-PHOSPHATIDYL-SERINE "MetaCyc" xref: Patent:EP2322184 "Patent" xref: Patent:HK1046237 "Patent" xref: Patent:US2011098249 "Patent" xref: Wikipedia:Phosphatidylserine "Wikipedia" is_a: CHEBI:52565 ! acylglycerophosphoserine is_a: CHEBI:60971 ! aminophospholipid is_a: CHEBI:84135 ! L-serine derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:18320 name: 1,4-dithiothreitol namespace: chebi_ontology alt_id: CHEBI:11174 alt_id: CHEBI:23854 alt_id: CHEBI:4664 def: "The threo-diastereomer of 1,4-dimercaptobutane-2,3-diol." [] synonym: "(R*,R*)-1,4-dimercapto-2,3-butanediol" RELATED [NIST Chemistry WebBook:] synonym: "1,4-Dithiothreitol" EXACT [KEGG COMPOUND:] synonym: "1,4-dithiothreitol" EXACT [UniProt:] synonym: "C4H10O2S2" RELATED FORMULA [KEGG COMPOUND:] synonym: "Cleland's reagent" RELATED [NIST Chemistry WebBook:] synonym: "Dithiothreitol" RELATED [KEGG COMPOUND:] synonym: "Dithiotreitol" RELATED [ChemIDplus:] synonym: "DL-threo-1,4-Dimercapto-2,3-butanediol" RELATED [ChemIDplus:] synonym: "DTL" RELATED [ChEBI:] synonym: "DTT" RELATED [ChEBI:] synonym: "InChI=1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2" RELATED InChI [ChEBI:] synonym: "InChIKey=VHJLVAABSRFDPM-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "OC(CS)C(O)CS" RELATED SMILES [ChEBI:] synonym: "rac-Dithiothreitol" RELATED [ChemIDplus:] synonym: "rel-(2R,3R)-1,4-disulfanylbutane-2,3-diol" EXACT IUPAC_NAME [IUPAC:] synonym: "threo-1,4-Dimercapto-2,3-butanediol" RELATED [KEGG COMPOUND:] xref: Beilstein:8144556 "Beilstein Registry Number" xref: ChemIDplus:3483-12-3 "CAS Registry Number" xref: CiteXplore:16901854 "PubMed citation" xref: CiteXplore:18022205 "PubMed citation" xref: CiteXplore:23673948 "PubMed citation" xref: CiteXplore:24124079 "PubMed citation" xref: CiteXplore:7592847 "PubMed citation" xref: DrugBank:DB04447 "DrugBank" xref: KEGG COMPOUND:3483-12-3 "CAS Registry Number" xref: KEGG COMPOUND:C00265 "KEGG COMPOUND" xref: NIST Chemistry WebBook:3483-12-3 "CAS Registry Number" is_a: CHEBI:23853 ! dithiol is_a: CHEBI:25189 ! 1,4-dimercaptobutane-2,3-diol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:18335 name: pyridoxamine 5'-phosphate namespace: chebi_ontology alt_id: CHEBI:14979 alt_id: CHEBI:14980 alt_id: CHEBI:26427 alt_id: CHEBI:45037 alt_id: CHEBI:8670 def: "A vitamin B6 phosphate that is the phosphoric ester derivative of pyridoxamine." [] synonym: "4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE" RELATED [PDBeChem:] synonym: "[4-(aminomethyl)-5-hydroxy-6-methylpyridin-3-yl]methyl dihydrogen phosphate" EXACT IUPAC_NAME [IUPAC:] synonym: "C8H13N2O5P" RELATED FORMULA [KEGG COMPOUND:] synonym: "Cc1ncc(COP(O)(O)=O)c(CN)c1O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C8H13N2O5P/c1-5-8(11)7(2-9)6(3-10-5)4-15-16(12,13)14/h3,11H,2,4,9H2,1H3,(H2,12,13,14)" RELATED InChI [ChEBI:] synonym: "InChIKey=ZMJGSOSNSPKHNH-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "pyridoxamine 5'-(dihydrogen phosphate)" RELATED [ChEBI:] synonym: "Pyridoxamine 5'-phosphate" EXACT [KEGG COMPOUND:] synonym: "Pyridoxamine 5-phosphate" RELATED [KEGG COMPOUND:] synonym: "Pyridoxamine phosphate" RELATED [KEGG COMPOUND:] xref: Beilstein:233653 "Beilstein Registry Number" xref: ChemIDplus:529-96-4 "CAS Registry Number" xref: CiteXplore:1783639 "PubMed citation" xref: CiteXplore:18491919 "PubMed citation" xref: CiteXplore:22445054 "PubMed citation" xref: COMe:MOL000123 "COMe" xref: HMDB:HMDB01555 "HMDB" xref: KEGG COMPOUND:529-96-4 "CAS Registry Number" xref: KEGG COMPOUND:C00647 "KEGG COMPOUND" xref: KNApSAcK:C00007506 "KNApSAcK" xref: PDBeChem:PMP "PDBeChem" xref: Reaxys:233653 "Reaxys Registry Number" is_a: CHEBI:25340 ! methylpyridines is_a: CHEBI:36970 ! vitamin B6 phosphate is_a: CHEBI:38182 ! monohydroxypyridine is_a: CHEBI:38198 ! aminoalkylpyridine property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:18375 name: nucleoside 3',5'-cyclic phosphate namespace: chebi_ontology alt_id: CHEBI:1331 alt_id: CHEBI:14672 alt_id: CHEBI:19833 def: "A ribosyl or deoxyribosyl derivative of a pyrimidine or purine base in which C-3 and C-5 of the ribose ring are engaged in formation of a cyclic mono-, di-, tri- or tetra-phosphate." [] synonym: "3',5'-Cyclic nucleotide" RELATED [KEGG COMPOUND:] synonym: "3',5'-cyclic nucleotides" RELATED [ChEBI:] synonym: "C5H7O5PR2" RELATED FORMULA [ChEBI:] synonym: "Nucleoside 3',5'-cyclic phosphate" EXACT [KEGG COMPOUND:] synonym: "nucleoside 3',5'-cyclic phosphate" EXACT [ChEBI:] synonym: "nucleoside 3',5'-cyclic phosphates" RELATED [ChEBI:] synonym: "OP1(=O)OC[C@H]2O[C@@H]([*])[C@H]([*])[C@@H]2O1" RELATED SMILES [ChEBI:] xref: KEGG COMPOUND:C04212 "KEGG COMPOUND" is_a: CHEBI:23447 ! cyclic nucleotide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:18379 name: nitrile namespace: chebi_ontology alt_id: CHEBI:13212 alt_id: CHEBI:13426 alt_id: CHEBI:13660 alt_id: CHEBI:25547 alt_id: CHEBI:7584 def: "A compound having the structure RC#N; thus a C-substituted derivative of hydrocyanic acid, HC#N. In systematic nomenclature, the suffix nitrile denotes the triply bound #N atom, not the carbon atom attached to it." [] synonym: "[*]C#N" RELATED SMILES [ChEBI:] synonym: "a nitrile" RELATED [UniProt:] synonym: "CNR" RELATED FORMULA [ChEBI:] synonym: "Nitril" RELATED [ChEBI:] synonym: "Nitrile" EXACT [KEGG COMPOUND:] synonym: "nitrile" EXACT [IUPAC:] synonym: "nitriles" EXACT IUPAC_NAME [IUPAC:] synonym: "nitrilos" RELATED [IUPAC:] synonym: "R-CN" RELATED [KEGG COMPOUND:] xref: KEGG COMPOUND:C00726 "KEGG COMPOUND" is_a: CHEBI:23424 ! cyanides property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:18420 name: magnesium(2+) namespace: chebi_ontology alt_id: CHEBI:13379 alt_id: CHEBI:25112 alt_id: CHEBI:49736 alt_id: CHEBI:6635 def: "A magnesium cation that has formula Mg." [] synonym: "[Mg++]" RELATED SMILES [ChEBI:] synonym: "InChI=1S/Mg/q+2" RELATED InChI [ChEBI:] synonym: "InChIKey=JLVVSXFLKOJNIY-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "magnesium" RELATED [PDBeChem:] synonym: "magnesium cation" EXACT IUPAC_NAME [IUPAC:] synonym: "MAGNESIUM ION" RELATED [PDBeChem:] synonym: "magnesium(2+)" EXACT IUPAC_NAME [IUPAC:] synonym: "magnesium(2+) ion" EXACT IUPAC_NAME [IUPAC:] synonym: "magnesium(II) cation" EXACT IUPAC_NAME [IUPAC:] synonym: "magnesium, doubly charged positive ion" RELATED [NIST Chemistry WebBook:] synonym: "magnesium, ion (Mg(2+))" RELATED [ChemIDplus:] synonym: "Mg" RELATED FORMULA [KEGG COMPOUND:] synonym: "Mg(2+)" RELATED [UniProt:] synonym: "Mg(2+)" RELATED [IUPAC:] synonym: "Mg2+" RELATED [KEGG COMPOUND:] xref: ChemIDplus:22537-22-0 "CAS Registry Number" xref: Gmelin:6857 "Gmelin Registry Number" xref: KEGG COMPOUND:C00305 "KEGG COMPOUND" xref: NIST Chemistry WebBook:22537-22-0 "CAS Registry Number" xref: PDBeChem:MG "PDBeChem" is_a: CHEBI:30412 ! monoatomic dication is_a: CHEBI:39127 ! magnesium cation is_a: CHEBI:60240 ! divalent metal cation property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:18946 name: delta-lactone namespace: chebi_ontology def: "A lactone having a six-membered lactone ring." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "1,5-lactone" RELATED [ChEBI:] synonym: "1,5-lactones" RELATED [ChEBI:] synonym: "delta-lactona" RELATED [ChEBI:] synonym: "delta-lactonas" RELATED [ChEBI:] synonym: "delta-lactone" EXACT [ChEBI:] synonym: "delta-lactones" RELATED [ChEBI:] is_a: CHEBI:25000 ! lactone property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:19237 name: 2'-deoxyadenosine 5'-phosphate namespace: chebi_ontology synonym: "2'-deoxyadenosine 5'-phosphate" EXACT [ChEBI:] synonym: "2'-deoxyadenosine 5'-phosphates" RELATED [ChEBI:] is_a: CHEBI:19239 ! 2'-deoxyadenosine phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:19239 name: 2'-deoxyadenosine phosphate namespace: chebi_ontology synonym: "2'-deoxyadenosine phosphates" RELATED [ChEBI:] is_a: CHEBI:23612 ! deoxyadenosine phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:19260 name: 2'-deoxyribonucleotide namespace: chebi_ontology synonym: "2'-deoxyribonucleotides" RELATED [ChEBI:] is_a: CHEBI:19569 ! 2-deoxyribose phosphate is_a: CHEBI:4431 ! deoxyribonucleotide is_a: CHEBI:47018 ! monohydroxytetrahydrofuran property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:19569 name: 2-deoxyribose phosphate namespace: chebi_ontology alt_id: CHEBI:60749 def: "A deoxyaldopentose phosphate in which the deoxyaldopentose is 2-deoxyribose." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "2-deoxyribose phosphate" EXACT [SUBMITTER:] synonym: "2-deoxyribose phosphates" RELATED [ChEBI:] synonym: "deoxyribose phosphate" RELATED [ChEBI:] is_a: CHEBI:23634 ! deoxyaldopentose phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:19834 name: 3',5'-cyclic purine nucleotide namespace: chebi_ontology synonym: "3',5'-cyclic purine nucleotides" RELATED [ChEBI:] is_a: CHEBI:18375 ! nucleoside 3',5'-cyclic phosphate is_a: CHEBI:36982 ! cyclic purine nucleotide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:2038 name: 5-azacytidine namespace: chebi_ontology def: "A N-glycosyl-1,3,5-triazine that is 4-amino-1,3,5-triazin-2(1H)-one substituted by a beta-D-ribofuranosyl residue via a N-glycosidic linkage." [] synonym: "4-amino-1-beta-D-ribofuranosyl-1,3,5-triazin-2(1H)-one" EXACT IUPAC_NAME [IUPAC:] synonym: "4-Amino-1-beta-D-ribofuranosyl-s-triazin-2(1H)-one" RELATED [ChemIDplus:] synonym: "5-Azacytidine" EXACT [KEGG COMPOUND:] synonym: "5-azacytidine" EXACT IUPAC_NAME [IUPAC:] synonym: "azacitidina" RELATED INN [ChemIDplus:] synonym: "Azacitidine" RELATED [KEGG COMPOUND:] synonym: "azacitidinum" RELATED INN [ChemIDplus:] synonym: "C8H12N4O5" RELATED FORMULA [KEGG COMPOUND:] synonym: "InChI=1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=NMUSYJAQQFHJEW-KVTDHHQDSA-N" RELATED InChIKey [ChEBI:] synonym: "Nc1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1" RELATED SMILES [ChEBI:] xref: ChemIDplus:320-67-2 "CAS Registry Number" xref: CiteXplore:11841042 "PubMed citation" xref: CiteXplore:17611569 "PubMed citation" xref: DrugBank:DB00928 "DrugBank" xref: HMDB:HMDB15063 "HMDB" xref: KEGG COMPOUND:320-67-2 "CAS Registry Number" xref: KEGG COMPOUND:C11262 "KEGG COMPOUND" xref: KEGG DRUG:D03021 "KEGG DRUG" xref: Patent:KR20140069225 "Patent" xref: Patent:US2015038444 "Patent" xref: Reaxys:620461 "Reaxys Registry Number" xref: Wikipedia:Azacitidine "Wikipedia" is_a: CHEBI:48009 ! N-glycosyl-1,3,5-triazine is_a: CHEBI:60783 ! nucleoside analogue property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:20706 name: 6-aminopurines namespace: chebi_ontology def: "Any compound having 6-aminopurine (adenine) as part of its structure." [] synonym: "6-aminopurines" EXACT [ChEBI:] xref: CiteXplore:1646334 "PubMed citation" xref: CiteXplore:18524423 "PubMed citation" xref: CiteXplore:7342604 "PubMed citation" is_a: CHEBI:22527 ! aminopurine property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:20857 name: C-glycosyl compound namespace: chebi_ontology def: "A glycosyl compound arising formally from the elimination of water from a glycosidic hydroxy group and an H atom bound to a carbon atom, thus creating a C-C bond." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "C-glycoside" RELATED [ChEBI:] synonym: "C-glycosides" RELATED [ChEBI:] synonym: "C-glycosyl compounds" RELATED [ChEBI:] is_a: CHEBI:63161 ! glycosyl compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:21080 name: ribose diphosphate namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "D-ribose 1-diphosphates" RELATED [ChEBI:] synonym: "ribose diphosphate" EXACT [ChEBI:] synonym: "ribose diphosphates" RELATED [ChEBI:] xref: ChEBI:C06248 "KEGG COMPOUND" is_a: CHEBI:26562 ! ribose phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:21731 name: N-glycosyl compound namespace: chebi_ontology def: "A glycosyl compound arising formally from the elimination of water from a glycosidic hydroxy group and an H atom bound to a nitrogen atom, thus creating a C-N bond." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "glycosylamine" EXACT IUPAC_NAME [IUPAC:] synonym: "glycosylamines" RELATED [IUPAC:] synonym: "N-glycoside" RELATED [ChEBI:] synonym: "N-glycosides" RELATED [ChEBI:] synonym: "N-glycosyl compounds" RELATED [ChEBI:] is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:63161 ! glycosyl compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:21752 name: N-methyl-L-alpha-amino acid namespace: chebi_ontology alt_id: CHEBI:7310 def: "An non-proteinogenic L-alpha-amino acid in which the amino group bears one or more methyl groups." [] synonym: "C3H6NO2R" RELATED FORMULA [KEGG COMPOUND:] synonym: "CN[C@@H]([*])C(O)=O" RELATED SMILES [ChEBI:] synonym: "N-methyl-L-alpha-amino acids" RELATED [ChEBI:] synonym: "N-Methyl-L-amino acid" RELATED [KEGG COMPOUND:] synonym: "N-methyl-L-amino acid" RELATED [ChEBI:] synonym: "N-methyl-L-amino acids" RELATED [ChEBI:] xref: KEGG COMPOUND:C03148 "KEGG COMPOUND" is_a: CHEBI:21760 ! N-methyl-amino acid is_a: CHEBI:83822 ! non-proteinogenic L-alpha-amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:21759 name: N-methyl-N'-nitro-N-nitrosoguanidine namespace: chebi_ontology alt_id: CHEBI:34872 def: "An N-nitroguanidine compound having nitroso and methyl substituents at the N'-position" [] synonym: "1-Methyl-1-nitroso-3-nitroguanidine" RELATED [ChemIDplus:] synonym: "1-Methyl-3-nitro-1-nitrosoguanidine" RELATED [KEGG COMPOUND:] synonym: "1-methyl-3-nitro-1-nitrosoguanidine" EXACT IUPAC_NAME [IUPAC:] synonym: "1-Nitroso-3-nitro-1-methylguanidine" RELATED [ChemIDplus:] synonym: "C2H5N5O3" RELATED FORMULA [ChEBI:] synonym: "CN(N=O)C(=N)N[N+]([O-])=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C2H5N5O3/c1-6(5-8)2(3)4-7(9)10/h1H3,(H2,3,4)" RELATED InChI [ChEBI:] synonym: "InChIKey=VZUNGTLZRAYYDE-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "Methylnitronitrosoguanidine" RELATED [KEGG COMPOUND:] synonym: "MNG" RELATED [ChemIDplus:] synonym: "MNNG" RELATED [KEGG COMPOUND:] synonym: "MNNG" RELATED [ChemIDplus:] synonym: "N'-Nitro-N-nitroso-N-methylguanidine" RELATED [ChemIDplus:] synonym: "N-Methyl-N',2-dioxohydrazinecarboximidohydrazide 2-oxide" RELATED [NIST Chemistry WebBook:] synonym: "N-Methyl-N'-nitro-N-nitrosoguanidine" EXACT [KEGG COMPOUND:] synonym: "N-Methyl-N-nitroso-N'-nitroguanidine" RELATED [ChEBI:] synonym: "N-Methyl-N-nitroso-N'-nitroguanidine" RELATED [ChemIDplus:] synonym: "N-Methyl-N-nitrosonitroguanidin" RELATED [ChEBI:] synonym: "N-Nitroso-N-methyl-N'-nitroguanidine" RELATED [ChemIDplus:] xref: Beilstein:1779490 "Beilstein Registry Number" xref: ChemIDplus:70-25-7 "CAS Registry Number" xref: KEGG COMPOUND:70-25-7 "CAS Registry Number" xref: KEGG COMPOUND:C14592 "KEGG COMPOUND" xref: NIST Chemistry WebBook:70-25-7 "CAS Registry Number" is_a: CHEBI:35800 ! nitroso compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:21760 name: N-methyl-amino acid namespace: chebi_ontology def: "An amino acid derivative in which at least one of the hydrogens of the amino group has been replaced by a methyl group." [] synonym: "N-methyl-amino acids" RELATED [ChEBI:] is_a: CHEBI:83821 ! amino acid derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:21911 name: N(alpha)-methyl-L-histidines namespace: chebi_ontology def: "A N-methyl-L-alpha-amino acid that is L-histidine in which at least one of the amino hydrogens has been replaced by a methyl group." [] is_a: CHEBI:21752 ! N-methyl-L-alpha-amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22063 name: S-oxide namespace: chebi_ontology synonym: "S-oxides" RELATED [ChEBI:] is_a: CHEBI:25741 ! oxide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22260 name: adenosines namespace: chebi_ontology synonym: "adenosines" EXACT [ChEBI:] is_a: CHEBI:26399 ! purine ribonucleoside property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22299 name: aldonate namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "aldonate" EXACT [ChEBI:] synonym: "aldonates" RELATED [ChEBI:] is_a: CHEBI:33721 ! carbohydrate acid anion is_a: CHEBI:35757 ! monocarboxylic acid anion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22315 name: alkaloid namespace: chebi_ontology def: "Any of the naturally occurring, basic nitrogen compounds (mostly heterocyclic) occurring mostly in the plant kingdom, but also found in bacteria, fungi, and animals. By extension, certain neutral compounds biogenetically related to basic alkaloids are also classed as alkaloids. Amino acids, peptides, proteins, nucleotides, nucleic acids, amino sugars and antibiotics are not normally regarded as alkaloids. Compounds in which the nitrogen is exocyclic (dopamine, mescaline, serotonin, etc.) are usually classed as amines rather than alkaloids." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "alcaloide" RELATED [ChEBI:] synonym: "alcaloides" RELATED [ChEBI:] synonym: "Alkaloid" EXACT [ChEBI:] synonym: "Alkaloide" RELATED [ChEBI:] synonym: "alkaloids" EXACT IUPAC_NAME [IUPAC:] xref: Wikipedia:Alkaloid "Wikipedia" is_a: CHEBI:35352 ! organonitrogen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22331 name: alkylamines namespace: chebi_ontology def: "Any amine formally derived from ammonia by replacing one, two or three hydrogen atoms by alkyl groups." [] synonym: "alkylamines" EXACT [ChEBI:] xref: ChEBI:C01664 "KEGG COMPOUND" is_a: CHEBI:32952 ! amine property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22385 name: alpha-D-glucan namespace: chebi_ontology alt_id: CHEBI:10241 synonym: "(C6H10O5)n" RELATED FORMULA [KEGG COMPOUND:] synonym: "alpha-D-Glucan" EXACT [KEGG COMPOUND:] synonym: "alpha-D-glucans" RELATED [ChEBI:] xref: KEGG COMPOUND:C00912 "KEGG COMPOUND" is_a: CHEBI:37163 ! glucan property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22475 name: amino acid amide namespace: chebi_ontology def: "An amide of an amino acid formed formally by conversion of the carboxy group to a carboxamido group." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "amino acid amides" RELATED [ChEBI:] is_a: CHEBI:37622 ! carboxamide is_a: CHEBI:83821 ! amino acid derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22478 name: amino alcohol namespace: chebi_ontology def: "An alcohol containing an amino functional group in addition to the alcohol-defining hydroxy group." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "amino alcohols" RELATED [ChEBI:] synonym: "aminoalcohol" RELATED [ChEBI:] synonym: "aminoalcohols" RELATED [ChEBI:] is_a: CHEBI:30879 ! alcohol is_a: CHEBI:50047 ! organic amino compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22479 name: amino cyclitol glycoside namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "amino cyclitol glycoside" EXACT [ChEBI:] synonym: "amino cyclitol glycosides" RELATED [ChEBI:] synonym: "amino cyclitols" RELATED [ChEBI:] synonym: "aminoglycosides" RELATED [ChEBI:] is_a: CHEBI:23451 ! cyclitol is_a: CHEBI:24400 ! glycoside property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22483 name: amino oligosaccharide namespace: chebi_ontology synonym: "amino oligosaccharides" RELATED [ChEBI:] synonym: "amino-oligosaccharides" RELATED [ChEBI:] is_a: CHEBI:63563 ! oligosaccharide derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22485 name: glucosamine oligosaccharide namespace: chebi_ontology synonym: "amino-oligosaccharides, glucosaminyl" RELATED [ChEBI:] synonym: "glucosamine oligosaccharides" RELATED [ChEBI:] is_a: CHEBI:22483 ! amino oligosaccharide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22507 name: aminoglycoside antibiotic namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "aminoglycoside antibiotics" RELATED [ChEBI:] is_a: CHEBI:23007 ! carbohydrate-containing antibiotic is_a: CHEBI:47779 ! aminoglycoside property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22527 name: aminopurine namespace: chebi_ontology def: "Any purine having at least one amino substituent." [] synonym: "aminopurines" RELATED [ChEBI:] is_a: CHEBI:26401 ! purines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22563 name: anion namespace: chebi_ontology def: "A monoatomic or polyatomic species having one or more elementary charges of the electron." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "Anion" EXACT [ChEBI:] synonym: "anion" EXACT [ChEBI:] synonym: "anion" EXACT IUPAC_NAME [IUPAC:] synonym: "Anionen" RELATED [ChEBI:] synonym: "aniones" RELATED [ChEBI:] synonym: "anions" RELATED [IUPAC:] is_a: CHEBI:24870 ! ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22584 name: antimycin A namespace: chebi_ontology def: "A nine-membered bis-lactone having methyl substituents at the 2- and 6-positions, an n-hexyl substituent at the 8-position, an acyloxy substituent at the 7-position and an aroylamido substituent at the 3-position. It is produced by Streptomyces bacteria and has found commercial use as a fish poison." [] synonym: "(2R,3S,6S,7R,8R)-3-[(3-formamido-2-hydroxybenzoyl)amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl 3-methylbutanoate" EXACT IUPAC_NAME [IUPAC:] synonym: "[H]C(=O)Nc1cccc(C(=O)N[C@H]2[C@@H](C)OC(=O)[C@H](CCCCCC)[C@@H](OC(=O)CC(C)C)[C@H](C)OC2=O)c1O" RELATED SMILES [ChEBI:] synonym: "Antimycin A1" RELATED [KEGG COMPOUND:] synonym: "antimycin A1b" RELATED [ChEBI:] synonym: "Antipiricullin" RELATED [ChemIDplus:] synonym: "C28H40N2O9" RELATED FORMULA [ChEBI:] synonym: "Fintrol" RELATED [ChemIDplus:] synonym: "InChI=1S/C28H40N2O9/c1-6-7-8-9-11-20-25(39-22(32)14-16(2)3)18(5)38-28(36)23(17(4)37-27(20)35)30-26(34)19-12-10-13-21(24(19)33)29-15-31/h10,12-13,15-18,20,23,25,33H,6-9,11,14H2,1-5H3,(H,29,31)(H,30,34)/t17-,18+,20-,23+,25+/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=UIFFUZWRFRDZJC-SBOOETFBSA-N" RELATED InChIKey [ChEBI:] synonym: "Virosin" RELATED [ChemIDplus:] xref: Beilstein:72665 "Beilstein Registry Number" xref: ChEBI:116095-18-2 "CAS Registry Number" xref: ChemIDplus:1397-94-0 "CAS Registry Number" xref: ChemIDplus:642-15-9 "CAS Registry Number" xref: KEGG COMPOUND:642-15-9 "CAS Registry Number" xref: KEGG COMPOUND:C11339 "KEGG COMPOUND" is_a: CHEBI:22702 ! benzamides is_a: CHEBI:24079 ! formamides is_a: CHEBI:25000 ! lactone is_a: CHEBI:33853 ! phenols property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22586 name: antioxidant namespace: chebi_ontology def: "A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. In European countries, E-numbers for permitted antioxidant food additives are from E 300 to E 324." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "antioxidants" RELATED [ChEBI:] synonym: "antioxydant" RELATED [ChEBI:] synonym: "antoxidant" RELATED [ChEBI:] is_a: CHEBI:51086 ! chemical role property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22629 name: arsenate ion namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "arsenate" RELATED [ChEBI:] synonym: "arsenate anions" RELATED [ChEBI:] synonym: "arsenate ions" RELATED [ChEBI:] is_a: CHEBI:35776 ! arsenic oxoanion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22632 name: arsenic molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "arsenic compounds" RELATED [ChEBI:] synonym: "arsenic molecular entities" RELATED [ChEBI:] synonym: "arsenic molecular entity" EXACT [ChEBI:] is_a: CHEBI:33302 ! pnictogen molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22645 name: arenecarboxamide namespace: chebi_ontology def: "A monocarboxylic acid amide in which the amide linkage is bonded directly to an arene ring system." [] synonym: "arenecarboxamides" RELATED [ChEBI:] is_a: CHEBI:29347 ! monocarboxylic acid amide is_a: CHEBI:62733 ! aromatic amide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22653 name: asparagine namespace: chebi_ontology def: "An alpha-amino acid in which one of the hydrogens attached to the alpha-carbon of glycine is substituted by a 2-amino-2-oxoethyl group." [] synonym: "2,4-diamino-4-oxobutanoic acid" RELATED [IUPAC:] synonym: "2-amino-3-carbamoylpropanoic acid" RELATED [JCBN:] synonym: "ASN" RELATED [ChEBI:] synonym: "Asn" RELATED [ChEBI:] synonym: "Asparagin" RELATED [ChEBI:] synonym: "asparagina" RELATED [ChEBI:] synonym: "asparagine" EXACT IUPAC_NAME [IUPAC:] synonym: "C4H8N2O3" RELATED FORMULA [ChEBI:] synonym: "DL-Asparagine" RELATED [KEGG COMPOUND:] synonym: "Hasp" RELATED [IUPAC:] synonym: "InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)" RELATED InChI [ChEBI:] synonym: "InChIKey=DCXYFEDJOCDNAF-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "N" RELATED [ChEBI:] synonym: "NC(CC(N)=O)C(O)=O" RELATED SMILES [ChEBI:] xref: Beilstein:1723525 "Beilstein Registry Number" xref: ChemIDplus:3130-87-8 "CAS Registry Number" xref: CiteXplore:22264337 "PubMed citation" xref: CiteXplore:22770225 "PubMed citation" xref: Gmelin:279043 "Gmelin Registry Number" xref: KEGG COMPOUND:C16438 "KEGG COMPOUND" xref: Reaxys:1723525 "Reaxys Registry Number" xref: Wikipedia:Asparagine "Wikipedia" is_a: CHEBI:33704 ! alpha-amino acid is_a: CHEBI:35735 ! dicarboxylic acid monoamide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22658 name: aspartate family amino acid namespace: chebi_ontology def: "An L-alpha-amino acid which is L-aspartic acid or any of the essential amino acids biosynthesised from it (asparagine, lysine, methionine, threonine and isoleucine). A closed class." [] synonym: "aspartate family amino acids" RELATED [ChEBI:] synonym: "aspartic acid family amino acid" RELATED [ChEBI:] synonym: "aspartic acid family amino acids" RELATED [ChEBI:] synonym: "oxaloacetate family amino acid" RELATED [ChEBI:] synonym: "oxaloacetate family amino acids" RELATED [ChEBI:] synonym: "oxaloacetate/aspartate family amino acid" RELATED [ChEBI:] synonym: "oxaloacetate/aspartate family amino acids" RELATED [ChEBI:] xref: CiteXplore:4386082 "PubMed citation" xref: CiteXplore:4394351 "PubMed citation" xref: CiteXplore:4721772 "PubMed citation" xref: CiteXplore:5016260 "PubMed citation" xref: CiteXplore:5074276 "PubMed citation" is_a: CHEBI:15705 ! L-alpha-amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22689 name: bafilomycin A1 namespace: chebi_ontology def: "The most used of the bafilomycins, a family of toxic macrolide antibiotics derived from Streptomyces griseus." [] synonym: "(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-{(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-dihydroxy-6-isopropyl-5-methyltetrahydro-2H-pyran-2-yl]-3-hydroxypentan-2-yl}-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one" EXACT IUPAC_NAME [IUPAC:] synonym: "bafilomycin A1" EXACT [ChEBI:] synonym: "C35H58O9" RELATED FORMULA [ChEBI:] synonym: "CO[C@H]1\\C=C\\C=C(C)\\C[C@H](C)[C@H](O)[C@H](C)\\C=C(C)\\C=C(OC)\\C(=O)O[C@@H]1[C@@H](C)[C@@H](O)[C@H](C)[C@@]1(O)C[C@@H](O)[C@H](C)[C@H](O1)C(C)C" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12+,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33+,35+/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=XDHNQDDQEHDUTM-JQWOJBOSSA-N" RELATED InChIKey [ChEBI:] xref: Beilstein:3640011 "Beilstein Registry Number" xref: Beilstein:4730699 "Beilstein Registry Number" xref: Beilstein:4730700 "Beilstein Registry Number" xref: ChemIDplus:88899-55-2 "CAS Registry Number" xref: CiteXplore:10519916 "PubMed citation" xref: CiteXplore:11533151 "PubMed citation" xref: CiteXplore:17917797 "PubMed citation" xref: CiteXplore:19067440 "PubMed citation" xref: CiteXplore:19289106 "PubMed citation" xref: CiteXplore:20820851 "PubMed citation" xref: CiteXplore:22344969 "PubMed citation" xref: CiteXplore:22943412 "PubMed citation" xref: CiteXplore:23038011 "PubMed citation" xref: CiteXplore:23480984 "PubMed citation" xref: CiteXplore:7817803 "PubMed citation" xref: CiteXplore:8446034 "PubMed citation" xref: Reaxys:4730700 "Reaxys Registry Number" is_a: CHEBI:25105 ! macrolide antibiotic is_a: CHEBI:46942 ! oxanes is_a: CHEBI:59780 ! cyclic hemiketal property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22702 name: benzamides namespace: chebi_ontology synonym: "benzamides" EXACT [ChEBI:] is_a: CHEBI:22645 ! arenecarboxamide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22712 name: benzenes namespace: chebi_ontology def: "Any benzenoid aromatic compound consisting of the benzene skeleton and its substituted derivatives." [] synonym: "benzenes" EXACT [ChEBI:] is_a: CHEBI:33836 ! benzenoid aromatic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22715 name: benzimidazoles namespace: chebi_ontology def: "An organic heterocyclic compound containing a benzene ring fused to an imidazole ring." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "benzimidazoles" EXACT [ChEBI:] is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22727 name: benzopyran namespace: chebi_ontology synonym: "benzopyrans" RELATED [ChEBI:] xref: Wikipedia:Benzopyran "Wikipedia" is_a: CHEBI:38104 ! oxacycle is_a: CHEBI:38166 ! organic heteropolycyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22728 name: benzopyrrole namespace: chebi_ontology synonym: "benzopyrroles" RELATED [ChEBI:] is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound is_a: CHEBI:38180 ! polycyclic heteroarene property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22729 name: benzoquinones namespace: chebi_ontology def: "A quinone that is a cyclohexadiene which is substituted by two oxo groups." [] synonym: "benzoquinones" EXACT [ChEBI:] is_a: CHEBI:36141 ! quinone property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22798 name: beta-D-glucoside namespace: chebi_ontology alt_id: CHEBI:10400 synonym: "." RELATED FORMULA [ChEBI:] synonym: "beta-D-Glucoside" EXACT [KEGG COMPOUND:] synonym: "beta-D-glucoside" EXACT [ChEBI:] synonym: "beta-D-glucosides" RELATED [ChEBI:] synonym: "C6H11O6R" RELATED FORMULA [KEGG COMPOUND:] synonym: "OC[C@H]1O[C@@H](O[*])[C@H](O)[C@@H](O)[C@@H]1O" RELATED SMILES [ChEBI:] xref: KEGG COMPOUND:C00963 "KEGG COMPOUND" is_a: CHEBI:35436 ! D-glucoside is_a: CHEBI:60980 ! beta-glucoside property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22860 name: amino-acid betaine namespace: chebi_ontology def: "Any amino acid-derived zwitterion - such as glycine betaine (N,N,N-trimethylammonioacetate) - in which the ammonium nitrogen carries three methyl substituents." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "amino acid betaines" RELATED [ChEBI:] synonym: "amino-acid betaines" RELATED [ChEBI:] synonym: "betaines" RELATED [ChEBI:] is_a: CHEBI:35284 ! ammonium betaine property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22907 name: bleomycin namespace: chebi_ontology alt_id: CHEBI:584977 def: "A glycopeptide antibiotic produced by the bacterium Streptomyces verticillus. The term, 'bleomycin' refers to a family of structurally related compounds. When used as an anti-cancer agent, the chemotherapeutical forms are primarily bleomycin A2 and B2." [] synonym: "bleomycins" RELATED [ChEBI:] xref: ChEBI:C06854 "KEGG COMPOUND" xref: DrugBank:DB00290 "DrugBank" xref: Wikipedia:Bleomycin "Wikipedia" is_a: CHEBI:23089 ! chelate-forming peptide is_a: CHEBI:24395 ! glycopeptide antibiotic property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22918 name: branched-chain amino acid namespace: chebi_ontology synonym: "branched chain amino acids" RELATED [ChEBI:] is_a: CHEBI:33709 ! amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22925 name: bromide salt namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "bromide salts" RELATED [ChEBI:] synonym: "bromides" RELATED [ChEBI:] is_a: CHEBI:22928 ! bromine molecular entity is_a: CHEBI:33958 ! halide salt property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22928 name: bromine molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "bromine compounds" RELATED [ChEBI:] synonym: "bromine molecular entities" RELATED [ChEBI:] synonym: "bromine molecular entity" EXACT [ChEBI:] is_a: CHEBI:24471 ! halogen molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22944 name: butanediols namespace: chebi_ontology def: "A diol that is a butanediol or a derivative of a butanediol." [] synonym: "butanediols" EXACT [ChEBI:] is_a: CHEBI:23824 ! diol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22978 name: cadmium molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "cadmium compounds" RELATED [ChEBI:] synonym: "cadmium molecular entities" RELATED [ChEBI:] is_a: CHEBI:33673 ! zinc group molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:22985 name: calcium molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "calcium compounds" RELATED [ChEBI:] synonym: "calcium molecular entities" RELATED [ChEBI:] synonym: "calcium molecular entity" EXACT [ChEBI:] is_a: CHEBI:33299 ! alkaline earth molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23003 name: carbamate ester namespace: chebi_ontology def: "Any ester of carbamic acid or its N-substituted derivatives." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "carbamate esters" RELATED [ChEBI:] synonym: "carbamates" RELATED [ChEBI:] xref: Wikipedia:Carbamate "Wikipedia" is_a: CHEBI:33308 ! carboxylic ester property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23007 name: carbohydrate-containing antibiotic namespace: chebi_ontology def: "Any carbohydrate derivative that exhibits antibiotic activity." [] synonym: "carbohydrate-containing antibiotics" RELATED [ChEBI:] is_a: CHEBI:63299 ! carbohydrate derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23089 name: chelate-forming peptide namespace: chebi_ontology synonym: "chelate-forming peptides" RELATED [ChEBI:] is_a: CHEBI:25903 ! peptide antibiotic property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23114 name: chloride salt namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "chloride salts" RELATED [ChEBI:] synonym: "chlorides" RELATED [ChEBI:] is_a: CHEBI:23117 ! chlorine molecular entity is_a: CHEBI:33958 ! halide salt property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23117 name: chlorine molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "chlorine compounds" RELATED [ChEBI:] synonym: "chlorine molecular entities" RELATED [ChEBI:] is_a: CHEBI:24471 ! halogen molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23132 name: chlorobenzenes namespace: chebi_ontology def: "Any organochlorine compound containing a benzene ring which is substituted by one or more chlorines." [] synonym: "." RELATED FORMULA [ChEBI:] is_a: CHEBI:22712 ! benzenes is_a: CHEBI:36683 ! organochlorine compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23217 name: cholines namespace: chebi_ontology synonym: "cholines" EXACT [ChEBI:] is_a: CHEBI:23981 ! ethanolamines is_a: CHEBI:35267 ! quaternary ammonium ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23232 name: chromenes namespace: chebi_ontology synonym: "chromenes" EXACT [ChEBI:] is_a: CHEBI:38443 ! 1-benzopyran property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23237 name: chromium molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "chromium compounds" RELATED [ChEBI:] synonym: "chromium molecular entities" RELATED [ChEBI:] synonym: "chromium molecular entity" EXACT [ChEBI:] is_a: CHEBI:33741 ! chromium group molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23239 name: chromopeptide namespace: chebi_ontology synonym: "chromopeptides" RELATED [ChEBI:] is_a: CHEBI:25903 ! peptide antibiotic property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23324 name: citrullines namespace: chebi_ontology synonym: "citrullines" EXACT [ChEBI:] is_a: CHEBI:83925 ! non-proteinogenic alpha-amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23336 name: cobalt cation namespace: chebi_ontology synonym: "Co" RELATED FORMULA [ChEBI:] synonym: "cobalt cation" EXACT [UniProt:] synonym: "cobalt cation" EXACT IUPAC_NAME [IUPAC:] synonym: "cobalt cations" RELATED [ChEBI:] is_a: CHEBI:33515 ! transition element cation property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23367 name: molecular entity namespace: chebi_ontology def: "Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "entidad molecular" RELATED [IUPAC:] synonym: "entidades moleculares" RELATED [IUPAC:] synonym: "entite moleculaire" RELATED [IUPAC:] synonym: "molecular entities" RELATED [IUPAC:] synonym: "molecular entity" EXACT IUPAC_NAME [IUPAC:] synonym: "molekulare Entitaet" RELATED [ChEBI:] is_a: CHEBI:24431 ! chemical entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23377 name: copper molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "copper compounds" RELATED [ChEBI:] synonym: "copper molecular entities" RELATED [ChEBI:] synonym: "copper molecular entity" EXACT [ChEBI:] is_a: CHEBI:33745 ! copper group molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23378 name: copper cation namespace: chebi_ontology synonym: "copper cation" EXACT IUPAC_NAME [IUPAC:] synonym: "copper cations" RELATED [ChEBI:] synonym: "Cu" RELATED FORMULA [ChEBI:] synonym: "Cu cation" RELATED [UniProt:] is_a: CHEBI:33515 ! transition element cation is_a: CHEBI:37404 ! elemental copper property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23424 name: cyanides namespace: chebi_ontology def: "Salts and C-organyl derivatives of hydrogen cyanide, HC#N." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "cyanides" EXACT IUPAC_NAME [IUPAC:] is_a: CHEBI:35352 ! organonitrogen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23443 name: cyclic amide namespace: chebi_ontology alt_id: CHEBI:3990 synonym: "." RELATED FORMULA [ChEBI:] synonym: "Cyclic amide" EXACT [KEGG COMPOUND:] synonym: "cyclic amide" EXACT [ChEBI:] synonym: "cyclic amides" RELATED [ChEBI:] xref: KEGG COMPOUND:C11824 "KEGG COMPOUND" is_a: CHEBI:32988 ! amide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23447 name: cyclic nucleotide namespace: chebi_ontology synonym: "cyclic nucleotides" RELATED [ChEBI:] synonym: "nucleoside cyclic phosphate" RELATED [ChEBI:] is_a: CHEBI:36976 ! nucleotide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23449 name: cyclic peptide namespace: chebi_ontology synonym: "cyclic peptides" RELATED [ChEBI:] synonym: "Cyclopeptid" RELATED [ChEBI:] synonym: "peptide cyclique" RELATED [IUPAC:] synonym: "peptido ciclico" RELATED [IUPAC:] synonym: "Zyklopeptid" RELATED [ChEBI:] is_a: CHEBI:16670 ! peptide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23450 name: cyclitol phosphate namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "cyclitol phosphates" RELATED [ChEBI:] is_a: CHEBI:23451 ! cyclitol is_a: CHEBI:25703 ! organic phosphate is_a: CHEBI:37734 ! phosphoric ester property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23451 name: cyclitol namespace: chebi_ontology def: "A polyol consisting of a cycloalkane containing at least three hydroxy groups, each attached to a different ring carbon atom." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "cyclitols" EXACT IUPAC_NAME [IUPAC:] is_a: CHEBI:26191 ! polyol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23482 name: cyclohexanones namespace: chebi_ontology def: "Any alicyclic ketone based on a cyclohexane skeleton and its substituted derivatives thereof." [] synonym: "cyclohexanones" EXACT [ChEBI:] is_a: CHEBI:36132 ! alicyclic ketone property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23509 name: cysteine derivative namespace: chebi_ontology def: "An amino acid derivative resulting from reaction of cysteine at the amino group, carboxy group, or thiol group, or from the replacement of any hydrogen of cysteine by a heteroatom. The definition normally excludes peptides containing cysteine residues." [] synonym: "cysteine derivative" EXACT [ChEBI:] synonym: "cysteine derivatives" RELATED [ChEBI:] is_a: CHEBI:83821 ! amino acid derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23527 name: cytochalasin B namespace: chebi_ontology def: "An organic heterotricyclic compound, that is a mycotoxin which is cell permeable an an inhibitor of cytoplasmic division by blocking the formation of contractile microfilaments." [] synonym: "(3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione" EXACT IUPAC_NAME [IUPAC:] synonym: "[H][C@@]12\\C=C\\C[C@H](C)CCC[C@@H](O)\\C=C\\C(=O)O[C@]11C(=O)N[C@@H](Cc3ccccc3)[C@]1([H])[C@H](C)C(=C)[C@H]2O" RELATED SMILES [ChEBI:] synonym: "C29H37NO5" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=GBOGMAARMMDZGR-TYHYBEHESA-N" RELATED InChIKey [ChEBI:] synonym: "Phomin" RELATED [ChEBI:] xref: ChemIDplus:14930-96-2 "CAS Registry Number" xref: CiteXplore:22882828 "PubMed citation" xref: KEGG COMPOUND:C19954 "KEGG COMPOUND" xref: LIPID MAPS:LMPK11000002 "LIPID MAPS instance" xref: Reaxys:1096210 "Reaxys Registry Number" xref: Wikipedia:Cytochalasin_B "Wikipedia" is_a: CHEBI:23528 ! cytochalasin is_a: CHEBI:24995 ! lactam is_a: CHEBI:25000 ! lactone is_a: CHEBI:26979 ! organic heterotricyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23528 name: cytochalasin namespace: chebi_ontology synonym: "cytochalasins" RELATED [ChEBI:] xref: Wikipedia:Cytochalasin "Wikipedia" is_a: CHEBI:24897 ! isoindoles property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23612 name: deoxyadenosine phosphate namespace: chebi_ontology synonym: "deoxyadenosine phosphates" RELATED [ChEBI:] is_a: CHEBI:61297 ! adenyl deoxyribonucleotide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23621 name: deoxycytidine phosphate namespace: chebi_ontology synonym: "deoxycytidine phosphates" RELATED [ChEBI:] synonym: "deoxycytosine phosphates" RELATED [ChEBI:] is_a: CHEBI:25608 ! nucleoside phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23623 name: deoxyglucose namespace: chebi_ontology def: "A deoxyhexose comprising glucose having at least one hydroxy group replaced by hydrogen." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "deoxyglucose" EXACT [ChEBI:] synonym: "deoxyglucoses" RELATED [ChEBI:] is_a: CHEBI:23628 ! deoxyhexose property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23625 name: deoxyguanosine phosphate namespace: chebi_ontology synonym: "deoxyguanosine phosphates" RELATED [ChEBI:] is_a: CHEBI:25608 ! nucleoside phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23628 name: deoxyhexose namespace: chebi_ontology def: "Any C6 deoxy sugar having at least one hydroxy group replaced by hydrogen." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "deoxyhexose" EXACT [ChEBI:] synonym: "deoxyhexoses" RELATED [ChEBI:] is_a: CHEBI:23639 ! deoxy sugar is_a: CHEBI:33917 ! aldohexose property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23634 name: deoxyaldopentose phosphate namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "deoxyaldopentose phosphates" RELATED [ChEBI:] synonym: "deoxypentose phosphate" RELATED [ChEBI:] synonym: "deoxypentose phosphates" RELATED [ChEBI:] is_a: CHEBI:25900 ! aldopentose phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23636 name: deoxyribonucleoside namespace: chebi_ontology synonym: "deoxyribonucleosides" RELATED [ChEBI:] is_a: CHEBI:33838 ! nucleoside property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23639 name: deoxy sugar namespace: chebi_ontology def: "Any sugar having a hydroxy group replaced with a hydrogen atom." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "deoxy sugars" RELATED [ChEBI:] synonym: "deoxysugar" RELATED [ChEBI:] synonym: "deoxysugars" RELATED [ChEBI:] is_a: CHEBI:16646 ! carbohydrate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23643 name: depsipeptide namespace: chebi_ontology def: "A natural or synthetic compound having a sequence of amino and hydroxy carboxylic acid residues (usually alpha-amino and alpha-hydroxy acids), commonly but not necessarily regularly alternating." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "Depsipeptid" RELATED [ChEBI:] synonym: "depsipeptides" EXACT IUPAC_NAME [IUPAC:] is_a: CHEBI:16670 ! peptide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23677 name: diazole namespace: chebi_ontology def: "An azole that is either one of a pair of heterocyclic organic compounds comprising three carbon atoms and two nitrogen atoms arranged in a ring." [] synonym: "diazoles" RELATED [ChEBI:] is_a: CHEBI:68452 ! azole property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23690 name: dicarboxylic acid amide namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "dicarboxylic acid amides" RELATED [ChEBI:] is_a: CHEBI:37622 ! carboxamide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23824 name: diol namespace: chebi_ontology def: "A compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic. Aliphatic diols are also called glycols." [] synonym: "diols" EXACT IUPAC_NAME [IUPAC:] synonym: "diols" RELATED [ChEBI:] xref: Wikipedia:Diol "Wikipedia" is_a: CHEBI:26191 ! polyol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23843 name: disaccharide phosphate namespace: chebi_ontology synonym: "disaccharide phosphates" RELATED [ChEBI:] is_a: CHEBI:26816 ! carbohydrate phosphate is_a: CHEBI:63353 ! disaccharide derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23853 name: dithiol namespace: chebi_ontology synonym: "dithiols" RELATED [ChEBI:] is_a: CHEBI:29256 ! thiol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23906 name: monoatomic cation namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "monoatomic cations" RELATED [ChEBI:] is_a: CHEBI:24867 ! monoatomic ion is_a: CHEBI:36916 ! cation property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23924 name: enzyme inhibitor namespace: chebi_ontology def: "A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "enzyme inhibitor" EXACT IUPAC_NAME [IUPAC:] synonym: "enzyme inhibitors" RELATED [ChEBI:] synonym: "inhibidor enzimatico" RELATED [ChEBI:] synonym: "inhibidores enzimaticos" RELATED [ChEBI:] synonym: "inhibiteur enzymatique" RELATED [ChEBI:] synonym: "inhibiteurs enzymatiques" RELATED [ChEBI:] is_a: CHEBI:35222 ! inhibitor is_a: CHEBI:52206 ! biochemical role property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23953 name: erythromycins namespace: chebi_ontology synonym: "erythromycins" EXACT [ChEBI:] is_a: CHEBI:25105 ! macrolide antibiotic property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23981 name: ethanolamines namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "ethanolamine" RELATED [ChEBI:] is_a: CHEBI:22478 ! amino alcohol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23982 name: ethanols namespace: chebi_ontology def: "Any primary alcohol based on an ethanol skeleton." [] synonym: "ethanols" EXACT [ChEBI:] is_a: CHEBI:15734 ! primary alcohol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:23994 name: ethyl methanesulfonate namespace: chebi_ontology def: "A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with ethanol." [] synonym: "C3H8O3S" RELATED FORMULA [ChEBI:] synonym: "CCOS(C)(=O)=O" RELATED SMILES [ChEBI:] synonym: "EMS" RELATED [ChemIDplus:] synonym: "ethyl mesylate" RELATED [ChemIDplus:] synonym: "ethyl methanesulphonate" RELATED [ChemIDplus:] synonym: "InChI=1S/C3H8O3S/c1-3-6-7(2,4)5/h3H2,1-2H3" RELATED InChI [ChEBI:] synonym: "InChIKey=PLUBXMRUUVWRLT-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "methylsulfonic acid ethyl ester" RELATED [ChemIDplus:] synonym: "methylsulfonic acid, ethyl ester" RELATED [ChemIDplus:] xref: ChemIDplus:62-50-0 "CAS Registry Number" xref: CiteXplore:16039156 "PubMed citation" xref: CiteXplore:19797863 "PubMed citation" xref: CiteXplore:20102787 "PubMed citation" xref: CiteXplore:24475756 "PubMed citation" xref: CiteXplore:24524729 "PubMed citation" xref: CiteXplore:24531730 "PubMed citation" xref: CiteXplore:24728647 "PubMed citation" xref: CiteXplore:6936603 "PubMed citation" xref: CiteXplore:7285888 "PubMed citation" xref: KEGG COMPOUND:62-50-0 "CAS Registry Number" xref: KEGG COMPOUND:C19239 "KEGG COMPOUND" xref: NIST Chemistry WebBook:62-50-0 "CAS Registry Number" xref: Reaxys:773969 "Reaxys Registry Number" xref: Wikipedia:Ethyl_methanesulfonate "Wikipedia" is_a: CHEBI:25223 ! methanesulfonate ester property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24018 name: farnesyl phosphate namespace: chebi_ontology synonym: "farnesyl phosphates" RELATED [ChEBI:] is_a: CHEBI:16460 ! polyprenol phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24060 name: fluoride salt namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "fluoride salts" RELATED [ChEBI:] synonym: "fluorides" RELATED [ChEBI:] is_a: CHEBI:24062 ! fluorine molecular entity is_a: CHEBI:33958 ! halide salt property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24062 name: fluorine molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "fluorine compounds" RELATED [ChEBI:] synonym: "fluorine molecular entities" RELATED [ChEBI:] synonym: "fluorine molecular entity" EXACT [ChEBI:] is_a: CHEBI:24471 ! halogen molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24079 name: formamides namespace: chebi_ontology def: "Amides with the general formula R(1)R(2)NCHO (R(1) and R(2) can be H)." [] synonym: "." RELATED FORMULA [ChEBI:] is_a: CHEBI:37622 ! carboxamide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24265 name: gluconate namespace: chebi_ontology synonym: "C6H11O7" RELATED FORMULA [ChEBI:] synonym: "gluconate" EXACT IUPAC_NAME [IUPAC:] synonym: "gluconates" RELATED [ChEBI:] is_a: CHEBI:33804 ! gluconates property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24268 name: glucooligosaccharide namespace: chebi_ontology def: "An oligosaccharide comprised of glucose residues." [] synonym: "glucooligosaccharides" RELATED [ChEBI:] is_a: CHEBI:50699 ! oligosaccharide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24278 name: glucoside namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "glucosides" RELATED [ChEBI:] is_a: CHEBI:35313 ! hexoside property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24318 name: glutamine family amino acid namespace: chebi_ontology def: "An L-alpha-amino acid which is L-glutamic acid or any of the essential amino acids biosynthesised from it (glutamine, proline and arginine). A closed class." [] synonym: "glutamine family amino acids" RELATED [ChEBI:] xref: CiteXplore:20716061 "PubMed citation" is_a: CHEBI:15705 ! L-alpha-amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24337 name: glutathione derivative namespace: chebi_ontology def: "Any organonitrogen compound derived from the Glu-Cys-Gly tripeptide glutathione." [] synonym: "glutathione derivatives" RELATED [ChEBI:] is_a: CHEBI:33261 ! organosulfur compound is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:36963 ! organooxygen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24395 name: glycopeptide antibiotic namespace: chebi_ontology synonym: "glycopeptide antibiotics" RELATED [ChEBI:] is_a: CHEBI:24396 ! glycopeptide is_a: CHEBI:25903 ! peptide antibiotic property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24396 name: glycopeptide namespace: chebi_ontology alt_id: CHEBI:5478 def: "A peptide that has formula C36H64N8O17." [] synonym: "C36H64N8O17" RELATED FORMULA [KEGG COMPOUND:] synonym: "CCN[C@H]1C(O)O[C@H](CO)C(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2NC(C)=O)[C@@H]1OC(C)C(=O)N[C@H](C)C(=O)N[C@H](CCC(=O)N[C@H](CCCCN)C(=O)N[C@@H](C)C(O)=O)C(N)=O" RELATED SMILES [ChEBI:] synonym: "Glycopeptide" EXACT [KEGG COMPOUND:] synonym: "glycopeptides" EXACT IUPAC_NAME [IUPAC:] synonym: "InChI=1S/C36H64N8O17/c1-6-39-25-29(28(22(14-46)59-35(25)57)61-36-24(42-18(5)47)27(50)26(49)21(13-45)60-36)58-17(4)32(53)40-15(2)31(52)44-19(30(38)51)10-11-23(48)43-20(9-7-8-12-37)33(54)41-16(3)34(55)56/h15-17,19-22,24-29,35-36,39,45-46,49-50,57H,6-14,37H2,1-5H3,(H2,38,51)(H,40,53)(H,41,54)(H,42,47)(H,43,48)(H,44,52)(H,55,56)/t15-,16+,17?,19-,20-,21-,22-,24-,25-,26-,27-,28?,29-,35?,36+/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=DQJCDTNMLBYVAY-QVGCMXBISA-N" RELATED InChIKey [ChEBI:] xref: KEGG COMPOUND:C00528 "KEGG COMPOUND" is_a: CHEBI:16670 ! peptide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24397 name: glycophospholipid namespace: chebi_ontology def: "Any phospholipid that contain both phosphate and carbohydrate as integral structural components." [] synonym: "glycophospholipid" EXACT [ChEBI:] synonym: "glycophospholipids" RELATED [ChEBI:] synonym: "phosphoglycolipids" RELATED [ChEBI:] is_a: CHEBI:16247 ! phospholipid is_a: CHEBI:33563 ! glycolipid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24400 name: glycoside namespace: chebi_ontology def: "A glycosyl compound resulting from the attachment of a glycosyl group to a non-acyl group RO-, RS-, RSe-, etc. The bond between the glycosyl group and the non-acyl group is called a glycosidic bond. By extension, the terms N-glycosides and C-glycosides are used as class names for glycosylamines and for compounds having a glycosyl group attached to a hydrocarbyl group respectively. These terms are misnomers and should not be used. The preferred terms are glycosylamines and C-glycosyl compounds, respectively." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "glycosides" EXACT IUPAC_NAME [IUPAC:] synonym: "glycosides" RELATED [ChEBI:] synonym: "O-glycoside" RELATED [ChEBI:] synonym: "O-glycosides" RELATED [ChEBI:] is_a: CHEBI:63161 ! glycosyl compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24405 name: glycosylglucose namespace: chebi_ontology synonym: "glycosylglucoses" RELATED [ChEBI:] is_a: CHEBI:36233 ! disaccharide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24407 name: glycosyl glycoside namespace: chebi_ontology def: "Any disaccharide in which the two monosaccharide components are connected by a glycosidic linkage between their anomeric centres." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "glycosyl glycoside" EXACT [ChEBI:] synonym: "glycosyl glycosides" RELATED [ChEBI:] is_a: CHEBI:36233 ! disaccharide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24431 name: chemical entity namespace: chebi_ontology def: "A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "grouped_by_chemistry" RELATED [ChEBI:] property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24432 name: biological role namespace: chebi_ontology def: "A role played by the molecular entity or part thereof within a biological context." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "biological function" RELATED [ChEBI:] synonym: "grouped_by_functions" RELATED [ChEBI:] is_a: CHEBI:50906 ! role property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24433 name: group namespace: chebi_ontology def: "A defined linked collection of atoms or a single atom within a molecular entity." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "group" EXACT IUPAC_NAME [IUPAC:] synonym: "groupe" RELATED [IUPAC:] synonym: "grupo" RELATED [IUPAC:] synonym: "grupos" RELATED [IUPAC:] synonym: "Gruppe" RELATED [ChEBI:] synonym: "Rest" RELATED [ChEBI:] is_a: CHEBI:24431 ! chemical entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24436 name: guanidines namespace: chebi_ontology def: "Any organonitrogen compound containing a carbamimidamido (guanidino) group. Guanidines have the general structure (R(1)R(2)N)(R(3)R(4)N)C=N-R(5) and are related structurally to amidines and ureas." [] synonym: "guanidines" EXACT [ChEBI:] is_a: CHEBI:35352 ! organonitrogen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24471 name: halogen molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "halogen compounds" RELATED [ChEBI:] synonym: "halogen molecular entities" RELATED [ChEBI:] synonym: "halogen molecular entity" EXACT [ChEBI:] is_a: CHEBI:33675 ! p-block molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:2450 name: aculeacin A namespace: chebi_ontology def: "A lipopeptide that is isolated from Aspergillus aculeatus and exhibits antifungal activity." [] synonym: "Aculeacin A" EXACT [KEGG COMPOUND:] synonym: "aculeacin A" EXACT [IUBMB:] synonym: "Aculeacins" RELATED [ChemIDplus:] synonym: "C51H82N8O17" RELATED FORMULA [ChEBI:] synonym: "C51H85N7O16" RELATED FORMULA [KEGG COMPOUND:] synonym: "CCCCCCCCCCCCCCCC(=O)N[C@H]1C[C@@H](O)[C@@H](O)NC(=O)[C@@H]2[C@@H](O)[C@@H](C)CN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC1=O)[C@@H](C)O)[C@H](O)[C@@H](O)c1ccc(O)cc1)[C@H](O)CC(N)=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C51H82N8O17/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-37(66)53-32-23-35(64)47(72)57-49(74)41-42(67)27(2)25-59(41)51(76)39(34(63)24-36(52)65)55-48(73)40(44(69)43(68)29-18-20-30(61)21-19-29)56-46(71)33-22-31(62)26-58(33)50(75)38(28(3)60)54-45(32)70/h18-21,27-28,31-35,38-44,47,60-64,67-69,72H,4-17,22-26H2,1-3H3,(H2,52,65)(H,53,66)(H,54,70)(H,55,73)(H,56,71)(H,57,74)/t27-,28+,31+,32-,33-,34+,35+,38-,39-,40-,41-,42-,43-,44-,47+/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=FBCLKBXYZRAXNA-PDIPHZEPSA-N" RELATED InChIKey [ChEBI:] xref: ChemIDplus:58814-86-1 "CAS Registry Number" xref: CiteXplore:324959 "PubMed citation" xref: CiteXplore:324960 "PubMed citation" xref: CiteXplore:3325782 "PubMed citation" xref: CiteXplore:7042670 "PubMed citation" xref: CiteXplore:7042671 "PubMed citation" xref: CiteXplore:7425782 "PubMed citation" xref: KEGG COMPOUND:58814-86-1 "CAS Registry Number" xref: KEGG COMPOUND:C01776 "KEGG COMPOUND" xref: KNApSAcK:C00016077 "KNApSAcK" xref: MetaCyc:CPD-13365 "MetaCyc" xref: Reaxys:26317172 "Reaxys Registry Number" is_a: CHEBI:24533 ! heterodetic cyclic peptide is_a: CHEBI:46895 ! lipopeptide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24531 name: heterocyclic antibiotic namespace: chebi_ontology synonym: "heterocyclic antibiotics" RELATED [ChEBI:] is_a: CHEBI:24532 ! organic heterocyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24532 name: organic heterocyclic compound namespace: chebi_ontology def: "A cyclic compound having as ring members atoms of carbon and at least of one other element." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "organic heterocycle" RELATED [ChEBI:] synonym: "organic heterocyclic compounds" RELATED [ChEBI:] xref: ChEBI:C03123 "KEGG COMPOUND" is_a: CHEBI:33285 ! heteroorganic entity is_a: CHEBI:33832 ! organic cyclic compound is_a: CHEBI:5686 ! heterocyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24533 name: heterodetic cyclic peptide namespace: chebi_ontology def: "A heterodetic cyclic peptide is a peptide consisting only of amino-acid residues, but in which the linkages forming the ring are not solely peptide bonds; one or more is an isopeptide, disulfide, ester, or other bond." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "heterodetic cyclic peptide" EXACT IUPAC_NAME [IUPAC:] synonym: "heterodetic cyclic peptides" RELATED [ChEBI:] synonym: "peptide cyclique heterodetique" RELATED [IUPAC:] synonym: "peptido ciclico heterodetico" RELATED [IUPAC:] is_a: CHEBI:23449 ! cyclic peptide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24583 name: hexitol namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "hexitol" EXACT [ChEBI:] synonym: "hexitols" RELATED [ChEBI:] is_a: CHEBI:17522 ! alditol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24599 name: histidine derivative namespace: chebi_ontology def: "An amino acid derivative resulting from reaction of histidine at the amino group or the carboxy group, or from the replacement of any hydrogen of histidine by a heteroatom. The definition normally excludes peptides containing alanine residues." [] synonym: "histidine derivatives" RELATED [ChEBI:] is_a: CHEBI:83821 ! amino acid derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24610 name: homocysteines namespace: chebi_ontology synonym: "homocysteine derivative" RELATED [ChEBI:] synonym: "homocysteine derivatives" RELATED [ChEBI:] synonym: "homocysteines" EXACT [ChEBI:] xref: ChEBI:C05330 "KEGG COMPOUND" is_a: CHEBI:83925 ! non-proteinogenic alpha-amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24613 name: homodetic cyclic peptide namespace: chebi_ontology def: "A homodetic cyclic peptide is a cyclic peptide in which the ring consists solely of amino-acid residues in peptide linkages." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "homodetic cyclic peptide" EXACT IUPAC_NAME [IUPAC:] synonym: "homodetic cyclic peptides" RELATED [ChEBI:] synonym: "peptide cyclique homodetique" RELATED [IUPAC:] synonym: "peptido ciclico homodetico" RELATED [IUPAC:] is_a: CHEBI:23449 ! cyclic peptide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24632 name: hydrocarbon namespace: chebi_ontology def: "A compound consisting of carbon and hydrogen only." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "hidrocarburo" RELATED [IUPAC:] synonym: "hidrocarburos" RELATED [IUPAC:] synonym: "hydrocarbon" EXACT IUPAC_NAME [IUPAC:] synonym: "hydrocarbons" EXACT IUPAC_NAME [IUPAC:] synonym: "hydrocarbure" RELATED [IUPAC:] synonym: "Kohlenwasserstoff" RELATED [ChEBI:] synonym: "Kohlenwasserstoffe" RELATED [ChEBI:] is_a: CHEBI:33245 ! organic fundamental parent property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24646 name: hydroquinones namespace: chebi_ontology def: "Benzenediol compounds having the hydroxy substituents in the 1- and 4-positions." [] is_a: CHEBI:33570 ! benzenediols property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24650 name: hydroxamic acid namespace: chebi_ontology def: "A compound, RkE(=O)lNHOH, derived from an oxoacid RkE(=O)l(OH) (l =/= 0) by replacing -OH with -NHOH, and derivatives thereof. Specific examples of hydroxamic acids are preferably named as N-hydroxy amides." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "hydroxamic acids" EXACT IUPAC_NAME [IUPAC:] synonym: "hydroxamic acids" RELATED [ChEBI:] synonym: "N-hydroxy amide" RELATED [ChEBI:] synonym: "N-hydroxy amides" RELATED [ChEBI:] synonym: "N-hydroxy-amide" RELATED [ChEBI:] synonym: "N-hydroxy-amides" RELATED [ChEBI:] synonym: "N-hydroxyamide" RELATED [ChEBI:] synonym: "N-hydroxyamides" RELATED [ChEBI:] is_a: CHEBI:37622 ! carboxamide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24651 name: hydroxides namespace: chebi_ontology def: "Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH(-))." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "hydroxides" EXACT [ChEBI:] is_a: CHEBI:25806 ! oxygen molecular entity is_a: CHEBI:33608 ! hydrogen molecular entity is_a: CHEBI:37577 ! heteroatomic molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24654 name: hydroxy fatty acid namespace: chebi_ontology def: "Any fatty acid carrying one or more hydroxy substituents." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "hydroxy fatty acids" RELATED [LIPID MAPS:] synonym: "hydroxy fatty acids" RELATED [ChEBI:] xref: CiteXplore:18296335 "PubMed citation" xref: CiteXplore:6419288 "PubMed citation" xref: CiteXplore:8274032 "PubMed citation" xref: LIPID MAPS:LMFA0105 "LIPID MAPS class" is_a: CHEBI:35366 ! fatty acid is_a: CHEBI:35868 ! hydroxy monocarboxylic acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24669 name: hydroxy carboxylic acid namespace: chebi_ontology def: "Any carboxylic acid with at least one hydroxy group." [] synonym: "hydroxy carboxylic acids" RELATED [ChEBI:] synonym: "hydroxyacids" RELATED [ChEBI:] is_a: CHEBI:33575 ! carboxylic acid is_a: CHEBI:33822 ! organic hydroxy compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24745 name: hydroxypyridine namespace: chebi_ontology def: "Any member of the class of pyridines with at least one hydroxy substituent." [] synonym: "hydroxypyridines" RELATED [ChEBI:] is_a: CHEBI:26421 ! pyridines is_a: CHEBI:74818 ! heteroaryl hydroxy compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24753 name: hygromycin namespace: chebi_ontology synonym: "hygromycins" RELATED [ChEBI:] is_a: CHEBI:22479 ! amino cyclitol glycoside is_a: CHEBI:22507 ! aminoglycoside antibiotic property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24780 name: imidazoles namespace: chebi_ontology def: "A five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton." [] synonym: "imidazoles" EXACT [ChEBI:] is_a: CHEBI:23677 ! diazole property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24782 name: imide namespace: chebi_ontology synonym: "imide" EXACT [ChEBI:] synonym: "imides" RELATED [ChEBI:] is_a: CHEBI:33257 ! secondary amide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24828 name: indoles namespace: chebi_ontology def: "Any compound containing an indole skeleton." [] synonym: "indoles" EXACT [ChEBI:] is_a: CHEBI:22728 ! benzopyrrole property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24829 name: indolones namespace: chebi_ontology synonym: "indolones" EXACT [ChEBI:] is_a: CHEBI:24828 ! indoles property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24833 name: oxoacid namespace: chebi_ontology def: "A compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "inorganic acids" RELATED [ChEBI:] synonym: "oxacids" RELATED [ChEBI:] synonym: "oxiacids" RELATED [ChEBI:] synonym: "oxo acid" RELATED [ChEBI:] synonym: "oxoacid" EXACT IUPAC_NAME [IUPAC:] synonym: "oxoacids" EXACT IUPAC_NAME [IUPAC:] synonym: "oxy-acids" RELATED [ChEBI:] synonym: "oxyacids" RELATED [ChEBI:] is_a: CHEBI:24651 ! hydroxides property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24834 name: inorganic anion namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "inorganic anions" RELATED [ChEBI:] is_a: CHEBI:22563 ! anion is_a: CHEBI:36914 ! inorganic ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24835 name: inorganic molecular entity namespace: chebi_ontology def: "A molecular entity that contains no carbon." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "anorganische Verbindungen" RELATED [ChEBI:] synonym: "inorganic compounds" RELATED [ChEBI:] synonym: "inorganic entity" RELATED [ChEBI:] synonym: "inorganic molecular entities" RELATED [ChEBI:] synonym: "inorganics" RELATED [ChEBI:] is_a: CHEBI:23367 ! molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24836 name: inorganic oxide namespace: chebi_ontology synonym: "inorganic oxides" RELATED [ChEBI:] is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:25741 ! oxide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24837 name: inorganic peroxide namespace: chebi_ontology def: "Compounds of structure ROOR' in which R and R' are inorganic groups." [] synonym: "inorganic peroxide" EXACT [ChEBI:] synonym: "inorganic peroxides" RELATED [ChEBI:] is_a: CHEBI:24836 ! inorganic oxide is_a: CHEBI:25940 ! peroxides property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24839 name: inorganic salt namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "anorganisches Salz" RELATED [ChEBI:] synonym: "inorganic salts" RELATED [ChEBI:] is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:24866 ! salt property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24846 name: inositol phosphate namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "inositol phosphates" RELATED [ChEBI:] is_a: CHEBI:23450 ! cyclitol phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24860 name: iodine molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "iodine compounds" RELATED [ChEBI:] synonym: "iodine molecular entities" RELATED [ChEBI:] synonym: "iodine molecular entity" EXACT [ChEBI:] is_a: CHEBI:24471 ! halogen molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24866 name: salt namespace: chebi_ontology def: "A salt is an assembly of cations and anions." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "ionic compound" RELATED [ChEBI:] synonym: "ionic compounds" RELATED [ChEBI:] synonym: "sal" RELATED [ChEBI:] synonym: "sales" RELATED [ChEBI:] synonym: "salt" EXACT IUPAC_NAME [IUPAC:] synonym: "salts" RELATED [ChEBI:] synonym: "Salz" RELATED [ChEBI:] synonym: "Salze" RELATED [ChEBI:] synonym: "sel" RELATED [ChEBI:] synonym: "sels" RELATED [ChEBI:] is_a: CHEBI:37577 ! heteroatomic molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24867 name: monoatomic ion namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "ionic elements" RELATED [ChEBI:] synonym: "monoatomic ions" RELATED [ChEBI:] is_a: CHEBI:24870 ! ion is_a: CHEBI:33238 ! monoatomic entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24868 name: organic salt namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "organic salts" RELATED [ChEBI:] synonym: "organisches Salz" RELATED [ChEBI:] is_a: CHEBI:24866 ! salt property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24870 name: ion namespace: chebi_ontology def: "A molecular entity having a net electric charge." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "Ion" EXACT [ChEBI:] synonym: "ion" EXACT [ChEBI:] synonym: "ion" EXACT IUPAC_NAME [IUPAC:] synonym: "Ionen" RELATED [ChEBI:] synonym: "iones" RELATED [ChEBI:] synonym: "ions" RELATED [ChEBI:] is_a: CHEBI:23367 ! molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24873 name: iron molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "iron compounds" RELATED [ChEBI:] synonym: "iron molecular entities" RELATED [ChEBI:] synonym: "iron molecular entity" EXACT [ChEBI:] is_a: CHEBI:33744 ! iron group molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24875 name: iron cation namespace: chebi_ontology synonym: "Fe" RELATED FORMULA [ChEBI:] synonym: "Fe cation" RELATED [UniProt:] synonym: "iron cation" EXACT IUPAC_NAME [IUPAC:] synonym: "iron cations" RELATED [ChEBI:] is_a: CHEBI:33515 ! transition element cation is_a: CHEBI:82663 ! elemental iron property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24897 name: isoindoles namespace: chebi_ontology synonym: "isoindoles" EXACT [ChEBI:] is_a: CHEBI:22728 ! benzopyrrole property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24898 name: isoleucine namespace: chebi_ontology def: "A 2-amino-3-methylpentanoic acid having either (2R,3R)- or (2S,3S)-configuration." [] synonym: "Hile" RELATED [IUPAC:] synonym: "isoleucine" EXACT IUPAC_NAME [IUPAC:] synonym: "rel-(2R,3R)-2-amino-3-methylpentanoic acid" RELATED [IUPAC:] xref: Beilstein:1721790 "Beilstein Registry Number" xref: ChemIDplus:443-79-8 "CAS Registry Number" xref: CiteXplore:17190852 "PubMed citation" xref: NIST Chemistry WebBook:443-79-8 "CAS Registry Number" xref: Reaxys:1721790 "Reaxys Registry Number" is_a: CHEBI:38264 ! 2-amino-3-methylpentanoic acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24913 name: isoprenoid namespace: chebi_ontology def: "Any lipid formally derived from isoprene (2-methylbuta-1,3-diene), the skeleton of which can generally be discerned in repeated occurrence in the molecule. The skeleton of isoprenoids may differ from strict additivity of isoprene units by loss or shift of a fragment, commonly a methyl group. The class includes both hydrocarbons and oxygenated derivatives." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "isoprenoid" EXACT [ChEBI:] synonym: "isoprenoids" EXACT IUPAC_NAME [IUPAC:] synonym: "isoprenoids" RELATED [ChEBI:] xref: CiteXplore:12769708 "PubMed citation" xref: CiteXplore:19219049 "PubMed citation" xref: LIPID MAPS:LMPR01 "LIPID MAPS class" is_a: CHEBI:18059 ! lipid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24960 name: ketoaldehyde namespace: chebi_ontology alt_id: CHEBI:6124 synonym: "C2HO2R" RELATED FORMULA [KEGG COMPOUND:] synonym: "Ketoaldehyde" EXACT [KEGG COMPOUND:] synonym: "ketoaldehydes" RELATED [ChEBI:] xref: KEGG COMPOUND:C01928 "KEGG COMPOUND" is_a: CHEBI:17087 ! ketone is_a: CHEBI:17478 ! aldehyde property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24973 name: ketohexose namespace: chebi_ontology def: "Any hexose containing a single ketone group." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "ketohexose" EXACT [ChEBI:] synonym: "ketohexoses" RELATED [ChEBI:] is_a: CHEBI:18133 ! hexose is_a: CHEBI:24978 ! ketose property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24978 name: ketose namespace: chebi_ontology alt_id: CHEBI:6131 def: "A monosaccharide that has formula .." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "C6H12O6" RELATED FORMULA [KEGG COMPOUND:] synonym: "InChI=1S/C6H12O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-5,7-11H,1-2H2" RELATED InChI [ChEBI:] synonym: "InChIKey=DWJZKGYQNOQQEZ-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "Ketose" EXACT [KEGG COMPOUND:] synonym: "ketose" EXACT [ChEBI:] synonym: "ketoses" RELATED [ChEBI:] synonym: "OCC(O)C(O)C(=O)C(O)CO" RELATED SMILES [ChEBI:] xref: KEGG COMPOUND:C01383 "KEGG COMPOUND" is_a: CHEBI:35381 ! monosaccharide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24982 name: ketotriose namespace: chebi_ontology def: "Any ketone-containing triose." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "ketotriose" EXACT [ChEBI:] synonym: "ketotrioses" RELATED [ChEBI:] is_a: CHEBI:24978 ! ketose is_a: CHEBI:27137 ! triose property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:24995 name: lactam namespace: chebi_ontology def: "Cyclic amides of amino carboxylic acids, having a 1-azacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "lactam" EXACT [IUPAC:] synonym: "lactams" EXACT IUPAC_NAME [IUPAC:] synonym: "lactams" RELATED [ChEBI:] synonym: "Laktam" RELATED [ChEBI:] synonym: "Laktame" RELATED [ChEBI:] is_a: CHEBI:23443 ! cyclic amide is_a: CHEBI:38101 ! organonitrogen heterocyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25000 name: lactone namespace: chebi_ontology def: "Any cyclic carboxylic ester containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "Lacton" RELATED [ChEBI:] synonym: "lactona" RELATED [IUPAC:] synonym: "lactonas" RELATED [IUPAC:] synonym: "lactone" EXACT IUPAC_NAME [IUPAC:] synonym: "lactones" EXACT IUPAC_NAME [IUPAC:] synonym: "Lakton" RELATED [ChEBI:] synonym: "Laktone" RELATED [ChEBI:] is_a: CHEBI:33308 ! carboxylic ester is_a: CHEBI:38104 ! oxacycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25017 name: leucine namespace: chebi_ontology def: "A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isobutyl group." [] synonym: "(+-)-Leucine" RELATED [ChemIDplus:] synonym: "(RS)-Leucine" RELATED [ChemIDplus:] synonym: "2-amino-4-methylpentanoic acid" RELATED [IUPAC:] synonym: "C6H13NO2" RELATED FORMULA [ChEBI:] synonym: "CC(C)CC(N)C(O)=O" RELATED SMILES [ChEBI:] synonym: "DL-Leucine" RELATED [ChemIDplus:] synonym: "Hleu" RELATED [IUPAC:] synonym: "InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)" RELATED InChI [ChEBI:] synonym: "InChIKey=ROHFNLRQFUQHCH-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "L" RELATED [ChEBI:] synonym: "Leu" RELATED [ChEBI:] synonym: "Leucin" RELATED [ChEBI:] synonym: "leucine" EXACT IUPAC_NAME [IUPAC:] synonym: "Leuzin" RELATED [ChEBI:] xref: Beilstein:636005 "Beilstein Registry Number" xref: ChemIDplus:328-39-2 "CAS Registry Number" xref: CiteXplore:17439666 "PubMed citation" xref: Gmelin:50203 "Gmelin Registry Number" xref: KEGG COMPOUND:C16439 "KEGG COMPOUND" xref: LIPID MAPS:LMFA01100048 "LIPID MAPS instance" xref: NIST Chemistry WebBook:328-39-2 "CAS Registry Number" xref: Reaxys:636005 "Reaxys Registry Number" xref: Wikipedia:Leucine "Wikipedia" is_a: CHEBI:22918 ! branched-chain amino acid is_a: CHEBI:33704 ! alpha-amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25094 name: lysine namespace: chebi_ontology def: "A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6." [] synonym: "2,6-diaminohexanoic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "alpha,epsilon-diaminocaproic acid" RELATED [ChEBI:] synonym: "C6H14N2O2" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)" RELATED InChI [ChEBI:] synonym: "InChIKey=KDXKERNSBIXSRK-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "K" RELATED [ChEBI:] synonym: "LYS" RELATED [ChEBI:] synonym: "Lysin" RELATED [ChEBI:] synonym: "lysine" EXACT IUPAC_NAME [IUPAC:] synonym: "NCCCCC(N)C(O)=O" RELATED SMILES [ChEBI:] xref: Beilstein:1616991 "Beilstein Registry Number" xref: ChemIDplus:70-54-2 "CAS Registry Number" xref: CiteXplore:17439666 "PubMed citation" xref: CiteXplore:22264337 "PubMed citation" xref: Gmelin:279284 "Gmelin Registry Number" xref: KEGG COMPOUND:C16440 "KEGG COMPOUND" xref: NIST Chemistry WebBook:70-54-2 "CAS Registry Number" xref: Reaxys:1616991 "Reaxys Registry Number" xref: Wikipedia:Lysine "Wikipedia" is_a: CHEBI:33704 ! alpha-amino acid is_a: CHEBI:35987 ! diamino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25105 name: macrolide antibiotic namespace: chebi_ontology def: "A macrocyclic lactone with a ring of twelve or more members which exhibits antibiotic activity." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "macrolide antibiotics" RELATED [ChEBI:] synonym: "Makrolidantibiotika" RELATED [ChEBI:] is_a: CHEBI:25106 ! macrolide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25106 name: macrolide namespace: chebi_ontology def: "A macrocyclic lactone with a ring of twelve or more members derived from a polyketide." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "macrolide" EXACT [ChEBI:] synonym: "macrolides" EXACT IUPAC_NAME [IUPAC:] synonym: "macrolides" RELATED [ChEBI:] synonym: "Makrolid" RELATED [ChEBI:] xref: Wikipedia:Macrolide "Wikipedia" is_a: CHEBI:26188 ! polyketide is_a: CHEBI:63944 ! macrocyclic lactone property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25108 name: magnesium molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "magnesium compounds" RELATED [ChEBI:] synonym: "magnesium molecular entities" RELATED [ChEBI:] synonym: "magnesium molecular entity" EXACT [ChEBI:] is_a: CHEBI:33299 ! alkaline earth molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25154 name: manganese molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "manganese compounds" RELATED [ChEBI:] synonym: "manganese molecular entities" RELATED [ChEBI:] synonym: "manganese molecular entity" EXACT [ChEBI:] is_a: CHEBI:33743 ! manganese group molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25155 name: manganese cation namespace: chebi_ontology synonym: "manganese cation" EXACT IUPAC_NAME [IUPAC:] synonym: "manganese cations" RELATED [ChEBI:] synonym: "Mn" RELATED FORMULA [ChEBI:] is_a: CHEBI:33515 ! transition element cation is_a: CHEBI:35115 ! elemental manganese property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25189 name: 1,4-dimercaptobutane-2,3-diol namespace: chebi_ontology def: "A glycol that is butane-2,3-diol in which a hydrogen from each of the methyl groups is replaced by a thiol group." [] synonym: "1,4-dimercapto-2,3-butanediol" RELATED [ChemIDplus:] synonym: "1,4-dimercaptobutane-2,3-diol" EXACT [ChemIDplus:] synonym: "1,4-disulfanylbutane-2,3-diol" EXACT IUPAC_NAME [IUPAC:] synonym: "C4H10O2S2" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2" RELATED InChI [ChEBI:] synonym: "InChIKey=VHJLVAABSRFDPM-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "OC(CS)C(O)CS" RELATED SMILES [ChEBI:] xref: Beilstein:8141671 "Beilstein Registry Number" xref: ChemIDplus:7634-42-6 "CAS Registry Number" is_a: CHEBI:13643 ! glycol is_a: CHEBI:22944 ! butanediols property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25196 name: mercury molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "mercury compounds" RELATED [ChEBI:] synonym: "mercury molecular entities" RELATED [ChEBI:] is_a: CHEBI:33673 ! zinc group molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25197 name: mercury cation namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "mercury cations" RELATED [ChEBI:] synonym: "mercury ions" RELATED [ChEBI:] is_a: CHEBI:33515 ! transition element cation is_a: CHEBI:35113 ! elemental mercury property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25213 name: metal cation namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "a metal cation" RELATED [UniProt:] synonym: "metal cations" RELATED [ChEBI:] is_a: CHEBI:23906 ! monoatomic cation is_a: CHEBI:36915 ! inorganic cation property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25223 name: methanesulfonate ester namespace: chebi_ontology def: "An organosulfonic ester resulting from the formal condensation of methanesulfonic acid with the hydroxy group of an alcohol, phenol, heteroarenol, or enol." [] synonym: "CH3O3S" RELATED FORMULA [ChEBI:] synonym: "CS(=O)(=O)O[*]" RELATED SMILES [ChEBI:] synonym: "mesylate ester" RELATED [ChEBI:] synonym: "mesylate esters" RELATED [ChEBI:] synonym: "methanesulfonate esters" RELATED [ChEBI:] synonym: "methanesulfonates" RELATED [ChEBI:] synonym: "methanesulfonic acid esters" RELATED [ChEBI:] is_a: CHEBI:48544 ! methanesulfonates is_a: CHEBI:83347 ! organosulfonic ester property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25230 name: methionine derivative namespace: chebi_ontology def: "An amino acid derivative resulting from reaction of methionine at the amino group or the carboxy group, or from the replacement of any hydrogen of methionine by a heteroatom. The definition normally excludes peptides containing methionine residues." [] synonym: "methionine derivatives" RELATED [ChEBI:] is_a: CHEBI:83821 ! amino acid derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25255 name: methyl methanesulfonate namespace: chebi_ontology def: "A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with methanol." [] synonym: "as-Dimethyl sulfite" RELATED [ChemIDplus:] synonym: "C2H6O3S" RELATED FORMULA [ChEBI:] synonym: "CB1540" RELATED [ChEBI:] synonym: "COS(C)(=O)=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C2H6O3S/c1-5-6(2,3)4/h1-2H3" RELATED InChI [ChEBI:] synonym: "InChIKey=MBABOKRGFJTBAE-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "Methanesulfonic acid methyl ester" RELATED [ChemIDplus:] synonym: "Methyl mesylate" RELATED [ChemIDplus:] synonym: "methyl methanesulfonate" EXACT IUPAC_NAME [IUPAC:] synonym: "MMS" RELATED [ChemIDplus:] synonym: "MMS" RELATED [KEGG COMPOUND:] xref: ChemIDplus:66-27-3 "CAS Registry Number" xref: CiteXplore:11016630 "PubMed citation" xref: CiteXplore:14761437 "PubMed citation" xref: CiteXplore:16764919 "PubMed citation" xref: CiteXplore:21353429 "PubMed citation" xref: CiteXplore:21860482 "PubMed citation" xref: CiteXplore:22907509 "PubMed citation" xref: CiteXplore:23117069 "PubMed citation" xref: CiteXplore:23384783 "PubMed citation" xref: CiteXplore:23483329 "PubMed citation" xref: KEGG COMPOUND:66-27-3 "CAS Registry Number" xref: KEGG COMPOUND:C19181 "KEGG COMPOUND" xref: MetaCyc:CPD-7038 "MetaCyc" xref: Reaxys:1098586 "Reaxys Registry Number" xref: Wikipedia:Methyl_methanesulfonate "Wikipedia" is_a: CHEBI:25223 ! methanesulfonate ester property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25274 name: methylamines namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] is_a: CHEBI:22331 ! alkylamines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25340 name: methylpyridines namespace: chebi_ontology def: "Any member of the class of pyridines that carries at least one methyl substituent." [] synonym: "methylpyridines" EXACT [ChEBI:] is_a: CHEBI:26421 ! pyridines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25348 name: methylxanthine namespace: chebi_ontology synonym: "methylxanthines" RELATED [ChEBI:] is_a: CHEBI:26385 ! purine alkaloid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25357 name: mitomycin namespace: chebi_ontology synonym: "mitomycins" RELATED [ChEBI:] is_a: CHEBI:23003 ! carbamate ester is_a: CHEBI:36141 ! quinone is_a: CHEBI:38303 ! azirinopyrroloindole property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25367 name: molecule namespace: chebi_ontology def: "Any polyatomic entity that is an electrically neutral entity consisting of more than one atom." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "molecula" RELATED [IUPAC:] synonym: "molecule" EXACT [IUPAC:] synonym: "molecules" RELATED [IUPAC:] synonym: "Molekuel" RELATED [ChEBI:] synonym: "neutral molecular compounds" RELATED [IUPAC:] is_a: CHEBI:36357 ! polyatomic entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25370 name: molybdenum molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "molybdenum compounds" RELATED [ChEBI:] synonym: "molybdenum molecular entities" RELATED [ChEBI:] is_a: CHEBI:33741 ! chromium group molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25384 name: monocarboxylic acid namespace: chebi_ontology def: "An oxoacid containing a single carboxy group." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "monocarboxylic acid" EXACT [UniProt:] synonym: "monocarboxylic acids" RELATED [ChEBI:] is_a: CHEBI:33575 ! carboxylic acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25413 name: monounsaturated fatty acid namespace: chebi_ontology def: "Any fatty acid with one double or triple bond in the fatty acid chain and singly bonded carbon atoms in the rest of the chain. MUFAs have positive effects on the cardiovascular system, and in diabetes treatment." [] synonym: "monounsaturated fatty acids" RELATED [ChEBI:] synonym: "MUFA" RELATED [ChEBI:] synonym: "MUFAs" RELATED [ChEBI:] xref: CiteXplore:10584045 "PubMed citation" xref: CiteXplore:12936956 "PubMed citation" is_a: CHEBI:27208 ! unsaturated fatty acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25414 name: monoatomic monocation namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "[*+]" RELATED SMILES [ChEBI:] synonym: "monoatomic monocations" RELATED [ChEBI:] synonym: "monovalent cation" RELATED [UniProt:] synonym: "monovalent inorganic cations" RELATED [ChEBI:] is_a: CHEBI:23906 ! monoatomic cation property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25447 name: myo-inositol pentakisphosphate namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "myo-inositol pentakisphosphates" RELATED [ChEBI:] is_a: CHEBI:18087 ! myo-inositol polyphosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25448 name: myo-inositol phosphate namespace: chebi_ontology def: "An inositol phosphate in which the inositol component has myo-configuration." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "myo inositol phosphates" RELATED [ChEBI:] synonym: "myo-inositol phosphate" EXACT [ChEBI:] synonym: "myo-inositol phosphates" RELATED [ChEBI:] xref: CiteXplore:1694860 "PubMed citation" is_a: CHEBI:24846 ! inositol phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25477 name: naphthalenes namespace: chebi_ontology def: "Any benzenoid aromatic compound having a skeleton composed of two ortho-fused benzene rings." [] synonym: "naphthalenes" EXACT [ChEBI:] is_a: CHEBI:33836 ! benzenoid aromatic compound is_a: CHEBI:36785 ! carbobicyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25480 name: naphthohydroquinone antibiotic namespace: chebi_ontology synonym: "naphthohydroquinone antibiotics" RELATED [ChEBI:] is_a: CHEBI:49319 ! carbocyclic antibiotic is_a: CHEBI:51475 ! naphthohydroquinone property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25481 name: naphthoquinone namespace: chebi_ontology def: "A polycyclic aromatic ketone metabolite of naphthalene." [] synonym: "naphthoquinones" RELATED [ChEBI:] is_a: CHEBI:36141 ! quinone property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25516 name: nickel cation namespace: chebi_ontology synonym: "Ni" RELATED FORMULA [ChEBI:] synonym: "Ni cation" RELATED [UniProt:] synonym: "nickel cation" EXACT IUPAC_NAME [IUPAC:] synonym: "nickel cations" RELATED [ChEBI:] is_a: CHEBI:33515 ! transition element cation is_a: CHEBI:60248 ! nickel ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25529 name: pyridinecarboxamide namespace: chebi_ontology def: "A member of the class of pyridines that is a substituted pyridine in which at least one of the substituents is a carboxamide or N-substituted caraboxamide group." [] synonym: "pyridinecarboxamides" RELATED [ChEBI:] is_a: CHEBI:26421 ! pyridines is_a: CHEBI:37622 ! carboxamide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25558 name: organonitrogen heterocyclic antibiotic namespace: chebi_ontology synonym: "nitrogenous heterocyclic antibiotics" RELATED [ChEBI:] synonym: "organonitrogen heterocyclic antibiotics" RELATED [ChEBI:] is_a: CHEBI:24531 ! heterocyclic antibiotic is_a: CHEBI:38101 ! organonitrogen heterocyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25608 name: nucleoside phosphate namespace: chebi_ontology def: "A nucleobase-containing molecular entity that is a nucleoside in which one or more of the sugar hydroxy groups has been converted into a mono- or poly-phosphate. The term includes both nucleotides and non-nucleotide nucleoside phosphates." [] synonym: "NMP" RELATED [KEGG COMPOUND:] synonym: "Nucleoside monophosphate" RELATED [KEGG COMPOUND:] synonym: "nucleoside phosphates" RELATED [ChEBI:] synonym: "O[C@H]1[C@H]([*])O[C@H](COP(O)(O)=O)[C@H]1O" RELATED SMILES [ChEBI:] xref: ChEBI:C03013 "KEGG COMPOUND" xref: KEGG COMPOUND:C01329 "KEGG COMPOUND" is_a: CHEBI:25703 ! organic phosphate is_a: CHEBI:37734 ! phosphoric ester is_a: CHEBI:61120 ! nucleobase-containing molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25675 name: oligomycin namespace: chebi_ontology def: "Any of the 26-membered ring macrolides produced by Streptomyces species that can be toxic to other organisms through their ability to inhibit mitochondrial membrane-bound ATP synthases." [] synonym: "oligomycins" RELATED [ChEBI:] xref: Wikipedia:Oligomycin "Wikipedia" is_a: CHEBI:25105 ! macrolide antibiotic property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25676 name: oligopeptide namespace: chebi_ontology alt_id: CHEBI:7755 synonym: "C2H4NO2R(C2H2NOR)n" RELATED FORMULA [KEGG COMPOUND:] synonym: "Oligopeptid" RELATED [ChEBI:] synonym: "Oligopeptide" EXACT [KEGG COMPOUND:] synonym: "oligopeptides" EXACT IUPAC_NAME [IUPAC:] synonym: "oligopeptides" RELATED [ChEBI:] synonym: "oligopeptido" RELATED [ChEBI:] xref: KEGG COMPOUND:C00098 "KEGG COMPOUND" is_a: CHEBI:16670 ! peptide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25693 name: organic heteromonocyclic compound namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "one-ring heterocyclic compounds" RELATED [ChEBI:] synonym: "organic heteromonocyclic compounds" RELATED [ChEBI:] is_a: CHEBI:24532 ! organic heterocyclic compound is_a: CHEBI:33670 ! heteromonocyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25696 name: organic anion namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "organic anions" RELATED [ChEBI:] is_a: CHEBI:22563 ! anion is_a: CHEBI:25699 ! organic ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25697 name: organic cation namespace: chebi_ontology def: "Any organic ion with a net positive charge." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "organic cations" RELATED [ChEBI:] is_a: CHEBI:25699 ! organic ion is_a: CHEBI:36916 ! cation property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25698 name: ether namespace: chebi_ontology def: "An organooxygen compound with formula ROR, where R is not hydrogen." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "[*]O[*]" RELATED SMILES [ChEBI:] synonym: "ether" EXACT IUPAC_NAME [IUPAC:] synonym: "ethers" EXACT IUPAC_NAME [IUPAC:] synonym: "ethers" RELATED [ChEBI:] synonym: "OR2" RELATED FORMULA [ChEBI:] is_a: CHEBI:36963 ! organooxygen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25699 name: organic ion namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "organic ions" RELATED [ChEBI:] is_a: CHEBI:24870 ! ion is_a: CHEBI:50860 ! organic molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25703 name: organic phosphate namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "organic phosphate" EXACT [ChEBI:] synonym: "organic phosphate ester" RELATED [ChEBI:] synonym: "organic phosphate esters" RELATED [ChEBI:] synonym: "organic phosphates" RELATED [ChEBI:] synonym: "organophosphate ester" RELATED [ChEBI:] synonym: "organophosphate esters" RELATED [ChEBI:] is_a: CHEBI:25710 ! organophosphorus compound is_a: CHEBI:26020 ! phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25704 name: organic sulfate namespace: chebi_ontology def: "Compounds of the general formula SO3HOR where R is an organyl group" [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "organic sulfates" RELATED [ChEBI:] is_a: CHEBI:26820 ! sulfates is_a: CHEBI:33261 ! organosulfur compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25707 name: organometallic compound namespace: chebi_ontology def: "A compound having bonds between one or more metal atoms and one or more carbon atoms of an organyl group." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "metalloorganic compounds" RELATED [ChEBI:] synonym: "metalloorganics" RELATED [ChEBI:] synonym: "metalorganic compounds" RELATED [ChEBI:] synonym: "organometallic compounds" EXACT IUPAC_NAME [IUPAC:] synonym: "organometallics" RELATED [ChEBI:] is_a: CHEBI:50860 ! organic molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:2571 name: aliphatic alcohol namespace: chebi_ontology def: "An alcohol derived from an aliphatic compound." [] synonym: "Aliphatic alcohol" EXACT [KEGG COMPOUND:] synonym: "aliphatic alcohol" EXACT [UniProt:] synonym: "aliphatic alcohols" RELATED [ChEBI:] synonym: "HOR" RELATED FORMULA [KEGG COMPOUND:] synonym: "O[*]" RELATED SMILES [ChEBI:] xref: KEGG COMPOUND:C02525 "KEGG COMPOUND" is_a: CHEBI:30879 ! alcohol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25710 name: organophosphorus compound namespace: chebi_ontology def: "An organophosphorus compound is formally a compound containing at least one carbon-phosphorus bond, but the term is often extended to include esters and thioesters." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "organophosphorus compound" EXACT [ChEBI:] synonym: "organophosphorus compounds" RELATED [ChEBI:] is_a: CHEBI:26082 ! phosphorus molecular entity is_a: CHEBI:33285 ! heteroorganic entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25712 name: organoselenium compound namespace: chebi_ontology def: "An organoselenium compound is a compound containing at least one carbon-selenium bond." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "organoselenium compound" EXACT [ChEBI:] synonym: "organoselenium compounds" RELATED [ChEBI:] is_a: CHEBI:26628 ! selenium molecular entity is_a: CHEBI:36962 ! organochalcogen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25717 name: organotin compound namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "organotin compounds" RELATED [ChEBI:] synonym: "stannanes" RELATED [ChEBI:] is_a: CHEBI:25707 ! organometallic compound is_a: CHEBI:27008 ! tin molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25722 name: orotidine namespace: chebi_ontology def: "A nucleoside formed by attaching orotic acid to a ribose ring via a beta-N(1)-glycosidic bond." [] synonym: "1,2,3,6-tetrahydro2,6-dioxo-3beta-D-ribofuranosyl-4-pyrimidinecarboxylic acid" RELATED [ChEBI:] synonym: "3-Ribofuranosylorotic acid" RELATED [ChemIDplus:] synonym: "6-Carboxyuridine" RELATED [ChemIDplus:] synonym: "6-carboxyuridine" RELATED [ChEBI:] synonym: "C10H12N2O8" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C10H12N2O8/c13-2-4-6(15)7(16)8(20-4)12-3(9(17)18)1-5(14)11-10(12)19/h1,4,6-8,13,15-16H,2H2,(H,17,18)(H,11,14,19)/t4-,6-,7-,8-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=FKCRAVPPBFWEJD-XVFCMESISA-N" RELATED InChIKey [ChEBI:] synonym: "OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1c(cc(=O)[nH]c1=O)C(O)=O" RELATED SMILES [ChEBI:] synonym: "orotidine" EXACT [ChEBI:] xref: ChemIDplus:314-50-1 "CAS Registry Number" xref: CiteXplore:14853953 "PubMed citation" xref: CiteXplore:23555823 "PubMed citation" xref: Reaxys:47461 "Reaxys Registry Number" is_a: CHEBI:26447 ! pyrimidinemonocarboxylic acid is_a: CHEBI:27242 ! uridines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25741 name: oxide namespace: chebi_ontology def: "An oxide is a chemical compound of oxygen with other chemical elements." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "oxide" EXACT [ChEBI:] synonym: "oxides" RELATED [ChEBI:] is_a: CHEBI:25806 ! oxygen molecular entity is_a: CHEBI:37577 ! heteroatomic molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25754 name: oxo carboxylic acid namespace: chebi_ontology def: "Any compound that has an aldehydic or ketonic group as well as a carboxylic acid group in the same molecule." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "oxo acids" RELATED [IUPAC:] synonym: "oxo carboxylic acids" EXACT IUPAC_NAME [IUPAC:] synonym: "oxo carboxylic acids" RELATED [ChEBI:] is_a: CHEBI:33575 ! carboxylic acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25806 name: oxygen molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "oxygen compounds" RELATED [ChEBI:] synonym: "oxygen molecular entities" RELATED [ChEBI:] synonym: "oxygen molecular entity" EXACT [ChEBI:] is_a: CHEBI:33304 ! chalcogen molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25807 name: organooxygen heterocyclic antibiotic namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "organooxygen heterocyclic antibiotics" RELATED [ChEBI:] synonym: "oxygen containing heterocyclic antibiotics" RELATED [ChEBI:] is_a: CHEBI:24531 ! heterocyclic antibiotic property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25900 name: aldopentose phosphate namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "aldopentose phosphate" EXACT [ChEBI:] synonym: "aldopentose phosphates" RELATED [ChEBI:] synonym: "pentose phosphates" RELATED [ChEBI:] is_a: CHEBI:35131 ! aldose phosphate is_a: CHEBI:84055 ! pentose phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25903 name: peptide antibiotic namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "peptide antibiotics" RELATED [ChEBI:] is_a: CHEBI:16670 ! peptide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25905 name: peptide hormone namespace: chebi_ontology def: "Any peptide with hormonal activity in animals, whether endocrine, neuroendocrine, or paracrine." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "peptide hormones" RELATED [ChEBI:] synonym: "polypeptide hormone" RELATED [ChEBI:] is_a: CHEBI:16670 ! peptide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25940 name: peroxides namespace: chebi_ontology def: "Compounds of structure ROOR'." [] synonym: "[*]OO[*]" RELATED SMILES [ChEBI:] synonym: "a peroxide" RELATED [UniProt:] synonym: "O2R2" RELATED FORMULA [ChEBI:] synonym: "peroxides" EXACT [ChEBI:] is_a: CHEBI:25741 ! oxide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:25985 name: phenylalanine derivative namespace: chebi_ontology def: "An amino acid derivative resulting from reaction of alanine at the amino group or the carboxy group, or from the replacement of any hydrogen of phenylalanine by a heteroatom. The definition normally excludes peptides containing phenylalanine residues." [] synonym: "phenylalanine derivatives" RELATED [ChEBI:] is_a: CHEBI:83821 ! amino acid derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26020 name: phosphate namespace: chebi_ontology def: "Salts and esters of phosphoric and oligophosphoric acids and their chalcogen analogues. In inorganic chemistry, the term is also used to describe anionic coordination entities with phosphorus as central atom." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "phosphates" EXACT IUPAC_NAME [IUPAC:] synonym: "phosphates" RELATED [ChEBI:] is_a: CHEBI:26079 ! phosphoric acid derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26034 name: phosphatidylinositol 3-phosphate namespace: chebi_ontology def: "A phosphatidylinositol monophosphate carrying the phosphate group at the 3-position." [] synonym: "phosphatidylinositol 3-phosphates" RELATED [ChEBI:] synonym: "PI(3)P" RELATED [ChEBI:] synonym: "PtdIns3P" RELATED [ChEBI:] xref: ChEBI:C04139 "KEGG COMPOUND" xref: CiteXplore:18927492 "PubMed citation" is_a: CHEBI:26036 ! phosphatidylinositol monophosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26036 name: phosphatidylinositol monophosphate namespace: chebi_ontology synonym: "phosphatidylinositol monophosphates" RELATED [ChEBI:] is_a: CHEBI:28765 ! phosphatidylinositol phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26079 name: phosphoric acid derivative namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "phosphoric acid derivatives" RELATED [ChEBI:] synonym: "phosphoric acids" RELATED [ChEBI:] is_a: CHEBI:36359 ! phosphorus oxoacid derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26082 name: phosphorus molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "phosphorus compounds" RELATED [ChEBI:] synonym: "phosphorus molecular entities" RELATED [ChEBI:] is_a: CHEBI:33302 ! pnictogen molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26124 name: phytosteroid namespace: chebi_ontology synonym: "phytosteroids" RELATED [ChEBI:] is_a: CHEBI:35350 ! hydroxy steroid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26125 name: phytosterols namespace: chebi_ontology def: "Sterols similar to cholesterol which occur in plants and vary only in carbon side chains and/or presence or absence of a double bond." [] xref: Wikipedia:Phytosterol "Wikipedia" is_a: CHEBI:15889 ! sterol is_a: CHEBI:26124 ! phytosteroid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26144 name: piperazines namespace: chebi_ontology synonym: "piperazines" EXACT [ChEBI:] is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26151 name: piperidines namespace: chebi_ontology synonym: "piperidines" EXACT [ChEBI:] is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26177 name: polyene antibiotic namespace: chebi_ontology def: "A family of antibiotics containing a conjugated polyene moiety, usuallly isolated from some species of Streptomyces." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "polyene antibiotics" RELATED [ChEBI:] is_a: CHEBI:33822 ! organic hydroxy compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26179 name: polyether antibiotic namespace: chebi_ontology synonym: "polyether antibiotics" RELATED [ChEBI:] is_a: CHEBI:25807 ! organooxygen heterocyclic antibiotic property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26186 name: polyprenyl phospho oligosaccharide namespace: chebi_ontology synonym: "polyisoprenyl phosphate oligosaccharides" RELATED [ChEBI:] synonym: "polyprenyl phospho oligosaccharides" RELATED [ChEBI:] is_a: CHEBI:16916 ! oligosaccharide phosphate is_a: CHEBI:26187 ! polyprenyl phospho carbohydrate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26187 name: polyprenyl phospho carbohydrate namespace: chebi_ontology synonym: "polyisoprenyl phosphate sugars" RELATED [ChEBI:] synonym: "polyprenyl phospho carbohydrates" RELATED [ChEBI:] is_a: CHEBI:16460 ! polyprenol phosphate is_a: CHEBI:24397 ! glycophospholipid is_a: CHEBI:26816 ! carbohydrate phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26188 name: polyketide namespace: chebi_ontology def: "Natural and synthetic compounds containing alternating carbonyl and methylene groups ('beta-polyketones'), biogenetically derived from repeated condensation of acetyl coenzyme A (via malonyl coenzyme A), and usually the compounds derived from them by further condensations. Considered by many to be synonymous with the less frequently used terms acetogenins and ketides." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "polyketide" EXACT [ChEBI:] synonym: "polyketides" RELATED [ChEBI:] is_a: CHEBI:36963 ! organooxygen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26191 name: polyol namespace: chebi_ontology def: "A compound that contains two or more hydroxy groups." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "polyols" RELATED [ChEBI:] is_a: CHEBI:33822 ! organic hydroxy compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26195 name: polyphenol namespace: chebi_ontology def: "Members of the class of phenols that contain 2 or more benzene rings each of which is substituted by at least one hydroxy group." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "polyphenols" RELATED [ChEBI:] xref: Wikipedia:Polyphenol "Wikipedia" is_a: CHEBI:33853 ! phenols property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26208 name: polyunsaturated fatty acid namespace: chebi_ontology def: "Any fatty acid containing more than one double bond. Acids in this group are reported to have cardioprotective effects; and levels are lowered in chronic fatigue syndrome." [] synonym: "polyunsaturated fatty acids" RELATED [ChEBI:] synonym: "PUFA" RELATED [ChEBI:] synonym: "PUFAs" RELATED [ChEBI:] xref: CiteXplore:14977874 "PubMed citation" xref: CiteXplore:16380690 "PubMed citation" xref: CiteXplore:17891522 "PubMed citation" is_a: CHEBI:27208 ! unsaturated fatty acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26217 name: potassium molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "potassium compounds" RELATED [ChEBI:] synonym: "potassium molecular entities" RELATED [ChEBI:] synonym: "potassium molecular entity" EXACT [ChEBI:] is_a: CHEBI:33296 ! alkali metal molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26218 name: potassium salt namespace: chebi_ontology def: "Any alkali metal salt having potassium(1+) as the cation." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "Kaliumsalz" RELATED [ChEBI:] synonym: "Kaliumsalze" RELATED [ChEBI:] synonym: "potassium salts" RELATED [ChEBI:] is_a: CHEBI:26217 ! potassium molecular entity is_a: CHEBI:35479 ! alkali metal salt property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26250 name: prenol phosphate namespace: chebi_ontology synonym: "prenol phosphates" RELATED [ChEBI:] synonym: "prenyl phosphates" RELATED [ChEBI:] is_a: CHEBI:37841 ! isoprenoid phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26255 name: prenylquinone namespace: chebi_ontology alt_id: CHEBI:72751 def: "A quinone substituted by a polyprenyl-derived side-chain. Prenylquinones occur in all living cells. Due to their amphiphilic character, they are mainly located in biological membranes where they function as electron and proton carriers in the photosynthetic and respiratory electron transport chains. Some prenylquinones also perform more specialised roles sucy as antioxidants and enzyme cofactors. Prenylquinones are classified according to ring structure: the main classes are menaquinones, phylloquinones, ubiquinones and plastoquinones." [] synonym: "polyprenylquinone" RELATED [ChEBI:] synonym: "polyprenylquinones" RELATED [ChEBI:] synonym: "prenylquinones" RELATED [ChEBI:] xref: CiteXplore:19928587 "PubMed citation" xref: CiteXplore:21777468 "PubMed citation" xref: CiteXplore:21844348 "PubMed citation" xref: CiteXplore:22371323 "PubMed citation" xref: CiteXplore:3985624 "PubMed citation" is_a: CHEBI:36141 ! quinone property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26271 name: proline namespace: chebi_ontology def: "An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2." [] synonym: "C5H9NO2" RELATED FORMULA [ChEBI:] synonym: "DL-Proline" RELATED [KEGG COMPOUND:] synonym: "Hpro" RELATED [IUPAC:] synonym: "InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)" RELATED InChI [ChEBI:] synonym: "InChIKey=ONIBWKKTOPOVIA-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "OC(=O)C1CCCN1" RELATED SMILES [ChEBI:] synonym: "Prolin" RELATED [ChEBI:] synonym: "prolina" RELATED [ChEBI:] synonym: "proline" EXACT [ChEBI:] synonym: "proline" EXACT IUPAC_NAME [IUPAC:] synonym: "pyrrolidine-2-carboxylic acid" RELATED [IUPAC:] xref: Beilstein:80809 "Beilstein Registry Number" xref: ChemIDplus:609-36-9 "CAS Registry Number" xref: CiteXplore:16534801 "PubMed citation" xref: CiteXplore:21400017 "PubMed citation" xref: CiteXplore:21903295 "PubMed citation" xref: CiteXplore:22264337 "PubMed citation" xref: CiteXplore:22280966 "PubMed citation" xref: CiteXplore:22770225 "PubMed citation" xref: Gmelin:26927 "Gmelin Registry Number" xref: KEGG COMPOUND:609-36-9 "CAS Registry Number" xref: KEGG COMPOUND:C16435 "KEGG COMPOUND" xref: NIST Chemistry WebBook:609-36-9 "CAS Registry Number" xref: Reaxys:80809 "Reaxys Registry Number" xref: Wikipedia:Proline "Wikipedia" is_a: CHEBI:33704 ! alpha-amino acid is_a: CHEBI:38260 ! pyrrolidines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26282 name: propanals namespace: chebi_ontology def: "An aldehyde based on a propanal skeleton and its derivatives." [] synonym: "propanals" EXACT [ChEBI:] is_a: CHEBI:17478 ! aldehyde property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26373 name: pteridines namespace: chebi_ontology synonym: "pteridines" EXACT [ChEBI:] is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:33833 ! heteroarene is_a: CHEBI:38101 ! organonitrogen heterocyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26385 name: purine alkaloid namespace: chebi_ontology synonym: "purine alkaloids" RELATED [ChEBI:] is_a: CHEBI:22315 ! alkaloid is_a: CHEBI:26401 ! purines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26386 name: purine nucleobase namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "purine bases" RELATED [ChEBI:] synonym: "purine nucleobase" EXACT [ChEBI:] synonym: "purine nucleobases" RELATED [ChEBI:] xref: KEGG COMPOUND:C15587 "KEGG COMPOUND" is_a: CHEBI:18282 ! nucleobase is_a: CHEBI:26401 ! purines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26389 name: purine deoxyribonucleoside triphosphate namespace: chebi_ontology synonym: "purine deoxyribonucleoside triphosphates" RELATED [ChEBI:] is_a: CHEBI:16516 ! 2'-deoxyribonucleoside triphosphate is_a: CHEBI:26393 ! purine nucleoside triphosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:2639 name: amiloride namespace: chebi_ontology alt_id: CHEBI:47210 def: "A monocarboxylic acid amide that is N-carbamimidoylpyrazine-2-carboxamide substituted by amino groups at positions 3 and 5 and a chloro group at position 6." [] synonym: "3,5-DIAMINO-N-(AMINOIMINOMETHYL)-6-CHLOROPYRAZINECARBOXAMIDE" RELATED [PDBeChem:] synonym: "3,5-diamino-N-[amino(imino)methyl]-6-chloropyrazine-2-carboxamide" EXACT IUPAC_NAME [IUPAC:] synonym: "3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide" RELATED [IUPAC:] synonym: "3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide" RELATED [PDBeChem:] synonym: "amilorida" RELATED INN [ChemIDplus:] synonym: "Amiloride" EXACT [KEGG COMPOUND:] synonym: "amiloride" RELATED INN [ChEBI:] synonym: "amiloridum" RELATED INN [ChemIDplus:] synonym: "C6H8ClN7O" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)" RELATED InChI [ChEBI:] synonym: "InChIKey=XSDQTOBWRPYKKA-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide" RELATED [ChemIDplus:] synonym: "NC(=N)NC(=O)c1nc(Cl)c(N)nc1N" RELATED SMILES [ChEBI:] xref: Beilstein:616612 "Beilstein Registry Number" xref: ChemIDplus:2609-46-3 "CAS Registry Number" xref: CiteXplore:16020936 "PubMed citation" xref: CiteXplore:24410943 "PubMed citation" xref: CiteXplore:24419567 "PubMed citation" xref: CiteXplore:9124403 "PubMed citation" xref: DrugBank:DB00594 "DrugBank" xref: HMDB:HMDB14732 "HMDB" xref: KEGG COMPOUND:2609-46-3 "CAS Registry Number" xref: KEGG COMPOUND:C06821 "KEGG COMPOUND" xref: KEGG DRUG:D07447 "KEGG DRUG" xref: Patent:BE639386 "Patent" xref: Patent:US3313813 "Patent" xref: PDBeChem:AMR "PDBeChem" xref: Reaxys:657410 "Reaxys Registry Number" xref: Wikipedia:Amiloride "Wikipedia" is_a: CHEBI:24436 ! guanidines is_a: CHEBI:29347 ! monocarboxylic acid amide is_a: CHEBI:33860 ! aromatic amine is_a: CHEBI:36683 ! organochlorine compound is_a: CHEBI:38314 ! pyrazines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26390 name: purine 2'-deoxyribonucleotide namespace: chebi_ontology synonym: "purine 2'-deoxyribonucleotides" RELATED [ChEBI:] synonym: "purine deoxyribonucleotidse" RELATED [ChEBI:] is_a: CHEBI:19260 ! 2'-deoxyribonucleotide is_a: CHEBI:26395 ! purine nucleotide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26393 name: purine nucleoside triphosphate namespace: chebi_ontology synonym: "purine nucleoside triphosphates" RELATED [ChEBI:] is_a: CHEBI:17326 ! nucleoside triphosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26394 name: purine nucleoside namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "purine nucleoside" EXACT [ChEBI:] synonym: "purine nucleosides" RELATED [ChEBI:] is_a: CHEBI:26401 ! purines is_a: CHEBI:33838 ! nucleoside property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26395 name: purine nucleotide namespace: chebi_ontology def: "Any nucleotide that has a purine nucleobase." [] synonym: "purine nucleoside phosphate" RELATED [ChEBI:] synonym: "purine nucleotides" RELATED [ChEBI:] is_a: CHEBI:26401 ! purines is_a: CHEBI:36976 ! nucleotide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26399 name: purine ribonucleoside namespace: chebi_ontology synonym: "purine ribonucleosides" RELATED [ChEBI:] is_a: CHEBI:18254 ! ribonucleoside is_a: CHEBI:26394 ! purine nucleoside property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26400 name: purine ribonucleotide namespace: chebi_ontology def: "Any ribonucleotide that has a purine nucleobase." [] synonym: "purine ribonucleotides" RELATED [ChEBI:] is_a: CHEBI:26395 ! purine nucleotide is_a: CHEBI:26561 ! ribonucleotide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26401 name: purines namespace: chebi_ontology alt_id: CHEBI:13678 def: "A class of imidazopyrimidines that consists of purine and its substituted derivatives." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "a purine" RELATED [UniProt:] is_a: CHEBI:35875 ! imidazopyrimidine property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26407 name: pyrans namespace: chebi_ontology synonym: "pyrans" EXACT [ChEBI:] is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38104 ! oxacycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26410 name: pyrazoles namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "pyrazoles" EXACT [ChEBI:] is_a: CHEBI:23677 ! diazole property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26416 name: pyridine alkaloid namespace: chebi_ontology synonym: "pyridine alkaloids" RELATED [ChEBI:] is_a: CHEBI:22315 ! alkaloid is_a: CHEBI:26421 ! pyridines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26421 name: pyridines namespace: chebi_ontology def: "Any organonitrogen heterocyclic compound based on a pyridine skeleton and its substituted derivatives." [] synonym: "pyridines" EXACT [ChEBI:] is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26432 name: pyrimidine nucleobase namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "pyrimidine bases" RELATED [ChEBI:] synonym: "pyrimidine nucleobase" EXACT [ChEBI:] synonym: "pyrimidine nucleobases" RELATED [ChEBI:] is_a: CHEBI:18282 ! nucleobase is_a: CHEBI:39447 ! pyrimidines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26433 name: pyrimidine 2'-deoxyribonucleoside diphosphate namespace: chebi_ontology synonym: "pyrimidine 2'-deoxyribonucleoside diphosphates" RELATED [ChEBI:] synonym: "pyrimidine deoxyribonucleoside diphosphates" RELATED [ChEBI:] is_a: CHEBI:17955 ! 2'-deoxyribonucleoside diphosphate is_a: CHEBI:26437 ! pyrimidine nucleoside diphosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26435 name: pyrimidine deoxyribonucleoside triphosphate namespace: chebi_ontology synonym: "pyrimidine deoxyribonucleoside triphosphates" RELATED [ChEBI:] is_a: CHEBI:16516 ! 2'-deoxyribonucleoside triphosphate is_a: CHEBI:26439 ! pyrimidine nucleoside triphosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26436 name: pyrimidine 2'-deoxyribonucleotide namespace: chebi_ontology synonym: "pyrimidine 2'-deoxyribonucleotides" RELATED [ChEBI:] synonym: "pyrimidine deoxyribonucleotides" RELATED [ChEBI:] is_a: CHEBI:19260 ! 2'-deoxyribonucleotide is_a: CHEBI:26441 ! pyrimidine nucleotide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26437 name: pyrimidine nucleoside diphosphate namespace: chebi_ontology synonym: "pyrimidine nucleoside diphosphates" RELATED [ChEBI:] is_a: CHEBI:16862 ! nucleoside diphosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26438 name: pyrimidine nucleoside monophosphate namespace: chebi_ontology synonym: "pyrimidine nucleoside monophosphates" RELATED [ChEBI:] is_a: CHEBI:17188 ! nucleoside monophosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26439 name: pyrimidine nucleoside triphosphate namespace: chebi_ontology synonym: "pyrimidine nucleoside triphosphates" RELATED [ChEBI:] is_a: CHEBI:17326 ! nucleoside triphosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26440 name: pyrimidine nucleoside namespace: chebi_ontology synonym: "N-D-Ribosylpyrimidine" RELATED [KEGG COMPOUND:] synonym: "pyrimidine nucleosides" RELATED [ChEBI:] xref: KEGG COMPOUND:C03169 "KEGG COMPOUND" is_a: CHEBI:33838 ! nucleoside is_a: CHEBI:39447 ! pyrimidines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26441 name: pyrimidine nucleotide namespace: chebi_ontology synonym: "pyrimidine nucleoside phosphate" RELATED [ChEBI:] synonym: "pyrimidine nucleotides" RELATED [ChEBI:] xref: ChEBI:C03169 "KEGG COMPOUND" is_a: CHEBI:36976 ! nucleotide is_a: CHEBI:39447 ! pyrimidines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26443 name: pyrimidine ribonucleoside monophosphate namespace: chebi_ontology synonym: "pyrimidine ribonucleoside monophosphates" RELATED [ChEBI:] is_a: CHEBI:26438 ! pyrimidine nucleoside monophosphate is_a: CHEBI:26558 ! ribonucleoside monophosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26446 name: pyrimidine ribonucleotide namespace: chebi_ontology synonym: "pyrimidine ribonucleotides" RELATED [ChEBI:] is_a: CHEBI:26441 ! pyrimidine nucleotide is_a: CHEBI:26561 ! ribonucleotide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26447 name: pyrimidinemonocarboxylic acid namespace: chebi_ontology synonym: "pyrimidinecarboxylic acids" RELATED [ChEBI:] synonym: "pyrimidinemonocarboxylic acids" RELATED [ChEBI:] is_a: CHEBI:25384 ! monocarboxylic acid is_a: CHEBI:78574 ! pyrimidinecarboxylic acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26463 name: pyruvate family amino acid namespace: chebi_ontology def: "An L-alpha-amino acid which is biosynthesised from pyruvate (i.e. alanine, valine, and leucine). A closed class." [] synonym: "pyruvate family amino acids" RELATED [ChEBI:] is_a: CHEBI:15705 ! L-alpha-amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26469 name: quaternary nitrogen compound namespace: chebi_ontology def: "A nitrogen molecular entity that is electronically neutral but which contains a quaternary nitrogen." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "quaternary nitrogen compounds" RELATED [ChEBI:] is_a: CHEBI:51143 ! nitrogen molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26508 name: quinoline N-oxide namespace: chebi_ontology synonym: "quinoline N-oxides" RELATED [ChEBI:] is_a: CHEBI:26513 ! quinolines is_a: CHEBI:35580 ! N-oxide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26509 name: quinoline alkaloid namespace: chebi_ontology synonym: "quinoline alkaloids" RELATED [ChEBI:] is_a: CHEBI:22315 ! alkaloid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26513 name: quinolines namespace: chebi_ontology def: "A class of aromatic heterocyclic compounds each of which contains a benzene ring ortho fused to carbons 2 and 3 of a pyridine ring." [] synonym: "quinolines" EXACT [ChEBI:] xref: ChEBI:C06413 "KEGG COMPOUND" is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:33659 ! organic aromatic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26519 name: radical namespace: chebi_ontology def: "A molecular entity possessing an unpaired electron." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "free radical" RELATED [ChEBI:] synonym: "freies Radikal" RELATED [ChEBI:] synonym: "radical" EXACT IUPAC_NAME [IUPAC:] synonym: "radical libre" RELATED [ChEBI:] synonym: "radicales libres" RELATED [ChEBI:] synonym: "radicals" RELATED [IUPAC:] synonym: "Radikal" RELATED [ChEBI:] synonym: "Radikale" RELATED [ChEBI:] is_a: CHEBI:23367 ! molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26523 name: reactive oxygen species namespace: chebi_ontology def: "Molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "ROS" RELATED [ChEBI:] xref: Wikipedia:Reactive_oxygen_species "Wikipedia" is_a: CHEBI:25806 ! oxygen molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26558 name: ribonucleoside monophosphate namespace: chebi_ontology synonym: "ribonucleoside monophosphates" RELATED [ChEBI:] is_a: CHEBI:17188 ! nucleoside monophosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26561 name: ribonucleotide namespace: chebi_ontology synonym: "ribonucleotides" RELATED [ChEBI:] is_a: CHEBI:26562 ! ribose phosphate is_a: CHEBI:36976 ! nucleotide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26562 name: ribose phosphate namespace: chebi_ontology synonym: "ribose phosphate" EXACT [ChEBI:] synonym: "ribose phosphates" RELATED [ChEBI:] is_a: CHEBI:25900 ! aldopentose phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26588 name: 1,3,5-triazines namespace: chebi_ontology def: "Any compound with a 1,3,5-triazine skeleton, in which nitrogen atoms replace carbon at positions 1, 3 and 5 of the core benzene ring structure." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "s-triazines" RELATED [ChEBI:] is_a: CHEBI:38102 ! triazines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26605 name: saponin namespace: chebi_ontology alt_id: CHEBI:60583 def: "A glycoside that is a compound containing one or more hydrophilic glycoside moieties combined with a lipophilic triterpenoid or steroid derivative. Found in particular abundance in plant species." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "sapogenin glycoside" RELATED [ChEBI:] synonym: "sapogenin glycosides" RELATED [ChEBI:] synonym: "saponins" RELATED [ChEBI:] is_a: CHEBI:24400 ! glycoside property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26607 name: saturated fatty acid namespace: chebi_ontology def: "Any fatty acid containing no carbon to carbon multiple bonds. Known to produce adverse biological effects when ingested to excess." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "saturated fatty acid" EXACT [ChEBI:] synonym: "saturated fatty acids" RELATED [ChEBI:] synonym: "SFA" RELATED [ChEBI:] synonym: "SFAs" RELATED [ChEBI:] xref: CiteXplore:16492686 "PubMed citation" xref: CiteXplore:19763019 "PubMed citation" xref: CiteXplore:20237329 "PubMed citation" is_a: CHEBI:35366 ! fatty acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26628 name: selenium molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "selenium compounds" RELATED [ChEBI:] synonym: "selenium molecular entities" RELATED [ChEBI:] synonym: "selenium molecular entity" EXACT [ChEBI:] is_a: CHEBI:33304 ! chalcogen molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26629 name: selenoamino acid namespace: chebi_ontology synonym: "selenoamino acids" RELATED [ChEBI:] is_a: CHEBI:25712 ! organoselenium compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:2663 name: amiodarone namespace: chebi_ontology def: "A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias." [] synonym: "(2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone" EXACT IUPAC_NAME [IUPAC:] synonym: "2-Butyl-3-(3,5-diiodo-4-(2-diethylaminoethoxy)benzoyl)benzofuran" RELATED [ChemIDplus:] synonym: "2-Butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl ketone" RELATED [ChemIDplus:] synonym: "2-n-Butyl-3',5'-diiodo-4'-N-diethylaminoethoxy-3-benzoylbenzofuran" RELATED [ChemIDplus:] synonym: "amiodarona" RELATED INN [ChemIDplus:] synonym: "Amiodarone" EXACT [KEGG COMPOUND:] synonym: "amiodaronum" RELATED INN [ChemIDplus:] synonym: "C25H29I2NO3" RELATED FORMULA [ChEBI:] synonym: "CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN(CC)CC)c(I)c1" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C25H29I2NO3/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3" RELATED InChI [ChEBI:] synonym: "InChIKey=IYIKLHRQXLHMJQ-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] xref: Beilstein:1271711 "Beilstein Registry Number" xref: ChemIDplus:1951-25-3 "CAS Registry Number" xref: CiteXplore:10188629 "PubMed citation" xref: CiteXplore:16479044 "PubMed citation" xref: CiteXplore:18368867 "PubMed citation" xref: DrugBank:DB01118 "DrugBank" xref: HMDB:HMDB15250 "HMDB" xref: KEGG COMPOUND:1951-25-3 "CAS Registry Number" xref: KEGG COMPOUND:C06823 "KEGG COMPOUND" xref: KEGG DRUG:D02910 "KEGG DRUG" xref: Patent:CA2826272 "Patent" xref: Patent:TW201400111 "Patent" xref: Wikipedia:Amiodarone "Wikipedia" is_a: CHEBI:37142 ! organoiodine compound is_a: CHEBI:38830 ! 1-benzofurans is_a: CHEBI:50996 ! tertiary amino compound is_a: CHEBI:76224 ! aromatic ketone property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26649 name: serine derivative namespace: chebi_ontology def: "An amino acid derivative resulting from reaction of serine at the amino group or the carboxy group, or from the replacement of any hydrogen of serine by a heteroatom. The definition normally excludes peptides containing serine residues." [] synonym: "serine derivatives" RELATED [ChEBI:] is_a: CHEBI:83821 ! amino acid derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26650 name: serine family amino acid namespace: chebi_ontology def: "An L-alpha-amino acid which is biosynthesised from 3-phosphoglycerate (i.e. serine, glycine, cysteine and homocysteine). A closed class." [] synonym: "3-phosphoglycerate family amino acid" RELATED [ChEBI:] synonym: "3-phosphoglycerate family amino acids" RELATED [ChEBI:] synonym: "serine family amino acids" RELATED [ChEBI:] xref: CiteXplore:20709681 "PubMed citation" is_a: CHEBI:15705 ! L-alpha-amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26677 name: silicon molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "silicon compounds" RELATED [ChEBI:] synonym: "silicon molecular entities" RELATED [ChEBI:] synonym: "silicon molecular entity" EXACT [ChEBI:] is_a: CHEBI:33582 ! carbon group molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26712 name: sodium molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "sodium compounds" RELATED [ChEBI:] synonym: "sodium molecular entities" RELATED [ChEBI:] is_a: CHEBI:33296 ! alkali metal molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26714 name: sodium salt namespace: chebi_ontology def: "Any alkali metal salt having sodium(1+) as the cation." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "Natriumsalz" RELATED [ChEBI:] synonym: "Natriumsalze" RELATED [ChEBI:] synonym: "sodium salts" RELATED [ChEBI:] is_a: CHEBI:26712 ! sodium molecular entity is_a: CHEBI:35479 ! alkali metal salt property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26739 name: sphingolipid namespace: chebi_ontology def: "Sphingolipids are a complex family of compounds that share a common structural feature, a sphingoid base backbone." [] synonym: "sphingolipids" RELATED [ChEBI:] is_a: CHEBI:18059 ! lipid is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:36963 ! organooxygen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26789 name: streptothricin namespace: chebi_ontology def: "An N-glycosyl compound consisting of 2-amino-4-O-carbamoyl-2-deoxy-N-[(3aS,7R,7aS)-7-hydroxy-4-oxooctahydro-2H-imidazo[4,5-c]pyridin-2-ylidene]-beta-D-gulopyranosylamine in which the amino group at position 2 of the gulopyranosyl moiety is acylated by a peptide unit made up of between 1 and 7 N(epsilon)-linked units of beta-lysine." [] synonym: "C19H34N8O8" RELATED FORMULA [ChEBI:] synonym: "racemomycins" RELATED [ChEBI:] synonym: "streptothricin" EXACT [ChEBI:] synonym: "streptothricins" RELATED [ChEBI:] synonym: "yazumycins" RELATED [ChEBI:] is_a: CHEBI:21731 ! N-glycosyl compound is_a: CHEBI:23003 ! carbamate ester is_a: CHEBI:24436 ! guanidines is_a: CHEBI:24995 ! lactam is_a: CHEBI:37622 ! carboxamide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26816 name: carbohydrate phosphate namespace: chebi_ontology synonym: "carbohydrate phosphates" RELATED [ChEBI:] synonym: "sugar phosphates" RELATED [ChEBI:] xref: ChEBI:C00934 "KEGG COMPOUND" is_a: CHEBI:25703 ! organic phosphate is_a: CHEBI:37734 ! phosphoric ester is_a: CHEBI:63299 ! carbohydrate derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26819 name: sulfuric ester namespace: chebi_ontology def: "An ester of an alcohol and sulfuric acid." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "[*]OS(=O)(=O)O[*]" RELATED SMILES [ChEBI:] synonym: "O4SR2" RELATED FORMULA [ChEBI:] synonym: "sulfate ester" RELATED [ChEBI:] synonym: "sulfate esters" RELATED [ChEBI:] synonym: "sulfuric acid ester" RELATED [ChEBI:] synonym: "sulfuric acid esters" RELATED [ChEBI:] synonym: "sulfuric esters" RELATED [ChEBI:] is_a: CHEBI:35701 ! ester is_a: CHEBI:37826 ! sulfuric acid derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:2682 name: amphotericin B namespace: chebi_ontology alt_id: CHEBI:106303 alt_id: CHEBI:566395 def: "A macrolide antibiotic used to treat potentially life-threatening fungal infections." [] synonym: "(1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-amino-3,6-dideoxy-beta-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "[H][C@]12C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\\C=C\\C=C\\C=C\\C=C\\C=C\\C=C\\C=C\\[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]1C(O)=O)O2" RELATED SMILES [ChEBI:] synonym: "amfotericina B" RELATED INN [ChemIDplus:] synonym: "AMPH-B" RELATED [DrugBank:] synonym: "amphotericin B" RELATED INN [KEGG DRUG:] synonym: "Amphotericine B" RELATED [DrugBank:] synonym: "amphotericine B" RELATED INN [ChemIDplus:] synonym: "amphotericinum B" RELATED INN [ChemIDplus:] synonym: "C47H73NO17" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=APKFDSVGJQXUKY-INPOYWNPSA-N" RELATED InChIKey [ChEBI:] synonym: "Liposomal Amphotericin B" RELATED [DrugBank:] xref: Beilstein:4645978 "Beilstein Registry Number" xref: ChEMBL:16297620 "PubMed citation" xref: ChEMBL:16403624 "PubMed citation" xref: ChEMBL:16730982 "PubMed citation" xref: ChEMBL:16879965 "PubMed citation" xref: ChEMBL:16884300 "PubMed citation" xref: ChEMBL:17043122 "PubMed citation" xref: ChEMBL:17049253 "PubMed citation" xref: ChEMBL:17049255 "PubMed citation" xref: ChEMBL:17079152 "PubMed citation" xref: ChEMBL:17084633 "PubMed citation" xref: ChEMBL:17101671 "PubMed citation" xref: ChEMBL:17116665 "PubMed citation" xref: ChEMBL:17134906 "PubMed citation" xref: ChEMBL:17156894 "PubMed citation" xref: ChEMBL:17158937 "PubMed citation" xref: ChEMBL:17158939 "PubMed citation" xref: ChEMBL:17181171 "PubMed citation" xref: ChEMBL:17194821 "PubMed citation" xref: ChEMBL:17307977 "PubMed citation" xref: ChEMBL:17315962 "PubMed citation" xref: ChEMBL:1732516 "PubMed citation" xref: ChEMBL:17325226 "PubMed citation" xref: ChEMBL:17339374 "PubMed citation" xref: ChEMBL:17371828 "PubMed citation" xref: ChEMBL:17383187 "PubMed citation" xref: ChEMBL:17387150 "PubMed citation" xref: ChEMBL:17480099 "PubMed citation" xref: ChEMBL:17482460 "PubMed citation" xref: ChEMBL:17507115 "PubMed citation" xref: ChEMBL:17532639 "PubMed citation" xref: ChEMBL:17588934 "PubMed citation" xref: ChEMBL:17962024 "PubMed citation" xref: ChEMBL:17976995 "PubMed citation" xref: ChEMBL:17981473 "PubMed citation" xref: ChEMBL:18313934 "PubMed citation" xref: ChemIDplus:1397-89-3 "CAS Registry Number" xref: CiteXplore:11429202 "PubMed citation" xref: CiteXplore:16120633 "PubMed citation" xref: CiteXplore:16793999 "PubMed citation" xref: DrugBank:1397-89-3 "CAS Registry Number" xref: DrugBank:DB00681 "DrugBank" xref: KEGG COMPOUND:1397-89-3 "CAS Registry Number" xref: KEGG COMPOUND:C06573 "KEGG COMPOUND" xref: KEGG DRUG:1397-89-3 "CAS Registry Number" xref: KEGG DRUG:D00203 "KEGG DRUG" xref: LIPID MAPS:LMPK06000002 "LIPID MAPS instance" xref: Patent:US2908611 "Patent" xref: Reaxys:4645978 "Reaxys Registry Number" xref: Wikipedia:Amphotericin_B "Wikipedia" is_a: CHEBI:25105 ! macrolide antibiotic is_a: CHEBI:26177 ! polyene antibiotic property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26820 name: sulfates namespace: chebi_ontology def: "Salts and esters of sulfuric acid" [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "sulfates" EXACT [ChEBI:] synonym: "sulfuric acid derivative" RELATED [ChEBI:] synonym: "sulphates" RELATED [ChEBI:] is_a: CHEBI:37826 ! sulfuric acid derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26822 name: sulfide namespace: chebi_ontology def: "Any sulfur molecular entity that involves either covalently bonded or anionic sulfur." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "sulfides" RELATED [ChEBI:] synonym: "sulphides" RELATED [ChEBI:] is_a: CHEBI:26835 ! sulfur molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26830 name: sulfonium compound namespace: chebi_ontology synonym: "sulfonium compounds" RELATED [ChEBI:] is_a: CHEBI:26835 ! sulfur molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26834 name: sulfur-containing amino acid namespace: chebi_ontology synonym: "sulfur amino acids" RELATED [ChEBI:] synonym: "sulfur-containing amino acids" RELATED [ChEBI:] is_a: CHEBI:33576 ! sulfur-containing carboxylic acid is_a: CHEBI:33709 ! amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26835 name: sulfur molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "sulfur compounds" RELATED [ChEBI:] synonym: "sulfur molecular entities" RELATED [ChEBI:] synonym: "sulfur molecular entity" EXACT [ChEBI:] is_a: CHEBI:33304 ! chalcogen molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26873 name: terpenoid namespace: chebi_ontology def: "Any isoprenoid that is a natural product or related compound formally derived from isoprene units. Terpenoids may contain oxygen in various functional groups. This class is subdivided according to the number of carbon atoms in the parent terpene. The skeleton of terpenoids may differ from strict additivity of isoprene units by the loss or shift of a fragment, generally a methyl group." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "Terpenoid" EXACT [ChEBI:] synonym: "terpenoide" RELATED [IUPAC:] synonym: "terpenoides" RELATED [IUPAC:] synonym: "terpenoids" EXACT IUPAC_NAME [IUPAC:] xref: Wikipedia:Terpenoid "Wikipedia" is_a: CHEBI:24913 ! isoprenoid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26875 name: terpenyl phosphate namespace: chebi_ontology synonym: "terpenyl phosphates" RELATED [ChEBI:] is_a: CHEBI:26873 ! terpenoid is_a: CHEBI:37841 ! isoprenoid phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26878 name: tertiary alcohol namespace: chebi_ontology def: "A tertiary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has three other carbon atoms attached to it." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "C4H7OR3" RELATED FORMULA [ChEBI:] synonym: "OC(C[*])(C[*])C[*]" RELATED SMILES [ChEBI:] synonym: "tertiary alcohol" EXACT [ChEBI:] synonym: "tertiary alcohols" RELATED [ChEBI:] is_a: CHEBI:30879 ! alcohol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26893 name: tetracyclic triterpenoid namespace: chebi_ontology synonym: "tetracyclic triterpenoids" RELATED [ChEBI:] synonym: "tetracyclic triterpinoids" RELATED [ChEBI:] is_a: CHEBI:36615 ! triterpenoid is_a: CHEBI:51958 ! organic polycyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26895 name: tetracyclines namespace: chebi_ontology def: "A subclass of polyketides having an octahydrotetracene-2-carboxamide skeleton, substituted with many hydroxy and other groups." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "tetracyclines" EXACT [ChEBI:] is_a: CHEBI:25480 ! naphthohydroquinone antibiotic is_a: CHEBI:26188 ! polyketide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26912 name: oxolanes namespace: chebi_ontology def: "Any oxacycle having an oxolane (tetrahydrofuran) skeleton." [] synonym: "tetrahydrofurans" RELATED [ChEBI:] is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38104 ! oxacycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26948 name: thiamine namespace: chebi_ontology synonym: "thiamines" RELATED [ChEBI:] synonym: "thiamins" RELATED [ChEBI:] is_a: CHEBI:38338 ! aminopyrimidine is_a: CHEBI:38418 ! 1,3-thiazole property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26953 name: thioadenosine namespace: chebi_ontology synonym: "thioadenosines" RELATED [ChEBI:] is_a: CHEBI:22260 ! adenosines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26961 name: thiophenes namespace: chebi_ontology def: "Compounds containing at least one thiophene ring." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "thiofurans" RELATED [ChEBI:] synonym: "thiophenes" EXACT [ChEBI:] is_a: CHEBI:38106 ! organosulfur heterocyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26979 name: organic heterotricyclic compound namespace: chebi_ontology def: "An organic tricyclic compound in which at least one of the rings of the tricyclic skeleton contains one or more heteroatoms." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "heterotricyclic compounds" RELATED [ChEBI:] synonym: "organic heterotricyclic compounds" RELATED [ChEBI:] is_a: CHEBI:36688 ! heterotricyclic compound is_a: CHEBI:38166 ! organic heteropolycyclic compound is_a: CHEBI:51959 ! organic tricyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:26986 name: threonine namespace: chebi_ontology def: "An alpha-amino acid in which one of the hydrogens attached to the alpha-carbon of glycine is substituted by a 1-hydroxyethyl group." [] synonym: "C4H9NO3" RELATED FORMULA [ChEBI:] synonym: "Threonin" RELATED [ChEBI:] synonym: "threonine" EXACT IUPAC_NAME [IUPAC:] xref: Beilstein:8204750 "Beilstein Registry Number" xref: ChemIDplus:80-68-2 "CAS Registry Number" xref: CiteXplore:11379295 "PubMed citation" xref: CiteXplore:15221503 "PubMed citation" xref: CiteXplore:22264337 "PubMed citation" xref: NIST Chemistry WebBook:80-68-2 "CAS Registry Number" xref: Wikipedia:Threonine "Wikipedia" is_a: CHEBI:38263 ! 2-amino-3-hydroxybutanoic acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27001 name: thymidine phosphate namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "thymidine phosphates" RELATED [ChEBI:] is_a: CHEBI:25608 ! nucleoside phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27008 name: tin molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "tin compounds" RELATED [ChEBI:] synonym: "tin molecular entities" RELATED [ChEBI:] is_a: CHEBI:33582 ! carbon group molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27082 name: trehalose namespace: chebi_ontology def: "A disaccharide formed by a (1<->1)-glycosidic bond between two units of D-glucose." [] synonym: "C12H22O11" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C12H22O11/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12/h3-20H,1-2H2/t3-,4-,5-,6-,7+,8+,9-,10-,11?,12?/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=HDTRYLNUVZCQOY-MFAKQEFJSA-N" RELATED InChIKey [ChEBI:] synonym: "OC[C@H]1OC(OC2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O" RELATED SMILES [ChEBI:] synonym: "trehalose" EXACT [ChEBI:] is_a: CHEBI:24407 ! glycosyl glycoside property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27084 name: trehalose phosphate namespace: chebi_ontology synonym: "trehalose phosphates" RELATED [ChEBI:] is_a: CHEBI:23843 ! disaccharide phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27086 name: tributylstannane namespace: chebi_ontology def: "An organotin compound that has formula C12H28Sn." [] synonym: "[H][Sn](CCCC)(CCCC)CCCC" RELATED SMILES [ChEBI:] synonym: "[Sn(Bu)3H]" RELATED [ChEBI:] synonym: "C12H28Sn" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/3C4H9.Sn.H/c3*1-3-4-2;;/h3*1,3-4H2,2H3;;" RELATED InChI [ChEBI:] synonym: "InChIKey=DBGVGMSCBYYSLD-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "SnBu3H" RELATED [IUPAC:] synonym: "TBT" RELATED [UM-BBD:] synonym: "Tri-n-butyltin" RELATED [UM-BBD:] synonym: "Tri-n-butyltin hydride" RELATED [NIST Chemistry WebBook:] synonym: "tributylstannane" EXACT IUPAC_NAME [IUPAC:] synonym: "Tributyltin" RELATED [ChemIDplus:] xref: Beilstein:3587329 "Beilstein Registry Number" xref: ChEBI:c0579 "UM-BBD compID" xref: ChemIDplus:688-73-3 "CAS Registry Number" xref: Gmelin:4258 "Gmelin Registry Number" xref: NIST Chemistry WebBook:688-73-3 "CAS Registry Number" is_a: CHEBI:25717 ! organotin compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27134 name: trimethylxanthine namespace: chebi_ontology synonym: "trimethylxanthines" RELATED [ChEBI:] is_a: CHEBI:25348 ! methylxanthine property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27136 name: triol namespace: chebi_ontology def: "A chemical compound containing three hydroxy groups." [] synonym: "triols" RELATED [ChEBI:] is_a: CHEBI:26191 ! polyol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27137 name: triose namespace: chebi_ontology def: "A monosaccharide containing three carbon atoms, which is important in respiration. Only two trioses occur naturally: the aldotriose glyceraldehyde and the ketotriose dihydroxyacetone." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "triose" EXACT [ChEBI:] synonym: "trioses" RELATED [ChEBI:] is_a: CHEBI:35381 ! monosaccharide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27150 name: trisaccharide namespace: chebi_ontology synonym: "trisaccharides" RELATED [ChEBI:] xref: Wikipedia:Trisaccharide "Wikipedia" is_a: CHEBI:50699 ! oligosaccharide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27171 name: organic heterobicyclic compound namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "heterobicyclic compounds" RELATED [ChEBI:] synonym: "organic heterobicyclic compounds" RELATED [ChEBI:] synonym: "two-ring heterocyclic compounds" RELATED [ChEBI:] is_a: CHEBI:33672 ! heterobicyclic compound is_a: CHEBI:38166 ! organic heteropolycyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27208 name: unsaturated fatty acid namespace: chebi_ontology def: "Any fatty acid containing at least one C=C or C#C bond." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "alkene acid" RELATED [ChEBI:] synonym: "olefinic acid" RELATED [ChEBI:] synonym: "unsaturated fatty acids" RELATED [LIPID MAPS:] synonym: "unsaturated fatty acids" RELATED [ChEBI:] xref: CiteXplore:5322381 "PubMed citation" xref: LIPID MAPS:LMFA0103 "LIPID MAPS class" is_a: CHEBI:35366 ! fatty acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27242 name: uridines namespace: chebi_ontology synonym: "uridines" EXACT [ChEBI:] is_a: CHEBI:39446 ! pyrimidine ribonucleosides property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27266 name: valine namespace: chebi_ontology def: "A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isopropyl group." [] synonym: "2-amino-3-methylbutanoic acid" RELATED [IUPAC:] synonym: "C5H11NO2" RELATED FORMULA [ChEBI:] synonym: "CC(C)C(N)C(O)=O" RELATED SMILES [ChEBI:] synonym: "DL-valine" RELATED [ChEBI:] synonym: "Hval" RELATED [IUPAC:] synonym: "InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)" RELATED InChI [ChEBI:] synonym: "InChIKey=KZSNJWFQEVHDMF-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "Valin" RELATED [ChEBI:] synonym: "valina" RELATED [ChEBI:] synonym: "valine" EXACT IUPAC_NAME [IUPAC:] xref: Beilstein:506689 "Beilstein Registry Number" xref: ChemIDplus:516-06-3 "CAS Registry Number" xref: CiteXplore:17190852 "PubMed citation" xref: CiteXplore:22770225 "PubMed citation" xref: Gmelin:49877 "Gmelin Registry Number" xref: KEGG COMPOUND:516-06-3 "CAS Registry Number" xref: KEGG COMPOUND:C16436 "KEGG COMPOUND" xref: NIST Chemistry WebBook:516-06-3 "CAS Registry Number" xref: Reaxys:506689 "Reaxys Registry Number" xref: Wikipedia:Valine "Wikipedia" is_a: CHEBI:22918 ! branched-chain amino acid is_a: CHEBI:33704 ! alpha-amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27275 name: vanadium molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "vanadium compounds" RELATED [ChEBI:] synonym: "vanadium molecular entities" RELATED [ChEBI:] synonym: "vanadium molecular entity" EXACT [ChEBI:] is_a: CHEBI:33746 ! vanadium group molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27283 name: very long-chain fatty acid namespace: chebi_ontology def: "A fatty acid which has a chain length greater than C22." [] synonym: "CH2OR" RELATED FORMULA [ChEBI:] synonym: "higher fatty acid" RELATED [ChEBI:] synonym: "OC([*])=O" RELATED SMILES [ChEBI:] synonym: "very long-chain fatty acids" RELATED [ChEBI:] synonym: "VLCFA" RELATED [ChEBI:] synonym: "VLCFAs" RELATED [ChEBI:] xref: LIPID MAPS:LMFA01010025 "LIPID MAPS instance" is_a: CHEBI:35366 ! fatty acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27306 name: vitamin B6 namespace: chebi_ontology synonym: "vitamin B-6" RELATED [JCBN:] synonym: "Vitamin B6" EXACT [ChEBI:] synonym: "vitamina B6" RELATED [ChEBI:] synonym: "vitamine B6" RELATED [ChEBI:] is_a: CHEBI:26421 ! pyridines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27364 name: zinc molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "zinc compounds" RELATED [ChEBI:] synonym: "zinc molecular entities" RELATED [ChEBI:] is_a: CHEBI:33673 ! zinc group molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27365 name: zinc ion namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "zinc ion" EXACT [ChEBI:] synonym: "zinc ions" RELATED [ChEBI:] is_a: CHEBI:24867 ! monoatomic ion is_a: CHEBI:37253 ! elemental zinc property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27369 name: zwitterion namespace: chebi_ontology def: "A neutral compound having formal unit electrical charges of opposite sign on non-adjacent atoms. Sometimes referred to as inner salts, dipolar ions (a misnomer)." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "compose zwitterionique" RELATED [IUPAC:] synonym: "compuestos zwitterionicos" RELATED [IUPAC:] synonym: "zwitterion" EXACT IUPAC_NAME [IUPAC:] synonym: "zwitteriones" RELATED [IUPAC:] synonym: "zwitterionic compounds" RELATED [IUPAC:] synonym: "zwitterions" EXACT IUPAC_NAME [IUPAC:] is_a: CHEBI:51151 ! dipolar compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27504 name: mitomycin C namespace: chebi_ontology alt_id: CHEBI:25356 alt_id: CHEBI:6953 def: "A mitomycin that has formula C15H18N4O5." [] synonym: "7-Amino-9alpha-methoxymitosane" RELATED [ChemIDplus:] synonym: "[(1aS,8S,8aR,8bS)-6-amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazirino[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate" EXACT IUPAC_NAME [IUPAC:] synonym: "[H][C@]12CN3C4=C([C@@H](COC(N)=O)[C@@]3(OC)[C@@]1([H])N2)C(=O)C(N)=C(C)C4=O" RELATED SMILES [ChEBI:] synonym: "Ametycine" RELATED [ChemIDplus:] synonym: "C15H18N4O5" RELATED FORMULA [KEGG COMPOUND:] synonym: "InChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=NWIBSHFKIJFRCO-WUDYKRTCSA-N" RELATED InChIKey [ChEBI:] synonym: "Mitocin-C" RELATED [ChemIDplus:] synonym: "Mitomycin" RELATED [KEGG COMPOUND:] synonym: "Mitomycin C" EXACT [KEGG COMPOUND:] synonym: "MMC" RELATED [ChemIDplus:] synonym: "Mutamycin" RELATED [ChemIDplus:] xref: Beilstein:3570056 "Beilstein Registry Number" xref: ChemIDplus:50-07-7 "CAS Registry Number" xref: DrugBank:DB00305 "DrugBank" xref: KEGG COMPOUND:50-07-7 "CAS Registry Number" xref: KEGG COMPOUND:C06681 "KEGG COMPOUND" xref: KEGG DRUG:D00208 "KEGG DRUG" xref: KNApSAcK:C00018668 "KNApSAcK" xref: Wikipedia:Mitomycin "Wikipedia" is_a: CHEBI:25357 ! mitomycin property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27532 name: L-cysteine thioether namespace: chebi_ontology alt_id: CHEBI:23510 alt_id: CHEBI:4051 def: "Any L-cysteine derivative obtained by conversion of the thiol group into a sulfide." [] synonym: "cysteine thioether" RELATED [ChEBI:] synonym: "L-cysteine thioethers" RELATED [ChEBI:] is_a: CHEBI:16385 ! organic sulfide is_a: CHEBI:83824 ! L-cysteine derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27570 name: histidine namespace: chebi_ontology alt_id: CHEBI:24598 alt_id: CHEBI:43118 alt_id: CHEBI:5733 def: "An alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3." [] synonym: "2-amino-3-(1H-imidazol-4-yl)propanoic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "alpha-Amino-1H-imidazole-4-propionic acid" RELATED [KEGG COMPOUND:] synonym: "C6H9N3O2" RELATED FORMULA [KEGG COMPOUND:] synonym: "DL-Histidine" RELATED [KEGG COMPOUND:] synonym: "Histidin" RELATED [ChEBI:] synonym: "histidina" RELATED [ChEBI:] synonym: "Histidine" EXACT [KEGG COMPOUND:] synonym: "histidine" EXACT IUPAC_NAME [IUPAC:] synonym: "InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)" RELATED InChI [ChEBI:] synonym: "InChIKey=HNDVDQJCIGZPNO-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "NC(Cc1c[nH]cn1)C(O)=O" RELATED SMILES [ChEBI:] xref: Beilstein:84087 "Beilstein Registry Number" xref: ChemIDplus:4998-57-6 "CAS Registry Number" xref: CiteXplore:17190852 "PubMed citation" xref: CiteXplore:22264337 "PubMed citation" xref: CiteXplore:22770225 "PubMed citation" xref: Gmelin:3656 "Gmelin Registry Number" xref: KEGG COMPOUND:4998-57-6 71-00-1 "CAS Registry Number" xref: KEGG COMPOUND:C00768 "KEGG COMPOUND" xref: KNApSAcK:C00001363 "KNApSAcK" xref: Reaxys:84087 "Reaxys Registry Number" xref: Wikipedia:Histidine "Wikipedia" is_a: CHEBI:24780 ! imidazoles is_a: CHEBI:33704 ! alpha-amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27617 name: monensin A namespace: chebi_ontology alt_id: CHEBI:25376 alt_id: CHEBI:6973 def: "A spiroketal, monensin A is the major component of monensin, a mixture of antibiotic substances produced by Streptomyces cinnamonensis. An antiprotozoal, it is used as the sodium salt as a feed additive for the prevention of coccidiosis in poultry and as a growth promoter in cattle." [] synonym: "(2S,3R,4S)-4-[(2S,5R,7S,8R,9S)-2-{(2S,2'R,3'S,5R,5'R)-2-ethyl-5'-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl]-3'-methyloctahydro-2,2'-bifuran-5-yl}-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]dec-7-yl]-3-methoxy-2-methylpentanoic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "[H][C@@]1(C[C@H](C)[C@@]([H])(O1)[C@]1(CC)CC[C@@]([H])(O1)[C@]1(C)CC[C@]2(C[C@H](O)[C@@H](C)[C@]([H])(O2)[C@@H](C)[C@@H](OC)[C@H](C)C(O)=O)O1)[C@@]1([H])O[C@@](O)(CO)[C@H](C)C[C@@H]1C" RELATED SMILES [ChEBI:] synonym: "C36H62O11" RELATED FORMULA [KEGG COMPOUND:] synonym: "InChI=1S/C36H62O11/c1-10-34(31-20(3)16-26(43-31)28-19(2)15-21(4)36(41,18-37)46-28)12-11-27(44-34)33(8)13-14-35(47-33)17-25(38)22(5)30(45-35)23(6)29(42-9)24(7)32(39)40/h19-31,37-38,41H,10-18H2,1-9H3,(H,39,40)/t19-,20-,21+,22+,23-,24-,25-,26+,27+,28-,29+,30-,31+,33-,34-,35+,36-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=GAOZTHIDHYLHMS-KEOBGNEYSA-N" RELATED InChIKey [ChEBI:] synonym: "monensic acid" RELATED [ChemIDplus:] synonym: "Monensin" RELATED [KEGG COMPOUND:] synonym: "monensin" RELATED INN [ChemIDplus:] synonym: "Monensin A" EXACT [KEGG COMPOUND:] synonym: "monensina" RELATED INN [ChemIDplus:] synonym: "monensinum" RELATED INN [ChemIDplus:] xref: CiteXplore:21215424 "PubMed citation" xref: KEGG COMPOUND:17090-79-8 "CAS Registry Number" xref: KEGG COMPOUND:C06693 "KEGG COMPOUND" xref: KEGG DRUG:D08228 "KEGG DRUG" xref: Reaxys:1633130 "Reaxys Registry Number" is_a: CHEBI:25384 ! monocarboxylic acid is_a: CHEBI:26179 ! polyether antibiotic is_a: CHEBI:59780 ! cyclic hemiketal is_a: CHEBI:72600 ! spiroketal property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27641 name: cycloheximide namespace: chebi_ontology alt_id: CHEBI:23484 alt_id: CHEBI:4015 def: "A piperidine antibiotic that has formula C15H23NO4." [] synonym: "3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)glutarimide" RELATED [ChemIDplus:] synonym: "4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione" EXACT IUPAC_NAME [IUPAC:] synonym: "[H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC1CC(=O)NC(=O)C1" RELATED SMILES [ChEBI:] synonym: "C15H23NO4" RELATED FORMULA [KEGG COMPOUND:] synonym: "cicloheximida" RELATED INN [ChemIDplus:] synonym: "cicloheximidum" RELATED INN [ChemIDplus:] synonym: "Cycloheximid" RELATED [ChEBI:] synonym: "Cycloheximide" EXACT [KEGG COMPOUND:] synonym: "InChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=YPHMISFOHDHNIV-FSZOTQKASA-N" RELATED InChIKey [ChEBI:] synonym: "Zykloheximid" RELATED [ChEBI:] xref: Beilstein:88868 "Beilstein Registry Number" xref: ChemIDplus:66-81-9 "CAS Registry Number" xref: KEGG COMPOUND:66-81-9 "CAS Registry Number" xref: KEGG COMPOUND:C06685 "KEGG COMPOUND" xref: KEGG DRUG:D03625 "KEGG DRUG" xref: Wikipedia:Cycloheximide "Wikipedia" is_a: CHEBI:48589 ! piperidones is_a: CHEBI:49318 ! piperidine antibiotic property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27656 name: camptothecin namespace: chebi_ontology alt_id: CHEBI:22997 alt_id: CHEBI:3343 def: "A pyranoindolizinoquinoline that has formula C20H16N2O4." [] synonym: "(+)-camptothecin" RELATED [DrugBank:] synonym: "(+)-camptothecine" RELATED [DrugBank:] synonym: "(4S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione" EXACT IUPAC_NAME [IUPAC:] synonym: "(S)-(+)-camptothecin" RELATED [DrugBank:] synonym: "20(S)-camptothecine" RELATED [ChemIDplus:] synonym: "21,22-Secocamptothecin-21-oic acid lactone" RELATED [ChemIDplus:] synonym: "C20H16N2O4" RELATED FORMULA [ChEBI:] synonym: "Camptothecin" EXACT [KEGG COMPOUND:] synonym: "camptothecin" EXACT [ChEBI:] synonym: "Camptothecine" RELATED [ChemIDplus:] synonym: "CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccccc4cc3Cn1c2=O" RELATED SMILES [ChEBI:] synonym: "CPT" RELATED [DrugBank:] synonym: "D-camptothecin" RELATED [DrugBank:] synonym: "InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=VSJKWCGYPAHWDS-FQEVSTJZSA-N" RELATED InChIKey [ChEBI:] xref: Beilstein:6075662 "Beilstein Registry Number" xref: ChemIDplus:7689-03-4 "CAS Registry Number" xref: CiteXplore:11024478 "PubMed citation" xref: CiteXplore:11549373 "PubMed citation" xref: CiteXplore:21348469 "PubMed citation" xref: CiteXplore:23344961 "PubMed citation" xref: CiteXplore:23474217 "PubMed citation" xref: CiteXplore:23676007 "PubMed citation" xref: CiteXplore:8965250 "PubMed citation" xref: DrugBank:DB04690 "DrugBank" xref: KEGG COMPOUND:7689-03-4 "CAS Registry Number" xref: KEGG COMPOUND:C01897 "KEGG COMPOUND" xref: KNApSAcK:C00002145 "KNApSAcK" xref: PDBeChem:EHD "PDBeChem" xref: Reaxys:6075662 "Reaxys Registry Number" xref: Wikipedia:Camptothecin "Wikipedia" is_a: CHEBI:26509 ! quinoline alkaloid is_a: CHEBI:48626 ! pyranoindolizinoquinoline property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27659 name: 2-oxo aldehyde namespace: chebi_ontology alt_id: CHEBI:1248 alt_id: CHEBI:13595 alt_id: CHEBI:19739 def: "Any aldehyde having an oxo substituent at the 2-position." [] synonym: "2-oxo aldehydes" RELATED [ChEBI:] synonym: "2-Oxoaldehyde" RELATED [KEGG COMPOUND:] synonym: "2-oxoaldehyde" RELATED [UniProt:] synonym: "[H]C(=O)C(C)=O" RELATED SMILES [ChEBI:] synonym: "C2HO2R" RELATED FORMULA [ChEBI:] xref: KEGG COMPOUND:C00538 "KEGG COMPOUND" is_a: CHEBI:24960 ! ketoaldehyde property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27666 name: actinomycin D namespace: chebi_ontology alt_id: CHEBI:22218 alt_id: CHEBI:2446 def: "An actinomycin that has formula C62H86N12O16." [] synonym: "2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis-[(18aS)-10c,14,17-trimethyl-5,8,12,15,18-pentaoxo-6c,13t-di(propan-2-yl)-18ar-hexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-9c-yl]-3H-phenoxazine-1,9-dicarboxamide" EXACT IUPAC_NAME [IUPAC:] synonym: "2-amino-N,N'-bis(hexadecahydro-2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxo-1H-pyrrolo(2,1-i)(1,4,7,10,13)oxatetra-azacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide" RELATED [ChemIDplus:] synonym: "[H][C@@]12CCCN1C(=O)[C@H](NC(=O)[C@@H](NC(=O)c1ccc(C)c3oc4c(C)c(=O)c(N)c(C(=O)N[C@H]5[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@]6([H])CCCN6C(=O)[C@H](NC5=O)C(C)C)c4nc13)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C2=O)C(C)C" RELATED SMILES [ChEBI:] synonym: "ActD" RELATED [ChEBI:] synonym: "actinomycin C1" RELATED [ChEBI:] synonym: "Actinomycin D" EXACT [KEGG COMPOUND:] synonym: "actinomycin IV" RELATED [ChemIDplus:] synonym: "C62H86N12O16" RELATED FORMULA [KEGG COMPOUND:] synonym: "Dactinomycin" RELATED [KEGG COMPOUND:] synonym: "InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=RJURFGZVJUQBHK-IIXSONLDSA-N" RELATED InChIKey [ChEBI:] xref: Beilstein:4173766 "Beilstein Registry Number" xref: ChemIDplus:50-76-0 "CAS Registry Number" xref: DrugBank:DB00970 "DrugBank" xref: KEGG COMPOUND:50-76-0 "CAS Registry Number" xref: KEGG COMPOUND:C06770 "KEGG COMPOUND" xref: KEGG DRUG:D00214 "KEGG DRUG" xref: Wikipedia:Dactinomycin "Wikipedia" is_a: CHEBI:15369 ! actinomycin property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27680 name: galactomannan namespace: chebi_ontology alt_id: CHEBI:24146 alt_id: CHEBI:5255 def: "A heteroglycan consisting of a mannan backbone with galactose side groups." [] synonym: "C18H32O16" RELATED FORMULA [KEGG COMPOUND:] synonym: "Galactomannan" EXACT [KEGG COMPOUND:] synonym: "galactomannan" EXACT [ChEBI:] synonym: "Galactomannoglycan" RELATED [KEGG COMPOUND:] synonym: "galactomannoglycan" RELATED [ChEBI:] synonym: "InChI=1S/C18H32O16/c19-1-4-7(21)9(23)13(27)17(32-4)30-3-6-15(11(25)12(26)16(29)31-6)34-18-14(28)10(24)8(22)5(2-20)33-18/h4-29H,1-3H2/t4-,5-,6-,7+,8-,9+,10+,11-,12+,13-,14+,15-,16-,17+,18+/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=OMDQUFIYNPYJFM-XKDAHURESA-N" RELATED InChIKey [ChEBI:] synonym: "OC[C@H]1O[C@H](OC[C@H]2O[C@@H](O)[C@@H](O)[C@@H](O)[C@@H]2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@H]1O" RELATED SMILES [ChEBI:] xref: CiteXplore:1375195 "PubMed citation" xref: CiteXplore:2426444 "PubMed citation" xref: KEGG COMPOUND:C00883 "KEGG COMPOUND" is_a: CHEBI:61298 ! D-glucose- and/or D-galactose-substituted mannan property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27732 name: caffeine namespace: chebi_ontology alt_id: CHEBI:22982 alt_id: CHEBI:3295 alt_id: CHEBI:41472 def: "A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee." [] synonym: "1,3,7-trimethyl-2,6-dioxopurine" RELATED [ChemIDplus:] synonym: "1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione" EXACT IUPAC_NAME [IUPAC:] synonym: "1,3,7-trimethylpurine-2,6-dione" RELATED [IUPHAR:] synonym: "1,3,7-Trimethylxanthine" RELATED [KEGG COMPOUND:] synonym: "1,3,7-trimethylxanthine" RELATED [NIST Chemistry WebBook:] synonym: "1-methyltheobromine" RELATED [ChemIDplus:] synonym: "3,7-Dihydro-1,3,7-trimethyl-1H-purin-2,6-dion" RELATED [NIST Chemistry WebBook:] synonym: "7-methyltheophylline" RELATED [NIST Chemistry WebBook:] synonym: "anhydrous caffeine" RELATED [KEGG DRUG:] synonym: "C8H10N4O2" RELATED FORMULA [KEGG COMPOUND:] synonym: "cafeina" RELATED [ChemIDplus:] synonym: "cafeine" RELATED [ChEBI:] synonym: "CAFFEINE" EXACT [PDBeChem:] synonym: "Caffeine" EXACT [KEGG COMPOUND:] synonym: "caffeine" EXACT [UniProt:] synonym: "Cn1cnc2n(C)c(=O)n(C)c(=O)c12" RELATED SMILES [ChEBI:] synonym: "Coffein" RELATED [ChemIDplus:] synonym: "guaranine" RELATED [IUPHAR:] synonym: "InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3" RELATED InChI [ChEBI:] synonym: "InChIKey=RYYVLZVUVIJVGH-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "Koffein" RELATED [ChemIDplus:] synonym: "mateina" RELATED [ChemIDplus:] synonym: "methyltheobromine" RELATED [IUPHAR:] synonym: "teina" RELATED [ChEBI:] synonym: "Thein" RELATED [ChemIDplus:] synonym: "theine" RELATED [NIST Chemistry WebBook:] xref: Beilstein:17705 "Beilstein Registry Number" xref: ChemIDplus:58-08-2 "CAS Registry Number" xref: CiteXplore:10510174 "PubMed citation" xref: CiteXplore:10796597 "PubMed citation" xref: CiteXplore:10803761 "PubMed citation" xref: CiteXplore:10822912 "PubMed citation" xref: CiteXplore:10884512 "PubMed citation" xref: CiteXplore:10924888 "PubMed citation" xref: CiteXplore:10983026 "PubMed citation" xref: CiteXplore:11014293 "PubMed citation" xref: CiteXplore:11022879 "PubMed citation" xref: CiteXplore:11209966 "PubMed citation" xref: CiteXplore:11312039 "PubMed citation" xref: CiteXplore:11410911 "PubMed citation" xref: CiteXplore:11431501 "PubMed citation" xref: CiteXplore:11815511 "PubMed citation" xref: CiteXplore:11949272 "PubMed citation" xref: CiteXplore:12397877 "PubMed citation" xref: CiteXplore:12457274 "PubMed citation" xref: CiteXplore:12574990 "PubMed citation" xref: CiteXplore:12915014 "PubMed citation" xref: CiteXplore:12943586 "PubMed citation" xref: CiteXplore:14521986 "PubMed citation" xref: CiteXplore:14607010 "PubMed citation" xref: CiteXplore:15257305 "PubMed citation" xref: CiteXplore:15280431 "PubMed citation" xref: CiteXplore:15681408 "PubMed citation" xref: CiteXplore:15718055 "PubMed citation" xref: CiteXplore:15840517 "PubMed citation" xref: CiteXplore:16143823 "PubMed citation" xref: CiteXplore:16391865 "PubMed citation" xref: CiteXplore:16528931 "PubMed citation" xref: CiteXplore:16644114 "PubMed citation" xref: CiteXplore:16709440 "PubMed citation" xref: CiteXplore:16805851 "PubMed citation" xref: CiteXplore:16856769 "PubMed citation" xref: CiteXplore:17132260 "PubMed citation" xref: CiteXplore:17387608 "PubMed citation" xref: CiteXplore:17508167 "PubMed citation" xref: CiteXplore:17724925 "PubMed citation" xref: CiteXplore:17932622 "PubMed citation" xref: CiteXplore:17957400 "PubMed citation" xref: CiteXplore:18068204 "PubMed citation" xref: CiteXplore:18258404 "PubMed citation" xref: CiteXplore:18421070 "PubMed citation" xref: CiteXplore:18625110 "PubMed citation" xref: CiteXplore:18647558 "PubMed citation" xref: CiteXplore:19007524 "PubMed citation" xref: CiteXplore:19047957 "PubMed citation" xref: CiteXplore:19084078 "PubMed citation" xref: CiteXplore:19088793 "PubMed citation" xref: CiteXplore:19418355 "PubMed citation" xref: CiteXplore:19879252 "PubMed citation" xref: CiteXplore:20164568 "PubMed citation" xref: CiteXplore:20470411 "PubMed citation" xref: CiteXplore:22770225 "PubMed citation" xref: CiteXplore:7441110 "PubMed citation" xref: CiteXplore:7689104 "PubMed citation" xref: CiteXplore:8332255 "PubMed citation" xref: CiteXplore:8347173 "PubMed citation" xref: CiteXplore:8679661 "PubMed citation" xref: CiteXplore:9063686 "PubMed citation" xref: CiteXplore:9067318 "PubMed citation" xref: CiteXplore:9132918 "PubMed citation" xref: CiteXplore:9218278 "PubMed citation" xref: DrugBank:DB00201 "DrugBank" xref: Gmelin:103040 "Gmelin Registry Number" xref: HMDB:HMDB01847 "HMDB" xref: KEGG COMPOUND:58-08-2 "CAS Registry Number" xref: KEGG COMPOUND:C07481 "KEGG COMPOUND" xref: KEGG DRUG:D00528 "KEGG DRUG" xref: KNApSAcK:C00001492 "KNApSAcK" xref: MetaCyc:1-3-7-TRIMETHYLXANTHINE "MetaCyc" xref: NIST Chemistry WebBook:58-08-2 "CAS Registry Number" xref: PDBeChem:CFF "PDBeChem" xref: Reaxys:17705 "Reaxys Registry Number" xref: Wikipedia:Caffeine "Wikipedia" is_a: CHEBI:27134 ! trimethylxanthine property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27897 name: tryptophan namespace: chebi_ontology alt_id: CHEBI:27163 alt_id: CHEBI:9769 def: "An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3." [] synonym: "2-amino-3-(1H-indol-3-yl)propanoic acid" RELATED [IUPAC:] synonym: "alpha-Amino-beta-(3-indolyl)-propionic acid" RELATED [KEGG COMPOUND:] synonym: "alpha-amino-beta-3-indolepropionic acid" RELATED [ChEBI:] synonym: "beta-3-indolylalanine" RELATED [ChEBI:] synonym: "C11H12N2O2" RELATED FORMULA [KEGG COMPOUND:] synonym: "Htrp" RELATED [IUPAC:] synonym: "InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)" RELATED InChI [ChEBI:] synonym: "InChIKey=QIVBCDIJIAJPQS-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "NC(Cc1c[nH]c2ccccc12)C(O)=O" RELATED SMILES [ChEBI:] synonym: "triptofano" RELATED [ChEBI:] synonym: "Trp" RELATED [ChEBI:] synonym: "Tryptophan" EXACT [KEGG COMPOUND:] synonym: "tryptophan" EXACT IUPAC_NAME [IUPAC:] synonym: "tryptophane" RELATED [ChEBI:] synonym: "W" RELATED [ChEBI:] xref: Beilstein:86196 "Beilstein Registry Number" xref: ChemIDplus:54-12-6 "CAS Registry Number" xref: CiteXplore:17439666 "PubMed citation" xref: CiteXplore:22264337 "PubMed citation" xref: Gmelin:4532 "Gmelin Registry Number" xref: KEGG COMPOUND:54-12-6 "CAS Registry Number" xref: KEGG COMPOUND:C00806 "KEGG COMPOUND" xref: KNApSAcK:C00001396 "KNApSAcK" xref: NIST Chemistry WebBook:54-12-6 "CAS Registry Number" xref: Reaxys:86196 "Reaxys Registry Number" xref: Wikipedia:Tryptophan "Wikipedia" is_a: CHEBI:33704 ! alpha-amino acid is_a: CHEBI:33856 ! aromatic amino acid is_a: CHEBI:38631 ! aminoalkylindole property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27899 name: cisplatin namespace: chebi_ontology alt_id: CHEBI:23314 alt_id: CHEBI:3722 def: "A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary." [] synonym: "(SP-4-2)-diamminedichloridoplatinum" EXACT IUPAC_NAME [IUPAC:] synonym: "(SP-4-2)-diamminedichloroplatinum" EXACT IUPAC_NAME [IUPAC:] synonym: "[H][N]([H])([H])[Pt](Cl)(Cl)[N]([H])([H])[H]" RELATED SMILES [ChEBI:] synonym: "[PtCl2(NH3)2]" RELATED [KEGG COMPOUND:] synonym: "Briplatin" RELATED BRAND_NAME [ChemIDplus:] synonym: "CDDP" RELATED [KEGG COMPOUND:] synonym: "cis-[PtCl2(NH3)2]" RELATED [MolBase:] synonym: "cis-DDP" RELATED [ChemIDplus:] synonym: "cis-diamminedichloridoplatinum(II)" EXACT IUPAC_NAME [IUPAC:] synonym: "cis-diamminedichloroplatinum" RELATED [ChemIDplus:] synonym: "cis-Diamminedichloroplatinum(II)" RELATED [KEGG COMPOUND:] synonym: "cis-diamminedichloroplatinum(II)" EXACT IUPAC_NAME [IUPAC:] synonym: "cis-diammineplatinum(II) dichloride" RELATED [ChemIDplus:] synonym: "cis-dichlorodiammineplatinum(II)" RELATED [ChemIDplus:] synonym: "cis-platin" RELATED [ChEBI:] synonym: "Cismaplat" RELATED BRAND_NAME [DrugBank:] synonym: "Cisplatin" EXACT [KEGG COMPOUND:] synonym: "cisplatin" RELATED INN [ChemIDplus:] synonym: "cisplatine" RELATED INN [ChemIDplus:] synonym: "cisplatino" RELATED INN [ChemIDplus:] synonym: "cisplatinum" RELATED INN [ChemIDplus:] synonym: "Cl2H6N2Pt" RELATED FORMULA [ChEBI:] synonym: "H6Cl2N2Pt" RELATED FORMULA [KEGG COMPOUND:] synonym: "InChI=1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2" RELATED InChI [ChEBI:] synonym: "InChIKey=LXZZYRPGZAFOLE-UHFFFAOYSA-L" RELATED InChIKey [ChEBI:] synonym: "Lederplatin" RELATED BRAND_NAME [DrugBank:] synonym: "Neoplatin" RELATED BRAND_NAME [DrugBank:] synonym: "Peyrone's chloride" RELATED [ChemIDplus:] synonym: "Peyrone's salt" RELATED [ChEBI:] synonym: "Platamine" RELATED [DrugBank:] synonym: "Platinex" RELATED BRAND_NAME [DrugBank:] synonym: "Platinol" RELATED BRAND_NAME [KEGG DRUG:] synonym: "Randa" RELATED BRAND_NAME [DrugBank:] xref: ChemIDplus:15663-27-1 "CAS Registry Number" xref: CiteXplore:10883661 "PubMed citation" xref: CiteXplore:12537968 "PubMed citation" xref: CiteXplore:12831510 "PubMed citation" xref: CiteXplore:12935404 "PubMed citation" xref: CiteXplore:16327988 "PubMed citation" xref: CiteXplore:18472761 "PubMed citation" xref: CiteXplore:1855275 "PubMed citation" xref: CiteXplore:23554447 "PubMed citation" xref: CiteXplore:23604226 "PubMed citation" xref: CiteXplore:23651576 "PubMed citation" xref: DrugBank:DB00515 "DrugBank" xref: Gmelin:2519 "Gmelin Registry Number" xref: HMDB:HMDB14656 "HMDB" xref: KEGG COMPOUND:15663-27-1 "CAS Registry Number" xref: KEGG COMPOUND:C06911 "KEGG COMPOUND" xref: KEGG DRUG:D00275 "KEGG DRUG" xref: MetaCyc:CPD0-1392 "MetaCyc" xref: MolBase:25 "MolBase" xref: Patent:DE2318020 "Patent" xref: Patent:DE2329485 "Patent" xref: Reaxys:11324567 "Reaxys Registry Number" xref: Wikipedia:Cisplatin "Wikipedia" is_a: CHEBI:51214 ! diamminedichloroplatinum property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:27902 name: tetracycline namespace: chebi_ontology alt_id: CHEBI:26894 alt_id: CHEBI:45729 alt_id: CHEBI:9474 def: "A broad-spectrum polyketide antibiotic produced by the Streptomyces genus of actinobacteria." [] synonym: "(4S,4aS,5aS,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide" RELATED [ChemIDplus:] synonym: "(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide" EXACT IUPAC_NAME [IUPAC:] synonym: "[H][C@@]12C[C@@]3([H])C(C(=O)c4c(O)cccc4[C@@]3(C)O)=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C" RELATED SMILES [ChEBI:] synonym: "Abramycin" RELATED [ChemIDplus:] synonym: "Achromycin" RELATED [ChEBI:] synonym: "Anhydrotetracycline" RELATED [DrugBank:] synonym: "C22H24N2O8" RELATED FORMULA [KEGG COMPOUND:] synonym: "Deschlorobiomycin" RELATED [ChemIDplus:] synonym: "InChI=1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=OFVLGDICTFRJMM-WESIUVDSSA-N" RELATED InChIKey [ChEBI:] synonym: "Liquamycin" RELATED [ChemIDplus:] synonym: "Tetracyclin" RELATED [ChEBI:] synonym: "TETRACYCLINE" EXACT [PDBeChem:] synonym: "Tetracycline" EXACT [KEGG COMPOUND:] synonym: "Tetracycline" EXACT [ChEMBL:] synonym: "tetracycline" EXACT [ChEBI:] synonym: "tetracycline" RELATED INN [ChemIDplus:] synonym: "tetracyclinum" RELATED INN [ChemIDplus:] synonym: "Tetrazyklin" RELATED [ChEBI:] synonym: "Tsiklomitsin" RELATED [ChemIDplus:] xref: Beilstein:2230417 "Beilstein Registry Number" xref: ChEMBL:19117754 "PubMed citation" xref: ChemIDplus:60-54-8 "CAS Registry Number" xref: CiteXplore:11061623 "PubMed citation" xref: CiteXplore:11550419 "PubMed citation" xref: CiteXplore:11744940 "PubMed citation" xref: CiteXplore:12934399 "PubMed citation" xref: CiteXplore:14585720 "PubMed citation" xref: CiteXplore:15825421 "PubMed citation" xref: CiteXplore:15913752 "PubMed citation" xref: CiteXplore:16443056 "PubMed citation" xref: CiteXplore:1650428 "PubMed citation" xref: CiteXplore:16749547 "PubMed citation" xref: CiteXplore:17251127 "PubMed citation" xref: CiteXplore:17260506 "PubMed citation" xref: CiteXplore:18326855 "PubMed citation" xref: CiteXplore:18406588 "PubMed citation" xref: CiteXplore:19032078 "PubMed citation" xref: CiteXplore:19112759 "PubMed citation" xref: CiteXplore:19136803 "PubMed citation" xref: DrugBank:DB00759 "DrugBank" xref: Gmelin:1103368 "Gmelin Registry Number" xref: KEGG COMPOUND:60-54-8 "CAS Registry Number" xref: KEGG COMPOUND:C06570 "KEGG COMPOUND" xref: KEGG DRUG:D00201 "KEGG DRUG" xref: MetaCyc:CPD0-1414 "MetaCyc" xref: Patent:US2699054 "Patent" xref: Patent:US2712517 "Patent" xref: Patent:US2886595 "Patent" xref: Patent:US3005023 "Patent" xref: Patent:US3019173 "Patent" xref: Patent:US3301899 "Patent" xref: PDBeChem:TAC "PDBeChem" xref: Reaxys:2230417 "Reaxys Registry Number" xref: Wikipedia:Tetracycline "Wikipedia" is_a: CHEBI:26895 ! tetracyclines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:28044 name: phenylalanine namespace: chebi_ontology alt_id: CHEBI:25984 alt_id: CHEBI:8089 def: "An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group." [] synonym: "2-amino-3-phenylpropanoic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "alpha-Amino-beta-phenylpropionic acid" RELATED [KEGG COMPOUND:] synonym: "C9H11NO2" RELATED FORMULA [KEGG COMPOUND:] synonym: "DL-Phenylalanine" RELATED [KEGG COMPOUND:] synonym: "F" RELATED [ChEBI:] synonym: "fenilalanina" RELATED [ChEBI:] synonym: "InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)" RELATED InChI [ChEBI:] synonym: "InChIKey=COLNVLDHVKWLRT-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "NC(Cc1ccccc1)C(O)=O" RELATED SMILES [ChEBI:] synonym: "PHE" RELATED [ChEBI:] synonym: "Phenylalanin" RELATED [ChEBI:] synonym: "Phenylalanine" EXACT [KEGG COMPOUND:] synonym: "phenylalanine" EXACT [ChEBI:] synonym: "phenylalanine" EXACT IUPAC_NAME [IUPAC:] xref: Beilstein:1910407 "Beilstein Registry Number" xref: ChemIDplus:150-30-1 "CAS Registry Number" xref: CiteXplore:17439666 "PubMed citation" xref: CiteXplore:22264337 "PubMed citation" xref: Gmelin:50836 "Gmelin Registry Number" xref: KEGG COMPOUND:C02057 "KEGG COMPOUND" xref: NIST Chemistry WebBook:150-30-1 "CAS Registry Number" xref: Reaxys:1910407 "Reaxys Registry Number" xref: Wikipedia:Phenylalanine "Wikipedia" is_a: CHEBI:33704 ! alpha-amino acid is_a: CHEBI:33856 ! aromatic amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:28163 name: iron(III) hydroxamate namespace: chebi_ontology alt_id: CHEBI:21131 alt_id: CHEBI:4992 def: "A complex between iron(III) and three hydroxamic acid groups, used for iron transport." [] synonym: "[*]C1=[O][Fe]234(ON1)ONC([*])=[O]2.[*]C(NO3)=[O]4" RELATED SMILES [ChEBI:] synonym: "C3H3FeN3O6R3" RELATED FORMULA [ChEBI:] synonym: "C3H6FeN3O6R3" RELATED FORMULA [KEGG COMPOUND:] synonym: "Fe(III) hydroxamate" RELATED [ChEBI:] synonym: "Fe(III) hydroxamates" RELATED [ChEBI:] synonym: "Fe(III)hydroxamate" RELATED [KEGG COMPOUND:] synonym: "Fe(III)hydroxamic acid" RELATED [KEGG COMPOUND:] synonym: "iron(III) hydroxamates" RELATED [ChEBI:] xref: KEGG COMPOUND:C06227 "KEGG COMPOUND" is_a: CHEBI:5975 ! iron chelate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:28201 name: rotenone namespace: chebi_ontology alt_id: CHEBI:26583 alt_id: CHEBI:8897 def: "A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica)." [] synonym: "(-)-cis-rotenone" RELATED [ChemIDplus:] synonym: "(-)-rotenone" RELATED [ChemIDplus:] synonym: "(12aS,6aS,2R)-8,9-dimethoxy-2-(1-methylvinyl)-1,2-dihydrochromano[3,4-b]furano [2,3-h]chroman-6-one" RELATED [ChEBI:] synonym: "(2R,6aS,12aS)-1,2,6,6a,12,12a-hexahydro-2-isopropenyl-8,9-dimethoxychromeno(3,4-b)furo(2,3-h)chromen-6-one" RELATED [ChEBI:] synonym: "(2R,6aS,12aS)-8,9-dimethoxy-2-(prop-1-en-2-yl)-1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one" EXACT IUPAC_NAME [IUPAC:] synonym: "5'beta-rotenone" RELATED [NIST Chemistry WebBook:] synonym: "[2R-(2alpha,6aalpha,12aalpha)]-1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)[1]benzopyrano[3,4-b]furo[2,3-H][1]benzopyran-6(6aH)-one" RELATED [NIST Chemistry WebBook:] synonym: "[H][C@@]1(Cc2c(O1)ccc1C(=O)[C@@]3([H])c4cc(OC)c(OC)cc4OC[C@@]3([H])Oc21)C(C)=C" RELATED SMILES [ChEBI:] synonym: "barbasco" RELATED [ChemIDplus:] synonym: "C23H22O6" RELATED FORMULA [ChEBI:] synonym: "canex" RELATED [ChemIDplus:] synonym: "dactinol" RELATED [ChemIDplus:] synonym: "Deril" RELATED [ChEBI:] synonym: "Derrin" RELATED [ChEBI:] synonym: "Derris" RELATED [ChEBI:] synonym: "InChI=1S/C23H22O6/c1-11(2)16-8-14-15(28-16)6-5-12-22(24)21-13-7-18(25-3)19(26-4)9-17(13)27-10-20(21)29-23(12)14/h5-7,9,16,20-21H,1,8,10H2,2-4H3/t16-,20-,21+/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=JUVIOZPCNVVQFO-HBGVWJBISA-N" RELATED InChIKey [ChEBI:] synonym: "noxfire" RELATED [ChemIDplus:] synonym: "paraderil" RELATED [ChemIDplus:] synonym: "Ronone" RELATED [ChEBI:] synonym: "Rotenone" EXACT [KEGG COMPOUND:] synonym: "Rotocide" RELATED [ChEBI:] synonym: "Synpren" RELATED [ChEBI:] synonym: "tubatoxin" RELATED [ChemIDplus:] xref: Beilstein:99070 "Beilstein Registry Number" xref: ChemIDplus:83-79-4 "CAS Registry Number" xref: CiteXplore:14976342 "PubMed citation" xref: CiteXplore:15043430 "PubMed citation" xref: CiteXplore:15790535 "PubMed citation" xref: CiteXplore:17077549 "PubMed citation" xref: CiteXplore:19013527 "PubMed citation" xref: CiteXplore:21452840 "PubMed citation" xref: KEGG COMPOUND:83-79-4 "CAS Registry Number" xref: KEGG COMPOUND:C07593 "KEGG COMPOUND" xref: KNApSAcK:C00002568 "KNApSAcK" xref: LIPID MAPS:LMPK12060007 "LIPID MAPS instance" xref: NIST Chemistry WebBook:83-79-4 "CAS Registry Number" xref: Patent:CN102007944 "Patent" xref: Patent:CN102090406 "Patent" xref: Reaxys:99070 "Reaxys Registry Number" xref: Wikipedia:Rotenone "Wikipedia" is_a: CHEBI:38164 ! organic heteropentacyclic compound is_a: CHEBI:72581 ! rotenones property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:28260 name: galactose namespace: chebi_ontology alt_id: CHEBI:24162 alt_id: CHEBI:33933 alt_id: CHEBI:5256 def: "An aldohexose that is the C-4 epimer of glucose." [] synonym: "C6H12O6" RELATED FORMULA [KEGG COMPOUND:] synonym: "Gal" RELATED [JCBN:] synonym: "galacto-hexose" EXACT IUPAC_NAME [IUPAC:] synonym: "Galactose" EXACT [KEGG COMPOUND:] synonym: "galactose" EXACT IUPAC_NAME [IUPAC:] synonym: "Galaktose" RELATED [ChEBI:] xref: ChemIDplus:26566-61-0 "CAS Registry Number" xref: KEGG COMPOUND:C01582 "KEGG COMPOUND" xref: NIST Chemistry WebBook:26566-61-0 "CAS Registry Number" xref: Wikipedia:Galactose "Wikipedia" is_a: CHEBI:33917 ! aldohexose property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:28262 name: dimethyl sulfoxide namespace: chebi_ontology alt_id: CHEBI:23801 alt_id: CHEBI:42138 alt_id: CHEBI:4612 def: "A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents." [] synonym: "(CH3)2SO" RELATED [NIST Chemistry WebBook:] synonym: "(methanesulfinyl)methane" EXACT IUPAC_NAME [IUPAC:] synonym: "C2H6OS" RELATED FORMULA [KEGG COMPOUND:] synonym: "CS(C)=O" RELATED SMILES [ChEBI:] synonym: "DIMETHYL SULFOXIDE" EXACT [PDBeChem:] synonym: "Dimethyl sulfoxide" EXACT [KEGG COMPOUND:] synonym: "dimethyl sulfoxide" EXACT IUPAC_NAME [IUPAC:] synonym: "dimethyl sulfoxide" EXACT [UniProt:] synonym: "dimethyl sulfoxide" RELATED INN [ChemIDplus:] synonym: "dimethyl sulfur oxide" RELATED [NIST Chemistry WebBook:] synonym: "dimethyl sulphoxide" RELATED [ChemIDplus:] synonym: "dimethyli sulfoxidum" RELATED INN [ChemIDplus:] synonym: "Dimethylsulfoxid" RELATED [ChEBI:] synonym: "dimethylsulfoxyde" RELATED INN [ChemIDplus:] synonym: "dimetil sulfoxido" RELATED INN [ChemIDplus:] synonym: "DMSO" RELATED [KEGG COMPOUND:] synonym: "dmso" RELATED [IUPAC:] synonym: "InChI=1S/C2H6OS/c1-4(2)3/h1-2H3" RELATED InChI [ChEBI:] synonym: "InChIKey=IAZDPXIOMUYVGZ-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "methylsulfinylmethane" RELATED [ChemIDplus:] synonym: "S(O)Me2" RELATED [ChEBI:] synonym: "sulfinylbis(methane)" RELATED [ChemIDplus:] xref: Beilstein:506008 "Beilstein Registry Number" xref: ChemIDplus:67-68-5 "CAS Registry Number" xref: CiteXplore:11162043 "PubMed citation" xref: CiteXplore:11350866 "PubMed citation" xref: CiteXplore:15237653 "PubMed citation" xref: CiteXplore:15588915 "PubMed citation" xref: CiteXplore:15868171 "PubMed citation" xref: CiteXplore:16434015 "PubMed citation" xref: CiteXplore:19096138 "PubMed citation" xref: CiteXplore:19382398 "PubMed citation" xref: CiteXplore:21426213 "PubMed citation" xref: CiteXplore:22030943 "PubMed citation" xref: CiteXplore:22722716 "PubMed citation" xref: CiteXplore:22768202 "PubMed citation" xref: CiteXplore:22814967 "PubMed citation" xref: DrugBank:DB01093 "DrugBank" xref: Gmelin:1556 "Gmelin Registry Number" xref: HMDB:HMDB02151 "HMDB" xref: KEGG COMPOUND:67-68-5 "CAS Registry Number" xref: KEGG COMPOUND:C11143 "KEGG COMPOUND" xref: KEGG DRUG:D01043 "KEGG DRUG" xref: NIST Chemistry WebBook:67-68-5 "CAS Registry Number" xref: PDBeChem:DMS "PDBeChem" xref: Reaxys:506008 "Reaxys Registry Number" xref: UM-BBD:c0236 "UM-BBD compID" xref: Wikipedia:Dimethyl_Sulfoxide "Wikipedia" is_a: CHEBI:35813 ! sulfoxide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:28300 name: glutamine namespace: chebi_ontology alt_id: CHEBI:24316 alt_id: CHEBI:5432 def: "An alpha-amino acid that consists of butyric acid bearing an amino substituent at position 2 and a carbamoyl substituent at position 4." [] synonym: "2,5-diamino-5-oxopentanoic acid" RELATED [IUPAC:] synonym: "2-amino-4-carbamoylbutanoic acid" RELATED [JCBN:] synonym: "2-Aminoglutaramic acid" RELATED [KEGG COMPOUND:] synonym: "C5H10N2O3" RELATED FORMULA [KEGG COMPOUND:] synonym: "glutamic acid gamma-amide" RELATED [ChEBI:] synonym: "Glutamin" RELATED [ChEBI:] synonym: "Glutamine" EXACT [KEGG COMPOUND:] synonym: "glutamine" EXACT IUPAC_NAME [IUPAC:] synonym: "Glutaminsaeure-5-amid" RELATED [ChEBI:] synonym: "Hgln" RELATED [IUPAC:] synonym: "InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)" RELATED InChI [ChEBI:] synonym: "InChIKey=ZDXPYRJPNDTMRX-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "NC(CCC(N)=O)C(O)=O" RELATED SMILES [ChEBI:] xref: Beilstein:1723795 "Beilstein Registry Number" xref: ChemIDplus:585-21-7 "CAS Registry Number" xref: ChemIDplus:6899-04-3 "CAS Registry Number" xref: Gmelin:27318 "Gmelin Registry Number" xref: KEGG COMPOUND:6899-04-3 "CAS Registry Number" xref: KEGG COMPOUND:C00303 "KEGG COMPOUND" xref: KNApSAcK:C00001359 "KNApSAcK" xref: Reaxys:1723795 "Reaxys Registry Number" xref: Wikipedia:Glutamine "Wikipedia" is_a: CHEBI:33704 ! alpha-amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:28545 name: valinomycin namespace: chebi_ontology alt_id: CHEBI:27269 alt_id: CHEBI:66347 alt_id: CHEBI:9924 def: "A twelve-membered cyclodepsipeptide composed of three repeating D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl units joined in sequence. An antibiotic found in several Streptomyces strains." [] synonym: "(3R,6R,9S,12S,15R,18R,21S,24S,27R,30R,33S,36S)-3,6,9,15,18,21,27,30,33-nonaisopropyl-12,24,36-trimethyl-1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexaazacyclohexatriacontane-2,5,8,11,14,17,20,23,26,29,32,35-dodecone" EXACT IUPAC_NAME [IUPAC:] synonym: "C54H90N6O18" RELATED FORMULA [ChEBI:] synonym: "CC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC1=O)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C" RELATED SMILES [ChEBI:] synonym: "Cyclic(D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl)" RELATED [ChemIDplus:] synonym: "cyclo[-D-O-Val-D-Val-L-O-Ala-L-Val]3" RELATED [ChEBI:] synonym: "InChI=1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)/t31-,32-,33-,34+,35+,36+,37-,38-,39-,40+,41+,42+/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=FCFNRCROJUBPLU-DNDCDFAISA-N" RELATED InChIKey [ChEBI:] synonym: "Valinomycin" EXACT [KEGG COMPOUND:] xref: Beilstein:78657 "Beilstein Registry Number" xref: ChemIDplus:2001-95-8 "CAS Registry Number" xref: ChemIDplus:78657 "Beilstein Registry Number" xref: CiteXplore:10603383 "PubMed citation" xref: CiteXplore:18633285 "PubMed citation" xref: CiteXplore:19347893 "PubMed citation" xref: CiteXplore:22683555 "PubMed citation" xref: CiteXplore:7590182 "PubMed citation" xref: KEGG COMPOUND:2001-95-8 "CAS Registry Number" xref: KEGG COMPOUND:C06684 "KEGG COMPOUND" xref: Reaxys:78657 "Reaxys Registry Number" xref: Wikipedia:Valinomycin "Wikipedia" is_a: CHEBI:35213 ! cyclodepsipeptide is_a: CHEBI:51026 ! macrocycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:28592 name: ricinoleic acid namespace: chebi_ontology alt_id: CHEBI:26575 alt_id: CHEBI:8854 def: "A straight-chain, 18:1, long-chain fatty acid having a cis- double bond at position 9 and an R-oriented hydroxy group at position 12." [] synonym: "(9Z)-(12S)-Hydroxyoctadecenoic acid" RELATED [KEGG COMPOUND:] synonym: "(9Z,12R)-12-hydroxyoctadec-9-enoic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "(cis,R)-12-hydroxyoctadec-9-enoic acid" RELATED [ChEBI:] synonym: "(Z,R)-12-hydroxyoctadec-9-enoic acid" RELATED [ChEBI:] synonym: "12-Hydroxy-9-octadecenoic acid" RELATED [KEGG COMPOUND:] synonym: "12-Hydroxy-cis-9-octadecenoic acid" RELATED [KEGG COMPOUND:] synonym: "12-hydroxyoleic acid" RELATED [ChemIDplus:] synonym: "12-OH 9c-18:1" RELATED [ChEBI:] synonym: "C18H34O3" RELATED FORMULA [KEGG COMPOUND:] synonym: "CCCCCC[C@@H](O)C\\C=C/CCCCCCCC(O)=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C18H34O3/c1-2-3-4-11-14-17(19)15-12-9-7-5-6-8-10-13-16-18(20)21/h9,12,17,19H,2-8,10-11,13-16H2,1H3,(H,20,21)/b12-9-/t17-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=WBHHMMIMDMUBKC-QJWNTBNXSA-N" RELATED InChIKey [ChEBI:] synonym: "Ricinoleic acid" EXACT [KEGG COMPOUND:] synonym: "ricinolic acid" RELATED [ChemIDplus:] synonym: "Ricinolsaeure" RELATED [ChEBI:] xref: Beilstein:1727811 "Beilstein Registry Number" xref: ChemIDplus:141-22-0 "CAS Registry Number" xref: CiteXplore:18080873 "PubMed citation" xref: CiteXplore:19191319 "PubMed citation" xref: DrugBank:DB02955 "DrugBank" xref: KEGG COMPOUND:141-22-0 "CAS Registry Number" xref: KEGG COMPOUND:C08365 "KEGG COMPOUND" xref: KNApSAcK:C00001237 "KNApSAcK" xref: LIPID MAPS:LMFA01050233 "LIPID MAPS instance" xref: Reaxys:1727811 "Reaxys Registry Number" is_a: CHEBI:15904 ! long-chain fatty acid is_a: CHEBI:24654 ! hydroxy fatty acid is_a: CHEBI:25413 ! monounsaturated fatty acid is_a: CHEBI:59202 ! straight-chain fatty acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:28593 name: quinidine namespace: chebi_ontology alt_id: CHEBI:127150 alt_id: CHEBI:26494 alt_id: CHEBI:355477 alt_id: CHEBI:529982 alt_id: CHEBI:595841 alt_id: CHEBI:597286 alt_id: CHEBI:604323 alt_id: CHEBI:8719 def: "A cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy." [] synonym: "(+)-Quinidine" RELATED [KEGG COMPOUND:] synonym: "(+)-quinidine" RELATED [ChemIDplus:] synonym: "(8R,9S)-quinidine" RELATED [ChemIDplus:] synonym: "(9S)-6'-methoxycinchonan-9-ol" EXACT IUPAC_NAME [IUPAC:] synonym: "(R)-(6-methoxyquinolin-4-yl)((3S,4R,7S)-3-vinylquinuclidin-7-yl)methanol" RELATED [ChEMBL:] synonym: "(S)-(6-Methoxy-quinolin-4-yl)-((2R,5R)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol" RELATED [ChEMBL:] synonym: "(S)-(6-methoxyquinolin-4-yl)((2R,5R)-5-vinylquinuclidin-2-yl)methanol" RELATED [ChEMBL:] synonym: "6-methoxy-alpha-(5-vinyl-2-quinuclidinyl)-4-quinolinemethanol" RELATED [NIST Chemistry WebBook:] synonym: "[H][C@@]1(C[C@@H]2CC[N@]1C[C@@H]2C=C)[C@@H](O)c1ccnc2ccc(OC)cc12" RELATED SMILES [ChEBI:] synonym: "alpha-(6-methoxy-4-quinolyl)-5-vinyl-2-quinuclidinemethanol" RELATED [NIST Chemistry WebBook:] synonym: "beta-quinine" RELATED [NIST Chemistry WebBook:] synonym: "C20H24N2O2" RELATED FORMULA [ChEBI:] synonym: "C20H24N2O2" RELATED FORMULA [KEGG COMPOUND:] synonym: "Chinidin" RELATED [ChemIDplus:] synonym: "chinidinum" RELATED [ChEBI:] synonym: "CIN-QUIN" RELATED [ChEMBL:] synonym: "Conchinin" RELATED [ChemIDplus:] synonym: "conquinine" RELATED [ChemIDplus:] synonym: "InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19+,20-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=LOUPRKONTZGTKE-LHHVKLHASA-N" RELATED InChIKey [ChEBI:] synonym: "Kinidin" RELATED BRAND_NAME [KEGG DRUG:] synonym: "pitayine" RELATED [ChemIDplus:] synonym: "quinidina" RELATED [ChEBI:] synonym: "Quinidine" EXACT [KEGG COMPOUND:] synonym: "quinidine" EXACT [ChEMBL:] xref: Beilstein:91866 "Beilstein Registry Number" xref: ChEMBL:12477351 "PubMed citation" xref: ChEMBL:12699389 "PubMed citation" xref: ChEMBL:14971904 "PubMed citation" xref: ChEMBL:15225721 "PubMed citation" xref: ChEMBL:15270556 "PubMed citation" xref: ChEMBL:16570918 "PubMed citation" xref: ChEMBL:17132069 "PubMed citation" xref: ChEMBL:17228875 "PubMed citation" xref: ChEMBL:17870541 "PubMed citation" xref: ChEMBL:18324762 "PubMed citation" xref: ChEMBL:18395298 "PubMed citation" xref: ChEMBL:18788725 "PubMed citation" xref: ChemIDplus:56-54-2 "CAS Registry Number" xref: CiteXplore:14973303 "PubMed citation" xref: CiteXplore:15089813 "PubMed citation" xref: CiteXplore:15328252 "PubMed citation" xref: CiteXplore:17249648 "PubMed citation" xref: CiteXplore:23861085 "PubMed citation" xref: CiteXplore:24130427 "PubMed citation" xref: CiteXplore:445303 "PubMed citation" xref: CiteXplore:8337232 "PubMed citation" xref: CiteXplore:9864343 "PubMed citation" xref: DrugBank:DB00908 "DrugBank" xref: KEGG COMPOUND:56-54-2 "CAS Registry Number" xref: KEGG COMPOUND:C06527 "KEGG COMPOUND" xref: KEGG DRUG:D08458 "KEGG DRUG" xref: NIST Chemistry WebBook:56-54-2 "CAS Registry Number" xref: Reaxys:91866 "Reaxys Registry Number" is_a: CHEBI:51323 ! cinchona alkaloid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:28741 name: sodium fluoride namespace: chebi_ontology alt_id: CHEBI:26713 alt_id: CHEBI:9178 def: "A metal fluoride salt with a Na(+) counterion." [] synonym: "[F-].[Na+]" RELATED SMILES [ChEBI:] synonym: "FNa" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/FH.Na/h1H;/q;+1/p-1" RELATED InChI [ChEBI:] synonym: "InChIKey=PUZPDOWCWNUUKD-UHFFFAOYSA-M" RELATED InChIKey [ChEBI:] synonym: "Na.F" RELATED FORMULA [KEGG COMPOUND:] synonym: "NaF" RELATED [IUPAC:] synonym: "Sodium fluoride" EXACT [KEGG COMPOUND:] synonym: "sodium fluoride" EXACT IUPAC_NAME [IUPAC:] xref: ChemIDplus:7681-49-4 "CAS Registry Number" xref: KEGG COMPOUND:7681-49-4 "CAS Registry Number" xref: KEGG COMPOUND:C08142 "KEGG COMPOUND" xref: KEGG DRUG:D00943 "KEGG DRUG" xref: Wikipedia:Sodium_Fluoride "Wikipedia" is_a: CHEBI:24060 ! fluoride salt property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:28748 name: doxorubicin namespace: chebi_ontology alt_id: CHEBI:22270 alt_id: CHEBI:2496 alt_id: CHEBI:42031 def: "An anthracycline antibiotic that has formula C27H29NO11." [] synonym: "(1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside" EXACT IUPAC_NAME [IUPAC:] synonym: "(1S,3S)-3-glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside" RELATED [ChEBI:] synonym: "(8S-cis)-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione" RELATED [ChemIDplus:] synonym: "14-hydroxydaunomycin" RELATED [ChemIDplus:] synonym: "14-hydroxydaunorubicine" RELATED [ChemIDplus:] synonym: "Adriamycin" RELATED [KEGG COMPOUND:] synonym: "C27H29NO11" RELATED FORMULA [KEGG COMPOUND:] synonym: "COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO" RELATED SMILES [ChEBI:] synonym: "DOXORUBICIN" EXACT [PDBeChem:] synonym: "Doxorubicin" EXACT [KEGG COMPOUND:] synonym: "doxorubicin" RELATED INN [ChemIDplus:] synonym: "doxorubicine" RELATED INN [ChemIDplus:] synonym: "doxorubicinum" RELATED INN [ChemIDplus:] synonym: "InChI=1S/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t10-,13-,15-,17-,22+,27-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=AOJJSUZBOXZQNB-TZSSRYMLSA-N" RELATED InChIKey [ChEBI:] xref: ChemIDplus:23214-92-8 "CAS Registry Number" xref: DrugBank:DB00997 "DrugBank" xref: KEGG COMPOUND:23214-92-8 "CAS Registry Number" xref: KEGG COMPOUND:C01661 "KEGG COMPOUND" xref: KEGG DRUG:D03899 "KEGG DRUG" xref: LIPID MAPS:LMPK13050001 "LIPID MAPS instance" xref: PDBeChem:DM2 "PDBeChem" is_a: CHEBI:35315 ! deoxy hexoside is_a: CHEBI:36141 ! quinone is_a: CHEBI:47779 ! aminoglycoside is_a: CHEBI:49322 ! anthracycline antibiotic property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:28749 name: aryl beta-D-glucoside namespace: chebi_ontology alt_id: CHEBI:13824 alt_id: CHEBI:22641 alt_id: CHEBI:2858 def: "A beta-D-glucoside that has formula .." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "an aryl beta-D-glucoside" RELATED [UniProt:] synonym: "Aryl beta-D-glucoside" EXACT [KEGG COMPOUND:] synonym: "aryl beta-D-glucoside" EXACT [ChEBI:] synonym: "aryl beta-D-glucosides" RELATED [ChEBI:] synonym: "InChI=1S/C12H16O6/c13-6-8-9(14)10(15)11(16)12(18-8)17-7-4-2-1-3-5-7/h1-5,8-16H,6H2/t8-,9-,10+,11-,12-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=NEZJDVYDSZTRFS-RMPHRYRLSA-N" RELATED InChIKey [ChEBI:] synonym: "OC[C@H]1O[C@@H](Oc2ccccc2)[C@H](O)[C@@H](O)[C@@H]1O" RELATED SMILES [ChEBI:] xref: KEGG COMPOUND:C03097 "KEGG COMPOUND" is_a: CHEBI:22798 ! beta-D-glucoside property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:28757 name: fructose namespace: chebi_ontology alt_id: CHEBI:24104 alt_id: CHEBI:24110 alt_id: CHEBI:5172 def: "A ketohexose that is an isomer of glucose." [] synonym: "arabino-hex-2-ulose" EXACT IUPAC_NAME [IUPAC:] synonym: "arabino-Hexulose" RELATED [KEGG COMPOUND:] synonym: "C6H12O6" RELATED FORMULA [ChEBI:] synonym: "Fru" RELATED [JCBN:] synonym: "Fruchtzucker" RELATED [ChEBI:] synonym: "Fructose" EXACT [KEGG COMPOUND:] synonym: "fructose" EXACT IUPAC_NAME [IUPAC:] synonym: "Fruktose" RELATED [ChEBI:] xref: ChemIDplus:30237-26-4 "CAS Registry Number" xref: DrugBank:DB04173 "DrugBank" xref: KEGG COMPOUND:C01496 "KEGG COMPOUND" xref: Wikipedia:Fructose "Wikipedia" is_a: CHEBI:24973 ! ketohexose property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:28765 name: phosphatidylinositol phosphate namespace: chebi_ontology alt_id: CHEBI:26037 alt_id: CHEBI:26038 alt_id: CHEBI:8135 def: "Any member of the phosphoinositide family of compounds, of which seven occur naturally." [] synonym: "phosphatidylinositol phosphates" RELATED [ChEBI:] xref: CiteXplore:16441841 "PubMed citation" xref: CiteXplore:2538726 "PubMed citation" is_a: CHEBI:18179 ! phosphoinositide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:28793 name: beta-D-glucan namespace: chebi_ontology alt_id: CHEBI:10394 alt_id: CHEBI:22793 synonym: "beta-D-Glucan" EXACT [KEGG COMPOUND:] synonym: "beta-D-glucans" RELATED [ChEBI:] synonym: "beta-Glucan" RELATED [KEGG COMPOUND:] synonym: "C12H22O11(C6H10O5)n" RELATED FORMULA [KEGG COMPOUND:] xref: ChemIDplus:9041-22-9 "CAS Registry Number" xref: KEGG COMPOUND:9041-22-9 "CAS Registry Number" xref: KEGG COMPOUND:C00551 "KEGG COMPOUND" is_a: CHEBI:37163 ! glucan property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:28868 name: fatty acid anion namespace: chebi_ontology alt_id: CHEBI:13634 alt_id: CHEBI:24022 alt_id: CHEBI:4985 def: "The conjugate base of a fatty acid, arising from deprotonation of the carboxylic acid group of the corresponding fatty acid." [] synonym: "[O-]C([*])=O" RELATED SMILES [ChEBI:] synonym: "a fatty acid" RELATED [UniProt:] synonym: "acido graso anionico" RELATED [ChEBI:] synonym: "acidos grasos anionicos" RELATED [ChEBI:] synonym: "Alkanate" RELATED [KEGG COMPOUND:] synonym: "anion de l'acide gras" RELATED [ChEBI:] synonym: "CO2R" RELATED FORMULA [ChEBI:] synonym: "Fatty acid anion" EXACT [KEGG COMPOUND:] synonym: "fatty acid anions" RELATED [ChEBI:] synonym: "Fettsaeureanion" RELATED [ChEBI:] synonym: "Fettsaeureanionen" RELATED [ChEBI:] xref: CiteXplore:18628202 "PubMed citation" xref: KEGG COMPOUND:C02403 "KEGG COMPOUND" is_a: CHEBI:18059 ! lipid is_a: CHEBI:35757 ! monocarboxylic acid anion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:28869 name: menadione namespace: chebi_ontology alt_id: CHEBI:27304 alt_id: CHEBI:46306 alt_id: CHEBI:6747 def: "A naphthoquinone having a methyl substituent at the 2-position." [] synonym: "2-methyl-1,4-naphthalenedione" RELATED [ChemIDplus:] synonym: "2-Methyl-1,4-naphthochinon" RELATED [ChemIDplus:] synonym: "2-Methyl-1,4-naphthoquinone" RELATED [KEGG COMPOUND:] synonym: "2-methylnaphthalene-1,4-dione" EXACT IUPAC_NAME [IUPAC:] synonym: "C11H8O2" RELATED FORMULA [KEGG COMPOUND:] synonym: "CC1=CC(=O)c2ccccc2C1=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3" RELATED InChI [ChEBI:] synonym: "InChIKey=MJVAVZPDRWSRRC-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "MENADIONE" EXACT [PDBeChem:] synonym: "Menadione" EXACT [KEGG COMPOUND:] synonym: "menadione" EXACT [UniProt:] synonym: "Vitamin K3" RELATED [KEGG COMPOUND:] xref: ChemIDplus:58-27-5 "CAS Registry Number" xref: CiteXplore:15052609 "PubMed citation" xref: CiteXplore:16469140 "PubMed citation" xref: CiteXplore:1650428 "PubMed citation" xref: DrugBank:DB00170 "DrugBank" xref: HMDB:HMDB01892 "HMDB" xref: KEGG COMPOUND:58-27-5 "CAS Registry Number" xref: KEGG COMPOUND:C05377 "KEGG COMPOUND" xref: KEGG DRUG:D02335 "KEGG DRUG" xref: NIST Chemistry WebBook:58-27-5 "CAS Registry Number" xref: PDBeChem:VK3 "PDBeChem" xref: Reaxys:1908453 "Reaxys Registry Number" xref: Wikipedia:Menadione "Wikipedia" is_a: CHEBI:25481 ! naphthoquinone property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:28874 name: phosphatidylinositol namespace: chebi_ontology alt_id: CHEBI:18877 alt_id: CHEBI:494 def: "Any glycerophosphoinositol having one phosphatidyl group esterified to one of the hydroxy groups of inositol." [] synonym: "1,2-Diacyl-sn-glycero-3-phosphoinositol" RELATED [KEGG COMPOUND:] synonym: "1,2-diacyl-sn-glycero-3-phosphoinositol" RELATED [ChEBI:] synonym: "C11H17O13PR2" RELATED FORMULA [KEGG COMPOUND:] synonym: "phosphatidylinositols" RELATED [ChEBI:] synonym: "PI" RELATED [ChEBI:] synonym: "PtdIns" RELATED [ChEBI:] xref: CiteXplore:15634688 "PubMed citation" xref: CiteXplore:15967713 "PubMed citation" xref: CiteXplore:17417879 "PubMed citation" xref: CiteXplore:18189424 "PubMed citation" xref: CiteXplore:19456874 "PubMed citation" xref: CiteXplore:23015060 "PubMed citation" xref: CiteXplore:23118092 "PubMed citation" xref: DrugBank:DB02144 "DrugBank" xref: KEGG COMPOUND:C04436 "KEGG COMPOUND" xref: Wikipedia:Phosphatidylinositol "Wikipedia" is_a: CHEBI:36315 ! glycerophosphoinositol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:28938 name: ammonium namespace: chebi_ontology alt_id: CHEBI:22534 alt_id: CHEBI:49783 alt_id: CHEBI:7435 def: "An onium cation obtained by protonation of ammonia." [] synonym: "[H][N+]([H])([H])[H]" RELATED SMILES [ChEBI:] synonym: "[NH4](+)" RELATED [MolBase:] synonym: "ammonium" EXACT [ChEBI:] synonym: "ammonium" EXACT IUPAC_NAME [IUPAC:] synonym: "AMMONIUM ION" RELATED [PDBeChem:] synonym: "Ammonium(1+)" RELATED [ChemIDplus:] synonym: "azanium" EXACT IUPAC_NAME [IUPAC:] synonym: "H4N" RELATED FORMULA [KEGG COMPOUND:] synonym: "InChI=1S/H3N/h1H3/p+1" RELATED InChI [ChEBI:] synonym: "InChIKey=QGZKDVFQNNGYKY-UHFFFAOYSA-O" RELATED InChIKey [ChEBI:] synonym: "NH4(+)" RELATED [UniProt:] synonym: "NH4(+)" RELATED [IUPAC:] synonym: "NH4+" RELATED [KEGG COMPOUND:] xref: ChemIDplus:14798-03-9 "CAS Registry Number" xref: CiteXplore:11319011 "PubMed citation" xref: CiteXplore:11341317 "PubMed citation" xref: CiteXplore:12096804 "PubMed citation" xref: CiteXplore:14512268 "PubMed citation" xref: CiteXplore:14879753 "PubMed citation" xref: CiteXplore:16345391 "PubMed citation" xref: CiteXplore:16903292 "PubMed citation" xref: CiteXplore:17392693 "PubMed citation" xref: CiteXplore:18515490 "PubMed citation" xref: CiteXplore:19199063 "PubMed citation" xref: CiteXplore:19596600 "PubMed citation" xref: CiteXplore:19682559 "PubMed citation" xref: CiteXplore:19716251 "PubMed citation" xref: CiteXplore:21993530 "PubMed citation" xref: CiteXplore:22265469 "PubMed citation" xref: CiteXplore:22524020 "PubMed citation" xref: CiteXplore:22562341 "PubMed citation" xref: CiteXplore:22631217 "PubMed citation" xref: Gmelin:84 "Gmelin Registry Number" xref: KEGG COMPOUND:C01342 "KEGG COMPOUND" xref: MetaCyc:AMMONIUM "MetaCyc" xref: MolBase:929 "MolBase" xref: NIST Chemistry WebBook:14798-03-9 "CAS Registry Number" xref: PDBeChem:NH4 "PDBeChem" xref: Reaxys:16093784 "Reaxys Registry Number" xref: Wikipedia:Ammonium "Wikipedia" is_a: CHEBI:35106 ! nitrogen hydride is_a: CHEBI:35274 ! ammonium ion is_a: CHEBI:50313 ! onium cation is_a: CHEBI:60242 ! monovalent inorganic cation property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:28965 name: dicarboxylic acid dianion namespace: chebi_ontology alt_id: CHEBI:13632 alt_id: CHEBI:23688 alt_id: CHEBI:23689 alt_id: CHEBI:38711 def: "A carboxylic acid dianion obtained by deprotonation of both carboxy groups of any dicarboxylic acid." [] synonym: "[O-]C(=O)[*]C([O-])=O" RELATED SMILES [ChEBI:] synonym: "a dicarboxylate" RELATED [UniProt:] synonym: "C2O4R" RELATED FORMULA [ChEBI:] synonym: "dicarboxylate" RELATED [ChEBI:] synonym: "dicarboxylates" RELATED [ChEBI:] synonym: "dicarboxylic acid dianion" EXACT [ChEBI:] synonym: "dicarboxylic acid dianions" RELATED [ChEBI:] is_a: CHEBI:35693 ! dicarboxylic acid anion is_a: CHEBI:38716 ! carboxylic acid dianion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:29014 name: cordycepin namespace: chebi_ontology alt_id: CHEBI:19841 alt_id: CHEBI:3881 def: "A 3'-deoxyribonucleoside that has formula C10H13N5O3." [] synonym: "3'-deoxyadenosine" EXACT IUPAC_NAME [IUPAC:] synonym: "3'-deoxyadenosine" RELATED [ChEBI:] synonym: "9-(beta-D-3'-Deoxyribofuranosyl)adenine" RELATED [ChemIDplus:] synonym: "9-Cordyceposidoadenine" RELATED [ChemIDplus:] synonym: "9H-Purine, 6-amino-9-(3-deoxy-beta-D-ribofuranosyl)-" RELATED [ChemIDplus:] synonym: "C10H13N5O3" RELATED FORMULA [ChEBI:] synonym: "Cordycepin" EXACT [KEGG COMPOUND:] synonym: "cordycepin" EXACT [ChEBI:] synonym: "Cordycepine" RELATED [ChemIDplus:] synonym: "InChI=1S/C10H13N5O3/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(17)1-5(2-16)18-10/h3-6,10,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,10+/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=OFEZSBMBBKLLBJ-BAJZRUMYSA-N" RELATED InChIKey [ChEBI:] synonym: "Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)C[C@H]1O" RELATED SMILES [ChEBI:] xref: Beilstein:0035194 "Beilstein Registry Number" xref: ChemIDplus:73-03-0 "CAS Registry Number" xref: KEGG COMPOUND:C08431 "KEGG COMPOUND" xref: KNApSAcK:C00001495 "KNApSAcK" xref: PDBeChem:3AD "PDBeChem" is_a: CHEBI:22260 ! adenosines is_a: CHEBI:36987 ! 3'-deoxyribonucleoside property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:29016 name: arginine namespace: chebi_ontology alt_id: CHEBI:22616 alt_id: CHEBI:2643 def: "An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group." [] synonym: "2-amino-5-(carbamimidamido)pentanoic acid" RELATED [IUPAC:] synonym: "2-amino-5-guanidinopentanoic acid" RELATED [JCBN:] synonym: "2-Amino-5-guanidinovaleric acid" RELATED [KEGG COMPOUND:] synonym: "Arginin" RELATED [ChEBI:] synonym: "Arginine" EXACT [KEGG COMPOUND:] synonym: "arginine" EXACT IUPAC_NAME [IUPAC:] synonym: "C6H14N4O2" RELATED FORMULA [KEGG COMPOUND:] synonym: "Harg" RELATED [IUPAC:] synonym: "InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)" RELATED InChI [ChEBI:] synonym: "InChIKey=ODKSFYDXXFIFQN-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "NC(CCCNC(N)=N)C(O)=O" RELATED SMILES [ChEBI:] xref: Beilstein:1725411 "Beilstein Registry Number" xref: ChemIDplus:7200-25-1 "CAS Registry Number" xref: CiteXplore:10848923 "PubMed citation" xref: KEGG COMPOUND:C02385 "KEGG COMPOUND" xref: Reaxys:1725411 "Reaxys Registry Number" xref: Wikipedia:L-Arginine "Wikipedia" is_a: CHEBI:24436 ! guanidines is_a: CHEBI:33704 ! alpha-amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:29067 name: carboxylic acid anion namespace: chebi_ontology alt_id: CHEBI:13626 alt_id: CHEBI:13945 alt_id: CHEBI:23026 alt_id: CHEBI:58657 def: "The conjugate base formed when the carboxy group of a carboxylic acid is deprotonated." [] synonym: "[O-]C([*])=O" RELATED SMILES [ChEBI:] synonym: "a carboxylate" RELATED [UniProt:] synonym: "carboxylic acid anions" RELATED [ChEBI:] synonym: "carboxylic anions" RELATED [ChEBI:] synonym: "CO2R" RELATED FORMULA [ChEBI:] is_a: CHEBI:25696 ! organic anion is_a: CHEBI:35406 ! oxoanion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:29075 name: mononucleotide namespace: chebi_ontology alt_id: CHEBI:14616 alt_id: CHEBI:25404 alt_id: CHEBI:6983 synonym: "C5H10O7PR" RELATED FORMULA [KEGG COMPOUND:] synonym: "Mononucleotide" EXACT [KEGG COMPOUND:] synonym: "mononucleotide" EXACT [UniProt:] synonym: "mononucleotides" RELATED [ChEBI:] synonym: "O[C@H]1[C@H]([*])O[C@H](COP(O)(O)=O)[C@H]1O" RELATED SMILES [ChEBI:] xref: KEGG COMPOUND:C02171 "KEGG COMPOUND" is_a: CHEBI:36976 ! nucleotide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:29103 name: potassium(1+) namespace: chebi_ontology alt_id: CHEBI:26219 alt_id: CHEBI:49685 alt_id: CHEBI:8345 def: "A monoatomic monocation obtained from potassium." [] synonym: "[K+]" RELATED SMILES [ChEBI:] synonym: "InChI=1S/K/q+1" RELATED InChI [ChEBI:] synonym: "InChIKey=NPYPAHLBTDXSSS-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "K" RELATED FORMULA [KEGG COMPOUND:] synonym: "K(+)" RELATED [IUPAC:] synonym: "K(+)" RELATED [UniProt:] synonym: "K+" RELATED [KEGG COMPOUND:] synonym: "potassium" RELATED [PDBeChem:] synonym: "potassium cation" EXACT IUPAC_NAME [IUPAC:] synonym: "POTASSIUM ION" RELATED [PDBeChem:] synonym: "potassium(1+)" EXACT IUPAC_NAME [IUPAC:] synonym: "potassium(1+) ion" EXACT IUPAC_NAME [IUPAC:] synonym: "potassium(I) cation" EXACT IUPAC_NAME [IUPAC:] xref: Gmelin:15203 "Gmelin Registry Number" xref: KEGG COMPOUND:C00238 "KEGG COMPOUND" xref: KEGG DRUG:D08403 "KEGG DRUG" xref: NIST Chemistry WebBook:24203-36-9 "CAS Registry Number" xref: PDBeChem:K "PDBeChem" is_a: CHEBI:25414 ! monoatomic monocation is_a: CHEBI:33504 ! alkali metal cation is_a: CHEBI:37247 ! elemental potassium is_a: CHEBI:60242 ! monovalent inorganic cation property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:29108 name: calcium(2+) namespace: chebi_ontology alt_id: CHEBI:22988 alt_id: CHEBI:3308 alt_id: CHEBI:48760 def: "A calcium cation that has formula Ca." [] synonym: "[Ca++]" RELATED SMILES [ChEBI:] synonym: "Ca" RELATED FORMULA [KEGG COMPOUND:] synonym: "Ca(2+)" RELATED [UniProt:] synonym: "Ca(2+)" RELATED [IUPAC:] synonym: "Ca2+" RELATED [KEGG COMPOUND:] synonym: "calcium" RELATED [PDBeChem:] synonym: "CALCIUM ION" RELATED [PDBeChem:] synonym: "calcium(2+)" EXACT IUPAC_NAME [IUPAC:] synonym: "calcium(2+) ion" EXACT IUPAC_NAME [IUPAC:] synonym: "calcium(II) cation" EXACT IUPAC_NAME [IUPAC:] synonym: "calcium, doubly charged positive ion" RELATED [NIST Chemistry WebBook:] synonym: "InChI=1S/Ca/q+2" RELATED InChI [ChEBI:] synonym: "InChIKey=BHPQYMZQTOCNFJ-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] xref: ChemIDplus:14127-61-8 "CAS Registry Number" xref: Gmelin:6850 "Gmelin Registry Number" xref: KEGG COMPOUND:C00076 "KEGG COMPOUND" xref: NIST Chemistry WebBook:14127-61-8 "CAS Registry Number" xref: PDBeChem:CA "PDBeChem" is_a: CHEBI:30412 ! monoatomic dication is_a: CHEBI:39123 ! calcium cation is_a: CHEBI:60240 ! divalent metal cation property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:29222 name: hypochlorite namespace: chebi_ontology def: "A chlorine oxoanion that has formula ClO." [] synonym: "[ClO](-)" RELATED [IUPAC:] synonym: "[O-]Cl" RELATED SMILES [ChEBI:] synonym: "ClO" RELATED FORMULA [ChEBI:] synonym: "ClO(-)" RELATED [IUPAC:] synonym: "Hypochlorit" RELATED [ChEBI:] synonym: "hypochlorite" EXACT IUPAC_NAME [IUPAC:] synonym: "InChI=1S/ClO/c1-2/q-1" RELATED InChI [ChEBI:] synonym: "InChIKey=WQYVRQLZKVEZGA-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "oxidochlorate(1-)" EXACT IUPAC_NAME [IUPAC:] xref: ChemIDplus:14380-61-1 "CAS Registry Number" xref: Gmelin:682 "Gmelin Registry Number" xref: Wikipedia:Hypochlorite "Wikipedia" is_a: CHEBI:33437 ! chlorine oxoanion is_a: CHEBI:37750 ! chlorine oxide is_a: CHEBI:79389 ! monovalent inorganic anion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:29256 name: thiol namespace: chebi_ontology alt_id: CHEBI:13443 alt_id: CHEBI:13696 alt_id: CHEBI:17366 alt_id: CHEBI:26969 alt_id: CHEBI:8766 alt_id: CHEBI:9556 synonym: "a thiol" RELATED [UniProt:] synonym: "HSR" RELATED FORMULA [ChEBI:] synonym: "HSR" RELATED FORMULA [KEGG COMPOUND:] synonym: "Mercaptan" RELATED [KEGG COMPOUND:] synonym: "mercaptans" RELATED [ChEBI:] synonym: "Merkaptan" RELATED [ChEBI:] synonym: "RSH" RELATED [IUPAC:] synonym: "RSH" RELATED [KEGG COMPOUND:] synonym: "S[*]" RELATED SMILES [ChEBI:] synonym: "Thiol" EXACT [KEGG COMPOUND:] synonym: "thiols" EXACT IUPAC_NAME [IUPAC:] synonym: "thiols" RELATED [ChEBI:] xref: KEGG COMPOUND:C00145 "KEGG COMPOUND" xref: KEGG COMPOUND:C01336 "KEGG COMPOUND" xref: Wikipedia:Thiol "Wikipedia" is_a: CHEBI:33261 ! organosulfur compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:29281 name: alkyl sulfate namespace: chebi_ontology alt_id: CHEBI:13810 alt_id: CHEBI:22325 alt_id: CHEBI:2583 synonym: "Alkyl sulfate" EXACT [KEGG COMPOUND:] synonym: "alkyl sulfates" RELATED [ChEBI:] synonym: "HO4SR" RELATED FORMULA [KEGG COMPOUND:] synonym: "OS(=O)(=O)O[*]" RELATED SMILES [ChEBI:] xref: KEGG COMPOUND:C02000 "KEGG COMPOUND" is_a: CHEBI:25704 ! organic sulfate is_a: CHEBI:26819 ! sulfuric ester property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:29321 name: sodium nitroprusside namespace: chebi_ontology def: "An organic sodium salt that is the disodium salt of nitroprusside." [] synonym: "[Na+].[Na+].O=N[Fe--](C#N)(C#N)(C#N)(C#N)C#N" RELATED SMILES [ChEBI:] synonym: "C5FeN6Na2O" RELATED FORMULA [ChEBI:] synonym: "disodium pentacyanidonitrosylferrate" RELATED [IUPAC:] synonym: "InChI=1S/5CN.Fe.NO.2Na/c5*1-2;;1-2;;/q;;;;;2*-1;2*+1" RELATED InChI [ChEBI:] synonym: "InChIKey=FPWUWQVZUNFZQM-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "Na2[Fe(CN)5(NO)]" RELATED [IUPAC:] synonym: "Sodium nitroprusside anhydrous" RELATED [ChemIDplus:] synonym: "sodium pentacyanidonitrosylferrate(2-)" EXACT IUPAC_NAME [IUPAC:] synonym: "sodium pentacyanidonitrosylferrate(III)" EXACT IUPAC_NAME [IUPAC:] xref: ChemIDplus:14402-89-2 "CAS Registry Number" is_a: CHEBI:38700 ! organic sodium salt property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:29347 name: monocarboxylic acid amide namespace: chebi_ontology alt_id: CHEBI:13211 alt_id: CHEBI:22207 alt_id: CHEBI:25383 alt_id: CHEBI:6977 def: "A carboxamide derived from a monocarboxylic acid." [] synonym: "[*]N([*])C([*])=O" RELATED SMILES [ChEBI:] synonym: "acid amides" RELATED [ChEBI:] synonym: "CNOR3" RELATED FORMULA [ChEBI:] synonym: "Monocarboxylic acid amide" EXACT [KEGG COMPOUND:] synonym: "monocarboxylic acid amides" RELATED [ChEBI:] xref: ChEBI:C01658 "KEGG COMPOUND" xref: KEGG COMPOUND:C03620 "KEGG COMPOUND" is_a: CHEBI:37622 ! carboxamide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:29515 name: ansamitocin P3 namespace: chebi_ontology def: "A polyketide antibiotic that is isolated from Actinosynnema pretiosum and also exhibits antitumour activity." [] synonym: "(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1(10,14).0(3,5)]hexacosa-10(26),11,13,16,18-pentaen-6-yl 2-methylpropanoate" EXACT IUPAC_NAME [IUPAC:] synonym: "2'-De(acetylmethylamino)-2'-methylmaytansine" RELATED [KEGG COMPOUND:] synonym: "[H][C@@]12C[C@@](O)(NC(=O)O1)[C@H](OC)\\C=C\\C=C(C)\\Cc1cc(OC)c(Cl)c(c1)N(C)C(=O)C[C@H](OC(=O)C(C)C)[C@]1(C)O[C@@]1([H])[C@@H]2C" RELATED SMILES [ChEBI:] synonym: "ansamitocin P-3" RELATED [ChEBI:] synonym: "Ansamitocin P3" EXACT [KEGG COMPOUND:] synonym: "Ansamitosin P3" RELATED [KEGG COMPOUND:] synonym: "Antibiotic C15003P3" RELATED [KEGG COMPOUND:] synonym: "C15003P3" RELATED [KEGG COMPOUND:] synonym: "C32H43ClN2O9" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C32H43ClN2O9/c1-17(2)29(37)43-25-15-26(36)35(6)21-13-20(14-22(40-7)27(21)33)12-18(3)10-9-11-24(41-8)32(39)16-23(42-30(38)34-32)19(4)28-31(25,5)44-28/h9-11,13-14,17,19,23-25,28,39H,12,15-16H2,1-8H3,(H,34,38)/b11-9+,18-10+/t19-,23+,24-,25+,28+,31+,32+/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=OPQNCARIZFLNLF-JBHFWYGFSA-N" RELATED InChIKey [ChEBI:] synonym: "Maytansinol isobutyrate" RELATED [KEGG COMPOUND:] xref: ChemIDplus:66584-72-3 "CAS Registry Number" xref: CiteXplore:11071278 "PubMed citation" xref: CiteXplore:1517150 "PubMed citation" xref: CiteXplore:1530630 "PubMed citation" xref: CiteXplore:15533675 "PubMed citation" xref: CiteXplore:15674857 "PubMed citation" xref: CiteXplore:19609582 "PubMed citation" xref: CiteXplore:20235129 "PubMed citation" xref: CiteXplore:20980145 "PubMed citation" xref: CiteXplore:21504911 "PubMed citation" xref: CiteXplore:21907573 "PubMed citation" xref: CiteXplore:2298279 "PubMed citation" xref: KEGG COMPOUND:66584-72-3 "CAS Registry Number" xref: KEGG COMPOUND:C12045 "KEGG COMPOUND" xref: KNApSAcK:C00018269 "KNApSAcK" xref: LIPID MAPS:LMPK04000039 "LIPID MAPS instance" xref: Patent:US2007135629 "Patent" xref: Reaxys:5416580 "Reaxys Registry Number" is_a: CHEBI:23003 ! carbamate ester is_a: CHEBI:24995 ! lactam is_a: CHEBI:26188 ! polyketide is_a: CHEBI:32955 ! epoxide is_a: CHEBI:35618 ! aromatic ether is_a: CHEBI:51026 ! macrocycle is_a: CHEBI:83403 ! monochlorobenzenes property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:29699 name: tunicamycin namespace: chebi_ontology def: "A mixture of antiviral nucleoside antibiotics produced by Streptomyces lysosuperificus. It contains at least 10 homologues comprising uracil, N-acetylglucosamine, an 11-carbon aminodialdose called tunicamine, and a fatty acid linked to the amino group of the tunicamine. The homologues vary in the composition of the fatty acid moiety." [] synonym: "[H][C@@](O)(C[C@H]1O[C@@H](OC2O[C@H]([*]O)[C@@H](O)[C@H](O)[C@H]2NC(C)=O)[C@H](NC([*])=O)[C@@H](O)[C@H]1O)[C@@]1([H])O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O" RELATED SMILES [ChEBI:] synonym: "C25H38N4O16" RELATED FORMULA [ChEBI:] synonym: "Tunicamycin" EXACT [KEGG COMPOUND:] xref: ChemIDplus:11089-65-9 "CAS Registry Number" xref: CiteXplore:11478581 "PubMed citation" xref: CiteXplore:11514096 "PubMed citation" xref: CiteXplore:11732194 "PubMed citation" xref: CiteXplore:11798249 "PubMed citation" xref: CiteXplore:12093793 "PubMed citation" xref: CiteXplore:12106388 "PubMed citation" xref: CiteXplore:12136966 "PubMed citation" xref: CiteXplore:12232600 "PubMed citation" xref: CiteXplore:12232799 "PubMed citation" xref: CiteXplore:12515321 "PubMed citation" xref: CiteXplore:160437 "PubMed citation" xref: CiteXplore:1624425 "PubMed citation" xref: CiteXplore:3018444 "PubMed citation" xref: CiteXplore:315774 "PubMed citation" xref: CiteXplore:4624615 "PubMed citation" xref: CiteXplore:4630978 "PubMed citation" xref: CiteXplore:5103138 "PubMed citation" xref: CiteXplore:5103535 "PubMed citation" xref: CiteXplore:5168706 "PubMed citation" xref: CiteXplore:6153524 "PubMed citation" xref: CiteXplore:6813319 "PubMed citation" xref: CiteXplore:6975776 "PubMed citation" xref: CiteXplore:6992777 "PubMed citation" xref: CiteXplore:701277 "PubMed citation" xref: CiteXplore:7142115 "PubMed citation" xref: CiteXplore:7144800 "PubMed citation" xref: CiteXplore:7766032 "PubMed citation" xref: KEGG COMPOUND:11089-65-9 "CAS Registry Number" xref: KEGG COMPOUND:C12063 "KEGG COMPOUND" xref: Wikipedia:Tunicamycin "Wikipedia" is_a: CHEBI:60004 ! mixture property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:29987 name: glutamate(2-) namespace: chebi_ontology def: "A dicarboxylic acid dianion that is the conjugate base of glutamate(1-)." [] synonym: "2-aminopentanedioate" EXACT IUPAC_NAME [IUPAC:] synonym: "C5H7NO4" RELATED FORMULA [ChEBI:] synonym: "glutamate" EXACT IUPAC_NAME [IUPAC:] synonym: "glutamate(2-)" EXACT [JCBN:] synonym: "glutamic acid dianion" RELATED [JCBN:] synonym: "InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-2" RELATED InChI [ChEBI:] synonym: "InChIKey=WHUUTDBJXJRKMK-UHFFFAOYSA-L" RELATED InChIKey [ChEBI:] synonym: "NC(CCC([O-])=O)C([O-])=O" RELATED SMILES [ChEBI:] xref: Beilstein:4134100 "Beilstein Registry Number" xref: Gmelin:327903 "Gmelin Registry Number" xref: Reaxys:4134100 "Reaxys Registry Number" is_a: CHEBI:28965 ! dicarboxylic acid dianion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:29989 name: D-glutamate(2-) namespace: chebi_ontology def: "A glutamate(2-) that has formula C5H7NO4." [] synonym: "(2R)-2-aminopentanedioate" EXACT IUPAC_NAME [IUPAC:] synonym: "C5H7NO4" RELATED FORMULA [ChEBI:] synonym: "D-glutamate" EXACT IUPAC_NAME [IUPAC:] synonym: "D-glutamate(2-)" EXACT [JCBN:] synonym: "D-glutamic acid dianion" RELATED [JCBN:] synonym: "InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-2/t3-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=WHUUTDBJXJRKMK-GSVOUGTGSA-L" RELATED InChIKey [ChEBI:] synonym: "N[C@H](CCC([O-])=O)C([O-])=O" RELATED SMILES [ChEBI:] xref: Beilstein:8143000 "Beilstein Registry Number" xref: Gmelin:327904 "Gmelin Registry Number" is_a: CHEBI:29987 ! glutamate(2-) property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:29993 name: L-aspartate(2-) namespace: chebi_ontology def: "An aspartate(2-) that is the conjugate base of L-aspartate(1-)." [] synonym: "(2S)-2-aminobutanedioate" EXACT IUPAC_NAME [IUPAC:] synonym: "(2S)-2-aminosuccinate" RELATED [ChEBI:] synonym: "C4H5NO4" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=CKLJMWTZIZZHCS-REOHCLBHSA-L" RELATED InChIKey [ChEBI:] synonym: "L-aspartate" EXACT IUPAC_NAME [IUPAC:] synonym: "L-aspartate(2-)" EXACT [JCBN:] synonym: "L-aspartic acid dianion" RELATED [JCBN:] synonym: "N[C@@H](CC([O-])=O)C([O-])=O" RELATED SMILES [ChEBI:] xref: Beilstein:4133557 "Beilstein Registry Number" xref: Gmelin:327367 "Gmelin Registry Number" xref: Reaxys:4133557 "Reaxys Registry Number" is_a: CHEBI:29995 ! aspartate(2-) is_a: CHEBI:59814 ! L-alpha-amino acid anion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:29995 name: aspartate(2-) namespace: chebi_ontology def: "A C4-dicarboxylate that is the dianion obtained by the deprotonation of both the carboxy groups of aspartic acid." [] synonym: "2-aminobutanedioate" EXACT IUPAC_NAME [IUPAC:] synonym: "2-aminosuccinate" RELATED [ChEBI:] synonym: "aspartate" EXACT IUPAC_NAME [IUPAC:] synonym: "aspartate(2-)" EXACT [JCBN:] synonym: "aspartic acid dianion" RELATED [JCBN:] synonym: "C4H5NO4" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-2" RELATED InChI [ChEBI:] synonym: "InChIKey=CKLJMWTZIZZHCS-UHFFFAOYSA-L" RELATED InChIKey [ChEBI:] synonym: "NC(CC([O-])=O)C([O-])=O" RELATED SMILES [ChEBI:] is_a: CHEBI:33558 ! alpha-amino-acid anion is_a: CHEBI:61336 ! C4-dicarboxylate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:30089 name: acetate namespace: chebi_ontology alt_id: CHEBI:13704 alt_id: CHEBI:22165 alt_id: CHEBI:40480 def: "A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of acetic acid." [] synonym: "acetate" EXACT [UniProt:] synonym: "acetate" EXACT [PDBeChem:] synonym: "acetate" EXACT IUPAC_NAME [IUPAC:] synonym: "ACETATE ION" RELATED [PDBeChem:] synonym: "acetic acid, ion(1-)" RELATED [ChemIDplus:] synonym: "Azetat" RELATED [ChEBI:] synonym: "C2H3O2" RELATED FORMULA [ChEBI:] synonym: "CC([O-])=O" RELATED SMILES [ChEBI:] synonym: "CH3-COO(-)" RELATED [IUPAC:] synonym: "Ethanoat" RELATED [ChEBI:] synonym: "ethanoate" RELATED [ChEBI:] synonym: "InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1" RELATED InChI [ChEBI:] synonym: "InChIKey=QTBSBXVTEAMEQO-UHFFFAOYSA-M" RELATED InChIKey [ChEBI:] synonym: "MeCO2 anion" RELATED [NIST Chemistry WebBook:] xref: Beilstein:1901470 "Beilstein Registry Number" xref: ChEBI:C00033 "KEGG COMPOUND" xref: ChEBI:c0050 "UM-BBD compID" xref: ChemIDplus:71-50-1 "CAS Registry Number" xref: CiteXplore:17190852 "PubMed citation" xref: CiteXplore:22211106 "PubMed citation" xref: CiteXplore:22371380 "PubMed citation" xref: DrugBank:DB03166 "DrugBank" xref: Gmelin:1379 "Gmelin Registry Number" xref: MetaCyc:ACET "MetaCyc" xref: NIST Chemistry WebBook:71-50-1 "CAS Registry Number" xref: PDBeChem:ACT "PDBeChem" xref: Reaxys:1901470 "Reaxys Registry Number" xref: Wikipedia:Acetate "Wikipedia" is_a: CHEBI:35757 ! monocarboxylic acid anion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:3015 name: benomyl namespace: chebi_ontology def: "A member of the class of benzimidazoles that is the methyl ester of [1-(butylcarbamoyl)-1H-benzimidazol-2-yl]carbamic acid. A foliar fungicide used to control a wide range of Ascomycetes and Fungi Imperfecti in a wide range of crops." [] synonym: "1-(Butylcarbamoyl)-2-benzimidazol-methylcarbamat" RELATED [ChemIDplus:] synonym: "1-(Butylcarbamoyl)-2-benzimidazolecarbamic acid, methyl ester" RELATED [ChemIDplus:] synonym: "1-(N-Butylcarbamoyl)-2-(methoxy-carboxamido)-benzimidazol" RELATED [ChemIDplus:] synonym: "Benlate" RELATED [KEGG COMPOUND:] synonym: "Benomyl" EXACT [KEGG COMPOUND:] synonym: "C14H18N4O3" RELATED FORMULA [ChEBI:] synonym: "CCCCNC(=O)n1c(NC(=O)OC)nc2ccccc12" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C14H18N4O3/c1-3-4-9-15-13(19)18-11-8-6-5-7-10(11)16-12(18)17-14(20)21-2/h5-8H,3-4,9H2,1-2H3,(H,15,19)(H,16,17,20)" RELATED InChI [ChEBI:] synonym: "InChIKey=RIOXQFHNBCKOKP-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "Methyl 1-(butylamino)carbonyl-1H-benzimidazol-2-ylcarbamate" RELATED [HMDB:] synonym: "Methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate" RELATED [HMDB:] synonym: "methyl [1-(butylcarbamoyl)-1H-benzimidazol-2-yl]carbamate" EXACT IUPAC_NAME [IUPAC:] synonym: "Methyl N-(1-butylcarbamoyl-2-benzimidazole)carbamate" RELATED [HMDB:] xref: Alan Wood's Pesticides:benomyl "Pesticides" xref: Beilstein:825455 "Beilstein Registry Number" xref: ChemIDplus:17804-35-2 "CAS Registry Number" xref: CiteXplore:15813220 "PubMed citation" xref: CiteXplore:16903866 "PubMed citation" xref: CiteXplore:19049291 "PubMed citation" xref: CiteXplore:24693254 "PubMed citation" xref: CiteXplore:24782104 "PubMed citation" xref: CiteXplore:25045800 "PubMed citation" xref: CiteXplore:25104429 "PubMed citation" xref: CiteXplore:25145128 "PubMed citation" xref: HMDB:HMDB31767 "HMDB" xref: KEGG COMPOUND:17804-35-2 "CAS Registry Number" xref: KEGG COMPOUND:C10896 "KEGG COMPOUND" xref: NIST Chemistry WebBook:17804-35-2 "CAS Registry Number" xref: Reaxys:825455 "Reaxys Registry Number" xref: Wikipedia:Benomyl "Wikipedia" is_a: CHEBI:22715 ! benzimidazoles is_a: CHEBI:23003 ! carbamate ester is_a: CHEBI:62733 ! aromatic amide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:30199 name: trioxidosilicate(.1-) namespace: chebi_ontology def: "A silicon oxide that has formula O3Si." [] synonym: "[O][Si]([O-])=O" RELATED SMILES [ChEBI:] synonym: "[SiO3](.-)" RELATED [ChEBI:] synonym: "InChI=1S/O3Si/c1-4(2)3/q-1" RELATED InChI [ChEBI:] synonym: "InChIKey=MBOHKLZBATVDTL-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "O3Si" RELATED FORMULA [ChEBI:] synonym: "SiO3 radical anion" RELATED [NIST Chemistry WebBook:] synonym: "SiO3(.-)" RELATED [IUPAC:] synonym: "trioxidosilicate(.1-)" EXACT IUPAC_NAME [IUPAC:] is_a: CHEBI:33327 ! silicon oxide is_a: CHEBI:36876 ! inorganic radical anion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:30412 name: monoatomic dication namespace: chebi_ontology alt_id: CHEBI:23856 alt_id: CHEBI:4665 synonym: "." RELATED FORMULA [ChEBI:] synonym: "[*++]" RELATED SMILES [ChEBI:] synonym: "Divalent cation" RELATED [KEGG COMPOUND:] synonym: "divalent cation" RELATED [UniProt:] synonym: "divalent inorganic cations" RELATED [ChEBI:] synonym: "monoatomic dications" RELATED [ChEBI:] xref: KEGG COMPOUND:C00572 "KEGG COMPOUND" is_a: CHEBI:23906 ! monoatomic cation property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:30528 name: vanadium oxoanion namespace: chebi_ontology alt_id: CHEBI:27272 alt_id: CHEBI:35167 alt_id: CHEBI:9929 synonym: "." RELATED FORMULA [ChEBI:] synonym: "Vanadate" RELATED [KEGG COMPOUND:] synonym: "vanadium oxoanion" EXACT [ChEBI:] synonym: "vanadium oxoanions" RELATED [ChEBI:] xref: KEGG COMPOUND:C00754 "KEGG COMPOUND" is_a: CHEBI:35166 ! vanadium coordination entity is_a: CHEBI:35405 ! transition element oxoanion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:30740 name: ethylene glycol bis(2-aminoethyl)tetraacetic acid namespace: chebi_ontology def: "A tetracarboxylic acid that has formula C14H24N2O10." [] synonym: "2,2',2'',2'''-[ethane-1,2-diylbis(oxyethane-2,1-diylnitrilo)]tetraacetic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "3,12-bis(carboxymethyl)-6,9-dioxa-3,12-diazatetradecanedioic acid" RELATED [ChemIDplus:] synonym: "[ethylenebis(oxyethylenenitrilo)]tetraacetic acid" RELATED [ChEBI:] synonym: "C14H24N2O10" RELATED FORMULA [ChEBI:] synonym: "EGTA" RELATED [ChemIDplus:] synonym: "Egtazic acid" RELATED [ChemIDplus:] synonym: "ethylene glycol bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid" RELATED [ChEBI:] synonym: "ethylene glycol-O,O'-bis(2-aminoethyl)-N,N,N',N'-tetraacetic acid" RELATED [ChEBI:] synonym: "H4egta" RELATED [IUPAC:] synonym: "InChI=1S/C14H24N2O10/c17-11(18)7-15(8-12(19)20)1-3-25-5-6-26-4-2-16(9-13(21)22)10-14(23)24/h1-10H2,(H,17,18)(H,19,20)(H,21,22)(H,23,24)" RELATED InChI [ChEBI:] synonym: "InChIKey=DEFVIWRASFVYLL-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "OC(=O)CN(CCOCCOCCN(CC(O)=O)CC(O)=O)CC(O)=O" RELATED SMILES [ChEBI:] xref: Beilstein:1717370 "Beilstein Registry Number" xref: ChemIDplus:67-42-5 "CAS Registry Number" xref: Gmelin:234970 "Gmelin Registry Number" is_a: CHEBI:35742 ! tetracarboxylic acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:30879 name: alcohol namespace: chebi_ontology alt_id: CHEBI:13804 alt_id: CHEBI:22288 alt_id: CHEBI:2553 def: "A compound in which a hydroxy group, -OH, is attached to a saturated carbon atom." [] synonym: "Alcohol" EXACT [KEGG COMPOUND:] synonym: "alcohols" EXACT IUPAC_NAME [IUPAC:] synonym: "an alcohol" RELATED [UniProt:] synonym: "HOR" RELATED FORMULA [ChEBI:] synonym: "O[*]" RELATED SMILES [ChEBI:] xref: KEGG COMPOUND:C00069 "KEGG COMPOUND" is_a: CHEBI:33822 ! organic hydroxy compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:30911 name: glucitol namespace: chebi_ontology alt_id: CHEBI:15093 alt_id: CHEBI:26724 alt_id: CHEBI:26726 alt_id: CHEBI:33795 alt_id: CHEBI:33796 alt_id: CHEBI:9201 synonym: "C6H14O6" RELATED FORMULA [ChEBI:] synonym: "glucitol" EXACT IUPAC_NAME [IUPAC:] synonym: "gulitol" RELATED [ChEBI:] synonym: "rel-(2R,3R,4R,5S)-hexane-1,2,3,4,5,6-hexol" RELATED [IUPAC:] synonym: "Sorbitol" RELATED [KEGG COMPOUND:] synonym: "sorbitol" RELATED [UniProt:] synonym: "sorbitols" RELATED [ChEBI:] xref: Beilstein:1721909 "Beilstein Registry Number" xref: Gmelin:83165 "Gmelin Registry Number" xref: Wikipedia:Sorbitol "Wikipedia" is_a: CHEBI:24583 ! hexitol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:315019 name: cilofungin namespace: chebi_ontology def: "A cyclic hexapeptide echinocandin antibiotic isolated from Aspergillus spp. By inhibiting the conversion of lanosterol to ergosterol, it invades a fungus' ability to synthesize cell walls. A modified form of echinocandin B, it is an antimycotic agent against Candida albicans." [] synonym: "5.1:6-anhydro{(4R,5R)-4,5-dihydroxy-N(2)-[4-(octyloxy)benzoyl]-L-ornithyl-L-threonyl-(4R)-4-hydroxy-L-prolyl-(4S)-4-hydroxy-4-(4-hydroxyphenyl)-L-threonyl-L-threonyl-(3S,4S)-3-hydroxy-4-methyl-L-proline}" EXACT IUPAC_NAME [IUPAC:] synonym: "C49H71N7O17" RELATED FORMULA [ChEBI:] synonym: "CCCCCCCCOc1ccc(cc1)C(=O)N[C@H]1C[C@@H](O)[C@@H](O)NC(=O)[C@@H]2[C@@H](O)[C@@H](C)CN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC1=O)[C@@H](C)O)[C@H](O)[C@@H](O)c1ccc(O)cc1)[C@@H](C)O" RELATED SMILES [ChEBI:] synonym: "cilofungin" RELATED INN [ChemIDplus:] synonym: "cilofungina" RELATED INN [ChemIDplus:] synonym: "cilofunginum" RELATED INN [ChemIDplus:] synonym: "InChI=1S/C49H71N7O17/c1-5-6-7-8-9-10-19-73-31-17-13-28(14-18-31)42(65)50-32-21-34(61)45(68)54-47(70)38-39(62)24(2)22-56(38)49(72)36(26(4)58)52-46(69)37(41(64)40(63)27-11-15-29(59)16-12-27)53-44(67)33-20-30(60)23-55(33)48(71)35(25(3)57)51-43(32)66/h11-18,24-26,30,32-41,45,57-64,68H,5-10,19-23H2,1-4H3,(H,50,65)(H,51,66)(H,52,69)(H,53,67)(H,54,70)/t24-,25+,26+,30+,32-,33-,34+,35-,36-,37-,38-,39-,40-,41-,45+/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=ZKZKCEAHVFVZDJ-MTUMARHDSA-N" RELATED InChIKey [ChEBI:] synonym: "N-{(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-23-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,12,15-tetrahydroxy-6,20-bis[(1R)-1-hydroxyethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl}-4-(octyloxy)benzamide" EXACT IUPAC_NAME [IUPAC:] xref: Beilstein:7164873 "Beilstein Registry Number" xref: ChemIDplus:79404-91-4 "CAS Registry Number" is_a: CHEBI:57248 ! echinocandin property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:31941 name: oxaliplatin namespace: chebi_ontology def: "A platinum coordination entity that has formula C6H14N2.C2O4.Pt." [] synonym: "(SP-4-2)[(1R,2R)-cyclohexane-1,2-diamine-kappa(2)N,N'][ethanedioato(2-)-kappa(2)O(1),O(2)]platinum" EXACT IUPAC_NAME [IUPAC:] synonym: "(SP-4-2-(1R-trans))-(1,2-cyclohexanediamine-N,N')(ethanedioato(2-)-O,O')platinum" RELATED [ChemIDplus:] synonym: "[H][N]1([H])[C@@H]2CCCC[C@H]2[N]([H])([H])[Pt]11OC(=O)C(=O)O1" RELATED SMILES [ChEBI:] synonym: "C6H14N2.C2O4.Pt" RELATED FORMULA [KEGG COMPOUND:] synonym: "C8H14N2O4Pt" RELATED FORMULA [ChEBI:] synonym: "Eloxatin" RELATED BRAND_NAME [KEGG DRUG:] synonym: "InChI=1S/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);/q;;+2/p-2/t5-,6-;;/m1../s1" RELATED InChI [ChEBI:] synonym: "InChIKey=ZROHGHOFXNOHSO-BNTLRKBRSA-L" RELATED InChIKey [ChEBI:] synonym: "oxalato(1,2-diaminocyclohexane)platinum(II)" RELATED [ChemIDplus:] synonym: "Oxaliplatin" EXACT [KEGG COMPOUND:] synonym: "oxaliplatin" RELATED INN [KEGG DRUG:] synonym: "oxaliplatine" RELATED INN [ChEBI:] synonym: "oxaliplatino" RELATED INN [DrugBank:] synonym: "oxaliplatinum" RELATED INN [DrugBank:] xref: ChemIDplus:63121-00-6 "CAS Registry Number" xref: DrugBank:DB00526 "DrugBank" xref: Gmelin:1046012 "Gmelin Registry Number" xref: Gmelin:28892 "Gmelin Registry Number" xref: KEGG COMPOUND:61825-94-3 "CAS Registry Number" xref: KEGG DRUG:D01790 "KEGG DRUG" is_a: CHEBI:33862 ! platinum coordination entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:32588 name: potassium chloride namespace: chebi_ontology def: "A metal chloride salt with a K(+) counterion." [] synonym: "[Cl-].[K+]" RELATED SMILES [ChEBI:] synonym: "[KCl]" RELATED [MolBase:] synonym: "ClK" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/ClH.K/h1H;/q;+1/p-1" RELATED InChI [ChEBI:] synonym: "InChIKey=WCUXLLCKKVVCTQ-UHFFFAOYSA-M" RELATED InChIKey [ChEBI:] synonym: "Kaliumchlorid" RELATED [ChEBI:] synonym: "Kaon-Cl 10" RELATED BRAND_NAME [KEGG DRUG:] synonym: "KCl" RELATED [IUPAC:] synonym: "Klor-con" RELATED BRAND_NAME [KEGG DRUG:] synonym: "Klotrix" RELATED BRAND_NAME [KEGG DRUG:] synonym: "Monopotassium chloride" RELATED [DrugBank:] synonym: "muriate of potash" RELATED [NIST Chemistry WebBook:] synonym: "potassium chloride" EXACT IUPAC_NAME [IUPAC:] synonym: "sylvite" RELATED [ChEBI:] xref: ChemIDplus:7447-40-7 "CAS Registry Number" xref: DrugBank:DB00761 "DrugBank" xref: KEGG DRUG:D02060 "KEGG DRUG" xref: MetaCyc:KCL "MetaCyc" xref: MolBase:881 "MolBase" xref: NIST Chemistry WebBook:7447-40-7 "CAS Registry Number" xref: Reaxys:3534978 "Reaxys Registry Number" xref: Wikipedia:Potassium_Chloride "Wikipedia" is_a: CHEBI:26218 ! potassium salt is_a: CHEBI:36093 ! inorganic chloride property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:3259 name: CCCP namespace: chebi_ontology def: "A hydrazone that has formula C9H5ClN4." [] synonym: "(3-chlorophenyl)hydrazonomalononitrile" RELATED [ChemIDplus:] synonym: "[(3-chlorophenyl)hydrazono]malononitrile" RELATED [ChemIDplus:] synonym: "[(3-chlorophenyl)hydrazono]propanedinitrile" RELATED [ChemIDplus:] synonym: "C9H5ClN4" RELATED FORMULA [KEGG COMPOUND:] synonym: "Carbonyl cyanide m-chlorophenyl hydrazone" RELATED [KEGG COMPOUND:] synonym: "carbonylcyanide-3-chlorophenylhydrazone" RELATED [ChemIDplus:] synonym: "CCCP" EXACT [KEGG COMPOUND:] synonym: "Clc1cccc(NN=C(C#N)C#N)c1" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C9H5ClN4/c10-7-2-1-3-8(4-7)13-14-9(5-11)6-12/h1-4,13H" RELATED InChI [ChEBI:] synonym: "InChIKey=UGTJLJZQQFGTJD-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "N'-(3-chlorophenyl)carbonohydrazonoyl dicyanide" EXACT IUPAC_NAME [IUPAC:] xref: ChemIDplus:1842102 "Beilstein Registry Number" xref: ChemIDplus:555-60-2 "CAS Registry Number" xref: KEGG COMPOUND:555-60-2 "CAS Registry Number" xref: KEGG COMPOUND:C11164 "KEGG COMPOUND" is_a: CHEBI:18379 ! nitrile is_a: CHEBI:38532 ! hydrazone is_a: CHEBI:83403 ! monochlorobenzenes property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:32876 name: tertiary amine namespace: chebi_ontology alt_id: CHEBI:26879 alt_id: CHEBI:9458 def: "A compound formally derived from ammonia by replacing three hydrogen atoms by hydrocarbyl groups." [] synonym: "[*]N([*])[*]" RELATED SMILES [ChEBI:] synonym: "NR3" RELATED FORMULA [ChEBI:] synonym: "R3N" RELATED [IUPAC:] synonym: "tertiaeres Amin" RELATED [ChEBI:] synonym: "Tertiary amine" EXACT [KEGG COMPOUND:] synonym: "tertiary amines" EXACT IUPAC_NAME [IUPAC:] xref: KEGG COMPOUND:C02196 "KEGG COMPOUND" is_a: CHEBI:32952 ! amine is_a: CHEBI:50996 ! tertiary amino compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:32877 name: primary amine namespace: chebi_ontology alt_id: CHEBI:26263 alt_id: CHEBI:26265 alt_id: CHEBI:8407 alt_id: CHEBI:8409 def: "A compound formally derived from ammonia by replacing one hydrogen atom by a hydrocarbyl group." [] synonym: "H2NR" RELATED FORMULA [ChEBI:] synonym: "N[*]" RELATED SMILES [ChEBI:] synonym: "primaeres Amin" RELATED [ChEBI:] synonym: "Primary amine" EXACT [KEGG COMPOUND:] synonym: "primary amines" EXACT IUPAC_NAME [IUPAC:] synonym: "Primary monoamine" RELATED [KEGG COMPOUND:] synonym: "R-NH2" RELATED [IUPAC:] synonym: "RCH2NH2" RELATED [KEGG COMPOUND:] xref: KEGG COMPOUND:C00375 "KEGG COMPOUND" xref: KEGG COMPOUND:C00893 "KEGG COMPOUND" xref: KEGG COMPOUND:C02580 "KEGG COMPOUND" is_a: CHEBI:32952 ! amine is_a: CHEBI:50994 ! primary amino compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:32952 name: amine namespace: chebi_ontology alt_id: CHEBI:13814 alt_id: CHEBI:22474 alt_id: CHEBI:2641 def: "A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "Amin" RELATED [ChEBI:] synonym: "Amine" EXACT [KEGG COMPOUND:] synonym: "amines" EXACT IUPAC_NAME [IUPAC:] synonym: "an amine" RELATED [UniProt:] synonym: "N[*]" RELATED SMILES [ChEBI:] synonym: "Substituted amine" RELATED [KEGG COMPOUND:] xref: KEGG COMPOUND:C00706 "KEGG COMPOUND" is_a: CHEBI:50047 ! organic amino compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:32955 name: epoxide namespace: chebi_ontology alt_id: CHEBI:13828 alt_id: CHEBI:23930 alt_id: CHEBI:4812 def: "Any cyclic ether in which the oxygen atom forms part of a 3-membered ring." [] synonym: "[*]C1([*])OC1([*])[*]" RELATED SMILES [ChEBI:] synonym: "Alkene oxide" RELATED [KEGG COMPOUND:] synonym: "an epoxide" RELATED [UniProt:] synonym: "C2H2OR2" RELATED FORMULA [KEGG COMPOUND:] synonym: "C2OR4" RELATED FORMULA [ChEBI:] synonym: "Epoxide" EXACT [KEGG COMPOUND:] synonym: "epoxides" EXACT IUPAC_NAME [IUPAC:] synonym: "epoxides" RELATED [ChEBI:] synonym: "Olefin oxide" RELATED [KEGG COMPOUND:] xref: CiteXplore:10891060 "PubMed citation" xref: KEGG COMPOUND:C00722 "KEGG COMPOUND" xref: Wikipedia:Epoxide "Wikipedia" is_a: CHEBI:37407 ! cyclic ether property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:32988 name: amide namespace: chebi_ontology alt_id: CHEBI:22473 alt_id: CHEBI:2633 def: "An amide is a derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "Amide" EXACT [KEGG COMPOUND:] synonym: "amides" EXACT IUPAC_NAME [IUPAC:] synonym: "NC([*])=O" RELATED SMILES [ChEBI:] xref: KEGG COMPOUND:C00241 "KEGG COMPOUND" is_a: CHEBI:51143 ! nitrogen molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33238 name: monoatomic entity namespace: chebi_ontology def: "A monoatomic entity is a molecular entity consisting of a single atom." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "atomic entity" RELATED [ChEBI:] synonym: "monoatomic entities" RELATED [ChEBI:] is_a: CHEBI:33259 ! elemental molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33240 name: coordination entity namespace: chebi_ontology def: "An assembly consisting of a central atom (usually metallic) to which is attached a surrounding array of other groups of atoms (ligands)." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "coordination compounds" RELATED [ChEBI:] synonym: "coordination entities" EXACT IUPAC_NAME [IUPAC:] synonym: "coordination entity" EXACT IUPAC_NAME [IUPAC:] is_a: CHEBI:37577 ! heteroatomic molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33241 name: oxoacid derivative namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "oxoacid derivatives" RELATED [ChEBI:] is_a: CHEBI:37577 ! heteroatomic molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33242 name: inorganic hydride namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "inorganic hydrides" RELATED [ChEBI:] is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:33692 ! hydrides property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33245 name: organic fundamental parent namespace: chebi_ontology def: "An organic fundamental parent is a structure used as a basis for substitutive names in organic nomenclature, containing, in addition to one or more hydrogen atoms, a single atom of an element, a number of atoms (alike or different) linked together to form an unbranched chain, a monocyclic or polycyclic ring system, or a ring assembly or ring/chain system." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "organic fundamental parents" RELATED [ChEBI:] synonym: "organic parent hydrides" RELATED [ChEBI:] is_a: CHEBI:37175 ! organic hydride is_a: CHEBI:50860 ! organic molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33247 name: organic group namespace: chebi_ontology def: "Any substituent group or skeleton containing carbon." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "organic groups" RELATED [ChEBI:] is_a: CHEBI:24433 ! group property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33256 name: primary amide namespace: chebi_ontology def: "A derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "primary amide" EXACT [IUPAC:] synonym: "primary amides" EXACT IUPAC_NAME [IUPAC:] is_a: CHEBI:32988 ! amide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33257 name: secondary amide namespace: chebi_ontology def: "A derivative of two oxoacids RkE(=O)l(OH)m (l =/= 0) in which two acyl groups are attached to the amino or substituted amino group." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "secondary amide" EXACT IUPAC_NAME [IUPAC:] synonym: "secondary amides" EXACT IUPAC_NAME [IUPAC:] is_a: CHEBI:32988 ! amide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33259 name: elemental molecular entity namespace: chebi_ontology def: "A molecular entity all atoms of which have the same atomic number." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "homoatomic entity" RELATED [ChEBI:] synonym: "homoatomic molecular entities" RELATED [ChEBI:] synonym: "homoatomic molecular entity" RELATED [ChEBI:] is_a: CHEBI:23367 ! molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33261 name: organosulfur compound namespace: chebi_ontology alt_id: CHEBI:23010 alt_id: CHEBI:25714 def: "An organosulfur compound is a compound containing at least one carbon-sulfur bond." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "organosulfur compound" EXACT [ChEBI:] synonym: "organosulfur compounds" RELATED [ChEBI:] xref: Wikipedia:Organosulfur_compounds "Wikipedia" is_a: CHEBI:26835 ! sulfur molecular entity is_a: CHEBI:36962 ! organochalcogen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33262 name: elemental oxygen namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:25806 ! oxygen molecular entity is_a: CHEBI:33259 ! elemental molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33273 name: polyatomic anion namespace: chebi_ontology def: "An anion consisting of more than one atom." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "polyatomic anions" RELATED [ChEBI:] is_a: CHEBI:22563 ! anion is_a: CHEBI:36358 ! polyatomic ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33285 name: heteroorganic entity namespace: chebi_ontology def: "A heteroorganic entity is an organic molecular entity in which carbon atoms or organic groups are bonded directly to one or more heteroatoms." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "heteroorganic entities" RELATED [ChEBI:] synonym: "organoelement compounds" RELATED [ChEBI:] is_a: CHEBI:50860 ! organic molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33296 name: alkali metal molecular entity namespace: chebi_ontology def: "A molecular entity containing one or more atoms of an alkali metal." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "alkali metal molecular entities" RELATED [ChEBI:] is_a: CHEBI:33674 ! s-block molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33299 name: alkaline earth molecular entity namespace: chebi_ontology def: "An alkaline earth molecular entity is a molecular entity containing one or more atoms of an alkaline earth metal." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "alkaline earth compounds" RELATED [ChEBI:] synonym: "alkaline earth molecular entities" RELATED [ChEBI:] synonym: "alkaline earth molecular entity" EXACT [ChEBI:] synonym: "alkaline-earth compounds" RELATED [ChEBI:] is_a: CHEBI:33674 ! s-block molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33302 name: pnictogen molecular entity namespace: chebi_ontology def: "A p-block molecular entity containing any pnictogen." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "pnictogen molecular entities" RELATED [ChEBI:] synonym: "pnictogen molecular entity" EXACT [ChEBI:] is_a: CHEBI:33675 ! p-block molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33304 name: chalcogen molecular entity namespace: chebi_ontology def: "Any p-block molecular entity containing a chalcogen." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "chalcogen compounds" RELATED [ChEBI:] synonym: "chalcogen molecular entities" RELATED [ChEBI:] synonym: "chalcogen molecular entity" EXACT [ChEBI:] is_a: CHEBI:33675 ! p-block molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33308 name: carboxylic ester namespace: chebi_ontology alt_id: CHEBI:13204 alt_id: CHEBI:23028 alt_id: CHEBI:3408 def: "An ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl." [] synonym: "[*]C(=O)O[*]" RELATED SMILES [ChEBI:] synonym: "a carboxylic ester" RELATED [UniProt:] synonym: "carboxylic acid esters" RELATED [ChEBI:] synonym: "Carboxylic ester" EXACT [KEGG COMPOUND:] synonym: "carboxylic esters" EXACT IUPAC_NAME [IUPAC:] synonym: "CO2R2" RELATED FORMULA [ChEBI:] xref: KEGG COMPOUND:C02391 "KEGG COMPOUND" xref: Wikipedia:Ester "Wikipedia" is_a: CHEBI:35701 ! ester is_a: CHEBI:36586 ! carbonyl compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33327 name: silicon oxide namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "oxides of silicon" RELATED [ChEBI:] synonym: "silicon oxides" RELATED [ChEBI:] is_a: CHEBI:24836 ! inorganic oxide is_a: CHEBI:26677 ! silicon molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33424 name: sulfur oxoacid derivative namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "sulfur oxoacid derivative" EXACT [ChEBI:] synonym: "sulfur oxoacid derivatives" RELATED [ChEBI:] is_a: CHEBI:26835 ! sulfur molecular entity is_a: CHEBI:33241 ! oxoacid derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33437 name: chlorine oxoanion namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "chlorine oxoanion" EXACT [ChEBI:] synonym: "chlorine oxoanions" RELATED [ChEBI:] is_a: CHEBI:23117 ! chlorine molecular entity is_a: CHEBI:33443 ! halogen oxoanion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33443 name: halogen oxoanion namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "halogen oxoanion" EXACT [ChEBI:] synonym: "halogen oxoanions" RELATED [ChEBI:] is_a: CHEBI:24471 ! halogen molecular entity is_a: CHEBI:24834 ! inorganic anion is_a: CHEBI:35406 ! oxoanion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33447 name: phospho sugar namespace: chebi_ontology alt_id: CHEBI:15132 alt_id: CHEBI:25406 alt_id: CHEBI:26086 alt_id: CHEBI:9320 def: "Any monosaccharide containing an alcoholic hydroxy group esterified with phosphoric acid." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "monosaccharide phosphates" RELATED [ChEBI:] synonym: "phospho sugar" EXACT [ChEBI:] synonym: "phospho sugars" RELATED [ChEBI:] synonym: "phosphorylated sugar" RELATED [ChEBI:] synonym: "phosphorylated sugars" RELATED [ChEBI:] synonym: "phosphosugar" RELATED [ChEBI:] synonym: "phosphosugars" RELATED [ChEBI:] synonym: "Sugar phosphate" RELATED [KEGG COMPOUND:] synonym: "sugar phosphate" RELATED [UniProt:] xref: CiteXplore:18186488 "PubMed citation" xref: KEGG COMPOUND:C00934 "KEGG COMPOUND" is_a: CHEBI:26816 ! carbohydrate phosphate is_a: CHEBI:63367 ! monosaccharide derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33458 name: nitrogen oxoanion namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "nitrogen oxoanion" EXACT [ChEBI:] synonym: "nitrogen oxoanions" RELATED [ChEBI:] synonym: "oxoanions of nitrogen" RELATED [ChEBI:] is_a: CHEBI:33459 ! pnictogen oxoanion is_a: CHEBI:51143 ! nitrogen molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33459 name: pnictogen oxoanion namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "pnictogen oxoanion" EXACT [ChEBI:] synonym: "pnictogen oxoanions" RELATED [ChEBI:] is_a: CHEBI:33302 ! pnictogen molecular entity is_a: CHEBI:35406 ! oxoanion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33482 name: sulfur oxoanion namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "oxoanions of sulfur" RELATED [ChEBI:] synonym: "sulfur oxoanion" EXACT [ChEBI:] synonym: "sulfur oxoanions" RELATED [ChEBI:] is_a: CHEBI:26835 ! sulfur molecular entity is_a: CHEBI:33485 ! chalcogen oxoanion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33485 name: chalcogen oxoanion namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "chalcogen oxoanion" EXACT [ChEBI:] synonym: "chalcogen oxoanions" RELATED [ChEBI:] is_a: CHEBI:35406 ! oxoanion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33488 name: selenium oxoanion namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "oxoanions of selenium" RELATED [ChEBI:] synonym: "selenium oxoanion" EXACT [ChEBI:] synonym: "selenium oxoanions" RELATED [ChEBI:] is_a: CHEBI:26628 ! selenium molecular entity is_a: CHEBI:33485 ! chalcogen oxoanion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33497 name: transition element molecular entity namespace: chebi_ontology def: "A molecular entity containing one or more atoms of a transition element." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "transition element molecular entities" RELATED [ChEBI:] synonym: "transition metal molecular entity" RELATED [ChEBI:] is_a: CHEBI:23367 ! molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33504 name: alkali metal cation namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "alkali metal cations" RELATED [ChEBI:] is_a: CHEBI:25213 ! metal cation property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33513 name: alkaline earth cation namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "alkaline earth cations" RELATED [ChEBI:] synonym: "alkaline earth metal cation" RELATED [ChEBI:] synonym: "alkaline-earth metal cations" RELATED [ChEBI:] is_a: CHEBI:25213 ! metal cation is_a: CHEBI:33299 ! alkaline earth molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33515 name: transition element cation namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "transition element cations" RELATED [ChEBI:] synonym: "transition metal cation" RELATED [ChEBI:] is_a: CHEBI:25213 ! metal cation property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33552 name: sulfonic acid derivative namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "derivatives of sulfonic acid" RELATED [ChEBI:] synonym: "sulfonic acid derivative" EXACT [ChEBI:] synonym: "sulfonic acid derivatives" RELATED [ChEBI:] is_a: CHEBI:33424 ! sulfur oxoacid derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33554 name: organosulfonate oxoanion namespace: chebi_ontology def: "An organic anion obtained by deprotonation of the sufonate group(s) of any organosulfonic acid." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "[O-]S([*])(=O)=O" RELATED SMILES [ChEBI:] synonym: "O3SR" RELATED FORMULA [ChEBI:] synonym: "organosulfonate" RELATED [ChEBI:] synonym: "organosulfonate oxoanions" RELATED [ChEBI:] synonym: "organosulfonates" RELATED [ChEBI:] is_a: CHEBI:25696 ! organic anion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33558 name: alpha-amino-acid anion namespace: chebi_ontology def: "An amino-acid anion that is the conjugate base of an alpha-amino acid." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "alpha-amino acid anions" RELATED [ChEBI:] synonym: "alpha-amino-acid anion" EXACT [ChEBI:] synonym: "alpha-amino-acid anions" RELATED [ChEBI:] is_a: CHEBI:37022 ! amino-acid anion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33563 name: glycolipid namespace: chebi_ontology alt_id: CHEBI:24393 alt_id: CHEBI:5476 def: "Any member of class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). Some substances classified as bacterial glycolipids have the sugar part acylated by one or more fatty acids and the glycerol part may be absent." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "Glycolipid" EXACT [KEGG COMPOUND:] synonym: "glycolipids" EXACT IUPAC_NAME [IUPAC:] xref: KEGG COMPOUND:C05005 "KEGG COMPOUND" xref: Wikipedia:Glycolipids "Wikipedia" is_a: CHEBI:35740 ! liposaccharide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33566 name: catechols namespace: chebi_ontology alt_id: CHEBI:13628 alt_id: CHEBI:18862 def: "Any compound containing an o-diphenol component." [] synonym: "1,2-benzenediols" RELATED [ChEBI:] synonym: "a catechol" RELATED [UniProt:] xref: KEGG COMPOUND:C15571 "KEGG COMPOUND" is_a: CHEBI:33570 ! benzenediols property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33570 name: benzenediols namespace: chebi_ontology alt_id: CHEBI:22705 alt_id: CHEBI:22711 synonym: "." RELATED FORMULA [ChEBI:] is_a: CHEBI:33853 ! phenols property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33572 name: resorcinols namespace: chebi_ontology def: "Any benzenediol in which the two hydroxy groups are meta to one another." [] synonym: "." RELATED FORMULA [ChEBI:] is_a: CHEBI:33570 ! benzenediols property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33575 name: carboxylic acid namespace: chebi_ontology alt_id: CHEBI:13428 alt_id: CHEBI:13627 alt_id: CHEBI:23027 def: "A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid." [] synonym: "acide carboxylique" RELATED [IUPAC:] synonym: "acides carboxyliques" RELATED [IUPAC:] synonym: "acido carboxilico" RELATED [IUPAC:] synonym: "acidos carboxilicos" RELATED [IUPAC:] synonym: "Carbonsaeure" RELATED [ChEBI:] synonym: "Carbonsaeuren" RELATED [ChEBI:] synonym: "carboxylic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "carboxylic acids" EXACT IUPAC_NAME [IUPAC:] synonym: "CHO2R" RELATED FORMULA [ChEBI:] synonym: "Karbonsaeure" RELATED [ChEBI:] synonym: "OC([*])=O" RELATED SMILES [ChEBI:] synonym: "RC(=O)OH" RELATED [IUPAC:] xref: CiteXplore:17147560 "PubMed citation" xref: CiteXplore:18433345 "PubMed citation" is_a: CHEBI:35605 ! carbon oxoacid is_a: CHEBI:36586 ! carbonyl compound is_a: CHEBI:64709 ! organic acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33576 name: sulfur-containing carboxylic acid namespace: chebi_ontology def: "Any carboxylic acid having a sulfur substituent." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "S-containing carboxylic acid" RELATED [ChEBI:] synonym: "S-containing carboxylic acids" RELATED [ChEBI:] synonym: "sulfur-containing carboxylic acids" RELATED [ChEBI:] is_a: CHEBI:33261 ! organosulfur compound is_a: CHEBI:33575 ! carboxylic acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33579 name: main group molecular entity namespace: chebi_ontology def: "A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, and 18 of the periodic table." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "main group compounds" RELATED [ChEBI:] synonym: "main group molecular entities" RELATED [ChEBI:] is_a: CHEBI:23367 ! molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33581 name: boron group molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "boron group molecular entities" RELATED [ChEBI:] is_a: CHEBI:33675 ! p-block molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33582 name: carbon group molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "carbon group molecular entities" RELATED [ChEBI:] synonym: "carbon group molecular entity" EXACT [ChEBI:] is_a: CHEBI:33675 ! p-block molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33585 name: lead molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "lead compounds" RELATED [ChEBI:] synonym: "lead molecular entities" RELATED [ChEBI:] synonym: "lead molecular entity" EXACT [ChEBI:] is_a: CHEBI:33582 ! carbon group molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33595 name: cyclic compound namespace: chebi_ontology def: "Any molecule that consists of a series of atoms joined together to form a ring." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "cyclic compounds" RELATED [ChEBI:] xref: Wikipedia:Cyclic_compound "Wikipedia" is_a: CHEBI:25367 ! molecule property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33597 name: homocyclic compound namespace: chebi_ontology def: "A cyclic compound having as ring members atoms of the same element only." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "homocyclic compound" EXACT IUPAC_NAME [IUPAC:] synonym: "homocyclic compounds" EXACT IUPAC_NAME [IUPAC:] synonym: "isocyclic compounds" RELATED [IUPAC:] is_a: CHEBI:33595 ! cyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33598 name: carbocyclic compound namespace: chebi_ontology def: "A cyclic compound in which all of the ring members are carbon atoms." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "carbocycle" RELATED [ChEBI:] synonym: "carbocyclic compound" EXACT IUPAC_NAME [IUPAC:] synonym: "carbocyclic compounds" EXACT IUPAC_NAME [IUPAC:] is_a: CHEBI:33597 ! homocyclic compound is_a: CHEBI:33832 ! organic cyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33599 name: spiro compound namespace: chebi_ontology def: "A compound having one atom as the only common member of two rings." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "spiro compound" EXACT IUPAC_NAME [IUPAC:] synonym: "spiro compounds" EXACT IUPAC_NAME [IUPAC:] synonym: "spiro-fused compounds" RELATED [IUPAC:] synonym: "spirocycle" RELATED [ChEBI:] synonym: "spirocycles" RELATED [ChEBI:] synonym: "spirocyclic compound" RELATED [ChEBI:] synonym: "spirocyclic compounds" RELATED [ChEBI:] synonym: "spirofused compounds" RELATED [ChEBI:] is_a: CHEBI:33635 ! polycyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33608 name: hydrogen molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "hydrogen compounds" RELATED [ChEBI:] synonym: "hydrogen molecular entities" RELATED [ChEBI:] is_a: CHEBI:33674 ! s-block molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33620 name: aluminium molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "aluminium compounds" RELATED [ChEBI:] synonym: "aluminium molecular entities" RELATED [ChEBI:] synonym: "aluminium molecular entity" EXACT [ChEBI:] synonym: "aluminum compounds" RELATED [ChEBI:] is_a: CHEBI:33581 ! boron group molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33628 name: elemental aluminium namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "elemental aluminum" RELATED [ChEBI:] is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:33259 ! elemental molecular entity is_a: CHEBI:33620 ! aluminium molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33635 name: polycyclic compound namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "polycyclic compounds" RELATED [ChEBI:] is_a: CHEBI:33595 ! cyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33636 name: bicyclic compound namespace: chebi_ontology def: "A molecule that features two fused rings." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "bicyclic compounds" RELATED [ChEBI:] is_a: CHEBI:33595 ! cyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33655 name: aromatic compound namespace: chebi_ontology def: "A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekule structure) is said to possess aromatic character." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "aromatic compounds" EXACT IUPAC_NAME [IUPAC:] synonym: "aromatic molecular entity" EXACT IUPAC_NAME [IUPAC:] synonym: "aromatics" RELATED [ChEBI:] synonym: "aromatische Verbindungen" RELATED [ChEBI:] is_a: CHEBI:33595 ! cyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33659 name: organic aromatic compound namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "organic aromatic compounds" RELATED [ChEBI:] is_a: CHEBI:33655 ! aromatic compound is_a: CHEBI:33832 ! organic cyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33661 name: monocyclic compound namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "monocyclic compounds" RELATED [ChEBI:] is_a: CHEBI:33595 ! cyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33670 name: heteromonocyclic compound namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "heteromonocyclic compound" EXACT IUPAC_NAME [IUPAC:] synonym: "heteromonocyclic compounds" EXACT IUPAC_NAME [IUPAC:] is_a: CHEBI:33661 ! monocyclic compound is_a: CHEBI:5686 ! heterocyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33671 name: heteropolycyclic compound namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "heteropolycyclic compounds" EXACT IUPAC_NAME [IUPAC:] synonym: "polyheterocyclic compounds" RELATED [ChEBI:] is_a: CHEBI:33635 ! polycyclic compound is_a: CHEBI:5686 ! heterocyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33672 name: heterobicyclic compound namespace: chebi_ontology def: "A bicyclic compound in which at least one of the rings contains at least one skeletal heteroatom." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "heterobicyclic compounds" EXACT IUPAC_NAME [IUPAC:] is_a: CHEBI:33636 ! bicyclic compound is_a: CHEBI:5686 ! heterocyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33673 name: zinc group molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "zinc group molecular entities" RELATED [ChEBI:] is_a: CHEBI:33676 ! d-block molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33674 name: s-block molecular entity namespace: chebi_ontology def: "An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "s-block compounds" RELATED [ChEBI:] synonym: "s-block molecular entities" RELATED [ChEBI:] synonym: "s-block molecular entity" EXACT [ChEBI:] is_a: CHEBI:33579 ! main group molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33675 name: p-block molecular entity namespace: chebi_ontology def: "A p-block molecular entity is a molecular entity containing one or more atoms of a p-block element." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "p-block compounds" RELATED [ChEBI:] synonym: "p-block molecular entities" RELATED [ChEBI:] synonym: "p-block molecular entitiy" RELATED [ChEBI:] is_a: CHEBI:33579 ! main group molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33676 name: d-block molecular entity namespace: chebi_ontology def: "A d-block molecular entity is a molecular entity containing one or more atoms of a d-block element." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "d-block compounds" RELATED [ChEBI:] synonym: "d-block molecular entities" RELATED [ChEBI:] synonym: "d-block molecular entity" EXACT [ChEBI:] is_a: CHEBI:33497 ! transition element molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33692 name: hydrides namespace: chebi_ontology def: "Hydrides are chemical compounds of hydrogen with other chemical elements." [] synonym: "." RELATED FORMULA [ChEBI:] is_a: CHEBI:33608 ! hydrogen molecular entity is_a: CHEBI:37577 ! heteroatomic molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33694 name: biomacromolecule namespace: chebi_ontology def: "A macromolecule formed by a living organism." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "biomacromolecules" RELATED [ChEBI:] synonym: "biopolymer" EXACT IUPAC_NAME [IUPAC:] synonym: "Biopolymere" RELATED [ChEBI:] synonym: "biopolymers" RELATED [ChEBI:] is_a: CHEBI:33839 ! macromolecule is_a: CHEBI:50860 ! organic molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33695 name: information biomacromolecule namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "genetically encoded biomacromolecules" RELATED [ChEBI:] synonym: "genetically encoded biopolymers" RELATED [ChEBI:] synonym: "information biomacromolecules" RELATED [ChEBI:] synonym: "information biopolymers" RELATED [ChEBI:] synonym: "information macromolecule" RELATED [ChEBI:] synonym: "information macromolecules" RELATED [ChEBI:] is_a: CHEBI:33694 ! biomacromolecule property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33696 name: nucleic acid namespace: chebi_ontology def: "A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "acide nucleique" RELATED [ChEBI:] synonym: "acides nucleiques" RELATED [ChEBI:] synonym: "acido nucleico" RELATED [ChEBI:] synonym: "acidos nucleicos" RELATED [ChEBI:] synonym: "NA" RELATED [ChEBI:] synonym: "nucleic acids" EXACT IUPAC_NAME [IUPAC:] synonym: "Nukleinsaeure" RELATED [ChEBI:] synonym: "Nukleinsaeuren" RELATED [ChEBI:] is_a: CHEBI:15986 ! polynucleotide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33697 name: ribonucleic acid namespace: chebi_ontology def: "High molecular weight, linear polymers, composed of nucleotides containing ribose and linked by phosphodiester bonds; RNA is central to the synthesis of proteins." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "pentosenucleic acids" RELATED [ChemIDplus:] synonym: "ribonucleic acid" EXACT [IUPAC:] synonym: "ribonucleic acids" EXACT IUPAC_NAME [IUPAC:] synonym: "ribonucleic acids" RELATED [ChEBI:] synonym: "Ribonukleinsaeure" RELATED [ChEBI:] synonym: "ribose nucleic acid" RELATED [ChEBI:] synonym: "RNA" RELATED [IUPAC:] synonym: "RNS" RELATED [ChEBI:] synonym: "yeast nucleic acid" RELATED [ChEBI:] xref: ChemIDplus:63231-63-0 "CAS Registry Number" is_a: CHEBI:33696 ! nucleic acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33702 name: polyatomic cation namespace: chebi_ontology def: "A cation consisting of more than one atom." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "polyatomic cations" RELATED [ChEBI:] is_a: CHEBI:36358 ! polyatomic ion is_a: CHEBI:36916 ! cation property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33704 name: alpha-amino acid namespace: chebi_ontology alt_id: CHEBI:10208 alt_id: CHEBI:13779 alt_id: CHEBI:22442 alt_id: CHEBI:2642 def: "An amino acid in which the amino group is located on the carbon atom at the position alpha to the carboxy group." [] synonym: "alpha-Amino acid" EXACT [KEGG COMPOUND:] synonym: "alpha-amino acid" EXACT IUPAC_NAME [IUPAC:] synonym: "alpha-amino acids" RELATED [ChEBI:] synonym: "alpha-amino acids" RELATED [JCBN:] synonym: "alpha-amino carboxylic acids" RELATED [IUPAC:] synonym: "Amino acid" RELATED [KEGG COMPOUND:] synonym: "Amino acids" RELATED [KEGG COMPOUND:] synonym: "C2H4NO2R" RELATED FORMULA [ChEBI:] synonym: "C2H4NO2R" RELATED FORMULA [KEGG COMPOUND:] synonym: "NC([*])C(O)=O" RELATED SMILES [ChEBI:] xref: KEGG COMPOUND:C00045 "KEGG COMPOUND" xref: KEGG COMPOUND:C05167 "KEGG COMPOUND" is_a: CHEBI:33709 ! amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33708 name: amino-acid residue namespace: chebi_ontology def: "When two or more amino acids combine to form a peptide, the elements of water are removed, and what remains of each amino acid is called an amino-acid residue." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "amino acid residue" RELATED [ChEBI:] synonym: "amino-acid residue" EXACT IUPAC_NAME [IUPAC:] synonym: "amino-acid residues" RELATED [JCBN:] is_a: CHEBI:33247 ! organic group property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33709 name: amino acid namespace: chebi_ontology alt_id: CHEBI:13815 alt_id: CHEBI:22477 def: "A carboxylic acid containing one or more amino groups." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "amino acids" RELATED [ChEBI:] synonym: "Aminocarbonsaeure" RELATED [ChEBI:] synonym: "Aminokarbonsaeure" RELATED [ChEBI:] synonym: "Aminosaeure" RELATED [ChEBI:] xref: Wikipedia:Amino_acid "Wikipedia" is_a: CHEBI:33575 ! carboxylic acid is_a: CHEBI:50047 ! organic amino compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33710 name: alpha-amino-acid residue namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "alpha-amino-acid residues" RELATED [ChEBI:] is_a: CHEBI:33708 ! amino-acid residue property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33721 name: carbohydrate acid anion namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "carbohydrate acid anion" EXACT [ChEBI:] synonym: "carbohydrate acid anions" RELATED [ChEBI:] is_a: CHEBI:29067 ! carboxylic acid anion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33741 name: chromium group molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "chromium group molecular entities" RELATED [ChEBI:] synonym: "chromium group molecular entity" EXACT [ChEBI:] is_a: CHEBI:33676 ! d-block molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33743 name: manganese group molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "manganese group molecular entities" RELATED [ChEBI:] synonym: "manganese group molecular entity" EXACT [ChEBI:] is_a: CHEBI:33676 ! d-block molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33744 name: iron group molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "iron group molecular entities" RELATED [ChEBI:] synonym: "iron group molecular entity" EXACT [ChEBI:] is_a: CHEBI:33676 ! d-block molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33745 name: copper group molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "copper group molecular entities" RELATED [ChEBI:] synonym: "copper group molecular entity" EXACT [ChEBI:] is_a: CHEBI:33676 ! d-block molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33746 name: vanadium group molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "vanadium group molecular entities" RELATED [ChEBI:] synonym: "vanadium group molecular entity" EXACT [ChEBI:] is_a: CHEBI:33676 ! d-block molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33747 name: nickel group molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "nickel group molecular entities" RELATED [ChEBI:] synonym: "nickel group molecular entity" EXACT [ChEBI:] is_a: CHEBI:33676 ! d-block molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33749 name: platinum molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "platinum compounds" RELATED [ChEBI:] synonym: "platinum molecular entities" RELATED [ChEBI:] synonym: "platinum molecular entity" EXACT [ChEBI:] is_a: CHEBI:33747 ! nickel group molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33760 name: hexonate namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "aldohexonates" RELATED [ChEBI:] synonym: "hexonate" EXACT [ChEBI:] synonym: "hexonates" RELATED [ChEBI:] is_a: CHEBI:22299 ! aldonate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33804 name: gluconates namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] is_a: CHEBI:33760 ! hexonate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33822 name: organic hydroxy compound namespace: chebi_ontology alt_id: CHEBI:64710 def: "An organic compound having at least one hydroxy group attached to a carbon atom." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "hydroxy compounds" EXACT IUPAC_NAME [IUPAC:] synonym: "organic alcohol" RELATED [ChEBI:] synonym: "organic hydroxy compounds" RELATED [ChEBI:] is_a: CHEBI:24651 ! hydroxides is_a: CHEBI:50860 ! organic molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33832 name: organic cyclic compound namespace: chebi_ontology def: "Any organic molecule that consists of atoms connected in the form of a ring." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "organic cyclic compounds" RELATED [ChEBI:] is_a: CHEBI:33595 ! cyclic compound is_a: CHEBI:72695 ! organic molecule property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33833 name: heteroarene namespace: chebi_ontology def: "A heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2)." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "hetarenes" RELATED [IUPAC:] synonym: "heteroarenes" EXACT IUPAC_NAME [IUPAC:] is_a: CHEBI:24532 ! organic heterocyclic compound is_a: CHEBI:33659 ! organic aromatic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33836 name: benzenoid aromatic compound namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "benzenoid aromatic compounds" RELATED [ChEBI:] synonym: "benzenoid compound" RELATED [ChEBI:] is_a: CHEBI:33598 ! carbocyclic compound is_a: CHEBI:33659 ! organic aromatic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33838 name: nucleoside namespace: chebi_ontology alt_id: CHEBI:13661 alt_id: CHEBI:25611 alt_id: CHEBI:7647 def: "An N-glycosyl compound that has both a nucleobase, normally adenine, guanine, xanthine, thymine, cytosine or uracil, and either a ribose or deoxyribose as functional parents." [] synonym: "a nucleoside" RELATED [UniProt:] synonym: "C5H9O4R" RELATED FORMULA [KEGG COMPOUND:] synonym: "Nucleoside" EXACT [KEGG COMPOUND:] synonym: "nucleosides" EXACT IUPAC_NAME [IUPAC:] synonym: "nucleosides" RELATED [ChEBI:] synonym: "OC[C@H]1O[C@@H]([*])[C@H](O)[C@@H]1O" RELATED SMILES [ChEBI:] xref: KEGG COMPOUND:C00801 "KEGG COMPOUND" is_a: CHEBI:21731 ! N-glycosyl compound is_a: CHEBI:26912 ! oxolanes is_a: CHEBI:61120 ! nucleobase-containing molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33839 name: macromolecule namespace: chebi_ontology def: "A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "macromolecule" EXACT IUPAC_NAME [IUPAC:] synonym: "macromolecules" RELATED [ChEBI:] synonym: "polymer" RELATED [ChEBI:] synonym: "polymer molecule" RELATED [IUPAC:] synonym: "polymers" RELATED [ChEBI:] xref: Wikipedia:Macromolecule "Wikipedia" is_a: CHEBI:36357 ! polyatomic entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:338412 name: (-)-anisomycin namespace: chebi_ontology alt_id: CHEBI:2737 alt_id: CHEBI:40748 def: "An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system." [] synonym: "(2R,3S,4S)-4-hydroxy-2-(4-methoxybenzyl)pyrrolidin-3-yl acetate" EXACT IUPAC_NAME [IUPAC:] synonym: "(2R,3S,4S)-4-hydroxy-2-(4-methoxybenzyl)pyrrolidin-3-yl acetate" RELATED [PDBeChem:] synonym: "1,4,5-Trideoxy-1,4-imino-5-(p-methoxyphenyl)-D-xylo-pentitol 3-acetate" RELATED [ChemIDplus:] synonym: "2-(p-Methoxybenzyl)-3,4-pyrrolidinediol 3-acetate" RELATED [ChemIDplus:] synonym: "2-p-Methoxyphenylmethyl-3-acetoxy-4-hydroxypyrrolidine" RELATED [ChemIDplus:] synonym: "ANISOMYCIN" RELATED [PDBeChem:] synonym: "Anisomycin" RELATED [KEGG COMPOUND:] synonym: "C14H19NO4" RELATED FORMULA [ChEBI:] synonym: "COc1ccc(C[C@H]2NC[C@H](O)[C@H]2OC(C)=O)cc1" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=YKJYKKNCCRKFSL-RDBSUJKOSA-N" RELATED InChIKey [ChEBI:] xref: Beilstein:20705 "Beilstein Registry Number" xref: ChEMBL:16005213 "PubMed citation" xref: ChEMBL:6834379 "PubMed citation" xref: ChemIDplus:22862-76-6 "CAS Registry Number" xref: CiteXplore:22004851 "PubMed citation" xref: CiteXplore:23192275 "PubMed citation" xref: CiteXplore:23525555 "PubMed citation" xref: CiteXplore:23582782 "PubMed citation" xref: CiteXplore:24333448 "PubMed citation" xref: DrugBank:DB07374 "DrugBank" xref: KEGG COMPOUND:22862-76-6 "CAS Registry Number" xref: KEGG COMPOUND:C11281 "KEGG COMPOUND" xref: PDBeChem:ANM "PDBeChem" xref: Reaxys:20705 "Reaxys Registry Number" xref: Wikipedia:Anisomycin "Wikipedia" is_a: CHEBI:25558 ! organonitrogen heterocyclic antibiotic is_a: CHEBI:46777 ! monohydroxypyrrolidine property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33853 name: phenols namespace: chebi_ontology alt_id: CHEBI:13664 alt_id: CHEBI:13825 alt_id: CHEBI:25969 alt_id: CHEBI:2857 def: "Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "arenols" RELATED [IUPAC:] synonym: "Aryl alcohol" RELATED [KEGG COMPOUND:] synonym: "aryl alcohol" RELATED [UniProt:] synonym: "phenols" EXACT IUPAC_NAME [IUPAC:] xref: KEGG COMPOUND:C15584 "KEGG COMPOUND" xref: MetaCyc:Aryl-Alcohol "MetaCyc" xref: Wikipedia:Phenols "Wikipedia" is_a: CHEBI:33659 ! organic aromatic compound is_a: CHEBI:33822 ! organic hydroxy compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33856 name: aromatic amino acid namespace: chebi_ontology alt_id: CHEBI:13820 alt_id: CHEBI:22623 alt_id: CHEBI:2835 synonym: "Aromatic amino acid" EXACT [KEGG COMPOUND:] synonym: "aromatic amino acid" EXACT [UniProt:] synonym: "aromatic amino acids" RELATED [ChEBI:] synonym: "Aromatic L-amino acid" RELATED [KEGG COMPOUND:] synonym: "C2H4NO2R" RELATED FORMULA [KEGG COMPOUND:] synonym: "N[C@@H](C[*])C(O)=O" RELATED SMILES [ChEBI:] xref: KEGG COMPOUND:C01021 "KEGG COMPOUND" is_a: CHEBI:33659 ! organic aromatic compound is_a: CHEBI:33709 ! amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33860 name: aromatic amine namespace: chebi_ontology alt_id: CHEBI:13827 alt_id: CHEBI:22622 alt_id: CHEBI:22646 alt_id: CHEBI:2834 alt_id: CHEBI:2863 def: "An amino compound in which the amino group is linked directly to an aromatic system." [] synonym: "aromatic amines" RELATED [ChEBI:] synonym: "aryl amine" RELATED [ChEBI:] synonym: "aryl amines" RELATED [ChEBI:] synonym: "arylamine" RELATED [ChEBI:] synonym: "arylamines" RELATED [ChEBI:] synonym: "C6H7N" RELATED FORMULA [KEGG COMPOUND:] is_a: CHEBI:33659 ! organic aromatic compound is_a: CHEBI:50047 ! organic amino compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33861 name: transition element coordination entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "transition element coordination entities" RELATED [ChEBI:] synonym: "transition metal coordination compounds" RELATED [ChEBI:] synonym: "transition metal coordination entities" RELATED [ChEBI:] is_a: CHEBI:33240 ! coordination entity is_a: CHEBI:33497 ! transition element molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33862 name: platinum coordination entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "platinum coordination compounds" RELATED [ChEBI:] synonym: "platinum coordination entities" RELATED [ChEBI:] synonym: "platinum coordination entity" EXACT [ChEBI:] is_a: CHEBI:33749 ! platinum molecular entity is_a: CHEBI:33861 ! transition element coordination entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33892 name: iron coordination entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "iron coordination compounds" RELATED [ChEBI:] synonym: "iron coordination entities" RELATED [ChEBI:] synonym: "iron coordination entity" EXACT [ChEBI:] is_a: CHEBI:24873 ! iron molecular entity is_a: CHEBI:33861 ! transition element coordination entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33917 name: aldohexose namespace: chebi_ontology alt_id: CHEBI:2558 def: "A hexose with a (potential) aldehyde group at one end." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "Aldohexose" EXACT [KEGG COMPOUND:] synonym: "aldohexose" EXACT [ChEBI:] synonym: "aldohexoses" RELATED [ChEBI:] synonym: "C6H12O6" RELATED FORMULA [KEGG COMPOUND:] synonym: "InChI=1S/C6H12O6/c7-1-3(9)5(11)6(12)4(10)2-8/h1,3-6,8-12H,2H2" RELATED InChI [ChEBI:] synonym: "InChIKey=GZCGUPFRVQAUEE-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "OCC(O)C(O)C(O)C(O)C=O" RELATED SMILES [ChEBI:] xref: KEGG COMPOUND:C01662 "KEGG COMPOUND" is_a: CHEBI:15693 ! aldose is_a: CHEBI:18133 ! hexose property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:3392 name: carbendazim namespace: chebi_ontology def: "A member of the class of benzimidazoles that is 2-aminobenzimidazole in which the primary amino group is substituted by a methoxycarbonyl group. A fungicide, carbendazim controls Ascomycetes, Fungi Imperfecti, and Basidiomycetes on a wide variety of crops, including bananas, cereals, cotton, fruits, grapes, mushrooms, ornamentals, peanuts, sugarbeet, soybeans, tobacco, and vegetables." [] synonym: "1H-benzimidazol-2-ylcarbamic acid methyl ester" RELATED [ChEBI:] synonym: "2-(Methoxy-carbonylamino)-benzimidazol" RELATED [ChemIDplus:] synonym: "2-(methoxycarbonylamino)-benzimidazole" RELATED [ChemIDplus:] synonym: "2-(methoxycarbonylamino)benzimidazole" RELATED [ChEBI:] synonym: "2-benzimidazolecarbamic acid methyl ester" RELATED [ChEBI:] synonym: "BMC" RELATED [ChEBI:] synonym: "C9H9N3O2" RELATED FORMULA [ChEBI:] synonym: "Carbendazim" EXACT [KEGG COMPOUND:] synonym: "carbendazime" RELATED [ChemIDplus:] synonym: "COC(=O)Nc1nc2ccccc2[nH]1" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C9H9N3O2/c1-14-9(13)12-8-10-6-4-2-3-5-7(6)11-8/h2-5H,1H3,(H2,10,11,12,13)" RELATED InChI [ChEBI:] synonym: "InChIKey=TWFZGCMQGLPBSX-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "MBC" RELATED [ChEBI:] synonym: "Mecarzole" RELATED [KEGG COMPOUND:] synonym: "methyl 1H-benzimidazol-2-ylcarbamate" EXACT IUPAC_NAME [IUPAC:] synonym: "methyl 2-benzimidazolecarbamate" RELATED [ChemIDplus:] synonym: "methyl benzimidazol-2-ylcarbamate" RELATED [ChemIDplus:] xref: Alan Wood's Pesticides:carbendazim "Pesticides" xref: ChemIDplus:10605-21-7 "CAS Registry Number" xref: CiteXplore:20833408 "PubMed citation" xref: CiteXplore:21315898 "PubMed citation" xref: CiteXplore:22077925 "PubMed citation" xref: CiteXplore:22903170 "PubMed citation" xref: HMDB:HMDB31769 "HMDB" xref: KEGG COMPOUND:10605-21-7 "CAS Registry Number" xref: KEGG COMPOUND:C10897 "KEGG COMPOUND" xref: Patent:US3010968 "Patent" xref: Reaxys:649044 "Reaxys Registry Number" xref: Wikipedia:Carbendazim "Wikipedia" is_a: CHEBI:22715 ! benzimidazoles is_a: CHEBI:23003 ! carbamate ester property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33958 name: halide salt namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "halide salts" RELATED [ChEBI:] synonym: "halides" RELATED [ChEBI:] is_a: CHEBI:24866 ! salt is_a: CHEBI:37578 ! halide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33964 name: silver molecular entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "silver compounds" RELATED [ChEBI:] synonym: "silver molecular entities" RELATED [ChEBI:] synonym: "silver molecular entity" EXACT [ChEBI:] is_a: CHEBI:33745 ! copper group molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33966 name: elemental silver namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] is_a: CHEBI:33964 ! silver molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:33973 name: elemental magnesium namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] is_a: CHEBI:25108 ! magnesium molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:34630 name: chlorpropham namespace: chebi_ontology def: "A carbamate ester that is the isopropyl ester of 3-chlorophenylcarbamic acid." [] synonym: "(3-Chlorophenyl)carbamic acid, 1-methylethyl ester" RELATED [ChemIDplus:] synonym: "1-Methylethyl (3-chlorophenyl)carbamate" RELATED [ChemIDplus:] synonym: "3-Chlorocarbanilic acid, isopropyl ester" RELATED [ChemIDplus:] synonym: "C10H12ClNO2" RELATED FORMULA [ChEBI:] synonym: "CC(C)OC(=O)Nc1cccc(Cl)c1" RELATED SMILES [ChEBI:] synonym: "Chloropropham" RELATED [KEGG COMPOUND:] synonym: "Chlorpropham" EXACT [KEGG COMPOUND:] synonym: "Chlorprophame" RELATED [ChemIDplus:] synonym: "InChI=1S/C10H12ClNO2/c1-7(2)14-10(13)12-9-5-3-4-8(11)6-9/h3-7H,1-2H3,(H,12,13)" RELATED InChI [ChEBI:] synonym: "InChIKey=CWJSHJJYOPWUGX-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "isopropyl (3-chlorophenyl)carbamate" RELATED [IUPAC:] synonym: "Isopropyl 3-chlorocarbanilate" RELATED [ChemIDplus:] synonym: "Isopropyl 3-chlorophenylcarbamate" RELATED [ChemIDplus:] synonym: "Isopropyl m-chlorocarbanilate" RELATED [ChemIDplus:] synonym: "Isopropyl meta-chlorocarbanilate" RELATED [ChemIDplus:] synonym: "Isopropyl N-(3-chlorophenyl)carbamate" RELATED [ChemIDplus:] synonym: "Isopropyl N-(m-chlorophenyl)carbamate" RELATED [ChemIDplus:] synonym: "Isopropyl-m-chlorocarbanilate" RELATED [ChemIDplus:] synonym: "Isopropyl-N-(3-chlorophenyl)carbamate" RELATED [ChemIDplus:] synonym: "Isopropyl-N-(3-chlorphenyl)-carbamat" RELATED [ChemIDplus:] synonym: "Isopropyl-N-3-chlorophenyl carbamate" RELATED [ChemIDplus:] synonym: "Isopropyl-N-m-chlorophenyl-carbamate" RELATED [ChemIDplus:] synonym: "m-Chlorocarbanilic acid isopropyl ester" RELATED [NIST Chemistry WebBook:] synonym: "m-Chlorocarbanilic acid, isopropyl ester" RELATED [ChemIDplus:] synonym: "N-(3-Chlorophenyl)carbamic acid, isopropyl ester" RELATED [ChemIDplus:] synonym: "N-(3-Chlorophenyl)isopropyl carbamate" RELATED [NIST Chemistry WebBook:] synonym: "N-3-Chlorophenylisopropylcarbamate" RELATED [ChemIDplus:] synonym: "N-3-Chlorophenylisopropylcarbamate" RELATED [KEGG COMPOUND:] synonym: "O-Isopropyl N-(3-chlorophenyl)carbamate" RELATED [ChemIDplus:] synonym: "propan-2-yl (3-chlorophenyl)carbamate" EXACT IUPAC_NAME [IUPAC:] xref: ChemIDplus:101-21-3 "CAS Registry Number" xref: ChemIDplus:2211397 "Beilstein Registry Number" xref: CiteXplore:21757399 "PubMed citation" xref: CiteXplore:22753523 "PubMed citation" xref: CiteXplore:22982221 "PubMed citation" xref: CiteXplore:23295769 "PubMed citation" xref: CiteXplore:23674283 "PubMed citation" xref: CiteXplore:23708426 "PubMed citation" xref: CiteXplore:24166079 "PubMed citation" xref: KEGG COMPOUND:101-21-3 "CAS Registry Number" xref: KEGG COMPOUND:C14506 "KEGG COMPOUND" xref: NIST Chemistry WebBook:101-21-3 "CAS Registry Number" xref: Reaxys:2211397 "Reaxys Registry Number" xref: Wikipedia:Chlorpropham "Wikipedia" is_a: CHEBI:23003 ! carbamate ester is_a: CHEBI:83403 ! monochlorobenzenes property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:34779 name: glyoxal namespace: chebi_ontology def: "The dialdehyde that is the smallest possible and which consists of ethane having oxo groups on both carbons." [] synonym: "1,2-Ethanedione" RELATED [ChemIDplus:] synonym: "1,2-Ethanedione" RELATED [KEGG COMPOUND:] synonym: "[H]C(=O)C([H])=O" RELATED SMILES [ChEBI:] synonym: "Biformal" RELATED [ChemIDplus:] synonym: "Biformyl" RELATED [ChemIDplus:] synonym: "C2H2O2" RELATED FORMULA [ChEBI:] synonym: "Diformal" RELATED [ChemIDplus:] synonym: "Diformyl" RELATED [ChemIDplus:] synonym: "ethane-1,2-dial" RELATED [ChEBI:] synonym: "Ethanedial" RELATED [ChemIDplus:] synonym: "ethanedial" EXACT IUPAC_NAME [IUPAC:] synonym: "glyoxal aldehyde" RELATED [NIST Chemistry WebBook:] synonym: "glyoxylaldehyde" RELATED [NIST Chemistry WebBook:] synonym: "InChI=1S/C2H2O2/c3-1-2-4/h1-2H" RELATED InChI [ChEBI:] synonym: "InChIKey=LEQAOMBKQFMDFZ-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "oxal" RELATED [ChEBI:] synonym: "Oxalaldehyde" RELATED [ChemIDplus:] xref: ChemIDplus:107-22-2 "CAS Registry Number" xref: ChemIDplus:1732463 "Beilstein Registry Number" xref: CiteXplore:11833298 "PubMed citation" xref: CiteXplore:15899002 "PubMed citation" xref: CiteXplore:18343213 "PubMed citation" xref: CiteXplore:18533367 "PubMed citation" xref: CiteXplore:23180757 "PubMed citation" xref: CiteXplore:23531876 "PubMed citation" xref: CiteXplore:23543734 "PubMed citation" xref: CiteXplore:23990306 "PubMed citation" xref: CiteXplore:9506998 "PubMed citation" xref: KEGG COMPOUND:107-22-2 "CAS Registry Number" xref: KEGG COMPOUND:C14448 "KEGG COMPOUND" xref: NIST Chemistry WebBook:107-22-2 "CAS Registry Number" xref: Reaxys:1732463 "Reaxys Registry Number" xref: Wikipedia:Glyoxal "Wikipedia" is_a: CHEBI:38124 ! dialdehyde property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:34848 name: mevastatin namespace: chebi_ontology def: "A carboxylic ester that is pravastatin that is lacking the allylic hydroxy group and in which the lactone moiety has been hydrolysed to the corresponding delta-hydroxy-carboxylic acid. A hydroxymethylglutaryl-CoA reductase inhibitor (statin) isolated from Penicillium citrinum and from Penicillium brevicompactum, its clinical use as a lipid-regulating drug ceased following reports of toxicity in animals." [] synonym: "(1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate" EXACT IUPAC_NAME [IUPAC:] synonym: "antibiotic ML 236B" RELATED [ChemIDplus:] synonym: "C23H34O5" RELATED FORMULA [ChEBI:] synonym: "CC[C@H](C)C(=O)O[C@H]1CCC=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12" RELATED SMILES [ChEBI:] synonym: "Compactin" RELATED [KEGG COMPOUND:] synonym: "CS 500" RELATED [ChemIDplus:] synonym: "InChI=1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=AJLFOPYRIVGYMJ-INTXDZFKSA-N" RELATED InChIKey [ChEBI:] synonym: "Mevastatin" EXACT [KEGG COMPOUND:] synonym: "mevastatin" RELATED INN [WHO MedNet:] synonym: "mevastatina" RELATED INN [WHO MedNet:] synonym: "mevastatine" RELATED INN [WHO MedNet:] synonym: "mevastatinum" RELATED INN [WHO MedNet:] synonym: "ML 236 B" RELATED [ChemIDplus:] synonym: "ML-236B" RELATED [KEGG COMPOUND:] xref: ChemIDplus:73573-88-3 "CAS Registry Number" xref: CiteXplore:11283400 "PubMed citation" xref: CiteXplore:12403272 "PubMed citation" xref: CiteXplore:15274361 "PubMed citation" xref: CiteXplore:15531285 "PubMed citation" xref: CiteXplore:15786722 "PubMed citation" xref: CiteXplore:18672387 "PubMed citation" xref: CiteXplore:18936176 "PubMed citation" xref: CiteXplore:20629200 "PubMed citation" xref: CiteXplore:23918904 "PubMed citation" xref: CiteXplore:24462564 "PubMed citation" xref: CiteXplore:3170348 "PubMed citation" xref: CiteXplore:3719857 "PubMed citation" xref: DrugBank:DB06693 "DrugBank" xref: KEGG COMPOUND:73573-88-3 "CAS Registry Number" xref: KEGG COMPOUND:C13963 "KEGG COMPOUND" xref: KNApSAcK:C00000564 "KNApSAcK" xref: Patent:DE2524355 "Patent" xref: Patent:US3983140 "Patent" xref: Reaxys:3630717 "Reaxys Registry Number" xref: Wikipedia:Mevastatin "Wikipedia" is_a: CHEBI:18946 ! delta-lactone is_a: CHEBI:36785 ! carbobicyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:34892 name: nocodazole namespace: chebi_ontology def: "A member of the class of benzimidazoles that is benzimidalole which is substituted at position 2 by a (methoxycarbonyl)amino group and at position 5 by a 2-thienoyl group. It is an antineoplastic agent that exerts its effect by depolymerising microtubules." [] synonym: "(5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-carbamic acid methyl ester" RELATED [ChemIDplus:] synonym: "C14H11N3O3S" RELATED FORMULA [ChEBI:] synonym: "COC(=O)Nc1nc2cc(ccc2[nH]1)C(=O)c1cccs1" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)" RELATED InChI [ChEBI:] synonym: "InChIKey=KYRVNWMVYQXFEU-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "methyl (5-(2-thienylcarbonyl))-1H-benzimidazole-2-ylcarbamate" RELATED [ChemIDplus:] synonym: "methyl [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate" EXACT IUPAC_NAME [IUPAC:] synonym: "methyl N-(5-thenoyl-2-benzimidazolyl)carbamate" RELATED [NIST Chemistry WebBook:] synonym: "N-(5-(2-thenoyl)-2-benzimidazolyl)carbamic acid methyl ester" RELATED [ChemIDplus:] synonym: "N-(5-(2-thienoyl)-2-benzimidazolyl)carbamic acid methyl ester" RELATED [NIST Chemistry WebBook:] synonym: "nocodazol" RELATED INN [ChemIDplus:] synonym: "Nocodazole" EXACT [KEGG COMPOUND:] synonym: "nocodazole" RELATED INN [KEGG DRUG:] synonym: "nocodazole" RELATED INN [WHO MedNet:] synonym: "nocodazolum" RELATED INN [ChemIDplus:] synonym: "oncobendazole" RELATED [ChEBI:] synonym: "oncodazole" RELATED [ChemIDplus:] synonym: "R 17934" RELATED [ChemIDplus:] synonym: "R-17934" RELATED [ChEBI:] synonym: "R17,934" RELATED [ChemIDplus:] xref: Beilstein:1085978 "Beilstein Registry Number" xref: ChemIDplus:31430-18-9 "CAS Registry Number" xref: CiteXplore:11679255 "PubMed citation" xref: CiteXplore:20399776 "PubMed citation" xref: CiteXplore:22002881 "PubMed citation" xref: CiteXplore:23869451 "PubMed citation" xref: CiteXplore:518692 "PubMed citation" xref: CiteXplore:6384770 "PubMed citation" xref: CiteXplore:7199049 "PubMed citation" xref: CiteXplore:7284368 "PubMed citation" xref: CiteXplore:7344613 "PubMed citation" xref: DrugBank:DB08313 "DrugBank" xref: KEGG COMPOUND:31430-18-9 "CAS Registry Number" xref: KEGG COMPOUND:C13719 "KEGG COMPOUND" xref: KEGG DRUG:D05197 "KEGG DRUG" xref: NIST Chemistry WebBook:31430-18-9 "CAS Registry Number" xref: PDBeChem:NZO "PDBeChem" xref: Reaxys:1085978 "Reaxys Registry Number" xref: Wikipedia:Nocodazole "Wikipedia" is_a: CHEBI:22715 ! benzimidazoles is_a: CHEBI:23003 ! carbamate ester is_a: CHEBI:26961 ! thiophenes is_a: CHEBI:76224 ! aromatic ketone property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:34905 name: paraquat namespace: chebi_ontology def: "An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions." [] synonym: "1,1'-Dimethyl-4,4'-bipyridinium" RELATED [KEGG COMPOUND:] synonym: "1,1'-dimethyl-4,4'-bipyridyldiylium" RELATED [ChemIDplus:] synonym: "1,1'-dimethyl-[4,4'-bipyridin]-1,1'-diium" EXACT IUPAC_NAME [IUPAC:] synonym: "C12H14N2" RELATED FORMULA [KEGG COMPOUND:] synonym: "C[n+]1ccc(cc1)-c1cc[n+](C)cc1" RELATED SMILES [ChEBI:] synonym: "dimethyl viologen" RELATED [ChemIDplus:] synonym: "InChI=1S/C12H14N2/c1-13-7-3-11(4-8-13)12-5-9-14(2)10-6-12/h3-10H,1-2H3/q+2" RELATED InChI [ChEBI:] synonym: "InChIKey=INFDPOAKFNIJBF-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "methyl viologen ion(2+)" RELATED [ChemIDplus:] synonym: "N,N'-dimethyl-4,4'-bipyridinium" RELATED [ChemIDplus:] synonym: "N,N'-dimethyl-4,4'-bipyridinium dication" RELATED [ChemIDplus:] synonym: "Paraquat" EXACT [KEGG COMPOUND:] synonym: "paraquat dication" RELATED [ChemIDplus:] synonym: "paraquat ion" RELATED [ChemIDplus:] xref: Beilstein:3590305 "Beilstein Registry Number" xref: ChemIDplus:4685-14-7 "CAS Registry Number" xref: CiteXplore:11349957 "PubMed citation" xref: CiteXplore:18620719 "PubMed citation" xref: CiteXplore:20377249 "PubMed citation" xref: CiteXplore:20582739 "PubMed citation" xref: CiteXplore:21236547 "PubMed citation" xref: CiteXplore:21300143 "PubMed citation" xref: CiteXplore:21318114 "PubMed citation" xref: CiteXplore:21429624 "PubMed citation" xref: CiteXplore:21493003 "PubMed citation" xref: CiteXplore:21598522 "PubMed citation" xref: CiteXplore:21616728 "PubMed citation" xref: CiteXplore:21619794 "PubMed citation" xref: CiteXplore:21619822 "PubMed citation" xref: CiteXplore:21750730 "PubMed citation" xref: CiteXplore:21777615 "PubMed citation" xref: CiteXplore:21787677 "PubMed citation" xref: CiteXplore:21802509 "PubMed citation" xref: Gmelin:51125 "Gmelin Registry Number" xref: KEGG COMPOUND:4685-14-7 "CAS Registry Number" xref: KEGG COMPOUND:C14701 "KEGG COMPOUND" xref: NIST Chemistry WebBook:4685-14-7 "CAS Registry Number" xref: Reaxys:3590305 "Reaxys Registry Number" is_a: CHEBI:25697 ! organic cation property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35106 name: nitrogen hydride namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "nitrogen hydrides" RELATED [ChEBI:] is_a: CHEBI:35881 ! pnictogen hydride is_a: CHEBI:51143 ! nitrogen molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35107 name: azane namespace: chebi_ontology def: "Saturated acyclic nitrogen hydrides having the general formula NnHn+2." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "azanes" RELATED [ChEBI:] is_a: CHEBI:35106 ! nitrogen hydride property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35113 name: elemental mercury namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] is_a: CHEBI:25196 ! mercury molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35115 name: elemental manganese namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] is_a: CHEBI:25154 ! manganese molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35131 name: aldose phosphate namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "aldose phosphates" RELATED [ChEBI:] is_a: CHEBI:33447 ! phospho sugar property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35155 name: elemental calcium namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] is_a: CHEBI:22985 ! calcium molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35158 name: ribose bisphosphate namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "ribose bisphosphate" EXACT [ChEBI:] synonym: "ribose bisphosphates" RELATED [ChEBI:] is_a: CHEBI:26562 ! ribose phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35166 name: vanadium coordination entity namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "vanadium coordination compounds" RELATED [ChEBI:] synonym: "vanadium coordination entities" RELATED [ChEBI:] synonym: "vanadium coordination entity" EXACT [ChEBI:] is_a: CHEBI:27275 ! vanadium molecular entity is_a: CHEBI:33861 ! transition element coordination entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35186 name: terpene namespace: chebi_ontology def: "A hydrocarbon of biological origin having carbon skeleton formally derived from isoprene [CH2=C(CH3)CH=CH2]." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "Terpen" RELATED [ChEBI:] synonym: "terpene" EXACT [IUPAC:] synonym: "terpenes" EXACT IUPAC_NAME [IUPAC:] synonym: "terpenes" RELATED [IUPAC:] synonym: "terpeno" RELATED [IUPAC:] synonym: "terpenos" RELATED [IUPAC:] is_a: CHEBI:24632 ! hydrocarbon is_a: CHEBI:24913 ! isoprenoid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35191 name: triterpene namespace: chebi_ontology def: "A C30 terpene." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "Triterpen" RELATED [ChEBI:] synonym: "triterpenes" EXACT IUPAC_NAME [IUPAC:] synonym: "triterpenes" RELATED [IUPAC:] synonym: "triterpeno" RELATED [IUPAC:] synonym: "triterpenos" RELATED [IUPAC:] is_a: CHEBI:35186 ! terpene property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35196 name: nitrogen oxide namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "nitrogen oxides" RELATED [ChEBI:] synonym: "oxides of nitrogen" RELATED [ChEBI:] is_a: CHEBI:24836 ! inorganic oxide is_a: CHEBI:51143 ! nitrogen molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35213 name: cyclodepsipeptide namespace: chebi_ontology def: "A depsipeptide in which the amino and hydroxy carboxylic acid residues are connected in a ring." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "Cyclodepsipeptid" RELATED [ChEBI:] synonym: "cyclodepsipeptides" EXACT IUPAC_NAME [IUPAC:] synonym: "Zyklodepsipeptid" RELATED [ChEBI:] is_a: CHEBI:23643 ! depsipeptide is_a: CHEBI:25000 ! lactone property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35222 name: inhibitor namespace: chebi_ontology def: "A substance that diminishes the rate of a chemical reaction." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "inhibidor" RELATED [ChEBI:] synonym: "inhibiteur" RELATED [ChEBI:] synonym: "inhibitor" EXACT IUPAC_NAME [IUPAC:] synonym: "inhibitors" RELATED [ChEBI:] is_a: CHEBI:51086 ! chemical role property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35259 name: benzofurans namespace: chebi_ontology alt_id: CHEBI:22721 synonym: "benzofurans" EXACT [ChEBI:] is_a: CHEBI:38104 ! oxacycle is_a: CHEBI:38166 ! organic heteropolycyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35267 name: quaternary ammonium ion namespace: chebi_ontology alt_id: CHEBI:26470 alt_id: CHEBI:8693 def: "A derivative of ammonium, NH4(+), in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually hydrocarbyl) groups." [] synonym: "[*][N+]([*])([*])[*]" RELATED SMILES [ChEBI:] synonym: "NR4" RELATED FORMULA [ChEBI:] synonym: "Quaternary amine" RELATED [KEGG COMPOUND:] synonym: "quaternary ammonium" RELATED [UniProt:] synonym: "quaternary ammonium ion" EXACT IUPAC_NAME [IUPAC:] synonym: "quaternary ammonium ions" RELATED [ChEBI:] xref: KEGG COMPOUND:C06703 "KEGG COMPOUND" is_a: CHEBI:35274 ! ammonium ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35274 name: ammonium ion namespace: chebi_ontology def: "Ammonium, NH4(+), and derivatives formed by substitution by univalent groups." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "ammonium ions" RELATED [ChEBI:] synonym: "azanium ions" RELATED [ChEBI:] is_a: CHEBI:33702 ! polyatomic cation is_a: CHEBI:51143 ! nitrogen molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35281 name: onium betaine namespace: chebi_ontology def: "Neutral molecules having charge-separated forms with an onium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "betaines" EXACT IUPAC_NAME [IUPAC:] synonym: "onium betaines" RELATED [ChEBI:] is_a: CHEBI:27369 ! zwitterion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35284 name: ammonium betaine namespace: chebi_ontology def: "Any neutral molecule having charge-separated forms with a quaternary ammonium atom which bears no hydrogen atoms and that is not adjacent to the anionic atom." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "ammonium betaines" RELATED [ChEBI:] is_a: CHEBI:26469 ! quaternary nitrogen compound is_a: CHEBI:35281 ! onium betaine property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35294 name: carbopolycyclic compound namespace: chebi_ontology def: "A polyclic compound in which all of the ring members are carbon atoms." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "carbopolycyclic compounds" RELATED [ChEBI:] is_a: CHEBI:33598 ! carbocyclic compound is_a: CHEBI:35295 ! homopolycyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35295 name: homopolycyclic compound namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "homopolycyclic compounds" RELATED [ChEBI:] is_a: CHEBI:33597 ! homocyclic compound is_a: CHEBI:33635 ! polycyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35313 name: hexoside namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "hexoside" EXACT [ChEBI:] synonym: "hexosides" RELATED [ChEBI:] is_a: CHEBI:24400 ! glycoside property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35315 name: deoxy hexoside namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "deoxy hexoside" EXACT [ChEBI:] synonym: "deoxy hexosides" RELATED [ChEBI:] is_a: CHEBI:24400 ! glycoside property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35341 name: steroid namespace: chebi_ontology alt_id: CHEBI:13687 alt_id: CHEBI:26768 alt_id: CHEBI:9263 def: "Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from triterpenoids." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "a steroid" RELATED [UniProt:] synonym: "Steroid" EXACT [KEGG COMPOUND:] synonym: "steroids" EXACT IUPAC_NAME [IUPAC:] xref: KEGG COMPOUND:C00377 "KEGG COMPOUND" is_a: CHEBI:18059 ! lipid is_a: CHEBI:51958 ! organic polycyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35348 name: 3beta-sterol namespace: chebi_ontology alt_id: CHEBI:1725 alt_id: CHEBI:20248 synonym: "3beta-Hydroxysteroid" RELATED [KEGG COMPOUND:] synonym: "3beta-hydroxysteroids" RELATED [ChEBI:] synonym: "3beta-sterols" RELATED [ChEBI:] xref: KEGG COMPOUND:C02945 "KEGG COMPOUND" is_a: CHEBI:15889 ! sterol is_a: CHEBI:36836 ! 3beta-hydroxy steroid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35350 name: hydroxy steroid namespace: chebi_ontology alt_id: CHEBI:24748 alt_id: CHEBI:5814 synonym: "hydroxy steroids" RELATED [ChEBI:] synonym: "Hydroxysteroid" RELATED [KEGG COMPOUND:] synonym: "hydroxysteroids" RELATED [ChEBI:] xref: KEGG COMPOUND:C02159 "KEGG COMPOUND" is_a: CHEBI:30879 ! alcohol is_a: CHEBI:35341 ! steroid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35352 name: organonitrogen compound namespace: chebi_ontology def: "Any heteroorganic entity containing at least one carbon-nitrogen bond." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "organonitrogen compounds" EXACT IUPAC_NAME [IUPAC:] synonym: "organonitrogens" RELATED [ChEBI:] is_a: CHEBI:33285 ! heteroorganic entity is_a: CHEBI:51143 ! nitrogen molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35356 name: dicarboximide namespace: chebi_ontology def: "An imide in which the two acyl substituents on nitrogen are carboacyl groups." [] synonym: "[*]N(C([*])=O)C([*])=O" RELATED SMILES [ChEBI:] synonym: "C2NO2R3" RELATED FORMULA [ChEBI:] synonym: "dicarboximides" RELATED [ChEBI:] synonym: "secondary carboxamide" RELATED [ChEBI:] is_a: CHEBI:24782 ! imide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35358 name: sulfonamide namespace: chebi_ontology def: "An amide of a sulfonic acid RS(=O)2NR'2." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "[*]S(=O)(=O)N([*])[*]" RELATED SMILES [ChEBI:] synonym: "NO2SR3" RELATED FORMULA [ChEBI:] synonym: "sulfonamides" EXACT IUPAC_NAME [IUPAC:] synonym: "sulfonamides" RELATED [ChEBI:] xref: CiteXplore:2434548 "PubMed citation" is_a: CHEBI:33256 ! primary amide is_a: CHEBI:33552 ! sulfonic acid derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35366 name: fatty acid namespace: chebi_ontology alt_id: CHEBI:13633 alt_id: CHEBI:24024 alt_id: CHEBI:4984 def: "Any aliphatic monocarboxylic acid derived from or contained in esterified form in an animal or vegetable fat, oil or wax." [] synonym: "acide gras" RELATED [ChEBI:] synonym: "acides gras" RELATED [ChemIDplus:] synonym: "acido graso" RELATED [ChEBI:] synonym: "acidos grasos" RELATED [ChEBI:] synonym: "CHO2R" RELATED FORMULA [ChEBI:] synonym: "Fatty acid" EXACT [KEGG COMPOUND:] synonym: "fatty acids" EXACT IUPAC_NAME [IUPAC:] synonym: "fatty acids" RELATED [ChEBI:] synonym: "Fettsaeure" RELATED [ChEBI:] synonym: "Fettsaeuren" RELATED [ChEBI:] synonym: "OC([*])=O" RELATED SMILES [ChEBI:] xref: CiteXplore:14287444 "PubMed citation" xref: CiteXplore:14300208 "PubMed citation" xref: CiteXplore:14328676 "PubMed citation" xref: KEGG COMPOUND:C00162 "KEGG COMPOUND" xref: Wikipedia:Fatty_acid "Wikipedia" is_a: CHEBI:18059 ! lipid is_a: CHEBI:25384 ! monocarboxylic acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35381 name: monosaccharide namespace: chebi_ontology alt_id: CHEBI:25407 alt_id: CHEBI:6984 def: "Parent monosaccharides are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H-[CHOH]n-C(=O)[CHOH]m-H with three or more carbon atoms. The generic term 'monosaccharide' (as opposed to oligosaccharide or polysaccharide) denotes a single unit, without glycosidic connection to other such units. It includes aldoses, dialdoses, aldoketoses, ketoses and diketoses, as well as deoxy sugars, provided that the parent compound has a (potential) carbonyl group." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "monosacarido" RELATED [ChEBI:] synonym: "monosacaridos" RELATED [IUPAC:] synonym: "Monosaccharid" RELATED [ChEBI:] synonym: "Monosaccharide" EXACT [KEGG COMPOUND:] synonym: "monosaccharide" EXACT [UniProt:] synonym: "monosaccharides" EXACT IUPAC_NAME [IUPAC:] synonym: "Monosacharid" RELATED [ChEBI:] xref: KEGG COMPOUND:C06698 "KEGG COMPOUND" is_a: CHEBI:16646 ! carbohydrate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35405 name: transition element oxoanion namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "transition element oxoanions" RELATED [ChEBI:] synonym: "transition metal oxoanion" RELATED [ChEBI:] synonym: "transition metal oxoanions" RELATED [ChEBI:] is_a: CHEBI:24834 ! inorganic anion is_a: CHEBI:33861 ! transition element coordination entity is_a: CHEBI:35406 ! oxoanion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35406 name: oxoanion namespace: chebi_ontology alt_id: CHEBI:33274 alt_id: CHEBI:33436 def: "An oxoanion is an anion derived from an oxoacid by loss of hydron(s) bound to oxygen." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "oxoacid anions" RELATED [ChEBI:] synonym: "oxoanion" EXACT [ChEBI:] synonym: "oxoanions" RELATED [ChEBI:] is_a: CHEBI:25741 ! oxide is_a: CHEBI:33273 ! polyatomic anion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35436 name: D-glucoside namespace: chebi_ontology alt_id: CHEBI:21009 alt_id: CHEBI:4173 synonym: "C6H11O6R" RELATED FORMULA [KEGG COMPOUND:] synonym: "D-Glucoside" EXACT [KEGG COMPOUND:] synonym: "D-glucosides" RELATED [ChEBI:] synonym: "OC[C@H]1OC(O[*])[C@H](O)[C@@H](O)[C@@H]1O" RELATED SMILES [ChEBI:] xref: KEGG COMPOUND:C01798 "KEGG COMPOUND" is_a: CHEBI:24278 ! glucoside property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35479 name: alkali metal salt namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "alkali metal salts" RELATED [ChEBI:] is_a: CHEBI:24866 ! salt is_a: CHEBI:33296 ! alkali metal molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35486 name: maleate ester namespace: chebi_ontology def: "Compounds of the general formula ROOC-CH=CH-COOR' where R and R' are organyl groups" [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "maleate esters" RELATED [ChEBI:] is_a: CHEBI:51702 ! enoate ester property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35489 name: organic disulfide namespace: chebi_ontology def: "Compounds of structure RSSR in which R and R' are organic groups." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "[*]SS[*]" RELATED SMILES [ChEBI:] synonym: "disulfides" EXACT IUPAC_NAME [IUPAC:] synonym: "organic disulfides" RELATED [ChEBI:] synonym: "S2R2" RELATED FORMULA [ChEBI:] is_a: CHEBI:33261 ! organosulfur compound is_a: CHEBI:48343 ! disulfide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35496 name: fluorobenzenes namespace: chebi_ontology def: "Any fluoroarene that is a benzene or a substituted benzene carrying at least one fluoro group." [] synonym: "." RELATED FORMULA [ChEBI:] is_a: CHEBI:22712 ! benzenes is_a: CHEBI:37143 ! organofluorine compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35504 name: addition compound namespace: chebi_ontology def: "An addition compound contains two or more simpler compounds that can be packed in a definite ratio into a crystal. The term covers donor-acceptor complexes (adducts) and a variety of lattice compounds." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "addition compounds" RELATED [ChEBI:] is_a: CHEBI:37577 ! heteroatomic molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35505 name: hydrate namespace: chebi_ontology def: "An addition compound that contains water in weak chemical combination with another compound." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "hidrato" RELATED [ChEBI:] synonym: "hidratos" RELATED [ChEBI:] synonym: "Hydrat" RELATED [ChEBI:] synonym: "hydrates" RELATED [ChEBI:] is_a: CHEBI:35504 ! addition compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35552 name: heterocyclic organic fundamental parent namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "heterocyclic fundamental parent" RELATED [ChEBI:] synonym: "heterocyclic organic fundamental parents" RELATED [ChEBI:] synonym: "heterocyclic parent hydrides" EXACT IUPAC_NAME [IUPAC:] synonym: "organic heterocyclic fundamental parents" RELATED [ChEBI:] is_a: CHEBI:33245 ! organic fundamental parent property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35568 name: mancude ring namespace: chebi_ontology def: "Any molecular entity that consists of a ring having (formally) the maximum number of noncumulative double bonds." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "mancude rings" RELATED [ChEBI:] synonym: "mancude-ring systems" EXACT IUPAC_NAME [IUPAC:] synonym: "mancunide-ring systems" RELATED [IUPAC:] is_a: CHEBI:23367 ! molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35570 name: mancude organic heterobicyclic parent namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "mancude organic heterobicyclic parents" RELATED [ChEBI:] synonym: "mancude-ring organic heterobicyclic parents" RELATED [ChEBI:] is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:35571 ! mancude organic heterocyclic parent property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35571 name: mancude organic heterocyclic parent namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "mancude organic heterocyclic parents" RELATED [ChEBI:] synonym: "mancude-ring organic heterocyclic parents" RELATED [ChEBI:] is_a: CHEBI:35552 ! heterocyclic organic fundamental parent is_a: CHEBI:35573 ! organic mancude parent property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35573 name: organic mancude parent namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "organic mancude parents" RELATED [ChEBI:] synonym: "organic mancude-ring parents" RELATED [ChEBI:] is_a: CHEBI:33245 ! organic fundamental parent is_a: CHEBI:35568 ! mancude ring property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35580 name: N-oxide namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "N-oxide" EXACT [ChEBI:] synonym: "N-oxides" RELATED [ChEBI:] is_a: CHEBI:25741 ! oxide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35584 name: purine namespace: chebi_ontology def: "A heterobicyclic aromatic organic compound comprising a pyrimidine ring fused to an imidazole ring; the parent compound of the purines." [] synonym: "C5H4N4" RELATED FORMULA [ChEBI:] synonym: "purine" EXACT IUPAC_NAME [IUPAC:] xref: CiteXplore:12865945 "PubMed citation" xref: CiteXplore:24088627 "PubMed citation" xref: HMDB:HMDB01366 "HMDB" xref: KEGG COMPOUND:C15587 "KEGG COMPOUND" xref: MetaCyc:PURINE "MetaCyc" is_a: CHEBI:26401 ! purines is_a: CHEBI:35570 ! mancude organic heterobicyclic parent property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35605 name: carbon oxoacid namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "carbon oxoacids" RELATED [ChEBI:] synonym: "oxoacids of carbon" RELATED [ChEBI:] is_a: CHEBI:24833 ! oxoacid is_a: CHEBI:36963 ! organooxygen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35607 name: trisodium vanadate namespace: chebi_ontology alt_id: CHEBI:475853 def: "An inorganic sodium salt of formula Na3VO4 containing the tetrahedral VO4(3-)" [] synonym: "[Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/3Na.4O.V/q3*+1;;3*-1;" RELATED InChI [ChEBI:] synonym: "InChIKey=IHIXIJGXTJIKRB-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "Na3O4V" RELATED FORMULA [ChEBI:] synonym: "Na3VO4" RELATED [IUPAC:] synonym: "sodium o-vanadate" RELATED [ChemIDplus:] synonym: "sodium pervanadate" RELATED [ChemIDplus:] synonym: "sodium tetraoxidovanadate(3-)" EXACT IUPAC_NAME [IUPAC:] synonym: "sodium tetraoxidovanadate(V)" EXACT IUPAC_NAME [IUPAC:] synonym: "sodium tetraoxovanadate(3-)" RELATED [ChemIDplus:] synonym: "sodium vanadate" RELATED [ChemIDplus:] synonym: "sodium vanadate (ortho)" RELATED [ChemIDplus:] synonym: "sodium vanadate(V)" RELATED [ChemIDplus:] synonym: "sodium vanadium oxide" RELATED [ChemIDplus:] synonym: "trisodium orthovanadate" RELATED [ChemIDplus:] synonym: "trisodium tetraoxovanadate" RELATED [ChemIDplus:] synonym: "trisodium trioxido(oxo)vanadium" RELATED [ChEBI:] synonym: "trisodium vanadate" EXACT [ChemIDplus:] synonym: "vanadate (VO4(3-)), trisodium" RELATED [ChemIDplus:] synonym: "vanadic acid (H3VO4), sodium salt" RELATED [ChemIDplus:] synonym: "vanadic acid, trisodium salt" RELATED [ChemIDplus:] xref: Beilstein:12153548 "Beilstein Registry Number" xref: ChemIDplus:13721-39-6 "CAS Registry Number" xref: CiteXplore:21909513 "PubMed citation" xref: Gmelin:1600790 "Gmelin Registry Number" xref: Gmelin:2388949 "Gmelin Registry Number" xref: Gmelin:2389118 "Gmelin Registry Number" xref: Gmelin:38128 "Gmelin Registry Number" xref: Reaxys:14555683 "Reaxys Registry Number" xref: Wikipedia:Sodium_orthovanadate "Wikipedia" is_a: CHEBI:38702 ! inorganic sodium salt property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35618 name: aromatic ether namespace: chebi_ontology def: "Any ether in which the oxygen is attached to at least one aryl substituent." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "aromatic ethers" RELATED [ChEBI:] is_a: CHEBI:25698 ! ether is_a: CHEBI:33659 ! organic aromatic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35622 name: thiazolidines namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "thiazolidine" RELATED [ChEBI:] is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound is_a: CHEBI:38106 ! organosulfur heterocyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35676 name: benzazepine namespace: chebi_ontology def: "A group of two-ring heterocyclic compounds consisting of a benzene ring fused to an azepine ring." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "benzazepine" EXACT [ChEBI:] synonym: "benzazepines" RELATED [ChEBI:] synonym: "benzoazepines" RELATED [ChEBI:] is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35681 name: secondary alcohol namespace: chebi_ontology alt_id: CHEBI:13425 alt_id: CHEBI:13686 alt_id: CHEBI:26617 alt_id: CHEBI:58662 alt_id: CHEBI:8741 alt_id: CHEBI:9077 def: "A secondary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has two other carbon atoms attached to it." [] synonym: "a secondary alcohol" RELATED [UniProt:] synonym: "CH2OR2" RELATED FORMULA [ChEBI:] synonym: "OC([*])[*]" RELATED SMILES [ChEBI:] synonym: "R-CHOH-R'" RELATED [KEGG COMPOUND:] synonym: "Secondary alcohol" EXACT [KEGG COMPOUND:] synonym: "secondary alcohols" RELATED [ChEBI:] xref: KEGG COMPOUND:C00432 "KEGG COMPOUND" xref: KEGG COMPOUND:C01612 "KEGG COMPOUND" is_a: CHEBI:30879 ! alcohol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35692 name: dicarboxylic acid namespace: chebi_ontology alt_id: CHEBI:23692 alt_id: CHEBI:36172 alt_id: CHEBI:4501 def: "An oxoacid containing two carboxy groups." [] synonym: "Dicarboxylic acid" EXACT [KEGG COMPOUND:] synonym: "dicarboxylic acids" RELATED [ChEBI:] xref: KEGG COMPOUND:C02028 "KEGG COMPOUND" is_a: CHEBI:33575 ! carboxylic acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35693 name: dicarboxylic acid anion namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "dicarboxylic acid anion" EXACT [ChEBI:] synonym: "dicarboxylic acid anions" RELATED [ChEBI:] is_a: CHEBI:29067 ! carboxylic acid anion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35701 name: ester namespace: chebi_ontology alt_id: CHEBI:23960 alt_id: CHEBI:4859 def: "A compound formally derived from an oxoacid RkE(=O)l(OH)m (l > 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "[*]OC([*])=O" RELATED SMILES [ChEBI:] synonym: "Ester" EXACT [KEGG COMPOUND:] synonym: "esters" RELATED [ChEBI:] xref: KEGG COMPOUND:C00287 "KEGG COMPOUND" is_a: CHEBI:36963 ! organooxygen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35715 name: nitro compound namespace: chebi_ontology def: "A compound having a nitro group, -NO2 (free valence on nitrogen), which may be attached to carbon, nitrogen (as in nitramines), or oxygen (as in nitrates), among other elements (in the absence of specification, C-nitro compounds are usually implied)." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "nitro compounds" EXACT IUPAC_NAME [IUPAC:] is_a: CHEBI:51143 ! nitrogen molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35716 name: C-nitro compound namespace: chebi_ontology def: "A nitro compound having the nitro group (-NO2) attached to a carbon atom." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "C-nitro compounds" EXACT IUPAC_NAME [IUPAC:] is_a: CHEBI:35715 ! nitro compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35727 name: triazoles namespace: chebi_ontology def: "An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "triazole compounds" RELATED [ChEBI:] is_a: CHEBI:68452 ! azole property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35735 name: dicarboxylic acid monoamide namespace: chebi_ontology alt_id: CHEBI:13210 alt_id: CHEBI:23691 alt_id: CHEBI:6976 synonym: "C2H3NO3(CH2)n" RELATED FORMULA [KEGG COMPOUND:] synonym: "dicarboxylic acid monoamide" EXACT [UniProt:] synonym: "dicarboxylic acid monoamides" RELATED [ChEBI:] synonym: "Monoamide of a dicarboxylic acid" RELATED [KEGG COMPOUND:] xref: KEGG COMPOUND:C04131 "KEGG COMPOUND" is_a: CHEBI:23690 ! dicarboxylic acid amide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35740 name: liposaccharide namespace: chebi_ontology synonym: "liposaccharides" RELATED [ChEBI:] is_a: CHEBI:18059 ! lipid is_a: CHEBI:63299 ! carbohydrate derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35741 name: glycerolipid namespace: chebi_ontology def: "Any member of the group of lipids containing a common glycerol backbone to which at least one fatty acyl group is esterified." [] synonym: "glycerolipids" RELATED [ChEBI:] xref: CiteXplore:18606873 "PubMed citation" is_a: CHEBI:18059 ! lipid is_a: CHEBI:33308 ! carboxylic ester property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35742 name: tetracarboxylic acid namespace: chebi_ontology def: "An oxoacid containing four carboxy groups." [] synonym: "C4H4O8R" RELATED FORMULA [ChEBI:] synonym: "tetracarboxylic acids" RELATED [ChEBI:] is_a: CHEBI:33575 ! carboxylic acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35748 name: fatty acid ester namespace: chebi_ontology alt_id: CHEBI:27315 alt_id: CHEBI:35747 alt_id: CHEBI:78205 def: "A carboxylic ester in which the carboxylic acid component can be any fatty acid." [] synonym: "[*]OC([*])=O" RELATED SMILES [ChEBI:] synonym: "CO2R2" RELATED FORMULA [ChEBI:] synonym: "FAEE" RELATED [SUBMITTER:] synonym: "fatty acid esters" RELATED [ChEBI:] synonym: "wax esters" RELATED [ChEBI:] xref: ChEBI:C01629 "KEGG COMPOUND" is_a: CHEBI:18059 ! lipid is_a: CHEBI:33308 ! carboxylic ester property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35757 name: monocarboxylic acid anion namespace: chebi_ontology alt_id: CHEBI:13657 alt_id: CHEBI:25382 alt_id: CHEBI:3407 def: "A carboxylic acid anion formed when the carboxy group of a monocarboxylic acid is deprotonated." [] synonym: "[O-]C([*])=O" RELATED SMILES [ChEBI:] synonym: "a monocarboxylate" RELATED [UniProt:] synonym: "Carboxylate" RELATED [KEGG COMPOUND:] synonym: "CO2R" RELATED FORMULA [ChEBI:] synonym: "Monocarboxylate" RELATED [KEGG COMPOUND:] synonym: "monocarboxylates" RELATED [ChEBI:] synonym: "monocarboxylic acid anions" RELATED [ChEBI:] xref: KEGG COMPOUND:C00060 "KEGG COMPOUND" is_a: CHEBI:29067 ! carboxylic acid anion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35766 name: glycerophosphoserine namespace: chebi_ontology synonym: "Glycerophosphoserine" EXACT [UniProt:] synonym: "glycerophosphoserines" RELATED [ChEBI:] is_a: CHEBI:26649 ! serine derivative is_a: CHEBI:37739 ! glycerophospholipid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35776 name: arsenic oxoanion namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "arsenic oxoanion" EXACT [ChEBI:] synonym: "arsenic oxoanions" RELATED [ChEBI:] synonym: "oxoanions of arsenic" RELATED [ChEBI:] is_a: CHEBI:22632 ! arsenic molecular entity is_a: CHEBI:33459 ! pnictogen oxoanion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35785 name: sphingoid namespace: chebi_ontology def: "Sphinganine, its homologs and stereoisomers, and the hydroxy and unsaturated derivatives of these compounds." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "Spd" RELATED [CBN:] synonym: "sphingoid" EXACT [CBN:] synonym: "sphingoid base" RELATED [CBN:] synonym: "sphingoid base" RELATED [UniProt:] synonym: "sphingoid bases" RELATED [LIPID MAPS:] synonym: "sphingoids" RELATED [ChEBI:] xref: LIPID MAPS:LMSP01 "LIPID MAPS class" is_a: CHEBI:26739 ! sphingolipid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35790 name: oxazole namespace: chebi_ontology def: "An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "oxazole" EXACT [ChEBI:] synonym: "oxazoles" RELATED [ChEBI:] is_a: CHEBI:38104 ! oxacycle is_a: CHEBI:68452 ! azole property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35795 name: polyprenylbenzoquinone namespace: chebi_ontology synonym: "polyprenylbenzoquinones" RELATED [ChEBI:] is_a: CHEBI:22729 ! benzoquinones is_a: CHEBI:26255 ! prenylquinone property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35800 name: nitroso compound namespace: chebi_ontology def: "Compounds having the nitroso group, -NO, attached to carbon, or to another element, most commonly nitrogen or oxygen." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "nitroso compounds" RELATED [ChEBI:] is_a: CHEBI:51143 ! nitrogen molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35813 name: sulfoxide namespace: chebi_ontology def: "Compounds having the structure R2S=O (R =/= H)." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "sulfoxide" EXACT [ChEBI:] synonym: "sulfoxides" RELATED [ChEBI:] is_a: CHEBI:33261 ! organosulfur compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35819 name: branched-chain fatty acid namespace: chebi_ontology alt_id: CHEBI:22919 alt_id: CHEBI:3166 def: "Any fatty acid in which the parent hydrocarbon chain has one or more alkyl substituents; a common component in animal and bacterial lipids. The fatty acyl chain is usually saturated and the substituent a methyl group; however, unsaturated BCFAs are found in marine animals, and branches other than methyl are found in microbial lipids." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "BCFA" RELATED [ChEBI:] synonym: "BCFAs" RELATED [ChEBI:] synonym: "Branched chain fatty acid" RELATED [KEGG COMPOUND:] synonym: "branched-chain fatty acids" RELATED [ChEBI:] xref: CiteXplore:18318842 "PubMed citation" xref: KEGG COMPOUND:C05996 "KEGG COMPOUND" is_a: CHEBI:35366 ! fatty acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35843 name: arsine oxides namespace: chebi_ontology def: "H3As=O and its hydrocarbyl derivatives." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "arsine oxides" EXACT IUPAC_NAME [IUPAC:] is_a: CHEBI:22632 ! arsenic molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35868 name: hydroxy monocarboxylic acid namespace: chebi_ontology synonym: "hydroxy acid" RELATED [ChEBI:] synonym: "hydroxy monocarboxylic acids" RELATED [ChEBI:] is_a: CHEBI:24669 ! hydroxy carboxylic acid is_a: CHEBI:25384 ! monocarboxylic acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35875 name: imidazopyrimidine namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "imidazopyrimidines" RELATED [ChEBI:] is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:33833 ! heteroarene is_a: CHEBI:38101 ! organonitrogen heterocyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35881 name: pnictogen hydride namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "pnictogen hydride" EXACT [ChEBI:] synonym: "pnictogen hydrides" RELATED [ChEBI:] is_a: CHEBI:33242 ! inorganic hydride is_a: CHEBI:33302 ! pnictogen molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35915 name: sterol ester namespace: chebi_ontology alt_id: CHEBI:13220 alt_id: CHEBI:15115 alt_id: CHEBI:26770 alt_id: CHEBI:26772 alt_id: CHEBI:9268 alt_id: CHEBI:9269 synonym: "C20H31O2R" RELATED FORMULA [KEGG COMPOUND:] synonym: "Sterol ester" EXACT [KEGG COMPOUND:] synonym: "Steryl ester" RELATED [KEGG COMPOUND:] synonym: "steryl ester" RELATED [UniProt:] xref: KEGG COMPOUND:C01958 "KEGG COMPOUND" is_a: CHEBI:33308 ! carboxylic ester is_a: CHEBI:47880 ! steroid ester property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35923 name: hydroperoxide namespace: chebi_ontology def: "A monosubstitution product of hydrogen peroxide, HOOH." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "hydroperoxide" EXACT [ChEBI:] synonym: "hydroperoxides" RELATED [ChEBI:] is_a: CHEBI:24651 ! hydroxides property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35924 name: peroxol namespace: chebi_ontology def: "Monosubstitution products of hydrogen peroxide HOOH, having the skeleton ROOH, in which R is any organyl group." [] synonym: "an hydroperoxide" RELATED [UniProt:] synonym: "HO2R" RELATED FORMULA [ChEBI:] synonym: "hydroperoxides" RELATED [IUPAC:] synonym: "OO[*]" RELATED SMILES [ChEBI:] synonym: "organic hydroperoxides" RELATED [ChEBI:] synonym: "peroxols" EXACT IUPAC_NAME [IUPAC:] synonym: "peroxols" RELATED [ChEBI:] is_a: CHEBI:35923 ! hydroperoxide is_a: CHEBI:36963 ! organooxygen compound is_a: CHEBI:37863 ! chalcoperoxol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35987 name: diamino acid namespace: chebi_ontology def: "Any amino acid carrying two amino groups." [] synonym: "diamino acids" RELATED [ChEBI:] is_a: CHEBI:33709 ! amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:35990 name: bridged compound namespace: chebi_ontology def: "A polycyclic compound in which two rings have two or more atoms in common." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "bridged compounds" RELATED [ChEBI:] is_a: CHEBI:33635 ! polycyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36080 name: protein namespace: chebi_ontology alt_id: CHEBI:13677 alt_id: CHEBI:14911 def: "A biological macromolecule minimally consisting of one polypeptide chain synthesized at the ribosome." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "proteins" EXACT IUPAC_NAME [IUPAC:] is_a: CHEBI:33695 ! information biomacromolecule property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36093 name: inorganic chloride namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "inorganic chloride salt" RELATED [ChEBI:] synonym: "inorganic chloride salts" RELATED [ChEBI:] synonym: "inorganic chlorides" RELATED [ChEBI:] is_a: CHEBI:23114 ! chloride salt is_a: CHEBI:24839 ! inorganic salt property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36094 name: organic chloride salt namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "organic chloride salts" RELATED [ChEBI:] is_a: CHEBI:23114 ! chloride salt is_a: CHEBI:51069 ! organic halide salt property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36132 name: alicyclic ketone namespace: chebi_ontology def: "A cyclic ketone in which the carbocyclic ring structure which may be saturated or unsaturated, but may not be a benzenoid or other aromatic system." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "alicyclic ketone" EXACT [IUPAC:] synonym: "alicyclic ketones" EXACT IUPAC_NAME [IUPAC:] synonym: "alicyclic ketones" RELATED [ChEBI:] is_a: CHEBI:3992 ! cyclic ketone property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36141 name: quinone namespace: chebi_ontology alt_id: CHEBI:13684 alt_id: CHEBI:26517 def: "Compounds having a fully conjugated cyclic dione structure, such as that of benzoquinones, derived from aromatic compounds by conversion of an even number of -CH= groups into -C(=O)- groups with any necessary rearrangement of double bonds (polycyclic and heterocyclic analogues are included)." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "a quinone" RELATED [UniProt:] synonym: "Chinon" RELATED [ChEBI:] synonym: "quinone" EXACT [IUPAC:] synonym: "quinones" EXACT IUPAC_NAME [IUPAC:] synonym: "quinones" RELATED [ChEBI:] xref: Wikipedia:Quinone "Wikipedia" is_a: CHEBI:3992 ! cyclic ketone property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36233 name: disaccharide namespace: chebi_ontology alt_id: CHEBI:23844 alt_id: CHEBI:4654 def: "A compound in which two monosaccharides are joined by a glycosidic bond." [] synonym: "disacarido" RELATED [ChEBI:] synonym: "disacaridos" RELATED [IUPAC:] synonym: "Disaccharid" RELATED [ChEBI:] synonym: "Disaccharide" EXACT [KEGG COMPOUND:] synonym: "disaccharides" EXACT IUPAC_NAME [IUPAC:] synonym: "Disacharid" RELATED [ChEBI:] xref: KEGG COMPOUND:C01911 "KEGG COMPOUND" is_a: CHEBI:50699 ! oligosaccharide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36314 name: glycerophosphoethanolamine namespace: chebi_ontology alt_id: CHEBI:26700 alt_id: CHEBI:35765 synonym: "Glycerophosphoethanolamine" EXACT [UniProt:] synonym: "glycerophosphoethanolamines" RELATED [ChEBI:] synonym: "sn-glycero-3-phosphoethanolamines" RELATED [ChEBI:] is_a: CHEBI:36711 ! phosphoethanolamine is_a: CHEBI:37739 ! glycerophospholipid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36315 name: glycerophosphoinositol namespace: chebi_ontology alt_id: CHEBI:26040 alt_id: CHEBI:35770 def: "Any glycerophospholipid having the polar alcohol inositol esterified to the phosphate group at the sn-3 position of the glycerol backbone." [] synonym: "Glycerophosphoinositol" EXACT [UniProt:] synonym: "glycerophosphoinositols" RELATED [ChEBI:] synonym: "GPI" RELATED [ChEBI:] synonym: "phosphoinositide" RELATED [ChEBI:] synonym: "phosphoinositol" RELATED [ChEBI:] xref: ChEBI:C00626 "KEGG COMPOUND" xref: CiteXplore:14706866 "PubMed citation" is_a: CHEBI:37739 ! glycerophospholipid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36357 name: polyatomic entity namespace: chebi_ontology def: "Any molecular entity consisting of more than one atom." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "polyatomic entities" RELATED [ChEBI:] is_a: CHEBI:23367 ! molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36358 name: polyatomic ion namespace: chebi_ontology def: "An ion consisting of more than one atom." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "polyatomic ions" RELATED [ChEBI:] is_a: CHEBI:24870 ! ion is_a: CHEBI:36357 ! polyatomic entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36359 name: phosphorus oxoacid derivative namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "phosphorus oxoacid derivative" EXACT [ChEBI:] synonym: "phosphorus oxoacid derivatives" RELATED [ChEBI:] is_a: CHEBI:33241 ! oxoacid derivative is_a: CHEBI:36360 ! phosphorus oxoacids and derivatives property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36360 name: phosphorus oxoacids and derivatives namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "phosphorus oxoacids and derivatives" EXACT [ChEBI:] is_a: CHEBI:26082 ! phosphorus molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36468 name: polycyclic ether namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "polycyclic ethers" RELATED [ChEBI:] is_a: CHEBI:37407 ! cyclic ether is_a: CHEBI:38166 ! organic heteropolycyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:3647 name: chlorpromazine namespace: chebi_ontology def: "A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety." [] synonym: "3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine" RELATED [NIST Chemistry WebBook:] synonym: "3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine" EXACT IUPAC_NAME [IUPAC:] synonym: "3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine" RELATED [IUPHAR:] synonym: "Aminazine" RELATED BRAND_NAME [ChemIDplus:] synonym: "C17H19ClN2S" RELATED FORMULA [KEGG COMPOUND:] synonym: "Chlorderazin" RELATED BRAND_NAME [ChemIDplus:] synonym: "Chloropromazine" RELATED BRAND_NAME [IUPHAR:] synonym: "Chlorpromados" RELATED BRAND_NAME [ChemIDplus:] synonym: "Chlorpromazine" EXACT [KEGG COMPOUND:] synonym: "chlorpromazine" RELATED INN [ChemIDplus:] synonym: "chlorpromazinum" RELATED INN [ChemIDplus:] synonym: "clorpromazina" RELATED INN [ChemIDplus:] synonym: "CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc12" RELATED SMILES [ChEBI:] synonym: "Contomin" RELATED BRAND_NAME [ChemIDplus:] synonym: "CPZ" RELATED [ChemIDplus:] synonym: "Cromedazine" RELATED BRAND_NAME [IUPHAR:] synonym: "Esmind" RELATED BRAND_NAME [ChemIDplus:] synonym: "Fenactil" RELATED BRAND_NAME [ChemIDplus:] synonym: "InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3" RELATED InChI [ChEBI:] synonym: "InChIKey=ZPEIMTDSQAKGNT-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "Largactil" RELATED BRAND_NAME [IUPHAR:] synonym: "Megaphen" RELATED BRAND_NAME [IUPHAR:] synonym: "N-(3-dimethylaminopropyl)-3-chlorophenothiazine" RELATED [ChemIDplus:] synonym: "Novomazina" RELATED BRAND_NAME [ChemIDplus:] synonym: "Promactil" RELATED BRAND_NAME [ChemIDplus:] synonym: "Promazil" RELATED BRAND_NAME [ChemIDplus:] synonym: "Sanopron" RELATED BRAND_NAME [ChemIDplus:] synonym: "Thorazine" RELATED BRAND_NAME [IUPHAR:] synonym: "Wintermin" RELATED BRAND_NAME [ChemIDplus:] xref: Beilstein:289793 "Beilstein Registry Number" xref: ChemIDplus:50-53-3 "CAS Registry Number" xref: CiteXplore:1650428 "PubMed citation" xref: CiteXplore:20825390 "PubMed citation" xref: CiteXplore:2427628 "PubMed citation" xref: DrugBank:DB00477 "DrugBank" xref: HMDB:HMDB14620 "HMDB" xref: KEGG COMPOUND:50-53-3 "CAS Registry Number" xref: KEGG COMPOUND:C06906 "KEGG COMPOUND" xref: KEGG DRUG:D00270 "KEGG DRUG" xref: NIST Chemistry WebBook:50-53-3 "CAS Registry Number" xref: Patent:US2645640 "Patent" xref: PDBeChem:Z80 "PDBeChem" xref: Reaxys:289793 "Reaxys Registry Number" xref: Wikipedia:Chlorpromazine "Wikipedia" is_a: CHEBI:32876 ! tertiary amine is_a: CHEBI:36683 ! organochlorine compound is_a: CHEBI:38093 ! phenothiazines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36586 name: carbonyl compound namespace: chebi_ontology def: "Any compound containing the carbonyl group, C=O. The term is commonly used in the restricted sense of aldehydes and ketones, although it actually includes carboxylic acids and derivatives." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "carbonyl compounds" EXACT IUPAC_NAME [IUPAC:] is_a: CHEBI:36587 ! organic oxo compound is_a: CHEBI:36963 ! organooxygen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36587 name: organic oxo compound namespace: chebi_ontology def: "Organic compounds containing an oxygen atom, =O, doubly bonded to carbon or another element." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "organic oxo compounds" RELATED [ChEBI:] synonym: "oxo compounds" EXACT IUPAC_NAME [IUPAC:] is_a: CHEBI:72695 ! organic molecule property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36615 name: triterpenoid namespace: chebi_ontology alt_id: CHEBI:27151 alt_id: CHEBI:9748 def: "Any terpenoid derived from a triterpene. The term includes compounds in which the C30 skeleton of the parent triterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups)." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "Triterpenoid" EXACT [KEGG COMPOUND:] synonym: "triterpenoides" RELATED [ChEBI:] synonym: "triterpenoids" RELATED [ChEBI:] xref: KEGG COMPOUND:C06085 "KEGG COMPOUND" is_a: CHEBI:26873 ! terpenoid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36683 name: organochlorine compound namespace: chebi_ontology def: "An organochlorine compound is a compound containing at least one carbon-chlorine bond." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "chloroorganic compounds" RELATED [ChEBI:] synonym: "chlororganische Verbindungen" RELATED [ChEBI:] synonym: "organochlorine compound" EXACT [ChEBI:] synonym: "organochlorine compounds" RELATED [ChEBI:] is_a: CHEBI:23117 ! chlorine molecular entity is_a: CHEBI:36684 ! organohalogen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36684 name: organohalogen compound namespace: chebi_ontology def: "A compound containing at least one carbon-halogen bond." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "organohalogen compounds" RELATED [ChEBI:] is_a: CHEBI:33285 ! heteroorganic entity is_a: CHEBI:37578 ! halide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36688 name: heterotricyclic compound namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "heterotricyclic compound" EXACT [ChEBI:] synonym: "heterotricyclic compounds" EXACT IUPAC_NAME [IUPAC:] synonym: "heterotricyclic compounds" RELATED [ChEBI:] is_a: CHEBI:33671 ! heteropolycyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36711 name: phosphoethanolamine namespace: chebi_ontology synonym: "phosphoethanolamines" RELATED [ChEBI:] is_a: CHEBI:25703 ! organic phosphate is_a: CHEBI:37734 ! phosphoric ester property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36785 name: carbobicyclic compound namespace: chebi_ontology def: "A bicyclic compound in which all the ring atoms are carbon." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "carbobicyclic compounds" RELATED [ChEBI:] is_a: CHEBI:33636 ! bicyclic compound is_a: CHEBI:35294 ! carbopolycyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36807 name: hydrochloride namespace: chebi_ontology def: "A salt formally resulting from the reaction of hydrochloric acid with an organic base." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "Hydrochlorid" RELATED [ChEBI:] synonym: "hydrochloride salts" RELATED [ChEBI:] synonym: "hydrochlorides" RELATED [ChEBI:] is_a: CHEBI:36094 ! organic chloride salt property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36820 name: ring assembly namespace: chebi_ontology def: "Two or more cyclic systems (single rings or fused systems) which are directly joined to each other by double or single bonds are named ring assemblies when the number of such direct ring junctions is one less than the number of cyclic systems involved." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "ring assemblies" EXACT IUPAC_NAME [IUPAC:] synonym: "ring assembly" EXACT IUPAC_NAME [IUPAC:] is_a: CHEBI:33595 ! cyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36834 name: 3-hydroxy steroid namespace: chebi_ontology def: "Any hydroxy steroid carrying a hydroxy group at position 3." [] synonym: "3-hydroxy steroids" RELATED [ChEBI:] is_a: CHEBI:35350 ! hydroxy steroid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36836 name: 3beta-hydroxy steroid namespace: chebi_ontology alt_id: CHEBI:71195 def: "A 3-hydroxy steroid in which the 3-hydroxy substituent is in the beta-position." [] synonym: "3beta-hydroxy steroids" RELATED [ChEBI:] synonym: "a 3beta-hydroxysteroid" RELATED [UniProt:] xref: SUBMITTER:10535978 "PubMed citation" xref: SUBMITTER:12829805 "PubMed citation" is_a: CHEBI:36834 ! 3-hydroxy steroid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36871 name: inorganic radical namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "inorganic radicals" RELATED [ChEBI:] is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:26519 ! radical property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36873 name: radical anion namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "anion radical" RELATED [IUPAC:] synonym: "radical anion" EXACT IUPAC_NAME [IUPAC:] synonym: "radical anions" RELATED [ChEBI:] is_a: CHEBI:22563 ! anion is_a: CHEBI:36875 ! radical ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36875 name: radical ion namespace: chebi_ontology def: "A radical that carries an electric charge." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "ion radical" RELATED [IUPAC:] synonym: "radical ion" EXACT IUPAC_NAME [IUPAC:] synonym: "radical ions" RELATED [IUPAC:] is_a: CHEBI:24870 ! ion is_a: CHEBI:26519 ! radical property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36876 name: inorganic radical anion namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "inorganic anion radical" RELATED [ChEBI:] synonym: "inorganic radical anions" RELATED [ChEBI:] is_a: CHEBI:36873 ! radical anion is_a: CHEBI:36878 ! inorganic radical ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36878 name: inorganic radical ion namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "inorganic ion radical" RELATED [ChEBI:] synonym: "inorganic radical ions" RELATED [ChEBI:] is_a: CHEBI:36871 ! inorganic radical is_a: CHEBI:36875 ! radical ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36914 name: inorganic ion namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "inorganic ions" RELATED [ChEBI:] is_a: CHEBI:24835 ! inorganic molecular entity is_a: CHEBI:24870 ! ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36915 name: inorganic cation namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "inorganic cations" RELATED [ChEBI:] is_a: CHEBI:36914 ! inorganic ion is_a: CHEBI:36916 ! cation property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36916 name: cation namespace: chebi_ontology alt_id: CHEBI:23058 alt_id: CHEBI:3473 def: "A monoatomic or polyatomic species having one or more elementary charges of the proton." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "Cation" EXACT [KEGG COMPOUND:] synonym: "cation" EXACT [ChEBI:] synonym: "cation" EXACT IUPAC_NAME [IUPAC:] synonym: "cationes" RELATED [ChEBI:] synonym: "cations" RELATED [ChEBI:] synonym: "Kation" RELATED [ChEBI:] synonym: "Kationen" RELATED [ChEBI:] xref: KEGG COMPOUND:C01373 "KEGG COMPOUND" is_a: CHEBI:24870 ! ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36962 name: organochalcogen compound namespace: chebi_ontology def: "An organochalcogen compound is a compound containing at least one carbon-chalcogen bond." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "organochalcogen compound" EXACT [ChEBI:] synonym: "organochalcogen compounds" RELATED [ChEBI:] is_a: CHEBI:33285 ! heteroorganic entity is_a: CHEBI:33304 ! chalcogen molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36963 name: organooxygen compound namespace: chebi_ontology def: "An organochalcogen compound containing at least one carbon-oxygen bond." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "organooxygen compound" EXACT [ChEBI:] synonym: "organooxygen compounds" RELATED [ChEBI:] xref: CiteXplore:17586126 "PubMed citation" is_a: CHEBI:25806 ! oxygen molecular entity is_a: CHEBI:36962 ! organochalcogen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36970 name: vitamin B6 phosphate namespace: chebi_ontology synonym: "vitamin B-6 phosphates" RELATED [JCBN:] synonym: "vitamin B6 phosphates" RELATED [ChEBI:] is_a: CHEBI:25703 ! organic phosphate is_a: CHEBI:37734 ! phosphoric ester property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36976 name: nucleotide namespace: chebi_ontology alt_id: CHEBI:13215 alt_id: CHEBI:13663 alt_id: CHEBI:7656 def: "A nucleotide is a nucleoside phosphate. It is a phosphate ester that has a nucleoside moiety and has at least one phosphate moiety attached to the C-5 carbon of the ribose or deoxyribose moiety." [] synonym: "a nucleotide" RELATED [UniProt:] synonym: "Nucleotide" EXACT [KEGG COMPOUND:] synonym: "nucleotides" RELATED [ChEBI:] xref: KEGG COMPOUND:C00215 "KEGG COMPOUND" is_a: CHEBI:25608 ! nucleoside phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36982 name: cyclic purine nucleotide namespace: chebi_ontology synonym: "cyclic purine nucleotides" RELATED [ChEBI:] is_a: CHEBI:23447 ! cyclic nucleotide is_a: CHEBI:26395 ! purine nucleotide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:36987 name: 3'-deoxyribonucleoside namespace: chebi_ontology synonym: "3'-deoxyribonucleosides" RELATED [ChEBI:] is_a: CHEBI:23636 ! deoxyribonucleoside is_a: CHEBI:47018 ! monohydroxytetrahydrofuran property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37010 name: ribonucleoside 5'-monophosphate namespace: chebi_ontology alt_id: CHEBI:1976 alt_id: CHEBI:1977 alt_id: CHEBI:20500 alt_id: CHEBI:36996 synonym: "5'-Phosphomononucleotide" RELATED [KEGG COMPOUND:] synonym: "5'-Phosphomononucleotides" RELATED [KEGG COMPOUND:] synonym: "5'-ribonucleotides" RELATED [ChEBI:] synonym: "C5H10O7PR" RELATED FORMULA [KEGG COMPOUND:] synonym: "ribonucleoside 5'-monophosphates" RELATED [ChEBI:] xref: KEGG COMPOUND:C00171 "KEGG COMPOUND" xref: KEGG COMPOUND:C01150 "KEGG COMPOUND" is_a: CHEBI:26558 ! ribonucleoside monophosphate is_a: CHEBI:37015 ! ribonucleoside 5'-phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37015 name: ribonucleoside 5'-phosphate namespace: chebi_ontology synonym: "ribonucleoside 5'-phosphates" RELATED [ChEBI:] is_a: CHEBI:16701 ! nucleoside 5'-phosphate is_a: CHEBI:26561 ! ribonucleotide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37016 name: 2'-deoxyribonucleoside 5'-phosphate namespace: chebi_ontology synonym: "2'-deoxyribonucleoside 5'-phosphates" RELATED [ChEBI:] is_a: CHEBI:16701 ! nucleoside 5'-phosphate is_a: CHEBI:19260 ! 2'-deoxyribonucleotide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37022 name: amino-acid anion namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "amino acid anions" RELATED [ChEBI:] synonym: "amino-acid anion" EXACT [ChEBI:] synonym: "amino-acid anions" RELATED [ChEBI:] is_a: CHEBI:29067 ! carboxylic acid anion is_a: CHEBI:35352 ! organonitrogen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37037 name: pyrimidine 2'-deoxyribonucleoside 5'-diphosphate namespace: chebi_ontology synonym: "pyrimidine 2'-deoxyribonucleoside 5'-diphosphates" RELATED [ChEBI:] is_a: CHEBI:16350 ! 2'-deoxyribonucleoside 5'-diphosphate is_a: CHEBI:26433 ! pyrimidine 2'-deoxyribonucleoside diphosphate is_a: CHEBI:26436 ! pyrimidine 2'-deoxyribonucleotide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37042 name: purine 2'-deoxyribonucleoside 5'-triphosphate namespace: chebi_ontology synonym: "purine 2'-deoxyribonucleoside 5'-triphosphates" RELATED [ChEBI:] is_a: CHEBI:16381 ! 2'-deoxyribonucleoside 5'-triphosphate is_a: CHEBI:26389 ! purine deoxyribonucleoside triphosphate is_a: CHEBI:26390 ! purine 2'-deoxyribonucleotide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37043 name: pyrimidine 2'-deoxyribonucleoside 5'-triphosphate namespace: chebi_ontology synonym: "pyrimidine 2'-deoxyribonucleoside 5'-triphosphates" RELATED [ChEBI:] is_a: CHEBI:16381 ! 2'-deoxyribonucleoside 5'-triphosphate is_a: CHEBI:26435 ! pyrimidine deoxyribonucleoside triphosphate is_a: CHEBI:26436 ! pyrimidine 2'-deoxyribonucleotide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37092 name: 2'-deoxycytidine phosphate namespace: chebi_ontology synonym: "2'-deoxycytidine phosphates" RELATED [ChEBI:] is_a: CHEBI:23621 ! deoxycytidine phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37142 name: organoiodine compound namespace: chebi_ontology def: "An organoiodine compound is a compound containing at least one carbon-iodine bond." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "organoiodine compound" EXACT [ChEBI:] synonym: "organoiodine compounds" RELATED [ChEBI:] is_a: CHEBI:24860 ! iodine molecular entity is_a: CHEBI:36684 ! organohalogen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37143 name: organofluorine compound namespace: chebi_ontology def: "An organofluorine compound is a compound containing at least one carbon-fluorine bond." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "fluoroorganic compound" RELATED [ChEBI:] synonym: "fluoroorganic compounds" RELATED [ChEBI:] synonym: "fluoroorganics" RELATED [ChEBI:] synonym: "fluororganische Verbindungen" RELATED [ChEBI:] synonym: "organofluorine compound" EXACT [ChEBI:] synonym: "organofluorine compounds" RELATED [ChEBI:] is_a: CHEBI:24062 ! fluorine molecular entity is_a: CHEBI:36684 ! organohalogen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37163 name: glucan namespace: chebi_ontology alt_id: CHEBI:24255 alt_id: CHEBI:5392 def: "A polysaccharide composed of glucose residues." [] synonym: "C12H22O11(C6H10O5)n" RELATED FORMULA [KEGG COMPOUND:] synonym: "Glucan" EXACT [KEGG COMPOUND:] synonym: "glucan" EXACT IUPAC_NAME [IUPAC:] synonym: "glucans" RELATED [ChEBI:] xref: ChemIDplus:9037-91-6 "CAS Registry Number" xref: KEGG COMPOUND:C01379 "KEGG COMPOUND" is_a: CHEBI:37164 ! homopolysaccharide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37164 name: homopolysaccharide namespace: chebi_ontology def: "Glycans composed of a single type of monosaccharide residue. They are named by replacing the ending '-ose' of the sugar by '-an'." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "homoglycan" RELATED [IUPAC:] synonym: "homopolysaccharide" EXACT IUPAC_NAME [IUPAC:] synonym: "homopolysaccharides" RELATED [ChEBI:] is_a: CHEBI:18154 ! polysaccharide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37175 name: organic hydride namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "organic hydrides" RELATED [ChEBI:] is_a: CHEBI:33692 ! hydrides property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37176 name: mononuclear parent hydride namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "mononuclear hydride" RELATED [ChEBI:] synonym: "mononuclear hydrides" RELATED [IUPAC:] synonym: "mononuclear parent hydrides" EXACT IUPAC_NAME [IUPAC:] is_a: CHEBI:33692 ! hydrides property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37193 name: elemental lead namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] is_a: CHEBI:33585 ! lead molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37237 name: elemental molybdenum namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] is_a: CHEBI:25370 ! molybdenum molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37239 name: molybdenum cation namespace: chebi_ontology synonym: "Mo" RELATED FORMULA [ChEBI:] synonym: "Mo cation" RELATED [UniProt:] synonym: "molybdenum cation" EXACT IUPAC_NAME [IUPAC:] synonym: "molybdenum cations" RELATED [ChEBI:] is_a: CHEBI:33515 ! transition element cation is_a: CHEBI:37237 ! elemental molybdenum property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37247 name: elemental potassium namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] is_a: CHEBI:26217 ! potassium molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37253 name: elemental zinc namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] is_a: CHEBI:27364 ! zinc molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37404 name: elemental copper namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] is_a: CHEBI:23377 ! copper molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37407 name: cyclic ether namespace: chebi_ontology alt_id: CHEBI:37406 def: "Any ether in which the oxygen atom forms part of a ring." [] synonym: "cyclic ether" EXACT [IUPAC:] synonym: "cyclic ethers" EXACT IUPAC_NAME [IUPAC:] synonym: "cyclic ethers" RELATED [ChEBI:] synonym: "epoxy compounds" EXACT IUPAC_NAME [IUPAC:] synonym: "epoxy compounds" RELATED [ChEBI:] is_a: CHEBI:25698 ! ether is_a: CHEBI:38104 ! oxacycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37530 name: phosphatidylinositol 4-phosphate namespace: chebi_ontology alt_id: CHEBI:26035 alt_id: CHEBI:8134 def: "A phosphatidylinositol monophosphate carrying the phosphate group at the 4-position." [] synonym: "C11H18O16P2R2" RELATED FORMULA [KEGG COMPOUND:] synonym: "Phosphatidylinositol 4-phosphate" EXACT [KEGG COMPOUND:] synonym: "phosphatidylinositol 4-phosphates" RELATED [ChEBI:] synonym: "PI(4)P" RELATED [ChEBI:] synonym: "PtdIns4P" RELATED [ChEBI:] xref: CiteXplore:16341241 "PubMed citation" xref: CiteXplore:18785997 "PubMed citation" is_a: CHEBI:26036 ! phosphatidylinositol monophosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37531 name: polyprenol diphosphate namespace: chebi_ontology alt_id: CHEBI:26200 alt_id: CHEBI:8307 alt_id: CHEBI:8318 synonym: "C5H12O7P2(C5H8)n" RELATED FORMULA [KEGG COMPOUND:] synonym: "Polyisopentenyldiphosphate" RELATED [KEGG COMPOUND:] synonym: "Polyisopentenylpyrophosphate" RELATED [KEGG COMPOUND:] synonym: "polyprenol diphosphates" RELATED [ChEBI:] synonym: "Polyprenyl diphosphate" RELATED [KEGG COMPOUND:] xref: ChEBI:LMPR0102010001 "LIPID MAPS instance" xref: KEGG COMPOUND:C05806 "KEGG COMPOUND" xref: KEGG COMPOUND:C05847 "KEGG COMPOUND" is_a: CHEBI:16460 ! polyprenol phosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37533 name: azo compound namespace: chebi_ontology def: "Derivatives of diazene with the general structure R-N=N-R'." [] synonym: "azo compounds" EXACT IUPAC_NAME [IUPAC:] synonym: "azo compounds" RELATED [ChEBI:] is_a: CHEBI:51143 ! nitrogen molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37577 name: heteroatomic molecular entity namespace: chebi_ontology def: "A molecular entity consisting of two or more chemical elements." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "chemical compound" RELATED [ChEBI:] synonym: "heteroatomic molecular entities" RELATED [ChEBI:] is_a: CHEBI:36357 ! polyatomic entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37578 name: halide namespace: chebi_ontology def: "Any heteroatomic molecular entity that is a chemical compound of halogen with other chemical elements." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "halides" RELATED [ChEBI:] xref: Wikipedia:Halide "Wikipedia" is_a: CHEBI:24471 ! halogen molecular entity is_a: CHEBI:37577 ! heteroatomic molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37581 name: gamma-lactone namespace: chebi_ontology alt_id: CHEBI:13194 alt_id: CHEBI:18937 alt_id: CHEBI:22971 alt_id: CHEBI:541 def: "A lactone having a five-membered lactone ring." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "1,4-Lactone" RELATED [KEGG COMPOUND:] synonym: "1,4-lactones" RELATED [ChEBI:] synonym: "a 1,4-lactone" RELATED [UniProt:] synonym: "butyrolactones" RELATED [ChEBI:] synonym: "gamma-lactona" RELATED [ChEBI:] synonym: "gamma-lactonas" RELATED [ChEBI:] synonym: "gamma-lactones" RELATED [ChEBI:] synonym: "gamma-Laktone" RELATED [ChEBI:] xref: ChEBI:C01770 "KEGG COMPOUND" xref: CiteXplore:18789684 "PubMed citation" is_a: CHEBI:25000 ! lactone property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37622 name: carboxamide namespace: chebi_ontology alt_id: CHEBI:35354 alt_id: CHEBI:35355 def: "An amide of a carboxylic acid, having the structure RC(=O)NR2. The term is used as a suffix in systematic name formation to denote the -C(=O)NH2 group including its carbon atom." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "[*]C(=O)N([*])[*]" RELATED SMILES [ChEBI:] synonym: "carboxamides" EXACT IUPAC_NAME [IUPAC:] synonym: "carboxamides" RELATED [ChEBI:] synonym: "CNOR3" RELATED FORMULA [ChEBI:] synonym: "primary carboxamide" RELATED [ChEBI:] is_a: CHEBI:33256 ! primary amide is_a: CHEBI:35352 ! organonitrogen compound is_a: CHEBI:36963 ! organooxygen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:3764 name: clotrimazole namespace: chebi_ontology def: "A member of the class of imidazoles that is 1H-imidazole in which the hydrogen attached to a nitrogen is replaced by a monochlorotrityl group." [] synonym: "1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole" RELATED [ChemIDplus:] synonym: "1-(alpha-(2-Chlorophenyl)benzhydryl)imidazole" RELATED [NIST Chemistry WebBook:] synonym: "1-(o-Chloro-alpha,alpha-diphenylbenzyl)imidazole" RELATED [NIST Chemistry WebBook:] synonym: "1-(o-Chlorotrityl)imidazole" RELATED [ChemIDplus:] synonym: "1-[(2-chlorophenyl)(diphenyl)methyl]-1H-imidazole" EXACT IUPAC_NAME [IUPAC:] synonym: "C22H17ClN2" RELATED FORMULA [ChEBI:] synonym: "Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1" RELATED SMILES [ChEBI:] synonym: "Clotrimazole" EXACT [KEGG COMPOUND:] synonym: "Clotrimazole" EXACT [KEGG DRUG:] synonym: "InChI=1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H" RELATED InChI [ChEBI:] synonym: "InChIKey=VNFPBHJOKIVQEB-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "Lotrimin (TN)" RELATED [KEGG DRUG:] synonym: "Mycelex (TN)" RELATED [KEGG DRUG:] xref: Beilstein:622318 "Beilstein Registry Number" xref: ChemIDplus:23593-75-1 "CAS Registry Number" xref: CiteXplore:18728240 "PubMed citation" xref: CiteXplore:24892421 "PubMed citation" xref: DrugBank:DB00257 "DrugBank" xref: HMDB:HMDB01922 "HMDB" xref: KEGG COMPOUND:23593-75-1 "CAS Registry Number" xref: KEGG COMPOUND:C06922 "KEGG COMPOUND" xref: KEGG DRUG:D00282 "KEGG DRUG" xref: NIST Chemistry WebBook:23593-75-1 "CAS Registry Number" xref: PDBeChem:CL6 "PDBeChem" xref: Reaxys:622318 "Reaxys Registry Number" xref: Wikipedia:Clotrimazole "Wikipedia" is_a: CHEBI:24780 ! imidazoles is_a: CHEBI:83403 ! monochlorobenzenes property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37668 name: terpene lactone namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "terpene lactones" RELATED [ChEBI:] is_a: CHEBI:25000 ! lactone is_a: CHEBI:26873 ! terpenoid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37670 name: protease inhibitor namespace: chebi_ontology def: "A compound which inhibits or antagonizes the biosynthesis or actions of proteases (endopeptidases)." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "protease inhibitors" RELATED [ChEBI:] xref: Wikipedia:Protease_inhibitor_(biology) "Wikipedia" is_a: CHEBI:60258 ! EC 3.4.* (hydrolases acting on peptide bond) inhibitor property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37671 name: (1->3)-beta-D-glucan namespace: chebi_ontology alt_id: CHEBI:10800 alt_id: CHEBI:10802 alt_id: CHEBI:18922 alt_id: CHEBI:530 alt_id: CHEBI:60750 def: "A beta-D-glucan in which the glucose units are connected by (1->3) linkages." [] synonym: "(1,3-beta-D-Glucosyl)n" RELATED [KEGG COMPOUND:] synonym: "(1,3-beta-D-glucosyl)n" RELATED [IUBMB:] synonym: "(1,3-beta-D-glucosyl)n" RELATED [UniProt:] synonym: "(1,3-beta-D-Glucosyl)n+1" RELATED [KEGG COMPOUND:] synonym: "(1,3-beta-D-Glucosyl)n-1" RELATED [KEGG COMPOUND:] synonym: "(1->3)-beta-D-glucopyranan" EXACT IUPAC_NAME [IUPAC:] synonym: "(C6H10O5)nH2O" RELATED FORMULA [ChEBI:] synonym: "1,3-beta-D-Glucan" RELATED [KEGG COMPOUND:] synonym: "1,3-beta-Glucan" RELATED [KEGG COMPOUND:] synonym: "callose" RELATED [ChEBI:] synonym: "curdlan" RELATED [ChEBI:] synonym: "InChI=1S/C18H32O16/c19-1-4-7(22)10(25)11(26)17(31-4)34-15-9(24)6(3-21)32-18(13(15)28)33-14-8(23)5(2-20)30-16(29)12(14)27/h4-29H,1-3H2/t4-,5-,6-,7-,8-,9-,10+,11-,12-,13-,14+,15+,16-,17+,18+/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=DBTMGCOVALSLOR-AKJQSPAISA-N" RELATED InChIKey [ChEBI:] synonym: "zymosan" RELATED [ChEBI:] xref: KEGG COMPOUND:C00965 "KEGG COMPOUND" xref: KEGG GLYCAN:G10477 "KEGG GLYCAN" is_a: CHEBI:28793 ! beta-D-glucan is_a: CHEBI:72813 ! exopolysaccharide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37697 name: indolocarbazole alkaloid namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "indolocarbazole alkaloids" RELATED [ChEBI:] synonym: "indolocarbazoles" RELATED [ChEBI:] is_a: CHEBI:38958 ! indole alkaloid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37699 name: protein kinase inhibitor namespace: chebi_ontology def: "An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of protein kinases." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "protein kinase inhibitors" RELATED [ChEBI:] is_a: CHEBI:76668 ! EC 2.7.* (P-containing group transferase) inhibitor property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37734 name: phosphoric ester namespace: chebi_ontology alt_id: CHEBI:26019 synonym: "phosphate esters" RELATED [ChEBI:] synonym: "phosphoric esters" RELATED [ChEBI:] is_a: CHEBI:26079 ! phosphoric acid derivative is_a: CHEBI:35701 ! ester property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37739 name: glycerophospholipid namespace: chebi_ontology alt_id: CHEBI:24362 alt_id: CHEBI:5456 def: "Any glycerolipid having a phosphate group ester-linked to a terminal carbon of the glycerol backbone." [] synonym: "C3H8O6PR" RELATED FORMULA [KEGG COMPOUND:] synonym: "Glycerophosphodiester" RELATED [KEGG COMPOUND:] synonym: "Glycerophospholipid" EXACT [UniProt:] synonym: "glycerophospholipids" RELATED [ChEBI:] synonym: "phosphatide" RELATED [ChEBI:] synonym: "phosphatides" RELATED [ChEBI:] synonym: "phosphoglyceride" RELATED [ChEBI:] synonym: "phosphoglycerides" RELATED [ChEBI:] xref: CiteXplore:17393491 "PubMed citation" xref: KEGG COMPOUND:C03120 "KEGG COMPOUND" is_a: CHEBI:16247 ! phospholipid is_a: CHEBI:35741 ! glycerolipid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37749 name: halogen oxide namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "halogen oxide" EXACT [ChEBI:] synonym: "halogen oxides" RELATED [ChEBI:] is_a: CHEBI:24471 ! halogen molecular entity is_a: CHEBI:24836 ! inorganic oxide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37750 name: chlorine oxide namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "chlorine oxides" RELATED [ChEBI:] is_a: CHEBI:37749 ! halogen oxide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37826 name: sulfuric acid derivative namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "sulfuric acid derivative" EXACT [ChEBI:] synonym: "sulfuric acid derivatives" RELATED [ChEBI:] is_a: CHEBI:33424 ! sulfur oxoacid derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37841 name: isoprenoid phosphate namespace: chebi_ontology synonym: "isoprenoid phosphates" RELATED [ChEBI:] is_a: CHEBI:16247 ! phospholipid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37863 name: chalcoperoxol namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "chalcoperoxol" EXACT [ChEBI:] synonym: "chalcoperoxols" RELATED [ChEBI:] synonym: "organic chalcohydroperoxide" RELATED [ChEBI:] is_a: CHEBI:36962 ! organochalcogen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:37948 name: oxaspiro compound namespace: chebi_ontology def: "A spiro compound in which at least one of the cyclic components is an oxygen heterocyle." [] synonym: "oxaspiro compounds" RELATED [ChEBI:] is_a: CHEBI:33599 ! spiro compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38001 name: 2,6-diaminopurine namespace: chebi_ontology synonym: "2,6-diaminopurines" RELATED [ChEBI:] is_a: CHEBI:22527 ! aminopurine property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38093 name: phenothiazines namespace: chebi_ontology is_a: CHEBI:26979 ! organic heterotricyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38101 name: organonitrogen heterocyclic compound namespace: chebi_ontology def: "Any organonitrogen compound containing a cyclic component with nitrogen and at least one other element as ring member atoms." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "heterocyclic organonitrogen compounds" RELATED [ChEBI:] synonym: "organonitrogen heterocyclic compounds" RELATED [ChEBI:] is_a: CHEBI:24532 ! organic heterocyclic compound is_a: CHEBI:35352 ! organonitrogen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38102 name: triazines namespace: chebi_ontology def: "Compounds based on a triazine skeleton." [] synonym: "." RELATED FORMULA [ChEBI:] is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:50893 ! azaarene property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38104 name: oxacycle namespace: chebi_ontology def: "Any organic heterocyclic compound containing at least one ring oxygen atom." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "heterocyclic organooxygen compounds" RELATED [ChEBI:] synonym: "organooxygen heterocyclic compounds" RELATED [ChEBI:] synonym: "oxacycles" RELATED [ChEBI:] xref: CiteXplore:17134300 "PubMed citation" is_a: CHEBI:24532 ! organic heterocyclic compound is_a: CHEBI:36963 ! organooxygen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38106 name: organosulfur heterocyclic compound namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "heterocyclic organosulfur compounds" RELATED [ChEBI:] synonym: "organosulfur heterocyclic compounds" RELATED [ChEBI:] is_a: CHEBI:24532 ! organic heterocyclic compound is_a: CHEBI:33261 ! organosulfur compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38108 name: azetidine-2-carboxylic acid namespace: chebi_ontology def: "An azetidinecarboxylic acid that is azetidine substituted by a carboxy group at position 2. It is a plant non-protein amino acid." [] synonym: "azetidine-2-carboxylic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "C4H7NO2" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C4H7NO2/c6-4(7)3-1-2-5-3/h3,5H,1-2H2,(H,6,7)" RELATED InChI [ChEBI:] synonym: "InChIKey=IADUEWIQBXOCDZ-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "OC(=O)C1CCN1" RELATED SMILES [ChEBI:] xref: Beilstein:108467 "Beilstein Registry Number" xref: Beilstein:80680 "Beilstein Registry Number" xref: CiteXplore:19101705 "PubMed citation" xref: HMDB:HMDB29615 "HMDB" xref: Wikipedia:Azetidine-2-carboxylic_acid "Wikipedia" is_a: CHEBI:33709 ! amino acid is_a: CHEBI:46891 ! azetidinecarboxylic acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38124 name: dialdehyde namespace: chebi_ontology def: "Any aldehyde with two aldehyde groups." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "bialdehyde" RELATED [ChEBI:] synonym: "bialdehydes" RELATED [ChEBI:] synonym: "dialdehydes" RELATED [ChEBI:] is_a: CHEBI:17478 ! aldehyde property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38131 name: lactol namespace: chebi_ontology def: "Cyclic hemiacetals formed by intramolecular addition of a hydroxy group to an aldehydic or ketonic carbonyl group. They are thus 1-oxacycloalkan-2-ols or unsaturated analogues." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "lactol" EXACT [IUPAC:] synonym: "lactols" EXACT IUPAC_NAME [IUPAC:] synonym: "lactols" RELATED [ChEBI:] is_a: CHEBI:5653 ! hemiacetal property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38163 name: organic heterotetracyclic compound namespace: chebi_ontology synonym: "organic heterotetracyclic compounds" RELATED [ChEBI:] is_a: CHEBI:38166 ! organic heteropolycyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38164 name: organic heteropentacyclic compound namespace: chebi_ontology synonym: "organic heteropentacyclic compounds" RELATED [ChEBI:] is_a: CHEBI:38166 ! organic heteropolycyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38165 name: organic heterooctacyclic compound namespace: chebi_ontology synonym: "organic heterooctacyclic compounds" RELATED [ChEBI:] is_a: CHEBI:38166 ! organic heteropolycyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38166 name: organic heteropolycyclic compound namespace: chebi_ontology alt_id: CHEBI:25429 alt_id: CHEBI:38075 synonym: "." RELATED FORMULA [ChEBI:] synonym: "multi-ring heterocyclic compounds" RELATED [ChEBI:] synonym: "organic heteropolycyclic compounds" RELATED [ChEBI:] is_a: CHEBI:24532 ! organic heterocyclic compound is_a: CHEBI:33671 ! heteropolycyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38179 name: monocyclic heteroarene namespace: chebi_ontology synonym: "monocyclic heteroarenes" RELATED [ChEBI:] is_a: CHEBI:33833 ! heteroarene property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38180 name: polycyclic heteroarene namespace: chebi_ontology synonym: "polycyclic heteroarenes" RELATED [ChEBI:] is_a: CHEBI:33833 ! heteroarene property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38182 name: monohydroxypyridine namespace: chebi_ontology def: "A hydroxypyridine carrying a single hydroxy substituent." [] synonym: "monohydroxypyridines" RELATED [ChEBI:] is_a: CHEBI:24745 ! hydroxypyridine property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38187 name: pyridinecarbaldehyde namespace: chebi_ontology synonym: "pyridinecarbaldehydes" RELATED [ChEBI:] is_a: CHEBI:26421 ! pyridines is_a: CHEBI:49104 ! heteroarenecarbaldehyde property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38196 name: hydroxymethylpyridine namespace: chebi_ontology def: "Any member of the class of pyridines carrying a hydroxymethyl substituent at unspecified position." [] synonym: "hydroxymethylpyridines" RELATED [ChEBI:] is_a: CHEBI:26421 ! pyridines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38198 name: aminoalkylpyridine namespace: chebi_ontology synonym: "aminoalkylpyridines" RELATED [ChEBI:] is_a: CHEBI:26421 ! pyridines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38260 name: pyrrolidines namespace: chebi_ontology alt_id: CHEBI:26922 alt_id: CHEBI:38191 def: "Any of a class of heterocyclic amines having a saturated five-membered ring." [] synonym: "tetrahydropyrroles" RELATED [ChEBI:] is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38263 name: 2-amino-3-hydroxybutanoic acid namespace: chebi_ontology def: "An alpha-amino acid that is butanoic acid substituted by an amino group at position 2 and a hydroxy group at position 3." [] synonym: "2-amino-3-hydroxybutanoic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "C4H9NO3" RELATED FORMULA [ChEBI:] synonym: "CC(O)C(N)C(O)=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)" RELATED InChI [ChEBI:] synonym: "InChIKey=AYFVYJQAPQTCCC-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] xref: Beilstein:1098902 "Beilstein Registry Number" is_a: CHEBI:33704 ! alpha-amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38264 name: 2-amino-3-methylpentanoic acid namespace: chebi_ontology def: "A branched chain amino acid that consists of 3-methylpentanoic acid bearing an amino substituent at position 2." [] synonym: "2-amino-3-methylpentanoic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "C6H13NO2" RELATED FORMULA [ChEBI:] synonym: "CCC(C)C(N)C(O)=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)" RELATED InChI [ChEBI:] synonym: "InChIKey=AGPKZVBTJJNPAG-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] xref: ChemIDplus:443-79-8 "CAS Registry Number" xref: CiteXplore:10944265 "PubMed citation" xref: KEGG COMPOUND:443-79-8 "CAS Registry Number" xref: KEGG COMPOUND:C16434 "KEGG COMPOUND" xref: Reaxys:1721790 "Reaxys Registry Number" is_a: CHEBI:22918 ! branched-chain amino acid is_a: CHEBI:33704 ! alpha-amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38303 name: azirinopyrroloindole namespace: chebi_ontology synonym: "azirinopyrroloindoles" RELATED [ChEBI:] is_a: CHEBI:38101 ! organonitrogen heterocyclic compound is_a: CHEBI:38163 ! organic heterotetracyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38313 name: diazines namespace: chebi_ontology def: "Any organic heterocyclic compound containing a benzene ring in which two of the C-H fragments have been replaced by isolobal nitrogens (the diazine parent structure)." [] is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38314 name: pyrazines namespace: chebi_ontology is_a: CHEBI:38313 ! diazines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38337 name: pyrimidone namespace: chebi_ontology def: "A pyrimidine carrying one or more oxo substituents." [] synonym: "pyrimidones" RELATED [ChEBI:] is_a: CHEBI:39447 ! pyrimidines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38338 name: aminopyrimidine namespace: chebi_ontology def: "A member of the class of pyrimidines that is pyrimidine substituted by at least one amino group and its derivatives." [] synonym: "aminopyrimidines" RELATED [ChEBI:] is_a: CHEBI:33860 ! aromatic amine is_a: CHEBI:39447 ! pyrimidines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38418 name: 1,3-thiazole namespace: chebi_ontology alt_id: CHEBI:26949 alt_id: CHEBI:38417 synonym: "1,3-thiazoles" RELATED [ChEBI:] synonym: "thiazoles" RELATED [ChEBI:] is_a: CHEBI:48901 ! thiazoles property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38439 name: N-acetyl-D-glucosaminate namespace: chebi_ontology alt_id: CHEBI:12454 alt_id: CHEBI:38438 alt_id: CHEBI:57960 def: "A monocarboxylic acid anion resulting from deprotonation of the carboxy group of N-acetyl-D-glucosaminic acid; major species at pH 7.3." [] synonym: "2-acetamido-2-deoxy-D-gluconate" EXACT IUPAC_NAME [IUPAC:] synonym: "C8H14NO7" RELATED FORMULA [ChEBI:] synonym: "CC(=O)N[C@H]([C@@H](O)[C@H](O)[C@H](O)CO)C([O-])=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C8H15NO7/c1-3(11)9-5(8(15)16)7(14)6(13)4(12)2-10/h4-7,10,12-14H,2H2,1H3,(H,9,11)(H,15,16)/p-1/t4-,5-,6-,7-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=LZKNVSNNPRQZJB-DBRKOABJSA-M" RELATED InChIKey [ChEBI:] synonym: "N-Acetyl-D-glucosaminate" EXACT [KEGG COMPOUND:] synonym: "N-acetyl-D-glucosaminate" EXACT [UniProt:] xref: KEGG COMPOUND:C01133 "KEGG COMPOUND" is_a: CHEBI:35757 ! monocarboxylic acid anion is_a: CHEBI:63551 ! carbohydrate acid derivative anion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38443 name: 1-benzopyran namespace: chebi_ontology synonym: "1-benzopyrans" RELATED [ChEBI:] is_a: CHEBI:22727 ! benzopyran property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38459 name: oxindole namespace: chebi_ontology def: "A compound based on an oxindole skeleton." [] is_a: CHEBI:24829 ! indolones property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38532 name: hydrazone namespace: chebi_ontology def: "Compounds having the structure R2C=NNR2, formally derived from aldehydes or ketones by replacing =O by =NNH2 (or substituted analogues)." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "hydrazones" EXACT IUPAC_NAME [IUPAC:] synonym: "hydrazones" RELATED [ChEBI:] is_a: CHEBI:35352 ! organonitrogen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38579 name: peptide pheromone namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "peptide pheromones" RELATED [ChEBI:] is_a: CHEBI:16670 ! peptide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38582 name: difluorobenzene namespace: chebi_ontology def: "Any member of the class of fluorobenzenes containing a mono- or poly-substituted benzene ring carrying two fluoro atoms." [] synonym: "C6H4F2" RELATED FORMULA [ChEBI:] synonym: "Difluorbenzol" RELATED [ChEBI:] synonym: "difluorobenzene" EXACT IUPAC_NAME [IUPAC:] synonym: "difluorobenzenes" RELATED [ChEBI:] is_a: CHEBI:35496 ! fluorobenzenes property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38631 name: aminoalkylindole namespace: chebi_ontology alt_id: CHEBI:22503 alt_id: CHEBI:24792 synonym: "aminoalkylindoles" RELATED [ChEBI:] synonym: "indolalkylamines" RELATED [ChEBI:] is_a: CHEBI:24828 ! indoles property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38669 name: pyrazolopyrimidine namespace: chebi_ontology synonym: "pyrazolopyrimidines" RELATED [ChEBI:] is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38700 name: organic sodium salt namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "organic sodium salt" EXACT [ChEBI:] synonym: "organic sodium salts" RELATED [ChEBI:] is_a: CHEBI:24868 ! organic salt is_a: CHEBI:26714 ! sodium salt property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38702 name: inorganic sodium salt namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "inorganic sodium salts" RELATED [ChEBI:] is_a: CHEBI:24839 ! inorganic salt is_a: CHEBI:26714 ! sodium salt property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38716 name: carboxylic acid dianion namespace: chebi_ontology def: "Any dianion containing at least one carboxy group." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "carboxylic acid dianion" EXACT [ChEBI:] synonym: "carboxylic acid dianions" RELATED [ChEBI:] is_a: CHEBI:29067 ! carboxylic acid anion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38777 name: azetidines namespace: chebi_ontology is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38785 name: morpholines namespace: chebi_ontology def: "Any compound containing morpholine as part of its structure." [] is_a: CHEBI:46952 ! oxazinane property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38830 name: 1-benzofurans namespace: chebi_ontology def: "A member of the class of benzofurans consisting of a 1-benzofuran skeleton and its substituted derivatives thereof." [] is_a: CHEBI:35259 ! benzofurans property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38831 name: 2-benzofurans namespace: chebi_ontology is_a: CHEBI:35259 ! benzofurans property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38921 name: pyridoquinoline namespace: chebi_ontology synonym: "pyridoquinolines" RELATED [ChEBI:] is_a: CHEBI:26979 ! organic heterotricyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38934 name: purvalanol namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "purvalanols" RELATED [ChEBI:] is_a: CHEBI:38001 ! 2,6-diaminopurine property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:38958 name: indole alkaloid namespace: chebi_ontology alt_id: CHEBI:24795 alt_id: CHEBI:5901 def: "An alkaloid containing an indole skeleton." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "Indole alkaloid" EXACT [KEGG COMPOUND:] synonym: "indole alkaloids" RELATED [ChEBI:] xref: KEGG COMPOUND:C06073 "KEGG COMPOUND" xref: Wikipedia:Indole_alkaloid "Wikipedia" is_a: CHEBI:22315 ! alkaloid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:39123 name: calcium cation namespace: chebi_ontology synonym: "Ca" RELATED FORMULA [ChEBI:] synonym: "calcium cation" EXACT [ChEBI:] synonym: "calcium cations" RELATED [ChEBI:] is_a: CHEBI:33513 ! alkaline earth cation is_a: CHEBI:39124 ! calcium ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:39124 name: calcium ion namespace: chebi_ontology synonym: "Ca" RELATED FORMULA [ChEBI:] synonym: "calcium ion" EXACT [ChEBI:] synonym: "calcium ions" RELATED [ChEBI:] is_a: CHEBI:25213 ! metal cation is_a: CHEBI:35155 ! elemental calcium property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:39127 name: magnesium cation namespace: chebi_ontology synonym: "magnesium cation" EXACT [ChEBI:] synonym: "magnesium cations" RELATED [ChEBI:] synonym: "Mg" RELATED FORMULA [ChEBI:] is_a: CHEBI:33513 ! alkaline earth cation is_a: CHEBI:39128 ! magnesium ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:39128 name: magnesium ion namespace: chebi_ontology synonym: "magnesium ion" EXACT [ChEBI:] synonym: "magnesium ions" RELATED [ChEBI:] synonym: "Mg" RELATED FORMULA [ChEBI:] is_a: CHEBI:33973 ! elemental magnesium property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:39146 name: trichostatin namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "trichostatin" EXACT [ChEBI:] synonym: "trichostatins" RELATED [ChEBI:] is_a: CHEBI:49319 ! carbocyclic antibiotic property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:39410 name: 1,2,4-triazines namespace: chebi_ontology def: "Any compound with a 1,2,4-triazine skeleton, in which nitrogen atoms replace carbon at positions 1, 2 and 4 of the core benzene ring structure." [] xref: CiteXplore:20194696 "PubMed citation" is_a: CHEBI:38102 ! triazines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:39417 name: branched-chain saturated fatty acid namespace: chebi_ontology def: "Any saturated fatty acid with a carbon side-chain or isopropyl termination." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "branched-chain saturated fatty acid" EXACT [ChEBI:] synonym: "branched-chain saturated fatty acids" RELATED [ChEBI:] is_a: CHEBI:26607 ! saturated fatty acid is_a: CHEBI:35819 ! branched-chain fatty acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:39446 name: pyrimidine ribonucleosides namespace: chebi_ontology alt_id: CHEBI:13784 alt_id: CHEBI:26445 alt_id: CHEBI:7263 synonym: "an N-D-ribosylpyrimidine" RELATED [UniProt:] synonym: "C9H13N2O4" RELATED FORMULA [KEGG COMPOUND:] synonym: "N-D-Ribosylpyrimidine" RELATED [KEGG COMPOUND:] synonym: "pyrimidine ribonucleosides" EXACT [ChEBI:] xref: KEGG COMPOUND:C03143 "KEGG COMPOUND" is_a: CHEBI:18254 ! ribonucleoside is_a: CHEBI:26440 ! pyrimidine nucleoside property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:39447 name: pyrimidines namespace: chebi_ontology alt_id: CHEBI:13681 alt_id: CHEBI:26448 def: "Any compound having a pyrimidine as part of its structure." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "a pyrimidine" RELATED [UniProt:] synonym: "pyrimidines" EXACT [ChEBI:] is_a: CHEBI:38313 ! diazines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:39457 name: pyrimidine ribonucleoside 5'-monophosphate namespace: chebi_ontology alt_id: CHEBI:13682 alt_id: CHEBI:37019 alt_id: CHEBI:8677 def: "A pyrimidine ribonucleoside monophosphate that has formula C9H15N2O7P." [] synonym: "C9H15N2O7P" RELATED FORMULA [KEGG COMPOUND:] synonym: "InChI=1S/C9H13N2O7P/c12-7-6(4-17-19(14,15)16)18-9(8(7)13)11-3-1-2-10-5-11/h1-3,5-9,12-13H,4H2,(H-,14,15,16)/p+1/t6-,7-,8-,9-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=HOIOQWNHWWQJPL-FNCVBFRFSA-O" RELATED InChIKey [ChEBI:] synonym: "O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)[n+]1cccnc1" RELATED SMILES [ChEBI:] synonym: "Pyrimidine 5'-nucleotide" RELATED [KEGG COMPOUND:] synonym: "pyrimidine 5'-nucleotide" RELATED [UniProt:] synonym: "pyrimidine ribonucleoside 5'-monophosphates" RELATED [ChEBI:] synonym: "pyrimidine ribonucleoside 5'-phosphate" RELATED [ChEBI:] xref: KEGG COMPOUND:C03536 "KEGG COMPOUND" is_a: CHEBI:26443 ! pyrimidine ribonucleoside monophosphate is_a: CHEBI:26446 ! pyrimidine ribonucleotide is_a: CHEBI:37010 ! ribonucleoside 5'-monophosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:39867 name: valproic acid namespace: chebi_ontology alt_id: CHEBI:115217 alt_id: CHEBI:39858 alt_id: CHEBI:9926 def: "A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem." [] synonym: "2-n-propyl-n-valeric acid" RELATED [NIST Chemistry WebBook:] synonym: "2-PROPYL-PENTANOIC ACID" RELATED [PDBeChem:] synonym: "2-propylpentanoic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "2-propylpentanoic acid" RELATED [ChEMBL:] synonym: "2-propylvaleric acid" RELATED [ChemIDplus:] synonym: "4-heptanecarboxylic acid" RELATED [ChemIDplus:] synonym: "acide valproique" RELATED INN [ChemIDplus:] synonym: "acido valproico" RELATED INN [ChemIDplus:] synonym: "acidum valproicum" RELATED INN [ChemIDplus:] synonym: "C8H16O2" RELATED FORMULA [ChEBI:] synonym: "CCCC(CCC)C(O)=O" RELATED SMILES [ChEBI:] synonym: "Depakene" RELATED BRAND_NAME [KEGG DRUG:] synonym: "di-n-propylacetic acid" RELATED [ChemIDplus:] synonym: "Di-n-propylessigsaeure" RELATED [ChemIDplus:] synonym: "dipropylacetic acid" RELATED [NIST Chemistry WebBook:] synonym: "DPA" RELATED [NIST Chemistry WebBook:] synonym: "InChI=1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)" RELATED InChI [ChEBI:] synonym: "InChIKey=NIJJYAXOARWZEE-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "n-DPA" RELATED [DrugBank:] synonym: "VALPROIC ACID" EXACT [ChEMBL:] synonym: "valproic acid" RELATED INN [ChemIDplus:] synonym: "Valproinsaeure" RELATED [ChEBI:] synonym: "VPA" RELATED [ChEBI:] xref: ChemIDplus:1750447 "Beilstein Registry Number" xref: ChemIDplus:99-66-1 "CAS Registry Number" xref: CiteXplore:11716839 "PubMed citation" xref: CiteXplore:12475192 "PubMed citation" xref: CiteXplore:15124690 "PubMed citation" xref: CiteXplore:15560954 "PubMed citation" xref: CiteXplore:15578701 "PubMed citation" xref: CiteXplore:16496131 "PubMed citation" xref: CiteXplore:16621443 "PubMed citation" xref: CiteXplore:16759735 "PubMed citation" xref: CiteXplore:17156483 "PubMed citation" xref: CiteXplore:17273758 "PubMed citation" xref: CiteXplore:19280426 "PubMed citation" xref: CiteXplore:19318486 "PubMed citation" xref: CiteXplore:23792104 "PubMed citation" xref: CiteXplore:23810771 "PubMed citation" xref: CiteXplore:23949302 "PubMed citation" xref: CiteXplore:24135375 "PubMed citation" xref: CiteXplore:24200999 "PubMed citation" xref: CiteXplore:24348849 "PubMed citation" xref: CiteXplore:8558327 "PubMed citation" xref: CiteXplore:8681902 "PubMed citation" xref: DrugBank:DB00313 "DrugBank" xref: HMDB:HMDB01877 "HMDB" xref: KEGG COMPOUND:C07185 "KEGG COMPOUND" xref: KEGG DRUG:D00399 "KEGG DRUG" xref: LIPID MAPS:LMFA01020291 "LIPID MAPS instance" xref: NIST Chemistry WebBook:99-66-1 "CAS Registry Number" xref: PDBeChem:2PP "PDBeChem" xref: Reaxys:1750447 "Reaxys Registry Number" xref: Wikipedia:Valproic_Acid "Wikipedia" is_a: CHEBI:39417 ! branched-chain saturated fatty acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:3992 name: cyclic ketone namespace: chebi_ontology synonym: "Cyclic ketone" EXACT [KEGG COMPOUND:] synonym: "cyclic ketones" EXACT IUPAC_NAME [IUPAC:] xref: KEGG COMPOUND:C02019 "KEGG COMPOUND" is_a: CHEBI:17087 ! ketone property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:40036 name: amitrole namespace: chebi_ontology alt_id: CHEBI:1448 alt_id: CHEBI:40029 def: "A member of the class of triazoles that is 1H-1,2,4-triazole substituted by an amino group at position 3." [] synonym: "1H-1,2,4-triazol-3-amine" EXACT IUPAC_NAME [IUPAC:] synonym: "1H-1,2,4-triazol-3-ylamine" RELATED [ChemIDplus:] synonym: "2-Amino-1,3,4-triazole" RELATED [KEGG COMPOUND:] synonym: "3-Amino-1,2,4-triazole" RELATED [KEGG COMPOUND:] synonym: "3-amino-s-triazole" RELATED [NIST Chemistry WebBook:] synonym: "3-AT" RELATED [ChemIDplus:] synonym: "Aminotriazole" RELATED [KEGG COMPOUND:] synonym: "Amitrole" EXACT [KEGG COMPOUND:] synonym: "C2H4N4" RELATED FORMULA [KEGG COMPOUND:] synonym: "InChI=1S/C2H4N4/c3-2-4-1-5-6-2/h1H,(H3,3,4,5,6)" RELATED InChI [ChEBI:] synonym: "InChIKey=KLSJWNVTNUYHDU-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "Nc1nc[nH]n1" RELATED SMILES [ChEBI:] xref: Beilstein:107687 "Beilstein Registry Number" xref: ChemIDplus:61-82-5 "CAS Registry Number" xref: CiteXplore:17549540 "PubMed citation" xref: CiteXplore:7986209 "PubMed citation" xref: Gmelin:200706 "Gmelin Registry Number" xref: KEGG COMPOUND:61-82-5 "CAS Registry Number" xref: KEGG COMPOUND:C11261 "KEGG COMPOUND" xref: MetaCyc:CPD0-1491 "MetaCyc" xref: NIST Chemistry WebBook:61-82-5 "CAS Registry Number" xref: Patent:AU2012202062 "Patent" xref: Patent:WO2007147209 "Patent" xref: PDBeChem:3TR "PDBeChem" xref: Reaxys:107687 "Reaxys Registry Number" xref: Wikipedia:Amitrole "Wikipedia" is_a: CHEBI:33860 ! aromatic amine is_a: CHEBI:35727 ! triazoles property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:40303 name: lovastatin namespace: chebi_ontology alt_id: CHEBI:40299 alt_id: CHEBI:6544 def: "A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as a antilipemic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom)." [] synonym: "(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate" RELATED [ChemIDplus:] synonym: "(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate" EXACT IUPAC_NAME [IUPAC:] synonym: "2beta,6alpha-dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactone" RELATED [ChemIDplus:] synonym: "6alpha-methylcompactin" RELATED [ChemIDplus:] synonym: "[H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]1C[C@@H](O)CC(=O)O1)OC(=O)[C@@H](C)CC" RELATED SMILES [ChEBI:] synonym: "C24H36O5" RELATED FORMULA [KEGG COMPOUND:] synonym: "InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=PCZOHLXUXFIOCF-BXMDZJJMSA-N" RELATED InChIKey [ChEBI:] synonym: "LOVASTATIN" EXACT [PDBeChem:] synonym: "Lovastatin" EXACT [KEGG COMPOUND:] synonym: "Mevacor" RELATED BRAND_NAME [ChemIDplus:] synonym: "Mevinolin" RELATED [ChemIDplus:] synonym: "MK-803" RELATED [KEGG DRUG:] synonym: "ML-530B" RELATED [KEGG DRUG:] xref: ChemIDplus:3631989 "Beilstein Registry Number" xref: ChemIDplus:75330-75-5 "CAS Registry Number" xref: CiteXplore:11375168 "PubMed citation" xref: CiteXplore:11389707 "PubMed citation" xref: CiteXplore:11483865 "PubMed citation" xref: CiteXplore:18642339 "PubMed citation" xref: CiteXplore:24093797 "PubMed citation" xref: DrugBank:DB00227 "DrugBank" xref: HMDB:HMDB14372 "HMDB" xref: KEGG COMPOUND:C07074 "KEGG COMPOUND" xref: KEGG DRUG:75330-75-5 "CAS Registry Number" xref: KEGG DRUG:D00359 "KEGG DRUG" xref: KNApSAcK:C00000547 "KNApSAcK" xref: Patent:CN103172602 "Patent" xref: Patent:WO2013090461 "Patent" xref: PDBeChem:803 "PDBeChem" xref: Reaxys:4720754 "Reaxys Registry Number" xref: Wikipedia:Lovastatin "Wikipedia" is_a: CHEBI:18946 ! delta-lactone is_a: CHEBI:26188 ! polyketide is_a: CHEBI:35748 ! fatty acid ester is_a: CHEBI:36785 ! carbobicyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:4031 name: cyclosporin A namespace: chebi_ontology alt_id: CHEBI:63586 def: "A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle." [] synonym: "(R-[R*,R*-(E)])-Cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-alpha-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl)" RELATED [ChEBI:] synonym: "1,11-cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-(E)-(2S,3R,4R)-2-amino-3-hydroxy-N,4-dimethyloct-6-enoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucine]" RELATED [JCBN:] synonym: "30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone" EXACT IUPAC_NAME [IUPAC:] synonym: "30-ethyl-33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone" RELATED [ChEBI:] synonym: "Antibiotic S 7481F1" RELATED [ChemIDplus:] synonym: "C62H111N11O12" RELATED FORMULA [ChEBI:] synonym: "CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\\C=C\\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C" RELATED SMILES [ChEBI:] synonym: "Ciclosporin" RELATED [KEGG COMPOUND:] synonym: "ciclosporin" RELATED INN [KEGG DRUG:] synonym: "ciclosporina" RELATED INN [ChemIDplus:] synonym: "ciclosporine" RELATED INN [ChemIDplus:] synonym: "ciclosporinum" RELATED INN [ChemIDplus:] synonym: "Cyclo(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-((3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl)-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methylleucyl)" RELATED [ChemIDplus:] synonym: "Cyclosporin A" EXACT [KEGG COMPOUND:] synonym: "Cyclosporine" RELATED [KEGG COMPOUND:] synonym: "Cyclosporine" RELATED [ChemIDplus:] synonym: "Gengraf" RELATED BRAND_NAME [DrugBank:] synonym: "InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=PMATZTZNYRCHOR-CGLBZJNRSA-N" RELATED InChIKey [ChEBI:] synonym: "Neoral" RELATED BRAND_NAME [DrugBank:] synonym: "Sandimmune" RELATED BRAND_NAME [DrugBank:] xref: Beilstein:3647785 "Beilstein Registry Number" xref: ChemIDplus:59865-13-3 "CAS Registry Number" xref: CiteXplore:11058832 "PubMed citation" xref: CiteXplore:11069928 "PubMed citation" xref: CiteXplore:11079273 "PubMed citation" xref: CiteXplore:11080188 "PubMed citation" xref: CiteXplore:11238591 "PubMed citation" xref: CiteXplore:11256490 "PubMed citation" xref: CiteXplore:11278005 "PubMed citation" xref: CiteXplore:11315347 "PubMed citation" xref: CiteXplore:11370709 "PubMed citation" xref: CiteXplore:11406057 "PubMed citation" xref: CiteXplore:11426833 "PubMed citation" xref: CiteXplore:11442023 "PubMed citation" xref: CiteXplore:11481617 "PubMed citation" xref: CiteXplore:11493684 "PubMed citation" xref: CiteXplore:11529914 "PubMed citation" xref: CiteXplore:11557554 "PubMed citation" xref: CiteXplore:11564166 "PubMed citation" xref: CiteXplore:11676831 "PubMed citation" xref: CiteXplore:11870366 "PubMed citation" xref: CiteXplore:12021257 "PubMed citation" xref: CiteXplore:12050171 "PubMed citation" xref: CiteXplore:12603598 "PubMed citation" xref: CiteXplore:12761440 "PubMed citation" xref: CiteXplore:12929192 "PubMed citation" xref: CiteXplore:12950728 "PubMed citation" xref: CiteXplore:14521916 "PubMed citation" xref: CiteXplore:14621732 "PubMed citation" xref: CiteXplore:14638917 "PubMed citation" xref: CiteXplore:14672695 "PubMed citation" xref: CiteXplore:14682659 "PubMed citation" xref: CiteXplore:14743390 "PubMed citation" xref: CiteXplore:15030555 "PubMed citation" xref: CiteXplore:15175101 "PubMed citation" xref: CiteXplore:15210365 "PubMed citation" xref: CiteXplore:15306697 "PubMed citation" xref: CiteXplore:15383526 "PubMed citation" xref: CiteXplore:15541012 "PubMed citation" xref: CiteXplore:15613074 "PubMed citation" xref: CiteXplore:15626898 "PubMed citation" xref: CiteXplore:15657176 "PubMed citation" xref: CiteXplore:1566062 "PubMed citation" xref: CiteXplore:15711594 "PubMed citation" xref: CiteXplore:15811524 "PubMed citation" xref: CiteXplore:15962181 "PubMed citation" xref: CiteXplore:16372476 "PubMed citation" xref: CiteXplore:16404634 "PubMed citation" xref: CiteXplore:16724420 "PubMed citation" xref: CiteXplore:16801218 "PubMed citation" xref: CiteXplore:16898534 "PubMed citation" xref: CiteXplore:17032751 "PubMed citation" xref: CiteXplore:17083576 "PubMed citation" xref: CiteXplore:17117422 "PubMed citation" xref: CiteXplore:17192032 "PubMed citation" xref: CiteXplore:17220244 "PubMed citation" xref: CiteXplore:17229932 "PubMed citation" xref: CiteXplore:17265451 "PubMed citation" xref: CiteXplore:17446460 "PubMed citation" xref: CiteXplore:17603747 "PubMed citation" xref: CiteXplore:18076075 "PubMed citation" xref: CiteXplore:18171316 "PubMed citation" xref: CiteXplore:18191430 "PubMed citation" xref: CiteXplore:18217899 "PubMed citation" xref: CiteXplore:18259730 "PubMed citation" xref: CiteXplore:18299432 "PubMed citation" xref: CiteXplore:18359899 "PubMed citation" xref: CiteXplore:18583716 "PubMed citation" xref: CiteXplore:18597363 "PubMed citation" xref: CiteXplore:18790203 "PubMed citation" xref: CiteXplore:18818682 "PubMed citation" xref: CiteXplore:18931077 "PubMed citation" xref: CiteXplore:18975184 "PubMed citation" xref: CiteXplore:19282398 "PubMed citation" xref: CiteXplore:19589783 "PubMed citation" xref: DrugBank:DB00091 "DrugBank" xref: KEGG COMPOUND:59865-13-3 "CAS Registry Number" xref: KEGG COMPOUND:C05086 "KEGG COMPOUND" xref: KEGG DRUG:D00184 "KEGG DRUG" xref: KNApSAcK:C00001517 "KNApSAcK" xref: Patent:US4117118 "Patent" xref: Reaxys:3647785 "Reaxys Registry Number" xref: Wikipedia:Ciclosporin "Wikipedia" is_a: CHEBI:24613 ! homodetic cyclic peptide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:41218 name: mercaptoethanol namespace: chebi_ontology alt_id: CHEBI:41215 alt_id: CHEBI:6766 def: "An alkanethiol that has formula C2H6OS." [] synonym: "2-Mercaptoethanol" RELATED [KEGG COMPOUND:] synonym: "2-sulfanylethanol" EXACT IUPAC_NAME [IUPAC:] synonym: "2-sulfanylethanol" RELATED [PDBeChem:] synonym: "BETA-MERCAPTOETHANOL" RELATED [PDBeChem:] synonym: "beta-mercaptoethanol" RELATED [ChEBI:] synonym: "C2H6OS" RELATED FORMULA [KEGG COMPOUND:] synonym: "InChI=1S/C2H6OS/c3-1-2-4/h3-4H,1-2H2" RELATED InChI [ChEBI:] synonym: "InChIKey=DGVVWUTYPXICAM-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "Mercaptoethanol" EXACT [KEGG COMPOUND:] synonym: "OCCS" RELATED SMILES [ChEBI:] synonym: "Thioglycol" RELATED [KEGG COMPOUND:] xref: Beilstein:773648 "Beilstein Registry Number" xref: ChemIDplus:60-24-2 "CAS Registry Number" xref: DrugBank:DB03345 "DrugBank" xref: Gmelin:1368 "Gmelin Registry Number" xref: KEGG COMPOUND:60-24-2 "CAS Registry Number" xref: KEGG COMPOUND:C00928 "KEGG COMPOUND" xref: NIST Chemistry WebBook:60-24-2 "CAS Registry Number" xref: PDBeChem:BME "PDBeChem" is_a: CHEBI:15734 ! primary alcohol is_a: CHEBI:47908 ! alkanethiol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:41688 name: crystal violet namespace: chebi_ontology alt_id: CHEBI:3933 def: "An organic chloride salt that is the monochloride salt of crystal violet cation. It has been used in creams for the topical treatment of bacterial and fungal infections, being effective against some Gram-positive bacteria (notably Staphylococcus species) and some pathogenic fungi (including Candida species) but use declined following reports of animal carcinogenicity. It has also been used for dying wood, silk, and paper, as well as a histological stain." [] synonym: "(4-{bis[-(dimethylamino)phenyl]methylene}-2,5-cyclohexadien-1-ylidene)dimethylammonium chloride" RELATED [ChemIDplus:] synonym: "4-{bis[4-(dimethylamino)phenyl]methylene}-N,N-dimethylcyclohexa-2,5-dien-1-iminium chloride" EXACT IUPAC_NAME [IUPAC:] synonym: "[Cl-].CN(C)c1ccc(cc1)C(=C1C=CC(C=C1)=[N+](C)C)c1ccc(cc1)N(C)C" RELATED SMILES [ChEBI:] synonym: "Adergon" RELATED BRAND_NAME [ChemIDplus:] synonym: "aniline violet" RELATED [ChemIDplus:] synonym: "Atmonil" RELATED BRAND_NAME [ChemIDplus:] synonym: "Avermin" RELATED BRAND_NAME [ChemIDplus:] synonym: "Axuris" RELATED BRAND_NAME [ChemIDplus:] synonym: "Badil" RELATED BRAND_NAME [ChemIDplus:] synonym: "Basic Violet 3" RELATED [ChemIDplus:] synonym: "Basic Violet BN" RELATED [ChemIDplus:] synonym: "Bismuth Violet" RELATED [ChemIDplus:] synonym: "Blaues pyoktanin" RELATED [ChemIDplus:] synonym: "Brilliant Violet 5B" RELATED [ChemIDplus:] synonym: "C.I. 42555" RELATED [ChemIDplus:] synonym: "C.I. Basic violet 3" RELATED [ChemIDplus:] synonym: "C25H30ClN3" RELATED FORMULA [ChEBI:] synonym: "Calcozine Violet 6BN" RELATED [ChemIDplus:] synonym: "Calcozine Violet C" RELATED [ChemIDplus:] synonym: "chlorure de methylrosanilinium" RELATED INN [WHO MedNet:] synonym: "CI 42555" RELATED [ChemIDplus:] synonym: "CI Basic Violet 3" RELATED [ChemIDplus:] synonym: "cloruro de metilrosanilina" RELATED INN [WHO MedNet:] synonym: "CRYSTAL VIOLET" EXACT [PDBeChem:] synonym: "Crystal violet" EXACT [KEGG COMPOUND:] synonym: "Gentian violet" RELATED [KEGG COMPOUND:] synonym: "Gentianaviolett" RELATED [ChemIDplus:] synonym: "Gentiaverm" RELATED BRAND_NAME [ChEBI:] synonym: "hexamethyl-p-rosaniline chloride" RELATED [ChEBI:] synonym: "hexamethylpararosaniline chloride" RELATED [ChEBI:] synonym: "InChI=1S/C25H30N3.ClH/c1-26(2)22-13-7-19(8-14-22)25(20-9-15-23(16-10-20)27(3)4)21-11-17-24(18-12-21)28(5)6;/h7-18H,1-6H3;1H/q+1;/p-1" RELATED InChI [ChEBI:] synonym: "InChIKey=ZXJXZNDDNMQXFV-UHFFFAOYSA-M" RELATED InChIKey [ChEBI:] synonym: "Meroxyl" RELATED BRAND_NAME [ChemIDplus:] synonym: "Meroxylan" RELATED BRAND_NAME [ChemIDplus:] synonym: "methylrosaniline chloride" RELATED [KEGG DRUG:] synonym: "methylrosanilinii chloridum" RELATED INN [WHO MedNet:] synonym: "Methylrosanilinium chloride" RELATED [KEGG COMPOUND:] synonym: "methylrosanilinium chloride" RELATED INN [WHO MedNet:] synonym: "N-(-4-{bis[4-(dimethylamino)phenyl]methylene}2,5-cyclohexadien-1-ylidene)-N-methyltrimethanaminium chloride" RELATED [ChEBI:] synonym: "N-(4-{bis[4-(dimethylamino)phenyl]methylidene}cyclohexa-2,5-dien-1-ylidene)-N-methylmethanaminium" RELATED [PDBeChem:] synonym: "Pyoktanin" RELATED BRAND_NAME [ChemIDplus:] synonym: "Vianin" RELATED BRAND_NAME [ChemIDplus:] synonym: "Viocid" RELATED BRAND_NAME [ChemIDplus:] xref: ChemIDplus:548-62-9 "CAS Registry Number" xref: CiteXplore:18464526 "PubMed citation" xref: CiteXplore:21095530 "PubMed citation" xref: CiteXplore:21324408 "PubMed citation" xref: CiteXplore:21444708 "PubMed citation" xref: CiteXplore:2272286 "PubMed citation" xref: CiteXplore:22889741 "PubMed citation" xref: CiteXplore:23007862 "PubMed citation" xref: CiteXplore:23465793 "PubMed citation" xref: CiteXplore:23598113 "PubMed citation" xref: CiteXplore:23664476 "PubMed citation" xref: CiteXplore:23724934 "PubMed citation" xref: CiteXplore:24118276 "PubMed citation" xref: CiteXplore:3150994 "PubMed citation" xref: CiteXplore:3151757 "PubMed citation" xref: CiteXplore:434094 "PubMed citation" xref: CiteXplore:6304876 "PubMed citation" xref: CiteXplore:745616 "PubMed citation" xref: DrugBank:DB00406 "DrugBank" xref: HMDB:HMDB14550 "HMDB" xref: KEGG DRUG:D01046 "KEGG DRUG" xref: PDBeChem:CVI "PDBeChem" xref: Reaxys:3580948 "Reaxys Registry Number" xref: Wikipedia:Crystal_violet "Wikipedia" is_a: CHEBI:36094 ! organic chloride salt property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:4194 name: D-hexose namespace: chebi_ontology def: "A hexose that has D-configuration at position 5." [] synonym: "C6H12O6" RELATED FORMULA [ChEBI:] synonym: "D-hexopyranose" EXACT IUPAC_NAME [IUPAC:] synonym: "D-Hexose" EXACT [KEGG COMPOUND:] synonym: "D-hexose" EXACT [UniProt:] synonym: "D-hexoses" RELATED [ChEBI:] xref: KEGG COMPOUND:C00738 "KEGG COMPOUND" is_a: CHEBI:18133 ! hexose property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:42768 name: geneticin namespace: chebi_ontology alt_id: CHEBI:33028 alt_id: CHEBI:42764 def: "An aminoglycoside antibiotic produced by Micromonospora rhodorangea. It blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells." [] synonym: "(1R,2S,3S,4R,6S)-4,6-diamino-3-[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyloxy]-2-hydroxycyclohexyl 2-amino-2,7-dideoxy-D-glycero-alpha-D-gluco-heptopyranoside" EXACT IUPAC_NAME [IUPAC:] synonym: "antibiotic G 418" RELATED [ChemIDplus:] synonym: "C20H40N4O10" RELATED FORMULA [ChEBI:] synonym: "CN[C@@H]1[C@@H](O)[C@H](OC[C@]1(C)O)O[C@H]1[C@H](N)C[C@H](N)[C@@H](O[C@H]2O[C@H](C(C)O)[C@@H](O)[C@H](O)[C@H]2N)[C@@H]1O" RELATED SMILES [ChEBI:] synonym: "G 418" RELATED [ChemIDplus:] synonym: "G418" RELATED [KEGG COMPOUND:] synonym: "GENETICIN" EXACT [PDBeChem:] synonym: "Geneticin" EXACT [KEGG COMPOUND:] synonym: "InChI=1S/C20H40N4O10/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19/h6-19,24-30H,4-5,21-23H2,1-3H3/t6?,7-,8+,9+,10+,11-,12-,13+,14+,15+,16-,17+,18+,19+,20-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=BRZYSWJRSDMWLG-CAXSIQPQSA-N" RELATED InChIKey [ChEBI:] xref: ChemIDplus:1669188 "Beilstein Registry Number" xref: ChemIDplus:49863-47-0 "CAS Registry Number" xref: DrugBank:DB04263 "DrugBank" xref: KEGG COMPOUND:49863-47-0 "CAS Registry Number" xref: KEGG COMPOUND:C17703 "KEGG COMPOUND" xref: PDBeChem:GET "PDBeChem" is_a: CHEBI:22507 ! aminoglycoside antibiotic property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:43616 name: K-252a namespace: chebi_ontology def: "A organic heterooctacyclic compound that is a potent inhibitor of protein kinase C and is isolated from Nocardiopsis sp K-252a" [] synonym: "Antibiotic K 252a" RELATED [ChemIDplus:] synonym: "Antibiotic SF 2370" RELATED [ChemIDplus:] synonym: "C27H21N3O5" RELATED FORMULA [ChEBI:] synonym: "COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=KOZFSFOOLUUIGY-SOLYNIJKSA-N" RELATED InChIKey [ChEBI:] synonym: "K-252A" EXACT [PDBeChem:] synonym: "K252a" RELATED [ChemIDplus:] synonym: "methyl (5S,6R,8R)-6-hydroxy-5-methyl-13-oxo-5,6,7,8,14,15-hexahydro-13H-5,8-epoxy-4b,8a,14-triazadibenzo[b,h]cycloocta[1,2,3,4-jkl]cyclopenta[e]-as-indacene-6-carboxylate" EXACT IUPAC_NAME [IUPAC:] synonym: "SF 2370" RELATED [ChemIDplus:] xref: ChemIDplus:99533-80-9 "CAS Registry Number" xref: CiteXplore:24356881 "PubMed citation" xref: CiteXplore:24406154 "PubMed citation" xref: CiteXplore:24612679 "PubMed citation" xref: CiteXplore:3759657 "PubMed citation" xref: PDBeChem:KSA "PDBeChem" xref: Reaxys:7419675 "Reaxys Registry Number" is_a: CHEBI:35990 ! bridged compound is_a: CHEBI:38165 ! organic heterooctacyclic compound is_a: CHEBI:74222 ! gamma-lactam property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:44185 name: methotrexate namespace: chebi_ontology alt_id: CHEBI:44183 alt_id: CHEBI:6837 def: "A pteridine that has formula C20H22N8O5." [] synonym: "4-amino-10-methylfolic acid" RELATED [ChemIDplus:] synonym: "4-amino-N(10)-methylpteroylglutamic acid" RELATED [NIST Chemistry WebBook:] synonym: "C20H22N8O5" RELATED FORMULA [KEGG COMPOUND:] synonym: "CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O" RELATED SMILES [ChEBI:] synonym: "Emtexate" RELATED BRAND_NAME [DrugBank:] synonym: "InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=FBOZXECLQNJBKD-ZDUSSCGKSA-N" RELATED InChIKey [ChEBI:] synonym: "Ledertrexate" RELATED BRAND_NAME [DrugBank:] synonym: "METHOTREXATE" EXACT [PDBeChem:] synonym: "Methotrexate" EXACT [KEGG COMPOUND:] synonym: "methotrexate" RELATED INN [KEGG DRUG:] synonym: "methotrexatum" RELATED INN [ChemIDplus:] synonym: "metotrexato" RELATED INN [ChemIDplus:] synonym: "MTX" RELATED [ChemIDplus:] synonym: "N-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)-L-glutamic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "N-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)carbonyl]-L-glutamic acid" RELATED [PDBeChem:] synonym: "N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid" RELATED [NIST Chemistry WebBook:] synonym: "Rheumatrex" RELATED BRAND_NAME [DrugBank:] synonym: "Trexall" RELATED BRAND_NAME [DrugBank:] xref: Beilstein:70669 "Beilstein Registry Number" xref: ChemIDplus:59-05-2 "CAS Registry Number" xref: DrugBank:DB00563 "DrugBank" xref: KEGG COMPOUND:59-05-2 "CAS Registry Number" xref: KEGG COMPOUND:C01937 "KEGG COMPOUND" xref: KEGG DRUG:D00142 "KEGG DRUG" xref: NIST Chemistry WebBook:59-05-2 "CAS Registry Number" xref: Patent:US2512572 "Patent" xref: PDBeChem:MTX "PDBeChem" xref: Wikipedia:Methotrexate "Wikipedia" is_a: CHEBI:26373 ! pteridines is_a: CHEBI:29347 ! monocarboxylic acid amide is_a: CHEBI:35692 ! dicarboxylic acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:4431 name: deoxyribonucleotide namespace: chebi_ontology def: "A nucleotide in which the ribose moiety has one or more of its hydroxy groups substituted by hydrogen." [] synonym: "deoxyribonucleotides" RELATED [ChEBI:] synonym: "O[C@H]1C[C@H]([*])O[C@@H]1COP(O)(O)=O" RELATED SMILES [ChEBI:] is_a: CHEBI:23634 ! deoxyaldopentose phosphate is_a: CHEBI:36976 ! nucleotide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:44423 name: hydroxyurea namespace: chebi_ontology alt_id: CHEBI:44420 alt_id: CHEBI:5816 def: "A member of the class of ureas that is urea in which one of the hydrogens is replaced by a hydroxy group. An antineoplastic used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease." [] synonym: "1-hydroxyurea" RELATED [PDBeChem:] synonym: "carbamohydroxamic acid" RELATED [ChemIDplus:] synonym: "carbamohydroximic acid" RELATED [ChemIDplus:] synonym: "carbamoyl oxime" RELATED [ChemIDplus:] synonym: "carbamyl hydroxamate" RELATED [ChemIDplus:] synonym: "CH4N2O2" RELATED FORMULA [KEGG COMPOUND:] synonym: "hidroxicarbamida" RELATED INN [ChemIDplus:] synonym: "hydrea" RELATED [ChemIDplus:] synonym: "Hydroxycarbamid" RELATED [ChEBI:] synonym: "Hydroxycarbamide" RELATED [KEGG COMPOUND:] synonym: "hydroxycarbamide" RELATED INN [WHO MedNet:] synonym: "hydroxycarbamide" RELATED INN [ChemIDplus:] synonym: "hydroxycarbamidum" RELATED INN [ChemIDplus:] synonym: "Hydroxyharnstoff" RELATED [ChEBI:] synonym: "Hydroxyurea" EXACT [KEGG COMPOUND:] synonym: "hydroxyurea" EXACT [UniProt:] synonym: "InChI=1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)" RELATED InChI [ChEBI:] synonym: "InChIKey=VSNHCAURESNICA-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "N-carbamoylhydroxylamine" RELATED [ChemIDplus:] synonym: "N-HYDROXYUREA" RELATED [PDBeChem:] synonym: "N-hydroxyurea" EXACT IUPAC_NAME [IUPAC:] synonym: "NC(=O)NO" RELATED SMILES [ChEBI:] synonym: "oxyurea" RELATED [ChemIDplus:] xref: ChemIDplus:127-07-1 "CAS Registry Number" xref: ChemIDplus:1741548 "Beilstein Registry Number" xref: CiteXplore:11285159 "PubMed citation" xref: CiteXplore:11298103 "PubMed citation" xref: CiteXplore:11364534 "PubMed citation" xref: CiteXplore:11365149 "PubMed citation" xref: CiteXplore:11391710 "PubMed citation" xref: CiteXplore:12107454 "PubMed citation" xref: CiteXplore:14988684 "PubMed citation" xref: CiteXplore:15772364 "PubMed citation" xref: CiteXplore:15994344 "PubMed citation" xref: CiteXplore:16356682 "PubMed citation" xref: CiteXplore:22983419 "PubMed citation" xref: CiteXplore:23318979 "PubMed citation" xref: CiteXplore:23643402 "PubMed citation" xref: CiteXplore:23696560 "PubMed citation" xref: CiteXplore:9271088 "PubMed citation" xref: DrugBank:DB01005 "DrugBank" xref: Gmelin:130423 "Gmelin Registry Number" xref: HMDB:HMDB15140 "HMDB" xref: KEGG COMPOUND:127-07-1 "CAS Registry Number" xref: KEGG COMPOUND:C07044 "KEGG COMPOUND" xref: KEGG DRUG:D00341 "KEGG DRUG" xref: MetaCyc:HYDROXY-UREA "MetaCyc" xref: Patent:US2705727 "Patent" xref: PDBeChem:NHY "PDBeChem" xref: Reaxys:1741548 "Reaxys Registry Number" xref: Wikipedia:Hydroxyurea "Wikipedia" is_a: CHEBI:47857 ! ureas is_a: CHEBI:64708 ! one-carbon compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:44485 name: N-ethylmaleimide namespace: chebi_ontology alt_id: CHEBI:44483 alt_id: CHEBI:7269 def: "A member of the class of maleimides that is the N-ethyl derivative of maleimide." [] synonym: "1-ethyl-1H-pyrrole-2,5-dione" EXACT IUPAC_NAME [IUPAC:] synonym: "1-ethyl-1H-pyrrole-2,5-dione" RELATED [PDBeChem:] synonym: "C6H7NO2" RELATED FORMULA [ChEBI:] synonym: "C6H7NO2" RELATED FORMULA [KEGG COMPOUND:] synonym: "CCN1C(=O)C=CC1=O" RELATED SMILES [ChEBI:] synonym: "Ethylmaleimide" RELATED [ChemIDplus:] synonym: "InChI=1S/C6H7NO2/c1-2-7-5(8)3-4-6(7)9/h3-4H,2H2,1H3" RELATED InChI [ChEBI:] synonym: "InChIKey=HDFGOPSGAURCEO-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "N-ETHYLMALEIMIDE" EXACT [PDBeChem:] synonym: "N-Ethylmaleimide" EXACT [KEGG COMPOUND:] synonym: "N-ethylmaleimide" EXACT [UniProt:] synonym: "NEM" RELATED [NIST Chemistry WebBook:] xref: Beilstein:112448 "Beilstein Registry Number" xref: ChemIDplus:128-53-0 "CAS Registry Number" xref: CiteXplore:12232209 "PubMed citation" xref: CiteXplore:18499511 "PubMed citation" xref: CiteXplore:24211707 "PubMed citation" xref: CiteXplore:6501266 "PubMed citation" xref: DrugBank:DB02967 "DrugBank" xref: Gmelin:405614 "Gmelin Registry Number" xref: KEGG COMPOUND:128-53-0 "CAS Registry Number" xref: KEGG COMPOUND:C02441 "KEGG COMPOUND" xref: MetaCyc:N-ETHYLMALEIMIDE "MetaCyc" xref: NIST Chemistry WebBook:128-53-0 "CAS Registry Number" xref: PDBeChem:NEQ "PDBeChem" xref: Reaxys:112448 "Reaxys Registry Number" xref: Wikipedia:N-Ethylmaleimide "Wikipedia" is_a: CHEBI:55417 ! maleimides property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:44658 name: okadaic acid namespace: chebi_ontology alt_id: CHEBI:44655 alt_id: CHEBI:7733 def: "A polycyclic ether that has formula C44H68O13." [] synonym: "(2R)-2-hydroxy-3-[(2S,5R,6R,8S)-5-hydroxy-8-{(1R,2E)-3-[(2R,4a'R,5R,6'S,8'R,8a'S)-8'-hydroxy-6'-{(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undec-2-yl]butyl}-7'-methylideneoctahydro-3H,3'H-spiro[furan-2,2'-pyrano[3,2-b]pyran]-5-yl]-1-methylprop-2-en-1-yl}-10-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl]-2-methylpropanoic acid" RELATED [PDBeChem:] synonym: "(2R)-2-hydroxy-3-{(2S,5R,6R,8S)-5-hydroxy-8-[(2R,3E)-4-((2R,4a'R,5R,6'S,8'R,8a'S)-8'-hydroxy-6'-{(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undec-2-yl]butyl}-7'-methylideneoctahydro-3H,3'H-spiro[furan-2,2'-pyrano[3,2-b]pyran]-5-yl)but-3-en-2-yl]-10-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl}-2-methylpropanoic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "9,10-Deepithio-9,10-didehydroacanthifolicin" RELATED [ChemIDplus:] synonym: "[H][C@]1(CC[C@@H](O)[C@]2(O1)O[C@@]([H])(CC(C)=C2)[C@H](C)\\C=C\\[C@@]1([H])CC[C@@]2(CC[C@@]3([H])O[C@]([H])([C@@H](O)C[C@H](C)[C@@]4([H])O[C@@]5(CCCCO5)CC[C@H]4C)C(=C)[C@@H](O)[C@]3([H])O2)O1)C[C@@](C)(O)C(O)=O" RELATED SMILES [ChEBI:] synonym: "C44H68O13" RELATED FORMULA [KEGG COMPOUND:] synonym: "InChI=1S/C44H68O13/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51-42/h9-10,23,26-28,30-39,45-47,50H,5,7-8,11-22,24H2,1-4,6H3,(H,48,49)/b10-9+/t26-,27-,28+,30+,31+,32+,33-,34+,35-,36-,37+,38+,39-,41-,42+,43-,44-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=QNDVLZJODHBUFM-WFXQOWMNSA-N" RELATED InChIKey [ChEBI:] synonym: "OKADAIC ACID" EXACT [PDBeChem:] synonym: "Okadaic acid" EXACT [KEGG COMPOUND:] xref: Beilstein:4640246 "Beilstein Registry Number" xref: Beilstein:4900372 "Beilstein Registry Number" xref: Beilstein:5471989 "Beilstein Registry Number" xref: ChemIDplus:78111-17-8 "CAS Registry Number" xref: DrugBank:DB02169 "DrugBank" xref: KEGG COMPOUND:78111-17-8 "CAS Registry Number" xref: KEGG COMPOUND:C01945 "KEGG COMPOUND" xref: PDBeChem:OKA "PDBeChem" is_a: CHEBI:36468 ! polycyclic ether property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:45951 name: trifluoperazine namespace: chebi_ontology alt_id: CHEBI:45949 alt_id: CHEBI:9709 def: "A member of the class of phenothiazines that is phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-(4-methylpiperazin-1-yl)propyl group at the N-10 position." [] synonym: "10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-10H-phenothiazine" RELATED [NIST Chemistry WebBook:] synonym: "10-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPYL]-2-TRIFLUOROMETHYL-10H-PHENOTHIAZINE" RELATED [PDBeChem:] synonym: "10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine" EXACT IUPAC_NAME [IUPAC:] synonym: "10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine" RELATED [PDBeChem:] synonym: "C21H24F3N3S" RELATED FORMULA [KEGG COMPOUND:] synonym: "CN1CCN(CCCN2c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C21H24F3N3S/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24/h2-3,5-8,15H,4,9-14H2,1H3" RELATED InChI [ChEBI:] synonym: "InChIKey=ZEWQUBUPAILYHI-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "trifluoperazina" RELATED INN [ChemIDplus:] synonym: "Trifluoperazine" EXACT [KEGG COMPOUND:] synonym: "trifluoperazine" RELATED INN [ChEBI:] synonym: "trifluoperazine" RELATED INN [KEGG DRUG:] synonym: "trifluoperazinum" RELATED INN [ChemIDplus:] synonym: "trifluoromethyl-10-(3'-(1-methyl-4-piperazinyl)propyl)phenothiazine" RELATED [NIST Chemistry WebBook:] synonym: "trifluoroperazine" RELATED [NIST Chemistry WebBook:] synonym: "trifluperazine" RELATED [ChemIDplus:] xref: Beilstein:57272 "Beilstein Registry Number" xref: ChemIDplus:117-89-5 "CAS Registry Number" xref: CiteXplore:1650428 "PubMed citation" xref: CiteXplore:19747949 "PubMed citation" xref: DrugBank:DB00831 "DrugBank" xref: Gmelin:2415561 "Gmelin Registry Number" xref: HMDB:HMDB14969 "HMDB" xref: KEGG COMPOUND:117-89-5 "CAS Registry Number" xref: KEGG COMPOUND:C07168 "KEGG COMPOUND" xref: KEGG DRUG:D08636 "KEGG DRUG" xref: NIST Chemistry WebBook:117-89-5 "CAS Registry Number" xref: PDBeChem:TFP "PDBeChem" xref: Reaxys:57272 "Reaxys Registry Number" xref: Wikipedia:Trifluoperazine "Wikipedia" is_a: CHEBI:37143 ! organofluorine compound is_a: CHEBI:38093 ! phenothiazines is_a: CHEBI:46920 ! N-methylpiperazine property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:45979 name: thiabendazole namespace: chebi_ontology alt_id: CHEBI:45977 alt_id: CHEBI:9526 def: "A member of the class of benzimidazoles carrying a 1,3-thiazol-4-yl substituent at position 2. A mainly post-harvest fungicide used to control a wide range of diseases including Aspergillus, Botrytis, Cladosporium and Fusarium." [] synonym: "2-(1,3-THIAZOL-4-YL)-1H-BENZIMIDAZOLE" RELATED [PDBeChem:] synonym: "2-(1,3-thiazol-4-yl)-1H-benzimidazole" EXACT IUPAC_NAME [IUPAC:] synonym: "2-(1,3-thiazol-4-yl)benzimidazole" RELATED [Alan Wood's Pesticides:] synonym: "2-(4-thiazolyl)-1H-benzimidazole" RELATED [Alan Wood's Pesticides:] synonym: "2-(thiazol-4-yl)benzimidazole" RELATED [Alan Wood's Pesticides:] synonym: "4-(2-benzimidazolyl)thiazole" RELATED [ChemIDplus:] synonym: "C10H7N3S" RELATED FORMULA [ChEBI:] synonym: "c1nc(cs1)-c1nc2ccccc2[nH]1" RELATED SMILES [ChEBI:] synonym: "Equizole" RELATED BRAND_NAME [ChemIDplus:] synonym: "InChI=1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13)" RELATED InChI [ChEBI:] synonym: "InChIKey=WJCNZQLZVWNLKY-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "Mintezol" RELATED BRAND_NAME [KEGG DRUG:] synonym: "MK 360" RELATED [ChemIDplus:] synonym: "TBZ" RELATED [ChemIDplus:] synonym: "Thiabendazole" EXACT [KEGG COMPOUND:] synonym: "Thibenzole" RELATED BRAND_NAME [ChemIDplus:] synonym: "Tiabendazole" RELATED [KEGG COMPOUND:] xref: Alan Wood's Pesticides:thiabendazole "Pesticides" xref: Beilstein:611403 "Beilstein Registry Number" xref: ChemIDplus:148-79-8 "CAS Registry Number" xref: CiteXplore:11226373 "PubMed citation" xref: CiteXplore:13900465 "PubMed citation" xref: CiteXplore:23790859 "PubMed citation" xref: CiteXplore:9009055 "PubMed citation" xref: DrugBank:DB00730 "DrugBank" xref: HMDB:HMDB14868 "HMDB" xref: KEGG DRUG:D00372 "KEGG DRUG" xref: MetaCyc:THIABENDAZOLE "MetaCyc" xref: NIST Chemistry WebBook:148-79-8 "CAS Registry Number" xref: Patent:US3017415 "Patent" xref: PDBeChem:TMG "PDBeChem" xref: Reaxys:611403 "Reaxys Registry Number" xref: Wikipedia:Thiabendazole "Wikipedia" is_a: CHEBI:22715 ! benzimidazoles is_a: CHEBI:36820 ! ring assembly is_a: CHEBI:38418 ! 1,3-thiazole property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:46024 name: trichostatin A namespace: chebi_ontology alt_id: CHEBI:39145 alt_id: CHEBI:46022 def: "A trichostatin that has formula C17H22N2O3." [] synonym: "(2E,4E,6R)-7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide" RELATED [ChemIDplus:] synonym: "(2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide" EXACT IUPAC_NAME [IUPAC:] synonym: "(2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide" RELATED [PDBeChem:] synonym: "C17H22N2O3" RELATED FORMULA [ChEBI:] synonym: "C[C@@H](C(=O)c1ccc(cc1)N(C)C)\\C=C(C)\\C=C\\C(=O)NO" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=RTKIYFITIVXBLE-QEQCGCAPSA-N" RELATED InChIKey [ChEBI:] synonym: "TRICHOSTATIN A" EXACT [PDBeChem:] synonym: "TSA" RELATED [ChemIDplus:] xref: Beilstein:5291761 "Beilstein Registry Number" xref: ChemIDplus:58880-19-6 "CAS Registry Number" xref: CiteXplore:21504214 "PubMed citation" xref: PDBeChem:TSN "PDBeChem" is_a: CHEBI:24650 ! hydroxamic acid is_a: CHEBI:39146 ! trichostatin property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:46081 name: fluconazole namespace: chebi_ontology alt_id: CHEBI:46079 alt_id: CHEBI:5099 def: "A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It has been shown to exhibit antifungal activity." [] synonym: "2,4-difluoro-alpha,alpha-bis(1H-1,2,4-triazol-1-ylmethyl)benzyl alcohol" RELATED [ChemIDplus:] synonym: "2-(2,4-difluorophenyl)-1,3-bis-(1H-1,2,4-triazol-1-yl)propan-2-ol" EXACT IUPAC_NAME [IUPAC:] synonym: "2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL" RELATED [PDBeChem:] synonym: "Biozole" RELATED BRAND_NAME [ChEBI:] synonym: "C13H12F2N6O" RELATED FORMULA [KEGG DRUG:] synonym: "Diflucan" RELATED BRAND_NAME [ChEBI:] synonym: "Elazor" RELATED [ChemIDplus:] synonym: "fluconazol" RELATED INN [ChemIDplus:] synonym: "fluconazole" RELATED INN [ChemIDplus:] synonym: "fluconazolum" RELATED INN [ChemIDplus:] synonym: "InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2" RELATED InChI [ChEBI:] synonym: "InChIKey=RFHAOTPXVQNOHP-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "OC(Cn1cncn1)(Cn1cncn1)c1ccc(F)cc1F" RELATED SMILES [ChEBI:] synonym: "Triflucan" RELATED BRAND_NAME [ChEBI:] xref: Beilstein:4269710 "Beilstein Registry Number" xref: ChemIDplus:86386-73-4 "CAS Registry Number" xref: CiteXplore:11366931 "PubMed citation" xref: CiteXplore:16822276 "PubMed citation" xref: CiteXplore:23171950 "PubMed citation" xref: CiteXplore:23793863 "PubMed citation" xref: DrugBank:DB00196 "DrugBank" xref: HMDB:HMDB14342 "HMDB" xref: KEGG DRUG:D00322 "KEGG DRUG" xref: Patent:GB2099818 "Patent" xref: Patent:US4404216 "Patent" xref: PDBeChem:TPF "PDBeChem" xref: Reaxys:7311650 "Reaxys Registry Number" xref: Wikipedia:Fluconazole "Wikipedia" is_a: CHEBI:26878 ! tertiary alcohol is_a: CHEBI:35727 ! triazoles is_a: CHEBI:38582 ! difluorobenzene property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:46245 name: coenzyme Q10 namespace: chebi_ontology alt_id: CHEBI:46241 alt_id: CHEBI:9854 def: "A ubiquinone having a side chain of 10 isoprenoid units. In the naturally-occurring isomer, all isoprenyl double bonds are in the E- configuration." [] synonym: "2-((all-E)-3,7,11,15,19,23,27,31,35,39-decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaenyl)-5,6-dimethoxy-3-methyl-p-benzoquinone" RELATED [ChemIDplus:] synonym: "2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaen-1-yl]-5,6-dimethoxy-3-methyl-1,4-benzoquinone" RELATED [ChEBI:] synonym: "2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaen-1-yl]-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione" EXACT IUPAC_NAME [IUPAC:] synonym: "Adelir" RELATED [KEGG DRUG:] synonym: "all-trans-ubiquinone" RELATED [ChEBI:] synonym: "C59H90O4" RELATED FORMULA [KEGG COMPOUND:] synonym: "COC1=C(OC)C(=O)C(C\\C=C(/C)CC\\C=C(/C)CC\\C=C(/C)CC\\C=C(/C)CC\\C=C(/C)CC\\C=C(/C)CC\\C=C(/C)CC\\C=C(/C)CC\\C=C(/C)CCC=C(C)C)=C(C)C1=O" RELATED SMILES [ChEBI:] synonym: "Coenzyme Q10" EXACT [KEGG COMPOUND:] synonym: "coenzyme Q10" EXACT [ChemIDplus:] synonym: "CoQ" RELATED [ChEBI:] synonym: "CoQ10" RELATED [ChEBI:] synonym: "InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+" RELATED InChI [ChEBI:] synonym: "InChIKey=ACTIUHUUMQJHFO-UPTCCGCDSA-N" RELATED InChIKey [ChEBI:] synonym: "Q" RELATED [ChEBI:] synonym: "Q 199" RELATED [ChemIDplus:] synonym: "Q10" RELATED [ChEBI:] synonym: "Ubidecarenone" RELATED [KEGG COMPOUND:] synonym: "ubiquinone" RELATED [ChEBI:] synonym: "ubiquinone 10" RELATED [ChemIDplus:] synonym: "ubiquinone 50" RELATED [ChemIDplus:] synonym: "UBIQUINONE-10" RELATED [PDBeChem:] synonym: "Ubiquinone-10" RELATED [KEGG COMPOUND:] xref: Beilstein:1900141 "Beilstein Registry Number" xref: ChemIDplus:303-98-0 "CAS Registry Number" xref: CiteXplore:13445756 "PubMed citation" xref: CiteXplore:17605305 "PubMed citation" xref: CiteXplore:18787645 "PubMed citation" xref: CiteXplore:18843432 "PubMed citation" xref: CiteXplore:20367194 "PubMed citation" xref: CiteXplore:7599208 "PubMed citation" xref: CiteXplore:7718355 "PubMed citation" xref: HMDB:HMDB01072 "HMDB" xref: KEGG COMPOUND:303-98-0 "CAS Registry Number" xref: KEGG COMPOUND:C11378 "KEGG COMPOUND" xref: KEGG DRUG:D01065 "KEGG DRUG" xref: KNApSAcK:C00002866 "KNApSAcK" xref: LIPID MAPS:LMPR02010001 "LIPID MAPS instance" xref: PDBeChem:U10 "PDBeChem" xref: Reaxys:1900141 "Reaxys Registry Number" xref: Wikipedia:Coenzyme_Q10 "Wikipedia" is_a: CHEBI:16389 ! ubiquinones property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:46345 name: 5-fluorouracil namespace: chebi_ontology alt_id: CHEBI:2054 alt_id: CHEBI:46343 def: "A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth." [] synonym: "5-Fluoracil" RELATED [ChemIDplus:] synonym: "5-fluoropyrimidine-2,4(1H,3H)-dione" EXACT IUPAC_NAME [IUPAC:] synonym: "5-fluoropyrimidine-2,4(1H,3H)-dione" RELATED [PDBeChem:] synonym: "5-Fluoropyrimidine-2,4-dione" RELATED [ChemIDplus:] synonym: "5-FLUOROURACIL" EXACT [PDBeChem:] synonym: "5-Fluorouracil" EXACT [KEGG COMPOUND:] synonym: "5-fluorouracil" EXACT IUPAC_NAME [IUPAC:] synonym: "5-FU" RELATED [KEGG COMPOUND:] synonym: "C4H3FN2O2" RELATED FORMULA [KEGG COMPOUND:] synonym: "Fc1c[nH]c(=O)[nH]c1=O" RELATED SMILES [ChEBI:] synonym: "Fluorouracil" RELATED [KEGG COMPOUND:] synonym: "fluorouracil" RELATED INN [WHO MedNet:] synonym: "fluorouracil" RELATED INN [ChemIDplus:] synonym: "fluorouracilo" RELATED INN [ChemIDplus:] synonym: "fluorouracilum" RELATED INN [ChemIDplus:] synonym: "InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)" RELATED InChI [ChEBI:] synonym: "InChIKey=GHASVSINZRGABV-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] xref: Beilstein:127172 "Beilstein Registry Number" xref: ChEMBL:18834112 "PubMed citation" xref: ChemIDplus:51-21-8 "CAS Registry Number" xref: CiteXplore:11356943 "PubMed citation" xref: CiteXplore:14769231 "PubMed citation" xref: CiteXplore:19023200 "PubMed citation" xref: DrugBank:DB00544 "DrugBank" xref: HMDB:HMDB14684 "HMDB" xref: KEGG COMPOUND:51-21-8 "CAS Registry Number" xref: KEGG COMPOUND:C07649 "KEGG COMPOUND" xref: KEGG DRUG:D00584 "KEGG DRUG" xref: PDBeChem:URF "PDBeChem" xref: Reaxys:127172 "Reaxys Registry Number" xref: Wikipedia:Fluorouracil "Wikipedia" is_a: CHEBI:37143 ! organofluorine compound is_a: CHEBI:67142 ! nucleobase analogue property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:46733 name: oxabicycloalkane namespace: chebi_ontology synonym: "oxabicycloalkanes" RELATED [ChEBI:] is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:38104 ! oxacycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:46761 name: dipeptide namespace: chebi_ontology alt_id: CHEBI:23835 alt_id: CHEBI:4634 def: "Any molecule that contains two amino-acid residues connected by peptide linkages." [] synonym: "C4H6N2O3R2" RELATED FORMULA [KEGG COMPOUND:] synonym: "Dipeptid" RELATED [ChEBI:] synonym: "Dipeptide" EXACT [KEGG COMPOUND:] synonym: "dipeptides" RELATED [ChEBI:] xref: KEGG COMPOUND:C00107 "KEGG COMPOUND" is_a: CHEBI:25676 ! oligopeptide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:46773 name: hydroxypyrrolidine namespace: chebi_ontology synonym: "hydroxypyrrolidines" RELATED [ChEBI:] is_a: CHEBI:38260 ! pyrrolidines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:46777 name: monohydroxypyrrolidine namespace: chebi_ontology synonym: "monohydroxypyrrolidines" RELATED [ChEBI:] is_a: CHEBI:46773 ! hydroxypyrrolidine property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:46812 name: 1,3-oxazoles namespace: chebi_ontology is_a: CHEBI:35790 ! oxazole property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:46844 name: N-acylpiperazine namespace: chebi_ontology synonym: "N-acylpiperazines" RELATED [ChEBI:] is_a: CHEBI:26144 ! piperazines is_a: CHEBI:32988 ! amide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:46845 name: N-alkylpiperazine namespace: chebi_ontology synonym: "N-alkylpiperazines" RELATED [ChEBI:] is_a: CHEBI:26144 ! piperazines is_a: CHEBI:50996 ! tertiary amino compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:46848 name: N-arylpiperazine namespace: chebi_ontology synonym: "N-arylpiperazines" RELATED [ChEBI:] is_a: CHEBI:26144 ! piperazines is_a: CHEBI:33860 ! aromatic amine is_a: CHEBI:50996 ! tertiary amino compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:46891 name: azetidinecarboxylic acid namespace: chebi_ontology def: "A member of the class of azetidines that is azetidine substituted by at least one carboxy group at unspecified position." [] synonym: "azetidinecarboxylic acids" RELATED [ChEBI:] is_a: CHEBI:33575 ! carboxylic acid is_a: CHEBI:38777 ! azetidines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:46895 name: lipopeptide namespace: chebi_ontology def: "A compound consisting of a peptide with attached lipid." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "lipopeptides" RELATED [ChEBI:] synonym: "LP" RELATED [ChEBI:] xref: CiteXplore:19889045 "PubMed citation" xref: CiteXplore:20545290 "PubMed citation" xref: CiteXplore:23131643 "PubMed citation" xref: CiteXplore:23318669 "PubMed citation" xref: Wikipedia:Lipopeptide "Wikipedia" is_a: CHEBI:16670 ! peptide is_a: CHEBI:18059 ! lipid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:46920 name: N-methylpiperazine namespace: chebi_ontology synonym: "N-methylpiperazines" RELATED [ChEBI:] is_a: CHEBI:46845 ! N-alkylpiperazine property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:46942 name: oxanes namespace: chebi_ontology synonym: "tetrahydropyrans" RELATED [ChEBI:] is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38104 ! oxacycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:46952 name: oxazinane namespace: chebi_ontology synonym: "oxazinanes" RELATED [ChEBI:] is_a: CHEBI:25693 ! organic heteromonocyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound is_a: CHEBI:38104 ! oxacycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:47017 name: tetrahydrofuranol namespace: chebi_ontology synonym: "tetrahydrofuranols" RELATED [ChEBI:] is_a: CHEBI:26912 ! oxolanes property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:47018 name: monohydroxytetrahydrofuran namespace: chebi_ontology synonym: "monohydroxytetrahydrofurans" RELATED [ChEBI:] is_a: CHEBI:47017 ! tetrahydrofuranol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:47019 name: dihydroxytetrahydrofuran namespace: chebi_ontology synonym: "dihydroxytetrahydrofurans" RELATED [ChEBI:] is_a: CHEBI:47017 ! tetrahydrofuranol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:474180 name: caspofungin namespace: chebi_ontology alt_id: CHEBI:599509 def: "A semisynthetic cyclic hexapeptide echinocandin antibiotic which exerts its effect by inhibiting the synthesis of 1,3-beta-D-glucan, an integral component of the fungal cell wall." [] synonym: "(4R,5S)-5-((2-aminoethyl)amino)-N(2)-(10,12-dimethyltetradecanoyl)-4-hydroxy-L-ornithyl-L-threonyl-trans-4-hydroxy-L-prolyl-(S)-4-hydroxy-4-(p-hydroxyphenyl)-L-threonyl-threo-3-hydroxy-L-ornithyl-trans-3-hydroxy-L-proline cyclic (6-1)-peptide" RELATED [ChemIDplus:] synonym: "1-[(4R,5S)-5-[(2-aminoethyl)amino]-N(2)-(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-pneumocandin B0" RELATED [ChEBI:] synonym: "[H][C@@]1(C[C@@H](O)[C@@H](NCCN)NC(=O)[C@@H]2[C@@H](O)CCN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@]2([H])C[C@@H](O)CN2C(=O)[C@@H](NC1=O)[C@@H](C)O)[C@H](O)[C@@H](O)c1ccc(O)cc1)[C@H](O)CCN)NC(=O)CCCCCCCCC(C)CC(C)CC" RELATED SMILES [ChEBI:] synonym: "C52H88N10O15" RELATED FORMULA [ChEBI:] synonym: "Caspofungin" EXACT [ChEMBL:] synonym: "caspofungin" RELATED INN [ChemIDplus:] synonym: "InChI=1S/C52H88N10O15/c1-5-28(2)24-29(3)12-10-8-6-7-9-11-13-39(69)56-34-26-38(68)46(55-22-21-54)60-50(75)43-37(67)19-23-61(43)52(77)41(36(66)18-20-53)58-49(74)42(45(71)44(70)31-14-16-32(64)17-15-31)59-48(73)35-25-33(65)27-62(35)51(76)40(30(4)63)57-47(34)72/h14-17,28-30,33-38,40-46,55,63-68,70-71H,5-13,18-27,53-54H2,1-4H3,(H,56,69)(H,57,72)(H,58,74)(H,59,73)(H,60,75)/t28?,29?,30-,33-,34+,35+,36-,37+,38-,40+,41+,42+,43+,44+,45+,46+/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=JYIKNQVWKBUSNH-OGZDCFRISA-N" RELATED InChIKey [ChEBI:] synonym: "N-{(2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-12-[(2-aminoethyl)amino]-20-[(1R)-3-amino-1-hydroxypropyl]-23-[(1S2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,15-trihydroxy-6-[(1R)-1-hydroxyethyl]-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl}-10,12-dimethyltetradecanamide" EXACT IUPAC_NAME [IUPAC:] xref: Beilstein:8471798 "Beilstein Registry Number" xref: ChemIDplus:162808-62-0 "CAS Registry Number" xref: DrugBank:DB00520 "DrugBank" xref: KEGG DRUG:162808-62-0 "CAS Registry Number" xref: KEGG DRUG:D07626 "KEGG DRUG" xref: Patent:US5378804 "Patent" xref: Patent:WO9421677 "Patent" is_a: CHEBI:24613 ! homodetic cyclic peptide is_a: CHEBI:57248 ! echinocandin property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:47600 name: purvalanol A namespace: chebi_ontology alt_id: CHEBI:38935 alt_id: CHEBI:47599 def: "A purvalanol that has formula C19H25ClN6O." [] synonym: "(2R)-2-({6-[(3-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl}amino)-3-methylbutan-1-ol" RELATED [PDBeChem:] synonym: "(2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)-9H-purin-2-yl}amino)-3-methylbutan-1-ol" EXACT IUPAC_NAME [IUPAC:] synonym: "2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine" RELATED [ChemIDplus:] synonym: "2-({6-[(3-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL" RELATED [PDBeChem:] synonym: "C19H25ClN6O" RELATED FORMULA [ChemIDplus:] synonym: "CC(C)[C@H](CO)Nc1nc(Nc2cccc(Cl)c2)c2ncn(C(C)C)c2n1" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)/t15-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=PMXCMJLOPOFPBT-HNNXBMFYSA-N" RELATED InChIKey [ChEBI:] synonym: "Purv" RELATED [ChemIDplus:] xref: Beilstein:8645511 "Beilstein Registry Number" xref: ChemIDplus:212844-53-6 "CAS Registry Number" xref: DrugBank:DB04751 "DrugBank" xref: PDBeChem:P01 "PDBeChem" is_a: CHEBI:38934 ! purvalanol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:47622 name: acetate ester namespace: chebi_ontology alt_id: CHEBI:13244 alt_id: CHEBI:13799 alt_id: CHEBI:22189 alt_id: CHEBI:2406 def: "Any carboxylic ester where the carboxylic acid component is acetic acid." [] synonym: "acetate" RELATED [ChEBI:] synonym: "acetate esters" RELATED [ChEBI:] synonym: "acetates" RELATED [ChEBI:] synonym: "Acetic ester" RELATED [KEGG COMPOUND:] synonym: "Acetyl ester" RELATED [KEGG COMPOUND:] synonym: "acetyl ester" RELATED [UniProt:] synonym: "acetyl esters" RELATED [ChEBI:] synonym: "C2H3O2R" RELATED FORMULA [ChEBI:] synonym: "C2H3O2R" RELATED FORMULA [KEGG COMPOUND:] synonym: "CC(=O)O[*]" RELATED SMILES [ChEBI:] xref: KEGG COMPOUND:C01883 "KEGG COMPOUND" xref: Wikipedia:Acetate#Esters "Wikipedia" is_a: CHEBI:33308 ! carboxylic ester property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:47778 name: glyceride namespace: chebi_ontology alt_id: CHEBI:13730 alt_id: CHEBI:22230 def: "Any ester of glycerol (propane-1,2,3-triol) with fatty acids." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "acylglycerol" RELATED [UniProt:] synonym: "acylglycerols" RELATED [ChEBI:] synonym: "glyceride" EXACT [ChEBI:] synonym: "glycerides" EXACT IUPAC_NAME [IUPAC:] synonym: "glycerides" RELATED [ChEBI:] is_a: CHEBI:35741 ! glycerolipid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:47779 name: aminoglycoside namespace: chebi_ontology synonym: "aminoglycosides" RELATED [ChEBI:] is_a: CHEBI:24400 ! glycoside property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:47857 name: ureas namespace: chebi_ontology alt_id: CHEBI:27220 alt_id: CHEBI:36947 synonym: "." RELATED FORMULA [ChEBI:] synonym: "urea derivatives" RELATED [ChEBI:] is_a: CHEBI:33256 ! primary amide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:47880 name: steroid ester namespace: chebi_ontology alt_id: CHEBI:26762 synonym: "." RELATED FORMULA [ChEBI:] synonym: "steroid esters" RELATED [ChEBI:] xref: KEGG COMPOUND:C15506 "KEGG COMPOUND" is_a: CHEBI:35341 ! steroid is_a: CHEBI:35701 ! ester property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:47898 name: 4'-epidoxorubicin namespace: chebi_ontology def: "An anthracycline that is the 4'-epi-isomer of doxorubicin." [] synonym: "(1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranoside" EXACT IUPAC_NAME [IUPAC:] synonym: "4'-Epiadriamycin" RELATED [ChemIDplus:] synonym: "C27H29NO11" RELATED FORMULA [ChemIDplus:] synonym: "COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO" RELATED SMILES [ChEBI:] synonym: "Epiadriamycin" RELATED [ChemIDplus:] synonym: "epirubicin" RELATED INN [ChemIDplus:] synonym: "epirubicina" RELATED [ChemIDplus:] synonym: "epirubicine" RELATED [ChemIDplus:] synonym: "epirubicinum" RELATED [ChemIDplus:] synonym: "InChI=1S/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t10-,13-,15-,17-,22-,27-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=AOJJSUZBOXZQNB-VTZDEGQISA-N" RELATED InChIKey [ChEBI:] synonym: "pidorubicina" RELATED [ChemIDplus:] synonym: "pidorubicine" RELATED [ChemIDplus:] synonym: "pidorubicinum" RELATED [ChemIDplus:] xref: Beilstein:1445812 "Beilstein Registry Number" xref: ChemIDplus:56420-45-2 "CAS Registry Number" xref: CiteXplore:11432615 "PubMed citation" xref: CiteXplore:15821120 "PubMed citation" xref: CiteXplore:16005104 "PubMed citation" xref: CiteXplore:17604344 "PubMed citation" xref: CiteXplore:18838875 "PubMed citation" xref: DrugBank:DB00445 "DrugBank" xref: KEGG COMPOUND:56420-45-2 "CAS Registry Number" xref: KEGG COMPOUND:C11230 "KEGG COMPOUND" xref: KEGG DRUG:D07901 "KEGG DRUG" xref: Patent:DE2510866 "Patent" xref: Patent:US4058519 "Patent" xref: PDBeChem:DM6 "PDBeChem" xref: Reaxys:1445812 "Reaxys Registry Number" is_a: CHEBI:35315 ! deoxy hexoside is_a: CHEBI:36141 ! quinone is_a: CHEBI:47779 ! aminoglycoside is_a: CHEBI:49322 ! anthracycline antibiotic is_a: CHEBI:63367 ! monosaccharide derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:47908 name: alkanethiol namespace: chebi_ontology alt_id: CHEBI:13812 alt_id: CHEBI:22328 alt_id: CHEBI:2585 def: "An alkanethiol is a compound in which a sulfanyl group, -SH, is attached to an alkyl group." [] synonym: "alkanethiols" RELATED [ChEBI:] synonym: "Alkyl thiol" RELATED [KEGG COMPOUND:] synonym: "alkyl thiol" RELATED [UniProt:] synonym: "alkyl thiols" RELATED [ChEBI:] synonym: "HSR" RELATED FORMULA [KEGG COMPOUND:] synonym: "S[*]" RELATED SMILES [ChEBI:] xref: KEGG COMPOUND:C00812 "KEGG COMPOUND" is_a: CHEBI:29256 ! thiol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:47923 name: tripeptide namespace: chebi_ontology alt_id: CHEBI:27138 alt_id: CHEBI:9742 def: "Any molecule that contains three amino-acid residues connected by peptide linkages." [] synonym: "C6H8N3O4R3" RELATED FORMULA [KEGG COMPOUND:] synonym: "Tripeptide" EXACT [KEGG COMPOUND:] synonym: "tripeptides" RELATED [ChEBI:] xref: KEGG COMPOUND:C00316 "KEGG COMPOUND" is_a: CHEBI:25676 ! oligopeptide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:47989 name: enamine namespace: chebi_ontology def: "An amine RNR'R'' where R has a double bond adjacent to the amine nitrogen." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "[*]\\C([*])=C(\\[*])N([*])[*]" RELATED SMILES [ChEBI:] synonym: "C2NR5" RELATED FORMULA [ChEBI:] synonym: "enamines" RELATED [ChEBI:] is_a: CHEBI:32952 ! amine property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:48009 name: N-glycosyl-1,3,5-triazine namespace: chebi_ontology synonym: "N-glycosyl-1,3,5-triazines" RELATED [ChEBI:] is_a: CHEBI:21731 ! N-glycosyl compound is_a: CHEBI:26588 ! 1,3,5-triazines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:48030 name: tetrapeptide namespace: chebi_ontology alt_id: CHEBI:26931 alt_id: CHEBI:9500 def: "Any molecule that contains four amino-acid residues connected by peptide linkages." [] synonym: "Tetrapeptide" EXACT [KEGG COMPOUND:] synonym: "tetrapeptides" RELATED [ChEBI:] xref: KEGG COMPOUND:C01960 "KEGG COMPOUND" is_a: CHEBI:25676 ! oligopeptide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:48080 name: brefeldin A namespace: chebi_ontology def: "A metabolite from Penicillium brefeldianum that exhibits a wide range of antibiotic activity." [] synonym: "(1R,2E,6S,10E,11aS,13S,14aR)-1,13-dihydroxy-6-methyl-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-4-one" EXACT IUPAC_NAME [IUPAC:] synonym: "[H][C@@]12C[C@H](O)C[C@@]1([H])[C@H](O)\\C=C\\C(=O)O[C@@H](C)CCC\\C=C\\2" RELATED SMILES [ChEBI:] synonym: "ascotoxin" RELATED [ChemIDplus:] synonym: "Brefeldin A" EXACT [ChemIDplus:] synonym: "C16H24O4" RELATED FORMULA [ChEBI:] synonym: "cyanein" RELATED [ChemIDplus:] synonym: "decumbin" RELATED [ChemIDplus:] synonym: "InChI=1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15+/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=KQNZDYYTLMIZCT-KQPMLPITSA-N" RELATED InChIKey [ChEBI:] xref: Beilstein:25191 "Beilstein Registry Number" xref: Beilstein:5282047 "Beilstein Registry Number" xref: ChemIDplus:20350-15-6 "CAS Registry Number" is_a: CHEBI:25105 ! macrolide antibiotic property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:48120 name: anthracycline namespace: chebi_ontology def: "Anthracyclines are polyketides that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "anthracycline" EXACT [ChEBI:] synonym: "anthracyclines" RELATED [ChEBI:] is_a: CHEBI:26188 ! polyketide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:48154 name: sulfur oxide namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "oxides of sulfur" RELATED [ChEBI:] synonym: "Schwefeloxide" RELATED [ChEBI:] synonym: "sulfur oxides" RELATED [ChEBI:] is_a: CHEBI:24836 ! inorganic oxide is_a: CHEBI:26835 ! sulfur molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:4828 name: ergothioneine namespace: chebi_ontology def: "A L-histidine derivative that is N(alpha),N(alpha),N(alpha)-trimethyl-L-histidine in which the hydrogen at position 2 on the imdazole ring is replaced by a mercapto group. A naturally occurring metabolite of histidine with antioxidant properties; abundant in most plants and animals, obtained in animals through the diet." [] synonym: "(2S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trimethylammonio)propanoate" RELATED [ChEBI:] synonym: "(2S)-3-(2-mercapto-1H-imidazol-5-yl)-2-(trimethylazaniumyl)propanoate" EXACT IUPAC_NAME [IUPAC:] synonym: "(alphaS)-alpha-carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-1H-imidazole-4-ethanaminium inner salt" RELATED [ChEBI:] synonym: "(S)-(1-carboxy-2-(2-mercaptoimidazol-4-yl)ethyl)trimethylammonium hydroxide" RELATED [ChemIDplus:] synonym: "2-mercaptohistidine trimethylbetaine" RELATED [ChEBI:] synonym: "3-(2-sulfanylidene-1,3-dihydroimidazol-4-yl)-2-trimethylammonio-propanoate" RELATED [ChEBI:] synonym: "C9H15N3O2S" RELATED FORMULA [ChEBI:] synonym: "C[N+](C)(C)[C@@H](Cc1c[nH]c(S)n1)C([O-])=O" RELATED SMILES [ChEBI:] synonym: "Ergothioneine" EXACT [KEGG COMPOUND:] synonym: "ergothioneine thiol" RELATED [UniProt:] synonym: "ergothionine" RELATED [ChemIDplus:] synonym: "erythrothioneine" RELATED [ChEBI:] synonym: "InChI=1S/C9H15N3O2S/c1-12(2,3)7(8(13)14)4-6-5-10-9(15)11-6/h5,7H,4H2,1-3H3,(H2-,10,11,13,14,15)/t7-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=SSISHJJTAXXQAX-ZETCQYMHSA-N" RELATED InChIKey [ChEBI:] synonym: "L-ergothioneine" RELATED [ChemIDplus:] synonym: "L-thioneine" RELATED [ChemIDplus:] synonym: "sympectothion" RELATED [ChemIDplus:] synonym: "thiolhistidine-betaine" RELATED [ChemIDplus:] synonym: "thiolhistidinebetaine" RELATED [ChEBI:] xref: Beilstein:5755696 "Beilstein Registry Number" xref: ChemIDplus:497-30-3 "CAS Registry Number" xref: CiteXplore:17616140 "PubMed citation" xref: CiteXplore:18670092 "PubMed citation" xref: CiteXplore:18841979 "PubMed citation" xref: HMDB:HMDB03045 "HMDB" xref: KEGG COMPOUND:497-30-3 "CAS Registry Number" xref: KEGG COMPOUND:C05570 "KEGG COMPOUND" xref: MetaCyc:CPD-15276 "MetaCyc" xref: Reaxys:5755696 "Reaxys Registry Number" xref: Reaxys:8411606 "Reaxys Registry Number" xref: Wikipedia:Ergothioneine "Wikipedia" is_a: CHEBI:22860 ! amino-acid betaine is_a: CHEBI:84076 ! L-histidine derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:48337 name: pyrrolopyrazine namespace: chebi_ontology synonym: "pyrrolopyrazines" RELATED [ChEBI:] is_a: CHEBI:27171 ! organic heterobicyclic compound is_a: CHEBI:38101 ! organonitrogen heterocyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:48343 name: disulfide namespace: chebi_ontology def: "Compounds of structure RSSR'." [] synonym: "disulfides" RELATED [ChEBI:] is_a: CHEBI:26835 ! sulfur molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:48369 name: organic bromide salt namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "organic bromide salts" RELATED [ChEBI:] is_a: CHEBI:22925 ! bromide salt is_a: CHEBI:51069 ! organic halide salt property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:48544 name: methanesulfonates namespace: chebi_ontology def: "Esters or salts of methanesulfonic acid." [] synonym: "." RELATED FORMULA [ChEBI:] is_a: CHEBI:33261 ! organosulfur compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:48589 name: piperidones namespace: chebi_ontology synonym: "piperidone" RELATED [ChEBI:] is_a: CHEBI:26151 ! piperidines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:48626 name: pyranoindolizinoquinoline namespace: chebi_ontology synonym: "pyranoindolizinoquinolines" RELATED [ChEBI:] is_a: CHEBI:38101 ! organonitrogen heterocyclic compound is_a: CHEBI:38104 ! oxacycle is_a: CHEBI:38164 ! organic heteropentacyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:48828 name: cobalt(2+) namespace: chebi_ontology alt_id: CHEBI:23337 alt_id: CHEBI:48827 def: "A cobalt cation that has formula Co." [] synonym: "[Co++]" RELATED SMILES [ChEBI:] synonym: "Co" RELATED FORMULA [ChEBI:] synonym: "Co(2+)" RELATED [UniProt:] synonym: "Co(II)" RELATED [KEGG COMPOUND:] synonym: "Co2+" RELATED [ChEBI:] synonym: "Co2+" RELATED [KEGG COMPOUND:] synonym: "COBALT (II) ION" RELATED [PDBeChem:] synonym: "Cobalt(2+)" EXACT [KEGG COMPOUND:] synonym: "cobalt(2+)" EXACT [PDBeChem:] synonym: "cobalt(2+)" EXACT IUPAC_NAME [IUPAC:] synonym: "cobalt(2+) ion" EXACT IUPAC_NAME [IUPAC:] synonym: "cobalt(2+) ion" RELATED [ChEBI:] synonym: "cobalt(II) cation" EXACT IUPAC_NAME [IUPAC:] synonym: "cobalt(II) cation" RELATED [ChEBI:] synonym: "cobaltous ion" RELATED [ChEBI:] synonym: "InChI=1S/Co/q+2" RELATED InChI [ChEBI:] synonym: "InChIKey=XLJKHNWPARRRJB-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] xref: ChemIDplus:22541-53-3 "CAS Registry Number" xref: Gmelin:6853 "Gmelin Registry Number" xref: KEGG COMPOUND:22541-53-3 "CAS Registry Number" xref: KEGG COMPOUND:C00175 "KEGG COMPOUND" xref: PDBeChem:CO "PDBeChem" is_a: CHEBI:23336 ! cobalt cation is_a: CHEBI:30412 ! monoatomic dication is_a: CHEBI:60240 ! divalent metal cation property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:4883 name: ethidium bromide namespace: chebi_ontology def: "An organic bromide salt that has formula C21H20N3.Br." [] synonym: "2,7-diamino-10-ethyl-9-phenylphenanthridinium bromide" RELATED [ChemIDplus:] synonym: "2,7-diamino-9-phenyl-10-ethylphenanthridinium bromide" RELATED [ChemIDplus:] synonym: "3,8-diamino-5-ethyl-6-phenylphenanthridinium bromide" EXACT IUPAC_NAME [IUPAC:] synonym: "[Br-].CC[n+]1c(-c2ccccc2)c2cc(N)ccc2c2ccc(N)cc12" RELATED SMILES [ChEBI:] synonym: "C21H20BrN3" RELATED FORMULA [ChEBI:] synonym: "C21H20N3.Br" RELATED FORMULA [KEGG COMPOUND:] synonym: "Dromilac" RELATED [ChemIDplus:] synonym: "EtBr" RELATED [ChEBI:] synonym: "Ethidium bromide" EXACT [KEGG COMPOUND:] synonym: "Homidium bromide" RELATED [KEGG COMPOUND:] synonym: "InChI=1S/C21H19N3.BrH/c1-2-24-20-13-16(23)9-11-18(20)17-10-8-15(22)12-19(17)21(24)14-6-4-3-5-7-14;/h3-13,23H,2,22H2,1H3;1H" RELATED InChI [ChEBI:] synonym: "InChIKey=ZMMJGEGLRURXTF-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] xref: Beilstein:3642536 "Beilstein Registry Number" xref: ChemIDplus:1239-45-8 "CAS Registry Number" xref: KEGG COMPOUND:1239-45-8 "CAS Registry Number" xref: KEGG COMPOUND:C11161 "KEGG COMPOUND" is_a: CHEBI:48369 ! organic bromide salt property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:48861 name: 2-trans,6-trans,10-trans-geranylgeranyl diphosphate namespace: chebi_ontology alt_id: CHEBI:19786 alt_id: CHEBI:42968 alt_id: CHEBI:5335 def: "The all-trans-isomer of geranylgeranyl diphosphate." [] synonym: "(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl trihydrogen diphosphate" EXACT IUPAC_NAME [IUPAC:] synonym: "(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl trihydrogen diphosphate" RELATED [PDBeChem:] synonym: "all-trans-Geranylgeranyl diphosphate" RELATED [KEGG COMPOUND:] synonym: "all-trans-Geranylgeranyl pyrophosphate" RELATED [KEGG COMPOUND:] synonym: "C20H36O7P2" RELATED FORMULA [KEGG COMPOUND:] synonym: "CC(C)=CCC\\C(C)=C\\CC\\C(C)=C\\CC\\C(C)=C\\COP(O)(=O)OP(O)(O)=O" RELATED SMILES [ChEBI:] synonym: "GERANYLGERANYL DIPHOSPHATE" RELATED [PDBeChem:] synonym: "Geranylgeranyl diphosphate" RELATED [KEGG COMPOUND:] synonym: "Geranylgeranyl pyrophosphate" RELATED [KEGG COMPOUND:] synonym: "GGDP" RELATED [ChemIDplus:] synonym: "InChI=1S/C20H36O7P2/c1-17(2)9-6-10-18(3)11-7-12-19(4)13-8-14-20(5)15-16-26-29(24,25)27-28(21,22)23/h9,11,13,15H,6-8,10,12,14,16H2,1-5H3,(H,24,25)(H2,21,22,23)/b18-11+,19-13+,20-15+" RELATED InChI [ChEBI:] synonym: "InChIKey=OINNEUNVOZHBOX-QIRCYJPOSA-N" RELATED InChIKey [ChEBI:] xref: Beilstein:1896121 "Beilstein Registry Number" xref: ChemIDplus:6699-20-3 "CAS Registry Number" xref: KEGG COMPOUND:6699-20-3 "CAS Registry Number" xref: KEGG COMPOUND:C00353 "KEGG COMPOUND" xref: KNApSAcK:C00000908 "KNApSAcK" xref: LIPID MAPS:LMPR0104010001 "LIPID MAPS instance" xref: PDBeChem:GRG "PDBeChem" is_a: CHEBI:15831 ! geranylgeranyl diphosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:48891 name: thiazolidinone namespace: chebi_ontology synonym: "thiazolidinones" RELATED [ChEBI:] is_a: CHEBI:35622 ! thiazolidines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:48901 name: thiazoles namespace: chebi_ontology def: "An azole in which the five-membered heterocyclic aromatic skeleton contains a N atom and one S atom." [] is_a: CHEBI:38106 ! organosulfur heterocyclic compound is_a: CHEBI:68452 ! azole property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:48923 name: erythromycin namespace: chebi_ontology def: "Any of several wide-spectrum macrolide antibiotics obtained from actinomycete Saccharopolyspora erythraea (formerly known as Streptomyces erythraeus)." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "eritromicina" RELATED [ChEBI:] synonym: "erythromycine" RELATED [ChEBI:] xref: DrugBank:DB00199 "DrugBank" xref: HMDB:HMDB14344 "HMDB" xref: Patent:US2653899 "Patent" xref: Wikipedia:Erythromycin "Wikipedia" is_a: CHEBI:23953 ! erythromycins property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:48956 name: 5-O-phosphono-D-ribofuranosyl diphosphate namespace: chebi_ontology def: "A 5-phosphoribosyl diphosphate that has formula C5H13O14P3." [] synonym: "5-O-phosphono-D-ribofuranose 1-(trihydrogen diphosphate)" EXACT IUPAC_NAME [IUPAC:] synonym: "5-phosphorylribose-1-pyrophosphate" RELATED [ChemIDplus:] synonym: "C5H13O14P3" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/t2-,3-,4-,5?/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=PQGCEDQWHSBAJP-SOOFDHNKSA-N" RELATED InChIKey [ChEBI:] synonym: "O[C@H]1[C@@H](O)C(O[C@@H]1COP(O)(O)=O)OP(O)(=O)OP(O)(O)=O" RELATED SMILES [ChEBI:] synonym: "ribofuranose, 5-(dihydrogen phosphate) 1-(trihydrogen diphosphate)" RELATED [ChemIDplus:] synonym: "ribofuranose, 5-(dihydrogen phosphate) 1-(trihydrogen pyrophosphate)" RELATED [ChemIDplus:] synonym: "ribofuranose, 5-phosphate 1-pyrophosphate" RELATED [ChemIDplus:] xref: Beilstein:1273542 "Beilstein Registry Number" xref: ChemIDplus:97-55-2 "CAS Registry Number" is_a: CHEBI:12164 ! 5-phosphoribosyl diphosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:48958 name: 1,1'-azobis(N,N-dimethylformamide) namespace: chebi_ontology def: "A monoazo compound that has formula C6H12N4O2." [] synonym: "1,1'-azobis(N,N-dimethylformamide)" EXACT [ChemIDplus:] synonym: "3-(N,N-dimethylcarbamoylimido)-1,1-dimethylurea" RELATED [ChemIDplus:] synonym: "azodicarboxylic acid bis-dimethylamide" RELATED [ChemIDplus:] synonym: "C6H12N4O2" RELATED FORMULA [ChEBI:] synonym: "CN(C)C(=O)N=NC(=O)N(C)C" RELATED SMILES [ChEBI:] synonym: "Diamide" RELATED [ChemIDplus:] synonym: "diazenedicarboxylic acid bis(N,N-dimethylamide)" RELATED [ChemIDplus:] synonym: "InChI=1S/C6H12N4O2/c1-9(2)5(11)7-8-6(12)10(3)4/h1-4H3" RELATED InChI [ChEBI:] synonym: "InChIKey=VLSDXINSOMDCBK-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "N,N,N',N'-tetramethylazobisformamide" RELATED [ChemIDplus:] synonym: "N,N,N',N'-tetramethylazodicarboxamide" RELATED [ChemIDplus:] synonym: "N,N,N',N'-tetramethylazoformamide" RELATED [ChemIDplus:] synonym: "N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide" EXACT IUPAC_NAME [IUPAC:] synonym: "tetramethyldiazenedicarboxamide" RELATED [ChemIDplus:] synonym: "TMAD" RELATED [ChemIDplus:] xref: ChemIDplus:10465-78-8 "CAS Registry Number" xref: ChemIDplus:1910409 "Beilstein Registry Number" xref: Gmelin:913769 "Gmelin Registry Number" is_a: CHEBI:48959 ! monoazo compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:48959 name: monoazo compound namespace: chebi_ontology def: "Compounds containing single -N=N- group." [] synonym: "monoazo compounds" EXACT IUPAC_NAME [IUPAC:] synonym: "monoazo compounds" RELATED [ChEBI:] is_a: CHEBI:37533 ! azo compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:49032 name: L-methionine (R)-S-oxide namespace: chebi_ontology def: "The (R)-oxido diastereomer of L-methionine S-oxide." [] synonym: "(2S)-2-amino-4-[(R)-methylsulfinyl]butanoic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "C5H11NO3S" RELATED FORMULA [ChEBI:] synonym: "C[S@@](=O)CC[C@H](N)C(O)=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C5H11NO3S/c1-10(9)3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-,10+/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=QEFRNWWLZKMPFJ-ZXPFJRLXSA-N" RELATED InChIKey [ChEBI:] synonym: "L-Methionine (R)-S-oxide" EXACT [KEGG COMPOUND:] xref: Beilstein:6115068 "Beilstein Registry Number" xref: KEGG COMPOUND:C15998 "KEGG COMPOUND" xref: PDBeChem:SME "PDBeChem" is_a: CHEBI:17016 ! L-methionine S-oxide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:49033 name: methionine S-oxide namespace: chebi_ontology def: "The S-oxide derivative of methionine. It is a biomarker of oxidative stress." [] synonym: "2-amino-4-(methylsulfinyl)butanoic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "C5H11NO3S" RELATED FORMULA [ChEBI:] synonym: "CS(=O)CCC(N)C(O)=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C5H11NO3S/c1-10(9)3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)" RELATED InChI [ChEBI:] synonym: "InChIKey=QEFRNWWLZKMPFJ-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "methionine sulfoxide" RELATED [ChemIDplus:] xref: Beilstein:2206690 "Beilstein Registry Number" xref: ChemIDplus:62697-73-8 "CAS Registry Number" xref: CiteXplore:12576054 "PubMed citation" xref: CiteXplore:24776987 "PubMed citation" xref: DrugBank:DB02235 "DrugBank" xref: HMDB:HMDB02005 "HMDB" xref: MetaCyc:CPD0-1959 "MetaCyc" xref: Reaxys:2206690 "Reaxys Registry Number" is_a: CHEBI:22063 ! S-oxide is_a: CHEBI:25230 ! methionine derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:49104 name: heteroarenecarbaldehyde namespace: chebi_ontology synonym: "heteroarenecarbaldehydes" RELATED [ChEBI:] is_a: CHEBI:17478 ! aldehyde property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:4911 name: etoposide namespace: chebi_ontology def: "A furonaphthodioxole that has formula C29H32O13." [] synonym: "(-)-etoposide" RELATED [DrugBank:] synonym: "(5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside" EXACT IUPAC_NAME [IUPAC:] synonym: "4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-beta-D-glucopyranoside)" RELATED [ChemIDplus:] synonym: "4-demethylepipodophyllotoxin beta-D-ethylideneglucoside" RELATED [ChemIDplus:] synonym: "9-((4,6-O-Ethylidine-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-d)-1,3-dioxol-6(5aH)-one" RELATED [ChemIDplus:] synonym: "[H][C@]12COC(=O)[C@]1([H])[C@H](c1cc(OC)c(O)c(OC)c1)c1cc3OCOc3cc1[C@H]2O[C@@H]1O[C@@H]2CO[C@@H](C)O[C@H]2[C@H](O)[C@H]1O" RELATED SMILES [ChEBI:] synonym: "C29H32O13" RELATED FORMULA [KEGG COMPOUND:] synonym: "Eposin" RELATED BRAND_NAME [DrugBank:] synonym: "Etopophos" RELATED BRAND_NAME [DrugBank:] synonym: "Etoposide" EXACT [KEGG COMPOUND:] synonym: "etoposide" RELATED INN [ChemIDplus:] synonym: "Etoposido" RELATED INN [ChemIDplus:] synonym: "etoposidum" RELATED INN [ChemIDplus:] synonym: "InChI=1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=VJJPUSNTGOMMGY-MRVIYFEKSA-N" RELATED InChIKey [ChEBI:] synonym: "Lastet" RELATED BRAND_NAME [DrugBank:] synonym: "Toposar" RELATED BRAND_NAME [DrugBank:] synonym: "trans-Etoposide" RELATED [DrugBank:] synonym: "Vepesid" RELATED BRAND_NAME [DrugBank:] synonym: "VP-16" RELATED [KEGG COMPOUND:] xref: ChemIDplus:33419-42-0 "CAS Registry Number" xref: DrugBank:DB00773 "DrugBank" xref: KEGG COMPOUND:33419-42-0 "CAS Registry Number" xref: KEGG COMPOUND:C01576 "KEGG COMPOUND" xref: KEGG DRUG:D00125 "KEGG DRUG" xref: Patent:US3524844 "Patent" xref: Wikipedia:Etoposide "Wikipedia" is_a: CHEBI:22798 ! beta-D-glucoside is_a: CHEBI:50307 ! furonaphthodioxole property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:49183 name: phosphatidylcholine(1+) namespace: chebi_ontology alt_id: CHEBI:14802 alt_id: CHEBI:36705 def: "A glycerophosphocholine compound having O-acyl substituents at both the 1- and 2-positions of the glycerol. It is a major constituent of cell membranes." [] synonym: "1,2-Diacyl-sn-glycero-3-phosphocholine" RELATED [KEGG COMPOUND:] synonym: "3-sn-Phosphatidylcholine" RELATED [KEGG COMPOUND:] synonym: "C10H19NO8PR2" RELATED FORMULA [ChEBI:] synonym: "C[N+](C)(C)CCOP(O)(=O)OCC(COC([*])=O)OC([*])=O" RELATED SMILES [ChEBI:] synonym: "Choline phosphatide" RELATED [KEGG COMPOUND:] synonym: "Lecithin" RELATED [KEGG COMPOUND:] synonym: "Lecithol" RELATED [ChemIDplus:] synonym: "PC" RELATED [ChEBI:] synonym: "Phosphatidyl-N-trimethylethanolamine" RELATED [KEGG COMPOUND:] synonym: "phosphatidylcholines" RELATED [ChEBI:] synonym: "Phospholutein" RELATED [ChemIDplus:] xref: ChemIDplus:8002-43-5 "CAS Registry Number" xref: CiteXplore:11306571 "PubMed citation" xref: CiteXplore:11394647 "PubMed citation" xref: CiteXplore:11829744 "PubMed citation" xref: CiteXplore:14756787 "PubMed citation" xref: CiteXplore:14761824 "PubMed citation" xref: CiteXplore:15008874 "PubMed citation" xref: CiteXplore:15223015 "PubMed citation" xref: CiteXplore:16484204 "PubMed citation" xref: CiteXplore:16829536 "PubMed citation" xref: CiteXplore:16882035 "PubMed citation" xref: CiteXplore:18614529 "PubMed citation" xref: CiteXplore:19843309 "PubMed citation" xref: CiteXplore:22809594 "PubMed citation" xref: CiteXplore:22922101 "PubMed citation" xref: CiteXplore:23207112 "PubMed citation" xref: CiteXplore:23452035 "PubMed citation" xref: CiteXplore:23519169 "PubMed citation" xref: CiteXplore:23543734 "PubMed citation" xref: CiteXplore:3196084 "PubMed citation" xref: KEGG COMPOUND:8002-43-5 "CAS Registry Number" xref: KEGG COMPOUND:C00157 "KEGG COMPOUND" xref: Wikipedia:Phosphatidylcholine "Wikipedia" is_a: CHEBI:35267 ! quaternary ammonium ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:49318 name: piperidine antibiotic namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "piperidine antibiotics" RELATED [ChEBI:] is_a: CHEBI:25558 ! organonitrogen heterocyclic antibiotic is_a: CHEBI:26151 ! piperidines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:49319 name: carbocyclic antibiotic namespace: chebi_ontology synonym: "carbocyclic antibiotics" RELATED [ChEBI:] is_a: CHEBI:33598 ! carbocyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:49322 name: anthracycline antibiotic namespace: chebi_ontology alt_id: CHEBI:22573 alt_id: CHEBI:22574 def: "An organic compound that has a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine and which exhibits antibiotic activity." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "anthracycline antibiotics" RELATED [ChEBI:] synonym: "anthracyclines" RELATED [ChEBI:] synonym: "anthracyclins" RELATED [ChEBI:] is_a: CHEBI:48120 ! anthracycline property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:49703 name: latrunculin B namespace: chebi_ontology def: "A macrolide consisting of a 14-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica." [] synonym: "(+)-latrunculin B" RELATED [ChEBI:] synonym: "(4R)-4-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-1,3-thiazolidin-2-one" EXACT IUPAC_NAME [IUPAC:] synonym: "[H][C@]1(CSC(=O)N1)[C@@]1(O)C[C@H]2C[C@@H](CC[C@H](C)\\C=C/CC\\C(C)=C/C(=O)O2)O1" RELATED SMILES [ChEBI:] synonym: "C20H29NO5S" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C20H29NO5S/c1-13-5-3-4-6-14(2)9-18(22)25-16-10-15(8-7-13)26-20(24,11-16)17-12-27-19(23)21-17/h3,5,9,13,15-17,24H,4,6-8,10-12H2,1-2H3,(H,21,23)/b5-3-,14-9-/t13-,15-,16-,17+,20-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=NSHPHXHGRHSMIK-JRIKCGFMSA-N" RELATED InChIKey [ChEBI:] synonym: "Lat B" RELATED [ChEBI:] synonym: "LAT-B" RELATED [ChemIDplus:] synonym: "LATRUNCULIN B" EXACT [PDBeChem:] xref: ChemIDplus:76343-94-7 "CAS Registry Number" xref: CiteXplore:14613176 "PubMed citation" xref: CiteXplore:16499319 "PubMed citation" xref: CiteXplore:18342638 "PubMed citation" xref: CiteXplore:21831923 "PubMed citation" xref: CiteXplore:22138731 "PubMed citation" xref: CiteXplore:22175603 "PubMed citation" xref: CiteXplore:22247475 "PubMed citation" xref: CiteXplore:23341780 "PubMed citation" xref: CiteXplore:23483897 "PubMed citation" xref: CiteXplore:23541521 "PubMed citation" xref: CiteXplore:23727052 "PubMed citation" xref: CiteXplore:23935614 "PubMed citation" xref: PDBeChem:LAB "PDBeChem" xref: Reaxys:5456050 "Reaxys Registry Number" is_a: CHEBI:25106 ! macrolide is_a: CHEBI:46733 ! oxabicycloalkane is_a: CHEBI:48891 ! thiazolidinone is_a: CHEBI:59780 ! cyclic hemiketal property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:49713 name: lithium(1+) namespace: chebi_ontology alt_id: CHEBI:30143 alt_id: CHEBI:49711 def: "An alkali metal cation that has formula Li." [] synonym: "[Li+]" RELATED SMILES [ChEBI:] synonym: "InChI=1S/Li/q+1" RELATED InChI [ChEBI:] synonym: "InChIKey=HBBGRARXTFLTSG-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "Li" RELATED FORMULA [ChEBI:] synonym: "Li(+)" RELATED [IUPAC:] synonym: "Li(+)" RELATED [UniProt:] synonym: "lithium" RELATED [PDBeChem:] synonym: "lithium cation" RELATED [NIST Chemistry WebBook:] synonym: "LITHIUM ION" RELATED [PDBeChem:] synonym: "lithium(1+)" EXACT IUPAC_NAME [IUPAC:] synonym: "lithium(1+) ion" EXACT IUPAC_NAME [IUPAC:] synonym: "lithium(I) cation" EXACT IUPAC_NAME [IUPAC:] synonym: "lithium, ion" RELATED [NIST Chemistry WebBook:] synonym: "Lithium, ion (Li1+)" RELATED [ChemIDplus:] xref: ChemIDplus:17341-24-1 "CAS Registry Number" xref: DrugBank:DB01356 "DrugBank" xref: Gmelin:15205 "Gmelin Registry Number" xref: NIST Chemistry WebBook:17341-24-1 "CAS Registry Number" xref: PDBeChem:LI "PDBeChem" is_a: CHEBI:25414 ! monoatomic monocation is_a: CHEBI:33504 ! alkali metal cation is_a: CHEBI:60242 ! monovalent inorganic cation property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:497734 name: L-thialysine namespace: chebi_ontology alt_id: CHEBI:45515 def: "A cysteine derivative that is the S-(2-aminoethyl) analogue of L-cysteine; reported to have cytotoxic effects." [] synonym: "(2R)-2-amino-3-(2-aminoethylsulfanyl)propanoic acid" RELATED [PDB:] synonym: "(R)-2-amino-3-(2-aminoethylthio)propanoic acid" RELATED [ChEMBL:] synonym: "2-Aminoethylcysteine" RELATED [HMDB:] synonym: "4-Thia-L-lysine" RELATED [HMDB:] synonym: "4-Thialysine" RELATED [HMDB:] synonym: "Aminoethylcysteine" RELATED [ChemIDplus:] synonym: "C5H12N2O2S" RELATED FORMULA [ChEBI:] synonym: "gamma-Thia-lys" RELATED [ChemIDplus:] synonym: "gamma-Thialysine" RELATED [ChemIDplus:] synonym: "InChI=1S/C5H12N2O2S/c6-1-2-10-3-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9)/t4-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=GHSJKUNUIHUPDF-BYPYZUCNSA-N" RELATED InChIKey [ChEBI:] synonym: "L-THIALYSINE" EXACT [PDBeChem:] synonym: "NCCSC[C@H](N)C(O)=O" RELATED SMILES [ChEBI:] synonym: "S-(2-aminoethyl)-L-cysteine" EXACT IUPAC_NAME [IUPAC:] synonym: "S-2-Aminoethyl cysteine" RELATED [ChemIDplus:] synonym: "S-beta-Aminoethyl cysteine" RELATED [ChemIDplus:] synonym: "Thiosine" RELATED [ChemIDplus:] xref: Beilstein:1705488 "Beilstein Registry Number" xref: ChEMBL:17524640 "PubMed citation" xref: ChemIDplus:2936-69-8 "CAS Registry Number" xref: CiteXplore:11370852 "PubMed citation" xref: CiteXplore:17165731 "PubMed citation" xref: CiteXplore:19634897 "PubMed citation" xref: CiteXplore:19685884 "PubMed citation" xref: CiteXplore:7654708 "PubMed citation" xref: Gmelin:1006349 "Gmelin Registry Number" xref: HMDB:HMDB33518 "HMDB" xref: PDBeChem:SLZ "PDBeChem" xref: Reaxys:1705488 "Reaxys Registry Number" xref: Wikipedia:S-Aminoethyl-L-cysteine "Wikipedia" is_a: CHEBI:27532 ! L-cysteine thioether is_a: CHEBI:83822 ! non-proteinogenic L-alpha-amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:50011 name: Calcofluor White namespace: chebi_ontology def: "An organic sodium salt that has formula C40H42N12Na2O10S2." [] synonym: "4,4'-bis((2-anilino-4-(bis(2-hydroxyethyl)amino)-1,3,5-triazin-6-yl)amino)stilbene-2,2'-disulfonic acid, disodium salt" RELATED [ChemIDplus:] synonym: "4,4'-bis((4-anilino-6-bis(2-hydroxyethyl)amino-s-triazin-2-yl)amino)-2,2'-stilbenedisulfonic acid, disodium salt" RELATED [ChemIDplus:] synonym: "[Na+].[Na+].[H]C(=C([H])c1ccc(Nc2nc(Nc3ccccc3)nc(n2)N(CCO)CCO)cc1S([O-])(=O)=O)c1ccc(Nc2nc(Nc3ccccc3)nc(n2)N(CCO)CCO)cc1S([O-])(=O)=O" RELATED SMILES [ChEBI:] synonym: "C.I. 40622" RELATED [ChEBI:] synonym: "C.I. Fluorescent Brightening Agent 28, disodium salt" RELATED [ChemIDplus:] synonym: "C40H42N12Na2O10S2" RELATED FORMULA [ChEBI:] synonym: "Calcofluor White LRP" RELATED [ChemIDplus:] synonym: "Calcofluor White M 2R" RELATED [ChemIDplus:] synonym: "Calcofluor White ST" RELATED [ChemIDplus:] synonym: "Cellufluor" RELATED [ChemIDplus:] synonym: "disodium 2,2'-ethene-1,2-diylbis[5-({4-anilino-6-[bis(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl}amino)benzenesulfonate]" EXACT IUPAC_NAME [IUPAC:] synonym: "disodium 4,4'-bis(6-anilino-(4-(bis(2-hydroxyethyl)amino)-1,3,5-triazin-2-yl)amino)stilbene-2,2'-disulphonate" RELATED [ChemIDplus:] synonym: "Fluorescent Brightener 28" RELATED [ChemIDplus:] synonym: "InChI=1S/C40H44N12O10S2.2Na/c53-21-17-51(18-22-54)39-47-35(41-29-7-3-1-4-8-29)45-37(49-39)43-31-15-13-27(33(25-31)63(57,58)59)11-12-28-14-16-32(26-34(28)64(60,61)62)44-38-46-36(42-30-9-5-2-6-10-30)48-40(50-38)52(19-23-55)20-24-56;;/h1-16,25-26,53-56H,17-24H2,(H,57,58,59)(H,60,61,62)(H2,41,43,45,47,49)(H2,42,44,46,48,50);;/q;2*+1/p-2" RELATED InChI [ChEBI:] synonym: "InChIKey=YJHDFAAFYNRKQE-UHFFFAOYSA-L" RELATED InChIKey [ChEBI:] xref: Beilstein:8385272 "Beilstein Registry Number" xref: ChemIDplus:4193-55-9 "CAS Registry Number" is_a: CHEBI:38700 ! organic sodium salt property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:50047 name: organic amino compound namespace: chebi_ontology def: "A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups." [] synonym: "organic amino compounds" RELATED [ChEBI:] is_a: CHEBI:35352 ! organonitrogen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:50091 name: S-nitrosoglutathione namespace: chebi_ontology def: "A glutathione derivative that has formula C10H16N4O7S." [] synonym: "C10H16N4O7S" RELATED FORMULA [ChEBI:] synonym: "glutathione thionitrite" RELATED [ChemIDplus:] synonym: "GSNO" RELATED [ChemIDplus:] synonym: "InChI=1S/C10H16N4O7S/c11-5(10(19)20)1-2-7(15)13-6(4-22-14-21)9(18)12-3-8(16)17/h5-6H,1-4,11H2,(H,12,18)(H,13,15)(H,16,17)(H,19,20)/t5-,6-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=HYHSBSXUHZOYLX-WDSKDSINSA-N" RELATED InChIKey [ChEBI:] synonym: "L-gamma-glutamyl-S-nitroso-L-cysteinylglycine" EXACT IUPAC_NAME [IUPAC:] synonym: "N-(N-L-gamma-glutamyl-S-nitroso-L-cysteinyl)glycine" RELATED [ChemIDplus:] synonym: "N[C@@H](CCC(=O)N[C@@H](CSN=O)C(=O)NCC(O)=O)C(O)=O" RELATED SMILES [ChEBI:] synonym: "nitrosoglutathione" RELATED [ChemIDplus:] synonym: "SNOG" RELATED [ChemIDplus:] xref: ChemIDplus:3566211 "Beilstein Registry Number" xref: ChemIDplus:57564-91-7 "CAS Registry Number" is_a: CHEBI:24337 ! glutathione derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:50277 name: farnesyl diphosphate namespace: chebi_ontology alt_id: CHEBI:14231 alt_id: CHEBI:24016 def: "A farnesyl phosphate that has formula C15H28O7P2." [] synonym: "3,7,11-trimethyldodeca-2,6,10-trien-1-yl trihydrogen diphosphate" EXACT IUPAC_NAME [IUPAC:] synonym: "C15H28O7P2" RELATED FORMULA [ChEBI:] synonym: "CC(C)=CCCC(C)=CCCC(C)=CCOP(O)(=O)OP(O)(O)=O" RELATED SMILES [ChEBI:] synonym: "farnesyl diphosphate" EXACT [UniProt:] synonym: "farnesyl diphosphates" RELATED [ChEBI:] synonym: "InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)" RELATED InChI [ChEBI:] synonym: "InChIKey=VWFJDQUYCIWHTN-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] xref: Beilstein:1892961 "Beilstein Registry Number" xref: DrugBank:DB07780 "DrugBank" xref: NIST Chemistry WebBook:13058-04-3 "CAS Registry Number" is_a: CHEBI:24018 ! farnesyl phosphate is_a: CHEBI:37531 ! polyprenol diphosphate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:50307 name: furonaphthodioxole namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "furonaphthodioxole" EXACT [ChEBI:] synonym: "furonaphthodioxoles" RELATED [ChEBI:] is_a: CHEBI:38104 ! oxacycle is_a: CHEBI:38163 ! organic heterotetracyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:50312 name: onium compound namespace: chebi_ontology synonym: "onium compound" EXACT [ChEBI:] synonym: "onium compounds" EXACT IUPAC_NAME [IUPAC:] synonym: "onium compounds" RELATED [ChEBI:] is_a: CHEBI:37577 ! heteroatomic molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:50313 name: onium cation namespace: chebi_ontology def: "Mononuclear cations derived by addition of a hydron to a mononuclear parent hydride of the pnictogen, chalcogen and halogen families." [] synonym: "onium cations" EXACT IUPAC_NAME [IUPAC:] synonym: "onium cations" RELATED [ChEBI:] synonym: "onium ion" RELATED [ChEBI:] synonym: "onium ions" RELATED [ChEBI:] is_a: CHEBI:50312 ! onium compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:50334 name: pyridinium ion namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "pyridinium ions" RELATED [ChEBI:] is_a: CHEBI:25697 ! organic cation property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:50403 name: ergostanoid namespace: chebi_ontology synonym: "ergostanoids" RELATED [CBN:] is_a: CHEBI:35341 ! steroid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:50492 name: thiocarbonyl compound namespace: chebi_ontology def: "Any compound containing the thiocarbonyl group, C=S." [] synonym: "thiocarbonyl compounds" RELATED [ChEBI:] is_a: CHEBI:33261 ! organosulfur compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:50584 name: alkyl alcohol namespace: chebi_ontology alt_id: CHEBI:22937 alt_id: CHEBI:50581 def: "An aliphatic alcohol in which the aliphatic alkane chain is substituted by a hydroxy group at unspecified position." [] synonym: "alkyl alcohols" RELATED [ChEBI:] synonym: "butan-1-ols" RELATED [ChEBI:] synonym: "hydroxyalkane" RELATED [ChEBI:] synonym: "hydroxyalkanes" RELATED [ChEBI:] is_a: CHEBI:2571 ! aliphatic alcohol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:50699 name: oligosaccharide namespace: chebi_ontology alt_id: CHEBI:25679 alt_id: CHEBI:35319 alt_id: CHEBI:7758 def: "A compound in which monosaccharide units are joined by glycosidic linkages. The term is commonly used to refer to a defined structure as opposed to a polymer of unspecified length or a homologous mixture. When the linkages are of other types the compounds are regarded as oligosaccharide analogues." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "an oligosaccharide" RELATED [UniProt:] synonym: "O-glycosylglycoside" RELATED [ChEBI:] synonym: "O-glycosylglycosides" RELATED [ChEBI:] synonym: "oligosacarido" RELATED [ChEBI:] synonym: "oligosacaridos" RELATED [IUPAC:] synonym: "Oligosaccharide" EXACT [KEGG COMPOUND:] synonym: "oligosaccharides" EXACT IUPAC_NAME [IUPAC:] xref: KEGG COMPOUND:C00930 "KEGG COMPOUND" is_a: CHEBI:16646 ! carbohydrate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:50772 name: 2-decaprenyl-6-methoxy-3-methyl-1,4-benzoquinone namespace: chebi_ontology def: "A polyprenylbenzoquinone that is 2-decaprenyl-1,4-benzoquinone carrying additional methyl and methoxy substituents at positions 3 and 6 respectively." [] synonym: "3-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaen-1-yl]-5-methoxy-2-methyl-1,4-benzoquinone" RELATED [IUPAC:] synonym: "3-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaen-1-yl]-5-methoxy-2-methylcyclohexa-2,5-diene-1,4-dione" EXACT IUPAC_NAME [IUPAC:] synonym: "5-demethoxyubiquinone-10" RELATED [ChEBI:] synonym: "C58H88O3" RELATED FORMULA [ChEBI:] synonym: "COC1=CC(=O)C(C)=C(C\\C=C(/C)CC\\C=C(/C)CC\\C=C(/C)CC\\C=C(/C)CC\\C=C(/C)CC\\C=C(/C)CC\\C=C(/C)CC\\C=C(/C)CC\\C=C(/C)CCC=C(C)C)C1=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C58H88O3/c1-44(2)23-14-24-45(3)25-15-26-46(4)27-16-28-47(5)29-17-30-48(6)31-18-32-49(7)33-19-34-50(8)35-20-36-51(9)37-21-38-52(10)39-22-40-53(11)41-42-55-54(12)56(59)43-57(61-13)58(55)60/h23,25,27,29,31,33,35,37,39,41,43H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b45-25+,46-27+,47-29+,48-31+,49-33+,50-35+,51-37+,52-39+,53-41+" RELATED InChI [ChEBI:] synonym: "InChIKey=DLBRMPAESNEOJM-RGIWONJESA-N" RELATED InChIKey [ChEBI:] xref: Beilstein:3079996 "Beilstein Registry Number" xref: CiteXplore:5166547 "PubMed citation" xref: HMDB:HMDB60251 "HMDB" xref: LIPID MAPS:LMPR02010032 "LIPID MAPS instance" xref: MetaCyc:CPD-11660 "MetaCyc" xref: Reaxys:3079996 "Reaxys Registry Number" is_a: CHEBI:35795 ! polyprenylbenzoquinone property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:50860 name: organic molecular entity namespace: chebi_ontology alt_id: CHEBI:25700 alt_id: CHEBI:33244 def: "Any molecular entity that contains carbon." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "organic compounds" RELATED [ChEBI:] synonym: "organic entity" RELATED [ChEBI:] synonym: "organic molecular entities" RELATED [ChEBI:] synonym: "organic molecules" RELATED [ChEBI:] is_a: CHEBI:33582 ! carbon group molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:50893 name: azaarene namespace: chebi_ontology synonym: "azaarenes" RELATED [ChEBI:] is_a: CHEBI:33833 ! heteroarene is_a: CHEBI:38101 ! organonitrogen heterocyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:50902 name: genotoxin namespace: chebi_ontology def: "A role played by a chemical compound to induce direct or indirect DNA damage. Such damage can potentially lead to the formation of a malignant tumour, but DNA damage does not lead inevitably to the creation of cancerous cells." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "genotoxic agent" RELATED [ChEBI:] synonym: "genotoxic agents" RELATED [ChEBI:] synonym: "genotoxins" RELATED [ChEBI:] xref: Wikipedia:Genotoxicity "Wikipedia" is_a: CHEBI:52209 ! aetiopathogenetic role property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:50906 name: role namespace: chebi_ontology def: "A role is particular behaviour which a material entity may exhibit." [] property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:50994 name: primary amino compound namespace: chebi_ontology def: "A compound formally derived from ammonia by replacing one hydrogen atom by an organyl group." [] synonym: "primary amino compounds" RELATED [ChEBI:] is_a: CHEBI:50047 ! organic amino compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:50995 name: secondary amino compound namespace: chebi_ontology def: "A compound formally derived from ammonia by replacing two hydrogen atoms by organyl groups." [] synonym: "secondary amino compounds" RELATED [ChEBI:] is_a: CHEBI:50047 ! organic amino compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:50996 name: tertiary amino compound namespace: chebi_ontology def: "A compound formally derived from ammonia by replacing three hydrogen atoms by organyl groups." [] synonym: "tertiary amino compounds" RELATED [ChEBI:] is_a: CHEBI:50047 ! organic amino compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:51026 name: macrocycle namespace: chebi_ontology def: "A cyclic compound containing nine or more atoms as part of the cyclic system." [] synonym: "macrocycle" EXACT IUPAC_NAME [IUPAC:] synonym: "macrocycles" RELATED [ChEBI:] synonym: "Makrocyclen" RELATED [ChEBI:] synonym: "makrocyclische Verbindungen" RELATED [ChEBI:] synonym: "Makrozyklen" RELATED [ChEBI:] synonym: "makrozyklische Verbindungen" RELATED [ChEBI:] xref: Wikipedia:Macrocycle "Wikipedia" is_a: CHEBI:33595 ! cyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:51069 name: organic halide salt namespace: chebi_ontology synonym: "organic halide salts" RELATED [ChEBI:] is_a: CHEBI:24868 ! organic salt property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:51086 name: chemical role namespace: chebi_ontology def: "A role played by the molecular entity or part thereof within a chemical context." [] is_a: CHEBI:50906 ! role property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:51143 name: nitrogen molecular entity namespace: chebi_ontology alt_id: CHEBI:25556 alt_id: CHEBI:7594 synonym: "." RELATED FORMULA [ChEBI:] synonym: "nitrogen compounds" RELATED [ChEBI:] synonym: "nitrogen molecular entities" RELATED [ChEBI:] synonym: "Nitrogenous compounds" RELATED [KEGG COMPOUND:] xref: KEGG COMPOUND:C06061 "KEGG COMPOUND" is_a: CHEBI:33302 ! pnictogen molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:51151 name: dipolar compound namespace: chebi_ontology def: "An organic molecule that is electrically neutral carrying a positive and a negative charge in one of its major canonical descriptions. In most dipolar compounds the charges are delocalized; however the term is also applied to species where this is not the case." [] synonym: "dipolar compounds" RELATED [ChEBI:] is_a: CHEBI:72695 ! organic molecule property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:51214 name: diamminedichloroplatinum namespace: chebi_ontology synonym: "Cl2H6N2Pt" RELATED FORMULA [ChEBI:] synonym: "diammine(dichloro)platinum" RELATED [ChEBI:] synonym: "diamminedichloridoplatinum" EXACT IUPAC_NAME [IUPAC:] synonym: "diamminedichloridoplatinum(II)" EXACT IUPAC_NAME [IUPAC:] synonym: "diamminedichloroplatinum" EXACT IUPAC_NAME [IUPAC:] synonym: "diamminedichloroplatinum(II)" EXACT IUPAC_NAME [IUPAC:] synonym: "diammineplatinum dichloride" RELATED [NIST Chemistry WebBook:] xref: Gmelin:101110 "Gmelin Registry Number" xref: NIST Chemistry WebBook:14913-33-8 "CAS Registry Number" is_a: CHEBI:33862 ! platinum coordination entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:5123 name: fluphenazine namespace: chebi_ontology def: "A member of the class of phenothiazines that is 10H-phenothiazine having a trifluoromethyl subsitituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at the N-10 position." [] synonym: "1-(2-hydroxyethyl)-4-(3-(trifluoromethyl-10-phenothiazinyl)propyl)-piperazine" RELATED [ChemIDplus:] synonym: "10-(3'-(4''-(beta-hydroxyethyl)-1''-piperazinyl)-propyl)-3-trifluoromethylphenothiazine" RELATED [ChemIDplus:] synonym: "10-(3-(2-hydroxyethyl)piperazinopropyl)-2-(trifluoromethyl)phenothiazine" RELATED [NIST Chemistry WebBook:] synonym: "2-(4-(3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl)-1-piperazinyl)ethanol" RELATED [NIST Chemistry WebBook:] synonym: "2-(4-{3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl}piperazin-1-yl)ethanol" EXACT IUPAC_NAME [IUPAC:] synonym: "2-(trifluoromethyl)-10-(3-(1-(beta-hydroxyethyl)-4-piperazinyl)propyl)phenothiazine" RELATED [ChemIDplus:] synonym: "4-(3-(-trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol" RELATED [ChemIDplus:] synonym: "4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-1-piperazineethanol" RELATED [ChemIDplus:] synonym: "4-(3-(2-trifluoromethyl-10-phenothiazyl)-propyl)-1-piperazineethanol" RELATED [ChemIDplus:] synonym: "C22H26F3N3OS" RELATED FORMULA [KEGG COMPOUND:] synonym: "flufenazina" RELATED [ChemIDplus:] synonym: "Fluorfenazine" RELATED [DrugBank:] synonym: "Fluorophenazine" RELATED [DrugBank:] synonym: "Fluorphenazine" RELATED [DrugBank:] synonym: "Fluphenazine" EXACT [KEGG COMPOUND:] synonym: "fluphenazine" RELATED INN [KEGG DRUG:] synonym: "fluphenazinum" RELATED INN [ChemIDplus:] synonym: "InChI=1S/C22H26F3N3OS/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29/h1-2,4-7,16,29H,3,8-15H2" RELATED InChI [ChEBI:] synonym: "InChIKey=PLDUPXSUYLZYBN-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "OCCN1CCN(CCCN2c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1" RELATED SMILES [ChEBI:] synonym: "Triflumethazine" RELATED [DrugBank:] xref: Beilstein:1189506 "Beilstein Registry Number" xref: Beilstein:61643 "Beilstein Registry Number" xref: ChemIDplus:69-23-8 "CAS Registry Number" xref: CiteXplore:1650428 "PubMed citation" xref: CiteXplore:5128930 "PubMed citation" xref: DrugBank:DB00623 "DrugBank" xref: Gmelin:1231182 "Gmelin Registry Number" xref: HMDB:HMDB14761 "HMDB" xref: KEGG COMPOUND:69-23-8 "CAS Registry Number" xref: KEGG COMPOUND:C07010 "KEGG COMPOUND" xref: KEGG DRUG:D07977 "KEGG DRUG" xref: NIST Chemistry WebBook:69-23-8 "CAS Registry Number" xref: Patent:GB829246 "Patent" xref: Patent:GB833474 "Patent" xref: Patent:US3058979 "Patent" xref: Patent:US3194733 "Patent" xref: Reaxys:61643 "Reaxys Registry Number" xref: Wikipedia:Fluphenazine "Wikipedia" is_a: CHEBI:37143 ! organofluorine compound is_a: CHEBI:38093 ! phenothiazines is_a: CHEBI:46845 ! N-alkylpiperazine property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:51276 name: thioureas namespace: chebi_ontology def: "Compounds of general formula RR'NC(=S)NR''R'''." [] is_a: CHEBI:50492 ! thiocarbonyl compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:51323 name: cinchona alkaloid namespace: chebi_ontology def: "An alkaloid based on a cinchonan skeleton." [] synonym: "cinchona alkaloids" RELATED [ChEBI:] is_a: CHEBI:26509 ! quinoline alkaloid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:51475 name: naphthohydroquinone namespace: chebi_ontology synonym: "." RELATED FORMULA [ChEBI:] synonym: "naphthohydroquinone" EXACT [ChEBI:] synonym: "naphthohydroquinones" RELATED [ChEBI:] is_a: CHEBI:24646 ! hydroquinones property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:51689 name: enone namespace: chebi_ontology def: "An alpha,beta-unsaturated ketone of general formula R(1)R(2)C=CR(3)-C(=O)R(4) (R(4) =/= H) in which the C=O function is conjugated to a C=C double bond at the alpha,beta position." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "[*]\\C([*])=C(\\[*])C([*])=O" RELATED SMILES [ChEBI:] synonym: "C3OR4" RELATED FORMULA [ChEBI:] synonym: "enones" RELATED [ChEBI:] xref: Wikipedia:Enone "Wikipedia" is_a: CHEBI:51721 ! alpha,beta-unsaturated ketone is_a: CHEBI:78840 ! olefinic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:51702 name: enoate ester namespace: chebi_ontology def: "An alpha,beta-unsaturated carboxylic ester of general formula R(1)R(2)C=CR(3)-C(=O)OR(4) (R(4) =/= H) in which the ester C=O function is conjugated to a C=C double bond at the alpha,beta position." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "[*]\\C([*])=C(\\[*])C(=O)O[*]" RELATED SMILES [ChEBI:] synonym: "C3O2R4" RELATED FORMULA [ChEBI:] synonym: "enoate" RELATED [ChEBI:] synonym: "enoate esters" RELATED [ChEBI:] synonym: "enoates" RELATED [ChEBI:] is_a: CHEBI:51737 ! alpha,beta-unsaturated carboxylic ester is_a: CHEBI:78840 ! olefinic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:51721 name: alpha,beta-unsaturated ketone namespace: chebi_ontology def: "A ketone of general formula R(1)R(2)C=CR(3)-C(=O)R(4) (R(4) =/= H) or R(1)C#C-C(=O)R(2) (R(2) =/= H) in which the ketonic C=O function is conjugated to an unsaturated C-C bond at the alpha,beta position." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "alpha,beta-unsaturated ketones" RELATED [ChEBI:] is_a: CHEBI:17087 ! ketone property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:51737 name: alpha,beta-unsaturated carboxylic ester namespace: chebi_ontology def: "A carboxylic ester of general formula R(1)R(2)C=CR(3)-C(=O)OR(4) (R(4) =/= H) or R(1)C#C-C(=O)OR(2) (R(2) =/= H) in which the ester C=O function is conjugated to an unsaturated C-C bond at the alpha,beta position." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "alpha,beta-unsaturated carboxylic esters" RELATED [ChEBI:] is_a: CHEBI:33308 ! carboxylic ester property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:51838 name: haloketone namespace: chebi_ontology def: "A ketone containing a halo group." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "halogenoketone" RELATED [ChEBI:] synonym: "halogenoketones" RELATED [ChEBI:] synonym: "haloketones" RELATED [ChEBI:] is_a: CHEBI:17087 ! ketone is_a: CHEBI:36684 ! organohalogen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:51839 name: alpha-haloketone namespace: chebi_ontology def: "A haloketone in which the halogen and oxo substituents are on adjacent carbon atoms." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "alpha-halogenoketone" RELATED [ChEBI:] synonym: "alpha-halogenoketones" RELATED [ChEBI:] synonym: "alpha-haloketones" RELATED [ChEBI:] is_a: CHEBI:51838 ! haloketone property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:51840 name: chloroketone namespace: chebi_ontology def: "A ketone containing a chloro substituent." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "chloroketones" RELATED [ChEBI:] is_a: CHEBI:36683 ! organochlorine compound is_a: CHEBI:51838 ! haloketone property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:51841 name: alpha-chloroketone namespace: chebi_ontology def: "A chloroketone in which the chlorine and oxo substituents are on adjacent carbon atoms." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "alpha-chloroketones" RELATED [ChEBI:] is_a: CHEBI:51839 ! alpha-haloketone is_a: CHEBI:51840 ! chloroketone property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:51958 name: organic polycyclic compound namespace: chebi_ontology synonym: "organic polycyclic compounds" RELATED [ChEBI:] is_a: CHEBI:33635 ! polycyclic compound is_a: CHEBI:33832 ! organic cyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:51959 name: organic tricyclic compound namespace: chebi_ontology synonym: "organic tricyclic compounds" RELATED [ChEBI:] is_a: CHEBI:51958 ! organic polycyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:52206 name: biochemical role namespace: chebi_ontology def: "A biological role played by the molecular entity or part thereof within a biochemical context." [] is_a: CHEBI:24432 ! biological role property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:52209 name: aetiopathogenetic role namespace: chebi_ontology def: "A role played by the molecular entity or part thereof which causes the development of a pathological process." [] synonym: "etiopathogenetic agent" RELATED [ChEBI:] synonym: "etiopathogenetic role" RELATED [ChEBI:] is_a: CHEBI:24432 ! biological role property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:52210 name: pharmacological role namespace: chebi_ontology def: "A biological role which describes how a drug interacts within a biological system and how the interactions affect its medicinal properties." [] is_a: CHEBI:24432 ! biological role property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:52289 name: wortmannin namespace: chebi_ontology def: "A delta-lactone that has formula C23H24O8." [] synonym: "(1S,6bR,9aS,11R,11bR)-9a,11b-dimethyl-1-[(methyloxy)methyl]-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate" EXACT IUPAC_NAME [IUPAC:] synonym: "[H][C@@]12CCC(=O)[C@@]1(C)C[C@@H](OC(C)=O)C1=C2C(=O)c2occ3C(=O)O[C@H](COC)[C@@]1(C)c23" RELATED SMILES [ChEBI:] synonym: "C23H24O8" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=QDLHCMPXEPAAMD-QAIWCSMKSA-N" RELATED InChIKey [ChEBI:] synonym: "Wartmannin" RELATED [ChemIDplus:] xref: Beilstein:67676 "Beilstein Registry Number" xref: ChemIDplus:19545-26-7 "CAS Registry Number" xref: CiteXplore:22003059 "PubMed citation" xref: CiteXplore:22056625 "PubMed citation" xref: CiteXplore:22524784 "PubMed citation" xref: KEGG COMPOUND:19545-26-7 "CAS Registry Number" xref: KEGG COMPOUND:C15181 "KEGG COMPOUND" xref: KNApSAcK:C00023672 "KNApSAcK" xref: PDBeChem:KWT "PDBeChem" xref: Reaxys:67676 "Reaxys Registry Number" is_a: CHEBI:18946 ! delta-lactone is_a: CHEBI:38164 ! organic heteropentacyclic compound is_a: CHEBI:3992 ! cyclic ketone is_a: CHEBI:47622 ! acetate ester property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:52310 name: 1-NA-PP1 namespace: chebi_ontology def: "A pyrazolopyrimidine that has formula C19H19N5." [] synonym: "1-(1,1-dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine" RELATED [ChEBI:] synonym: "1-tert-butyl-3-naphthalen-1-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine" EXACT IUPAC_NAME [IUPAC:] synonym: "4-Amino-1-tert-butyl-3-(1'-naphthyl)pyrazolo[3,4-d]pyrimidine" RELATED [SUBMITTER:] synonym: "C19H19N5" RELATED FORMULA [ChEBI:] synonym: "CC(C)(C)n1nc(-c2cccc3ccccc23)c2c(N)ncnc12" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C19H19N5/c1-19(2,3)24-18-15(17(20)21-11-22-18)16(23-24)14-10-6-8-12-7-4-5-9-13(12)14/h4-11H,1-3H3,(H2,20,21,22)" RELATED InChI [ChEBI:] synonym: "InChIKey=XSHQBIXMLULFEV-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] xref: Beilstein:8275174 "Beilstein Registry Number" xref: SUBMITTER:221243-82-9 "CAS Registry Number" is_a: CHEBI:38669 ! pyrazolopyrimidine property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:52565 name: acylglycerophosphoserine namespace: chebi_ontology synonym: "acylglycerophosphoserines" RELATED [ChEBI:] is_a: CHEBI:35766 ! glycerophosphoserine property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:52646 name: leptomycin B namespace: chebi_ontology def: "A leptomycin having a (2E,10E,12E,16Z,18E)-double bond configuration as well as an ethyl substituent at position 17." [] synonym: "(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-19-[(2S,3S)-3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl]-8-oxononadeca-2,10,12,16,18-pentaenoic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "antibiotic ATS 1287B" RELATED [ChEBI:] synonym: "Antibiotic CI 940" RELATED [ChemIDplus:] synonym: "Antibiotic CL 1957A" RELATED [ChemIDplus:] synonym: "Antibiotic PD 114720" RELATED [ChEBI:] synonym: "ATS 1287B" RELATED [ChEBI:] synonym: "C33H48O6" RELATED FORMULA [ChEBI:] synonym: "CCC(\\C=C\\[C@@H]1OC(=O)C=C[C@@H]1C)=C\\[C@H](C)C\\C=C\\C(C)=C\\[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)C\\C(C)=C\\C(O)=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C33H48O6/c1-9-28(14-15-29-24(5)13-16-31(36)39-29)19-22(3)12-10-11-21(2)17-25(6)32(37)27(8)33(38)26(7)18-23(4)20-30(34)35/h10-11,13-17,19-20,22,24-27,29,33,38H,9,12,18H2,1-8H3,(H,34,35)/b11-10+,15-14+,21-17+,23-20+,28-19-/t22-,24+,25-,26+,27-,29+,33-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=YACHGFWEQXFSBS-XYERBDPFSA-N" RELATED InChIKey [ChEBI:] synonym: "LMB" RELATED [ChEBI:] xref: Beilstein:7958583 "Beilstein Registry Number" xref: Beilstein:8299374 "Beilstein Registry Number" xref: ChemIDplus:87081-35-4 "CAS Registry Number" xref: CiteXplore:10430904 "PubMed citation" xref: CiteXplore:6874586 "PubMed citation" xref: CiteXplore:9683540 "PubMed citation" xref: Reaxys:8299374 "Reaxys Registry Number" is_a: CHEBI:52651 ! leptomycin property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:52651 name: leptomycin namespace: chebi_ontology def: "A complex, very long chain, polyunsaturated fatty acid whose core structure comprises 8-oxononadeca-2,10,12,16,18-pentaenoic acid having methyl substituents at positions 3, 5, 7, 9, 11 and 15 and a 3,6-dihydropyran-6-one-2-yl group at position 19." [] synonym: "leptomycins" RELATED [ChEBI:] xref: ChemIDplus:88026-21-5 "CAS Registry Number" xref: CiteXplore:6874586 "PubMed citation" is_a: CHEBI:24654 ! hydroxy fatty acid is_a: CHEBI:25000 ! lactone is_a: CHEBI:26208 ! polyunsaturated fatty acid is_a: CHEBI:27283 ! very long-chain fatty acid is_a: CHEBI:35819 ! branched-chain fatty acid is_a: CHEBI:59644 ! oxo fatty acid is_a: CHEBI:79020 ! alpha,beta-unsaturated monocarboxylic acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:52717 name: bortezomib namespace: chebi_ontology alt_id: CHEBI:41143 def: "L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome." [] synonym: "[(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "bortezomib" RELATED INN [ChemIDplus:] synonym: "C19H25BN4O4" RELATED FORMULA [ChEBI:] synonym: "CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=GXJABQQUPOEUTA-RDJZCZTQSA-N" RELATED InChIKey [ChEBI:] synonym: "N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N(alpha)-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide" EXACT IUPAC_NAME [IUPAC:] synonym: "N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE" RELATED [PDBeChem:] synonym: "PS 341" RELATED [ChemIDplus:] synonym: "PS-341" RELATED [ChemIDplus:] synonym: "Velcade" RELATED BRAND_NAME [DrugBank:] xref: ChemIDplus:179324-69-7 "CAS Registry Number" xref: CiteXplore:18484921 "PubMed citation" xref: CiteXplore:18980173 "PubMed citation" xref: CiteXplore:21504411 "PubMed citation" xref: CiteXplore:21865767 "PubMed citation" xref: DrugBank:DB00188 "DrugBank" xref: KEGG DRUG:D03150 "KEGG DRUG" xref: PDBeChem:BO2 "PDBeChem" xref: Reaxys:8723817 "Reaxys Registry Number" xref: Wikipedia:Bortezomib "Wikipedia" is_a: CHEBI:22475 ! amino acid amide is_a: CHEBI:38314 ! pyrazines is_a: CHEBI:84144 ! L-phenylalanine derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:529996 name: cytochalasin D namespace: chebi_ontology def: "An organic heterotricyclic compound that is a mycotoxin produced by Helminthosporium and other moulds which is cell permeable and a potent inhibitor of actin polymerisation and DNA synthesis." [] synonym: "(3S,3aR,4S,6S,7E,10S,12R,13E,15R,15aR)-3-benzyl-6,12-dihydroxy-4,10,12-trimethyl-5-methylene-1,11-dioxo-2,3,3a,4,5,6,6a,9,10,11,12,15-dodecahydro-1H-cycloundeca[d]isoindol-15-yl acetate" EXACT IUPAC_NAME [IUPAC:] synonym: "7,18-Dihydroxy-10-phenyl-5,16,18-trimethyl-(11)cytochalas-21-acetoxy-6(12),13,19-trien-17-one" RELATED [ChemIDplus:] synonym: "[H][C@]12[C@H](Cc3ccccc3)NC(=O)[C@]11[C@H](OC(C)=O)\\C=C\\[C@@](C)(O)C(=O)[C@@H](C)C\\C=C\\C1[C@H](O)C(=C)[C@H]2C" RELATED SMILES [ChEBI:] synonym: "C30H37NO6" RELATED FORMULA [ChEBI:] synonym: "Cytohalasin D" RELATED [ChemIDplus:] synonym: "InChI=1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9+,15-14+/t17-,18+,22?,23-,24+,25-,26+,29+,30+/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=SDZRWUKZFQQKKV-FJUULPFHSA-N" RELATED InChIKey [ChEBI:] synonym: "Lygosporin A" RELATED [ChemIDplus:] synonym: "Zygosporin A" RELATED [ChemIDplus:] xref: Beilstein:1632828 "Beilstein Registry Number" xref: ChemIDplus:22144-77-0 "CAS Registry Number" xref: CiteXplore:20010439 "PubMed citation" xref: CiteXplore:22305779 "PubMed citation" xref: CiteXplore:22684244 "PubMed citation" xref: CiteXplore:22728040 "PubMed citation" xref: CiteXplore:23615686 "PubMed citation" xref: CiteXplore:5800426 "PubMed citation" xref: CiteXplore:7199049 "PubMed citation" xref: PDBeChem:CY9 "PDBeChem" xref: Reaxys:1632828 "Reaxys Registry Number" xref: Wikipedia:Cytochalasin_D "Wikipedia" is_a: CHEBI:22315 ! alkaloid is_a: CHEBI:23528 ! cytochalasin is_a: CHEBI:26878 ! tertiary alcohol is_a: CHEBI:26979 ! organic heterotricyclic compound is_a: CHEBI:35681 ! secondary alcohol is_a: CHEBI:3992 ! cyclic ketone is_a: CHEBI:47622 ! acetate ester is_a: CHEBI:74222 ! gamma-lactam property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:53019 name: glycan G00008 namespace: chebi_ontology def: "A dolichyl diphosphooligosaccharide compound consisting of a branched tetradecasaccharide attached to the dolichyl chain via a diphosphate linkage." [] synonym: "(C5H8)nC108H184N2O77P2" RELATED FORMULA [ChEBI:] synonym: "(Glc)3(GlcNAc)2(Man)9(PP-Dol)1" RELATED [KEGG GLYCAN:] xref: KEGG GLYCAN:G00008 "KEGG GLYCAN" is_a: CHEBI:15926 ! dolichyl diphosphooligosaccharide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:53233 name: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide namespace: chebi_ontology def: "The bromide salt of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium." [] synonym: "2-(4,5-dimethyl-1,3-thiazol-2-yl)-3,5-diphenyl-2H-tetrazol-3-ium bromide" RELATED [IUPAC:] synonym: "3-(4,5-dimethyl-1,3-thiazol-2-yl)-2,5-diphenyl-2H-tetrazol-3-ium bromide" EXACT IUPAC_NAME [IUPAC:] synonym: "3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide" RELATED [ChEBI:] synonym: "3-(4,5-Dimethylthiazolyl)-2,5-diphenyltetrazolium bromide" RELATED [ChemIDplus:] synonym: "3-(4,5-Dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide" RELATED [ChemIDplus:] synonym: "[Br-].Cc1nc(sc1C)-[n+]1nc(nn1-c1ccccc1)-c1ccccc1" RELATED SMILES [ChEBI:] synonym: "C18H16BrN5S" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C18H16N5S.BrH/c1-13-14(2)24-18(19-13)23-21-17(15-9-5-3-6-10-15)20-22(23)16-11-7-4-8-12-16;/h3-12H,1-2H3;1H/q+1;/p-1" RELATED InChI [ChEBI:] synonym: "InChIKey=AZKSAVLVSZKNRD-UHFFFAOYSA-M" RELATED InChIKey [ChEBI:] synonym: "Methylthiazoletetrazolium" RELATED [ChemIDplus:] synonym: "MMT Tetrazolium" RELATED [ChemIDplus:] synonym: "MTT" RELATED [ChemIDplus:] synonym: "Thiazolyl blue" RELATED [ChemIDplus:] synonym: "Thiazolyl Blue Monotetrazolium" RELATED [ChemIDplus:] synonym: "Thiazolyl blue tetrazolium bromide" RELATED [ChemIDplus:] synonym: "TMCHB" RELATED [ChemIDplus:] xref: Beilstein:3825277 "Beilstein Registry Number" xref: ChemIDplus:298-93-1 "CAS Registry Number" xref: CiteXplore:11164558 "PubMed citation" xref: CiteXplore:11479950 "PubMed citation" xref: CiteXplore:14693038 "PubMed citation" xref: CiteXplore:23262421 "PubMed citation" xref: CiteXplore:23266052 "PubMed citation" xref: CiteXplore:23275136 "PubMed citation" xref: CiteXplore:23296098 "PubMed citation" xref: CiteXplore:23379693 "PubMed citation" xref: CiteXplore:23388083 "PubMed citation" xref: CiteXplore:23399301 "PubMed citation" xref: CiteXplore:23416182 "PubMed citation" xref: CiteXplore:23465060 "PubMed citation" xref: CiteXplore:23468003 "PubMed citation" xref: CiteXplore:23531555 "PubMed citation" xref: CiteXplore:23543357 "PubMed citation" xref: CiteXplore:23578702 "PubMed citation" xref: CiteXplore:23656417 "PubMed citation" xref: CiteXplore:23660215 "PubMed citation" xref: CiteXplore:7538090 "PubMed citation" xref: CiteXplore:7994925 "PubMed citation" xref: CiteXplore:9895235 "PubMed citation" is_a: CHEBI:48369 ! organic bromide salt property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:53745 name: 6-azauracil namespace: chebi_ontology def: "A 1,2,4-triazine compound having oxo-substituents at the 3- and 5-positions." [] synonym: "1,2,4-Triazine-3,5(2H,4H)-dione" RELATED [ChemIDplus:] synonym: "1,2,4-triazine-3,5(2H,4H)-dione" EXACT IUPAC_NAME [IUPAC:] synonym: "1,2,4-Triazine-3,5-diol" RELATED [ChemIDplus:] synonym: "4(6)-Azauracil" RELATED [ChemIDplus:] synonym: "as-Triazine-3,5(2H,4H)-dione" RELATED [ChemIDplus:] synonym: "as-Triazine-3,5-diol" RELATED [ChemIDplus:] synonym: "Azauracil" RELATED [ChemIDplus:] synonym: "C3H3N3O2" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C3H3N3O2/c7-2-1-4-6-3(8)5-2/h1H,(H2,5,6,7,8)" RELATED InChI [ChEBI:] synonym: "InChIKey=SSPYSWLZOPCOLO-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "O=c1cn[nH]c(=O)[nH]1" RELATED SMILES [ChEBI:] synonym: "s-Triazine-3,5(2H,4H)-dione" RELATED [NIST Chemistry WebBook:] xref: Beilstein:116472 "Beilstein Registry Number" xref: ChemIDplus:461-89-2 "CAS Registry Number" xref: Gmelin:464327 "Gmelin Registry Number" xref: NIST Chemistry WebBook:461-89-2 "CAS Registry Number" is_a: CHEBI:39410 ! 1,2,4-triazines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:55417 name: maleimides namespace: chebi_ontology def: "Compounds containing a cyclic dicarboximide skeleton in which the two carboacyl groups on nitrogen together with the nitrogen itself form a 1H-pyrrole-2,5-dione structure." [] synonym: "." RELATED FORMULA [ChEBI:] is_a: CHEBI:35356 ! dicarboximide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:556075 name: radicicol namespace: chebi_ontology alt_id: CHEBI:47650 alt_id: CHEBI:47652 alt_id: CHEBI:68728 def: "An antifungal macrolactone antibiotic, obtained from Diheterospora chlamydosporia and Chaetomium chiversii that inhibits protein tyrosine kinase and heat shock protein 90 (Hsp90)." [] synonym: "(1aR,2Z,4E,14R,15aR)-8-chloro-9,11-dihydroxy-14-methyl-1a,14,15,15a-tetrahydro-6H-oxireno[e][2]benzoxacyclotetradecine-6,12(7H)-dione" EXACT IUPAC_NAME [IUPAC:] synonym: "C18H17ClO6" RELATED FORMULA [ChEBI:] synonym: "C[C@@H]1C[C@H]2O[C@@H]2\\C=C/C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3-/t9-,14-,15-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=WYZWZEOGROVVHK-GTMNPGAYSA-N" RELATED InChIKey [ChEBI:] synonym: "Monorden" RELATED [ChemIDplus:] synonym: "monorden" RELATED [ChEBI:] synonym: "RADICICOL" EXACT [PDBeChem:] xref: ChemIDplus:12772-57-5 "CAS Registry Number" xref: Chemspider:20137057 "Chemspider" xref: CiteXplore:16232632 "PubMed citation" xref: CiteXplore:16920739 "PubMed citation" xref: CiteXplore:18667483 "PubMed citation" xref: CiteXplore:19101477 "PubMed citation" xref: CiteXplore:20093793 "PubMed citation" xref: CiteXplore:20961859 "PubMed citation" xref: CiteXplore:21800052 "PubMed citation" xref: DrugBank:DB03758 "DrugBank" xref: PDBeChem:RDC "PDBeChem" xref: Reaxys:15865423 "Reaxys Registry Number" xref: Wikipedia:Radicicol "Wikipedia" is_a: CHEBI:25105 ! macrolide antibiotic is_a: CHEBI:32955 ! epoxide is_a: CHEBI:33853 ! phenols is_a: CHEBI:3992 ! cyclic ketone is_a: CHEBI:51689 ! enone is_a: CHEBI:83403 ! monochlorobenzenes property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:5653 name: hemiacetal namespace: chebi_ontology def: "A compound having the general formula RR'C(OH)OR'' (R'' =/= H)." [] synonym: "CH2O2R2" RELATED FORMULA [KEGG COMPOUND:] synonym: "Hemiacetal" EXACT [KEGG COMPOUND:] synonym: "hemiacetals" EXACT IUPAC_NAME [IUPAC:] synonym: "hemiacetals" RELATED [ChEBI:] synonym: "OC([*])O[*]" RELATED SMILES [ChEBI:] xref: KEGG COMPOUND:C01707 "KEGG COMPOUND" is_a: CHEBI:30879 ! alcohol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:5686 name: heterocyclic compound namespace: chebi_ontology def: "A cyclic compound having as ring members atoms of at least two different elements." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "compuesto heterociclico" RELATED [IUPAC:] synonym: "compuestos heterociclicos" RELATED [IUPAC:] synonym: "heterocycle" RELATED [ChEBI:] synonym: "Heterocyclic compound" EXACT [KEGG COMPOUND:] synonym: "heterocyclic compounds" RELATED [ChEBI:] is_a: CHEBI:33595 ! cyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:569624 name: papulacandin B namespace: chebi_ontology def: "A papulacandin that is papulacandin A in which the (2E,4E)-deca-2,4-dienoyl chain at the O-(6') position is replaced by a (2E,4Z,6E)-8-hydroxydeca-2,4,6-trienoyl chain. It is the major carbohydrate-containing antibiotic from the deuteromycetous fungus Papularia sphaerosperma which shows potent antifungal activity against Candida albicans." [] synonym: "(1S,3'R,4'R,5'R,6'R)-3',5,7-trihydroxy-5'-({6-O-[(2E,4Z,6E)-8-hydroxydeca-2,4,6-trienoyl]-beta-D-galactopyranosyl}oxy)-6'-(hydroxymethyl)-3',4',5',6'-tetrahydro-3H-spiro[2-benzofuran-1,2'-pyran]-4'-yl (2E,4E,7S,8E,10E,14S)-7-hydroxy-8,14-dimethylhexadeca-2,4,8,10-tetraenoate" EXACT IUPAC_NAME [IUPAC:] synonym: "C47H64O17" RELATED FORMULA [ChEBI:] synonym: "CC[C@H](C)CC\\C=C\\C=C(/C)[C@@H](O)C\\C=C\\C=C\\C(=O)O[C@@H]1[C@@H](O)[C@@]2(OCc3cc(O)cc(O)c23)O[C@H](CO)[C@H]1O[C@@H]1O[C@H](COC(=O)\\C=C\\C=C/C=C/C(O)CC)[C@H](O)[C@H](O)[C@H]1O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C47H64O17/c1-5-28(3)17-11-9-12-18-29(4)33(51)20-14-10-16-22-38(54)62-44-43(35(25-48)64-47(45(44)58)39-30(26-60-47)23-32(50)24-34(39)52)63-46-42(57)41(56)40(55)36(61-46)27-59-37(53)21-15-8-7-13-19-31(49)6-2/h7-10,12-16,18-19,21-24,28,31,33,35-36,40-46,48-52,55-58H,5-6,11,17,20,25-27H2,1-4H3/b8-7-,12-9+,14-10+,19-13+,21-15+,22-16+,29-18+/t28-,31?,33-,35+,36+,40-,41-,42+,43+,44-,45+,46-,47-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=UJLFRJFJTPPIOK-RZGJRGQUSA-N" RELATED InChIKey [ChEBI:] synonym: "papulacandin-B" RELATED [ChEBI:] xref: Beilstein:7682569 "Beilstein Registry Number" xref: ChemIDplus:61032-80-2 "CAS Registry Number" xref: CiteXplore:20711516 "PubMed citation" xref: CiteXplore:3735029 "PubMed citation" xref: CiteXplore:380990 "PubMed citation" xref: CiteXplore:6396177 "PubMed citation" xref: CiteXplore:7440418 "PubMed citation" xref: CiteXplore:852996 "PubMed citation" xref: Reaxys:7682569 "Reaxys Registry Number" xref: Wikipedia:Papulacandin_B "Wikipedia" is_a: CHEBI:26979 ! organic heterotricyclic compound is_a: CHEBI:63353 ! disaccharide derivative is_a: CHEBI:72596 ! papulacandin property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:57248 name: echinocandin namespace: chebi_ontology def: "Any one of a family of large lipopeptides that are inhibitors of the enzyme 1,3-beta-glucan synthase, thus damaging fungal cell walls. Echinocandins are fungicidal against most Candida spp and fungistatic against Aspergillus spp." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "echinocandins" RELATED [ChEBI:] is_a: CHEBI:46895 ! lipopeptide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:582124 name: myriocin namespace: chebi_ontology def: "An amino acid-based antibiotic derived from certain thermophilic fungi; acts as a potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis. Myriocin also possesses immunosuppressant activity." [] synonym: "(2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid" RELATED [ChEBI:] synonym: "(2S,3R,4R,6E)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "antibiotic ISP-I" RELATED [ChEBI:] synonym: "C21H39NO6" RELATED FORMULA [ChEBI:] synonym: "CCCCCCC(=O)CCCCCC\\C=C\\C[C@@H](O)[C@H](O)[C@@](N)(CO)C(O)=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C21H39NO6/c1-2-3-4-10-13-17(24)14-11-8-6-5-7-9-12-15-18(25)19(26)21(22,16-23)20(27)28/h9,12,18-19,23,25-26H,2-8,10-11,13-16,22H2,1H3,(H,27,28)/b12-9+/t18-,19+,21+/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=ZZIKIHCNFWXKDY-GNTQXERDSA-N" RELATED InChIKey [ChEBI:] synonym: "Thermozymocidin" RELATED [ChemIDplus:] xref: Beilstein:5113331 "Beilstein Registry Number" xref: ChEMBL:15679316 "PubMed citation" xref: ChemIDplus:35891-70-4 "CAS Registry Number" xref: CiteXplore:21456524 "PubMed citation" xref: CiteXplore:23178537 "PubMed citation" xref: CiteXplore:23659342 "PubMed citation" xref: CiteXplore:23802886 "PubMed citation" xref: CiteXplore:23957439 "PubMed citation" xref: CiteXplore:24141140 "PubMed citation" xref: CiteXplore:24395529 "PubMed citation" xref: CiteXplore:24456332 "PubMed citation" xref: Reaxys:5113331 "Reaxys Registry Number" xref: Wikipedia:Myriocin "Wikipedia" is_a: CHEBI:35785 ! sphingoid is_a: CHEBI:59755 ! alpha-amino fatty acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:58945 name: organophosphate oxoanion namespace: chebi_ontology def: "An organic phosphoric acid derivative in which one or more oxygen atoms of the phosphate group(s) has been deprotonated." [] synonym: "." RELATED FORMULA [ChEBI:] synonym: "organophosphate oxoanions" RELATED [ChEBI:] is_a: CHEBI:25696 ! organic anion is_a: CHEBI:26079 ! phosphoric acid derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:59062 name: polymyxin namespace: chebi_ontology def: "Polymyxins are antibiotics with a general structure consisting of a cyclic peptide with a long hydrophobic tail. They disrupt the structure of the bacterial cell membrane by interacting with its phospholipids. Polymyxins are produced by the Gram-positive bacterium Bacillus polymyxa and are selectively toxic for Gram-negative bacteria." [] synonym: "polymyxins" RELATED [ChEBI:] is_a: CHEBI:24533 ! heterodetic cyclic peptide is_a: CHEBI:46895 ! lipopeptide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:59063 name: polymyxin B2 namespace: chebi_ontology def: "A polymyxin having a 6-methylheptanoyl group at the amino terminus." [] synonym: "4,10-anhydro[N-(6-methylheptanoyl)-L-2,4-diaminobutanoyl-L-threonyl-L-2,4-diaminobutanoyl-L-2,4-diaminobutanoyl-L-2,4-diaminobutanoyl-D-phenylalanyl-L-leucyl-L-2,4-diaminobutanoyl-L-2,4-diaminobutanoyl-L-threonine]" EXACT IUPAC_NAME [IUPAC:] synonym: "C55H96N16O13" RELATED FORMULA [ChEBI:] synonym: "CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCN)NC1=O)[C@@H](C)O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C55H96N16O13/c1-30(2)12-10-11-15-43(74)62-35(16-22-56)50(79)71-45(33(6)73)55(84)67-38(19-25-59)47(76)66-40-21-27-61-54(83)44(32(5)72)70-51(80)39(20-26-60)64-46(75)36(17-23-57)65-52(81)41(28-31(3)4)68-53(82)42(29-34-13-8-7-9-14-34)69-48(77)37(18-24-58)63-49(40)78/h7-9,13-14,30-33,35-42,44-45,72-73H,10-12,15-29,56-60H2,1-6H3,(H,61,83)(H,62,74)(H,63,78)(H,64,75)(H,65,81)(H,66,76)(H,67,84)(H,68,82)(H,69,77)(H,70,80)(H,71,79)/t32-,33-,35+,36+,37+,38+,39+,40+,41+,42-,44+,45+/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=SGPYLFWAQBAXCZ-RUDZPDEXSA-N" RELATED InChIKey [ChEBI:] xref: Beilstein:8185631 "Beilstein Registry Number" xref: CiteXplore:13058849 "PubMed citation" xref: KEGG COMPOUND:1404-26-8 "CAS Registry Number" xref: KEGG COMPOUND:C11612 "KEGG COMPOUND" xref: KEGG DRUG:D08401 "KEGG DRUG" xref: LIPID MAPS:LMPK14000008 "LIPID MAPS instance" is_a: CHEBI:59062 ! polymyxin property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:59080 name: N-\{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residue namespace: chebi_ontology def: "An N-glycan residue involved in post-translational modification of proteins." [] synonym: "(Glc)1(GlcNAc)2(Man)9(Asn)1" RELATED [KEGG GLYCAN:] synonym: "C80H132N4O62" RELATED FORMULA [ChEBI:] synonym: "N-{alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-Asn residue" RELATED [ChEBI:] xref: SUBMITTER:G00010 "KEGG GLYCAN" is_a: CHEBI:59108 ! N(4)-glycosylated L-asparagine residue property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:59082 name: N-\{alpha-Glc-(1->3)-alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residue namespace: chebi_ontology def: "An N-glycan residue involved in post-translational modification of proteins." [] synonym: "(Glc)2(GlcNAc)2(Man)9(Asn)1" RELATED [KEGG GLYCAN:] synonym: "C86H142N4O67" RELATED FORMULA [ChEBI:] synonym: "N-{alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-Asn residue" RELATED [ChEBI:] xref: SUBMITTER:G00171 "KEGG GLYCAN" is_a: CHEBI:59108 ! N(4)-glycosylated L-asparagine residue property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:59108 name: N(4)-glycosylated L-asparagine residue namespace: chebi_ontology def: "An L-asparagine residue having a glycosyl moiety attached to the side-chain amide nitrogen." [] synonym: "N(4)-glycosylated L-asparagine residues" RELATED [ChEBI:] is_a: CHEBI:33710 ! alpha-amino-acid residue property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:59202 name: straight-chain fatty acid namespace: chebi_ontology def: "Any fatty acid whose skeletal carbon atoms form an unbranched open chain." [] synonym: "straight-chain fatty acids" RELATED [ChEBI:] is_a: CHEBI:35366 ! fatty acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:59579 name: alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc namespace: chebi_ontology def: "A branched N-glycan derivative that is an undecasaccharide derivative consisting of nine D-mannosyl residues and two N-acetylglucosamine residues (one at the reducing end)." [] synonym: "alpha-D-mannopyranosyl-(1->2)-alpha-D-mannopyranosyl-(1->2)-alpha-D-mannopyranosyl-(1->3)-[alpha-D-mannopyranosyl-(1->2)-alpha-D-mannopyranosyl-(1->3)-[alpha-D-mannopyranosyl-(1->2)-alpha-D-mannopyranosyl-(1->6)]-alpha-D-mannopyranosyl-(1->6)]-beta-D-mannopyranosyl-(1->4)-2-acetamido-2-deoxy-beta-D-glucopyranosyl-(1->4)-2-acetamido-2-deoxy-D-glucopyranose" EXACT IUPAC_NAME [IUPAC:] synonym: "alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->3)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->3)-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)]-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-2-acetamido-2-deoxy-beta-D-glucosyl-(1->4)-2-acetamido-2-deoxy-D-glucose" RELATED [ChEBI:] synonym: "alpha-D-Manp-(1->2)-alpha-D-Manp-(1->2)-alpha-D-Manp-(1->3)-[alpha-D-Manp-(1->2)-alpha-D-Manp-(1->3)-[alpha-D-Manp-(1->2)-alpha-D-Manp-(1->6)]-alpha-D-Manp-(1->6)]-beta-D-Manp-(1->4)-beta-D-GlcpNAc-(1->4)-D-GlcpNAc" RELATED [ChEBI:] synonym: "alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-GlcNAc" RELATED [ChEBI:] synonym: "alpha-Manp-(1->2)-alpha-Manp-(1->2)-alpha-Manp-(1->3)-[alpha-Manp-(1->2)-alpha-Manp-(1->3)-[alpha-Manp-(1->2)-alpha-Manp-(1->6)]-alpha-Manp-(1->6)]-beta-Manp-(1->4)-beta-GlcpNAc-(1->4)-GlcpNAc" RELATED [ChEBI:] synonym: "C70H118N2O56" RELATED FORMULA [ChEBI:] synonym: "CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O[C@@H]3O[C@H](CO[C@H]4O[C@H](CO[C@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]5O[C@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]5O)[C@@H](O)[C@H](O[C@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]5O[C@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]5O)[C@@H]4O)[C@@H](O)[C@H](O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]4O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]4O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]4O)[C@@H]3O)[C@H](O)[C@H]2NC(C)=O)[C@@H]1O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C70H118N2O56/c1-14(82)71-27-38(93)52(23(10-80)110-60(27)107)121-61-28(72-15(2)83)39(94)53(24(11-81)118-61)122-66-51(106)55(124-69-59(46(101)35(90)21(8-78)116-69)128-70-58(45(100)34(89)22(9-79)117-70)127-65-49(104)42(97)31(86)18(5-75)113-65)37(92)26(120-66)12-108-62-50(105)54(123-68-57(44(99)33(88)20(7-77)115-68)126-64-48(103)41(96)30(85)17(4-74)112-64)36(91)25(119-62)13-109-67-56(43(98)32(87)19(6-76)114-67)125-63-47(102)40(95)29(84)16(3-73)111-63/h16-70,73-81,84-107H,3-13H2,1-2H3,(H,71,82)(H,72,83)/t16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51+,52-,53-,54+,55+,56+,57+,58+,59+,60?,61+,62+,63-,64-,65-,66+,67+,68-,69-,70-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=DINOPBPYOCMGGD-VEDJBHDQSA-N" RELATED InChIKey [ChEBI:] synonym: "Man9(GlcNAc)2" RELATED [KEGG GLYCAN:] xref: Beilstein:4215262 "Beilstein Registry Number" xref: CiteXplore:14527957 "PubMed citation" xref: KEGG GLYCAN:G00374 "KEGG GLYCAN" is_a: CHEBI:22485 ! glucosamine oligosaccharide is_a: CHEBI:71274 ! mannooligosaccharide derivative is_a: CHEBI:71275 ! N-glycan derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:59644 name: oxo fatty acid namespace: chebi_ontology def: "Any fatty acid containing at least one aldehydic or ketonic group in addition to the carboxylic acid group." [] synonym: "oxo fatty acids" RELATED [ChEBI:] xref: CiteXplore:6434570 "PubMed citation" xref: CiteXplore:8454196 "PubMed citation" xref: CiteXplore:8638935 "PubMed citation" is_a: CHEBI:25754 ! oxo carboxylic acid is_a: CHEBI:35366 ! fatty acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:59650 name: amino fatty acid namespace: chebi_ontology def: "A fatty acid containing at least one amino substituent." [] synonym: "amino FA" RELATED [ChEBI:] synonym: "amino fatty acids" RELATED [ChEBI:] synonym: "carboxylated base" RELATED [ChEBI:] synonym: "carboxylated bases" RELATED [ChEBI:] synonym: "lipoamino acid" RELATED [ChEBI:] synonym: "lipoamino acids" RELATED [ChEBI:] is_a: CHEBI:32952 ! amine is_a: CHEBI:33709 ! amino acid is_a: CHEBI:60690 ! nitrogen-containing fatty acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:59676 name: nystatins namespace: chebi_ontology def: "A polyene antifungal antibiotic complex containing three biologically active components, A1, A2 and A3. Produced by Streptococcus noursei, S. aureus and other Streptococcus species." [] xref: Patent:US2832719 "Patent" xref: Patent:US3517100 "Patent" is_a: CHEBI:25105 ! macrolide antibiotic property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:5975 name: iron chelate namespace: chebi_ontology synonym: "Iron chelate" EXACT [KEGG COMPOUND:] xref: KEGG COMPOUND:C06704 "KEGG COMPOUND" is_a: CHEBI:33892 ! iron coordination entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:59755 name: alpha-amino fatty acid namespace: chebi_ontology def: "A fatty acid with an amino substituent at position C-2." [] synonym: "a-amino fatty acid" RELATED [ChEBI:] synonym: "a-amino fatty acids" RELATED [ChEBI:] synonym: "alpha-amino FA" RELATED [ChEBI:] synonym: "alpha-amino fatty acids" RELATED [ChEBI:] xref: CiteXplore:3279209 "PubMed citation" is_a: CHEBI:33704 ! alpha-amino acid is_a: CHEBI:59650 ! amino fatty acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:59769 name: acetal namespace: chebi_ontology def: "An organooxygen compound having the structure RR'C(OR'')(OR''') (R'', R''' =/= H). Mixed acetals have R'' and R''' groups which differ." [] synonym: "acetals" RELATED [ChEBI:] is_a: CHEBI:36963 ! organooxygen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:59770 name: cyclic acetal namespace: chebi_ontology def: "An acetal in the molecule of which the acetal carbon and one or both oxygen atoms thereon are members of a ring." [] synonym: "cyclic acetals" RELATED [ChEBI:] is_a: CHEBI:59769 ! acetal property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:59772 name: hemiketal namespace: chebi_ontology def: "A hemiacetal having the structure RR'C(OH)R'' (R, R', R'' =/= H), derived from a ketone by formal addition of an alcohol to the carbonyl group." [] synonym: "hemiketals" RELATED [ChEBI:] is_a: CHEBI:5653 ! hemiacetal property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:59777 name: ketal namespace: chebi_ontology def: "An acetal of formula R2C(OR)2 (R =/= H) derived from a ketone by replacement of the oxo group by two hydrocarbyloxy groups. The class name 'ketals', once abandoned by IUPAC, has been reinstated as a subclass of acetals." [] synonym: "ketals" RELATED [ChEBI:] is_a: CHEBI:59769 ! acetal property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:59779 name: cyclic ketal namespace: chebi_ontology def: "A ketal in the molecule of which the ketal carbon and one or both oxygen atoms thereon are members of a ring." [] synonym: "cyclic ketals" RELATED [ChEBI:] is_a: CHEBI:38104 ! oxacycle is_a: CHEBI:59777 ! ketal property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:59780 name: cyclic hemiketal namespace: chebi_ontology def: "A hemiacetal having the structure R2C(OH)OR (R =/= H), derived from a ketone by formal addition of an alcohol to the carbonyl group. The term 'cyclic hemiketals', once abandoned by IUPAC, has been reinstated as a subclass of hemiacetals." [] synonym: "cyclic hemiketals" RELATED [ChEBI:] is_a: CHEBI:38131 ! lactol is_a: CHEBI:59772 ! hemiketal property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:59814 name: L-alpha-amino acid anion namespace: chebi_ontology def: "Conjugate base of an L-alpha-amino acid arising from deprotonation of the C-1 carboxy group." [] synonym: "C2H3NO2R" RELATED FORMULA [ChEBI:] synonym: "C[C@H](N)C([O-])=O" RELATED SMILES [ChEBI:] synonym: "L-alpha-amino carboxylate" RELATED [ChEBI:] is_a: CHEBI:33558 ! alpha-amino-acid anion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:59831 name: enyne namespace: chebi_ontology def: "An acetylenic and an olefinic compound containing a carbon chain that contains a carbon-carbon double bond and a carbon-carbon triple bond." [] synonym: "enynes" RELATED [ChEBI:] is_a: CHEBI:73474 ! acetylenic compound is_a: CHEBI:78840 ! olefinic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:59999 name: chemical substance namespace: chebi_ontology def: "A chemical substance is a portion of matter of constant composition, composed of molecular entities of the same type or of different types." [] synonym: "Chemische Substanz" RELATED [ChEBI:] is_a: CHEBI:24431 ! chemical entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:60004 name: mixture namespace: chebi_ontology def: "A mixture is a chemical substance composed of multiple molecules, at least two of which are of a different kind." [] synonym: "Mischung" RELATED [ChEBI:] is_a: CHEBI:59999 ! chemical substance property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:600520 name: micafungin namespace: chebi_ontology alt_id: CHEBI:473847 alt_id: CHEBI:530001 alt_id: CHEBI:533643 alt_id: CHEBI:533785 def: "A cyclic hexapeptide echinocandin antibiotic which exerts its effect by inhibiting the synthesis of 1,3-beta-D-glucan, an integral component of the fungal cell wall. It is used as the acetic acid salt for the treatment of invasive candidiasis, and of aspergillosis in patients who are refractory to, or intolerant of, other therapy." [] synonym: "5-[(1S,2S)-2-{(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-20-[(1R)-3-amino-1-hydroxy-3-oxopropyl]-2,11,12,15-tetrahydroxy-6-[(1R)-1-hydroxyethyl]-16-methyl-5,8,14,19,22,25-hexaoxo-9-[(4-{5-[4-(pentyloxy)phenyl]isoxazol-3-yl}benzoyl)amino]tetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-23-yl}-1,2-dihydroxyethyl]-2-hydroxyphenyl hydrogen sulfate" EXACT IUPAC_NAME [IUPAC:] synonym: "5.1:6-anhydro{(4R,5R)-4,5-dihydroxy-N(2)-(4-{5-[4-(pentyloxy)phenyl]isoxazol-3-yl}benzoyl)-L-ornithyl-L-threonyl-(4R)-4-hydroxy-L-prolyl-(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonyl-(3R)-3-hydroxy-L-glutaminyl-(3S,4S)-3-hydroxy-4-methyl-L-proline}" EXACT IUPAC_NAME [IUPAC:] synonym: "C56H71N9O23S" RELATED FORMULA [ChEBI:] synonym: "CCCCCOc1ccc(cc1)-c1cc(no1)-c1ccc(cc1)C(=O)N[C@H]1C[C@@H](O)[C@@H](O)NC(=O)[C@@H]2[C@@H](O)[C@@H](C)CN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC1=O)[C@@H](C)O)[C@H](O)[C@@H](O)c1ccc(O)c(OS(O)(=O)=O)c1)[C@H](O)CC(N)=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C56H71N9O23S/c1-4-5-6-17-86-32-14-11-28(12-15-32)39-21-33(63-87-39)27-7-9-29(10-8-27)49(75)58-34-20-38(70)52(78)62-54(80)45-46(72)25(2)23-65(45)56(82)43(37(69)22-41(57)71)60-53(79)44(48(74)47(73)30-13-16-36(68)40(18-30)88-89(83,84)85)61-51(77)35-19-31(67)24-64(35)55(81)42(26(3)66)59-50(34)76/h7-16,18,21,25-26,31,34-35,37-38,42-48,52,66-70,72-74,78H,4-6,17,19-20,22-24H2,1-3H3,(H2,57,71)(H,58,75)(H,59,76)(H,60,79)(H,61,77)(H,62,80)(H,83,84,85)/t25-,26+,31+,34-,35-,37+,38+,42-,43-,44-,45-,46-,47-,48-,52+/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=PIEUQSKUWLMALL-YABMTYFHSA-N" RELATED InChIKey [ChEBI:] synonym: "micafungin" RELATED INN [ChemIDplus:] synonym: "micafungin" RELATED INN [KEGG DRUG:] synonym: "Mycamine" RELATED [ChemIDplus:] xref: Beilstein:9610508 "Beilstein Registry Number" xref: ChEMBL:17194830 "PubMed citation" xref: ChEMBL:17307974 "PubMed citation" xref: ChEMBL:17325217 "PubMed citation" xref: ChEMBL:17325225 "PubMed citation" xref: ChEMBL:17420211 "PubMed citation" xref: ChEMBL:17785512 "PubMed citation" xref: ChemIDplus:235114-32-6 "CAS Registry Number" xref: DrugBank:DB01141 "DrugBank" xref: KEGG DRUG:235114-32-6 "CAS Registry Number" xref: KEGG DRUG:D08218 "KEGG DRUG" is_a: CHEBI:57248 ! echinocandin property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:60240 name: divalent metal cation namespace: chebi_ontology def: "A metal cation with a valence of two." [] synonym: "a divalent metal cation" RELATED [UniProt:] is_a: CHEBI:25213 ! metal cation is_a: CHEBI:64641 ! divalent inorganic cation property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:60242 name: monovalent inorganic cation namespace: chebi_ontology def: "An atom or small molecule with a positive charge that does not contain carbon in covalent linkage, with a valency of one." [] synonym: "a monovalent cation" RELATED [UniProt:] is_a: CHEBI:36915 ! inorganic cation property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:60247 name: silver ion namespace: chebi_ontology def: "A silver atom having a net electric charge." [] is_a: CHEBI:33966 ! elemental silver is_a: CHEBI:36914 ! inorganic ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:60248 name: nickel ion namespace: chebi_ontology def: "A nickel atom having a net electric charge." [] is_a: CHEBI:36914 ! inorganic ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:60249 name: lead ion namespace: chebi_ontology def: "A lead atom having a net electric charge." [] is_a: CHEBI:36914 ! inorganic ion is_a: CHEBI:37193 ! elemental lead property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:60252 name: lead cation namespace: chebi_ontology def: "A lead atom having a positive net electric charge." [] is_a: CHEBI:25213 ! metal cation is_a: CHEBI:60249 ! lead ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:60253 name: silver cation namespace: chebi_ontology is_a: CHEBI:33515 ! transition element cation is_a: CHEBI:60247 ! silver ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:60258 name: EC 3.4.* (hydrolases acting on peptide bond) inhibitor namespace: chebi_ontology alt_id: CHEBI:76763 def: "A hydrolase inhibitor that interferes with the action of any hydrolase acting on peptide bonds (peptidase), EC 3.4.*.*)." [] synonym: "EC 3.4.* (hydrolase acting on peptide bond) inhibitor" RELATED [ChEBI:] synonym: "EC 3.4.* (hydrolase acting on peptide bonds) inhibitors" RELATED [ChEBI:] synonym: "EC 3.4.* (hydrolases acting on peptide bond) inhibitors" RELATED [ChEBI:] synonym: "EC 3.4.* (peptidase) inhibitor" RELATED [ChEBI:] synonym: "EC 3.4.* (peptidase) inhibitors" RELATED [ChEBI:] synonym: "EC 3.4.* inhibitor" RELATED [ChEBI:] synonym: "EC 3.4.* inhibitors" RELATED [ChEBI:] synonym: "inhibitor of hydrolases acting on peptide bond (EC 3.4.*)" RELATED [ChEBI:] synonym: "inhibitors of hydrolases acting on peptide bond (EC 3.4.*)" RELATED [ChEBI:] synonym: "peptidase inhibitors" RELATED [ChEBI:] synonym: "protease inhibitor" RELATED [ChEBI:] synonym: "protease inhibitors" RELATED [ChEBI:] is_a: CHEBI:76759 ! EC 3.* (hydrolase) inhibitor property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:60272 name: aluminium ion namespace: chebi_ontology def: "An aluminium atom having a net electric charge." [] synonym: "aluminum ion" RELATED [ChEBI:] is_a: CHEBI:33628 ! elemental aluminium is_a: CHEBI:36914 ! inorganic ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:60690 name: nitrogen-containing fatty acid namespace: chebi_ontology def: "Any fatty acid containing nitrogen as either a substituent or a replacement for a methylene carbon." [] synonym: "N-containing fatty acid" RELATED [ChEBI:] synonym: "N-containing fatty acids" RELATED [ChEBI:] synonym: "nitrogen-containing fatty acids" RELATED [ChEBI:] is_a: CHEBI:35366 ! fatty acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:60783 name: nucleoside analogue namespace: chebi_ontology def: "An analogue of a nucleoside, being an N-glycosyl compound in which the nitrogen-containing moiety is a modified nucleotide base. They are commonly used as antiviral products to prevent viral replication in infected cells." [] synonym: "nucleoside analogues" RELATED [ChEBI:] is_a: CHEBI:21731 ! N-glycosyl compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:60832 name: tubulin modulator namespace: chebi_ontology def: "Any substance that interacts with tubulin to inhibit or promote polymerisation of microtubules." [] synonym: "tubulin modulators" RELATED [ChEBI:] is_a: CHEBI:52210 ! pharmacological role property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:60836 name: phytochelatin namespace: chebi_ontology def: "A family of peptides related to glutathione and composed of (gamma-Glu-Cys)n-Gly where n is in the range 2-11." [] synonym: "(C8H11NO4S)nC2H6N2O2" RELATED FORMULA [ChEBI:] synonym: "phytochelatins" RELATED [ChEBI:] xref: ChemIDplus:98726-08-0 "CAS Registry Number" xref: CiteXplore:10889232 "PubMed citation" xref: Wikipedia:Phytochelatin "Wikipedia" is_a: CHEBI:16670 ! peptide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:60911 name: racemate namespace: chebi_ontology def: "A racemate is an equimolar mixture of a pair of enantiomers." [] synonym: "melange racemique" RELATED [ChEBI:] synonym: "racemates" RELATED [ChEBI:] synonym: "racemic mixture" RELATED [ChEBI:] is_a: CHEBI:60004 ! mixture property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:60971 name: aminophospholipid namespace: chebi_ontology def: "A phospholipid that contains one or more amino groups." [] synonym: "aminophospholipids" RELATED [ChEBI:] is_a: CHEBI:16247 ! phospholipid is_a: CHEBI:50047 ! organic amino compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:60980 name: beta-glucoside namespace: chebi_ontology def: "A glucoside in which the anomeric carbon of the glycosidic bond is in a beta configuration" [] synonym: "beta-glucosides" RELATED [ChEBI:] is_a: CHEBI:24278 ! glucoside property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:609827 name: L-canavanine namespace: chebi_ontology alt_id: CHEBI:3345 alt_id: CHEBI:42902 alt_id: CHEBI:616834 def: "An L-alpha-amino acid that is L-homoserine substituted at oxygen with a guanidino (carbamimidamido) group. Although structurally related to L-arginine, it is non-proteinogenic." [] synonym: "2-Amino-4-(guanidinooxy)butyric acid" RELATED [ChemIDplus:] synonym: "C5H12N4O3" RELATED FORMULA [KEGG COMPOUND:] synonym: "Canavanine" RELATED [KEGG COMPOUND:] synonym: "InChI=1S/C5H12N4O3/c6-3(4(10)11)1-2-12-9-5(7)8/h3H,1-2,6H2,(H,10,11)(H4,7,8,9)/t3-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=FSBIGDSBMBYOPN-VKHMYHEASA-N" RELATED InChIKey [ChEBI:] synonym: "L-CANAVANINE" EXACT [PDBeChem:] synonym: "L-Canavanine" EXACT [KEGG COMPOUND:] synonym: "N[C@@H](CCONC(N)=N)C(O)=O" RELATED SMILES [ChEBI:] synonym: "O-((Aminoiminomethyl)amino)-L-homoserine" RELATED [ChemIDplus:] synonym: "O-carbamimidamido-L-homoserine" EXACT IUPAC_NAME [IUPAC:] xref: ChemIDplus:543-38-4 "CAS Registry Number" xref: CiteXplore:22279227 "PubMed citation" xref: CiteXplore:23671680 "PubMed citation" xref: HMDB:HMDB02706 "HMDB" xref: KEGG COMPOUND:543-38-4 "CAS Registry Number" xref: KEGG COMPOUND:C00308 "KEGG COMPOUND" xref: KNApSAcK:C00001347 "KNApSAcK" xref: MetaCyc:CANAVANINE "MetaCyc" xref: PDBeChem:GGB "PDBeChem" xref: Reaxys:1726113 "Reaxys Registry Number" xref: Wikipedia:Canavanine "Wikipedia" is_a: CHEBI:15705 ! L-alpha-amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:61050 name: alkyl hydroperoxide namespace: chebi_ontology def: "A peroxol R-OOH where the substituent R is an alkyl group." [] is_a: CHEBI:35924 ! peroxol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:61057 name: tacrolimus hydrate namespace: chebi_ontology def: "A hydrate that is the monohydrate form of tacrolimus." [] synonym: "(-)-(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone monohydrate" RELATED [ChemIDplus:] synonym: "(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone--water (1/1)" EXACT IUPAC_NAME [IUPAC:] synonym: "C44H71NO13" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C44H69NO12.H2O/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7;/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3;1H2/b25-19+,27-21+;/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+;/m0./s1" RELATED InChI [ChEBI:] synonym: "InChIKey=NWJQLQGQZSIBAF-MLAUYUEBSA-N" RELATED InChIKey [ChEBI:] synonym: "O.CO[C@@H]1C[C@@H](CC[C@H]1O)\\C=C(/C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@H]([C@H](C[C@@H](C)C\\C(C)=C\\[C@@H](CC=C)C(=O)C[C@H](O)[C@H]1C)OC)[C@H](C[C@H]2C)OC" RELATED SMILES [ChEBI:] synonym: "Prograf" RELATED BRAND_NAME [KEGG DRUG:] synonym: "Protopic" RELATED BRAND_NAME [KEGG DRUG:] synonym: "tacrolimus" RELATED [ChemIDplus:] synonym: "tacrolimus monohydrate" RELATED [ChEBI:] synonym: "tsukubaenolide hydrate" RELATED [ChemIDplus:] xref: ChemIDplus:109581-93-3 "CAS Registry Number" xref: DrugBank:DB00864 "DrugBank" xref: KEGG DRUG:109581-93-3 "CAS Registry Number" xref: KEGG DRUG:D00107 "KEGG DRUG" xref: Reaxys:6265275 "Reaxys Registry Number" is_a: CHEBI:35505 ! hydrate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:61120 name: nucleobase-containing molecular entity namespace: chebi_ontology def: "Any compound that has a nucleobase as a part." [] synonym: "nucleobase-containing compound" RELATED [SUBMITTER:] synonym: "nucleobase-containing compounds" RELATED [ChEBI:] synonym: "nucleobase-containing molecular entities" RELATED [ChEBI:] is_a: CHEBI:33833 ! heteroarene is_a: CHEBI:51143 ! nitrogen molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:61292 name: guanyl nucleotide namespace: chebi_ontology def: "A nucleotide having guanine as the base." [] synonym: "guanine nucleotide" RELATED [SUBMITTER:] is_a: CHEBI:26395 ! purine nucleotide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:61293 name: adenyl nucleotide namespace: chebi_ontology def: "A nucleotide having adenine as the base." [] synonym: "adenine nucleotide" RELATED [SUBMITTER:] is_a: CHEBI:26395 ! purine nucleotide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:61296 name: adenyl ribonucleotide namespace: chebi_ontology def: "A purine riboncleotide where adenine is the purine." [] synonym: "adenine ribonucleotide" RELATED [SUBMITTER:] is_a: CHEBI:26400 ! purine ribonucleotide is_a: CHEBI:61293 ! adenyl nucleotide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:61297 name: adenyl deoxyribonucleotide namespace: chebi_ontology def: "A purine 2'-deoxyribonucleotide where the purine is adenine." [] synonym: "adenine deoxyribonucleotide" RELATED [SUBMITTER:] is_a: CHEBI:26390 ! purine 2'-deoxyribonucleotide is_a: CHEBI:61293 ! adenyl nucleotide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:61298 name: D-glucose- and/or D-galactose-substituted mannan namespace: chebi_ontology def: "A heteroglycan in which a backbone composed of D-mannose units is substituted with D-glucose and/or D-galactose units." [] synonym: "D-glucose- and/or D-galactose-substituted mannans" RELATED [ChEBI:] synonym: "substituted mannan" RELATED [ChEBI:] synonym: "substituted mannans" RELATED [ChEBI:] is_a: CHEBI:16966 ! heteroglycan property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:61310 name: chromium ion namespace: chebi_ontology def: "An chromium atom having a net electric charge." [] is_a: CHEBI:23237 ! chromium molecular entity is_a: CHEBI:36914 ! inorganic ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:61336 name: C4-dicarboxylate namespace: chebi_ontology def: "A dicarboxylate that contains four carbon atoms." [] is_a: CHEBI:28965 ! dicarboxylic acid dianion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:61355 name: 3-hydroxy carboxylic acid namespace: chebi_ontology def: "Any hydroxy carboxylic acid which contains a hydroxy group located beta- to the carboxylic acid group." [] synonym: "3-hydroxy carboxylic acids" RELATED [ChEBI:] synonym: "beta-hydroxy carboxylic acid" RELATED [ChEBI:] synonym: "beta-hydroxy carboxylic acids" RELATED [ChEBI:] is_a: CHEBI:24669 ! hydroxy carboxylic acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:61414 name: ferrichromes namespace: chebi_ontology def: "Any member of a group of iron(III) chelates that are homodetic cyclic peptides made up of a tripeptide of glycine (or other small, neutral amino acid) and a tripeptide of an N(4)-acyl-N(4)-hydroxy-L-ornithine." [] synonym: "C24H30FeN9O12R6" RELATED FORMULA [ChEBI:] synonym: "ferrichrome" RELATED [ChEBI:] is_a: CHEBI:24613 ! homodetic cyclic peptide is_a: CHEBI:84688 ! Fe(III)-complexed hydroxamate siderophore property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:61739 name: aureobasidin A namespace: chebi_ontology def: "A cyclodepsipeptide antibiotic, which is isolated from the filamentous fungus Aureobasidium pullulans R106 and is toxic to yeast at low concentrations (0.1-0.5 ug/ml)." [] synonym: "(3R,6S,9S,12S,15S,21S,24S,29aS)-21,24-dibenzyl-15-[(2R)-butan-2-yl]-9-isobutyl-6,12,18-triisopropyl-5,11,23-trimethyl-3-[(2R)-3-methylbutan-2-yl]octadecahydro-1H,15H-pyrrolo[1,2-m][1,4,7,10,13,16,19,22,25]oxaoctaazacycloheptacosine-1,4,7,10,13,16,19,22,25-nonone" EXACT IUPAC_NAME [IUPAC:] synonym: "(3S,6S,9S,12S,15S,18S,21S,24R,27S)-12,24-bis[(2R)-butan-2-yl]-15-(2-hydroxypropan-2-yl)-4,10,16,22-tetramethyl-18-(2-methylpropyl)-3,6-bis(phenylmethyl)-9,21-di(propan-2-yl)-13-oxa-1,4,7,10,16,19,22,25-octazabicyclo[25.3.0]triacontane-2,5,8,11,14,17,20,23,26-nonone" RELATED [SUBMITTER:] synonym: "Antibiotic R106I" RELATED [ChEBI:] synonym: "basifungin" RELATED INN [ChemIDplus:] synonym: "C60H92N8O10" RELATED FORMULA [ChEBI:] synonym: "CC[C@@H](C)[C@@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2ccccc2)NC(=O)C(NC1=O)C(C)C)[C@H](C)C(C)C" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C60H92N8O10/c1-17-39(12)51-55(72)63-47(36(6)7)53(70)61-44(32-41-25-20-18-21-26-41)56(73)65(14)46(33-42-27-22-19-23-28-42)58(75)68-30-24-29-45(68)52(69)64-48(40(13)35(4)5)59(76)66(15)49(37(8)9)54(71)62-43(31-34(2)3)57(74)67(16)50(38(10)11)60(77)78-51/h18-23,25-28,34-40,43-51H,17,24,29-33H2,1-16H3,(H,61,70)(H,62,71)(H,63,72)(H,64,69)/t39-,40-,43+,44+,45+,46+,47?,48-,49+,50+,51+/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=YHSKJPXGXIYLHB-OTNPUQRPSA-N" RELATED InChIKey [ChEBI:] synonym: "N-((2R,3R)-2-hydroxy-3-methylvaleryl)-N-methyl-L-valyl-L-phenylalanyl-N-methyl-L-phenylalanyl-L-prolyl-L- alloisoleucyl-N-methyl-L-valyl-L-leucyl-3-hydroxy-N-methyl- L-valine alpha1-lactone" RELATED [ChemIDplus:] xref: SUBMITTER:127785-64-2 "CAS Registry Number" is_a: CHEBI:25903 ! peptide antibiotic is_a: CHEBI:35213 ! cyclodepsipeptide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:61747 name: 4,6-O-[(1R)-1-carboxyethylidene]-D-galactose namespace: chebi_ontology def: "A monosaccharide derivative consisting of D-galactose having a 1-carboxyethylidene group masking the 4-and 6-positions." [] synonym: "4,6-O-[(1R)-1-carboxyethylidene]-D-galactopyranose" EXACT IUPAC_NAME [IUPAC:] synonym: "4,6-pyruvylated D-galactose" RELATED [ChEBI:] synonym: "C9H14O8" RELATED FORMULA [ChEBI:] synonym: "C[C@]1(OC[C@H]2OC(O)[C@H](O)[C@@H](O)[C@H]2O1)C(O)=O" RELATED SMILES [ChEBI:] synonym: "D-galactose 4,6-pyruvate acetal" RELATED [ChEBI:] synonym: "InChI=1S/C9H14O8/c1-9(8(13)14)15-2-3-6(17-9)4(10)5(11)7(12)16-3/h3-7,10-12H,2H2,1H3,(H,13,14)/t3-,4-,5-,6+,7?,9-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=QVVFNJUJKXWFAU-BTMCJACJSA-N" RELATED InChIKey [ChEBI:] xref: Reaxys:5281182 "Reaxys Registry Number" is_a: CHEBI:25384 ! monocarboxylic acid is_a: CHEBI:63367 ! monosaccharide derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:61749 name: enfumafungin namespace: chebi_ontology def: "A triterpene glycoside and hemiacetal isolated from a fermentation of Hormonema sp. and which specifically inhibits glucan synthesis in fungal cells." [] synonym: "(1S,2R,3R,4aR,6aS,7R,8R,10aR,10bR,12aS)-3-acetoxy-2-(beta-D-glucopyranosyloxy)-13-hydroxy-1,6a,8,10a-tetramethyl-8-[(2R)-3-methylbutan-2-yl]-1,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-2H-1,4a-(methanooxymethano)chrysene-7-carboxylic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "[H][C@]12CC[C@@]3([H])[C@@]4(C)COC(O)[C@@]3(C[C@@H](OC(C)=O)[C@@H]4O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C1=CC[C@@]1(C)[C@H](C(O)=O)[C@](C)(CC[C@]21C)[C@H](C)C(C)C" RELATED SMILES [ChEBI:] synonym: "C38H60O12" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C38H60O12/c1-18(2)19(3)34(5)13-14-36(7)21-9-10-25-35(6)17-47-33(46)38(25,22(21)11-12-37(36,8)29(34)31(44)45)15-23(48-20(4)40)30(35)50-32-28(43)27(42)26(41)24(16-39)49-32/h11,18-19,21,23-30,32-33,39,41-43,46H,9-10,12-17H2,1-8H3,(H,44,45)/t19-,21+,23-,24-,25+,26-,27+,28-,29-,30+,32+,33?,34-,35-,36-,37+,38+/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=IAOFPTKYKOAKGZ-CRWQHXLTSA-N" RELATED InChIKey [ChEBI:] xref: SUBMITTER:10639364 "PubMed citation" is_a: CHEBI:38131 ! lactol is_a: CHEBI:61778 ! triterpenoid saponin is_a: CHEBI:63367 ! monosaccharide derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:61777 name: terpene glycoside namespace: chebi_ontology def: "A terpenoid in which one or more hydroxy functions are glycosylated." [] synonym: "terpene glycosides" RELATED [ChEBI:] is_a: CHEBI:24400 ! glycoside is_a: CHEBI:26873 ! terpenoid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:61778 name: triterpenoid saponin namespace: chebi_ontology def: "A terpene glycoside in which the terpene moiety is a triterpenoid." [] synonym: "triterpene glycoside" RELATED [ChEBI:] synonym: "triterpene glycosides" RELATED [ChEBI:] synonym: "triterpenoid saponins" RELATED [ChEBI:] xref: Wikipedia:Triterpenoid_saponin "Wikipedia" is_a: CHEBI:26605 ! saponin is_a: CHEBI:61777 ! terpene glycoside property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:61951 name: microtubule-destabilising agent namespace: chebi_ontology def: "Any substance that interacts with tubulin to inhibit polymerisation of microtubules." [] synonym: "microtubule destabilising agent" RELATED [ChEBI:] synonym: "microtubule destabilising agents" RELATED [ChEBI:] synonym: "microtubule destabilising role" RELATED [ChEBI:] synonym: "microtubule destabilizing role" RELATED [SUBMITTER:] synonym: "microtubule-destabilising agents" RELATED [ChEBI:] synonym: "microtubule-destabilizing agent" RELATED [ChEBI:] synonym: "microtubule-destabilizing agents" RELATED [ChEBI:] xref: CiteXplore:17099073 "PubMed citation" is_a: CHEBI:60832 ! tubulin modulator is_a: CHEBI:64911 ! antimitotic property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:6198 name: (S)-azetidine-2-carboxylic acid namespace: chebi_ontology def: "The (S)-enantiomer of azetidine-2-carboxylic acid." [] synonym: "(2S)-azetidine-2-carboxylic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "(S)-(-)-Azetidine-2-carboxylic acid" RELATED [KEGG COMPOUND:] synonym: "(S)-2-azetidinecarboxylic acid" RELATED [ChemIDplus:] synonym: "(S)-azetidine-2-carboxylic acid" EXACT [ChemIDplus:] synonym: "[H][C@]1(CCN1)C(O)=O" RELATED SMILES [ChEBI:] synonym: "Azetidyl-2-carboxylic acid" RELATED [KEGG COMPOUND:] synonym: "C4H7NO2" RELATED FORMULA [KEGG COMPOUND:] synonym: "InChI=1S/C4H7NO2/c6-4(7)3-1-2-5-3/h3,5H,1-2H2,(H,6,7)/t3-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=IADUEWIQBXOCDZ-VKHMYHEASA-N" RELATED InChIKey [ChEBI:] synonym: "L-Azetidine 2-carboxylic acid" RELATED [KEGG COMPOUND:] xref: Beilstein:3648544 "Beilstein Registry Number" xref: Beilstein:80678 "Beilstein Registry Number" xref: ChemIDplus:2133-34-8 "CAS Registry Number" xref: CiteXplore:1101962 "PubMed citation" xref: CiteXplore:5041194 "PubMed citation" xref: KEGG COMPOUND:2133-34-8 "CAS Registry Number" xref: KEGG COMPOUND:C08267 "KEGG COMPOUND" xref: KNApSAcK:C00001343 "KNApSAcK" xref: Reaxys:80678 "Reaxys Registry Number" is_a: CHEBI:38108 ! azetidine-2-carboxylic acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:62733 name: aromatic amide namespace: chebi_ontology def: "An amide in which the amide linkage is bonded directly to an aromatic system." [] synonym: "aromatic amides" RELATED [ChEBI:] is_a: CHEBI:32988 ! amide is_a: CHEBI:33659 ! organic aromatic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:62764 name: reactive nitrogen species namespace: chebi_ontology def: "A family of nitrogen molecular entities which are highly reactive and derived from nitric oxide (.NO) and superoxide (O2.(-)) produced via the enzymatic activity of inducible nitric oxide synthase 2 (NOS2) and NADPH oxidase respectively." [] synonym: "RNI" RELATED [SUBMITTER:] synonym: "RNS" RELATED [SUBMITTER:] xref: SUBMITTER:12076975 "PubMed citation" xref: SUBMITTER:17667957 "PubMed citation" xref: SUBMITTER:9741578 "PubMed citation" xref: Wikipedia:Reactive nitrogen species "Wikipedia" is_a: CHEBI:51143 ! nitrogen molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:63062 name: aluminium cation namespace: chebi_ontology def: "An aluminium atom having a positive net electric charge." [] synonym: "Al cation" RELATED [ChEBI:] synonym: "Al cations" RELATED [ChEBI:] synonym: "aluminium cations" RELATED [ChEBI:] is_a: CHEBI:25213 ! metal cation is_a: CHEBI:60272 ! aluminium ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:63063 name: cadmium cation namespace: chebi_ontology def: "A transition element cation where the metal is specifed as cadmium." [] synonym: "cadmium cations" RELATED [ChEBI:] is_a: CHEBI:33515 ! transition element cation property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:63161 name: glycosyl compound namespace: chebi_ontology def: "A carbohydrate derivative arising formally from the elimination of water from a glycosidic hydroxy group and an H atom bound to an oxygen, carbon, nitrogen or sulfur atom of a separate entity." [] synonym: "glycosyl compounds" RELATED [ChEBI:] is_a: CHEBI:63299 ! carbohydrate derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:63299 name: carbohydrate derivative namespace: chebi_ontology def: "Any organooxygen compound derived from a carbohydrate by replacement of one or more hydroxy group(s) by an amino group, a thiol group or similar heteroatomic groups. The term also includes derivatives of these compounds." [] synonym: "carbohydrate derivatives" RELATED [ChEBI:] synonym: "derivatised carbohydrate" RELATED [ChEBI:] synonym: "derivatised carbohydrates" RELATED [ChEBI:] synonym: "derivatized carbohydrate" RELATED [ChEBI:] synonym: "derivatized carbohydrates" RELATED [ChEBI:] is_a: CHEBI:78616 ! carbohydrates and carbohydrate derivatives property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:63353 name: disaccharide derivative namespace: chebi_ontology def: "A carbohydrate derivative that is formally obtained from a disaccharide." [] synonym: "disaccharide derivatives" RELATED [ChEBI:] is_a: CHEBI:63299 ! carbohydrate derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:63367 name: monosaccharide derivative namespace: chebi_ontology def: "A carbohydrate derivative that is formally obtained from a monosaccharide." [] synonym: "monosaccharide derivatives" RELATED [ChEBI:] is_a: CHEBI:63299 ! carbohydrate derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:63409 name: pentose derivative namespace: chebi_ontology def: "A monosaccharide derivative that is formally obtained from a pentose." [] synonym: "pentose derivatives" RELATED [ChEBI:] is_a: CHEBI:63367 ! monosaccharide derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:63551 name: carbohydrate acid derivative anion namespace: chebi_ontology def: "A carboxylic acid anion resulting from the deprotonation of the carboxy group of a carbohydrate acid derivative." [] synonym: "carbohydrate acid anion derivative" RELATED [ChEBI:] synonym: "carbohydrate acid anion derivatives" RELATED [ChEBI:] synonym: "carbohydrate acid derivative anions" RELATED [ChEBI:] is_a: CHEBI:29067 ! carboxylic acid anion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:63563 name: oligosaccharide derivative namespace: chebi_ontology def: "A carbohydrate derivative that is formally obtained from an oligosaccharide." [] synonym: "O-glycosylglycoside derivative" RELATED [ChEBI:] synonym: "O-glycosylglycoside derivatives" RELATED [ChEBI:] synonym: "oligosaccharide derivatives" RELATED [ChEBI:] is_a: CHEBI:63299 ! carbohydrate derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:63573 name: guanyl deoxyribonucleotide namespace: chebi_ontology def: "A purine 2'-deoxyribonucleotide where the purine is guanine." [] synonym: "guanine 2'-deoxyribonucleotide" RELATED [ChEBI:] synonym: "guanine deoxyribonucleotide" RELATED [ChEBI:] synonym: "guanyl 2'-deoxyribonucleotide" RELATED [ChEBI:] xref: CiteXplore:10470363 "PubMed citation" is_a: CHEBI:26390 ! purine 2'-deoxyribonucleotide is_a: CHEBI:61292 ! guanyl nucleotide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:63618 name: pravastatin namespace: chebi_ontology alt_id: CHEBI:8360 def: "A carboxylic ester resulting from the formal condensation of (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin." [] synonym: "(+)-(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(S)-2-methylbutyryl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthyl]heptanoic acid" RELATED [ChEBI:] synonym: "(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "[H][C@]12[C@H](C[C@H](O)C=C1C=C[C@H](C)[C@@H]2CC[C@@H](O)C[C@@H](O)CC(O)=O)OC(=O)[C@@H](C)CC" RELATED SMILES [ChEBI:] synonym: "C23H36O7" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C23H36O7/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28)/t13-,14-,16+,17+,18+,19-,20-,22-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=TUZYXOIXSAXUGO-PZAWKZKUSA-N" RELATED InChIKey [ChEBI:] synonym: "Pravastatin" EXACT [KEGG COMPOUND:] synonym: "pravastatin" RELATED INN [ChemIDplus:] synonym: "pravastatin acid" RELATED [ChEBI:] synonym: "pravastatina" RELATED INN [ChemIDplus:] synonym: "pravastatine" RELATED INN [ChemIDplus:] synonym: "pravastatinum" RELATED INN [ChemIDplus:] xref: ChemIDplus:81093-37-0 "CAS Registry Number" xref: CiteXplore:21749370 "PubMed citation" xref: CiteXplore:21851379 "PubMed citation" xref: CiteXplore:25264019 "PubMed citation" xref: DrugBank:DB00175 "DrugBank" xref: HMDB:HMDB05022 "HMDB" xref: KEGG COMPOUND:81093-37-0 "CAS Registry Number" xref: KEGG COMPOUND:C01844 "KEGG COMPOUND" xref: KEGG DRUG:D08410 "KEGG DRUG" xref: KNApSAcK:C00000565 "KNApSAcK" xref: Reaxys:4825538 "Reaxys Registry Number" xref: Wikipedia:Pravastatin "Wikipedia" is_a: CHEBI:33308 ! carboxylic ester is_a: CHEBI:35681 ! secondary alcohol is_a: CHEBI:35868 ! hydroxy monocarboxylic acid is_a: CHEBI:36785 ! carbobicyclic compound is_a: CHEBI:61355 ! 3-hydroxy carboxylic acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:63944 name: macrocyclic lactone namespace: chebi_ontology alt_id: CHEBI:50333 def: "Any lactone in which the cyclic carboxylic ester group forms a part of a cyclic macromolecule." [] synonym: "macrocyclic lactones" RELATED [ChEBI:] is_a: CHEBI:25000 ! lactone is_a: CHEBI:51026 ! macrocycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:63945 name: ferrozine(2-) namespace: chebi_ontology def: "An organosulfonate oxoanion obtained by deprotonation of the sulfo groups of 4,4'-[3-(pyridin-2-yl)-1,2,4-triazine-5,6-diyl]dibenzenesulfonic acid." [] synonym: "4,4'-[3-(pyridin-2-yl)-1,2,4-triazine-5,6-diyl]dibenzenesulfonate" EXACT IUPAC_NAME [IUPAC:] synonym: "[O-]S(=O)(=O)c1ccc(cc1)-c1nnc(nc1-c1ccc(cc1)S([O-])(=O)=O)-c1ccccn1" RELATED SMILES [ChEBI:] synonym: "C20H12N4O6S2" RELATED FORMULA [ChEBI:] synonym: "ferrozine cation" RELATED [ChEBI:] synonym: "InChI=1S/C20H14N4O6S2/c25-31(26,27)15-8-4-13(5-9-15)18-19(14-6-10-16(11-7-14)32(28,29)30)23-24-20(22-18)17-3-1-2-12-21-17/h1-12H,(H,25,26,27)(H,28,29,30)/p-2" RELATED InChI [ChEBI:] synonym: "InChIKey=JFVUMQYWYNDZDK-UHFFFAOYSA-L" RELATED InChIKey [ChEBI:] xref: Reaxys:19533553 "Reaxys Registry Number" is_a: CHEBI:33554 ! organosulfonate oxoanion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:64090 name: tert-butyl hydroperoxide namespace: chebi_ontology def: "An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes." [] synonym: "1,1-Dimethylethyl hydroperoxide" RELATED [ChemIDplus:] synonym: "2-Hydroperoxy-2-methylpropane" RELATED [ChemIDplus:] synonym: "C4H10O2" RELATED FORMULA [ChEBI:] synonym: "CC(C)(C)OO" RELATED SMILES [ChEBI:] synonym: "Dimethylethyl hydroperoxide" RELATED [NIST Chemistry WebBook:] synonym: "Hydroperoxyde de butyle tertiaire" RELATED [NIST Chemistry WebBook:] synonym: "InChI=1S/C4H10O2/c1-4(2,3)6-5/h5H,1-3H3" RELATED InChI [ChEBI:] synonym: "InChIKey=CIHOLLKRGTVIJN-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "t-butyl hydroperoxide" RELATED [ChEBI:] synonym: "t-Butylhydroperoxide" RELATED [NIST Chemistry WebBook:] synonym: "TBHP" RELATED [ChEBI:] synonym: "tert-butyl hydroperoxide" EXACT IUPAC_NAME [IUPAC:] synonym: "tert-Butylhydroperoxide" RELATED [ChemIDplus:] synonym: "Tertiary-butyl hydroperoxide" RELATED [NIST Chemistry WebBook:] xref: ChemIDplus:1098280 "Beilstein Registry Number" xref: ChemIDplus:75-91-2 "CAS Registry Number" xref: CiteXplore:21418283 "PubMed citation" xref: CiteXplore:22037478 "PubMed citation" xref: CiteXplore:22039964 "PubMed citation" xref: CiteXplore:22326806 "PubMed citation" xref: CiteXplore:22337620 "PubMed citation" xref: CiteXplore:22369679 "PubMed citation" xref: NIST Chemistry WebBook:75-91-2 "CAS Registry Number" xref: Reaxys:1098280 "Reaxys Registry Number" xref: Wikipedia:Tert-Butyl_hydroperoxide "Wikipedia" is_a: CHEBI:61050 ! alkyl hydroperoxide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:64103 name: sodium butyrate namespace: chebi_ontology def: "An organic sodium salt resulting from the replacement of the proton from the carboxy group of butyric acid by a sodium ion." [] synonym: "[Na+].CCCC([O-])=O" RELATED SMILES [ChEBI:] synonym: "Butanoic acid, sodium salt" RELATED [ChemIDplus:] synonym: "Butanoic acid, sodium salt (1:1)" RELATED [ChemIDplus:] synonym: "Butyrate sodium" RELATED [ChemIDplus:] synonym: "Butyric acid sodium salt" RELATED [ChemIDplus:] synonym: "Butyric acid, sodium salt" RELATED [ChemIDplus:] synonym: "C4H7NaO2" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1" RELATED InChI [ChEBI:] synonym: "InChIKey=MFBOGIVSZKQAPD-UHFFFAOYSA-M" RELATED InChIKey [ChEBI:] synonym: "sodium butanoate" EXACT IUPAC_NAME [IUPAC:] synonym: "Sodium n-butyrate" RELATED [ChemIDplus:] synonym: "Sodium propanecarboxylate" RELATED [ChemIDplus:] xref: ChemIDplus:156-54-7 "CAS Registry Number" xref: CiteXplore:12840228 "PubMed citation" xref: CiteXplore:21593570 "PubMed citation" xref: CiteXplore:21699495 "PubMed citation" xref: CiteXplore:21947091 "PubMed citation" xref: CiteXplore:21984169 "PubMed citation" xref: CiteXplore:22024383 "PubMed citation" xref: CiteXplore:22067609 "PubMed citation" xref: CiteXplore:22160140 "PubMed citation" xref: CiteXplore:22228088 "PubMed citation" xref: CiteXplore:22246241 "PubMed citation" xref: CiteXplore:22253909 "PubMed citation" xref: CiteXplore:22273669 "PubMed citation" xref: CiteXplore:22288569 "PubMed citation" xref: CiteXplore:22293191 "PubMed citation" xref: CiteXplore:22338096 "PubMed citation" xref: CiteXplore:22353286 "PubMed citation" xref: CiteXplore:22381755 "PubMed citation" xref: NIST Chemistry WebBook:156-54-7 "CAS Registry Number" xref: Reaxys:3629439 "Reaxys Registry Number" xref: Wikipedia:Sodium_butyrate "Wikipedia" is_a: CHEBI:38700 ! organic sodium salt property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:64110 name: 4,4',4''-(4-propylpyrazole-1,3,5-triyl)trisphenol namespace: chebi_ontology def: "A pyrazole that is 1H-pyrazole bearing three 4-hydroxyphenyl substituents at positions 1, 3 and 5 as well as a propyl substituent at position 4. Potent, subtype-selective estrogen receptor agonist (EC50 ~ 200 pM); displays 410-fold selectivity for ERalpha over ERbeta. Prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo." [] synonym: "1,3,5-tris(4-hydroxyphenyl)-4-propylpyrazole" RELATED [ChEBI:] synonym: "4,4',4''-(4-propyl-1H-pyrazole-1,3,5-triyl)triphenol" EXACT IUPAC_NAME [IUPAC:] synonym: "C24H22N2O3" RELATED FORMULA [ChEBI:] synonym: "CCCc1c(nn(-c2ccc(O)cc2)c1-c1ccc(O)cc1)-c1ccc(O)cc1" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C24H22N2O3/c1-2-3-22-23(16-4-10-19(27)11-5-16)25-26(18-8-14-21(29)15-9-18)24(22)17-6-12-20(28)13-7-17/h4-15,27-29H,2-3H2,1H3" RELATED InChI [ChEBI:] synonym: "InChIKey=IOTXSIGGFRQYKW-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] xref: Reaxys:8798122 "Reaxys Registry Number" is_a: CHEBI:26410 ! pyrazoles is_a: CHEBI:33853 ! phenols property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:64120 name: M-factor namespace: chebi_ontology def: "A nine-membered oligopeptide that consists of tyrosyl, threonyl, prolyl, lysyl, valyl, prolyl, tyrosyl, methionyl and methyl S-farnesylcysteinate residues joined in sequence. A peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Minus." [] synonym: "C67H102N10O13S2" RELATED FORMULA [ChEBI:] synonym: "COC(=O)[C@H](CSC\\C=C(/C)CC\\C=C(/C)CCC=C(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)O)C(C)C" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C67H102N10O13S2/c1-41(2)16-12-17-43(5)18-13-19-44(6)31-37-92-40-54(67(89)90-8)73-60(82)52(32-36-91-9)70-62(84)53(39-47-25-29-49(80)30-26-47)72-64(86)56-22-14-34-76(56)65(87)57(42(3)4)74-61(83)51(20-10-11-33-68)71-63(85)55-21-15-35-77(55)66(88)58(45(7)78)75-59(81)50(69)38-46-23-27-48(79)28-24-46/h16,18,23-31,42,45,50-58,78-80H,10-15,17,19-22,32-40,68-69H2,1-9H3,(H,70,84)(H,71,85)(H,72,86)(H,73,82)(H,74,83)(H,75,81)/b43-18+,44-31+/t45-,50+,51+,52+,53+,54+,55+,56+,57+,58+/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=YDFHVOKEEMMIBE-RDJQXTLESA-N" RELATED InChIKey [ChEBI:] synonym: "methyl L-tyrosyl-L-threonyl-L-prolyl-L-lysyl-L-valyl-L-prolyl-L-tyrosyl-L-methionyl-S-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]-L-cysteinate" EXACT IUPAC_NAME [IUPAC:] synonym: "Tyr-Thr-Pro-Lys-Val-Pro-Tyr-Met-Cys(Far)OCH3" RELATED [ChEBI:] synonym: "Tyr-Thr-Pro-Lys-Val-Pro-Tyr-Met-Cys(Far)OMe" RELATED [ChEBI:] synonym: "Tyr-Thr-Pro-Lys-Val-Pro-Tyr-Met-Cys(S-farnesyl)-OCH3" RELATED [ChEBI:] synonym: "Tyr-Thr-Pro-Lys-Val-Pro-Tyr-Met-Cys(S-farnesyl)-OMe" RELATED [ChEBI:] synonym: "YTPKVPYMC(Far)OMe" RELATED [ChEBI:] xref: SUBMITTER:7941744 "PubMed citation" is_a: CHEBI:25676 ! oligopeptide is_a: CHEBI:38579 ! peptide pheromone property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:64121 name: P-factor namespace: chebi_ontology def: "A polypeptide of 23 residues, with the sequence Thr-Tyr-Ala-Asp-Phe-Leu-Arg-Ala-Tyr-Gln-Ser-Trp-Asn-Thr-Phe-Val-Asn-Pro-Asp-Arg-Pro-Asn-Leu. A peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Plus." [] synonym: "C128H182N34O37" RELATED FORMULA [ChEBI:] synonym: "CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)[C@@H](C)O)[C@@H](C)O)C(C)C)C(O)=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C128H182N34O37/c1-61(2)47-80(148-111(183)83(49-68-23-13-11-14-24-68)149-115(187)88(57-99(172)173)147-105(177)65(8)142-108(180)81(154-121(193)101(133)66(9)164)51-70-33-37-73(166)38-34-70)109(181)143-77(29-19-43-138-127(134)135)106(178)141-64(7)104(176)146-82(52-71-35-39-74(167)40-36-71)110(182)144-78(41-42-95(129)168)107(179)158-92(60-163)118(190)150-85(53-72-59-140-76-28-18-17-27-75(72)76)112(184)151-87(55-97(131)170)117(189)160-103(67(10)165)123(195)155-84(50-69-25-15-12-16-26-69)116(188)159-102(63(5)6)122(194)156-90(56-98(132)171)125(197)162-46-22-32-94(162)120(192)153-89(58-100(174)175)114(186)145-79(30-20-44-139-128(136)137)124(196)161-45-21-31-93(161)119(191)152-86(54-96(130)169)113(185)157-91(126(198)199)48-62(3)4/h11-18,23-28,33-40,59,61-67,77-94,101-103,140,163-167H,19-22,29-32,41-58,60,133H2,1-10H3,(H2,129,168)(H2,130,169)(H2,131,170)(H2,132,171)(H,141,178)(H,142,180)(H,143,181)(H,144,182)(H,145,186)(H,146,176)(H,147,177)(H,148,183)(H,149,187)(H,150,190)(H,151,184)(H,152,191)(H,153,192)(H,154,193)(H,155,195)(H,156,194)(H,157,185)(H,158,179)(H,159,188)(H,160,189)(H,172,173)(H,174,175)(H,198,199)(H4,134,135,138)(H4,136,137,139)/t64-,65-,66+,67+,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,101-,102-,103-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=LUNBMBVWKORSGN-TYEKWLQESA-N" RELATED InChIKey [ChEBI:] synonym: "L-threonyl-L-tyrosyl-L-alanyl-L-alpha-aspartyl-L-phenylalanyl-L-leucyl-L-arginyl-L-alanyl-L-tyrosyl-L-glutaminyl-L-seryl-L-tryptophyl-L-asparaginyl-L-threonyl-L-phenylalanyl-L-valyl-L-asparaginyl-L-prolyl-L-alpha-aspartyl-L-arginyl-L-prolyl-L-asparaginyl-L-leucine" EXACT IUPAC_NAME [IUPAC:] synonym: "Thr-Tyr-Ala-Asp-Phe-Leu-Arg-Ala-Tyr-Gln-Ser-Trp-Asn-Thr-Phe-Val-Asn-Pro-Asp-Arg-Pro-Asn-Leu" EXACT IUPAC_NAME [IUPAC:] synonym: "TYADFLRAYQSWNTFVNPARPNL" EXACT IUPAC_NAME [IUPAC:] xref: SUBMITTER:8314086 "PubMed citation" is_a: CHEBI:15841 ! polypeptide is_a: CHEBI:25905 ! peptide hormone is_a: CHEBI:33694 ! biomacromolecule property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:64641 name: divalent inorganic cation namespace: chebi_ontology def: "An inorganic cation with a valency of two." [] is_a: CHEBI:36915 ! inorganic cation property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:64708 name: one-carbon compound namespace: chebi_ontology def: "An organic molecular entity containing a single carbon atom (C1)." [] synonym: "one-carbon compounds" RELATED [ChEBI:] is_a: CHEBI:50860 ! organic molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:64709 name: organic acid namespace: chebi_ontology def: "Any organic molecular entity that is acidic and contains carbon in covalent linkage." [] synonym: "organic acids" RELATED [ChEBI:] is_a: CHEBI:50860 ! organic molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:64911 name: antimitotic namespace: chebi_ontology def: "Any compound that inhibits cell division (mitosis)." [] synonym: "antimitotics" RELATED [ChEBI:] synonym: "mitosis inhibitor" RELATED [ChEBI:] synonym: "mitosis inhibitors" RELATED [ChEBI:] synonym: "mitotic inhibitor" RELATED [ChEBI:] synonym: "mitotic inhibitors" RELATED [ChEBI:] xref: Wikipedia:Mitotic_inhibitor "Wikipedia" is_a: CHEBI:52210 ! pharmacological role property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:65212 name: polysaccharide derivative namespace: chebi_ontology def: "A carbohydrate derivative that is any derivative of a polysaccharide." [] synonym: "polysaccharide derivatives" RELATED [ChEBI:] is_a: CHEBI:33694 ! biomacromolecule is_a: CHEBI:63299 ! carbohydrate derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:65915 name: FR901464 namespace: chebi_ontology def: "An oxaspiro compound with potent anticancer activity that lowers the mRNA levels of oncogenes and tumour supressor genes. It is isolated from Pseudomonas sp. no.2663." [] synonym: "(2S,3Z)-5-{[(2R,3R,5S,6S)-6-{(2E,4E)-5-[(3R,4R,5R,7S)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]oct-5-yl]-3-methylpenta-2,4-dien-1-yl}-2,5-dimethyltetrahydro-2H-pyran-3-yl]amino}-5-oxopent-3-en-2-yl acetate" EXACT IUPAC_NAME [IUPAC:] synonym: "C27H41NO8" RELATED FORMULA [ChEBI:] synonym: "C[C@H]1C[C@@H](NC(=O)\\C=C/[C@H](C)OC(C)=O)[C@@H](C)O[C@H]1C\\C=C(C)\\C=C\\[C@H]1O[C@](C)(O)C[C@@]2(CO2)[C@@H]1O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C27H41NO8/c1-16(8-11-23-25(31)27(15-33-27)14-26(6,32)36-23)7-10-22-17(2)13-21(19(4)35-22)28-24(30)12-9-18(3)34-20(5)29/h7-9,11-12,17-19,21-23,25,31-32H,10,13-15H2,1-6H3,(H,28,30)/b11-8+,12-9-,16-7+/t17-,18-,19+,21+,22-,23+,25+,26-,27+/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=PJKVJJDQXZARCA-QHYZBLTGSA-N" RELATED InChIKey [ChEBI:] xref: ChemIDplus:146478-72-0 "CAS Registry Number" xref: CiteXplore:17279752 "PubMed citation" xref: CiteXplore:21226105 "PubMed citation" xref: CiteXplore:9031664 "PubMed citation" xref: Patent:US2011086909 "Patent" xref: Patent:WO2009031999 "Patent" xref: Reaxys:8176008 "Reaxys Registry Number" is_a: CHEBI:26407 ! pyrans is_a: CHEBI:29347 ! monocarboxylic acid amide is_a: CHEBI:32955 ! epoxide is_a: CHEBI:37948 ! oxaspiro compound is_a: CHEBI:47622 ! acetate ester is_a: CHEBI:59780 ! cyclic hemiketal property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:67142 name: nucleobase analogue namespace: chebi_ontology def: "A molecule that can substitute for a normal nucleobase in nucleic acids." [] synonym: "base analog" RELATED [ChEBI:] synonym: "base analogs" RELATED [ChEBI:] synonym: "base analogue" RELATED [ChEBI:] synonym: "base analogues" RELATED [ChEBI:] synonym: "nucleobase analog" RELATED [ChEBI:] synonym: "nucleobase analogs" RELATED [ChEBI:] synonym: "nucleobase analogues" RELATED [ChEBI:] xref: Wikipedia:Base_analog "Wikipedia" is_a: CHEBI:33832 ! organic cyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:67202 name: N,N'-(p-xylylidene)bis(aminoguanidine) dihydrochloride namespace: chebi_ontology def: "The hydrochloride salt of N,N'-(p-xylylidene)bis(aminoguanidine) [ratio HCl : N,N'-(p-xylylidene)bis(aminoguanidine) = 2:1]." [] synonym: "1,1'-(p-Phenylenebis(methylidynenitrilo))diguanidine dihydrochloride" RELATED [ChemIDplus:] synonym: "C10H16Cl2N8" RELATED FORMULA [ChEBI:] synonym: "Cl.Cl.[H]C(=NN=C(N)N)c1ccc(cc1)C([H])=NN=C(N)N" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C10H14N8.2ClH/c11-9(12)17-15-5-7-1-2-8(4-3-7)6-16-18-10(13)14;;/h1-6H,(H4,11,12,17)(H4,13,14,18);2*1H" RELATED InChI [ChEBI:] synonym: "InChIKey=CWHXFFQCOLGJFG-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "N'',N'''''-(1,4-phenylenedimethylylidene)dicarbonohydrazonic diamide dihydrochloride" EXACT IUPAC_NAME [IUPAC:] synonym: "N,N-(p-Xylylidene)bisaminoguanidine dihydrochloride" RELATED [ChemIDplus:] xref: ChemIDplus:7044-24-8 "CAS Registry Number" is_a: CHEBI:36807 ! hydrochloride property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:68452 name: azole namespace: chebi_ontology def: "Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen." [] synonym: "azoles" RELATED [ChEBI:] xref: Wikipedia:Azole "Wikipedia" is_a: CHEBI:38101 ! organonitrogen heterocyclic compound is_a: CHEBI:38179 ! monocyclic heteroarene property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:68508 name: diethyl maleate namespace: chebi_ontology def: "A maleate ester resulting from the formal condensation of both carboxy groups of maleic acid with ethanol. A colourless liquid at room temperature (m.p. -10degreeC) with boiling point 220degreeC at 1 atm., it is commonly used as a dienophile for Diels-Alder-type cycloaddition reactions in organic synthesis." [] synonym: "2-butenedioic acid (2Z)-, dimethyl ester" RELATED [ChemIDplus:] synonym: "C8H12O4" RELATED FORMULA [ChEBI:] synonym: "CCOC(=O)\\C=C/C(=O)OCC" RELATED SMILES [ChEBI:] synonym: "diethyl (2Z)-but-2-enedioate" EXACT IUPAC_NAME [IUPAC:] synonym: "InChI=1S/C8H12O4/c1-3-11-7(9)5-6-8(10)12-4-2/h5-6H,3-4H2,1-2H3/b6-5-" RELATED InChI [ChEBI:] synonym: "InChIKey=IEPRKVQEAMIZSS-WAYWQWQTSA-N" RELATED InChIKey [ChEBI:] synonym: "maleic acid, diethyl ester" RELATED [NIST Chemistry WebBook:] xref: ChemIDplus:141-05-9 "CAS Registry Number" xref: CiteXplore:1471155 "PubMed citation" xref: CiteXplore:1609410 "PubMed citation" xref: CiteXplore:3341033 "PubMed citation" xref: NIST Chemistry WebBook:141-05-9 "CAS Registry Number" xref: Reaxys:907616 "Reaxys Registry Number" is_a: CHEBI:35486 ! maleate ester property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:68662 name: S-ethylhomocysteine namespace: chebi_ontology def: "An alpha-amino acid that is methionine in which the S-methyl group is replaced by an S-ethyl group." [] synonym: "2-amino-4-(ethylsulfanyl)butanoic acid" RELATED [IUPAC:] synonym: "C6H13NO2S" RELATED FORMULA [ChEBI:] synonym: "CCSCCC(N)C(O)=O" RELATED SMILES [ChEBI:] synonym: "ethionine" RELATED [ChEBI:] synonym: "InChI=1S/C6H13NO2S/c1-2-10-4-3-5(7)6(8)9/h5H,2-4,7H2,1H3,(H,8,9)" RELATED InChI [ChEBI:] synonym: "InChIKey=GGLZPLKKBSSKCX-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "S-ethylhomocysteine" EXACT IUPAC_NAME [IUPAC:] xref: ChemIDplus:67-21-0 "CAS Registry Number" xref: CiteXplore:23867992 "PubMed citation" xref: CiteXplore:6030278 "PubMed citation" xref: CiteXplore:6744518 "PubMed citation" xref: Reaxys:1722529 "Reaxys Registry Number" is_a: CHEBI:16385 ! organic sulfide is_a: CHEBI:25384 ! monocarboxylic acid is_a: CHEBI:33704 ! alpha-amino acid is_a: CHEBI:50994 ! primary amino compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:69136 name: latrunculin A namespace: chebi_ontology alt_id: CHEBI:43626 def: "A bicyclic macrolide natural product consisting of a 16-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica and from the Fiji Islands sponge Cacospongia mycofijiensis. Latrunculin A inhibits actin polymerisation, microfilament organsation and microfilament-mediated processes." [] synonym: "(+)-latrunculin A" RELATED [ChEBI:] synonym: "(4R)-4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-1,3-thiazolidin-2-one" EXACT IUPAC_NAME [IUPAC:] synonym: "(4R)-4-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-1,3-thiazolidin-2-one" RELATED [PDBeChem:] synonym: "2-Thiazolidinone, 4-((1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo(13.3.1)nonadeca-4,8,10-trien-17-yl)-, (4R)-" RELATED [ChEBI:] synonym: "[H][C@]1(CSC(=O)N1)[C@@]1(O)C[C@H]2C[C@@H](CC[C@H](C)\\C=C/C=C/CC\\C(C)=C/C(=O)O2)O1" RELATED SMILES [ChEBI:] synonym: "C22H31NO5S" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C22H31NO5S/c1-15-7-5-3-4-6-8-16(2)11-20(24)27-18-12-17(10-9-15)28-22(26,13-18)19-14-29-21(25)23-19/h3-5,7,11,15,17-19,26H,6,8-10,12-14H2,1-2H3,(H,23,25)/b4-3+,7-5-,16-11-/t15-,17-,18-,19+,22-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=DDVBPZROPPMBLW-IZGXTMSKSA-N" RELATED InChIKey [ChEBI:] synonym: "LAT-A" RELATED [ChemIDplus:] synonym: "LatA" RELATED [ChEBI:] synonym: "LATRUNCULIN A" EXACT [PDBeChem:] synonym: "NSC 613011" RELATED [ChemIDplus:] xref: ChemIDplus:76343-93-6 "CAS Registry Number" xref: CiteXplore:10859320 "PubMed citation" xref: CiteXplore:12087066 "PubMed citation" xref: CiteXplore:17897856 "PubMed citation" xref: CiteXplore:19528469 "PubMed citation" xref: CiteXplore:20677927 "PubMed citation" xref: CiteXplore:22129061 "PubMed citation" xref: CiteXplore:22492972 "PubMed citation" xref: CiteXplore:22498812 "PubMed citation" xref: CiteXplore:3200109 "PubMed citation" xref: CiteXplore:3556584 "PubMed citation" xref: CiteXplore:9250716 "PubMed citation" xref: PDBeChem:LAR "PDBeChem" xref: Reaxys:4239363 "Reaxys Registry Number" is_a: CHEBI:25106 ! macrolide is_a: CHEBI:46733 ! oxabicycloalkane is_a: CHEBI:48891 ! thiazolidinone is_a: CHEBI:59780 ! cyclic hemiketal property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:6923 name: miconazole namespace: chebi_ontology alt_id: CHEBI:108917 def: "A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes." [] synonym: "(+-)-miconazole" RELATED [ChEBI:] synonym: "(RS)-miconazole" RELATED [ChEBI:] synonym: "1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole" RELATED [ChemIDplus:] synonym: "1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole" RELATED [ChEMBL:] synonym: "Daktarin IV" RELATED [ChemIDplus:] synonym: "Miconazole" EXACT [KEGG DRUG:] synonym: "Monistat IV (TN)" RELATED [KEGG DRUG:] synonym: "rac-1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole" EXACT IUPAC_NAME [IUPAC:] synonym: "rac-miconazole" RELATED [ChEBI:] xref: ChemIDplus:22916-47-8 "CAS Registry Number" xref: CiteXplore:11922774 "PubMed citation" xref: CiteXplore:15187422 "PubMed citation" xref: CiteXplore:15778703 "PubMed citation" xref: CiteXplore:16608920 "PubMed citation" xref: CiteXplore:24389479 "PubMed citation" xref: CiteXplore:24533891 "PubMed citation" xref: CiteXplore:24550099 "PubMed citation" xref: CiteXplore:24629000 "PubMed citation" xref: CiteXplore:24842191 "PubMed citation" xref: CiteXplore:24852893 "PubMed citation" xref: CiteXplore:24919490 "PubMed citation" xref: CiteXplore:25070654 "PubMed citation" xref: CiteXplore:25084742 "PubMed citation" xref: CiteXplore:25179092 "PubMed citation" xref: CiteXplore:8683405 "PubMed citation" xref: DrugBank:DB01110 "DrugBank" xref: KEGG DRUG:22916-47-8 "CAS Registry Number" xref: KEGG DRUG:D00416 "KEGG DRUG" xref: Reaxys:965511 "Reaxys Registry Number" xref: Wikipedia:Miconazole "Wikipedia" is_a: CHEBI:60911 ! racemate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:70723 name: reversine namespace: chebi_ontology def: "A member of the class of purines that is 9H-purine in which the hydrogens at positions 2 and 6 are replaced by a [4-(morpholin-4-yl)phenyl]nitrilo group and a cyclohexylamino group, respectively." [] synonym: "2-(4-morpholinoanilino)-6-cyclohexylaminopurine" RELATED [ChEBI:] synonym: "C1CCC(CC1)Nc1nc(Nc2ccc(cc2)N2CCOCC2)nc2[nH]cnc12" RELATED SMILES [ChEBI:] synonym: "C21H27N7O" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C21H27N7O/c1-2-4-15(5-3-1)24-20-18-19(23-14-22-18)26-21(27-20)25-16-6-8-17(9-7-16)28-10-12-29-13-11-28/h6-9,14-15H,1-5,10-13H2,(H3,22,23,24,25,26,27)" RELATED InChI [ChEBI:] synonym: "InChIKey=ZFLJHSQHILSNCM-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "N(6)-cyclohexyl-N(2)-[4-(morpholin-4-yl)phenyl]-9H-purine-2,6-diamine" EXACT IUPAC_NAME [IUPAC:] xref: ChemIDplus:656820-32-5 "CAS Registry Number" xref: CiteXplore:14719906 "PubMed citation" xref: CiteXplore:16033270 "PubMed citation" xref: CiteXplore:17258475 "PubMed citation" xref: CiteXplore:17490611 "PubMed citation" xref: CiteXplore:17566101 "PubMed citation" xref: CiteXplore:17973295 "PubMed citation" xref: CiteXplore:17982654 "PubMed citation" xref: CiteXplore:18483302 "PubMed citation" xref: CiteXplore:19947906 "PubMed citation" xref: CiteXplore:20103988 "PubMed citation" xref: CiteXplore:20624901 "PubMed citation" xref: CiteXplore:22051168 "PubMed citation" xref: CiteXplore:22283874 "PubMed citation" xref: CiteXplore:22477067 "PubMed citation" xref: CiteXplore:22592527 "PubMed citation" xref: CiteXplore:22615034 "PubMed citation" xref: CiteXplore:22821411 "PubMed citation" xref: CiteXplore:22926505 "PubMed citation" xref: Reaxys:9591952 "Reaxys Registry Number" xref: Wikipedia:Reversine "Wikipedia" is_a: CHEBI:26401 ! purines is_a: CHEBI:38785 ! morpholines is_a: CHEBI:50995 ! secondary amino compound is_a: CHEBI:50996 ! tertiary amino compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:70726 name: hesperadin namespace: chebi_ontology def: "An oxindole that is indolin-2-one which is substituted at position 5 by an (ethylsulfonyl)nitrilo group and at position 2 by a methylidene group, which is itself substituted by a phenyl group and a [4-(piperidin-1-ylmethyl)phenyl]amino group. An Aurora B kinase inhibitor, it is used to inhibit chromosome alignment and segregation." [] synonym: "C29H32N4O3S" RELATED FORMULA [ChEBI:] synonym: "CCS(=O)(=O)Nc1ccc2NC(=O)\\C(c2c1)=C(/Nc1ccc(CN2CCCCC2)cc1)c1ccccc1" RELATED SMILES [ChEBI:] synonym: "hesperadine" RELATED [ChEBI:] synonym: "InChI=1S/C29H32N4O3S/c1-2-37(35,36)32-24-15-16-26-25(19-24)27(29(34)31-26)28(22-9-5-3-6-10-22)30-23-13-11-21(12-14-23)20-33-17-7-4-8-18-33/h3,5-6,9-16,19,30,32H,2,4,7-8,17-18,20H2,1H3,(H,31,34)/b28-27-" RELATED InChI [ChEBI:] synonym: "InChIKey=GLDSKRNGVVYJAB-DQSJHHFOSA-N" RELATED InChIKey [ChEBI:] synonym: "N-[(3Z)-2-oxo-3-(phenyl{[4-(piperidin-1-ylmethyl)phenyl]amino}methylidene)-2,3-dihydro-1H-indol-5-yl]ethanesulfonamide" EXACT IUPAC_NAME [IUPAC:] xref: CiteXplore:12707311 "PubMed citation" xref: CiteXplore:15866179 "PubMed citation" xref: CiteXplore:19320832 "PubMed citation" xref: Reaxys:14118003 "Reaxys Registry Number" xref: Wikipedia:422513-13-1 "CAS Registry Number" xref: Wikipedia:Hesperadin "Wikipedia" is_a: CHEBI:26151 ! piperidines is_a: CHEBI:35358 ! sulfonamide is_a: CHEBI:38459 ! oxindole is_a: CHEBI:47989 ! enamine is_a: CHEBI:50996 ! tertiary amino compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:70727 name: topoisomerase inhibitor namespace: chebi_ontology def: "An EC 5.99.1.* (miscellaneous isomerase) inhibitor that interferes with the action of any of the topoisomerases (enzymes that regulate the overwinding or underwinding of DNA)." [] synonym: "topoisomerase inhibitors" RELATED [ChEBI:] xref: Wikipedia:Topoisomerase "Wikipedia" is_a: CHEBI:76830 ! EC 5.99.1.* (miscellaneous isomerase) inhibitor property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:70773 name: capsazepine namespace: chebi_ontology def: "A benzazepine that is 2,3,4,5-tetrahydro-1H-2-benzazepine which is substituted by hydroxy groups at positions 7 and 8 and on the nitrogen atom by a 2-(p-chlorophenyl)ethylaminothiocarbonyl group. A synthetic analogue of capsaicin, it was the first reported capsaicin receptor antagonist." [] synonym: "2-[2-(4-chlorophenyl)ethylamino-thiocarbonyl]-7,8-dihydroxy-2,3,4,5-tetrahydro-1H-2-benzazepine" RELATED [ChEBI:] synonym: "C19H21ClN2O2S" RELATED FORMULA [ChEBI:] synonym: "capsazepin" RELATED [ChEBI:] synonym: "InChI=1S/C19H21ClN2O2S/c20-16-5-3-13(4-6-16)7-8-21-19(25)22-9-1-2-14-10-17(23)18(24)11-15(14)12-22/h3-6,10-11,23-24H,1-2,7-9,12H2,(H,21,25)" RELATED InChI [ChEBI:] synonym: "InChIKey=DRCMAZOSEIMCHM-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "N-(2-[4-chlorophenyl]ethyl)-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide" RELATED [ChEBI:] synonym: "N-[2-(4-chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide" RELATED [ChEBI:] synonym: "N-[2-(4-chlorophenyl)ethyl]-7,8-dihydroxy-1,3,4,5-tetrahydro-2H-2-benzazepine-2-carbothioamide" EXACT IUPAC_NAME [IUPAC:] synonym: "N-[2-(4-chlorophenyl)ethyl]-7,8-dihydroxy-1,3,4,5-tetrahydro-2H-2-benzazepine-2-carbothioamide" RELATED [ChEBI:] synonym: "Oc1cc2CCCN(Cc2cc1O)C(=S)NCCc1ccc(Cl)cc1" RELATED SMILES [ChEBI:] synonym: "ST50826300" RELATED [ChEBI:] xref: ChemIDplus:138977-28-3 "CAS Registry Number" xref: CiteXplore:1422598 "PubMed citation" xref: CiteXplore:14757700 "PubMed citation" xref: CiteXplore:15032662 "PubMed citation" xref: CiteXplore:18230728 "PubMed citation" xref: CiteXplore:20719804 "PubMed citation" xref: CiteXplore:22922338 "PubMed citation" xref: CiteXplore:8027976 "PubMed citation" xref: CiteXplore:9126180 "PubMed citation" xref: CiteXplore:9197280 "PubMed citation" xref: CiteXplore:9257928 "PubMed citation" xref: Reaxys:7047754 "Reaxys Registry Number" xref: Wikipedia:Capsazepine "Wikipedia" is_a: CHEBI:33566 ! catechols is_a: CHEBI:35676 ! benzazepine is_a: CHEBI:51276 ! thioureas is_a: CHEBI:83403 ! monochlorobenzenes property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:71230 name: dihydrochalcones namespace: chebi_ontology def: "Any ketone that is 1,3-diphenylpropanone and its derivatives obtained by substitution." [] is_a: CHEBI:72544 ! flavonoids is_a: CHEBI:76224 ! aromatic ketone property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:71274 name: mannooligosaccharide derivative namespace: chebi_ontology def: "An oligosaccharide derivative that is derived from a mannooligosaccharide." [] synonym: "mannooligosaccharide derivatives" RELATED [ChEBI:] is_a: CHEBI:63563 ! oligosaccharide derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:71275 name: N-glycan derivative namespace: chebi_ontology def: "The term used to refer to the 'carbohydrate' portion of N-glycoproteins when attached to a nitrogen from asparagine or arginine side-chains, when this portion is a carbohydrate derivative." [] synonym: "N-glycan derivatives" RELATED [ChEBI:] is_a: CHEBI:65212 ! polysaccharide derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:71300 name: EC 2.* (transferase) inhibitor namespace: chebi_ontology def: "An enzyme inhibitor that inhibits the action of a transferase (EC 2.*)" [] synonym: "EC 2 inhibitor" RELATED [ChEBI:] synonym: "EC 2 inhibitors" RELATED [ChEBI:] synonym: "EC 2.* (transferase) inhibitors" RELATED [ChEBI:] synonym: "EC 2.* inhibitor" RELATED [ChEBI:] synonym: "EC 2.* inhibitors" RELATED [ChEBI:] synonym: "transferase inhibitor" RELATED [ChEBI:] synonym: "transferase inhibitors" RELATED [ChEBI:] xref: Wikipedia:Transferase "Wikipedia" is_a: CHEBI:23924 ! enzyme inhibitor property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:71543 name: rotenoid namespace: chebi_ontology def: "Members of the class of tetrahydrochromenochromene that consists of a cis-fused tetrahydrochromeno[3,4-b]chromene skeleton and its substituted derivatives. The term was originally restricted to natural products, but is now also used to describe semi-synthetic and fully synthetic compounds." [] synonym: "rotenoids" RELATED [ChEBI:] xref: Wikipedia:Rotenoids "Wikipedia" is_a: CHEBI:72544 ! flavonoids is_a: CHEBI:72579 ! tetrahydrochromenochromene property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:71989 name: ortho ester namespace: chebi_ontology def: "Any organooxygen compound that has the general formula RC(OR(1))(OR(2))(OR(3)), where R(1), R(2), R(3) =/= H." [] synonym: "[*]C(O[*])(O[*])O[*]" RELATED SMILES [ChEBI:] synonym: "CO3R4" RELATED FORMULA [ChEBI:] synonym: "ortho esters" RELATED [ChEBI:] synonym: "ortho-ester" RELATED [ChEBI:] synonym: "ortho-esters" RELATED [ChEBI:] synonym: "orthoester" RELATED [ChEBI:] synonym: "orthoesters" RELATED [ChEBI:] xref: Wikipedia:Orthoester "Wikipedia" is_a: CHEBI:36963 ! organooxygen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:72290 name: pyrithiamine namespace: chebi_ontology alt_id: CHEBI:39662 def: "A pyridinium ion that is 3-(2-hydroxyethyl)-2-methylpyridine substituted at position 1 by a (4-amino-2-methylpyrimidin-5-yl)methyl group." [] synonym: "1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium" RELATED [UniProt:] synonym: "1-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-3-(2-HYDROXYETHYL)-2-METHYLPYRIDINIUM" RELATED [PDBeChem:] synonym: "1-[(4-amino-2-methylpyrimidin-5-yl)methyl]-3-(2-hydroxyethyl)-2-methylpyridinium" EXACT IUPAC_NAME [IUPAC:] synonym: "C14H19N4O" RELATED FORMULA [ChEBI:] synonym: "Cc1ncc(C[n+]2cccc(CCO)c2C)c(N)n1" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C14H19N4O/c1-10-12(5-7-19)4-3-6-18(10)9-13-8-16-11(2)17-14(13)15/h3-4,6,8,19H,5,7,9H2,1-2H3,(H2,15,16,17)/q+1" RELATED InChI [ChEBI:] synonym: "InChIKey=PZWYDZMWPANLMB-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "pyrithiamine cation" RELATED [ChEBI:] xref: PDBeChem:218 "PDBeChem" xref: Reaxys:3913157 "Reaxys Registry Number" is_a: CHEBI:50334 ! pyridinium ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:72544 name: flavonoids namespace: chebi_ontology def: "Any organic molecular entity whose stucture is based on derivatives of a phenyl-substituted 1-phenylpropane possessing a C15 or C16 skeleton, or such a structure which is condensed with a C6-C3 lignan precursors. The term is a 'superclass' comprising all members of the classes of flavonoid, isoflavonoid, neoflavonoid, chalcones, dihydrochalcones, aurones, pterocarpan, coumestans, rotenoid, flavonolignan, homoflavonoid and flavonoid oligomers. Originally restricted to natural products, the term is also applied to synthetic compounds related to them." [] synonym: "flavonoid" RELATED [ChEBI:] xref: Wikipedia:Flavonoids "Wikipedia" is_a: CHEBI:25806 ! oxygen molecular entity is_a: CHEBI:50860 ! organic molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:72579 name: tetrahydrochromenochromene namespace: chebi_ontology def: "Any organic heteropolycyclic compound consisting of a cis-fused dihydro chromene rings and its substituted derivatives." [] synonym: "tetrahydrochromenochromenes" RELATED [ChEBI:] is_a: CHEBI:23232 ! chromenes property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:72581 name: rotenones namespace: chebi_ontology def: "Members of the class of rotenoid which consists of a 6a,12a-dihydrochromeno[3,4-b]chromen-12(6H)-one skeleton and its substituted products." [] synonym: "[*]c1c([*])c([*])c2C(=O)C3([*])c4c([*])c([*])c([*])c([*])c4OC([*])([*])C3([*])Oc2c1[*]" RELATED SMILES [ChEBI:] synonym: "C16O3R12" RELATED FORMULA [ChEBI:] is_a: CHEBI:3992 ! cyclic ketone is_a: CHEBI:71543 ! rotenoid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:72590 name: rhizoxin namespace: chebi_ontology def: "An macrolide antibiotic isolated from the pathogenic plant fungus Rhizopus microsporus. It also exhibits antitumour and antimitotic activity." [] synonym: "(1S,3S,5R,8S,10S,11R,13R,14E,16R,17R)-10-hydroxy-8-[(2S,3R,4E,6E,8E)-3-methoxy-4,8-dimethyl-9-(2-methyl-1,3-oxazol-4-yl)nona-4,6,8-trien-2-yl]-11,16-dimethyl-4,7,12,18-tetraoxatetracyclo[15.3.1.0(3,5).0(11,13)]henicos-14-ene-6,19-dione" EXACT IUPAC_NAME [IUPAC:] synonym: "[H][C@]12CC(=O)O[C@]([H])(C1)[C@H](C)\\C=C\\[C@@]1([H])O[C@]1(C)[C@@H](O)C[C@]([H])(OC(=O)[C@]1([H])O[C@@]1([H])C2)[C@H](C)[C@@H](OC)C(\\C)=C\\C=C\\C(C)=C\\c1coc(C)n1" RELATED SMILES [ChEBI:] synonym: "Antibiotic WF-1360" RELATED [ChemIDplus:] synonym: "C35H47NO9" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C35H47NO9/c1-19(13-25-18-41-23(5)36-25)9-8-10-21(3)32(40-7)22(4)27-17-29(37)35(6)30(45-35)12-11-20(2)26-14-24(16-31(38)42-26)15-28-33(43-28)34(39)44-27/h8-13,18,20,22,24,26-30,32-33,37H,14-17H2,1-7H3/b9-8+,12-11+,19-13+,21-10+/t20-,22+,24+,26-,27+,28+,29+,30-,32+,33-,35-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=OWPCHSCAPHNHAV-QIPOKPRISA-N" RELATED InChIKey [ChEBI:] synonym: "WF-1360" RELATED [ChemIDplus:] xref: ChemIDplus:90996-54-6 "CAS Registry Number" xref: CiteXplore:11169722 "PubMed citation" xref: CiteXplore:18344330 "PubMed citation" xref: CiteXplore:2364385 "PubMed citation" xref: CiteXplore:3120782 "PubMed citation" xref: CiteXplore:3753552 "PubMed citation" xref: CiteXplore:3755426 "PubMed citation" xref: CiteXplore:8392827 "PubMed citation" xref: Reaxys:5915392 "Reaxys Registry Number" is_a: CHEBI:25105 ! macrolide antibiotic is_a: CHEBI:32955 ! epoxide is_a: CHEBI:46812 ! 1,3-oxazoles property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:72596 name: papulacandin namespace: chebi_ontology def: "Any of the carbohydrate-containing antibiotic compounds obtained from the deuteromycetous fungus Papularia sphaerosperma and generally consisting of o-orsellinic acid linked via a spirocyclic structure to a lactose moiety with two different side-chains: a shorter fatty-acid chain at the O-(6') position and a longer side-chain at the O-(3) position of the glucose moiety. Papulacandin D, the simplest member of the papulacandin family, lacks the O-(6'-acyl-beta-galactoside) at the O-(4) position of the glucose residue. The papulacandins show potent antifungal activity against Candida albicans, Geotrichum lactis, Saccharomyces cerevisiae, and Pneumocytis carinii, but are inactive against filamentous fungi, bacteria, and protazoa." [] synonym: "papulacandins" RELATED [ChEBI:] xref: CiteXplore:12374387 "PubMed citation" xref: CiteXplore:20711516 "PubMed citation" xref: CiteXplore:324958 "PubMed citation" xref: CiteXplore:3839230 "PubMed citation" xref: CiteXplore:3839234 "PubMed citation" xref: CiteXplore:6360972 "PubMed citation" xref: CiteXplore:7440418 "PubMed citation" xref: CiteXplore:7649857 "PubMed citation" xref: CiteXplore:8468238 "PubMed citation" is_a: CHEBI:20857 ! C-glycosyl compound is_a: CHEBI:23007 ! carbohydrate-containing antibiotic is_a: CHEBI:35748 ! fatty acid ester is_a: CHEBI:38831 ! 2-benzofurans is_a: CHEBI:72600 ! spiroketal property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:72600 name: spiroketal namespace: chebi_ontology def: "A cyclic ketal in which the ketal carbon is the only common atom of two rings." [] synonym: "spiroacetal" RELATED [ChEBI:] synonym: "spiroacetals" RELATED [ChEBI:] synonym: "spiroketals" RELATED [ChEBI:] xref: CiteXplore:19262920 "PubMed citation" xref: CiteXplore:20024126 "PubMed citation" xref: CiteXplore:21076755 "PubMed citation" xref: CiteXplore:21604735 "PubMed citation" xref: CiteXplore:21860857 "PubMed citation" xref: CiteXplore:22421755 "PubMed citation" is_a: CHEBI:37948 ! oxaspiro compound is_a: CHEBI:59779 ! cyclic ketal property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:72630 name: papulacandin D namespace: chebi_ontology def: "A papulacandin that is papulacandin A in which the 6-O-acylgalactosyl group is replaced by a hydrogen. It is a carbohydrate-containing antibiotic from the deuteromycetous fungus Papularia sphaerosperma which shows potent antifungal activity against Candida albicans." [] synonym: "(+)-papulacandin D" RELATED [ChEBI:] synonym: "(+)-papulacandin-D" RELATED [ChEBI:] synonym: "(1S,3'R,4'S,5'R,6'R)-3',5,5',7-tetrahydroxy-6'-(hydroxymethyl)-3',4',5',6'-tetrahydro-3H-spiro[2-benzofuran-1,2'-pyran]-4'-yl (2E,4E,7S,8E,10E,14S)-7-hydroxy-8,14-dimethylhexadeca-2,4,8,10-tetraenoate" EXACT IUPAC_NAME [IUPAC:] synonym: "C31H42O10" RELATED FORMULA [ChEBI:] synonym: "CC[C@H](C)CC\\C=C\\C=C(/C)[C@@H](O)C\\C=C\\C=C\\C(=O)O[C@H]1[C@H](O)[C@@H](CO)O[C@]2(OCc3cc(O)cc(O)c23)[C@@H]1O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C31H42O10/c1-4-19(2)11-7-5-8-12-20(3)23(34)13-9-6-10-14-26(36)40-29-28(37)25(17-32)41-31(30(29)38)27-21(18-39-31)15-22(33)16-24(27)35/h5-6,8-10,12,14-16,19,23,25,28-30,32-35,37-38H,4,7,11,13,17-18H2,1-3H3/b8-5+,9-6+,14-10+,20-12+/t19-,23-,25+,28+,29-,30+,31-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=XKSZJTQIZHUMGA-HPZFVNCBSA-N" RELATED InChIKey [ChEBI:] synonym: "papulacandin-D" RELATED [ChEBI:] xref: ChemIDplus:61036-49-5 "CAS Registry Number" xref: CiteXplore:17305346 "PubMed citation" xref: CiteXplore:20711516 "PubMed citation" xref: CiteXplore:7440418 "PubMed citation" xref: Reaxys:7239678 "Reaxys Registry Number" is_a: CHEBI:26979 ! organic heterotricyclic compound is_a: CHEBI:63367 ! monosaccharide derivative is_a: CHEBI:72596 ! papulacandin property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:72695 name: organic molecule namespace: chebi_ontology def: "Any molecule that consists of at least one carbon atom as part of the electrically neutral entity." [] synonym: "organic molecules" RELATED [ChEBI:] is_a: CHEBI:25367 ! molecule is_a: CHEBI:50860 ! organic molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:72760 name: tryprostatin B namespace: chebi_ontology def: "A cyclic dipeptide that is brevianamide F (cyclo-L-Trp-L-Pro) substituted at position 2 on the indole ring by a prenyl group." [] synonym: "(3S,8aS)-3-{[2-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl}hexahydropyrrolo[1,2-a]pyrazine-1,4-dione" EXACT IUPAC_NAME [IUPAC:] synonym: "[H][C@@]12CCCN1C(=O)[C@H](Cc1c(CC=C(C)C)[nH]c3ccccc13)NC2=O" RELATED SMILES [ChEBI:] synonym: "C21H25N3O2" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C21H25N3O2/c1-13(2)9-10-17-15(14-6-3-4-7-16(14)22-17)12-18-21(26)24-11-5-8-19(24)20(25)23-18/h3-4,6-7,9,18-19,22H,5,8,10-12H2,1-2H3,(H,23,25)/t18-,19-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=GLWYBXPXOSKQAW-OALUTQOASA-N" RELATED InChIKey [ChEBI:] synonym: "triprostatin B" RELATED [ChEBI:] synonym: "tryprostatin B" EXACT [UniProt:] xref: CiteXplore:10780915 "PubMed citation" xref: CiteXplore:12946134 "PubMed citation" xref: CiteXplore:17047877 "PubMed citation" xref: CiteXplore:19373974 "PubMed citation" xref: CiteXplore:21031390 "PubMed citation" xref: CiteXplore:22617493 "PubMed citation" xref: CiteXplore:8557590 "PubMed citation" xref: CiteXplore:8698634 "PubMed citation" xref: CiteXplore:8698635 "PubMed citation" xref: Reaxys:7389902 "Reaxys Registry Number" xref: SUBMITTER:16000710 "PubMed citation" is_a: CHEBI:24828 ! indoles is_a: CHEBI:38958 ! indole alkaloid is_a: CHEBI:46761 ! dipeptide is_a: CHEBI:48337 ! pyrrolopyrazine property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:72813 name: exopolysaccharide namespace: chebi_ontology def: "A biomacromolecule composed of carbohydrate residues which is secreted by a microorganism into the surrounding environment." [] synonym: "exopolysaccharides" RELATED [ChEBI:] synonym: "extracellular polymeric substance" RELATED [ChEBI:] synonym: "extracellular polymeric substances" RELATED [ChEBI:] xref: CiteXplore:11160795 "PubMed citation" xref: CiteXplore:11785425 "PubMed citation" xref: CiteXplore:1444258 "PubMed citation" xref: CiteXplore:15738217 "PubMed citation" xref: CiteXplore:16075348 "PubMed citation" xref: CiteXplore:17440912 "PubMed citation" xref: CiteXplore:18097339 "PubMed citation" xref: CiteXplore:19453747 "PubMed citation" xref: CiteXplore:20172021 "PubMed citation" xref: CiteXplore:20631870 "PubMed citation" xref: CiteXplore:20718297 "PubMed citation" xref: CiteXplore:2688547 "PubMed citation" xref: CiteXplore:6354590 "PubMed citation" xref: MetaCyc:Exopolysaccharides "MetaCyc" xref: Wikipedia:Exopolysaccharide "Wikipedia" xref: Wikipedia:Extracellular_polymeric_substance "Wikipedia" is_a: CHEBI:33694 ! biomacromolecule property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:73474 name: acetylenic compound namespace: chebi_ontology def: "Any organic molecule containing a C#C bond." [] synonym: "[*]C#C[*]" RELATED SMILES [ChEBI:] synonym: "acetylenic compounds" RELATED [ChEBI:] synonym: "C#C containing compound" RELATED [ChEBI:] synonym: "C#C containing compounds" RELATED [ChEBI:] synonym: "C#C-containing compound" RELATED [ChEBI:] synonym: "C#C-containing compounds" RELATED [ChEBI:] synonym: "C2R2" RELATED FORMULA [ChEBI:] is_a: CHEBI:72695 ! organic molecule property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:73690 name: erythrose 4-phosphate/phosphoenolpyruvate family amino acid namespace: chebi_ontology def: "An L-alpha-amino acid which is biosynthesised from erythrose 4-phosphate and phosphoenolpyruvate (i.e. phenylalanine, tyrosine, and tryptophan). A closed class." [] synonym: "erythrose 4-phosphate and phosphoenolpyruvate family amino acid" RELATED [ChEBI:] synonym: "erythrose 4-phosphate and phosphoenolpyruvate family amino acids" RELATED [ChEBI:] synonym: "erythrose 4-phosphate family amino acid" RELATED [ChEBI:] synonym: "erythrose 4-phosphate family amino acids" RELATED [ChEBI:] synonym: "erythrose 4-phosphate/phosphoenolpyruvate family amino acids" RELATED [ChEBI:] synonym: "phosphoenolpyruvate family amino acid" RELATED [ChEBI:] synonym: "phosphoenolpyruvate family amino acids" RELATED [ChEBI:] is_a: CHEBI:15705 ! L-alpha-amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:74222 name: gamma-lactam namespace: chebi_ontology def: "A lactam in which the amide bond is contained within a five-membered ring, which includes the amide nitrogen and the carbonyl carbon." [] synonym: "gamma-lactams" RELATED [ChEBI:] is_a: CHEBI:24995 ! lactam property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:74498 name: 5-fluoroorotic acid namespace: chebi_ontology def: "A pyrimidinemonocarboxylic that is orotic acid which is substituted by fluorine at position 5. It is used in yeast molecular genetics to detect expression of the URA3 gene, which encodes orotine-5'-monophosphate dicarboxylase. A yeast with and active URA3 gene converts 5-fluoroorotic acid to fluorodeoxyuridine, which is toxic to cells." [] synonym: "1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-4-pyrimidinecarboxylic acid" RELATED [ChemIDplus:] synonym: "5-fluoro-1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid" RELATED [ChEBI:] synonym: "5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "5-fluoro-6-carboxyuracil" RELATED [ChEBI:] synonym: "5-fluorouracil-4-carboxylic acid" RELATED [ChemIDplus:] synonym: "ENT-26398" RELATED [ChemIDplus:] synonym: "FO" RELATED [ChemIDplus:] synonym: "FOA" RELATED [ChemIDplus:] synonym: "NSC 31712" RELATED [ChemIDplus:] synonym: "NSC-31712" RELATED [ChEBI:] synonym: "Ro 2-9945" RELATED [ChemIDplus:] xref: ChemIDplus:703-95-7 "CAS Registry Number" xref: CiteXplore:2675756 "PubMed citation" xref: CiteXplore:3323810 "PubMed citation" xref: CiteXplore:3586772 "PubMed citation" xref: Patent:GB806584 "Patent" xref: Patent:US2948725 "Patent" xref: Reaxys:181933 "Reaxys Registry Number" is_a: CHEBI:26447 ! pyrimidinemonocarboxylic acid is_a: CHEBI:37143 ! organofluorine compound is_a: CHEBI:67142 ! nucleobase analogue property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:74818 name: heteroaryl hydroxy compound namespace: chebi_ontology def: "Any organic aromatic compound having one or more hydroxy groups attached to a heteroarene ring." [] synonym: "hetaryl hydroxy compound" RELATED [ChEBI:] synonym: "hetaryl hydroxy compounds" RELATED [ChEBI:] synonym: "heteroaromatic hydroxy compound" RELATED [ChEBI:] synonym: "heteroaromatic hydroxy compounds" RELATED [ChEBI:] synonym: "heteroaryl hydroxy compounds" RELATED [ChEBI:] is_a: CHEBI:33659 ! organic aromatic compound is_a: CHEBI:33822 ! organic hydroxy compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:74961 name: raffinose family oligosaccharide namespace: chebi_ontology def: "Any oligosaccharide that has a biosynthetic pathway in common with that of raffinose." [] synonym: "raffinose family oligosaccharides" RELATED [ChEBI:] xref: CiteXplore:23621405 "PubMed citation" xref: CiteXplore:23727589 "PubMed citation" xref: CiteXplore:23879777 "PubMed citation" xref: CiteXplore:23882273 "PubMed citation" is_a: CHEBI:50699 ! oligosaccharide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:75044 name: phleomycin namespace: chebi_ontology def: "A mixture of glycopeptide antibiotics originally isolated from the bacterium Streptomyces verticillus whose components all contain a thiazolinylthiazole moiety and can form complexes with redox-active metals such as Co, Cu, and Fe. (Bleomycins are very similar to phleomycins, but have a bithiazole moiety in place of the thiazolinylthiazole moiety)." [] synonym: "phleomycins" RELATED [ChEBI:] xref: CiteXplore:13345730 "PubMed citation" xref: CiteXplore:13672899 "PubMed citation" xref: CiteXplore:19114524 "PubMed citation" xref: CiteXplore:19428369 "PubMed citation" xref: CiteXplore:2580623 "PubMed citation" xref: CiteXplore:6202668 "PubMed citation" xref: Wikipedia:Phleomycin "Wikipedia" is_a: CHEBI:60004 ! mixture property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:75253 name: phenylarsine oxide namespace: chebi_ontology def: "An arsine oxide derived from phenylarsine." [] synonym: "Arsenosobenzene" RELATED [ChemIDplus:] synonym: "C6H5AsO" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C6H5AsO/c8-7-6-4-2-1-3-5-6/h1-5H" RELATED InChI [ChEBI:] synonym: "InChIKey=BQVCCPGCDUSGOE-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "O=[As]c1ccccc1" RELATED SMILES [ChEBI:] synonym: "oxo(phenyl)arsine" EXACT IUPAC_NAME [IUPAC:] synonym: "Oxophenylarsine" RELATED [ChemIDplus:] synonym: "PhAsO" RELATED [ChEBI:] synonym: "Phenyl arsine oxide" RELATED [ChemIDplus:] synonym: "Phenylarsenoxide" RELATED [ChemIDplus:] xref: ChemIDplus:637-03-6 "CAS Registry Number" xref: CiteXplore:22048238 "PubMed citation" xref: CiteXplore:22617457 "PubMed citation" xref: CiteXplore:23044393 "PubMed citation" xref: CiteXplore:23201556 "PubMed citation" xref: PDBeChem:PA0 "PDBeChem" xref: Reaxys:2935227 "Reaxys Registry Number" is_a: CHEBI:35843 ! arsine oxides property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:75596 name: EC 5.* (isomerase) inhibitor namespace: chebi_ontology def: "An enzyme inhibitor that inhibits the action of an isomerase (EC 5.*.*.*)." [] synonym: "EC 5.* (isomerase) inhibitors" RELATED [ChEBI:] synonym: "EC 5.* inhibitor" RELATED [ChEBI:] synonym: "EC 5.* inhibitors" RELATED [ChEBI:] synonym: "EC 5.*.*.* inhibitor" RELATED [ChEBI:] synonym: "EC 5.*.*.* inhibitors" RELATED [ChEBI:] synonym: "isomerase (EC 5.*) inhibitor" RELATED [ChEBI:] synonym: "isomerase (EC 5.*) inhibitors" RELATED [ChEBI:] synonym: "isomerase inhibitor" RELATED [ChEBI:] synonym: "isomerase inhibitors" RELATED [ChEBI:] is_a: CHEBI:23924 ! enzyme inhibitor property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:7569 name: nigericin namespace: chebi_ontology alt_id: CHEBI:530451 def: "A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus." [] synonym: "(2R)-2-[(2R,3S,6R)-6-{[(2S,4R,5R,7R,9R,10R)-2-{(2S,2'R,3'S,5R,5'R)-5'-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl]-2,3'-dimethyloctahydro-2,2'-bifuran-5-yl}-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]dec-7-yl]methyl}-3-methyltetrahydro-2H-pyran-2-yl]propanoic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "[H][C@@]1(CC[C@H](C)[C@@]([H])(O1)[C@@H](C)C(O)=O)C[C@@H]1C[C@@H](OC)[C@@H](C)[C@]2(O1)O[C@@](C)(C[C@H]2C)[C@@]1([H])CC[C@](C)(O1)[C@]1([H])O[C@]([H])(C[C@@H]1C)[C@@]1([H])O[C@@](O)(CO)[C@H](C)C[C@@H]1C" RELATED SMILES [ChEBI:] synonym: "Azalomycin M" RELATED [ChemIDplus:] synonym: "C40H68O11" RELATED FORMULA [KEGG COMPOUND:] synonym: "Helixin C" RELATED [ChemIDplus:] synonym: "InChI=1S/C40H68O11/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34/h21-35,41,44H,11-20H2,1-10H3,(H,42,43)/t21-,22-,23-,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34-,35+,37-,38-,39-,40+/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=DANUORFCFTYTSZ-SJSJOXFOSA-N" RELATED InChIKey [ChEBI:] synonym: "Nigericin" EXACT [KEGG COMPOUND:] synonym: "Polyetherin A" RELATED [ChemIDplus:] xref: Beilstein:74670 "Beilstein Registry Number" xref: ChemIDplus:28380-24-7 "CAS Registry Number" xref: CiteXplore:10341035 "PubMed citation" xref: CiteXplore:10516103 "PubMed citation" xref: CiteXplore:10996433 "PubMed citation" xref: CiteXplore:15595852 "PubMed citation" xref: CiteXplore:17618633 "PubMed citation" xref: CiteXplore:20678563 "PubMed citation" xref: CiteXplore:20709811 "PubMed citation" xref: CiteXplore:20951746 "PubMed citation" xref: CiteXplore:21257734 "PubMed citation" xref: CiteXplore:22327078 "PubMed citation" xref: CiteXplore:22493436 "PubMed citation" xref: CiteXplore:7592045 "PubMed citation" xref: CiteXplore:7638257 "PubMed citation" xref: CiteXplore:7829226 "PubMed citation" xref: CiteXplore:8010949 "PubMed citation" xref: CiteXplore:8076364 "PubMed citation" xref: CiteXplore:8717427 "PubMed citation" xref: CiteXplore:8895841 "PubMed citation" xref: CiteXplore:8913333 "PubMed citation" xref: CiteXplore:9018148 "PubMed citation" xref: CiteXplore:9178132 "PubMed citation" xref: CiteXplore:9770325 "PubMed citation" xref: KEGG COMPOUND:28380-24-7 "CAS Registry Number" xref: KEGG COMPOUND:C11609 "KEGG COMPOUND" xref: KNApSAcK:C00018750 "KNApSAcK" xref: Patent:US3555150 "Patent" xref: Reaxys:74670 "Reaxys Registry Number" xref: Wikipedia:Nigericin "Wikipedia" is_a: CHEBI:36468 ! polycyclic ether property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:76224 name: aromatic ketone namespace: chebi_ontology def: "A ketone in which the carbonyl group is attached to an aromatic ring." [] synonym: "aromatic ketones" RELATED [ChEBI:] synonym: "aryl ketone" RELATED [ChEBI:] synonym: "aryl ketones" RELATED [ChEBI:] is_a: CHEBI:17087 ! ketone property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:76578 name: disubstituted glycerol namespace: chebi_ontology def: "Any lipid that is glycerol bearing two substituent groups - either acyl, alkyl, or alk-1-enyl - at any two of the three possible positions." [] synonym: "diorganylglycerol" RELATED [ChEBI:] synonym: "diradylglycerol" RELATED [ChEBI:] xref: SUBMITTER:LMGL0201 "LIPID MAPS class" is_a: CHEBI:18059 ! lipid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:7660 name: nystatin namespace: chebi_ontology def: "A polyene macrolide antibiotic; part of the nystatin complex produced by several Streptococcus species. The keto-form of nystatin A1." [] synonym: "(21E,23E,25E,27E,31E,33E)-20-[(3-amino-3,6-dideoxy-D-mannopyranosyl)oxy]-4,6,8,11,12,16,18,36-octahydroxy-35,37,38-trimethyl-2,14-dioxooxacyclooctatriaconta-21,23,25,27,31,33-hexaene-17-carboxylic acid" EXACT IUPAC_NAME [IUPAC:] synonym: "C47H75NO17" RELATED FORMULA [KEGG COMPOUND:] synonym: "CC1OC(=O)CC(O)CC(O)CC(O)CCC(O)C(O)CC(=O)CC(O)C(C(O)CC(OC2O[C@H](C)[C@@H](O)[C@H](N)[C@@H]2O)\\C=C\\C=C\\C=C\\C=C\\CC\\C=C\\C=C\\C(C)C(O)C1C)C(O)=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-35(65-47-45(60)42(48)44(59)30(4)64-47)26-39(56)41(46(61)62)38(55)24-34(52)23-37(54)36(53)20-19-31(49)21-32(50)22-33(51)25-40(57)63-29(3)28(2)43(27)58/h5-6,8,10-18,27-33,35-39,41-45,47,49-51,53-56,58-60H,7,9,19-26,48H2,1-4H3,(H,61,62)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27?,28?,29?,30-,31?,32?,33?,35?,36?,37?,38?,39?,41?,42+,43?,44-,45+,47?/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=ZDFDJJJGIRGMBE-AFARJNEBSA-N" RELATED InChIKey [ChEBI:] synonym: "Nystatin" EXACT [KEGG COMPOUND:] synonym: "nystatin" RELATED INN [KEGG DRUG:] xref: DrugBank:DB00646 "DrugBank" xref: KEGG COMPOUND:1400-61-9 "CAS Registry Number" xref: KEGG COMPOUND:C06572 "KEGG COMPOUND" xref: KEGG DRUG:D00202 "KEGG DRUG" xref: LIPID MAPS:LMPK06000001 "LIPID MAPS instance" is_a: CHEBI:59676 ! nystatins property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:76620 name: S-methyl-L-ergothioneine namespace: chebi_ontology def: "An amino acid betaine that is ergothioneine in which the hydrogen attached to the sulfur is replaced by a methyl group. It has been isolated from the deepwater (500-1,600 m) marine sponge Macandrewia azorica." [] synonym: "(+)-L-methylergothioneine" RELATED [ChEBI:] synonym: "(+)-L-S-methylergothioneine" RELATED [ChEBI:] synonym: "(+)-S-methyl-L-ergothioneine" RELATED [ChEBI:] synonym: "(+)-S-methylergothioneine" RELATED [ChEBI:] synonym: "(2S)-3-(2-methylsulfanyl-1H-imidazol-5-yl)-2-(trimethylazaniumyl)propanoate" EXACT IUPAC_NAME [IUPAC:] synonym: "(2S)-3-[2-(methylsulfanyl)-1H-imidazol-4-yl]-2-(trimethylammonio)propanoate" EXACT IUPAC_NAME [IUPAC:] synonym: "(2S)-3-[2-(methylsulfanyl)-1H-imidazol-4-yl]-2-(trimethylammonio)propionate" RELATED [ChEBI:] synonym: "7S-(+)-methylergothioneine" RELATED [ChEBI:] synonym: "C10H17N3O2S" RELATED FORMULA [ChEBI:] synonym: "CSc1ncc(C[C@@H](C([O-])=O)[N+](C)(C)C)[nH]1" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C10H17N3O2S/c1-13(2,3)8(9(14)15)5-7-6-11-10(12-7)16-4/h6,8H,5H2,1-4H3,(H-,11,12,14,15)/t8-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=GVQNHIYBRMFCMS-QMMMGPOBSA-N" RELATED InChIKey [ChEBI:] synonym: "L-(+)-S-methylergothioneine" RELATED [ChEBI:] synonym: "L-S-methylergothioneine" RELATED [ChEBI:] synonym: "S-methylergothioneine" RELATED [ChEBI:] xref: CiteXplore:15340692 "PubMed citation" xref: CiteXplore:24167631 "PubMed citation" xref: CiteXplore:8615839 "PubMed citation" is_a: CHEBI:16385 ! organic sulfide is_a: CHEBI:22860 ! amino-acid betaine is_a: CHEBI:24780 ! imidazoles property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:76668 name: EC 2.7.* (P-containing group transferase) inhibitor namespace: chebi_ontology def: "A transferase inhibitor that inhibits the action of a phosphorus-containing group transferase (EC 2.7.*.*)." [] synonym: "EC 2.7.* (P-containing group transferase) inhibitors" RELATED [ChEBI:] synonym: "EC 2.7.* (phosphorus-containing group transferase) inhibitor" RELATED [ChEBI:] synonym: "EC 2.7.* (phosphorus-containing group transferase) inhibitors" RELATED [ChEBI:] synonym: "EC 2.7.* inhibitor" RELATED [ChEBI:] synonym: "EC 2.7.* inhibitors" RELATED [ChEBI:] synonym: "phosphorus-containing group transferase (EC 2.7.*) inhibitor" RELATED [ChEBI:] synonym: "phosphorus-containing group transferase (EC 2.7.*) inhibitors" RELATED [ChEBI:] synonym: "phosphorus-containing group transferase inhibitor" RELATED [ChEBI:] synonym: "phosphorus-containing group transferase inhibitors" RELATED [ChEBI:] is_a: CHEBI:71300 ! EC 2.* (transferase) inhibitor property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:76697 name: EC 5.99.* (other isomerases) inhibitor namespace: chebi_ontology def: "An isomerase inhibitor that interferes with the action of any member of the group of 'other isomerases' (EC 5.99.*.*)." [] synonym: "EC 5.99.* (miscellaneous isomerases) inhibitor" RELATED [ChEBI:] synonym: "EC 5.99.* (miscellaneous isomerases) inhibitors" RELATED [ChEBI:] synonym: "EC 5.99.* (other isomerase) inhibitor" RELATED [ChEBI:] synonym: "EC 5.99.* (other isomerase) inhibitors" RELATED [ChEBI:] synonym: "EC 5.99.* (other isomerases) inhibitors" RELATED [ChEBI:] synonym: "EC 5.99.* inhibitor" RELATED [ChEBI:] synonym: "EC 5.99.* inhibitors" RELATED [ChEBI:] is_a: CHEBI:75596 ! EC 5.* (isomerase) inhibitor property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:76759 name: EC 3.* (hydrolase) inhibitor namespace: chebi_ontology def: "Any enzyme inhibitor that interferes with the action of a hydrolase (EC 3.*.*.*)." [] synonym: "EC 3.* (hydrolase) inhibitors" RELATED [ChEBI:] synonym: "EC 3.* inhibitor" RELATED [ChEBI:] synonym: "EC 3.* inhibitors" RELATED [ChEBI:] synonym: "EC 3.*.*.* inhibitor" RELATED [ChEBI:] synonym: "EC 3.*.*.* inhibitors" RELATED [ChEBI:] synonym: "hydrolase (EC 3.*) inhibitor" RELATED [ChEBI:] synonym: "hydrolase (EC 3.*) inhibitors" RELATED [ChEBI:] synonym: "hydrolase inhibitor" RELATED [ChEBI:] synonym: "hydrolase inhibitors" RELATED [ChEBI:] xref: Wikipedia:Hydrolase "Wikipedia" is_a: CHEBI:23924 ! enzyme inhibitor property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:76812 name: EC 2.7.11.* (protein-serine/threonine kinase) inhibitor namespace: chebi_ontology def: "An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of any protein-serine/threonine kinase (EC 2.7.11.*)." [] synonym: "EC 2.7.11.* (protein-serine/threonine kinase) inhibitors" RELATED [ChEBI:] synonym: "EC 2.7.11.* inhibitor" RELATED [ChEBI:] synonym: "EC 2.7.11.* inhibitors" RELATED [ChEBI:] synonym: "protein-serine/threonine kinase (EC 2.7.11.*) inhibitor" RELATED [ChEBI:] synonym: "protein-serine/threonine kinase (EC 2.7.11.*) inhibitors" RELATED [ChEBI:] synonym: "protein-serine/threonine kinase inhibitor" RELATED [ChEBI:] synonym: "protein-serine/threonine kinase inhibitors" RELATED [ChEBI:] is_a: CHEBI:76668 ! EC 2.7.* (P-containing group transferase) inhibitor property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:76830 name: EC 5.99.1.* (miscellaneous isomerase) inhibitor namespace: chebi_ontology def: "An EC 5.99.* (other isomerases) inhibitor that interferes with the activity of any enzyme in the EC 5.99.1.* class." [] synonym: "EC 5.99.1.* (miscellaneous isomerase) inhibitors" RELATED [ChEBI:] synonym: "EC 5.99.1.* inhibitor" RELATED [ChEBI:] synonym: "EC 5.99.1.* inhibitors" RELATED [ChEBI:] is_a: CHEBI:76697 ! EC 5.99.* (other isomerases) inhibitor property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:78574 name: pyrimidinecarboxylic acid namespace: chebi_ontology def: "Any pyrimidine that bears one or more carboxylic acid substituents." [] synonym: "pyrimidinecarboxylic acids" RELATED [ChEBI:] is_a: CHEBI:33575 ! carboxylic acid is_a: CHEBI:39447 ! pyrimidines property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:78616 name: carbohydrates and carbohydrate derivatives namespace: chebi_ontology def: "Any organooxygen compound that is a polyhydroxy-aldehyde or -ketone, or a compound derived from one. Carbohydrates contain only carbon, hydrogen and oxygen and usually have an empirical formula Cm(H2O)n; carbohydrate derivatives may contain other elements by substitution or condensation." [] synonym: "carbohydrates and derivatives" RELATED [ChEBI:] synonym: "carbohydrates and their derivatives" RELATED [ChEBI:] is_a: CHEBI:36963 ! organooxygen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:78673 name: cumene hydroperoxide namespace: chebi_ontology def: "A peroxol that is cumene in which the alpha-hydrogen is replaced by a hydroperoxy group." [] synonym: "1-Methyl-1-phenylethyl hydroperoxide" RELATED [NIST Chemistry WebBook:] synonym: "7-Cumyl hydroperoxide" RELATED [ChemIDplus:] synonym: "alpha,alpha-Dimethylbenzyl hydroperoxide" RELATED [ChemIDplus:] synonym: "alpha-Cumene hydroperoxide" RELATED [NIST Chemistry WebBook:] synonym: "alpha-Cumyl hydroperoxide" RELATED [NIST Chemistry WebBook:] synonym: "C9H12O2" RELATED FORMULA [ChEBI:] synonym: "CC(C)(OO)c1ccccc1" RELATED SMILES [ChEBI:] synonym: "Cumenyl hydroperoxide" RELATED [ChemIDplus:] synonym: "Cumolhydroperoxid" RELATED [ChemIDplus:] synonym: "Cumyl hydroperoxide" RELATED [ChemIDplus:] synonym: "Hydroperoxyde de cumene" RELATED [ChemIDplus:] synonym: "Hydroperoxyde de cumyle" RELATED [ChemIDplus:] synonym: "InChI=1S/C9H12O2/c1-9(2,11-10)8-6-4-3-5-7-8/h3-7,10H,1-2H3" RELATED InChI [ChEBI:] synonym: "InChIKey=YQHLDYVWEZKEOX-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "Isopropylbenzene hydroperoxide" RELATED [NIST Chemistry WebBook:] xref: ChemIDplus:80-15-9 "CAS Registry Number" xref: CiteXplore:23357941 "PubMed citation" xref: CiteXplore:23707950 "PubMed citation" xref: CiteXplore:23767299 "PubMed citation" xref: CiteXplore:24073228 "PubMed citation" xref: CiteXplore:24492382 "PubMed citation" xref: MetaCyc:CPD0-1449 "MetaCyc" xref: NIST Chemistry WebBook:80-15-9 "CAS Registry Number" xref: Reaxys:1908117 "Reaxys Registry Number" xref: Wikipedia:Cumene_hydroperoxide "Wikipedia" is_a: CHEBI:35924 ! peroxol property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:78763 name: EC 2.7.11.18 (myosin-light-chain kinase) inhibitor namespace: chebi_ontology def: "An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of myosin-light-chain kinase (EC 2.7.11.18)." [] synonym: "[myosin-light-chain] kinase inhibitor" RELATED [ChEBI:] synonym: "[myosin-light-chain] kinase inhibitors" RELATED [ChEBI:] synonym: "ATP:[myosin-light-chain] O-phosphotransferase inhibitor" RELATED [ChEBI:] synonym: "ATP:[myosin-light-chain] O-phosphotransferase inhibitors" RELATED [ChEBI:] synonym: "ATP:myosin-light-chain O-phosphotransferase inhibitor" RELATED [ChEBI:] synonym: "ATP:myosin-light-chain O-phosphotransferase inhibitors" RELATED [ChEBI:] synonym: "calcium/calmodulin-dependent myosin light chain kinase inhibitor" RELATED [ChEBI:] synonym: "calcium/calmodulin-dependent myosin light chain kinase inhibitors" RELATED [ChEBI:] synonym: "EC 2.7.11.18 (myosin-light-chain kinase) inhibitors" RELATED [ChEBI:] synonym: "EC 2.7.11.18 inhibitor" RELATED [ChEBI:] synonym: "EC 2.7.11.18 inhibitors" RELATED [ChEBI:] synonym: "MLCK inhibitor" RELATED [ChEBI:] synonym: "MLCK inhibitors" RELATED [ChEBI:] synonym: "MLCkase inhibitor" RELATED [ChEBI:] synonym: "MLCkase inhibitors" RELATED [ChEBI:] synonym: "myosin kinase inhibitor" RELATED [ChEBI:] synonym: "myosin kinase inhibitors" RELATED [ChEBI:] synonym: "myosin light chain kinase inhibitor" RELATED [ChEBI:] synonym: "myosin light chain kinase inhibitors" RELATED [ChEBI:] synonym: "myosin light chain protein kinase inhibitor" RELATED [ChEBI:] synonym: "myosin light chain protein kinase inhibitors" RELATED [ChEBI:] synonym: "myosin light-chain kinase (phosphorylating) inhibitor" RELATED [ChEBI:] synonym: "myosin light-chain kinase (phosphorylating) inhibitors" RELATED [ChEBI:] synonym: "myosin light-chain kinase inhibitor" RELATED [ChEBI:] synonym: "myosin light-chain kinase inhibitors" RELATED [ChEBI:] synonym: "myosin-light-chain kinase (EC 2.7.11.18) inhibitor" RELATED [ChEBI:] synonym: "myosin-light-chain kinase (EC 2.7.11.18) inhibitors" RELATED [ChEBI:] synonym: "myosin-light-chain kinase inhibitor" RELATED [ChEBI:] synonym: "myosin-light-chain kinase inhibitors" RELATED [ChEBI:] synonym: "smooth-muscle-myosin-light-chain kinase inhibitor" RELATED [ChEBI:] synonym: "smooth-muscle-myosin-light-chain kinase inhibitors" RELATED [ChEBI:] xref: Wikipedia:Myosin_light-chain_kinase "Wikipedia" is_a: CHEBI:76812 ! EC 2.7.11.* (protein-serine/threonine kinase) inhibitor property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:78840 name: olefinic compound namespace: chebi_ontology def: "Any organic molecular entity that contains at least one C=C bond." [] synonym: "olefinic compounds" RELATED [ChEBI:] is_a: CHEBI:50860 ! organic molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:79020 name: alpha,beta-unsaturated monocarboxylic acid namespace: chebi_ontology def: "A monocarboxylic acid in which the carbon of the carboxy group is directly attached to a C=C or C#C bond." [] synonym: "2,3-unsaturated monocarboxylic acid" RELATED [ChEBI:] synonym: "2,3-unsaturated monocarboxylic acids" RELATED [ChEBI:] synonym: "alpha,beta-unsaturated monocarboxylic acids" RELATED [ChEBI:] is_a: CHEBI:25384 ! monocarboxylic acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:79030 name: S-adenosyl-3-thiopropylamine namespace: chebi_ontology def: "A thioadenosine that is adenosine in which the hydroxy group at C-5' is replaced by a 3-aminopropyl group." [] synonym: "5'-S-(3-aminopropyl)-5'-thioadenosine" EXACT IUPAC_NAME [IUPAC:] synonym: "C13H20N6O3S" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C13H20N6O3S/c14-2-1-3-23-4-7-9(20)10(21)13(22-7)19-6-18-8-11(15)16-5-17-12(8)19/h5-7,9-10,13,20-21H,1-4,14H2,(H2,15,16,17)/t7-,9-,10-,13-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=FUSRAALGPJJIRO-QYVSTXNMSA-N" RELATED InChIKey [ChEBI:] synonym: "NCCCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12" RELATED SMILES [ChEBI:] xref: ChemIDplus:53186-57-5 "CAS Registry Number" xref: CiteXplore:6621400 "PubMed citation" xref: CiteXplore:7396856 "PubMed citation" xref: CiteXplore:942371 "PubMed citation" xref: PDBeChem:DSH "PDBeChem" xref: Reaxys:577457 "Reaxys Registry Number" is_a: CHEBI:16385 ! organic sulfide is_a: CHEBI:26953 ! thioadenosine is_a: CHEBI:50994 ! primary amino compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:79057 name: hercynylcysteine sulfoxide namespace: chebi_ontology def: "A L-histidine derivative which is an intermediate in the synthesis of ergothioneine, a compound found in certain fungi and mycobacteria." [] synonym: "(2S)-3-(2-{[(2R)-2-amino-2-carboxyethyl]sulfinyl}-1H-imidazol-4-yl)-2-(trimethylazaniumyl)propanoate" EXACT IUPAC_NAME [IUPAC:] synonym: "C12H20N4O5S" RELATED FORMULA [ChEBI:] synonym: "C[N+](C)(C)[C@@H](Cc1c[nH]c(n1)S(=O)C[C@H](N)C(O)=O)C([O-])=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C12H20N4O5S/c1-16(2,3)9(11(19)20)4-7-5-14-12(15-7)22(21)6-8(13)10(17)18/h5,8-9H,4,6,13H2,1-3H3,(H2-,14,15,17,18,19,20)/t8-,9-,22?/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=CSTNDZVKJNPMIG-PTZMPWRZSA-N" RELATED InChIKey [ChEBI:] xref: CiteXplore:22209968 "PubMed citation" xref: CiteXplore:24828577 "PubMed citation" xref: CiteXplore:24958269 "PubMed citation" xref: Reaxys:24604971 "Reaxys Registry Number" xref: SUBMITTER:CPD-15277 "MetaCyc" is_a: CHEBI:35284 ! ammonium betaine is_a: CHEBI:35813 ! sulfoxide is_a: CHEBI:83824 ! L-cysteine derivative is_a: CHEBI:84076 ! L-histidine derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:79070 name: hercynylselenocysteine namespace: chebi_ontology def: "A L-histidine derivative which is an intermediate in the synthesis of selenoneine, a compound found in certain fungi and mycobacteria." [] synonym: "(2S)-3-(2-{[(2R)-2-amino-2-carboxyethyl]selanyl}-1H-imidazol-4-yl)-2-(trimethylazaniumyl)propanoate" EXACT IUPAC_NAME [IUPAC:] synonym: "C12H20N4O4Se" RELATED FORMULA [ChEBI:] synonym: "C[N+](C)(C)[C@@H](Cc1c[nH]c([Se]C[C@H](N)C(O)=O)n1)C([O-])=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C12H20N4O4Se/c1-16(2,3)9(11(19)20)4-7-5-14-12(15-7)21-6-8(13)10(17)18/h5,8-9H,4,6,13H2,1-3H3,(H2-,14,15,17,18,19,20)/t8-,9-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=WUKYFFAYSLDGLI-IUCAKERBSA-N" RELATED InChIKey [ChEBI:] xref: SUBMITTER:24828577 "PubMed citation" is_a: CHEBI:26629 ! selenoamino acid is_a: CHEBI:35284 ! ammonium betaine is_a: CHEBI:84076 ! L-histidine derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:79071 name: selenoneine namespace: chebi_ontology alt_id: CHEBI:82733 def: "A histidine derivative that is N(alpha),N(alpha),N(alpha)-trimethyl-L-histidine substituted by a selenoxo group at position 2 on the imidazole ring. A selenium-containing antioxidant found in tuna blood." [] synonym: "(2S)-3-(2-selenoxo-2,3-dihydro-1H-imidazol-4-yl)-2-(trimethylazaniumyl)propanoate" EXACT IUPAC_NAME [IUPAC:] synonym: "2-selenyl-N(alpha),N(alpha),N(alpha)-trimethyl-L-histidine" RELATED [SUBMITTER:] synonym: "C9H15N3O2Se" RELATED FORMULA [ChEBI:] synonym: "C[N+](C)(C)[C@@H](Cc1c[nH][c](=[Se])[nH]1)C([O-])=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C9H15N3O2Se/c1-12(2,3)7(8(13)14)4-6-5-10-9(15)11-6/h5,7H,4H2,1-3H3,(H2-,10,11,13,14,15)/t7-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=MTIQLELFQVCRSW-ZETCQYMHSA-N" RELATED InChIKey [ChEBI:] synonym: "selenoergothioneine" RELATED [ChEBI:] synonym: "selnoneine thione" RELATED [UniProt:] xref: CiteXplore:20388714 "PubMed citation" xref: CiteXplore:21331438 "PubMed citation" xref: CiteXplore:21540999 "PubMed citation" xref: CiteXplore:22129736 "PubMed citation" xref: CiteXplore:23434904 "PubMed citation" xref: CiteXplore:24197605 "PubMed citation" xref: CiteXplore:PMC4117592 "PubMed Central citation" xref: Reaxys:15579936 "Reaxys Registry Number" xref: SUBMITTER:23709046 "PubMed citation" xref: SUBMITTER:24828577 "PubMed citation" is_a: CHEBI:22860 ! amino-acid betaine is_a: CHEBI:84076 ! L-histidine derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:79385 name: YW3548 namespace: chebi_ontology def: "A terpene lactone that is obtained from Codinea simplex and acts as an inhibitor of glycerophosphoinositol biosynthesis." [] synonym: "(1R,4R,4aR,6Z,7aR,8aR,10S,11S,11aR,12aR,13aR)-1,13a-dihydroxy-11-isopropyl-4,7,8a-trimethyl-13-methylene-2-oxo-1,2,4,4a,5,7a,8,8a,9,10,11,11a,12,12a,13,13a-hexadecahydroindeno[5',6':4,5]cycloocta[1,2-c]pyran-10-yl 3-hydroxy-3,5-dimethylheptanoate" EXACT IUPAC_NAME [IUPAC:] synonym: "C34H54O7" RELATED FORMULA [ChEBI:] synonym: "CCC(C)CC(C)(O)CC(=O)O[C@H]1C[C@@]2(C)C[C@@H]3[C@@H](C[C@@H]2[C@@H]1C(C)C)C(=C)[C@@]1(O)[C@@H](O)C(=O)O[C@H](C)[C@H]1C\\C=C3\\C" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C34H54O7/c1-10-19(4)14-33(9,38)17-28(35)41-27-16-32(8)15-24-20(5)11-12-25-22(7)40-31(37)30(36)34(25,39)21(6)23(24)13-26(32)29(27)18(2)3/h11,18-19,22-27,29-30,36,38-39H,6,10,12-17H2,1-5,7-9H3/b20-11-/t19?,22-,23+,24+,25-,26-,27+,29+,30+,32-,33?,34+/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=WYHGVXYOQWYOQA-WHRQVDIESA-N" RELATED InChIKey [ChEBI:] synonym: "YW 3548" RELATED [ChEBI:] synonym: "YW-3548" RELATED [ChEBI:] xref: CiteXplore:10574991 "PubMed citation" xref: CiteXplore:17947228 "PubMed citation" xref: CiteXplore:9351820 "PubMed citation" xref: CiteXplore:9576863 "PubMed citation" is_a: CHEBI:26878 ! tertiary alcohol is_a: CHEBI:37668 ! terpene lactone is_a: CHEBI:78840 ! olefinic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:79388 name: divalent inorganic anion namespace: chebi_ontology def: "Any inorganic anion with a valency of two." [] synonym: "divalent inorganic anions" RELATED [ChEBI:] is_a: CHEBI:24834 ! inorganic anion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:79389 name: monovalent inorganic anion namespace: chebi_ontology def: "Any inorganic anion with a valency of one." [] synonym: "monovalent inorganic anions" RELATED [ChEBI:] is_a: CHEBI:24834 ! inorganic anion property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:8113 name: phlorizin namespace: chebi_ontology def: "An aryl beta-D-glucoside that is phloretin attached to a beta-D-glucopyranosyl residue at position 2' via a glycosidic linkage." [] synonym: "3,5-dihydroxy-2-[3-(4-hydroxyphenyl)propanoyl]phenyl beta-D-glucopyranoside" EXACT IUPAC_NAME [IUPAC:] synonym: "C21H24O10" RELATED FORMULA [KEGG COMPOUND:] synonym: "Floridzin" RELATED [ChemIDplus:] synonym: "InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=IOUVKUPGCMBWBT-QNDFHXLGSA-N" RELATED InChIKey [ChEBI:] synonym: "OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O" RELATED SMILES [ChEBI:] synonym: "Phloretin 2'-glucoside" RELATED [ChemIDplus:] synonym: "Phlorhizin" RELATED [KEGG COMPOUND:] synonym: "Phloridzin" RELATED [KEGG COMPOUND:] synonym: "Phlorizin" EXACT [KEGG COMPOUND:] synonym: "Phlorizoside" RELATED [ChemIDplus:] xref: Beilstein:66621 "Beilstein Registry Number" xref: ChemIDplus:60-81-1 "CAS Registry Number" xref: CiteXplore:18573104 "PubMed citation" xref: CiteXplore:24392851 "PubMed citation" xref: HMDB:HMDB36634 "HMDB" xref: KEGG COMPOUND:60-81-1 "CAS Registry Number" xref: KEGG COMPOUND:C01604 "KEGG COMPOUND" xref: KNApSAcK:C00000990 "KNApSAcK" xref: MetaCyc:CPD-12447 "MetaCyc" xref: Patent:CN102697895 "Patent" xref: Patent:CN103214530 "Patent" xref: Reaxys:66621 "Reaxys Registry Number" xref: Wikipedia:Phlorizin "Wikipedia" is_a: CHEBI:28749 ! aryl beta-D-glucoside is_a: CHEBI:63367 ! monosaccharide derivative is_a: CHEBI:71230 ! dihydrochalcones property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:82663 name: elemental iron namespace: chebi_ontology def: "An elemental molecular entity in which all of the atoms have atomic number 26." [] is_a: CHEBI:24873 ! iron molecular entity is_a: CHEBI:33259 ! elemental molecular entity property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:8273 name: plumbagin namespace: chebi_ontology def: "A naphthoquinone that is 1,4-naphthoquinone in which the hydrogens at positions 2 and 5 are substituted by methyl and hydroxy groups, respectively." [] synonym: "2-methyl-5-hydroxy-1,4-naphthoquinone" RELATED [ChemIDplus:] synonym: "2-methyljuglone" RELATED [ChEBI:] synonym: "5-hydroxy-2-methyl-1,4-naphthalenedione" RELATED [ChemIDplus:] synonym: "5-hydroxy-2-methyl-1,4-naphthoquinone" RELATED [ChEBI:] synonym: "5-hydroxy-2-methylnaphthalene-1,4-dione" EXACT IUPAC_NAME [IUPAC:] synonym: "C11H8O3" RELATED FORMULA [KEGG COMPOUND:] synonym: "CC1=CC(=O)c2c(O)cccc2C1=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C11H8O3/c1-6-5-9(13)10-7(11(6)14)3-2-4-8(10)12/h2-5,12H,1H3" RELATED InChI [ChEBI:] synonym: "InChIKey=VCMMXZQDRFWYSE-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "plumbaein" RELATED [ChEBI:] synonym: "Plumbagin" EXACT [KEGG COMPOUND:] synonym: "plumbagine" RELATED [MetaCyc:] synonym: "plumbagone" RELATED [ChEBI:] xref: ChemIDplus:1870475 "Beilstein Registry Number" xref: ChemIDplus:481-42-5 "CAS Registry Number" xref: CiteXplore:14727919 "PubMed citation" xref: CiteXplore:14762525 "PubMed citation" xref: CiteXplore:16078700 "PubMed citation" xref: CiteXplore:16624823 "PubMed citation" xref: CiteXplore:18974148 "PubMed citation" xref: CiteXplore:19748668 "PubMed citation" xref: CiteXplore:20858709 "PubMed citation" xref: CiteXplore:21064184 "PubMed citation" xref: CiteXplore:21559086 "PubMed citation" xref: CiteXplore:21658027 "PubMed citation" xref: CiteXplore:21741707 "PubMed citation" xref: CiteXplore:9581522 "PubMed citation" xref: Gmelin:959690 "Gmelin Registry Number" xref: KEGG COMPOUND:481-42-5 "CAS Registry Number" xref: KEGG COMPOUND:C10387 "KEGG COMPOUND" xref: KNApSAcK:C00002852 "KNApSAcK" xref: MetaCyc:CPD-4461 "MetaCyc" xref: Patent:CN1473468 "Patent" xref: Patent:IN183682 "Patent" xref: Patent:IN191797 "Patent" xref: Reaxys:1870475 "Reaxys Registry Number" xref: Wikipedia:Plumbagin "Wikipedia" is_a: CHEBI:25481 ! naphthoquinone is_a: CHEBI:33853 ! phenols property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:83265 name: papuamide B namespace: chebi_ontology def: "A cyclodepsipeptide that is isolated from Papua New Guinea collections of the marine sponges Theonella mirabilis and Theonella swinhoei. It exhbits anti-HIV-1 activity and cytotoxicity against some human cancer cell lines." [] synonym: "C65H103N13O21" RELATED FORMULA [ChEBI:] synonym: "CC[C@@H](C)\\C=C(/C)\\C=C/[C@@H](O)[C@](C)(O)C(=O)NCC(=O)N[C@H]([C@@H](C)O)C(=O)N[C@@H]([C@H](C)N)C(=O)N[C@@H]([C@@H](C)[C@@H](C)C(N)=O)C(=O)N[C@@H]1[C@H](OC(=O)[C@@H]2CCCCN2C(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](COC)NC1=O)[C@@H](C)O)[C@H](OC)c1ccc(O)cc1)C(C)C" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C65H103N13O21/c1-15-31(4)26-32(5)19-24-43(82)65(12,96)64(95)69-28-45(84)72-48(37(10)79)59(90)74-47(35(8)66)58(89)73-46(33(6)34(7)54(67)85)57(88)76-50-52(30(2)3)99-63(94)42-18-16-17-25-78(42)62(93)51(53(98-14)39-20-22-40(81)23-21-39)77-60(91)49(38(11)80)75-55(86)36(9)70-44(83)27-68-56(87)41(29-97-13)71-61(50)92/h19-24,26,30-31,33-38,41-43,46-53,79-82,96H,15-18,25,27-29,66H2,1-14H3,(H2,67,85)(H,68,87)(H,69,95)(H,70,83)(H,71,92)(H,72,84)(H,73,89)(H,74,90)(H,75,86)(H,76,88)(H,77,91)/b24-19-,32-26+/t31-,33+,34-,35+,36+,37-,38-,41-,42+,43-,46+,47+,48-,49+,50-,51-,52-,53-,65+/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=HQVFHDUBRNXXHV-LZHJWXOHSA-N" RELATED InChIKey [ChEBI:] xref: CiteXplore:16095304 "PubMed citation" xref: CiteXplore:18318032 "PubMed citation" xref: CiteXplore:22223369 "PubMed citation" is_a: CHEBI:26878 ! tertiary alcohol is_a: CHEBI:35213 ! cyclodepsipeptide is_a: CHEBI:35681 ! secondary alcohol is_a: CHEBI:78840 ! olefinic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:83267 name: filipin III namespace: chebi_ontology def: "A macrolide that is the major component of a mixture of four isomeric polyene macrolides isolated from Streptomyces filipinensis." [] synonym: "(3R,4S,6S,8S,10R,12R,14R,16S,17E,19E,21E,23E,25E,27S,28R)-4,6,8,10,12,14,16,27-octahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyloxacyclooctacosa-17,19,21,23,25-pentaen-2-one" EXACT IUPAC_NAME [IUPAC:] synonym: "14-Deoxylagosin" RELATED [ChemIDplus:] synonym: "C35H58O11" RELATED FORMULA [ChEBI:] synonym: "CCCCC[C@@H](O)[C@@H]1[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@H](O)\\C(C)=C\\C=C\\C=C\\C=C\\C=C\\[C@H](O)[C@@H](C)OC1=O" RELATED SMILES [ChEBI:] synonym: "Filimarisin" RELATED [ChemIDplus:] synonym: "Filipin" RELATED [ChemIDplus:] synonym: "filipina" RELATED INN [ChemIDplus:] synonym: "filipine" RELATED INN [ChemIDplus:] synonym: "filipinum" RELATED INN [ChemIDplus:] synonym: "InChI=1S/C35H58O11/c1-4-5-11-16-31(42)34-33(44)22-29(40)20-27(38)18-25(36)17-26(37)19-28(39)21-32(43)23(2)14-12-9-7-6-8-10-13-15-30(41)24(3)46-35(34)45/h6-10,12-15,24-34,36-44H,4-5,11,16-22H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,23-14+/t24-,25+,26-,27+,28-,29+,30+,31-,32+,33+,34-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=IMQSIXYSKPIGPD-YQRUMEKGSA-N" RELATED InChIKey [ChEBI:] xref: ChemIDplus:480-49-9 "CAS Registry Number" xref: CiteXplore:5453318 "PubMed citation" xref: KEGG DRUG:480-49-9 "CAS Registry Number" xref: KEGG DRUG:D04186 "KEGG DRUG" xref: KNApSAcK:C00018791 "KNApSAcK" xref: Reaxys:7326798 "Reaxys Registry Number" is_a: CHEBI:25106 ! macrolide is_a: CHEBI:26191 ! polyol is_a: CHEBI:78840 ! olefinic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:83275 name: hypothemycin namespace: chebi_ontology def: "A macrolide that is isolated from the cultured broth of Hypomyces subiculosus and shows antifungal activity and inhibits the growth of some human cancer cells." [] synonym: "(1aR,8S,10Z,13S,14S,15aR)-5,13,14-trihydroxy-3-methoxy-8-methyl-8,9,13,14,15,15a-hexahydro-6H-oxireno[k][2]benzoxacyclotetradecine-6,12(1aH)-dione" EXACT IUPAC_NAME [IUPAC:] synonym: "C19H22O8" RELATED FORMULA [ChEBI:] synonym: "COc1cc(O)c2c(c1)[C@H]1O[C@@H]1C[C@H](O)[C@H](O)C(=O)\\C=C/C[C@H](C)OC2=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C19H22O8/c1-9-4-3-5-12(20)17(23)14(22)8-15-18(27-15)11-6-10(25-2)7-13(21)16(11)19(24)26-9/h3,5-7,9,14-15,17-18,21-23H,4,8H2,1-2H3/b5-3-/t9-,14-,15+,17+,18+/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=SSNQAUBBJYCSMY-KNTMUCJRSA-N" RELATED InChIKey [ChEBI:] xref: CiteXplore:10421424 "PubMed citation" xref: CiteXplore:10595743 "PubMed citation" xref: CiteXplore:10598882 "PubMed citation" xref: CiteXplore:17691074 "PubMed citation" xref: CiteXplore:18567690 "PubMed citation" xref: CiteXplore:19821460 "PubMed citation" xref: CiteXplore:20118535 "PubMed citation" xref: CiteXplore:20222707 "PubMed citation" xref: CiteXplore:22674780 "PubMed citation" xref: CiteXplore:23853713 "PubMed citation" xref: CiteXplore:24106914 "PubMed citation" xref: CiteXplore:PMC3721247 "PubMed Central citation" xref: Reaxys:6160688 "Reaxys Registry Number" is_a: CHEBI:23824 ! diol is_a: CHEBI:25106 ! macrolide is_a: CHEBI:32955 ! epoxide is_a: CHEBI:33853 ! phenols is_a: CHEBI:35618 ! aromatic ether is_a: CHEBI:51689 ! enone property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:83347 name: organosulfonic ester namespace: chebi_ontology def: "An ester resulting from the formal condensation of the hydroxy group of an alcohol, phenol, heteroarenol, or enol with an organosulfonic acid." [] synonym: "[*]S(=O)(=O)O[*]" RELATED SMILES [ChEBI:] synonym: "O3SR2" RELATED FORMULA [ChEBI:] synonym: "organosulfonate ester" RELATED [ChEBI:] synonym: "organosulfonate esters" RELATED [ChEBI:] synonym: "organosulfonic esters" RELATED [ChEBI:] is_a: CHEBI:33424 ! sulfur oxoacid derivative is_a: CHEBI:35701 ! ester property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:83403 name: monochlorobenzenes namespace: chebi_ontology def: "Any member of the class of chlorobenzenes containing a mono- or poly-substituted benzene ring in which only one substituent is chlorine." [] is_a: CHEBI:23132 ! chlorobenzenes property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:83635 name: guanidinium salt namespace: chebi_ontology def: "An organic salt in which the cation has the structure (RN)2C=N(+)R2." [] synonym: "guanidinium salts" RELATED [ChEBI:] is_a: CHEBI:24868 ! organic salt property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:83811 name: proteinogenic amino acid derivative namespace: chebi_ontology def: "Any derivative of a proteinogenic amino acid resulting from reaction at an amino group, carboxy group, or a side-chain functional group, or from the replacement of any hydrogen by a heteroatom." [] synonym: "canonical amino acid derivative" RELATED [ChEBI:] synonym: "canonical amino acid derivatives" RELATED [ChEBI:] synonym: "canonical amino-acid derivative" RELATED [ChEBI:] synonym: "canonical amino-acid derivatives" RELATED [ChEBI:] synonym: "proteinogenic amino acid derivatives" RELATED [ChEBI:] synonym: "proteinogenic amino-acid derivative" RELATED [ChEBI:] synonym: "proteinogenic amino-acid derivatives" RELATED [ChEBI:] is_a: CHEBI:83821 ! amino acid derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:83813 name: proteinogenic amino acid namespace: chebi_ontology def: "Any of the 23 alpha-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and N-formylmethionine. Apart from glycine, which is non-chiral, all have L configuration." [] synonym: "canonical amino acid" RELATED [ChEBI:] synonym: "canonical amino acids" RELATED [ChEBI:] synonym: "proteinogenic amino acids" RELATED [ChEBI:] xref: Wikipedia:Proteinogenic_amino_acid "Wikipedia" is_a: CHEBI:33575 ! carboxylic acid is_a: CHEBI:35352 ! organonitrogen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:83820 name: non-proteinogenic amino acid namespace: chebi_ontology def: "Any amino-acid that is not naturally encoded in the genetic code of any organism." [] synonym: "non-canonical amino acid" RELATED [ChEBI:] synonym: "non-canonical amino acids" RELATED [ChEBI:] synonym: "non-canonical amino-acid" RELATED [ChEBI:] synonym: "non-canonical amino-acids" RELATED [ChEBI:] synonym: "non-coded amino acid" RELATED [ChEBI:] synonym: "non-coded amino acids" RELATED [ChEBI:] synonym: "non-coded amino-acid" RELATED [ChEBI:] synonym: "non-coded amino-acids" RELATED [ChEBI:] synonym: "non-proteinogenic amino acids" RELATED [ChEBI:] synonym: "non-proteinogenic amino-acid" RELATED [ChEBI:] synonym: "non-proteinogenic amino-acids" RELATED [ChEBI:] xref: Wikipedia:Non-proteinogenic_amino_acids "Wikipedia" is_a: CHEBI:33709 ! amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:83821 name: amino acid derivative namespace: chebi_ontology alt_id: CHEBI:25359 def: "Any derivative of an amino acid resulting from reaction at an amino group, carboxy group, side-chain functional group, or from the replacement of any hydrogen by a heteroatom. The definition normally excludes peptides containing amino acid residues." [] synonym: "amino acid derivatives" RELATED [ChEBI:] synonym: "modified amino acids" RELATED [ChEBI:] is_a: CHEBI:35352 ! organonitrogen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:83822 name: non-proteinogenic L-alpha-amino acid namespace: chebi_ontology def: "Any L-alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids." [] synonym: "non-proteinogenic L-alpha-amino acids" RELATED [ChEBI:] is_a: CHEBI:15705 ! L-alpha-amino acid is_a: CHEBI:83925 ! non-proteinogenic alpha-amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:83824 name: L-cysteine derivative namespace: chebi_ontology def: "A proteinogenic amino acid derivative resulting from the formal reaction of L-cysteine at the amino group, carboxy group, or thiol group, or from the replacement of any hydrogen of L-cysteine by a heteroatom." [] synonym: "L-cysteine derivatives" RELATED [ChEBI:] is_a: CHEBI:23509 ! cysteine derivative is_a: CHEBI:83811 ! proteinogenic amino acid derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:83925 name: non-proteinogenic alpha-amino acid namespace: chebi_ontology def: "Any alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids." [] synonym: "non-proteinogenic alpha-amino acids" RELATED [ChEBI:] synonym: "non-proteinogenic alpha-amino-acid" RELATED [ChEBI:] synonym: "non-proteinogenic alpha-amino-acids" RELATED [ChEBI:] is_a: CHEBI:33704 ! alpha-amino acid is_a: CHEBI:83820 ! non-proteinogenic amino acid property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:84055 name: pentose phosphate namespace: chebi_ontology def: "Any phospho sugar that is the phosphate derivative of pentose." [] synonym: "pentose phosphates" RELATED [ChEBI:] is_a: CHEBI:33447 ! phospho sugar is_a: CHEBI:63409 ! pentose derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:84057 name: trapoxin A namespace: chebi_ontology def: "A homodetic cyclic tetrapeptide constructed from L-phenylalanyl (x2), D-pipecolinyl and L-2-amino-8-oxo-9,10-epoxydecanoyl residues." [] synonym: "(3S,6S,9S,15aR)-6,9-dibenzyl-3-{6-[(2S)-oxiran-2-yl]-6-oxohexyl}octahydro-2H-pyrido[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10(3H,12H)-tetrone" EXACT IUPAC_NAME [IUPAC:] synonym: "C34H42N4O6" RELATED FORMULA [ChEBI:] synonym: "Cyclo((S)-gamma-oxo-L-alpha-aminooxiraneoctanoyl-L-phenylalanyl-L-phenylalanyl-D-2-piperidinecarbonyl)" RELATED [ChemIDplus:] synonym: "Cyclo((S)-phenylalanyl-(S)-phenylalanyl-(R)-pipecolinyl-(2S,9S)-2-amino-8-oxo-9,10-epoxydecanoyl)" RELATED [ChemIDplus:] synonym: "InChI=1S/C34H42N4O6/c39-29(30-22-44-30)18-9-3-8-16-25-31(40)36-26(20-23-12-4-1-5-13-23)32(41)37-27(21-24-14-6-2-7-15-24)34(43)38-19-11-10-17-28(38)33(42)35-25/h1-2,4-7,12-15,25-28,30H,3,8-11,16-22H2,(H,35,42)(H,36,40)(H,37,41)/t25-,26-,27-,28+,30-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=GXVXXETYXSPSOA-UFEOFEBPSA-N" RELATED InChIKey [ChEBI:] synonym: "O=C(CCCCC[C@@H]1NC(=O)[C@H]2CCCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC1=O)[C@@H]1CO1" RELATED SMILES [ChEBI:] synonym: "RF 1023A" RELATED [KNApSAcK:] xref: ChemIDplus:133155-89-2 "CAS Registry Number" xref: CiteXplore:1930826 "PubMed citation" xref: CiteXplore:2276972 "PubMed citation" xref: KNApSAcK:C00017061 "KNApSAcK" xref: Reaxys:8817133 "Reaxys Registry Number" is_a: CHEBI:17087 ! ketone is_a: CHEBI:24613 ! homodetic cyclic peptide is_a: CHEBI:32955 ! epoxide property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:84076 name: L-histidine derivative namespace: chebi_ontology def: "A proteinogenic amino acid derivative resulting from the formal reaction of L-histidine at the amino group, carboxy group, or the imidazolyl moiety, or from the replacement of any hydrogen of L-histidine by a heteroatom." [] synonym: "L-histidine derivatives" RELATED [ChEBI:] is_a: CHEBI:24599 ! histidine derivative is_a: CHEBI:83811 ! proteinogenic amino acid derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:84135 name: L-serine derivative namespace: chebi_ontology def: "A proteinogenic amino acid derivative resulting from reaction of L-serine at the amino group or the carboxy group, or from the replacement of any hydrogen of L-serine by a heteroatom." [] synonym: "L-serine derivatives" RELATED [ChEBI:] is_a: CHEBI:26649 ! serine derivative is_a: CHEBI:83811 ! proteinogenic amino acid derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:84144 name: L-phenylalanine derivative namespace: chebi_ontology def: "A proteinogenic amino acid derivative resulting from reaction of L-phenylalanine at the amino group or the carboxy group, or from the replacement of any hydrogen of L-phenylalanine by a heteroatom." [] synonym: "L-phenylalanine derivatives" RELATED [ChEBI:] is_a: CHEBI:25985 ! phenylalanine derivative is_a: CHEBI:83811 ! proteinogenic amino acid derivative property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:84327 name: torin 1 namespace: chebi_ontology def: "A member of the class of pyridoquinolines that is 9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2-one bearing an additional 4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl substituent at position 1." [] synonym: "1-[4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl]-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one" EXACT IUPAC_NAME [IUPAC:] synonym: "C35H28F3N5O2" RELATED FORMULA [ChEBI:] synonym: "CCC(=O)N1CCN(CC1)c1ccc(cc1C(F)(F)F)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1cnc2ccccc2c1" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C35H28F3N5O2/c1-2-32(44)42-15-13-41(14-16-42)31-11-9-26(19-28(31)35(36,37)38)43-33(45)12-8-24-20-40-30-10-7-22(18-27(30)34(24)43)25-17-23-5-3-4-6-29(23)39-21-25/h3-12,17-21H,2,13-16H2,1H3" RELATED InChI [ChEBI:] synonym: "InChIKey=AKCRNFFTGXBONI-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "torin1" RELATED [ChEBI:] xref: CiteXplore:20860370 "PubMed citation" xref: CiteXplore:24424027 "PubMed citation" xref: CiteXplore:25339775 "PubMed citation" xref: Reaxys:20268275 "Reaxys Registry Number" is_a: CHEBI:26513 ! quinolines is_a: CHEBI:36820 ! ring assembly is_a: CHEBI:37143 ! organofluorine compound is_a: CHEBI:38921 ! pyridoquinoline is_a: CHEBI:46844 ! N-acylpiperazine is_a: CHEBI:46848 ! N-arylpiperazine property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:84333 name: synthalin namespace: chebi_ontology def: "A hydrochloride resulting from the reaction of decamethylenediguanidine with 2 mol eq. of hydrogen chloride." [] synonym: "(decane-1,10-diyldiimino)bis(iminomethanaminium) dichloride" EXACT IUPAC_NAME [IUPAC:] synonym: "1,1'-Decamethylenediguanidine dihydrochloride" RELATED [ChemIDplus:] synonym: "1,1'-decane-1,10-diyldiguanidine dihydrochloride" EXACT IUPAC_NAME [IUPAC:] synonym: "1,10-bis(guanidino)decane dihydrochloride" RELATED [ChEBI:] synonym: "C12H30Cl2N6" RELATED FORMULA [ChEBI:] synonym: "Cl.Cl.NC(=N)NCCCCCCCCCCNC(N)=N" RELATED SMILES [ChEBI:] synonym: "Decamethylenediguanidine dihydrochloride" RELATED [ChemIDplus:] synonym: "decamethylenediguanidine hydrochloride" RELATED [ChEBI:] synonym: "Decanediguanidine dihydrochloride" RELATED [ChemIDplus:] synonym: "InChI=1S/C12H28N6.2ClH/c13-11(14)17-9-7-5-3-1-2-4-6-8-10-18-12(15)16;;/h1-10H2,(H4,13,14,17)(H4,15,16,18);2*1H" RELATED InChI [ChEBI:] synonym: "InChIKey=HJJOBGICUREWHC-UHFFFAOYSA-N" RELATED InChIKey [ChEBI:] synonym: "N,N'''-1,10-Decanediylbisguanadine dihydrochloride" RELATED [ChemIDplus:] synonym: "Synthalin A dihydrochloride" RELATED [ChemIDplus:] synonym: "Synthalin dihydrochloride" RELATED [ChemIDplus:] xref: ChemIDplus:301-15-5 "CAS Registry Number" xref: CiteXplore:12981621 "PubMed citation" xref: CiteXplore:13152613 "PubMed citation" xref: CiteXplore:13202402 "PubMed citation" xref: CiteXplore:13203057 "PubMed citation" xref: CiteXplore:13246651 "PubMed citation" xref: CiteXplore:13256516 "PubMed citation" xref: CiteXplore:13277489 "PubMed citation" xref: CiteXplore:13375597 "PubMed citation" xref: CiteXplore:13561982 "PubMed citation" xref: CiteXplore:13576297 "PubMed citation" xref: CiteXplore:13576350 "PubMed citation" xref: CiteXplore:16993940 "PubMed citation" xref: CiteXplore:17781266 "PubMed citation" xref: CiteXplore:20316715 "PubMed citation" xref: CiteXplore:20776682 "PubMed citation" xref: CiteXplore:234241 "PubMed citation" xref: CiteXplore:5681420 "PubMed citation" xref: CiteXplore:6350026 "PubMed citation" xref: Reaxys:3917166 "Reaxys Registry Number" xref: Wikipedia:Synthalin "Wikipedia" is_a: CHEBI:36807 ! hydrochloride is_a: CHEBI:83635 ! guanidinium salt property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:84340 name: hydrazinocurcumin namespace: chebi_ontology def: "A pyrazole obtained by cyclocodensation of the two carbonyl groups of curcumin with hydrazine." [] synonym: "4,4'-[1H-pyrazole-3,5-diyldi(E)ethene-2,1-diyl]bis(2-methoxyphenol)" EXACT IUPAC_NAME [IUPAC:] synonym: "C21H20N2O4" RELATED FORMULA [ChEBI:] synonym: "COc1cc(\\C=C\\c2cc(\\C=C\\c3ccc(O)c(OC)c3)[nH]n2)ccc1O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C21H20N2O4/c1-26-20-11-14(5-9-18(20)24)3-7-16-13-17(23-22-16)8-4-15-6-10-19(25)21(12-15)27-2/h3-13,24-25H,1-2H3,(H,22,23)/b7-3+,8-4+" RELATED InChI [ChEBI:] synonym: "InChIKey=LKLASFRCXLTNMY-FCXRPNKRSA-N" RELATED InChIKey [ChEBI:] synonym: "pyrazole-curcumin" RELATED [ChEBI:] xref: CiteXplore:12057633 "PubMed citation" xref: CiteXplore:12110321 "PubMed citation" xref: CiteXplore:17988818 "PubMed citation" xref: CiteXplore:18309270 "PubMed citation" xref: CiteXplore:20797619 "PubMed citation" xref: CiteXplore:22179587 "PubMed citation" xref: CiteXplore:22989913 "PubMed citation" xref: CiteXplore:23825527 "PubMed citation" xref: CiteXplore:24716943 "PubMed citation" xref: Reaxys:4271395 "Reaxys Registry Number" is_a: CHEBI:26195 ! polyphenol is_a: CHEBI:26410 ! pyrazoles is_a: CHEBI:35618 ! aromatic ether is_a: CHEBI:78840 ! olefinic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:84688 name: Fe(III)-complexed hydroxamate siderophore namespace: chebi_ontology def: "Any iron(III) hydroxamate in which the hydroxamate component is a siderophore." [] synonym: "Fe(III)-complexed hydroxamate siderophores" RELATED [ChEBI:] synonym: "Fe(III)-hydroxamate siderophore" RELATED [ChEBI:] synonym: "Fe(III)-hydroxamate siderophores" RELATED [ChEBI:] synonym: "ferric-hydroxamate type siderophore" RELATED [ChEBI:] synonym: "ferric-hydroxamate type siderophores" RELATED [ChEBI:] is_a: CHEBI:28163 ! iron(III) hydroxamate is_a: CHEBI:84734 ! Fe(III)-complexed siderophore property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:84734 name: Fe(III)-complexed siderophore namespace: chebi_ontology def: "Any iron chelate that consists of a siderophore complexed to iron(III)" [] synonym: "Fe(III)-complexed siderophores" RELATED [ChEBI:] synonym: "Fe(III)-siderophore" RELATED [ChEBI:] synonym: "Fe(III)-siderophores" RELATED [ChEBI:] synonym: "ferric siderophore" RELATED [ChEBI:] synonym: "ferric siderophores" RELATED [ChEBI:] is_a: CHEBI:5975 ! iron chelate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:8984 name: sodium dodecyl sulfate namespace: chebi_ontology def: "An alkyl sulfate that has formula C12H25NaO4S." [] synonym: "[Na+].CCCCCCCCCCCCOS([O-])(=O)=O" RELATED SMILES [ChEBI:] synonym: "C12H25NaO4S" RELATED FORMULA [ChEBI:] synonym: "C12H25O4S.Na" RELATED FORMULA [KEGG COMPOUND:] synonym: "InChI=1S/C12H26O4S.Na/c1-2-3-4-5-6-7-8-9-10-11-12-16-17(13,14)15;/h2-12H2,1H3,(H,13,14,15);/q;+1/p-1" RELATED InChI [ChEBI:] synonym: "InChIKey=DBMJMQXJHONAFJ-UHFFFAOYSA-M" RELATED InChIKey [ChEBI:] synonym: "SDS" RELATED [KEGG COMPOUND:] synonym: "SLS" RELATED [ChemIDplus:] synonym: "Sodium dodecyl sulfate" EXACT [KEGG COMPOUND:] synonym: "sodium dodecyl sulphate" RELATED [ChemIDplus:] synonym: "sodium dodecylsulfate" RELATED [ChemIDplus:] synonym: "Sodium lauryl sulfate" RELATED [KEGG COMPOUND:] synonym: "sodium lauryl sulphate" RELATED [ChemIDplus:] xref: Beilstein:3599286 "Beilstein Registry Number" xref: ChemIDplus:151-21-3 "CAS Registry Number" xref: DrugBank:DB00815 "DrugBank" xref: Gmelin:117722 "Gmelin Registry Number" xref: KEGG COMPOUND:151-21-3 "CAS Registry Number" xref: KEGG COMPOUND:C11166 "KEGG COMPOUND" xref: KEGG DRUG:D01045 "KEGG DRUG" is_a: CHEBI:29281 ! alkyl sulfate property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:9168 name: sirolimus namespace: chebi_ontology alt_id: CHEBI:67812 def: "A macrolide isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent." [] synonym: "(-)-Rapamycin" RELATED [ChemIDplus:] synonym: "(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-{(2S)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0(4,9)]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone" RELATED [IUPAC:] synonym: "(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone" EXACT IUPAC_NAME [IUPAC:] synonym: "23,27-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine" RELATED [ChEBI:] synonym: "[H][C@]1(CC[C@@H](O)[C@@H](C1)OC)C[C@@H](C)[C@]1([H])CC(=O)[C@H](C)\\C=C(C)\\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\\C=C\\C=C\\C=C(C)\\[C@H](C[C@]2([H])CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@@]2([H])C(=O)O1)OC" RELATED SMILES [ChEBI:] synonym: "Antibiotic AY 22989" RELATED [DrugBank:] synonym: "C51H79NO13" RELATED FORMULA [ChEBI:] synonym: "InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=QFJCIRLUMZQUOT-HPLJOQBZSA-N" RELATED InChIKey [ChEBI:] synonym: "Perceiva" RELATED [ChEBI:] synonym: "Rapamune" RELATED BRAND_NAME [DrugBank:] synonym: "Rapamune" RELATED [ChEBI:] synonym: "rapamycin" RELATED [ChEBI:] synonym: "Sirolimu" RELATED [ChEBI:] synonym: "Sirolimus" EXACT [KEGG COMPOUND:] synonym: "sirolimus" RELATED INN [WHO MedNet:] synonym: "sirolimusum" RELATED INN [WHO MedNet:] xref: ChemIDplus:53123-88-9 "CAS Registry Number" xref: CiteXplore:21438579 "PubMed citation" xref: CiteXplore:22960739 "PubMed citation" xref: CiteXplore:22981852 "PubMed citation" xref: CiteXplore:22984623 "PubMed citation" xref: DrugBank:DB00877 "DrugBank" xref: HMDB:HMDB15015 "HMDB" xref: KEGG COMPOUND:53123-88-9 "CAS Registry Number" xref: KEGG COMPOUND:C07909 "KEGG COMPOUND" xref: KEGG DRUG:D00753 "KEGG DRUG" xref: KNApSAcK:C00018055 "KNApSAcK" xref: LIPID MAPS:LMPK06000003 "LIPID MAPS instance" xref: PDBeChem:RAP "PDBeChem" xref: Reaxys:5848501 "Reaxys Registry Number" xref: Wikipedia:Rapamycin "Wikipedia" is_a: CHEBI:24995 ! lactam is_a: CHEBI:25106 ! macrolide is_a: CHEBI:25698 ! ether is_a: CHEBI:35681 ! secondary alcohol is_a: CHEBI:3992 ! cyclic ketone is_a: CHEBI:59770 ! cyclic acetal property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:9448 name: terbinafine namespace: chebi_ontology def: "A tertiary amine that is N-methyl-1-naphthalenemethylamine in which the amino hydrogen is replaced by a 3-(tertbutylethynyl)allyl group. An antifungal agent administered orally (generally as the hydrochloride salt) for the treatment of skin and nail infections." [] synonym: "(2E)-N,6,6-trimethyl-N-(1-naphthylmethyl)hept-2-en-4-yn-1-amine" EXACT IUPAC_NAME [IUPAC:] synonym: "(E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalene methanamine" RELATED [ChemIDplus:] synonym: "(E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethylamine" RELATED [ChemIDplus:] synonym: "C21H25N" RELATED FORMULA [ChEBI:] synonym: "CN(C\\C=C\\C#CC(C)(C)C)Cc1cccc2ccccc12" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C21H25N/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19/h5-7,9-14H,16-17H2,1-4H3/b9-5+" RELATED InChI [ChEBI:] synonym: "InChIKey=DOMXUEMWDBAQBQ-WEVVVXLNSA-N" RELATED InChIKey [ChEBI:] synonym: "terbinafina" RELATED INN [WHO MedNet:] synonym: "Terbinafine" EXACT [KEGG COMPOUND:] synonym: "terbinafine" EXACT [WHO MedNet:] synonym: "terbinafine" RELATED INN [KEGG DRUG:] synonym: "terbinafinum" RELATED INN [WHO MedNet:] xref: ChemIDplus:91161-71-6 "CAS Registry Number" xref: CiteXplore:23750489 "PubMed citation" xref: CiteXplore:23802806 "PubMed citation" xref: CiteXplore:23841559 "PubMed citation" xref: CiteXplore:23895037 "PubMed citation" xref: CiteXplore:24126579 "PubMed citation" xref: CiteXplore:24352873 "PubMed citation" xref: CiteXplore:24389279 "PubMed citation" xref: CiteXplore:24410098 "PubMed citation" xref: CiteXplore:24447130 "PubMed citation" xref: CiteXplore:24452843 "PubMed citation" xref: CiteXplore:24477462 "PubMed citation" xref: CiteXplore:24490976 "PubMed citation" xref: CiteXplore:24497012 "PubMed citation" xref: CiteXplore:24533442 "PubMed citation" xref: CiteXplore:24563892 "PubMed citation" xref: CiteXplore:24576265 "PubMed citation" xref: CiteXplore:24581620 "PubMed citation" xref: CiteXplore:24588014 "PubMed citation" xref: DrugBank:DB00857 "DrugBank" xref: HMDB:HMDB14995 "HMDB" xref: KEGG COMPOUND:91161-71-6 "CAS Registry Number" xref: KEGG COMPOUND:C08079 "KEGG COMPOUND" xref: KEGG DRUG:D02375 "KEGG DRUG" xref: MetaCyc:CPD-10571 "MetaCyc" xref: Reaxys:4256376 "Reaxys Registry Number" xref: Wikipedia:Terbinafine "Wikipedia" is_a: CHEBI:25477 ! naphthalenes is_a: CHEBI:32876 ! tertiary amine is_a: CHEBI:59831 ! enyne property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:9602 name: Tingenone namespace: chebi_ontology def: "A cyclohexanone that has formula C28H36O3." [] synonym: "C28H36O3" RELATED FORMULA [KEGG COMPOUND:] synonym: "C[C@@H]1C[C@@H]2[C@@](C)(CC[C@@]3(C)C4=CC=C5C(C)=C(O)C(=O)C=C5[C@]4(C)CC[C@]23C)CC1=O" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C28H36O3/c1-16-13-23-25(3,15-21(16)30)9-11-27(5)22-8-7-18-17(2)24(31)20(29)14-19(18)26(22,4)10-12-28(23,27)6/h7-8,14,16,23,31H,9-13,15H2,1-6H3/t16-,23-,25+,26+,27+,28-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=WSTYNZDAOAEEKG-QSPBTJQRSA-N" RELATED InChIKey [ChEBI:] synonym: "Tingenone" EXACT [KEGG COMPOUND:] xref: KEGG COMPOUND:50802-21-6 "CAS Registry Number" xref: KEGG COMPOUND:C08638 "KEGG COMPOUND" xref: KNApSAcK:C00003759 "KNApSAcK" is_a: CHEBI:23482 ! cyclohexanones property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:9642 name: N-tosyl-L-phenylalanyl chloromethyl ketone namespace: chebi_ontology def: "The N-tosyl derivative of L-phenylalanyl chloromethyl ketone." [] synonym: "C17H18ClNO3S" RELATED FORMULA [KEGG COMPOUND:] synonym: "Cc1ccc(cc1)S(=O)(=O)N[C@@H](Cc1ccccc1)C(=O)CCl" RELATED SMILES [ChEBI:] synonym: "InChI=1S/C17H18ClNO3S/c1-13-7-9-15(10-8-13)23(21,22)19-16(17(20)12-18)11-14-5-3-2-4-6-14/h2-10,16,19H,11-12H2,1H3/t16-/m0/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=MQUQNUAYKLCRME-INIZCTEOSA-N" RELATED InChIKey [ChEBI:] synonym: "L-1-Tosylamido-2-phenylethyl chloromethyl ketone" RELATED [ChemIDplus:] synonym: "l-N-(alpha-(Chloroacetyl)phenethyl)-p-toluenesulfonamide" RELATED [ChemIDplus:] synonym: "N-[(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]-4-methylbenzenesulfonamide" EXACT IUPAC_NAME [IUPAC:] synonym: "N-Tosyl-L-phenylalanine chloromethyl ketone" RELATED [ChemIDplus:] synonym: "N-Tosyl-L-phenylalanyl chloromethyl ketone" EXACT [KEGG COMPOUND:] synonym: "Tos-Phe-CH2Cl" RELATED [KEGG COMPOUND:] synonym: "Tosylphenylalanyl chloromethyl ketone" RELATED [ChemIDplus:] synonym: "TPCK" RELATED [KEGG COMPOUND:] xref: Beilstein:6895141 "Beilstein Registry Number" xref: ChemIDplus:402-71-1 "CAS Registry Number" xref: KEGG COMPOUND:402-71-1 "CAS Registry Number" xref: KEGG COMPOUND:C02088 "KEGG COMPOUND" is_a: CHEBI:35358 ! sulfonamide is_a: CHEBI:51841 ! alpha-chloroketone property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CHEBI:9688 name: trichodermin namespace: chebi_ontology alt_id: CHEBI:552470 def: "A tetracyclic spiroepoxide which acts as an antifungal and protein synthesis inhibitor." [] synonym: "(4beta,12R)-12,13-epoxytrichothec-9-en-4-yl acetate" EXACT IUPAC_NAME [IUPAC:] synonym: "12,13-Epoxytrichothec-9-en-4-ol acetate" RELATED [ChemIDplus:] synonym: "[H][C@]12C[C@@H](OC(C)=O)[C@](C)([C@@]3(C)CCC(C)=C[C@@]3([H])O1)[C@@]21CO1" RELATED SMILES [ChEBI:] synonym: "C17H24O4" RELATED FORMULA [KEGG COMPOUND:] synonym: "InChI=1S/C17H24O4/c1-10-5-6-15(3)12(7-10)21-14-8-13(20-11(2)18)16(15,4)17(14)9-19-17/h7,12-14H,5-6,8-9H2,1-4H3/t12-,13-,14-,15+,16-,17-/m1/s1" RELATED InChI [ChEBI:] synonym: "InChIKey=HNEGCRMUYSKRRR-NWHWRWDZSA-N" RELATED InChIKey [ChEBI:] synonym: "Trichodermin" EXACT [KEGG COMPOUND:] xref: Beilstein:6868411 "Beilstein Registry Number" xref: ChemIDplus:4682-50-2 "CAS Registry Number" xref: CiteXplore:4750433 "PubMed citation" xref: CiteXplore:6757231 "PubMed citation" xref: KEGG COMPOUND:4682-50-2 "CAS Registry Number" xref: KEGG COMPOUND:C09741 "KEGG COMPOUND" xref: KNApSAcK:C00003195 "KNApSAcK" xref: Patent:NL302527 "Patent" is_a: CHEBI:32955 ! epoxide is_a: CHEBI:38163 ! organic heterotetracyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/chebi.owl [Term] id: CL:0000000 name: cell namespace: cell def: "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane." [CARO:mah] comment: The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one). subset: ubprop:upper_level xref: CALOHA:TS-2035 xref: FMA:68646 xref: GO:0005623 xref: KUPO:0000002 xref: VHOG:0001533 xref: WBbt:0004017 xref: XAO:0003012 property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl/cl-basic.owl [Term] id: CL:0000003 name: native cell namespace: cell def: "A cell that is found in a natural setting, which includes multicellular organism cells 'in vivo' (i.e. part of an organism), and unicellular organisms 'in environment' (i.e. part of a natural environment)." [CARO:mah] comment: To accommodate unicellular organisms better, 'cell in vivo' has been re-labeled 'native cell' to better represent its intended meaning - that is, that it is a cell in the context of a multicellular organism or in a natural environment. 'Native' is intended to contrast with 'in vitro', which refers to cells or other biological entities that have been intentionally placed in a controlled, non-natural setting for the purpose of study or manipulation. (MAH 1.12.12). subset: ubprop:upper_level synonym: "cell in vivo" NARROW [] xref: CARO:0000013 is_a: CL:0000000 ! cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl/cl-basic.owl [Term] id: CL:0000255 name: eukaryotic cell namespace: cell is_a: CL:0000003 ! native cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl/cl-basic.owl [Term] id: CL:0000334 name: vegetative cell (sensu Fungi) namespace: cell synonym: "yeast-form" RELATED [] xref: BTO:0002307 xref: FAO:0000032 is_a: CL:0000521 ! fungal cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl/cl-basic.owl [Term] id: CL:0000521 name: fungal cell namespace: cell is_a: CL:0000255 ! eukaryotic cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl/cl-basic.owl [Term] id: CL:0000596 name: sexual spore namespace: cell def: "A spore formed following meiosis. Sometimes following meiosis, prospores may undergo one or more rounds of mitosis before they are fully mature." [FAO:0000017, GOC:tfm, SGD:clt] synonym: "meiotically-derived spore" EXACT [] xref: FAO:0000017 is_a: CL:0002369 ! fungal spore property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl/cl-basic.owl [Term] id: CL:0002369 name: fungal spore namespace: cell def: "A differentiated form of a fungus produced during or as a result of an asexual or sexual reproductive process; usually a cell with a thick cell wall that stores and protects one or more nuclei. Spores may be produced in response to, and are characteristically resistant to, adverse environmental conditions." [FAO:0000019, GOC:tfm] is_a: CL:0000521 ! fungal cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl/cl-basic.owl created_by: tmeehan creation_date: 2010-10-01T09:02:42Z [Term] id: CL:0002674 name: H minus namespace: cell def: "A S. pombe mating type determined by the mat1-Mc and mat1-Mi on the mat1 locus." [GOC:tfm] synonym: "H- cell" EXACT [] is_a: CL:0000521 ! fungal cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl/cl-basic.owl created_by: tmeehan creation_date: 2011-08-16T03:20:53Z [Term] id: CL:0002675 name: H plus namespace: cell def: "A S. pombe cell type determined by mat1-Pc and mat1-Pi on the mat1 locus." [GOC:tfm] is_a: CL:0000521 ! fungal cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl/cl-basic.owl created_by: tmeehan creation_date: 2011-08-16T03:20:58Z [Term] id: FYPO:0000001 name: phenotype def: "Any of the set of observable characteristics of an organism resulting from the interaction of its genotype with the environment." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast phenotype" EXACT [PomBase:mah] creation_date: 2011-03-16T03:59:25Z [Term] id: FYPO:0000002 name: cell phenotype def: "A phenotype that is observed at the level of an individual cell." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast cell phenotype" EXACT [PomBase:mah] is_a: FYPO:0000001 ! phenotype intersection_of: FYPO:0000001 ! phenotype intersection_of: inheres_in_part_of GO:0005575 ! cellular_component disjoint_from: FYPO:0000003 ! cell population phenotype relationship: inheres_in_part_of GO:0005575 ! cellular_component created_by: midori creation_date: 2011-03-16T04:25:28Z [Term] id: FYPO:0000003 name: cell population phenotype def: "A phenotype that is observed at the level of a population of cells." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. Note: differentium is population level, and may reflect observation conditions. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast cell population phenotype" EXACT [PomBase:mah] is_a: FYPO:0000001 ! phenotype created_by: midori creation_date: 2011-03-16T04:26:35Z [Term] id: FYPO:0000004 name: cell viability def: "A cell phenotype that consists of the cell's disposition to survive and develop normally." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. Viability is usually determined under standard laboratory conditions, i.e. a cell is generally considered viable if it can grow in rich medium under normal conditions such as temperature, pressure, oxygen level, pH, etc. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_a: FYPO:0000136 ! cellular physical quality phenotype is_a: PATO:0000169 ! viability intersection_of: PATO:0000169 ! viability intersection_of: inheres_in CL:0000000 ! cell relationship: inheres_in CL:0000000 ! cell created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000005 name: abnormal cell morphology alt_id: FYPO:0000019 def: "A cell phenotype characterized by altered cell morphology, i.e. the size, shape, or structure of the cell is abnormal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "cell morphology, misshapen cells" RELATED [PomBase:mah] synonym: "cellular morphology: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0003037 ! abnormal cell phenotype is_a: FYPO:0004638 ! abnormal cellular physical quality phenotype is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: inheres_in CL:0000000 ! cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in CL:0000000 ! cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000006 name: abnormal DNA damage checkpoint def: "A cell cycle checkpoint phenotype in which any DNA damage checkpoint is abnormal. A DNA damage checkpoint normally regulates progression through the cell cycle in response to DNA damage. In a mutant, the checkpoint may fail to arrest or delay cell cycle progression under appropriate conditions, or the incidence or duration of arrest or delay may differ from wild type under any specified set of conditions." [PomBase:mah] synonym: "abnormal DNA damage checkpoint activation" EXACT [PomBase:mah] synonym: "abnormal DNA damage checkpoint during cellular response to DNA damage" EXACT [PomBase:al] synonym: "abnormal DNA damage checkpoint during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal DNA damage checkpoint during vegetative growth" EXACT [PomBase:mah] synonym: "DNA damage checkpoint defects" EXACT [PomBase:mah] is_a: FYPO:0000157 ! abnormal response to DNA damage stimulus is_a: FYPO:0000643 ! abnormal mitotic DNA integrity checkpoint intersection_of: PATO:0000001 ! quality intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000077 ! DNA damage checkpoint intersection_of: qualifier PATO:0000460 ! abnormal relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000077 ! DNA damage checkpoint relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000007 name: abnormal S-phase DNA damage checkpoint alt_id: FYPO:0000195 def: "A cell cycle checkpoint phenotype in which the S phase DNA damage checkpoint (also known as the intra-S phase DNA damage checkpoint) is abnormal. The S phase DNA damage checkpoint slows progression through S phase in response to DNA damage. In a mutant, the checkpoint may fail to arrest or delay cell cycle progression under appropriate conditions, or the incidence or duration of arrest or delay may differ from wild type under any specified set of conditions." [PomBase:mah] synonym: "abnormal intra-S DNA damage checkpoint" EXACT [PomBase:mah] synonym: "abnormal S-phase DNA damage checkpoint activation" RELATED [PomBase:mah] synonym: "abnormal S-phase DNA damage checkpoint during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal S-phase DNA damage checkpoint during vegetative growth" EXACT [PomBase:mah] synonym: "DNA damage checkpoint defects, S-phase" EXACT [PomBase:mah] is_a: FYPO:0000006 ! abnormal DNA damage checkpoint intersection_of: PATO:0000001 ! quality intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0031573 ! intra-S DNA damage checkpoint intersection_of: qualifier PATO:0000460 ! abnormal relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0031573 ! intra-S DNA damage checkpoint relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000008 name: abnormal meiotic recombination def: "A cellular process phenotype in which reciprocal meiotic recombination is abnormal. Meiotic recombination is a cellular process in which double strand breaks are formed and repaired through a double Holliday junction intermediate, resulting in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes." [GO:0007131, PomBase:mah] synonym: "abnormal meiotic DNA recombination" EXACT [PomBase:mah] synonym: "abnormal reciprocal meiotic recombination" EXACT [PomBase:mah] synonym: "DNA recombination defects, meiotic" EXACT [PomBase:mah] synonym: "meiotic recombination: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000063 ! abnormal DNA recombination is_a: FYPO:0002739 ! abnormal meiotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0007131 ! reciprocal meiotic recombination intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0007131 ! reciprocal meiotic recombination relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000009 name: abnormal cell adhesion during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which adhesion of a cell to a substrate or another cell is abnormal." [PomBase:mah] synonym: "abnormal cell adhesion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "adhesion defects during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0001872 ! abnormal cell adhesion intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0007155 ! cell adhesion intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0007155 ! cell adhesion relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000010 name: abolished cell-substrate adhesion def: "A cell adhesion phenotype observed in the vegetative growth phase of the life cycle in which cells fail to adhere to a substrate." [PomBase:mah] synonym: "abolished cell-substrate adhesion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "cell-substrate adhesion abolished" EXACT [PomBase:mah] synonym: "cell-substrate adhesion abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000009 ! abnormal cell adhesion during vegetative growth is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0031589 ! cell-substrate adhesion relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0031589 ! cell-substrate adhesion created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000011 name: abnormal cell cycle alt_id: FYPO:0000406 def: "A cellular process phenotype in which a cell does not proceed normally through a cell cycle." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "abnormal cell-division cycle" EXACT [GO:0007049, PomBase:mah] synonym: "cell cycle defects" EXACT [PomBase:mah] synonym: "cell cycle progression: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000628 ! abnormal cellular process is_a: FYPO:0000631 ! cell cycle phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0007049 ! cell cycle intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0007049 ! cell cycle relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000012 name: mitotic G2/M transition delay alt_id: FYPO:0000205 alt_id: FYPO:0000401 alt_id: FYPO:0000604 alt_id: FYPO:0000605 alt_id: FYPO:0000606 alt_id: FYPO:0000971 def: "A cell cycle phenotype in which the G2/M transition of the mitotic cell cycle begins later than normal. The duration of G2 phase is thus longer than normal." [PomBase:mah] comment: A G2/M delay may indicate that a checkpoint, such as the DNA replication checkpoint or the G2/M DNA damage checkpoint, is activated. Checkpoint activation can be tested using checkpoint kinase mutants. synonym: "cell cycle progression through the G2/M phase transition: delayed" EXACT [SGD:phenotype_annotation] synonym: "cell cycle, mitotic G2 delay" RELATED [PomBase:mah] synonym: "decreased rate of mitotic G2 phase progression" RELATED [PomBase:mah] synonym: "delayed cell cycle progression through mitotic G2/M phase transition" EXACT [PomBase:mah] synonym: "delayed entry into mitosis" EXACT [PomBase:vw] synonym: "delayed mitotic entry" EXACT [PomBase:vw] synonym: "delayed mitotic G2 phase progression" RELATED [PomBase:mah] synonym: "delayed onset of mitotic M phase" RELATED [PomBase:vw] synonym: "increased duration of mitotic G2 phase" RELATED [PomBase:mah] synonym: "increased duration of mitotic G2 phase during vegetative growth" RELATED [PomBase:mah] synonym: "increased mitotic G2 duration" RELATED [PomBase:mah] synonym: "mitotic cell cycle delay at G2/M transition" EXACT [PomBase:mah] synonym: "mitotic cell cycle progression in G2 phase: decreased rate" RELATED [SGD:phenotype_annotation] synonym: "mitotic cell cycle progression in G2 phase: delayed" RELATED [SGD:phenotype_annotation] synonym: "mitotic cell cycle progression in G2 phase: increased duration" RELATED [SGD:phenotype_annotation] synonym: "mitotic DNA replication checkpoint activated" RELATED [PomBase:mah] synonym: "mitotic G2 delay" RELATED [PomBase:mah] synonym: "mitotic G2/M transition delay during vegetative growth" EXACT [PomBase:mah] synonym: "mitotic G2/M transition DNA damage checkpoint activated" RELATED [PomBase:mah] synonym: "reduced rate of mitotic G2 phase progression" RELATED [PomBase:mah] is_a: FYPO:0000399 ! abnormal mitotic G2/M phase transition is_a: FYPO:0000409 ! delayed cell cycle phase transition is_a: FYPO:0000563 ! abnormal mitotic G2 phase progression is_a: FYPO:0001069 ! increased duration of mitotic cell cycle phase intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000086 ! G2/M transition of mitotic cell cycle relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000086 ! G2/M transition of mitotic cell cycle created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000013 name: T-shaped vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a new growth zone forms along the lateral portion of the cell (often in the middle) before septation, such that a single cell grows in the form of the letter T. Cell length is normal." [PomBase:mah, PomBase:vw] comment: A T-shaped cell may septate perpendicular to the normal septation axis, and divide to form normal-shaped daughter cells. Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "cell morphology, T shaped" EXACT [PomBase:mah] synonym: "T-shaped cell" BROAD [PomBase:mah] synonym: "T-shaped cell during vegetative growth" EXACT [PomBase:mah] synonym: "T-shaped vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000015 ! branched vegetative cell is_a: FYPO:0002197 ! viable vegetative cell with abnormal cell shape created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000014 name: tapered cell def: "A cell morphology phenotype in which the cell tapers at one end to a diameter smaller than the other. The cell diameter at the narrow end is smaller than that of a wild-type cell." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "bottle-shaped cell" EXACT [PomBase:vw] synonym: "cell morphology, bottle/skittle" EXACT [PomBase:mah] synonym: "skittle-shaped cell" EXACT [PomBase:mah] is_a: FYPO:0001126 ! abnormal cell shape is_a: PATO:0002213 ! obclavate intersection_of: PATO:0002213 ! obclavate intersection_of: inheres_in CL:0000000 ! cell relationship: inheres_in CL:0000000 ! cell created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000015 name: branched vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a daughter cell begins to grow from the lateral portion of the long axis of the cell, and at an angle to the septum or cell division site of the mother cell, resulting in the formation of a single cell that has a branch." [PomBase:mah] subset: qc_do_not_manually_annotate synonym: "branched cell" EXACT [PomBase:mah] synonym: "branched cell during vegetative growth" EXACT [PomBase:mah] synonym: "branched vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "cell morphology, branched" EXACT [PomBase:mah] is_a: FYPO:0002196 ! abnormal vegetative cell shape is_a: PATO:0000402 ! branched intersection_of: PATO:0000402 ! branched intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000016 name: curved vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is curved along the long axis. In a curved cell, the long axis follows a smooth bend rather than a straight line." [PomBase:mah] synonym: "cell morphology, curved" EXACT [PomBase:mah] synonym: "comma-shaped cell" EXACT [PomBase:vw] synonym: "curved cell" EXACT [PomBase:mah] synonym: "curved cell during vegetative growth" EXACT [PomBase:mah] synonym: "curved vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0002196 ! abnormal vegetative cell shape is_a: PATO:0000406 ! curved intersection_of: PATO:0000406 ! curved intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000017 name: elongated cell def: "A cell morphology phenotype in which cells are longer than normal, i.e. the maximum distance between the cell ends is greater than normal." [PomBase:mah, PomBase:vw] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. Note that this term is classified as a type of abnormal cell shape, because wild-type cells are never seen with the proportions (length:width ratio) observed in elongated cells. Small cells, in contrast, have the same proportions as a subset of wild-type cells, and simply do not grow to the full length seen in wild type. subset: qc_do_not_manually_annotate synonym: "cell morphology, elongated cell" EXACT [PomBase:mah] synonym: "long cell" EXACT [PomBase:vw] is_a: FYPO:0001126 ! abnormal cell shape is_a: FYPO:0001127 ! abnormal cell size is_a: PATO:0000573 ! increased length intersection_of: PATO:0000573 ! increased length intersection_of: inheres_in CL:0000000 ! cell relationship: inheres_in CL:0000000 ! cell created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000020 name: pear-shaped cell def: "A cell morphology phenotype in which a cell is shaped in the form of a pear. One end is rounded, while the other resembles an end of a normal rod-shaped cell. The normally shaped end has the same diameter as a wild-type cell." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "cell morphology, pear shaped" EXACT [PomBase:mah] synonym: "ice cream cone-shaped cell" EXACT [PMID:2236039, PomBase:vw] is_a: FYPO:0001126 ! abnormal cell shape is_a: PATO:0002240 ! teardrop-shaped intersection_of: PATO:0002240 ! teardrop-shaped intersection_of: inheres_in CL:0000000 ! cell relationship: inheres_in CL:0000000 ! cell created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000021 name: spheroid vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is shaped in the form of a spheroid. In spheroid cells, there is much less difference between the long and short axes of the cell than in wild type. Spheroid cells may shorter than normal, with approximately the same diameter as normal, or they may be enlarged." [PomBase:mah] synonym: "cell morphology, round vegetative cell" RELATED [PomBase:mah] synonym: "cell morphology, rounded vegetative cell" RELATED [PomBase:mah] synonym: "rounded vegetative cell" EXACT [PomBase:mah] synonym: "spheroid cell during vegetative growth" EXACT [PomBase:mah] synonym: "spheroid vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001955 ! spheroid cell is_a: FYPO:0002196 ! abnormal vegetative cell shape intersection_of: PATO:0001865 ! spheroid intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000022 name: shmoo with long tip def: "A cell morphology phenotype in which a cell forms a mating projection with a longer tip than normal." [PomBase:mah] synonym: "cell morphology, shmoos with long tips" EXACT [PomBase:mah] synonym: "conjugation tube with long tip" EXACT [PomBase:mah] synonym: "mating projection with long tip" EXACT [PomBase:mah] is_a: FYPO:0000357 ! abnormal shmoo morphology is_a: PATO:0000573 ! increased length intersection_of: PATO:0000573 ! increased length intersection_of: inheres_in GO:0043332 ! mating projection tip relationship: inheres_in GO:0043332 ! mating projection tip created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000023 name: small cell def: "A cell morphology phenotype in which a cell has an abnormally low volume." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. Note that this term is not classified as a type of abnormal cell shape, small cells, have the same proportions as a subset of wild-type cells, and simply do not grow to the full length seen in wild type. Elongated cells, in contrast, have proportions (length:width ratio) that are never observed in wild-type cells, and so are classified under both abnormal cell shape and abnormal cell size. subset: qc_do_not_manually_annotate synonym: "cell size: decreased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001127 ! abnormal cell size is_a: PATO:0000596 ! decreased volume intersection_of: PATO:0000596 ! decreased volume intersection_of: inheres_in CL:0000000 ! cell relationship: inheres_in CL:0000000 ! cell created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000024 name: stubby cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which the cell diameter is larger than normal and the cell length is shorter than normal." [PomBase:mah] synonym: "cell morphology, stubby cells" EXACT [PomBase:mah] synonym: "stubby cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "stubby cell during vegetative growth" EXACT [PomBase:mah] synonym: "watermelon-shaped cell" EXACT [PomBase:mah] is_a: FYPO:0002196 ! abnormal vegetative cell shape is_a: PATO:0001643 ! stubby intersection_of: PATO:0001643 ! stubby intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000025 name: swollen cell def: "A cell morphology phenotype in which a cell has a larger volume than normal. In a swollen cell, both length and diameter are greater than normal, although the cell is only considered elongated if the length:width ratio is also greater than normal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "cell morphology, swollen cells" EXACT [PomBase:mah] synonym: "enlarged cell" RELATED [PomBase:mah] synonym: "increased cell size" RELATED [PomBase:vw] synonym: "increased cell volume" EXACT [PomBase:mah] synonym: "large cell" RELATED [PomBase:vw] is_a: FYPO:0001127 ! abnormal cell size is_a: PATO:0000595 ! increased volume intersection_of: PATO:0000595 ! increased volume intersection_of: inheres_in CL:0000000 ! cell relationship: inheres_in CL:0000000 ! cell created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000026 name: abnormal cell polarity def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the establishment or maintenance of cell polarity is abnormal." [PomBase:mah] synonym: "abnormal cell polarity during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal cell polarity during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal establishment or maintenance of cell polarity" EXACT [PomBase:mah] synonym: "cell polarity defects" EXACT [PomBase:mah] is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0007163 ! establishment or maintenance of cell polarity intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0007163 ! establishment or maintenance of cell polarity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000027 name: abnormal cell wall during vegetative growth def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the cell wall is abnormal." [PomBase:mah] synonym: "abnormal cell wall during mitotic cell cycle" RELATED [PomBase:mah] synonym: "cell wall defects during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0009277 ! fungal-type cell wall intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0009277 ! fungal-type cell wall relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000029 name: abnormal chromosome segregation alt_id: FYPO:0000226 def: "A cellular process phenotype in which chromosome segregation is abnormal. Chromosome segregation begins with the alignment of chromosomes at the metaphase plate, includes sister chromatid separation, and ends when chromosomes have completed movement to the spindle poles." [GO:0007059, PomBase:mah] synonym: "centromere function defective" RELATED [PomBase:mah] synonym: "chromosome segregation defects" EXACT [PomBase:mah] synonym: "chromosome segregation: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000628 ! abnormal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0007059 ! chromosome segregation intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0007059 ! chromosome segregation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000030 name: abnormal mitotic chromosome congression def: "A cellular process phenotype in which chromosome congression is abnormal during mitosis. Chromosome congression is the alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle." [GO:0051310, PomBase:mah] synonym: "abnormal chromosome congression at mitotic metaphase plate" EXACT [PomBase:mah] synonym: "abnormal chromosome congression during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal mitotic metaphase plate congression" EXACT [GO:0007080] synonym: "chromosome segregation defects, chromosome congression" EXACT [PomBase:mah] is_a: FYPO:0001337 ! localization phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0002737 ! abnormal mitotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0007080 ! mitotic metaphase plate congression intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0007080 ! mitotic metaphase plate congression relationship: part_of FYPO:0000141 ! abnormal mitotic sister chromatid segregation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000031 name: abnormal conjugation def: "A cellular process phenotype in which conjugation is abnormal. Conjugation, also known as mating, is a process that results in the union of cellular and genetic information from cells of compatible mating types." [GO:0000747, PomBase:mah] synonym: "abnormal conjugation with cellular fusion" EXACT [PomBase:mah] synonym: "abnormal zygote formation" RELATED [PomBase:mah] synonym: "conjugation defects" EXACT [PomBase:mah] is_a: FYPO:0000301 ! mating phenotype is_a: FYPO:0001985 ! abnormal phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0000747 ! conjugation with cellular fusion intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0000747 ! conjugation with cellular fusion relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000032 name: abnormal cytokinesis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which cytokinesis is abnormal. Cytokinesis is part of the cell cycle and results in the division of the cytoplasm of a cell and its separation into two daughter cells." [GO:0000281, PomBase:mah] synonym: "abnormal cell cycle cytokinesis" EXACT [PomBase:mah] synonym: "abnormal cytokinesis during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal mitotic cytokinesis" EXACT [PomBase:mah] synonym: "cytokinesis defects" EXACT [PomBase:mah] synonym: "cytokinesis: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000186 ! abnormal cell division is_a: FYPO:0002737 ! abnormal mitotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000281 ! mitotic cytokinesis intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000281 ! mitotic cytokinesis relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000033 name: abnormal actomyosin contractile ring localization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which actomyosin contractile ring localization is abnormal. Actomyosin contractile ring localization is the part of cytokinesis in which the actomyosin contractile ring is assembled and/or maintained in a specific location." [GO:1902405, PomBase:mah] comment: Note that the location of the contractile ring is determined by the location of the cell division site, so an abnormality in cell division site determination can be inferred from this phenotype. Consider also annotating to 'abnormal septum site selection' (FYPO:0002154) because if the contractile ring forms in an abnormal location, the septum will also do so. The positions of both the contractile ring and the septum are determined by the processes that select the site of cell division. synonym: "abnormal actomyosin contractile ring localisation" EXACT [PomBase:mah] synonym: "abnormal actomyosin contractile ring localization during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal actomyosin contractile ring localization involved in mitotic cytokinesis" EXACT [GO:1902405, PomBase:mah] synonym: "abnormal cytokinetic contractile ring localization" EXACT [PomBase:vw] synonym: "abnormal mitotic contractile ring localization" EXACT [PomBase:vw] synonym: "cytokinesis defects, misplaced contractile ring" EXACT [PomBase:mah] is_a: FYPO:0000032 ! abnormal cytokinesis is_a: FYPO:0001337 ! localization phenotype during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1902405 ! mitotic actomyosin contractile ring localization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1902405 ! mitotic actomyosin contractile ring localization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000034 name: abnormal endocytosis during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which endocytosis is abnormal. Endocytosis is a vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. A phenotype may affect endocytosis of all cargoes, or of specific cargo such as a particular protein." [GO:0006897, PomBase:mah] synonym: "abnormal actin-mediated endocytosis during vegetative growth" EXACT [PomBase:vw] synonym: "abnormal endocytosis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein internalization during vegetative growth" NARROW [PomBase:mah] synonym: "endocytosis defects during vegetative growth" EXACT [PomBase:mah] synonym: "endocytosis: abnormal during vegetative growth" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000213 ! abnormal vesicle-mediated transport during vegetative growth is_a: FYPO:0003886 ! abnormal endocytosis intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006897 ! endocytosis intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006897 ! endocytosis relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000035 name: growth auxotrophic for arginine def: "Auxotrophy in which a cell is unable to synthesize arginine, and therefore requires arginine in the medium for vegetative cell growth." [PomBase:mah] synonym: "arginine auxotrophy" EXACT [PomBase:mah] synonym: "growth auxotrophic for arginine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "growth auxotrophic for arginine during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000128 ! auxotrophy is_a: PATO:0000422 ! auxotrophic intersection_of: PATO:0000422 ! auxotrophic intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:16467 ! L-arginine relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:16467 ! L-arginine created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000036 name: growth auxotrophic for asparagine def: "Auxotrophy in which a cell is unable to synthesize asparagine, and therefore requires asparagine in the medium for vegetative cell growth." [PomBase:mah] synonym: "asparagine auxotrophy" EXACT [PomBase:mah] synonym: "growth auxotrophic for asparagine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "growth auxotrophic for asparagine during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000128 ! auxotrophy is_a: PATO:0000422 ! auxotrophic intersection_of: PATO:0000422 ! auxotrophic intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:17196 ! L-asparagine relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:17196 ! L-asparagine created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000037 name: growth auxotrophic for cysteine def: "Auxotrophy in which a cell is unable to synthesize cysteine, and therefore requires cysteine in the medium for vegetative cell growth." [PomBase:mah] synonym: "cysteine auxotrophy" EXACT [PomBase:mah] synonym: "growth auxotrophic for cysteine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "growth auxotrophic for cysteine during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003355 ! growth auxotrophic for sulfur-containing amino acid intersection_of: PATO:0000422 ! auxotrophic intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:17561 ! L-cysteine relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:17561 ! L-cysteine created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000038 name: growth auxotrophic for ethanolamine def: "Auxotrophy in which a cell is unable to synthesize ethanolamine, and therefore requires ethanolamine in the medium for vegetative cell growth." [PomBase:mah] synonym: "ethanolamine auxotrophy" EXACT [PomBase:mah] synonym: "growth auxotrophic for ethanolamine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "growth auxotrophic for ethanolamine during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000128 ! auxotrophy is_a: PATO:0000422 ! auxotrophic intersection_of: PATO:0000422 ! auxotrophic intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:16000 ! ethanolamine relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:16000 ! ethanolamine created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000039 name: growth auxotrophic for lysine def: "Auxotrophy in which a cell is unable to synthesize lysine, and therefore requires lysine in the medium for vegetative cell growth." [PomBase:mah] synonym: "growth auxotrophic for lysine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "growth auxotrophic for lysine during vegetative growth" EXACT [PomBase:mah] synonym: "lysine auxotrophy" EXACT [PomBase:mah] is_a: FYPO:0000128 ! auxotrophy is_a: PATO:0000422 ! auxotrophic intersection_of: PATO:0000422 ! auxotrophic intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:18019 ! L-lysine relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:18019 ! L-lysine created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000040 name: growth auxotrophic for methionine def: "Auxotrophy in which a cell is unable to synthesize methionine, and therefore requires methionine in the medium for vegetative cell growth." [PomBase:mah] synonym: "growth auxotrophic for methionine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "growth auxotrophic for methionine during vegetative growth" EXACT [PomBase:mah] synonym: "methionine auxotrophy" EXACT [PomBase:mah] is_a: FYPO:0003355 ! growth auxotrophic for sulfur-containing amino acid intersection_of: PATO:0000422 ! auxotrophic intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:16643 ! L-methionine relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:16643 ! L-methionine created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000041 name: growth auxotrophic for phenylalanine def: "Auxotrophy in which a cell is unable to synthesize phenylalanine, and therefore requires phenylalanine in the medium for vegetative cell growth." [PomBase:mah] synonym: "growth auxotrophic for phenylalanine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "growth auxotrophic for phenylalanine during vegetative growth" EXACT [PomBase:mah] synonym: "phenylalanine auxotrophy" EXACT [PomBase:mah] is_a: FYPO:0000128 ! auxotrophy is_a: PATO:0000422 ! auxotrophic intersection_of: PATO:0000422 ! auxotrophic intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:17295 ! L-phenylalanine relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:17295 ! L-phenylalanine created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000042 name: growth auxotrophic for sulfite def: "Auxotrophy in which a cell is unable to synthesize sulfite, and therefore requires sulfite in the medium for vegetative cell growth." [PomBase:mah] synonym: "growth auxotrophic for sulfite during mitotic cell cycle" RELATED [PomBase:mah] synonym: "growth auxotrophic for sulfite during vegetative growth" EXACT [PomBase:mah] synonym: "growth auxotrophic for sulphite" EXACT [PomBase:mah] synonym: "sulfite auxotrophy" EXACT [PomBase:mah] is_a: FYPO:0000128 ! auxotrophy intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: qualifier PATO:0000422 ! auxotrophic intersection_of: towards CHEBI:17359 ! sulfite relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: qualifier PATO:0000422 ! auxotrophic relationship: towards CHEBI:17359 ! sulfite created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000043 name: abnormal glucan synthesis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which glucan biosynthesis is abnormal." [PomBase:mah] synonym: "abnormal glucan biosynthetic process" EXACT [PomBase:mah] synonym: "abnormal glucan synthesis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal glucan synthesis during vegetative growth" EXACT [PomBase:mah] synonym: "glucan synthesis defective" EXACT [PomBase:mah] is_a: FYPO:0000860 ! abnormal metabolic process is_a: FYPO:0001348 ! cellular metabolism phenotype during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0009250 ! glucan biosynthetic process intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0009250 ! glucan biosynthetic process relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000044 name: abnormal negative regulation of transcription by glucose alt_id: FYPO:0000210 def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which negative regulation of transcription by glucose (glucose repression) is abnormal. Specific genes that are normally not transcribed in the presence of glucose are transcribed in the mutant." [GO:0045014, PomBase:mah] synonym: "abnormal glucose repression" EXACT [GO:0045014, PomBase:mah] synonym: "abnormal glucose repression during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal negative regulation of transcription by glucose during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal negative regulation of transcription by glucose during vegetative growth" EXACT [PomBase:mah] synonym: "glucose repression defects" EXACT [PomBase:mah] is_a: FYPO:0000624 ! abnormal negative regulation of transcription during vegetative growth is_a: FYPO:0001342 ! cellular response phenotype during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0045014 ! negative regulation of transcription by glucose intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0045014 ! negative regulation of transcription by glucose relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000045 name: abnormal cell population growth def: "A cell population phenotype in which a population of cells grow abnormally." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "growth defect" RELATED [PomBase:mah] is_a: FYPO:0000139 ! cell population growth phenotype is_a: FYPO:0000300 ! biological process phenotype created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000046 name: decreased cell population growth alt_id: FYPO:0000222 def: "A cell population phenotype in which cell population growth is decreased relative to normal. Decreased growth may reflect a reduced growth rate (i.e. slower growth), growth that occurs to a lesser extent than normal, or both." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "aerobic growth defects" RELATED [PomBase:mah] synonym: "decreased aerobic cell population growth" NARROW [PomBase:mah] synonym: "decreased growth" BROAD [PomBase:mah] synonym: "reduced aerobic cell population growth" NARROW [PomBase:mah] synonym: "reduced cell population growth" EXACT [PomBase:mah] synonym: "slow aerobic cell population growth" NARROW [PomBase:mah] is_a: FYPO:0000045 ! abnormal cell population growth is_a: FYPO:0002058 ! viable cell population created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000047 name: normal cell population growth def: "A cell population phenotype in which a population of cells grow normally." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "growth normal" BROAD [PomBase:mah] is_a: FYPO:0000139 ! cell population growth phenotype is_a: FYPO:0002058 ! viable cell population created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000048 name: invasive growth abolished alt_id: FYPO:0000465 def: "A cellular process phenotype in which invasive growth does not occur." [PomBase:mah] comment: This term was made obsolete because it is not required to describe fission yeast. synonym: "absent invasive growth" EXACT [PomBase:mah] synonym: "invasive growth abolished during vegetative growth" EXACT [PomBase:mah] synonym: "invasive growth: absent" EXACT [SGD:phenotype_annotation] is_obsolete: true consider: FYPO:0000551 created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000049 name: inviable cell def: "A viability phenotype in which a cell is unable to survive under conditions in which wild type cells survive." [PomBase:mah] comment: Viability is usually determined under standard laboratory conditions, i.e. a cell is generally considered inviable if it cannot grow in rich medium under normal conditions such as temperature, pressure, oxygen level, pH, etc. Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "essential" RELATED [PomBase:mah] synonym: "lethal" EXACT [PomBase:mah] is_a: FYPO:0000004 ! cell viability is_a: PATO:0000718 ! lethal (sensu genetics) intersection_of: PATO:0000718 ! lethal (sensu genetics) intersection_of: inheres_in CL:0000000 ! cell relationship: inheres_in CL:0000000 ! cell created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000050 name: abnormal kinetochore morphology def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of the kinetochore is abnormal." [PomBase:mah] comment: Note that an abnormal kinetochore organization process may, but does not necessarily, result in abnormal kinetochore structure. synonym: "abnormal kinetochore morphology during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal kinetochore morphology during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal kinetochore structure" NARROW [PomBase:mah] synonym: "kinetochore defects" EXACT [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000776 ! kinetochore intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000776 ! kinetochore relationship: output_of FYPO:0000807 ! abnormal kinetochore organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000051 name: abnormal meiosis alt_id: FYPO:0000738 def: "A cellular process phenotype in which meiosis is abnormal. Meiosis refers specifically to the nuclear division phases of a meiotic cell cycle." [PomBase:mah] synonym: "abnormal meiotic nuclear division" EXACT [GO:0007126] synonym: "meiosis defects" EXACT [PomBase:mah] synonym: "meiosis: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000335 ! abnormal cellular component organization is_a: FYPO:0002739 ! abnormal meiotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0007126 ! meiotic nuclear division intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0007126 ! meiotic nuclear division relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000052 name: abnormal meiotic cell cycle def: "A cellular process phenotype in which a cell does not proceed normally through a meiotic cell cycle." [PomBase:mah] synonym: "meiotic cell cycle defects" EXACT [PomBase:mah] is_a: FYPO:0000011 ! abnormal cell cycle intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0051321 ! meiotic cell cycle intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0051321 ! meiotic cell cycle relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000054 name: abnormal microtubule cytoskeleton organization alt_id: FYPO:0000053 def: "A phenotype that affects the organization of the microtubule cytoskeleton. Microtubule cytoskeleton organization is a cellular process that results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GO:0000226, PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. Note that an abnormal microtubule cytoskeleton organization process may, but does not necessarily, result in a physically abnormal microtubule cytoskeleton. subset: qc_do_not_manually_annotate synonym: "abnormal microtubule cytoskeleton organisation" EXACT [PomBase:mah] synonym: "abnormal microtubule organisation" RELATED [PomBase:mah] synonym: "abnormal microtubule organization" RELATED [PomBase:mah] synonym: "microtubule cytoskeleton defects" EXACT [PomBase:mah] synonym: "microtubule organization defects" RELATED [PomBase:mah] is_a: FYPO:0000297 ! microtubule cytoskeleton organization phenotype is_a: FYPO:0000802 ! abnormal cytoskeleton organization intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0000226 ! microtubule cytoskeleton organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0000226 ! microtubule cytoskeleton organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000055 name: long microtubules def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells form microtubules that are longer than normal." [PomBase:mah] synonym: "elongated microtubules" EXACT [PomBase:mah] synonym: "long microtubules during mitotic cell cycle" RELATED [PomBase:mah] synonym: "long microtubules during vegetative growth" EXACT [PomBase:mah] synonym: "microtubule organization defects, long microtubules" EXACT [PomBase:mah] is_a: FYPO:0001418 ! abnormal microtubule cytoskeleton morphology during vegetative growth is_a: PATO:0000573 ! increased length intersection_of: PATO:0000573 ! increased length intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005874 ! microtubule relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005874 ! microtubule created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000056 name: mitochondria fused def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which mitochondria have fused into fewer and larger structures than normal." [PomBase:mah] synonym: "fused mitochondria" EXACT [PomBase:mah] synonym: "mitochondria fused during mitotic cell cycle" RELATED [PomBase:mah] synonym: "mitochondria fused during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000359 ! abnormal mitochondrial morphology is_a: PATO:0000642 ! fused with intersection_of: PATO:0000642 ! fused with intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005739 ! mitochondrion intersection_of: towards GO:0005739 ! mitochondrion relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005739 ! mitochondrion relationship: towards GO:0005739 ! mitochondrion created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000057 name: mitochondrial nucleoid enlarged def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the mitochondrial nucleoid is larger than normal." [PomBase:mah] synonym: "mitochondrial nucleoid enlarged during mitotic cell cycle" RELATED [PomBase:mah] synonym: "mitochondrial nucleoid enlarged during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: PATO:0000586 ! increased size intersection_of: PATO:0000586 ! increased size intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0042645 ! mitochondrial nucleoid relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0042645 ! mitochondrial nucleoid created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000058 name: mitochondrial nucleoid decreased number def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which a cell contains fewer mitochondrial nucleoids than normal." [PomBase:mah] synonym: "mitochondrial nucleoid decreased number during mitotic cell cycle" RELATED [PomBase:mah] synonym: "mitochondrial nucleoid decreased number during vegetative growth" EXACT [PomBase:mah] synonym: "mitochondrial nucleoid reduced number" EXACT [PomBase:mah] synonym: "mitochondrial nucleoids present in decreased number" RELATED [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: PATO:0002001 ! has fewer parts of type intersection_of: PATO:0002001 ! has fewer parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0042645 ! mitochondrial nucleoid relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0042645 ! mitochondrial nucleoid created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000059 name: abnormal mitotic cell cycle def: "A cellular process phenotype in which a cell does not proceed normally through a mitotic cell cycle." [PomBase:mah] synonym: "mitotic cell cycle defects" EXACT [PomBase:mah] synonym: "mitotic cell cycle: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000011 ! abnormal cell cycle intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0000278 ! mitotic cell cycle intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0000278 ! mitotic cell cycle relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000060 name: mononucleate vegetative cell def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which a cell contains a single nucleus." [PomBase:mah] synonym: "mononucleate during vegetative growth" EXACT [PomBase:mah] synonym: "mononucleate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001321 ! cellular physical quality phenotype during vegetative growth is_a: FYPO:0002731 ! mononucleate intersection_of: PATO:0001407 ! mononucleate intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000061 name: multinucleate vegetative cell def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which a cell contains more than one nucleus." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "multinucleate cells during vegetative growth" EXACT [PomBase:al] synonym: "multinucleate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "multiple nuclei during vegetative growth" EXACT [PomBase:al] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: FYPO:0003341 ! multinucleate intersection_of: PATO:0001908 ! multinucleate intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000062 name: abnormal nuclear morphology during vegetative growth alt_id: FYPO:0000259 def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of the nucleus is abnormal." [PomBase:mah] comment: Note that an abnormal nucleus organization process may, but does not necessarily, result in abnormal nuclear morphology. synonym: "abnormal nuclear morphology during mitotic cell cycle" RELATED [PomBase:mah] synonym: "nuclear morphology defects during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: FYPO:0002256 ! abnormal nuclear morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005634 ! nucleus intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005634 ! nucleus relationship: output_of FYPO:0000810 ! abnormal nucleus organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000063 name: abnormal DNA recombination def: "A cellular process phenotype in which DNA recombination is abnormal. DNA recombination is a process that results in reassortment of genes, producing gene combinations different from those that were present in the parents." [GO:0006310, PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "abnormal recombination" EXACT [PomBase:vw] synonym: "recombination defects" EXACT [PomBase:mah] is_a: FYPO:0000293 ! DNA metabolism phenotype is_a: FYPO:0000860 ! abnormal metabolic process intersection_of: inheres_in_part_of GO:0006310 ! DNA recombination intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0006310 ! DNA recombination relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000064 name: resistance to 2-deoxyglucose def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of 2-deoxyglucose than normal." [PomBase:mah] synonym: "resistance to 2-deoxyglucose during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to 2-deoxyglucose during vegetative growth" EXACT [PomBase:mah] synonym: "resistance to 2-DOG" EXACT [PomBase:mah] synonym: "resistant to 2-deoxy-D-glucose" EXACT [CHEBI:15866, PomBase:mah] synonym: "resistant to 2-DOG" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:15866 ! 2-deoxy-D-glucose relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:15866 ! 2-deoxy-D-glucose created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000065 name: resistance to 5-azacytidine def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of 5-azacytidine than normal." [PomBase:mah] synonym: "resistance to 5-azacytidine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to 5-azacytidine during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to 5-azacytidine" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:2038 ! 5-azacytidine relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:2038 ! 5-azacytidine created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000066 name: resistance to L-azetidine-2-carboxylic acid def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of L-azetidine-2-carboxylic acid than normal." [PomBase:mah] synonym: "resistance to (S)-azetidine-2-carboxylic acid" EXACT [CHEBI:6198, PomBase:mah] synonym: "resistance to AZC" BROAD [PomBase:mah] synonym: "resistance to L-azetidine-2-carboxylic acid during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to L-azetidine-2-carboxylic acid during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to L-azetidine-2-carboxylic acid" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:6198 ! (S)-azetidine-2-carboxylic acid relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:6198 ! (S)-azetidine-2-carboxylic acid created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000067 name: resistance to brefeldin A def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of brefeldin A than normal." [PomBase:mah] synonym: "resistance to BFA" EXACT [PomBase:mah] synonym: "resistance to brefeldin A during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to brefeldin A during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to Brefeldin A" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:48080 ! brefeldin A relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:48080 ! brefeldin A created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000068 name: resistance to K-252a def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of K-252a than normal." [PomBase:mah] synonym: "resistance to K-252a during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to K-252a during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to K-252a" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:43616 ! K-252a relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:43616 ! K-252a created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000069 name: resistance to thiabendazole def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of thiabendazole than normal." [PomBase:mah] synonym: "resistance to TBZ" EXACT [PomBase:mah] synonym: "resistance to thiabendazole during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to thiabendazole during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to TBZ" EXACT [CHEBI:45979, PomBase:mah] synonym: "resistant to thiabendazole" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:45979 ! thiabendazole relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:45979 ! thiabendazole created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000070 name: resistance to amphotericin B def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of amphotericin B than normal." [PomBase:mah] synonym: "resistance to amphotericin B during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to amphotericin B during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to amphotericin" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:2682 ! amphotericin B relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:2682 ! amphotericin B created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000071 name: resistance to aureobasidin A def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of aureobasidin A than normal." [PomBase:mah] synonym: "resistance to AbA" EXACT [PMID:9472078] synonym: "resistance to aureobasidin A during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to aureobasidin A during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to aureobasidin A" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:61739 ! aureobasidin A relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:61739 ! aureobasidin A created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000072 name: resistance to benomyl def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of benomyl than normal." [PomBase:mah] synonym: "resistance to benomyl during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to benomyl during vegetative growth" EXACT [PomBase:mah] synonym: "resistance to methyl benzimidazole-2-yl-carbamate" EXACT [PMID:6887244] synonym: "resistant to benomyl" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:3015 ! benomyl relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:3015 ! benomyl created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000073 name: resistance to caffeine def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of caffeine than normal." [PomBase:mah] synonym: "resistance to caffeine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to caffeine during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to caffeine" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards http://purl.obolibrary.org/obo/CHEBI_ relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards http://purl.obolibrary.org/obo/CHEBI_ created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000074 name: resistance to drug def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of a drug than normal." [PomBase:mah] comment: This term was made obsolete because 'drug' is not defined clearly. Search for a specific term for resistance to the substance used in the assay. synonym: "drug resistance" EXACT [PomBase:mah] synonym: "drug resistant" EXACT [PomBase:mah] synonym: "resistance to drug during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to drugs" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000075 name: resistance to lovastatin def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of lovastatin than normal." [PomBase:mah] synonym: "resistance to lovastatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to lovastatin during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to lovastatin" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:40303 ! lovastatin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:40303 ! lovastatin created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000076 name: resistance to nystatin def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of nystatin than normal." [PomBase:mah] synonym: "resistance to nystatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to nystatin during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to nystatin" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:7660 ! nystatin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:7660 ! nystatin created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000077 name: resistance to rapamycin def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of rapamycin than normal." [PomBase:mah] synonym: "resistance to rapamycin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to rapamycin during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to rapamycin" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:9168 ! sirolimus relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:9168 ! sirolimus created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000078 name: abnormal cellular respiration def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which cellular respiration is abnormal." [PomBase:mah] synonym: "abnormal cellular respiration during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal cellular respiration during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal respiration" BROAD [PomBase:mah] synonym: "abnormal respiratory metabolism" EXACT [PomBase:mah] synonym: "respiratory metabolism: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001363 ! abnormal metabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0045333 ! cellular respiration intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0045333 ! cellular respiration relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000079 name: sensitive to caspofungin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to caspofungin. Cells stop growing (and may die) at a concentration of caspofungin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to caspofungin" EXACT [PomBase:mah] synonym: "sensitive to caspofungin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to caspofungin during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to glucan synthase inhibitor" BROAD [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:474180 ! caspofungin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:474180 ! caspofungin created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000080 name: decreased cell population growth at low temperature alt_id: FYPO:0002175 def: "A vegetative cell population growth phenotype in which cell growth is decreased relative to normal at a low temperature." [PomBase:mah] comment: Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. For fission yeast, low temperature usually corresponds to below 25 degrees Celsius. synonym: "cold sensitive" RELATED [PomBase:mah] synonym: "cold sensitivity: increased" RELATED [SGD:phenotype_annotation] synonym: "decreased growth at low temperature" BROAD [PomBase:mah] synonym: "decreased vegetative cell population growth at low temperature" EXACT [PomBase:mah] synonym: "growth defect, slow growth at low temperatures" RELATED [PomBase:mah] synonym: "hypersensitive to cold" RELATED [PomBase:mah] synonym: "reduced growth at low temperature" RELATED [PomBase:mah] synonym: "sensitive to cold" RELATED [PomBase:mah] synonym: "sensitive to cold during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to cold during vegetative growth" EXACT [PomBase:mah] synonym: "slow growth at low temperature" RELATED [PomBase:mah] is_a: FYPO:0001355 ! decreased vegetative cell population growth intersection_of: FYPO:0000046 ! decreased cell population growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0001306 ! decreased temperature relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0001306 ! decreased temperature created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000081 name: sensitive to high osmolarity def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to conditions of high osmolarity." [PomBase:mah] synonym: "hyperosmotic stress resistance: decreased" EXACT [SGD:phenotype_annotation] synonym: "hypersensitive to high osmolarity" EXACT [PomBase:mah] synonym: "sensitive to high osmolarity during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to high osmolarity during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to hyperosmotic conditions" EXACT [PomBase:mah] is_a: FYPO:0000270 ! sensitive to osmotic stress created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000082 name: decreased cell population growth at high temperature alt_id: FYPO:0000247 def: "A cell population phenotype in which the growth of a population of cells is decreased relative to normal in the vegetative growth phase of the life cycle at high temperatures." [PomBase:mah] comment: For fission yeast, high temperature usually corresponds to above 32 degrees Celsius. Use this term if you have assayed growth of cells exposed to heat in culture. If you have assayed the response to heat at the subcellular or molecular level, consider annotating to 'abnormal cellular response to heat' (FYPO:0000212). synonym: "decreased cell population growth at high temperature during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased growth at high temperature" BROAD [PomBase:mah] synonym: "decreased vegetative cell population growth at high temperature" EXACT [PomBase:mah] synonym: "growth defect, slow growth at high temperatures" NARROW [PomBase:mah] synonym: "heat sensitive" RELATED [PomBase:mah] synonym: "heat sensitivity: increased" RELATED [SGD:phenotype_annotation] synonym: "hypersensitive to high temperature" RELATED [PomBase:mah] synonym: "reduced growth at high temperature" EXACT [PomBase:mah] synonym: "sensitive to heat" RELATED [PomBase:mah] synonym: "sensitive to high temperature" RELATED [PomBase:mah] synonym: "sensitive to high temperature during vegetative growth" RELATED [PomBase:mah] synonym: "slow growth at high temperature" NARROW [PomBase:mah] synonym: "temperature sensitive" RELATED [PomBase:mah] is_a: FYPO:0001355 ! decreased vegetative cell population growth created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000083 name: sensitive to enfumafungin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to enfumafungin. Cells stop growing (and may die) at a concentration of enfumafungin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to enfumafungin" EXACT [PomBase:mah] synonym: "sensitive to enfumafungin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to enfumafungin during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to glucan synthase inhibitor" BROAD [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:61749 ! enfumafungin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:61749 ! enfumafungin created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000084 name: sensitive to 6-azauracil def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to 6-azauracil. Cells stop growing (and may die) at a concentration of 6-azauracil that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to 6-azauracil" EXACT [PomBase:mah] synonym: "sensitive to 6-azauracil during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to 6-azauracil during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:53745 ! 6-azauracil relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:53745 ! 6-azauracil created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000085 name: sensitive to camptothecin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to camptothecin. Cells stop growing (and may die) at a concentration of camptothecin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to camptothecin" EXACT [PomBase:mah] synonym: "sensitive to camptothecin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to camptothecin during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to CPT" EXACT [CHEBI:27656, PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:27656 ! camptothecin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:27656 ! camptothecin created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000086 name: sensitive to tacrolimus def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to tacrolimus. Cells stop growing (and may die) at a concentration of tacrolimus that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to tacrolimus" EXACT [PomBase:mah] synonym: "sensitive to FK506" EXACT [CHEBI:61057, PomBase:mah] synonym: "sensitive to tacrolimus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to tacrolimus during vegetative growth" EXACT [smPomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:61057 ! tacrolimus hydrate relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:61057 ! tacrolimus hydrate created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000087 name: sensitive to hydrogen peroxide def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to hydrogen peroxide. Cells stop growing (and may die) at a concentration of hydrogen peroxide that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to hydrogen peroxide" EXACT [PomBase:mah] synonym: "sensitive to H2O2" EXACT [PomBase:mah] synonym: "sensitive to hydrogen peroxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:16240 ! hydrogen peroxide relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:16240 ! hydrogen peroxide created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000088 name: sensitive to hydroxyurea def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to hydroxyurea. Cells stop growing (and may die) at a concentration of hydroxyurea that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to hydroxyurea" EXACT [PomBase:mah] synonym: "sensitive to HU" EXACT [PomBase:mah] synonym: "sensitive to hydroxyurea during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to hydroxyurea during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:44423 ! hydroxyurea relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:44423 ! hydroxyurea created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000089 name: sensitive to methyl methanesulfonate def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to methyl methanesulfonate. Cells stop growing (and may die) at a concentration of methyl methanesulfonate that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to methyl methanesulfonate" EXACT [PomBase:mah] synonym: "sensitive to methyl methanesulfonate during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to methyl methanesulfonate during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to methyl methanesulphonate" EXACT [PomBase:mah] synonym: "sensitive to MMS" EXACT [CHEBI:25255, PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:25255 ! methyl methanesulfonate relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:25255 ! methyl methanesulfonate created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000090 name: sensitive to N-ethylmaleimide def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to N-ethylmaleimide. Cells stop growing (and may die) at a concentration of N-ethylmaleimide that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to N-ethylmaleimide" EXACT [PomBase:mah] synonym: "sensitive to N-ethylmaleimide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to N-ethylmaleimide during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to NEM" EXACT [CHEBI:44485, PomBase:al] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:44485 ! N-ethylmaleimide relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:44485 ! N-ethylmaleimide created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000091 name: sensitive to thiabendazole def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to thiabendazole. Cells stop growing (and may die) at a concentration of thiabendazole that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to thiabendazole" EXACT [PomBase:mah] synonym: "sensitive to TBZ" EXACT [CHEBI:45979, PomBase:mah] synonym: "sensitive to thiabendazole during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to thiabendazole during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:45979 ! thiabendazole relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:45979 ! thiabendazole created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000092 name: sensitive to amiodarone def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to amiodarone. Cells stop growing (and may die) at a concentration of amiodarone that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to amiodarone" EXACT [PomBase:mah] synonym: "sensitive to amiodarone during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to amiodarone during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:2663 ! amiodarone relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:2663 ! amiodarone created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000093 name: sensitive to arsenic def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to an arsenic-containing substance. Cells stop growing (and may die) at a concentration of arsenic that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to arsenic" EXACT [PomBase:mah] synonym: "sensitive to arsenic during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to arsenic during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to arsenic molecular entity" EXACT [CHEBI:22632] synonym: "sensitive to arsenic-containing substance" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:22632 ! arsenic molecular entity relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:22632 ! arsenic molecular entity created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000094 name: sensitive to benomyl def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to benomyl. Cells stop growing (and may die) at a concentration of benomyl that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to benomyl" EXACT [PomBase:mah] synonym: "sensitive to benomyl during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to benomyl during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to methyl benzimidazole-2-yl-carbamate" EXACT [PMID:6887244] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:3015 ! benomyl relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:3015 ! benomyl created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000095 name: sensitive to bleomycin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to bleomycin. Cells stop growing (and may die) at a concentration of bleomycin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to bleomycin" EXACT [PomBase:mah] synonym: "sensitive to bleomycin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to bleomycin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:22907 ! bleomycin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:22907 ! bleomycin created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000096 name: sensitive to cadmium def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to cadmium. Cells stop growing (and may die) at a concentration of cadmium ions that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to cadmium" EXACT [PomBase:mah] synonym: "sensitive to cadmium during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to cadmium during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to cadmium ions" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:22978 ! cadmium molecular entity relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:22978 ! cadmium molecular entity created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000097 name: sensitive to caffeine during vegetative growth def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to caffeine. Cells stop growing (and may die) at a concentration of caffeine that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to caffeine during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to caffeine during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:27732 ! caffeine relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:27732 ! caffeine created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000098 name: sensitive to calcium def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to calcium. Cells stop growing (and may die) at a concentration of calcium ions that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to calcium" EXACT [PomBase:mah] synonym: "sensitive to calcium chloride" NARROW [PomBase:mah] synonym: "sensitive to calcium during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to calcium during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to calcium ions" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:29108 ! calcium(2+) relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:29108 ! calcium(2+) created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000099 name: sensitive to canavanine def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to canavanine. Cells stop growing (and may die) at a concentration of canavanine that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to canavanine" EXACT [PomBase:mah] synonym: "sensitive to canavanine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to canavanine during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:609827 ! L-canavanine relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:609827 ! L-canavanine created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000100 name: sensitive to chloramphenicol def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to chloramphenicol. Cells stop growing (and may die) at a concentration of chloramphenicol that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to chloramphenicol" EXACT [PomBase:mah] synonym: "sensitive to chloramphenicol during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to chloramphenicol during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:17698 ! chloramphenicol relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:17698 ! chloramphenicol created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000101 name: sensitive to chlorpropham def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to chlorpropham. Cells stop growing (and may die) at a concentration of chlorpropham that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to chlorpropham" EXACT [PomBase:mah] synonym: "sensitive to chlorpropham during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to chlorpropham during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to isopropyl N-3-chlorophenyl carbamate" EXACT [PomBase:mah] synonym: "sensitive to spindle poison" BROAD [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:34630 ! chlorpropham relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:34630 ! chlorpropham created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000102 name: sensitive to cisplatin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to cisplatin. Cells stop growing (and may die) at a concentration of cisplatin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to cisplatin" EXACT [PomBase:mah] synonym: "sensitive to cis-DDP" EXACT [CHEBI:27899] synonym: "sensitive to cisplatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to cisplatin during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to DDP" BROAD [CHEBI:27899, PomBase:al] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:27899 ! cisplatin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:27899 ! cisplatin created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000103 name: sensitive to copper def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to copper ions. Cells stop growing (and may die) at a concentration of copper ions that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to copper" EXACT [PomBase:mah] synonym: "sensitive to copper during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to copper during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to copper ions" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:23378 ! copper cation relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:23378 ! copper cation created_by: midori creation_date: 2011-03-29T05:53:56Z [Term] id: FYPO:0000104 name: sensitive to cycloheximide def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to cycloheximide. Cells stop growing (and may die) at a concentration of cycloheximide that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to cycloheximide" EXACT [PomBase:mah] synonym: "sensitive to cycloheximide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to cycloheximide during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:27641 ! cycloheximide relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:27641 ! cycloheximide created_by: midori creation_date: 2011-03-29T05:54:40Z [Term] id: FYPO:0000105 name: sensitive to cyclosporin A def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to cyclosporin A. Cells stop growing (and may die) at a concentration of cyclosporin A that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to cyclosporin A" EXACT [PomBase:mah] synonym: "sensitive to cyclosporin A during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to cyclosporin A during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to cyclosporine" EXACT [CHEBI:4031, PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:4031 ! cyclosporin A relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:4031 ! cyclosporin A created_by: midori creation_date: 2011-03-29T05:54:40Z [Term] id: FYPO:0000106 name: sensitive to hygromycin B def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to hygromycin B. Cells stop growing (and may die) at a concentration of hygromycin B that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to hygromycin B" EXACT [PomBase:mah] synonym: "sensitive to hygromycin B during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to hygromycin B during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:16976 ! hygromycin B relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:16976 ! hygromycin B created_by: midori creation_date: 2011-03-29T05:54:40Z [Term] id: FYPO:0000107 name: sensitive to latrunculin A def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to latrunculin A. Cells stop growing (and may die) at a concentration of latrunculin A that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to latrunculin A" EXACT [PomBase:mah] synonym: "sensitive to LAT-A" EXACT [PomBase:vw] synonym: "sensitive to latrunculin A during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to latrunculin A during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:69136 ! latrunculin A relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:69136 ! latrunculin A created_by: midori creation_date: 2011-03-29T05:54:40Z [Term] id: FYPO:0000108 name: sensitive to menadione def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to menadione. Cells stop growing (and may die) at a concentration of menadione that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to menadione" EXACT [PomBase:mah] synonym: "sensitive to menadione during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to menadione during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to vitamin K3" RELATED [PomBase:al] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:28869 ! menadione relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:28869 ! menadione created_by: midori creation_date: 2011-03-29T05:54:40Z [Term] id: FYPO:0000109 name: sensitive to papulacandin B def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to papulacandin B. Cells stop growing (and may die) at a concentration of papulacandin B that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to papulacandin B" EXACT [PomBase:mah] synonym: "sensitive to papulacandin B during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to papulacandin B during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:569624 ! papulacandin B relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:569624 ! papulacandin B created_by: midori creation_date: 2011-03-29T05:54:40Z [Term] id: FYPO:0000110 name: sensitive to pravastatin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to pravastatin. Cells stop growing (and may die) at a concentration of pravastatin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to pravastatin" EXACT [PomBase:mah] synonym: "sensitive to pravastatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to pravastatin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:63618 ! pravastatin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:63618 ! pravastatin created_by: midori creation_date: 2011-03-29T05:54:40Z [Term] id: FYPO:0000111 name: sensitive to rapamycin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to rapamycin. Cells stop growing (and may die) at a concentration of rapamycin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to rapamycin" EXACT [PomBase:mah] synonym: "sensitive to rapamycin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to rapamycin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:9168 ! sirolimus relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:9168 ! sirolimus created_by: midori creation_date: 2011-03-29T05:54:40Z [Term] id: FYPO:0000112 name: sensitive to sorbitol def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to sorbitol. Cells stop growing (and may die) at a concentration of sorbitol that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to sorbitol" EXACT [PomBase:mah] synonym: "sensitive to glucitol" EXACT [CHEBI:30911, PomBase:mah] synonym: "sensitive to sorbitol during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to sorbitol during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth is_a: FYPO:0002811 ! sensitive to non-ionic osmotic stress intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:30911 ! glucitol relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:30911 ! glucitol created_by: midori creation_date: 2011-03-29T05:54:40Z [Term] id: FYPO:0000113 name: sensitive to staurosporine def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to staurosporine. Cells stop growing (and may die) at a concentration of staurosporine that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to staurosporine" EXACT [PomBase:mah] synonym: "sensitive to staurosporine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to staurosporine during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:15738 ! staurosporine relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:15738 ! staurosporine created_by: midori creation_date: 2011-03-29T05:54:40Z [Term] id: FYPO:0000114 name: cellular process phenotype def: "A phenotype that affects a cellular process." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast cellular process phenotype" EXACT [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype is_a: FYPO:0000300 ! biological process phenotype intersection_of: FYPO:0000001 ! phenotype intersection_of: inheres_in_part_of GO:0044763 ! single-organism cellular process relationship: inheres_in_part_of GO:0044763 ! single-organism cellular process created_by: midori creation_date: 2011-04-12T12:00:38Z [Term] id: FYPO:0000115 name: sensitive to valproic acid def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to valproic acid. Cells stop growing (and may die) at a concentration of valproic acid that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to valproic acid" EXACT [PomBase:mah] synonym: "sensitive to valproic acid during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to valproic acid during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:39867 ! valproic acid relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:39867 ! valproic acid created_by: midori creation_date: 2011-03-29T05:54:40Z [Term] id: FYPO:0000116 name: sensitive to zinc def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to zinc ions. Cells stop growing (and may die) at a concentration of zinc ions that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to zinc" EXACT [PomBase:mah] synonym: "sensitive to zinc during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to zinc during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to zinc ions" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:27365 ! zinc ion relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:27365 ! zinc ion created_by: midori creation_date: 2011-03-29T05:54:40Z [Term] id: FYPO:0000117 name: abnormal septation alt_id: FYPO:0000170 def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which septation is abnormal." [PomBase:mah] synonym: "abnormal barrier septum formation involved in mitotic cytokinesis" EXACT [PomBase:mah] synonym: "abnormal mitotic barrier septum assembly" EXACT [GO:0000917, PomBase:mah] synonym: "abnormal septation during vegetative growth" EXACT [PomBase:mah] synonym: "septation defects" EXACT [PomBase:mah] synonym: "septum formation: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000032 ! abnormal cytokinesis is_a: FYPO:0001354 ! abnormal cellular component assembly during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000917 ! barrier septum assembly intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000917 ! barrier septum assembly relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:54:40Z [Term] id: FYPO:0000118 name: multiseptate vegetative cell def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle characterized by the presence of more than one septum in a cell." [PomBase:mah] synonym: "multiseptate during mitotic cell cycle" RELATED [PomBase:mah] synonym: "multiseptate during vegetative growth" EXACT [PomBase:mah] synonym: "septation defects, multiple septa during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: FYPO:0002342 ! septated vegetative cell is_a: FYPO:0004295 ! multiseptate cell intersection_of: PATO:0002002 ! has extra parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards GO:0000935 ! barrier septum relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards GO:0000935 ! barrier septum created_by: midori creation_date: 2011-03-29T05:54:40Z [Term] id: FYPO:0000119 name: abnormal spindle assembly alt_id: FYPO:0000285 def: "A cellular process phenotype in which spindle assembly is abnormal. Spindle assembly is the aggregation, arrangement and bonding together of a set of components to form the spindle." [GO:0051225, PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate is_a: FYPO:0000054 ! abnormal microtubule cytoskeleton organization is_a: FYPO:0000336 ! abnormal cellular component assembly is_a: FYPO:0002734 ! abnormal cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0051225 ! spindle assembly intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0051225 ! spindle assembly relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:54:40Z [Term] id: FYPO:0000120 name: abnormal spindle alt_id: FYPO:0000367 def: "A physical cellular phenotype in which the presence, distribution, or morphology of the mitotic or meiotic spindle is abnormal." [PomBase:mah] synonym: "spindle defects" EXACT [PomBase:mah] is_a: FYPO:0000287 ! abnormal subcellular component intersection_of: PATO:0001241 ! physical object quality intersection_of: inheres_in GO:0005819 ! spindle intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0005819 ! spindle relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:54:40Z [Term] id: FYPO:0000121 name: abnormal sporulation def: "A cellular process phenotype in which ascospore formation is abnormal." [PomBase:mah] synonym: "abnormal ascospore formation" EXACT [PomBase:mah] synonym: "sporulation defects" EXACT [PomBase:mah] synonym: "sporulation: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000679 ! developmental process phenotype is_a: FYPO:0002739 ! abnormal meiotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0030437 ! ascospore formation intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0030437 ! ascospore formation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:54:40Z [Term] id: FYPO:0000122 name: abnormal telomere maintenance def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which telomere maintenance, i.e. any process that contributes to the maintenance of proper telomeric length and structure, is abnormal." [GO:0000723, PomBase:mah] synonym: "abnormal telomere maintenance during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal telomere maintenance during vegetative growth" EXACT [PomBase:mah] synonym: "telomere maintenance defects" EXACT [PomBase:mah] is_a: FYPO:0000641 ! abnormal chromosome organization is_a: FYPO:0001334 ! regulation phenotype during vegetative growth is_a: FYPO:0001346 ! DNA metabolism phenotype during vegetative growth is_a: FYPO:0001353 ! abnormal cellular component organization during vegetative growth is_a: FYPO:0001363 ! abnormal metabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000723 ! telomere maintenance intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000723 ! telomere maintenance relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:54:40Z [Term] id: FYPO:0000123 name: large vacuoles during vegetative growth def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which vacuoles are larger than normal." [PomBase:mah] synonym: "large vacuoles during mitotic cell cycle" RELATED [PomBase:mah] synonym: "vacuole organization defects, large vacuoles" EXACT [PomBase:mah] is_a: FYPO:0000368 ! abnormal vacuolar morphology during vegetative growth is_a: PATO:0000586 ! increased size intersection_of: PATO:0000586 ! increased size intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole created_by: midori creation_date: 2011-03-29T05:54:40Z [Term] id: FYPO:0000124 name: viable cell def: "A viability phenotype in which a cell is able to survive under the specified conditions." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate is_a: FYPO:0000004 ! cell viability is_a: PATO:0000719 ! viable intersection_of: PATO:0000719 ! viable intersection_of: inheres_in CL:0000000 ! cell relationship: inheres_in CL:0000000 ! cell created_by: midori creation_date: 2011-03-29T05:54:40Z [Term] id: FYPO:0000125 name: resistance to amiloride def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of amiloride than normal." [PomBase:mah] synonym: "resistance to amiloride during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to amiloride during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to amiloride" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:2639 ! amiloride relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:2639 ! amiloride created_by: midori creation_date: 2011-03-29T05:54:40Z [Term] id: FYPO:0000126 name: increased resistance to chemical during vegetative growth def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased resistance to a chemical stimulus. Resistance to a chemical is usually measured by determining the maximum concentration of the chemical at which a population of cells grow and divide." [PomBase:mah] synonym: "increased resistance to chemical during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to chemicals: increased during vegetative growth" EXACT [PomBase:mah, SGD:phenotype_annotation] synonym: "resistant to chemical during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001358 ! vegetative cell population growth phenotype is_a: FYPO:0002682 ! increased resistance to chemical is_a: PATO:0001552 ! decreased sensitivity of a process intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:24431 ! chemical entity relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:24431 ! chemical entity created_by: midori creation_date: 2011-03-29T05:54:40Z [Term] id: FYPO:0000127 name: increased sensitivity to chemical during vegetative growth def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show decreased resistance to a chemical stimulus. Resistance to a chemical is measured by determining the maximum concentration of the chemical at which a population of cells grow and divide. Typically, cells are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type cells to grow." [PomBase:mah] synonym: "increased sensitivity to chemical during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to chemicals: decreased during vegetative growth" EXACT [PomBase:mah, SGD:phenotype_annotation] is_a: FYPO:0001358 ! vegetative cell population growth phenotype is_a: FYPO:0002683 ! increased sensitivity to chemical is_a: PATO:0001551 ! increased sensitivity of a process intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:24431 ! chemical entity relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:24431 ! chemical entity created_by: midori creation_date: 2011-03-29T05:54:40Z [Term] id: FYPO:0000128 name: auxotrophy def: "A phenotype in which a cell requires a particular organic compound, which is not required by a wild-type cell for its growth. Auxotrophy usually results from a cell's inability to synthesize the compound." [PATO:0000422, PomBase:mah] synonym: "auxotrophy during mitotic cell cycle" RELATED [PomBase:mah] synonym: "auxotrophy during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001358 ! vegetative cell population growth phenotype intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000422 ! auxotrophic relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000422 ! auxotrophic created_by: midori creation_date: 2011-03-29T05:54:40Z [Term] id: FYPO:0000129 name: spherical vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is formed in the shape of a sphere." [PomBase:mah] synonym: "orb during vegetative growth" EXACT [PomBase:jh, PomBase:vw] synonym: "spherical cells during vegetative growth" EXACT [PomBase:mah] synonym: "spherical vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000021 ! spheroid vegetative cell is_a: FYPO:0001956 ! spherical cell intersection_of: PATO:0001499 ! spherical intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) created_by: midori creation_date: 2011-03-29T05:54:40Z [Term] id: FYPO:0000130 name: short spindle def: "A spindle phenotype in which the spindle is shorter than normal." [PomBase:mah] synonym: "decreased spindle length" EXACT [PomBase:mah] synonym: "short spindles" EXACT [PomBase:mah] synonym: "spindle defects, short spindles" EXACT [PomBase:mah] is_a: FYPO:0003607 ! abnormal spindle morphology is_a: PATO:0000574 ! decreased length intersection_of: PATO:0000574 ! decreased length intersection_of: inheres_in GO:0005819 ! spindle relationship: inheres_in GO:0005819 ! spindle created_by: midori creation_date: 2011-03-29T05:54:40Z [Term] id: FYPO:0000131 name: abnormal mitotic spindle elongation def: "A spindle phenotype in which mitotic spindle elongation, i.e. the process of lengthening the distance between poles of the mitotic spindle, is abnormal." [GO:0000022, PomBase:mah] synonym: "abnormal mitotic spindle elongation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal spindle elongation during mitosis" EXACT [PomBase:mah] synonym: "spindle elongation defects" EXACT [PomBase:mah] is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0002737 ! abnormal mitotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000022 ! mitotic spindle elongation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000022 ! mitotic spindle elongation relationship: part_of FYPO:0000337 ! abnormal mitosis relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:54:40Z [Term] id: FYPO:0000132 name: abnormal septum disassembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which primary cell septum disassembly is abnormal; may result in the formation of chains of attached cells." [PomBase:mah] synonym: "abnormal septum disassembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal septum disassembly during vegetative growth" EXACT [PomBase:mah] synonym: "chained cells" RELATED [PomBase:mah] is_a: FYPO:0001353 ! abnormal cellular component organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0030994 ! primary cell septum disassembly intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0030994 ! primary cell septum disassembly relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:54:40Z [Term] id: FYPO:0000133 name: elongated multinucleate vegetative cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell contains more than one nucleus and is elongated." [PomBase:mah] synonym: "elongated multinucleate cell during vegetative growth" EXACT [PomBase:mah] synonym: "elongated multinucleate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "long multinucleate vegetative cell" EXACT [PomBase:vw] is_a: FYPO:0003342 ! elongated multinucleate cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000061 ! multinucleate vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000061 ! multinucleate vegetative cell relationship: output_of FYPO:0000032 ! abnormal cytokinesis created_by: midori creation_date: 2011-03-29T05:54:40Z [Term] id: FYPO:0000134 name: branched, elongated, multiseptate cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell forms one or more branches near a septum, is elongated, and has more than one septum." [PomBase:mah] synonym: "branched, elongated, multiseptate cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "branched, elongated, multiseptate cell during vegetative growth" EXACT [PomBase:mah] synonym: "branched, long, multiseptate cell" EXACT [PomBase:vw] is_a: FYPO:0000223 ! elongated multiseptate vegetative cell is_a: FYPO:0004594 ! branched, elongated, septated cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000015 ! branched vegetative cell intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000118 ! multiseptate vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000015 ! branched vegetative cell relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000118 ! multiseptate vegetative cell created_by: midori creation_date: 2011-03-29T05:54:40Z [Term] id: FYPO:0000135 name: abnormal plasma membrane sterol distribution def: "A localization phenotype observed in the vegetative growth phase of the life cycle in which the distribution of sterols in the plasma membrane is abnormal." [PomBase:mah] synonym: "abnormal plasma membrane sterol distribution during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal plasma membrane sterol distribution during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal regulation of plasma membrane sterol distribution" EXACT [PomBase:mah] synonym: "localization defects, sterol distribution defects" EXACT [PomBase:mah] is_a: FYPO:0000813 ! abnormal plasma membrane organization is_a: FYPO:0001334 ! regulation phenotype during vegetative growth is_a: FYPO:0001337 ! localization phenotype during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0097036 ! regulation of plasma membrane sterol distribution intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0097036 ! regulation of plasma membrane sterol distribution relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-03-29T05:54:40Z [Term] id: FYPO:0000136 name: cellular physical quality phenotype def: "A phenotype that affects any physical object quality, such as morphology, number, location, etc., of a cell or a cellular component." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "cellular physical object quality phenotype" EXACT [PATO:0001241] synonym: "fission yeast cellular physical object quality phenotype" EXACT [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype is_a: PATO:0001241 ! physical object quality intersection_of: PATO:0001241 ! physical object quality intersection_of: inheres_in_part_of GO:0005575 ! cellular_component relationship: inheres_in_part_of GO:0005575 ! cellular_component created_by: midori creation_date: 2011-04-12T12:01:21Z [Term] id: FYPO:0000137 name: mitotic cell cycle checkpoint phenotype def: "A cell phenotype that affects any mitotic cell cycle checkpoint." [PomBase:mah] subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast mitotic cell cycle checkpoint phenotype" EXACT [PomBase:mah] is_a: FYPO:0000631 ! cell cycle phenotype is_a: FYPO:0001334 ! regulation phenotype during vegetative growth intersection_of: FYPO:0000002 ! cell phenotype intersection_of: inheres_in_part_of GO:0007093 ! mitotic cell cycle checkpoint relationship: inheres_in_part_of GO:0007093 ! mitotic cell cycle checkpoint created_by: midori creation_date: 2011-04-12T12:55:38Z [Term] id: FYPO:0000138 name: localization phenotype def: "A cell phenotype that affects the localization of a structure or substance in a cell." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast localization phenotype" EXACT [PomBase:mah] synonym: "localisation phenotype" EXACT [PomBase:mah] is_a: FYPO:0000114 ! cellular process phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: inheres_in_part_of GO:0051641 ! cellular localization relationship: inheres_in_part_of GO:0051641 ! cellular localization created_by: midori creation_date: 2011-04-12T02:16:04Z [Term] id: FYPO:0000139 name: cell population growth phenotype def: "A cell phenotype that affects the rate or extent of cell population growth." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast cell population growth phenotype" EXACT [PomBase:mah] is_a: FYPO:0000003 ! cell population phenotype created_by: midori creation_date: 2011-04-12T02:22:51Z [Term] id: FYPO:0000140 name: cellular metabolism phenotype def: "A cellular process phenotype that affects metabolism in the cell." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast cellular metabolism phenotype" EXACT [PomBase:mah] is_a: FYPO:0000114 ! cellular process phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: inheres_in_part_of GO:0044237 ! cellular metabolic process relationship: inheres_in_part_of GO:0044237 ! cellular metabolic process created_by: midori creation_date: 2011-04-12T02:23:26Z [Term] id: FYPO:0000141 name: abnormal mitotic sister chromatid segregation alt_id: FYPO:0001359 def: "A cellular process phenotype in which mitotic sister chromatid segregation is abnormal. Mitotic sister chromatid segregation is the entire process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle." [GO:0000070, PomBase:mah] synonym: "abnormal chromosome segregation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal mitotic chromosome segregation" EXACT [PomBase:mah] synonym: "abnormal mitotic sister chromatid segregation during vegetative growth" EXACT [PomBase:mah] synonym: "centromere function defective during vegetative growth" RELATED [PomBase:mah] synonym: "chromosome segregation defects during vegetative growth" EXACT [PomBase:mah] synonym: "chromosome segregation defects, mitotic" EXACT [PomBase:mah] is_a: FYPO:0000029 ! abnormal chromosome segregation is_a: FYPO:0000641 ! abnormal chromosome organization is_a: FYPO:0001353 ! abnormal cellular component organization during vegetative growth is_a: FYPO:0002737 ! abnormal mitotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000070 ! mitotic sister chromatid segregation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000070 ! mitotic sister chromatid segregation relationship: part_of FYPO:0000337 ! abnormal mitosis relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-12T05:41:15Z [Term] id: FYPO:0000142 name: gene expression phenotype def: "A cellular process phenotype that affects gene expression. Gene expression includes transcription, RNA processing, and, for protein-coding genes, translation and protein maturation." [GO:0010467, PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast gene expression phenotype" EXACT [PomBase:mah] is_a: FYPO:0000114 ! cellular process phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: inheres_in_part_of GO:0010467 ! gene expression relationship: inheres_in_part_of GO:0010467 ! gene expression created_by: midori creation_date: 2011-04-12T05:46:51Z [Term] id: FYPO:0000143 name: transcription regulation phenotype def: "A gene expression phenotype that affects the regulation of DNA-dependent transcription." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast transcription regulation phenotype" EXACT [PomBase:mah] synonym: "gene-specific transcription regulation phenotype" RELATED [GO:0006355, PomBase:mah] synonym: "transcriptional control phenotype" BROAD [GO:0006355, PomBase:mah] is_a: FYPO:0000288 ! gene expression regulation phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: inheres_in_part_of GO:0006355 ! regulation of transcription, DNA-templated relationship: inheres_in_part_of GO:0006355 ! regulation of transcription, DNA-templated created_by: midori creation_date: 2011-04-12T05:47:38Z [Term] id: FYPO:0000144 name: abnormal chromatin silencing def: "A transcription regulation phenotype observed in the vegetative growth phase of the life cycle in which chromatin silencing is abnormal. Chromatin silencing is repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into heterochromatin." [GO:0006342, PomBase:mah] synonym: "abnormal chromatin silencing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal chromatin silencing during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000574 ! abnormal gene silencing is_a: FYPO:0000624 ! abnormal negative regulation of transcription during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006342 ! chromatin silencing intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006342 ! chromatin silencing relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-12T05:48:37Z [Term] id: FYPO:0000145 name: regulation phenotype def: "A cellular process phenotype that affects the regulation of a molecular function, biological process, or biological quality." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast regulation phenotype" EXACT [PomBase:mah] is_a: FYPO:0000114 ! cellular process phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: inheres_in_part_of GO:0065007 ! biological regulation relationship: inheres_in_part_of GO:0065007 ! biological regulation created_by: midori creation_date: 2011-04-12T06:00:44Z [Term] id: FYPO:0000146 name: abnormal chromatin silencing at centromere def: "A transcription regulation phenotype observed in the vegetative growth phase of the life cycle in which chromatin silencing at centromeric regions is abnormal." [PomBase:mah] synonym: "abnormal chromatin silencing at centromere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal chromatin silencing at centromere during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal heterochromatin silencing at centromere" RELATED [PomBase:mah] is_a: FYPO:0000144 ! abnormal chromatin silencing intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0030702 ! chromatin silencing at centromere intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0030702 ! chromatin silencing at centromere relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:34:54Z [Term] id: FYPO:0000147 name: abnormal activation of bipolar cell growth def: "A regulation phenotype observed in the vegetative growth phase of the life cycle in which activation of bipolar cell growth is abnormal; results in abnormal new end take-off." [PomBase:mah] synonym: "abnormal activation of bipolar vegetative cell growth" EXACT [PomBase:mah] synonym: "abnormal NETO" EXACT [PomBase:mah] synonym: "abnormal new end take off" EXACT [PomBase:mah] is_a: FYPO:0000191 ! abnormal regulation of establishment or maintenance of cell polarity is_a: FYPO:0001392 ! abnormal regulation of cell growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0051519 ! activation of bipolar cell growth intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0051519 ! activation of bipolar cell growth relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:34:54Z [Term] id: FYPO:0000148 name: abnormal regulation of mitotic cell cycle def: "A regulation phenotype in which regulation of the mitotic cell cycle is abnormal." [PomBase:mah] is_a: FYPO:0000059 ! abnormal mitotic cell cycle is_a: FYPO:0001334 ! regulation phenotype during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0007346 ! regulation of mitotic cell cycle intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0007346 ! regulation of mitotic cell cycle relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:34:54Z [Term] id: FYPO:0000149 name: transport phenotype def: "A cell process phenotype that affects a transport process." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast transport phenotype" EXACT [PomBase:mah] is_a: FYPO:0000138 ! localization phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: inheres_in_part_of GO:0006810 ! transport relationship: inheres_in_part_of GO:0006810 ! transport created_by: midori creation_date: 2011-04-14T05:43:20Z [Term] id: FYPO:0000150 name: abnormal colony morphology def: "A cell population phenotype in which the morphology, i.e. the size, shape, or structure, of a colony growing on a solid surface is abnormal." [PomBase:mah] synonym: "colony shape: abnormal" RELATED [SGD:phenotype_annotation] is_a: FYPO:0000003 ! cell population phenotype is_a: FYPO:0001985 ! abnormal phenotype created_by: midori creation_date: 2011-04-19T02:50:53Z [Term] id: FYPO:0000151 name: abnormal meiotic chromosome segregation def: "A cellular process phenotype in which meiotic chromosome segregation is abnormal. Meiotic chromosome segregation is the entire process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle." [GO:0045132, PomBase:mah] is_a: FYPO:0000029 ! abnormal chromosome segregation is_a: FYPO:0002739 ! abnormal meiotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0045132 ! meiotic chromosome segregation intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0045132 ! meiotic chromosome segregation relationship: part_of FYPO:0000051 ! abnormal meiosis relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:34:54Z [Term] id: FYPO:0000152 name: abnormal cellular response to nitrogen starvation def: "A stress response phenotype in which the response to nitrogen starvation is abnormal." [PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. Use this term if you have assayed the response to nitrogen starvation at the subcellular or molecular level. If you have assayed growth of cells exposed to nitrogen starvation in culture, use 'sensitive to nitrogen starvation' (FYPO:0002124). synonym: "abnormal cellular response to nitrogen depletion" EXACT [PomBase:vw] synonym: "abnormal cellular response to nitrogen deprivation" EXACT [PomBase:vw] is_a: FYPO:0000713 ! abnormal cellular response to starvation intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0006995 ! cellular response to nitrogen starvation intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0006995 ! cellular response to nitrogen starvation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:34:54Z [Term] id: FYPO:0000153 name: clumped colony morphology def: "A colony morphology phenotype in which cells form clumps. Clumping may result from incomplete hydrolysis of septum edging material, causing cells to remain attached via remnants of the septum edging, or from cell-cell adhesion between cells that do not have a shared origin." [PMID:15194814, PomBase:ch, PomBase:mah] comment: This term was made obsolete because it was added to map an out-of-date controlled vocabulary term, and unhelpfully groups two fairly unrelated phenomena. is_obsolete: true created_by: midori creation_date: 2011-04-19T02:50:53Z [Term] id: FYPO:0000154 name: abnormal negative regulation of G0 to G1 transition def: "A regulation phenotype in which negative regulation of the G0 to G1 transition is abnormal." [PomBase:mah] synonym: "abnormal maintenance of cell cycle quiescence" EXACT [PomBase:mah] synonym: "abnormal maintenance of cell quiescence" EXACT [PomBase:mah] synonym: "abnormal maintenance of G0 arrest" EXACT [PomBase:mah] synonym: "abnormal maintenance of G0 phase" EXACT [PomBase:mah] is_a: FYPO:0000145 ! regulation phenotype is_a: FYPO:0000628 ! abnormal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0070317 ! negative regulation of G0 to G1 transition intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0070317 ! negative regulation of G0 to G1 transition relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:34:54Z [Term] id: FYPO:0000155 name: increased flocculation alt_id: FYPO:0000462 def: "A cell population phenotype that reflects increased occurrence of flocculation. Flocculation is the non-sexual aggregation of single cells." [GO:0000128, PomBase:mah] synonym: "flocculating cells" EXACT [PomBase:mah] synonym: "flocculation: increased" EXACT [SGD:phenotype_annotation] synonym: "increased cell-cell adhesion" BROAD [PomBase:mah, PomBase:vw] is_a: FYPO:0000003 ! cell population phenotype is_a: FYPO:0000300 ! biological process phenotype is_a: FYPO:0001985 ! abnormal phenotype is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0000128 ! flocculation relationship: inheres_in GO:0000128 ! flocculation created_by: midori creation_date: 2011-04-19T02:50:53Z [Term] id: FYPO:0000156 name: abnormal chromatin silencing at silent mating-type cassette def: "A transcription regulation phenotype observed in the vegetative growth phase of the life cycle in which chromatin silencing at the silent mating-type cassettes is abnormal." [PomBase:mah] synonym: "abnormal chromatin silencing at silent mating-type cassette during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal chromatin silencing at silent mating-type cassette during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000144 ! abnormal chromatin silencing intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0030466 ! chromatin silencing at silent mating-type cassette intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0030466 ! chromatin silencing at silent mating-type cassette relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:34:54Z [Term] id: FYPO:0000157 name: abnormal response to DNA damage stimulus def: "A stress response phenotype observed in the vegetative growth phase of the life cycle in which the response to DNA damage is abnormal." [PomBase:mah] comment: Use this term if you have assayed the response to DNA damage at the subcellular or molecular level. If you have assayed growth of cells exposed to DNA damage in culture, use 'sensitive to DNA damage' (FYPO:0000265). Also consider specific phenotype terms for sensitivity to substances or other stimuli that can damage DNA, e.g. 'sensitive to DNA damaging agents' (FYPO:0000266), 'sensitive to methyl methanesulfonate' (FYPO:0000089), 'sensitive to UV' (FYPO:0000268), etc. synonym: "abnormal response to DNA damage stimulus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal response to DNA damage stimulus during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001341 ! abnormal cellular response to stress during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006974 ! cellular response to DNA damage stimulus intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006974 ! cellular response to DNA damage stimulus relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:34:54Z [Term] id: FYPO:0000158 name: DNA content increased during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the total amount of DNA in a cell is greater than normal." [PomBase:mah] synonym: "DNA content increased during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased DNA content during vegetative growth" EXACT [PomBase:mah] synonym: "increased DNA level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth is_a: FYPO:0002729 ! DNA content increased is_a: FYPO:0004321 ! altered DNA level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:16991 ! deoxyribonucleic acid relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:16991 ! deoxyribonucleic acid created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000159 name: abnormal chromosome condensation alt_id: FYPO:0000028 def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which chromosome condensation is abnormal. Chromosome condensation is the progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division." [GO:0030261, PomBase:mah] synonym: "abnormal chromosome condensation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal chromosome condensation during vegetative growth" EXACT [PomBase:mah] synonym: "chromosome condensation defects" EXACT [PomBase:mah] is_a: FYPO:0000293 ! DNA metabolism phenotype is_a: FYPO:0000641 ! abnormal chromosome organization is_a: FYPO:0000860 ! abnormal metabolic process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0030261 ! chromosome condensation intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0030261 ! chromosome condensation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-14T10:44:38Z [Term] id: FYPO:0000160 name: fragmented DNA def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which DNA is broken into small fragments." [PomBase:mah] synonym: "DNA fragmentation" EXACT [PomBase:mah] synonym: "fragmented DNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "fragmented DNA during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000287 ! abnormal subcellular component is_a: PATO:0001444 ! broken intersection_of: PATO:0001444 ! broken intersection_of: inheres_in CHEBI:16991 ! deoxyribonucleic acid relationship: inheres_in CHEBI:16991 ! deoxyribonucleic acid created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000161 name: abnormal actomyosin contractile ring assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which contractile ring assembly is abnormal." [PomBase:mah] synonym: "abnormal actomyosin contractile ring assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal actomyosin contractile ring assembly during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal actomyosin contractile ring formation" RELATED [GO:0000915, PomBase:mah] synonym: "abnormal contractile ring assembly" EXACT [PomBase:mah] synonym: "abnormal cytokinesis, actomyosin contractile ring assembly" EXACT [PomBase:mah] synonym: "abnormal cytokinetic contractile ring assembly" EXACT [PomBase:vw] synonym: "abnormal cytokinetic ring assembly" RELATED [PomBase:vw] synonym: "abnormal cytokinetic ring formation" RELATED [PomBase:vw] synonym: "abnormal mitotic contractile ring assembly" EXACT [PomBase:vw] is_a: FYPO:0000032 ! abnormal cytokinesis is_a: FYPO:0004738 ! abnormal actomyosin contractile ring organization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000915 ! actomyosin contractile ring assembly intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000915 ! actomyosin contractile ring assembly relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:34:54Z [Term] id: FYPO:0000162 name: abnormal cellular response to stress def: "A cellular response phenotype in which a cellular response to stress is abnormal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. Use a descendant of this term if you have assayed the response to a stress at the subcellular or molecular level. If you have assayed growth of cells exposed to the stress in culture, use a descendant of 'sensitive to stress' (FYPO:0002549) or 'resistance to stress' (FYPO:0002046). subset: qc_do_not_manually_annotate is_a: FYPO:0000298 ! cellular response phenotype is_a: FYPO:0000628 ! abnormal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0033554 ! cellular response to stress intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0033554 ! cellular response to stress relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:34:54Z [Term] id: FYPO:0000163 name: abnormal autophagy alt_id: FYPO:0000379 def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which autophagy is abnormal. Autophagy is the process in which cells digest parts of their own cytoplasm." [GO:0006914, PomBase:mah] synonym: "autophagy: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000860 ! abnormal metabolic process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0006914 ! autophagy intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0006914 ! autophagy relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:34:54Z [Term] id: FYPO:0000164 name: abnormal cell separation after cytokinesis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which cell separation after cytokinesis is abnormal. Cell separation is the process of physically separating progeny cells after cytokinesis is complete, and involves enzymatic digestion of septum components." [GO:0000920, PomBase:mah] synonym: "abnormal cell separation after cytokinesis during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal mitotic cytokinetic cell separation" EXACT [GO:0000920, PomBase:mah] is_a: FYPO:0000032 ! abnormal cytokinesis intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000920 ! cell separation after cytokinesis intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000920 ! cell separation after cytokinesis relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:34:54Z [Term] id: FYPO:0000165 name: abnormal regulation of conjugation def: "A regulation phenotype in which regulation of conjugation is abnormal." [PomBase:mah] synonym: "abnormal regulation of conjugation with cellular fusion" EXACT [PomBase:mah] is_a: FYPO:0000145 ! regulation phenotype is_a: FYPO:0000628 ! abnormal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0031137 ! regulation of conjugation with cellular fusion intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0031137 ! regulation of conjugation with cellular fusion relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:34:54Z [Term] id: FYPO:0000166 name: abnormal regulation of G2/M transition of mitotic cell cycle def: "A regulation phenotype in which negative regulation of the G2 to M transition of the mitotic cell cycle is abnormal." [PomBase:mah] is_a: FYPO:0000148 ! abnormal regulation of mitotic cell cycle intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0010389 ! regulation of G2/M transition of mitotic cell cycle intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0010389 ! regulation of G2/M transition of mitotic cell cycle relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:34:54Z [Term] id: FYPO:0000167 name: increased DNA recombination at mitotic DNA replication fork barriers def: "A cellular process phenotype in which the frequency of DNA recombination at replication fork barriers is increased." [PomBase:mah] synonym: "DNA recombination defect, at mitotic DNA replication fork barriers, elevated" EXACT [PomBase:mah] synonym: "increased DNA recombination at mitotic DNA replication fork barriers during vegetative growth" EXACT [PomBase:mah] synonym: "increased recombination at mitotic DNA replication fork barriers" EXACT [PomBase:vw] is_a: FYPO:0001345 ! abnormal DNA recombination during vegetative growth created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000168 name: abnormal mitotic cell cycle spindle assembly checkpoint def: "A cell cycle checkpoint phenotype in which the spindle assembly checkpoint of a mitotic cell cycle is abnormal. The mitotic spindle assembly checkpoint normally delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle. In a mutant, the checkpoint may fail to arrest or delay cell cycle progression under appropriate conditions, or the incidence or duration of arrest or delay may differ from wild type under any specified set of conditions." [GO:0007094, PomBase:mah] synonym: "abnormal mitotic cell cycle spindle assembly checkpoint activation" RELATED [PomBase:mah] is_a: FYPO:0000200 ! abnormal regulation of mitotic metaphase/anaphase transition is_a: FYPO:0000682 ! abnormal regulation of molecular function is_a: FYPO:0001704 ! abnormal mitotic cell cycle checkpoint intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0007094 ! mitotic spindle assembly checkpoint intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0007094 ! mitotic spindle assembly checkpoint relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:34:54Z [Term] id: FYPO:0000169 name: abnormal chromatin silencing at telomere def: "A transcription regulation phenotype observed in the vegetative growth phase of the life cycle in which chromatin silencing at telomeric regions is abnormal." [PomBase:mah] synonym: "abnormal chromatin silencing at telomere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal chromatin silencing at telomere during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000144 ! abnormal chromatin silencing intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006348 ! chromatin silencing at telomere intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006348 ! chromatin silencing at telomere relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:34:54Z [Term] id: FYPO:0000171 name: abnormal late endosome to vacuole transport def: "A transport phenotype observed in the vegetative growth phase of the life cycle in which late endosome to vacuole transport is abnormal." [PomBase:mah] synonym: "abnormal late endosome to vacuole transport during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal late endosome to vacuole transport during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000213 ! abnormal vesicle-mediated transport during vegetative growth is_a: FYPO:0000597 ! abnormal vacuolar transport during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0045324 ! late endosome to vacuole transport intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0045324 ! late endosome to vacuole transport relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:34:54Z [Term] id: FYPO:0000172 name: abnormal meiotic telomere clustering def: "A meiosis phenotype in which meiotic telomere clustering is abnormal. Meiotic telomere clustering is the dynamic reorganization of telomeres in early meiotic prophase, during which meiotic chromosome ends are gathered in a bouquet arrangement at the inner surface of the nuclear envelope proximal to the spindle pole body." [GO:0045141, PomBase:mah] is_a: FYPO:0000051 ! abnormal meiosis is_a: FYPO:0000138 ! localization phenotype is_a: FYPO:0000641 ! abnormal chromosome organization intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0045141 ! meiotic telomere clustering intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0045141 ! meiotic telomere clustering relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:34:54Z [Term] id: FYPO:0000173 name: abnormal mitotic cell cycle DNA replication checkpoint alt_id: FYPO:0000823 def: "A cell cycle checkpoint phenotype in which the DNA replication checkpoint in a mitotic cell cycle is abnormal. The DNA replication checkpoint normally prevents the initiation of mitosis until DNA replication is complete. In a mutant, the checkpoint may fail to arrest or delay cell cycle progression under appropriate conditions, or the incidence or duration of arrest or delay may differ from wild type under any specified set of conditions." [PomBase:mah] synonym: "abnormal DNA replication checkpoint" BROAD [PomBase:mah] synonym: "abnormal mitotic cell cycle DNA replication checkpoint activation" EXACT [PomBase:mah] is_a: FYPO:0000166 ! abnormal regulation of G2/M transition of mitotic cell cycle is_a: FYPO:0000643 ! abnormal mitotic DNA integrity checkpoint intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0033314 ! mitotic DNA replication checkpoint intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0033314 ! mitotic DNA replication checkpoint relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:34:54Z [Term] id: FYPO:0000174 name: abnormal cell wall biogenesis def: "A cellular process phenotype in which cell wall biogenesis is abnormal." [PomBase:mah] synonym: "abnormal fungal-type cell wall biogenesis" EXACT [GO:0009272, PomBase:mah] is_a: FYPO:0000628 ! abnormal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0009272 ! fungal-type cell wall biogenesis intersection_of: qualifier PATO:0000460 ! abnormal relationship: has_output FYPO:0002946 ! abnormal cell wall relationship: inheres_in_part_of GO:0009272 ! fungal-type cell wall biogenesis relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:34:54Z [Term] id: FYPO:0000175 name: abnormal ascospore wall assembly def: "A sporulation phenotype in which ascospore wall assembly is abnormal." [PomBase:mah] synonym: "abnormal ascospore wall organization" RELATED [PomBase:mah] synonym: "abnormal spore wall formation" RELATED [PomBase:mah] synonym: "spore wall formation: abnormal" RELATED [SGD:phenotype_annotation] is_a: FYPO:0000336 ! abnormal cellular component assembly is_a: FYPO:0000679 ! developmental process phenotype is_a: FYPO:0002739 ! abnormal meiotic cell cycle process is_a: FYPO:0004805 ! abnormal cell wall organization intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0030476 ! ascospore wall assembly intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0030476 ! ascospore wall assembly relationship: part_of FYPO:0000121 ! abnormal sporulation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:34:54Z [Term] id: FYPO:0000176 name: abnormal DNA replication initiation def: "A cellular process phenotype in which the initiation of DNA replication is abnormal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "abnormal DNA-dependent DNA replication initiation" EXACT [PomBase:mah] is_a: FYPO:0000217 ! abnormal DNA replication intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0006270 ! DNA replication initiation intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0006270 ! DNA replication initiation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:34:54Z [Term] id: FYPO:0000177 name: abnormal mitotic spindle assembly alt_id: FYPO:0001349 def: "A cellular process phenotype in which assembly of the mitotic spindle is abnormal. Spindle assembly is the aggregation, arrangement and bonding together of a set of components to form the spindle." [PomBase:mah] synonym: "abnormal bipolar spindle formation" EXACT [GO:0051225] synonym: "abnormal mitotic spindle assembly during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal spindle assembly during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000119 ! abnormal spindle assembly is_a: FYPO:0001350 ! abnormal microtubule cytoskeleton organization during vegetative growth is_a: FYPO:0001354 ! abnormal cellular component assembly during vegetative growth is_a: FYPO:0002737 ! abnormal mitotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0090307 ! mitotic spindle assembly intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_output FYPO:0000338 ! abnormal mitotic spindle relationship: inheres_in_part_of GO:0090307 ! mitotic spindle assembly relationship: part_of FYPO:0000337 ! abnormal mitosis relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:34:54Z [Term] id: FYPO:0000178 name: abnormal regulation of cytokinesis def: "A regulation phenotype observed in the vegetative growth phase of the life cycle in which regulation of cytokinesis is abnormal." [PomBase:mah] synonym: "abnormal regulation of cytokinesis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal regulation of cytokinesis during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal regulation of mitotic cytokinesis" EXACT [PomBase:mah] is_a: FYPO:0001334 ! regulation phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0032465 ! regulation of cytokinesis intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0032465 ! regulation of cytokinesis relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:34:54Z [Term] id: FYPO:0000179 name: abnormal protein targeting via MVB pathway def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which protein targeting to the vacuole via the multivesicular sorting pathway, leading to ubiquitin-dependent protein degradation, is abnormal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway" EXACT [PomBase:mah] synonym: "abnormal protein targeting via multivesicular body sorting pathway" EXACT [PomBase:mah] synonym: "abnormal protein targeting via MVB pathway during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein targeting via the multivesicular body sorting pathway during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000171 ! abnormal late endosome to vacuole transport is_a: FYPO:0000676 ! abnormal protein targeting to vacuole intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0043328 ! protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0043328 ! protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:34:54Z [Term] id: FYPO:0000180 name: abnormal cellular response to oxidative stress def: "A stress response phenotype in which a cellular response to oxidative stress is abnormal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate is_a: FYPO:0000162 ! abnormal cellular response to stress intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0034599 ! cellular response to oxidative stress intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0034599 ! cellular response to oxidative stress relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:34:54Z [Term] id: FYPO:0000181 name: abolished crossover def: "A DNA recombination phenotype observed in the vegetative growth phase of the life cycle in which reciprocal DNA recombination does not occur." [PomBase:mah] synonym: "abolished crossover during mitotic cell cycle" RELATED [PomBase:mah] synonym: "crossover abolished" EXACT [PomBase:mah] synonym: "crossover abolished during vegetative growth" EXACT [PomBase:mah] synonym: "DNA recombination defects, crossover, abolished" EXACT [PomBase:mah] is_a: FYPO:0001345 ! abnormal DNA recombination during vegetative growth is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0035825 ! reciprocal DNA recombination relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0035825 ! reciprocal DNA recombination created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000182 name: abnormal cell wall organization during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which cell wall organization is abnormal. Cell wall organization results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall." [GO:0031505, PomBase:mah] synonym: "abnormal cell wall organisation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal cell wall organization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal fungal-type cell wall organization during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001353 ! abnormal cellular component organization during vegetative growth is_a: FYPO:0004805 ! abnormal cell wall organization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0031505 ! fungal-type cell wall organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0031505 ! fungal-type cell wall organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:34:54Z [Term] id: FYPO:0000183 name: abnormal poly(A)+ mRNA export from nucleus def: "A transport phenotype observed in the vegetative growth phase of the life cycle in which the export of polyadenylated mRNA from the nucleus is abnormal." [PomBase:mah] synonym: "abnormal poly(A)+ mRNA export from nucleus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal poly(A)+ mRNA export from nucleus during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000204 ! abnormal mRNA export from nucleus intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0016973 ! poly(A)+ mRNA export from nucleus intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0016973 ! poly(A)+ mRNA export from nucleus relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:34:54Z [Term] id: FYPO:0000184 name: abnormal regulation of pseudohyphal growth def: "A regulation phenotype in which regulation of pseudohyphal growth is abnormal." [PomBase:mah] synonym: "abnormal regulation of filamentous growth" BROAD [PomBase:mah] is_a: FYPO:0000145 ! regulation phenotype is_a: FYPO:0000628 ! abnormal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0010570 ! regulation of filamentous growth intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0010570 ! regulation of filamentous growth relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:34:54Z [Term] id: FYPO:0000185 name: decreased gene conversion def: "A DNA recombination phenotype observed in the vegetative growth phase of the life cycle in which gene conversion occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased gene conversion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased gene conversion during vegetative growth" EXACT [PomBase:mah] synonym: "DNA recombination defects, gene conversion, reduced" EXACT [PomBase:mah] synonym: "reduced gene conversion" EXACT [PomBase:mah] is_a: FYPO:0002340 ! decreased DNA recombination during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0035822 ! gene conversion relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0035822 ! gene conversion creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000186 name: abnormal cell division def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which cell division is abnormal." [PomBase:mah] subset: qc_do_not_manually_annotate synonym: "abnormal cell division during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal cell division during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0051301 ! cell division intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0051301 ! cell division relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:41:10Z [Term] id: FYPO:0000187 name: abnormal chromatin silencing by small RNA def: "A transcription regulation phenotype observed in the vegetative growth phase of the life cycle in which chromatin silencing mediated by small RNA is abnormal." [PomBase:mah] synonym: "abnormal chromatin silencing by small RNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal chromatin silencing by small RNA during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000144 ! abnormal chromatin silencing intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0031048 ! chromatin silencing by small RNA intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0031048 ! chromatin silencing by small RNA relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:41:10Z [Term] id: FYPO:0000188 name: abnormal DNA repair def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which DNA repair is abnormal." [PomBase:mah] synonym: "abnormal DNA repair during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal DNA repair during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000157 ! abnormal response to DNA damage stimulus is_a: FYPO:0001346 ! DNA metabolism phenotype during vegetative growth is_a: FYPO:0001363 ! abnormal metabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006281 ! DNA repair intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006281 ! DNA repair relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:41:10Z [Term] id: FYPO:0000189 name: abnormal mRNA splicing, via spliceosome def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mRNA splicing via the spliceosome is abnormal." [PomBase:mah] synonym: "abnormal mRNA splicing, via spliceosome during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal mRNA splicing, via spliceosome during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal nuclear mRNA splicing, via spliceosome" EXACT [PomBase:mah] is_a: FYPO:0002915 ! abnormal RNA splicing intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000398 ! mRNA splicing, via spliceosome intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000398 ! mRNA splicing, via spliceosome relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:41:10Z [Term] id: FYPO:0000190 name: abnormal actin cortical patch localization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which actin cortical patch localization is abnormal." [PomBase:mah] synonym: "abnormal actin cortical patch localisation" EXACT [PomBase:mah] synonym: "abnormal actin cortical patch localization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal actin cortical patch localization during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal actin cortical patch location" RELATED [PomBase:mah] synonym: "abnormal actin patch localization" EXACT [PomBase:vw] is_a: FYPO:0000801 ! abnormal actin cytoskeleton organization during vegetative growth is_a: FYPO:0001337 ! localization phenotype during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0051666 ! actin cortical patch localization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0051666 ! actin cortical patch localization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:41:10Z [Term] id: FYPO:0000191 name: abnormal regulation of establishment or maintenance of cell polarity def: "A regulation phenotype observed in the vegetative growth phase of the life cycle in which regulation of the establishment or maintenance of cell polarity is abnormal." [PomBase:mah] synonym: "abnormal regulation of establishment or maintenance of cell polarity during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal regulation of establishment or maintenance of cell polarity during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001334 ! regulation phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0032878 ! regulation of establishment or maintenance of cell polarity intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0032878 ! regulation of establishment or maintenance of cell polarity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:41:10Z [Term] id: FYPO:0000192 name: abnormal regulation of S phase of mitotic cell cycle def: "A regulation phenotype in which regulation of progression through S phase of the mitotic cell cycle is abnormal." [PomBase:mah] comment: This term was made obsolete because it was based on a GO term (GO:0007090) that has itself been made obsolete. is_obsolete: true created_by: midori creation_date: 2011-04-13T03:41:10Z [Term] id: FYPO:0000193 name: abnormal cellular response to osmotic stress def: "A stress response phenotype observed in the vegetative growth phase of the life cycle in which a cellular response to osmotic stress is abnormal." [PomBase:mah] comment: Use this term if you have assayed the response to osmotic stress at the subcellular or molecular level. If you have assayed growth of cells exposed to osmotic stress in culture, use 'sensitive to osmotic stress' (FYPO:0000270) or 'resistance to osmotic stress' (FYPO:0000851). synonym: "abnormal cellular response to osmotic stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal cellular response to osmotic stress during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001341 ! abnormal cellular response to stress during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0071470 ! cellular response to osmotic stress intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0071470 ! cellular response to osmotic stress relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:41:10Z [Term] id: FYPO:0000194 name: abnormal cellular response to hydrogen peroxide def: "A stress response phenotype observed in the vegetative growth phase of the life cycle in which a cellular response to hydrogen peroxide is abnormal." [PomBase:mah] synonym: "abnormal cellular response to H2O2" EXACT [PomBase:mah] synonym: "abnormal cellular response to hydrogen peroxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal cellular response to hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001340 ! abnormal cellular response to oxidative stress during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0070301 ! cellular response to hydrogen peroxide intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0070301 ! cellular response to hydrogen peroxide relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:41:10Z [Term] id: FYPO:0000196 name: abnormal prospore formation def: "A sporulation phenotype in which prospore formation is abnormal. In prospore formation, each haploid nucleus becomes encapsulated by a double membrane." [PomBase:mah] synonym: "abnormal ascospore-type prospore assembly" EXACT [GO:0031321] synonym: "abnormal ascospore-type prospore formation" EXACT [PomBase:mah] synonym: "abnormal forespore formation" EXACT [PomBase:mah] is_a: FYPO:0000336 ! abnormal cellular component assembly is_a: FYPO:0000679 ! developmental process phenotype is_a: FYPO:0002739 ! abnormal meiotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0031321 ! ascospore-type prospore assembly intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0031321 ! ascospore-type prospore assembly relationship: part_of FYPO:0000121 ! abnormal sporulation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:41:10Z [Term] id: FYPO:0000197 name: abnormal horsetail movement def: "A cellular process phenotype in which horsetail movement is abnormal. Horsetail movement is the oscillatory movement of the nucleus that takes place during meiotic prophase I." [GO:0030989, PomBase:mah] comment: Consider also annotating to 'abnormal horsetail nucleus morphology' (FYPO:0002890). synonym: "abnormal dynein-driven meiotic oscillatory nuclear movement" EXACT [GO:0030989, PomBase:mah] synonym: "abnormal horsetail nuclear movement" EXACT [GO:0030989, PomBase:mah] is_a: FYPO:0000517 ! abnormal nucleus localization is_a: FYPO:0001720 ! abnormal transport is_a: FYPO:0002739 ! abnormal meiotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0030989 ! dynein-driven meiotic oscillatory nuclear movement intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0030989 ! dynein-driven meiotic oscillatory nuclear movement relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:41:10Z [Term] id: FYPO:0000198 name: abnormal establishment or maintenance of actin cytoskeleton polarity def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the establishment or maintenance of actin cytoskeleton polarity is abnormal." [PomBase:mah] synonym: "abnormal establishment or maintenance of actin cytoskeleton polarity during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal establishment or maintenance of actin cytoskeleton polarity during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000026 ! abnormal cell polarity is_a: FYPO:0000801 ! abnormal actin cytoskeleton organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0030950 ! establishment or maintenance of actin cytoskeleton polarity intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0030950 ! establishment or maintenance of actin cytoskeleton polarity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:41:10Z [Term] id: FYPO:0000199 name: increased long tract gene conversion def: "A DNA recombination phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of long tract gene conversion is increased." [PomBase:mah] synonym: "DNA recombination defects, long tract gene conversion, increased" EXACT [PomBase:mah] synonym: "increased long tract gene conversion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased long tract gene conversion during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001345 ! abnormal DNA recombination during vegetative growth is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0035824 ! long tract gene conversion relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0035824 ! long tract gene conversion created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000200 name: abnormal regulation of mitotic metaphase/anaphase transition def: "A regulation phenotype in which regulation of the mitotic metaphase to anaphase transition is abnormal." [PomBase:mah] synonym: "abnormal regulation of mitotic metaphase/anaphase transition during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000148 ! abnormal regulation of mitotic cell cycle is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0030071 ! regulation of mitotic metaphase/anaphase transition intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0030071 ! regulation of mitotic metaphase/anaphase transition relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:41:10Z [Term] id: FYPO:0000201 name: abnormal histone deacetylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone deacetylation is abnormal." [PomBase:mah] synonym: "abnormal histone deacetylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal histone deacetylation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000330 ! abnormal histone modification is_a: FYPO:0004485 ! abnormal protein deacetylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0016575 ! histone deacetylation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0016575 ! histone deacetylation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:41:10Z [Term] id: FYPO:0000202 name: abnormal regulation of cytokinetic cell separation def: "A regulation phenotype observed in the vegetative growth phase of the life cycle in which regulation of cytokinetic cell separation is abnormal." [PomBase:mah] synonym: "abnormal regulation of cell separation after cytokinesis" EXACT [GO:0010590, PomBase:mah] synonym: "abnormal regulation of cell separation following cytokinesis" EXACT [GO:0010590, PomBase:mah] synonym: "abnormal regulation of cytokinetic cell separation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal regulation of mitotic cytokinetic cell separation" EXACT [GO:0010590, PomBase:mah] is_a: FYPO:0001334 ! regulation phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0010590 ! regulation of cell separation after cytokinesis intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0010590 ! regulation of cell separation after cytokinesis relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:41:10Z [Term] id: FYPO:0000203 name: abnormal ergosterol biosynthetic process def: "A metabolism phenotype observed in the vegetative growth phase of the life cycle in which ergosterol biosynthesis is abnormal." [PomBase:mah] synonym: "abnormal ergosterol biosynthesis" EXACT [PomBase:mah] synonym: "abnormal ergosterol biosynthetic process during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal ergosterol biosynthetic process during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001363 ! abnormal metabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006696 ! ergosterol biosynthetic process intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006696 ! ergosterol biosynthetic process relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:41:10Z [Term] id: FYPO:0000204 name: abnormal mRNA export from nucleus def: "A transport phenotype observed in the vegetative growth phase of the life cycle in which the export of mRNA from the nucleus is abnormal." [PomBase:mah] synonym: "abnormal mRNA export from nucleus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal mRNA export from nucleus during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000506 ! abnormal nuclear export intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006406 ! mRNA export from nucleus intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006406 ! mRNA export from nucleus relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:41:10Z [Term] id: FYPO:0000206 name: abnormal chromatin silencing at rDNA def: "A transcription regulation phenotype observed in the vegetative growth phase of the life cycle in which chromatin silencing at ribosomal DNA repeats is abnormal." [PomBase:mah] synonym: "abnormal chromatin silencing at rDNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal chromatin silencing at rDNA during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal chromatin silencing at ribosomal DNA" EXACT [PomBase:mah] is_a: FYPO:0000144 ! abnormal chromatin silencing intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000183 ! chromatin silencing at rDNA intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000183 ! chromatin silencing at rDNA relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:41:10Z [Term] id: FYPO:0000207 name: abnormal cellular response to caffeine def: "A cellular response phenotype observed in the vegetative growth phase of the life cycle in which the cellular response to caffeine is abnormal." [PomBase:mah] synonym: "abnormal cellular response to caffeine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal cellular response to caffeine during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001342 ! cellular response phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0071313 ! cellular response to caffeine intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0071313 ! cellular response to caffeine relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:41:10Z [Term] id: FYPO:0000208 name: abnormal cellular response to cadmium ion def: "A cellular response phenotype observed in the vegetative growth phase of the life cycle in which the cellular response to cadmium ions is abnormal." [PomBase:mah] synonym: "abnormal cellular response to cadmium ion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal cellular response to cadmium ion during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001342 ! cellular response phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0071276 ! cellular response to cadmium ion intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0071276 ! cellular response to cadmium ion relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:41:10Z [Term] id: FYPO:0000209 name: abnormal attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation def: "A cellular process phenotype in which the attachment of spindle microtubules to the kinetochore during the first meiotic division is abnormal." [PomBase:mah] is_a: FYPO:0000325 ! abnormal attachment of spindle microtubules to kinetochore is_a: FYPO:0002739 ! abnormal meiotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0051455 ! attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0051455 ! attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:41:10Z [Term] id: FYPO:0000211 name: abnormal cellular response to drug def: "A chemical response phenotype observed in the vegetative growth phase of the life cycle in which the cellular response to a chemical is abnormal." [PomBase:mah] comment: This term was made obsolete because 'drug' is not defined clearly. synonym: "abnormal cellular response to drug during vegetative growth" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2011-04-13T03:41:10Z [Term] id: FYPO:0000212 name: abnormal cellular response to heat def: "A cellular response phenotype observed in the vegetative growth phase of the life cycle in which the cellular response to heat is abnormal." [PomBase:mah] comment: Use this term if you have assayed the response to heat at the subcellular or molecular level. If you have assayed growth of cells exposed to heat in culture, use 'sensitive to heat' (FYPO:0000082) or 'resistance to heat' (FYPO:0002626). synonym: "abnormal cellular response to heat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal cellular response to heat during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001341 ! abnormal cellular response to stress during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0034605 ! cellular response to heat intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0034605 ! cellular response to heat relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:41:10Z [Term] id: FYPO:0000213 name: abnormal vesicle-mediated transport during vegetative growth def: "A transport phenotype observed in the vegetative growth phase of the life cycle in which vesicle-mediated transport is abnormal." [PomBase:mah] synonym: "abnormal vesicle-mediated transport during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001336 ! transport phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0001720 ! abnormal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0016192 ! vesicle-mediated transport intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0016192 ! vesicle-mediated transport relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:41:10Z [Term] id: FYPO:0000214 name: abnormal mitotic chromosome condensation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitotic chromosome condensation is abnormal." [PomBase:mah] synonym: "abnormal mitotic chromosome condensation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000159 ! abnormal chromosome condensation is_a: FYPO:0001346 ! DNA metabolism phenotype during vegetative growth is_a: FYPO:0001353 ! abnormal cellular component organization during vegetative growth is_a: FYPO:0001363 ! abnormal metabolic process during vegetative growth is_a: FYPO:0002737 ! abnormal mitotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0007076 ! mitotic chromosome condensation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0007076 ! mitotic chromosome condensation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:41:10Z [Term] id: FYPO:0000215 name: abnormal intracellular protein transport def: "A transport phenotype observed in the vegetative growth phase of the life cycle in which intracellular protein transport is abnormal." [PomBase:mah] synonym: "abnormal intracellular protein transport during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal intracellular protein transport during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000540 ! abnormal protein transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006886 ! intracellular protein transport intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006886 ! intracellular protein transport relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:41:10Z [Term] id: FYPO:0000216 name: abnormal negative regulation of mitotic DNA replication initiation def: "A regulation phenotype observed in the vegetative growth phase of the life cycle in which negative regulation of the initiation of mitotic DNA replication is abnormal. May result in re-replication of all or part of the genome." [PomBase:mah] synonym: "abnormal negative regulation of DNA replication initiation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal negative regulation of mitotic DNA replication initiation" EXACT [PomBase:mah] synonym: "abnormal negative regulation of mitotic DNA replication initiation during vegetative growth" EXACT [PomBase:mah] synonym: "DNA replication defects, endoreduplication" RELATED [PomBase:mah] synonym: "mitotic DNA re-replication" RELATED [PomBase:mah] synonym: "mitotic DNA rereplication" RELATED [PomBase:mah] is_a: FYPO:0001248 ! abnormal regulation of mitotic DNA replication initiation is_a: FYPO:0004757 ! abnormal negative regulation of DNA replication initiation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1903467 ! negative regulation of mitotic DNA replication initiation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1903467 ! negative regulation of mitotic DNA replication initiation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000217 name: abnormal DNA replication def: "A cellular process phenotype in which DNA replication is abnormal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "abnormal DNA-dependent DNA replication" EXACT [PomBase:mah] is_a: FYPO:0000293 ! DNA metabolism phenotype is_a: FYPO:0000860 ! abnormal metabolic process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0006261 ! DNA-dependent DNA replication intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0006261 ! DNA-dependent DNA replication relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-13T03:41:10Z [Term] id: FYPO:0000218 name: decreased Mre11 complex assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of Mre11 complex assembly is decreased." [PomBase:mah] synonym: "decreased Mre11 complex assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased Mre11 complex assembly during vegetative growth" EXACT [PomBase:mah] synonym: "MRN complex formation, reduced" EXACT [PomBase:mah] is_a: FYPO:0000447 ! abnormal protein complex assembly is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072685 ! Mre11 complex assembly relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072685 ! Mre11 complex assembly created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000219 name: increased protein oxidation during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of oxidation of one or more specific proteins, or of specific protein sites, is increased, resulting in the accumulation of proteins with oxidative modifications including carbonylated proteins." [PomBase:mah] synonym: "accumulation of carbonylated proteins during vegetative growth" RELATED [PomBase:mah] synonym: "increased level of disulfides during vegetative growth" RELATED [PomBase:al] synonym: "increased level of oxidised thiols in proteins during vegetative growth" RELATED [PomBase:al] synonym: "increased level of oxidized protein thiols during vegetative growth" RELATED [PomBase:mah] synonym: "increased protein oxidation during mitotic cell cycle during vegetative growth" RELATED [PomBase:mah] is_a: FYPO:0000547 ! increased protein modification during vegetative growth is_a: FYPO:0003863 ! increased protein oxidation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0018158 ! protein oxidation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0018158 ! protein oxidation created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000220 name: increased centromeric outer repeat transcript level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which RNAs transcribed from the centromere outer repeat region are present at greater levels than normal." [PMID:20211136, PomBase:mah] comment: This term encompasses both unprocessed RNA transcribed from the centromere outer repeat region and siRNAs derived by dicer-mediated processing of the primary transcripts. Use this term only for levels of RNA transcribed from endogenous centromere outer repeat sequences. For levels of RNA transcribed from an exogenous reporter gene placed in the outer repeat region, consider 'decreased chromatin silencing at centromere outer repeat region' (FYPO:0003412). synonym: "increased accumulation of centromeric outer repeat transcripts" RELATED [PomBase:mah] synonym: "increased accumulation of centromeric outer repeat transcripts during vegetative growth" RELATED [PomBase:mah] synonym: "increased accumulation of non-coding outer repeat transcripts" EXACT [PomBase:vw] synonym: "increased centromere outer repeat transcript level" EXACT [PomBase:mah] synonym: "increased centromeric outer repeat transcript level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased centromeric outer repeat transcript level during vegetative growth" EXACT [PomBase:mah] synonym: "increased centromeric outer repeat-derived transcript level" EXACT [PomBase:vw] synonym: "increased level of centromeric outer repeat transcripts" EXACT [PomBase:mah] is_a: FYPO:0000825 ! increased RNA level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards SO:0001905 ! regional_centromere_outer_repeat_transcript relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards SO:0001905 ! regional_centromere_outer_repeat_transcript created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000221 name: transcription regulation phenotype, adaptive response to loss of mtDNA def: "A transcription regulation phenotype observed in the vegetative growth phase of the life cycle in which the transcription of specific genes is regulated in response to the loss of mitochondrial DNA." [PMID:17868468, PomBase:mah] comment: This term was made obsolete because it was used only to map a legacy vocabulary term that described expression patterns captured by an expression profiling link. synonym: "adaptive expression responses" EXACT [PomBase:mah] synonym: "fission yeast transcription regulation phenotype, adaptive response to loss of mtDNA" EXACT [PomBase:mah] synonym: "transcription regulation phenotype, adaptive response to loss of mtDNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "transcription regulation phenotype, adaptive response to loss of mtDNA during vegetative growth" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000223 name: elongated multiseptate vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which cells are elongated and have more than one septum per cell." [PomBase:mah] synonym: "elongated multiseptate cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "elongated multiseptate cells during vegetative growth" EXACT [PomBase:mah] synonym: "long multiseptate cells" EXACT [PomBase:vw] is_a: FYPO:0004750 ! elongated septated vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000118 ! multiseptate vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000118 ! multiseptate vegetative cell created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000224 name: lemon-shaped cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a single cell grows in the form of a lemon. A lemon shape is defined mathematically as having a quadric surface in three dimensions obtained by rotating less than half of a circular arc about an axis passing through the endpoints of the arc." [http://mathworld.wolfram.com/Lemon.html, PomBase:mah] synonym: "cell morphology, lemon shaped" EXACT [PomBase:mah] synonym: "lemon-shaped cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "lemon-shaped cell during vegetative growth" EXACT [PomBase:mah] synonym: "lemon-shaped vegetative cell" EXACT [PomBase:mah] is_a: FYPO:0002196 ! abnormal vegetative cell shape is_a: PATO:0002345 ! lemon-shaped intersection_of: PATO:0002345 ! lemon-shaped intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000225 name: snowman-shaped spore def: "A cell morphology phenotype in which a spore assumes a snowman shape, having two connected parts, roughly spherical, of different sizes." [PomBase:mah] synonym: "cell morphology, snowman during sporulation" RELATED [PomBase:mah] synonym: "snowman during sporulation" RELATED [PomBase:mah] is_a: FYPO:0002467 ! abnormal spore shape is_a: PATO:0002346 ! snowman-shaped intersection_of: PATO:0002346 ! snowman-shaped intersection_of: exists_during GO:0030437 ! ascospore formation intersection_of: inheres_in CL:0000596 ! sexual spore relationship: exists_during GO:0030437 ! ascospore formation relationship: inheres_in CL:0000596 ! sexual spore created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000227 name: chromosome loss during mitotic chromosome segregation def: "A chromosome segregation phenotype observed in the vegetative growth phase of the life cycle in which one or more chromosome or minichromosome is not correctly segregated to either daughter cells during mitosis." [PMID:11809834, PMID:20211136, PomBase:mah] synonym: "chromosome loss during mitotic sister chromatid segregation" EXACT [PomBase:mah] synonym: "chromosome loss during segregation during vegetative growth" EXACT [PomBase:mah] synonym: "chromosome segregation defects, chromosome loss" EXACT [PomBase:mah] is_a: FYPO:0000141 ! abnormal mitotic sister chromatid segregation created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000228 name: lagging mitotic chromosomes def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which sister chromatids do not move towards the spindle poles at the same time during mitosis, but instead one or more chromosomes remain distant from the spindle pole after the bulk of the DNA has separated. Mitotic sister chromatid segregation may stop before completing separation of chromosomes, or may eventually be completed." [PMID:11809834, PMID:20211136, PomBase:mah] comment: Consider also annotating to 'unequal mitotic sister chromatid segregation' (FYPO:0003241) or one of its descendants, because chromosomes that lag at anaphase are often missegregated at telophase. synonym: "chromosome segregation defects, lagging mitotic chromosomes" EXACT [PomBase:mah] synonym: "lagging chromosomes during vegetative growth" EXACT [PomBase:mah] synonym: "lagging mitotic sister chromatids" EXACT [PomBase:mah] is_a: FYPO:0000670 ! abnormal mitotic sister chromatid separation is_a: FYPO:0002090 ! lagging chromosomes created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000229 name: septation following abnormal mitotic chromosome segregation alt_id: FYPO:0000322 alt_id: FYPO:0000323 def: "An inviable phenotype observed in the vegetative growth phase of the life cycle in which a cell undergoes septation despite abnormal mitotic chromosome segregation, and gives rise to inviable daughter cells." [PomBase:jh, PomBase:mah, PomBase:vw] synonym: "septation following abnormal chromosome segregation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "septation following abnormal mitotic chromosome segregation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000049 ! inviable cell is_a: FYPO:0000141 ! abnormal mitotic sister chromatid segregation is_a: FYPO:0004639 ! abnormal cellular physical quality phenotype during vegetative growth created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000230 name: abnormal actomyosin contractile ring actin filament organization def: "A cytokinesis phenotype observed in the vegetative growth phase of the life cycle in which the assembly and distribution of actin filament bundles does not occur normally, resulting in the formation of an abnormal actomyosin contractile ring in which actin is absent or mislocalized." [GO:2000689, PMID:19713940, PomBase:mah] synonym: "abnormal actomyosin contractile ring actin filament organisation" EXACT [PomBase:mah] synonym: "abnormal actomyosin contractile ring actin filament organization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal actomyosin contractile ring actin filament organization during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal cytokinetic contractile ring actin filament organization" EXACT [PomBase:vw] synonym: "abnormal mitotic contractile ring actin filament organization" EXACT [PomBase:vw] is_a: FYPO:0000032 ! abnormal cytokinesis is_a: FYPO:0000727 ! abnormal actin filament organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:2000689 ! actomyosin contractile ring assembly actin filament organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:2000689 ! actomyosin contractile ring assembly actin filament organization relationship: part_of FYPO:0000161 ! abnormal actomyosin contractile ring assembly relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000231 name: abnormal actomyosin contractile ring myosin filament organization def: "A cytokinesis phenotype observed in the vegetative growth phase of the life cycle in which myosin filaments are not localized normally within the actomyosin contractile ring." [GO:2000708, PMID:19713940, PomBase:mah] synonym: "abnormal actomyosin contractile ring myosin filament organisation" EXACT [PomBase:mah] synonym: "abnormal actomyosin contractile ring myosin filament organization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal actomyosin contractile ring myosin filament organization during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal cytokinetic contractile ring myosin filament organization" EXACT [PomBase:vw] synonym: "abnormal mitotic contractile ring myosin filament organization" EXACT [PomBase:vw] synonym: "cytokinesis defects, contractile ring myosin distribution, defective" RELATED [PomBase:mah] is_a: FYPO:0000032 ! abnormal cytokinesis is_a: FYPO:0000801 ! abnormal actin cytoskeleton organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:2000708 ! myosin filament organization involved in cytokinetic actomyosin contractile ring assembly intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:2000708 ! myosin filament organization involved in cytokinetic actomyosin contractile ring assembly relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000232 name: split actomyosin contractile ring def: "A cytokinesis phenotype observed in the vegetative growth phase of the life cycle in which the actomyosin contractile ring splits upon initiation of contraction during anaphase B, resulting in the formation of a primary ring that undergoes constriction and a secondary ring that does not constrict." [PMID:18272786, PomBase:mah] synonym: "abnormal contractile ring contraction with contractile ring splitting" RELATED [PomBase:mah] synonym: "actomyosin contractile ring splitting" RELATED [PomBase:mah] synonym: "actomyosin contractile ring splitting upon contraction" RELATED [PomBase:mah] synonym: "cytokinesis defects, splitting of the actinomyosin ring" RELATED [PomBase:mah] synonym: "split actomyosin contractile ring during mitotic cell cycle" RELATED [PomBase:mah] synonym: "split actomyosin contractile ring during vegetative growth" EXACT [PomBase:mah] synonym: "split cytokinetic contractile ring" EXACT [PomBase:vw] synonym: "split mitotic contractile ring" EXACT [PomBase:vw] is_a: FYPO:0003338 ! abnormal actomyosin contractile ring morphology is_a: PATO:0001786 ! split intersection_of: PATO:0001786 ! split intersection_of: exists_during GO:0000092 ! mitotic anaphase B intersection_of: inheres_in GO:0005826 ! actomyosin contractile ring relationship: exists_during GO:0000092 ! mitotic anaphase B relationship: inheres_in GO:0005826 ! actomyosin contractile ring created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000233 name: long cytoplasmic microtubules def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells form cytoplasmic microtubules that are longer than normal." [PomBase:mah] synonym: "elongated cytoplasmic microtubules" EXACT [PomBase:mah] synonym: "long cytoplasmic microtubules during mitotic cell cycle" RELATED [PomBase:mah] synonym: "long cytoplasmic microtubules during vegetative growth" EXACT [PomBase:mah] synonym: "microtubule organization defect, long cytoplasmic microtubules" EXACT [PomBase:mah] synonym: "microtubule organization defects, long cytoplasmic microtubules" EXACT [PomBase:mah] is_a: FYPO:0000055 ! long microtubules is_a: FYPO:0004088 ! abnormal cytoplasmic microtubules intersection_of: PATO:0000573 ! increased length intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005881 ! cytoplasmic microtubule relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005881 ! cytoplasmic microtubule created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000234 name: abnormal interphase microtubule nucleation def: "A microtubule cytoskeleton organization phenotype observed in the vegetative growth phase of the life cycle in which nucleation of microtubules from interphase microtubule organizing centers (iMTOCs) is abnormal." [PMID:19001497, PomBase:mah] synonym: "abnormal interphase microtubule nucleation by interphase microtubule organizing center" EXACT [PomBase:mah] synonym: "abnormal interphase microtubule nucleation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal interphase microtubule nucleation during vegetative growth" EXACT [PomBase:mah] synonym: "cytoskeletal defects, cytoplasmic microtubule nucleation defects, Non-SPB" RELATED [PomBase:mah] is_a: FYPO:0001350 ! abnormal microtubule cytoskeleton organization during vegetative growth is_a: FYPO:0002734 ! abnormal cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0051415 ! interphase microtubule nucleation by interphase microtubule organizing center intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0051415 ! interphase microtubule nucleation by interphase microtubule organizing center relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000235 name: abnormal regulation of translation in response to osmotic stress def: "A gene expression phenotype observed in the vegetative growth phase of the life cycle in which regulation of translation in response to osmotic stress is abnormal. Translation may be down-regulated to a greater extent than normal, and may not be restored to normal levels post-stress." [PMID:18065650, PomBase:mah] synonym: "abnormal regulation of translation in response to osmotic stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal regulation of translation in response to osmotic stress during vegetative growth" EXACT [PomBase:mah] synonym: "defective in recovery of translation after hyperosmotic shock" RELATED [PomBase:mah] is_a: FYPO:0001332 ! abnormal regulation of translation in response to stress during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0043557 ! regulation of translation in response to osmotic stress intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0043557 ! regulation of translation in response to osmotic stress relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000236 name: abnormal regulation of translation in response to oxidative stress def: "A gene expression phenotype observed in the vegetative growth phase of the life cycle in which regulation of translation in response to oxidative stress is abnormal. Translation may be down-regulated to a greater extent than normal, and may not be restored to normal levels post-stress." [PMID:18065650, PomBase:mah] synonym: "abnormal regulation of translation in response to oxidative stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal regulation of translation in response to oxidative stress during vegetative growth" EXACT [PomBase:mah] synonym: "defective in recovery of translation after oxidative stress" RELATED [PomBase:mah] is_a: FYPO:0001332 ! abnormal regulation of translation in response to stress during vegetative growth is_a: FYPO:0001340 ! abnormal cellular response to oxidative stress during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0043556 ! regulation of translation in response to oxidative stress intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0043556 ! regulation of translation in response to oxidative stress relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000237 name: abnormal regulation of translation in response to nitrogen starvation def: "A gene expression phenotype in which regulation of translation in response to nitrogen starvation is abnormal. Translation may be down-regulated to a greater extent than normal, and may not be restored to normal levels upon prolonged nitrogen starvation." [PMID:18065650, PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "abnormal regulation of translation in response to nitrogen depletion" EXACT [PomBase:vw] synonym: "abnormal regulation of translation in response to nitrogen deprivation" EXACT [PomBase:vw] synonym: "defective in recovery of translation during nitrogen starvation" RELATED [PomBase:mah] is_a: FYPO:0000152 ! abnormal cellular response to nitrogen starvation is_a: FYPO:0000263 ! abnormal regulation of translation in response to stress intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0070321 ! regulation of translation in response to nitrogen starvation intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0070321 ! regulation of translation in response to nitrogen starvation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000238 name: inviable cell upon G0 to G1 transition def: "A cell phenotype in which a cell fails to resume growth after several days in G0 phase. The inviable cells show some features characteristic of apoptosis, including loss of DNA." [PMID:19197239, PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "die in G0 with an apoptotic-like phenotype" EXACT [PomBase:mah] synonym: "essential upon G0 to G1 transition" RELATED [PomBase:mah] is_a: FYPO:0000049 ! inviable cell intersection_of: FYPO:0000049 ! inviable cell intersection_of: during GO:0045023 ! G0 to G1 transition relationship: during GO:0045023 ! G0 to G1 transition created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000239 name: expression of MBF target genes increased def: "A gene expression phenotype observed in the vegetative growth phase of the life cycle in which transcription of genes that are regulated by MBF (the MluI cell cycle box factor) is increased." [PomBase:mah] synonym: "expression of MBF target genes increased during mitotic cell cycle" RELATED [PomBase:mah] synonym: "expression of MBF target genes increased during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001333 ! gene expression regulation phenotype during vegetative growth created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000240 name: abnormal filament morphology def: "A cell population phenotype in which the size, shape, or structure of invasively growing filaments is abnormal." [PomBase:mah] synonym: "filament morphology aberrant" EXACT [PomBase:mah] is_a: FYPO:0000003 ! cell population phenotype is_a: FYPO:0001985 ! abnormal phenotype created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000241 name: genome stability defects def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which any process that affects the physical integrity, replication, or segregation of genomic DNA is abnormal. Encompasses effects on DNA metabolism, chromosome organization, the spindle assembly checkpoint, and any DNA integrity checkpoint." [PomBase:jh, PomBase:mah, PomBase:vw] comment: This term was made obsolete because it groups a number of somewhat related phenomena, but was not defined clearly or precisely. synonym: "genome stability defects during mitotic cell cycle" RELATED [PomBase:mah] synonym: "genome stability defects during vegetative growth" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000242 name: normal growth on ammonia nitrogen source def: "A vegetative cell population growth phenotype in which cells grow normally in a medium containing ammonia as the nitrogen source." [PomBase:mah] synonym: "growth defect, normal growth with ammonia nitrogen source" RELATED [PomBase:mah] synonym: "normal cell population growth on ammonia nitrogen source" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal vegetative cell population growth on ammonia nitrogen source" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0000047 ! normal cell population growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:16134 ! ammonia relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:16134 ! ammonia created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000243 name: normal growth on proline nitrogen source def: "A vegetative cell population growth phenotype in which cells grow normally in a medium containing L-proline as the nitrogen source." [PomBase:mah] synonym: "growth defect, normal growth with proline nitrogen source" RELATED [PomBase:mah] synonym: "normal cell population growth on proline nitrogen source" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal vegetative cell population growth on proline nitrogen source" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0000047 ! normal cell population growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:17203 ! L-proline relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:17203 ! L-proline created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000244 name: loss of viability upon nutrient depletion def: "A cell population phenotype in which a smaller than normal proportion of the population remains viable when cells are deprived of nutrients such as carbon or nitrogen." [PomBase:mah] comment: Use this term to annotate experiments in which a culture is grown under nutrient-depleted conditions, and then the number of cells viable enough to form a colony upon return to nutrient-replete conditions is measured and compared to wild type. Also consider 'sensitive to nitrogen starvation' (FYPO:0002124). synonym: "decreased viability upon nutrient depletion" EXACT [PomBase:mah] synonym: "growth defect, required during nutrient depletion" RELATED [PomBase:mah] synonym: "loss of cell population viability upon nutrient depletion" EXACT [PomBase:mah] synonym: "loss of viability upon nutrient starvation" EXACT [PomBase:al] synonym: "reduced viability upon nutrient depletion" EXACT [PomBase:mah] is_a: FYPO:0001985 ! abnormal phenotype is_a: FYPO:0002057 ! cell population viability created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000245 name: loss of viability in stationary phase def: "A cell population phenotype in which a smaller than normal proportion of the population remains viable after entering stationary phase." [PomBase:mah] comment: Use this term to annotate experiments in which a culture is grown to stationary phase, and then the number of cells viable enough to form a colony upon return to conditions supporting vegetative growth is measured and compared to wild type. synonym: "decreased viability in stationary phase" EXACT [PomBase:mah] synonym: "growth defect, required for stationary phase" RELATED [PomBase:mah] synonym: "loss of cell population viability in stationary phase" EXACT [PomBase:mah] synonym: "reduced viability in stationary phase" EXACT [PomBase:mah] is_a: FYPO:0001985 ! abnormal phenotype is_a: FYPO:0002057 ! cell population viability created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000246 name: growth auxotrophic for antioxidant def: "A cell population phenotype in which a cell population grows only in the presence of an antioxidant in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "antioxidant required for cell population growth" EXACT [PomBase:mah] synonym: "antioxidant required for growth" EXACT [PomBase:mah] synonym: "antioxidant required for vegetative cell growth" EXACT [PomBase:mah] synonym: "growth defect, requires antioxidant for growth" EXACT [PomBase:mah] is_a: FYPO:0000128 ! auxotrophy is_a: PATO:0000422 ! auxotrophic intersection_of: PATO:0000422 ! auxotrophic intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:22586 ! antioxidant relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:22586 ! antioxidant created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000249 name: decreased cell population growth on ammonia nitrogen source alt_id: FYPO:0000248 def: "A vegetative cell population phenotype in which cell growth is decreased relative to normal in a medium containing ammonia as the nitrogen source." [PomBase:mah] comment: Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "decreased growth on ammonia nitrogen source" BROAD [PomBase:mah] synonym: "decreased vegetative cell growth on ammonia nitrogen source" EXACT [PomBase:mah] synonym: "growth defect, slow growth in minimal media" RELATED [PomBase:mah] synonym: "growth defect, slow growth with ammonia nitrogen source" NARROW [PomBase:mah] synonym: "reduced cell growth on ammonia nitrogen source" EXACT [PomBase:mah] synonym: "slow cell growth in minimal medium" RELATED [PomBase:mah] synonym: "slow cell growth on ammonia nitrogen source" NARROW [PomBase:mah] is_a: FYPO:0001355 ! decreased vegetative cell population growth intersection_of: FYPO:0000046 ! decreased cell population growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:16134 ! ammonia relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:16134 ! ammonia created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000250 name: decreased cell population growth on proline nitrogen source def: "A vegetative cell population growth phenotype in which cell growth is decreased relative to normal in a medium containing L-proline as the nitrogen source." [PMID:24344203, PomBase:mah] comment: Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "decreased growth on proline nitrogen source" BROAD [PomBase:mah] synonym: "decreased vegetative cell growth on proline nitrogen source" EXACT [PomBase:mah] synonym: "growth defect, slow growth with proline nitrogen source" RELATED [PomBase:mah] synonym: "reduced cell growth on proline nitrogen source" RELATED [PomBase:mah] synonym: "slow cell growth on proline nitrogen source" NARROW [PomBase:mah] is_a: FYPO:0001355 ! decreased vegetative cell population growth intersection_of: FYPO:0000046 ! decreased cell population growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:17203 ! L-proline relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:17203 ! L-proline created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000251 name: decreased cell population growth on galactose carbon source def: "A vegetative cell population growth phenotype in which cell growth is decreased relative to normal in a medium containing galactose as the carbon source." [PomBase:mah] comment: Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "decreased growth on galactose carbon source" BROAD [PomBase:mah] synonym: "decreased vegetative cell growth on galactose carbon source" EXACT [PomBase:mah] synonym: "growth defects, growth inhibition in galactose-based medium" RELATED [PomBase:mah] synonym: "reduced cell growth on galactose carbon source" EXACT [PomBase:mah] synonym: "slow cell growth on galactose carbon source" NARROW [PomBase:mah] is_a: FYPO:0001355 ! decreased vegetative cell population growth intersection_of: FYPO:0000046 ! decreased cell population growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:12936 ! D-galactose relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:12936 ! D-galactose created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000252 name: increased spontaneous diploidization def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which heterothallic haploid cells spontaneously form cells with diploid DNA content at a higher frequency than normal." [PMID:19101542, PomBase:mah] synonym: "high-frequency diploidization in heterothallic strains" EXACT [PomBase:mah] synonym: "increased spontaneous diploidization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased spontaneous diploidization during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001320 ! vegetative cell phenotype is_a: FYPO:0003037 ! abnormal cell phenotype created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000253 name: increased HMG-CoA reductase activity def: "A molecular function phenotype in which the observed rate of hydroxymethylglutaryl-CoA reductase (NADPH) activity is increased." [PMID:19041767, PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0000689 ! abnormal oxidoreductase activity is_a: PATO:0000912 ! increased rate intersection_of: PATO:0000912 ! increased rate intersection_of: inheres_in GO:0004420 ! hydroxymethylglutaryl-CoA reductase (NADPH) activity relationship: inheres_in GO:0004420 ! hydroxymethylglutaryl-CoA reductase (NADPH) activity created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000254 name: increased protein processing def: "A cellular metabolism phenotype observed in the vegetative growth phase of the life cycle in which the observed occurrence of protein processing is increased." [PMID:19520858, PomBase:mah] synonym: "increased protein processing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein processing during vegetative growth" EXACT [PomBase:mah] synonym: "increased Sre1 cleavage" NARROW [PomBase:mah] is_a: FYPO:0001421 ! abnormal protein processing during vegetative growth is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0016485 ! protein processing relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0016485 ! protein processing created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000255 name: increased nuclear protein level during vegetative growth def: "A cell phenotype in which the amount of protein measured in the cell nucleus is higher than normal when the cell is in the vegetative growth phase of the life cycle. Total protein or a specific protein may be affected." [PMID:12896976, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased nuclear protein level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein level in nucleus during vegetative growth" EXACT [PomBase:mah] synonym: "localization defects, nuclear accumulation of Pap1 and Sty1" NARROW [PomBase:mah] synonym: "nuclear accumulation of Pap1 and Sty1" NARROW [PomBase:mah] synonym: "nuclear accumulation of protein" EXACT [PomBase:mah] synonym: "nuclear protein accumulation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: FYPO:0001327 ! increased protein level during vegetative growth is_a: FYPO:0002403 ! abnormal nucleus intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005634 ! nucleus intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005634 ! nucleus relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000256 name: mutator def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which mutations occur at a higher frequency than normal." [PomBase:mah] synonym: "mutator during mitotic cell cycle" RELATED [PomBase:mah] synonym: "mutator during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001320 ! vegetative cell phenotype is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in SO:0001059 ! sequence_alteration relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in SO:0001059 ! sequence_alteration created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000257 name: normal phenotype def: "A phenotype that shows no detectable differences from normal. In fission yeast, the characteristics of wild type cells of the sequenced strain (972 h-) or the isogenic h+ or h90 strains are regarded as normal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast normal phenotype" EXACT [PomBase:mah] synonym: "no obvious phenotype" EXACT [PomBase:mah] is_a: FYPO:0000001 ! phenotype is_a: PATO:0000001 ! quality intersection_of: PATO:0000001 ! quality intersection_of: inheres_in FYPO:0000001 ! phenotype intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in FYPO:0000001 ! phenotype relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000258 name: normal phenotype during exponential phase def: "A cell phenotype that shows no detectable differences from normal during exponential growth." [PomBase:mah] synonym: "fission yeast normal phenotype during exponential phase" EXACT [PomBase:mah] synonym: "no phenotype in exponential phase" EXACT [PomBase:mah] synonym: "normal phenotype during exponential phase during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal phenotype during exponential phase during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001312 ! normal vegetative phenotype created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000260 name: abnormal G1/S phase transcription def: "A gene expression phenotype in which regulation of transcription during the G1/S phase of the cell cycle is abnormal." [PomBase:mah] synonym: "abnormal G1/S phase transcription during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal regulation of transcription involved in G1/S phase of mitotic cell cycle" EXACT [PomBase:mah] synonym: "periodic cell-cycle expression, abolished" RELATED [PomBase:mah] is_a: FYPO:0001335 ! transcription regulation phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0002737 ! abnormal mitotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000083 ! regulation of transcription involved in G1/S transition of mitotic cell cycle intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000083 ! regulation of transcription involved in G1/S transition of mitotic cell cycle relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000261 name: pleiotropic effects def: "Multiple different phenotypes due to a single mutation." [PomBase:mah] comment: This term was made obsolete because genes, alleles, etc. can be annotated with multiple specific phenotype terms. synonym: "pleiotropic effects during vegetative growth" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000262 name: abnormal cellular response to reactive oxygen species during G0 phase def: "A cell phenotype in which cells do not respond normally to reactive oxygen species, resulting in accumulation of oxidative damage including DNA damage, during G0 phase." [PMID:19197239, PomBase:mah] synonym: "protects against physiological oxidative damage in G0" RELATED [PomBase:mah] is_a: FYPO:0000180 ! abnormal cellular response to oxidative stress intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0044838 ! cell quiescence intersection_of: inheres_in_part_of GO:0034614 ! cellular response to reactive oxygen species intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0044838 ! cell quiescence relationship: inheres_in_part_of GO:0034614 ! cellular response to reactive oxygen species relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000263 name: abnormal regulation of translation in response to stress def: "A gene expression phenotype in which regulation of translation in response to stress is abnormal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "protein synthesis after stress, defective" RELATED [PomBase:mah] is_a: FYPO:0000162 ! abnormal cellular response to stress is_a: FYPO:0000289 ! translation regulation phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0043555 ! regulation of translation in response to stress intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0043555 ! regulation of translation in response to stress relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000264 name: resistance to microtubule-destabilizing substance def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of a microtubule-destabilizing substance than normal." [PomBase:mah] synonym: "resistance to microtubule depolymerizing drugs" EXACT [PomBase:mah] synonym: "resistance to microtubule destabilising substance" EXACT [PomBase:mah] synonym: "resistance to microtubule-destabilizing substance during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to microtubule-destabilizing substance during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to microtubule-destabilizing substance" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:61951 ! microtubule-destabilising agent relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:61951 ! microtubule-destabilising agent created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000265 name: sensitive to DNA damage def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to DNA damage." [PomBase:mah] comment: Use this term if you have assayed growth of cells exposed to DNA damage in culture. If you have assayed the response to DNA damage at the subcellular or molecular level, consider annotating to 'abnormal cellular response to DNA damage stimulus' (FYPO:0000157). Also consider specific phenotype terms for sensitivity to substances or other stimuli that can damage DNA, e.g. 'sensitive to DNA damaging agents' (FYPO:0000266), 'sensitive to methyl methanesulfonate' (FYPO:0000089), 'sensitive to UV' (FYPO:0000268), etc. synonym: "hypersensitive to DNA damage" EXACT [PomBase:mah] synonym: "sensitive to DNA damage during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to DNA damage during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000304 ! sensitive to stress during vegetative growth created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000266 name: sensitive to DNA damaging agents def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to a genotoxin, any chemical compound that can act to induce direct or indirect DNA damage. Cells stop growing (and may die) at a concentration of a DNA damaging agent that allows wild type cells to grow." [CHEBI:50902, PomBase:mah] synonym: "hypersensitive to DNA damaging agents" EXACT [PomBase:mah] synonym: "sensitive to DNA damaging agents during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to DNA damaging agents during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:50902 ! genotoxin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:50902 ! genotoxin created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000267 name: sensitive to ionizing radiation during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to ionizing radiation." [PomBase:mah] synonym: "hypersensitive to ionizing radiation during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to gamma irradiation during vegetative growth" NARROW [PomBase:al] synonym: "sensitive to gamma radiation during vegetative growth" NARROW [PomBase:al] synonym: "sensitive to ionizing radiation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to IR during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000304 ! sensitive to stress during vegetative growth created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000268 name: sensitive to UV during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to ultraviolet light." [PomBase:mah] synonym: "hypersensitive to UV during vegetative growth" EXACT [PomBase:mah] synonym: "increased sensitivity to UV irradiation during vegetative growth" EXACT [PomBase:vw] synonym: "sensitive to ultraviolet light during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to UV during mitotic cell cycle" RELATED [PomBase:mah] synonym: "UV resistance: decreased during vegetative growth" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000304 ! sensitive to stress during vegetative growth is_a: FYPO:0002550 ! sensitive to UV created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000269 name: sensitive to microtubule depolymerizing drugs def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to a microtubule-destabilizing substance. Cells stop growing (and may die) at a concentration of a microtubule-depolymerizing drug that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to microtubule depolymerizing drugs" EXACT [PomBase:mah] synonym: "sensitive to microtubule depolymerizing drugs during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to microtubule depolymerizing drugs during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:61951 ! microtubule-destabilising agent relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:61951 ! microtubule-destabilising agent created_by: midori creation_date: 2011-04-19T02:59:38Z [Term] id: FYPO:0000270 name: sensitive to osmotic stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to osmotic stress." [PomBase:mah] comment: Use this term if you have assayed growth of cells exposed to osmotic stress in culture. If you have assayed the response to osmotic stress at the subcellular or molecular level, consider annotating to 'abnormal cellular response to osmotic stress' (FYPO:0000193). synonym: "hypersensitive to osmotic stress" EXACT [PomBase:mah] synonym: "osmotic stress resistance: decreased" EXACT [SGD:phenotype_annotation] synonym: "sensitive to osmotic stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to osmotic stress during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000304 ! sensitive to stress during vegetative growth created_by: midori creation_date: 2011-04-19T04:37:01Z [Term] id: FYPO:0000271 name: sensitive to salt stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to a salt stress." [PomBase:mah] synonym: "hypersensitive to salt stress" EXACT [PomBase:mah] synonym: "ionic stress resistance: decreased" EXACT [SGD:phenotype_annotation] synonym: "sensitive to salt stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to salt stress during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000270 ! sensitive to osmotic stress created_by: midori creation_date: 2011-04-19T04:37:01Z [Term] id: FYPO:0000272 name: abolished septum formation def: "A septation phenotype observed in the vegetative growth phase of the life cycle in which a cell fails to form a septum." [PMID:9649519, PomBase:mah] synonym: "abolished mitotic barrier septum assembly" EXACT [GO:0000917, PomBase:mah] synonym: "septum formation abolished" EXACT [PomBase:mah] synonym: "septum formation abolished during vegetative growth" EXACT [PomBase:mah] synonym: "septum formation: absent" EXACT [SGD:phenotype_annotation] synonym: "septum initiation defective" RELATED [PomBase:mah] is_a: FYPO:0000117 ! abnormal septation is_a: FYPO:0000417 ! abolished cytokinesis intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0000917 ! barrier septum assembly relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0000917 ! barrier septum assembly created_by: midori creation_date: 2011-04-19T04:37:01Z [Term] id: FYPO:0000273 name: centromeric outer repeat transcripts absent def: "An RNA metabolism phenotype observed in the vegetative growth phase of the life cycle in which RNAs transcribed from the centromere outer repeat region are absent." [PMID:20211136, PomBase:mah] comment: This term encompasses both unprocessed RNA transcribed from the centromere outer repeat region and siRNAs derived by dicer-mediated processing of the primary transcripts. Use this term only for levels of RNA transcribed from endogenous centromere outer repeat sequences. For levels of RNA transcribed from an exogenous reporter gene placed in the outer repeat region, consider 'abnormal chromatin silencing at centromere outer repeat region' (FYPO:0002346). synonym: "centromere outer repeat transcripts absent" EXACT [PomBase:mah] synonym: "centromeric outer repeat transcripts absent during mitotic cell cycle" RELATED [PomBase:mah] synonym: "centromeric outer repeat transcripts absent during vegetative growth" EXACT [PomBase:mah] synonym: "centromeric outer repeat-derived transcripts absent" EXACT [PomBase:vw] is_a: FYPO:0003094 ! decreased centromeric outer repeat transcript level is_a: FYPO:0003161 ! RNA absent from cell during vegetative growth intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards SO:0001905 ! regional_centromere_outer_repeat_transcript relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards SO:0001905 ! regional_centromere_outer_repeat_transcript created_by: midori creation_date: 2011-04-19T04:37:01Z [Term] id: FYPO:0000274 name: increased duration of mitotic M phase alt_id: FYPO:0000609 def: "A cell cycle phenotype in the duration of M phase of the mitotic cell cycle is longer than normal." [PomBase:mah] synonym: "delayed mitotic M phase progression" RELATED [PomBase:mah] synonym: "delayed mitotic M phase progression during vegetative growth" EXACT [PomBase:mah] synonym: "increased mitotic M phase duration" EXACT [PomBase:mah] synonym: "increased mitotic M phase duration during vegetative growth" EXACT [PomBase:mah] synonym: "mitotic cell cycle progression in M phase: delayed" EXACT [SGD:phenotype_annotation] synonym: "prolonged mitotic M phase" EXACT [PomBase:mah] synonym: "spindle checkpoint activated" RELATED [PomBase:mah] is_a: FYPO:0000607 ! abnormal mitotic M phase progression is_a: FYPO:0001069 ! increased duration of mitotic cell cycle phase intersection_of: PATO:0000498 ! increased duration intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000087 ! mitotic M phase relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_output FYPO:0000420 ! delayed cytokinesis relationship: inheres_in GO:0000087 ! mitotic M phase created_by: midori creation_date: 2011-04-19T04:37:01Z [Term] id: FYPO:0000275 name: spindle checkpoint required def: "A cell cycle phenotype in which cells are viable only if a spindle checkpoint functions normally." [PMID:15483052, PomBase:mah] comment: This term was made obsolete because it was used to represent two different phenotypes. is_obsolete: true consider: FYPO:0000029 consider: FYPO:0000324 consider: FYPO:0000333 created_by: midori creation_date: 2011-04-19T04:37:01Z [Term] id: FYPO:0000276 name: monopolar mitotic spindle def: "A physical cellular phenotype in which the mitotic spindle forms with microtubules emanating from only one pole." [PMID:11792803, PMID:9763447, PomBase:mah] comment: Also consider annotating to 'abnormal spindle pole body separation' (FYPO:0001733) or one of its children. synonym: "monopolar mitotic spindle during vegetative growth" EXACT [PomBase:mah] synonym: "spindle defects, monopolar mitotic spindle" EXACT [PomBase:mah] synonym: "spindle defects, monopolar spindle" EXACT [PomBase:mah] is_a: FYPO:0000338 ! abnormal mitotic spindle created_by: midori creation_date: 2011-04-19T04:37:01Z [Term] id: FYPO:0000278 name: decreased cell population growth following spore germination def: "A cell population phenotype in which cell population growth is decreased following spore germination, resulting in the formation of a smaller colony than normal in a given amount of time." [PomBase:mah] comment: Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "decreased growth following spore germination" BROAD [PomBase:mah] synonym: "reduced cell population growth following spore germination" EXACT [PomBase:mah] synonym: "slow cell population growth following spore germination" NARROW [PomBase:mah] synonym: "spores produced smaller colonies" RELATED [PomBase:mah] is_a: FYPO:0000046 ! decreased cell population growth intersection_of: FYPO:0000046 ! decreased cell population growth intersection_of: preceded_by GO:0009847 ! spore germination relationship: preceded_by GO:0009847 ! spore germination created_by: midori creation_date: 2011-04-19T04:37:01Z [Term] id: FYPO:0000279 name: formation of azygotic ascus upon sporulation def: "A sporulation phenotype in which azygotic asci form following conjugation and subsequent sporulation. Azygotic ascus formation occurs when meiosis takes place within a diploid cell rather than in a zygote produced by sporulation. Zygotes can resume vegetative growth and form colonies of diploid cells if returned to rich media before commitment to meiosis; under nitrogen starvation, diploid cells heterozygous for mating type will undergo azygotic meiosis. Azygotic asci have a characteristic linear morphology resembling that of a single vegetatively growing cell." [PMID:16169489, PMID:18780734, PMID:20404563, PomBase:mah] comment: This term was made obsolete because it was incorrectly defined. Although the description in the text definition is accurate, azygotic sporulation is not necessarily an abnormal occurrence. The term was also used incorrectly in annotations. synonym: "abnormal sporulation resulting in formation of azygotic asci" EXACT [PomBase:mah] synonym: "formation of azygotic asci upon sporulation" EXACT [PomBase:mah] synonym: "sporulation defects, azygotic asci" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2011-04-19T04:37:01Z [Term] id: FYPO:0000280 name: sterile alt_id: FYPO:0000638 def: "A cellular process phenotype in which conjugation does not occur." [PomBase:mah] synonym: "conjugation abolished" EXACT [PomBase:mah] synonym: "zygote formation abolished" RELATED [PomBase:mah] is_a: FYPO:0000031 ! abnormal conjugation is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0000747 ! conjugation with cellular fusion relationship: towards GO:0000747 ! conjugation with cellular fusion created_by: midori creation_date: 2011-04-19T04:37:01Z [Term] id: FYPO:0000281 name: small vacuoles present in greater numbers during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell contains more, but smaller, vacuoles than normal." [PomBase:mah] synonym: "fragmented vacuoles during vegetative growth" RELATED [PomBase:mah] synonym: "small vacuoles present in greater numbers during mitotic cell cycle" RELATED [PomBase:mah] synonym: "vacuole fusion defects" RELATED [PomBase:vw] synonym: "vacuole organization defects, fragmented vacuoles during vegetative growth" RELATED [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0002787 ! small vacuoles intersection_of: has_part FYPO:0002790 ! vacuoles present in greater numbers relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0002787 ! small vacuoles relationship: has_part FYPO:0002790 ! vacuoles present in greater numbers created_by: midori creation_date: 2011-04-19T04:37:01Z [Term] id: FYPO:0000282 name: viable cell at high temperature def: "A viability phenotype observed in the vegetative growth phase of the life cycle in which a cell is able to survive at a high temperature." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "cell viable at high temperature" EXACT [PomBase:mah] synonym: "viable cell at high temperature during mitotic cell cycle" RELATED [PomBase:mah] synonym: "viable cell at high temperature during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001491 ! viable vegetative cell intersection_of: FYPO:0000124 ! viable cell intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0001305 ! increased temperature relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0001305 ! increased temperature created_by: midori creation_date: 2011-04-19T04:37:01Z [Term] id: FYPO:0000283 name: mitotic chromosome fragmentation upon segregation def: "A chromosome segregation phenotype in which chromosomes are broken during mitotic chromosome segregation." [PomBase:mah] synonym: "chromosome fragmentation upon mitotic chromosome segregation" EXACT [PomBase:mah] synonym: "chromosome fragmentation upon segregation during mitosis" EXACT [PomBase:mah] synonym: "chromosome fragmentation upon segregation during vegetative growth" EXACT [PomBase:mah] synonym: "chromosome segregation defects, chromosome fragmentation" EXACT [PomBase:mah] synonym: "fragmented mitotic chromosomes upon segregation" EXACT [PomBase:mah] is_a: FYPO:0000141 ! abnormal mitotic sister chromatid segregation is_a: FYPO:0000848 ! abnormal chromosome morphology is_a: PATO:0001444 ! broken intersection_of: PATO:0001444 ! broken intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005694 ! chromosome relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005694 ! chromosome created_by: midori creation_date: 2011-04-19T04:37:01Z [Term] id: FYPO:0000284 name: large and small daughter nuclei def: "A mitosis phenotype observed in the vegetative growth phase of the life cycle in which the nucleus divides unequally to produce one daughter nucleus that is larger than the other." [PMID:8769419, PomBase:mah] comment: Consider also annotating to 'abnormal kinetochore organization' (FYPO:0000807). synonym: "large and small daughter nuclei during mitotic cell cycle" RELATED [PomBase:mah] synonym: "large and small daughter nuclei during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000062 ! abnormal nuclear morphology during vegetative growth relationship: output_of FYPO:0001270 ! complete but unequal mitotic sister chromatid segregation created_by: midori creation_date: 2011-04-19T04:37:01Z [Term] id: FYPO:0000286 name: sensitive to manganese depletion def: "A cell population phenotype observed in the vegetative growth phase of the life cycle in which a population of cells grow poorly in medium that has a low concentration of manganese (Mn2+)." [PMID:14723709, PomBase:mah] synonym: "hypersensitive to manganese depletion" EXACT [PomBase:mah] synonym: "sensitive to manganese depletion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to manganese depletion during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001356 ! abnormal vegetative cell population growth created_by: midori creation_date: 2011-04-20T01:42:21Z [Term] id: FYPO:0000287 name: abnormal subcellular component def: "A physical cellular phenotype in which the amount, distribution, or morphology of a cell part is abnormal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "abnormal subcellular component physical object quality" EXACT [PomBase:mah] synonym: "abnormal subcellular structure" RELATED [PomBase:mah] is_a: FYPO:0004638 ! abnormal cellular physical quality phenotype intersection_of: PATO:0001241 ! physical object quality intersection_of: inheres_in_part_of GO:0044464 ! cell part intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0044464 ! cell part relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-21T11:18:18Z [Term] id: FYPO:0000288 name: gene expression regulation phenotype def: "A regulation phenotype that affects the regulation of gene expression." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast gene expression regulation phenotype" EXACT [PomBase:mah] is_a: FYPO:0000142 ! gene expression phenotype is_a: FYPO:0000145 ! regulation phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: inheres_in_part_of GO:0010468 ! regulation of gene expression relationship: inheres_in_part_of GO:0010468 ! regulation of gene expression created_by: midori creation_date: 2011-04-21T02:22:36Z [Term] id: FYPO:0000289 name: translation regulation phenotype def: "A gene expression phenotype that affects the regulation of translation." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast translation regulation phenotype" EXACT [PomBase:mah] is_a: FYPO:0000288 ! gene expression regulation phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: inheres_in_part_of GO:0006417 ! regulation of translation relationship: inheres_in_part_of GO:0006417 ! regulation of translation created_by: midori creation_date: 2011-04-21T02:25:06Z [Term] id: FYPO:0000290 name: transcription phenotype during vegetative growth def: "A cellular process phenotype that affects DNA-dependent transcription." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast transcription phenotype" EXACT [PomBase:mah] synonym: "transcription phenotype during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000142 ! gene expression phenotype is_a: FYPO:0000294 ! RNA metabolism phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006351 ! transcription, DNA-templated relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006351 ! transcription, DNA-templated created_by: midori creation_date: 2011-04-21T02:31:20Z [Term] id: FYPO:0000291 name: translation phenotype def: "A cellular process phenotype that affects translation." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast translation phenotype" EXACT [PomBase:mah] synonym: "translation phenotype during mitotic cell cycle" RELATED [PomBase:mah] synonym: "translation phenotype during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000142 ! gene expression phenotype is_a: FYPO:0001348 ! cellular metabolism phenotype during vegetative growth intersection_of: FYPO:0000002 ! cell phenotype intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006412 ! translation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006412 ! translation created_by: midori creation_date: 2011-04-21T02:31:20Z [Term] id: FYPO:0000292 name: nucleic acid metabolism phenotype def: "A cellular process phenotype that affects any nucleic acid metabolic process." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast nucleic acid metabolism phenotype" EXACT [PomBase:mah] is_a: FYPO:0000140 ! cellular metabolism phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: inheres_in_part_of GO:0090304 ! nucleic acid metabolic process relationship: inheres_in_part_of GO:0090304 ! nucleic acid metabolic process created_by: midori creation_date: 2011-04-21T02:31:20Z [Term] id: FYPO:0000293 name: DNA metabolism phenotype def: "A cellular process phenotype that affects any DNA metabolic process." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast DNA metabolism phenotype" EXACT [PomBase:mah] is_a: FYPO:0000292 ! nucleic acid metabolism phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: inheres_in_part_of GO:0006259 ! DNA metabolic process relationship: inheres_in_part_of GO:0006259 ! DNA metabolic process created_by: midori creation_date: 2011-04-21T02:31:20Z [Term] id: FYPO:0000294 name: RNA metabolism phenotype def: "A cellular process phenotype that affects any RNA metabolic process." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast RNA metabolism phenotype" EXACT [PomBase:mah] synonym: "RNA metabolism phenotype during mitotic cell cycle" RELATED [PomBase:mah] synonym: "RNA metabolism phenotype during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001347 ! nucleic acid metabolism phenotype during vegetative growth intersection_of: FYPO:0000002 ! cell phenotype intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0016070 ! RNA metabolic process relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0016070 ! RNA metabolic process created_by: midori creation_date: 2011-04-21T02:31:20Z [Term] id: FYPO:0000295 name: cytoskeleton organization phenotype def: "A cellular process phenotype that affects cytoskeleton organization. Cytoskeleton organization results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GO:0007010, PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "cytoskeleton organisation phenotype" EXACT [PomBase:mah] synonym: "fission yeast cytoskeleton organization phenotype" EXACT [PomBase:mah] is_a: FYPO:0000334 ! cellular component organization phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: inheres_in_part_of GO:0007010 ! cytoskeleton organization relationship: inheres_in_part_of GO:0007010 ! cytoskeleton organization created_by: midori creation_date: 2011-04-21T02:31:20Z [Term] id: FYPO:0000296 name: actin cytoskeleton organization phenotype def: "A cellular process phenotype that affects the organization of the actin cytoskeleton. Actin cytoskeleton organization results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and associated proteins." [GO:0030036, PomBase:mah] comment: Consider annotating to 'abnormal actin cytoskeleton morphology' (FYPO:0000350), but note that an abnormal cytoskeleton organization process may, but does not necessarily, result in abnormal cytoskeleton morphology. synonym: "actin cytoskeleton organisation phenotype" EXACT [PomBase:mah] synonym: "actin cytoskeleton organization phenotype during mitotic cell cycle" RELATED [PomBase:mah] synonym: "actin cytoskeleton organization phenotype during vegetative growth" EXACT [PomBase:mah] synonym: "fission yeast actin cytoskeleton organization phenotype" EXACT [PomBase:mah] is_a: FYPO:0000295 ! cytoskeleton organization phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: inheres_in_part_of GO:0030036 ! actin cytoskeleton organization relationship: inheres_in_part_of GO:0030036 ! actin cytoskeleton organization created_by: midori creation_date: 2011-04-21T02:31:20Z [Term] id: FYPO:0000297 name: microtubule cytoskeleton organization phenotype def: "A cellular process phenotype that affects the organization of the microtubule cytoskeleton. Microtubule cytoskeleton organization results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and associated proteins." [GO:0000226, PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast microtubule cytoskeleton organization phenotype" EXACT [PomBase:mah] synonym: "microtubule cytoskeleton organisation phenotype" EXACT [PomBase:mah] is_a: FYPO:0000295 ! cytoskeleton organization phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: inheres_in_part_of GO:0000226 ! microtubule cytoskeleton organization relationship: inheres_in_part_of GO:0000226 ! microtubule cytoskeleton organization created_by: midori creation_date: 2011-04-21T02:31:20Z [Term] id: FYPO:0000298 name: cellular response phenotype def: "A cellular process phenotype that affects a response to a stimulus." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast cellular response phenotype" EXACT [PomBase:mah] is_a: FYPO:0000114 ! cellular process phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: inheres_in_part_of GO:0051716 ! cellular response to stimulus relationship: inheres_in_part_of GO:0051716 ! cellular response to stimulus created_by: midori creation_date: 2011-04-21T04:47:15Z [Term] id: FYPO:0000299 name: inviable microcolony def: "A cell population phenotype in which a cell undergoes one or a few rounds of cell division before cells die, resulting in the formation a colony that contains only a few inviable cells. Up to 6 rounds of cell division (generating 64 cells) may be observed, but 3 divisions or fewer is more typical." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype, with penetrance extensions where needed. synonym: "inviable microcolony formation" EXACT [PomBase:mah] synonym: "microcolony formation" BROAD [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2011-04-26T02:13:39Z [Term] id: FYPO:0000300 name: biological process phenotype def: "A phenotype that affects a biological process." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast biological process phenotype" EXACT [PomBase:mah] is_a: FYPO:0000001 ! phenotype intersection_of: FYPO:0000001 ! phenotype intersection_of: inheres_in_part_of GO:0008150 ! biological_process relationship: inheres_in_part_of GO:0008150 ! biological_process created_by: midori creation_date: 2011-04-26T02:25:13Z [Term] id: FYPO:0000301 name: mating phenotype def: "A biological process phenotype that affects conjugation." [PomBase:mah] synonym: "conjugation phenotype" EXACT [PomBase:mah] synonym: "fission yeast mating phenotype" EXACT [PomBase:mah] is_a: FYPO:0000300 ! biological process phenotype intersection_of: FYPO:0000001 ! phenotype intersection_of: inheres_in_part_of GO:0000747 ! conjugation with cellular fusion relationship: inheres_in_part_of GO:0000747 ! conjugation with cellular fusion created_by: midori creation_date: 2011-04-26T02:29:20Z [Term] id: FYPO:0000302 name: abnormal response to pheromone def: "A conjugation phenotype in which a cell's response to mating pheromone is abnormal." [PomBase:mah] synonym: "abnormal response to pheromone involved in conjugation with cellular fusion" EXACT [PomBase:mah] synonym: "defective response to pheromone" EXACT [PomBase:mah] is_a: FYPO:0000298 ! cellular response phenotype is_a: FYPO:0000628 ! abnormal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0000749 ! response to pheromone involved in conjugation with cellular fusion intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0000749 ! response to pheromone involved in conjugation with cellular fusion relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-26T02:36:20Z [Term] id: FYPO:0000303 name: decreased conjugation frequency def: "A conjugation phenotype in which conjugation occurs less frequently than normal." [PomBase:mah] comment: Note that this term refers specifically to conjugation, whereas experiments that measure mating efficiency often do so by counting zygotes plus asci, sometimes also including spores. For such experiments, we recommend using 'decreased mating efficiency' (FYPO:0000708). synonym: "decreased conjugation efficiency" EXACT [PomBase:mah] synonym: "decreased occurrence of conjugation" EXACT [PomBase:mah] synonym: "reduced conjugation efficiency" EXACT [PomBase:mah] synonym: "reduced conjugation frequency" EXACT [PomBase:mah] synonym: "reduced zygote formation" RELATED [PomBase:mah] is_a: FYPO:0000003 ! cell population phenotype created_by: midori creation_date: 2011-04-26T02:40:00Z [Term] id: FYPO:0000304 name: sensitive to stress during vegetative growth def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to a stress." [PomBase:mah] comment: Use this term if you have assayed growth of cells exposed to a stress in culture. If you have assayed the response to the stress at the subcellular or molecular level, consider annotating to 'abnormal cellular response to stress during vegetative growth' (FYPO:0001341). synonym: "hypersensitive to stress during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "stress resistance: decreased during vegetative growth" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001358 ! vegetative cell population growth phenotype is_a: FYPO:0002549 ! sensitive to stress created_by: midori creation_date: 2011-04-26T03:10:44Z [Term] id: FYPO:0000305 name: abnormal spore germination def: "A cellular process phenotype in which spore germination is abnormal." [PomBase:mah] is_a: FYPO:0000628 ! abnormal cellular process is_a: FYPO:0000679 ! developmental process phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0009847 ! spore germination intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0009847 ! spore germination relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-04-27T11:47:04Z [Term] id: FYPO:0000307 name: inviable small spore def: "A viability phenotype in which a spore is unable to survive under conditions in which wild type spores survive, and is smaller than normal. An inviable spore does not germinate." [PomBase:mah] synonym: "spore germination abolished, small spores" RELATED [PomBase:mah] is_a: FYPO:0000309 ! inviable spore with abnormal morphology intersection_of: FYPO:0000002 ! cell phenotype intersection_of: has_part FYPO:0000346 ! small spores intersection_of: has_part FYPO:0002151 ! inviable spore relationship: has_part FYPO:0000346 ! small spores relationship: has_part FYPO:0002151 ! inviable spore created_by: midori creation_date: 2011-04-27T11:47:04Z [Term] id: FYPO:0000309 name: inviable spore with abnormal morphology def: "A viability phenotype in which a spore is unable to survive under conditions in which wild type spores survive, and has an abnormal morphology (i.e. size, shape, or structure). An inviable spore does not germinate." [PomBase:mah] synonym: "spore germination abolished, abnormal spore morphology" RELATED [PomBase:mah] synonym: "spore germination abolished, misshapen spores" RELATED [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: has_part FYPO:0000348 ! abnormal spore morphology intersection_of: has_part FYPO:0002151 ! inviable spore relationship: has_part FYPO:0000348 ! abnormal spore morphology relationship: has_part FYPO:0002151 ! inviable spore created_by: midori creation_date: 2011-04-27T11:47:04Z [Term] id: FYPO:0000310 name: inviable after spore germination, without cell division, with normal germ tube morphology def: "A phenotype in which a spore germinates to produce a normal germ tube, but does not go on to form a viable dividing cell." [PomBase:mah] synonym: "essential; germinating spore, without cell division, with normal germ tube morphology" RELATED [PomBase:mah] synonym: "inviable after spore germination, undivided cell with normal germ tube morphology" EXACT [PomBase:mah] synonym: "inviable following spore germination, without cell division, with normal germ tube morphology" EXACT [PomBase:mah] synonym: "inviable germinated spore, without cell division, with normal germ tube morphology" EXACT [PomBase:mah] is_a: FYPO:0001991 ! inviable after spore germination, without cell division created_by: midori creation_date: 2011-04-27T11:47:04Z [Term] id: FYPO:0000311 name: inviable after spore germination with normal, unseptated germ tube morphology def: "A phenotype in which a spore germinates to produce a normal germ tube, but does not septate or go on to form a viable dividing cell." [PomBase:mah] synonym: "essential; germinating spore with normal, unseptated germ tube morphology" RELATED [PomBase:mah] synonym: "inviable following spore germination with normal, unseptated germ tube morphology" EXACT [PomBase:mah] synonym: "inviable germinated spore with normal, unseptated germ tube morphology" EXACT [PomBase:mah] is_a: FYPO:0000310 ! inviable after spore germination, without cell division, with normal germ tube morphology created_by: midori creation_date: 2011-04-27T11:47:04Z [Term] id: FYPO:0000312 name: inviable after spore germination with normal, septated germ tube morphology def: "A phenotype in which a spore germinates to produce a normal germ tube, and undergoes septation, but does not go on to form a viable dividing cell." [PomBase:mah] synonym: "essential; germinating spore with normal, septated germ tube morphology" RELATED [PomBase:mah] synonym: "inviable following spore germination with normal, septated germ tube morphology" EXACT [PomBase:mah] synonym: "inviable germinated spore with normal, septated germ tube morphology" EXACT [PomBase:mah] is_a: FYPO:0000310 ! inviable after spore germination, without cell division, with normal germ tube morphology created_by: midori creation_date: 2011-04-27T11:47:04Z [Term] id: FYPO:0000313 name: inviable after spore germination, without cell division, with abnormal germ tube morphology def: "A phenotype in which a spore germinates to produce a germ tube with abnormal morphology (i.e. size, shape, or structure), and does not go on to form a viable dividing cell." [PomBase:mah] synonym: "essential; germinating spore, without cell division with abnormal germ tube morphology" RELATED [PomBase:mah] synonym: "inviable after spore germination, undivided cell with abnormal germ tube morphology" EXACT [PomBase:mah] synonym: "inviable following spore germination, without cell division with abnormal germ tube morphology" EXACT [PomBase:mah] synonym: "inviable germinated spore, without cell division, with abnormal germ tube morphology" EXACT [PomBase:mah] is_a: FYPO:0001991 ! inviable after spore germination, without cell division created_by: midori creation_date: 2011-04-27T11:47:04Z [Term] id: FYPO:0000314 name: inviable after spore germination with elongated germ tube def: "A phenotype in which a spore germinates to produce an elongated germ tube, and does not go on to give rise to a viable cell population." [PomBase:mah] synonym: "essential; germinating spore with elongated germ tube" RELATED [PomBase:mah] synonym: "inviable after spore germination, elongated cell" EXACT [PomBase:mah] synonym: "inviable following spore germination with elongated germ tube" EXACT [PomBase:mah] synonym: "inviable germinated spore with elongated germ tube" EXACT [PomBase:mah] is_a: FYPO:0001490 ! inviable elongated vegetative cell is_a: FYPO:0002281 ! inviable after spore germination with abnormal germ tube morphology created_by: midori creation_date: 2011-04-27T11:47:04Z [Term] id: FYPO:0000315 name: inviable after spore germination, without cell division, with elongated, septated germ tube def: "A phenotype in which a spore germinates to produce an elongated germ tube, and undergoes septation, but does not go on to form a viable dividing cell." [PomBase:mah] synonym: "essential; germinating spore with elongated, septated germ tube" RELATED [PomBase:mah] synonym: "inviable after spore germination, without cell division, elongated, septated cell" EXACT [PomBase:mah] synonym: "inviable following spore germination with elongated, septated germ tube" EXACT [PomBase:mah] synonym: "inviable germinated spore, without cell division, with elongated, septated germ tube" EXACT [PomBase:mah] is_a: FYPO:0002379 ! inviable after spore germination, without cell division, with elongated germ tube created_by: midori creation_date: 2011-04-27T11:47:04Z [Term] id: FYPO:0000316 name: inviable after spore germination def: "A viability phenotype in which a spore germinates but fails to produce dividing cells that can survive under normal conditions." [PomBase:jh, PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "essential in germinating spore" RELATED [PomBase:mah] synonym: "inviable after spore germination" EXACT [PomBase:mah] synonym: "inviable germinated spore" EXACT [PomBase:mah] synonym: "inviable germinating spore" RELATED [PomBase:mah] is_a: FYPO:0001489 ! inviable vegetative cell intersection_of: FYPO:0000049 ! inviable cell intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: preceded_by GO:0009847 ! spore germination relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: preceded_by GO:0009847 ! spore germination created_by: midori creation_date: 2011-04-27T01:13:41Z [Term] id: FYPO:0000317 name: mixed population def: "A cell population phenotype in which a population contains cells with more than one phenotype, usually different morphologies." [PomBase:mah] comment: This term was made obsolete because a "mixed population" observation would be better represented as two or more separate phenotype annotations, each with penetrance specified. is_obsolete: true created_by: midori creation_date: 2011-04-27T01:32:52Z [Term] id: FYPO:0000318 name: inviable mixed population including long cells def: "A mixed population phenotype in which a microcolony forms, all cells in the population are inviable, some cells may divide, and some cells are longer than normal." [PomBase:jh, PomBase:mah] comment: This term was made obsolete because a "mixed population" observation would be better represented as two or more separate phenotype annotations, each with penetrance specified. synonym: "essential; mixed population including long cells" RELATED [PomBase:mah] synonym: "inviable microcolony including long cells" EXACT [PomBase:mah, PomBase:vw] synonym: "inviable mixed population including long vegetative cells" EXACT [PomBase:mah] synonym: "long low penetrance" RELATED [PomBase:jh, PomBase:vw] is_obsolete: true created_by: midori creation_date: 2011-04-27T04:18:16Z [Term] id: FYPO:0000319 name: inviable mixed population including spores and divided germinated spores def: "A mixed population phenotype in which all cells in a population are inviable, and the population includes a mixture of spores and germinated spores most of which go on to divide once or twice. Some germinated spores remain septated and do not complete cell division." [PomBase:jh, PomBase:mah] comment: This term was made obsolete because a "mixed population" observation would be better represented as two or more separate phenotype annotations, each with penetrance specified. synonym: "essential; mixed population including spores and divided germinated spores" RELATED [PomBase:mah] synonym: "put cut" RELATED [PomBase:jh] is_obsolete: true created_by: midori creation_date: 2011-04-27T04:20:40Z [Term] id: FYPO:0000320 name: inviable after spore germination, single cell division, normal cell morphology def: "A phenotype in which a spore germinates to produce a cell of normal morphology (i.e. size, shape, and structure) that undergoes a single round of cell division, and then dies." [PomBase:jh, PomBase:mah, PomBase:vw] synonym: "essential; germinating spore, single cell division, normal cell morphology" RELATED [PomBase:mah] synonym: "inviable following spore germination, single cell division, normal cell morphology" EXACT [PomBase:mah] synonym: "inviable germinated spore, single cell division, normal cell morphology" EXACT [PomBase:mah] is_a: FYPO:0002280 ! inviable after spore germination, single cell division created_by: midori creation_date: 2011-04-27T04:25:13Z [Term] id: FYPO:0000321 name: inviable mixed population including spores and undivided germinated spores def: "A mixed population phenotype in which all cells in a population are inviable, and the population includes a mixture of ungerminated spores and germinated spores that fail to divide." [PomBase:jh, PomBase:mah] comment: This term was made obsolete because a "mixed population" observation would be better represented as two or more separate phenotype annotations, each with penetrance specified. synonym: "essential; mixed population including spores and undivided germinated spores" RELATED [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2011-04-27T04:32:25Z [Term] id: FYPO:0000324 name: mitotic metaphase/anaphase transition delay alt_id: FYPO:0000393 def: "A cell cycle phenotype in which the onset of anaphase of the mitotic cell cycle begins later than normal." [PomBase:mah] synonym: "cell cycle passage through the metaphase-anaphase transition: delayed" EXACT [SGD:phenotype_annotation] synonym: "delayed cell cycle passage through mitotic metaphase-anaphase transition" EXACT [PomBase:mah] synonym: "mitotic cell cycle delay at metaphase/anaphase transition" EXACT [PomBase:mah] synonym: "mitotic metaphase/anaphase transition delay during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000409 ! delayed cell cycle phase transition is_a: FYPO:0002737 ! abnormal mitotic cell cycle process intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0007091 ! metaphase/anaphase transition of mitotic cell cycle relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_output FYPO:0000274 ! increased duration of mitotic M phase relationship: inheres_in GO:0007091 ! metaphase/anaphase transition of mitotic cell cycle created_by: midori creation_date: 2011-05-09T04:36:10Z [Term] id: FYPO:0000325 name: abnormal attachment of spindle microtubules to kinetochore def: "A cellular process phenotype in which the attachment of spindle microtubules to the kinetochore during a mitotic or meiotic nuclear division is abnormal." [PomBase:mah] is_a: FYPO:0001334 ! regulation phenotype during vegetative growth is_a: FYPO:0001350 ! abnormal microtubule cytoskeleton organization during vegetative growth is_a: FYPO:0002734 ! abnormal cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0008608 ! attachment of spindle microtubules to kinetochore intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0008608 ! attachment of spindle microtubules to kinetochore relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-05-11T01:50:15Z [Term] id: FYPO:0000326 name: abnormal sister chromatid biorientation def: "A cellular process phenotype in which the stable attachment of sister chromatids to microtubules emanating from opposite poles of the mitotic spindle during metaphase plate congression is abnormal." [PomBase:mah] comment: This term is more specific than 'abnormal attachment of mitotic spindle microtubules to kinetochore' (FYPO:0004213) because sister chromatid biorientation normally occurs only as part of metaphase plate congression, not during other stages of mitosis. FYPO:0004213 can be used for abnormal attachment observed at any time during mitosis. synonym: "abnormal sister chromatid biorientation during mitosis" EXACT [PomBase:mah] synonym: "abnormal sister chromatid biorientation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal sister chromatid biorientation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000325 ! abnormal attachment of spindle microtubules to kinetochore intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0031134 ! sister chromatid biorientation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0031134 ! sister chromatid biorientation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-05-11T01:51:05Z [Term] id: FYPO:0000327 name: resistance to trichostatin A def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of trichostatin A than normal." [PomBase:mah] synonym: "resistance to trichostatin A during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to trichostatin A during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to trichostatin A" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:46024 ! trichostatin A relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:46024 ! trichostatin A created_by: midori creation_date: 2011-05-11T02:55:53Z [Term] id: FYPO:0000328 name: abnormal protein metabolic process during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle that affects protein metabolism in the cell." [PomBase:mah] synonym: "abnormal cellular protein metabolic process during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal protein metabolic process during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001363 ! abnormal metabolic process during vegetative growth is_a: FYPO:0002274 ! abnormal protein metabolic process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0044267 ! cellular protein metabolic process intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0044267 ! cellular protein metabolic process relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-05-11T03:39:46Z [Term] id: FYPO:0000329 name: abnormal protein modification during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which protein modification is abnormal. All modifications may be affected, or only modifications of a certain type, or on specific proteins, or even specific sites within specific proteins." [PomBase:mah] synonym: "abnormal protein modification during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein/peptide modification during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000328 ! abnormal protein metabolic process during vegetative growth is_a: FYPO:0002494 ! abnormal protein modification intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006464 ! cellular protein modification process intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006464 ! cellular protein modification process relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-05-11T03:40:46Z [Term] id: FYPO:0000330 name: abnormal histone modification def: "A cellular process phenotype that affects histone modification." [PomBase:mah] synonym: "abnormal histone modification during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal histone modification during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000329 ! abnormal protein modification during vegetative growth is_a: FYPO:0001352 ! abnormal chromatin organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0016570 ! histone modification intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0016570 ! histone modification relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-05-11T03:41:32Z [Term] id: FYPO:0000331 name: decreased histone acetylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone acetylation occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased histone acetylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone acetylation during vegetative growth" EXACT [PomBase:mah] synonym: "reduced histone acetylation" EXACT [PomBase:mah] is_a: FYPO:0000456 ! abnormal histone acetylation is_a: FYPO:0002394 ! decreased protein acetylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0016573 ! histone acetylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0016573 ! histone acetylation created_by: midori creation_date: 2011-05-11T03:42:20Z [Term] id: FYPO:0000332 name: increased histone acetylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone acetylation occurs to a greater extent than normal." [PomBase:mah] synonym: "increased histone acetylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone acetylation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000456 ! abnormal histone acetylation is_a: FYPO:0004487 ! increased protein acetylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0016573 ! histone acetylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0016573 ! histone acetylation created_by: midori creation_date: 2011-05-11T03:43:21Z [Term] id: FYPO:0000333 name: mitotic G1/S transition delay alt_id: FYPO:0000396 alt_id: FYPO:0000480 alt_id: FYPO:0000543 def: "A cell cycle phenotype in which the G1/S transition of the mitotic cell cycle begins later than normal. The duration of G1 phase is thus longer than normal." [PomBase:mah] comment: A G1/S delay may indicate that a checkpoint, such as the cell size checkpoint or the G1/S DNA damage checkpoint, is activated. Checkpoint activation can be tested using checkpoint kinase mutants. synonym: "cell cycle progression through the G1/S phase transition: delayed" EXACT [SGD:phenotype_annotation] synonym: "delayed cell cycle progression through mitotic G1/S phase transition" EXACT [PomBase:mah] synonym: "delayed mitotic G1 phase progression" RELATED [PomBase:mah] synonym: "increased duration of mitotic G1 phase" RELATED [PomBase:mah] synonym: "increased duration of mitotic G1 phase during vegetative growth" RELATED [PomBase:mah] synonym: "increased duration of mitotic G1 phase progression" RELATED [PomBase:mah] synonym: "mitotic cell cycle delay at G1/S transition" EXACT [PomBase:mah] synonym: "mitotic cell cycle delay in G1" RELATED [PomBase:mah] synonym: "mitotic cell cycle progression in G1 phase: delayed" RELATED [SGD:phenotype_annotation] synonym: "mitotic cell cycle progression in G1 phase: increased duration" RELATED [SGD:phenotype_annotation] synonym: "mitotic G1/S transition delay during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000394 ! abnormal mitotic G1/S phase transition is_a: FYPO:0000409 ! delayed cell cycle phase transition is_a: FYPO:0000602 ! abnormal mitotic G1 phase progression is_a: FYPO:0001069 ! increased duration of mitotic cell cycle phase intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000082 ! G1/S transition of mitotic cell cycle relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000082 ! G1/S transition of mitotic cell cycle created_by: midori creation_date: 2011-05-11T04:08:59Z [Term] id: FYPO:0000334 name: cellular component organization phenotype def: "A phenotype that affects a process of cellular component organization, i.e. the assembly, arrangement of constituent parts, or disassembly of a cellular component, that occurs at the cellular level." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "cellular component organisation phenotype" EXACT [PomBase:mah] synonym: "cellular component organization phenotype at cellular level" EXACT [PomBase:mah] synonym: "fission yeast cellular component organization phenotype" EXACT [PomBase:mah] is_a: FYPO:0000114 ! cellular process phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: inheres_in_part_of GO:0016043 ! cellular component organization relationship: inheres_in_part_of GO:0016043 ! cellular component organization created_by: midori creation_date: 2011-06-03T11:55:29Z [Term] id: FYPO:0000335 name: abnormal cellular component organization def: "A cellular process phenotype in which any process of cellular component organization at the cellular level is abnormal." [GO:0016043, PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "abnormal cellular component organisation" EXACT [PomBase:mah] synonym: "abnormal cellular component organization at cellular level" EXACT [PomBase:mah] is_a: FYPO:0000334 ! cellular component organization phenotype is_a: FYPO:0000628 ! abnormal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0016043 ! cellular component organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0016043 ! cellular component organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-06-03T11:57:14Z [Term] id: FYPO:0000336 name: abnormal cellular component assembly def: "A cellular process phenotype in which any process of cellular component assembly at the cellular level is abnormal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "abnormal cellular component assembly at cellular level" EXACT [PomBase:mah] is_a: FYPO:0000335 ! abnormal cellular component organization intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0022607 ! cellular component assembly intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0022607 ! cellular component assembly relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-06-03T12:00:35Z [Term] id: FYPO:0000337 name: abnormal mitosis def: "A cellular process phenotype in which mitosis is abnormal." [PomBase:mah] synonym: "abnormal mitosis during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal mitotic nuclear division" EXACT [GO:0007067] synonym: "abnormal nuclear division during mitotic cell cycle" EXACT [PomBase:mah] is_a: FYPO:0000186 ! abnormal cell division is_a: FYPO:0001353 ! abnormal cellular component organization during vegetative growth is_a: FYPO:0002737 ! abnormal mitotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0007067 ! mitotic nuclear division intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0007067 ! mitotic nuclear division relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-06-03T12:29:47Z [Term] id: FYPO:0000338 name: abnormal mitotic spindle alt_id: FYPO:0000277 def: "A physical cellular phenotype in which the position or morphology of the mitotic spindle is abnormal." [PomBase:mah] synonym: "abnormal mitotic spindle during vegetative growth" EXACT [PomBase:mah] synonym: "mitotic spindle defects" EXACT [PomBase:mah] synonym: "spindle polarity defects" RELATED [PomBase:mah] is_a: FYPO:0000120 ! abnormal spindle is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth intersection_of: PATO:0001241 ! physical object quality intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072686 ! mitotic spindle intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072686 ! mitotic spindle relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-06-03T01:43:41Z [Term] id: FYPO:0000339 name: mislocalized septum during vegetative growth def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which a cell has a septum in an abnormal location. The normal location is at the midpoint of the long axis of the cell." [PomBase:mah] comment: Note that the location of the septum is determined by the location of the contractile ring, which in turn is determined by the location of the cell division site, so an abnormality in cell division site determination can be inferred from this phenotype. Consider also annotating to 'mislocalized actomyosin contractile ring' (FYPO:0001369) because if the contractile ring forms in an abnormal location, the septum will also do so. synonym: "abnormal septum localization during vegetative growth" RELATED [PomBase:mah] synonym: "abnormal septum location during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal septum position during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal septum positioning during vegetative growth" RELATED [PomBase:mah] synonym: "asymmetric septum during vegetative growth" EXACT [PomBase:mah] synonym: "asymmetrically located septum during vegetative growth" EXACT [PomBase:mah] synonym: "mislocalised septum during vegetative growth" EXACT [PomBase:mah] synonym: "mislocalized septum during mitotic cell cycle" RELATED [PomBase:mah] synonym: "mislocalized septum during vegetative growth" EXACT [PomBase:mah] synonym: "misplaced septum during vegetative growth" EXACT [PomBase:vw] is_a: FYPO:0002455 ! abnormal septum during vegetative growth is_a: FYPO:0004293 ! mislocalized septum intersection_of: PATO:0000628 ! mislocalised intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000935 ! barrier septum relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000935 ! barrier septum created_by: midori creation_date: 2011-06-13T02:57:21Z [Term] id: FYPO:0000340 name: haploinsufficient def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a single functional copy of a gene does not provide sufficient normal function in a diploid cell." [PomBase:mah] synonym: "haploinsufficient during mitotic cell cycle" RELATED [PomBase:mah] synonym: "haploinsufficient during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001320 ! vegetative cell phenotype is_a: FYPO:0003037 ! abnormal cell phenotype created_by: midori creation_date: 2011-06-13T04:23:38Z [Term] id: FYPO:0000341 name: haplosufficient def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a single functional copy of a gene provides sufficient normal function in a diploid cell." [PomBase:mah] synonym: "haplosufficient during mitotic cell cycle" RELATED [PomBase:mah] synonym: "haplosufficient during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001320 ! vegetative cell phenotype is_a: FYPO:0003037 ! abnormal cell phenotype created_by: midori creation_date: 2011-06-13T04:25:07Z [Term] id: FYPO:0000342 name: decreased cellular respiration def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of cellular respiration is decreased." [PomBase:mah] synonym: "decreased cellular respiration during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular respiration during vegetative growth" EXACT [PomBase:mah] synonym: "decreased respiration" BROAD [PomBase:mah] synonym: "decreased respiratory metabolism" EXACT [PomBase:mah] synonym: "reduced cellular respiration" EXACT [PomBase:mah] synonym: "respiratory metabolism: decreased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000078 ! abnormal cellular respiration is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0045333 ! cellular respiration relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0045333 ! cellular respiration created_by: midori creation_date: 2011-06-14T04:25:19Z [Term] id: FYPO:0000343 name: increased hydrogen sulfide biosynthesis def: "A cellular metabolism phenotype observed in the vegetative growth phase of the life cycle in which the biosynthesis of hydrogen sulfide is increased." [PomBase:mah] synonym: "increased H2S biosynthesis " EXACT [PomBase:mah] synonym: "increased hydrogen sulfide biosynthesis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased hydrogen sulfide biosynthesis during vegetative growth" EXACT [PomBase:mah] synonym: "increased hydrogen sulphide biosynthesis" EXACT [PomBase:mah] is_a: FYPO:0001348 ! cellular metabolism phenotype during vegetative growth is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0070814 ! hydrogen sulfide biosynthetic process relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_output FYPO:0001413 ! increased cellular sulfide level relationship: inheres_in GO:0070814 ! hydrogen sulfide biosynthetic process created_by: midori creation_date: 2011-06-14T04:44:26Z [Term] id: FYPO:0000344 name: enlarged nucleus during vegetative growth def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the nucleus is larger than normal." [PomBase:mah] synonym: "enlarged nuclei during vegetative growth" EXACT [PomBase:vw] synonym: "enlarged nucleus during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000062 ! abnormal nuclear morphology during vegetative growth is_a: FYPO:0002255 ! enlarged nucleus intersection_of: PATO:0000586 ! increased size intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005634 ! nucleus relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005634 ! nucleus created_by: midori creation_date: 2011-06-15T03:45:06Z [Term] id: FYPO:0000345 name: abnormal protein export from nucleus def: "A transport phenotype observed in the vegetative growth phase of the life cycle in which the export of protein from the nucleus is abnormal. Export of all proteins or a specific protein may be affected." [PomBase:mah] comment: Encompasses both export of proteins normally retained in the nucleus and nuclear retention of normally exported proteins. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein export from nucleus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein export from nucleus during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000215 ! abnormal intracellular protein transport is_a: FYPO:0000506 ! abnormal nuclear export intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006611 ! protein export from nucleus intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006611 ! protein export from nucleus relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-06-15T05:11:00Z [Term] id: FYPO:0000346 name: small spores def: "A cell morphology phenotype in which spores have an abnormally low volume." [PomBase:mah] is_a: FYPO:0000023 ! small cell is_a: FYPO:0000348 ! abnormal spore morphology intersection_of: PATO:0000596 ! decreased volume intersection_of: inheres_in CL:0000596 ! sexual spore relationship: inheres_in CL:0000596 ! sexual spore created_by: midori creation_date: 2011-07-07T03:26:17Z [Term] id: FYPO:0000347 name: swollen spore def: "A cell morphology phenotype in which a spore has a larger volume than normal. In a swollen cell, both length and diameter are greater than normal, although the cell is only considered elongated if the length:width ratio is also greater than normal." [PomBase:mah] synonym: "enlarged spore" RELATED [PomBase:mah] synonym: "increased spore size" RELATED [PomBase:vw] synonym: "increased spore volume" EXACT [PomBase:mah] synonym: "large spore" RELATED [PomBase:vw] is_a: FYPO:0000025 ! swollen cell is_a: FYPO:0000348 ! abnormal spore morphology intersection_of: PATO:0000595 ! increased volume intersection_of: inheres_in CL:0000596 ! sexual spore relationship: inheres_in CL:0000596 ! sexual spore created_by: midori creation_date: 2011-07-07T03:34:09Z [Term] id: FYPO:0000348 name: abnormal spore morphology def: "A cell phenotype characterized by altered spore morphology, i.e. the size, shape, or structure of the spore is abnormal." [PomBase:mah] is_a: FYPO:0000005 ! abnormal cell morphology intersection_of: PATO:0000051 ! morphology intersection_of: inheres_in CL:0000596 ! sexual spore intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in CL:0000596 ! sexual spore relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-07-07T03:35:26Z [Term] id: FYPO:0000349 name: abnormal Golgi morphology def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of the Golgi apparatus is abnormal." [PomBase:mah] comment: Note that an abnormal Golgi organization process may, but does not necessarily, result in abnormal Golgi morphology. synonym: "abnormal Golgi morphology during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal Golgi morphology during vegetative growth" EXACT [PomBase:mah] synonym: "Golgi morphology: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000353 ! abnormal endomembrane system morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005794 ! Golgi apparatus intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005794 ! Golgi apparatus relationship: output_of FYPO:0000806 ! abnormal Golgi organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-07-14T05:04:23Z [Term] id: FYPO:0000350 name: abnormal actin cytoskeleton morphology during vegetative growth def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of the actin cytoskeleton is abnormal." [PomBase:mah] comment: Note that an abnormal actin cytoskeleton organization process may, but does not necessarily, result in abnormal actin cytoskeleton morphology. synonym: "abnormal actin cytoskeleton morphology during mitotic cell cycle" RELATED [PomBase:mah] synonym: "actin cytoskeleton morphology: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000352 ! abnormal cytoskeleton morphology during vegetative growth is_a: FYPO:0002398 ! abnormal actin cytoskeleton during vegetative growth intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0015629 ! actin cytoskeleton intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0015629 ! actin cytoskeleton relationship: output_of FYPO:0000801 ! abnormal actin cytoskeleton organization during vegetative growth relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-07-14T05:04:23Z [Term] id: FYPO:0000351 name: abnormal cell wall morphology during vegetative growth def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of the fungal-type cell wall is abnormal." [PomBase:mah] synonym: "abnormal cell wall morphology during mitotic cell cycle" RELATED [PomBase:mah] synonym: "cell wall morphology: abnormal during vegetative growth" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000027 ! abnormal cell wall during vegetative growth is_a: FYPO:0002947 ! abnormal cell wall morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0009277 ! fungal-type cell wall intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0009277 ! fungal-type cell wall relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-07-14T05:04:23Z [Term] id: FYPO:0000352 name: abnormal cytoskeleton morphology during vegetative growth def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of the cytoskeleton is abnormal." [PomBase:mah] comment: Note that an abnormal cytoskeleton organization process may, but does not necessarily, result in abnormal cytoskeleton morphology. synonym: "abnormal cytoskeleton morphology during mitotic cell cycle" RELATED [PomBase:mah] synonym: "cytoskeleton morphology: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: FYPO:0003063 ! abnormal cytoskeleton morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005856 ! cytoskeleton intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005856 ! cytoskeleton relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-07-14T05:04:23Z [Term] id: FYPO:0000353 name: abnormal endomembrane system morphology def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of all or part of the endomembrane system is abnormal." [PomBase:mah] comment: Note that an abnormal endomembrane system organization process may, but does not necessarily, result in abnormal endomembrane system morphology. synonym: "abnormal endomembrane system morphology during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal endomembrane system morphology during vegetative growth" EXACT [PomBase:mah] synonym: "endomembrane system morphology: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0002404 ! abnormal endomembrane system is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0012505 ! endomembrane system intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0012505 ! endomembrane system relationship: output_of FYPO:0000804 ! abnormal endomembrane system organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-07-14T05:04:23Z [Term] id: FYPO:0000354 name: abnormal endoplasmic reticulum morphology def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of the endoplasmic reticulum is abnormal." [PomBase:mah] comment: Note that an abnormal endoplasmic reticulum organization process may, but does not necessarily, result in abnormal endoplasmic reticulum morphology. synonym: "abnormal endoplasmic reticulum morphology during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal endoplasmic reticulum morphology during vegetative growth" EXACT [PomBase:mah] synonym: "endoplasmic reticulum morphology: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000353 ! abnormal endomembrane system morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005783 ! endoplasmic reticulum intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005783 ! endoplasmic reticulum relationship: output_of FYPO:0000805 ! abnormal endoplasmic reticulum organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-07-14T05:04:23Z [Term] id: FYPO:0000355 name: normal endoplasmic reticulum morphology def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of the endoplasmic reticulum is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "endoplasmic reticulum morphology: normal" EXACT [SGD:phenotype_annotation] synonym: "normal endoplasmic reticulum morphology during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal endoplasmic reticulum morphology during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001313 ! normal subcellular component during vegetative growth is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005783 ! endoplasmic reticulum intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005783 ! endoplasmic reticulum relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-07-14T05:04:23Z [Term] id: FYPO:0000356 name: abnormal lipid particle morphology def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of lipid particles is abnormal." [PomBase:mah] comment: Note that an abnormal lipid particle organization process may, but does not necessarily, result in abnormal lipid particle morphology. synonym: "abnormal lipid droplet morphology" EXACT [GO:0005811] synonym: "abnormal lipid particle morphology during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal lipid particle morphology during vegetative growth" EXACT [PomBase:mah] synonym: "lipid particle morphology: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005811 ! lipid particle intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005811 ! lipid particle relationship: output_of FYPO:0000808 ! abnormal lipid particle organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-07-14T05:04:23Z [Term] id: FYPO:0000357 name: abnormal shmoo morphology def: "A physical cellular phenotype in which the size, shape, or structure of the mating projection is abnormal." [PomBase:mah] synonym: "abnormal conjugation tube morphology" EXACT [PomBase:mah] synonym: "abnormal mating projection morphology" EXACT [PomBase:mah] synonym: "mating projection morphology: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000287 ! abnormal subcellular component is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: inheres_in GO:0005937 ! mating projection intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0005937 ! mating projection relationship: output_of FYPO:0000568 ! abnormal shmoo formation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-07-14T05:04:23Z [Term] id: FYPO:0000358 name: mating projection absent def: "A physical cellular phenotype in which cells do not form mating projections." [PomBase:mah] synonym: "absent mating projection morphology" EXACT [PomBase:mah] synonym: "mating projection morphology: absent" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001126 ! abnormal cell shape is_a: PATO:0002000 ! lacks all parts of type intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards GO:0005937 ! mating projection relationship: inheres_in CL:0000000 ! cell relationship: towards GO:0005937 ! mating projection created_by: midori creation_date: 2011-07-14T05:04:23Z [Term] id: FYPO:0000359 name: abnormal mitochondrial morphology def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of the mitochondrion is abnormal." [PomBase:mah] comment: Note that an abnormal mitochondrion organization process may, but does not necessarily, result in abnormal mitochondrial morphology. synonym: "abnormal mitochondrial morphology during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal mitochondrial morphology during vegetative growth" EXACT [PomBase:mah] synonym: "mitochondrial morphology: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005739 ! mitochondrion intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005739 ! mitochondrion relationship: output_of FYPO:0000809 ! abnormal mitochondrion organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-07-14T05:04:23Z [Term] id: FYPO:0000360 name: abnormal RNA localization during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which RNA localization is abnormal." [PomBase:mah] synonym: "abnormal RNA localisation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal RNA localization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "RNA localization: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001337 ! localization phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0003057 ! abnormal RNA localization intersection_of: PATO:0000001 ! quality intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006403 ! RNA localization intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006403 ! RNA localization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-07-14T06:06:09Z [Term] id: FYPO:0000361 name: abnormal nucleolar morphology def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of the nucleolus is abnormal." [PomBase:mah] comment: Note that an abnormal nucleolus organization process may, but does not necessarily, result in abnormal nucleolar morphology. synonym: "abnormal nucleolar morphology during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal nucleolar morphology during vegetative growth" EXACT [PomBase:mah] synonym: "nucleolar morphology: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005730 ! nucleolus intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005730 ! nucleolus relationship: output_of FYPO:0000814 ! abnormal nucleolus organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-07-14T05:04:23Z [Term] id: FYPO:0000362 name: abnormal peroxisomal morphology def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of the peroxisome is abnormal." [PomBase:mah] comment: Note that an abnormal peroxisome organization process may, but does not necessarily, result in abnormal peroxisome morphology. synonym: "abnormal peroxisomal morphology during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal peroxisomal morphology during vegetative growth" EXACT [PomBase:mah] synonym: "peroxisomal morphology: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005777 ! peroxisome intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005777 ! peroxisome relationship: output_of FYPO:0000811 ! abnormal peroxisome organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-07-14T05:04:23Z [Term] id: FYPO:0000363 name: peroxisomes absent def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells do not contain peroxisomes." [PomBase:mah] synonym: "absent peroxisomal morphology" EXACT [PomBase:mah] synonym: "peroxisomal morphology: absent" EXACT [SGD:phenotype_annotation] synonym: "peroxisomes absent during mitotic cell cycle" RELATED [PomBase:mah] synonym: "peroxisomes absent during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: PATO:0002000 ! lacks all parts of type intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards GO:0005777 ! peroxisome relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards GO:0005777 ! peroxisome created_by: midori creation_date: 2011-07-14T05:04:23Z [Term] id: FYPO:0000364 name: abnormal plasma membrane morphology def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of the plasma membrane is abnormal." [PomBase:mah] comment: Note that an abnormal plasma membrane organization process may, but does not necessarily, result in abnormal plasma membrane morphology. synonym: "abnormal plasma membrane morphology during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal plasma membrane morphology during vegetative growth" EXACT [PomBase:mah] synonym: "plasma membrane morphology: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0003278 ! abnormal plasma membrane is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005886 ! plasma membrane intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005886 ! plasma membrane relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-07-14T05:04:23Z [Term] id: FYPO:0000365 name: small nucleus def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the nucleus is smaller than normal." [PomBase:mah] synonym: "size of nucleus: decreased" EXACT [SGD:phenotype_annotation] synonym: "small nuclei" EXACT [PomBase:vw] synonym: "small nucleus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "small nucleus during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000062 ! abnormal nuclear morphology during vegetative growth is_a: PATO:0000587 ! decreased size intersection_of: PATO:0000587 ! decreased size intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005634 ! nucleus relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005634 ! nucleus created_by: midori creation_date: 2011-07-14T05:04:23Z [Term] id: FYPO:0000366 name: decreased RNA localization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of RNA localization is decreased." [PomBase:mah] synonym: "decreased RNA localisation" EXACT [PomBase:mah] synonym: "decreased RNA localization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased RNA localization during vegetative growth" EXACT [PomBase:mah] synonym: "reduced RNA localization" EXACT [PomBase:mah] synonym: "RNA localization: decreased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000360 ! abnormal RNA localization during vegetative growth is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006403 ! RNA localization relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006403 ! RNA localization created_by: midori creation_date: 2011-07-14T06:06:09Z [Term] id: FYPO:0000368 name: abnormal vacuolar morphology during vegetative growth def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of the fungal-type vacuole is abnormal." [PomBase:mah] comment: Note that an abnormal vacuole organization process may, but does not necessarily, result in abnormal vacuolar morphology. synonym: "abnormal vacuolar morphology during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: FYPO:0002257 ! abnormal vacuolar morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: output_of FYPO:0000812 ! abnormal vacuole organization during vegetative growth relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-07-14T05:04:23Z [Term] id: FYPO:0000369 name: vacuoles absent def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells do not contain vacuoles." [PomBase:mah] synonym: "absent vacuolar morphology" EXACT [PomBase:mah] synonym: "vacuolar morphology: absent" EXACT [SGD:phenotype_annotation] synonym: "vacuoles absent during mitotic cell cycle" RELATED [PomBase:mah] synonym: "vacuoles absent during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0004638 ! abnormal cellular physical quality phenotype is_a: PATO:0002000 ! lacks all parts of type intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards GO:0000324 ! fungal-type vacuole relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards GO:0000324 ! fungal-type vacuole created_by: midori creation_date: 2011-07-14T05:04:23Z [Term] id: FYPO:0000370 name: abnormal RNA modification def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which RNA modification is abnormal. All RNA modification may be abnormal, or one or more specific RNA modifications may be selectively affected." [PomBase:mah] synonym: "abnormal RNA modification during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal RNA modification during vegetative growth" EXACT [PomBase:mah] synonym: "RNA modification: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000294 ! RNA metabolism phenotype is_a: FYPO:0001363 ! abnormal metabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0009451 ! RNA modification intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0009451 ! RNA modification relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-07-14T06:06:09Z [Term] id: FYPO:0000371 name: abolished RNA modification def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which RNA modification does not occur. All RNA modification may be abolished, or one or more specific RNA modifications may be selectively affected." [PomBase:mah] synonym: "abolished RNA modification during mitotic cell cycle" RELATED [PomBase:mah] synonym: "absent RNA modification" EXACT [PomBase:mah] synonym: "RNA modification abolished" EXACT [PomBase:mah] synonym: "RNA modification abolished during vegetative growth" EXACT [PomBase:mah] synonym: "RNA modification: absent" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000370 ! abnormal RNA modification is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0009451 ! RNA modification relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0009451 ! RNA modification created_by: midori creation_date: 2011-07-14T06:06:09Z [Term] id: FYPO:0000372 name: decreased RNA modification def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of RNA modification is decreased. All RNA modification may be decreased, or one or more specific RNA modifications may be selectively affected." [PomBase:mah] synonym: "decreased RNA modification during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased RNA modification during vegetative growth" EXACT [PomBase:mah] synonym: "reduced RNA modification" EXACT [PomBase:mah] synonym: "RNA modification: decreased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000370 ! abnormal RNA modification is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0009451 ! RNA modification relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0009451 ! RNA modification created_by: midori creation_date: 2011-07-14T06:06:09Z [Term] id: FYPO:0000373 name: decreased rate of RNA modification def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the rate, or speed, of RNA modification is decreased." [PomBase:mah] synonym: "decreased rate of RNA modification during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased rate of RNA modification during vegetative growth" EXACT [PomBase:mah] synonym: "reduced rate of RNA modification" EXACT [PomBase:mah] synonym: "RNA modification: decreased rate" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000370 ! abnormal RNA modification is_a: PATO:0000911 ! decreased rate intersection_of: PATO:0000911 ! decreased rate intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0009451 ! RNA modification relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0009451 ! RNA modification created_by: midori creation_date: 2011-07-14T06:06:09Z [Term] id: FYPO:0000374 name: increased RNA modification def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of RNA modification is increased. All RNA modification may be increased, or one or more specific RNA modifications may be selectively affected." [PomBase:mah] synonym: "increased RNA modification during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased RNA modification during vegetative growth" EXACT [PomBase:mah] synonym: "RNA modification: increased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000370 ! abnormal RNA modification is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0009451 ! RNA modification relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0009451 ! RNA modification created_by: midori creation_date: 2011-07-14T06:06:09Z [Term] id: FYPO:0000375 name: abolished apoptosis def: "A cellular process phenotype in which apoptosis does not occur. Apoptosis is a form of cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies." [GO:0006915, PomBase:mah] synonym: "absent apoptosis" EXACT [PomBase:mah] synonym: "apoptosis abolished" EXACT [PomBase:mah] synonym: "apoptosis: absent" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000629 ! abnormal apoptosis is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0006915 ! apoptotic process relationship: towards GO:0006915 ! apoptotic process created_by: midori creation_date: 2011-07-14T06:06:09Z [Term] id: FYPO:0000376 name: decreased apoptosis def: "A cellular process phenotype in which the occurrence of apoptosis is decreased. Apoptosis is a form of cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies." [GO:0006915, PomBase:mah] synonym: "apoptosis: decreased" EXACT [SGD:phenotype_annotation] synonym: "reduced apoptosis" EXACT [PomBase:mah] is_a: FYPO:0000629 ! abnormal apoptosis is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0006915 ! apoptotic process relationship: inheres_in GO:0006915 ! apoptotic process created_by: midori creation_date: 2011-07-14T06:06:09Z [Term] id: FYPO:0000377 name: increased apoptosis def: "A cellular process phenotype in which the occurrence of apoptosis is increased. Apoptosis is a form of cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies." [GO:0006915, PomBase:mah] synonym: "apoptosis: increased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000629 ! abnormal apoptosis is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0006915 ! apoptotic process relationship: inheres_in GO:0006915 ! apoptotic process created_by: midori creation_date: 2011-07-14T06:06:09Z [Term] id: FYPO:0000378 name: normal apoptosis def: "A cellular process phenotype in which apoptosis is normal (i.e. indistinguishable from wild type). Apoptosis is a form of cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies." [GO:0006915, PomBase:mah] synonym: "apoptosis: normal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001319 ! normal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006915 ! apoptotic process intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006915 ! apoptotic process relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-07-14T06:06:09Z [Term] id: FYPO:0000380 name: abolished autophagy def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which autophagy does not occur." [PomBase:mah] synonym: "absent autophagy" EXACT [PomBase:mah] synonym: "autophagy abolished" EXACT [PomBase:mah] synonym: "autophagy: absent" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000163 ! abnormal autophagy is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0006914 ! autophagy relationship: towards GO:0006914 ! autophagy created_by: midori creation_date: 2011-07-14T06:06:09Z [Term] id: FYPO:0000381 name: decreased autophagy def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of autophagy is decreased." [PomBase:mah] synonym: "autophagy: decreased" EXACT [SGD:phenotype_annotation] synonym: "reduced autophagy" EXACT [PomBase:mah] is_a: FYPO:0000163 ! abnormal autophagy is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0006914 ! autophagy relationship: inheres_in GO:0006914 ! autophagy created_by: midori creation_date: 2011-07-14T06:06:09Z [Term] id: FYPO:0000382 name: decreased rate of autophagy def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the rate, or speed, of autophagy is decreased." [PomBase:mah] synonym: "autophagy: decreased rate" EXACT [SGD:phenotype_annotation] synonym: "reduced rate of autophagy" EXACT [PomBase:mah] is_a: FYPO:0000163 ! abnormal autophagy is_a: PATO:0000911 ! decreased rate intersection_of: PATO:0000911 ! decreased rate intersection_of: inheres_in GO:0006914 ! autophagy relationship: inheres_in GO:0006914 ! autophagy created_by: midori creation_date: 2011-07-14T06:06:09Z [Term] id: FYPO:0000383 name: delayed autophagy def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which autophagy begins later than normal." [PomBase:mah] synonym: "autophagy: delayed" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000163 ! abnormal autophagy is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: inheres_in GO:0006914 ! autophagy relationship: inheres_in GO:0006914 ! autophagy created_by: midori creation_date: 2011-07-14T06:06:09Z [Term] id: FYPO:0000384 name: increased autophagy def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of autophagy is increased." [PomBase:mah] synonym: "autophagy: increased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000163 ! abnormal autophagy is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0006914 ! autophagy relationship: inheres_in GO:0006914 ! autophagy created_by: midori creation_date: 2011-07-14T06:06:09Z [Term] id: FYPO:0000385 name: normal autophagy def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which autophagy is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "autophagy: normal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0002496 ! normal metabolic process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0006914 ! autophagy intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0006914 ! autophagy relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-07-14T06:06:09Z [Term] id: FYPO:0000386 name: abolished biofilm formation def: "A cellular process phenotype in which biofilm formation does not occur." [PomBase:mah] synonym: "absent biofilm formation" EXACT [PomBase:mah] synonym: "biofilm formation abolished" EXACT [PomBase:mah] synonym: "biofilm formation: absent" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000630 ! abnormal biofilm formation is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0042710 ! biofilm formation relationship: towards GO:0042710 ! biofilm formation created_by: midori creation_date: 2011-07-14T06:06:09Z [Term] id: FYPO:0000387 name: decreased biofilm formation def: "A cellular process phenotype in which the occurrence of biofilm formation is decreased." [PomBase:mah] synonym: "biofilm formation: decreased" EXACT [SGD:phenotype_annotation] synonym: "reduced biofilm formation" EXACT [PomBase:mah] is_a: FYPO:0000630 ! abnormal biofilm formation is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0042710 ! biofilm formation relationship: inheres_in GO:0042710 ! biofilm formation created_by: midori creation_date: 2011-07-14T06:06:09Z [Term] id: FYPO:0000388 name: increased biofilm formation def: "A cellular process phenotype in which the occurrence of biofilm formation is increased." [PomBase:mah] synonym: "biofilm formation: increased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000630 ! abnormal biofilm formation is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0042710 ! biofilm formation relationship: inheres_in GO:0042710 ! biofilm formation created_by: midori creation_date: 2011-07-14T06:06:09Z [Term] id: FYPO:0000389 name: cell cycle arrest at mitotic START def: "A cellular process phenotype in which traversing the start control point of the mitotic cell cycle is arrested." [PomBase:mah] synonym: "cell cycle arrest at mitotic START during vegetative growth" EXACT [PomBase:mah] synonym: "cell cycle passage through START: arrested" EXACT [SGD:phenotype_annotation] synonym: "mitotic cell cycle arrest at START" EXACT [PomBase:mah] is_a: FYPO:0000837 ! cell cycle arrest in mitotic interphase intersection_of: during GO:0007089 ! traversing start control point of mitotic cell cycle intersection_of: inheres_in GO:0071850 ! mitotic cell cycle arrest intersection_of: qualifier PATO:0000467 ! present relationship: during GO:0007089 ! traversing start control point of mitotic cell cycle relationship: inheres_in GO:0071850 ! mitotic cell cycle arrest relationship: qualifier PATO:0000467 ! present created_by: midori creation_date: 2011-07-14T06:06:09Z [Term] id: FYPO:0000390 name: advanced passage through START of mitotic cell cycle def: "A cellular process phenotype in which traversing the start control point of the mitotic cell cycle begins earlier than normal." [PomBase:mah] synonym: "advanced mitotic cell cycle passage through START" EXACT [PomBase:mah] synonym: "advanced passage through START of mitotic cell cycle during vegetative growth" EXACT [PomBase:mah] synonym: "cell cycle passage through START: increased rate" RELATED [SGD:phenotype_annotation] synonym: "premature passage through START of mitotic cell cycle" EXACT [PomBase:mah] is_a: FYPO:0000148 ! abnormal regulation of mitotic cell cycle is_a: FYPO:0000827 ! advanced cell cycle phase transition is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0007089 ! traversing start control point of mitotic cell cycle relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0007089 ! traversing start control point of mitotic cell cycle created_by: midori creation_date: 2011-07-14T06:06:09Z [Term] id: FYPO:0000391 name: normal passage through START of mitotic cell cycle def: "A cellular process phenotype in which traversing the start control point of the mitotic cell cycle is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "cell cycle passage through START: normal" EXACT [SGD:phenotype_annotation] synonym: "normal mitotic cell cycle passage through START" EXACT [PomBase:mah] synonym: "normal passage through START of mitotic cell cycle during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001928 ! normal regulation of mitotic cell cycle intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0007089 ! traversing start control point of mitotic cell cycle intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0007089 ! traversing start control point of mitotic cell cycle relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-07-14T06:06:09Z [Term] id: FYPO:0000392 name: abnormal cell cycle arrest at mitotic metaphase/anaphase transition def: "A cellular process phenotype in which progression through the mitotic cell cycle is arrested at the metaphase/anaphase transition under conditions where arrest does not normally occur." [PomBase:mah] synonym: "abnormal cell cycle arrest at mitotic metaphase/anaphase transition" EXACT [PomBase:mah] synonym: "abnormal cell cycle arrest at mitotic metaphase/anaphase transition during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal cell cycle arrest at mitotic metaphase/anaphase transition with condensed chromosomes" EXACT [PomBase:vw] synonym: "abnormal mitotic cell cycle arrest at metaphase/anaphase transition" EXACT [PomBase:mah] synonym: "abnormal mitotic metaphase/anaphase arrest" EXACT [PomBase:mah] synonym: "cell cycle passage through the metaphase-anaphase transition: arrested" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000608 ! abnormal cell cycle arrest in mitotic M phase intersection_of: during GO:0007091 ! metaphase/anaphase transition of mitotic cell cycle intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0071850 ! mitotic cell cycle arrest intersection_of: qualifier PATO:0000467 ! present relationship: during GO:0007091 ! metaphase/anaphase transition of mitotic cell cycle relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0001946 ! abolished mitotic sister chromatid separation relationship: inheres_in_part_of GO:0071850 ! mitotic cell cycle arrest relationship: qualifier PATO:0000467 ! present created_by: midori creation_date: 2011-07-14T06:06:09Z [Term] id: FYPO:0000394 name: abnormal mitotic G1/S phase transition def: "A cellular process phenotype in which the G1/S transition of the mitotic cell cycle is abnormal." [PomBase:mah] synonym: "abnormal cell cycle progression through the G1/S phase transition" EXACT [PomBase:mah] synonym: "abnormal mitotic cell cycle G1/S phase transition" EXACT [PomBase:mah] synonym: "abnormal mitotic G1/S cell cycle phase transition" EXACT [PomBase:mah] synonym: "abnormal mitotic G1/S phase transition during vegetative growth" EXACT [PomBase:mah] synonym: "cell cycle progression through the G1/S phase transition: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0002737 ! abnormal mitotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000082 ! G1/S transition of mitotic cell cycle intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000082 ! G1/S transition of mitotic cell cycle relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-07-14T06:06:09Z [Term] id: FYPO:0000395 name: cell cycle arrest at mitotic G1/S phase transition def: "A cellular process phenotype in which progression through the mitotic cell cycle is arrested at the G1/S transition." [PomBase:mah] synonym: "abnormal cell cycle arrest at mitotic G1/S phase transition" EXACT [PomBase:mah] synonym: "abnormal mitotic cell cycle arrest at G1/S phase transition" EXACT [PomBase:mah] synonym: "cell cycle progression through the G1/S phase transition: arrested" EXACT [SGD:phenotype_annotation] synonym: "mitotic cell cycle arrest at G1/S phase transition" EXACT [PomBase:mah] synonym: "mitotic cell cycle arrest at G1/S phase transition during vegetative growth" EXACT [PomBase:mah] synonym: "mitotic G1/S phase arrest" EXACT [PomBase:mah] is_a: FYPO:0000445 ! cell cycle arrest in mitotic G1 phase intersection_of: during GO:0000082 ! G1/S transition of mitotic cell cycle intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071850 ! mitotic cell cycle arrest intersection_of: qualifier PATO:0000467 ! present relationship: during GO:0000082 ! G1/S transition of mitotic cell cycle relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071850 ! mitotic cell cycle arrest relationship: qualifier PATO:0000467 ! present created_by: midori creation_date: 2011-07-14T06:06:09Z [Term] id: FYPO:0000397 name: decreased duration of mitotic G1/S phase transition def: "A cellular process phenotype in which the duration of progression through the G1/S transition of the mitotic cell cycle is shorter than normal." [PomBase:mah] comment: This term was made obsolete because a cell cycle transition is a time point, rather than a stage or phase that can have a duration. synonym: "cell cycle progression through the G1/S phase transition: increased rate" RELATED [SGD:phenotype_annotation] synonym: "decreased duration of cell cycle progression through mitotic G1/S phase transition" EXACT [PomBase:mah] synonym: "decreased duration of mitotic G1/S phase transition during vegetative growth" EXACT [PomBase:mah] synonym: "increased rate of cell cycle progression through mitotic G1/S phase transition" RELATED [PomBase:mah] synonym: "reduced duration of mitotic G1/S phase transition" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2011-07-14T06:06:09Z [Term] id: FYPO:0000398 name: advanced mitotic G1/S phase transition def: "A cellular process phenotype in which progression through the G1/S transition of the mitotic cell cycle begins earlier than normal." [PomBase:mah] synonym: "advanced mitotic G1/S phase transition during vegetative growth" EXACT [PomBase:mah] synonym: "cell cycle progression through the G1/S phase transition: premature" EXACT [SGD:phenotype_annotation] synonym: "premature cell cycle progression through mitotic G1/S phase transition" EXACT [PomBase:mah] synonym: "premature mitotic G1/S phase transition" EXACT [PomBase:mah] synonym: "premature mitotic G1/S phase transition during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000394 ! abnormal mitotic G1/S phase transition is_a: FYPO:0000827 ! advanced cell cycle phase transition intersection_of: PATO:0000694 ! premature intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000082 ! G1/S transition of mitotic cell cycle relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000082 ! G1/S transition of mitotic cell cycle created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000399 name: abnormal mitotic G2/M phase transition def: "A cellular process phenotype in which the G2/M transition of the mitotic cell cycle is abnormal." [PomBase:mah] synonym: "abnormal cell cycle progression through mitotic G2/M phase transition" EXACT [PomBase:mah] synonym: "abnormal cell cycle progression through mitotic G2/M phase transition during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal mitotic cell cycle G2/M phase transition" EXACT [PomBase:mah] synonym: "abnormal mitotic G2/M cell cycle phase transition" EXACT [PomBase:mah] synonym: "cell cycle progression through the G2/M phase transition: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0002737 ! abnormal mitotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000086 ! G2/M transition of mitotic cell cycle intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000086 ! G2/M transition of mitotic cell cycle relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000400 name: cell cycle arrest at mitotic G2/M phase transition def: "A cellular process phenotype in which progression through the mitotic cell cycle is arrested at the G2/M transition." [PomBase:mah] synonym: "abnormal cell cycle arrest at mitotic G2/M phase transition" EXACT [PomBase:mah] synonym: "cell cycle arrest at mitotic G2/M phase transition during vegetative growth" EXACT [PomBase:mah] synonym: "cell cycle progression through the G2/M phase transition: arrested" EXACT [SGD:phenotype_annotation] synonym: "mitotic cell cycle arrest at G2/M phase transition" EXACT [PomBase:mah] synonym: "mitotic G2/M phase arrest" EXACT [PomBase:mah] is_a: FYPO:0000446 ! cell cycle arrest in mitotic G2 phase intersection_of: during GO:0000086 ! G2/M transition of mitotic cell cycle intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071850 ! mitotic cell cycle arrest intersection_of: qualifier PATO:0000467 ! present relationship: during GO:0000086 ! G2/M transition of mitotic cell cycle relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071850 ! mitotic cell cycle arrest relationship: qualifier PATO:0000467 ! present created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000402 name: increased mitotic G2/M phase transition def: "A cellular process phenotype in which the occurrence of progression through the G2/M transition of the mitotic cell cycle is increased." [PomBase:mah] synonym: "cell cycle progression through the G2/M phase transition: increased" EXACT [SGD:phenotype_annotation] synonym: "increased cell cycle progression through mitotic G2/M phase transition" EXACT [PomBase:mah] synonym: "increased occurrence of mitotic G2/M phase transition during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000399 ! abnormal mitotic G2/M phase transition is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000086 ! G2/M transition of mitotic cell cycle relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000086 ! G2/M transition of mitotic cell cycle created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000403 name: increased duration of mitotic G2/M phase transition def: "A cellular process phenotype in which the duration of progression through the G2/M transition of the mitotic cell cycle is increased." [PomBase:mah] comment: This term was made obsolete because a cell cycle transition is a time point, rather than a stage or phase that can have a duration. synonym: "cell cycle progression through the G2/M phase transition: increased duration" EXACT [SGD:phenotype_annotation] synonym: "increased duration of cell cycle progression through mitotic G2/M phase transition" EXACT [PomBase:mah] synonym: "increased duration of mitotic G2/M phase transition during vegetative growth" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000404 name: decreased duration of mitotic G2/M phase transition def: "A cellular process phenotype in which the duration of progression through the G2/M transition of the mitotic cell cycle is shorter than normal." [PomBase:mah] comment: This term was made obsolete because a cell cycle transition is a time point, rather than a stage or phase that can have a duration. synonym: "cell cycle progression through the G2/M phase transition: increased rate" EXACT [SGD:phenotype_annotation] synonym: "decreased duration of cell cycle progression through mitotic G2/M phase transition" EXACT [PomBase:mah] synonym: "decreased duration of cell cycle progression through mitotic G2/M phase transition during vegetative growth" EXACT [PomBase:mah] synonym: "increased rate of mitotic G2/M phase transition" RELATED [PomBase:mah] synonym: "reduced duration of mitotic G2/M phase transition" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000405 name: normal mitotic G2/M phase transition def: "A cellular process phenotype in which the G2/M transition of the mitotic cell cycle is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "cell cycle progression through the G2/M phase transition: normal" EXACT [SGD:phenotype_annotation] synonym: "normal cell cycle progression through mitotic G2/M phase transition" EXACT [PomBase:mah] synonym: "normal mitotic G2/M phase transition during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002741 ! normal mitotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000086 ! G2/M transition of mitotic cell cycle intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000086 ! G2/M transition of mitotic cell cycle relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000407 name: abnormally arrested cell cycle progression def: "A cellular process phenotype in which cell cycle progression is arrested under conditions where arrest does not normally occur." [PomBase:mah] comment: Note that this term should be used only for cell cycle arrest that occurs in mutants but not in wild type cells. For phenotypes affecting cell cycle that normally occurs, e.g. in response to mating pheromone, see 'normally arrested mitotic cell cycle progression' (FYPO:0001025), 'abnormal occurrence of normal mitotic cell cycle arrest' (FYPO:0001026), and their child terms. synonym: "abnormal cell cycle arrest" EXACT [PomBase:mah] synonym: "abnormally arrested cell cycle progression during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormally arrested cell cycle progression during vegetative growth" EXACT [PomBase:mah] synonym: "cell cycle progression: arrested" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001024 ! cell cycle arrest phenotype is_a: FYPO:0002734 ! abnormal cell cycle process is_a: PATO:0001561 ! having extra processual parts intersection_of: PATO:0001561 ! having extra processual parts intersection_of: towards GO:0007050 ! cell cycle arrest relationship: towards GO:0007050 ! cell cycle arrest created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000408 name: increased duration of cell cycle phase def: "A cellular process phenotype in which the duration of one or more cell cycle phases is longer than normal." [PomBase:mah] synonym: "cell cycle progression: decreased rate" RELATED [SGD:phenotype_annotation] synonym: "decreased rate of cell cycle progression" RELATED [PomBase:mah] synonym: "prolonged cell cycle phase" EXACT [PomBase:mah] synonym: "reduced rate of cell cycle progression" RELATED [PomBase:mah] is_a: FYPO:0002735 ! abnormal cell cycle phase is_a: PATO:0000498 ! increased duration intersection_of: PATO:0000498 ! increased duration intersection_of: inheres_in GO:0022403 ! cell cycle phase relationship: inheres_in GO:0022403 ! cell cycle phase created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000409 name: delayed cell cycle phase transition def: "A cellular process phenotype in which one or more cell cycle phase transitions begins later than normal." [PomBase:mah] synonym: "cell cycle progression: delayed" EXACT [SGD:phenotype_annotation] synonym: "delayed cell cycle phase transition during mitotic cell cycle" RELATED [PomBase:mah] synonym: "delayed cell cycle phase transition during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0002734 ! abnormal cell cycle process is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0044770 ! cell cycle phase transition relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0044770 ! cell cycle phase transition created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000410 name: decreased duration of cell cycle phase def: "A cellular process phenotype in which the duration of one or more cell cycle phases is shorter than normal." [PomBase:mah] synonym: "cell cycle progression: increased rate" RELATED [SGD:phenotype_annotation] synonym: "increased rate of cell cycle progression" RELATED [PomBase:mah] synonym: "reduced duration of cell cycle phase" EXACT [PomBase:mah] is_a: FYPO:0002735 ! abnormal cell cycle phase is_a: PATO:0000499 ! decreased duration intersection_of: PATO:0000499 ! decreased duration intersection_of: inheres_in GO:0022403 ! cell cycle phase relationship: inheres_in GO:0022403 ! cell cycle phase created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000411 name: normal mitotic cell cycle def: "A cellular process phenotype in which mitotic cell cycle progression is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "mitotic cell cycle progression: normal" EXACT [SGD:phenotype_annotation] synonym: "normal cell cycle during vegetative growth" EXACT [PomBase:mah] synonym: "normal mitotic cell cycle progression" EXACT [PomBase:mah] synonym: "normal mitotic cell-division cycle" EXACT [GO:0007049, PomBase:mah] is_a: FYPO:0003832 ! normal cell cycle intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000278 ! mitotic cell cycle intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000278 ! mitotic cell cycle relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000412 name: abnormal cell fusion during conjugation def: "A cellular process phenotype in which plasma membrane fusion involved in cytogamy is abnormal." [PomBase:mah] synonym: "abnormal cell fusion during mating" EXACT [PomBase:mah] synonym: "abnormal plasma membrane fusion involved in cytogamy" EXACT [GO:0032220] synonym: "cell fusion: abnormal" RELATED [SGD:phenotype_annotation] is_a: FYPO:0000031 ! abnormal conjugation is_a: FYPO:0001013 ! abnormal membrane organization intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0032220 ! plasma membrane fusion involved in cytogamy intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0032220 ! plasma membrane fusion involved in cytogamy relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000413 name: abolished cell fusion during conjugation def: "A cellular process phenotype in which plasma membrane fusion involved in cytogamy does not occur." [PomBase:mah] synonym: "abolished cell fusion during mating" EXACT [PomBase:mah] synonym: "abolished plasma membrane fusion involved in cytogamy" EXACT [GO:0032220] synonym: "absent cell fusion during conjugation" EXACT [PomBase:mah] synonym: "cell fusion abolished during conjugation" EXACT [PomBase:mah] synonym: "cell fusion: absent" RELATED [SGD:phenotype_annotation] is_a: FYPO:0000412 ! abnormal cell fusion during conjugation is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0032220 ! plasma membrane fusion involved in cytogamy relationship: towards GO:0032220 ! plasma membrane fusion involved in cytogamy created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000414 name: decreased cell fusion during conjugation def: "A cellular process phenotype in which plasma membrane fusion involved in cytogamy is decreased." [PomBase:mah] synonym: "cell fusion: decreased" RELATED [SGD:phenotype_annotation] synonym: "decreased cell fusion during mating" EXACT [PomBase:mah] synonym: "decreased plasma membrane fusion involved in cytogamy" EXACT [GO:0032220] synonym: "reduced cell fusion during conjugation" EXACT [PomBase:mah] is_a: FYPO:0000412 ! abnormal cell fusion during conjugation is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0032220 ! plasma membrane fusion involved in cytogamy relationship: inheres_in GO:0032220 ! plasma membrane fusion involved in cytogamy created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000415 name: decreased mitotic sister chromatid segregation def: "A cellular process phenotype in which the occurrence of mitotic sister chromatid segregation is decreased." [PomBase:mah] synonym: "chromosome segregation: decreased" BROAD [SGD:phenotype_annotation] synonym: "decreased chromosome segregation during vegetative growth" EXACT [PomBase:mah] synonym: "decreased mitotic chromosome segregation" EXACT [GO:0000070] synonym: "reduced mitotic sister chromatid segregation" EXACT [PomBase:mah] is_a: FYPO:0000141 ! abnormal mitotic sister chromatid segregation is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000070 ! mitotic sister chromatid segregation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000070 ! mitotic sister chromatid segregation created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000416 name: premature mitotic sister chromatid segregation def: "A cellular process phenotype in which mitotic sister chromatid segregation occurs prematurely." [PomBase:mah] synonym: "advanced mitotic sister chromatid segregation" EXACT [PomBase:mah] synonym: "chromosome segregation: premature" BROAD [SGD:phenotype_annotation] synonym: "premature chromosome segregation during vegetative growth" EXACT [PomBase:mah] synonym: "premature mitotic chromosome segregation" EXACT [GO:0000070] is_a: FYPO:0000141 ! abnormal mitotic sister chromatid segregation is_a: PATO:0000694 ! premature intersection_of: PATO:0000694 ! premature intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000070 ! mitotic sister chromatid segregation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000070 ! mitotic sister chromatid segregation created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000417 name: abolished cytokinesis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitotic cytokinesis does not occur." [PomBase:mah] synonym: "absent cytokinesis" EXACT [PomBase:mah] synonym: "cytokinesis abolished" EXACT [PomBase:mah] synonym: "cytokinesis abolished during vegetative growth" EXACT [PomBase:mah] synonym: "cytokinesis: absent" EXACT [SGD:phenotype_annotation] synonym: "mitotic cytokinesis abolished" EXACT [GO:0000281, PomBase:mah] is_a: FYPO:0000032 ! abnormal cytokinesis is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0000281 ! mitotic cytokinesis relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0000281 ! mitotic cytokinesis created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000418 name: decreased cytokinesis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of mitotic cytokinesis is decreased." [PomBase:mah] synonym: "cytokinesis: decreased" EXACT [SGD:phenotype_annotation] synonym: "decreased cytokinesis during vegetative growth" EXACT [PomBase:mah] synonym: "decreased mitotic cytokinesis" EXACT [GO:0000281, PomBase:mah] synonym: "reduced cytokinesis" EXACT [PomBase:mah] is_a: FYPO:0000032 ! abnormal cytokinesis is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000281 ! mitotic cytokinesis relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000281 ! mitotic cytokinesis created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000419 name: decreased rate of cytokinesis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the rate, or speed, of mitotic cytokinesis is decreased." [PomBase:mah] synonym: "cytokinesis: decreased rate" EXACT [SGD:phenotype_annotation] synonym: "decreased rate of cytokinesis during vegetative growth" EXACT [PomBase:mah] synonym: "decreased rate of mitotic cytokinesis" EXACT [GO:0000281, PomBase:mah] synonym: "reduced rate of cytokinesis" EXACT [PomBase:mah] is_a: FYPO:0000032 ! abnormal cytokinesis is_a: PATO:0000911 ! decreased rate intersection_of: PATO:0000911 ! decreased rate intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000281 ! mitotic cytokinesis relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000281 ! mitotic cytokinesis created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000420 name: delayed cytokinesis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitotic cytokinesis begins later than normal." [PomBase:mah] synonym: "cytokinesis: delayed" EXACT [SGD:phenotype_annotation] synonym: "delayed cytokinesis during vegetative growth" EXACT [PomBase:mah] synonym: "delayed mitotic cytokinesis" EXACT [GO:0000281, PomBase:mah] is_a: FYPO:0000032 ! abnormal cytokinesis is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000281 ! mitotic cytokinesis relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000281 ! mitotic cytokinesis created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000421 name: abolished endocytosis during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which endocytosis does not occur. A phenotype may affect endocytosis of all cargoes, or of specific cargo such as a particular protein." [PomBase:mah] synonym: "abolished actin-mediated endocytosis during vegetative growth" EXACT [PomBase:vw] synonym: "abolished endocytosis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein internalization during vegetative growth" NARROW [PomBase:vw] synonym: "absent endocytosis during vegetative growth" EXACT [PomBase:mah] synonym: "endocytosis abolished during vegetative growth" EXACT [PomBase:mah] synonym: "endocytosis: absent during vegetative growth" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000034 ! abnormal endocytosis during vegetative growth is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0006897 ! endocytosis relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_output FYPO:0003504 ! increased protein level in plasma membrane relationship: towards GO:0006897 ! endocytosis created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000422 name: decreased endocytosis during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of endocytosis is decreased. A phenotype may affect endocytosis of all cargoes, or of specific cargo such as a particular protein." [PomBase:mah] synonym: "decreased endocytosis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein internalization during vegetative growth" NARROW [PomBase:vw] synonym: "endocytosis: decreased during vegetative growth" EXACT [SGD:phenotype_annotation] synonym: "reduced actin-mediated endocytosis during vegetative growth" EXACT [PomBase:vw] synonym: "reduced endocytosis during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000034 ! abnormal endocytosis during vegetative growth is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006897 ! endocytosis relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_output FYPO:0003504 ! increased protein level in plasma membrane relationship: inheres_in GO:0006897 ! endocytosis created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000423 name: decreased rate of endocytosis during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the rate, or speed, of endocytosis is decreased. A phenotype may affect endocytosis of all cargoes, or of specific cargo such as a particular protein." [PomBase:mah] synonym: "decreased rate of actin-mediated endocytosis during vegetative growth" EXACT [PomBase:vw] synonym: "decreased rate of endocytosis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased rate of protein internalization during vegetative growth" NARROW [PomBase:vw] synonym: "endocytosis: decreased rate during vegetative growth" EXACT [SGD:phenotype_annotation] synonym: "reduced rate of endocytosis during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000034 ! abnormal endocytosis during vegetative growth is_a: PATO:0000911 ! decreased rate intersection_of: PATO:0000911 ! decreased rate intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006897 ! endocytosis relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006897 ! endocytosis created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000424 name: delayed endocytosis during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which endocytosis begins later than normal. A phenotype may affect endocytosis of all cargoes, or of specific cargo such as a particular protein." [PomBase:mah] synonym: "delayed actin-mediated endocytosis during vegetative growth" EXACT [PomBase:vw] synonym: "delayed endocytosis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "delayed protein internalization during vegetative growth" NARROW [PomBase:vw] synonym: "endocytosis: delayed during vegetative growth" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000034 ! abnormal endocytosis during vegetative growth is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006897 ! endocytosis relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006897 ! endocytosis created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000425 name: increased endocytosis during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of endocytosis is increased. A phenotype may affect endocytosis of all cargoes, or of specific cargo such as a particular protein." [PomBase:mah] synonym: "endocytosis: increased during vegetative growth" EXACT [SGD:phenotype_annotation] synonym: "increased actin-mediated endocytosis during vegetative growth" EXACT [PomBase:vw] synonym: "increased endocytosis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein internalization during vegetative growth" NARROW [PomBase:vw] is_a: FYPO:0000034 ! abnormal endocytosis during vegetative growth is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006897 ! endocytosis relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006897 ! endocytosis created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000426 name: normal endocytosis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which endocytosis is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "endocytosis: normal" EXACT [SGD:phenotype_annotation] synonym: "normal endocytosis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal endocytosis during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001071 ! normal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006897 ! endocytosis intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006897 ! endocytosis relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000427 name: abnormal G1 to G0 transition def: "A cellular process phenotype in which the G1 to G0 transition is abnormal." [PomBase:mah] synonym: "abnormal cell cycle quiescence" RELATED [GO:0070314, PomBase:mah] synonym: "abnormal establishment of cell quiescence" EXACT [GO:0070314, PomBase:mah] synonym: "abnormal G1/G0 transition" EXACT [GO:0070314, PomBase:mah] is_a: FYPO:0000145 ! regulation phenotype is_a: FYPO:0002734 ! abnormal cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0070314 ! G1 to G0 transition intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0070314 ! G1 to G0 transition relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000428 name: abolished entry into G0 def: "A cellular process phenotype in which the G1 to G0 transition does not occur." [PomBase:mah] synonym: "cell cycle quiescence abolished" RELATED [GO:0070314, PomBase:mah] synonym: "entry into G0 abolished" EXACT [PomBase:mah] synonym: "establishment of cell quiescence abolished" EXACT [GO:0070314, PomBase:mah] synonym: "G1/G0 transition abolished" EXACT [GO:0070314, PomBase:mah] is_a: FYPO:0000427 ! abnormal G1 to G0 transition is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0070314 ! G1 to G0 transition relationship: towards GO:0070314 ! G1 to G0 transition created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000429 name: delayed G0 to G1 transition def: "A cellular process phenotype in which the G0 to G1 transition begins later than normal." [PomBase:mah] synonym: "delayed G0/G1 transition" EXACT [PomBase:mah] synonym: "slow cell population growth following nitrogen starvation" RELATED [PomBase:al] is_a: FYPO:0000628 ! abnormal cellular process is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: inheres_in GO:0045023 ! G0 to G1 transition relationship: inheres_in GO:0045023 ! G0 to G1 transition created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000430 name: abnormal fermentation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which fermentation is abnormal." [PomBase:mah] synonym: "abnormal fermentation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal fermentation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal fermentative metabolism" EXACT [PomBase:mah] synonym: "fermentative metabolism: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001363 ! abnormal metabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006113 ! fermentation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006113 ! fermentation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000431 name: abolished fermentation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which fermentation does not occur." [PomBase:mah] synonym: "abolished fermentation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "absent fermentative metabolism" EXACT [PomBase:mah] synonym: "fermentation abolished" EXACT [PomBase:mah] synonym: "fermentation abolished during vegetative growth" EXACT [PomBase:mah] synonym: "fermentative metabolism abolished" EXACT [PomBase:mah] synonym: "fermentative metabolism: absent" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000430 ! abnormal fermentation is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0006113 ! fermentation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0006113 ! fermentation created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000432 name: decreased fermentation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of fermentation is decreased." [PomBase:mah] synonym: "decreased fermentation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased fermentation during vegetative growth" EXACT [PomBase:mah] synonym: "decreased fermentative metabolism" EXACT [PomBase:mah] synonym: "fermentative metabolism: decreased" EXACT [SGD:phenotype_annotation] synonym: "reduced fermentation" EXACT [PomBase:mah] is_a: FYPO:0000430 ! abnormal fermentation is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006113 ! fermentation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006113 ! fermentation created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000433 name: increased fermentation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of fermentation is increased." [PomBase:mah] synonym: "fermentative metabolism: increased" EXACT [SGD:phenotype_annotation] synonym: "increased fermentation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased fermentation during vegetative growth" EXACT [PomBase:mah] synonym: "increased fermentative metabolism" EXACT [PomBase:mah] is_a: FYPO:0000430 ! abnormal fermentation is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006113 ! fermentation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006113 ! fermentation created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000434 name: normal fermentation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which fermentation is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "fermentative metabolism: normal" EXACT [SGD:phenotype_annotation] synonym: "normal fermentation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal fermentation during vegetative growth" EXACT [PomBase:mah] synonym: "normal fermentative metabolism" EXACT [PomBase:mah] is_a: FYPO:0000859 ! normal metabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006113 ! fermentation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006113 ! fermentation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-07-14T06:45:37Z [Term] id: FYPO:0000440 name: sensitive to antimycin A def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to antimycin A. Cells stop growing (and may die) at a concentration of antimycin A that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to antimycin A" EXACT [PomBase:mah] synonym: "sensitive to antimycin A during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to antimycin A during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:22584 ! antimycin A relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:22584 ! antimycin A created_by: midori creation_date: 2011-08-03T04:41:43Z [Term] id: FYPO:0000441 name: resistance to antimycin A def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of antimycin than normal." [PomBase:mah] synonym: "resistance to antimycin A during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to antimycin A during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to antimycin A" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:22584 ! antimycin A relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:22584 ! antimycin A created_by: midori creation_date: 2011-08-03T04:41:43Z [Term] id: FYPO:0000442 name: decreased cell population growth on glycerol/ethanol carbon source def: "A vegetative cell population growth phenotype in which cell growth is decreased relative to normal in a medium containing glycerol and ethanol as the carbon sources." [PomBase:mah] comment: Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "decreased cell growth on glycerol plus ethanol" EXACT [PomBase:mah] synonym: "decreased growth on glycerol/ethanol carbon source" BROAD [PomBase:mah] synonym: "decreased vegetative cell growth on glycerol/ethanol carbon source" EXACT [PomBase:mah] synonym: "reduced cell growth on glycerol/ethanol carbon source" RELATED [PomBase:mah] synonym: "slow cell growth on glycerol/ethanol carbon source" NARROW [PomBase:mah] is_a: FYPO:0001355 ! decreased vegetative cell population growth created_by: midori creation_date: 2011-08-03T05:18:32Z [Term] id: FYPO:0000443 name: abnormal protein localization during vegetative growth def: "A cell phenotype that affects the localization of a protein in a cell in the vegetative growth phase of the life cycle. A protein may be observed in a place where it is not normally found, absent from a place where it is normally found, or both." [PomBase:mah] comment: We recommend using one of the more specific terms instead of annotating to this term directly, if possible. If this term is used, we recommend noting which protein(s) were used in the assay. subset: qc_do_not_manually_annotate synonym: "abnormal cellular protein localisation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal cellular protein localization during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal protein localisation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal protein localization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein/peptide distribution: abnormal" RELATED [SGD:phenotype_annotation] is_a: FYPO:0001337 ! localization phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0001370 ! abnormal protein localization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0034613 ! cellular protein localization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0034613 ! cellular protein localization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-04T04:19:46Z [Term] id: FYPO:0000444 name: abnormal mitotic cell cycle arrest with replicated DNA def: "A cellular process phenotype in which progression through the mitotic cell cycle is arrested when cells have replicated genomic DNA, under conditions where arrest does not normally occur." [PomBase:mah] comment: Arrest with replicated DNA may occur between late S and G2/M; if only DNA content is measured, the arrest point cannot be determined with greater precision. synonym: "abnormal mitotic cell cycle arrest with 2C DNA content" NARROW [PomBase:mah] synonym: "abnormal mitotic cell cycle arrest with replicated DNA" EXACT [PomBase:mah] synonym: "abnormal mitotic cell cycle arrest with replicated DNA during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000502 ! abnormally arrested mitotic cell cycle progression intersection_of: FYPO:0000407 ! abnormally arrested cell cycle progression intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: preceded_by GO:1902969 ! mitotic DNA replication relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: preceded_by GO:1902969 ! mitotic DNA replication created_by: midori creation_date: 2011-08-12T02:03:05Z [Term] id: FYPO:0000445 name: cell cycle arrest in mitotic G1 phase def: "A cellular process phenotype in which progression through the mitotic cell cycle is arrested in G1 phase." [PomBase:mah] comment: For phenotypes affecting the G1 cell cycle that normally occurs in response to mating pheromone, see 'abnormal cell cycle arrest in response to pheromone' (FYPO:0000530) and its child terms. synonym: "cell cycle arrest in mitotic G1 phase during vegetative growth" EXACT [PomBase:mah] synonym: "mitotic cell cycle arrest in G1 phase" EXACT [PomBase:mah] synonym: "mitotic cell cycle progression in G1 phase: arrested" EXACT [SGD:phenotype_annotation] synonym: "mitotic G1 phase arrest" EXACT [PomBase:mah] is_a: FYPO:0000837 ! cell cycle arrest in mitotic interphase intersection_of: during GO:0000080 ! mitotic G1 phase intersection_of: inheres_in GO:0071850 ! mitotic cell cycle arrest intersection_of: qualifier PATO:0000467 ! present relationship: during GO:0000080 ! mitotic G1 phase relationship: inheres_in GO:0071850 ! mitotic cell cycle arrest relationship: qualifier PATO:0000467 ! present created_by: midori creation_date: 2011-08-12T02:07:59Z [Term] id: FYPO:0000446 name: cell cycle arrest in mitotic G2 phase def: "A cellular process phenotype in which progression through the mitotic cell cycle is arrested in G2 phase." [PomBase:mah] synonym: "cell cycle arrest in mitotic G2 phase during vegetative growth" EXACT [PomBase:mah] synonym: "mitotic cell cycle arrest in G2 phase" EXACT [PomBase:mah] synonym: "mitotic cell cycle progression in G2 phase: arrested" EXACT [SGD:phenotype_annotation] synonym: "mitotic G2 phase arrest" EXACT [PomBase:mah] is_a: FYPO:0000837 ! cell cycle arrest in mitotic interphase intersection_of: during GO:0000085 ! mitotic G2 phase intersection_of: inheres_in GO:0071850 ! mitotic cell cycle arrest intersection_of: qualifier PATO:0000467 ! present relationship: during GO:0000085 ! mitotic G2 phase relationship: inheres_in GO:0071850 ! mitotic cell cycle arrest relationship: qualifier PATO:0000467 ! present created_by: midori creation_date: 2011-08-12T02:11:06Z [Term] id: FYPO:0000447 name: abnormal protein complex assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which any process of protein complex assembly at the cellular level is abnormal." [PomBase:mah] synonym: "abnormal protein complex assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein complex assembly during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001354 ! abnormal cellular component assembly during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0043623 ! cellular protein complex assembly intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0043623 ! cellular protein complex assembly relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-12T02:26:26Z [Term] id: FYPO:0000448 name: abnormal MCM complex assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which MCM complex assembly is abnormal." [PomBase:mah] synonym: "abnormal MCM complex assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal MCM complex assembly during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000447 ! abnormal protein complex assembly intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0072689 ! MCM complex assembly intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0072689 ! MCM complex assembly relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-12T02:27:22Z [Term] id: FYPO:0000449 name: abnormal protein localization to centromere def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the centromere of a chromosome is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found at the centromere and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to centromere" EXACT [PomBase:mah] synonym: "abnormal protein localisation to chromosome, centromeric region" EXACT [GO:0071459, PomBase:mah] synonym: "abnormal protein localization to centromere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein localization to centromere during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal protein localization to chromosome, centric region" EXACT [GO:0071459, PomBase:mah] synonym: "abnormal protein localization to chromosome, centromeric region" EXACT [GO:0071459, PomBase:mah] is_a: FYPO:0002838 ! abnormal protein localization to chromosome intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0071459 ! protein localization to chromosome, centromeric region intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0071459 ! protein localization to chromosome, centromeric region relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-12T02:29:38Z [Term] id: FYPO:0000450 name: decreased protein localization to centromere def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the centromere of a chromosome is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to centromere" EXACT [PomBase:mah] synonym: "decreased protein localisation to chromosome, centromeric region" EXACT [GO:0071459, PomBase:mah] synonym: "decreased protein localization to centromere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to centromere during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein localization to chromosome, centric region" EXACT [GO:0071459, PomBase:mah] synonym: "decreased protein localization to chromosome, centromeric region" EXACT [GO:0071459, PomBase:mah] synonym: "reduced protein localization to centromere" EXACT [PomBase:mah] is_a: FYPO:0000449 ! abnormal protein localization to centromere is_a: FYPO:0002839 ! decreased protein localization to chromosome intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071459 ! protein localization to chromosome, centromeric region relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071459 ! protein localization to chromosome, centromeric region created_by: midori creation_date: 2011-08-12T02:33:53Z [Term] id: FYPO:0000451 name: increased protein localization to centromere def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the centromere of a chromosome is increased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to centromere" EXACT [PomBase:mah] synonym: "increased protein localisation to chromosome, centromeric region" EXACT [GO:0071459, PomBase:mah] synonym: "increased protein localization to centromere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein localization to centromere during vegetative growth" EXACT [PomBase:mah] synonym: "increased protein localization to chromosome, centric region" EXACT [GO:0071459, PomBase:mah] synonym: "increased protein localization to chromosome, centromeric region" EXACT [GO:0071459, PomBase:mah] is_a: FYPO:0000449 ! abnormal protein localization to centromere is_a: FYPO:0002840 ! increased protein localization to chromosome intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071459 ! protein localization to chromosome, centromeric region relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071459 ! protein localization to chromosome, centromeric region created_by: midori creation_date: 2011-08-12T02:34:10Z [Term] id: FYPO:0000452 name: abnormal protein localization to chromatin during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to chromatin is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found associated with chromatin and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to chromatin during vegetative growth" EXACT [GO:0071168, PomBase:mah] synonym: "abnormal protein localization to chromatin during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001679 ! abnormal protein localization to chromatin is_a: FYPO:0002838 ! abnormal protein localization to chromosome intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0071168 ! protein localization to chromatin intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0071168 ! protein localization to chromatin relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-12T02:35:06Z [Term] id: FYPO:0000453 name: DNA content decreased during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the total amount of DNA in a cell is lower than normal." [PomBase:mah] synonym: "decreased DNA content during vegetative growth" EXACT [PomBase:mah] synonym: "decreased DNA level during vegetative growth" EXACT [PomBase:mah] synonym: "DNA content decreased during mitotic cell cycle" RELATED [PomBase:mah] synonym: "DNA content reduced during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001329 ! decreased level of substance in cell during vegetative growth is_a: FYPO:0004321 ! altered DNA level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:16991 ! deoxyribonucleic acid relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:16991 ! deoxyribonucleic acid created_by: midori creation_date: 2011-08-12T02:37:29Z [Term] id: FYPO:0000454 name: inviable mixed population including long and short cells def: "A mixed population phenotype in which a microcolony forms, all cells in the population are inviable, and some cells are longer and other cells smaller than normal." [PomBase:mah] comment: This term was made obsolete because a "mixed population" observation would be better represented as two or more separate phenotype annotations, each with penetrance specified. synonym: "essential; mixed population including long and short cells" RELATED [PomBase:mah] synonym: "inviable mixed population including long and short vegetative cells" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2011-08-12T02:39:05Z [Term] id: FYPO:0000455 name: increased number of double-strand break sites during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the number of sites of double-strand breaks in DNA is greater than normal." [PomBase:mah] comment: Because Rad22 often accumulates at double-strand breaks, consider also annotating to 'increased number of Rad22 foci' (FYPO:0000972). synonym: "accumulation of DNA damage foci during vegetative growth" RELATED [PomBase:mah] synonym: "accumulation of double-strand break sites during vegetative growth" EXACT [PomBase:mah] synonym: "increased number of DNA damage foci during vegetative growth" RELATED [PomBase:mah] synonym: "increased number of double-strand break sites during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001321 ! cellular physical quality phenotype during vegetative growth is_a: FYPO:0003543 ! increased number of double-strand break sites is_a: FYPO:0003547 ! increased DNA damage during vegetative growth intersection_of: PATO:0002002 ! has extra parts of type intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0035861 ! site of double-strand break relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0035861 ! site of double-strand break created_by: midori creation_date: 2011-08-12T02:44:35Z [Term] id: FYPO:0000456 name: abnormal histone acetylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone acetylation is abnormal." [PomBase:mah] synonym: "abnormal histone acetylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal histone acetylation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000330 ! abnormal histone modification is_a: FYPO:0002392 ! abnormal protein acetylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0016573 ! histone acetylation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0016573 ! histone acetylation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-12T02:55:54Z [Term] id: FYPO:0000457 name: abnormal histone methylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone methylation is abnormal. All histone methylation may be affected, or methylation of specific sites on specific histones may be altered." [PomBase:mah] synonym: "abnormal histone methylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal histone methylation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000330 ! abnormal histone modification intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0016571 ! histone methylation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0016571 ! histone methylation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-12T02:56:38Z [Term] id: FYPO:0000458 name: abnormal histone H3-K9 methylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which methylation of lysine at position 9 of histone H3 is abnormal." [PomBase:mah] synonym: "abnormal histone H3 K9 methylation" EXACT [GO:0051567, PomBase:mah] synonym: "abnormal histone H3-K9 methylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal histone H3-K9 methylation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal histone H3K9me" EXACT [GO:0051567, PomBase:mah] synonym: "abnormal histone lysine H3 K9 methylation" EXACT [GO:0051567, PomBase:mah] is_a: FYPO:0000457 ! abnormal histone methylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0051567 ! histone H3-K9 methylation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0051567 ! histone H3-K9 methylation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-12T02:57:59Z [Term] id: FYPO:0000459 name: abnormal mitotic centromeric sister chromatid cohesion def: "A cellular process phenotype in which cohesion between centromeres of sister chromatids is abnormal during mitosis." [PomBase:mah] synonym: "abnormal centromeric sister chromatid cohesion during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal mitotic sister chromatid cohesion, centromeric" EXACT [GO:0071962, PomBase:mah] synonym: "abnormal sister chromatid cohesion at centromere during mitosis" EXACT [PomBase:mah] is_a: FYPO:0000641 ! abnormal chromosome organization is_a: FYPO:0001353 ! abnormal cellular component organization during vegetative growth is_a: FYPO:0002737 ! abnormal mitotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0071962 ! mitotic sister chromatid cohesion, centromeric intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0071962 ! mitotic sister chromatid cohesion, centromeric relationship: part_of FYPO:0000141 ! abnormal mitotic sister chromatid segregation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-12T03:12:26Z [Term] id: FYPO:0000460 name: decreased mitotic centromeric sister chromatid cohesion def: "A cellular process phenotype in which cohesion between centromeres of sister chromatids is decreased during mitosis." [PomBase:mah] synonym: "decreased centromeric sister chromatid cohesion during vegetative growth" EXACT [PomBase:mah] synonym: "decreased mitotic sister chromatid cohesion, centromeric" EXACT [GO:0071962, PomBase:mah] synonym: "decreased sister chromatid cohesion at centromere during mitosis" EXACT [PomBase:mah] synonym: "reduced mitotic centromeric sister chromatid cohesion" EXACT [PomBase:mah] is_a: FYPO:0000459 ! abnormal mitotic centromeric sister chromatid cohesion is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071962 ! mitotic sister chromatid cohesion, centromeric relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071962 ! mitotic sister chromatid cohesion, centromeric created_by: midori creation_date: 2011-08-12T03:14:23Z [Term] id: FYPO:0000461 name: flocculation abolished def: "A cellular process phenotype in which flocculation does not occur." [PomBase:mah] synonym: "absent flocculation" EXACT [PomBase:mah] synonym: "flocculation: absent" EXACT [SGD:phenotype_annotation] is_obsolete: true created_by: midori creation_date: 2011-08-12T04:05:34Z [Term] id: FYPO:0000463 name: normal flocculation def: "A cellular process phenotype in which flocculation is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "flocculation: normal" EXACT [SGD:phenotype_annotation] is_obsolete: true created_by: midori creation_date: 2011-08-12T04:05:34Z [Term] id: FYPO:0000464 name: decreased intracellular transport def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of intracellular transport is decreased." [PomBase:mah] synonym: "decreased intracellular transport during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased intracellular transport during vegetative growth" EXACT [PomBase:mah] synonym: "intracellular transport: decreased" EXACT [SGD:phenotype_annotation] synonym: "reduced intracellular transport" EXACT [PomBase:mah] is_a: FYPO:0001336 ! transport phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0001720 ! abnormal transport is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0046907 ! intracellular transport relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0046907 ! intracellular transport created_by: midori creation_date: 2011-08-12T04:05:34Z [Term] id: FYPO:0000466 name: decreased invasive growth def: "A cellular process phenotype in which the occurrence of invasive growth is decreased." [PomBase:mah] comment: This term was made obsolete because it is not required to describe fission yeast. synonym: "invasive growth: decreased" EXACT [SGD:phenotype_annotation] synonym: "reduced invasive growth" EXACT [PomBase:mah] is_obsolete: true consider: FYPO:0000552 created_by: midori creation_date: 2011-08-12T04:05:34Z [Term] id: FYPO:0000467 name: increased invasive growth def: "A cellular process phenotype in which the occurrence of invasive growth is increased." [PomBase:mah] comment: This term was made obsolete because it is not required to describe fission yeast. synonym: "invasive growth: increased" EXACT [SGD:phenotype_annotation] is_obsolete: true consider: FYPO:0000553 created_by: midori creation_date: 2011-08-12T04:05:34Z [Term] id: FYPO:0000468 name: abnormal mating type switching def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mating type switching is abnormal." [PomBase:mah] synonym: "abnormal mating type switching during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal mating type switching during vegetative growth" EXACT [PomBase:mah] synonym: "mating type switching: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000679 ! developmental process phenotype is_a: FYPO:0001346 ! DNA metabolism phenotype during vegetative growth is_a: FYPO:0001363 ! abnormal metabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0007533 ! mating type switching intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0007533 ! mating type switching relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-12T04:05:34Z [Term] id: FYPO:0000469 name: abolished mating type switching def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mating type switching does not occur." [PomBase:mah] synonym: "abolished mating type switching during mitotic cell cycle" RELATED [PomBase:mah] synonym: "absent mating type switching" EXACT [PomBase:mah] synonym: "mating type switching abolished" EXACT [PomBase:mah] synonym: "mating type switching abolished during vegetative growth" EXACT [PomBase:mah] synonym: "mating type switching: absent" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000468 ! abnormal mating type switching is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0007533 ! mating type switching relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0007533 ! mating type switching created_by: midori creation_date: 2011-08-12T04:05:34Z [Term] id: FYPO:0000470 name: decreased mating type switching def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of mating type switching is decreased." [PomBase:mah] synonym: "decreased mating type switching during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased mating type switching during vegetative growth" EXACT [PomBase:mah] synonym: "mating type switching: decreased" EXACT [SGD:phenotype_annotation] synonym: "reduced mating type switching" EXACT [PomBase:mah] is_a: FYPO:0000468 ! abnormal mating type switching is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0007533 ! mating type switching relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0007533 ! mating type switching created_by: midori creation_date: 2011-08-12T04:05:34Z [Term] id: FYPO:0000471 name: increased mating type switching def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of mating type switching is increased." [PomBase:mah] synonym: "increased mating type switching during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased mating type switching during vegetative growth" EXACT [PomBase:mah] synonym: "mating type switching: increased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000468 ! abnormal mating type switching is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0007533 ! mating type switching relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0007533 ! mating type switching created_by: midori creation_date: 2011-08-12T04:05:34Z [Term] id: FYPO:0000472 name: normal mating type switching def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mating type switching is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "mating type switching: normal" EXACT [SGD:phenotype_annotation] synonym: "normal mating type switching during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal mating type switching during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001319 ! normal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0007533 ! mating type switching intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0007533 ! mating type switching relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-08-12T04:05:34Z [Term] id: FYPO:0000473 name: increased mitotic recombination def: "A cellular process phenotype in which the occurrence of mitotic recombination is increased." [PomBase:mah] synonym: "increased mitotic recombination during vegetative growth" EXACT [PomBase:mah] synonym: "mitotic recombination: increased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000481 ! abnormal mitotic recombination is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006312 ! mitotic recombination relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006312 ! mitotic recombination created_by: midori creation_date: 2011-08-15T10:19:32Z [Term] id: FYPO:0000474 name: abolished meiosis def: "A cellular process phenotype in which one or both meiotic nuclear division(s) does not occur." [PomBase:mah] synonym: "abolished meiotic nuclear division" EXACT [GO:0007126] synonym: "absent meiosis" EXACT [PomBase:mah] synonym: "meiosis abolished" EXACT [PomBase:mah] synonym: "meiosis: absent" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000051 ! abnormal meiosis is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0007126 ! meiotic nuclear division relationship: towards GO:0007126 ! meiotic nuclear division created_by: midori creation_date: 2011-08-15T10:19:32Z [Term] id: FYPO:0000475 name: abnormally arrested meiosis def: "A cellular process phenotype in which one or both meiotic nuclear division(s) is arrested under conditions where arrest does not normally occur." [PomBase:mah] synonym: "meiosis: arrested" EXACT [SGD:phenotype_annotation] synonym: "meiotic cell cycle arrest in M phase" EXACT [PomBase:mah] is_a: FYPO:0002224 ! abnormally arrested meiotic cell cycle intersection_of: PATO:0001561 ! having extra processual parts intersection_of: during GO:0007126 ! meiotic nuclear division intersection_of: inheres_in GO:0007050 ! cell cycle arrest relationship: during GO:0007126 ! meiotic nuclear division relationship: inheres_in GO:0007050 ! cell cycle arrest created_by: midori creation_date: 2011-08-15T10:19:32Z [Term] id: FYPO:0000476 name: decreased meiosis def: "A cellular process phenotype in which the occurrence of one or both meiotic nuclear division(s) is decreased." [PomBase:mah] synonym: "decreased meiotic nuclear division" EXACT [GO:0007126] synonym: "meiosis: decreased" EXACT [SGD:phenotype_annotation] synonym: "reduced meiosis" EXACT [PomBase:mah] is_a: FYPO:0000051 ! abnormal meiosis is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0007126 ! meiotic nuclear division relationship: inheres_in GO:0007126 ! meiotic nuclear division created_by: midori creation_date: 2011-08-15T10:19:32Z [Term] id: FYPO:0000477 name: delayed meiosis def: "A cellular process phenotype in which one or both meiotic nuclear division(s) begins later than normal." [PomBase:mah] synonym: "delayed meiotic nuclear division" EXACT [GO:0007126] synonym: "meiosis: delayed" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000051 ! abnormal meiosis is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: inheres_in GO:0007126 ! meiotic nuclear division relationship: inheres_in GO:0007126 ! meiotic nuclear division created_by: midori creation_date: 2011-08-15T10:19:32Z [Term] id: FYPO:0000478 name: normal meiosis def: "A cellular process phenotype in which the meiotic nuclear divisions are normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "meiosis: normal" EXACT [SGD:phenotype_annotation] synonym: "normal meiotic nuclear division" EXACT [GO:0007126] is_a: FYPO:0000627 ! normal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0007126 ! meiotic nuclear division intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0007126 ! meiotic nuclear division relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-08-15T10:19:32Z [Term] id: FYPO:0000479 name: premature meiosis def: "A cellular process phenotype in which one or both meiotic nuclear division(s) occurs prematurely." [PomBase:mah] synonym: "advanced meiosis" EXACT [PomBase:mah] synonym: "meiosis: premature" EXACT [SGD:phenotype_annotation] synonym: "premature meiotic nuclear division" EXACT [GO:0007126] is_a: FYPO:0000051 ! abnormal meiosis is_a: PATO:0000694 ! premature intersection_of: PATO:0000694 ! premature intersection_of: inheres_in GO:0007126 ! meiotic nuclear division relationship: inheres_in GO:0007126 ! meiotic nuclear division created_by: midori creation_date: 2011-08-15T10:19:32Z [Term] id: FYPO:0000481 name: abnormal mitotic recombination def: "A cellular process phenotype in which mitotic recombination is abnormal." [PomBase:mah] synonym: "abnormal mitotic recombination during vegetative growth" EXACT [PomBase:mah] synonym: "mitotic recombination: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001345 ! abnormal DNA recombination during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006312 ! mitotic recombination intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006312 ! mitotic recombination relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-15T10:19:32Z [Term] id: FYPO:0000482 name: decreased mitotic recombination def: "A cellular process phenotype in which the occurrence of mitotic recombination is decreased." [PomBase:mah] synonym: "decreased mitotic recombination during vegetative growth" EXACT [PomBase:mah] synonym: "mitotic recombination: decreased" EXACT [SGD:phenotype_annotation] synonym: "reduced mitotic recombination" EXACT [PomBase:mah] is_a: FYPO:0000481 ! abnormal mitotic recombination is_a: FYPO:0002340 ! decreased DNA recombination during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006312 ! mitotic recombination relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006312 ! mitotic recombination created_by: midori creation_date: 2011-08-15T10:19:32Z [Term] id: FYPO:0000483 name: increased rate of mitotic recombination def: "A cellular process phenotype in which the rate, or speed, of mitotic recombination is increased." [PomBase:mah] synonym: "increased rate of mitotic recombination during vegetative growth" EXACT [PomBase:mah] synonym: "mitotic recombination: increased rate" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000481 ! abnormal mitotic recombination is_a: PATO:0000912 ! increased rate intersection_of: PATO:0000912 ! increased rate intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006312 ! mitotic recombination relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006312 ! mitotic recombination created_by: midori creation_date: 2011-08-15T10:19:32Z [Term] id: FYPO:0000484 name: abolished meiotic recombination def: "A cellular process phenotype in which reciprocal meiotic recombination does not occur." [PomBase:mah] synonym: "absent meiotic recombination" EXACT [PomBase:mah] synonym: "meiotic recombination abolished" EXACT [PomBase:mah] synonym: "meiotic recombination: absent" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000008 ! abnormal meiotic recombination is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0007131 ! reciprocal meiotic recombination relationship: towards GO:0007131 ! reciprocal meiotic recombination created_by: midori creation_date: 2011-08-15T10:19:32Z [Term] id: FYPO:0000485 name: decreased meiotic recombination def: "A cellular process phenotype in which the occurrence of reciprocal meiotic recombination is decreased." [PomBase:mah] synonym: "meiotic recombination: decreased" EXACT [SGD:phenotype_annotation] synonym: "reduced meiotic recombination" EXACT [PomBase:mah] is_a: FYPO:0000008 ! abnormal meiotic recombination is_a: FYPO:0002712 ! decreased DNA recombination intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0007131 ! reciprocal meiotic recombination relationship: inheres_in GO:0007131 ! reciprocal meiotic recombination created_by: midori creation_date: 2011-08-15T10:19:32Z [Term] id: FYPO:0000486 name: delayed meiotic recombination def: "A cellular process phenotype in which reciprocal meiotic recombination begins later than normal." [PomBase:mah] synonym: "meiotic recombination: delayed" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000008 ! abnormal meiotic recombination is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: inheres_in GO:0007131 ! reciprocal meiotic recombination relationship: inheres_in GO:0007131 ! reciprocal meiotic recombination created_by: midori creation_date: 2011-08-15T10:19:32Z [Term] id: FYPO:0000487 name: increased meiotic recombination def: "A cellular process phenotype in which the occurrence of reciprocal meiotic recombination is increased." [PomBase:mah] synonym: "meiotic recombination: increased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000008 ! abnormal meiotic recombination is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0007131 ! reciprocal meiotic recombination relationship: inheres_in GO:0007131 ! reciprocal meiotic recombination created_by: midori creation_date: 2011-08-15T10:19:32Z [Term] id: FYPO:0000488 name: normal meiotic recombination def: "A cellular process phenotype in which reciprocal meiotic recombination is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "meiotic recombination: normal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0002496 ! normal metabolic process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0007131 ! reciprocal meiotic recombination intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0007131 ! reciprocal meiotic recombination relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-08-15T10:19:32Z [Term] id: FYPO:0000489 name: abnormal mitochondrial distribution def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitochondrion distribution is abnormal." [PomBase:mah] synonym: "abnormal mitochondrial distribution during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal mitochondrial distribution during vegetative growth" EXACT [PomBase:mah] synonym: "mitochondrial distribution: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000809 ! abnormal mitochondrion organization is_a: FYPO:0001337 ! localization phenotype during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0048311 ! mitochondrion distribution intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0048311 ! mitochondrion distribution relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-15T10:19:32Z [Term] id: FYPO:0000490 name: abnormal mitochondrial genome maintenance def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitochondrial genome maintenance is abnormal." [PomBase:mah] synonym: "abnormal mitochondrial genome maintenance during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal mitochondrial genome maintenance during vegetative growth" EXACT [PomBase:mah] synonym: "mitochondrial genome maintenance: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000809 ! abnormal mitochondrion organization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000002 ! mitochondrial genome maintenance intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000002 ! mitochondrial genome maintenance relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-15T10:19:32Z [Term] id: FYPO:0000491 name: abolished mitochondrial genome maintenance def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitochondrial genome maintenance does not occur." [PomBase:mah] synonym: "abolished mitochondrial genome maintenance during mitotic cell cycle" RELATED [PomBase:mah] synonym: "absent mitochondrial genome maintenance" EXACT [PomBase:mah] synonym: "mitochondrial genome maintenance abolished" EXACT [PomBase:mah] synonym: "mitochondrial genome maintenance abolished during vegetative growth" EXACT [PomBase:mah] synonym: "mitochondrial genome maintenance: absent" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000490 ! abnormal mitochondrial genome maintenance is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0000002 ! mitochondrial genome maintenance relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0000002 ! mitochondrial genome maintenance created_by: midori creation_date: 2011-08-15T10:19:32Z [Term] id: FYPO:0000492 name: decreased mitochondrial genome maintenance def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of mitochondrial genome maintenance is decreased." [PomBase:mah] synonym: "decreased mitochondrial genome maintenance during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased mitochondrial genome maintenance during vegetative growth" EXACT [PomBase:mah] synonym: "mitochondrial genome maintenance: decreased" EXACT [SGD:phenotype_annotation] synonym: "reduced mitochondrial genome maintenance" EXACT [PomBase:mah] is_a: FYPO:0000490 ! abnormal mitochondrial genome maintenance is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000002 ! mitochondrial genome maintenance relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000002 ! mitochondrial genome maintenance created_by: midori creation_date: 2011-08-15T10:19:32Z [Term] id: FYPO:0000493 name: increased mitochondrial genome maintenance def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of mitochondrial genome maintenance is increased." [PomBase:mah] synonym: "increased mitochondrial genome maintenance during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased mitochondrial genome maintenance during vegetative growth" EXACT [PomBase:mah] synonym: "mitochondrial genome maintenance: increased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000490 ! abnormal mitochondrial genome maintenance is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000002 ! mitochondrial genome maintenance relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000002 ! mitochondrial genome maintenance created_by: midori creation_date: 2011-08-15T10:19:32Z [Term] id: FYPO:0000494 name: normal mitochondrial genome maintenance def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitochondrial genome maintenance is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "mitochondrial genome maintenance: normal" EXACT [SGD:phenotype_annotation] synonym: "normal mitochondrial genome maintenance during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal mitochondrial genome maintenance during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001319 ! normal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000002 ! mitochondrial genome maintenance intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000002 ! mitochondrial genome maintenance relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-08-15T10:19:32Z [Term] id: FYPO:0000495 name: abnormal mitochondrial transport def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitochondrial transport is abnormal." [PomBase:mah] synonym: "abnormal mitochondrial transport during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal mitochondrial transport during vegetative growth" EXACT [PomBase:mah] synonym: "mitochondrial transport: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001336 ! transport phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0001720 ! abnormal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006839 ! mitochondrial transport intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006839 ! mitochondrial transport relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-15T10:19:32Z [Term] id: FYPO:0000496 name: decreased mitochondrial transport def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of mitochondrial transport is decreased." [PomBase:mah] synonym: "decreased mitochondrial transport during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased mitochondrial transport during vegetative growth" EXACT [PomBase:mah] synonym: "mitochondrial transport: decreased" EXACT [SGD:phenotype_annotation] synonym: "reduced mitochondrial transport" EXACT [PomBase:mah] is_a: FYPO:0000464 ! decreased intracellular transport is_a: FYPO:0000495 ! abnormal mitochondrial transport intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006839 ! mitochondrial transport relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006839 ! mitochondrial transport created_by: midori creation_date: 2011-08-15T10:19:32Z [Term] id: FYPO:0000497 name: decreased rate of mitochondrial transport def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the rate, or speed, of mitochondrial transport is decreased." [PomBase:mah] synonym: "decreased rate of mitochondrial transport during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased rate of mitochondrial transport during vegetative growth" EXACT [PomBase:mah] synonym: "mitochondrial transport: decreased rate" EXACT [SGD:phenotype_annotation] synonym: "reduced rate of mitochondrial transport" EXACT [PomBase:mah] is_a: FYPO:0000495 ! abnormal mitochondrial transport is_a: PATO:0000911 ! decreased rate intersection_of: PATO:0000911 ! decreased rate intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006839 ! mitochondrial transport relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006839 ! mitochondrial transport created_by: midori creation_date: 2011-08-15T10:19:32Z [Term] id: FYPO:0000498 name: normal mitochondrial transport def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitochondrial transport is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "mitochondrial transport: normal" EXACT [SGD:phenotype_annotation] synonym: "normal mitochondrial transport during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal mitochondrial transport during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001071 ! normal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006839 ! mitochondrial transport intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006839 ! mitochondrial transport relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-08-15T10:19:32Z [Term] id: FYPO:0000499 name: abolished mitophagy def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitophagy does not occur." [PomBase:mah] synonym: "absent mitophagy" EXACT [PomBase:mah] synonym: "mitophagy abolished" EXACT [PomBase:mah] synonym: "mitophagy: absent" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000380 ! abolished autophagy intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0000422 ! mitophagy relationship: towards GO:0000422 ! mitophagy created_by: midori creation_date: 2011-08-15T10:19:32Z [Term] id: FYPO:0000500 name: decreased mitophagy def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of mitophagy is decreased." [PomBase:mah] synonym: "mitophagy: decreased" EXACT [SGD:phenotype_annotation] synonym: "reduced mitophagy" EXACT [PomBase:mah] is_a: FYPO:0000381 ! decreased autophagy intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0000422 ! mitophagy relationship: inheres_in GO:0000422 ! mitophagy created_by: midori creation_date: 2011-08-15T10:19:32Z [Term] id: FYPO:0000501 name: increased mitophagy def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of mitophagy is increased." [PomBase:mah] synonym: "mitophagy: increased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000384 ! increased autophagy intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0000422 ! mitophagy relationship: inheres_in GO:0000422 ! mitophagy created_by: midori creation_date: 2011-08-15T10:19:32Z [Term] id: FYPO:0000502 name: abnormally arrested mitotic cell cycle progression def: "A cellular process phenotype in which progression through the mitotic cell cycle is arrested under conditions where arrest does not normally occur." [PomBase:mah] synonym: "abnormal mitotic cell cycle arrest" RELATED [PomBase:mah] synonym: "abnormally arrested mitotic cell cycle" EXACT [PomBase:mah] synonym: "abnormally arrested mitotic cell cycle progression during vegetative growth" EXACT [PomBase:mah] synonym: "mitotic cell cycle abnormally arrested" EXACT [PomBase:mah] synonym: "mitotic cell cycle: arrested" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000148 ! abnormal regulation of mitotic cell cycle is_a: FYPO:0000407 ! abnormally arrested cell cycle progression intersection_of: PATO:0001561 ! having extra processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0071850 ! mitotic cell cycle arrest relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0071850 ! mitotic cell cycle arrest created_by: midori creation_date: 2011-08-15T10:19:32Z [Term] id: FYPO:0000503 name: normal mitotic recombination def: "A cellular process phenotype in which mitotic recombination is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "mitotic recombination: normal" EXACT [SGD:phenotype_annotation] synonym: "normal mitotic recombination during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000859 ! normal metabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006312 ! mitotic recombination intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006312 ! mitotic recombination relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000504 name: decreased necrotic cell death def: "A cellular process phenotype in which the occurrence of necrotic cell death is decreased. Necrotic cell death is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents." [GO:0070265, PomBase:mah] comment: This term was made obsolete because necrotic cell death has not been observed in fission yeast. synonym: "necrotic cell death: decreased" EXACT [SGD:phenotype_annotation] synonym: "reduced necrotic cell death" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000505 name: increased necrotic cell death def: "A cellular process phenotype in which the occurrence of necrotic cell death is increased. Necrotic cell death is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents." [GO:0070265, PomBase:mah] comment: This term was made obsolete because necrotic cell death has not been observed in fission yeast. synonym: "necrotic cell death: increased" EXACT [SGD:phenotype_annotation] is_obsolete: true created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000506 name: abnormal nuclear export def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which nuclear export is abnormal. Nuclear export is the directed movement of any substance out of the nucleus; export of all substances or a specific substance may be affected." [PomBase:mah] synonym: "abnormal nuclear export during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal nuclear export during vegetative growth" EXACT [PomBase:mah] synonym: "nuclear export: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000518 ! abnormal nuclear transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0051168 ! nuclear export intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0051168 ! nuclear export relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000507 name: abolished nuclear export def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which nuclear export does not occur. Nuclear export is the directed movement of any substance out of the nucleus; export of all substances or a specific substance may be affected." [PomBase:mah] synonym: "abolished nuclear export during mitotic cell cycle" RELATED [PomBase:mah] synonym: "absent nuclear export" EXACT [PomBase:mah] synonym: "nuclear export abolished" EXACT [PomBase:mah] synonym: "nuclear export abolished during vegetative growth" EXACT [PomBase:mah] synonym: "nuclear export: absent" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000506 ! abnormal nuclear export is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0051168 ! nuclear export relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0051168 ! nuclear export created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000508 name: decreased nuclear export def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of nuclear export is decreased. Nuclear export is the directed movement of any substance out of the nucleus; export of all substances or a specific substance may be affected." [PomBase:mah] synonym: "decreased nuclear export during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased nuclear export during vegetative growth" EXACT [PomBase:mah] synonym: "nuclear export: decreased" EXACT [SGD:phenotype_annotation] synonym: "reduced nuclear export" EXACT [PomBase:mah] is_a: FYPO:0000464 ! decreased intracellular transport is_a: FYPO:0000506 ! abnormal nuclear export intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051168 ! nuclear export relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051168 ! nuclear export created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000509 name: normal nuclear export def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which nuclear export is normal (i.e. indistinguishable from wild type). Nuclear export is the directed movement of any substance out of the nucleus; export of all substances or a specific substance may be affected." [PomBase:mah] synonym: "normal nuclear export during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal nuclear export during vegetative growth" EXACT [PomBase:mah] synonym: "nuclear export: normal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001071 ! normal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051168 ! nuclear export intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051168 ! nuclear export relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000510 name: abnormal nuclear fusion during mating def: "A cellular process phenotype in which karyogamy involved in conjugation with cellular fusion is abnormal." [PomBase:mah] synonym: "abnormal karyogamy" EXACT [PomBase:mah] synonym: "abnormal karyogamy involved in conjugation with cellular fusion" EXACT [PomBase:mah] synonym: "nuclear fusion during mating: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000335 ! abnormal cellular component organization intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0000742 ! karyogamy involved in conjugation with cellular fusion intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0000742 ! karyogamy involved in conjugation with cellular fusion relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000511 name: abolished nuclear fusion during mating def: "A cellular process phenotype in which karyogamy involved in conjugation with cellular fusion does not occur." [PomBase:mah] synonym: "absent nuclear fusion during mating" EXACT [PomBase:mah] synonym: "karyogamy abolished" EXACT [PomBase:mah] synonym: "karyogamy involved in conjugation with cellular fusion abolished" EXACT [PomBase:mah] synonym: "nuclear fusion during mating abolished" EXACT [PomBase:mah] synonym: "nuclear fusion during mating: absent" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000510 ! abnormal nuclear fusion during mating is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0000742 ! karyogamy involved in conjugation with cellular fusion relationship: towards GO:0000742 ! karyogamy involved in conjugation with cellular fusion created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000512 name: decreased nuclear fusion during mating def: "A cellular process phenotype in which the occurrence of karyogamy involved in conjugation with cellular fusion is decreased." [PomBase:mah] synonym: "decreased karyogamy" EXACT [PomBase:mah] synonym: "decreased karyogamy involved in conjugation with cellular fusion" EXACT [PomBase:mah] synonym: "nuclear fusion during mating: decreased" EXACT [SGD:phenotype_annotation] synonym: "reduced nuclear fusion during mating" EXACT [PomBase:mah] is_a: FYPO:0000510 ! abnormal nuclear fusion during mating is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0000742 ! karyogamy involved in conjugation with cellular fusion relationship: inheres_in GO:0000742 ! karyogamy involved in conjugation with cellular fusion created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000513 name: delayed nuclear fusion during mating def: "A cellular process phenotype in which karyogamy involved in conjugation with cellular fusion begins later than normal." [PomBase:mah] synonym: "delayed karyogamy" EXACT [PomBase:mah] synonym: "delayed karyogamy involved in conjugation with cellular fusion" EXACT [PomBase:mah] synonym: "nuclear fusion during mating: delayed" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000510 ! abnormal nuclear fusion during mating is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: inheres_in GO:0000742 ! karyogamy involved in conjugation with cellular fusion relationship: inheres_in GO:0000742 ! karyogamy involved in conjugation with cellular fusion created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000514 name: abolished nuclear import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which nuclear import does not occur. Nuclear import is the directed movement of any substance into the nucleus; import of all substances or a specific substance may be affected." [PomBase:mah] synonym: "abolished nuclear import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "absent nuclear import" EXACT [PomBase:mah] synonym: "nuclear import abolished" EXACT [PomBase:mah] synonym: "nuclear import abolished during vegetative growth" EXACT [PomBase:mah] synonym: "nuclear import: absent" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001217 ! abnormal nuclear import is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0051170 ! nuclear import relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0051170 ! nuclear import created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000515 name: decreased nuclear import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of nuclear import is decreased. Nuclear import is the directed movement of any substance into the nucleus; import of all substances or a specific substance may be affected." [PomBase:mah] synonym: "decreased nuclear import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased nuclear import during vegetative growth" EXACT [PomBase:mah] synonym: "nuclear import: decreased" EXACT [SGD:phenotype_annotation] synonym: "reduced nuclear import" EXACT [PomBase:mah] is_a: FYPO:0000464 ! decreased intracellular transport is_a: FYPO:0001217 ! abnormal nuclear import intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051170 ! nuclear import relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051170 ! nuclear import created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000516 name: normal nuclear import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which nuclear import is normal (i.e. indistinguishable from wild type). Nuclear import is the directed movement of any substance into the nucleus; import of all substances or a specific substance may be affected." [PomBase:mah] synonym: "normal nuclear import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal nuclear import during vegetative growth" EXACT [PomBase:mah] synonym: "nuclear import: normal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001071 ! normal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051170 ! nuclear import intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051170 ! nuclear import relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000517 name: abnormal nucleus localization def: "A cellular process phenotype in which nucleus localization is abnormal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "abnormal nuclear localization" EXACT [PomBase:mah] synonym: "abnormal nucleus localisation" EXACT [PomBase:mah] is_a: FYPO:0000138 ! localization phenotype is_a: FYPO:0000628 ! abnormal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0051647 ! nucleus localization intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0051647 ! nucleus localization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000518 name: abnormal nuclear transport def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which nuclear transport is abnormal." [PomBase:mah] synonym: "abnormal nuclear transport during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal nuclear transport during vegetative growth" EXACT [PomBase:mah] synonym: "nuclear transport: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001336 ! transport phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0001720 ! abnormal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0051169 ! nuclear transport intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0051169 ! nuclear transport relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000519 name: decreased oxidative phosphorylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of oxidative phosphorylation is decreased." [PomBase:mah] synonym: "decreased oxidative phosphorylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased oxidative phosphorylation during vegetative growth" EXACT [PomBase:mah] synonym: "oxidative phosphorylation: decreased" EXACT [SGD:phenotype_annotation] synonym: "reduced oxidative phosphorylation" EXACT [PomBase:mah] is_a: FYPO:0001348 ! cellular metabolism phenotype during vegetative growth is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006119 ! oxidative phosphorylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006119 ! oxidative phosphorylation created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000520 name: increased oxidative phosphorylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of oxidative phosphorylation is increased." [PomBase:mah] synonym: "increased oxidative phosphorylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased oxidative phosphorylation during vegetative growth" EXACT [PomBase:mah] synonym: "oxidative phosphorylation: increased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001348 ! cellular metabolism phenotype during vegetative growth is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006119 ! oxidative phosphorylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006119 ! oxidative phosphorylation created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000521 name: abnormal peroxisome localization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which peroxisome localization is abnormal." [PomBase:mah] synonym: "abnormal peroxisomal distribution" EXACT [PomBase:mah] synonym: "abnormal peroxisome localisation" EXACT [PomBase:mah] synonym: "abnormal peroxisome localization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal peroxisome localization during vegetative growth" EXACT [PomBase:mah] synonym: "peroxisomal distribution: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001337 ! localization phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0060151 ! peroxisome localization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0060151 ! peroxisome localization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000522 name: abnormal peroxisomal transport def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which peroxisomal transport is abnormal." [PomBase:mah] synonym: "abnormal peroxisomal transport during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal peroxisomal transport during vegetative growth" EXACT [PomBase:mah] synonym: "peroxisomal transport: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001336 ! transport phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0001720 ! abnormal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0043574 ! peroxisomal transport intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0043574 ! peroxisomal transport relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000523 name: abolished peroxisomal transport def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which peroxisomal transport does not occur." [PomBase:mah] synonym: "abolished peroxisomal transport during mitotic cell cycle" RELATED [PomBase:mah] synonym: "absent peroxisomal transport" EXACT [PomBase:mah] synonym: "peroxisomal transport abolished" EXACT [PomBase:mah] synonym: "peroxisomal transport abolished during vegetative growth" EXACT [PomBase:mah] synonym: "peroxisomal transport: absent" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000522 ! abnormal peroxisomal transport is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0043574 ! peroxisomal transport relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0043574 ! peroxisomal transport created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000524 name: decreased peroxisomal transport def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of peroxisomal transport is decreased." [PomBase:mah] synonym: "decreased peroxisomal transport during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased peroxisomal transport during vegetative growth" EXACT [PomBase:mah] synonym: "peroxisomal transport: decreased" EXACT [SGD:phenotype_annotation] synonym: "reduced peroxisomal transport" EXACT [PomBase:mah] is_a: FYPO:0000464 ! decreased intracellular transport is_a: FYPO:0000522 ! abnormal peroxisomal transport intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0043574 ! peroxisomal transport relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0043574 ! peroxisomal transport created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000525 name: abolished peroxisome degradation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which pexophagy does not occur." [PomBase:mah] synonym: "absent pexophagy" EXACT [PomBase:mah] synonym: "peroxisome degradation abolished" EXACT [PomBase:mah] synonym: "pexophagy abolished" EXACT [PomBase:mah] synonym: "pexophagy: absent" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000380 ! abolished autophagy intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0030242 ! pexophagy relationship: towards GO:0030242 ! pexophagy created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000526 name: decreased peroxisome degradation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of pexophagy is decreased." [PomBase:mah] synonym: "decreased pexophagy" EXACT [PomBase:mah] synonym: "pexophagy: decreased" EXACT [SGD:phenotype_annotation] synonym: "reduced peroxisome degradation" EXACT [PomBase:mah] is_a: FYPO:0000381 ! decreased autophagy intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0030242 ! pexophagy relationship: inheres_in GO:0030242 ! pexophagy created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000527 name: decreased rate of peroxisome degradation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the rate, or speed, of pexophagy is decreased." [PomBase:mah] synonym: "decreased rate of pexophagy" EXACT [PomBase:mah] synonym: "pexophagy: decreased rate" EXACT [SGD:phenotype_annotation] synonym: "reduced rate of peroxisome degradation" EXACT [PomBase:mah] is_a: FYPO:0000382 ! decreased rate of autophagy intersection_of: PATO:0000911 ! decreased rate intersection_of: inheres_in GO:0030242 ! pexophagy relationship: inheres_in GO:0030242 ! pexophagy created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000528 name: delayed peroxisome degradation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which pexophagy begins later than normal." [PomBase:mah] synonym: "delayed pexophagy" EXACT [PomBase:mah] synonym: "pexophagy: delayed" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000383 ! delayed autophagy intersection_of: PATO:0000502 ! delayed intersection_of: inheres_in GO:0030242 ! pexophagy relationship: inheres_in GO:0030242 ! pexophagy created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000529 name: normal peroxisome degradation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which peroxisome degradation is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal pexophagy" EXACT [PomBase:mah] synonym: "pexophagy: normal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000385 ! normal autophagy intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0030242 ! pexophagy intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0030242 ! pexophagy relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000530 name: abnormal mitotic cell cycle arrest in response to pheromone def: "A cellular process phenotype in which the mitotic cell cycle arrest that normally occurs in response to pheromone is abnormal." [PomBase:mah] synonym: "abnormal pheromone-induced mitotic cell cycle arrest" EXACT [PomBase:mah] synonym: "pheromone-induced cell cycle arrest: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000302 ! abnormal response to pheromone is_a: FYPO:0001026 ! abnormal occurrence of normal mitotic cell cycle arrest intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0000751 ! mitotic cell cycle arrest in response to pheromone intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0000751 ! mitotic cell cycle arrest in response to pheromone relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000531 name: abolished mitotic cell cycle arrest in response to pheromone def: "A cellular process phenotype in which mitotic cell cycle arrest in response to pheromone does not occur." [PomBase:mah] synonym: "absent pheromone-induced mitotic cell cycle arrest" EXACT [PomBase:mah] synonym: "mitotic cell cycle arrest in response to pheromone abolished" EXACT [PomBase:mah] synonym: "pheromone-induced cell cycle arrest: absent" EXACT [SGD:phenotype_annotation] synonym: "pheromone-induced mitotic cell cycle arrest abolished" EXACT [PomBase:mah] is_a: FYPO:0000530 ! abnormal mitotic cell cycle arrest in response to pheromone is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0000751 ! mitotic cell cycle arrest in response to pheromone relationship: towards GO:0000751 ! mitotic cell cycle arrest in response to pheromone created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000532 name: decreased mitotic cell cycle arrest in response to pheromone def: "A cellular process phenotype in which the occurrence of mitotic cell cycle arrest in response to pheromone is decreased." [PomBase:mah] synonym: "decreased pheromone-induced mitotic cell cycle arrest" EXACT [PomBase:mah] synonym: "pheromone-induced cell cycle arrest: decreased" EXACT [SGD:phenotype_annotation] synonym: "reduced mitotic cell cycle arrest in response to pheromone" EXACT [PomBase:mah] is_a: FYPO:0000530 ! abnormal mitotic cell cycle arrest in response to pheromone is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0000751 ! mitotic cell cycle arrest in response to pheromone relationship: inheres_in GO:0000751 ! mitotic cell cycle arrest in response to pheromone created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000533 name: normal mitotic cell cycle arrest in response to pheromone def: "A cellular process phenotype in which mitotic cell cycle arrest in response to pheromone is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal pheromone-induced mitotic cell cycle arrest" EXACT [PomBase:mah] synonym: "pheromone-induced cell cycle arrest: normal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001025 ! normally arrested mitotic cell cycle progression intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0000751 ! mitotic cell cycle arrest in response to pheromone intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0000751 ! mitotic cell cycle arrest in response to pheromone relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000534 name: abnormal spindle pole body localization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which spindle pole body localization is abnormal." [PomBase:mah] synonym: "abnormal position of spindle pole body" EXACT [PomBase:mah] synonym: "abnormal SPB localization" EXACT [PomBase:mah] synonym: "abnormal spindle pole body localisation" EXACT [PomBase:mah] synonym: "abnormal spindle pole body localization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal spindle pole body localization during vegetative growth" EXACT [PomBase:mah] synonym: "position of spindle pole body: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001337 ! localization phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0070631 ! spindle pole body localization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0070631 ! spindle pole body localization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000535 name: normal spindle pole body localization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which spindle pole body localization is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal position of spindle pole body" EXACT [PomBase:mah] synonym: "normal SPB localization" EXACT [PomBase:mah] synonym: "normal spindle pole body localisation" EXACT [PomBase:mah] synonym: "normal spindle pole body localization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal spindle pole body localization during vegetative growth" EXACT [PomBase:mah] synonym: "position of spindle pole body: normal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001319 ! normal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0070631 ! spindle pole body localization intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0070631 ! spindle pole body localization relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000536 name: abnormal protein secretion def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which protein secretion is abnormal." [PomBase:mah] synonym: "abnormal protein secretion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein secretion during vegetative growth" EXACT [PomBase:mah] synonym: "protein secretion: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000540 ! abnormal protein transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0009306 ! protein secretion intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0009306 ! protein secretion relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000537 name: abolished protein secretion def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which protein secretion does not occur." [PomBase:mah] synonym: "abolished protein secretion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "absent protein secretion" EXACT [PomBase:mah] synonym: "protein secretion abolished" EXACT [PomBase:mah] synonym: "protein secretion abolished during vegetative growth" EXACT [PomBase:mah] synonym: "protein secretion: absent" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000536 ! abnormal protein secretion is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0009306 ! protein secretion relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0009306 ! protein secretion created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000538 name: decreased protein secretion def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of protein secretion is decreased." [PomBase:mah] synonym: "decreased protein secretion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein secretion during vegetative growth" EXACT [PomBase:mah] synonym: "protein secretion: decreased" EXACT [SGD:phenotype_annotation] synonym: "reduced protein secretion" EXACT [PomBase:mah] is_a: FYPO:0000536 ! abnormal protein secretion is_a: FYPO:0000541 ! decreased protein transport intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0009306 ! protein secretion relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0009306 ! protein secretion created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000539 name: increased protein secretion def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of protein secretion is increased." [PomBase:mah] synonym: "increased protein secretion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein secretion during vegetative growth" EXACT [PomBase:mah] synonym: "protein secretion: increased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000536 ! abnormal protein secretion is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0009306 ! protein secretion relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0009306 ! protein secretion created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000540 name: abnormal protein transport def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which protein transport is abnormal." [PomBase:mah] synonym: "abnormal protein transport during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein transport during vegetative growth" EXACT [PomBase:mah] synonym: "protein transport: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000443 ! abnormal protein localization during vegetative growth is_a: FYPO:0001336 ! transport phenotype during vegetative growth is_a: FYPO:0001720 ! abnormal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0015031 ! protein transport intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0015031 ! protein transport relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000541 name: decreased protein transport def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of protein transport is decreased." [PomBase:mah] synonym: "decreased protein transport during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein transport during vegetative growth" EXACT [PomBase:mah] synonym: "protein transport: decreased" EXACT [SGD:phenotype_annotation] synonym: "reduced protein transport" EXACT [PomBase:mah] is_a: FYPO:0000540 ! abnormal protein transport is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0015031 ! protein transport relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0015031 ! protein transport created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000542 name: increased rate of protein transport def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the rate, or speed, of protein transport is increased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased rate of protein transport during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased rate of protein transport during vegetative growth" EXACT [PomBase:mah] synonym: "protein transport: increased rate" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000540 ! abnormal protein transport is_a: PATO:0000912 ! increased rate intersection_of: PATO:0000912 ! increased rate intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0015031 ! protein transport relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0015031 ! protein transport created_by: midori creation_date: 2011-08-15T11:08:30Z [Term] id: FYPO:0000544 name: abolished protein modification during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which protein modification does not occur. All modifications may be affected, or only modifications of a certain type, or on specific proteins, or even specific sites within specific proteins." [PomBase:mah] synonym: "abolished protein modification during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein/peptide modification during vegetative growth" EXACT [PomBase:mah] synonym: "absent protein/peptide modification during vegetative growth" EXACT [PomBase:mah] synonym: "protein modification abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000329 ! abnormal protein modification during vegetative growth is_a: FYPO:0002497 ! abolished protein modification intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0006464 ! cellular protein modification process relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0006464 ! cellular protein modification process created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000545 name: decreased protein modification during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of protein modification is decreased. All modifications may be affected, or only modifications of a certain type, or on specific proteins, or even specific sites within specific proteins." [PomBase:mah] synonym: "decreased protein modification during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein/peptide modification during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein modification during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000329 ! abnormal protein modification during vegetative growth is_a: FYPO:0002498 ! decreased protein modification intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006464 ! cellular protein modification process relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006464 ! cellular protein modification process created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000546 name: delayed protein modification def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which protein modification begins later than normal. All modifications may be affected, or only modifications of a certain type, or on specific proteins, or even specific sites within specific proteins." [PomBase:mah] synonym: "delayed protein modification during mitotic cell cycle" RELATED [PomBase:mah] synonym: "delayed protein modification during vegetative growth" EXACT [PomBase:mah] synonym: "delayed protein/peptide modification" EXACT [PomBase:mah] synonym: "protein/peptide modification: delayed" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000329 ! abnormal protein modification during vegetative growth is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006464 ! cellular protein modification process relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006464 ! cellular protein modification process created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000547 name: increased protein modification during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of protein modification is increased. All modifications may be affected, or only modifications of a certain type, or on specific proteins, or even specific sites within specific proteins." [PomBase:mah] synonym: "increased protein modification during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein/peptide modification during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000329 ! abnormal protein modification during vegetative growth is_a: FYPO:0002499 ! increased protein modification intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006464 ! cellular protein modification process relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006464 ! cellular protein modification process created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000548 name: increased duration of protein modification def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the duration of protein modification processes is increased. All modifications may be affected, or only modifications of a certain type, or on specific proteins, or even specific sites within specific proteins." [PomBase:mah] synonym: "increased duration of protein modification during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased duration of protein modification during vegetative growth" EXACT [PomBase:mah] synonym: "increased duration of protein/peptide modification" EXACT [PomBase:mah] synonym: "prolonged protein modification" EXACT [PomBase:mah] synonym: "protein/peptide modification: increased duration" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000329 ! abnormal protein modification during vegetative growth is_a: PATO:0000498 ! increased duration intersection_of: PATO:0000498 ! increased duration intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006464 ! cellular protein modification process relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006464 ! cellular protein modification process created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000549 name: normal protein modification during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which protein modification is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal protein modification during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein/peptide modification during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000859 ! normal metabolic process during vegetative growth is_a: FYPO:0002495 ! normal protein modification intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006464 ! cellular protein modification process intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006464 ! cellular protein modification process relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000550 name: abnormal pseudohyphal growth alt_id: FYPO:0000435 def: "A cellular process phenotype in which pseudohyphal growth is abnormal." [PomBase:mah] comment: Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "abnormal filamentous growth" BROAD [PomBase:mah] synonym: "filamentous growth: abnormal" BROAD [SGD:phenotype_annotation] synonym: "pseudohyphal growth: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0002862 ! abnormal cell growth intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0007124 ! pseudohyphal growth intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0007124 ! pseudohyphal growth relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000551 name: pseudohyphal growth abolished alt_id: FYPO:0000436 def: "A cellular process phenotype in which pseudohyphal growth does not occur." [PomBase:mah] synonym: "abolished filamentous growth" BROAD [PomBase:mah] synonym: "abolished pseudohyphal growth" EXACT [PomBase:mah] synonym: "absent filamentous growth" BROAD [PomBase:mah] synonym: "absent pseudohyphal growth" EXACT [PomBase:mah] synonym: "filamentous growth abolished" BROAD [PomBase:mah] synonym: "filamentous growth: absent" BROAD [SGD:phenotype_annotation] synonym: "pseudohyphal growth: absent" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000550 ! abnormal pseudohyphal growth is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0007124 ! pseudohyphal growth relationship: towards GO:0007124 ! pseudohyphal growth created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000552 name: decreased pseudohyphal growth alt_id: FYPO:0000437 def: "A cellular process phenotype in which the occurrence of pseudohyphal growth is decreased." [PomBase:mah] synonym: "decreased filamentous growth" BROAD [PomBase:mah] synonym: "filamentous growth: decreased" BROAD [SGD:phenotype_annotation] synonym: "pseudohyphal growth: decreased" EXACT [SGD:phenotype_annotation] synonym: "reduced pseudohyphal growth" EXACT [PomBase:mah] is_a: FYPO:0000550 ! abnormal pseudohyphal growth is_a: FYPO:0004075 ! decreased cell growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0007124 ! pseudohyphal growth relationship: inheres_in GO:0007124 ! pseudohyphal growth created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000553 name: increased pseudohyphal growth during cellular hyperosmotic response alt_id: FYPO:0000438 def: "A cellular process phenotype in which the occurrence of pseudohyphal growth is increased during a cellular hyperosmotic response." [PomBase:mah] synonym: "increased filamentous growth during cellular hyperosmotic response" BROAD [PomBase:mah] is_a: FYPO:0003776 ! increased pseudohyphal growth intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0071474 ! cellular hyperosmotic response intersection_of: inheres_in GO:0007124 ! pseudohyphal growth relationship: happens_during GO:0071474 ! cellular hyperosmotic response relationship: inheres_in GO:0007124 ! pseudohyphal growth created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000554 name: normal pseudohyphal growth alt_id: FYPO:0000439 def: "A cell population phenotype in which pseudohyphal growth is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "filamentous growth: normal" BROAD [SGD:phenotype_annotation] synonym: "normal filamentous growth" BROAD [PomBase:mah] synonym: "pseudohyphal growth: normal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0002062 ! normal cell growth intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0007124 ! pseudohyphal growth intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0007124 ! pseudohyphal growth relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000555 name: abnormal re-entry into mitotic cell cycle after pheromone arrest def: "A cellular process phenotype in which re-entry into the mitotic cell cycle after pheromone arrest is abnormal." [PomBase:mah] synonym: "abnormal recovery from pheromone-induced cell cycle arrest" EXACT [PomBase:mah] synonym: "recovery from pheromone-induced cell cycle arrest: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000145 ! regulation phenotype is_a: FYPO:0000302 ! abnormal response to pheromone is_a: FYPO:0002734 ! abnormal cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0000321 ! re-entry into mitotic cell cycle after pheromone arrest intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0000321 ! re-entry into mitotic cell cycle after pheromone arrest relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000556 name: abolished re-entry into mitotic cell cycle after pheromone arrest def: "A cellular process phenotype in which re-entry into the mitotic cell cycle after pheromone arrest does not occur." [PomBase:mah] synonym: "absent recovery from pheromone-induced cell cycle arrest" EXACT [PomBase:mah] synonym: "re-entry into mitotic cell cycle after pheromone arrest abolished" EXACT [PomBase:mah] synonym: "recovery from pheromone-induced cell cycle arrest abolished" EXACT [PomBase:mah] synonym: "recovery from pheromone-induced cell cycle arrest: absent" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000555 ! abnormal re-entry into mitotic cell cycle after pheromone arrest is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0000321 ! re-entry into mitotic cell cycle after pheromone arrest relationship: towards GO:0000321 ! re-entry into mitotic cell cycle after pheromone arrest created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000557 name: decreased re-entry into mitotic cell cycle after pheromone arrest def: "A cellular process phenotype in which the occurrence of re-entry into the mitotic cell cycle after pheromone arrest is decreased." [PomBase:mah] synonym: "decreased recovery from pheromone-induced cell cycle arrest" EXACT [PomBase:mah] synonym: "recovery from pheromone-induced cell cycle arrest: decreased" EXACT [SGD:phenotype_annotation] synonym: "reduced re-entry into mitotic cell cycle after pheromone arrest" EXACT [PomBase:mah] is_a: FYPO:0000555 ! abnormal re-entry into mitotic cell cycle after pheromone arrest is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0000321 ! re-entry into mitotic cell cycle after pheromone arrest relationship: inheres_in GO:0000321 ! re-entry into mitotic cell cycle after pheromone arrest created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000558 name: increased re-entry into mitotic cell cycle after pheromone arrest def: "A cellular process phenotype in which the occurrence of re-entry into the mitotic cell cycle after pheromone arrest is increased." [PomBase:mah] synonym: "increased recovery from pheromone-induced cell cycle arrest" EXACT [PomBase:mah] synonym: "recovery from pheromone-induced cell cycle arrest: increased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000555 ! abnormal re-entry into mitotic cell cycle after pheromone arrest is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0000321 ! re-entry into mitotic cell cycle after pheromone arrest relationship: inheres_in GO:0000321 ! re-entry into mitotic cell cycle after pheromone arrest created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000559 name: increased rate of re-entry into mitotic cell cycle after pheromone arrest def: "A cellular process phenotype in which the rate, or speed, of re-entry into the mitotic cell cycle after pheromone arrest is increased." [PomBase:mah] synonym: "increased rate of recovery from pheromone-induced cell cycle arrest" EXACT [PomBase:mah] synonym: "recovery from pheromone-induced cell cycle arrest: increased rate" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000555 ! abnormal re-entry into mitotic cell cycle after pheromone arrest is_a: PATO:0000912 ! increased rate intersection_of: PATO:0000912 ! increased rate intersection_of: inheres_in GO:0000321 ! re-entry into mitotic cell cycle after pheromone arrest relationship: inheres_in GO:0000321 ! re-entry into mitotic cell cycle after pheromone arrest created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000560 name: normal re-entry into mitotic cell cycle after pheromone arrest def: "A cellular process phenotype in which re-entry into the mitotic cell cycle after pheromone arrest is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal recovery from pheromone-induced cell cycle arrest" EXACT [PomBase:mah] synonym: "recovery from pheromone-induced cell cycle arrest: normal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000627 ! normal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0000321 ! re-entry into mitotic cell cycle after pheromone arrest intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0000321 ! re-entry into mitotic cell cycle after pheromone arrest relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000561 name: normal mitotic G1 phase progression def: "A cellular process phenotype in which progression through the G1 phase of the mitotic cell cycle is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "mitotic cell cycle progression in G1 phase: normal" EXACT [SGD:phenotype_annotation] synonym: "normal mitotic cell cycle progression in G1" EXACT [PomBase:mah] synonym: "normal mitotic G1 phase progression during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002740 ! normal mitotic cell cycle phase intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000080 ! mitotic G1 phase intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000080 ! mitotic G1 phase relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-08-16T10:03:01Z [Term] id: FYPO:0000562 name: abolished cellular respiration def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which cellular respiration does not occur." [PomBase:mah] synonym: "abolished cellular respiration during mitotic cell cycle" RELATED [PomBase:mah] synonym: "absent respiratory metabolism" EXACT [PomBase:mah] synonym: "cellular respiration abolished" EXACT [PomBase:mah] synonym: "cellular respiration abolished during vegetative growth" EXACT [PomBase:mah] synonym: "respiration abolished" BROAD [PomBase:mah] synonym: "respiratory metabolism abolished" EXACT [PomBase:mah] synonym: "respiratory metabolism: absent" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000078 ! abnormal cellular respiration is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0045333 ! cellular respiration relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0045333 ! cellular respiration created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000563 name: abnormal mitotic G2 phase progression def: "A cellular process phenotype in which progression through the G2 phase of the mitotic cell cycle is abnormal." [PomBase:mah] synonym: "abnormal mitotic cell cycle progression in G2" EXACT [PomBase:mah] synonym: "abnormal mitotic G2 phase progression during vegetative growth" EXACT [PomBase:mah] synonym: "mitotic cell cycle progression in G2 phase: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0002736 ! abnormal mitotic cell cycle phase intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000085 ! mitotic G2 phase intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000085 ! mitotic G2 phase relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-16T10:03:01Z [Term] id: FYPO:0000564 name: decreased rate of cellular respiration def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the rate, or speed, of cellular respiration is decreased." [PomBase:mah] synonym: "decreased rate of cellular respiration during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased rate of cellular respiration during vegetative growth" EXACT [PomBase:mah] synonym: "decreased rate of respiration" BROAD [PomBase:mah] synonym: "decreased rate of respiratory metabolism" EXACT [PomBase:mah] synonym: "reduced rate of cellular respiration" EXACT [PomBase:mah] synonym: "respiratory metabolism: decreased rate" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000078 ! abnormal cellular respiration is_a: PATO:0000911 ! decreased rate intersection_of: PATO:0000911 ! decreased rate intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0045333 ! cellular respiration relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0045333 ! cellular respiration created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000565 name: increased cellular respiration def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of cellular respiration is increased." [PomBase:mah] synonym: "increased cellular respiration during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular respiration during vegetative growth" EXACT [PomBase:mah] synonym: "increased respiration" BROAD [PomBase:mah] synonym: "increased respiratory metabolism" EXACT [PomBase:mah] synonym: "respiratory metabolism: increased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000078 ! abnormal cellular respiration is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0045333 ! cellular respiration relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0045333 ! cellular respiration created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000566 name: normal cellular respiration def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which cellular respiration is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular respiration during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular respiration during vegetative growth" EXACT [PomBase:mah] synonym: "normal respiration" BROAD [PomBase:mah] synonym: "normal respiratory metabolism" EXACT [PomBase:mah] synonym: "respiratory metabolism: normal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000859 ! normal metabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0045333 ! cellular respiration intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0045333 ! cellular respiration relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000567 name: decreased duration of septation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the duration of septation is decreased." [PomBase:mah] synonym: "decreased barrier septum formation involved in mitotic cytokinesis" RELATED [PomBase:mah] synonym: "decreased duration of barrier septum formation involved in mitotic cytokinesis" EXACT [PomBase:mah] synonym: "decreased duration of mitotic barrier septum assembly" EXACT [GO:0000917, PomBase:mah] synonym: "decreased duration of septation during vegetative growth" EXACT [PomBase:mah] synonym: "decreased septation" RELATED [PomBase:mah] synonym: "decreased septum formation" RELATED [PomBase:mah] synonym: "reduced duration of septation" EXACT [PomBase:mah] synonym: "septum formation: decreased" BROAD [SGD:phenotype_annotation] is_a: FYPO:0000117 ! abnormal septation is_a: PATO:0000499 ! decreased duration intersection_of: PATO:0000499 ! decreased duration intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000917 ! barrier septum assembly relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000917 ! barrier septum assembly created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000568 name: abnormal shmoo formation def: "A cellular process phenotype in which mating projection assembly is abnormal." [PomBase:mah] synonym: "abnormal conjugation tube formation" EXACT [PomBase:mah] synonym: "abnormal mating projection assembly" EXACT [PomBase:mah] synonym: "abnormal mating projection formation" EXACT [PomBase:mah] synonym: "abnormal shmoo assembly" EXACT [PomBase:mah] synonym: "shmoo formation: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000336 ! abnormal cellular component assembly is_a: FYPO:0000679 ! developmental process phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0031382 ! mating projection assembly intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0031382 ! mating projection assembly relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000569 name: abolished shmoo formation def: "A cellular process phenotype in which mating projection assembly does not occur." [PomBase:mah] synonym: "abolished conjugation tube formation" EXACT [PomBase:mah] synonym: "absent shmoo formation" EXACT [PomBase:mah] synonym: "mating projection assembly abolished" EXACT [PomBase:mah] synonym: "mating projection formation abolished" EXACT [PomBase:mah] synonym: "shmoo assembly abolished" EXACT [PomBase:mah] synonym: "shmoo formation abolished" EXACT [PomBase:mah] synonym: "shmoo formation: absent" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000568 ! abnormal shmoo formation is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0031382 ! mating projection assembly relationship: towards GO:0031382 ! mating projection assembly created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000570 name: decreased shmoo formation def: "A cellular process phenotype in which the occurrence of mating projection assembly is decreased." [PomBase:mah] synonym: "decreased conjugation tube formation" EXACT [PomBase:mah] synonym: "decreased mating projection assembly" EXACT [PomBase:mah] synonym: "decreased mating projection formation" EXACT [PomBase:mah] synonym: "decreased shmoo assembly" EXACT [PomBase:mah] synonym: "reduced shmoo formation" EXACT [PomBase:mah] synonym: "shmoo formation: decreased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000568 ! abnormal shmoo formation is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0031382 ! mating projection assembly relationship: inheres_in GO:0031382 ! mating projection assembly created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000571 name: decreased rate of shmoo formation def: "A cellular process phenotype in which the rate, or speed, of mating projection assembly is decreased." [PomBase:mah] synonym: "decreased rate of conjugation tube formation" EXACT [PomBase:mah] synonym: "decreased rate of mating projection assembly" EXACT [PomBase:mah] synonym: "decreased rate of mating projection formation" EXACT [PomBase:mah] synonym: "decreased rate of shmoo assembly" EXACT [PomBase:mah] synonym: "reduced rate of shmoo formation" EXACT [PomBase:mah] synonym: "shmoo formation: decreased rate" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000568 ! abnormal shmoo formation is_a: PATO:0000911 ! decreased rate intersection_of: PATO:0000911 ! decreased rate intersection_of: inheres_in GO:0031382 ! mating projection assembly relationship: inheres_in GO:0031382 ! mating projection assembly created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000572 name: increased rate of shmoo formation def: "A cellular process phenotype in which the rate, or speed, of mating projection assembly is increased." [PomBase:mah] synonym: "increased rate of conjugation tube formation" EXACT [PomBase:mah] synonym: "increased rate of mating projection assembly" EXACT [PomBase:mah] synonym: "increased rate of mating projection formation" EXACT [PomBase:mah] synonym: "increased rate of shmoo assembly" EXACT [PomBase:mah] synonym: "shmoo formation: increased rate" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000568 ! abnormal shmoo formation is_a: PATO:0000912 ! increased rate intersection_of: PATO:0000912 ! increased rate intersection_of: inheres_in GO:0031382 ! mating projection assembly relationship: inheres_in GO:0031382 ! mating projection assembly created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000573 name: normal shmoo formation def: "A cellular process phenotype in which mating projection assembly is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal conjugation tube formation" EXACT [PomBase:mah] synonym: "normal mating projection assembly" EXACT [PomBase:mah] synonym: "normal mating projection formation" EXACT [PomBase:mah] synonym: "normal shmoo assembly" EXACT [PomBase:mah] synonym: "shmoo formation: normal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000627 ! normal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0031382 ! mating projection assembly intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0031382 ! mating projection assembly relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000574 name: abnormal gene silencing def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which gene silencing is abnormal." [PomBase:mah] synonym: "abnormal gene silencing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal gene silencing during vegetative growth" EXACT [PomBase:mah] synonym: "silencing: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001333 ! gene expression regulation phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0016458 ! gene silencing intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0016458 ! gene silencing relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000575 name: abolished gene silencing def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which gene silencing does not occur." [PomBase:mah] synonym: "abolished gene silencing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "absent silencing" EXACT [PomBase:mah] synonym: "gene silencing abolished" EXACT [PomBase:mah] synonym: "gene silencing abolished during vegetative growth" EXACT [PomBase:mah] synonym: "silencing: absent" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000574 ! abnormal gene silencing is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0016458 ! gene silencing relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0016458 ! gene silencing created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000576 name: decreased gene silencing def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of gene silencing is decreased." [PomBase:mah] synonym: "decreased gene silencing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased gene silencing during vegetative growth" EXACT [PomBase:mah] synonym: "reduced gene silencing" EXACT [PomBase:mah] synonym: "silencing: decreased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000574 ! abnormal gene silencing is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0016458 ! gene silencing relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0016458 ! gene silencing created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000577 name: increased gene silencing def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of gene silencing is increased." [PomBase:mah] synonym: "increased gene silencing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased gene silencing during vegetative growth" EXACT [PomBase:mah] synonym: "silencing: increased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000574 ! abnormal gene silencing is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0016458 ! gene silencing relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_output FYPO:0001117 ! decreased RNA level during vegetative growth relationship: inheres_in GO:0016458 ! gene silencing created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000578 name: normal gene silencing def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which gene silencing is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal gene silencing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal gene silencing during vegetative growth" EXACT [PomBase:mah] synonym: "silencing: normal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001319 ! normal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0016458 ! gene silencing intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0016458 ! gene silencing relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000579 name: normal spore germination def: "A cellular process phenotype in which spore germination is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "spore germination: normal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000627 ! normal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0009847 ! spore germination intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0009847 ! spore germination relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000580 name: abnormal ascospore wall biogenesis def: "A cellular process phenotype in which ascospore wall biogenesis is abnormal." [PomBase:mah] synonym: "abnormal ascospore wall organization" RELATED [PomBase:mah] synonym: "abnormal spore wall formation" RELATED [PomBase:mah] synonym: "abnormal spore wall organization" RELATED [PomBase:vw] synonym: "spore wall formation: abnormal" RELATED [SGD:phenotype_annotation] is_a: FYPO:0000174 ! abnormal cell wall biogenesis is_a: FYPO:0002739 ! abnormal meiotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0070591 ! ascospore wall biogenesis intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0070591 ! ascospore wall biogenesis relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000581 name: decreased spore germination def: "A cellular process phenotype in which the occurrence of spore germination is decreased. At the cellular level, an individual spore is less likely to germinate than normal." [PomBase:mah] comment: Note that this phenotype is usually assayed by observing a population of spores and measuring how many germinate. This term may be replaced by a cell population term in the future. synonym: "decreased spore viability" RELATED [PomBase:mah] synonym: "reduced spore germination" EXACT [PomBase:mah] synonym: "reduced spore viability" RELATED [PomBase:mah] synonym: "spore germination: decreased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000305 ! abnormal spore germination is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0009847 ! spore germination relationship: inheres_in GO:0009847 ! spore germination created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000582 name: decreased rate of spore germination def: "A cellular process phenotype in which the rate, or speed, of spore germination is decreased." [PomBase:mah] synonym: "reduced rate of spore germination" EXACT [PomBase:mah] synonym: "spore germination: decreased rate" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000305 ! abnormal spore germination is_a: PATO:0000911 ! decreased rate intersection_of: PATO:0000911 ! decreased rate intersection_of: inheres_in GO:0009847 ! spore germination relationship: inheres_in GO:0009847 ! spore germination created_by: midori creation_date: 2011-08-15T11:41:34Z [Term] id: FYPO:0000583 name: abolished sporulation def: "A cellular process phenotype in which ascospore formation does not occur." [PomBase:mah] synonym: "absent sporulation" EXACT [PomBase:mah] synonym: "ascospore formation abolished" EXACT [PomBase:mah] synonym: "sporulation abolished" EXACT [PomBase:mah] synonym: "sporulation: absent" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000121 ! abnormal sporulation is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0030437 ! ascospore formation relationship: towards GO:0030437 ! ascospore formation created_by: midori creation_date: 2011-08-15T12:00:20Z [Term] id: FYPO:0000584 name: decreased sporulation def: "A cellular process phenotype in which the occurrence of ascospore formation is decreased." [PomBase:mah] synonym: "decreased ascospore formation" EXACT [PomBase:mah] synonym: "decreased spore viability" RELATED [PomBase:vw] synonym: "decreased sporulation frequency" EXACT [PomBase:mah] synonym: "reduced spore viability" RELATED [PomBase:vw] synonym: "reduced sporulation" EXACT [PomBase:mah] synonym: "sporulation: decreased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000121 ! abnormal sporulation is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0030437 ! ascospore formation relationship: inheres_in GO:0030437 ! ascospore formation created_by: midori creation_date: 2011-08-15T12:00:20Z [Term] id: FYPO:0000585 name: abolished ascospore wall biogenesis def: "A cellular process phenotype in which ascospore wall biogenesis does not occur." [PomBase:mah] synonym: "absent spore wall formation" RELATED [PomBase:mah] synonym: "ascospore wall biogenesis abolished" EXACT [PomBase:mah] synonym: "spore wall formation abolished" RELATED [PomBase:mah] synonym: "spore wall formation: absent" RELATED [SGD:phenotype_annotation] is_a: FYPO:0000580 ! abnormal ascospore wall biogenesis is_a: FYPO:0003639 ! abolished cell wall biogenesis intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0070591 ! ascospore wall biogenesis relationship: towards GO:0070591 ! ascospore wall biogenesis created_by: midori creation_date: 2011-08-15T12:00:20Z [Term] id: FYPO:0000586 name: abolished ascospore wall assembly def: "A cellular process phenotype in which ascospore wall assembly does not occur." [PomBase:mah] synonym: "absent spore wall formation" RELATED [PomBase:mah] synonym: "ascospore wall assembly abolished" EXACT [PomBase:mah] synonym: "spore wall formation abolished" RELATED [PomBase:mah] synonym: "spore wall formation: absent" RELATED [SGD:phenotype_annotation] is_a: FYPO:0000175 ! abnormal ascospore wall assembly is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0030476 ! ascospore wall assembly relationship: towards GO:0030476 ! ascospore wall assembly created_by: midori creation_date: 2011-08-15T12:00:20Z [Term] id: FYPO:0000587 name: delayed sporulation def: "A cellular process phenotype in which ascospore formation begins later than normal." [PomBase:mah] synonym: "delayed ascospore formation" EXACT [PomBase:mah] synonym: "sporulation: delayed" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000121 ! abnormal sporulation is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: inheres_in GO:0030437 ! ascospore formation relationship: inheres_in GO:0030437 ! ascospore formation created_by: midori creation_date: 2011-08-15T12:00:20Z [Term] id: FYPO:0000588 name: increased sporulation def: "A cellular process phenotype in which the occurrence of ascospore formation is increased." [PomBase:mah] synonym: "increased ascospore formation" EXACT [PomBase:mah] synonym: "sporulation: increased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000121 ! abnormal sporulation is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0030437 ! ascospore formation relationship: inheres_in GO:0030437 ! ascospore formation created_by: midori creation_date: 2011-08-15T12:00:20Z [Term] id: FYPO:0000589 name: increased rate of sporulation def: "A cellular process phenotype in which the rate, or speed, of ascospore formation is increased, i.e. sporulation takes place more rapidly than in wild type." [PomBase:mah] synonym: "increased rate of ascospore formation" EXACT [PomBase:mah] synonym: "sporulation: increased rate" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000121 ! abnormal sporulation is_a: PATO:0000912 ! increased rate intersection_of: PATO:0000912 ! increased rate intersection_of: inheres_in GO:0030437 ! ascospore formation relationship: inheres_in GO:0030437 ! ascospore formation created_by: midori creation_date: 2011-08-15T12:00:20Z [Term] id: FYPO:0000590 name: normal sporulation def: "A cellular process phenotype in which ascospore formation is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal ascospore formation" EXACT [PomBase:mah] synonym: "sporulation: normal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000627 ! normal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0030437 ! ascospore formation intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0030437 ! ascospore formation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-08-15T12:00:20Z [Term] id: FYPO:0000591 name: abnormal transposition def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transposition is abnormal." [PomBase:mah] synonym: "abnormal transposable element transposition" EXACT [PomBase:mah] synonym: "abnormal transposition during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal transposition during vegetative growth" EXACT [PomBase:mah] synonym: "transposable element transposition: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0032196 ! transposition intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0032196 ! transposition relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-15T12:00:20Z [Term] id: FYPO:0000592 name: abolished transposition def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transposition does not occur." [PomBase:mah] synonym: "abolished transposition during mitotic cell cycle" RELATED [PomBase:mah] synonym: "absent transposable element transposition" EXACT [PomBase:mah] synonym: "transposable element transposition abolished" EXACT [PomBase:mah] synonym: "transposable element transposition: absent" EXACT [SGD:phenotype_annotation] synonym: "transposition abolished" EXACT [PomBase:mah] synonym: "transposition abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000591 ! abnormal transposition is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0032196 ! transposition relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0032196 ! transposition created_by: midori creation_date: 2011-08-15T12:00:20Z [Term] id: FYPO:0000593 name: decreased transposition def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of transposition is decreased." [PomBase:mah] synonym: "decreased transposable element transposition" EXACT [PomBase:mah] synonym: "decreased transposition during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased transposition during vegetative growth" EXACT [PomBase:mah] synonym: "reduced transposition" EXACT [PomBase:mah] synonym: "transposable element transposition: decreased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000591 ! abnormal transposition is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0032196 ! transposition relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0032196 ! transposition created_by: midori creation_date: 2011-08-15T12:00:20Z [Term] id: FYPO:0000594 name: increased transposition def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of transposition is increased." [PomBase:mah] synonym: "increased transposable element transposition" EXACT [PomBase:mah] synonym: "increased transposition during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased transposition during vegetative growth" EXACT [PomBase:mah] synonym: "transposable element transposition: increased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000591 ! abnormal transposition is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0032196 ! transposition relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0032196 ! transposition created_by: midori creation_date: 2011-08-15T12:00:20Z [Term] id: FYPO:0000595 name: increased rate of transposition def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the rate, or speed, of transposition is increased." [PomBase:mah] synonym: "increased rate of transposable element transposition" EXACT [PomBase:mah] synonym: "increased rate of transposition during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased rate of transposition during vegetative growth" EXACT [PomBase:mah] synonym: "transposable element transposition: increased rate" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000591 ! abnormal transposition is_a: PATO:0000912 ! increased rate intersection_of: PATO:0000912 ! increased rate intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0032196 ! transposition relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0032196 ! transposition created_by: midori creation_date: 2011-08-15T12:00:20Z [Term] id: FYPO:0000596 name: normal transposition def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transposition is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal transposable element transposition" EXACT [PomBase:mah] synonym: "normal transposition during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal transposition during vegetative growth" EXACT [PomBase:mah] synonym: "transposable element transposition: normal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001319 ! normal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0032196 ! transposition intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0032196 ! transposition relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-08-15T12:00:20Z [Term] id: FYPO:0000597 name: abnormal vacuolar transport during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which vacuolar transport is abnormal." [PomBase:mah] synonym: "abnormal vacuolar transport during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001336 ! transport phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0003578 ! abnormal vacuolar transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0007034 ! vacuolar transport intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0007034 ! vacuolar transport relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-15T12:00:20Z [Term] id: FYPO:0000598 name: decreased vacuolar transport def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of vacuolar transport is decreased." [PomBase:mah] synonym: "decreased vacuolar transport during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased vacuolar transport during vegetative growth" EXACT [PomBase:mah] synonym: "reduced vacuolar transport" EXACT [PomBase:mah] synonym: "vacuolar transport: decreased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000464 ! decreased intracellular transport is_a: FYPO:0000597 ! abnormal vacuolar transport during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0007034 ! vacuolar transport relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0007034 ! vacuolar transport created_by: midori creation_date: 2011-08-15T12:00:20Z [Term] id: FYPO:0000599 name: decreased rate of vacuolar transport def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the rate, or speed, of vacuolar transport is decreased." [PomBase:mah] synonym: "decreased rate of vacuolar transport during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased rate of vacuolar transport during vegetative growth" EXACT [PomBase:mah] synonym: "reduced rate of vacuolar transport" EXACT [PomBase:mah] synonym: "vacuolar transport: decreased rate" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000597 ! abnormal vacuolar transport during vegetative growth is_a: PATO:0000911 ! decreased rate intersection_of: PATO:0000911 ! decreased rate intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0007034 ! vacuolar transport relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0007034 ! vacuolar transport created_by: midori creation_date: 2011-08-15T12:00:20Z [Term] id: FYPO:0000600 name: delayed vacuolar transport def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which vacuolar transport begins later than normal." [PomBase:mah] synonym: "delayed vacuolar transport during mitotic cell cycle" RELATED [PomBase:mah] synonym: "delayed vacuolar transport during vegetative growth" EXACT [PomBase:mah] synonym: "vacuolar transport: delayed" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000597 ! abnormal vacuolar transport during vegetative growth is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0007034 ! vacuolar transport relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0007034 ! vacuolar transport created_by: midori creation_date: 2011-08-15T12:00:20Z [Term] id: FYPO:0000601 name: normal vacuolar transport def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which vacuolar transport is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal vacuolar transport during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal vacuolar transport during vegetative growth" EXACT [PomBase:mah] synonym: "vacuolar transport: normal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001071 ! normal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0007034 ! vacuolar transport intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0007034 ! vacuolar transport relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-08-15T12:00:20Z [Term] id: FYPO:0000602 name: abnormal mitotic G1 phase progression def: "A cellular process phenotype in which progression through the G1 phase of the mitotic cell cycle is abnormal." [PomBase:mah] synonym: "abnormal mitotic cell cycle progression in G1" EXACT [PomBase:mah] synonym: "abnormal mitotic G1 phase progression during vegetative growth" EXACT [PomBase:mah] synonym: "mitotic cell cycle progression in G1 phase: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0002736 ! abnormal mitotic cell cycle phase intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000080 ! mitotic G1 phase intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000080 ! mitotic G1 phase relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-15T12:00:20Z [Term] id: FYPO:0000603 name: decreased duration of mitotic G1 phase def: "A cellular process phenotype in which the duration of G1 phase of a mitotic cell cycle is shorter than normal." [PomBase:mah] synonym: "decreased duration of mitotic G1 phase during vegetative growth" EXACT [PomBase:mah] synonym: "mitotic cell cycle progression in G1 phase: decreased duration" EXACT [SGD:phenotype_annotation] synonym: "reduced duration of mitotic G1 phase" EXACT [PomBase:mah] is_a: FYPO:0000602 ! abnormal mitotic G1 phase progression is_a: FYPO:0001070 ! decreased duration of mitotic cell cycle phase intersection_of: PATO:0000499 ! decreased duration intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000080 ! mitotic G1 phase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000080 ! mitotic G1 phase created_by: midori creation_date: 2011-08-15T12:00:20Z [Term] id: FYPO:0000607 name: abnormal mitotic M phase progression def: "A cellular process phenotype in which progression through M phase of the mitotic cell cycle is abnormal." [PomBase:mah] synonym: "abnormal mitotic cell cycle progression in M" EXACT [PomBase:mah] synonym: "abnormal mitotic M phase progression during vegetative growth" EXACT [PomBase:mah] synonym: "mitotic cell cycle progression in M phase: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0002736 ! abnormal mitotic cell cycle phase intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000087 ! mitotic M phase intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000087 ! mitotic M phase relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-16T10:03:01Z [Term] id: FYPO:0000608 name: abnormal cell cycle arrest in mitotic M phase def: "A cellular process phenotype in which progression through the mitotic cell cycle is arrested in M phase under conditions where arrest does not normally occur." [PomBase:mah] comment: M phase is often identified by the degree of chromosome condensation. synonym: "abnormal cell cycle arrest in mitotic M phase during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal mitotic cell cycle arrest in M phase" EXACT [PomBase:mah] synonym: "abnormal mitotic cell cycle arrest with condensed chromosomes" RELATED [PomBase:vw] synonym: "abnormal mitotic nuclear division arrest" EXACT [PomBase:vw] synonym: "mitotic cell cycle progression in M phase: arrested" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000502 ! abnormally arrested mitotic cell cycle progression is_a: FYPO:0000607 ! abnormal mitotic M phase progression intersection_of: during GO:0000087 ! mitotic M phase intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0071850 ! mitotic cell cycle arrest intersection_of: qualifier PATO:0000467 ! present relationship: during GO:0000087 ! mitotic M phase relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_output FYPO:0000337 ! abnormal mitosis relationship: inheres_in_part_of GO:0071850 ! mitotic cell cycle arrest relationship: qualifier PATO:0000467 ! present created_by: midori creation_date: 2011-08-16T10:03:01Z [Term] id: FYPO:0000610 name: abnormal mitotic S phase progression def: "A cellular process phenotype in which progression through S phase of the mitotic cell cycle is abnormal." [PomBase:mah] synonym: "abnormal mitotic cell cycle progression in S" EXACT [PomBase:mah] synonym: "abnormal mitotic S phase progression during vegetative growth" EXACT [PomBase:mah] synonym: "mitotic cell cycle progression in S phase: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0002736 ! abnormal mitotic cell cycle phase intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000084 ! mitotic S phase intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000084 ! mitotic S phase relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-16T10:03:01Z [Term] id: FYPO:0000611 name: cell cycle arrest in mitotic S phase def: "A cellular process phenotype in which progression through the mitotic cell cycle is arrested in S phase." [PomBase:mah] comment: Cells arrested in S phase typically have more than 1C, but less than 2C, DNA content. synonym: "cell cycle arrest in mitotic S phase during vegetative growth" EXACT [PomBase:mah] synonym: "mitotic cell cycle arrest in S phase" EXACT [PomBase:mah] synonym: "mitotic cell cycle progression in S phase: arrested" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000837 ! cell cycle arrest in mitotic interphase intersection_of: during GO:0000084 ! mitotic S phase intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071850 ! mitotic cell cycle arrest intersection_of: qualifier PATO:0000467 ! present relationship: during GO:0000084 ! mitotic S phase relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071850 ! mitotic cell cycle arrest relationship: qualifier PATO:0000467 ! present created_by: midori creation_date: 2011-08-16T10:03:01Z [Term] id: FYPO:0000614 name: increased duration of mitotic S phase alt_id: FYPO:0000612 alt_id: FYPO:0000613 def: "A cellular process phenotype in which the duration of progression through S phase of the mitotic cell cycle is longer than normal." [PomBase:mah] synonym: "decreased rate of mitotic S phase progression" RELATED [PomBase:mah] synonym: "delayed mitotic S phase progression" RELATED [PomBase:mah] synonym: "delayed mitotic S phase progression during vegetative growth" RELATED [PomBase:mah] synonym: "increased duration of mitotic S phase during vegetative growth" EXACT [PomBase:mah] synonym: "mitotic cell cycle progression in S phase: decreased rate" RELATED [SGD:phenotype_annotation] synonym: "mitotic cell cycle progression in S phase: delayed" EXACT [SGD:phenotype_annotation] synonym: "mitotic cell cycle progression in S phase: increased duration" EXACT [SGD:phenotype_annotation] synonym: "prolonged mitotic S phase" EXACT [PomBase:mah] synonym: "reduced rate of mitotic S phase progression" RELATED [PomBase:mah] is_a: FYPO:0000610 ! abnormal mitotic S phase progression is_a: FYPO:0001069 ! increased duration of mitotic cell cycle phase intersection_of: PATO:0000498 ! increased duration intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000084 ! mitotic S phase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000084 ! mitotic S phase created_by: midori creation_date: 2011-08-16T10:03:01Z [Term] id: FYPO:0000615 name: decreased duration of mitotic S phase def: "A cellular process phenotype in which the duration of progression through S phase of the mitotic cell cycle is shorter than normal." [PomBase:mah] synonym: "decreased duration of mitotic S phase during vegetative growth" EXACT [PomBase:mah] synonym: "mitotic cell cycle progression in S phase: increased rate" RELATED [SGD:phenotype_annotation] synonym: "reduced duration of mitotic S phase" EXACT [PomBase:mah] is_a: FYPO:0000610 ! abnormal mitotic S phase progression is_a: FYPO:0001070 ! decreased duration of mitotic cell cycle phase intersection_of: PATO:0000499 ! decreased duration intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000084 ! mitotic S phase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000084 ! mitotic S phase created_by: midori creation_date: 2011-08-16T10:03:01Z [Term] id: FYPO:0000616 name: abnormal mitotic anaphase progression def: "A cellular process phenotype in which progression through mitotic anaphase is abnormal." [PomBase:mah] synonym: "abnormal mitotic anaphase progression during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal mitotic cell cycle progression in anaphase" EXACT [PomBase:mah] synonym: "mitotic cell cycle progression in anaphase: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000607 ! abnormal mitotic M phase progression intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000090 ! mitotic anaphase intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000090 ! mitotic anaphase relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-16T10:03:01Z [Term] id: FYPO:0000618 name: increased duration of mitotic anaphase alt_id: FYPO:0000617 def: "A cellular process phenotype in which the duration of progression through the anaphase of mitosis is longer than normal." [PomBase:mah] synonym: "delayed mitotic anaphase progression" RELATED [PomBase:mah] synonym: "increased duration of mitotic anaphase during vegetative growth" EXACT [PomBase:mah] synonym: "increased duration of mitotic anaphase progression" EXACT [PomBase:mah] synonym: "mitotic cell cycle progression in anaphase: delayed" RELATED [SGD:phenotype_annotation] synonym: "mitotic cell cycle progression in anaphase: increased duration" EXACT [SGD:phenotype_annotation] synonym: "prolonged mitotic anaphase" EXACT [PomBase:mah] is_a: FYPO:0000616 ! abnormal mitotic anaphase progression is_a: FYPO:0001069 ! increased duration of mitotic cell cycle phase intersection_of: PATO:0000498 ! increased duration intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000090 ! mitotic anaphase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000090 ! mitotic anaphase created_by: midori creation_date: 2011-08-16T10:03:01Z [Term] id: FYPO:0000619 name: abnormal cell cycle arrest in mitotic anaphase def: "A cellular process phenotype in which progression through the mitotic cell cycle is arrested in anaphase under conditions where arrest does not normally occur." [PomBase:mah] synonym: "abnormal cell cycle arrest in mitotic anaphase during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal mitotic cell cycle arrest in anaphase" EXACT [GO:0000090] synonym: "mitotic cell cycle progression in late anaphase: arrested" NARROW [SGD:phenotype_annotation] is_a: FYPO:0000608 ! abnormal cell cycle arrest in mitotic M phase intersection_of: during GO:0000090 ! mitotic anaphase intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0071850 ! mitotic cell cycle arrest intersection_of: qualifier PATO:0000467 ! present relationship: during GO:0000090 ! mitotic anaphase relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0071850 ! mitotic cell cycle arrest relationship: qualifier PATO:0000467 ! present created_by: midori creation_date: 2011-08-16T10:03:01Z [Term] id: FYPO:0000620 name: abnormal cell cycle arrest in mitotic metaphase def: "A cellular process phenotype in which progression through the mitotic cell cycle is arrested in metaphase under conditions where arrest does not normally occur." [PomBase:mah] comment: Metaphase is defined as the part of mitosis when chromosomes are aligned in the middle of the spindle. If no spindle is present, do not use this term, but consider 'abnormal cell cycle arrest in mitotic prophase' (FYPO:0003145). If you cannot tell whether a spindle is present, or if metaphase cannot be clearly detected, annotate to the more general term 'abnormal cell cycle arrest in mitotic M phase' (FYPO:0000608). synonym: "abnormal cell cycle arrest in mitotic metaphase during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal cell cycle arrest in mitotic metaphase with condensed chromosomes" EXACT [Pombase:vw] synonym: "abnormal mitotic cell cycle arrest in metaphase" EXACT [GO:0000089] synonym: "mitotic cell cycle progression in metaphase: arrested" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000608 ! abnormal cell cycle arrest in mitotic M phase intersection_of: during GO:0000089 ! mitotic metaphase intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0071850 ! mitotic cell cycle arrest intersection_of: qualifier PATO:0000467 ! present relationship: during GO:0000089 ! mitotic metaphase relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0071850 ! mitotic cell cycle arrest relationship: qualifier PATO:0000467 ! present created_by: midori creation_date: 2011-08-16T10:03:01Z [Term] id: FYPO:0000621 name: delayed onset of mitotic metaphase def: "A cellular process phenotype in which the onset of metaphase of mitosis begins later than normal." [PomBase:mah] synonym: "delayed mitotic metaphase" EXACT [PomBase:mah] synonym: "delayed onset of mitotic metaphase during vegetative growth" EXACT [PomBase:mah] synonym: "mitotic cell cycle progression in metaphase: delayed" EXACT [SGD:phenotype_annotation] synonym: "mitotic metaphase delay" EXACT [PomBase:mah] is_a: FYPO:0000607 ! abnormal mitotic M phase progression is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000089 ! mitotic metaphase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000089 ! mitotic metaphase created_by: midori creation_date: 2011-08-16T10:03:01Z [Term] id: FYPO:0000622 name: abnormal cell cycle arrest in mitotic telophase def: "A cellular process phenotype in which progression through the mitotic cell cycle is arrested in telophase under conditions where arrest does not normally occur." [PomBase:mah] synonym: "abnormal cell cycle arrest in mitotic telophase during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal mitotic cell cycle arrest in telophase" EXACT [GO:0000093] synonym: "mitotic cell cycle progression in telophase: arrested" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000608 ! abnormal cell cycle arrest in mitotic M phase intersection_of: during GO:0000093 ! mitotic telophase intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0071850 ! mitotic cell cycle arrest intersection_of: qualifier PATO:0000467 ! present relationship: during GO:0000093 ! mitotic telophase relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0071850 ! mitotic cell cycle arrest relationship: qualifier PATO:0000467 ! present created_by: midori creation_date: 2011-08-16T10:03:01Z [Term] id: FYPO:0000623 name: abnormal positive regulation of transcription def: "A transcription regulation phenotype in which any process of positive regulation of transcription is abnormal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. There may be enough evidence to support annotation to a more specific term such as 'abnormal transcriptional response to pheromone' (FYPO:0000984); if not, it is safer to annotate to 'increased transcription during vegetative growth' (FYPO:0000780) or 'decreased transcription during vegetative growth' (FYPO:0000781) rather than explicitly claiming that an effect on regulation was observed. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "abnormal activation of gene-specific transcription" RELATED [GO:0045893, PomBase:mah] synonym: "abnormal activation of transcription, DNA-dependent" NARROW [GO:0045893, PomBase:mah] synonym: "abnormal positive regulation of cellular transcription, DNA-dependent" EXACT [GO:0045893, PomBase:mah] synonym: "abnormal positive regulation of gene-specific transcription" RELATED [GO:0045893, PomBase:mah] synonym: "abnormal positive regulation of transcription, DNA-dependent" EXACT [GO:0045893, PomBase:mah] synonym: "abnormal stimulation of gene-specific transcription" NARROW [GO:0045893, PomBase:mah] synonym: "abnormal stimulation of transcription, DNA-dependent" NARROW [GO:0045893, PomBase:mah] synonym: "abnormal up regulation of gene-specific transcription" RELATED [GO:0045893, PomBase:mah] synonym: "abnormal up regulation of transcription, DNA-dependent" EXACT [GO:0045893, PomBase:mah] synonym: "abnormal up-regulation of gene-specific transcription" RELATED [GO:0045893, PomBase:mah] synonym: "abnormal up-regulation of transcription, DNA-dependent" EXACT [GO:0045893, PomBase:mah] synonym: "abnormal upregulation of gene-specific transcription" RELATED [GO:0045893, PomBase:mah] synonym: "abnormal upregulation of transcription, DNA-dependent" EXACT [GO:0045893, PomBase:mah] is_a: FYPO:0000143 ! transcription regulation phenotype is_a: FYPO:0000628 ! abnormal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0045893 ! positive regulation of transcription, DNA-templated intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0045893 ! positive regulation of transcription, DNA-templated relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-19T03:38:05Z [Term] id: FYPO:0000624 name: abnormal negative regulation of transcription during vegetative growth def: "A transcription regulation phenotype observed in the vegetative growth phase of the life cycle in which any process of negative regulation of transcription is abnormal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. There may be enough evidence to support annotation to a more specific term such as 'abnormal chromatin silencing' (FYPO:0000144); if not, it is safer to annotate to 'increased transcription during vegetative growth' (FYPO:0000780) or 'decreased transcription during vegetative growth' (FYPO:0000781) rather than explicitly claiming that an effect on regulation was observed. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "abnormal down regulation of gene-specific transcription during vegetative growth" RELATED [GO:0045892, PomBase:mah] synonym: "abnormal down regulation of transcription, DNA-dependent, during vegetative growth" EXACT [GO:0045892, PomBase:mah] synonym: "abnormal down-regulation of gene-specific transcription during vegetative growth" RELATED [GO:0045892, PomBase:mah] synonym: "abnormal down-regulation of transcription, DNA-dependent, during vegetative growth" EXACT [GO:0045892, PomBase:mah] synonym: "abnormal downregulation of gene-specific transcription during vegetative growth" RELATED [GO:0045892, PomBase:mah] synonym: "abnormal downregulation of transcription, DNA-dependent, during vegetative growth" EXACT [GO:0045892, PomBase:mah] synonym: "abnormal inhibition of gene-specific transcription during vegetative growth" RELATED [GO:0045892, PomBase:mah] synonym: "abnormal inhibition of transcription, DNA-dependent, during vegetative growth" NARROW [GO:0045892, PomBase:mah] synonym: "abnormal negative regulation of cellular transcription, DNA-dependent, during vegetative growth" EXACT [GO:0045892, PomBase:mah] synonym: "abnormal negative regulation of gene-specific transcription during vegetative growth" RELATED [GO:0045892, PomBase:mah] synonym: "abnormal negative regulation of transcription during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal negative regulation of transcription, DNA-dependent, during vegetative growth" EXACT [GO:0045892, PomBase:mah] is_a: FYPO:0001335 ! transcription regulation phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0045892 ! negative regulation of transcription, DNA-templated intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0045892 ! negative regulation of transcription, DNA-templated relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-19T03:40:47Z [Term] id: FYPO:0000625 name: abnormal premeiotic DNA replication def: "A cellular process phenotype in which premeiotic DNA replication is abnormal." [PomBase:mah] synonym: "abnormal meiotic DNA replication" RELATED [GO:0006279, GOC:mah] synonym: "abnormal meiotic DNA synthesis" RELATED [GO:0006279, GOC:mah] synonym: "abnormal premeiotic DNA synthesis" RELATED [GO:0006279, GOC:mah] is_a: FYPO:0000217 ! abnormal DNA replication is_a: FYPO:0002739 ! abnormal meiotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0006279 ! premeiotic DNA replication intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0006279 ! premeiotic DNA replication relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-19T03:48:13Z [Term] id: FYPO:0000626 name: abnormal initiation of premeiotic DNA replication def: "A cellular process phenotype in which the initiation of premeiotic DNA replication is abnormal." [PomBase:mah] synonym: "abnormal initiation of meiotic DNA synthesis" RELATED [GO:0072691, GOC:mah] synonym: "abnormal initiation of premeiotic DNA synthesis" RELATED [GO:0072691, GOC:mah] synonym: "abnormal meiotic DNA replication initiation" RELATED [GO:0072691, GOC:mah] synonym: "abnormal premeiotic DNA replication initiation" EXACT [GO:0072691, GOC:mah] is_a: FYPO:0000176 ! abnormal DNA replication initiation is_a: FYPO:0000625 ! abnormal premeiotic DNA replication intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0072691 ! initiation of premeiotic DNA replication intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0072691 ! initiation of premeiotic DNA replication relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-19T03:49:02Z [Term] id: FYPO:0000627 name: normal cellular process def: "A phenotype in which a specific cellular process is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate is_a: FYPO:0000114 ! cellular process phenotype is_a: FYPO:0000257 ! normal phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0044763 ! single-organism cellular process intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0044763 ! single-organism cellular process relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-08-19T04:05:16Z [Term] id: FYPO:0000628 name: abnormal cellular process def: "A phenotype in which a specific cellular process is abnormal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate is_a: FYPO:0000114 ! cellular process phenotype is_a: FYPO:0003037 ! abnormal cell phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0044763 ! single-organism cellular process intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0044763 ! single-organism cellular process relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-19T04:06:34Z [Term] id: FYPO:0000629 name: abnormal apoptosis def: "A cellular process phenotype in which apoptosis is abnormal. Apoptosis is a form of cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies." [GO:0006915, PomBase:mah] is_a: FYPO:0000628 ! abnormal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0006915 ! apoptotic process intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0006915 ! apoptotic process relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-19T04:10:09Z [Term] id: FYPO:0000630 name: abnormal biofilm formation def: "A cellular process phenotype in which biofilm formation is abnormal." [PomBase:mah] is_a: FYPO:0000628 ! abnormal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0042710 ! biofilm formation intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0042710 ! biofilm formation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-08-19T04:12:58Z [Term] id: FYPO:0000631 name: cell cycle phenotype def: "A cellular process phenotype that affects progression of the mitotic or meiotic cell cycle, or regulation of cell cycle progression." [PomBase:mah] subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "cell-division cycle phenotype" EXACT [GO:0007049, PomBase:mah] synonym: "fission yeast cell cycle phenotype" EXACT [PomBase:mah] is_a: FYPO:0000114 ! cellular process phenotype intersection_of: FYPO:0000001 ! phenotype intersection_of: inheres_in_part_of GO:0007049 ! cell cycle relationship: inheres_in_part_of GO:0007049 ! cell cycle created_by: midori creation_date: 2011-08-19T04:16:04Z [Term] id: FYPO:0000632 name: mitochondrial translation phenotype def: "A cellular process phenotype that affects mitochondrial translation." [PomBase:mah] synonym: "fission yeast mitochondrial translation phenotype" EXACT [PomBase:mah] synonym: "mitochondrial translation phenotype during mitotic cell cycle" RELATED [PomBase:mah] synonym: "mitochondrial translation phenotype during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000291 ! translation phenotype is_a: FYPO:0000334 ! cellular component organization phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0032543 ! mitochondrial translation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0032543 ! mitochondrial translation created_by: midori creation_date: 2011-08-23T04:58:17Z [Term] id: FYPO:0000633 name: sensitive to G418 def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to G418. Cells stop growing (and may die) at a concentration of G418 that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to G418" EXACT [PomBase:mah] synonym: "sensitive to G418 during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to G418 during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to Geneticin" EXACT [CHEBI:42768, PomBase:al] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:42768 ! geneticin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:42768 ! geneticin created_by: midori creation_date: 2011-08-23T04:58:25Z [Term] id: FYPO:0000634 name: abolished protein localization to centromere def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the centromere of a chromosome does not occur." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to centromere" EXACT [PomBase:mah] synonym: "abolished protein localisation to chromosome, centromeric region" EXACT [GO:0071459, PomBase:mah] synonym: "abolished protein localization to centromere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to centromere during vegetative growth" EXACT [PomBase:mah] synonym: "abolished protein localization to chromosome, centric region" EXACT [GO:0071459, PomBase:mah] synonym: "abolished protein localization to chromosome, centromeric region" EXACT [GO:0071459, PomBase:mah] synonym: "protein absent from centromere" RELATED [PomBase:mah] synonym: "protein localization to centromere abolished" EXACT [PomBase:mah] is_a: FYPO:0000449 ! abnormal protein localization to centromere is_a: FYPO:0002841 ! abolished protein localization to chromosome intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0071459 ! protein localization to chromosome, centromeric region relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0071459 ! protein localization to chromosome, centromeric region created_by: midori creation_date: 2011-08-23T04:58:31Z [Term] id: FYPO:0000635 name: growth auxotrophic for leucine def: "Auxotrophy in which a cell is unable to synthesize leucine, and therefore requires leucine in the medium for vegetative cell growth." [PomBase:mah] synonym: "growth auxotrophic for leucine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "growth auxotrophic for leucine during vegetative growth" EXACT [PomBase:mah] synonym: "leucine auxotrophy" EXACT [PomBase:mah] is_a: FYPO:0000128 ! auxotrophy is_a: PATO:0000422 ! auxotrophic intersection_of: PATO:0000422 ! auxotrophic intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:15603 ! L-leucine relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:15603 ! L-leucine created_by: midori creation_date: 2011-08-23T05:17:07Z [Term] id: FYPO:0000636 name: increased cell population growth rate def: "A cell population phenotype in which a cell population in the vegetative growth phase of the life cycle grows at a faster rate than normal." [PomBase:mah] comment: Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "enhanced cell population growth" RELATED [PomBase:mah] synonym: "fast cell population growth" EXACT [PomBase:mah] synonym: "increased cell population growth rate during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cell population growth rate during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003937 ! increased cell population growth is_a: PATO:0000912 ! increased rate intersection_of: PATO:0000912 ! increased rate intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase created_by: midori creation_date: 2011-08-31T01:30:12Z [Term] id: FYPO:0000637 name: increased cell population growth rate on glucose carbon source def: "A cell population phenotype in which a cell population in the vegetative growth phase of the life cycle grows at a faster rate than normal in a medium containing glucose as the carbon source." [PomBase:mah] comment: Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "enhanced growth on glucose" RELATED [PomBase:mah] synonym: "fast cell population growth on glucose carbon source" EXACT [PomBase:mah] synonym: "increased vegetative cell population growth rate on glucose carbon source" EXACT [PomBase:mah] is_a: FYPO:0000636 ! increased cell population growth rate intersection_of: FYPO:0000636 ! increased cell population growth rate intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:17634 ! D-glucose relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:17634 ! D-glucose created_by: midori creation_date: 2011-08-31T02:20:29Z [Term] id: FYPO:0000639 name: delayed septation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which septation begins later than normal." [PomBase:al, PomBase:mah] synonym: "delayed barrier septum formation involved in mitotic cytokinesis" EXACT [PomBase:mah] synonym: "delayed mitotic barrier septum assembly" EXACT [GO:0000917, PomBase:mah] synonym: "delayed septation during vegetative growth" EXACT [PomBase:mah] synonym: "delayed septum formation" BROAD [PomBase:mah] is_a: FYPO:0000117 ! abnormal septation is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000917 ! barrier septum assembly relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000917 ! barrier septum assembly created_by: midori creation_date: 2011-08-31T02:55:54Z [Term] id: FYPO:0000640 name: abnormal chromatin silencing at centromere central core def: "A transcription regulation phenotype observed in the vegetative growth phase of the life cycle in which chromatin silencing at the central core of the centromeric regions is abnormal." [PomBase:mah] comment: Note that the centromere central core corresponds to SO:0001796. synonym: "abnormal centromere central core chromatin silencing" EXACT [PomBase:mah] synonym: "abnormal chromatin silencing at centromere central core during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal chromatin silencing at centromere central core during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal chromatin silencing at centromeric central core" EXACT [PomBase:mah] is_a: FYPO:0000146 ! abnormal chromatin silencing at centromere intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0072692 ! chromatin silencing at centromere central core intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0072692 ! chromatin silencing at centromere central core relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-09-12T03:33:40Z [Term] id: FYPO:0000641 name: abnormal chromosome organization def: "A cellular process phenotype in which any process of chromosome organization is abnormal. Chromosome organization results in the assembly, arrangement of constituent parts, or disassembly of chromosomes." [GO:0051276, PomBase:mah] comment: Consider annotating to 'abnormal chromosome morphology' (FYPO:0000848), but note that an abnormal chromosome organization process may, but does not necessarily, result in abnormal chromosome morphology. subset: qc_do_not_manually_annotate synonym: "abnormal chromosome organisation" EXACT [PomBase:mah] is_a: FYPO:0000335 ! abnormal cellular component organization intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0051276 ! chromosome organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0051276 ! chromosome organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-09-28T12:10:13Z [Term] id: FYPO:0000642 name: abnormal chromatin organization def: "A cellular process phenotype in which any process of chromatin organization is abnormal. Chromatin organization results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GO:0006325, PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "abnormal chromatin organisation" EXACT [PomBase:mah] is_a: FYPO:0000641 ! abnormal chromosome organization intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0006325 ! chromatin organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0006325 ! chromatin organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-09-28T12:16:57Z [Term] id: FYPO:0000643 name: abnormal mitotic DNA integrity checkpoint def: "A cell cycle checkpoint phenotype in which a mitotic DNA integrity checkpoint is abnormal. A DNA integrity checkpoint normally regulates cell cycle progression in response to changes in DNA structure. In a mutant, the checkpoint may fail to arrest or delay cell cycle progression under appropriate conditions, or the incidence or duration of arrest or delay may differ from wild type under any specified set of conditions." [PomBase:mah] synonym: "abnormal mitotic DNA integrity checkpoint activation" EXACT [PomBase:mah] is_a: FYPO:0001704 ! abnormal mitotic cell cycle checkpoint intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0044774 ! mitotic DNA integrity checkpoint intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0044774 ! mitotic DNA integrity checkpoint relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-09-28T12:28:26Z [Term] id: FYPO:0000644 name: normal protein localization during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which cellular protein localization is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal cellular protein localization" EXACT [PomBase:mah] synonym: "normal protein localisation during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein localization during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001319 ! normal cellular process during vegetative growth is_a: FYPO:0001337 ! localization phenotype during vegetative growth is_a: FYPO:0003627 ! normal protein localization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034613 ! cellular protein localization intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034613 ! cellular protein localization relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-10-05T04:52:48Z [Term] id: FYPO:0000645 name: small vegetative cell def: "A cell morphology phenotype in which a vegetative cell has an abnormally low volume." [PomBase:mah] is_a: FYPO:0000023 ! small cell is_a: FYPO:0001118 ! abnormal vegetative cell morphology intersection_of: PATO:0000596 ! decreased volume intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) created_by: midori creation_date: 2011-10-07T02:03:07Z [Term] id: FYPO:0000646 name: swollen vegetative cell def: "A cell morphology phenotype in which a vegetatively growing cell has a larger volume than normal. In a swollen cell, both length and diameter are greater than normal, although the cell is only considered elongated if the length:width ratio is also greater than normal." [PomBase:mah] synonym: "enlarged vegetative cell" RELATED [PomBase:mah] synonym: "increased vegetative cell size" RELATED [PomBase:vw] synonym: "increased vegetative cell volume" EXACT [PomBase:mah] synonym: "large vegetative cell" RELATED [PomBase:vw] is_a: FYPO:0000025 ! swollen cell is_a: FYPO:0001118 ! abnormal vegetative cell morphology intersection_of: PATO:0000595 ! increased volume intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) created_by: midori creation_date: 2011-10-07T04:19:54Z [Term] id: FYPO:0000647 name: vegetative cell lysis def: "An inviable phenotype in which a vegetative cell lyses, i.e. the plasma membrane ruptures and cytoplasm is lost. Note that in fission yeast cell lysis, the integrity of the cell wall is also compromised." [PomBase:mah] synonym: "cell lysis during vegetative growth" EXACT [PomBase:mah] synonym: "cytolysis during vegetative growth" EXACT [PomBase:mah] synonym: "inviable, lysed vegetative cell" EXACT [PomBase:mah] synonym: "vegetative cell lysis during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001320 ! vegetative cell phenotype is_a: FYPO:0002488 ! cell lysis intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0019835 ! cytolysis relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: inheres_in GO:0019835 ! cytolysis created_by: midori creation_date: 2011-10-10T03:28:02Z [Term] id: FYPO:0000648 name: viable small vegetative cell def: "A cell morphology phenotype in which a vegetatively growing cell is viable but has an abnormally low volume. Note that small viable cells result from a cell cycle size regulation defect." [PomBase:mah] comment: Also consider annotating to 'premature mitosis (FYPO:0001046), because small cells arise when mitosis takes place earlier than normal (i.e. at a smaller cell size). Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "mitosis with small cell size" RELATED [PomBase:vw] synonym: "reduced size at cell division" RELATED [PomBase:vw] synonym: "small viable vegetative cell" EXACT [PomBase:mah] synonym: "viable small cell during vegetative growth" EXACT [PomBase:mah] synonym: "viable small vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "wee" EXACT [PomBase:jh, PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000023 ! small cell intersection_of: has_part FYPO:0001491 ! viable vegetative cell intersection_of: inheres_in GO:0007067 ! mitotic nuclear division relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000023 ! small cell relationship: has_part FYPO:0001491 ! viable vegetative cell relationship: inheres_in GO:0007067 ! mitotic nuclear division created_by: midori creation_date: 2011-10-13T12:06:45Z [Term] id: FYPO:0000650 name: increased septation index def: "A cell population phenotype in which the septation index is higher than normal. The septation index is the proportion of the population undergoing septation at any given time, and is usually around 10% (varying between 7-15%) for wild type." [PomBase:mah, PomBase:vw] synonym: "increased number of septated cells" EXACT [PomBase:vw] synonym: "increased septation" RELATED [PomBase:mah] synonym: "septated" RELATED [PomBase:vw] is_a: FYPO:0000003 ! cell population phenotype is_a: FYPO:0001985 ! abnormal phenotype created_by: midori creation_date: 2011-10-13T12:34:42Z [Term] id: FYPO:0000651 name: increased duration of septation alt_id: FYPO:0000649 def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the duration of septation is increased." [PomBase:mah] synonym: "increased barrier septum formation involved in mitotic cytokinesis" RELATED [PomBase:mah] synonym: "increased duration of barrier septum formation involved in mitotic cytokinesis" EXACT [PomBase:mah] synonym: "increased duration of mitotic barrier septum assembly" EXACT [GO:0000917, PomBase:mah] synonym: "increased duration of septation during vegetative growth" EXACT [PomBase:mah] synonym: "increased duration of septum formation" BROAD [PomBase:mah] synonym: "increased septation" RELATED [PomBase:mah] synonym: "increased septum formation" RELATED [PomBase:mah] synonym: "prolonged septation" EXACT [PomBase:mah] is_a: FYPO:0000117 ! abnormal septation is_a: PATO:0000498 ! increased duration intersection_of: PATO:0000498 ! increased duration intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000917 ! barrier septum assembly relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000917 ! barrier septum assembly created_by: midori creation_date: 2011-10-13T03:07:53Z [Term] id: FYPO:0000652 name: molecular function phenotype def: "A phenotype that affects a molecular function such as binding or catalytic activity." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast molecular function phenotype" EXACT [PomBase:mah] synonym: "molecular function phenotype during mitotic cell cycle" RELATED [PomBase:mah] synonym: "molecular function phenotype during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000001 ! phenotype intersection_of: FYPO:0000001 ! phenotype intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0003674 ! molecular_function relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0003674 ! molecular_function created_by: midori creation_date: 2011-11-11T10:42:36Z [Term] id: FYPO:0000653 name: DNA binding phenotype def: "A phenotype that affects DNA binding. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast DNA binding phenotype" EXACT [PomBase:mah] is_a: FYPO:0001092 ! binding phenotype intersection_of: FYPO:0000001 ! phenotype intersection_of: inheres_in GO:0003677 ! DNA binding relationship: inheres_in GO:0003677 ! DNA binding created_by: midori creation_date: 2011-11-11T10:43:39Z [Term] id: FYPO:0000654 name: catalytic activity phenotype def: "A phenotype that affects a catalytic activity." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "enzymatic activity phenotype" EXACT [PomBase:mah] synonym: "fission yeast catalytic activity phenotype" EXACT [PomBase:mah] is_a: FYPO:0000652 ! molecular function phenotype intersection_of: FYPO:0000001 ! phenotype intersection_of: inheres_in GO:0003824 ! catalytic activity relationship: inheres_in GO:0003824 ! catalytic activity created_by: midori creation_date: 2011-11-11T10:44:09Z [Term] id: FYPO:0000655 name: normal DNA binding def: "A molecular function phenotype in which occurrence of DNA binding by a gene product is normal (i.e. indistinguishable from wild type). The relevant gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] is_a: FYPO:0000653 ! DNA binding phenotype is_a: FYPO:0000706 ! normal molecular function intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0003677 ! DNA binding intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0003677 ! DNA binding relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-11-11T10:45:30Z [Term] id: FYPO:0000656 name: abnormal DNA binding def: "A molecular function phenotype in which occurrence of DNA binding by a gene product is abnormal, when a gene or the bound DNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] is_a: FYPO:0000653 ! DNA binding phenotype is_a: FYPO:0000707 ! abnormal molecular function intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0003677 ! DNA binding intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0003677 ! DNA binding relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-11-11T10:45:30Z [Term] id: FYPO:0000657 name: increased DNA binding def: "A molecular function phenotype in which occurrence of DNA binding by a gene product is increased, when a gene or the bound DNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] is_a: FYPO:0000656 ! abnormal DNA binding is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0003677 ! DNA binding relationship: inheres_in GO:0003677 ! DNA binding created_by: midori creation_date: 2011-11-11T10:45:30Z [Term] id: FYPO:0000658 name: decreased DNA binding def: "A molecular function phenotype in which occurrence of DNA binding by a gene product is decreased, when a gene or the bound DNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "reduced DNA binding" EXACT [PomBase:mah] is_a: FYPO:0000656 ! abnormal DNA binding is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0003677 ! DNA binding relationship: inheres_in GO:0003677 ! DNA binding created_by: midori creation_date: 2011-11-11T10:45:30Z [Term] id: FYPO:0000659 name: abolished DNA binding def: "A molecular function phenotype in which DNA binding by a gene product does not occur, when a gene or the bound DNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "DNA binding abolished" EXACT [PomBase:mah] is_a: FYPO:0000656 ! abnormal DNA binding is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0003677 ! DNA binding relationship: towards GO:0003677 ! DNA binding created_by: midori creation_date: 2011-11-11T10:45:30Z [Term] id: FYPO:0000660 name: normal catalytic activity def: "A molecular function phenotype in which the observed rate of a specified catalytic activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000654 ! catalytic activity phenotype is_a: FYPO:0000706 ! normal molecular function intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0003824 ! catalytic activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0003824 ! catalytic activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-11-11T10:46:28Z [Term] id: FYPO:0000661 name: abnormal catalytic activity def: "A molecular function phenotype in which the observed rate or other catalytic property of a specified catalytic activity is abnormal." [PomBase:mah] is_a: FYPO:0000654 ! catalytic activity phenotype is_a: FYPO:0000707 ! abnormal molecular function intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0003824 ! catalytic activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0003824 ! catalytic activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-11-11T10:46:28Z [Term] id: FYPO:0000662 name: increased catalytic activity def: "A molecular function phenotype in which the observed rate of a specified catalytic activity is increased." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0003824 ! catalytic activity relationship: inheres_in GO:0003824 ! catalytic activity created_by: midori creation_date: 2011-11-11T10:46:28Z [Term] id: FYPO:0000663 name: decreased catalytic activity def: "A molecular function phenotype in which the observed rate of a specified catalytic activity is decreased." [PomBase:mah] synonym: "reduced catalytic activity" EXACT [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0003824 ! catalytic activity relationship: inheres_in GO:0003824 ! catalytic activity created_by: midori creation_date: 2011-11-11T10:46:28Z [Term] id: FYPO:0000664 name: abolished catalytic activity def: "A molecular function phenotype in which a specified catalytic activity is absent." [PomBase:mah] synonym: "catalytic activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0003824 ! catalytic activity relationship: towards GO:0003824 ! catalytic activity created_by: midori creation_date: 2011-11-11T10:46:28Z [Term] id: FYPO:0000665 name: normal peptidase activity def: "A molecular function phenotype in which the observed rate of a peptidase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal protease activity" EXACT [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0008233 ! peptidase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0008233 ! peptidase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-11-11T10:46:47Z [Term] id: FYPO:0000666 name: abnormal peptidase activity def: "A molecular function phenotype in which the observed rate of a peptidase activity is abnormal." [PomBase:mah] synonym: "abnormal protease activity" EXACT [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0008233 ! peptidase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0008233 ! peptidase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-11-11T10:46:47Z [Term] id: FYPO:0000667 name: increased peptidase activity def: "A molecular function phenotype in which the observed rate of a peptidase activity is increased." [PomBase:mah] synonym: "increased protease activity" EXACT [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0000666 ! abnormal peptidase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0008233 ! peptidase activity relationship: inheres_in GO:0008233 ! peptidase activity created_by: midori creation_date: 2011-11-11T10:46:47Z [Term] id: FYPO:0000668 name: decreased peptidase activity def: "A molecular function phenotype in which the observed rate of a peptidase activity is decreased." [PomBase:mah] synonym: "decreased protease activity" EXACT [PomBase:mah] synonym: "reduced peptidase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0000666 ! abnormal peptidase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0008233 ! peptidase activity relationship: inheres_in GO:0008233 ! peptidase activity created_by: midori creation_date: 2011-11-11T10:46:47Z [Term] id: FYPO:0000669 name: abolished peptidase activity def: "A molecular function phenotype in which a peptidase activity is absent." [PomBase:mah] synonym: "abolished protease activity" EXACT [PomBase:mah] synonym: "peptidase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0000666 ! abnormal peptidase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0008233 ! peptidase activity relationship: towards GO:0008233 ! peptidase activity created_by: midori creation_date: 2011-11-11T10:46:47Z [Term] id: FYPO:0000670 name: abnormal mitotic sister chromatid separation def: "A cellular process phenotype in which mitotic sister chromatid separation is abnormal. Mitotic sister chromatid separation is the process in which sister chromatids are physically detached from each other during mitosis." [GO:0051306, PomBase:mah] synonym: "abnormal mitotic chromosome separation" EXACT [PomBase:mah] synonym: "abnormal sister chromatid separation during vegetative growth" EXACT [PomBase:mah] synonym: "aneuploidy" RELATED [PomBase:vw] is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0002737 ! abnormal mitotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0051306 ! mitotic sister chromatid separation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0051306 ! mitotic sister chromatid separation relationship: part_of FYPO:0000141 ! abnormal mitotic sister chromatid segregation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-11-11T01:51:59Z [Term] id: FYPO:0000671 name: abnormal rDNA separation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitotic sister chromatid separation at the rDNA repeat regions is abnormal." [PomBase:mah] synonym: "abnormal mitotic sister chromatid separation at rDNA" EXACT [PomBase:mah] synonym: "abnormal rDNA separation during mitosis" EXACT [PomBase:mah] synonym: "abnormal rDNA separation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal rDNA separation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal ribosomal DNA separation" EXACT [PomBase:mah] synonym: "abnormal segregation of nucleolar rDNA" RELATED [PomBase:mah] is_a: FYPO:0000670 ! abnormal mitotic sister chromatid separation created_by: midori creation_date: 2011-11-11T01:59:59Z [Term] id: FYPO:0000672 name: normal cell morphology def: "A cell phenotype characterized by normal cell morphology (i.e. size, shape, and structure)." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "cellular morphology: normal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000136 ! cellular physical quality phenotype is_a: FYPO:0000257 ! normal phenotype is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: inheres_in CL:0000000 ! cell intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in CL:0000000 ! cell relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-11-11T02:51:12Z [Term] id: FYPO:0000673 name: normal septation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which septation is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal mitotic barrier septum assembly" EXACT [GO:0000917, PomBase:mah] synonym: "normal septation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002741 ! normal mitotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000917 ! barrier septum assembly intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000917 ! barrier septum assembly relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-11-11T02:53:07Z [Term] id: FYPO:0000674 name: normal cell population growth at high temperature def: "A cell population growth phenotype in which vegetative cells grow normally at a high temperature." [PomBase:mah] synonym: "heat sensitivity: normal" RELATED [SGD:phenotype_annotation] synonym: "normal growth at high temperature" BROAD [PomBase:mah] synonym: "normal vegetative cell population growth at high temperature" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0000047 ! normal cell population growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0001305 ! increased temperature relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0001305 ! increased temperature created_by: midori creation_date: 2011-11-11T02:55:04Z [Term] id: FYPO:0000675 name: abnormal protein targeting def: "A transport phenotype observed in the vegetative growth phase of the life cycle in which protein targeting is abnormal." [PomBase:mah] comment: Encompasses both targeting of proteins to a particular location where they are not normally found and decreased or no targeting of proteins normally found in the location. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein targeting during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein targeting during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000215 ! abnormal intracellular protein transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006605 ! protein targeting intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006605 ! protein targeting relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-11-11T03:24:12Z [Term] id: FYPO:0000676 name: abnormal protein targeting to vacuole def: "A transport phenotype observed in the vegetative growth phase of the life cycle in which protein targeting to the vacuole is abnormal." [PomBase:mah] comment: Encompasses both targeting of proteins to the vacuole where they are not normally found and decreased or no targeting of proteins normally found in the vacuole. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein targeting to vacuole during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein targeting to vacuole during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal vacuolar protein sorting" EXACT [PomBase:mah] is_a: FYPO:0000597 ! abnormal vacuolar transport during vegetative growth is_a: FYPO:0000675 ! abnormal protein targeting intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006623 ! protein targeting to vacuole intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006623 ! protein targeting to vacuole relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-11-11T03:25:01Z [Term] id: FYPO:0000677 name: abnormal protein localization to prospore membrane def: "A transport phenotype in which protein localization to the prospore membrane is abnormal." [PomBase:mah] comment: Encompasses both targeting of proteins to the prospore membrane where they are not normally found and decreased or no targeting of proteins normally found in the prospore membrane. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to prospore membrane" EXACT [PomBase:mah] synonym: "abnormal protein localization to forespore membrane" EXACT [PomBase:mah] is_a: FYPO:0001013 ! abnormal membrane organization is_a: FYPO:0001370 ! abnormal protein localization intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:1902657 ! protein localization to prospore membrane intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:1902657 ! protein localization to prospore membrane relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-11-29T05:16:27Z [Term] id: FYPO:0000678 name: unequal homologous chromosome segregation def: "A cellular process phenotype in which homologous chromosomes are not segregated equally to both spindle poles in the first meiotic nuclear division." [PomBase:mah] synonym: "chromosome nondisjunction at meiosis I" EXACT [PomBase:mah] synonym: "chromosome nondisjunction during meiosis I" EXACT [PomBase:mah] is_a: FYPO:0000925 ! unequal meiotic chromosome segregation is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0045143 ! homologous chromosome segregation relationship: towards GO:0045143 ! homologous chromosome segregation created_by: midori creation_date: 2011-11-29T05:44:25Z [Term] id: FYPO:0000679 name: developmental process phenotype def: "A phenotype that affects a developmental process." [PomBase:mah] synonym: "fission yeast developmental process phenotype" EXACT [PomBase:mah] is_a: FYPO:0000300 ! biological process phenotype intersection_of: FYPO:0000001 ! phenotype intersection_of: inheres_in_part_of GO:0032502 ! developmental process relationship: inheres_in_part_of GO:0032502 ! developmental process created_by: midori creation_date: 2011-11-29T06:02:16Z [Term] id: FYPO:0000680 name: abnormal ascus development def: "A developmental process phenotype in which ascus development is abnormal." [PomBase:mah] is_a: FYPO:0000679 ! developmental process phenotype is_a: FYPO:0001985 ! abnormal phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0075317 ! ascus development intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0075317 ! ascus development relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-11-29T06:03:31Z [Term] id: FYPO:0000681 name: abnormal sporulation resulting in formation of two-spore ascus def: "A sporulation phenotype that results in the formation of an ascus that has abnormal morphology and contains two diploid spores." [PMID:11156975, PomBase:mah, PomBase:vw] synonym: "abnormal ascospore formation resulting in formation of two-spore ascus" EXACT [GO:0030437, PomBase:mah] synonym: "abnormal sporulation resulting in formation of two-spore asci" EXACT [PomBase:mah] is_a: FYPO:0003066 ! abnormal sporulation resulting in formation of ascus with fewer than four spores created_by: midori creation_date: 2011-12-01T01:29:02Z [Term] id: FYPO:0000682 name: abnormal regulation of molecular function def: "A regulation phenotype observed in the vegetative growth phase of the life cycle in which regulation of a molecular function is abnormal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "abnormal regulation of molecular function during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal regulation of molecular function during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001334 ! regulation phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0065009 ! regulation of molecular function intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0065009 ! regulation of molecular function relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-12-01T01:43:05Z [Term] id: FYPO:0000683 name: constitutive catalytic activity def: "A regulation phenotype in which the basal activity of an enzyme is increased relative to normal. Basal enzyme activity is the activity observed in the absence of a regulator. Abnormally elevated basal activity may or may not reach the levels observed in the normal activated state." [PomBase:al, PomBase:mah] synonym: "constitutive catalytic activity during mitotic cell cycle" RELATED [PomBase:mah] synonym: "constitutive catalytic activity during vegetative growth" EXACT [PomBase:mah] synonym: "constitutive enzymatic activity" EXACT [PomBase:mah] synonym: "constitutively active enzyme" RELATED [PomBase:mah] is_a: FYPO:0000682 ! abnormal regulation of molecular function created_by: midori creation_date: 2011-12-01T01:51:53Z [Term] id: FYPO:0000684 name: decreased cell population growth on glycerol carbon source def: "A vegetative cell population growth phenotype in which cell growth is decreased relative to normal in a medium containing glycerol as the carbon source." [PomBase:al, PomBase:mah] comment: Note that trace amounts of another carbon source are usually required for S. pombe growth on glycerol; yeast extract-based rich medium supplies the trace substance, but minimal medium must be supplemented. It is therefore important to annotate the growth medium as an experimental condition when using this term. Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "decreased growth on glycerol carbon source" BROAD [PomBase:mah] synonym: "decreased vegetative cell growth on glycerol carbon source" EXACT [PomBase:mah] synonym: "reduced cell growth on glycerol carbon source" EXACT [PomBase:mah] synonym: "slow cell growth on glycerol carbon source" NARROW [PomBase:mah] is_a: FYPO:0001355 ! decreased vegetative cell population growth intersection_of: FYPO:0000046 ! decreased cell population growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:17754 ! glycerol relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:17754 ! glycerol created_by: midori creation_date: 2011-12-01T04:41:03Z [Term] id: FYPO:0000685 name: transcriptional response to pheromone at decreased pheromone level def: "A cellular response phenotype in which pheromone-responsive positive regulation of transcription from an RNA polymerase II promoter occurs at a lower level of pheromone than normal." [PomBase:mah] comment: This term was made obsolete because it has a confusing name and represents a non-useful distinction. synonym: "increased sensitivity of positive regulation of transcription from RNA polymerase II promoter by pheromones to pheromone" RELATED [PomBase:mah] synonym: "increased transcriptional response to pheromone" RELATED [PomBase:mah] synonym: "positive regulation of transcription from RNA polymerase II promoter by pheromones at decreased pheromone level" EXACT [GO:0007329, PomBase:mah] synonym: "sensitive to pheromone" RELATED [PomBase:al, PomBase:mah] is_obsolete: true created_by: midori creation_date: 2011-12-01T04:46:17Z [Term] id: FYPO:0000686 name: normal peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity def: "A molecular function phenotype in which the observed rate of peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0000224 ! peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0000224 ! peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-12-01T05:15:00Z [Term] id: FYPO:0000687 name: abnormal peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity def: "A molecular function phenotype in which the observed rate of peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0000224 ! peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0000224 ! peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-12-01T05:15:00Z [Term] id: FYPO:0000688 name: decreased peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity def: "A molecular function phenotype in which the observed rate of peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity is decreased." [PomBase:mah] synonym: "reduced peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0000687 ! abnormal peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0000224 ! peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity relationship: inheres_in GO:0000224 ! peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity created_by: midori creation_date: 2011-12-01T05:15:00Z [Term] id: FYPO:0000689 name: abnormal oxidoreductase activity def: "A molecular function phenotype in which the observed rate of an oxidoreductase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0016491 ! oxidoreductase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0016491 ! oxidoreductase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-12-01T05:15:00Z [Term] id: FYPO:0000690 name: decreased oxidoreductase activity def: "A molecular function phenotype in which the observed rate of an oxidoreductase activity is decreased." [PomBase:mah] synonym: "reduced oxidoreductase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0000689 ! abnormal oxidoreductase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0016491 ! oxidoreductase activity relationship: inheres_in GO:0016491 ! oxidoreductase activity created_by: midori creation_date: 2011-12-01T05:15:00Z [Term] id: FYPO:0000691 name: normal DNA-1,N6-ethenoadenine N-glycosylase activity def: "A molecular function phenotype in which the observed rate of DNA-1,N6-ethenoadenine N-glycosylase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0052820 ! DNA-1,N6-ethenoadenine N-glycosylase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0052820 ! DNA-1,N6-ethenoadenine N-glycosylase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-12-01T05:15:00Z [Term] id: FYPO:0000692 name: abnormal DNA-1,N6-ethenoadenine N-glycosylase activity def: "A molecular function phenotype in which the observed rate of DNA-1,N6-ethenoadenine N-glycosylase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0052820 ! DNA-1,N6-ethenoadenine N-glycosylase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0052820 ! DNA-1,N6-ethenoadenine N-glycosylase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-12-01T05:15:00Z [Term] id: FYPO:0000693 name: decreased DNA-1,N6-ethenoadenine N-glycosylase activity def: "A molecular function phenotype in which the observed rate of DNA-1,N6-ethenoadenine N-glycosylase activity is decreased." [PomBase:mah] synonym: "reduced DNA-1,N6-ethenoadenine N-glycosylase activity" EXACT [PomBase:al] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0000692 ! abnormal DNA-1,N6-ethenoadenine N-glycosylase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0052820 ! DNA-1,N6-ethenoadenine N-glycosylase activity relationship: inheres_in GO:0052820 ! DNA-1,N6-ethenoadenine N-glycosylase activity created_by: midori creation_date: 2011-12-01T05:15:00Z [Term] id: FYPO:0000694 name: abolished DNA-1,N6-ethenoadenine N-glycosylase activity def: "A molecular function phenotype in which DNA-1,N6-ethenoadenine N-glycosylase activity is absent." [PomBase:mah] synonym: "DNA-1,N6-ethenoadenine N-glycosylase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0000692 ! abnormal DNA-1,N6-ethenoadenine N-glycosylase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0052820 ! DNA-1,N6-ethenoadenine N-glycosylase activity relationship: towards GO:0052820 ! DNA-1,N6-ethenoadenine N-glycosylase activity created_by: midori creation_date: 2011-12-01T05:15:00Z [Term] id: FYPO:0000695 name: increased DNA-1,N6-ethenoadenine N-glycosylase activity def: "A molecular function phenotype in which the observed rate of DNA-1,N6-ethenoadenine N-glycosylase activity is increased." [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0000692 ! abnormal DNA-1,N6-ethenoadenine N-glycosylase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0052820 ! DNA-1,N6-ethenoadenine N-glycosylase activity relationship: inheres_in GO:0052820 ! DNA-1,N6-ethenoadenine N-glycosylase activity created_by: midori creation_date: 2011-12-01T05:15:00Z [Term] id: FYPO:0000696 name: normal DNA-7-methylguanine glycosylase activity def: "A molecular function phenotype in which the observed rate of DNA-7-methylguanine glycosylase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0043916 ! DNA-7-methylguanine glycosylase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0043916 ! DNA-7-methylguanine glycosylase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-12-01T05:15:00Z [Term] id: FYPO:0000697 name: abnormal DNA-7-methylguanine glycosylase activity def: "A molecular function phenotype in which the observed rate of DNA-7-methylguanine glycosylase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0043916 ! DNA-7-methylguanine glycosylase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0043916 ! DNA-7-methylguanine glycosylase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-12-01T05:15:00Z [Term] id: FYPO:0000698 name: decreased DNA-7-methylguanine glycosylase activity def: "A molecular function phenotype in which the observed rate of DNA-7-methylguanine glycosylase activity is decreased." [PomBase:mah] synonym: "reduced DNA-7-methylguanine glycosylase activity" EXACT [PomBase:al] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0000697 ! abnormal DNA-7-methylguanine glycosylase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0043916 ! DNA-7-methylguanine glycosylase activity relationship: inheres_in GO:0043916 ! DNA-7-methylguanine glycosylase activity created_by: midori creation_date: 2011-12-01T05:15:00Z [Term] id: FYPO:0000699 name: abolished DNA-7-methylguanine glycosylase activity def: "A molecular function phenotype in which DNA-7-methylguanine glycosylase activity is absent." [PomBase:mah] synonym: "DNA-7-methylguanine glycosylase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0000697 ! abnormal DNA-7-methylguanine glycosylase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0043916 ! DNA-7-methylguanine glycosylase activity relationship: towards GO:0043916 ! DNA-7-methylguanine glycosylase activity created_by: midori creation_date: 2011-12-01T05:15:00Z [Term] id: FYPO:0000700 name: increased DNA-7-methylguanine glycosylase activity def: "A molecular function phenotype in which the observed rate of DNA-7-methylguanine glycosylase activity is increased." [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0000697 ! abnormal DNA-7-methylguanine glycosylase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0043916 ! DNA-7-methylguanine glycosylase activity relationship: inheres_in GO:0043916 ! DNA-7-methylguanine glycosylase activity created_by: midori creation_date: 2011-12-01T05:15:00Z [Term] id: FYPO:0000701 name: abolished DNA damage checkpoint override in response to caffeine def: "A cellular response phenotype in which caffeine does not override the DNA damage checkpoint (as it does in wild type cells), allowing mitotic cell cycle arrest to occur." [PMID:10224243, PomBase:mah] synonym: "abolished DNA damage checkpoint override in response to caffeine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "caffeine-mediated DNA damage checkpoint override abolished" EXACT [GOC:mah, GOC:vw] synonym: "DNA damage checkpoint override in response to caffeine abolished" EXACT [PomBase:mah] synonym: "DNA damage checkpoint override in response to caffeine abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000207 ! abnormal cellular response to caffeine is_a: FYPO:0001704 ! abnormal mitotic cell cycle checkpoint created_by: midori creation_date: 2011-12-05T01:59:12Z [Term] id: FYPO:0000702 name: protein binding phenotype def: "A phenotype that protein affects the binding of one protein to another. The relevant proteins may include the one encoded by the mutated gene, or may both be encoded by different genes." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast protein binding phenotype" EXACT [PomBase:mah] is_a: FYPO:0001092 ! binding phenotype intersection_of: FYPO:0000001 ! phenotype intersection_of: inheres_in GO:0005515 ! protein binding relationship: inheres_in GO:0005515 ! protein binding created_by: midori creation_date: 2011-12-05T02:24:49Z [Term] id: FYPO:0000703 name: normal protein binding def: "A molecular function phenotype in which the binding of one protein to another is normal (i.e. indistinguishable from wild type). The relevant proteins may include the one encoded by the mutated gene, or may both be encoded by different genes." [PomBase:mah] comment: This term can be used for any protein-protein interaction that is tested in a mutant, whether or not the mutated gene product is one of the interacting proteins. We recommend noting which proteins were used in the assay when annotating to this term. synonym: "normal protein-protein interaction" EXACT [PomBase:mah] is_a: FYPO:0000702 ! protein binding phenotype is_a: FYPO:0000706 ! normal molecular function intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0005515 ! protein binding intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0005515 ! protein binding relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-12-05T02:25:15Z [Term] id: FYPO:0000704 name: abnormal protein binding def: "A molecular function phenotype in which the binding of one protein to another is abnormal. The relevant proteins may include the one encoded by the mutated gene, or may both be encoded by different genes." [PomBase:mah] comment: This term can be used for any protein-protein interaction that is affected by a mutation, whether or not the mutated gene product is one of the interacting proteins. We recommend noting which proteins were used in the assay when annotating to this term. synonym: "abnormal protein-protein interaction" EXACT [PomBase:mah] is_a: FYPO:0000702 ! protein binding phenotype is_a: FYPO:0000707 ! abnormal molecular function intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0005515 ! protein binding intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0005515 ! protein binding relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-12-05T02:25:58Z [Term] id: FYPO:0000705 name: abolished protein binding def: "A molecular function phenotype in which the binding of one protein to another does not occur. The relevant proteins may include the one encoded by the mutated gene, or may both be encoded by different genes." [PomBase:mah] comment: This term can be used for any protein-protein interaction that is affected by a mutation, whether or not the mutated gene product is one of the interacting proteins. We recommend noting which proteins were used in the assay when annotating to this term. synonym: "abolished protein-protein interaction" EXACT [PomBase:mah] synonym: "protein binding abolished" EXACT [PomBase:mah] is_a: FYPO:0000704 ! abnormal protein binding is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0005515 ! protein binding relationship: towards GO:0005515 ! protein binding created_by: midori creation_date: 2011-12-05T02:26:17Z [Term] id: FYPO:0000706 name: normal molecular function def: "A phenotype in which a specific molecular function is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_a: FYPO:0000257 ! normal phenotype is_a: FYPO:0000652 ! molecular function phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0003674 ! molecular_function intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0003674 ! molecular_function relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-12-05T03:06:23Z [Term] id: FYPO:0000707 name: abnormal molecular function def: "A phenotype in which a specific molecular function is abnormal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_a: FYPO:0000652 ! molecular function phenotype is_a: FYPO:0001985 ! abnormal phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0003674 ! molecular_function intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0003674 ! molecular_function relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-12-05T03:09:24Z [Term] id: FYPO:0000708 name: decreased mating efficiency def: "A biological process phenotype in which the observed mating efficiency is lower than normal." [PMID:15300681, PMID:16598689, PomBase:al, PomBase:mah] comment: Note that mating efficiency is often measured by counting zygotes plus asci, sometimes also including spores, so a change in measured mating efficiency may reflect a change in conjugation frequency (see FYPO:0000031 and its descendants), a change in sporulation (see FYPO:0000121 and its descendants), or both. For this reason, this term is not a child of 'mating phenotype' (FYPO:0000031). synonym: "mating efficiency: decreased" EXACT [SGD:phenotype_annotation] synonym: "reduced mating efficiency" EXACT [PomBase:mah] is_a: FYPO:0000003 ! cell population phenotype created_by: midori creation_date: 2011-12-05T04:26:20Z [Term] id: FYPO:0000709 name: decreased cell population growth during nitrogen starvation alt_id: FYPO:0002124 def: "A cell growth phenotype in which cell population growth is decreased relative to normal under nitrogen starvation conditions, such as in nitrogen-deficient minimal medium." [PomBase:mah] comment: Use this term if you have assayed growth of cells exposed to nitrogen starvation in culture. If you have assayed the response to nitrogen starvation at the subcellular or molecular level, consider annotating to 'abnormal cellular response to nitrogen starvation' (FYPO:0000152). Also note that this term can be used for any circumstances in which cells are starved for nitrogen. Cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation, but this term is not restricted to G0. Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "decreased cell population growth during nitrogen depletion" EXACT [PomBase:vw] synonym: "decreased cell population growth during nitrogen deprivation" EXACT [PomBase:vw] synonym: "decreased cell population growth in response to nitrogen starvation" EXACT [PomBase:mah] synonym: "hypersensitive to nitrogen starvation" RELATED [PomBase:mah] synonym: "reduced cell population growth during nitrogen starvation" RELATED [PomBase:mah] synonym: "sensitive to nitrogen depletion" RELATED [PomBase:vw] synonym: "sensitive to nitrogen deprivation" RELATED [PomBase:vw] synonym: "sensitive to nitrogen starvation" RELATED [PomBase:mah] synonym: "slow cell population growth during nitrogen starvation" NARROW [PomBase:mah] synonym: "slow cell population growth in nitrogen-deficient minimal medium" RELATED [PomBase:al, PomBase:mah] synonym: "slow growth during nitrogen starvation" BROAD [PomBase:mah] is_a: FYPO:0000046 ! decreased cell population growth intersection_of: FYPO:0000046 ! decreased cell population growth intersection_of: happens_during GO:0006995 ! cellular response to nitrogen starvation relationship: happens_during GO:0006995 ! cellular response to nitrogen starvation created_by: midori creation_date: 2011-12-05T04:43:53Z [Term] id: FYPO:0000710 name: abnormal mitotic cell cycle arrest in response to nitrogen starvation def: "A cellular process phenotype in which mitotic cell cycle arrest in response to nitrogen starvation, which normally occurs in G1 phase, is abnormal." [PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "abnormal mitotic cell cycle arrest in response to nitrogen depletion" EXACT [PomBase:vw] synonym: "abnormal mitotic cell cycle arrest in response to nitrogen deprivation" EXACT [PomBase:vw] is_a: FYPO:0000152 ! abnormal cellular response to nitrogen starvation is_a: FYPO:0001026 ! abnormal occurrence of normal mitotic cell cycle arrest intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0030996 ! mitotic cell cycle arrest in response to nitrogen starvation intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0030996 ! mitotic cell cycle arrest in response to nitrogen starvation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-12-06T12:15:03Z [Term] id: FYPO:0000711 name: decreased cell cycle arrest in mitotic G1 phase in response to nitrogen starvation def: "A cellular process phenotype in which cell cycle arrest in response to nitrogen starvation occurs in G1 phase, but its occurrence is decreased." [PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "decreased cell cycle arrest in mitotic G1 phase during cellular response to nitrogen starvation" EXACT [PomBase:mah] synonym: "decreased cell cycle arrest in mitotic G1 phase in response to nitrogen depletion" EXACT [PomBase:vw] synonym: "decreased cell cycle arrest in mitotic G1 phase in response to nitrogen deprivation" EXACT [PomBase:vw] synonym: "decreased mitotic cell cycle arrest in G1 phase in response to nitrogen starvation" EXACT [PomBase:mah] synonym: "decreased mitotic G1 arrest in response to nitrogen starvation" EXACT [PomBase:mah] synonym: "decreased nitrogen deprivation-induced G1 arrest" EXACT [PomBase:vw] synonym: "reduced cell cycle arrest in mitotic G1 phase in response to nitrogen starvation" EXACT [PomBase:mah] is_a: FYPO:0000445 ! cell cycle arrest in mitotic G1 phase is_a: FYPO:0000710 ! abnormal mitotic cell cycle arrest in response to nitrogen starvation is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0030996 ! mitotic cell cycle arrest in response to nitrogen starvation relationship: inheres_in GO:0030996 ! mitotic cell cycle arrest in response to nitrogen starvation created_by: midori creation_date: 2011-12-06T12:15:32Z [Term] id: FYPO:0000712 name: delayed cell cycle arrest in mitotic G1 phase in response to nitrogen starvation def: "A cellular process phenotype in which the occurrence of cell cycle arrest in response to nitrogen starvation occurs in G1 phase, but begins later than normal." [PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "delayed cell cycle arrest in mitotic G1 phase during cellular response to nitrogen starvation" EXACT [PomBase:mah] synonym: "delayed cell cycle arrest in mitotic G1 phase in response to nitrogen depletion" EXACT [PomBase:vw] synonym: "delayed cell cycle arrest in mitotic G1 phase in response to nitrogen deprivation" EXACT [PomBase:vw] synonym: "delayed mitotic cell cycle arrest in G1 phase in response to nitrogen starvation" EXACT [PomBase:mah] synonym: "delayed mitotic G1 arrest in response to nitrogen starvation" EXACT [PomBase:mah] synonym: "delayed nitrogen deprivation-induced G1 arrest" EXACT [PomBase:vw] is_a: FYPO:0000445 ! cell cycle arrest in mitotic G1 phase is_a: FYPO:0000710 ! abnormal mitotic cell cycle arrest in response to nitrogen starvation is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: inheres_in GO:0030996 ! mitotic cell cycle arrest in response to nitrogen starvation relationship: inheres_in GO:0030996 ! mitotic cell cycle arrest in response to nitrogen starvation created_by: midori creation_date: 2011-12-06T12:16:53Z [Term] id: FYPO:0000713 name: abnormal cellular response to starvation def: "A stress response phenotype in which the response to starvation for one or more nutrients is abnormal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "abnormal cellular response to depletion" EXACT [PomBase:vw] synonym: "abnormal cellular response to deprivation" EXACT [PomBase:vw] is_a: FYPO:0000162 ! abnormal cellular response to stress intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0009267 ! cellular response to starvation intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0009267 ! cellular response to starvation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-12-06T12:25:40Z [Term] id: FYPO:0000714 name: sensitive to leptomycin B def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to leptomycin B. Cells stop growing (and may die) at a concentration of leptomycin B that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to leptomycin B" EXACT [PomBase:mah] synonym: "sensitive to leptomycin B during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to leptomycin B during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to LMB" EXACT [CHEBI:52646, PomBase:al] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:52646 ! leptomycin B relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:52646 ! leptomycin B created_by: midori creation_date: 2011-12-06T12:31:38Z [Term] id: FYPO:0000715 name: sensitive to K-252a def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to K-252a. Cells stop growing (and may die) at a concentration of K-252a that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to K-252a" EXACT [PomBase:mah] synonym: "sensitive to K-252a during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to K-252a during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:43616 ! K-252a relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:43616 ! K-252a created_by: midori creation_date: 2011-12-06T12:31:38Z [Term] id: FYPO:0000716 name: sensitive to valinomycin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to valinomycin. Cells stop growing (and may die) at a concentration of valinomycin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to valinomycin" EXACT [PomBase:mah] synonym: "sensitive to valinomycin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to valinomycin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:28545 ! valinomycin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:28545 ! valinomycin created_by: midori creation_date: 2011-12-06T12:31:38Z [Term] id: FYPO:0000717 name: sensitive to actinomycin D def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to actinomycin D. Cells stop growing (and may die) at a concentration of actinomycin D that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to actinomycin D" EXACT [PomBase:mah] synonym: "sensitive to actinomycin D during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to actinomycin D during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:27666 ! actinomycin D relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:27666 ! actinomycin D created_by: midori creation_date: 2011-12-06T12:31:38Z [Term] id: FYPO:0000718 name: sensitive to trisodium vanadate def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to trisodium vanadate (also known as sodium orthovanadate). Cells stop growing (and may die) at a concentration of trisodium vanadate that allows wild type cells to grow." [PomBase:mah] comment: Also see 'sensitive to vanadate' (FYPO:0003656). synonym: "hypersensitive to trisodium vanadate" EXACT [PomBase:mah] synonym: "sensitive to sodium orthovanadate" EXACT [CHEBI:35607, PomBase:al] synonym: "sensitive to trisodium vanadate during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to trisodium vanadate during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:35607 ! trisodium vanadate relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:35607 ! trisodium vanadate created_by: midori creation_date: 2011-12-06T12:31:38Z [Term] id: FYPO:0000719 name: normal fatty acid synthase activity def: "A molecular function phenotype in which the observed rate of fatty acid synthase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal FAS activity" EXACT [PomBase:al, PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004312 ! fatty acid synthase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0004312 ! fatty acid synthase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2011-12-06T01:43:30Z [Term] id: FYPO:0000720 name: abnormal fatty acid synthase activity def: "A molecular function phenotype in which the observed rate of fatty acid synthase activity is abnormal." [PomBase:mah] synonym: "abnormal FAS activity" EXACT [PomBase:al, PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004312 ! fatty acid synthase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004312 ! fatty acid synthase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-12-06T01:57:58Z [Term] id: FYPO:0000721 name: abnormal cellular response to pH def: "A cellular response phenotype observed in the vegetative growth phase of the life cycle in which the cellular response to a pH stimulus is abnormal." [PomBase:mah] synonym: "abnormal cellular response to pH during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal cellular response to pH during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001342 ! cellular response phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0071467 ! cellular response to pH intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0071467 ! cellular response to pH relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-12-06T02:45:18Z [Term] id: FYPO:0000722 name: sensitive to acidity def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to acidic pH. Cells stop growing (and may die) at a pH that allows wild type cells to grow." [PomBase:mah] comment: In chemistry, acid pH is below 7.0. This term, however, is most useful for annotating phenotypes observed at any pH lower than that of standard fission yeast media, about 5.8. Also see 'sensitive to low pH' (FYPO:0001989). synonym: "acid pH resistance: decreased" EXACT [SGD:phenotype_annotation] synonym: "hypersensitive to acidity" EXACT [PomBase:mah] synonym: "sensitive to acidity during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to acidity during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000304 ! sensitive to stress during vegetative growth created_by: midori creation_date: 2011-12-06T02:47:00Z [Term] id: FYPO:0000723 name: sensitive to alkalinity def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to alkaline pH. Cells stop growing (and may die) at a pH that allows wild type cells to grow." [PomBase:mah] comment: In chemistry, alkaline pH is over 7.0. This term, however, is most useful for annotating phenotypes observed at any pH higher than that of standard fission yeast media, about 5.8. Also see 'sensitive to high pH' (FYPO:0001987). synonym: "alkaline pH resistance: decreased" EXACT [SGD:phenotype_annotation] synonym: "hypersensitive to alkalinity" EXACT [PomBase:mah] synonym: "sensitive to alkalinity during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to alkalinity during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000304 ! sensitive to stress during vegetative growth created_by: midori creation_date: 2011-12-06T02:48:18Z [Term] id: FYPO:0000724 name: resistance to N-methyl-N'-nitro-N-nitrosoguanidine def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of N-methyl-N'-nitro-N-nitrosoguanidine than normal." [PomBase:mah] synonym: "resistance to methylnitronitrosoguanidine" EXACT [CHEBI:21759] synonym: "resistance to N-methyl-N'-nitro-N-nitrosoguanidine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to N-methyl-N'-nitro-N-nitrosoguanidine during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to MNNG" EXACT [CHEBI:21759] synonym: "resistant to N-methyl-N'-nitro-N-nitrosoguanidine" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:21759 ! N-methyl-N'-nitro-N-nitrosoguanidine relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:21759 ! N-methyl-N'-nitro-N-nitrosoguanidine created_by: midori creation_date: 2011-12-06T04:17:30Z [Term] id: FYPO:0000725 name: resistance to methyl methanesulfonate def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of methyl methanesulfonate than normal." [PomBase:mah] synonym: "resistance to methyl methanesulfonate during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to methyl methanesulfonate during vegetative growth" EXACT [PomBase:mah] synonym: "resistance to methyl methanesulphonate" EXACT [PomBase:mah] synonym: "resistance to MMS" EXACT [PomBase:mah] synonym: "resistant to methyl methanesulfonate" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:25255 ! methyl methanesulfonate relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:25255 ! methyl methanesulfonate created_by: midori creation_date: 2011-12-07T11:28:32Z [Term] id: FYPO:0000726 name: sensitive to oxidative stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to oxidative stress." [PomBase:mah] comment: Use this term if you have assayed growth of cells exposed to oxidative stress in culture. If you have assayed the response to oxidative stress at the subcellular or molecular level, consider annotating to 'abnormal cellular response to oxidative stress during vegetative growth' (FYPO:0001340). synonym: "hypersensitive to oxidative stress" EXACT [PomBase:mah] synonym: "oxidative stress resistance: decreased" EXACT [SGD:phenotype_annotation] synonym: "sensitive to oxidative stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to oxidative stress during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000304 ! sensitive to stress during vegetative growth created_by: midori creation_date: 2011-12-07T01:17:37Z [Term] id: FYPO:0000727 name: abnormal actin filament organization during vegetative growth def: "A cytokinesis phenotype observed in the vegetative growth phase of the life cycle in which the assembly and distribution of cytoskeletal structures comprising actin filaments does not occur normally." [GO:0007015, PomBase:mah] synonym: "abnormal actin filament organisation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal actin filament organization during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000801 ! abnormal actin cytoskeleton organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0007015 ! actin filament organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0007015 ! actin filament organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-12-07T02:53:31Z [Term] id: FYPO:0000728 name: abnormal actin cortical patch assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which actin cortical patch assembly is abnormal." [PomBase:mah] synonym: "abnormal actin cortical patch assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal actin cortical patch assembly during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000790 ! abnormal actin cortical patch organization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000147 ! actin cortical patch assembly intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000147 ! actin cortical patch assembly relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-12-07T03:02:33Z [Term] id: FYPO:0000729 name: delayed actomyosin contractile ring assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which contractile ring assembly begins later than normal." [PomBase:mah] synonym: "delayed actomyosin contractile ring assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "delayed actomyosin contractile ring assembly during vegetative growth" EXACT [PomBase:mah] synonym: "delayed actomyosin contractile ring formation" RELATED [GO:0000915, PomBase:vw] synonym: "delayed contractile ring assembly" EXACT [PomBase:mah] synonym: "delayed cytokinetic contractile ring assembly" EXACT [PomBase:vw] synonym: "delayed cytokinetic ring assembly" RELATED [PomBase:vw] synonym: "delayed cytokinetic ring formation" RELATED [PomBase:vw] synonym: "delayed mitotic contractile ring assembly" EXACT [PomBase:vw] is_a: FYPO:0000161 ! abnormal actomyosin contractile ring assembly is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000915 ! actomyosin contractile ring assembly relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000915 ! actomyosin contractile ring assembly created_by: midori creation_date: 2011-12-07T04:50:03Z [Term] id: FYPO:0000730 name: long spindle def: "A spindle phenotype in which the spindle is longer than normal." [PomBase:mah] synonym: "elongated spindle" EXACT [PomBase:mah] synonym: "increased spindle length" EXACT [PomBase:mah] synonym: "long spindles" EXACT [PomBase:mah] is_a: FYPO:0003607 ! abnormal spindle morphology is_a: PATO:0000573 ! increased length intersection_of: PATO:0000573 ! increased length intersection_of: inheres_in GO:0005819 ! spindle relationship: inheres_in GO:0005819 ! spindle created_by: midori creation_date: 2011-12-07T04:51:57Z [Term] id: FYPO:0000731 name: abnormal protein localization to medial cortex during vegetative growth def: "A cell phenotype in which the localization of a protein to the medial cortex is abnormal in the vegetative growth phase of the life cycle." [PomBase:mah] comment: Encompasses both presence of proteins not normally found at the medial cortex and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to medial cortex during vegetative growth" EXACT [GO:0071574, PomBase:mah] synonym: "abnormal protein localization to medial cortex during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein localization to medial ring during vegetative growth" EXACT [GO:0031097, GO:0071574] is_a: FYPO:0000928 ! abnormal protein localization to cell cortex is_a: FYPO:0001373 ! abnormal protein localization to medial cortex is_a: FYPO:0001401 ! abnormal protein localization to cell division site intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0071574 ! protein localization to medial cortex intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0071574 ! protein localization to medial cortex relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2011-12-07T05:16:57Z [Term] id: FYPO:0000732 name: short mitotic spindle def: "A spindle phenotype in which the mitotic spindle is shorter than normal." [PomBase:mah] comment: Note that short mitotic spindles are usually not parallel to the long axis of the cell, because short spindle formation takes place before spindle orientation is established (see GO:0000132). synonym: "decreased mitotic spindle length" EXACT [PomBase:mah] synonym: "short bipolar mitotic spindle" EXACT [PomBase:vw] synonym: "short mitotic spindle during vegetative growth" EXACT [PomBase:mah] synonym: "short mitotic spindles" EXACT [PomBase:mah] synonym: "short spindle during mitosis" EXACT [PomBase:mah] is_a: FYPO:0000130 ! short spindle is_a: FYPO:0001574 ! abnormal bipolar mitotic spindle intersection_of: PATO:0000574 ! decreased length intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072686 ! mitotic spindle relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072686 ! mitotic spindle created_by: midori creation_date: 2012-01-11T11:30:01Z [Term] id: FYPO:0000733 name: long mitotic spindle def: "A spindle phenotype in which the mitotic spindle is longer than normal." [PomBase:mah] synonym: "elongated mitotic spindle" EXACT [PomBase:mah] synonym: "increased mitotic spindle length" EXACT [PomBase:vw] synonym: "long bipolar mitotic spindle" EXACT [PomBase:vw] synonym: "long mitotic spindle during vegetative growth" EXACT [PomBase:mah] synonym: "long mitotic spindles" EXACT [PomBase:mah] synonym: "long spindle during mitosis" EXACT [PomBase:mah] is_a: FYPO:0000730 ! long spindle is_a: FYPO:0001574 ! abnormal bipolar mitotic spindle intersection_of: PATO:0000573 ! increased length intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072686 ! mitotic spindle relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072686 ! mitotic spindle created_by: midori creation_date: 2012-01-11T11:30:01Z [Term] id: FYPO:0000734 name: abnormal meiotic spindle def: "A physical cellular phenotype in which the structure of the meiotic spindle is abnormal." [PomBase:mah] is_a: FYPO:0000120 ! abnormal spindle intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0072687 ! meiotic spindle intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0072687 ! meiotic spindle relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-01-11T11:30:13Z [Term] id: FYPO:0000735 name: short meiotic spindle def: "A spindle phenotype in which the meiotic spindle is shorter than normal." [PomBase:mah] synonym: "decreased meiotic spindle length" EXACT [PomBase:mah] synonym: "short meiotic spindles" EXACT [PomBase:mah] synonym: "short spindle during meiosis" EXACT [PomBase:mah] is_a: FYPO:0000130 ! short spindle is_a: FYPO:0000734 ! abnormal meiotic spindle intersection_of: PATO:0000574 ! decreased length intersection_of: inheres_in GO:0072687 ! meiotic spindle relationship: inheres_in GO:0072687 ! meiotic spindle created_by: midori creation_date: 2012-01-11T11:30:48Z [Term] id: FYPO:0000736 name: long meiotic spindle def: "A spindle phenotype in which the meiotic spindle is longer than normal." [PomBase:mah] synonym: "elongated meiotic spindle" EXACT [PomBase:mah] synonym: "increased meiotic spindle length" EXACT [PomBase:mah] synonym: "long meiotic spindles" EXACT [PomBase:mah] is_a: FYPO:0000730 ! long spindle is_a: FYPO:0000734 ! abnormal meiotic spindle intersection_of: PATO:0000573 ! increased length intersection_of: inheres_in GO:0072687 ! meiotic spindle relationship: inheres_in GO:0072687 ! meiotic spindle created_by: midori creation_date: 2012-01-11T11:30:48Z [Term] id: FYPO:0000737 name: abnormal meiotic spindle assembly def: "A cellular process phenotype in which assembly of the meiotic spindle is abnormal." [PomBase:mah] synonym: "abnormal spindle assembly involved in meiosis" EXACT [PomBase:mah] is_a: FYPO:0000051 ! abnormal meiosis is_a: FYPO:0000119 ! abnormal spindle assembly intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0090306 ! spindle assembly involved in meiosis intersection_of: qualifier PATO:0000460 ! abnormal relationship: has_output FYPO:0000734 ! abnormal meiotic spindle relationship: inheres_in_part_of GO:0090306 ! spindle assembly involved in meiosis relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-01-11T11:42:55Z [Term] id: FYPO:0000739 name: cellular pigment accumulation phenotype def: "A cellular process phenotype that affects the occurrence of pigment accumulation in a cell." [PomBase:mah] comment: Note that this term refers to GO:0033059 'cellular pigmentation', rather than GO:0043482 'cellular pigment accumulation', because GO:0043482 has paths to 'response to stimulus' in GO. synonym: "cellular pigment accumulation phenotype during mitotic cell cycle" RELATED [PomBase:mah] synonym: "cellular pigment accumulation phenotype during vegetative growth" EXACT [PomBase:mah] synonym: "fission yeast cellular pigment accumulation phenotype" EXACT [PomBase:mah] is_a: FYPO:0001331 ! cellular process phenotype during vegetative growth intersection_of: FYPO:0000001 ! phenotype intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0033059 ! cellular pigmentation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0033059 ! cellular pigmentation created_by: midori creation_date: 2012-01-11T12:21:14Z [Term] id: FYPO:0000740 name: normal cellular pigment accumulation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of cellular pigment accumulation is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: Note that normal cells do not accumulate detectable levels of any pigment; also note that this term refers to GO:0033059 'cellular pigmentation', rather than GO:0043482 'cellular pigment accumulation', because GO:0043482 has paths to 'response to stimulus' in GO. synonym: "normal cellular pigment accumulation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular pigment accumulation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000739 ! cellular pigment accumulation phenotype is_a: FYPO:0001319 ! normal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0033059 ! cellular pigmentation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0033059 ! cellular pigmentation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-01-11T12:27:26Z [Term] id: FYPO:0000741 name: increased cellular pigment accumulation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of cellular pigment accumulation is increased." [PomBase:mah] comment: Note that normal cells do not accumulate detectable levels of any pigment; for this reason, FYPO does not include separate terms for 'increased' and 'abnormal' pigment accumulation. Also note that pigment accumulates in the vacuole. This term refers to GO:0033059 'cellular pigmentation', rather than GO:0043482 'cellular pigment accumulation', because GO:0043482 has paths to 'response to stimulus' in GO. synonym: "abnormal cellular pigment accumulation" EXACT [PomBase:mah] synonym: "altered colony color" RELATED [PomBase:al, PomBase:mah] synonym: "altered colony colour" RELATED [PomBase:al, PomBase:mah] synonym: "increased cellular pigment accumulation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular pigment accumulation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000739 ! cellular pigment accumulation phenotype is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0033059 ! cellular pigmentation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0033059 ! cellular pigmentation created_by: midori creation_date: 2012-01-11T12:29:34Z [Term] id: FYPO:0000742 name: abnormal protein localization to actin cortical patch def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to actin cortical patches is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found in actin cortical patches and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to actin cortical patch" EXACT [PomBase:mah] synonym: "abnormal protein localization to actin cortical patch during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein localization to actin cortical patch during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000928 ! abnormal protein localization to cell cortex intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0044379 ! protein localization to actin cortical patch intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0044379 ! protein localization to actin cortical patch relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-01-11T12:45:30Z [Term] id: FYPO:0000743 name: abnormal actin cortical patch internalization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which actin cortical patch internalization is abnormal. Actin cortical patch internalization is the process in which the patch moves from the cell surface to the inside of the cell." [GO:0044397, PMID:21620704, PomBase:mah] synonym: "abnormal actin cortical patch internalisation" EXACT [PomBase:mah] synonym: "abnormal actin cortical patch internalization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal actin cortical patch internalization during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal actin patch internalization" EXACT [PomBase:vw] is_a: FYPO:0000190 ! abnormal actin cortical patch localization is_a: FYPO:0000790 ! abnormal actin cortical patch organization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0044397 ! actin cortical patch internalization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0044397 ! actin cortical patch internalization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-01-11T12:50:31Z [Term] id: FYPO:0000744 name: normal protein localization to actin cortical patch def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to actin cortical patches is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to actin cortical patch" EXACT [PomBase:mah] synonym: "normal protein localization to actin cortical patch during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to actin cortical patch during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001402 ! normal protein localization to cell cortex is_a: FYPO:0003441 ! normal protein localization to actin cytoskeleton intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0044379 ! protein localization to actin cortical patch intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0044379 ! protein localization to actin cortical patch relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-01-11T01:47:11Z [Term] id: FYPO:0000745 name: delayed actin cortical patch internalization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which actin cortical patch internalization begins later than normal. Actin cortical patch internalization is the process in which the patch moves from the cell surface to the inside of the cell." [GO:0044397, PMID:21620704, PomBase:mah] synonym: "delayed abnormal actin cortical patch internalization during vegetative growth" EXACT [PomBase:mah] synonym: "delayed actin cortical patch internalisation" EXACT [PomBase:mah] synonym: "delayed actin cortical patch internalization during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000743 ! abnormal actin cortical patch internalization is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0044397 ! actin cortical patch internalization relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0044397 ! actin cortical patch internalization created_by: midori creation_date: 2012-01-11T01:57:25Z [Term] id: FYPO:0000746 name: abolished actin cortical patch internalization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which actin cortical patch internalization does not occur. Actin cortical patch internalization is the process in which the patch moves from the cell surface to the inside of the cell." [GO:0044397, PMID:21620704, PomBase:mah] synonym: "abolished actin cortical patch internalisation" EXACT [PomBase:mah] synonym: "abolished actin cortical patch internalization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished actin cortical patch internalization during vegetative growth" EXACT [PomBase:mah] synonym: "actin cortical patch internalization abolished" EXACT [PomBase:mah] is_a: FYPO:0000743 ! abnormal actin cortical patch internalization is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0044397 ! actin cortical patch internalization relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0044397 ! actin cortical patch internalization created_by: midori creation_date: 2012-01-11T01:57:40Z [Term] id: FYPO:0000747 name: growth auxotrophic for adenine def: "Auxotrophy in which a cell is unable to synthesize adenine, and therefore requires adenine in the medium for vegetative cell growth." [PomBase:mah] synonym: "adenine auxotrophy" EXACT [PomBase:mah] synonym: "growth auxotrophic for adenine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "growth auxotrophic for adenine during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000128 ! auxotrophy is_a: PATO:0000422 ! auxotrophic intersection_of: PATO:0000422 ! auxotrophic intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:16708 ! adenine relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:16708 ! adenine created_by: midori creation_date: 2012-01-11T01:59:50Z [Term] id: FYPO:0000748 name: sensitive to mercury def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to mercury ions. Cells stop growing (and may die) at a concentration of mercury ions that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to mercury" EXACT [PomBase:mah] synonym: "sensitive to mercury during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to mercury during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to mercury ions" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:25197 ! mercury cation relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:25197 ! mercury cation created_by: midori creation_date: 2012-01-11T02:03:34Z [Term] id: FYPO:0000749 name: sensitive to selenite ion def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to selenite ((SeO3)2-) ions. Cells stop growing (and may die) at a concentration of selenite ions that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to selenite ion" EXACT [PomBase:mah] synonym: "sensitive to selenite ion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to selenite ion during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to selenite ions" EXACT [PomBase:mah] synonym: "sensitive to selenium" RELATED [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:18212 ! selenite(2-) relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:18212 ! selenite(2-) created_by: midori creation_date: 2012-01-11T02:09:20Z [Term] id: FYPO:0000750 name: sensitive to silver def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to silver ions. Cells stop growing (and may die) at a concentration of silver ions that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to silver" EXACT [PomBase:mah] synonym: "sensitive to silver during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to silver during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to silver ions" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:60253 ! silver cation relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:60253 ! silver cation created_by: midori creation_date: 2012-01-11T02:23:17Z [Term] id: FYPO:0000751 name: sensitive to nickel def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to nickel ions. Cells stop growing (and may die) at a concentration of nickel ions that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to nickel" EXACT [PomBase:mah] synonym: "sensitive to nickel during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to nickel during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to nickel ions" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:25516 ! nickel cation relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:25516 ! nickel cation created_by: midori creation_date: 2012-01-11T02:23:37Z [Term] id: FYPO:0000752 name: resistance to selenate def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of selenate ions than normal." [PomBase:mah] synonym: "resistance to selenate during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to selenate during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to selenate" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:15075 ! selenate relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:15075 ! selenate created_by: midori creation_date: 2012-01-11T02:24:43Z [Term] id: FYPO:0000753 name: normal glutathione gamma-glutamylcysteinyltransferase activity def: "A molecular function phenotype in which the observed rate of glutathione gamma-glutamylcysteinyltransferase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0016756 ! glutathione gamma-glutamylcysteinyltransferase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0016756 ! glutathione gamma-glutamylcysteinyltransferase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-01-11T02:33:09Z [Term] id: FYPO:0000754 name: abnormal glutathione gamma-glutamylcysteinyltransferase activity def: "A molecular function phenotype in which the observed rate of glutathione gamma-glutamylcysteinyltransferase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0016756 ! glutathione gamma-glutamylcysteinyltransferase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0016756 ! glutathione gamma-glutamylcysteinyltransferase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-01-11T02:34:18Z [Term] id: FYPO:0000755 name: decreased glutathione gamma-glutamylcysteinyltransferase activity def: "A molecular function phenotype in which the observed rate of glutathione gamma-glutamylcysteinyltransferase activity is decreased." [PomBase:mah] synonym: "reduced glutathione gamma-glutamylcysteinyltransferase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0000754 ! abnormal glutathione gamma-glutamylcysteinyltransferase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0016756 ! glutathione gamma-glutamylcysteinyltransferase activity relationship: inheres_in GO:0016756 ! glutathione gamma-glutamylcysteinyltransferase activity created_by: midori creation_date: 2012-01-11T02:34:31Z [Term] id: FYPO:0000756 name: sensitive to bafilomycin A1 def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to bafilomycin A1. Cells stop growing (and may die) at a concentration of bafilomycin A1 that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to bafilomycin A1" EXACT [PomBase:mah] synonym: "sensitive to bafilomycin A" RELATED [PomBase:mah] synonym: "sensitive to bafilomycin A1 during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to bafilomycin A1 during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:22689 ! bafilomycin A1 relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:22689 ! bafilomycin A1 created_by: midori creation_date: 2012-01-12T11:24:11Z [Term] id: FYPO:0000757 name: sensitive to nigericin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to nigericin. Cells stop growing (and may die) at a concentration of nigericin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to nigericin" EXACT [PomBase:mah] synonym: "sensitive to nigericin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to nigericin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:7569 ! nigericin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:7569 ! nigericin created_by: midori creation_date: 2012-01-12T11:25:08Z [Term] id: FYPO:0000758 name: sensitive to bismuth def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to bismuth ions. Cells stop growing (and may die) at a concentration of bismuth that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to bismuth" EXACT [PomBase:mah] synonym: "sensitive to bismuth during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to bismuth during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to bismuth ions" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:85543 relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:85543 created_by: midori creation_date: 2012-01-18T03:00:13Z [Term] id: FYPO:0000759 name: sensitive to lead def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to lead ions. Cells stop growing (and may die) at a concentration of lead ions that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to lead" EXACT [PomBase:mah] synonym: "sensitive to lead during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to lead during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to lead ions" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:60252 ! lead cation relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:60252 ! lead cation created_by: midori creation_date: 2012-01-18T03:00:32Z [Term] id: FYPO:0000760 name: normal conjugation def: "A cellular process phenotype in which conjugation is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal conjugation with cellular fusion" EXACT [PomBase:mah] synonym: "normal zygote formation" RELATED [PomBase:mah] is_a: FYPO:0000257 ! normal phenotype is_a: FYPO:0000301 ! mating phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0000747 ! conjugation with cellular fusion intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0000747 ! conjugation with cellular fusion relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-01-18T03:02:59Z [Term] id: FYPO:0000761 name: increased conjugation frequency def: "A conjugation phenotype in which conjugation occurs more frequently than normal." [PomBase:mah] comment: Note that this term refers specifically to conjugation, whereas experiments that measure mating efficiency often do so by counting zygotes plus asci, sometimes also including spores. For such experiments, we recommend using 'increased mating efficiency' (FYPO:0001043). synonym: "increased conjugation efficiency" EXACT [PomBase:mah] synonym: "increased occurrence of conjugation" EXACT [PomBase:mah] synonym: "increased zygote formation" RELATED [PomBase:mah] is_a: FYPO:0000003 ! cell population phenotype created_by: midori creation_date: 2012-01-18T03:03:19Z [Term] id: FYPO:0000763 name: resistance to cadmium def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of cadmium ions than normal." [PomBase:mah] synonym: "resistance to cadmium during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to cadmium during vegetative growth" EXACT [PomBase:mah] synonym: "resistance to cadmium ion" EXACT [PomBase:mah] synonym: "resistant to cadmium" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:22978 ! cadmium molecular entity relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:22978 ! cadmium molecular entity created_by: midori creation_date: 2012-02-09T03:40:24Z [Term] id: FYPO:0000764 name: resistance to cycloheximide def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of selenate ions than normal." [PomBase:mah] synonym: "resistance to cycloheximide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to cycloheximide during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to cycloheximide" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:27641 ! cycloheximide relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:27641 ! cycloheximide created_by: midori creation_date: 2012-02-09T03:40:24Z [Term] id: FYPO:0000765 name: resistance to leptomycin B def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of leptomycin B than normal." [PomBase:mah] synonym: "resistance to leptomycin B during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to leptomycin B during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to leptomycin B" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:52646 ! leptomycin B relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:52646 ! leptomycin B created_by: midori creation_date: 2012-02-09T03:40:24Z [Term] id: FYPO:0000766 name: resistance to N-ethylmaleimide def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of selenate ions than normal." [PomBase:mah] synonym: "resistance to N-ethylmaleimide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to N-ethylmaleimide during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to N-ethylmaleimide" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:44485 ! N-ethylmaleimide relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:44485 ! N-ethylmaleimide created_by: midori creation_date: 2012-02-09T03:40:24Z [Term] id: FYPO:0000767 name: resistance to staurosporine def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of selenate ions than normal." [PomBase:mah] synonym: "resistance to staurosporine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to staurosporine during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to staurosporine" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:15738 ! staurosporine relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:15738 ! staurosporine created_by: midori creation_date: 2012-02-09T03:40:24Z [Term] id: FYPO:0000768 name: resistance to valinomycin def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of selenate ions than normal." [PomBase:mah] synonym: "resistance to valinomycin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to valinomycin during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to valinomycin" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:28545 ! valinomycin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:28545 ! valinomycin created_by: midori creation_date: 2012-02-09T03:40:24Z [Term] id: FYPO:0000769 name: abnormal nuclear envelope morphology during vegetative growth def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of all or part of the nuclear envelope is abnormal." [PomBase:mah] comment: Note that an abnormal nuclear envelope organization process may, but does not necessarily, result in abnormal nuclear envelope morphology. synonym: "abnormal nuclear envelope morphology during mitotic cell cycle" EXACT [PomBase:mah] synonym: "abnormal nuclear membrane morphology" NARROW [PomBase:mah] is_a: FYPO:0000062 ! abnormal nuclear morphology during vegetative growth is_a: FYPO:0000353 ! abnormal endomembrane system morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005635 ! nuclear envelope intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005635 ! nuclear envelope relationship: output_of FYPO:0000815 ! abnormal nuclear envelope organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-02-09T03:51:02Z [Term] id: FYPO:0000770 name: branched nuclear inner membrane def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the nuclear inner membrane forms branched structures that extend into the nuclear lumen." [PMID:21880100, PomBase:mah] synonym: "branched nuclear inner membrane during mitotic cell cycle" RELATED [PomBase:mah] synonym: "branched nuclear inner membrane during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000769 ! abnormal nuclear envelope morphology during vegetative growth is_a: PATO:0000402 ! branched intersection_of: PATO:0000402 ! branched intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005637 ! nuclear inner membrane relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005637 ! nuclear inner membrane created_by: midori creation_date: 2012-02-09T03:54:48Z [Term] id: FYPO:0000771 name: normal nuclear pore distribution def: "A localization phenotype observed in the vegetative growth phase of the life cycle in which the spatial arrangement of nuclear pores within the nuclear envelope is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal nuclear pore distribution during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal nuclear pore distribution during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000644 ! normal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0031081 ! nuclear pore distribution intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0031081 ! nuclear pore distribution relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-02-09T04:03:08Z [Term] id: FYPO:0000772 name: perforated nuclear envelope def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which perforations or gaps (other than nuclear pores) are present in the nuclear envelope." [PomBase:mah] synonym: "disrupted nuclear envelope" RELATED [PomBase:mah] synonym: "disrupted nuclear membrane" RELATED [PomBase:mah] synonym: "gapped nuclear envelope" EXACT [PomBase:mah] synonym: "perforated nuclear envelope during mitotic cell cycle" RELATED [PomBase:mah] synonym: "perforated nuclear envelope during vegetative growth" EXACT [PomBase:mah] synonym: "perforated nuclear membrane" RELATED [PomBase:mah] is_a: FYPO:0000769 ! abnormal nuclear envelope morphology during vegetative growth is_a: PATO:0002112 ! perforate intersection_of: PATO:0002112 ! perforate intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005635 ! nuclear envelope relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005635 ! nuclear envelope created_by: midori creation_date: 2012-02-09T04:12:08Z [Term] id: FYPO:0000773 name: abnormal pre-replicative complex assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which pre-replicative complex assembly is abnormal." [PomBase:mah] synonym: "abnormal pre-RC assembly" EXACT [PomBase:mah] synonym: "abnormal pre-replicative complex assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal pre-replicative complex assembly during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal pre-replicative complex formation" EXACT [GO:0006267, PomBase:mah] is_a: FYPO:0000447 ! abnormal protein complex assembly is_a: FYPO:0002734 ! abnormal cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006267 ! pre-replicative complex assembly involved in nuclear cell cycle DNA replication intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006267 ! pre-replicative complex assembly involved in nuclear cell cycle DNA replication relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-02-09T04:18:40Z [Term] id: FYPO:0000774 name: decreased pre-replicative complex assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of pre-replicative complex assembly is decreased." [PomBase:mah] synonym: "decreased pre-RC assembly" EXACT [PomBase:mah] synonym: "decreased pre-replicative complex assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased pre-replicative complex assembly during vegetative growth" EXACT [PomBase:mah] synonym: "decreased pre-replicative complex formation" EXACT [GO:0006267, PomBase:mah] synonym: "reduced pre-replicative complex assembly" EXACT [PomBase:mah] is_a: FYPO:0000773 ! abnormal pre-replicative complex assembly is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006267 ! pre-replicative complex assembly involved in nuclear cell cycle DNA replication relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006267 ! pre-replicative complex assembly involved in nuclear cell cycle DNA replication created_by: midori creation_date: 2012-02-09T04:26:56Z [Term] id: FYPO:0000775 name: abnormal protein phosphorylation during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, is abnormal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein phosphorylation during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000329 ! abnormal protein modification during vegetative growth is_a: FYPO:0002677 ! abnormal protein phosphorylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006468 ! protein phosphorylation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006468 ! protein phosphorylation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-02-09T04:32:41Z [Term] id: FYPO:0000776 name: normal protein phosphorylation during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein phosphorylation during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000549 ! normal protein modification during vegetative growth is_a: FYPO:0004422 ! normal protein phosphorylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-02-09T04:33:28Z [Term] id: FYPO:0000777 name: abnormal double-strand break repair def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which double-strand break repair is abnormal." [PomBase:mah] synonym: "abnormal double-strand break repair during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal double-strand break repair during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal DSB repair" EXACT [PomBase:vw] is_a: FYPO:0000188 ! abnormal DNA repair intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006302 ! double-strand break repair intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006302 ! double-strand break repair relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-02-09T04:35:48Z [Term] id: FYPO:0000778 name: delayed double-strand break repair def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which double-strand break repair begins later than normal." [PomBase:mah] synonym: "delayed double-strand break repair during mitotic cell cycle" RELATED [PomBase:mah] synonym: "delayed double-strand break repair during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000777 ! abnormal double-strand break repair is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006302 ! double-strand break repair relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006302 ! double-strand break repair created_by: midori creation_date: 2012-02-09T04:37:10Z [Term] id: FYPO:0000779 name: inviable elongated vegetative cell with central constriction alt_id: FYPO:0000018 def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is inviable, is longer than normal and has an abnormal shape featuring a constriction at the center of the cell, corresponding to the cell division site. In some such cells, the diameter at the ends is much greater than in wild-type cells." [PomBase:mah, PomBase:vw] comment: Note that cell with this phenotype, often called dumbbell-shaped, are usually also elongated. The distinction between this phenotype and swollen elongated cells (FYPO:0001429) is that dumbbell-shaped cells have a constriction along the long axis, whereas swollen elongated cells do not. Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "cell morphology, elongated dumbbell" RELATED [PomBase:mah] synonym: "cell morphology, long dumbbell" RELATED [PomBase:vw] synonym: "elongated dumbbell morphology" RELATED [PomBase:mah] synonym: "inviable elongated cell with central constriction during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable elongated cell with central constriction during vegetative growth" EXACT [PomBase:mah] synonym: "inviable elongated dumbbell-shaped vegetative cell" RELATED [PomBase:vw] synonym: "inviable elongated swollen vegetative cell with constricted region at cell division site" EXACT [PomBase:vw] is_a: FYPO:0000950 ! elongated aseptate cell is_a: FYPO:0002196 ! abnormal vegetative cell shape created_by: midori creation_date: 2012-02-13T12:48:01Z [Term] id: FYPO:0000780 name: increased transcription during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription occurs to a greater extent than normal. All genes, or a specific subset of genes, may be affected." [PomBase:mah] comment: Use this term if there is evidence, such as labeled nucleotide incorporation, showing that transcription rather than RNA stability is affected; otherwise, use 'increased RNA level' (FYPO:0000825). synonym: "increased transcription during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001335 ! transcription regulation phenotype during vegetative growth is_a: FYPO:0002875 ! increased transcription intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006351 ! transcription, DNA-templated relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_output FYPO:0000825 ! increased RNA level during vegetative growth relationship: inheres_in GO:0006351 ! transcription, DNA-templated created_by: midori creation_date: 2012-02-28T03:56:27Z [Term] id: FYPO:0000781 name: decreased transcription during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription occurs to a lower extent than normal. All genes, or a specific subset of genes, may be affected." [PomBase:mah] comment: Use this term if there is evidence, such as labeled nucleotide incorporation, showing that transcription rather than RNA stability is affected; otherwise, use 'decreased RNA level' (FYPO:0000826). synonym: "decreased transcription during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased transcription during vegetative growth" EXACT [PomBase:mah] synonym: "reduced transcription during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001335 ! transcription regulation phenotype during vegetative growth is_a: FYPO:0002876 ! decreased transcription intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006351 ! transcription, DNA-templated relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_output FYPO:0001117 ! decreased RNA level during vegetative growth relationship: inheres_in GO:0006351 ! transcription, DNA-templated created_by: midori creation_date: 2012-02-28T03:57:44Z [Term] id: FYPO:0000782 name: mislocalized protein during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a protein is observed in a particular location where it is not normally found." [PomBase:mah] comment: The difference between this term and 'abnormal protein localization' (FYPO:0000443) is that 'mislocalized protein' describes a protein that is observed in a place where it is not normally found, whereas 'abnormal protein localization' additionally encompasses the absence of protein from a place where it is normally found. FYPO:0000782 can therefore be used in any case where a protein is in a different location in a mutant compared to wild type, whereas additional information is usually required to support annotation to FYPO:0000443 or its descendants. We recommend noting which protein(s) were used in the assay when annotating to this term. subset: qc_do_not_manually_annotate synonym: "mislocalised protein" EXACT [PomBase:mah] synonym: "mislocalized protein during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0003452 ! mislocalized protein is_a: FYPO:0004639 ! abnormal cellular physical quality phenotype during vegetative growth intersection_of: PATO:0000628 ! mislocalised intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CHEBI:36080 ! protein relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CHEBI:36080 ! protein relationship: output_of FYPO:0000443 ! abnormal protein localization during vegetative growth created_by: midori creation_date: 2012-02-29T12:48:27Z [Term] id: FYPO:0000783 name: protein mislocalized to cytoplasm def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a protein that is not normally found in the cytoplasm is observed there." [PomBase:mah] comment: Note that this term can be used to annotate any case where a protein is found in the cytoplasm in a mutant, but not in wild type. In some cases, there may be enough additional information to annotate to 'abnormal protein localization' (FYPO:0000443) or one of its descendants. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "ectopic protein localization to cytoplasm" EXACT [PomBase:vw] synonym: "protein mislocalised to cytoplasm" EXACT [PomBase:mah] synonym: "protein mislocalized to cytoplasm during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein mislocalized to cytoplasm during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000782 ! mislocalized protein during vegetative growth intersection_of: PATO:0000628 ! mislocalised intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CHEBI:36080 ! protein intersection_of: towards GO:0005737 ! cytoplasm relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CHEBI:36080 ! protein relationship: towards GO:0005737 ! cytoplasm created_by: midori creation_date: 2012-02-29T12:49:47Z [Term] id: FYPO:0000784 name: protein mislocalized to nucleus during vegetative growth alt_id: FYPO:0001251 def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a protein that is not normally found in the nucleus is observed there." [PomBase:mah] comment: Note that this term can be used to annotate any case where a protein is found in the nucleus in a mutant, but not in wild type. In some cases, there may be enough additional information to annotate to 'abnormal protein localization' (FYPO:0000443) or one of its descendants. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "ectopic protein localization to nucleus during vegetative growth" EXACT [PomBase:vw] synonym: "protein mislocalised to nucleus during vegetative growth" EXACT [PomBase:mah] synonym: "protein mislocalized to nucleus during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000782 ! mislocalized protein during vegetative growth is_a: FYPO:0003453 ! protein mislocalized to nucleus intersection_of: PATO:0000628 ! mislocalised intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CHEBI:36080 ! protein intersection_of: towards GO:0005634 ! nucleus relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CHEBI:36080 ! protein relationship: output_of FYPO:0001129 ! abnormal protein localization to nucleus during vegetative growth relationship: towards GO:0005634 ! nucleus created_by: midori creation_date: 2012-02-29T12:50:40Z [Term] id: FYPO:0000785 name: sensitive to formamide def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to formamide. Cells stop growing (and may die) at a concentration of formamide that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to formamide" EXACT [PomBase:mah] synonym: "sensitive to formamide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to formamide during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:16397 ! formamide relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:16397 ! formamide created_by: midori creation_date: 2012-02-29T01:30:18Z [Term] id: FYPO:0000786 name: increased plasmid loss def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which plasmids are lost at a higher frequency than normal. Plasmid loss occurs when one or both daughter cells do not inherit copies of a plasmid from the mother cell, and may result from failure of plasmid replication or segregation." [PomBase:mah] comment: Note that in budding yeast, increased plasmid loss is often called a minichromosome maintenance defect, because "minichromosome" is roughly synonymous with an autonomously replicated and segregated plasmid in that organism. synonym: "increased plasmid loss during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased plasmid loss during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001320 ! vegetative cell phenotype is_a: FYPO:0003037 ! abnormal cell phenotype created_by: midori creation_date: 2012-02-29T01:39:20Z [Term] id: FYPO:0000787 name: abnormal histone H3-K9 trimethylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which trimethylation of lysine at position 9 of histone H3 is abnormal." [PomBase:mah] synonym: "abnormal histone H3 K9 trimethylation" EXACT [GO:0036124, PomBase:mah] synonym: "abnormal histone H3-K9 trimethylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal histone H3-K9 trimethylation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal histone H3K9 trimethylation" EXACT [PomBase:vw] synonym: "abnormal histone H3K9me3" EXACT [PomBase:mah] synonym: "abnormal histone lysine H3 K9 trimethylation" EXACT [GO:0036124, PomBase:mah] is_a: FYPO:0000458 ! abnormal histone H3-K9 methylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0036124 ! histone H3-K9 trimethylation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0036124 ! histone H3-K9 trimethylation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-02-29T01:43:54Z [Term] id: FYPO:0000788 name: abnormal histone H3-K14 acetylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which acetylation of lysine at position 14 of histone H3 is abnormal." [PomBase:mah] synonym: "abnormal histone H3-K14 acetylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal histone H3-K14 acetylation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal histone H3K14 acetylation" EXACT [GO:0044154, PomBase:vw] is_a: FYPO:0002361 ! abnormal histone H3 acetylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0044154 ! histone H3-K14 acetylation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0044154 ! histone H3-K14 acetylation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-02-29T01:46:18Z [Term] id: FYPO:0000789 name: sensitive to 1-NA-PP1 def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to 1-NA-PP1. Cells stop growing (and may die) at a concentration of 1-NA-PP1 that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to 1-NA-PP1" EXACT [PomBase:mah] synonym: "sensitive to 1-NA-PP1 during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to 1-NA-PP1 during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to 1-tert-butyl-3-naphthalen-1-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine " EXACT [CHEBI:52310, PomBase:mah] synonym: "sensitive to 4-amino-1-tert-butyl-3-(1'-naphthyl)pyrazolo[3,4-d]pyrimidine " EXACT [CHEBI:52310, PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:52310 ! 1-NA-PP1 relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:52310 ! 1-NA-PP1 created_by: midori creation_date: 2012-02-29T01:53:55Z [Term] id: FYPO:0000790 name: abnormal actin cortical patch organization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which actin cortical patch organization is abnormal. The process normally results in the assembly, arrangement of constituent parts, or disassembly of an actin cortical patch." [GO:0044396, PomBase:mah] synonym: "abnormal actin cortical patch organisation" EXACT [PomBase:mah] synonym: "abnormal actin cortical patch organization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal actin cortical patch organization during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000801 ! abnormal actin cytoskeleton organization during vegetative growth is_a: FYPO:0001354 ! abnormal cellular component assembly during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0044396 ! actin cortical patch organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0044396 ! actin cortical patch organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-02-29T03:11:58Z [Term] id: FYPO:0000791 name: abnormal actin cortical patch morphology def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of actin cortical patches is abnormal." [PomBase:mah] synonym: "abnormal actin cortical patch morphology during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal actin cortical patch morphology during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000350 ! abnormal actin cytoskeleton morphology during vegetative growth is_a: FYPO:0003987 ! abnormal actin cortical patch intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0030479 ! actin cortical patch intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0030479 ! actin cortical patch relationship: output_of FYPO:0000790 ! abnormal actin cortical patch organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-02-29T03:14:15Z [Term] id: FYPO:0000792 name: normal glycerol dehydrogenase activity def: "A molecular function phenotype in which the observed rate of glycerol dehydrogenase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0008888 ! glycerol dehydrogenase [NAD+] activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0008888 ! glycerol dehydrogenase [NAD+] activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-02-29T03:25:55Z [Term] id: FYPO:0000793 name: abnormal glycerol dehydrogenase activity def: "A molecular function phenotype in which the observed rate of glycerol dehydrogenase activity is abnormal." [PomBase:mah] is_a: FYPO:0000689 ! abnormal oxidoreductase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0008888 ! glycerol dehydrogenase [NAD+] activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0008888 ! glycerol dehydrogenase [NAD+] activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-02-29T03:26:33Z [Term] id: FYPO:0000794 name: abolished glycerol dehydrogenase activity def: "A molecular function phenotype in which glycerol dehydrogenase activity is absent." [PomBase:mah] synonym: "glycerol dehydrogenase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0000793 ! abnormal glycerol dehydrogenase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0008888 ! glycerol dehydrogenase [NAD+] activity relationship: towards GO:0008888 ! glycerol dehydrogenase [NAD+] activity created_by: midori creation_date: 2012-02-29T03:27:45Z [Term] id: FYPO:0000795 name: decreased glycerol dehydrogenase activity def: "A molecular function phenotype in which the observed rate of glycerol dehydrogenase activity is decreased." [PomBase:mah] synonym: "reduced glycerol dehydrogenase activity" EXACT [PomBase:mah] is_a: FYPO:0000690 ! decreased oxidoreductase activity is_a: FYPO:0000793 ! abnormal glycerol dehydrogenase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0008888 ! glycerol dehydrogenase [NAD+] activity relationship: inheres_in GO:0008888 ! glycerol dehydrogenase [NAD+] activity created_by: midori creation_date: 2012-02-29T03:27:51Z [Term] id: FYPO:0000796 name: increased glycerol dehydrogenase activity def: "A molecular function phenotype in which the observed rate of glycerol dehydrogenase activity is increased." [PomBase:mah] synonym: "increased peptidase activity" EXACT [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0000793 ! abnormal glycerol dehydrogenase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0008888 ! glycerol dehydrogenase [NAD+] activity relationship: inheres_in GO:0008888 ! glycerol dehydrogenase [NAD+] activity created_by: midori creation_date: 2012-02-29T03:27:58Z [Term] id: FYPO:0000797 name: sensitive to tert-butyl hydroperoxide def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to tert-butyl hydroperoxide (TBHP or t-BOOH). Cells stop growing (and may die) at a concentration of tert-butyl hydroperoxide that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to tert-butyl hydroperoxide" EXACT [PomBase:mah] synonym: "sensitive to 2-methyl-prop-2-yl-hydroperoxide" EXACT [CHEBI:64090] synonym: "sensitive to t-BOOH" EXACT [PomBase:al, PomBase:mah] synonym: "sensitive to TBHP" EXACT [CHEBI:64090, PomBase:al] synonym: "sensitive to tert-butyl hydroperoxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to tert-butyl hydroperoxide during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:64090 ! tert-butyl hydroperoxide relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:64090 ! tert-butyl hydroperoxide created_by: midori creation_date: 2012-02-29T03:49:47Z [Term] id: FYPO:0000798 name: sensitive to anisomycin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to anisomycin. Cells stop growing (and may die) at a concentration of anisomycin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to anisomycin" EXACT [PomBase:mah] synonym: "sensitive to anisomycin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to anisomycin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:338412 ! (-)-anisomycin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:338412 ! (-)-anisomycin created_by: midori creation_date: 2012-02-29T03:54:43Z [Term] id: FYPO:0000799 name: sensitive to diamide def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide, also known as diamide. Cells stop growing (and may die) at a concentration of diamide that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to diamide" EXACT [PomBase:mah] synonym: "sensitive to diamide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to diamide during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide" EXACT [CHEBI:48958] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:48958 ! 1,1'-azobis(N,N-dimethylformamide) relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:48958 ! 1,1'-azobis(N,N-dimethylformamide) created_by: midori creation_date: 2012-03-01T01:37:57Z [Term] id: FYPO:0000800 name: increased concentration of substance in growth medium def: "A phenotype in which the concentration of a substance released into the growth medium by cells is higher than normal." [PomBase:mah] comment: Note that this term refers only to substances released into the growth medium by cells, not to the concentration of ingredients in the medium as formulated. Consider also annotating to 'increased level of substance in cell' (FYPO:0000990), if there is evidence that the intracellular level of a substance is also increased. synonym: "increased accumulation of substance in growth medium" RELATED [PomBase:mah] synonym: "increased level of substance in growth medium" EXACT [PomBase:mah] synonym: "increased release of substance into growth medium" RELATED [PomBase:mah] is_a: FYPO:0001155 ! altered effect on growth medium is_a: PATO:0001162 ! increased concentration intersection_of: PATO:0001162 ! increased concentration intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: towards CHEBI:24431 ! chemical entity relationship: inheres_in BTO:0000316 ! culture medium relationship: towards CHEBI:24431 ! chemical entity created_by: midori creation_date: 2012-03-07T03:41:12Z [Term] id: FYPO:0000801 name: abnormal actin cytoskeleton organization during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which actin cytoskeleton organization is abnormal." [GO:0030036, PMID:19713940, PomBase:mah] comment: Consider annotating to 'abnormal actin cytoskeleton' (FYPO:0002398), but note that an abnormal actin cytoskeleton organization process may, but does not necessarily, result in a physically abnormal actin cytoskeleton. synonym: "abnormal actin cytoskeleton organisation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal actin cytoskeleton organization during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001328 ! abnormal cytoskeleton organization during vegetative growth is_a: FYPO:0004803 ! abnormal actin cytoskeleton organization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0030036 ! actin cytoskeleton organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0030036 ! actin cytoskeleton organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-01T02:05:28Z [Term] id: FYPO:0000802 name: abnormal cytoskeleton organization def: "A cellular process phenotype in which cytoskeleton organization is abnormal." [GO:0007010, PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. Note that an abnormal cytoskeleton organization process may, but does not necessarily, result in a physically abnormal cytoskeleton. subset: qc_do_not_manually_annotate synonym: "abnormal cytoskeleton organisation" EXACT [PomBase:mah] is_a: FYPO:0000295 ! cytoskeleton organization phenotype is_a: FYPO:0000335 ! abnormal cellular component organization intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0007010 ! cytoskeleton organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0007010 ! cytoskeleton organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-01T02:43:53Z [Term] id: FYPO:0000803 name: increased concentration of DHA in growth medium def: "A phenotype in which the concentration of glycerone (also called 1,3-dihydroxypropan-2-one, dihydroxyacetone, or DHA) released into the growth medium by cells is higher than normal." [PomBase:mah] synonym: "increased accumulation of DHA in growth medium" RELATED [PomBase:mah] synonym: "increased concentration of 1,3-dihydroxypropan-2-one in growth medium" EXACT [CHEBI:16016] synonym: "increased concentration of dihydroxyacetone in growth medium" EXACT [CHEBI:16016] synonym: "increased concentration of glycerone in growth medium" EXACT [CHEBI:16016] synonym: "increased level of DHA in growth medium" EXACT [PomBase:mah] synonym: "increased release of DHA into growth medium" RELATED [PomBase:mah] is_a: FYPO:0000800 ! increased concentration of substance in growth medium intersection_of: PATO:0001162 ! increased concentration intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: towards CHEBI:16016 ! glycerone relationship: inheres_in BTO:0000316 ! culture medium relationship: towards CHEBI:16016 ! glycerone created_by: midori creation_date: 2012-03-07T03:42:46Z [Term] id: FYPO:0000804 name: abnormal endomembrane system organization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which endomembrane system organization is abnormal. Endomembrane system organization results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system, which encompasses the endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope." [GO:0010256, GO:0012505, PomBase:mah] comment: Consider annotating to 'abnormal endomembrane system morphology' (FYPO:0000353), but note that an abnormal endomembrane system organization process may, but does not necessarily, result in abnormal endomembrane system morphology. synonym: "abnormal endomembrane system organisation" EXACT [PomBase:mah] synonym: "abnormal endomembrane system organization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal endomembrane system organization during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001353 ! abnormal cellular component organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0010256 ! endomembrane system organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0010256 ! endomembrane system organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-01T03:25:09Z [Term] id: FYPO:0000805 name: abnormal endoplasmic reticulum organization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which endoplasmic reticulum (ER) organization is abnormal. ER organization results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GO:0007029, PomBase:mah] comment: Consider annotating to 'abnormal endoplasmic reticulum morphology' (FYPO:0000354), but note that an abnormal endoplasmic reticulum organization process may, but does not necessarily, result in abnormal endoplasmic reticulum morphology. synonym: "abnormal endoplasmic reticulum organisation" EXACT [PomBase:mah] synonym: "abnormal endoplasmic reticulum organization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal endoplasmic reticulum organization during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal ER organization" EXACT [PomBase:mah] is_a: FYPO:0001353 ! abnormal cellular component organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0007029 ! endoplasmic reticulum organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0007029 ! endoplasmic reticulum organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-01T03:25:48Z [Term] id: FYPO:0000806 name: abnormal Golgi organization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which Golgi organization is abnormal. Golgi organization results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GO:0007030, PomBase:mah] comment: Consider annotating to 'abnormal Golgi morphology' (FYPO:0000349), but note that an abnormal Golgi organization process may, but does not necessarily, result in abnormal Golgi morphology. synonym: "abnormal Golgi organisation" EXACT [PomBase:mah] synonym: "abnormal Golgi organization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal Golgi organization during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001353 ! abnormal cellular component organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0007030 ! Golgi organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0007030 ! Golgi organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-01T03:29:07Z [Term] id: FYPO:0000807 name: abnormal kinetochore organization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which kinetochore organization is abnormal. Kinetochore organization results in the assembly, arrangement of constituent parts, or disassembly of the kinetochore, the chromosomal attachment point for the spindle microtubules." [GO:0051383, PomBase:mah] comment: Consider annotating to 'abnormal kinetochore structure' (FYPO:0000050), but note that an abnormal kinetochore organization process may, but does not necessarily, result in abnormal kinetochore structure. synonym: "abnormal kinetochore organisation" EXACT [PomBase:mah] synonym: "abnormal kinetochore organization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal kinetochore organization during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000641 ! abnormal chromosome organization is_a: FYPO:0001353 ! abnormal cellular component organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0051383 ! kinetochore organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0051383 ! kinetochore organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-01T03:29:58Z [Term] id: FYPO:0000808 name: abnormal lipid particle organization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which lipid particle organization is abnormal. Lipid particle organization results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle." [GO:0034389, PomBase:mah] comment: Consider annotating to 'abnormal lipid particle morphology' (FYPO:0000356), but note that an abnormal lipid particle organization process may, but does not necessarily, result in abnormal lipid particle morphology. synonym: "abnormal lipid droplet organization" EXACT [GO:0005811] synonym: "abnormal lipid particle organisation" EXACT [PomBase:mah] synonym: "abnormal lipid particle organization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal lipid particle organization during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001353 ! abnormal cellular component organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0034389 ! lipid particle organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0034389 ! lipid particle organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-01T03:31:02Z [Term] id: FYPO:0000809 name: abnormal mitochondrion organization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitochondrion organization is abnormal. Mitochondrion organization results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion, and includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome, as well as synthesis of new mitochondrial components." [GO:0007005, PomBase:mah] comment: Consider annotating to 'abnormal mitochondrial morphology' (FYPO:0000359), but note that an abnormal mitochondrion organization process may, but does not necessarily, result in abnormal mitochondrial morphology. synonym: "abnormal mitochondrion organisation" EXACT [PomBase:mah] synonym: "abnormal mitochondrion organization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal mitochondrion organization during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001353 ! abnormal cellular component organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0007005 ! mitochondrion organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0007005 ! mitochondrion organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-01T03:31:48Z [Term] id: FYPO:0000810 name: abnormal nucleus organization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which nucleus organization is abnormal. Nucleus organization results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GO:0006997, PomBase:mah] comment: Consider annotating to 'abnormal nuclear morphology' (FYPO:0000062), but note that an abnormal nucleus organization process may, but does not necessarily, result in abnormal nuclear morphology. synonym: "abnormal nuclear organization" EXACT [PomBase:mah] synonym: "abnormal nucleus organisation" EXACT [PomBase:mah] synonym: "abnormal nucleus organization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal nucleus organization during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001353 ! abnormal cellular component organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006997 ! nucleus organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006997 ! nucleus organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-01T03:34:22Z [Term] id: FYPO:0000811 name: abnormal peroxisome organization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which peroxisome organization is abnormal. Peroxisome organization results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome." [GO:0007031, PomBase:mah] comment: Consider annotating to 'abnormal peroxisomal morphology' (FYPO:0000362), but note that an abnormal peroxisome organization process may, but does not necessarily, result in abnormal peroxisome morphology. synonym: "abnormal peroxisome organisation" EXACT [PomBase:mah] synonym: "abnormal peroxisome organization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal peroxisome organization during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001353 ! abnormal cellular component organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0007031 ! peroxisome organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0007031 ! peroxisome organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-01T03:38:04Z [Term] id: FYPO:0000812 name: abnormal vacuole organization during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which vacuole organization is abnormal. Vacuole organization results in the assembly, arrangement of constituent parts, or disassembly of a vacuole." [GO:0007033, PomBase:mah] comment: Consider annotating to 'abnormal vacuolar morphology during vegetative growth' (FYPO:0000368), but note that an abnormal vacuole organization process may, but does not necessarily, result in abnormal vacuolar morphology. synonym: "abnormal vacuolar organisation during vegetative growth" EXACT [PomBase:vw] synonym: "abnormal vacuolar organization during vegetative growth" EXACT [PomBase:vw] synonym: "abnormal vacuole organisation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal vacuole organization during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001353 ! abnormal cellular component organization during vegetative growth is_a: FYPO:0002803 ! abnormal vacuole organization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0007033 ! vacuole organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0007033 ! vacuole organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-01T03:38:52Z [Term] id: FYPO:0000813 name: abnormal plasma membrane organization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which plasma membrane organization is abnormal. Plasma membrane organization results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GO:0007009, PomBase:mah] comment: Consider annotating to 'abnormal plasma membrane morphology' (FYPO:0000364), but note that an abnormal plasma membrane organization process may, but does not necessarily, result in abnormal plasma membrane morphology. synonym: "abnormal plasma membrane organisation" EXACT [PomBase:mah] synonym: "abnormal plasma membrane organization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal plasma membrane organization during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001351 ! abnormal membrane organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0007009 ! plasma membrane organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0007009 ! plasma membrane organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-01T03:41:39Z [Term] id: FYPO:0000814 name: abnormal nucleolus organization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which nucleolus organization is abnormal. Nucleolus organization results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus." [PomBase:mah] comment: Consider annotating to 'abnormal nucleolar morphology' (FYPO:0000361), but note that an abnormal nucleolus organization process may, but does not necessarily, result in abnormal nucleolar morphology. synonym: "abnormal nucleolus organisation" EXACT [PomBase:mah] synonym: "abnormal nucleolus organization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal nucleolus organization during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000810 ! abnormal nucleus organization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0007000 ! nucleolus organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0007000 ! nucleolus organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-01T03:42:44Z [Term] id: FYPO:0000815 name: abnormal nuclear envelope organization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which nuclear envelope organization is abnormal. Nuclear envelope organization results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope." [PomBase:mah] comment: Consider annotating to 'abnormal nuclear envelope morphology' (FYPO:0000769), but note that an abnormal nuclear envelope organization process may, but does not necessarily, result in abnormal nuclear envelope morphology. synonym: "abnormal nuclear envelope organisation" EXACT [PomBase:mah] synonym: "abnormal nuclear envelope organization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal nuclear envelope organization during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000810 ! abnormal nucleus organization is_a: FYPO:0001351 ! abnormal membrane organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006998 ! nuclear envelope organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006998 ! nuclear envelope organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-01T03:45:03Z [Term] id: FYPO:0000816 name: decreased concentration of substance in growth medium def: "A phenotype in which the concentration of a substance released into the growth medium by cells is lower than normal." [PomBase:mah] comment: Note that this term refers only to substances released into the growth medium by cells, not to the concentration of ingredients in the medium as formulated. Consider also annotating to 'decreased level of substance in cell' (FYPO:0000991), if there is evidence that the intracellular level of a substance is also increased. synonym: "decreased accumulation of substance in growth medium" RELATED [PomBase:mah] synonym: "decreased level of substance in growth medium" EXACT [PomBase:mah] synonym: "decreased release of substance into growth medium" RELATED [PomBase:mah] synonym: "reduced concentration of substance in growth medium" EXACT [PomBase:mah] is_a: FYPO:0001155 ! altered effect on growth medium is_a: PATO:0001163 ! decreased concentration intersection_of: PATO:0001163 ! decreased concentration intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: towards CHEBI:24431 ! chemical entity relationship: inheres_in BTO:0000316 ! culture medium relationship: towards CHEBI:24431 ! chemical entity created_by: midori creation_date: 2012-03-07T03:47:46Z [Term] id: FYPO:0000817 name: increased concentration of pheromone in growth medium def: "A phenotype in which the concentration of a peptide pheromone released into the growth medium by cells is higher than normal." [PomBase:mah] synonym: "increased accumulation of pheromone in growth medium" RELATED [PomBase:mah] synonym: "increased concentration of peptide pheromone in growth medium" EXACT [PomBase:mah] synonym: "increased level of pheromone in growth medium" EXACT [PomBase:mah] synonym: "increased release of pheromone into growth medium" RELATED [PomBase:mah] synonym: "pheromone production: increased" RELATED [SGD:phenotype_annotation] is_a: FYPO:0000800 ! increased concentration of substance in growth medium intersection_of: PATO:0001162 ! increased concentration intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: towards CHEBI:38579 ! peptide pheromone relationship: inheres_in BTO:0000316 ! culture medium relationship: towards CHEBI:38579 ! peptide pheromone created_by: midori creation_date: 2012-03-07T03:50:03Z [Term] id: FYPO:0000818 name: increased concentration of M-factor in growth medium def: "A phenotype in which the concentration of M-factor, the mating pheromone produced by mating type minus cells, released into the growth medium is higher than normal." [PomBase:mah] synonym: "increased accumulation of M-factor in growth medium" RELATED [PomBase:mah] synonym: "increased level of M-factor in growth medium" EXACT [PomBase:mah] synonym: "increased release of M-factor into growth medium" RELATED [PomBase:mah] is_a: FYPO:0000817 ! increased concentration of pheromone in growth medium intersection_of: PATO:0001162 ! increased concentration intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: towards CHEBI:64120 ! M-factor relationship: inheres_in BTO:0000316 ! culture medium relationship: towards CHEBI:64120 ! M-factor created_by: midori creation_date: 2012-03-07T04:12:02Z [Term] id: FYPO:0000819 name: increased concentration of P-factor in growth medium def: "A phenotype in which the concentration of P-factor, the mating pheromone produced by mating type plus cells, released into the growth medium is higher than normal." [PomBase:mah] synonym: "increased accumulation of P-factor in growth medium" RELATED [PomBase:mah] synonym: "increased level of P-factor in growth medium" EXACT [PomBase:mah] synonym: "increased release of P-factor into growth medium" RELATED [PomBase:mah] is_a: FYPO:0000817 ! increased concentration of pheromone in growth medium intersection_of: PATO:0001162 ! increased concentration intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: towards CHEBI:64121 ! P-factor relationship: inheres_in BTO:0000316 ! culture medium relationship: towards CHEBI:64121 ! P-factor created_by: midori creation_date: 2012-03-07T04:14:04Z [Term] id: FYPO:0000820 name: decreased concentration of pheromone in growth medium def: "A phenotype in which the concentration of a peptide pheromone released into the growth medium by cells is lower than normal." [PomBase:mah] synonym: "decreased accumulation of pheromone in growth medium" RELATED [PomBase:mah] synonym: "decreased concentration of peptide pheromone in growth medium" EXACT [PomBase:mah] synonym: "decreased level of pheromone in growth medium" EXACT [PomBase:mah] synonym: "decreased release of pheromone into growth medium" RELATED [PomBase:mah] synonym: "pheromone production: decreased" RELATED [SGD:phenotype_annotation] synonym: "reduced concentration of pheromone in growth medium" EXACT [PomBase:mah] is_a: FYPO:0000816 ! decreased concentration of substance in growth medium intersection_of: PATO:0001163 ! decreased concentration intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: towards CHEBI:38579 ! peptide pheromone relationship: inheres_in BTO:0000316 ! culture medium relationship: towards CHEBI:38579 ! peptide pheromone created_by: midori creation_date: 2012-03-07T04:14:58Z [Term] id: FYPO:0000821 name: decreased concentration of M-factor in growth medium def: "A phenotype in which the concentration of M-factor, the mating pheromone produced by mating type minus cells, released into the growth medium is lower than normal." [PomBase:mah] synonym: "decreased accumulation of M-factor in growth medium" RELATED [PomBase:mah] synonym: "decreased level of M-factor in growth medium" EXACT [PomBase:mah] synonym: "decreased release of M-factor into growth medium" RELATED [PomBase:mah] synonym: "reduced concentration of M-factor in growth medium" EXACT [PomBase:mah] is_a: FYPO:0000820 ! decreased concentration of pheromone in growth medium intersection_of: PATO:0001163 ! decreased concentration intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: towards CHEBI:64120 ! M-factor relationship: inheres_in BTO:0000316 ! culture medium relationship: towards CHEBI:64120 ! M-factor created_by: midori creation_date: 2012-03-07T04:15:08Z [Term] id: FYPO:0000822 name: decreased concentration of P-factor in growth medium def: "A phenotype in which the concentration of P-factor, the mating pheromone produced by mating type plus cells, released into the growth medium is lower than normal." [PomBase:mah] synonym: "decreased accumulation of P-factor in growth medium" RELATED [PomBase:mah] synonym: "decreased level of P-factor in growth medium" EXACT [PomBase:mah] synonym: "decreased release of P-factor into growth medium" RELATED [PomBase:mah] synonym: "reduced concentration of P-factor in growth medium" EXACT [PomBase:mah] is_a: FYPO:0000820 ! decreased concentration of pheromone in growth medium intersection_of: PATO:0001163 ! decreased concentration intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: towards CHEBI:64121 ! P-factor relationship: inheres_in BTO:0000316 ! culture medium relationship: towards CHEBI:64121 ! P-factor created_by: midori creation_date: 2012-03-07T04:15:24Z [Term] id: FYPO:0000824 name: altered RNA level def: "A cell phenotype in which the amount of RNA measured in a cell differs from normal. Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "abnormal RNA level" EXACT [PomBase:mah] synonym: "altered cellular mRNA level" NARROW [PomBase:vw] synonym: "altered cellular RNA level" EXACT [PomBase:mah] synonym: "RNA accumulation: abnormal" RELATED [SGD:phenotype_annotation] is_a: FYPO:0000989 ! altered level of substance in cell intersection_of: PATO:0001159 ! concentrated intersection_of: inheres_in CL:0000000 ! cell intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: inheres_in CL:0000000 ! cell relationship: output_of FYPO:0000142 ! gene expression phenotype relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2012-03-08T03:02:56Z [Term] id: FYPO:0000825 name: increased RNA level during vegetative growth alt_id: FYPO:0000910 alt_id: FYPO:0001247 def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell is higher than normal. Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased cellular RNA level during vegetative growth" EXACT [PomBase:mah] synonym: "increased RNA accumulation during vegetative growth" RELATED [PomBase:mah] synonym: "increased RNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased RNA level during vegetative growth" EXACT [PomBase:mah] synonym: "increased transcript level during vegetative growth" EXACT [PomBase:vw] synonym: "RNA accumulation during vegetative growth" RELATED [PomBase:mah] synonym: "RNA accumulation: increased during vegetative growth" RELATED [SGD:phenotype_annotation] is_a: FYPO:0001326 ! altered RNA level during vegetative growth is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth is_a: FYPO:0001890 ! increased RNA level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2012-03-08T03:15:26Z [Term] id: FYPO:0000826 name: decreased RNA level def: "A cell phenotype in which the amount of RNA measured in a cell is lower than normal. Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. subset: qc_do_not_manually_annotate synonym: "decreased cellular mRNA level" NARROW [PomBase:vw] synonym: "decreased cellular RNA level" EXACT [PomBase:mah] synonym: "decreased RNA accumulation" RELATED [PomBase:mah] synonym: "decreased transcript level" EXACT [PomBase:vw] synonym: "reduced RNA level" EXACT [PomBase:mah] synonym: "RNA accumulation: decreased" RELATED [SGD:phenotype_annotation] is_a: FYPO:0000824 ! altered RNA level is_a: FYPO:0000991 ! decreased level of substance in cell intersection_of: PATO:0001163 ! decreased concentration intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2012-03-08T03:16:30Z [Term] id: FYPO:0000827 name: advanced cell cycle phase transition def: "A cellular process phenotype in which one or more cell cycle phase transitions begins earlier than normal." [PomBase:mah] synonym: "advanced cell cycle phase transition during mitotic cell cycle" RELATED [PomBase:mah] synonym: "advanced cell cycle phase transition during vegetative growth" EXACT [PomBase:mah] synonym: "advanced cell cycle progression" EXACT [PomBase:mah] synonym: "advanced cell cycle progression during vegetative growth" EXACT [PomBase:mah] synonym: "premature cell cycle phase transition" EXACT [PomBase:mah] is_a: FYPO:0000011 ! abnormal cell cycle is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: PATO:0000694 ! premature intersection_of: PATO:0000694 ! premature intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0044770 ! cell cycle phase transition relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0044770 ! cell cycle phase transition created_by: midori creation_date: 2012-03-08T03:30:50Z [Term] id: FYPO:0000828 name: advanced mitotic G1 phase entry def: "A cellular process phenotype in which entry into the G1 phase of the mitotic cell cycle (exit from mitosis) begins earlier than normal." [PomBase:mah] synonym: "accelerated entry into G1" RELATED [PomBase:al] synonym: "advanced exit from mitosis" EXACT [PomBase:mah] synonym: "advanced mitotic G1 phase entry during vegetative growth" EXACT [PomBase:mah] synonym: "advanced mitotic G1 progression" RELATED [PomBase:mah] synonym: "mitotic cell cycle advance in G1" RELATED [PomBase:mah] synonym: "premature exit from mitosis" EXACT [PomBase:mah] synonym: "premature mitotic G1 phase entry" EXACT [PomBase:mah] is_a: FYPO:0000602 ! abnormal mitotic G1 phase progression is_a: FYPO:0000827 ! advanced cell cycle phase transition intersection_of: PATO:0000694 ! premature intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0010458 ! exit from mitosis relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0010458 ! exit from mitosis created_by: midori creation_date: 2012-03-08T03:30:59Z [Term] id: FYPO:0000829 name: resistance to cisplatin def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of cisplatin than normal." [PomBase:mah] synonym: "resistance to cis-DPP" EXACT [CHEBI:27899] synonym: "resistance to cisplatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to cisplatin during vegetative growth" EXACT [PomBase:mah] synonym: "resistance to DPP" BROAD [CHEBI:27899] synonym: "resistant to cisplatin" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:27899 ! cisplatin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:27899 ! cisplatin created_by: midori creation_date: 2012-03-08T03:43:33Z [Term] id: FYPO:0000830 name: resistance to vanadate def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of vanadate ions than normal." [PomBase:mah] synonym: "resistance to vanadate during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to vanadate during vegetative growth" EXACT [PomBase:mah] synonym: "resistance to vanadium oxoanion" EXACT [CHEBI:30528] synonym: "resistant to vanadate" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:30528 ! vanadium oxoanion relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:30528 ! vanadium oxoanion created_by: midori creation_date: 2012-03-08T03:44:55Z [Term] id: FYPO:0000831 name: resistance to actinomycin D def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of actinomycin D than normal." [PomBase:mah] synonym: "resistance to actinomycin D during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to actinomycin D during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to actinomycin D" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:27666 ! actinomycin D relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:27666 ! actinomycin D created_by: midori creation_date: 2012-03-08T03:46:56Z [Term] id: FYPO:0000832 name: elongated nucleus def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the nucleus is longer than normal." [PomBase:mah] synonym: "elongated nuclei" EXACT [PomBase:vw] synonym: "elongated nucleus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "elongated nucleus during vegetative growth" EXACT [PomBase:mah] synonym: "long nucleus" EXACT [PomBase:vw] is_a: FYPO:0000344 ! enlarged nucleus during vegetative growth is_a: PATO:0000573 ! increased length intersection_of: PATO:0000573 ! increased length intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005634 ! nucleus relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005634 ! nucleus created_by: midori creation_date: 2012-03-09T03:40:40Z [Term] id: FYPO:0000833 name: normal protein level during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell is normal (i.e. indistinguishable from wild type). Total protein or a specific protein may be affected." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal cellular protein level during nitrogen starvation" EXACT [PomBase:mah] synonym: "normal protein accumulation during nitrogen starvation" RELATED [PomBase:mah] synonym: "normal protein level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein level during nitrogen depletion" EXACT [PomBase:vw] synonym: "normal protein level during nitrogen deprivation" EXACT [PomBase:vw] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth is_a: FYPO:0004083 ! normal protein level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2012-03-09T03:50:03Z [Term] id: FYPO:0000834 name: altered protein level def: "A cell phenotype in which the amount of protein measured in a cell differs from normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. subset: qc_do_not_manually_annotate synonym: "abnormal protein level" EXACT [PomBase:mah] synonym: "altered cellular protein level" EXACT [PomBase:mah] synonym: "protein/peptide accumulation: abnormal" RELATED [SGD:phenotype_annotation] is_a: FYPO:0000989 ! altered level of substance in cell intersection_of: PATO:0001159 ! concentrated intersection_of: inheres_in CL:0000000 ! cell intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:36080 ! protein relationship: inheres_in CL:0000000 ! cell relationship: output_of FYPO:0000142 ! gene expression phenotype relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2012-03-09T03:50:50Z [Term] id: FYPO:0000835 name: decreased protein level def: "A cell phenotype in which the amount of protein measured in a cell is lower than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. subset: qc_do_not_manually_annotate synonym: "decreased protein accumulation" RELATED [PomBase:mah] synonym: "protein/peptide accumulation: decreased" RELATED [SGD:phenotype_annotation] synonym: "reduced protein level" EXACT [PomBase:mah] is_a: FYPO:0000834 ! altered protein level is_a: FYPO:0000991 ! decreased level of substance in cell intersection_of: PATO:0001163 ! decreased concentration intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:36080 ! protein relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2012-03-09T03:50:57Z [Term] id: FYPO:0000836 name: increased protein level def: "A cell phenotype in which the amount of protein measured in a cell is higher than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. subset: qc_do_not_manually_annotate synonym: "increased protein accumulation" RELATED [PomBase:mah] synonym: "protein/peptide accumulation: increased" RELATED [SGD:phenotype_annotation] is_a: FYPO:0000834 ! altered protein level is_a: FYPO:0000990 ! increased level of substance in cell intersection_of: PATO:0001162 ! increased concentration intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:36080 ! protein relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2012-03-09T03:51:05Z [Term] id: FYPO:0000837 name: cell cycle arrest in mitotic interphase def: "A cellular process phenotype in which progression through the mitotic cell cycle is arrested in any part of interphase. Includes normal and abnormal occurrences of arrest." [PomBase:mah] synonym: "cell cycle arrest in mitotic interphase during vegetative growth" EXACT [PomBase:mah] synonym: "mitotic cell cycle arrest in interphase" EXACT [PomBase:mah] synonym: "mitotic interphase cell cycle arrest" EXACT [PomBase:mah] is_a: FYPO:0004040 ! mitotic cell cycle arrest phenotype intersection_of: FYPO:0001024 ! cell cycle arrest phenotype intersection_of: during GO:0051329 ! mitotic interphase intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071850 ! mitotic cell cycle arrest intersection_of: qualifier PATO:0000467 ! present relationship: during GO:0051329 ! mitotic interphase relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071850 ! mitotic cell cycle arrest relationship: qualifier PATO:0000467 ! present created_by: midori creation_date: 2012-03-09T04:18:58Z [Term] id: FYPO:0000838 name: normal protein localization to nucleus def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleus is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to nucleus" EXACT [PomBase:mah] synonym: "normal protein localization to nucleus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to nucleus during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000644 ! normal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034504 ! protein localization to nucleus intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034504 ! protein localization to nucleus relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-03-12T03:24:23Z [Term] id: FYPO:0000839 name: inviable elongated mononucleate aseptate cell def: "A cell phenotype in which a cell contains one nucleus, has no septum, is elongated, and is inviable." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "elongated mononucleate aseptate cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable elongated mononucleate aseptate cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "long aseptate mononucleate cell" EXACT [PomBase:vw] is_a: FYPO:0002066 ! inviable elongated aseptate cell is_a: FYPO:0003763 ! inviable aseptate mononucleate vegetative cell is_a: FYPO:0004255 ! inviable elongated mononucleate vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000060 ! mononucleate vegetative cell intersection_of: has_part FYPO:0000949 ! aseptate intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000060 ! mononucleate vegetative cell relationship: has_part FYPO:0000949 ! aseptate relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2012-03-12T03:25:38Z [Term] id: FYPO:0000840 name: normal RNA level def: "A cell phenotype in which the amount of RNA measured in a cell is normal (i.e. indistinguishable from wild type). Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "normal cellular RNA level" EXACT [PomBase:mah] synonym: "normal mRNA level" NARROW [PomBase:mah] synonym: "RNA accumulation: normal" RELATED [SGD:phenotype_annotation] is_a: FYPO:0001076 ! normal level of substance in cell intersection_of: PATO:0001159 ! concentrated intersection_of: inheres_in CL:0000000 ! cell intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: inheres_in CL:0000000 ! cell relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2012-03-14T12:06:03Z [Term] id: FYPO:0000841 name: sensitive to sodium dodecyl sulfate def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to sodium dodecyl sulfate (SDS). Cells stop growing (and may die) at a concentration of SDS that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to sodium dodecyl sulfate" EXACT [PomBase:mah] synonym: "sensitive to SDS" EXACT [CHEBI:8984] synonym: "sensitive to sodium dodecyl sulfate during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to sodium dodecyl sulfate during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to sodium dodecyl sulphate" EXACT [CHEBI:8984] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:8984 ! sodium dodecyl sulfate relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:8984 ! sodium dodecyl sulfate created_by: midori creation_date: 2012-03-14T01:14:35Z [Term] id: FYPO:0000842 name: sensitive to ethanol def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to ethanol. Cells stop growing (and may die) at a concentration of ethanol that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to ethanol" EXACT [PomBase:mah] synonym: "sensitive to ethanol during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to ethanol during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to ethyl alcohol" EXACT [CHEBI:16236] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:16236 ! ethanol relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:16236 ! ethanol created_by: midori creation_date: 2012-03-14T01:25:07Z [Term] id: FYPO:0000843 name: sensitive to dithiothreitol def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to 1,4-dithiothreitol (DTT). Cells stop growing (and may die) at a concentration of dithiothreitol that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to dithiothreitol" EXACT [PomBase:mah] synonym: "sensitive to 1,4-dithiothreitol" EXACT [CHEBI:18320] synonym: "sensitive to dithiothreitol during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to dithiothreitol during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to DTT" EXACT [PomBase:al] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:18320 ! 1,4-dithiothreitol relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:18320 ! 1,4-dithiothreitol created_by: midori creation_date: 2012-03-14T01:26:35Z [Term] id: FYPO:0000844 name: sensitive to mercaptoethanol def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to mercaptoethanol. Cells stop growing (and may die) at a concentration of mercaptoethanol that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to mercaptoethanol" EXACT [PomBase:mah] synonym: "sensitive to 2-sulfanylethanol" EXACT [CHEBI:41218] synonym: "sensitive to mercaptoethanol during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to mercaptoethanol during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:41218 ! mercaptoethanol relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:41218 ! mercaptoethanol created_by: midori creation_date: 2012-03-14T01:27:55Z [Term] id: FYPO:0000845 name: abnormal protein degradation during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which protein degradation is abnormal. Protein degradation, also known as protein catabolism, is any metabolic process that results in the destruction of the native, active configuration of a protein, with or without the hydrolysis of peptide bonds." [GO:0030163, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein breakdown during vegetative growth" EXACT [GO:0030163, PomBase:mah] synonym: "abnormal protein catabolic process during vegetative growth" EXACT [GO:0030163, PomBase:mah] synonym: "abnormal protein catabolism during vegetative growth" EXACT [GO:0030163, PomBase:mah] synonym: "abnormal protein degradation during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000328 ! abnormal protein metabolic process during vegetative growth is_a: FYPO:0002275 ! abnormal protein degradation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0030163 ! protein catabolic process intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0030163 ! protein catabolic process relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-14T02:33:44Z [Term] id: FYPO:0000846 name: decreased protein degradation during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of protein degradation is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein breakdown during vegetative growth" EXACT [GO:0030163, PomBase:mah] synonym: "decreased protein catabolic process during vegetative growth" EXACT [GO:0030163, PomBase:mah] synonym: "decreased protein catabolism during vegetative growth" EXACT [GO:0030163, PomBase:mah] synonym: "decreased protein degradation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "reduced protein degradation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000845 ! abnormal protein degradation during vegetative growth is_a: FYPO:0002797 ! decreased protein degradation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0030163 ! protein catabolic process relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_output FYPO:0001327 ! increased protein level during vegetative growth relationship: inheres_in GO:0030163 ! protein catabolic process created_by: midori creation_date: 2012-03-14T02:57:05Z [Term] id: FYPO:0000847 name: increased protein degradation during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of protein degradation is increased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein breakdown during vegetative growth" EXACT [GO:0030163] synonym: "increased protein catabolic process during vegetative growth" EXACT [GO:0030163, PomBase:mah] synonym: "increased protein catabolism during vegetative growth" EXACT [GO:0030163, PomBase:mah] synonym: "increased protein degradation during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000845 ! abnormal protein degradation during vegetative growth is_a: FYPO:0002276 ! increased protein degradation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0030163 ! protein catabolic process relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_output FYPO:0001324 ! decreased protein level during vegetative growth relationship: inheres_in GO:0030163 ! protein catabolic process created_by: midori creation_date: 2012-03-14T03:00:52Z [Term] id: FYPO:0000848 name: abnormal chromosome morphology def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of one or more chromosomes is abnormal." [PomBase:mah] comment: Note that an abnormal chromosome organization process may, but does not necessarily, result in abnormal chromosome morphology. synonym: "abnormal chromosome morphology during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal chromosome morphology during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005694 ! chromosome intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005694 ! chromosome relationship: output_of FYPO:0000641 ! abnormal chromosome organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-14T03:09:26Z [Term] id: FYPO:0000849 name: increased cytoplasmic protein level during vegetative growth def: "A cell phenotype in which the amount of protein measured in the cytoplasm of a cell is higher than normal when the cell is in the vegetative growth phase of the life cycle. Total protein or a specific protein may be affected." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "cytoplasmic accumulation of protein" EXACT [PomBase:mah] synonym: "cytoplasmic protein accumulation during vegetative growth" EXACT [PomBase:mah] synonym: "increased cytoplasmic protein level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein level in cytoplasm during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: FYPO:0001327 ! increased protein level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005737 ! cytoplasm intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005737 ! cytoplasm relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2012-03-14T04:24:49Z [Term] id: FYPO:0000850 name: resistance to stress during vegetative growth def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show decreased sensitivity to a stress." [PomBase:mah] synonym: "resistance to stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistant to stress during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001358 ! vegetative cell population growth phenotype is_a: FYPO:0002046 ! resistance to stress created_by: midori creation_date: 2012-03-15T10:55:12Z [Term] id: FYPO:0000851 name: resistance to osmotic stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which cells show decreased sensitivity to osmotic stress." [PomBase:mah] comment: Use this term if you have assayed growth of cells exposed to osmotic stress in culture. If you have assayed the response to osmotic stress at the subcellular or molecular level, consider annotating to 'abnormal cellular response to osmotic stress' (FYPO:0000193). synonym: "resistance to osmotic stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to osmotic stress during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to osmotic stress" EXACT [PomBase:mah] is_a: FYPO:0000850 ! resistance to stress during vegetative growth created_by: midori creation_date: 2012-03-15T10:55:59Z [Term] id: FYPO:0000852 name: resistance to salt stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which cells show decreased sensitivity to a salt stress." [PomBase:mah] synonym: "ionic stress resistance: increased" EXACT [SGD:phenotype_annotation] synonym: "resistance to salt stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistant to salt stress" EXACT [PomBase:mah] synonym: "resistant to salt stress during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000851 ! resistance to osmotic stress created_by: midori creation_date: 2012-03-15T10:56:15Z [Term] id: FYPO:0000853 name: abnormal nucleosome positioning def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which nucleosome positioning is abnormal. Nucleosome positioning is the ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another." [GO:0016584, PomBase:mah] synonym: "abnormal nucleosome positioning during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal nucleosome positioning during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal nucleosome spacing" EXACT [GO:0016584, PomBase:mah] is_a: FYPO:0001352 ! abnormal chromatin organization during vegetative growth is_a: FYPO:0001354 ! abnormal cellular component assembly during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0016584 ! nucleosome positioning intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0016584 ! nucleosome positioning relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-20T11:46:43Z [Term] id: FYPO:0000854 name: abnormal nucleosome positioning in euchromatin def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which nucleosome positioning in regions of euchromatin is abnormal. Nucleosome positioning is the ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another." [GO:0016584, PomBase:mah] synonym: "abnormal nucleosome positioning in euchromatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal nucleosome positioning in euchromatin during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal nucleosome spacing in euchromatin" EXACT [GO:0016584, PomBase:mah] is_a: FYPO:0000853 ! abnormal nucleosome positioning intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0016584 ! nucleosome positioning intersection_of: occurs_in GO:0000791 ! euchromatin intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0016584 ! nucleosome positioning relationship: occurs_in GO:0000791 ! euchromatin relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-20T11:52:16Z [Term] id: FYPO:0000855 name: abnormal nucleosome positioning in heterochromatin def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which nucleosome positioning in regions of heterochromatin is abnormal. Nucleosome positioning is the ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another." [GO:0016584, PomBase:mah] synonym: "abnormal nucleosome positioning in heterochromatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal nucleosome positioning in heterochromatin during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal nucleosome spacing in heterochromatin" EXACT [GO:0016584, PomBase:mah] is_a: FYPO:0000853 ! abnormal nucleosome positioning intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0016584 ! nucleosome positioning intersection_of: occurs_in GO:0000792 ! heterochromatin intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0016584 ! nucleosome positioning relationship: occurs_in GO:0000792 ! heterochromatin relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-20T11:53:31Z [Term] id: FYPO:0000856 name: normal nucleosome positioning def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which nucleosome positioning is normal (i.e. indistinguishable from wild type). Nucleosome positioning is the ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another." [GO:0016584, PomBase:mah] synonym: "normal nucleosome positioning during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal nucleosome positioning during vegetative growth" EXACT [PomBase:mah] synonym: "normal nucleosome spacing" EXACT [GO:0016584, PomBase:mah] is_a: FYPO:0002891 ! normal chromatin organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0016584 ! nucleosome positioning intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0016584 ! nucleosome positioning relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-03-20T11:54:42Z [Term] id: FYPO:0000857 name: normal nucleosome positioning in euchromatin def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which nucleosome positioning in regions of euchromatin is normal (i.e. indistinguishable from wild type). Nucleosome positioning is the ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another." [GO:0016584, PomBase:mah] synonym: "normal nucleosome positioning in euchromatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal nucleosome positioning in euchromatin during vegetative growth" EXACT [PomBase:mah] synonym: "normal nucleosome spacing in euchromatin" EXACT [GO:0016584, PomBase:mah] is_a: FYPO:0000856 ! normal nucleosome positioning intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0016584 ! nucleosome positioning intersection_of: occurs_in GO:0000791 ! euchromatin intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0016584 ! nucleosome positioning relationship: occurs_in GO:0000791 ! euchromatin relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-03-20T11:55:39Z [Term] id: FYPO:0000858 name: normal nucleosome positioning in heterochromatin def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which nucleosome positioning in regions of heterochromatin is normal (i.e. indistinguishable from wild type). Nucleosome positioning is the ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another." [GO:0016584, PomBase:mah] synonym: "normal nucleosome positioning in heterochromatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal nucleosome positioning in heterochromatin during vegetative growth" EXACT [PomBase:mah] synonym: "normal nucleosome spacing in heterochromatin" EXACT [GO:0016584, PomBase:mah] is_a: FYPO:0000856 ! normal nucleosome positioning intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0016584 ! nucleosome positioning intersection_of: occurs_in GO:0000792 ! heterochromatin intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0016584 ! nucleosome positioning relationship: occurs_in GO:0000792 ! heterochromatin relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-03-20T11:55:49Z [Term] id: FYPO:0000859 name: normal metabolic process during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which a cellular metabolic process is normal (i.e. indistinguishable from wild type). A metabolic process is any set of chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances." [GO:0044237, PomBase:mah] synonym: "normal cellular metabolic process during vegetative growth" EXACT [GO:0044237, PomBase:mah] synonym: "normal metabolic process during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal metabolism during vegetative growth" EXACT [GO:0044237, PomBase:mah] is_a: FYPO:0001319 ! normal cellular process during vegetative growth is_a: FYPO:0001348 ! cellular metabolism phenotype during vegetative growth is_a: FYPO:0002496 ! normal metabolic process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0044237 ! cellular metabolic process intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0044237 ! cellular metabolic process relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-03-20T12:10:04Z [Term] id: FYPO:0000860 name: abnormal metabolic process def: "A cellular process phenotype in which a cellular metabolic process is abnormal. A metabolic process is any set of chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances." [GO:0044237, PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "abnormal cellular metabolic process" EXACT [GO:0044237, PomBase:mah] synonym: "abnormal metabolism" EXACT [GO:0044237, PomBase:mah] is_a: FYPO:0000140 ! cellular metabolism phenotype is_a: FYPO:0000628 ! abnormal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0044237 ! cellular metabolic process intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0044237 ! cellular metabolic process relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-20T12:11:59Z [Term] id: FYPO:0000861 name: normal histone methylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone methylation is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal histone methylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal histone methylation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002600 ! normal histone modification intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0016571 ! histone methylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0016571 ! histone methylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-03-20T12:15:03Z [Term] id: FYPO:0000862 name: normal histone H3-K9 dimethylation at centromere def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the dimethylation of lysine at position 9 of histone H3 in centromeric regions is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal centromeric histone H3-K9 dimethylation " EXACT [PomBase:mah] synonym: "normal histone H3-K9 dimethylation at centromere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal histone H3-K9 dimethylation at centromere during vegetative growth" EXACT [PomBase:mah] synonym: "normal histone H3K9me2 at centromere" EXACT [PomBase:mah] is_a: FYPO:0000861 ! normal histone methylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0016571 ! histone methylation intersection_of: occurs_at SO:0001795 ! regional_centromere intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0016571 ! histone methylation relationship: occurs_at SO:0001795 ! regional_centromere relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-03-20T12:18:40Z [Term] id: FYPO:0000863 name: normal histone H3-K9 dimethylation at centromere inner repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the dimethylation of lysine at position 9 of histone H3 in centromere inner repeat regions is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal histone H3-K9 dimethylation at centromere inner repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal histone H3-K9 dimethylation at centromere inner repeat during vegetative growth" EXACT [PomBase:mah] synonym: "normal histone H3-K9 dimethylation at centromere inner repeat region" EXACT [PomBase:mah] synonym: "normal histone H3-K9 dimethylation at imr" EXACT [PomBase:mah, SO:0001798] synonym: "normal histone H3K9me2 at centromere inner repeat" EXACT [PomBase:mah] is_a: FYPO:0000862 ! normal histone H3-K9 dimethylation at centromere is_a: FYPO:0003232 ! normal histone H3-K9 methylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0036123 ! histone H3-K9 dimethylation intersection_of: occurs_at SO:0001798 ! regional_centromere_inner_repeat_region intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0036123 ! histone H3-K9 dimethylation relationship: occurs_at SO:0001798 ! regional_centromere_inner_repeat_region relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-03-20T12:20:16Z [Term] id: FYPO:0000864 name: abnormal histone H3-K9 trimethylation at centromere def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the trimethylation of lysine at position 9 of histone H3 in centromeric regions is abnormal." [PomBase:mah] synonym: "abnormal centromeric histone H3-K9 trimethylation" EXACT [PomBase:mah] synonym: "abnormal histone H3 K9 trimethylation at centromere" EXACT [GO:0036124, PomBase:mah] synonym: "abnormal histone H3-K9 trimethylation at centromere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal histone H3-K9 trimethylation at centromere during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal histone H3K9 trimethylation at centromere" EXACT [PomBase:vw] synonym: "abnormal histone H3K9me3 at centromere" EXACT [PomBase:mah] synonym: "abnormal histone lysine H3 K9 trimethylation at centromere" EXACT [GO:0036124, PomBase:mah] is_a: FYPO:0000787 ! abnormal histone H3-K9 trimethylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0036124 ! histone H3-K9 trimethylation intersection_of: occurs_at SO:0001795 ! regional_centromere intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0036124 ! histone H3-K9 trimethylation relationship: occurs_at SO:0001795 ! regional_centromere relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-20T12:22:17Z [Term] id: FYPO:0000865 name: abnormal histone H3-K9 trimethylation at centromere inner repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the trimethylation of lysine at position 9 of histone H3 in centromere inner repeat regions is abnormal." [PomBase:mah] synonym: "abnormal histone H3 K9 trimethylation at centromere inner repeat" EXACT [GO:0036124, PomBase:mah] synonym: "abnormal histone H3-K9 trimethylation at centromere inner repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal histone H3-K9 trimethylation at centromere inner repeat during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal histone H3-K9 trimethylation at centromere inner repeat region" EXACT [PomBase:mah] synonym: "abnormal histone H3-K9 trimethylation at imr" EXACT [PomBase:mah, SO:0001798] synonym: "abnormal histone H3K9 trimethylation at centromere inner repeat" EXACT [PomBase:vw] synonym: "abnormal histone H3K9me3 at centromere inner repeat" EXACT [PomBase:mah] synonym: "abnormal histone lysine H3 K9 trimethylation at centromere inner repeat" EXACT [GO:0036124, PomBase:mah] is_a: FYPO:0000864 ! abnormal histone H3-K9 trimethylation at centromere intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0036124 ! histone H3-K9 trimethylation intersection_of: occurs_at SO:0001798 ! regional_centromere_inner_repeat_region intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0036124 ! histone H3-K9 trimethylation relationship: occurs_at SO:0001798 ! regional_centromere_inner_repeat_region relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-20T12:25:24Z [Term] id: FYPO:0000866 name: abnormal histone H3-K9 dimethylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which dimethylation of lysine at position 9 of histone H3 is abnormal." [PomBase:mah] synonym: "abnormal histone H3 K9 dimethylation" EXACT [GO:0036123, PomBase:mah] synonym: "abnormal histone H3-K9 dimethylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal histone H3-K9 dimethylation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal histone H3K9 dimethylation" EXACT [PomBase:vw] synonym: "abnormal histone H3K9me2" EXACT [PomBase:mah] synonym: "abnormal histone lysine H3 K9 dimethylation" EXACT [GO:0036123, PomBase:mah] is_a: FYPO:0000458 ! abnormal histone H3-K9 methylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0036123 ! histone H3-K9 dimethylation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0036123 ! histone H3-K9 dimethylation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-20T12:28:22Z [Term] id: FYPO:0000867 name: abnormal histone H3-K9 dimethylation at centromere def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the dimethylation of lysine at position 9 of histone H3 in centromeric regions is abnormal." [PomBase:mah] synonym: "abnormal centromeric histone H3-K9 dimethylation" EXACT [PomBase:mah] synonym: "abnormal histone H3 K9 dimethylation at centromere" EXACT [GO:0036123, PomBase:mah] synonym: "abnormal histone H3-K9 dimethylation at centromere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal histone H3-K9 dimethylation at centromere during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal histone H3K9 dimethylation at centromere" EXACT [PomBase:vw] synonym: "abnormal histone H3K9me2 at centromere" EXACT [PomBase:mah] synonym: "abnormal histone lysine H3 K9 dimethylation at centromere" EXACT [GO:0036123, PomBase:mah] is_a: FYPO:0000866 ! abnormal histone H3-K9 dimethylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0036123 ! histone H3-K9 dimethylation intersection_of: occurs_at SO:0001795 ! regional_centromere intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0036123 ! histone H3-K9 dimethylation relationship: occurs_at SO:0001795 ! regional_centromere relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-20T12:29:39Z [Term] id: FYPO:0000868 name: abnormal histone H3-K9 dimethylation at centromere inner repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the dimethylation of lysine at position 9 of histone H3 in centromere inner repeat regions is abnormal." [PomBase:mah] synonym: "abnormal histone H3 K9 dimethylation at centromere inner repeat" EXACT [GO:0036123, PomBase:mah] synonym: "abnormal histone H3-K9 dimethylation at centromere inner repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal histone H3-K9 dimethylation at centromere inner repeat during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal histone H3-K9 dimethylation at centromere inner repeat region" EXACT [PomBase:mah] synonym: "abnormal histone H3-K9 dimethylation at imr" EXACT [PomBase:vw] synonym: "abnormal histone H3K9 dimethylation at centromere inner repeat" EXACT [PomBase:vw] synonym: "abnormal histone H3K9me2 at centromere inner repeat" EXACT [PomBase:mah] synonym: "abnormal histone lysine H3 K9 dimethylation at centromere inner repeat" EXACT [GO:0036123, PomBase:mah] is_a: FYPO:0000867 ! abnormal histone H3-K9 dimethylation at centromere intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0036123 ! histone H3-K9 dimethylation intersection_of: occurs_at SO:0001798 ! regional_centromere_inner_repeat_region intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0036123 ! histone H3-K9 dimethylation relationship: occurs_at SO:0001798 ! regional_centromere_inner_repeat_region relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-20T12:29:52Z [Term] id: FYPO:0000869 name: increased histone methylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone methylation occurs to a greater extent than normal. All histone methylation may be affected, or methylation of specific sites on specific histones may be increased." [PomBase:mah] synonym: "increased histone methylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone methylation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000457 ! abnormal histone methylation is_a: FYPO:0000547 ! increased protein modification during vegetative growth intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0016571 ! histone methylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0016571 ! histone methylation created_by: midori creation_date: 2012-03-20T12:32:05Z [Term] id: FYPO:0000870 name: decreased histone methylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone methylation occurs to a lower extent than normal. All histone methylation may be affected, or methylation of specific sites on specific histones may be decreased." [PomBase:mah] synonym: "decreased histone methylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone methylation during vegetative growth" EXACT [PomBase:mah] synonym: "reduced histone methylation" EXACT [PomBase:mah] is_a: FYPO:0000457 ! abnormal histone methylation is_a: FYPO:0000545 ! decreased protein modification during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0016571 ! histone methylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0016571 ! histone methylation created_by: midori creation_date: 2012-03-20T12:32:18Z [Term] id: FYPO:0000871 name: increased histone H3-K9 methylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which methylation of lysine at position 9 of histone H3 occurs to a greater extent than normal." [PomBase:mah] synonym: "increased histone H3 K9 methylation" EXACT [GO:0051567, PomBase:mah] synonym: "increased histone H3-K9 methylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H3-K9 methylation during vegetative growth" EXACT [PomBase:mah] synonym: "increased histone H3K9me" EXACT [GO:0051567, PomBase:mah] synonym: "increased histone lysine H3 K9 methylation" EXACT [GO:0051567, PomBase:mah] is_a: FYPO:0000458 ! abnormal histone H3-K9 methylation is_a: FYPO:0000869 ! increased histone methylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051567 ! histone H3-K9 methylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051567 ! histone H3-K9 methylation created_by: midori creation_date: 2012-03-20T12:33:11Z [Term] id: FYPO:0000872 name: decreased histone H3-K9 methylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which methylation of lysine at position 9 of histone H3 occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased histone H3 K9 methylation" EXACT [GO:0051567, PomBase:mah] synonym: "decreased histone H3-K9 methylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H3-K9 methylation during vegetative growth" EXACT [PomBase:mah] synonym: "decreased histone H3K9me" EXACT [GO:0051567, PomBase:mah] synonym: "decreased histone lysine H3 K9 methylation" EXACT [GO:0051567, PomBase:mah] synonym: "reduced histone H3-K9 methylation" EXACT [PomBase:mah] is_a: FYPO:0000870 ! decreased histone methylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051567 ! histone H3-K9 methylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051567 ! histone H3-K9 methylation created_by: midori creation_date: 2012-03-20T12:34:25Z [Term] id: FYPO:0000873 name: increased histone H3-K9 dimethylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which dimethylation of lysine at position 9 of histone H3 occurs to a greater extent than normal." [PomBase:mah] synonym: "increased histone H3 K9 dimethylation" EXACT [GO:0036123, PomBase:mah] synonym: "increased histone H3-K9 dimethylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H3-K9 dimethylation during vegetative growth" EXACT [PomBase:mah] synonym: "increased histone H3K9 dimethylation" EXACT [PomBase:vw] synonym: "increased histone H3K9me2" EXACT [PomBase:mah] synonym: "increased histone lysine H3 K9 dimethylation" EXACT [GO:0036123, PomBase:mah] is_a: FYPO:0000866 ! abnormal histone H3-K9 dimethylation is_a: FYPO:0000871 ! increased histone H3-K9 methylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0036123 ! histone H3-K9 dimethylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0036123 ! histone H3-K9 dimethylation created_by: midori creation_date: 2012-03-20T01:25:01Z [Term] id: FYPO:0000874 name: increased histone H3-K9 dimethylation at centromere def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the dimethylation of lysine at position 9 of histone H3 in centromeric regions occurs to a greater extent than normal." [PomBase:mah] synonym: "increased centromeric histone H3-K9 dimethylation" EXACT [PomBase:mah] synonym: "increased histone H3 K9 dimethylation at centromere" EXACT [GO:0036123, PomBase:mah] synonym: "increased histone H3-K9 dimethylation at centromere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H3-K9 dimethylation at centromere during vegetative growth" EXACT [PomBase:mah] synonym: "increased histone H3K9 dimethylation at centromere" EXACT [PomBase:vw] synonym: "increased histone H3K9me2 at centromere" EXACT [PomBase:mah] synonym: "increased histone lysine H3 K9 dimethylation at centromere" EXACT [GO:0036123, PomBase:mah] is_a: FYPO:0000867 ! abnormal histone H3-K9 dimethylation at centromere is_a: FYPO:0000873 ! increased histone H3-K9 dimethylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0036123 ! histone H3-K9 dimethylation intersection_of: occurs_at SO:0001795 ! regional_centromere relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0036123 ! histone H3-K9 dimethylation relationship: occurs_at SO:0001795 ! regional_centromere created_by: midori creation_date: 2012-03-20T01:25:10Z [Term] id: FYPO:0000875 name: increased histone H3-K9 dimethylation at centromere inner repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the dimethylation of lysine at position 9 of histone H3 in centromere inner repeat regions occurs to a greater extent than normal." [PomBase:mah] synonym: "increased histone H3 K9 dimethylation at centromere inner repeat" EXACT [GO:0036123, PomBase:mah] synonym: "increased histone H3-K9 dimethylation at centromere inner repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H3-K9 dimethylation at centromere inner repeat during vegetative growth" EXACT [PomBase:mah] synonym: "increased histone H3-K9 dimethylation at centromere inner repeat region" EXACT [PomBase:mah] synonym: "increased histone H3-K9 dimethylation at imr" EXACT [PomBase:mah, SO:0001798] synonym: "increased histone H3K9 dimethylation at centromere inner repeat" EXACT [PomBase:vw] synonym: "increased histone H3K9me2 at centromere inner repeat" EXACT [PomBase:mah] synonym: "increased histone lysine H3 K9 dimethylation at centromere inner repeat" EXACT [GO:0036123, PomBase:mah] is_a: FYPO:0000868 ! abnormal histone H3-K9 dimethylation at centromere inner repeat is_a: FYPO:0000874 ! increased histone H3-K9 dimethylation at centromere intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0036123 ! histone H3-K9 dimethylation intersection_of: occurs_at SO:0001798 ! regional_centromere_inner_repeat_region relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0036123 ! histone H3-K9 dimethylation relationship: occurs_at SO:0001798 ! regional_centromere_inner_repeat_region created_by: midori creation_date: 2012-03-20T01:25:53Z [Term] id: FYPO:0000876 name: decreased histone H3-K9 dimethylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which dimethylation of lysine at position 9 of histone H3 occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased histone H3 K9 dimethylation" EXACT [GO:0036123, PomBase:mah] synonym: "decreased histone H3-K9 dimethylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H3-K9 dimethylation during vegetative growth" EXACT [PomBase:mah] synonym: "decreased histone H3K9 dimethylation" EXACT [PomBase:vw] synonym: "decreased histone H3K9me2" EXACT [PomBase:mah] synonym: "decreased histone lysine H3 K9 dimethylation" EXACT [GO:0036123, PomBase:mah] synonym: "reduced histone H3-K9 dimethylation" EXACT [PomBase:mah] is_a: FYPO:0000866 ! abnormal histone H3-K9 dimethylation is_a: FYPO:0000872 ! decreased histone H3-K9 methylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0036123 ! histone H3-K9 dimethylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0036123 ! histone H3-K9 dimethylation created_by: midori creation_date: 2012-03-20T01:35:21Z [Term] id: FYPO:0000877 name: decreased histone H3-K9 dimethylation at centromere def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the dimethylation of lysine at position 9 of histone H3 in centromeric regions occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased centromeric histone H3-K9 dimethylation" EXACT [PomBase:mah] synonym: "decreased histone H3 K9 dimethylation at centromere" EXACT [GO:0036123, PomBase:mah] synonym: "decreased histone H3-K9 dimethylation at centromere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H3-K9 dimethylation at centromere during vegetative growth" EXACT [PomBase:mah] synonym: "decreased histone H3K9 dimethylation at centromere" EXACT [PomBase:vw] synonym: "decreased histone H3K9me2 at centromere" EXACT [PomBase:mah] synonym: "decreased histone lysine H3 K9 dimethylation at centromere" EXACT [GO:0036123, PomBase:mah] synonym: "reduced histone H3-K9 dimethylation at centromere" EXACT [PomBase:mah] is_a: FYPO:0000867 ! abnormal histone H3-K9 dimethylation at centromere is_a: FYPO:0000876 ! decreased histone H3-K9 dimethylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0036123 ! histone H3-K9 dimethylation intersection_of: occurs_at SO:0001795 ! regional_centromere relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0036123 ! histone H3-K9 dimethylation relationship: occurs_at SO:0001795 ! regional_centromere created_by: midori creation_date: 2012-03-20T01:36:04Z [Term] id: FYPO:0000878 name: decreased histone H3-K9 dimethylation at centromere inner repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the dimethylation of lysine at position 9 of histone H3 in centromere inner repeat regions occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased histone H3 K9 dimethylation at centromere inner repeat" EXACT [GO:0036123, PomBase:mah] synonym: "decreased histone H3-K9 dimethylation at centromere inner repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H3-K9 dimethylation at centromere inner repeat during vegetative growth" EXACT [PomBase:mah] synonym: "decreased histone H3-K9 dimethylation at centromere inner repeat region" EXACT [PomBase:mah] synonym: "decreased histone H3-K9 dimethylation at imr" EXACT [PomBase:mah, SO:0001798] synonym: "decreased histone H3K9 dimethylation at centromere inner repeat" EXACT [PomBase:vw] synonym: "decreased histone H3K9me2 at centromere inner repeat" EXACT [PomBase:mah] synonym: "reduced histone H3-K9 dimethylation at centromere inner repeat" EXACT [PomBase:mah] synonym: "v histone lysine H3 K9 dimethylation at centromere inner repeat" EXACT [GO:0036123, PomBase:mah] is_a: FYPO:0000868 ! abnormal histone H3-K9 dimethylation at centromere inner repeat is_a: FYPO:0000877 ! decreased histone H3-K9 dimethylation at centromere intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0036123 ! histone H3-K9 dimethylation intersection_of: occurs_at SO:0001798 ! regional_centromere_inner_repeat_region relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0036123 ! histone H3-K9 dimethylation relationship: occurs_at SO:0001798 ! regional_centromere_inner_repeat_region created_by: midori creation_date: 2012-03-20T01:36:23Z [Term] id: FYPO:0000879 name: increased histone H3-K9 trimethylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which trimethylation of lysine at position 9 of histone H3 occurs to a greater extent than normal." [PomBase:mah] synonym: "increased histone H3 K9 trimethylation" EXACT [GO:0036124, PomBase:mah] synonym: "increased histone H3-K9 trimethylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H3-K9 trimethylation during vegetative growth" EXACT [PomBase:mah] synonym: "increased histone H3K9 trimethylation" EXACT [PomBase:vw] synonym: "increased histone H3K9me3" EXACT [PomBase:mah] synonym: "increased histone lysine H3 K9 trimethylation" EXACT [GO:0036124, PomBase:mah] is_a: FYPO:0000787 ! abnormal histone H3-K9 trimethylation is_a: FYPO:0000871 ! increased histone H3-K9 methylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0036124 ! histone H3-K9 trimethylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0036124 ! histone H3-K9 trimethylation created_by: midori creation_date: 2012-03-20T01:42:40Z [Term] id: FYPO:0000880 name: increased histone H3-K9 trimethylation at centromere def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the trimethylation of lysine at position 9 of histone H3 in centromeric regions occurs to a greater extent than normal." [PomBase:mah] synonym: "increased centromeric histone H3-K9 trimethylation" EXACT [PomBase:mah] synonym: "increased histone H3 K9 trimethylation at centromere" EXACT [GO:0036124, PomBase:mah] synonym: "increased histone H3-K9 trimethylation at centromere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H3-K9 trimethylation at centromere during vegetative growth" EXACT [PomBase:mah] synonym: "increased histone H3K9 trimethylation at centromere" EXACT [PomBase:vw] synonym: "increased histone H3K9me3 at centromere" EXACT [PomBase:mah] synonym: "increased histone lysine H3 K9 trimethylation at centromere" EXACT [GO:0036124, PomBase:mah] is_a: FYPO:0000864 ! abnormal histone H3-K9 trimethylation at centromere is_a: FYPO:0000879 ! increased histone H3-K9 trimethylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0036124 ! histone H3-K9 trimethylation intersection_of: occurs_at SO:0001795 ! regional_centromere relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0036124 ! histone H3-K9 trimethylation relationship: occurs_at SO:0001795 ! regional_centromere created_by: midori creation_date: 2012-03-20T01:42:53Z [Term] id: FYPO:0000881 name: increased histone H3-K9 trimethylation at centromere inner repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the trimethylation of lysine at position 9 of histone H3 in centromere inner repeat regions occurs to a greater extent than normal." [PomBase:mah] synonym: "increased histone H3 K9 trimethylation at centromere inner repeat" EXACT [GO:0036124, PomBase:mah] synonym: "increased histone H3-K9 trimethylation at centromere inner repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H3-K9 trimethylation at centromere inner repeat during vegetative growth" EXACT [PomBase:mah] synonym: "increased histone H3-K9 trimethylation at centromere inner repeat region" EXACT [PomBase:mah] synonym: "increased histone H3-K9 trimethylation at imr" EXACT [PomBase:mah, SO:0001798] synonym: "increased histone H3K9 trimethylation at centromere inner repeat" EXACT [PomBase:vw] synonym: "increased histone H3K9me3 at centromere inner repeat" EXACT [PomBase:mah] synonym: "increased histone lysine H3 K9 trimethylation at centromere inner repeat" EXACT [GO:0036124, PomBase:mah] is_a: FYPO:0000865 ! abnormal histone H3-K9 trimethylation at centromere inner repeat is_a: FYPO:0000880 ! increased histone H3-K9 trimethylation at centromere intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0036124 ! histone H3-K9 trimethylation intersection_of: occurs_at SO:0001798 ! regional_centromere_inner_repeat_region relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0036124 ! histone H3-K9 trimethylation relationship: occurs_at SO:0001798 ! regional_centromere_inner_repeat_region created_by: midori creation_date: 2012-03-20T01:43:01Z [Term] id: FYPO:0000882 name: decreased histone H3-K9 trimethylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which trimethylation of lysine at position 9 of histone H3 occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased histone H3 K9 trimethylation" EXACT [GO:0036124, PomBase:mah] synonym: "decreased histone H3-K9 trimethylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H3-K9 trimethylation during vegetative growth" EXACT [PomBase:mah] synonym: "decreased histone H3K9 trimethylation" EXACT [PomBase:vw] synonym: "decreased histone H3K9me3" EXACT [PomBase:mah] synonym: "decreased histone lysine H3 K9 trimethylation" EXACT [GO:0036124, PomBase:mah] synonym: "reduced histone H3-K9 trimethylation" EXACT [PomBase:mah] is_a: FYPO:0000787 ! abnormal histone H3-K9 trimethylation is_a: FYPO:0000872 ! decreased histone H3-K9 methylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0036124 ! histone H3-K9 trimethylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0036124 ! histone H3-K9 trimethylation created_by: midori creation_date: 2012-03-20T01:47:31Z [Term] id: FYPO:0000883 name: decreased histone H3-K9 trimethylation at centromere def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the trimethylation of lysine at position 9 of histone H3 in centromeric regions occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased centromeric histone H3-K9 trimethylation" EXACT [PomBase:mah] synonym: "decreased histone H3 K9 trimethylation at centromere" EXACT [GO:0036124, PomBase:mah] synonym: "decreased histone H3-K9 trimethylation at centromere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H3-K9 trimethylation at centromere during vegetative growth" EXACT [PomBase:mah] synonym: "decreased histone H3K9 trimethylation at centromere" EXACT [PomBase:vw] synonym: "decreased histone H3K9me3 at centromere" EXACT [PomBase:mah] synonym: "decreased histone lysine H3 K9 trimethylation at centromere" EXACT [GO:0036124, PomBase:mah] synonym: "reduced histone H3-K9 trimethylation at centromere" EXACT [PomBase:mah] is_a: FYPO:0000864 ! abnormal histone H3-K9 trimethylation at centromere is_a: FYPO:0000882 ! decreased histone H3-K9 trimethylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0036124 ! histone H3-K9 trimethylation intersection_of: occurs_at SO:0001795 ! regional_centromere relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0036124 ! histone H3-K9 trimethylation relationship: occurs_at SO:0001795 ! regional_centromere created_by: midori creation_date: 2012-03-20T01:47:38Z [Term] id: FYPO:0000884 name: decreased histone H3-K9 trimethylation at centromere inner repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the trimethylation of lysine at position 9 of histone H3 in centromere inner repeat regions occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased histone H3 K9 trimethylation at centromere inner repeat" EXACT [GO:0036124, PomBase:mah] synonym: "decreased histone H3-K9 trimethylation at centromere inner repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H3-K9 trimethylation at centromere inner repeat during vegetative growth" EXACT [PomBase:mah] synonym: "decreased histone H3-K9 trimethylation at centromere inner repeat region" EXACT [PomBase:mah] synonym: "decreased histone H3-K9 trimethylation at imr" EXACT [PomBase:mah, SO:0001798] synonym: "decreased histone H3K9 trimethylation at centromere inner repeat" EXACT [PomBase:vw] synonym: "decreased histone H3K9me3 at centromere inner repeat" EXACT [PomBase:mah] synonym: "decreased histone lysine H3 K9 trimethylation at centromere inner repeat" EXACT [GO:0036124, PomBase:mah] synonym: "reduced histone H3-K9 trimethylation at centromere inner repeat" EXACT [PomBase:mah] is_a: FYPO:0000865 ! abnormal histone H3-K9 trimethylation at centromere inner repeat is_a: FYPO:0000883 ! decreased histone H3-K9 trimethylation at centromere intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0036124 ! histone H3-K9 trimethylation intersection_of: occurs_at SO:0001798 ! regional_centromere_inner_repeat_region relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0036124 ! histone H3-K9 trimethylation relationship: occurs_at SO:0001798 ! regional_centromere_inner_repeat_region created_by: midori creation_date: 2012-03-20T01:47:46Z [Term] id: FYPO:0000885 name: abnormal histone H3-K9 trimethylation at centromere outer repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the trimethylation of lysine at position 9 of histone H3 in centromere outer repeat regions is abnormal." [PomBase:mah] synonym: "abnormal histone H3 K9 trimethylation at centromere outer repeat" EXACT [GO:0036124, PomBase:mah] synonym: "abnormal histone H3-K9 trimethylation at centromere otr" EXACT [PomBase:mah] synonym: "abnormal histone H3-K9 trimethylation at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal histone H3-K9 trimethylation at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal histone H3-K9 trimethylation at centromeric outer repeat region" EXACT [PomBase:mah] synonym: "abnormal histone H3-K9 trimethylation at pericentric region" RELATED [PomBase:mah] synonym: "abnormal histone H3-K9 trimethylation at pericentromeric region" RELATED [PomBase:mah] synonym: "abnormal histone H3K9 trimethylation at centromere outer repeat" EXACT [PomBase:vw] synonym: "abnormal histone H3K9me3 at centromere outer repeat" EXACT [PomBase:mah] synonym: "abnormal histone lysine H3 K9 trimethylation at centromere outer repeat" EXACT [GO:0036124, PomBase:mah] is_a: FYPO:0000864 ! abnormal histone H3-K9 trimethylation at centromere intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0036124 ! histone H3-K9 trimethylation intersection_of: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0036124 ! histone H3-K9 trimethylation relationship: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-20T12:25:24Z [Term] id: FYPO:0000886 name: abnormal histone H3-K9 dimethylation at centromere outer repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the dimethylation of lysine at position 9 of histone H3 in centromere outer repeat regions is abnormal." [PomBase:mah] synonym: "abnormal histone H3 K9 dimethylation at centromere outer repeat" EXACT [GO:0036123, PomBase:mah] synonym: "abnormal histone H3-K9 dimethylation at centromere otr" EXACT [PomBase:mah] synonym: "abnormal histone H3-K9 dimethylation at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal histone H3-K9 dimethylation at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal histone H3-K9 dimethylation at centromeric outer repeat region" EXACT [PomBase:mah] synonym: "abnormal histone H3-K9 dimethylation at pericentric region" RELATED [PomBase:mah] synonym: "abnormal histone H3-K9 dimethylation at pericentromeric region" RELATED [PomBase:mah] synonym: "abnormal histone H3K9 dimethylation at centromere outer repeat" EXACT [PomBase:vw] synonym: "abnormal histone H3K9me2 at centromere outer repeat" EXACT [PomBase:mah] synonym: "abnormal histone lysine H3 K9 dimethylation at centromere outer repeat" EXACT [GO:0036123, PomBase:mah] is_a: FYPO:0000867 ! abnormal histone H3-K9 dimethylation at centromere intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0036123 ! histone H3-K9 dimethylation intersection_of: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0036123 ! histone H3-K9 dimethylation relationship: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-20T12:29:52Z [Term] id: FYPO:0000887 name: increased histone H3-K9 dimethylation at centromere outer repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the dimethylation of lysine at position 9 of histone H3 in centromere outer repeat regions occurs to a greater extent than normal." [PomBase:mah] synonym: "abnormal histone H3-K9 dimethylation at centromere otr" EXACT [PomBase:mah] synonym: "abnormal histone H3-K9 dimethylation at centromeric outer repeat region" EXACT [PomBase:mah] synonym: "abnormal histone H3-K9 dimethylation at pericentric region" RELATED [PomBase:mah] synonym: "abnormal histone H3-K9 dimethylation at pericentromeric region" RELATED [PomBase:mah] synonym: "increased histone H3 K9 dimethylation at centromere outer repeat" EXACT [GO:0036123, PomBase:mah] synonym: "increased histone H3-K9 dimethylation at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H3-K9 dimethylation at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] synonym: "increased histone H3K9 dimethylation at centromere outer repeat" EXACT [PomBase:vw] synonym: "increased histone H3K9me2 at centromere outer repeat" EXACT [PomBase:mah] synonym: "increased histone lysine H3 K9 dimethylation at centromere outer repeat" EXACT [GO:0036123, PomBase:mah] is_a: FYPO:0000874 ! increased histone H3-K9 dimethylation at centromere is_a: FYPO:0000886 ! abnormal histone H3-K9 dimethylation at centromere outer repeat intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0036123 ! histone H3-K9 dimethylation intersection_of: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0036123 ! histone H3-K9 dimethylation relationship: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region created_by: midori creation_date: 2012-03-20T01:25:53Z [Term] id: FYPO:0000888 name: decreased histone H3-K9 dimethylation at centromere outer repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the dimethylation of lysine at position 9 of histone H3 in centromere outer repeat regions occurs to a lower extent than normal." [PomBase:mah] synonym: "abnormal histone H3-K9 dimethylation at centromere otr" EXACT [PomBase:mah] synonym: "abnormal histone H3-K9 dimethylation at centromeric outer repeat region" EXACT [PomBase:mah] synonym: "abnormal histone H3-K9 dimethylation at pericentric region" RELATED [PomBase:mah] synonym: "abnormal histone H3-K9 dimethylation at pericentromeric region" RELATED [PomBase:mah] synonym: "decreased histone H3 K9 dimethylation at centromere outer repeat" EXACT [GO:0036123, PomBase:mah] synonym: "decreased histone H3-K9 dimethylation at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H3-K9 dimethylation at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] synonym: "decreased histone H3K9 dimethylation at centromere outer repeat" EXACT [PomBase:vw] synonym: "decreased histone H3K9me2 at centromere outer repeat" EXACT [PomBase:mah] synonym: "decreased histone lysine H3 K9 dimethylation at centromere outer repeat" EXACT [GO:0036123, PomBase:mah] synonym: "reduced histone H3-K9 dimethylation at centromere outer repeat" EXACT [PomBase:mah] is_a: FYPO:0000877 ! decreased histone H3-K9 dimethylation at centromere is_a: FYPO:0000886 ! abnormal histone H3-K9 dimethylation at centromere outer repeat is_a: FYPO:0003096 ! decreased histone H3-K9 methylation at centromere outer repeat intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0036123 ! histone H3-K9 dimethylation intersection_of: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0036123 ! histone H3-K9 dimethylation relationship: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region created_by: midori creation_date: 2012-03-20T01:36:23Z [Term] id: FYPO:0000889 name: increased histone H3-K9 trimethylation at centromere outer repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the trimethylation of lysine at position 9 of histone H3 in centromere outer repeat regions occurs to a greater extent than normal." [PomBase:mah] synonym: "abnormal histone H3-K9 trimethylation at centromere otr" EXACT [PomBase:mah] synonym: "abnormal histone H3-K9 trimethylation at centromeric outer repeat region" EXACT [PomBase:mah] synonym: "abnormal histone H3-K9 trimethylation at pericentric region" RELATED [PomBase:mah] synonym: "abnormal histone H3-K9 trimethylation at pericentromeric region" RELATED [PomBase:mah] synonym: "increased histone H3 K9 trimethylation at centromere outer repeat" EXACT [GO:0036124, PomBase:mah] synonym: "increased histone H3-K9 trimethylation at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H3-K9 trimethylation at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] synonym: "increased histone H3K9 trimethylation at centromere outer repeat" EXACT [PomBase:vw] synonym: "increased histone H3K9me3 at centromere outer repeat" EXACT [PomBase:mah] synonym: "increased histone lysine H3 K9 trimethylation at centromere outer repeat" EXACT [GO:0036124, PomBase:mah] is_a: FYPO:0000880 ! increased histone H3-K9 trimethylation at centromere is_a: FYPO:0000885 ! abnormal histone H3-K9 trimethylation at centromere outer repeat intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0036124 ! histone H3-K9 trimethylation intersection_of: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0036124 ! histone H3-K9 trimethylation relationship: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region created_by: midori creation_date: 2012-03-20T01:43:01Z [Term] id: FYPO:0000890 name: decreased histone H3-K9 trimethylation at centromere outer repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the trimethylation of lysine at position 9 of histone H3 in centromere outer repeat regions occurs to a lower extent than normal." [PomBase:mah] synonym: "abnormal histone H3-K9 trimethylation at centromere otr" EXACT [PomBase:mah] synonym: "abnormal histone H3-K9 trimethylation at centromeric outer repeat region" EXACT [PomBase:mah] synonym: "abnormal histone H3-K9 trimethylation at pericentric region" RELATED [PomBase:mah] synonym: "abnormal histone H3-K9 trimethylation at pericentromeric region" RELATED [PomBase:mah] synonym: "decreased histone H3 K9 trimethylation at centromere outer repeat" EXACT [GO:0036124, PomBase:mah] synonym: "decreased histone H3-K9 trimethylation at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H3-K9 trimethylation at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] synonym: "decreased histone H3K9 trimethylation at centromere outer repeat" EXACT [PomBase:vw] synonym: "decreased histone H3K9me3 at centromere outer repeat" EXACT [PomBase:mah] synonym: "decreased histone lysine H3 K9 trimethylation at centromere outer repeat" EXACT [GO:0036124, PomBase:mah] synonym: "reduced histone H3-K9 trimethylation at centromere outer repeat" EXACT [PomBase:mah] is_a: FYPO:0000883 ! decreased histone H3-K9 trimethylation at centromere is_a: FYPO:0000885 ! abnormal histone H3-K9 trimethylation at centromere outer repeat is_a: FYPO:0003096 ! decreased histone H3-K9 methylation at centromere outer repeat intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0036124 ! histone H3-K9 trimethylation intersection_of: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0036124 ! histone H3-K9 trimethylation relationship: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region created_by: midori creation_date: 2012-03-20T01:47:46Z [Term] id: FYPO:0000891 name: abnormal histone H3-K9 acetylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which acetylation of lysine at position 9 of histone H3 is abnormal." [PomBase:mah] synonym: "abnormal histone H3-K9 acetylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal histone H3-K9 acetylation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal histone H3K9 acetylation" EXACT [GO:0043970, PomBase:vw] is_a: FYPO:0002361 ! abnormal histone H3 acetylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0043970 ! histone H3-K9 acetylation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0043970 ! histone H3-K9 acetylation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-20T01:47:46Z [Term] id: FYPO:0000892 name: increased histone H3-K9 acetylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which acetylation of lysine at position 9 of histone H3 occurs to a greater extent than normal." [PomBase:mah] synonym: "increased histone H3-K9 acetylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H3-K9 acetylation during vegetative growth" EXACT [PomBase:mah] synonym: "increased histone H3K9 acetylation" EXACT [GO:0043970, PomBase:vw] is_a: FYPO:0002363 ! increased histone H3 acetylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0043970 ! histone H3-K9 acetylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0043970 ! histone H3-K9 acetylation created_by: midori creation_date: 2012-03-20T01:47:46Z [Term] id: FYPO:0000893 name: increased histone H3-K9 acetylation at centromere def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which acetylation of lysine at position 9 of histone H3 in centromeric regions occurs to a greater extent than normal." [PomBase:mah] synonym: "increased centromeric histone H3K9 acetylation" EXACT [GO:0043970, PomBase:mah] synonym: "increased histone H3-K9 acetylation at centromere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H3-K9 acetylation at centromere during vegetative growth" EXACT [PomBase:mah] synonym: "increased histone H3K9 acetylation at centromere" EXACT [GO:0043970, PomBase:mah] is_a: FYPO:0000892 ! increased histone H3-K9 acetylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0043970 ! histone H3-K9 acetylation intersection_of: occurs_at SO:0001795 ! regional_centromere relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0043970 ! histone H3-K9 acetylation relationship: occurs_at SO:0001795 ! regional_centromere created_by: midori creation_date: 2012-03-20T01:47:46Z [Term] id: FYPO:0000894 name: abnormal intracellular mitochondrion distribution def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which intracellular mitochondrion distribution, the process that results in the spatial arrangement of mitochondria in a cell, is abnormal." [GO:0048312, PomBase:mah] synonym: "abnormal intracellular mitochondrion distribution during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal intracellular mitochondrion distribution during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000489 ! abnormal mitochondrial distribution intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0048312 ! intracellular distribution of mitochondria intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0048312 ! intracellular distribution of mitochondria relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-29T02:42:20Z [Term] id: FYPO:0000895 name: mitochondrial aggregation def: "An abnormal intracellular mitochondrion distribution phenotype observed in the vegetative growth phase of the life cycle in which mitochondria cluster together more than normal." [PomBase:mah] synonym: "aggregated mitochondria" EXACT [PomBase:vw] synonym: "mitochondrial aggregation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "mitochondrial aggregation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000894 ! abnormal intracellular mitochondrion distribution is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: PATO:0001629 ! aggregated intersection_of: PATO:0001629 ! aggregated intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005739 ! mitochondrion relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005739 ! mitochondrion created_by: midori creation_date: 2012-03-29T02:45:02Z [Term] id: FYPO:0000896 name: mitochondrial aggregation at cell tip def: "An abnormal intracellular mitochondrion distribution phenotype observed in the vegetative growth phase of the life cycle in which mitochondria cluster together more than normal, with a cluster at one or both ends of the cell." [PomBase:mah] synonym: "aggregated mitochondria at cell tip" EXACT [PomBase:vw] synonym: "mitochondrial aggregation at cell tip during mitotic cell cycle" RELATED [PomBase:mah] synonym: "mitochondrial aggregation at cell tip during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000895 ! mitochondrial aggregation intersection_of: PATO:0001629 ! aggregated intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005739 ! mitochondrion intersection_of: occurs_at GO:0051286 ! cell tip relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005739 ! mitochondrion relationship: occurs_at GO:0051286 ! cell tip created_by: midori creation_date: 2012-03-29T02:53:52Z [Term] id: FYPO:0000897 name: normal mitochondrial fission def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitochondrial fission, the division of a mitochondrion into two or more separate compartments, is normal (i.e. indistinguishable from wild type)." [GO:0000266, PomBase:mah] synonym: "normal mitochondrial division" EXACT [GO:0000266, PomBase:mah] synonym: "normal mitochondrial fission during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal mitochondrial fission during vegetative growth" EXACT [PomBase:mah] synonym: "normal mitochondrial proliferation" RELATED [GO:0000266, PomBase:mah] is_a: FYPO:0001319 ! normal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000266 ! mitochondrial fission intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000266 ! mitochondrial fission relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-03-29T02:55:09Z [Term] id: FYPO:0000898 name: normal mitochondrial fusion def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitochondrial fusion, the merging of two or more separate mitochondria into a single compartment, is normal (i.e. indistinguishable from wild type)." [GO:0008053, PomBase:mah] synonym: "normal mitochondrial fusion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal mitochondrial fusion during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001319 ! normal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0008053 ! mitochondrial fusion intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0008053 ! mitochondrial fusion relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-03-29T02:56:39Z [Term] id: FYPO:0000899 name: normal microtubule cytoskeleton organization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which microtubule cytoskeleton organization is normal (i.e. indistinguishable from wild type). Microtubule cytoskeleton organization is the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GO:0000226, PomBase:mah] synonym: "normal microtubule cytoskeleton organisation" EXACT [PomBase:mah] synonym: "normal microtubule cytoskeleton organization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal microtubule cytoskeleton organization during vegetative growth" EXACT [PomBase:mah] synonym: "normal microtubule dynamics" EXACT [GO:0000226, PomBase:mah] synonym: "normal microtubule organization" RELATED [GO:0000226, PomBase:mah] is_a: FYPO:0001319 ! normal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000226 ! microtubule cytoskeleton organization intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000226 ! microtubule cytoskeleton organization relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-03-29T03:10:18Z [Term] id: FYPO:0000900 name: abnormal linear element assembly def: "A cellular process phenotype in which linear element assembly, the formation of a proteinaceous scaffold in association with S. pombe chromosomes during meiotic prophase, is abnormal." [PomBase:mah] synonym: "linear element formation" EXACT [GO:0030999, PomBase:mah] is_a: FYPO:0000336 ! abnormal cellular component assembly is_a: FYPO:0002739 ! abnormal meiotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0030999 ! linear element assembly intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0030999 ! linear element assembly relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-30T04:40:50Z [Term] id: FYPO:0000901 name: abnormal microtubule polymerization or depolymerization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which microtubule polymerization or depolymerization, by the addition or removal of tubulin dimers respectively, is abnormal." [GO:0031109, PomBase:mah] synonym: "abnormal microtubule polymerization or depolymerization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal microtubule polymerization or depolymerization during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001350 ! abnormal microtubule cytoskeleton organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0031109 ! microtubule polymerization or depolymerization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0031109 ! microtubule polymerization or depolymerization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-29T03:29:01Z [Term] id: FYPO:0000902 name: abnormal microtubule depolymerization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which microtubule depolymerization, i.e. the removal of tubulin dimers from a microtubule, is abnormal." [GO:0007019, PomBase:mah] synonym: "abnormal microtubule depolymerization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal microtubule depolymerization during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000901 ! abnormal microtubule polymerization or depolymerization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0007019 ! microtubule depolymerization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0007019 ! microtubule depolymerization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-29T03:30:40Z [Term] id: FYPO:0000903 name: decreased rate of microtubule depolymerization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which microtubule depolymerization, i.e. the removal of tubulin dimers from a microtubule, occurs at a lower rate, or speed, than normal." [GO:0007019, PomBase:mah] synonym: "decreased microtubule depolymerization rate" EXACT [PomBase:mah] synonym: "decreased rate of microtubule depolymerization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased rate of microtubule depolymerization during vegetative growth" EXACT [PomBase:mah] synonym: "decreased rate of microtubule shrinkage" RELATED [PomBase:vw] synonym: "increased microtubule stability" RELATED [PomBase:vw] synonym: "reduced rate of microtubule depolymerization" EXACT [PomBase:mah] is_a: FYPO:0000902 ! abnormal microtubule depolymerization is_a: PATO:0000911 ! decreased rate intersection_of: PATO:0000911 ! decreased rate intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0007019 ! microtubule depolymerization relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0007019 ! microtubule depolymerization created_by: midori creation_date: 2012-03-29T03:32:17Z [Term] id: FYPO:0000904 name: decreased microtubule polymerization or depolymerization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which microtubule polymerization or depolymerization, by the addition or removal of tubulin dimers respectively, occurs to a lesser extent than normal. Microtubules are thus less dynamic than normal." [GO:0031109, PomBase:mah] synonym: "decreased microtubule dynamicity" RELATED [PomBase:vw] synonym: "decreased microtubule polymerization or depolymerization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased microtubule polymerization or depolymerization during vegetative growth" EXACT [PomBase:mah] synonym: "reduced microtubule polymerization or depolymerization" EXACT [PomBase:mah] is_a: FYPO:0001350 ! abnormal microtubule cytoskeleton organization during vegetative growth is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0031109 ! microtubule polymerization or depolymerization relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0031109 ! microtubule polymerization or depolymerization created_by: midori creation_date: 2012-03-29T03:33:35Z [Term] id: FYPO:0000905 name: abnormal protein ubiquitination def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the ubiquitination of one or more specific proteins, or of specific protein sites, is abnormal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein ubiquitination during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein ubiquitination during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal protein ubiquitinylation" RELATED [GO:0016567, PomBase:mah] synonym: "abnormal protein ubiquitylation" EXACT [GO:0016567, PomBase:mah] is_a: FYPO:0000329 ! abnormal protein modification during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0016567 ! protein ubiquitination intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0016567 ! protein ubiquitination relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-30T04:12:43Z [Term] id: FYPO:0000906 name: abnormal mitochondrion inheritance def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitochondrion inheritance is abnormal. Mitochondrion inheritance is a cellular process that results in the distribution of mitochondria into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton." [GO:0000001, PomBase:mah] synonym: "abnormal mitochondrial inheritance" EXACT [GO:0000001, PomBase:mah] synonym: "abnormal mitochondrion inheritance during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal mitochondrion inheritance during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000489 ! abnormal mitochondrial distribution intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000001 ! mitochondrion inheritance intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000001 ! mitochondrion inheritance relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-29T03:41:35Z [Term] id: FYPO:0000907 name: abolished mitochondrion inheritance def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitochondrion inheritance is abolished, resulting in the formation of a daughter cell that lacks mitochondria." [GO:0000001, PomBase:mah] synonym: "abolished mitochondrion inheritance during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished mitochondrion inheritance during vegetative growth" EXACT [PomBase:mah] synonym: "asymmetric mitochondrial inheritance" RELATED [PomBase:vw] synonym: "mitochondrion inheritance abolished" EXACT [PomBase:mah] is_a: FYPO:0000906 ! abnormal mitochondrion inheritance is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0000001 ! mitochondrion inheritance relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0000001 ! mitochondrion inheritance created_by: midori creation_date: 2012-03-29T03:47:40Z [Term] id: FYPO:0000908 name: mixed population including viable and inviable cells def: "A mixed population phenotype in which some cells in a population are viable and others are inviable." [PomBase:mah] comment: This term was made obsolete because a "mixed population" observation would be better represented as two or more separate phenotype annotations, each with penetrance specified. is_obsolete: true created_by: midori creation_date: 2012-03-29T03:52:40Z [Term] id: FYPO:0000909 name: abnormal protein localization to linear element def: "A cell phenotype in which the localization of a protein to linear elements is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found at linear elements and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to linear element" EXACT [GO:0036181, PomBase:mah] is_a: FYPO:0002957 ! abnormal protein localization to nucleus during meiosis intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0036181 ! protein localization to linear element intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0036181 ! protein localization to linear element relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-03-30T04:48:31Z [Term] id: FYPO:0000911 name: increased nuclear RNA level during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in the cell nucleus is higher than normal. Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [PMID:12896976, PomBase:mah] comment: We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased nuclear RNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased nuclear transcript level during vegetative growth" EXACT [PomBase:vw] synonym: "increased RNA level in nucleus during vegetative growth" EXACT [PomBase:mah] synonym: "nuclear accumulation of RNA" RELATED [PomBase:mah] synonym: "nuclear RNA accumulation during vegetative growth" RELATED [PomBase:mah] is_a: FYPO:0000825 ! increased RNA level during vegetative growth is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: FYPO:0002403 ! abnormal nucleus intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005634 ! nucleus intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005634 ! nucleus relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2012-03-29T04:01:15Z [Term] id: FYPO:0000912 name: abolished protein ubiquitination def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the ubiquitination of one or more specific proteins, or of specific protein sites, does not occur." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein ubiquitination during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein ubiquitination during vegetative growth" EXACT [PomBase:mah] synonym: "abolished protein ubiquitinylation" RELATED [GO:0016567, PomBase:mah] synonym: "abolished protein ubiquitylation" EXACT [GO:0016567, PomBase:mah] synonym: "protein ubiquitination abolished" EXACT [PomBase:mah] is_a: FYPO:0000544 ! abolished protein modification during vegetative growth is_a: FYPO:0000905 ! abnormal protein ubiquitination intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0016567 ! protein ubiquitination relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0016567 ! protein ubiquitination created_by: midori creation_date: 2012-03-30T04:14:39Z [Term] id: FYPO:0000913 name: abnormal sporulation resulting in formation of ascus containing non-uniform spores def: "A sporulation phenotype that results in the formation of an ascus that contains spores of non-uniform size and DNA content." [PMID:20298435, PomBase:mah, PomBase:vw] synonym: "abnormal ascospore formation resulting in formation ascus containing non-uniform spores" EXACT [GO:0030437, PomBase:mah] synonym: "abnormal sporulation resulting in formation of asci containing non-uniform spores" RELATED [PomBase:mah] is_a: FYPO:0000121 ! abnormal sporulation created_by: midori creation_date: 2012-04-02T12:04:59Z [Term] id: FYPO:0000914 name: normal glutamate-ammonia ligase activity def: "A molecular function phenotype in which the observed rate of glutamate-ammonia ligase (also known as glutamine synthetase) activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal glutamine synthetase activity" EXACT [GO:0004356, PomBase:mah] synonym: "normal glutamylhydroxamic synthetase activity" EXACT [GO:0004356] synonym: "normal GS activity" EXACT [PMID:7851743, PomBase:al] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004356 ! glutamate-ammonia ligase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0004356 ! glutamate-ammonia ligase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-04-02T01:46:50Z [Term] id: FYPO:0000915 name: abnormal pyruvate dehydrogenase activity def: "A molecular function phenotype in which the observed rate of pyruvate dehydrogenase activity is abnormal." [PomBase:mah] synonym: "abnormal PDH activity" EXACT [PMID:7851743, PomBase:al] is_a: FYPO:0000689 ! abnormal oxidoreductase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004738 ! pyruvate dehydrogenase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004738 ! pyruvate dehydrogenase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-04-02T01:51:18Z [Term] id: FYPO:0000916 name: decreased pyruvate dehydrogenase activity def: "A molecular function phenotype in which the observed rate of pyruvate dehydrogenase activity is decreased." [PomBase:mah] synonym: "decreased PDH activity" EXACT [PMID:7851743, PomBase:al] synonym: "reduced pyruvate dehydrogenase activity" EXACT [PomBase:mah] is_a: FYPO:0000690 ! decreased oxidoreductase activity is_a: FYPO:0000915 ! abnormal pyruvate dehydrogenase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004738 ! pyruvate dehydrogenase activity relationship: inheres_in GO:0004738 ! pyruvate dehydrogenase activity created_by: midori creation_date: 2012-04-02T01:51:30Z [Term] id: FYPO:0000917 name: abnormal citrate (Si)-synthase activity def: "A molecular function phenotype in which the observed rate of citrate (Si)-synthase activity is abnormal." [PomBase:mah] synonym: "abnormal citrate synthase activity" BROAD [GO:0004108, PMID:7851743, PomBase:al] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004108 ! citrate (Si)-synthase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004108 ! citrate (Si)-synthase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-04-02T01:54:26Z [Term] id: FYPO:0000918 name: decreased citrate (Si)-synthase activity def: "A molecular function phenotype in which the observed rate of citrate (Si)-synthase activity is decreased." [PomBase:mah] synonym: "decreased citrate synthase activity" BROAD [GO:0004108, PMID:7851743, PomBase:al] synonym: "reduced citrate (Si)-synthase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0000917 ! abnormal citrate (Si)-synthase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004108 ! citrate (Si)-synthase activity relationship: inheres_in GO:0004108 ! citrate (Si)-synthase activity created_by: midori creation_date: 2012-04-02T01:54:32Z [Term] id: FYPO:0000919 name: increased citrate (Si)-synthase activity def: "A molecular function phenotype in which the observed rate of citrate (Si)-synthase activity is increased." [PomBase:mah] synonym: "increased citrate synthase activity" BROAD [GO:0004108, PMID:7851743, PomBase:al] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0000917 ! abnormal citrate (Si)-synthase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0004108 ! citrate (Si)-synthase activity relationship: inheres_in GO:0004108 ! citrate (Si)-synthase activity created_by: midori creation_date: 2012-04-02T02:24:33Z [Term] id: FYPO:0000920 name: abnormal aconitate hydratase activity def: "A molecular function phenotype in which the observed rate of aconitate hydratase (also known as aconitase) activity is abnormal." [PomBase:mah] synonym: "abnormal aconitase activity" EXACT [GO:0003994, PMID:7851743, PomBase:al] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0003994 ! aconitate hydratase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0003994 ! aconitate hydratase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-04-02T02:26:26Z [Term] id: FYPO:0000921 name: increased aconitate hydratase activity def: "A molecular function phenotype in which the observed rate of aconitate hydratase (also known as aconitase) activity is increased." [PomBase:mah] synonym: "increased aconitase activity" EXACT [GO:0003994, PMID:7851743, PomBase:al] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0000920 ! abnormal aconitate hydratase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0003994 ! aconitate hydratase activity relationship: inheres_in GO:0003994 ! aconitate hydratase activity created_by: midori creation_date: 2012-04-02T02:26:32Z [Term] id: FYPO:0000922 name: abnormal isocitrate dehydrogenase (NAD+) activity def: "A molecular function phenotype in which the observed rate of isocitrate dehydrogenase (NAD+) activity is abnormal." [PomBase:mah] synonym: "abnormal NAD-IDH activity" EXACT [PMID:7851743, PomBase:al] is_a: FYPO:0000689 ! abnormal oxidoreductase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004449 ! isocitrate dehydrogenase (NAD+) activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004449 ! isocitrate dehydrogenase (NAD+) activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-04-02T02:33:48Z [Term] id: FYPO:0000923 name: increased isocitrate dehydrogenase (NAD+) activity def: "A molecular function phenotype in which the observed rate of isocitrate dehydrogenase (NAD+) activity is increased." [PomBase:mah] synonym: "increased NAD-IDH activity" EXACT [PMID:7851743, PomBase:al] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0000922 ! abnormal isocitrate dehydrogenase (NAD+) activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0004449 ! isocitrate dehydrogenase (NAD+) activity relationship: inheres_in GO:0004449 ! isocitrate dehydrogenase (NAD+) activity created_by: midori creation_date: 2012-04-02T02:33:56Z [Term] id: FYPO:0000924 name: resistance to anisomycin def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of anisomycin than normal." [PomBase:mah] synonym: "resistance to anisomycin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to anisomycin during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to anisomycin" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:338412 ! (-)-anisomycin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:338412 ! (-)-anisomycin created_by: midori creation_date: 2012-04-02T02:43:27Z [Term] id: FYPO:0000925 name: unequal meiotic chromosome segregation def: "A cellular process phenotype in which chromosomes are not segregated equally to both spindle poles in a meiotic division." [PomBase:mah] synonym: "meiotic chromosome nondisjunction" EXACT [PomBase:mah] is_a: FYPO:0000151 ! abnormal meiotic chromosome segregation created_by: midori creation_date: 2012-04-02T03:09:45Z [Term] id: FYPO:0000926 name: normal volume vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell has a normal volume." [PomBase:mah] synonym: "normal volume cells during vegetative growth" EXACT [PomBase:mah] synonym: "normal volume vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001124 ! normal vegetative cell size is_a: PATO:0000918 ! volume intersection_of: PATO:0000918 ! volume intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-04-03T03:12:03Z [Term] id: FYPO:0000927 name: abolished horsetail movement def: "A cellular process phenotype in which horsetail movement does not occur. Horsetail movement is the oscillatory movement of the nucleus that takes place during meiotic prophase I." [GO:0030989, PomBase:mah] synonym: "absent horsetail movement" EXACT [PomBase:vw] synonym: "dynein-driven meiotic oscillatory nuclear movement abolished" EXACT [GO:0030989, PomBase:mah] synonym: "horsetail movement abolished" EXACT [PomBase:mah] synonym: "horsetail nuclear movement abolished" EXACT [GO:0030989, PomBase:mah] is_a: FYPO:0000197 ! abnormal horsetail movement is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0030989 ! dynein-driven meiotic oscillatory nuclear movement relationship: towards GO:0030989 ! dynein-driven meiotic oscillatory nuclear movement created_by: midori creation_date: 2012-04-02T03:23:19Z [Term] id: FYPO:0000928 name: abnormal protein localization to cell cortex def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the cell cortex is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found at the cell cortex and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to cell cortex" EXACT [PomBase:mah] synonym: "abnormal protein localization to cell cortex during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein localization to cell cortex during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000443 ! abnormal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0072697 ! protein localization to cell cortex intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0072697 ! protein localization to cell cortex relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-04-02T03:52:49Z [Term] id: FYPO:0000929 name: decreased protein localization to cell cortex def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the cell cortex is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to cell cortex" EXACT [PomBase:mah] synonym: "decreased protein localization to cell cortex during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to cell cortex during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to cell cortex" EXACT [PomBase:mah] is_a: FYPO:0000928 ! abnormal protein localization to cell cortex is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072697 ! protein localization to cell cortex relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072697 ! protein localization to cell cortex created_by: midori creation_date: 2012-04-02T03:52:49Z [Term] id: FYPO:0000930 name: abolished protein localization to cell cortex def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the cell cortex does not occur." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to cell cortex" EXACT [PomBase:mah] synonym: "abolished protein localization to cell cortex during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein absent from cell cortex" RELATED [PomBase:mah] synonym: "protein localization to cell cortex abolished" EXACT [PomBase:mah] synonym: "protein localization to cell cortex abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000928 ! abnormal protein localization to cell cortex is_a: FYPO:0001179 ! protein localization abolished during vegetative growth intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0072697 ! protein localization to cell cortex relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0072697 ! protein localization to cell cortex created_by: midori creation_date: 2012-04-02T03:52:49Z [Term] id: FYPO:0000931 name: abnormal protein localization to microtubule cytoskeleton during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the microtubule cytoskeleton is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found associated with the microtubule cytoskeleton and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to microtubule cytoskeleton during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal protein localization to microtubule cytoskeleton during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000443 ! abnormal protein localization during vegetative growth is_a: FYPO:0004090 ! abnormal protein localization to microtubule cytoskeleton intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0072698 ! protein localization to microtubule cytoskeleton intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0072698 ! protein localization to microtubule cytoskeleton relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-04-02T03:52:49Z [Term] id: FYPO:0000932 name: increased protein localization to microtubule cytoskeleton during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the microtubule cytoskeleton is increased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to microtubule cytoskeleton during vegetative growth" EXACT [PomBase:mah] synonym: "increased protein localization to microtubule cytoskeleton during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000931 ! abnormal protein localization to microtubule cytoskeleton during vegetative growth is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072698 ! protein localization to microtubule cytoskeleton relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072698 ! protein localization to microtubule cytoskeleton created_by: midori creation_date: 2012-04-02T03:52:49Z [Term] id: FYPO:0000933 name: decreased protein localization to microtubule cytoskeleton during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the microtubule cytoskeleton is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to microtubule cytoskeleton during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein localization to microtubule cytoskeleton during mitotic cell cycle" RELATED [PomBase:mah] synonym: "reduced protein localization to microtubule cytoskeleton during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000931 ! abnormal protein localization to microtubule cytoskeleton during vegetative growth is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072698 ! protein localization to microtubule cytoskeleton relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072698 ! protein localization to microtubule cytoskeleton created_by: midori creation_date: 2012-04-02T03:52:49Z [Term] id: FYPO:0000934 name: abolished protein localization to microtubule cytoskeleton during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the microtubule cytoskeleton does not occur." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to microtubule cytoskeleton during vegetative growth" EXACT [PomBase:mah] synonym: "abolished protein localization to microtubule cytoskeleton during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein absent from microtubule cytoskeleton during vegetative growth" RELATED [PomBase:mah] synonym: "protein localization to microtubule cytoskeleton abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000931 ! abnormal protein localization to microtubule cytoskeleton during vegetative growth is_a: FYPO:0001179 ! protein localization abolished during vegetative growth is_a: FYPO:0004091 ! abolished protein localization to microtubule cytoskeleton intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0072698 ! protein localization to microtubule cytoskeleton relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0072698 ! protein localization to microtubule cytoskeleton created_by: midori creation_date: 2012-04-02T03:52:49Z [Term] id: FYPO:0000935 name: abnormal protein localization to cortical microtubule cytoskeleton during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the cortical microtubule cytoskeleton is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found associated with the cortical microtubule cytoskeleton and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to cortical microtubule cytoskeleton during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal protein localization to cortical microtubule cytoskeleton during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000928 ! abnormal protein localization to cell cortex is_a: FYPO:0000931 ! abnormal protein localization to microtubule cytoskeleton during vegetative growth is_a: FYPO:0004265 ! abnormal protein localization to cortical microtubule cytoskeleton intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0072699 ! protein localization to cortical microtubule cytoskeleton intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0072699 ! protein localization to cortical microtubule cytoskeleton relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-04-02T03:52:49Z [Term] id: FYPO:0000936 name: increased protein localization to cortical microtubule cytoskeleton during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the cortical microtubule cytoskeleton is increased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to cortical microtubule cytoskeleton during vegetative growth" EXACT [PomBase:mah] synonym: "increased protein localization to cortical microtubule cytoskeleton during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000932 ! increased protein localization to microtubule cytoskeleton during vegetative growth is_a: FYPO:0000935 ! abnormal protein localization to cortical microtubule cytoskeleton during vegetative growth intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072699 ! protein localization to cortical microtubule cytoskeleton relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072699 ! protein localization to cortical microtubule cytoskeleton created_by: midori creation_date: 2012-04-02T03:52:49Z [Term] id: FYPO:0000937 name: decreased protein localization to cortical microtubule cytoskeleton during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the cortical microtubule cytoskeleton is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to cortical microtubule cytoskeleton during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein localization to cortical microtubule cytoskeleton during mitotic cell cycle" RELATED [PomBase:mah] synonym: "reduced protein localization to cortical microtubule cytoskeleton during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000929 ! decreased protein localization to cell cortex is_a: FYPO:0000933 ! decreased protein localization to microtubule cytoskeleton during vegetative growth is_a: FYPO:0000935 ! abnormal protein localization to cortical microtubule cytoskeleton during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072699 ! protein localization to cortical microtubule cytoskeleton relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072699 ! protein localization to cortical microtubule cytoskeleton created_by: midori creation_date: 2012-04-02T03:52:49Z [Term] id: FYPO:0000938 name: abolished protein localization to cortical microtubule cytoskeleton during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the cortical microtubule cytoskeleton does not occur." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to cortical microtubule cytoskeleton during vegetative growth" EXACT [PomBase:mah] synonym: "abolished protein localization to cortical microtubule cytoskeleton during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein absent from cortical microtubule cytoskeleton during vegetative growth" RELATED [PomBase:mah] synonym: "protein localization to cortical microtubule cytoskeleton abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000930 ! abolished protein localization to cell cortex is_a: FYPO:0000934 ! abolished protein localization to microtubule cytoskeleton during vegetative growth is_a: FYPO:0000935 ! abnormal protein localization to cortical microtubule cytoskeleton during vegetative growth is_a: FYPO:0004266 ! abolished protein localization to cortical microtubule cytoskeleton intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0072699 ! protein localization to cortical microtubule cytoskeleton relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0072699 ! protein localization to cortical microtubule cytoskeleton created_by: midori creation_date: 2012-04-02T03:52:49Z [Term] id: FYPO:0000939 name: abnormal protein localization to mitotic spindle pole body def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the mitotic spindle pole body is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found at the spindle pole body and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to mitotic spindle pole body" EXACT [PomBase:mah] synonym: "abnormal protein localization to mitotic SPB" EXACT [PomBase:mah] synonym: "abnormal protein localization to spindle pole body during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002769 ! abnormal protein localization to spindle pole body is_a: FYPO:0002824 ! abnormal protein localization to mitotic spindle intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1902440 ! protein localization to mitotic spindle pole body intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1902440 ! protein localization to mitotic spindle pole body relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-04-02T03:52:49Z [Term] id: FYPO:0000940 name: decreased protein localization to mitotic spindle pole body def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the mitotic spindle pole body is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to mitotic spindle pole body" EXACT [PomBase:mah] synonym: "decreased protein localization to mitotic SPB" EXACT [PomBase:mah] synonym: "decreased protein localization to spindle pole body during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to mitotic spindle pole body" EXACT [PomBase:mah] is_a: FYPO:0000939 ! abnormal protein localization to mitotic spindle pole body is_a: FYPO:0002770 ! decreased protein localization to spindle pole body is_a: FYPO:0002825 ! decreased protein localization to mitotic spindle intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902440 ! protein localization to mitotic spindle pole body relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902440 ! protein localization to mitotic spindle pole body created_by: midori creation_date: 2012-04-02T03:52:49Z [Term] id: FYPO:0000941 name: abolished protein localization to mitotic spindle pole body def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the mitotic spindle pole body does not occur." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "protein absent from mitotic spindle pole body" RELATED [PomBase:mah] synonym: "protein localisation to mitotic spindle pole body abolished" EXACT [PomBase:mah] synonym: "protein localization to mitotic SPB abolished" EXACT [PomBase:mah] synonym: "protein localization to mitotic spindle pole body abolished" EXACT [PomBase:mah] synonym: "protein localization to spindle pole body abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000939 ! abnormal protein localization to mitotic spindle pole body is_a: FYPO:0003186 ! abolished protein localization to mitotic spindle intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1902440 ! protein localization to mitotic spindle pole body relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1902440 ! protein localization to mitotic spindle pole body created_by: midori creation_date: 2012-04-02T03:52:49Z [Term] id: FYPO:0000942 name: abnormal nucleus localization in prospore def: "A cellular process phenotype in which nucleus localization is abnormal in a prospore." [PomBase:mah] synonym: "abnormal nuclear localization in prospore" EXACT [PomBase:mah] synonym: "abnormal nucleus localisation in prospore" EXACT [PomBase:mah] synonym: "abnormal nucleus localization in ascospore-type prospore" EXACT [GO:0005628, PomBase:mah] synonym: "abnormal nucleus localization in forespore" EXACT [PomBase:mah] is_a: FYPO:0000517 ! abnormal nucleus localization intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0051647 ! nucleus localization intersection_of: occurs_in GO:0042764 ! ascospore-type prospore intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0051647 ! nucleus localization relationship: occurs_in GO:0042764 ! ascospore-type prospore relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-04-02T04:22:13Z [Term] id: FYPO:0000943 name: normal spore morphology def: "A cell phenotype characterized by normal spore morphology, i.e. the size, shape, and structure of the spore are normal." [PomBase:mah] is_a: FYPO:0000672 ! normal cell morphology intersection_of: PATO:0000051 ! morphology intersection_of: inheres_in CL:0000596 ! sexual spore intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in CL:0000596 ! sexual spore relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-04-03T02:27:00Z [Term] id: FYPO:0000944 name: inviable spore with normal morphology def: "A viability phenotype in which a spore is unable to survive under conditions in which wild type spores survive, and has a normal morphology (i.e. size, shape, or structure). An inviable spore does not germinate." [PomBase:mah] synonym: "spore germination abolished, normal spore morphology" RELATED [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: has_part FYPO:0000943 ! normal spore morphology intersection_of: has_part FYPO:0002151 ! inviable spore relationship: has_part FYPO:0000943 ! normal spore morphology relationship: has_part FYPO:0002151 ! inviable spore created_by: midori creation_date: 2012-04-03T02:28:22Z [Term] id: FYPO:0000945 name: swollen spheroid vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is shaped in the form of a spheroid, and has a larger volume than normal. In a swollen cell, both length and diameter are greater than normal, although the cell is only considered elongated if the length:width ratio is also greater than normal." [PomBase:mah] synonym: "enlarged spheroid vegetative cell" RELATED [PomBase:mah] synonym: "enlarged volume spheroid vegetative cell" EXACT [PomBase:mah] synonym: "large spheroid vegetative cell" RELATED [PomBase:vw] synonym: "spheroid vegetative cell with increased cell size" RELATED [PomBase:vw] synonym: "spheroid vegetative cell with increased cell volume" EXACT [PomBase:mah] synonym: "swollen rounded vegetative cell" EXACT [PomBase:mah] synonym: "swollen spheroid cell during vegetative growth" EXACT [PomBase:mah] synonym: "swollen spheroid vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0002941 ! swollen spheroid cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000021 ! spheroid vegetative cell intersection_of: has_part FYPO:0000025 ! swollen cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000021 ! spheroid vegetative cell relationship: has_part FYPO:0000025 ! swollen cell created_by: midori creation_date: 2012-04-03T03:14:05Z [Term] id: FYPO:0000946 name: normal volume spheroid vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is shaped in the form of a spheroid, and has a normal volume." [PomBase:mah] synonym: "normal volume rounded vegetative cell" EXACT [PomBase:mah] synonym: "normal volume spheroid cell during vegetative growth" EXACT [PomBase:mah] synonym: "normal volume spheroid vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001121 ! vegetative cell, abnormal cell shape, normal cell size intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000021 ! spheroid vegetative cell intersection_of: has_part FYPO:0000926 ! normal volume vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000021 ! spheroid vegetative cell relationship: has_part FYPO:0000926 ! normal volume vegetative cell created_by: midori creation_date: 2012-04-03T03:16:37Z [Term] id: FYPO:0000947 name: swollen spherical vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is shaped in the form of a sphere, and has a larger volume than normal. In a swollen cell, both length and diameter are greater than normal, although the cell is only considered elongated if the length:width ratio is also greater than normal." [PomBase:mah] synonym: "enlarged spherical vegetative cell" RELATED [PomBase:mah] synonym: "enlarged volume spherical vegetative cell" EXACT [PomBase:mah] synonym: "large spherical vegetative cell" RELATED [PomBase:vw] synonym: "spherical vegetative cell with increased cell size" RELATED [PomBase:vw] synonym: "spherical vegetative cell with increased cell volume" EXACT [PomBase:mah] synonym: "swollen orb during vegetative growth" EXACT [PomBase:vw] synonym: "swollen spherical cell during vegetative growth" EXACT [PomBase:mah] synonym: "swollen spherical vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000945 ! swollen spheroid vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000025 ! swollen cell intersection_of: has_part FYPO:0000129 ! spherical vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000025 ! swollen cell relationship: has_part FYPO:0000129 ! spherical vegetative cell created_by: midori creation_date: 2012-04-03T03:27:05Z [Term] id: FYPO:0000948 name: normal volume spherical vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is shaped in the form of a sphere, and has a normal volume." [PomBase:mah] synonym: "normal volume orb during vegetative growth" EXACT [PomBase:vw] synonym: "normal volume spherical cell during vegetative growth" EXACT [PomBase:mah] synonym: "normal volume spherical vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000946 ! normal volume spheroid vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000129 ! spherical vegetative cell intersection_of: has_part FYPO:0000926 ! normal volume vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000129 ! spherical vegetative cell relationship: has_part FYPO:0000926 ! normal volume vegetative cell created_by: midori creation_date: 2012-04-03T03:28:08Z [Term] id: FYPO:0000949 name: aseptate def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which a cell does not contain a septum." [PomBase:mah] synonym: "absent septum" EXACT [PomBase:mah] synonym: "aseptate during mitotic cell cycle" RELATED [PomBase:mah] synonym: "aseptate during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0004639 ! abnormal cellular physical quality phenotype during vegetative growth is_a: PATO:0002000 ! lacks all parts of type intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards GO:0000935 ! barrier septum relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: output_of FYPO:0000272 ! abolished septum formation relationship: towards GO:0000935 ! barrier septum created_by: midori creation_date: 2012-04-03T03:38:09Z [Term] id: FYPO:0000950 name: elongated aseptate cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell does not contain a septum and is elongated." [PomBase:mah] synonym: "elongated aseptate cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "elongated aseptate cell during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000949 ! aseptate relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000949 ! aseptate created_by: midori creation_date: 2012-04-03T03:41:12Z [Term] id: FYPO:0000951 name: inviable small vegetative cell def: "A cell morphology in which a vegetative cell is inviable and has an abnormally low volume." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "essential; small vegetative cell" RELATED [PomBase:mah] synonym: "inviable small vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "small inviable cell during vegetative growth" EXACT [PomBase:mah] synonym: "small inviable vegetative cell" EXACT [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000023 ! small cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000023 ! small cell relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2012-04-03T04:12:31Z [Term] id: FYPO:0000952 name: vacuoles present in greater numbers during vegetative growth def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells contain more vacuoles than normal." [PomBase:mah] synonym: "additional vacuoles present during vegetative growth" EXACT [PomBase:mah] synonym: "extra vacuoles during vegetative growth" EXACT [PomBase:mah] synonym: "vacuoles present in greater numbers during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0002790 ! vacuoles present in greater numbers is_a: FYPO:0004639 ! abnormal cellular physical quality phenotype during vegetative growth intersection_of: PATO:0002002 ! has extra parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0000324 ! fungal-type vacuole relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0000324 ! fungal-type vacuole created_by: midori creation_date: 2012-04-03T04:18:23Z [Term] id: FYPO:0000953 name: normal cellular response to chemical stimulus def: "A cellular response phenotype in which the cellular response to a chemical stimulus is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate is_a: FYPO:0000627 ! normal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0070887 ! cellular response to chemical stimulus intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0070887 ! cellular response to chemical stimulus relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-04-12T12:15:57Z [Term] id: FYPO:0000954 name: normal growth on nickel cation def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing nickel cations." [PomBase:mah] synonym: "normal cell population growth in presence of nickel cations" EXACT [PomBase:mah] synonym: "normal cell population growth on nickel" EXACT [GO:0071289, PomBase:mah] synonym: "normal cell population growth on nickel cation" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to nickel cation" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on nickel cation" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:25516 ! nickel cation relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:25516 ! nickel cation created_by: midori creation_date: 2012-04-12T12:18:01Z [Term] id: FYPO:0000955 name: normal growth on lead ion def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing lead ions." [PomBase:mah] synonym: "normal cell population growth in presence of lead ion" EXACT [PomBase:mah] synonym: "normal cell population growth on lead ion" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to lead ion" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on lead ion" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:60252 ! lead cation relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:60252 ! lead cation created_by: midori creation_date: 2012-04-12T12:21:54Z [Term] id: FYPO:0000956 name: normal growth on bismuth def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing bismuth ions." [PomBase:mah] synonym: "normal cell population growth in presence of bismuth" EXACT [PomBase:mah] synonym: "normal cell population growth on bismuth" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to bismuth" RELATED [PomBase:al, PomBase:mah] synonym: "normal growth on bismuth ions" EXACT [PomBase:mah] synonym: "normal vegetative cell population growth on bismuth" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:85543 relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:85543 created_by: midori creation_date: 2012-04-12T12:22:52Z [Term] id: FYPO:0000957 name: normal growth on methyl methanesulfonate def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing methyl methanesulfonate." [PomBase:mah] synonym: "normal cell population growth in presence of methyl methanesulfonate" EXACT [PomBase:mah] synonym: "normal cell population growth on methyl methanesulfonate" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cell population growth on MMS" EXACT [CHEBI:25255] synonym: "normal cellular response to methyl methanesulfonate" RELATED [PomBase:al, PomBase:mah] synonym: "normal growth on methyl methanesulphonate" EXACT [PomBase:mah] synonym: "normal vegetative cell population growth on methyl methanesulfonate" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:25255 ! methyl methanesulfonate relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:25255 ! methyl methanesulfonate created_by: midori creation_date: 2012-04-12T12:23:26Z [Term] id: FYPO:0000958 name: normal growth on mercaptoethanol def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing mercaptoethanol." [PomBase:mah] synonym: "normal cell population growth in presence of mercaptoethanol" EXACT [PomBase:mah] synonym: "normal cell population growth on 2-sulfanylethanol" EXACT [CHEBI:41218] synonym: "normal cell population growth on mercaptoethanol" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to mercaptoethanol" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on mercaptoethanol" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:41218 ! mercaptoethanol relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:41218 ! mercaptoethanol created_by: midori creation_date: 2012-04-12T12:25:12Z [Term] id: FYPO:0000959 name: normal growth on sodium dodecyl sulfate def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing sodium dodecyl sulfate (SDS." [PomBase:mah] synonym: "normal cell population growth in presence of sodium dodecyl sulfate" EXACT [PomBase:mah] synonym: "normal cell population growth on SDS" EXACT [CHEBI:8984] synonym: "normal cell population growth on sodium dodecyl sulfate" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to sodium dodecyl sulfate" RELATED [PomBase:al, PomBase:mah] synonym: "normal growth on sodium dodecyl sulphate" EXACT [PomBase:mah] synonym: "normal vegetative cell population growth on sodium dodecyl sulfate" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:8984 ! sodium dodecyl sulfate relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:8984 ! sodium dodecyl sulfate created_by: midori creation_date: 2012-04-12T12:28:02Z [Term] id: FYPO:0000960 name: normal growth on ethanol def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing ethanol." [PomBase:mah] synonym: "normal cell population growth in presence of ethanol" EXACT [PomBase:mah] synonym: "normal cell population growth on ethanol" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cell population growth on to ethyl alcohol" EXACT [PomBase:mah] synonym: "normal cellular response to ethanol" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on ethanol" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:16236 ! ethanol relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:16236 ! ethanol created_by: midori creation_date: 2012-04-12T12:35:28Z [Term] id: FYPO:0000961 name: normal growth on sorbitol def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing sorbitol." [PomBase:mah] synonym: "normal cell population growth in presence of sorbitol" EXACT [PomBase:mah] synonym: "normal cell population growth on glucitol" EXACT [CHEBI:30199] synonym: "normal cell population growth on sorbitol" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to sorbitol" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on sorbitol" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:30199 ! trioxidosilicate(.1-) relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:30199 ! trioxidosilicate(.1-) created_by: midori creation_date: 2012-04-12T12:36:31Z [Term] id: FYPO:0000962 name: normal growth on hydrogen peroxide def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing hydrogen peroxide." [PomBase:mah] synonym: "normal cell population growth in presence of hydrogen peroxide" EXACT [PomBase:mah] synonym: "normal cell population growth on H2O2" EXACT [CHEBI:16240] synonym: "normal cell population growth on hydrogen peroxide" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to hydrogen peroxide" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on hydrogen peroxide" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:16240 ! hydrogen peroxide relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:16240 ! hydrogen peroxide created_by: midori creation_date: 2012-04-12T12:37:24Z [Term] id: FYPO:0000963 name: normal growth on hydroxyurea def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing hydroxyurea." [PomBase:mah] synonym: "normal cell population growth in presence of hydroxyurea" EXACT [PomBase:mah] synonym: "normal cell population growth on HU" EXACT [PomBase:mah] synonym: "normal cell population growth on hydroxyurea" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal vegetative cell population growth on hydroxyurea" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:44423 ! hydroxyurea relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:44423 ! hydroxyurea created_by: midori creation_date: 2012-04-12T12:38:22Z [Term] id: FYPO:0000964 name: normal growth on thiabendazole def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing thiabendazole." [PomBase:mah] synonym: "normal cell population growth in presence of thiabendazole" EXACT [PomBase:mah] synonym: "normal cell population growth on TBZ" EXACT [CHEBI:45979] synonym: "normal cell population growth on thiabendazole" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to thiabendazole" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on thiabendazole" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:45979 ! thiabendazole relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:45979 ! thiabendazole created_by: midori creation_date: 2012-04-12T12:39:39Z [Term] id: FYPO:0000965 name: abnormal histone H3-K14 acetylation at centromere outer repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which acetylation of lysine at position 14 of histone H3 in centromere outer repeat regions is abnormal." [PomBase:mah] synonym: "abnormal histone H3-K14 acetylation at centromere otr" EXACT [PomBase:mah] synonym: "abnormal histone H3-K14 acetylation at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal histone H3-K14 acetylation at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal histone H3-K14 acetylation at centromeric outer repeat region" EXACT [PomBase:mah] synonym: "abnormal histone H3-K14 acetylation at pericentric region" RELATED [PomBase:mah] synonym: "abnormal histone H3-K14 acetylation at pericentromeric region" RELATED [PomBase:mah] synonym: "abnormal histone H3K14 acetylation at centromere outer repeat" EXACT [GO:0044154, PomBase:vw] is_a: FYPO:0000788 ! abnormal histone H3-K14 acetylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0044154 ! histone H3-K14 acetylation intersection_of: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0044154 ! histone H3-K14 acetylation relationship: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-04-12T12:56:33Z [Term] id: FYPO:0000966 name: increased histone H3-K14 acetylation at centromere outer repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which acetylation of lysine at position 14 of histone H3 in centromere outer repeat regions occurs to a greater extent than normal." [PomBase:mah] synonym: "abnormal histone H3-K14 acetylation at centromere otr" EXACT [PomBase:mah] synonym: "abnormal histone H3-K14 acetylation at centromeric outer repeat region" EXACT [PomBase:mah] synonym: "abnormal histone H3-K14 acetylation at pericentric region" RELATED [PomBase:mah] synonym: "abnormal histone H3-K14 acetylation at pericentromeric region" RELATED [PomBase:mah] synonym: "increased histone H3-K14 acetylation at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H3-K14 acetylation at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] synonym: "increased histone H3K14 acetylation at centromere outer repeat" EXACT [GO:0044154, PomBase:vw] is_a: FYPO:0000965 ! abnormal histone H3-K14 acetylation at centromere outer repeat is_a: FYPO:0002381 ! increased histone H3 acetylation at centromere outer repeat intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0044154 ! histone H3-K14 acetylation intersection_of: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0044154 ! histone H3-K14 acetylation relationship: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region created_by: midori creation_date: 2012-04-12T02:31:26Z [Term] id: FYPO:0000967 name: decreased histone H3-K14 acetylation at centromere outer repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which acetylation of lysine at position 14 of histone H3 in centromere outer repeat regions occurs to a lower extent than normal." [PomBase:mah] synonym: "abnormal histone H3-K14 acetylation at centromere otr" EXACT [PomBase:mah] synonym: "abnormal histone H3-K14 acetylation at centromeric outer repeat region" EXACT [PomBase:mah] synonym: "abnormal histone H3-K14 acetylation at pericentric region" RELATED [PomBase:mah] synonym: "abnormal histone H3-K14 acetylation at pericentromeric region" RELATED [PomBase:mah] synonym: "decreased histone H3-K14 acetylation at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H3-K14 acetylation at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] synonym: "decreased histone H3K14 acetylation at centromere outer repeat" EXACT [GO:0044154, PomBase:vw] synonym: "reduced histone H3-K14 acetylation at centromere outer repeat" EXACT [PomBase:mah] is_a: FYPO:0000965 ! abnormal histone H3-K14 acetylation at centromere outer repeat is_a: FYPO:0001458 ! decreased histone H3-K14 acetylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0044154 ! histone H3-K14 acetylation intersection_of: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0044154 ! histone H3-K14 acetylation relationship: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region created_by: midori creation_date: 2012-04-12T02:32:04Z [Term] id: FYPO:0000968 name: normal cellular response to stress def: "A cellular response phenotype observed in the vegetative growth phase of the life cycle in which the cellular response to a stress is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular response to stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular response to stress during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001319 ! normal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0033554 ! cellular response to stress intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0033554 ! cellular response to stress relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-04-19T01:25:21Z [Term] id: FYPO:0000969 name: normal growth during cellular response to UV def: "A cell growth phenotype in which cell population growth is normal (i.e. indistinguishable from wild type) during a cellular response to ultraviolet light." [PomBase:mah] synonym: "normal cell population growth during cellular response to ultraviolet light" EXACT [PomBase:mah] synonym: "normal cell population growth during cellular response to UV" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to UV" RELATED [PomBase:mah] synonym: "normal sensitivity to UV irradiation" RELATED [PomBase:vw] synonym: "normal vegetative cell population growth during cellular response to UV" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: happens_during GO:0034644 ! cellular response to UV relationship: happens_during GO:0034644 ! cellular response to UV created_by: midori creation_date: 2012-04-19T01:25:40Z [Term] id: FYPO:0000970 name: sensitive to mitomycin C def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to mitomycin C. Cells stop growing (and may die) at a concentration of mitomycin C that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to mitomycin C" EXACT [PomBase:mah] synonym: "sensitive to mitomycin C during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to mitomycin C during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:27504 ! mitomycin C relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:27504 ! mitomycin C created_by: midori creation_date: 2012-04-19T01:38:22Z [Term] id: FYPO:0000972 name: increased number of Rad52 foci during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the number of sites at which the protein Rad52 (also called Rad22) accumulates is greater than normal." [PMID:22064477, PomBase:mah] comment: Because Rad22 often accumulates at double-strand breaks, consider also annotating to 'accumulation of double-strand break sites' (FYPO:0000455). synonym: "increased number of Rad22 foci during vegetative growth" EXACT [PomBase:mah] synonym: "increased number of Rad52 foci during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001321 ! cellular physical quality phenotype during vegetative growth is_a: FYPO:0004709 ! increased number of Rad52 foci created_by: midori creation_date: 2012-04-19T02:09:54Z [Term] id: FYPO:0000973 name: normal cellular response to copper ion def: "A cellular response phenotype observed in the vegetative growth phase of the life cycle in which the cellular response to copper ions is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular response to copper" EXACT [GO:0071280] synonym: "normal cellular response to copper ion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular response to copper ion during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001318 ! normal cellular response to chemical stimulus during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071280 ! cellular response to copper ion intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071280 ! cellular response to copper ion relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-04-19T02:30:26Z [Term] id: FYPO:0000974 name: normal cellular response to zinc ion def: "A cellular response phenotype observed in the vegetative growth phase of the life cycle in which the cellular response to zinc ions is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular response to zinc" EXACT [GO:0071294] synonym: "normal cellular response to zinc ion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular response to zinc ion during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001318 ! normal cellular response to chemical stimulus during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071294 ! cellular response to zinc ion intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071294 ! cellular response to zinc ion relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-04-19T02:31:30Z [Term] id: FYPO:0000975 name: normal cellular response to mercury ion def: "A cellular response phenotype observed in the vegetative growth phase of the life cycle in which the cellular response to mercury ions is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular response to mercury" EXACT [GO:0071248] synonym: "normal cellular response to mercury ion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular response to mercury ion during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001318 ! normal cellular response to chemical stimulus during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071288 ! cellular response to mercury ion intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071288 ! cellular response to mercury ion relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-04-19T02:32:52Z [Term] id: FYPO:0000976 name: normal cellular response to selenite ion def: "A cellular response phenotype observed in the vegetative growth phase of the life cycle in which the cellular response to selenite ions is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular response to selenite" EXACT [PomBase:mah] synonym: "normal cellular response to selenite ion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular response to selenite ion during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001318 ! normal cellular response to chemical stimulus during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072715 ! cellular response to selenite ion intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072715 ! cellular response to selenite ion relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-04-19T02:33:28Z [Term] id: FYPO:0000977 name: normal cellular response to silver ion def: "A cellular response phenotype observed in the vegetative growth phase of the life cycle in which the cellular response to silver ions is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular response to silver ion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular response to silver ion during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001318 ! normal cellular response to chemical stimulus during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071292 ! cellular response to silver ion intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071292 ! cellular response to silver ion relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-04-19T02:34:05Z [Term] id: FYPO:0000978 name: normal growth on mevastatin def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing mevastatin." [PomBase:mah] synonym: "normal cell population growth on compactin" EXACT [PomBase:al] synonym: "normal cell population growth on mevastatin" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal vegetative cell population growth on mevastatin" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0000047 ! normal cell population growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:34848 ! mevastatin relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:34848 ! mevastatin created_by: midori creation_date: 2012-04-19T04:43:12Z [Term] id: FYPO:0000979 name: normal growth on miconazole def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing miconazole." [PomBase:mah] synonym: "normal cell population growth on miconazole" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal vegetative cell population growth on miconazole" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0000047 ! normal cell population growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:6923 ! miconazole relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:6923 ! miconazole created_by: midori creation_date: 2012-04-19T04:45:21Z [Term] id: FYPO:0000980 name: normal growth on amphotericin B def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing amphotericin B." [PomBase:mah] synonym: "normal cell population growth on amphotericin B" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal vegetative cell population growth on amphotericin B" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0000047 ! normal cell population growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:2682 ! amphotericin B relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:2682 ! amphotericin B created_by: midori creation_date: 2012-04-19T04:46:40Z [Term] id: FYPO:0000981 name: normal glutamate dehydrogenase (NAD+) activity def: "A molecular function phenotype in which the observed rate of glutamate dehydrogenase activity using NAD+ as a cofactor is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal NAD-GDH activity" EXACT [PMID:7851743, PomBase:al] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004352 ! glutamate dehydrogenase (NAD+) activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0004352 ! glutamate dehydrogenase (NAD+) activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-04-20T02:09:01Z [Term] id: FYPO:0000982 name: abnormal glutamate dehydrogenase (NADP+) activity def: "A molecular function phenotype in which the observed rate of glutamate dehydrogenase activity using NAPD+ as a cofactor is abnormal." [PomBase:mah] synonym: "abnormal NADP-GDH activity" EXACT [PMID:7851743, PomBase:al] is_a: FYPO:0000689 ! abnormal oxidoreductase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004354 ! glutamate dehydrogenase (NADP+) activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004354 ! glutamate dehydrogenase (NADP+) activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-04-20T02:12:39Z [Term] id: FYPO:0000983 name: decreased glutamate dehydrogenase (NADP+) activity def: "A molecular function phenotype in which the observed rate of glutamate dehydrogenase activity using NAPD+ as a cofactor is decreased." [PomBase:mah] synonym: "decreased NADP-GDH activity" EXACT [PMID:7851743, PomBase:al] synonym: "reduced glutamate dehydrogenase (NADP+) activity" EXACT [PomBase:mah] is_a: FYPO:0000690 ! decreased oxidoreductase activity is_a: FYPO:0000982 ! abnormal glutamate dehydrogenase (NADP+) activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004354 ! glutamate dehydrogenase (NADP+) activity relationship: inheres_in GO:0004354 ! glutamate dehydrogenase (NADP+) activity created_by: midori creation_date: 2012-04-20T02:12:45Z [Term] id: FYPO:0000984 name: abnormal transcriptional response to pheromone def: "A conjugation phenotype in which regulation of transcription in response to mating pheromone is abnormal." [PomBase:mah] synonym: "abnormal regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [GO:0046019, PomBase:mah] is_a: FYPO:0000143 ! transcription regulation phenotype is_a: FYPO:0000302 ! abnormal response to pheromone intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0046019 ! regulation of transcription from RNA polymerase II promoter by pheromones intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0046019 ! regulation of transcription from RNA polymerase II promoter by pheromones relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-04-25T12:26:50Z [Term] id: FYPO:0000985 name: transcriptional response to pheromone at increased pheromone level def: "A cellular response phenotype in which pheromone-responsive positive regulation of transcription from an RNA polymerase II promoter occurs only at a higher level of pheromone than normal." [PomBase:mah] comment: This term was made obsolete because it has a confusing name and represents a non-useful distinction. synonym: "decreased sensitivity of positive regulation of transcription from RNA polymerase II promoter by pheromones to pheromone" RELATED [PomBase:mah] synonym: "decreased transcriptional response to pheromone" RELATED [PomBase:mah] synonym: "positive regulation of transcription from RNA polymerase II promoter by pheromones at increased pheromone level" EXACT [GO:0007329, PomBase:mah] synonym: "resistant to pheromone" RELATED [PomBase:al, PomBase:mah] is_obsolete: true created_by: midori creation_date: 2012-04-25T12:29:45Z [Term] id: FYPO:0000986 name: increased transcriptional response to pheromone at normal pheromone level def: "A cellular response phenotype in which pheromone-responsive positive regulation of transcription from an RNA polymerase II promoter results in a higher-than-normal level of transcription at a given pheromone level." [PomBase:mah] comment: This term was made obsolete because it has a confusing name and represents a non-useful distinction. synonym: "increased positive regulation of transcription from RNA polymerase II promoter by pheromones at normal pheromone level" EXACT [GO:0007329, PomBase:mah] synonym: "increased sensitivity of positive regulation of transcription from RNA polymerase II promoter by pheromones to pheromone" RELATED [PomBase:mah] synonym: "increased transcriptional response to pheromone" RELATED [PomBase:mah] synonym: "sensitive to pheromone" RELATED [PomBase:al, PomBase:mah] is_obsolete: true created_by: midori creation_date: 2012-04-25T12:34:59Z [Term] id: FYPO:0000987 name: decreased transcriptional response to pheromone at normal pheromone level def: "A cellular response phenotype in which pheromone-responsive positive regulation of transcription from an RNA polymerase II promoter results in a lower-than-normal level of transcription at a given pheromone level." [PomBase:mah] comment: This term was made obsolete because it has a confusing name and represents a non-useful distinction. synonym: "decreased positive regulation of transcription from RNA polymerase II promoter by pheromones at normal pheromone level" EXACT [GO:0007329, PomBase:mah] synonym: "decreased sensitivity of positive regulation of transcription from RNA polymerase II promoter by pheromones to pheromone" RELATED [PomBase:mah] synonym: "decreased transcriptional response to pheromone" RELATED [PomBase:mah] synonym: "reduced transcriptional response to pheromone at normal pheromone level" EXACT [PomBase:mah] synonym: "resistant to pheromone" RELATED [PomBase:al, PomBase:mah] is_obsolete: true created_by: midori creation_date: 2012-04-25T12:49:41Z [Term] id: FYPO:0000988 name: normal cellular response to arsenic def: "A cellular response phenotype observed in the vegetative growth phase of the life cycle in which the cellular response to arsenic is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular response to arsenic during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular response to arsenic during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001318 ! normal cellular response to chemical stimulus during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071243 ! cellular response to arsenic-containing substance intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071243 ! cellular response to arsenic-containing substance relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-04-25T01:27:55Z [Term] id: FYPO:0000989 name: altered level of substance in cell def: "A cell phenotype in which the amount of a specific substance measured in a cell differs from normal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "abnormal level of substance in cell" EXACT [PomBase:mah] is_a: FYPO:0003037 ! abnormal cell phenotype is_a: FYPO:0004638 ! abnormal cellular physical quality phenotype is_a: PATO:0001159 ! concentrated intersection_of: PATO:0001159 ! concentrated intersection_of: inheres_in CL:0000000 ! cell intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:24431 ! chemical entity relationship: inheres_in CL:0000000 ! cell relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:24431 ! chemical entity created_by: midori creation_date: 2012-04-25T02:06:49Z [Term] id: FYPO:0000990 name: increased level of substance in cell def: "A cell phenotype in which the amount of a specific substance measured in a cell is higher than normal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "increased accumulation of substance in cell" RELATED [PomBase:mah] is_a: FYPO:0000989 ! altered level of substance in cell is_a: PATO:0001162 ! increased concentration intersection_of: PATO:0001162 ! increased concentration intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:24431 ! chemical entity relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:24431 ! chemical entity created_by: midori creation_date: 2012-04-25T02:07:28Z [Term] id: FYPO:0000991 name: decreased level of substance in cell def: "A cell phenotype in which the amount of a specific substance measured in a cell is lower than normal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "reduced level of substance in cell" EXACT [PomBase:mah] is_a: FYPO:0000989 ! altered level of substance in cell is_a: PATO:0001163 ! decreased concentration intersection_of: PATO:0001163 ! decreased concentration intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:24431 ! chemical entity relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:24431 ! chemical entity created_by: midori creation_date: 2012-04-25T02:08:00Z [Term] id: FYPO:0000992 name: altered cellular phosphatidylinositol-3-phosphate level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of phosphatidylinositol-3-phosphate measured in a cell differs from normal." [PomBase:mah] synonym: "abnormal cellular phosphatidylinositol-3-phosphate level" EXACT [PomBase:mah] synonym: "altered cellular phosphatidylinositol-3-phosphate level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "altered cellular phosphatidylinositol-3-phosphate level during vegetative growth" EXACT [PomBase:mah] synonym: "altered cellular PI-3-P level" EXACT [PomBase:al] synonym: "altered PI-3-P accumulation" RELATED [PomBase:al] is_a: FYPO:0001290 ! altered cellular phosphoinositide level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:26034 ! phosphatidylinositol 3-phosphate relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:26034 ! phosphatidylinositol 3-phosphate created_by: midori creation_date: 2012-04-25T02:15:24Z [Term] id: FYPO:0000993 name: decreased cellular phosphatidylinositol-3-phosphate level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of phosphatidylinositol-3-phosphate measured in a cell is lower than normal." [PomBase:mah] synonym: "decreased cellular phosphatidylinositol-3-phosphate level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular phosphatidylinositol-3-phosphate level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased cellular PI-3-P level" EXACT [PomBase:al] synonym: "decreased PI-3-P accumulation" RELATED [PomBase:al] synonym: "reduced cellular phosphatidylinositol-3-phosphate level" EXACT [PomBase:mah] is_a: FYPO:0000992 ! altered cellular phosphatidylinositol-3-phosphate level is_a: FYPO:0001289 ! decreased phospholipid level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:26034 ! phosphatidylinositol 3-phosphate relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:26034 ! phosphatidylinositol 3-phosphate created_by: midori creation_date: 2012-04-25T02:18:12Z [Term] id: FYPO:0000994 name: increased cellular phosphatidylinositol-4-phosphate level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of phosphatidylinositol-4-phosphate measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular phosphatidylinositol-4-phosphate level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular phosphatidylinositol-4-phosphate level during vegetative growth" EXACT [PomBase:mah] synonym: "increased cellular PI-4-P level" EXACT [PomBase:al] synonym: "increased PI-4-P accumulation" RELATED [PomBase:al] is_a: FYPO:0001015 ! altered cellular phosphatidylinositol-4-phosphate level is_a: FYPO:0001286 ! increased cellular phosphoinositide level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:37530 ! phosphatidylinositol 4-phosphate relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:37530 ! phosphatidylinositol 4-phosphate created_by: midori creation_date: 2012-04-25T02:19:52Z [Term] id: FYPO:0000995 name: abnormal cell morphology during nitrogen starvation def: "A cell phenotype in which cell morphology (i.e. the size, shape, or structure of the cell) is altered when the cell is subject to nitrogen starvation." [PMID:19366728, PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "abnormal cell morphology during nitrogen depletion" EXACT [PomBase:vw] synonym: "abnormal cell morphology during nitrogen deprivation" EXACT [PomBase:vw] is_a: FYPO:0000005 ! abnormal cell morphology intersection_of: FYPO:0000005 ! abnormal cell morphology intersection_of: exists_during GO:0006995 ! cellular response to nitrogen starvation relationship: exists_during GO:0006995 ! cellular response to nitrogen starvation created_by: midori creation_date: 2012-04-25T02:40:49Z [Term] id: FYPO:0000996 name: tapered cell during nitrogen starvation def: "A cell morphology phenotype in which the cell tapers at one end to a diameter smaller than the other when the cell is subject to nitrogen starvation. The cell diameter at the narrow end is smaller than that of a wild-type cell." [PMID:19366728, PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "bottle-shaped cell during nitrogen starvation" EXACT [PomBase:vw] synonym: "cell morphology, bottle/skittle during nitrogen starvation" EXACT [PomBase:mah] synonym: "skittle-shaped cell during nitrogen starvation" EXACT [PomBase:mah] synonym: "tapered cell during nitrogen depletion" EXACT [PomBase:vw] synonym: "tapered cell during nitrogen deprivation" EXACT [PomBase:vw] is_a: FYPO:0000014 ! tapered cell is_a: FYPO:0000995 ! abnormal cell morphology during nitrogen starvation intersection_of: PATO:0002213 ! obclavate intersection_of: exists_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in CL:0000000 ! cell relationship: exists_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in CL:0000000 ! cell created_by: midori creation_date: 2012-04-25T02:41:14Z [Term] id: FYPO:0000997 name: pear-shaped cell during nitrogen starvation def: "A cell morphology phenotype in which a cell is shaped in the form of a pear when the cell is subject to nitrogen starvation. One end is rounded, while the other resembles an end of a normal rod-shaped cell. The normally shaped end has the same diameter as a wild-type cell." [PMID:19366728, PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "cell morphology, pear shaped during nitrogen starvation" EXACT [PomBase:mah] synonym: "ice cream cone-shaped cell during nitrogen starvation" EXACT [PMID:2236039, PomBase:vw] synonym: "pear-shaped cell during nitrogen depletion" EXACT [PomBase:vw] synonym: "pear-shaped cell during nitrogen deprivation" EXACT [PomBase:vw] is_a: FYPO:0000020 ! pear-shaped cell is_a: FYPO:0000995 ! abnormal cell morphology during nitrogen starvation intersection_of: PATO:0002240 ! teardrop-shaped intersection_of: exists_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in CL:0000000 ! cell relationship: exists_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in CL:0000000 ! cell created_by: midori creation_date: 2012-04-25T02:41:20Z [Term] id: FYPO:0000998 name: elongated cell during nitrogen starvation def: "A cell morphology phenotype in which a cell becomes longer than normal, i.e. the maximum distance between the cell ends is greater than normal, when the cell is subject to nitrogen starvation." [PMID:19366728, PomBase:mah] comment: Note that wild-type cells become shorter under nitrogen starvation conditions than under nitrogen-replete conditions, and that mutant cells subjected to nitrogen starvation may have lengths similar to wild type cells under non-starved conditions. Also note that this term is classified as a type of abnormal cell shape, because under a given set of conditions wild-type cells are never seen with the proportions (length:width ratio) observed in elongated cells. Small cells, in contrast, have the same proportions as a subset of wild-type cells, and simply do not grow to the full length seen in wild type. This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "cell morphology, elongated cell during nitrogen starvation" EXACT [PomBase:mah] synonym: "elongated cell during nitrogen depletion" EXACT [PomBase:vw] synonym: "elongated cell during nitrogen deprivation" EXACT [PomBase:vw] synonym: "long cell during nitrogen starvation" EXACT [PomBase:vw] is_a: FYPO:0000017 ! elongated cell is_a: FYPO:0000995 ! abnormal cell morphology during nitrogen starvation intersection_of: PATO:0000573 ! increased length intersection_of: exists_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in CL:0000000 ! cell relationship: exists_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in CL:0000000 ! cell created_by: midori creation_date: 2012-04-25T02:41:23Z [Term] id: FYPO:0000999 name: enlarged nucleus during nitrogen starvation def: "A physical cellular phenotype in which the nucleus is larger than normal when the cell is subject to nitrogen starvation." [PMID:19366728, PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "enlarged nuclei during nitrogen starvation" EXACT [PomBase:vw] synonym: "enlarged nucleus during nitrogen depletion" EXACT [PomBase:vw] synonym: "enlarged nucleus during nitrogen deprivation" EXACT [PomBase:vw] is_a: FYPO:0002255 ! enlarged nucleus intersection_of: PATO:0000586 ! increased size intersection_of: exists_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in GO:0005634 ! nucleus relationship: exists_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in GO:0005634 ! nucleus created_by: midori creation_date: 2012-04-25T03:07:07Z [Term] id: FYPO:0001000 name: normal cell cycle arrest in mitotic G1 phase during nitrogen starvation def: "A cellular process phenotype in which progression through the mitotic cell cycle is arrested normally in G1 phase when the cell is subject to nitrogen starvation." [PMID:19366728, PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "mitotic G1 phase arrest during nitrogen starvation" EXACT [PomBase:mah] synonym: "normal cell cycle arrest in mitotic G1 phase during nitrogen depletion" EXACT [PomBase:vw] synonym: "normal cell cycle arrest in mitotic G1 phase during nitrogen deprivation" EXACT [PomBase:vw] synonym: "normal mitotic cell cycle arrest in G1 phase during nitrogen starvation" EXACT [PomBase:mah] is_a: FYPO:0000445 ! cell cycle arrest in mitotic G1 phase is_a: FYPO:0001025 ! normally arrested mitotic cell cycle progression intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0030996 ! mitotic cell cycle arrest in response to nitrogen starvation intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0030996 ! mitotic cell cycle arrest in response to nitrogen starvation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-04-25T03:36:56Z [Term] id: FYPO:0001001 name: abnormal cell cycle arrest in mitotic G2 phase during nitrogen starvation def: "A cellular process phenotype in which progression through the mitotic cell cycle is arrested in G2 phase, instead of the normal G1 phase, when the cell is subject to nitrogen starvation." [PMID:19366728, PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "abnormal cell cycle arrest in mitotic G2 phase during nitrogen depletion" EXACT [PomBase:vw] synonym: "abnormal cell cycle arrest in mitotic G2 phase during nitrogen deprivation" EXACT [PomBase:vw] synonym: "abnormal mitotic cell cycle arrest in G2 phase during nitrogen starvation" EXACT [PomBase:mah] synonym: "advanced nitrogen deprivation-induced G1 arrest" EXACT [PomBase:vw] synonym: "cell cycle arrest in mitotic G2 phase during nitrogen starvation" EXACT [PomBase:mah] synonym: "mitotic G2 phase arrest during nitrogen starvation" EXACT [PomBase:mah] is_a: FYPO:0000710 ! abnormal mitotic cell cycle arrest in response to nitrogen starvation is_a: FYPO:0001151 ! cell cycle arrest in mitotic G2 phase during starvation is_a: FYPO:0003373 ! abnormal cell cycle arrest in mitotic G2 phase intersection_of: PATO:0001561 ! having extra processual parts intersection_of: during GO:0000085 ! mitotic G2 phase intersection_of: during GO:0006995 ! cellular response to nitrogen starvation intersection_of: towards GO:0071850 ! mitotic cell cycle arrest relationship: during GO:0000085 ! mitotic G2 phase relationship: during GO:0006995 ! cellular response to nitrogen starvation relationship: towards GO:0071850 ! mitotic cell cycle arrest created_by: midori creation_date: 2012-04-25T03:39:33Z [Term] id: FYPO:0001002 name: abolished cell division prior to G0 entry def: "A cellular process phenotype in which a cell does not undergo the normal two rounds of cell division prior to entering quiescence (G0)." [PMID:19366728, PomBase:mah] synonym: "cell division prior to G0 entry abolished" EXACT [PomBase:mah] synonym: "loss of pre-quiescence cell divisions following nitrogen starvation" EXACT [PomBase:al] is_a: FYPO:0000427 ! abnormal G1 to G0 transition created_by: midori creation_date: 2012-04-25T03:42:48Z [Term] id: FYPO:0001003 name: small vacuoles present in greater numbers during nitrogen starvation def: "A cell phenotype in which a cell contains more, but smaller, vacuoles than normal when the cell is subject to nitrogen starvation." [PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "fragmented vacuoles during nitrogen starvation" RELATED [PomBase:mah] synonym: "small vacuoles present in greater numbers during nitrogen depletion" EXACT [PomBase:vw] synonym: "small vacuoles present in greater numbers during nitrogen deprivation" EXACT [PomBase:vw] synonym: "vacuole organization defects, fragmented vacuoles during nitrogen starvation" RELATED [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: has_part FYPO:0002787 ! small vacuoles intersection_of: has_part FYPO:0002790 ! vacuoles present in greater numbers relationship: exists_during GO:0006995 ! cellular response to nitrogen starvation relationship: has_part FYPO:0002787 ! small vacuoles relationship: has_part FYPO:0002790 ! vacuoles present in greater numbers created_by: midori creation_date: 2012-04-25T03:48:58Z [Term] id: FYPO:0001004 name: viable upon G0 to G1 transition def: "A cell phenotype in which cells to resume growth normally upon exiting G0 phase." [PMID:19366728, PomBase:mah] is_a: FYPO:0000124 ! viable cell is_a: FYPO:0000257 ! normal phenotype intersection_of: FYPO:0000124 ! viable cell intersection_of: during GO:0045023 ! G0 to G1 transition relationship: during GO:0045023 ! G0 to G1 transition created_by: midori creation_date: 2012-04-25T03:50:33Z [Term] id: FYPO:0001005 name: fragmented DNA during nitrogen starvation def: "A cell phenotype in which DNA is broken into small fragments when the cell is subject to nitrogen starvation." [PMID:19366728, PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "DNA fragmentation during nitrogen starvation" EXACT [PomBase:mah] synonym: "fragmented DNA during nitrogen depletion" EXACT [PomBase:vw] synonym: "fragmented DNA during nitrogen deprivation" EXACT [PomBase:vw] is_a: FYPO:0000160 ! fragmented DNA intersection_of: PATO:0001444 ! broken intersection_of: exists_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in CHEBI:16991 ! deoxyribonucleic acid relationship: exists_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in CHEBI:16991 ! deoxyribonucleic acid created_by: midori creation_date: 2012-04-25T04:01:19Z [Term] id: FYPO:0001006 name: inviable elongated multinucleate vegetative cell with central constriction def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell contains more than one nucleus, is elongated, is inviable, and has an abnormal shape featuring a constriction at the center of the cell, corresponding to the cell division site. In a cell with this phenotype, the diameter at the ends may be much greater than in wild-type cells. Septal material may accumulate in patches at the cell surface, but no septum forms." [PMID:8834798, PomBase:mah, PomBase:vw] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "elongated, multinucleate dumbbell-shaped cell" RELATED [PomBase:mah] synonym: "inviable elongated multinucleate cell with central constriction during vegetative growth" EXACT [PomBase:mah] synonym: "inviable elongated multinucleate vegetative cell with central constriction during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable elongated multinucleate vegetative cell with constricted region at cell division site" EXACT [PomBase:vw] synonym: "inviable, elongated, multinucleate dumbbell-shaped vegetative cell" RELATED [PomBase:mah] synonym: "long, multinucleate dumbbell-shaped cell" RELATED [PomBase:vw] synonym: "multinucleate dumbbell-shaped cell" RELATED [PomBase:mah] is_a: FYPO:0002024 ! inviable elongated multinucleate aseptate vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000061 ! multinucleate vegetative cell intersection_of: has_part FYPO:0000779 ! inviable elongated vegetative cell with central constriction intersection_of: has_part FYPO:0000949 ! aseptate intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000061 ! multinucleate vegetative cell relationship: has_part FYPO:0000779 ! inviable elongated vegetative cell with central constriction relationship: has_part FYPO:0000949 ! aseptate relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2012-04-25T04:07:50Z [Term] id: FYPO:0001007 name: normal mitosis def: "A cellular process phenotype in which mitosis is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "mitosis: normal" EXACT [PomBase:mah] synonym: "normal mitosis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal mitosis during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002741 ! normal mitotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0007067 ! mitotic nuclear division intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0007067 ! mitotic nuclear division relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-04-25T04:16:58Z [Term] id: FYPO:0001008 name: actomyosin contractile ring absent def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the actomyosin contractile ring is absent from the cell." [PomBase:mah] comment: In the absence of filamentous actin, a ring structure may form, but is not considered a contractile ring. synonym: "actomyosin contractile ring absent" EXACT [PomBase:vw] synonym: "actomyosin contractile ring absent during mitotic cell cycle" RELATED [PomBase:mah] synonym: "actomyosin contractile ring absent during vegetative growth" EXACT [PomBase:mah] synonym: "actomyosin contractile ring absent from cell" EXACT [PomBase:mah] synonym: "actomyosin contractile ring actin absent" NARROW [PomBase:mah] synonym: "contractile ring absent" EXACT [PomBase:vw] synonym: "cytokinetic contractile ring absent" EXACT [PomBase:vw] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: PATO:0002000 ! lacks all parts of type intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards GO:0005826 ! actomyosin contractile ring relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards GO:0005826 ! actomyosin contractile ring created_by: midori creation_date: 2012-04-25T04:19:40Z [Term] id: FYPO:0001009 name: abolished actomyosin contractile ring assembly def: "A cytokinesis phenotype observed in the vegetative growth phase of the life cycle in which the assembly and distribution of actin filament bundles does not occur, resulting in the failure to form an actomyosin contractile ring." [PMID:19713940, PomBase:mah] comment: Note that a ring structure may form without filamentous actin, but a ring lacking F-actin is not considered a contractile ring. synonym: "abolished actomyosin contractile ring assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished actomyosin contractile ring assembly during vegetative growth" EXACT [PomBase:mah] synonym: "abolished actomyosin contractile ring formation" RELATED [GO:0000915, PomBase:mah] synonym: "abolished contractile ring assembly" EXACT [PomBase:mah] synonym: "abolished cytokinetic contractile ring assembly" EXACT [PomBase:vw] synonym: "abolished cytokinetic ring assembly" RELATED [PomBase:vw] synonym: "abolished cytokinetic ring formation" RELATED [PomBase:vw] synonym: "abolished mitotic contractile ring assembly" EXACT [PomBase:vw] synonym: "actomyosin contractile ring assembly abolished" EXACT [PomBase:mah] synonym: "cytokinesis defects, contractile ring actin, absent" RELATED [PomBase:mah] is_a: FYPO:0000161 ! abnormal actomyosin contractile ring assembly is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0000915 ! actomyosin contractile ring assembly relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_output FYPO:0001008 ! actomyosin contractile ring absent relationship: towards GO:0000915 ! actomyosin contractile ring assembly created_by: midori creation_date: 2012-04-25T04:37:10Z [Term] id: FYPO:0001010 name: abolished actin filament organization def: "A cytokinesis phenotype observed in the vegetative growth phase of the life cycle in which the assembly and distribution of cytoskeletal structures comprising actin filaments does not occur." [PomBase:mah] synonym: "abolished actin filament organisation" EXACT [PomBase:mah] synonym: "abolished actin filament organization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished actin filament organization during vegetative growth" EXACT [PomBase:mah] synonym: "actin filament organization abolished" EXACT [PomBase:mah] is_a: FYPO:0000727 ! abnormal actin filament organization during vegetative growth is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0007015 ! actin filament organization relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_output FYPO:0001011 ! filamentous actin absent relationship: towards GO:0007015 ! actin filament organization created_by: midori creation_date: 2012-04-25T04:55:17Z [Term] id: FYPO:0001011 name: filamentous actin absent def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells do not contain filamentous actin structures, such as cortical patches or dots, or rings." [PomBase:mah] synonym: "actin filaments absent" EXACT [PomBase:mah] synonym: "F-actin absent" EXACT [PomBase:mah] synonym: "filamentous actin absent during mitotic cell cycle" RELATED [PomBase:mah] synonym: "filamentous actin absent during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003684 ! altered level of macromolecular complex is_a: PATO:0002000 ! lacks all parts of type intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards GO:0031941 ! filamentous actin relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards GO:0031941 ! filamentous actin created_by: midori creation_date: 2012-04-25T04:58:49Z [Term] id: FYPO:0001012 name: growth auxotrophic for uracil def: "Auxotrophy in which a cell is unable to synthesize uracil, and therefore requires uracil in the medium for vegetative cell growth." [PomBase:mah] synonym: "growth auxotrophic for uracil during mitotic cell cycle" RELATED [PomBase:mah] synonym: "growth auxotrophic for uracil during vegetative growth" EXACT [PomBase:mah] synonym: "uracil auxotrophy" EXACT [PomBase:mah] is_a: FYPO:0000128 ! auxotrophy is_a: PATO:0000422 ! auxotrophic intersection_of: PATO:0000422 ! auxotrophic intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:17568 ! uracil relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:17568 ! uracil created_by: midori creation_date: 2012-04-26T12:15:11Z [Term] id: FYPO:0001013 name: abnormal membrane organization def: "A cellular process phenotype in which cellular membrane organization is abnormal. Cellular membrane organization results in the assembly, arrangement of constituent parts, or disassembly of a lipid bilayer membrane, such as the plasma membrane or an organelle membrane." [GO:0061024, PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "abnormal cellular membrane organization" EXACT [GO:0061024, PomBase:mah] synonym: "abnormal membrane organisation" EXACT [PomBase:mah] is_a: FYPO:0000335 ! abnormal cellular component organization intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0061024 ! membrane organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0061024 ! membrane organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-04-26T12:57:24Z [Term] id: FYPO:0001014 name: abnormal membrane organization during nitrogen starvation def: "A cellular process phenotype in which cellular membrane organization is abnormal when the cell is subject to nitrogen starvation." [PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "abnormal cellular membrane organization during nitrogen starvation" EXACT [GO:0061024, PomBase:mah] synonym: "abnormal membrane organisation during nitrogen starvation" EXACT [PomBase:mah] synonym: "abnormal membrane organization during nitrogen depletion" EXACT [PomBase:vw] synonym: "abnormal membrane organization during nitrogen deprivation" EXACT [PomBase:vw] is_a: FYPO:0001013 ! abnormal membrane organization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in_part_of GO:0061024 ! membrane organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in_part_of GO:0061024 ! membrane organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-04-26T12:59:57Z [Term] id: FYPO:0001015 name: altered cellular phosphatidylinositol-4-phosphate level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of phosphatidylinositol-4-phosphate measured in a cell differs from normal." [PomBase:mah] synonym: "abnormal cellular phosphatidylinositol-4-phosphate level" EXACT [PomBase:mah] synonym: "altered cellular phosphatidylinositol-4-phosphate level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "altered cellular phosphatidylinositol-4-phosphate level during vegetative growth" EXACT [PomBase:mah] synonym: "altered cellular PI-4-P level" EXACT [PomBase:al] synonym: "altered PI-4-P accumulation" RELATED [PomBase:al] is_a: FYPO:0001290 ! altered cellular phosphoinositide level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:37530 ! phosphatidylinositol 4-phosphate relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:37530 ! phosphatidylinositol 4-phosphate created_by: midori creation_date: 2012-04-25T02:15:24Z [Term] id: FYPO:0001016 name: normal growth on actinomycin D def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing actinomycin D." [PomBase:mah] synonym: "normal cell population growth in presence of actinomycin D" EXACT [PomBase:mah] synonym: "normal cell population growth on actinomycin D" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to actinomycin D" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on actinomycin D" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:27666 ! actinomycin D relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:27666 ! actinomycin D created_by: midori creation_date: 2012-04-26T03:36:00Z [Term] id: FYPO:0001017 name: premature activation of bipolar cell growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which activation of bipolar cell growth occurs prematurely; results in early occurrence of new end take-off." [PomBase:mah] synonym: "advanced activation of bipolar cell growth" EXACT [PomBase:mah] synonym: "early NETO" EXACT [PomBase:mah] synonym: "premature activation of bipolar vegetative cell growth" EXACT [PomBase:mah] synonym: "premature NETO" EXACT [PomBase:mah] synonym: "premature new end take-off" EXACT [PomBase:mah] is_a: FYPO:0000147 ! abnormal activation of bipolar cell growth is_a: PATO:0000694 ! premature intersection_of: PATO:0000694 ! premature intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051519 ! activation of bipolar cell growth relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051519 ! activation of bipolar cell growth created_by: midori creation_date: 2012-04-30T11:46:57Z [Term] id: FYPO:0001018 name: abolished activation of bipolar cell growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which activation of bipolar cell growth does not occur; results in absence of new end take-off." [PomBase:mah] synonym: "abolished activation of bipolar vegetative cell growth" EXACT [PomBase:mah] synonym: "abolished NETO" EXACT [PomBase:mah] synonym: "abolished new end take-off" EXACT [PomBase:mah] synonym: "absence of NETO" EXACT [PomBase:vw] synonym: "activation of bipolar cell growth abolished" EXACT [PomBase:mah] is_a: FYPO:0000147 ! abnormal activation of bipolar cell growth is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0051519 ! activation of bipolar cell growth relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_output FYPO:0001391 ! mislocalized septum, near new end relationship: towards GO:0051519 ! activation of bipolar cell growth created_by: midori creation_date: 2012-04-30T11:49:16Z [Term] id: FYPO:0001019 name: monopolar actin cortical patch localization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which actin cortical patches are localized to only one end of a cell." [PomBase:mah] synonym: "monopolar actin cortical patch localisation" EXACT [PomBase:mah] synonym: "monopolar actin cortical patch localization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "monopolar actin cortical patch localization during vegetative growth" EXACT [PomBase:mah] synonym: "monopolar actin cortical patch location" RELATED [PomBase:mah] is_a: FYPO:0003988 ! mislocalized actin cortical patches created_by: midori creation_date: 2012-04-30T02:17:33Z [Term] id: FYPO:0001020 name: normal growth on calcium ion def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing calcium ions." [PomBase:mah] synonym: "normal cell population growth in presence of calcium ions" EXACT [PomBase:mah] synonym: "normal cell population growth on calcium" EXACT [PomBase:mah] synonym: "normal cell population growth on calcium ion" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to calcium ion" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on calcium ion" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:29108 ! calcium(2+) relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:29108 ! calcium(2+) created_by: midori creation_date: 2012-04-30T02:48:06Z [Term] id: FYPO:0001021 name: normal growth during cellular response to osmotic stress def: "A cell growth phenotype in which cell population growth is normal (i.e. indistinguishable from wild type) during a cellular response to osmotic stress." [PomBase:mah] synonym: "normal cell population growth during cellular response to osmotic stress" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to osmotic stress" RELATED [PomBase:mah] synonym: "normal vegetative cell population growth during cellular response to osmotic stress" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: happens_during GO:0071470 ! cellular response to osmotic stress relationship: happens_during GO:0071470 ! cellular response to osmotic stress created_by: midori creation_date: 2012-04-30T02:50:20Z [Term] id: FYPO:0001022 name: normal growth during cellular response to high osmolarity def: "A cell growth phenotype in which cell population growth is normal (i.e. indistinguishable from wild type) during a cellular response to high osmolarity." [PomBase:mah] synonym: "normal cell population growth during cellular response to high osmolarity" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cell population growth during cellular response to hyperosmotic conditions" EXACT [PomBase:mah] synonym: "normal cellular response to high osmolarity" RELATED [PomBase:mah] synonym: "normal vegetative cell population growth during cellular response to high osmolarity" EXACT [PomBase:mah] is_a: FYPO:0001021 ! normal growth during cellular response to osmotic stress intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: happens_during GO:0071474 ! cellular hyperosmotic response relationship: happens_during GO:0071474 ! cellular hyperosmotic response created_by: midori creation_date: 2012-04-30T02:50:58Z [Term] id: FYPO:0001023 name: normal growth on cisplatin def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing cisplatin." [PomBase:mah] synonym: "normal cell population growth in presence of cisplatin" EXACT [PomBase:mah] synonym: "normal cell population growth on cisplatin" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to cisplatin" RELATED [PomBase:al, PomBase:mah] synonym: "normal growth on cis-DDP" EXACT [CHEBI:27899] synonym: "normal vegetative cell population growth on cisplatin" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:27899 ! cisplatin relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:27899 ! cisplatin created_by: midori creation_date: 2012-04-30T02:59:00Z [Term] id: FYPO:0001024 name: cell cycle arrest phenotype def: "A cell cycle phenotype that affects or involves the normal or abnormal occurrence of cell cycle arrest. In cell cycle arrest, progression through the cell cycle is halted during one of the normal phases (G1, S, G2, or M)." [PomBase:mah] subset: qc_do_not_manually_annotate synonym: "fission yeast cell cycle arrest phenotype" EXACT [PomBase:mah] is_a: FYPO:0000145 ! regulation phenotype is_a: FYPO:0000631 ! cell cycle phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: inheres_in_part_of GO:0007050 ! cell cycle arrest relationship: inheres_in_part_of GO:0007050 ! cell cycle arrest created_by: midori creation_date: 2012-05-09T01:15:41Z [Term] id: FYPO:0001025 name: normally arrested mitotic cell cycle progression def: "A cellular process phenotype in which mitotic cell cycle progression is arrested under conditions where arrest normally occurs." [PomBase:mah] synonym: "normal mitotic cell cycle arrest" EXACT [PomBase:mah] is_a: FYPO:0000627 ! normal cellular process is_a: FYPO:0004040 ! mitotic cell cycle arrest phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0071850 ! mitotic cell cycle arrest intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0071850 ! mitotic cell cycle arrest relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-05-09T01:38:00Z [Term] id: FYPO:0001026 name: abnormal occurrence of normal mitotic cell cycle arrest def: "A cellular process phenotype in which a mitotic cell cycle arrest that normally occurs is abnormal (does not occur, or occurs abnormally)." [PomBase:mah] is_a: FYPO:0002734 ! abnormal cell cycle process is_a: FYPO:0004040 ! mitotic cell cycle arrest phenotype created_by: midori creation_date: 2012-05-09T01:43:53Z [Term] id: FYPO:0001027 name: normal cell cycle arrest in mitotic G2 phase during glucose starvation def: "A cellular process phenotype in which progression through the mitotic cell cycle is arrested normally in G2 phase when the cell is subject to glucose starvation." [PomBase:al, PomBase:mah] synonym: "mitotic G1 phase arrest during glucose starvation" EXACT [PomBase:mah] synonym: "normal cell cycle arrest in mitotic G2 phase during glucose depletion" EXACT [PomBase:vw] synonym: "normal cell cycle arrest in mitotic G2 phase during glucose deprivation" EXACT [PomBase:vw] synonym: "normal mitotic cell cycle arrest in G2 phase during glucose starvation" EXACT [PomBase:mah] is_a: FYPO:0001025 ! normally arrested mitotic cell cycle progression is_a: FYPO:0001151 ! cell cycle arrest in mitotic G2 phase during starvation intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0036227 ! mitotic G2 cell cycle arrest in response to glucose starvation intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0036227 ! mitotic G2 cell cycle arrest in response to glucose starvation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-05-09T01:54:19Z [Term] id: FYPO:0001028 name: abnormal cell cycle arrest in mitotic interphase def: "A cellular process phenotype in which progression through the mitotic cell cycle is arrested in any part of interphase, under conditions where arrest is not a normal occurrence." [PomBase:mah] synonym: "abnormal mitotic cell cycle arrest in interphase" EXACT [PomBase:mah] synonym: "abnormal mitotic interphase cell cycle arrest" EXACT [PomBase:mah] is_a: FYPO:0000502 ! abnormally arrested mitotic cell cycle progression is_a: FYPO:0000837 ! cell cycle arrest in mitotic interphase intersection_of: PATO:0001561 ! having extra processual parts intersection_of: during GO:0051329 ! mitotic interphase intersection_of: towards GO:0071850 ! mitotic cell cycle arrest relationship: during GO:0051329 ! mitotic interphase relationship: towards GO:0071850 ! mitotic cell cycle arrest created_by: midori creation_date: 2012-05-09T02:46:23Z [Term] id: FYPO:0001029 name: resistance to canavanine def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of canavanine than normal." [PomBase:mah] synonym: "resistance to canavanine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to canavanine during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to canavanine" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:609827 ! L-canavanine relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:609827 ! L-canavanine created_by: midori creation_date: 2012-05-15T16:55:19Z [Term] id: FYPO:0001030 name: normal growth on dithiothreitol def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing dithiothreitol." [PomBase:mah] synonym: "normal cell population growth in presence of dithiothreitol" EXACT [PomBase:mah] synonym: "normal cell population growth on 1,4-dithiothreitol" EXACT [CHEBI:18320] synonym: "normal cell population growth on dithiothreitol" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cell population growth on DTT" EXACT [PomBase:mah] synonym: "normal cellular response to dithiothreitol" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on dithiothreitol" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:18320 ! 1,4-dithiothreitol relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:18320 ! 1,4-dithiothreitol created_by: midori creation_date: 2012-05-09T04:26:29Z [Term] id: FYPO:0001031 name: accumulation of single-strand break sites def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the number of sites of single-strand breaks in DNA is greater than normal." [PomBase:mah] comment: Because Rad22 often accumulates at double-strand breaks, consider also annotating to 'increased number of Rad22 foci' (FYPO:0000972). synonym: "accumulation of single-strand break sites" EXACT [PomBase:mah] synonym: "accumulation of single-strand break sites during mitotic cell cycle" RELATED [PomBase:mah] synonym: "accumulation of single-strand break sites during vegetative growth" EXACT [PomBase:mah] synonym: "increased number of single-strand break sites during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001321 ! cellular physical quality phenotype during vegetative growth created_by: midori creation_date: 2012-05-09T04:33:36Z [Term] id: FYPO:0001032 name: resistance to camptothecin def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of camptothecin than normal." [PomBase:mah] synonym: "resistance to camptothecin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to camptothecin during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to camptothecin" EXACT [PomBase:mah] synonym: "resistant to CPT" EXACT [CHEBI:27656, PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:27656 ! camptothecin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:27656 ! camptothecin created_by: midori creation_date: 2012-05-09T04:35:09Z [Term] id: FYPO:0001033 name: normal double-strand break repair def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which double-strand break repair is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal double-strand break repair during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal double-strand break repair during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000859 ! normal metabolic process during vegetative growth is_a: FYPO:0000968 ! normal cellular response to stress intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006302 ! double-strand break repair intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006302 ! double-strand break repair relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-05-09T04:36:23Z [Term] id: FYPO:0001034 name: resistance to tunicamycin def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of tunicamycin than normal." [PomBase:mah] synonym: "resistance to tunicamycin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to tunicamycin during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to TM" EXACT [PomBase:al] synonym: "resistant to tunicamycin" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:29699 ! tunicamycin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:29699 ! tunicamycin created_by: midori creation_date: 2012-05-09T04:43:09Z [Term] id: FYPO:0001035 name: increased cell wall thickness during vegetative growth def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the fungal-type cell wall is thicker than normal." [PomBase:mah] synonym: "increased cell wall thickness during mitotic cell cycle" RELATED [PomBase:mah] synonym: "thickened cell wall during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000351 ! abnormal cell wall morphology during vegetative growth is_a: PATO:0000591 ! increased thickness intersection_of: PATO:0000591 ! increased thickness intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0009277 ! fungal-type cell wall relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0009277 ! fungal-type cell wall created_by: midori creation_date: 2012-05-09T04:44:26Z [Term] id: FYPO:0001036 name: delaminated cell wall during vegetative growth def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the fungal-type cell wall is delaminated, i.e. one or more of its layers peels off." [PomBase:al, PomBase:mah] synonym: "delaminate cell wall during vegetative growth" EXACT [PomBase:mah] synonym: "delaminated cell wall during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000351 ! abnormal cell wall morphology during vegetative growth is_a: FYPO:0002948 ! delaminated cell wall intersection_of: PATO:0001514 ! delaminated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0009277 ! fungal-type cell wall relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0009277 ! fungal-type cell wall created_by: midori creation_date: 2012-05-09T04:45:40Z [Term] id: FYPO:0001037 name: normal growth during cellular response to salt stress def: "A cell growth phenotype in which cell population growth is normal (i.e. indistinguishable from wild type) during a cellular response to salt stress." [PomBase:mah] synonym: "normal cell population growth during cellular response to ionic osmotic stress" EXACT [GO:0071472, PomBase:mah] synonym: "normal cell population growth during cellular response to salt stress" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to salt stress" RELATED [PomBase:mah] synonym: "normal cellular salinity response" RELATED [GO:0071472, PomBase:mah] synonym: "normal vegetative cell population growth during cellular response to salt stress" EXACT [PomBase:mah] is_a: FYPO:0001021 ! normal growth during cellular response to osmotic stress intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: happens_during GO:0071472 ! cellular response to salt stress relationship: happens_during GO:0071472 ! cellular response to salt stress created_by: midori creation_date: 2012-05-09T04:57:53Z [Term] id: FYPO:0001038 name: increased protein phosphorylation during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins occurs to a greater extent than normal." [PomBase:mah] synonym: "increased protein phosphorylation during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000547 ! increased protein modification during vegetative growth is_a: FYPO:0000775 ! abnormal protein phosphorylation during vegetative growth is_a: FYPO:0002680 ! increased protein phosphorylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2012-05-09T05:01:01Z [Term] id: FYPO:0001039 name: abnormal thiamine diphosphokinase activity def: "A molecular function phenotype in which the observed rate of thiamine diphosphokinase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004788 ! thiamine diphosphokinase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004788 ! thiamine diphosphokinase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-05-09T05:07:50Z [Term] id: FYPO:0001040 name: decreased thiamine diphosphokinase activity def: "A molecular function phenotype in which the observed rate of thiamine diphosphokinase activity is decreased." [PomBase:mah] synonym: "reduced thiamine diphosphokinase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0001039 ! abnormal thiamine diphosphokinase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004788 ! thiamine diphosphokinase activity relationship: inheres_in GO:0004788 ! thiamine diphosphokinase activity created_by: midori creation_date: 2012-05-09T05:07:58Z [Term] id: FYPO:0001041 name: increased cellular thiamine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of thiamine measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular thiamine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular thiamine level during vegetative growth" EXACT [PomBase:mah] synonym: "increased thiamine accumulation" RELATED [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:26948 ! thiamine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:26948 ! thiamine created_by: midori creation_date: 2012-05-09T05:09:40Z [Term] id: FYPO:0001042 name: inviable after spore germination, single or double cell division def: "A phenotype in which a spore germinates to produce a cell of normal morphology that undergoes one or two rounds of cell division, and then dies." [PomBase:al, PomBase:mah] synonym: "essential; germinating spore, single or double cell division" RELATED [PomBase:mah] synonym: "inviable following spore germination, single or double cell division" EXACT [PomBase:mah] synonym: "inviable germinated spore, single or double cell division" EXACT [PomBase:mah] is_a: FYPO:0000316 ! inviable after spore germination created_by: midori creation_date: 2012-05-09T05:12:57Z [Term] id: FYPO:0001043 name: increased mating efficiency def: "A biological process phenotype in which the observed mating efficiency is higher than normal." [PomBase:al, PomBase:mah] comment: Note that mating efficiency is often measured by counting zygotes plus asci, sometimes also including spores, so a change in measured mating efficiency may reflect a change in conjugation frequency (see FYPO:0000031 and its descendants), a change in sporulation (see FYPO:0000121 and its descendants), or both. For this reason, this term is not a child of 'mating phenotype' (FYPO:0000031). synonym: "mating efficiency: increased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000003 ! cell population phenotype created_by: midori creation_date: 2012-05-09T05:15:28Z [Term] id: FYPO:0001044 name: abnormal acid phosphatase activity def: "A molecular function phenotype in which the observed rate of acid phosphatase activity is abnormal." [PomBase:mah] is_a: FYPO:0004302 ! abnormal phosphatase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0003993 ! acid phosphatase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0003993 ! acid phosphatase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-05-10T04:20:28Z [Term] id: FYPO:0001045 name: decreased acid phosphatase activity def: "A molecular function phenotype in which the observed rate of acid phosphatase activity is decreased." [PomBase:mah] synonym: "reduced acid phosphatase activity" EXACT [PomBase:mah] is_a: FYPO:0001044 ! abnormal acid phosphatase activity is_a: FYPO:0004304 ! decreased phosphatase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0003993 ! acid phosphatase activity relationship: inheres_in GO:0003993 ! acid phosphatase activity created_by: midori creation_date: 2012-05-10T04:20:35Z [Term] id: FYPO:0001046 name: premature mitosis def: "A cellular process phenotype in which cells enter mitosis earlier, relative to cell size or DNA integrity checkpoint status, than normal." [PomBase:mah] comment: Also consider annotating to 'viable small vegetative cell' (FYPO:0000648), if mitosis takes place when cells are smaller than normal. synonym: "advanced mitosis" EXACT [PomBase:mah] synonym: "early mitosis" EXACT [PomBase:mah] synonym: "premature mitosis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "premature mitosis during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001204 ! mistimed mitosis is_a: PATO:0000694 ! premature intersection_of: PATO:0000694 ! premature intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0007067 ! mitotic nuclear division relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0007067 ! mitotic nuclear division created_by: midori creation_date: 2012-05-11T01:28:00Z [Term] id: FYPO:0001047 name: mitotic catastrophe def: "An inviable phenotype in which a cell enters mitosis prematurely, undergoes abnormal mitotic chromosome segregation, and subsequently dies." [PomBase:mah] comment: Note that in higher eukaryotes, mitotic catastrophe is more broadly defined as any phenotype in which cells undergo an aberrant mitosis that arrests before completion, and subsequently die by necrosis or apoptosis. synonym: "mitotic catastrophe during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000141 ! abnormal mitotic sister chromatid segregation intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000141 ! abnormal mitotic sister chromatid segregation relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2012-05-11T01:34:45Z [Term] id: FYPO:0001048 name: mitotic catastrophe with cut def: "An inviable phenotype in which a cell undergoes mitotic catastrophe (i.e. enters mitosis prematurely and with defective chromosome segregation), and then septates to give rise to a cut phenotype. In a cut phenotype, a cell undergoes septation despite abnormal chromosome segregation, such that the septum physically divides the nucleus into two parts, and produces inviable daughter cells." [PomBase:mah] synonym: "cut with mitotic catastrophe" EXACT [PomBase:mah] synonym: "mitotic catastrophe with cut during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001047 ! mitotic catastrophe intersection_of: FYPO:0000002 ! cell phenotype intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000141 ! abnormal mitotic sister chromatid segregation intersection_of: has_part FYPO:0001204 ! mistimed mitosis intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0003165 ! cut relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000141 ! abnormal mitotic sister chromatid segregation relationship: has_part FYPO:0001204 ! mistimed mitosis relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0003165 ! cut created_by: midori creation_date: 2012-05-11T01:37:41Z [Term] id: FYPO:0001049 name: mitotic catastrophe, small cell def: "An inviable phenotype in which a cell undergoes mitotic catastrophe (i.e. enters mitosis prematurely and with defective chromosome segregation), entering mitosis when smaller than wild type." [PomBase:mah] synonym: "mitotic catastrophe, small cell during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001047 ! mitotic catastrophe intersection_of: FYPO:0000002 ! cell phenotype intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000141 ! abnormal mitotic sister chromatid segregation intersection_of: has_part FYPO:0000951 ! inviable small vegetative cell intersection_of: has_part FYPO:0001204 ! mistimed mitosis intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000141 ! abnormal mitotic sister chromatid segregation relationship: has_part FYPO:0000951 ! inviable small vegetative cell relationship: has_part FYPO:0001204 ! mistimed mitosis relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2012-05-11T01:59:31Z [Term] id: FYPO:0001050 name: mitotic catastrophe, normal size cell def: "An inviable phenotype in which a cell undergoes mitotic catastrophe (i.e. enters mitosis prematurely and with defective chromosome segregation), entering mitosis at the same size as wild type." [PomBase:mah] comment: Note that mitotic catastrophe in normal-size cells is usually interpreted to mean that cells enter mitosis despite failing to activate a DNA integrity checkpoint. synonym: "mitotic catastrophe, normal size cell during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001047 ! mitotic catastrophe intersection_of: FYPO:0000002 ! cell phenotype intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000141 ! abnormal mitotic sister chromatid segregation intersection_of: has_part FYPO:0001124 ! normal vegetative cell size intersection_of: has_part FYPO:0001204 ! mistimed mitosis intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000141 ! abnormal mitotic sister chromatid segregation relationship: has_part FYPO:0001124 ! normal vegetative cell size relationship: has_part FYPO:0001204 ! mistimed mitosis relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2012-05-11T02:09:56Z [Term] id: FYPO:0001051 name: mitotic catastrophe, elongated cell def: "An inviable phenotype in which a cell undergoes mitotic catastrophe (i.e. enters mitosis prematurely and with defective chromosome segregation), entering mitosis when longer than wild type." [PomBase:mah] comment: Note that mitotic catastrophe in elongated cells is usually interpreted to mean that cells enter mitosis despite failing to maintain a DNA integrity checkpoint. synonym: "mitotic catastrophe, elongated cell during vegetative growth" EXACT [PomBase:mah] synonym: "mitotic catastrophe, long cell" EXACT [PomBase:vw] is_a: FYPO:0001047 ! mitotic catastrophe intersection_of: FYPO:0000002 ! cell phenotype intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000141 ! abnormal mitotic sister chromatid segregation intersection_of: has_part FYPO:0001204 ! mistimed mitosis intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0001490 ! inviable elongated vegetative cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000141 ! abnormal mitotic sister chromatid segregation relationship: has_part FYPO:0001204 ! mistimed mitosis relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0001490 ! inviable elongated vegetative cell created_by: midori creation_date: 2012-05-11T02:16:25Z [Term] id: FYPO:0001052 name: mitotic catastrophe with cut, small cell def: "An inviable phenotype in which a cell undergoes mitotic catastrophe (i.e. enters mitosis prematurely and with defective chromosome segregation), entering mitosis when smaller than wild type, and then septates to give rise to a cut phenotype. In a cut phenotype, a cell undergoes septation despite abnormal chromosome segregation, such that the septum physically divides the nucleus into two parts, and produces inviable daughter cells." [PomBase:mah] synonym: "cut with mitotic catastrophe, small cell" EXACT [PomBase:mah] synonym: "mitotic catastrophe with cut, small cell during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001048 ! mitotic catastrophe with cut is_a: FYPO:0001049 ! mitotic catastrophe, small cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000141 ! abnormal mitotic sister chromatid segregation intersection_of: has_part FYPO:0000951 ! inviable small vegetative cell intersection_of: has_part FYPO:0001204 ! mistimed mitosis intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0003165 ! cut relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000141 ! abnormal mitotic sister chromatid segregation relationship: has_part FYPO:0000951 ! inviable small vegetative cell relationship: has_part FYPO:0001204 ! mistimed mitosis relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0003165 ! cut created_by: midori creation_date: 2012-05-11T02:38:12Z [Term] id: FYPO:0001053 name: mitotic catastrophe with cut, normal size cell def: "An inviable phenotype in which a cell undergoes mitotic catastrophe (i.e. enters mitosis prematurely and with defective chromosome segregation), entering mitosis at the same size as wild type, and then septates to give rise to a cut phenotype. In a cut phenotype, a cell undergoes septation despite abnormal chromosome segregation, such that the septum physically divides the nucleus into two parts, and produces inviable daughter cells." [PomBase:mah] synonym: "cut with mitotic catastrophe, normal size cell" EXACT [PomBase:mah] synonym: "mitotic catastrophe with cut, normal size cell during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001048 ! mitotic catastrophe with cut is_a: FYPO:0001050 ! mitotic catastrophe, normal size cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000141 ! abnormal mitotic sister chromatid segregation intersection_of: has_part FYPO:0001124 ! normal vegetative cell size intersection_of: has_part FYPO:0001204 ! mistimed mitosis intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0003165 ! cut relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000141 ! abnormal mitotic sister chromatid segregation relationship: has_part FYPO:0001124 ! normal vegetative cell size relationship: has_part FYPO:0001204 ! mistimed mitosis relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0003165 ! cut created_by: midori creation_date: 2012-05-11T02:39:40Z [Term] id: FYPO:0001054 name: mitotic catastrophe with cut, elongated cell def: "An inviable phenotype in which a cell undergoes mitotic catastrophe (i.e. enters mitosis prematurely and with defective chromosome segregation), entering mitosis when longer than wild type, and then septates to give rise to a cut phenotype. In a cut phenotype, a cell undergoes septation despite abnormal chromosome segregation, such that the septum physically divides the nucleus into two parts, and produces inviable daughter cells." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "cut with mitotic catastrophe, elongated cell" EXACT [PomBase:mah] synonym: "mitotic catastrophe with cut, elongated cell during vegetative growth" EXACT [PomBase:mah] synonym: "mitotic catastrophe with cut, long cell" EXACT [PomBase:vw] is_a: FYPO:0001048 ! mitotic catastrophe with cut is_a: FYPO:0001051 ! mitotic catastrophe, elongated cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000141 ! abnormal mitotic sister chromatid segregation intersection_of: has_part FYPO:0001204 ! mistimed mitosis intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0001490 ! inviable elongated vegetative cell intersection_of: has_part FYPO:0003165 ! cut relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000141 ! abnormal mitotic sister chromatid segregation relationship: has_part FYPO:0001204 ! mistimed mitosis relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0001490 ! inviable elongated vegetative cell relationship: has_part FYPO:0003165 ! cut created_by: midori creation_date: 2012-05-11T02:39:47Z [Term] id: FYPO:0001055 name: cut following normal mitotic entry def: "An inviable phenotype in which a cell enters mitosis normally, but then undergoes septation despite abnormal chromosome segregation, such that the septum physically divides the nucleus into two parts, and produces inviable daughter cells." [PomBase:mah] synonym: "cut following normal entry into mitosis" EXACT [PomBase:mah] synonym: "cut following normal mitotic entry during vegetative growth" EXACT [PomBase:mah] synonym: "cut with normal mitotic entry" EXACT [PomBase:mah] is_a: FYPO:0003165 ! cut created_by: midori creation_date: 2012-05-11T02:46:40Z [Term] id: FYPO:0001056 name: normal arginine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which L-arginine import into the cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal arginine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal arginine import during vegetative growth" EXACT [PomBase:mah] synonym: "normal arginine import into cell" EXACT [PomBase:al] synonym: "normal L-arginine import" EXACT [PomBase:mah] synonym: "normal L-arginine uptake" EXACT [PomBase:mah] is_a: FYPO:0001336 ! transport phenotype during vegetative growth is_a: FYPO:0001596 ! normal amino acid import intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902765 ! L-arginine import into cell intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902765 ! L-arginine import into cell relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-05-11T03:49:08Z [Term] id: FYPO:0001057 name: abnormal amino acid import def: "A cellular process phenotype in which the import of one or more amino acids into the cell is abnormal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "abnormal amino acid import into cell" EXACT [PomBase:al] synonym: "abnormal amino acid uptake" EXACT [PomBase:mah] is_a: FYPO:0001720 ! abnormal transport intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:1902837 ! amino acid import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:1902837 ! amino acid import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-05-11T03:54:42Z [Term] id: FYPO:0001058 name: decreased amino acid import def: "A cellular process phenotype in which the import of one or more amino acids into the cell occurs to a lower extent than normal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "decreased amino acid import into cell" EXACT [PomBase:al] synonym: "decreased amino acid uptake" EXACT [PomBase:mah] synonym: "reduced amino acid import" EXACT [PomBase:mah] is_a: FYPO:0001057 ! abnormal amino acid import is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:1902837 ! amino acid import into cell relationship: inheres_in GO:1902837 ! amino acid import into cell created_by: midori creation_date: 2012-05-11T03:55:46Z [Term] id: FYPO:0001059 name: abnormal glutamate import during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of glutamate into the cell is abnormal in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "abnormal glutamate import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal glutamate import into cell during vegetative growth" EXACT [PomBase:al] synonym: "abnormal glutamate uptake during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal L-glutamate import during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001361 ! abnormal amino acid import during vegetative growth is_a: FYPO:0001646 ! abnormal glutamate import intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1990123 ! L-glutamate import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1990123 ! L-glutamate import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-05-11T03:57:30Z [Term] id: FYPO:0001060 name: decreased glutamate import during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of glutamate into the cell occurs to a lower extent than normal in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "decreased glutamate import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased glutamate import into cell" EXACT [PomBase:al] synonym: "decreased glutamate uptake" EXACT [PomBase:mah] synonym: "decreased L-glutamate import" EXACT [PomBase:mah] synonym: "reduced glutamate import" EXACT [PomBase:mah] is_a: FYPO:0001059 ! abnormal glutamate import during vegetative growth is_a: FYPO:0001360 ! decreased amino acid import during vegetative growth is_a: FYPO:0001649 ! decreased glutamate import intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990123 ! L-glutamate import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990123 ! L-glutamate import into cell created_by: midori creation_date: 2012-05-11T04:06:25Z [Term] id: FYPO:0001061 name: abnormal glutamine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of glutamine into the cell is abnormal." [PomBase:mah] synonym: "abnormal glutamine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal glutamine import during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal glutamine import into cell" EXACT [PomBase:al] synonym: "abnormal glutamine uptake" EXACT [PomBase:mah] synonym: "abnormal L-glutamine import" NARROW [PomBase:mah] is_a: FYPO:0001361 ! abnormal amino acid import during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1903803 ! L-glutamine import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1903803 ! L-glutamine import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-05-11T04:08:09Z [Term] id: FYPO:0001062 name: decreased glutamine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of glutamine into the cell occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased glutamine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased glutamine import during vegetative growth" EXACT [PomBase:mah] synonym: "decreased glutamine import into cell" EXACT [PomBase:al] synonym: "decreased glutamine uptake" EXACT [PomBase:mah] synonym: "decreased L-glutamine import" NARROW [PomBase:mah] synonym: "reduced glutamine import" EXACT [PomBase:mah] is_a: FYPO:0001061 ! abnormal glutamine import is_a: FYPO:0001360 ! decreased amino acid import during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903803 ! L-glutamine import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903803 ! L-glutamine import into cell created_by: midori creation_date: 2012-05-11T04:08:19Z [Term] id: FYPO:0001063 name: abnormal glycine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of glycine into the cell is abnormal." [PomBase:mah] synonym: "abnormal glycine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal glycine import during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal glycine import into cell" EXACT [PomBase:al] synonym: "abnormal glycine uptake" EXACT [PomBase:mah] is_a: FYPO:0001361 ! abnormal amino acid import during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1903804 ! glycine import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1903804 ! glycine import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-05-11T04:10:09Z [Term] id: FYPO:0001064 name: decreased glycine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of glycine into the cell occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased glycine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased glycine import during vegetative growth" EXACT [PomBase:mah] synonym: "decreased glycine import into cell" EXACT [PomBase:al] synonym: "decreased glycine uptake" EXACT [PomBase:mah] synonym: "reduced glycine import" EXACT [PomBase:mah] is_a: FYPO:0001063 ! abnormal glycine import is_a: FYPO:0001360 ! decreased amino acid import during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903804 ! glycine import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903804 ! glycine import into cell created_by: midori creation_date: 2012-05-11T04:10:17Z [Term] id: FYPO:0001065 name: abnormal threonine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of threonine into the cell is abnormal." [PomBase:mah] synonym: "abnormal L-threonine import" EXACT [PomBase:mah] synonym: "abnormal threonine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal threonine import during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal threonine import into cell" EXACT [PomBase:al] synonym: "abnormal threonine uptake" EXACT [PomBase:mah] is_a: FYPO:0001361 ! abnormal amino acid import during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1903807 ! L-threonine import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1903807 ! L-threonine import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-05-11T04:11:34Z [Term] id: FYPO:0001066 name: decreased threonine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of threonine into the cell occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased L-threonine import" EXACT [PomBase:mah] synonym: "decreased threonine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased threonine import during vegetative growth" EXACT [PomBase:mah] synonym: "decreased threonine import into cell" EXACT [PomBase:al] synonym: "decreased threonine uptake" EXACT [PomBase:mah] synonym: "reduced threonine import" EXACT [PomBase:mah] is_a: FYPO:0001065 ! abnormal threonine import is_a: FYPO:0001360 ! decreased amino acid import during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903807 ! L-threonine import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903807 ! L-threonine import into cell created_by: midori creation_date: 2012-05-11T04:11:43Z [Term] id: FYPO:0001067 name: abnormal tyrosine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of tyrosine into the cell is abnormal." [PomBase:mah] synonym: "abnormal L-tyrosine import" EXACT [PomBase:mah] synonym: "abnormal tyrosine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal tyrosine import during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal tyrosine import into cell" EXACT [PomBase:al] synonym: "abnormal tyrosine uptake" EXACT [PomBase:mah] is_a: FYPO:0001361 ! abnormal amino acid import during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1903808 ! L-tyrosine import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1903808 ! L-tyrosine import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-05-11T04:14:15Z [Term] id: FYPO:0001068 name: decreased tyrosine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of tyrosine into the cell occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased L-tyrosine import" EXACT [PomBase:mah] synonym: "decreased tyrosine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased tyrosine import during vegetative growth" EXACT [PomBase:mah] synonym: "decreased tyrosine import into cell" EXACT [PomBase:al] synonym: "decreased tyrosine uptake" EXACT [PomBase:mah] synonym: "reduced tyrosine import" EXACT [PomBase:mah] is_a: FYPO:0001067 ! abnormal tyrosine import is_a: FYPO:0001360 ! decreased amino acid import during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903808 ! L-tyrosine import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903808 ! L-tyrosine import into cell created_by: midori creation_date: 2012-05-11T04:14:20Z [Term] id: FYPO:0001069 name: increased duration of mitotic cell cycle phase def: "A cellular process phenotype in which the duration of one or more mitotic cell cycle phases is longer than normal." [PomBase:mah] synonym: "increased duration of mitotic cell cycle phase during vegetative growth" EXACT [PomBase:mah] synonym: "prolonged mitotic cell cycle phase" EXACT [PomBase:mah] is_a: FYPO:0000408 ! increased duration of cell cycle phase is_a: FYPO:0002736 ! abnormal mitotic cell cycle phase intersection_of: PATO:0000498 ! increased duration intersection_of: during GO:0000278 ! mitotic cell cycle intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0022403 ! cell cycle phase relationship: during GO:0000278 ! mitotic cell cycle relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0022403 ! cell cycle phase created_by: midori creation_date: 2012-05-31T14:19:07Z [Term] id: FYPO:0001070 name: decreased duration of mitotic cell cycle phase def: "A cellular process phenotype in which the duration of one or more mitotic cell cycle phases is shorter than normal." [PomBase:mah] synonym: "decreased duration of mitotic cell cycle phase during vegetative growth" EXACT [PomBase:mah] synonym: "reduced duration of mitotic cell cycle phase" EXACT [PomBase:mah] is_a: FYPO:0000410 ! decreased duration of cell cycle phase is_a: FYPO:0002736 ! abnormal mitotic cell cycle phase intersection_of: PATO:0000499 ! decreased duration intersection_of: during GO:0000278 ! mitotic cell cycle intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0022403 ! cell cycle phase relationship: during GO:0000278 ! mitotic cell cycle relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0022403 ! cell cycle phase created_by: midori creation_date: 2012-05-31T14:19:54Z [Term] id: FYPO:0001071 name: normal transport def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transport is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal transport during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal transport during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001319 ! normal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006810 ! transport intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006810 ! transport relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-05-31T15:46:37Z [Term] id: FYPO:0001072 name: normal myo-inositol import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which myo-inositol import into the cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal myo-inositol import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal myo-inositol import during vegetative growth" EXACT [PomBase:mah] synonym: "normal myo-inositol import into cell" EXACT [PomBase:al] synonym: "normal myo-inositol uptake" EXACT [PomBase:mah] is_a: FYPO:0001071 ! normal transport is_a: FYPO:0001336 ! transport phenotype during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0097357 ! myo-inositol import into cell intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0097357 ! myo-inositol import into cell relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-05-31T15:59:13Z [Term] id: FYPO:0001073 name: abnormal myo-inositol import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of myo-inositol into the cell is abnormal." [PomBase:mah] synonym: "abnormal myo-inositol import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal myo-inositol import during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal myo-inositol import into cell" EXACT [PomBase:al] synonym: "abnormal myo-inositol uptake" EXACT [PomBase:mah] is_a: FYPO:0001336 ! transport phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0001720 ! abnormal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0097357 ! myo-inositol import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0097357 ! myo-inositol import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-05-31T16:00:28Z [Term] id: FYPO:0001074 name: decreased myo-inositol import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of myo-inositol into the cell occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased myo-inositol import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased myo-inositol import during vegetative growth" EXACT [PomBase:mah] synonym: "decreased myo-inositol import into cell" EXACT [PomBase:al] synonym: "decreased myo-inositol uptake" EXACT [PomBase:mah] synonym: "reduced myo-inositol import" EXACT [PomBase:mah] is_a: FYPO:0001073 ! abnormal myo-inositol import is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0097357 ! myo-inositol import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0097357 ! myo-inositol import into cell created_by: midori creation_date: 2012-05-31T16:00:49Z [Term] id: FYPO:0001075 name: normal growth on papulacandin B def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing papulacandin B." [PomBase:mah] synonym: "normal cell population growth in presence of papulacandin B" EXACT [PomBase:mah] synonym: "normal cell population growth on papulacandin B" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to papulacandin B" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on papulacandin B" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:569624 ! papulacandin B relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:569624 ! papulacandin B created_by: midori creation_date: 2012-05-31T16:05:26Z [Term] id: FYPO:0001076 name: normal level of substance in cell def: "A cell phenotype in which the amount of a specific substance measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate is_a: FYPO:0000136 ! cellular physical quality phenotype is_a: FYPO:0000257 ! normal phenotype is_a: PATO:0001159 ! concentrated intersection_of: PATO:0001159 ! concentrated intersection_of: inheres_in CL:0000000 ! cell intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:24431 ! chemical entity relationship: inheres_in CL:0000000 ! cell relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:24431 ! chemical entity created_by: midori creation_date: 2012-05-31T16:27:42Z [Term] id: FYPO:0001077 name: normal polysaccharide level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of a polysaccharide measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal polysaccharide accumulation" RELATED [PomBase:mah] synonym: "normal polysaccharide level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal polysaccharide level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:18154 ! polysaccharide relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:18154 ! polysaccharide created_by: midori creation_date: 2012-05-31T16:29:26Z [Term] id: FYPO:0001078 name: normal beta-glucan level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of beta-D-glucan measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal beta-D-glucan level" EXACT [CHEBI:28793, PomBase:mah] synonym: "normal beta-glucan accumulation" RELATED [PomBase:mah] synonym: "normal beta-glucan level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal beta-glucan level during vegetative growth" EXACT [PomBase:mah] synonym: "normal cellular beta-glucan level" EXACT [PomBase:al] is_a: FYPO:0001077 ! normal polysaccharide level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:28793 ! beta-D-glucan relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:28793 ! beta-D-glucan created_by: midori creation_date: 2012-05-31T16:30:57Z [Term] id: FYPO:0001079 name: normal galactomannan level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of galactomannan measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular galactomannan level" EXACT [PomBase:al] synonym: "normal galactomannan accumulation" RELATED [PomBase:mah] synonym: "normal galactomannan level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal galactomannan level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001077 ! normal polysaccharide level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:27680 ! galactomannan relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:27680 ! galactomannan created_by: midori creation_date: 2012-05-31T16:33:06Z [Term] id: FYPO:0001080 name: decreased polysaccharide level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of a polysaccharide measured in a cell is lower than normal." [PomBase:mah] synonym: "decreased cellular polysaccharide level" EXACT [PomBase:mah] synonym: "decreased polysaccharide accumulation" RELATED [PomBase:mah] synonym: "decreased polysaccharide level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased polysaccharide level during vegetative growth" EXACT [PomBase:mah] synonym: "reduced polysaccharide level" EXACT [PomBase:mah] is_a: FYPO:0001085 ! altered polysaccharide level is_a: FYPO:0001329 ! decreased level of substance in cell during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:18154 ! polysaccharide relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:18154 ! polysaccharide created_by: midori creation_date: 2012-05-31T16:33:42Z [Term] id: FYPO:0001081 name: decreased cell wall alpha-glucan level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of alpha-D-glucan measured in the cell wall is lower than normal." [PomBase:mah] synonym: "decreased cell wall alpha-D-glucan level" EXACT [CHEBI:22385, PomBase:mah] synonym: "decreased cell wall alpha-glucan accumulation" RELATED [PomBase:mah] synonym: "decreased cell wall alpha-glucan level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cell wall alpha-glucan level during vegetative growth" EXACT [PomBase:mah] synonym: "reduced cell wall alpha-glucan level" EXACT [PomBase:mah] is_a: FYPO:0002266 ! decreased cell wall polysaccharide level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0009277 ! fungal-type cell wall intersection_of: towards CHEBI:22385 ! alpha-D-glucan relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0009277 ! fungal-type cell wall relationship: towards CHEBI:22385 ! alpha-D-glucan created_by: midori creation_date: 2012-05-31T16:35:00Z [Term] id: FYPO:0001082 name: decreased cell wall beta-glucan level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of beta-D-glucan measured in the cell wall is lower than normal." [PomBase:mah] synonym: "decreased cell wall beta-D-glucan level" EXACT [CHEBI:28793, PomBase:mah] synonym: "decreased cell wall beta-glucan accumulation" RELATED [PomBase:mah] synonym: "decreased cell wall beta-glucan level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cell wall beta-glucan level during vegetative growth" EXACT [PomBase:mah] synonym: "reduced cell wall beta-glucan level" EXACT [PomBase:mah] is_a: FYPO:0002266 ! decreased cell wall polysaccharide level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0009277 ! fungal-type cell wall intersection_of: towards CHEBI:28793 ! beta-D-glucan relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0009277 ! fungal-type cell wall relationship: towards CHEBI:28793 ! beta-D-glucan created_by: midori creation_date: 2012-05-31T16:36:19Z [Term] id: FYPO:0001083 name: increased polysaccharide level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of a polysaccharide measured in a cell is greater than normal." [PomBase:mah] synonym: "increased cellular polysaccharide level" EXACT [PomBase:mah] synonym: "increased polysaccharide accumulation" RELATED [PomBase:mah] synonym: "increased polysaccharide level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased polysaccharide level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001085 ! altered polysaccharide level is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:18154 ! polysaccharide relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:18154 ! polysaccharide created_by: midori creation_date: 2012-05-31T16:37:01Z [Term] id: FYPO:0001084 name: increased cell wall alpha-glucan level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of alpha-D-glucan measured in the cell wall is greater than normal." [PomBase:mah] synonym: "increased cell wall alpha-D-glucan level" EXACT [CHEBI:22385, PomBase:mah] synonym: "increased cell wall alpha-glucan accumulation" RELATED [PomBase:mah] synonym: "increased cell wall alpha-glucan level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cell wall alpha-glucan level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001083 ! increased polysaccharide level is_a: FYPO:0002627 ! altered level of substance in cell wall intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0009277 ! fungal-type cell wall intersection_of: towards CHEBI:22385 ! alpha-D-glucan relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0009277 ! fungal-type cell wall relationship: towards CHEBI:22385 ! alpha-D-glucan created_by: midori creation_date: 2012-05-31T16:37:12Z [Term] id: FYPO:0001085 name: altered polysaccharide level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of a polysaccharide measured in a cell differs from normal." [PomBase:mah] synonym: "abnormal polysaccharide level" EXACT [PomBase:mah] synonym: "altered cellular polysaccharide level" EXACT [PomBase:mah] synonym: "altered polysaccharide level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "altered polysaccharide level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001323 ! altered level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:18154 ! polysaccharide relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:18154 ! polysaccharide created_by: midori creation_date: 2012-05-31T16:39:05Z [Term] id: FYPO:0001086 name: normal glucosyltransferase activity def: "A molecular function phenotype in which the observed rate of a glucosyltransferase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0046527 ! glucosyltransferase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0046527 ! glucosyltransferase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-05-31T16:41:20Z [Term] id: FYPO:0001087 name: abnormal glucosyltransferase activity def: "A molecular function phenotype in which the observed rate of a glucosyltransferase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0046527 ! glucosyltransferase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0046527 ! glucosyltransferase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-05-31T16:41:54Z [Term] id: FYPO:0001088 name: decreased glucosyltransferase activity def: "A molecular function phenotype in which the observed rate of a glucosyltransferase activity is decreased." [PomBase:mah] synonym: "reduced glucosyltransferase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0001087 ! abnormal glucosyltransferase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0046527 ! glucosyltransferase activity relationship: inheres_in GO:0046527 ! glucosyltransferase activity created_by: midori creation_date: 2012-05-31T16:42:14Z [Term] id: FYPO:0001089 name: increased glucosyltransferase activity def: "A molecular function phenotype in which the observed rate of a glucosyltransferase activity is increased." [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0001087 ! abnormal glucosyltransferase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0046527 ! glucosyltransferase activity relationship: inheres_in GO:0046527 ! glucosyltransferase activity created_by: midori creation_date: 2012-05-31T16:42:35Z [Term] id: FYPO:0001090 name: resistance to heat shock during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which cells show decreased sensitivity to heat shock. Heat shock is a form of heat stress in which cells are briefly exposed to a very high temperature." [PomBase:mah] synonym: "resistance to heat shock during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistant to heat shock during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000850 ! resistance to stress during vegetative growth is_a: FYPO:0002045 ! resistance to heat shock created_by: midori creation_date: 2012-06-01T13:48:51Z [Term] id: FYPO:0001091 name: normal cellular response to heat shock def: "A cellular response phenotype observed in the vegetative growth phase of the life cycle in which the cellular response to heat shock is normal (i.e. indistinguishable from wild type). Heat shock is a form of heat stress in which cells are briefly exposed to a very high temperature." [PomBase:mah] synonym: "normal cellular response to heat shock during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular response to heat shock during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000968 ! normal cellular response to stress created_by: midori creation_date: 2012-06-01T13:59:10Z [Term] id: FYPO:0001092 name: binding phenotype def: "A phenotype that affects the binding of a gene product to another substance. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast binding phenotype" EXACT [PomBase:mah] is_a: FYPO:0000652 ! molecular function phenotype intersection_of: FYPO:0000001 ! phenotype intersection_of: inheres_in GO:0005488 ! binding relationship: inheres_in GO:0005488 ! binding created_by: midori creation_date: 2012-06-01T14:07:32Z [Term] id: FYPO:0001093 name: abolished chromatin binding def: "A molecular function phenotype in which chromatin binding by a gene product (usually a protein) in a mutant does not occur. The affected gene product may be encoded by the mutated gene, or by a different gene, and may normally bind DNA, protein, or both in chromatin." [PomBase:mah] synonym: "abolished chromatin association" EXACT [PomBase:vw] synonym: "chromatin binding abolished" EXACT [PomBase:mah] is_a: FYPO:0002576 ! abnormal chromatin binding is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0003682 ! chromatin binding relationship: towards GO:0003682 ! chromatin binding created_by: midori creation_date: 2012-06-01T14:08:25Z [Term] id: FYPO:0001094 name: normal DNA replication origin binding def: "A molecular function phenotype in which occurrence of DNA binding at a replication origin by a gene product is normal (i.e. indistinguishable from wild type). The relevant gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "normal origin binding" EXACT [PomBase:mah] is_a: FYPO:0000655 ! normal DNA binding intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0003688 ! DNA replication origin binding intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0003688 ! DNA replication origin binding relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-06-01T14:23:10Z [Term] id: FYPO:0001095 name: abolished DNA replication origin binding def: "A molecular function phenotype in which DNA binding at a replication origin by a gene product does not occur, when a gene or the bound DNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "abolished origin binding" EXACT [PomBase:mah] synonym: "DNA replication origin binding abolished" EXACT [PomBase:mah] is_a: FYPO:0000659 ! abolished DNA binding intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0003688 ! DNA replication origin binding relationship: towards GO:0003688 ! DNA replication origin binding created_by: midori creation_date: 2012-06-01T14:24:32Z [Term] id: FYPO:0001096 name: normal RNA level during nitrogen starvation def: "A cell phenotype in which the amount of RNA measured in a cell that is subject to nitrogen starvation is normal (i.e. indistinguishable from wild type). Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "normal cellular RNA level during nitrogen starvation" EXACT [PomBase:mah] synonym: "normal mRNA level during nitrogen starvation" NARROW [PomBase:mah] synonym: "normal RNA accumulation during nitrogen starvation" RELATED [PomBase:mah] synonym: "normal RNA level during nitrogen depletion" EXACT [PomBase:vw] synonym: "normal RNA level during nitrogen deprivation" EXACT [PomBase:vw] is_a: FYPO:0000840 ! normal RNA level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in CL:0000000 ! cell intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in CL:0000000 ! cell relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2012-06-01T14:32:55Z [Term] id: FYPO:0001097 name: sensitive to amitrole def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to amitrole. Cells stop growing (and may die) at a concentration of amitrole that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to amitrole" EXACT [PomBase:mah] synonym: "sensitive to 3-amino-1,2,4-triazole" EXACT [CHEBI:40036, PomBase:al] synonym: "sensitive to amitrole during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to amitrole during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:40036 ! amitrole relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:40036 ! amitrole created_by: midori creation_date: 2012-06-01T14:35:59Z [Term] id: FYPO:0001098 name: sensitive to 4-nitroquinoline N-oxide def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to 4-nitroquinoline N-oxide. Cells stop growing (and may die) at a concentration of 4-nitroquinoline N-oxide that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to 4-nitroquinoline N-oxide" EXACT [PomBase:mah] synonym: "sensitive to 4-nitroquinoline N-oxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to 4-nitroquinoline N-oxide during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to 4-NQO" EXACT [PomBase:mah] synonym: "sensitive to 4NQO" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:16907 ! 4-nitroquinoline N-oxide relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:16907 ! 4-nitroquinoline N-oxide created_by: midori creation_date: 2012-06-01T14:37:39Z [Term] id: FYPO:0001099 name: normal growth on CCCP def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing carbonyl cyanide m-chlorophenyl hydrazone (CCCP)." [PomBase:mah] synonym: "normal cell population growth in presence of CCCP" EXACT [PomBase:mah] synonym: "normal cell population growth on carbonyl cyanide m-chlorophenyl hydrazone" EXACT [CHEBI:3259] synonym: "normal cell population growth on CCCP" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to CCCP" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on CCCP" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:3259 ! CCCP relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:3259 ! CCCP created_by: midori creation_date: 2012-06-01T14:38:51Z [Term] id: FYPO:0001100 name: normal growth on Gentian violet def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing Gentian violet (also known as crystal violet)." [PomBase:mah] synonym: "normal cell population growth in presence of Gentian violet" EXACT [PomBase:mah] synonym: "normal cell population growth on crystal violet" EXACT [PomBase:mah] synonym: "normal cell population growth on Gentian violet" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cell population growth on {4-[Bis-(4-dimethylamino-phenyl)-methylene]-cyclohexa-2,5-dienylidene}-dimethyl-ammonium chloride" EXACT [CHEBI:41688] synonym: "normal vegetative cell population growth on Gentian violet" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:41688 ! crystal violet relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:41688 ! crystal violet created_by: midori creation_date: 2012-06-01T14:39:48Z [Term] id: FYPO:0001101 name: decreased protein level during cellular response to hydrogen peroxide def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during a cellular response to hydrogen peroxide is lower than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein accumulation during cellular response to hydrogen peroxide" RELATED [PomBase:mah] synonym: "decreased protein level during cellular response to H2O2" EXACT [PomBase:mah] synonym: "decreased protein level during cellular response to hydrogen peroxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein level during cellular response to hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein level during cellular response to hydrogen peroxide" EXACT [PomBase:mah] is_a: FYPO:0001324 ! decreased protein level during vegetative growth is_a: FYPO:0001548 ! altered protein level during cellular response to hydrogen peroxide intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0070301 ! cellular response to hydrogen peroxide intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0070301 ! cellular response to hydrogen peroxide relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2012-06-01T14:47:37Z [Term] id: FYPO:0001102 name: increased protein level during cellular response to hydrogen peroxide def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during a cellular response to hydrogen peroxide is higher than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein accumulation during cellular response to hydrogen peroxide" RELATED [PomBase:mah] synonym: "increased protein level during cellular response to H2O2" EXACT [PomBase:mah] synonym: "increased protein level during cellular response to hydrogen peroxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein level during cellular response to hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001327 ! increased protein level during vegetative growth is_a: FYPO:0001548 ! altered protein level during cellular response to hydrogen peroxide intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0070301 ! cellular response to hydrogen peroxide intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0070301 ! cellular response to hydrogen peroxide relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2012-06-01T14:48:16Z [Term] id: FYPO:0001103 name: resistance to hydrogen peroxide def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of hydrogen peroxide than normal." [PomBase:mah] synonym: "resistance to H2O2" EXACT [CHEBI:16240, PomBase:mah] synonym: "resistance to hydrogen peroxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to hydrogen peroxide" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:16240 ! hydrogen peroxide relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:16240 ! hydrogen peroxide created_by: midori creation_date: 2012-06-01T14:49:59Z [Term] id: FYPO:0001104 name: abnormal catalase activity def: "A molecular function phenotype in which the observed rate of catalase activity is abnormal." [PomBase:mah] is_a: FYPO:0000689 ! abnormal oxidoreductase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004096 ! catalase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004096 ! catalase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-06-01T15:00:27Z [Term] id: FYPO:0001105 name: abolished catalase activity def: "A molecular function phenotype in which catalase activity is absent." [PomBase:mah] synonym: "catalase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0001104 ! abnormal catalase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0004096 ! catalase activity relationship: towards GO:0004096 ! catalase activity created_by: midori creation_date: 2012-06-01T15:00:35Z [Term] id: FYPO:0001106 name: abnormal glutathione-disulfide reductase activity def: "A molecular function phenotype in which the observed rate of glutathione-disulfide reductase activity is abnormal." [PomBase:mah] synonym: "abnormal glutathione-disulphide reductase activity" EXACT [PomBase:mah] is_a: FYPO:0003963 ! abnormal glutathione disulfide oxidoreductase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004362 ! glutathione-disulfide reductase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004362 ! glutathione-disulfide reductase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-06-01T15:14:45Z [Term] id: FYPO:0001107 name: decreased glutathione-disulfide reductase activity def: "A molecular function phenotype in which the observed rate of glutathione-disulfide reductase activity is decreased." [PomBase:mah] synonym: "decreased glutathione-disulphide reductase activity" EXACT [PomBase:mah] synonym: "reduced glutathione-disulfide reductase activity" EXACT [PomBase:mah] is_a: FYPO:0001106 ! abnormal glutathione-disulfide reductase activity is_a: FYPO:0003964 ! decreased glutathione disulfide oxidoreductase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004362 ! glutathione-disulfide reductase activity relationship: inheres_in GO:0004362 ! glutathione-disulfide reductase activity created_by: midori creation_date: 2012-06-01T15:14:58Z [Term] id: FYPO:0001108 name: increased glutathione-disulfide reductase activity def: "A molecular function phenotype in which the observed rate of glutathione-disulfide reductase activity is increased." [PomBase:mah] synonym: "increased glutathione-disulphide reductase activity" EXACT [PomBase:mah] is_a: FYPO:0001106 ! abnormal glutathione-disulfide reductase activity is_a: FYPO:0003965 ! increased glutathione disulfide oxidoreductase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0004362 ! glutathione-disulfide reductase activity relationship: inheres_in GO:0004362 ! glutathione-disulfide reductase activity created_by: midori creation_date: 2012-06-01T15:15:04Z [Term] id: FYPO:0001109 name: resistance to menadione def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of menadione than normal." [PomBase:mah] synonym: "resistance to menadione during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to menadione during vegetative growth" EXACT [PomBase:mah] synonym: "resistance to vitamin K3" RELATED [PomBase:al] synonym: "resistant to menadione" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:28869 ! menadione relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:28869 ! menadione created_by: midori creation_date: 2012-06-01T15:18:55Z [Term] id: FYPO:0001110 name: inviable after spore germination, multiple cell divisions, normal morphology def: "A phenotype in which a spore germinates to produce a cell of normal morphology (i.e. size, shape, and structure) that undergoes two or more rounds of cell division, and then dies." [PomBase:al, PomBase:mah] synonym: "essential; germinating spore, multiple cell divisions, normal morphology" RELATED [PomBase:mah] synonym: "inviable following spore germination, multiple cell divisions, normal morphology" EXACT [PomBase:mah] synonym: "inviable germinated spore, multiple cell divisions, normal morphology" EXACT [PomBase:mah] is_a: FYPO:0002430 ! inviable after spore germination, multiple cell divisions created_by: midori creation_date: 2012-06-01T15:21:23Z [Term] id: FYPO:0001111 name: increased cellular glutathione disulfide level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of glutathione disulfide (GSSG) measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular glutathione disulfide level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular glutathione disulfide level during vegetative growth" EXACT [PomBase:mah] synonym: "increased cellular glutathione disulphide level" EXACT [PomBase:mah] synonym: "increased cellular GSSG level" EXACT [CHEBI:17858, PomBase:al] synonym: "increased cellular oxidised glutathione level" EXACT [CHEBI:17858, PomBase:al] synonym: "increased glutathione disulfide accumulation" RELATED [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:17858 ! glutathione disulfide relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:17858 ! glutathione disulfide created_by: midori creation_date: 2012-06-01T15:26:21Z [Term] id: FYPO:0001112 name: advanced cell cycle arrest in mitotic G1 phase in response to nitrogen starvation def: "A cellular process phenotype in which the occurrence of cell cycle arrest in response to nitrogen starvation occurs in G1 phase, but begins earlier than normal." [PomBase:mah] synonym: "advanced cell cycle arrest in mitotic G1 phase during cellular response to nitrogen starvation" EXACT [PomBase:mah] synonym: "advanced cell cycle arrest in mitotic G1 phase in response to nitrogen depletion" EXACT [PomBase:vw] synonym: "advanced cell cycle arrest in mitotic G1 phase in response to nitrogen deprivation" EXACT [PomBase:vw] synonym: "advanced mitotic cell cycle arrest in G1 phase in response to nitrogen starvation" EXACT [PomBase:mah] synonym: "advanced mitotic G1 arrest in response to nitrogen starvation" EXACT [PomBase:mah] synonym: "advanced nitrogen deprivation-induced G1 arrest" EXACT [PomBase:vw] synonym: "premature cell cycle arrest in mitotic G1 phase in response to nitrogen starvation" EXACT [PomBase:mah] is_a: FYPO:0000445 ! cell cycle arrest in mitotic G1 phase is_a: FYPO:0000710 ! abnormal mitotic cell cycle arrest in response to nitrogen starvation is_a: PATO:0000694 ! premature intersection_of: PATO:0000694 ! premature intersection_of: during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in GO:0030996 ! mitotic cell cycle arrest in response to nitrogen starvation relationship: during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in GO:0030996 ! mitotic cell cycle arrest in response to nitrogen starvation created_by: midori creation_date: 2012-06-01T15:29:57Z [Term] id: FYPO:0001113 name: normal cellular response to pheromone def: "A cellular response phenotype in which the cellular response to a pheromone is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000953 ! normal cellular response to chemical stimulus intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0071444 ! cellular response to pheromone intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0071444 ! cellular response to pheromone relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-06-01T15:37:34Z [Term] id: FYPO:0001114 name: normal cellular response to M-factor def: "A cellular response phenotype in which the cellular response to M-factor is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0001113 ! normal cellular response to pheromone intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0071444 ! cellular response to pheromone intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:64120 ! M-factor relationship: inheres_in GO:0071444 ! cellular response to pheromone relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:64120 ! M-factor created_by: midori creation_date: 2012-06-01T15:39:05Z [Term] id: FYPO:0001115 name: normal cellular response to P-factor def: "A cellular response phenotype in which the cellular response to P-factor is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0001113 ! normal cellular response to pheromone intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0071444 ! cellular response to pheromone intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:64121 ! P-factor relationship: inheres_in GO:0071444 ! cellular response to pheromone relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:64121 ! P-factor created_by: midori creation_date: 2012-06-01T15:39:33Z [Term] id: FYPO:0001116 name: decreased RNA level during cellular response to hydrogen peroxide def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to hydrogen peroxide is lower than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased mRNA level during cellular response to hydrogen peroxide" NARROW [PomBase:mah] synonym: "decreased RNA accumulation during cellular response to hydrogen peroxide" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to H2O2" EXACT [PomBase:mah] synonym: "decreased RNA level during cellular response to hydrogen peroxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] synonym: "decreased transcript level during cellular response to hydrogen peroxide" EXACT [PomBase:vw] synonym: "reduced RNA level during cellular response to hydrogen peroxide" EXACT [PomBase:mah] is_a: FYPO:0001280 ! decreased RNA level during cellular response to oxidative stress intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0070301 ! cellular response to hydrogen peroxide intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0070301 ! cellular response to hydrogen peroxide relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2012-06-07T11:25:57Z [Term] id: FYPO:0001117 name: decreased RNA level during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell is lower than normal. Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased cellular RNA level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased RNA accumulation during vegetative growth" RELATED [PomBase:mah] synonym: "decreased RNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased transcript level during vegetative growth" EXACT [PomBase:vw] synonym: "reduced RNA level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000826 ! decreased RNA level is_a: FYPO:0001326 ! altered RNA level during vegetative growth is_a: FYPO:0001329 ! decreased level of substance in cell during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2012-06-07T11:31:36Z [Term] id: FYPO:0001118 name: abnormal vegetative cell morphology def: "A cell phenotype in which cell morphology (i.e. the size, shape, or structure of the cell) is altered in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "abnormal cell morphology during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal vegetative cell morphology during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000005 ! abnormal cell morphology is_a: FYPO:0004639 ! abnormal cellular physical quality phenotype during vegetative growth intersection_of: FYPO:0000005 ! abnormal cell morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase created_by: midori creation_date: 2012-06-07T11:45:38Z [Term] id: FYPO:0001119 name: tapered vegetative cell def: "A cell morphology phenotype in which the cell tapers at one end to a diameter smaller than the other in the vegetative growth phase of the life cycle. The cell diameter at the narrow end is smaller than that of a wild-type cell." [PomBase:mah] synonym: "bottle-shaped vegetative cell" EXACT [PomBase:vw] synonym: "bottle-shaped vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "cell morphology, bottle/skittle during vegetative growth" EXACT [PomBase:mah] synonym: "skittle-shaped cell during vegetative growth" EXACT [PomBase:mah] synonym: "tapered cell during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000014 ! tapered cell is_a: FYPO:0002196 ! abnormal vegetative cell shape intersection_of: FYPO:0000014 ! tapered cell intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase created_by: midori creation_date: 2012-06-07T11:47:07Z [Term] id: FYPO:0001120 name: pear-shaped vegetative cell def: "A cell morphology phenotype in which a cell is shaped in the form of a pear in the vegetative growth phase of the life cycle. One end is rounded, while the other resembles an end of a normal rod-shaped cell. The normally shaped end has the same diameter as a wild-type cell." [PomBase:mah] synonym: "cell morphology, pear shaped during vegetative growth" EXACT [PomBase:mah] synonym: "ice cream cone-shaped cell during vegetative growth" EXACT [PMID:2236039, PomBase:vw] synonym: "pear-shaped cell during vegetative growth" EXACT [PomBase:mah] synonym: "pear-shaped vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000020 ! pear-shaped cell is_a: FYPO:0002196 ! abnormal vegetative cell shape intersection_of: FYPO:0000020 ! pear-shaped cell intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase created_by: midori creation_date: 2012-06-07T11:47:18Z [Term] id: FYPO:0001121 name: vegetative cell, abnormal cell shape, normal cell size def: "A cell phenotype in which cell shape is altered, but cell size remains normal, in the vegetative growth phase of the life cycle." [PomBase:mah, PomBase:vw] synonym: "abnormal cell shape, normal cell size during vegetative growth" EXACT [PomBase:mah] synonym: "lumpy" RELATED [PomBase:vw] synonym: "vegetative cell, abnormal cell shape, normal cell size during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0001124 ! normal vegetative cell size intersection_of: has_part FYPO:0001126 ! abnormal cell shape relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0001124 ! normal vegetative cell size relationship: has_part FYPO:0001126 ! abnormal cell shape created_by: midori creation_date: 2012-06-07T11:56:50Z [Term] id: FYPO:0001122 name: elongated vegetative cell def: "A cell phenotype in which a cell is elongated in the vegetative growth phase of the life cycle." [PomBase:mah] comment: Note that this term is classified as a type of abnormal cell shape, because wild-type cells are never seen with the proportions (length:width ratio) observed in elongated cells. Small cells, in contrast, have the same proportions as a subset of wild-type cells, and simply do not grow to the full length seen in wild type. synonym: "long vegetative cell" EXACT [PomBase:vw] is_a: FYPO:0000017 ! elongated cell is_a: FYPO:0002196 ! abnormal vegetative cell shape intersection_of: FYPO:0000017 ! elongated cell intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase created_by: midori creation_date: 2012-06-07T13:10:57Z [Term] id: FYPO:0001123 name: elongated spore def: "A cell phenotype in which a spore is longer than normal." [PomBase:mah] comment: Note that this term is classified as a type of abnormal cell shape, because wild-type cells are never seen with the proportions (length:width ratio) observed in elongated cells. Small cells, in contrast, have the same proportions as a subset of wild-type cells, and simply do not grow to the full length seen in wild type. synonym: "long spores" EXACT [PomBase:vw] is_a: FYPO:0000017 ! elongated cell is_a: FYPO:0002467 ! abnormal spore shape intersection_of: PATO:0000573 ! increased length intersection_of: inheres_in CL:0000596 ! sexual spore relationship: inheres_in CL:0000596 ! sexual spore created_by: midori creation_date: 2012-06-07T13:11:48Z [Term] id: FYPO:0001124 name: normal vegetative cell size def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell has normal volume and dimensions." [PomBase:mah] synonym: "normal cell size during vegetative growth" EXACT [PomBase:mah] synonym: "normal vegetative cell size during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001315 ! normal vegetative cell morphology is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-06-07T15:28:36Z [Term] id: FYPO:0001125 name: normal vegetative cell shape def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell has a normal shape." [PomBase:mah] synonym: "normal cell shape during vegetative growth" EXACT [PomBase:mah] synonym: "normal vegetative cell shape during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001315 ! normal vegetative cell morphology is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-06-07T15:28:36Z [Term] id: FYPO:0001126 name: abnormal cell shape def: "A cell morphology phenotype in which a cell has an abnormal shape." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "misshapen cell" RELATED [PomBase:mah] is_a: FYPO:0000005 ! abnormal cell morphology is_a: PATO:0000052 ! shape intersection_of: PATO:0000052 ! shape intersection_of: inheres_in CL:0000000 ! cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in CL:0000000 ! cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-06-07T15:28:36Z [Term] id: FYPO:0001127 name: abnormal cell size def: "A cell morphology phenotype in which a cell has a volume or dimensions that differ from normal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate is_a: FYPO:0000005 ! abnormal cell morphology is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size intersection_of: inheres_in CL:0000000 ! cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in CL:0000000 ! cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-06-07T16:00:41Z [Term] id: FYPO:0001128 name: decreased septation index def: "A cell population phenotype in which the septation index is lower than normal. The septation index is the proportion of the population undergoing septation at any given time, and is usually around 10% (varying between 7-15%) for wild type." [PomBase:mah] synonym: "decreased septation" RELATED [PomBase:mah] synonym: "reduced septation index" EXACT [PomBase:mah] is_a: FYPO:0000003 ! cell population phenotype is_a: FYPO:0001985 ! abnormal phenotype created_by: midori creation_date: 2012-06-08T11:45:02Z [Term] id: FYPO:0001129 name: abnormal protein localization to nucleus during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleus is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found in the nucleus and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to nucleus during vegetative growth" EXACT [GO:0034504, PomBase:mah] synonym: "abnormal protein localization to nucleus during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000443 ! abnormal protein localization during vegetative growth is_a: FYPO:0002956 ! abnormal protein localization to nucleus intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0034504 ! protein localization to nucleus intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0034504 ! protein localization to nucleus relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-06-08T12:02:23Z [Term] id: FYPO:0001130 name: increased protein localization to nucleus during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleus is increased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to nucleus during vegetative growth" EXACT [GO:0034504, PomBase:mah] synonym: "increased protein localization to nucleus during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001129 ! abnormal protein localization to nucleus during vegetative growth is_a: FYPO:0004456 ! increased protein localization to nucleus intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034504 ! protein localization to nucleus relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034504 ! protein localization to nucleus created_by: midori creation_date: 2012-06-08T12:04:38Z [Term] id: FYPO:0001131 name: abnormal protein localization to heterochromatin during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to heterochromatin is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found associated with heterochromatin and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to heterochromatin during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal protein localization to heterochromatin during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000452 ! abnormal protein localization to chromatin during vegetative growth is_a: FYPO:0004718 ! abnormal protein localization to heterochromatin intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0097355 ! protein localization to heterochromatin intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0097355 ! protein localization to heterochromatin relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-06-08T15:14:15Z [Term] id: FYPO:0001132 name: abolished protein localization to heterochromatin during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to heterochromatin is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to heterochromatin during vegetative growth" EXACT [PomBase:mah] synonym: "abolished protein localization to heterochromatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein localization to heterochromatin abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001131 ! abnormal protein localization to heterochromatin during vegetative growth is_a: FYPO:0001508 ! abolished protein localization to chromatin during vegetative growth intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0097355 ! protein localization to heterochromatin relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0097355 ! protein localization to heterochromatin created_by: midori creation_date: 2012-06-08T15:15:02Z [Term] id: FYPO:0001133 name: normal DNA replication def: "A cellular process phenotype in which DNA replication is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal DNA replication during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal DNA replication during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000859 ! normal metabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006261 ! DNA-dependent DNA replication intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006261 ! DNA-dependent DNA replication relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-06-08T15:41:39Z [Term] id: FYPO:0001134 name: normal 18S rRNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of 18S ribosomal RNA measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal 18S rRNA accumulation" RELATED [PomBase:mah] synonym: "normal 18S rRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal 18S rRNA level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001317 ! normal RNA level during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards SO:0000407 ! rRNA_18S relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards SO:0000407 ! rRNA_18S created_by: midori creation_date: 2012-06-08T16:38:01Z [Term] id: FYPO:0001135 name: increased 35S rRNA precursor level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of the 35S rRNA primary transcript measured in a cell is higher than normal." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "increased 35S rRNA precursor accumulation" RELATED [PomBase:mah] synonym: "increased 35S rRNA precursor level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased 35S rRNA precursor level during vegetative growth" EXACT [PomBase:mah] synonym: "increased 35S rRNA precursor transcript level" EXACT [PomBase:vw] synonym: "increased 35S rRNA primary transcript level" EXACT [PomBase:mah, SO:0000325] is_a: FYPO:0003600 ! increased rRNA precursor level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards SO:0000325 ! rRNA_large_subunit_primary_transcript relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards SO:0000325 ! rRNA_large_subunit_primary_transcript created_by: midori creation_date: 2012-06-08T16:40:54Z [Term] id: FYPO:0001136 name: increased 27S rRNA precursor level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of any 27S rRNA precursor measured in a cell is higher than normal." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "increased 27S rRNA precursor accumulation" RELATED [PomBase:mah] synonym: "increased 27S rRNA precursor level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased 27S rRNA precursor level during vegetative growth" EXACT [PomBase:mah] synonym: "increased 27S rRNA precursor transcript level" EXACT [PomBase:vw] is_a: FYPO:0003600 ! increased rRNA precursor level created_by: midori creation_date: 2012-06-08T16:44:25Z [Term] id: FYPO:0001137 name: decreased 25S rRNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of the mature 25S rRNA measured in a cell is lower than normal." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "decreased 25S rRNA accumulation" RELATED [PomBase:mah] synonym: "decreased 25S rRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased 25S rRNA level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased 25S rRNA transcript level" EXACT [PomBase:vw] synonym: "decreased mature 25S rRNA transcript" EXACT [PomBase:vw] synonym: "reduced 25S rRNA level" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards SO:0001002 ! rRNA_25S relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards SO:0001002 ! rRNA_25S created_by: midori creation_date: 2012-06-08T16:45:47Z [Term] id: FYPO:0001138 name: decreased 5.8S rRNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of the mature 5.8S rRNA measured in a cell is lower than normal." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "decreased 5.8S rRNA accumulation" RELATED [PomBase:mah] synonym: "decreased 5.8S rRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased 5.8S rRNA level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased 5.8S rRNA transcript level" EXACT [PomBase:vw] synonym: "decreased mature 5.8S rRNA transcript" EXACT [PomBase:vw] synonym: "reduced 5.8S rRNA level" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards SO:0000375 ! rRNA_5_8S relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards SO:0000375 ! rRNA_5_8S created_by: midori creation_date: 2012-06-08T16:47:19Z [Term] id: FYPO:0001139 name: abnormal leucine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of leucine into the cell is abnormal." [PomBase:mah] synonym: "abnormal L-leucine import" EXACT [PomBase:mah] synonym: "abnormal leucine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal leucine import during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal leucine import into cell" EXACT [PomBase:al] synonym: "abnormal leucine uptake" EXACT [PomBase:mah] is_a: FYPO:0001361 ! abnormal amino acid import during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1903801 ! L-leucine import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1903801 ! L-leucine import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-06-11T14:24:42Z [Term] id: FYPO:0001140 name: decreased leucine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of leucine into the cell occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased L-leucine import" EXACT [PomBase:mah] synonym: "decreased leucine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased leucine import during vegetative growth" EXACT [PomBase:mah] synonym: "decreased leucine import into cell" EXACT [PomBase:al] synonym: "decreased leucine uptake" EXACT [PomBase:mah] synonym: "reduced leucine import" EXACT [PomBase:mah] is_a: FYPO:0001139 ! abnormal leucine import is_a: FYPO:0001360 ! decreased amino acid import during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903801 ! L-leucine import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903801 ! L-leucine import into cell created_by: midori creation_date: 2012-06-11T14:26:26Z [Term] id: FYPO:0001141 name: abolished transcriptional response to pheromone def: "A conjugation phenotype in which regulation of transcription in response to mating pheromone is abolished." [PomBase:mah] synonym: "abolished regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [GO:0046019, PomBase:mah] synonym: "transcriptional response to pheromone abolished" EXACT [PomBase:mah] is_a: FYPO:0000984 ! abnormal transcriptional response to pheromone is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0046019 ! regulation of transcription from RNA polymerase II promoter by pheromones relationship: towards GO:0046019 ! regulation of transcription from RNA polymerase II promoter by pheromones created_by: midori creation_date: 2012-06-11T14:48:00Z [Term] id: FYPO:0001142 name: normal Man8GlcNAc level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of Man8GlcNAc2 measured in a cell is normal (i.e. indistinguishable from wild type). Man8GlcNAc2 is any N-glycan that consists of a branched ten-membered mannooligosaccharide containing eight D-mannosyl residues and two N-acetylglucosamine residues." [CHEBI:64048, CHEBI:64052, PMID:12686557, PomBase:mah] comment: Note that these terms treat Man(n)GlcNAc and Man(n)GlcNAc2 as equivalent. The reason is that the GlcNAc2 form is attached to N-linked glycoproteins, but the GlcNAc form is what is usually detected in experiments, following cleavage by endoglycosidase H. For the purposes of observing and interpreting phenotypes, the difference is not significant. synonym: "normal cellular Man8GlcNAc level" EXACT [PomBase:al] synonym: "normal Man8GlcNAc accumulation" RELATED [PomBase:mah] synonym: "normal Man8GlcNAc level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal Man8GlcNAc level during vegetative growth" EXACT [PomBase:mah] synonym: "normal Man8GlcNAc2 level" EXACT [PomBase:mah] is_a: FYPO:0001077 ! normal polysaccharide level created_by: midori creation_date: 2012-06-14T15:52:46Z [Term] id: FYPO:0001143 name: normal Man9GlcNAc level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of Man9GlcNAc2 measured in a cell is normal (i.e. indistinguishable from wild type). Man9GlcNAc2 is any N-glycan that consists of a branched undecasaccharide consisting of nine D-mannosyl residues and two N-acetylglucosamine residues." [CHEBI:59579, PMID:12686557, PomBase:mah] comment: Note that these terms treat Man(n)GlcNAc and Man(n)GlcNAc2 as equivalent. The reason is that the GlcNAc2 form is attached to N-linked glycoproteins, but the GlcNAc form is what is usually detected in experiments, following cleavage by endoglycosidase H. For the purposes of observing and interpreting phenotypes, the difference is not significant. synonym: "normal cellular Man9GlcNAc level" EXACT [PomBase:al] synonym: "normal Man9GlcNAc accumulation" RELATED [PomBase:mah] synonym: "normal Man9GlcNAc level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal Man9GlcNAc level during vegetative growth" EXACT [PomBase:mah] synonym: "normal Man9GlcNAc2 level" EXACT [PomBase:mah] is_a: FYPO:0001077 ! normal polysaccharide level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:59579 ! alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:59579 ! alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc created_by: midori creation_date: 2012-06-14T15:55:35Z [Term] id: FYPO:0001144 name: decreased Man8GlcNAc level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of Man8GlcNAc2 measured in a cell is lower than normal. Man8GlcNAc2 is any N-glycan that consists of a branched ten-membered mannooligosaccharide containing eight D-mannosyl residues and two N-acetylglucosamine residues." [CHEBI:64048, CHEBI:64052, PMID:12686557, PomBase:mah] comment: Note that these terms treat Man(n)GlcNAc and Man(n)GlcNAc2 as equivalent. The reason is that the GlcNAc2 form is attached to N-linked glycoproteins, but the GlcNAc form is what is usually detected in experiments, following cleavage by endoglycosidase H. For the purposes of observing and interpreting phenotypes, the difference is not significant. synonym: "decreased cellular Man8GlcNAc level" EXACT [PomBase:al] synonym: "decreased Man8GlcNAc accumulation" RELATED [PomBase:mah] synonym: "decreased Man8GlcNAc level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased Man8GlcNAc level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased Man8GlcNAc2 level" EXACT [PomBase:mah] synonym: "reduced Man8GlcNAc level" EXACT [PomBase:mah] is_a: FYPO:0001080 ! decreased polysaccharide level created_by: midori creation_date: 2012-06-14T15:59:43Z [Term] id: FYPO:0001145 name: increased Man9GlcNAc level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of Man9GlcNAc2 measured in a cell is higher than normal. Man9GlcNAc2 is any N-glycan that consists of a branched undecasaccharide consisting of nine D-mannosyl residues and two N-acetylglucosamine residues." [CHEBI:59579, PMID:12686557, PomBase:mah] comment: Note that these terms treat Man(n)GlcNAc and Man(n)GlcNAc2 as equivalent. The reason is that the GlcNAc2 form is attached to N-linked glycoproteins, but the GlcNAc form is what is usually detected in experiments, following cleavage by endoglycosidase H. For the purposes of observing and interpreting phenotypes, the difference is not significant. synonym: "increased cellular Man9GlcNAc level" EXACT [PomBase:al] synonym: "increased Man9GlcNAc accumulation" RELATED [PomBase:mah] synonym: "increased Man9GlcNAc level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased Man9GlcNAc level during vegetative growth" EXACT [PomBase:mah] synonym: "increased Man9GlcNAc2 level" EXACT [PomBase:mah] is_a: FYPO:0001083 ! increased polysaccharide level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:59579 ! alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:59579 ! alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc created_by: midori creation_date: 2012-06-14T16:00:30Z [Term] id: FYPO:0001146 name: decreased misfolded glycoprotein degradation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of misfolded glycoprotein degradation is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased misfolded glycoprotein catabolic process" EXACT [GO:0030163, PomBase:mah] synonym: "decreased misfolded glycoprotein catabolism" EXACT [PomBase:mah] synonym: "decreased misfolded glycoprotein degradation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased misfolded glycoprotein degradation during vegetative growth" EXACT [PomBase:mah] synonym: "reduced misfolded glycoprotein degradation" EXACT [PomBase:mah] is_a: FYPO:0000846 ! decreased protein degradation during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0097466 ! glycoprotein ERAD pathway relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0097466 ! glycoprotein ERAD pathway created_by: midori creation_date: 2012-06-14T16:04:32Z [Term] id: FYPO:0001147 name: normal mating efficiency def: "A biological process phenotype in which the observed mating efficiency is normal (i.e. the same as in wild-type cells)." [PomBase:al, PomBase:mah] comment: Note that mating efficiency is often measured by counting zygotes plus asci, sometimes also including spores, so a change in measured mating efficiency may reflect a change in conjugation frequency (see FYPO:0000031 and its descendants), a change in sporulation (see FYPO:0000121 and its descendants), or both. For this reason, this term is not a child of 'mating phenotype' (FYPO:0000031). is_a: FYPO:0000003 ! cell population phenotype is_a: FYPO:0000257 ! normal phenotype created_by: midori creation_date: 2012-06-14T16:21:22Z [Term] id: FYPO:0001148 name: normal growth on amiloride def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing amiloride." [PomBase:mah] synonym: "normal cell population growth in presence of amiloride" EXACT [PomBase:mah] synonym: "normal cell population growth on amiloride" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to amiloride" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on amiloride" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:2639 ! amiloride relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:2639 ! amiloride created_by: midori creation_date: 2012-06-14T16:30:50Z [Term] id: FYPO:0001149 name: normal growth on methylamine def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing methylamine." [PomBase:mah] synonym: "normal cell population growth in presence of methylamine" EXACT [PomBase:mah] synonym: "normal cell population growth on methylamine" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to methylamine" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on methylamine" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:16830 ! methylamine relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:16830 ! methylamine created_by: midori creation_date: 2012-06-14T16:33:06Z [Term] id: FYPO:0001150 name: sensitive to methylamine def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to methylamine. Cells stop growing (and may die) at a concentration of methylamine that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to methylamine" EXACT [PomBase:mah] synonym: "sensitive to methylamine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to methylamine during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:16830 ! methylamine relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:16830 ! methylamine created_by: midori creation_date: 2012-06-14T16:34:29Z [Term] id: FYPO:0001151 name: cell cycle arrest in mitotic G2 phase during starvation def: "A cellular process phenotype in which progression through the mitotic cell cycle is arrested in G2 phase when the cell is subject to starvation for one or more nutrients." [PMID:19366728, PomBase:mah] synonym: "cell cycle arrest in mitotic G2 phase during depletion" EXACT [PomBase:vw] synonym: "cell cycle arrest in mitotic G2 phase during deprivation" EXACT [PomBase:vw] synonym: "mitotic cell cycle arrest in G2 phase during starvation" EXACT [PomBase:mah] synonym: "mitotic G2 phase arrest during starvation" EXACT [PomBase:mah] is_a: FYPO:0000446 ! cell cycle arrest in mitotic G2 phase intersection_of: during GO:0000085 ! mitotic G2 phase intersection_of: during GO:0009267 ! cellular response to starvation intersection_of: inheres_in GO:0071850 ! mitotic cell cycle arrest intersection_of: qualifier PATO:0000467 ! present relationship: during GO:0000085 ! mitotic G2 phase relationship: during GO:0009267 ! cellular response to starvation relationship: inheres_in GO:0071850 ! mitotic cell cycle arrest relationship: qualifier PATO:0000467 ! present created_by: midori creation_date: 2012-06-14T16:45:50Z [Term] id: FYPO:0001152 name: decreased RNA level during nitrogen starvation def: "A cell phenotype in which the amount of RNA measured in a cell when the cell is subject to nitrogen starvation is lower than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased RNA accumulation during nitrogen starvation" RELATED [PomBase:mah] synonym: "decreased RNA level during nitrogen depletion" EXACT [PomBase:vw] synonym: "decreased RNA level during nitrogen deprivation" EXACT [PomBase:vw] synonym: "decreased transcript level during nitrogen starvation" EXACT [PomBase:vw] synonym: "reduced RNA level during nitrogen starvation" EXACT [PomBase:mah] is_a: FYPO:0000826 ! decreased RNA level is_a: FYPO:0004139 ! altered level of substance in cell during nitrogen starvation intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2012-06-14T16:52:51Z [Term] id: FYPO:0001153 name: normal cellular methylamine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of methylamine measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular methylamine accumulation" RELATED [PomBase:mah] synonym: "normal cellular methylamine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular methylamine level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:16830 ! methylamine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:16830 ! methylamine created_by: midori creation_date: 2012-06-14T16:54:23Z [Term] id: FYPO:0001154 name: increased cellular methylamine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of methylamine measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular methylamine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular methylamine level during vegetative growth" EXACT [PomBase:mah] synonym: "increased methylamine accumulation" RELATED [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:16830 ! methylamine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:16830 ! methylamine created_by: midori creation_date: 2012-06-14T16:55:28Z [Term] id: FYPO:0001155 name: altered effect on growth medium def: "A phenotype in which the changes that take place in growth medium, due to metabolism, secretion, etc. by a cell or population of cells, differs from normal." [PomBase:mah] synonym: "abnormal effect on growth medium" EXACT [PomBase:mah] is_a: FYPO:0001985 ! abnormal phenotype created_by: midori creation_date: 2012-06-15T12:57:29Z [Term] id: FYPO:0001156 name: decreased pH of growth medium def: "A phenotype in which cells cause the pH of their growth medium to decrease by a greater amount than normal." [PomBase:mah] synonym: "decreased pH level of growth medium" EXACT [PomBase:al] synonym: "increased growth medium acidification" EXACT [PMID:10467002, PomBase:mah] synonym: "reduced pH of growth medium" EXACT [PomBase:mah] is_a: FYPO:0001155 ! altered effect on growth medium created_by: midori creation_date: 2012-06-15T13:37:06Z [Term] id: FYPO:0001157 name: increased cell population growth rate at high pH def: "A cell population phenotype in which a cell population in the vegetative growth phase of the life cycle grows at a faster rate than normal in a medium with higher than standard pH. Standard S. pombe growth media are approximately pH 5.6." [PMID:10467002, PomBase:mah] comment: Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "enhanced growth at high pH" RELATED [PomBase:mah] synonym: "fast cell population growth at high pH" EXACT [PomBase:mah] synonym: "increased cell population growth rate at high pH during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cell population growth rate at high pH during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000636 ! increased cell population growth rate created_by: midori creation_date: 2012-06-15T13:43:25Z [Term] id: FYPO:0001158 name: normal cellular pH def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the measured intracellular pH is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular pH during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular pH during vegetative growth" EXACT [PomBase:mah] synonym: "normal cellular pH level" EXACT [PomBase:al] is_a: FYPO:0001312 ! normal vegetative phenotype is_a: FYPO:0001320 ! vegetative cell phenotype created_by: midori creation_date: 2012-06-15T13:47:22Z [Term] id: FYPO:0001159 name: increased cellular pH def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the measured intracellular pH is higher than normal." [PomBase:mah] synonym: "increased cellular pH during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular pH during vegetative growth" EXACT [PomBase:mah] synonym: "increased cellular pH level" EXACT [PomBase:al] is_a: FYPO:0001320 ! vegetative cell phenotype is_a: FYPO:0003037 ! abnormal cell phenotype created_by: midori creation_date: 2012-06-15T13:47:43Z [Term] id: FYPO:0001160 name: cell cycle arrest in mitotic G2 phase during stationary phase def: "A cellular process phenotype in which progression through the mitotic cell cycle is arrested in G2 phase when the population in which the cell is found is in stationary phase." [PMID:19366728, PomBase:mah] synonym: "mitotic cell cycle arrest in G2 phase during stationary phase" EXACT [PomBase:mah] synonym: "mitotic G2 phase arrest during stationary phase" EXACT [PomBase:mah] is_a: FYPO:0000446 ! cell cycle arrest in mitotic G2 phase intersection_of: during GO:0000085 ! mitotic G2 phase intersection_of: during GO:0060274 ! maintenance of stationary phase intersection_of: inheres_in GO:0071850 ! mitotic cell cycle arrest intersection_of: qualifier PATO:0000467 ! present relationship: during GO:0000085 ! mitotic G2 phase relationship: during GO:0060274 ! maintenance of stationary phase relationship: inheres_in GO:0071850 ! mitotic cell cycle arrest relationship: qualifier PATO:0000467 ! present created_by: midori creation_date: 2012-06-15T14:04:54Z [Term] id: FYPO:0001162 name: decreased cell population growth on raffinose carbon source def: "A vegetative cell population growth phenotype in which cell growth is decreased relative to normal under aerobic conditions and in a medium containing raffinose as the carbon source." [PomBase:mah] comment: Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "decreased aerobic cell growth on raffinose carbon source" NARROW [PomBase:mah] synonym: "decreased growth on raffinose carbon source" BROAD [PomBase:mah] synonym: "decreased vegetative cell growth on raffinose carbon source" EXACT [PomBase:mah] synonym: "reduced cell growth on raffinose carbon source" EXACT [PomBase:mah] synonym: "slow aerobic cell growth on raffinose carbon source" NARROW [PomBase:mah] is_a: FYPO:0001355 ! decreased vegetative cell population growth intersection_of: FYPO:0000046 ! decreased cell population growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:16634 ! raffinose relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:16634 ! raffinose created_by: midori creation_date: 2012-06-15T14:21:23Z [Term] id: FYPO:0001164 name: normal growth on glucose carbon source def: "A vegetative cell population growth phenotype in which cells grow normally in a medium containing glucose as the carbon source." [PomBase:mah] synonym: "normal cell population growth on glucose carbon source" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal vegetative cell population growth on dextrose carbon source" EXACT [PomBase:al] synonym: "normal vegetative cell population growth on glucose carbon source" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0000047 ! normal cell population growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:17634 ! D-glucose relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:17634 ! D-glucose created_by: midori creation_date: 2012-06-15T14:22:57Z [Term] id: FYPO:0001165 name: inviable cell following anaerobic growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell that is exposed to anaerobic conditions fails to grow upon being returned to aerobic conditions, and eventually dies." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "essential following anaerobic growth" RELATED [PomBase:mah] synonym: "inviable following anaerobic vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000049 ! inviable cell is_a: FYPO:0001321 ! cellular physical quality phenotype during vegetative growth created_by: midori creation_date: 2012-06-15T14:28:05Z [Term] id: FYPO:0001166 name: normal growth on fructose carbon source def: "A vegetative cell population growth phenotype in which cells grow normally in a medium containing fructose as the carbon source." [PomBase:mah] synonym: "normal cell population growth on fructose carbon source" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal vegetative cell population growth on fructose carbon source" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0000047 ! normal cell population growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:15824 ! D-fructose relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:15824 ! D-fructose created_by: midori creation_date: 2012-06-18T14:58:12Z [Term] id: FYPO:0001167 name: abnormal ATPase activity def: "A molecular function phenotype in which the observed rate of ATPase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0016887 ! ATPase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0016887 ! ATPase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-06-18T15:16:22Z [Term] id: FYPO:0001168 name: decreased ATPase activity def: "A molecular function phenotype in which the observed rate of ATPase activity is decreased." [PomBase:mah] synonym: "reduced ATPase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0001167 ! abnormal ATPase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0016887 ! ATPase activity relationship: inheres_in GO:0016887 ! ATPase activity created_by: midori creation_date: 2012-06-18T15:16:30Z [Term] id: FYPO:0001169 name: normal proton transport def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which proton (H+) transport is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal hydrogen ion transport" EXACT [PomBase:mah] synonym: "normal proton transport during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal proton transport during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001071 ! normal transport is_a: FYPO:0001336 ! transport phenotype during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0015992 ! proton transport intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0015992 ! proton transport relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-06-18T15:18:27Z [Term] id: FYPO:0001170 name: decreased methionine import during nitrogen starvation def: "A cellular process phenotype in which the import of methionine into the cell occurs to a lower extent than normal when the cell is subject to nitrogen starvation." [PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "decreased L-methionine import during nitrogen starvation" EXACT [PomBase:mah] synonym: "decreased methionine import during nitrogen depletion" EXACT [PomBase:vw] synonym: "decreased methionine import during nitrogen deprivation" EXACT [PomBase:vw] synonym: "decreased methionine import into cell during nitrogen starvation" EXACT [PomBase:al] synonym: "decreased methionine transport into cell during nitrogen starvation" EXACT [PomBase:al] synonym: "decreased methionine uptake during nitrogen starvation" EXACT [PomBase:mah] synonym: "reduced methionine import during nitrogen starvation" EXACT [PomBase:mah] is_a: FYPO:0001558 ! decreased methionine import is_a: FYPO:0001648 ! abnormal amino acid import during nitrogen starvation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in GO:1903813 ! L-methionine import into cell relationship: happens_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in GO:1903813 ! L-methionine import into cell created_by: midori creation_date: 2012-06-18T15:29:46Z [Term] id: FYPO:0001171 name: decreased cellular pH def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the measured intracellular pH is lower than normal." [PomBase:mah] synonym: "decreased cellular pH during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular pH during vegetative growth" EXACT [PomBase:mah] synonym: "decreased cellular pH level" EXACT [PomBase:al] synonym: "reduced cellular pH" EXACT [PomBase:mah] is_a: FYPO:0001320 ! vegetative cell phenotype is_a: FYPO:0003037 ! abnormal cell phenotype created_by: midori creation_date: 2012-06-18T15:37:06Z [Term] id: FYPO:0001172 name: abnormal 7-methylguanosine cap hypermethylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which hypermethylation of the 7-(mono)methylguanosine (m(7)G) cap structure at the 2' position of the guanosine residue to form a 2,2,7-trimethylguanosine cap structure is abnormal." [PomBase:mah] synonym: "abnormal 2,2,7-trimethylguanosine cap formation" EXACT [GO:0036261, PomBase:mah] synonym: "abnormal 7-methylguanosine cap hypermethylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal 7-methylguanosine cap hypermethylation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal conversion of m(7)G to m(3)G" EXACT [GO:0036261, PomBase:mah] synonym: "abnormal snoRNA capping" NARROW [GO:0036261, PomBase:mah] synonym: "abnormal snRNA capping" NARROW [GO:0036261, PomBase:mah] synonym: "abnormal TMG cap formation" EXACT [GO:0036261, PomBase:mah] is_a: FYPO:0000370 ! abnormal RNA modification is_a: FYPO:0001553 ! abnormal RNA processing intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0036261 ! 7-methylguanosine cap hypermethylation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0036261 ! 7-methylguanosine cap hypermethylation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-06-18T15:51:40Z [Term] id: FYPO:0001173 name: abolished 7-methylguanosine cap hypermethylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which hypermethylation of the 7-(mono)methylguanosine (m(7)G) cap structure at the 2' position of the guanosine residue to form a 2,2,7-trimethylguanosine cap structure is abolished." [GO:0036261, PomBase:mah] synonym: "2,2,7-trimethylguanosine cap formation abolished" EXACT [GO:0036261, PomBase:mah] synonym: "7-methylguanosine cap hypermethylation abolished" EXACT [PomBase:mah] synonym: "7-methylguanosine cap hypermethylation abolished during vegetative growth" EXACT [PomBase:mah] synonym: "abolished 7-methylguanosine cap hypermethylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "conversion of m(7)G to m(3)G abolished" EXACT [GO:0036261, PomBase:mah] synonym: "snoRNA capping abolished" NARROW [GO:0036261, PomBase:mah] synonym: "snRNA capping abolished" NARROW [GO:0036261, PomBase:mah] synonym: "TMG cap formation abolished" EXACT [GO:0036261, PomBase:mah] is_a: FYPO:0000371 ! abolished RNA modification is_a: FYPO:0001172 ! abnormal 7-methylguanosine cap hypermethylation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0036261 ! 7-methylguanosine cap hypermethylation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0036261 ! 7-methylguanosine cap hypermethylation created_by: midori creation_date: 2012-06-18T15:57:19Z [Term] id: FYPO:0001174 name: normal growth on sucrose carbon source def: "A vegetative cell population growth phenotype in which cells grow normally in a medium containing sucrose as the carbon source." [PomBase:mah] synonym: "normal cell population growth on sucrose carbon source" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal vegetative cell population growth on sucrose carbon source" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0000047 ! normal cell population growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:17992 ! sucrose relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:17992 ! sucrose created_by: midori creation_date: 2012-06-21T11:11:55Z [Term] id: FYPO:0001175 name: normal growth on maltose carbon source def: "A vegetative cell population growth phenotype in which cells grow normally in a medium containing maltose as the carbon source." [PomBase:mah] synonym: "normal cell population growth on maltose carbon source" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal vegetative cell population growth on maltose carbon source" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0000047 ! normal cell population growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:17306 ! maltose relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:17306 ! maltose created_by: midori creation_date: 2012-06-21T11:12:36Z [Term] id: FYPO:0001176 name: decreased cell population growth on sucrose carbon source def: "A vegetative cell population growth phenotype in which cell growth is decreased relative to normal in a medium containing sucrose as the carbon source." [PomBase:mah] comment: Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "decreased growth on sucrose carbon source" BROAD [PomBase:mah] synonym: "decreased vegetative cell growth on sucrose carbon source" EXACT [PomBase:mah] synonym: "reduced cell growth on sucrose carbon source" RELATED [PomBase:mah] synonym: "slow cell growth on sucrose carbon source" NARROW [PomBase:mah] is_a: FYPO:0001355 ! decreased vegetative cell population growth intersection_of: FYPO:0000046 ! decreased cell population growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:17992 ! sucrose relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:17992 ! sucrose created_by: midori creation_date: 2012-06-21T11:13:07Z [Term] id: FYPO:0001177 name: decreased cell population growth on trehalose carbon source def: "A vegetative cell population growth phenotype in which cell growth is decreased relative to normal in a medium containing trehalose as the carbon source." [PomBase:mah] comment: Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "decreased growth on trehalose carbon source" BROAD [PomBase:mah] synonym: "decreased vegetative cell growth on trehalose carbon source" EXACT [PomBase:mah] synonym: "reduced cell growth on trehalose carbon source" EXACT [PomBase:mah] synonym: "slow cell growth on trehalose carbon source" NARROW [PomBase:mah] is_a: FYPO:0001355 ! decreased vegetative cell population growth intersection_of: FYPO:0000046 ! decreased cell population growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:27082 ! trehalose relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:27082 ! trehalose created_by: midori creation_date: 2012-06-21T11:13:29Z [Term] id: FYPO:0001178 name: loss of viability upon nitrogen starvation def: "A cell population phenotype in which a smaller than normal proportion of the population remains viable when cells in a culture in stationary phase are deprived of nitrogen." [PomBase:mah] comment: Use this term to annotate experiments in which a culture is grown to stationary phase under nitrogen-depleted conditions, and then the number of cells viable enough to form a colony upon return to conditions supporting vegetative growth is measured and compared to wild type. Also consider 'sensitive to nitrogen starvation' (FYPO:0002124). synonym: "decreased viability upon nitrogen starvation" EXACT [PomBase:mah] synonym: "loss of cell population viability upon nitrogen starvation" EXACT [PomBase:mah] synonym: "loss of viability in stationary phase upon nitrogen depletion" RELATED [PomBase:mah] synonym: "loss of viability upon nitrogen depletion" EXACT [PomBase:al] synonym: "loss of viability upon nitrogen deprivation" EXACT [PomBase:mah] synonym: "reduced viability upon nitrogen starvation" EXACT [PomBase:mah] is_a: FYPO:0000244 ! loss of viability upon nutrient depletion created_by: midori creation_date: 2012-06-27T14:04:23Z [Term] id: FYPO:0001179 name: protein localization abolished during vegetative growth def: "A cell phenotype in which a protein does not localize to, and is therefore absent from, a place where it is normally found in the vegetative growth phase of the life cycle." [PomBase:mah] comment: We recommend using one of the more specific terms instead of annotating to this term directly, if possible. If this term is used, we recommend noting which protein(s) were used in the assay. synonym: "abolished protein localization during vegetative growth" EXACT [PomBase:mah] synonym: "protein absent from specific location in cell during vegetative growth" RELATED [PomBase:mah] synonym: "protein localisation abolished during vegetative growth" EXACT [PomBase:mah] synonym: "protein localization abolished during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000443 ! abnormal protein localization during vegetative growth is_a: FYPO:0001375 ! protein localization abolished intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0034613 ! cellular protein localization relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0034613 ! cellular protein localization created_by: midori creation_date: 2012-06-27T15:07:09Z [Term] id: FYPO:0001180 name: increased protein tyrosine phosphorylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of tyrosine residues in one or more specific proteins, or of specific protein sites, occurs to a greater extent than normal." [PomBase:mah] synonym: "increased peptidyl-tyrosine phosphorylation" EXACT [GO:0018108, PomBase:mah] synonym: "increased protein tyrosine phosphorylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein tyrosine phosphorylation during vegetative growth" EXACT [PomBase:mah] synonym: "increased tyrosine phosphorylation" EXACT [PomBase:al] is_a: FYPO:0001038 ! increased protein phosphorylation during vegetative growth intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0018108 ! peptidyl-tyrosine phosphorylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0018108 ! peptidyl-tyrosine phosphorylation created_by: midori creation_date: 2012-06-27T15:32:08Z [Term] id: FYPO:0001181 name: normal maltase activity def: "A molecular function phenotype in which the observed rate of maltose alpha-glucosidase (also known as maltase) activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal maltose alpha-glucosidase activity" EXACT [GO:0032450, PomBase:mah] is_a: FYPO:0001182 ! normal alpha-glucosidase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0032450 ! maltose alpha-glucosidase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0032450 ! maltose alpha-glucosidase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-07-05T13:33:02Z [Term] id: FYPO:0001182 name: normal alpha-glucosidase activity def: "A molecular function phenotype in which the observed rate of an alpha-glucosidase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004558 ! alpha-1,4-glucosidase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0004558 ! alpha-1,4-glucosidase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-07-05T13:33:56Z [Term] id: FYPO:0001183 name: abnormal alpha-glucosidase activity def: "A molecular function phenotype in which the observed rate of an alpha-glucosidase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004558 ! alpha-1,4-glucosidase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004558 ! alpha-1,4-glucosidase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-07-05T13:36:08Z [Term] id: FYPO:0001184 name: abnormal maltase activity def: "A molecular function phenotype in which the observed rate of maltose alpha-glucosidase (also known as maltase) activity is abnormal." [PomBase:mah] synonym: "abnormal maltose alpha-glucosidase activity" EXACT [GO:0032450, PomBase:mah] is_a: FYPO:0001183 ! abnormal alpha-glucosidase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0032450 ! maltose alpha-glucosidase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0032450 ! maltose alpha-glucosidase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-07-05T13:36:57Z [Term] id: FYPO:0001185 name: decreased alpha-glucosidase activity def: "A molecular function phenotype in which the observed rate of an alpha-glucosidase activity is decreased." [PomBase:mah] synonym: "reduced alpha-glucosidase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0001183 ! abnormal alpha-glucosidase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004558 ! alpha-1,4-glucosidase activity relationship: inheres_in GO:0004558 ! alpha-1,4-glucosidase activity created_by: midori creation_date: 2012-07-05T13:38:13Z [Term] id: FYPO:0001186 name: decreased maltase activity def: "A molecular function phenotype in which the observed rate of maltose alpha-glucosidase (also known as maltase) activity is decreased." [PomBase:mah] synonym: "decreased maltose alpha-glucosidase activity" EXACT [GO:0032450, PomBase:mah] synonym: "reduced maltase activity" EXACT [PomBase:mah] synonym: "reduced maltose alpha-glucosidase activity" RELATED [GO:0032450, PomBase:mah] is_a: FYPO:0001184 ! abnormal maltase activity is_a: FYPO:0001185 ! decreased alpha-glucosidase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0032450 ! maltose alpha-glucosidase activity relationship: inheres_in GO:0032450 ! maltose alpha-glucosidase activity created_by: midori creation_date: 2012-07-05T13:38:33Z [Term] id: FYPO:0001187 name: decreased cell density in stationary phase def: "A cell population phenotype in which a population reaches stationary phase at, and maintains, a lower cell density than wild type." [PomBase:mah] synonym: "reduced cell density in stationary phase" EXACT [PomBase:mah] is_a: FYPO:0000003 ! cell population phenotype is_a: FYPO:0001985 ! abnormal phenotype created_by: midori creation_date: 2012-07-05T14:04:36Z [Term] id: FYPO:0001188 name: sensitive to Calcofluor White def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to Calcofluor White. Cells stop growing (and may die) at a concentration of Calcofluor White that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to Calcofluor White" EXACT [PomBase:mah] synonym: "sensitive to Calcofluor White during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to Calcofluor White during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:50011 ! Calcofluor White relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:50011 ! Calcofluor White created_by: midori creation_date: 2012-07-05T14:32:40Z [Term] id: FYPO:0001189 name: sensitive to cilofungin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to cilofungin. Cells stop growing (and may die) at a concentration of cilofungin that allows wild type cells to grow." [PomBase:mah] comment: Cilofungin is an echinocandin antibiotic, related to echinocandin B. synonym: "hypersensitive to cilofungin" EXACT [PomBase:mah] synonym: "sensitive to cilofungin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to cilofungin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:315019 ! cilofungin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:315019 ! cilofungin created_by: midori creation_date: 2012-07-05T14:34:21Z [Term] id: FYPO:0001190 name: sensitive to cell wall-degrading enzymes alt_id: FYPO:0001191 def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to one or more enzymes that degrades cell wall polysaccharides. Cells stop growing (and may die) at a concentration of such enzymes that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to cell wall-degrading enzymes" EXACT [PomBase:mah] synonym: "sensitive to beta-1,3-glucan laminaripentaohydrolase" NARROW [PomBase:al, PomBase:mah] synonym: "sensitive to cell wall-degrading enzymes during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to cell wall-degrading enzymes during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to lysing enzymes from Trichoderma harzianum" NARROW [PomBase:al] synonym: "sensitive to Lyticase" NARROW [PomBase:mah] synonym: "sensitive to Novozyme 234" NARROW [PomBase:mah] synonym: "sensitive to Zymolyase" NARROW [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth created_by: midori creation_date: 2012-07-05T14:41:18Z [Term] id: FYPO:0001192 name: normal growth on cell wall-degrading enzymes alt_id: FYPO:0001193 def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which vegetative cell growth is normal (i.e. indistinguishable from wild type) in a medium containing one or more enzymes that degrades cell wall polysaccharides." [PomBase:mah] synonym: "normal cell population growth in presence of cell wall-degrading enzymes" EXACT [PomBase:mah] synonym: "normal cell population growth on beta-1,3-glucan laminaripentaohydrolase" NARROW [PomBase:al, PomBase:mah] synonym: "normal cell population growth on cell wall-degrading enzymes" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cell population growth on lysing enzymes from Trichoderma harzianum" NARROW [PomBase:al] synonym: "normal cell population growth on Lyticase" NARROW [PomBase:mah] synonym: "normal cell population growth on Novozyme 234" NARROW [PomBase:mah] synonym: "normal cell population growth on Zymolyase" NARROW [PomBase:mah] synonym: "normal cellular response to cell wall-degrading enzymes" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on cell wall-degrading enzymes" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth created_by: midori creation_date: 2012-07-05T15:35:28Z [Term] id: FYPO:0001194 name: increased beta-glucan level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of beta-D-glucan measured in the cell is greater than normal." [PomBase:mah] synonym: "increased beta-D-glucan level" EXACT [CHEBI:28793, PomBase:mah] synonym: "increased beta-glucan accumulation" RELATED [PomBase:mah] synonym: "increased beta-glucan level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased beta-glucan level during vegetative growth" EXACT [PomBase:mah] synonym: "increased cellular beta-glucan level" EXACT [PomBase:mah] is_a: FYPO:0001083 ! increased polysaccharide level is_a: FYPO:0002627 ! altered level of substance in cell wall intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0009277 ! fungal-type cell wall intersection_of: towards CHEBI:28793 ! beta-D-glucan relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0009277 ! fungal-type cell wall relationship: towards CHEBI:28793 ! beta-D-glucan created_by: midori creation_date: 2012-07-05T15:53:01Z [Term] id: FYPO:0001195 name: decreased galactomannan level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of galactomannan measured in the cell is lower than normal." [PomBase:mah] synonym: "decreased cellular galactomannan level" EXACT [PomBase:mah] synonym: "decreased galactomannan accumulation" RELATED [PomBase:mah] synonym: "decreased galactomannan level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased galactomannan level during vegetative growth" EXACT [PomBase:mah] synonym: "reduced galactomannan level" EXACT [PomBase:mah] is_a: FYPO:0001080 ! decreased polysaccharide level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:27680 ! galactomannan relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:27680 ! galactomannan created_by: midori creation_date: 2012-07-05T15:54:27Z [Term] id: FYPO:0001196 name: normal alpha-glucan level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of alpha-D-glucan measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal alpha-D-glucan level" EXACT [CHEBI:22385, PomBase:mah] synonym: "normal alpha-glucan accumulation" RELATED [PomBase:mah] synonym: "normal alpha-glucan level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal alpha-glucan level during vegetative growth" EXACT [PomBase:mah] synonym: "normal cellular alpha-glucan level" EXACT [PomBase:al] is_a: FYPO:0001077 ! normal polysaccharide level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:22385 ! alpha-D-glucan relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:22385 ! alpha-D-glucan created_by: midori creation_date: 2012-07-05T15:55:45Z [Term] id: FYPO:0001197 name: decreased cellular calcium level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of calcium ion measured in a cell is lower than normal." [PomBase:mah] synonym: "decreased calcium accumulation" RELATED [PomBase:al] synonym: "decreased cellular calcium ion level" EXACT [PomBase:mah] synonym: "decreased cellular calcium level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular calcium level during vegetative growth" EXACT [PomBase:mah] synonym: "reduced cellular calcium level" EXACT [PomBase:mah] is_a: FYPO:0001329 ! decreased level of substance in cell during vegetative growth is_a: FYPO:0001462 ! altered cellular calcium level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:29108 ! calcium(2+) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:29108 ! calcium(2+) created_by: midori creation_date: 2012-07-05T16:12:05Z [Term] id: FYPO:0001198 name: increased cellular calcium level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of calcium ion measured in a cell is higher than normal." [PomBase:mah] synonym: "increased calcium accumulation" RELATED [PomBase:mah] synonym: "increased cellular calcium ion level" EXACT [PomBase:mah] synonym: "increased cellular calcium level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular calcium level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth is_a: FYPO:0001462 ! altered cellular calcium level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:29108 ! calcium(2+) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:29108 ! calcium(2+) created_by: midori creation_date: 2012-07-05T16:13:54Z [Term] id: FYPO:0001199 name: normal cellular calcium level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of calcium ion measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular calcium accumulation" RELATED [PomBase:mah] synonym: "normal cellular calcium ion level" EXACT [PomBase:mah] synonym: "normal cellular calcium level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular calcium level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:29108 ! calcium(2+) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:29108 ! calcium(2+) created_by: midori creation_date: 2012-07-05T16:14:49Z [Term] id: FYPO:0001200 name: abnormal cellular response to calcium starvation def: "A stress response phenotype observed in the vegetative growth phase of the life cycle in which the response to calcium starvation is abnormal." [PomBase:mah] comment: Use this term if you have assayed the response to calcium starvation at the subcellular or molecular level. If you have assayed growth of cells exposed to calcium starvation in culture, use 'sensitive to calcium starvation' (FYPO:0001201). synonym: "abnormal cellular response to calcium depletion" EXACT [PomBase:vw] synonym: "abnormal cellular response to calcium deprivation" EXACT [PomBase:vw] synonym: "abnormal cellular response to calcium ion starvation" EXACT [GO:0072732, PomBase:mah] synonym: "abnormal cellular response to calcium starvation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal cellular response to calcium starvation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001339 ! abnormal cellular response to starvation during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0072732 ! cellular response to calcium ion starvation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0072732 ! cellular response to calcium ion starvation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-07-05T16:38:24Z [Term] id: FYPO:0001201 name: sensitive to calcium starvation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to calcium starvation." [PomBase:mah] comment: Use this term if you have assayed growth of cells exposed to calcium starvation in culture. If you have assayed the response to calcium starvation at the subcellular or molecular level, consider annotating to 'abnormal cellular response to calcium starvation' (FYPO:0001200). synonym: "hypersensitive to calcium starvation" EXACT [PomBase:mah] synonym: "reduced growth in low calcium" RELATED [PomBase:vw] synonym: "sensitive to calcium depletion" EXACT [PomBase:vw] synonym: "sensitive to calcium deprivation" EXACT [PomBase:vw] synonym: "sensitive to calcium ion starvation" EXACT [GO:0072732, PomBase:mah] synonym: "sensitive to calcium starvation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to calcium starvation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000304 ! sensitive to stress during vegetative growth created_by: midori creation_date: 2012-07-05T16:43:08Z [Term] id: FYPO:0001202 name: normal cellular response to calcium starvation def: "A cellular response phenotype observed in the vegetative growth phase of the life cycle in which the cellular response to calcium starvation is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular response to calcium depletion" EXACT [PomBase:vw] synonym: "normal cellular response to calcium deprivation" EXACT [PomBase:vw] synonym: "normal cellular response to calcium ion starvation" EXACT [GO:0072732, PomBase:mah] synonym: "normal cellular response to calcium starvation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular response to calcium starvation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000968 ! normal cellular response to stress intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072732 ! cellular response to calcium ion starvation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072732 ! cellular response to calcium ion starvation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-07-05T16:45:20Z [Term] id: FYPO:0001203 name: coflocculating cells def: "A cell population phenotype that reflects increased occurrence of coflocculation. In coflocculation, yeast cells coaggregate with cells of another species, usually bacteria." [PMID:11472912, PomBase:mah] comment: Note: coflocculation between S. pombe and E. coli is sensitive to mannose but not to glucose or galactose. Plant lectins such as HHA, GNA, NPA, or Concanavalin A (ConA) decrease but do not abolish S. pombe-E. coli coflocculation. Cations have different effects: Li+, Na+, K+, Mg2+ or Mn2+ increase coflocculation, Co2+, Zn2+ , and Ca2+ have no effect, and Cu2+ or Hg2+ completely abolish coflocculation. synonym: "co-flocculating cells" EXACT [PomBase:mah] synonym: "increased coflocculation" EXACT [PomBase:mah] is_a: FYPO:0000155 ! increased flocculation created_by: midori creation_date: 2012-07-06T15:40:35Z [Term] id: FYPO:0001204 name: mistimed mitosis def: "A cellular process phenotype in which cells enter mitosis earlier or later than normal, relative to cell size or DNA integrity checkpoint status." [PomBase:mah] synonym: "abnormal onset of mitosis" EXACT [PomBase:mah] synonym: "mistimed mitosis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "mistimed mitosis during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000337 ! abnormal mitosis is_a: PATO:0002325 ! onset quality intersection_of: PATO:0002325 ! onset quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0007067 ! mitotic nuclear division intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0007067 ! mitotic nuclear division relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-07-06T16:15:36Z [Term] id: FYPO:0001205 name: abolished alpha-glucosidase activity def: "A molecular function phenotype in which alpha-glucosidase activity is absent." [PomBase:mah] synonym: "alpha-glucosidase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0004558 ! alpha-1,4-glucosidase activity relationship: towards GO:0004558 ! alpha-1,4-glucosidase activity created_by: midori creation_date: 2012-07-09T17:10:25Z [Term] id: FYPO:0001206 name: abolished maltase activity def: "A molecular function phenotype in which maltase activity is absent." [PomBase:mah] synonym: "abolished protease activity" EXACT [PomBase:mah] synonym: "maltase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0001184 ! abnormal maltase activity is_a: FYPO:0001205 ! abolished alpha-glucosidase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0032450 ! maltose alpha-glucosidase activity relationship: towards GO:0032450 ! maltose alpha-glucosidase activity created_by: midori creation_date: 2012-07-09T17:13:55Z [Term] id: FYPO:0001207 name: sensitive to raffinose def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to raffinose. Cells stop growing (and may die) at a concentration of raffinose that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to raffinose" EXACT [PomBase:mah] synonym: "sensitive to raffinose during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to raffinose during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:16634 ! raffinose relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:16634 ! raffinose created_by: midori creation_date: 2012-07-12T10:30:03Z [Term] id: FYPO:0001208 name: substance absent from cell during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of a specific substance measured in a cell is too low to detect." [PomBase:mah] synonym: "substance absent from cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001329 ! decreased level of substance in cell during vegetative growth is_a: FYPO:0001888 ! substance absent from cell intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:24431 ! chemical entity relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:24431 ! chemical entity created_by: midori creation_date: 2012-07-12T12:09:35Z [Term] id: FYPO:0001209 name: polysaccharide absent from cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of a polysaccharide measured in a cell is too low to detect." [PomBase:mah] synonym: "polysaccharide absent from cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "polysaccharide absent from cell during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001080 ! decreased polysaccharide level is_a: FYPO:0001208 ! substance absent from cell during vegetative growth intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:18154 ! polysaccharide relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:18154 ! polysaccharide created_by: midori creation_date: 2012-07-12T12:12:20Z [Term] id: FYPO:0001210 name: Glc2Man9GlcNAc absent from cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of Glc2Man9GlcNAc2 measured in a cell is too low to detect. Glc2Man9GlcNAc2 is an N-glycan that is involved in post-translational modification of proteins, and consists of a branched ten-membered mannooligosaccharide containing two D-glucose residues, nine D-mannosyl residues and two N-acetylglucosamine residues." [CHEBI:59082, PMID:9813085, PomBase:mah] comment: Note that these terms treat Man(n)GlcNAc and Man(n)GlcNAc2 as equivalent. The reason is that the GlcNAc2 form is attached to N-linked glycoproteins, but the GlcNAc form is what is usually detected in experiments, following cleavage by endoglycosidase H. For the purposes of observing and interpreting phenotypes, the difference is not significant. synonym: "absent Glc2Man9GlcNAc" EXACT [PomBase:al] synonym: "Glc2Man9GlcNAc absent from cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "Glc2Man9GlcNAc absent from cell during vegetative growth" EXACT [PomBase:mah] synonym: "Glc2Man9GlcNAc2 absent from cell" EXACT [PomBase:mah] is_a: FYPO:0001209 ! polysaccharide absent from cell intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:59082 ! N-{alpha-Glc-(1->3)-alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residue relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:59082 ! N-{alpha-Glc-(1->3)-alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residue created_by: midori creation_date: 2012-07-12T12:13:39Z [Term] id: FYPO:0001211 name: Glc3Man9GlcNAc absent from cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of Glc3Man9GlcNAc measured in a cell is too low to detect. Glc3Man9GlcNAc2 is an N-glycan that is involved in post-translational modification of proteins, and consists of a branched ten-membered mannooligosaccharide containing three D-glucose residues, nine D-mannosyl residues and two N-acetylglucosamine residues." [CHEBI:53019, PMID:9813085, PomBase:mah] comment: Note that these terms treat Man(n)GlcNAc and Man(n)GlcNAc2 as equivalent. The reason is that the GlcNAc2 form is attached to N-linked glycoproteins, but the GlcNAc form is what is usually detected in experiments, following cleavage by endoglycosidase H. For the purposes of observing and interpreting phenotypes, the difference is not significant. synonym: "absent Glc3Man9GlcNAc" EXACT [PomBase:al] synonym: "Glc3Man9GlcNAc absent from cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "Glc3Man9GlcNAc absent from cell during vegetative growth" EXACT [PomBase:mah] synonym: "Glc3Man9GlcNAc2 absent from cell" EXACT [PomBase:mah] is_a: FYPO:0001209 ! polysaccharide absent from cell is_a: FYPO:0001289 ! decreased phospholipid level intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:53019 ! glycan G00008 relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:53019 ! glycan G00008 created_by: midori creation_date: 2012-07-12T12:15:33Z [Term] id: FYPO:0001212 name: decreased Glc1Man9GlcNAc level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of Glc1Man9GlcNAc2 measured in a cell is lower than normal. Glc1Man9GlcNAc2 is an N-glycan that is involved in post-translational modification of proteins, and consists of a branched ten-membered mannooligosaccharide containing one D-glucose residue, nine D-mannosyl residues and two N-acetylglucosamine residues." [CHEBI:59080, PMID:9813085, PomBase:mah] comment: Note that these terms treat Man(n)GlcNAc and Man(n)GlcNAc2 as equivalent. The reason is that the GlcNAc2 form is attached to N-linked glycoproteins, but the GlcNAc form is what is usually detected in experiments, following cleavage by endoglycosidase H. For the purposes of observing and interpreting phenotypes, the difference is not significant. synonym: "decreased cellular Glc1Man9GlcNAc level" EXACT [PomBase:al] synonym: "decreased Glc1Man9GlcNAc accumulation" RELATED [PomBase:mah] synonym: "decreased Glc1Man9GlcNAc level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased Glc1Man9GlcNAc level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased Glc1Man9GlcNAc2 level" EXACT [PomBase:mah] synonym: "reduced Glc1Man9GlcNAc level" EXACT [PomBase:mah] is_a: FYPO:0001080 ! decreased polysaccharide level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:59080 ! N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residue relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:59080 ! N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residue created_by: midori creation_date: 2012-07-12T12:16:24Z [Term] id: FYPO:0001213 name: increased Man8GlcNAc level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of Man8GlcNAc2 measured in a cell is higher than normal. Man8GlcNAc2 is any N-glycan that consists of a branched ten-membered mannooligosaccharide containing eight D-mannosyl residues and two N-acetylglucosamine residues." [CHEBI:64048, CHEBI:64052, PMID:9813085, PomBase:mah] comment: Note that these terms treat Man(n)GlcNAc and Man(n)GlcNAc2 as equivalent. The reason is that the GlcNAc2 form is attached to N-linked glycoproteins, but the GlcNAc form is what is usually detected in experiments, following cleavage by endoglycosidase H. For the purposes of observing and interpreting phenotypes, the difference is not significant. synonym: "increased cellular Man8GlcNAc level" EXACT [PomBase:al] synonym: "increased Man8GlcNAc accumulation" RELATED [PomBase:mah] synonym: "increased Man8GlcNAc level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased Man8GlcNAc level during vegetative growth" EXACT [PomBase:mah] synonym: "increased Man8GlcNAc2 level" EXACT [PomBase:mah] is_a: FYPO:0001083 ! increased polysaccharide level created_by: midori creation_date: 2012-07-12T12:17:32Z [Term] id: FYPO:0001214 name: sensitive to potassium chloride def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to potassium chloride. Cells stop growing (and may die) at a concentration of potassium chloride that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to potassium chloride" EXACT [PomBase:mah] synonym: "sensitive to potassium chloride during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to potassium chloride during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:32588 ! potassium chloride relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:32588 ! potassium chloride created_by: midori creation_date: 2012-07-12T14:21:19Z [Term] id: FYPO:0001215 name: normal protein complex assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the assembly of a protein complex at the cellular level is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular protein complex assembly" EXACT [GO:0043623] synonym: "normal protein complex assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein complex assembly during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001319 ! normal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0043623 ! cellular protein complex assembly intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0043623 ! cellular protein complex assembly relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-07-12T14:30:00Z [Term] id: FYPO:0001216 name: normal SAGA complex assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the assembly of a SAGA complex onto chromatin is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal SAGA complex assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal SAGA complex assembly during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001215 ! normal protein complex assembly intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0036285 ! SAGA complex assembly intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0036285 ! SAGA complex assembly relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-07-12T14:32:23Z [Term] id: FYPO:0001217 name: abnormal nuclear import def: "A cellular process phenotype in which nuclear import is abnormal. Nuclear import is the directed movement of any substance out of the nucleus; import of all substances or a specific substance may be affected." [PomBase:mah] synonym: "abnormal nuclear import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal nuclear import during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000518 ! abnormal nuclear transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0051170 ! nuclear import intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0051170 ! nuclear import relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-07-12T14:39:54Z [Term] id: FYPO:0001218 name: abolished nuclear export during cellular response to nitrogen starvation def: "A cellular process phenotype in which nuclear export does not occur when the cell is subject to nitrogen starvation. Nuclear export is the directed movement of any substance out of the nucleus; export of all substances or a specific substance may be affected." [PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "abolished nuclear export during cellular response to nitrogen depletion" EXACT [PomBase:vw] synonym: "abolished nuclear export during cellular response to nitrogen deprivation" EXACT [PomBase:vw] synonym: "abolished nuclear export during cellular response to nitrogen starvation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "absent nuclear export during response to nitrogen starvation" EXACT [PomBase:mah] synonym: "nuclear export during response to nitrogen starvation abolished" EXACT [PomBase:mah] synonym: "nuclear export during response to nitrogen starvation abolished during vegetative growth" EXACT [PomBase:mah] synonym: "nuclear export in response to nitrogen starvation abolished" EXACT [PomBase:al] is_a: FYPO:0000507 ! abolished nuclear export intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0006995 ! cellular response to nitrogen starvation intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0051168 ! nuclear export relationship: during GO:0006995 ! cellular response to nitrogen starvation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0051168 ! nuclear export created_by: midori creation_date: 2012-07-12T14:41:50Z [Term] id: FYPO:0001219 name: increased protein level during cellular response to nitrogen starvation def: "A cell phenotype in which the amount of protein measured in a cell during a cellular response to nitrogen starvation is higher than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein accumulation during cellular response to nitrogen starvation" RELATED [PomBase:mah] synonym: "increased protein level during cellular response to nitrogen depletion" EXACT [PomBase:vw] synonym: "increased protein level during cellular response to nitrogen deprivation" EXACT [PomBase:vw] synonym: "increased protein level during nitrogen starvation" EXACT [PomBase:mah] is_a: FYPO:0000836 ! increased protein level is_a: FYPO:0004139 ! altered level of substance in cell during nitrogen starvation intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2012-07-12T15:10:12Z [Term] id: FYPO:0001220 name: increased protein level during cellular response to pheromone def: "A cell phenotype in which the amount of protein measured in a cell during a cellular response to a pheromone is higher than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein accumulation during cellular response to pheromone" RELATED [PomBase:mah] synonym: "increased protein level during cellular response to pheromone during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein level during cellular response to pheromone during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001327 ! increased protein level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0071444 ! cellular response to pheromone intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0071444 ! cellular response to pheromone relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2012-07-12T15:13:41Z [Term] id: FYPO:0001221 name: normal nucleus:cytoplasm ratio def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the ratio of the nuclear volume to the total cell volume is in the same range as wild type (approximately 0.076-0.089)." [PMID:17998401, PomBase:mah] synonym: "normal nuclear:cytoplasmic ratio" EXACT [PomBase:mah] synonym: "normal nuclear:cytoplasmic volume ratio" EXACT [PomBase:mah] synonym: "normal nucleus:cell volume ratio" EXACT [PomBase:mah] synonym: "normal nucleus:cytoplasm ratio during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal nucleus:cytoplasm ratio during vegetative growth" EXACT [PomBase:mah] synonym: "normal nucleus:cytoplasm volume ratio" EXACT [PomBase:mah] is_a: FYPO:0001312 ! normal vegetative phenotype is_a: FYPO:0001320 ! vegetative cell phenotype created_by: midori creation_date: 2012-07-12T15:15:47Z [Term] id: FYPO:0001222 name: binucleate vegetative cell def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which a cell contains two nuclei." [PomBase:mah] subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "binucleate cells during vegetative growth" EXACT [PomBase:al] synonym: "binucleate during vegetative growth" EXACT [PomBase:mah] synonym: "binucleate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000061 ! multinucleate vegetative cell is_a: PATO:0001406 ! binucleate intersection_of: PATO:0001406 ! binucleate intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) created_by: midori creation_date: 2012-07-12T15:37:08Z [Term] id: FYPO:0001223 name: binucleate multiseptate vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell has two nuclei and more than one septum. The septa are grouped together between the two nuclei." [PomBase:mah] synonym: "binucleate multiseptate cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "binucleate multiseptate cell during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001252 ! multinucleate multiseptate vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000118 ! multiseptate vegetative cell intersection_of: has_part FYPO:0001222 ! binucleate vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000118 ! multiseptate vegetative cell relationship: has_part FYPO:0001222 ! binucleate vegetative cell created_by: midori creation_date: 2012-07-12T15:39:43Z [Term] id: FYPO:0001224 name: binucleate monoseptate cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell has two nuclei and one septum." [PomBase:mah] synonym: "binucleate monoseptate cell during vegetative growth" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2012-07-12T15:40:42Z [Term] id: FYPO:0001225 name: monoseptate def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which a cell contains a single septum." [PomBase:mah] synonym: "monoseptate during mitotic cell cycle" RELATED [PomBase:mah] synonym: "monoseptate during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002342 ! septated vegetative cell created_by: midori creation_date: 2012-07-12T15:42:41Z [Term] id: FYPO:0001226 name: inviable mononucleate vegetative cell with mislocalized septum def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which a cell is inviable, and contains a single nucleus and an asymmetrically located septum." [PomBase:mah] synonym: "inviable mononucleate cell with mislocalized septum during vegetative growth" EXACT [PomBase:mah] synonym: "inviable mononucleate monoseptate vegetative cell with mislocalized septum" EXACT [PomBase:mah] synonym: "inviable mononucleate vegetative cell with abnormal septum location" EXACT [PomBase:mah] synonym: "inviable mononucleate vegetative cell with abnormal septum position" EXACT [PomBase:mah] synonym: "inviable mononucleate vegetative cell with asymmetric septum" EXACT [PomBase:mah] synonym: "inviable mononucleate vegetative cell with asymmetrically located septum" EXACT [PomBase:mah] synonym: "inviable mononucleate vegetative cell with mislocalised septum" EXACT [PomBase:mah] synonym: "inviable mononucleate vegetative cell with mislocalized septum during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable mononucleate vegetative cell with misplaced septum" EXACT [PomBase:vw] synonym: "inviable mononucleate vegetative cell with single mislocalized septum" EXACT [PomBase:mah] is_a: FYPO:0002303 ! inviable mononucleate monoseptate vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000060 ! mononucleate vegetative cell intersection_of: has_part FYPO:0000339 ! mislocalized septum during vegetative growth intersection_of: has_part FYPO:0001225 ! monoseptate intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000060 ! mononucleate vegetative cell relationship: has_part FYPO:0000339 ! mislocalized septum during vegetative growth relationship: has_part FYPO:0001225 ! monoseptate relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2012-07-12T15:44:34Z [Term] id: FYPO:0001227 name: protein mislocalized to cytoplasm during cellular response to hydrogen peroxide def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a protein that is not normally found in the cytoplasm is observed there, during a cellular response to hydrogen peroxide." [PomBase:mah] comment: Note that this term can be used to annotate any case where a protein is found in the cytoplasm in a mutant, but not in wild type. In some cases, there may be enough additional information to annotate to 'abnormal protein localization' (FYPO:0000443) or one of its descendants. synonym: "ectopic protein localization to cytoplasm during cellular response to hydrogen peroxide" EXACT [PomBase:vw] synonym: "protein mislocalised to cytoplasm during cellular response to hydrogen peroxide" EXACT [PomBase:mah] synonym: "protein mislocalized to cytoplasm during cellular response to H2O2" EXACT [PomBase:mah] synonym: "protein mislocalized to cytoplasm during cellular response to hydrogen peroxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein mislocalized to cytoplasm during cellular response to hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] synonym: "protein mislocalized to cytoplasm in response to hydrogen peroxide" EXACT [PomBase:al] is_a: FYPO:0000783 ! protein mislocalized to cytoplasm intersection_of: PATO:0000628 ! mislocalised intersection_of: exists_during GO:0070301 ! cellular response to hydrogen peroxide intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CHEBI:36080 ! protein intersection_of: towards GO:0005737 ! cytoplasm relationship: exists_during GO:0070301 ! cellular response to hydrogen peroxide relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CHEBI:36080 ! protein relationship: towards GO:0005737 ! cytoplasm created_by: midori creation_date: 2012-07-13T16:15:07Z [Term] id: FYPO:0001228 name: increased nuclear protein level during cellular response to hydrogen peroxide def: "A cell phenotype observed in vegetative growth phase of the life cycle, in which the amount of protein measured in the cell nucleus is higher than normal during a cellular response to hydrogen peroxide. Total protein or a specific protein may be affected." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased nuclear protein level during cellular response to H2O2" EXACT [PomBase:mah] synonym: "increased nuclear protein level during cellular response to hydrogen peroxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased nuclear protein level during cellular response to hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] synonym: "increased protein level in nucleus during cellular response to hydrogen peroxide" RELATED [PomBase:mah] synonym: "nuclear accumulation of protein during cellular response to hydrogen peroxide" EXACT [PomBase:mah] synonym: "nuclear protein accumulation during cellular response to hydrogen peroxide" RELATED [PomBase:mah] synonym: "nuclear protein accumulation during cellular response to hydrogen peroxide during vegetative growth" RELATED [PomBase:mah] synonym: "nuclear protein accumulation in response to hydrogen peroxide" RELATED [PomBase:al] is_a: FYPO:0000255 ! increased nuclear protein level during vegetative growth is_a: FYPO:0001102 ! increased protein level during cellular response to hydrogen peroxide intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0070301 ! cellular response to hydrogen peroxide intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005634 ! nucleus intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0070301 ! cellular response to hydrogen peroxide relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005634 ! nucleus relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2012-07-13T16:39:13Z [Term] id: FYPO:0001229 name: abnormal cell cortex morphology def: "A physical cellular phenotype in which the size, shape, or structure of all or part of the cell cortex is abnormal. The cell cortex is the region of a cell that lies just beneath the plasma membrane." [GO:0005938, PomBase:mah] comment: Note that an abnormal cell cortex organization process may, but does not necessarily, result in abnormal cell cortex morphology. is_a: FYPO:0000287 ! abnormal subcellular component is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: inheres_in GO:0005938 ! cell cortex intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0005938 ! cell cortex relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-07-16T13:51:27Z [Term] id: FYPO:0001230 name: abnormal cell cortex morphology during nitrogen starvation def: "A physical cellular phenotype in which the size, shape, or structure of all or part of the cell cortex is abnormal when the cell is subject to nitrogen starvation. The cell cortex is the region of a cell that lies just beneath the plasma membrane." [GO:0005938, PomBase:mah] comment: Note that an abnormal cell cortex organization process may, but does not necessarily, result in abnormal cell cortex morphology. This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "abnormal cell cortex morphology during nitrogen depletion" EXACT [PomBase:vw] synonym: "abnormal cell cortex morphology during nitrogen deprivation" EXACT [PomBase:vw] is_a: FYPO:0001229 ! abnormal cell cortex morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in GO:0005938 ! cell cortex intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in GO:0005938 ! cell cortex relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-07-16T13:52:15Z [Term] id: FYPO:0001231 name: normal cell cortex morphology def: "A physical cellular phenotype in which the size, shape, and structure of the cell cortex is normal (i.e. indistinguishable from wild type). The cell cortex is the region of a cell that lies just beneath the plasma membrane." [GO:0005938, PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype: Note that an abnormal cell cortex organization process may, but does not necessarily, result in abnormal cell cortex morphology. subset: qc_do_not_manually_annotate is_a: FYPO:0001233 ! normal subcellular component is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: inheres_in GO:0005938 ! cell cortex intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0005938 ! cell cortex relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-07-16T13:54:21Z [Term] id: FYPO:0001232 name: normal cell cortex morphology during nitrogen starvation def: "A physical cellular phenotype in which the size, shape, and structure of the cell cortex are normal when the cell is subject to nitrogen starvation. The cell cortex is the region of a cell that lies just beneath the plasma membrane." [GO:0005938, PomBase:mah] comment: Note that an abnormal cell cortex organization process may, but does not necessarily, result in abnormal cell cortex morphology. This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "normal cell cortex morphology during nitrogen depletion" EXACT [PomBase:vw] synonym: "normal cell cortex morphology during nitrogen deprivation" EXACT [PomBase:vw] is_a: FYPO:0001231 ! normal cell cortex morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in GO:0005938 ! cell cortex intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in GO:0005938 ! cell cortex relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-07-16T13:56:11Z [Term] id: FYPO:0001233 name: normal subcellular component def: "A cell phenotype in which the amount, distribution, or morphology of a cell part is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "normal subcellular structure" RELATED [PomBase:al] is_a: FYPO:0000136 ! cellular physical quality phenotype is_a: FYPO:0000257 ! normal phenotype intersection_of: PATO:0001241 ! physical object quality intersection_of: inheres_in GO:0044464 ! cell part intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0044464 ! cell part relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-07-16T13:59:40Z [Term] id: FYPO:0001234 name: slow vegetative cell population growth def: "A cell population phenotype in which vegetative cell population growth is slower than normal." [PomBase:mah] comment: Use this term when growth rate, e.g. as measured by population doubling time, is reduced. Note that with growth on plates, growth rate can be difficult to assess, so it may be better to use 'decreased cell population growth' (FYPO:0000046). Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "decreased vegetative cell population growth rate" EXACT [PomBase:mah] synonym: "growth defect, slow growth" BROAD [PomBase:mah] synonym: "increased doubling time" RELATED [PomBase:vw] synonym: "reduced vegetative cell population growth rate" EXACT [PomBase:mah] is_a: FYPO:0001356 ! abnormal vegetative cell population growth is_a: FYPO:0002060 ! viable vegetative cell population is_a: PATO:0000911 ! decreased rate intersection_of: PATO:0000911 ! decreased rate intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase created_by: midori creation_date: 2012-07-16T14:20:51Z [Term] id: FYPO:0001235 name: decreased extent of cell population growth def: "A cellular process phenotype in which cell growth in a cell population occurs to a lower extent than normal, i.e. the population stops growing earlier than normal." [PomBase:mah] synonym: "reduced extent of cell population growth" EXACT [PomBase:mah] is_a: FYPO:0000003 ! cell population phenotype is_a: FYPO:0001985 ! abnormal phenotype relationship: has_part FYPO:0000046 ! decreased cell population growth created_by: midori creation_date: 2012-07-16T14:25:09Z [Term] id: FYPO:0001236 name: normal growth on cycloheximide def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing cycloheximide." [PomBase:mah] synonym: "normal cell population growth in presence of cycloheximide" EXACT [PomBase:mah] synonym: "normal cell population growth on cycloheximide" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to cycloheximide" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on cycloheximide" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:27641 ! cycloheximide relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:27641 ! cycloheximide created_by: midori creation_date: 2012-07-16T15:25:03Z [Term] id: FYPO:0001237 name: normal growth on cadmium def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing cadmium ions." [PomBase:mah] synonym: "normal cell population growth in presence of cadmium" EXACT [PomBase:mah] synonym: "normal cell population growth on cadmium" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cell population growth on cadmium ion" EXACT [PomBase:mah] synonym: "normal cellular response to cadmium" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on cadmium" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:22978 ! cadmium molecular entity relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:22978 ! cadmium molecular entity created_by: midori creation_date: 2012-07-16T15:25:47Z [Term] id: FYPO:0001238 name: normal growth on staurosporine def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing staurosporine." [PomBase:mah] synonym: "normal cell population growth in presence of staurosporine" EXACT [PomBase:mah] synonym: "normal cell population growth on staurosporine" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to staurosporine" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on staurosporine" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:15738 ! staurosporine relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:15738 ! staurosporine created_by: midori creation_date: 2012-07-16T15:27:03Z [Term] id: FYPO:0001239 name: normal growth on tert-butyl hydroperoxide def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing tert-butyl hydroperoxide (t-BOOH, TBHP)." [PomBase:mah] synonym: "normal cell population growth in presence of tert-butyl hydroperoxide" EXACT [PomBase:mah] synonym: "normal cell population growth on 2-methyl-prop-2-yl-hydroperoxide" EXACT [CHEBI:64090] synonym: "normal cell population growth on tert-butyl hydroperoxide" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to tert-butyl hydroperoxide" RELATED [PomBase:al, PomBase:mah] synonym: "normal growth on t-BOOH" EXACT [PomBase:mah] synonym: "normal growth on TBHP" EXACT [PomBase:mah] synonym: "normal vegetative cell population growth on tert-butyl hydroperoxide" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:64090 ! tert-butyl hydroperoxide relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:64090 ! tert-butyl hydroperoxide created_by: midori creation_date: 2012-07-16T15:28:00Z [Term] id: FYPO:0001240 name: normal growth on diamide def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide, also known as diamide." [PomBase:mah] synonym: "normal cell population growth in presence of diamide" EXACT [PomBase:mah] synonym: "normal cell population growth on diamide" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cell population growth on N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide" EXACT [CHEBI:48958, PomBase:mah] synonym: "normal cellular response to diamide" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on diamide" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:48958 ! 1,1'-azobis(N,N-dimethylformamide) relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:48958 ! 1,1'-azobis(N,N-dimethylformamide) created_by: midori creation_date: 2012-07-16T15:30:45Z [Term] id: FYPO:0001241 name: normal growth on anisomycin def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing anisomycin." [PomBase:mah] synonym: "normal cell population growth in presence of anisomycin" EXACT [PomBase:mah] synonym: "normal cell population growth on anisomycin" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to anisomycin" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on anisomycin" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:338412 ! (-)-anisomycin relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:338412 ! (-)-anisomycin created_by: midori creation_date: 2012-07-16T15:31:50Z [Term] id: FYPO:0001242 name: increased RNA level during cellular response to adenine starvation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to adenine starvation is higher than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased mRNA level during cellular response to adenine starvation" NARROW [PomBase:mah] synonym: "increased RNA accumulation during cellular response to adenine starvation" RELATED [PomBase:mah] synonym: "increased RNA level during cellular response to adenine depletion" EXACT [PomBase:vw] synonym: "increased RNA level during cellular response to adenine deprivation" EXACT [PomBase:vw] synonym: "increased RNA level during cellular response to adenine starvation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased RNA level during cellular response to adenine starvation during vegetative growth" EXACT [PomBase:mah] synonym: "increased transcript level during cellular response to adenine starvation" EXACT [PomBase:vw] is_a: FYPO:0000825 ! increased RNA level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0036223 ! cellular response to adenine starvation intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0036223 ! cellular response to adenine starvation relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2012-07-16T15:56:42Z [Term] id: FYPO:0001243 name: increased RNA level during cellular response to vitamin B1 def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to vitamin B1 is higher than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased mRNA level during cellular response to vitamin B1" NARROW [PomBase:mah] synonym: "increased RNA accumulation during cellular response to vitamin B1" RELATED [PomBase:mah] synonym: "increased RNA level during cellular response to thiamine" EXACT [GO:0071301, PomBase:mah] synonym: "increased RNA level during cellular response to vitamin B1 during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased RNA level during cellular response to vitamin B1 during vegetative growth" EXACT [PomBase:mah] synonym: "increased transcript level during cellular response to vitamin B1" EXACT [PomBase:vw] is_a: FYPO:0000825 ! increased RNA level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0071301 ! cellular response to vitamin B1 intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0071301 ! cellular response to vitamin B1 relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2012-07-16T15:57:59Z [Term] id: FYPO:0001244 name: decreased RNA level during cellular response to vitamin B1 starvation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to vitamin B1 starvation is lower than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased mRNA level during cellular response to vitamin B1 starvation" NARROW [PomBase:mah] synonym: "decreased RNA accumulation during cellular response to vitamin B1 starvation" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to thiamine starvation" EXACT [GO:0036225, PomBase:mah] synonym: "decreased RNA level during cellular response to vitamin B1 depletion" EXACT [PomBase:vw] synonym: "decreased RNA level during cellular response to vitamin B1 deprivation" EXACT [PomBase:vw] synonym: "decreased RNA level during cellular response to vitamin B1 starvation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to vitamin B1 starvation during vegetative growth" EXACT [PomBase:mah] synonym: "decreased transcript level during cellular response to vitamin B1 starvation" EXACT [PomBase:vw] synonym: "reduced RNA level during cellular response to vitamin B1 starvation" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0036225 ! cellular response to vitamin B1 starvation intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0036225 ! cellular response to vitamin B1 starvation relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2012-07-16T16:01:16Z [Term] id: FYPO:0001245 name: sensitive to cobalt def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to cobalt ions." [PomBase:mah] synonym: "hypersensitive to cobalt" EXACT [PomBase:mah] synonym: "sensitive to cobalt during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to cobalt during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to cobalt ions" EXACT [CHEBI:23336] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:48828 ! cobalt(2+) relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:48828 ! cobalt(2+) created_by: midori creation_date: 2012-07-16T16:15:13Z [Term] id: FYPO:0001246 name: normal RNA level during cellular response to hydrogen peroxide def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to hydrogen peroxide is normal (i.e. indistinguishable from wild type). Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [PomBase:mah] comment: We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "normal mRNA level during cellular response to hydrogen peroxide" NARROW [PomBase:mah] synonym: "normal RNA accumulation during cellular response to hydrogen peroxide" RELATED [PomBase:mah] synonym: "normal RNA level during cellular response to H2O2" EXACT [PomBase:mah] synonym: "normal RNA level during cellular response to hydrogen peroxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal RNA level during cellular response to hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001317 ! normal RNA level during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0070301 ! cellular response to hydrogen peroxide intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0070301 ! cellular response to hydrogen peroxide relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2012-07-17T13:17:07Z [Term] id: FYPO:0001248 name: abnormal regulation of mitotic DNA replication initiation def: "A regulation phenotype observed in the vegetative growth phase of the life cycle in which regulation of the initiation of mitotic DNA replication is abnormal." [PomBase:mah] synonym: "abnormal regulation of DNA replication initiation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal regulation of mitotic DNA replication initiation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000148 ! abnormal regulation of mitotic cell cycle is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0004756 ! abnormal regulation of DNA replication initiation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1903466 ! regulation of mitotic DNA replication initiation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1903466 ! regulation of mitotic DNA replication initiation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-07-17T13:25:25Z [Term] id: FYPO:0001249 name: increased origin firing efficiency def: "A regulation phenotype observed in the vegetative growth phase of the life cycle in which the probability that a DNA replication will initiate at a particular replication origin is higher than in wild type. In cells with increased origin firing efficiency, genomic DNA replication initiates from more origins than wild type, and is completed in more, smaller segments, than wild type." [PMID:18799612, PomBase:mah] synonym: "increased origin firing efficiency during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased origin firing efficiency during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001248 ! abnormal regulation of mitotic DNA replication initiation created_by: midori creation_date: 2012-07-17T13:28:55Z [Term] id: FYPO:0001250 name: decreased origin firing efficiency def: "A regulation phenotype observed in the vegetative growth phase of the life cycle in which the probability that a DNA replication will initiate at a particular replication origin is lower than in wild type. In cells with decreased origin firing efficiency, genomic DNA replication initiates from fewer origins than wild type, and is completed in fewer, larger segments, than wild type." [PMID:18799612, PomBase:mah] synonym: "decreased origin firing efficiency during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased origin firing efficiency during vegetative growth" EXACT [PomBase:mah] synonym: "reduced origin firing efficiency" EXACT [PomBase:mah] is_a: FYPO:0001248 ! abnormal regulation of mitotic DNA replication initiation created_by: midori creation_date: 2012-07-17T13:31:48Z [Term] id: FYPO:0001252 name: multinucleate multiseptate vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell has two or more nuclei and more than one septum per cell." [PomBase:mah] synonym: "multinucleate multiseptate cell during vegetative growth" EXACT [PomBase:mah] synonym: "multinucleate multiseptate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000061 ! multinucleate vegetative cell intersection_of: has_part FYPO:0000118 ! multiseptate vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000061 ! multinucleate vegetative cell relationship: has_part FYPO:0000118 ! multiseptate vegetative cell created_by: midori creation_date: 2012-07-19T15:38:21Z [Term] id: FYPO:0001253 name: elongated multinucleate multiseptate vegetative cell, septa between nuclei def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is longer than normal, has two or more nuclei and more than one septum, and the septa are located so as to form separate compartments with a single nucleus in each." [PomBase:mah, PomBase:vw] synonym: "elongated multinucleate multiseptate cell, septa between nuclei during vegetative growth" EXACT [PomBase:mah] synonym: "elongated multinucleate multiseptate vegetative cell, septa between nuclei during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0003343 ! elongated multinucleate multiseptate cell, septa between nuclei created_by: midori creation_date: 2012-07-19T15:40:18Z [Term] id: FYPO:0001254 name: multinucleate multiseptate cell, septa grouped def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell has two or more nuclei and more than one septum, and the septa are grouped together between two compartments, one or more of which may contain multiple nuclei." [PomBase:mah] synonym: "multinucleate multiseptate cell, septa grouped during mitotic cell cycle" RELATED [PomBase:mah] synonym: "multinucleate multiseptate cell, septa grouped during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001252 ! multinucleate multiseptate vegetative cell is_a: FYPO:0002002 ! multiseptate vegetative cell, septa grouped created_by: midori creation_date: 2012-07-19T15:41:59Z [Term] id: FYPO:0001255 name: increased protein level during cellular response to oxygen def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during a cellular response to the level of oxygen is higher than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein accumulation during cellular response to oxygen" RELATED [PomBase:mah] synonym: "increased protein level during cellular response to oxygen during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein level during cellular response to oxygen during vegetative growth" EXACT [PomBase:mah] synonym: "increased protein level during cellular response to oxygen levels" EXACT [GO:0071453] is_a: FYPO:0001327 ! increased protein level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0071453 ! cellular response to oxygen levels intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0071453 ! cellular response to oxygen levels relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2012-07-19T16:01:11Z [Term] id: FYPO:0001256 name: increased protein level during cellular response to hypoxia def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during a cellular response to hypoxia is higher than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein accumulation during cellular response to hypoxia" RELATED [PomBase:mah] synonym: "increased protein level during cellular response to hyperoxic stress" EXACT [GO:0071456] synonym: "increased protein level during cellular response to hypoxia during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein level during cellular response to hypoxia during vegetative growth" EXACT [PomBase:mah] synonym: "increased protein level during cellular response to increased oxygen tension" EXACT [GO:0071456] is_a: FYPO:0001255 ! increased protein level during cellular response to oxygen is_a: FYPO:0001549 ! altered protein level during cellular response to hypoxia intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0071456 ! cellular response to hypoxia intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0071456 ! cellular response to hypoxia relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2012-07-19T16:03:44Z [Term] id: FYPO:0001257 name: normal protein level during cellular response to oxygen def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during a cellular response to the level of oxygen is normal (i.e. indistinguishable from wild type). Total protein or a specific protein may be affected." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein accumulation during cellular response to oxygen" RELATED [PomBase:mah] synonym: "normal protein level during cellular response to oxygen during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein level during cellular response to oxygen during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein level during cellular response to oxygen levels" EXACT [GO:0071453] is_a: FYPO:0000833 ! normal protein level during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0071453 ! cellular response to oxygen levels intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0071453 ! cellular response to oxygen levels relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2012-07-19T16:05:22Z [Term] id: FYPO:0001258 name: normal protein level during cellular response to hypoxia def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during a cellular response to hypoxia is normal (i.e. indistinguishable from wild type). Total protein or a specific protein may be affected." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein accumulation during cellular response to hypoxia" RELATED [PomBase:mah] synonym: "normal protein level during cellular response to hyperoxic stress" EXACT [GO:0071456] synonym: "normal protein level during cellular response to hypoxia during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein level during cellular response to hypoxia during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein level during cellular response to increased oxygen tension" EXACT [GO:0071456] is_a: FYPO:0001257 ! normal protein level during cellular response to oxygen intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0071456 ! cellular response to hypoxia intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0071456 ! cellular response to hypoxia relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2012-07-19T16:06:01Z [Term] id: FYPO:0001259 name: decreased RNA level during cellular response to hypoxia def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to hypoxia is lower than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased RNA accumulation during cellular response to hypoxia" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to hyperoxic stress" EXACT [GO:0071456] synonym: "decreased RNA level during cellular response to hypoxia during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to hypoxia during vegetative growth" EXACT [PomBase:mah] synonym: "decreased RNA level during cellular response to increased oxygen tension" EXACT [GO:0071456] synonym: "decreased transcript level during cellular response to hypoxia" EXACT [PomBase:vw] synonym: "reduced RNA level during cellular response to hypoxia" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0071456 ! cellular response to hypoxia intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0071456 ! cellular response to hypoxia relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2012-07-19T16:07:22Z [Term] id: FYPO:0001260 name: normal RNA level during cellular response to hypoxia def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to hypoxia is normal (i.e. indistinguishable from wild type). Total RNA or a specific RNA may be affected." [PomBase:mah] comment: We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "normal mRNA level during cellular response to hypoxia" NARROW [PomBase:mah] synonym: "normal protein level during cellular response to increased oxygen tension" EXACT [GO:0071456] synonym: "normal RNA accumulation during cellular response to hypoxia" RELATED [PomBase:mah] synonym: "normal RNA level during cellular response to hyperoxic stress" EXACT [GO:0071456] synonym: "normal RNA level during cellular response to hypoxia during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal RNA level during cellular response to hypoxia during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001317 ! normal RNA level during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0071456 ! cellular response to hypoxia intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0071456 ! cellular response to hypoxia relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2012-07-19T16:10:05Z [Term] id: FYPO:0001261 name: decreased cytokinesis during cellular hyperosmotic response def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of mitotic cytokinesis is decreased during a cellular hyperosmotic response." [PomBase:mah] synonym: "decreased cytokinesis during cellular hyperosmotic response during vegetative growth" EXACT [PomBase:mah] synonym: "decreased mitotic cytokinesis" EXACT [GO:0000281, PomBase:mah] synonym: "reduced cytokinesis during cellular hyperosmotic response" EXACT [PomBase:mah] is_a: FYPO:0000418 ! decreased cytokinesis intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0071474 ! cellular hyperosmotic response intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000281 ! mitotic cytokinesis relationship: happens_during GO:0071474 ! cellular hyperosmotic response relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000281 ! mitotic cytokinesis created_by: midori creation_date: 2012-07-19T16:20:14Z [Term] id: FYPO:0001262 name: stubby cell during cellular hyperosmotic response def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which the cell diameter is larger than normal and the cell length is shorter than normal, during a cellular hyperosmotic response." [PomBase:mah] synonym: "stubby cell during cellular hyperosmotic response during mitotic cell cycle" RELATED [PomBase:mah] synonym: "stubby cell during cellular hyperosmotic response during vegetative growth" EXACT [PomBase:mah] synonym: "watermelon-shaped cell during cellular hyperosmotic response" EXACT [PomBase:mah] is_a: FYPO:0000024 ! stubby cell intersection_of: PATO:0001643 ! stubby intersection_of: exists_during GO:0071474 ! cellular hyperosmotic response intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: exists_during GO:0071474 ! cellular hyperosmotic response relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) created_by: midori creation_date: 2012-07-19T16:21:16Z [Term] id: FYPO:0001263 name: branched, elongated cell during cellular hyperosmotic response def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is branched and septated, and longer than normal, during a cellular hyperosmotic response." [PomBase:jh, PomBase:mah] synonym: "branched, elongated cell during cellular hyperosmotic response during mitotic cell cycle" RELATED [PomBase:mah] synonym: "branched, elongated cell during cellular hyperosmotic response during vegetative growth" EXACT [PomBase:mah] synonym: "branched, elongated, septated cell during cellular hyperosmotic response" EXACT [PomBase:vw] is_a: FYPO:0000015 ! branched vegetative cell is_a: FYPO:0004594 ! branched, elongated, septated cell intersection_of: PATO:0000402 ! branched intersection_of: exists_during GO:0071474 ! cellular hyperosmotic response intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: exists_during GO:0071474 ! cellular hyperosmotic response relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) created_by: midori creation_date: 2012-07-19T16:22:02Z [Term] id: FYPO:0001264 name: abnormal cell polarity during cellular hyperosmotic response def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the establishment or maintenance of cell polarity is abnormal during a cellular hyperosmotic response." [PomBase:mah] synonym: "abnormal cell polarity during cellular hyperosmotic response during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal cell polarity during cellular hyperosmotic response during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal establishment or maintenance of cell polarity during cellular hyperosmotic response" EXACT [PomBase:mah] synonym: "cell polarity defects during cellular hyperosmotic response" EXACT [PomBase:mah] is_a: FYPO:0000026 ! abnormal cell polarity intersection_of: PATO:0000001 ! quality intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: happens_during GO:0071474 ! cellular hyperosmotic response intersection_of: inheres_in_part_of GO:0007163 ! establishment or maintenance of cell polarity intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: happens_during GO:0071474 ! cellular hyperosmotic response relationship: inheres_in_part_of GO:0007163 ! establishment or maintenance of cell polarity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-07-19T16:23:32Z [Term] id: FYPO:0001265 name: increased protein phosphorylation during cellular hyperosmotic response def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a greater extent than normal during a cellular hyperosmotic response." [PomBase:mah] synonym: "increased protein phosphorylation during cellular hyperosmotic response during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein phosphorylation during cellular hyperosmotic response during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001038 ! increased protein phosphorylation during vegetative growth intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0071474 ! cellular hyperosmotic response intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0071474 ! cellular hyperosmotic response relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2012-07-19T16:27:02Z [Term] id: FYPO:0001266 name: normal protein phosphorylation during cellular response to salt stress def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins is normal (i.e. indistinguishable from wild type) during a cellular response to salt stress." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein phosphorylation during cellular response to salt stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein phosphorylation during cellular response to salt stress during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000776 ! normal protein phosphorylation during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0071472 ! cellular response to salt stress intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0071472 ! cellular response to salt stress relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-07-19T16:28:13Z [Term] id: FYPO:0001267 name: abolished nuclear export during cellular hypotonic salinity response def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which nuclear export does not occur when the cell is subject to a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment. Nuclear export is the directed movement of any substance out of the nucleus; export of all substances or a specific substance may be affected." [PomBase:mah] synonym: "abolished nuclear export during cellular hypotonic salinity response during mitotic cell cycle" RELATED [PomBase:mah] synonym: "absent nuclear export during cellular hypotonic salinity response" EXACT [PomBase:mah] synonym: "nuclear export during cellular hypotonic salinity response abolished" EXACT [PomBase:mah] synonym: "nuclear export during cellular hypotonic salinity response abolished during vegetative growth" EXACT [PomBase:mah] synonym: "nuclear export in response to salt starvation abolished" EXACT [PomBase:al] is_a: FYPO:0000507 ! abolished nuclear export intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0071477 ! cellular hypotonic salinity response intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0051168 ! nuclear export relationship: during GO:0071477 ! cellular hypotonic salinity response relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0051168 ! nuclear export created_by: midori creation_date: 2012-07-19T16:50:01Z [Term] id: FYPO:0001268 name: abnormal protein localization to kinetochore during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the kinetochore of a chromosome is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found at the kinetochore and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to kinetochore during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal protein localization to kinetochore during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000449 ! abnormal protein localization to centromere intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0034501 ! protein localization to kinetochore intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0034501 ! protein localization to kinetochore relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-07-19T16:53:31Z [Term] id: FYPO:0001269 name: abolished protein localization to kinetochore during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the kinetochore of a chromosome is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to kinetochore during vegetative growth" EXACT [PomBase:mah] synonym: "abolished protein localization to kinetochore during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein localization to kinetochore abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000634 ! abolished protein localization to centromere is_a: FYPO:0001268 ! abnormal protein localization to kinetochore during vegetative growth intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0034501 ! protein localization to kinetochore relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0034501 ! protein localization to kinetochore created_by: midori creation_date: 2012-07-19T16:54:02Z [Term] id: FYPO:0001270 name: complete but unequal mitotic sister chromatid segregation def: "A cellular process phenotype in which mitotic sister chromatid segregation results in the separation of chromosomes into two distinct unequal masses, located at or near the ends of an elongated mitotic spindle." [PMID:22711988, PomBase:mah] synonym: "aneuploidy" RELATED [PomBase:vw] synonym: "complete but unequal mitotic chromosome segregation" EXACT [PomBase:mah] synonym: "complete but unequal mitotic sister chromatid separation" RELATED [PomBase:mah] synonym: "complete but unequal mitotic sister chromatid separation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003241 ! unequal mitotic sister chromatid segregation created_by: midori creation_date: 2012-07-19T17:05:51Z [Term] id: FYPO:0001271 name: incomplete, unequal mitotic sister chromatid segregation def: "A cellular process phenotype in which mitotic sister chromatid segregation stops before completing separation of chromosomes; some, but not all, DNA may be moved towards the ends of an elongated mitotic spindle. Chromosomes do not segregate into two equal masses." [PMID:22711988, PomBase:mah] synonym: "incomplete, unequal mitotic chromosome segregation" EXACT [PomBase:mah] synonym: "incomplete, unequal mitotic sister chromatid segregation during vegetative growth" EXACT [PomBase:mah] synonym: "incomplete, unequal mitotic sister chromatid separation" RELATED [PomBase:mah] is_a: FYPO:0003241 ! unequal mitotic sister chromatid segregation is_a: FYPO:0003757 ! incomplete mitotic sister chromatid segregation created_by: midori creation_date: 2012-07-19T17:09:10Z [Term] id: FYPO:0001272 name: incomplete, unequal mitotic sister chromatid segregation, with smeared DNA def: "A cellular process phenotype in which mitotic sister chromatid segregation stops before completing separation of chromosomes, and DNA becomes spread into an indistinct mass along much of the length of the mitotic spindle." [PMID:22711988, PomBase:mah] synonym: "incomplete, unequal mitotic sister chromatid segregation, with smeared DNA during vegetative growth" EXACT [PomBase:mah] synonym: "incomplete, unequal mitotic sister chromatid separation, with smeared DNA" RELATED [PomBase:mah] is_a: FYPO:0001271 ! incomplete, unequal mitotic sister chromatid segregation created_by: midori creation_date: 2012-07-19T17:15:07Z [Term] id: FYPO:0001273 name: incomplete, unequal mitotic sister chromatid segregation, with unseparated DNA def: "A cellular process phenotype in which mitotic sister chromatid segregation stops before completing separation of chromosomes, and DNA remains in a single mass at or near the midpoint of the mitotic spindle." [PMID:22711988, PomBase:mah] synonym: "incomplete, unequal mitotic sister chromatid segregation, with unseparated DNA during vegetative growth" EXACT [PomBase:mah] synonym: "incomplete, unequal mitotic sister chromatid separation, with unseparated DNA" RELATED [PomBase:mah] is_a: FYPO:0001271 ! incomplete, unequal mitotic sister chromatid segregation is_a: FYPO:0003758 ! incomplete mitotic sister chromatid segregation, with unseparated DNA created_by: midori creation_date: 2012-07-19T17:15:33Z [Term] id: FYPO:0001274 name: decreased protein level during cellular response to hypoxia def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during a cellular response to hypoxia is lower than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein accumulation during cellular response to hypoxia" RELATED [PomBase:mah] synonym: "decreased protein level during cellular response to hypoxia during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein level during cellular response to hypoxia during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein level during cellular response to hypoxic stress" EXACT [GO:0071456] synonym: "decreased protein level during cellular response to lowered oxygen tension" EXACT [GO:0071456] synonym: "reduced protein level during cellular response to hypoxia" EXACT [PomBase:mah] is_a: FYPO:0001324 ! decreased protein level during vegetative growth is_a: FYPO:0001549 ! altered protein level during cellular response to hypoxia intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0071456 ! cellular response to hypoxia intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0071456 ! cellular response to hypoxia relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2012-07-19T17:21:36Z [Term] id: FYPO:0001275 name: decreased protein binding during cellular response to hypoxia def: "A molecular function phenotype in which the binding of one protein to another occurs to a lower extent than normal during a cellular response to hypoxia. The relevant proteins may include the one encoded by the mutated gene, or may both be encoded by different genes." [PomBase:mah] comment: This term can be used for any protein-protein interaction that is affected by a mutation, whether or not the mutated gene product is one of the interacting proteins. We recommend noting which proteins were used in the assay when annotating to this term. synonym: "decreased protein binding in response to hypoxia" RELATED [PomBase:al] synonym: "decreased protein-protein interaction during cellular response to hypoxia" EXACT [PomBase:mah] synonym: "reduced protein binding during cellular response to hypoxia" EXACT [PomBase:mah] is_a: FYPO:0001645 ! decreased protein binding intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0071456 ! cellular response to hypoxia intersection_of: inheres_in GO:0005515 ! protein binding relationship: happens_during GO:0071456 ! cellular response to hypoxia relationship: inheres_in GO:0005515 ! protein binding created_by: midori creation_date: 2012-07-19T17:23:30Z [Term] id: FYPO:0001276 name: decreased MCM complex assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of MCM complex assembly is decreased." [PomBase:mah] synonym: "decreased MCM complex assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased MCM complex assembly during vegetative growth" EXACT [PomBase:mah] synonym: "reduced MCM complex assembly" EXACT [PomBase:mah] is_a: FYPO:0000448 ! abnormal MCM complex assembly is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072689 ! MCM complex assembly relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072689 ! MCM complex assembly created_by: midori creation_date: 2012-07-20T17:32:31Z [Term] id: FYPO:0001277 name: abolished MCM complex assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which MCM complex assembly is abolished." [PomBase:mah] synonym: "abolished MCM complex assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished MCM complex assembly during vegetative growth" EXACT [PomBase:mah] synonym: "MCM complex assembly abolished" EXACT [PomBase:mah] is_a: FYPO:0000448 ! abnormal MCM complex assembly is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0072689 ! MCM complex assembly relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0072689 ! MCM complex assembly created_by: midori creation_date: 2012-07-20T17:34:14Z [Term] id: FYPO:0001278 name: normal MCM complex assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which MCM complex assembly is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal MCM complex assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal MCM complex assembly during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001215 ! normal protein complex assembly intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072689 ! MCM complex assembly intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072689 ! MCM complex assembly relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-07-20T17:36:38Z [Term] id: FYPO:0001279 name: increased RNA level during cellular response to oxidative stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to oxidative stress is higher than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased mRNA level during cellular response to oxidative stress" NARROW [PomBase:mah] synonym: "increased RNA accumulation during cellular response to oxidative stress" RELATED [PomBase:mah] synonym: "increased RNA level during cellular response to oxidative stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased RNA level during cellular response to oxidative stress during vegetative growth" EXACT [PomBase:mah] synonym: "increased transcript level during cellular response to oxidative stress" EXACT [PomBase:vw] is_a: FYPO:0000825 ! increased RNA level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0034599 ! cellular response to oxidative stress intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0034599 ! cellular response to oxidative stress relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2012-07-26T10:59:25Z [Term] id: FYPO:0001280 name: decreased RNA level during cellular response to oxidative stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to oxidative stress is lower than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased mRNA level during cellular response to oxidative stress" NARROW [PomBase:mah] synonym: "decreased RNA accumulation during cellular response to oxidative stress" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to DEM" NARROW [PomBase:al] synonym: "decreased RNA level during cellular response to diethyl maleate" NARROW [PomBase:mah] synonym: "decreased RNA level during cellular response to oxidative stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to oxidative stress during vegetative growth" EXACT [PomBase:mah] synonym: "decreased transcript level during cellular response to oxidative stress" EXACT [PomBase:vw] synonym: "reduced RNA level during cellular response to oxidative stress" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0034599 ! cellular response to oxidative stress intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0034599 ! cellular response to oxidative stress relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2012-07-26T11:06:41Z [Term] id: FYPO:0001281 name: normal protein phosphorylation during cellular response to hydrogen peroxide def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins is normal (i.e. indistinguishable from wild type) a cellular response to hydrogen peroxide." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein phosphorylation during cellular response to H2O2" EXACT [PomBase:mah] synonym: "normal protein phosphorylation during cellular response to hydrogen peroxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein phosphorylation during cellular response to hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000776 ! normal protein phosphorylation during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0070301 ! cellular response to hydrogen peroxide intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0070301 ! cellular response to hydrogen peroxide relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-07-26T11:15:18Z [Term] id: FYPO:0001282 name: abnormal chromatin organization during nitrogen starvation def: "A cellular process phenotype in which any process of chromatin organization is abnormal when the cell is subject to nitrogen starvation. Chromatin organization results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GO:0006325, PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "abnormal chromatin organisation during nitrogen starvation" EXACT [PomBase:mah] synonym: "abnormal chromatin organization during nitrogen depletion" EXACT [PomBase:vw] synonym: "abnormal chromatin organization during nitrogen deprivation" EXACT [PomBase:vw] is_a: FYPO:0000642 ! abnormal chromatin organization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in_part_of GO:0006325 ! chromatin organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in_part_of GO:0006325 ! chromatin organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-07-26T11:50:10Z [Term] id: FYPO:0001283 name: decreased protein level during cellular response to nitrogen starvation def: "A cell phenotype in which the amount of protein measured in a cell during a cellular response to nitrogen starvation is lower than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein accumulation during cellular response to nitrogen starvation" RELATED [PomBase:mah] synonym: "decreased protein level during cellular response to nitrogen depletion" EXACT [PomBase:vw] synonym: "decreased protein level during cellular response to nitrogen deprivation" EXACT [PomBase:vw] synonym: "decreased protein level during nitrogen starvation" EXACT [PomBase:mah] synonym: "reduced protein level during cellular response to nitrogen starvation" EXACT [PomBase:mah] is_a: FYPO:0000835 ! decreased protein level is_a: FYPO:0004139 ! altered level of substance in cell during nitrogen starvation intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2012-07-26T11:59:16Z [Term] id: FYPO:0001284 name: phosphatidylserine absent from cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of phosphatidylserine measured in a cell is too low to detect." [PomBase:mah] synonym: "phosphatidyl-L-serine absent from cell" EXACT [CHEBI:18303] synonym: "phosphatidylserine absent from cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "phosphatidylserine absent from cell during vegetative growth" EXACT [PomBase:mah] synonym: "PS absent from cell" EXACT [PomBase:mah] is_a: FYPO:0001208 ! substance absent from cell during vegetative growth is_a: FYPO:0001289 ! decreased phospholipid level intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:18303 ! phosphatidyl-L-serine relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:18303 ! phosphatidyl-L-serine created_by: midori creation_date: 2012-07-26T12:20:15Z [Term] id: FYPO:0001285 name: decreased cellular phosphatidylethanolamine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of phosphatidylethanolamine measured in a cell is lower than normal." [PomBase:mah] synonym: "decreased cellular PE level" EXACT [PomBase:mah] synonym: "decreased cellular phosphatidylethanolamine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular phosphatidylethanolamine level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased phosphatidylethanolamine accumulation" RELATED [PomBase:al] synonym: "reduced cellular phosphatidylethanolamine level" EXACT [PomBase:mah] is_a: FYPO:0001289 ! decreased phospholipid level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:16038 ! phosphatidylethanolamine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:16038 ! phosphatidylethanolamine created_by: midori creation_date: 2012-07-26T12:25:19Z [Term] id: FYPO:0001286 name: increased cellular phosphoinositide level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of a phosphoinositide measured in a cell is higher than normal. A phosphoinositide is any phosphatidylinositol that is phosphorylated at one or more of the hydroxy groups of inositol." [PomBase:mah] synonym: "increased cellular phosphoinositide level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular phosphoinositide level during vegetative growth" EXACT [PomBase:mah] synonym: "increased cellular PI level" RELATED [PomBase:al] synonym: "increased PI accumulation" RELATED [PomBase:al] is_a: FYPO:0001288 ! increased phospholipid level is_a: FYPO:0001290 ! altered cellular phosphoinositide level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:18179 ! phosphoinositide relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:18179 ! phosphoinositide created_by: midori creation_date: 2012-07-26T12:26:35Z [Term] id: FYPO:0001287 name: altered phospholipid level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of a phospholipid measured in a cell differs from normal. A phospholipid is any lipid containing phosphoric acid as a mono- or di-ester." [CHEBI:16247, PomBase:mah] synonym: "abnormal phospholipid level" EXACT [PomBase:mah] synonym: "altered cellular phospholipid level" EXACT [PomBase:mah] synonym: "altered phospholipid level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "altered phospholipid level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001323 ! altered level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:16247 ! phospholipid relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:16247 ! phospholipid created_by: midori creation_date: 2012-07-26T13:16:37Z [Term] id: FYPO:0001288 name: increased phospholipid level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of a phospholipid measured in a cell is higher than normal. A phospholipid is any lipid containing phosphoric acid as a mono- or di-ester." [CHEBI:16247, PomBase:mah] synonym: "increased cellular phospholipid level" EXACT [PomBase:mah] synonym: "increased phospholipid accumulation" RELATED [PomBase:mah] synonym: "increased phospholipid level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased phospholipid level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001287 ! altered phospholipid level is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:16247 ! phospholipid relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:16247 ! phospholipid created_by: midori creation_date: 2012-07-26T13:21:43Z [Term] id: FYPO:0001289 name: decreased phospholipid level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of a phospholipid measured in a cell is lower than normal. A phospholipid is any lipid containing phosphoric acid as a mono- or di-ester." [CHEBI:16247, PomBase:mah] synonym: "decreased cellular phospholipid level" EXACT [PomBase:mah] synonym: "decreased phospholipid accumulation" RELATED [PomBase:mah] synonym: "decreased phospholipid level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased phospholipid level during vegetative growth" EXACT [PomBase:mah] synonym: "reduced phospholipid level" EXACT [PomBase:mah] is_a: FYPO:0001287 ! altered phospholipid level is_a: FYPO:0001329 ! decreased level of substance in cell during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:16247 ! phospholipid relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:16247 ! phospholipid created_by: midori creation_date: 2012-07-26T13:22:15Z [Term] id: FYPO:0001290 name: altered cellular phosphoinositide level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of a phosphoinositide measured in a cell differs from normal. A phosphoinositide is any phosphatidylinositol that is phosphorylated at one or more of the hydroxy groups of inositol." [PomBase:mah] synonym: "abnormal cellular phosphoinositide level" EXACT [PomBase:mah] synonym: "altered cellular phosphoinositide level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "altered cellular phosphoinositide level during vegetative growth" EXACT [PomBase:mah] synonym: "altered cellular PI level" RELATED [PomBase:al] synonym: "altered PI accumulation" RELATED [PomBase:al] is_a: FYPO:0001287 ! altered phospholipid level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:18179 ! phosphoinositide relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:18179 ! phosphoinositide created_by: midori creation_date: 2012-07-26T13:23:26Z [Term] id: FYPO:0001291 name: abnormal CDP-diacylglycerol-serine O-phosphatidyltransferase activity def: "A molecular function phenotype in which the observed rate of CDP-diacylglycerol-serine O-phosphatidyltransferase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0003882 ! CDP-diacylglycerol-serine O-phosphatidyltransferase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0003882 ! CDP-diacylglycerol-serine O-phosphatidyltransferase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-07-26T13:33:37Z [Term] id: FYPO:0001292 name: decreased CDP-diacylglycerol-serine O-phosphatidyltransferase activity def: "A molecular function phenotype in which the observed rate of CDP-diacylglycerol-serine O-phosphatidyltransferase activity is decreased." [PomBase:mah] synonym: "reduced CDP-diacylglycerol-serine O-phosphatidyltransferase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0001291 ! abnormal CDP-diacylglycerol-serine O-phosphatidyltransferase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0003882 ! CDP-diacylglycerol-serine O-phosphatidyltransferase activity relationship: inheres_in GO:0003882 ! CDP-diacylglycerol-serine O-phosphatidyltransferase activity created_by: midori creation_date: 2012-07-26T13:34:04Z [Term] id: FYPO:0001293 name: normal cell wall biogenesis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which cell wall biogenesis is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cell wall biogenesis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cell wall biogenesis during vegetative growth" EXACT [PomBase:mah] synonym: "normal fungal-type cell wall biogenesis" EXACT [PomBase:mah] is_a: FYPO:0001319 ! normal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0009272 ! fungal-type cell wall biogenesis intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0009272 ! fungal-type cell wall biogenesis relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-07-26T13:49:47Z [Term] id: FYPO:0001294 name: normal actin cortical patch localization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which actin cortical patch localization is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal actin cortical patch localisation" EXACT [PomBase:mah] synonym: "normal actin cortical patch localization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal actin cortical patch localization during vegetative growth" EXACT [PomBase:mah] synonym: "normal actin cortical patch location" RELATED [PomBase:mah] is_a: FYPO:0001319 ! normal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051666 ! actin cortical patch localization intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051666 ! actin cortical patch localization relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-07-26T14:12:03Z [Term] id: FYPO:0001295 name: normal palmitoyl-CoA ligase activity def: "A molecular function phenotype in which the observed rate of palmitoyl-CoA ligase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal palmitoyl-CoA synthetase activity" EXACT [GO:0090433, PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0090433 ! palmitoyl-CoA ligase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0090433 ! palmitoyl-CoA ligase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-07-26T14:25:18Z [Term] id: FYPO:0001296 name: normal oleoyl-CoA ligase activity def: "A molecular function phenotype in which the observed rate of oleoyl-CoA ligase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal oleoyl-CoA synthetase activity" EXACT [GO:0090434, PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0090434 ! oleoyl-CoA ligase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0090434 ! oleoyl-CoA ligase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-07-26T14:31:43Z [Term] id: FYPO:0001297 name: abnormal palmitoyl-CoA ligase activity def: "A molecular function phenotype in which the observed rate of palmitoyl-CoA ligase activity is abnormal." [PomBase:mah] synonym: "abnormal palmitoyl-CoA synthetase activity" EXACT [GO:0090433, PomBase:mah] is_a: FYPO:0001305 ! abnormal long-chain fatty acid-CoA ligase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0090433 ! palmitoyl-CoA ligase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0090433 ! palmitoyl-CoA ligase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-07-26T14:33:36Z [Term] id: FYPO:0001298 name: decreased palmitoyl-CoA ligase activity def: "A molecular function phenotype in which the observed rate of palmitoyl-CoA ligase activity is decreased." [PomBase:mah] synonym: "decreased palmitoyl-CoA synthetase activity" EXACT [GO:0090433, PomBase:mah] synonym: "reduced palmitoyl-CoA ligase activity" EXACT [PomBase:al] is_a: FYPO:0001297 ! abnormal palmitoyl-CoA ligase activity is_a: FYPO:0001307 ! decreased long-chain fatty acid-CoA ligase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0090433 ! palmitoyl-CoA ligase activity relationship: inheres_in GO:0090433 ! palmitoyl-CoA ligase activity created_by: midori creation_date: 2012-07-26T14:34:05Z [Term] id: FYPO:0001299 name: abolished palmitoyl-CoA ligase activity def: "A molecular function phenotype in which palmitoyl-CoA ligase activity is absent." [PomBase:mah] synonym: "abolished palmitoyl-CoA synthetase activity" EXACT [GO:0090433, PomBase:mah] synonym: "palmitoyl-CoA ligase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0001297 ! abnormal palmitoyl-CoA ligase activity is_a: FYPO:0001306 ! abolished long-chain fatty acid-CoA ligase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0090433 ! palmitoyl-CoA ligase activity relationship: towards GO:0090433 ! palmitoyl-CoA ligase activity created_by: midori creation_date: 2012-07-26T14:34:26Z [Term] id: FYPO:0001300 name: abnormal oleoyl-CoA ligase activity def: "A molecular function phenotype in which the observed rate of oleoyl-CoA ligase activity is abnormal." [PomBase:mah] synonym: "abnormal oleoyl-CoA synthetase activity" EXACT [GO:0090434, PomBase:mah] is_a: FYPO:0001305 ! abnormal long-chain fatty acid-CoA ligase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0090434 ! oleoyl-CoA ligase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0090434 ! oleoyl-CoA ligase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-07-26T14:38:21Z [Term] id: FYPO:0001301 name: abolished oleoyl-CoA ligase activity def: "A molecular function phenotype in which oleoyl-CoA ligase activity is absent." [PomBase:mah] synonym: "abolished oleoyl-CoA synthetase activity" EXACT [GO:0090434, PomBase:mah] synonym: "oleoyl-CoA ligase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0001300 ! abnormal oleoyl-CoA ligase activity is_a: FYPO:0001306 ! abolished long-chain fatty acid-CoA ligase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0090434 ! oleoyl-CoA ligase activity relationship: towards GO:0090434 ! oleoyl-CoA ligase activity created_by: midori creation_date: 2012-07-26T14:38:28Z [Term] id: FYPO:0001302 name: decreased oleoyl-CoA ligase activity def: "A molecular function phenotype in which the observed rate of oleoyl-CoA ligase activity is decreased." [PomBase:mah] synonym: "decreased oleoyl-CoA synthetase activity" RELATED [GO:0090434, PomBase:mah] synonym: "reduced oleoyl-CoA ligase activity" EXACT [PomBase:al] is_a: FYPO:0001300 ! abnormal oleoyl-CoA ligase activity is_a: FYPO:0001307 ! decreased long-chain fatty acid-CoA ligase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0090434 ! oleoyl-CoA ligase activity relationship: inheres_in GO:0090434 ! oleoyl-CoA ligase activity created_by: midori creation_date: 2012-07-26T14:38:38Z [Term] id: FYPO:0001303 name: abnormal myristoyl-CoA ligase activity def: "A molecular function phenotype in which the observed rate of myristoyl-CoA ligase activity is abnormal." [PomBase:mah] synonym: "abnormal myristoyl-CoA synthetase activity" EXACT [GO:0090432, PomBase:mah] is_a: FYPO:0001305 ! abnormal long-chain fatty acid-CoA ligase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0090432 ! myristoyl-CoA ligase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0090432 ! myristoyl-CoA ligase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-07-26T14:40:40Z [Term] id: FYPO:0001304 name: decreased myristoyl-CoA ligase activity def: "A molecular function phenotype in which the observed rate of myristoyl-CoA ligase activity is decreased." [PomBase:mah] synonym: "decreased myristoyl-CoA synthetase activity" RELATED [GO:0090432, PomBase:mah] synonym: "reduced myristoyl-CoA ligase activity" EXACT [PomBase:al] is_a: FYPO:0001303 ! abnormal myristoyl-CoA ligase activity is_a: FYPO:0001307 ! decreased long-chain fatty acid-CoA ligase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0090432 ! myristoyl-CoA ligase activity relationship: inheres_in GO:0090432 ! myristoyl-CoA ligase activity created_by: midori creation_date: 2012-07-26T14:40:44Z [Term] id: FYPO:0001305 name: abnormal long-chain fatty acid-CoA ligase activity def: "A molecular function phenotype in which the observed rate of any long-chain fatty acid-CoA ligase activity is abnormal." [PomBase:mah] synonym: "abnormal lcfa-ligase activity" EXACT [PomBase:al] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004467 ! long-chain fatty acid-CoA ligase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004467 ! long-chain fatty acid-CoA ligase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-07-26T14:44:02Z [Term] id: FYPO:0001306 name: abolished long-chain fatty acid-CoA ligase activity def: "A molecular function phenotype in which long-chain fatty acid-CoA ligase activity is absent." [PomBase:mah] synonym: "abolished lcfa-ligase activity" EXACT [PomBase:al] synonym: "long-chain fatty acid-CoA ligase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0001305 ! abnormal long-chain fatty acid-CoA ligase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0004467 ! long-chain fatty acid-CoA ligase activity relationship: towards GO:0004467 ! long-chain fatty acid-CoA ligase activity created_by: midori creation_date: 2012-07-26T14:45:16Z [Term] id: FYPO:0001307 name: decreased long-chain fatty acid-CoA ligase activity def: "A molecular function phenotype in which the observed rate of long-chain fatty acid-CoA ligase activity is decreased." [PomBase:mah] synonym: "decreased lcfa-ligase activity" EXACT [PomBase:al] synonym: "reduced long-chain fatty acid-CoA ligase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0001305 ! abnormal long-chain fatty acid-CoA ligase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004467 ! long-chain fatty acid-CoA ligase activity relationship: inheres_in GO:0004467 ! long-chain fatty acid-CoA ligase activity created_by: midori creation_date: 2012-07-26T14:45:21Z [Term] id: FYPO:0001308 name: increased long-chain fatty acid-CoA ligase activity def: "A molecular function phenotype in which the observed rate of long-chain fatty acid-CoA ligase activity is increased." [PomBase:mah] synonym: "increased lcfa-ligase activity" EXACT [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0001305 ! abnormal long-chain fatty acid-CoA ligase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0004467 ! long-chain fatty acid-CoA ligase activity relationship: inheres_in GO:0004467 ! long-chain fatty acid-CoA ligase activity created_by: midori creation_date: 2012-07-26T14:45:26Z [Term] id: FYPO:0001309 name: increased viability in stationary phase def: "A cell population phenotype in which a larger than normal proportion of the population remains viable after entering stationary phase." [PomBase:mah] synonym: "increased cell population viability in stationary phase" EXACT [PomBase:mah] is_a: FYPO:0001985 ! abnormal phenotype is_a: FYPO:0002057 ! cell population viability created_by: midori creation_date: 2012-07-26T14:58:27Z [Term] id: FYPO:0001310 name: normal viability in stationary phase def: "A cell population phenotype in which a normal proportion of the population remains viable after entering stationary phase." [PomBase:mah] synonym: "normal cell population viability in stationary phase" EXACT [PomBase:mah] is_a: FYPO:0000257 ! normal phenotype is_a: FYPO:0002057 ! cell population viability created_by: midori creation_date: 2012-07-26T14:59:20Z [Term] id: FYPO:0001311 name: decreased plasmid loss def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which plasmids are lost at a lower frequency than normal. Plasmid loss occurs when one or both daughter cells do not inherit copies of a plasmid from the mother cell, and may result from failure of plasmid replication or segregation." [PomBase:mah] synonym: "decreased plasmid loss during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased plasmid loss during vegetative growth" EXACT [PomBase:mah] synonym: "reduced plasmid loss" EXACT [PomBase:mah] is_a: FYPO:0001320 ! vegetative cell phenotype is_a: FYPO:0003037 ! abnormal cell phenotype created_by: midori creation_date: 2012-07-26T15:11:43Z [Term] id: FYPO:0001312 name: normal vegetative phenotype def: "A normal phenotype that is observed when cells are in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "fission yeast normal vegetative phenotype" EXACT [PomBase:mah] is_a: FYPO:0000257 ! normal phenotype created_by: midori creation_date: 2012-08-01T11:18:45Z [Term] id: FYPO:0001313 name: normal subcellular component during vegetative growth def: "A cell phenotype in which the amount, distribution, or morphology of a cell part is normal (i.e. indistinguishable from wild type) when the cell is in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "normal subcellular component during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal subcellular structure during vegetative growth" RELATED [PomBase:mah] is_a: FYPO:0001233 ! normal subcellular component is_a: FYPO:0001321 ! cellular physical quality phenotype during vegetative growth intersection_of: PATO:0001241 ! physical object quality intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0044464 ! cell part intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0044464 ! cell part relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-08-01T12:32:26Z [Term] id: FYPO:0001314 name: normal cell cortex morphology during vegetative growth def: "A physical cellular phenotype in which the size, shape, and structure of the cell cortex are normal when the cell is in the vegetative growth phase of the life cycle. The cell cortex is the region of a cell that lies just beneath the plasma membrane." [GO:0005938, PomBase:mah] synonym: "normal cell cortex morphology during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001231 ! normal cell cortex morphology is_a: FYPO:0001313 ! normal subcellular component during vegetative growth intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005938 ! cell cortex intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005938 ! cell cortex relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-08-01T12:33:02Z [Term] id: FYPO:0001315 name: normal vegetative cell morphology def: "A cell phenotype characterized by normal cell morphology (i.e. size, shape, and structure) when the cell is in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "normal cell morphology during vegetative growth" EXACT [PomBase:mah] synonym: "normal vegetative cell morphology during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000672 ! normal cell morphology is_a: FYPO:0001312 ! normal vegetative phenotype is_a: FYPO:0001321 ! cellular physical quality phenotype during vegetative growth intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-08-01T13:09:00Z [Term] id: FYPO:0001316 name: normal level of substance in cell during vegetative growth def: "A cell phenotype in which the amount of a specific substance measured in a cell is normal when the cell is in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "normal level of substance in cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001076 ! normal level of substance in cell is_a: FYPO:0001312 ! normal vegetative phenotype is_a: FYPO:0001321 ! cellular physical quality phenotype during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:24431 ! chemical entity relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:24431 ! chemical entity created_by: midori creation_date: 2012-08-01T13:14:57Z [Term] id: FYPO:0001317 name: normal RNA level during vegetative growth def: "A cell phenotype in which the amount of RNA measured in a cell is normal when the cell is in the vegetative growth phase of the life cycle. Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [PomBase:mah] comment: We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "normal cellular RNA level during vegetative growth" EXACT [PomBase:mah] synonym: "normal RNA level during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000840 ! normal RNA level is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2012-08-01T13:15:43Z [Term] id: FYPO:0001318 name: normal cellular response to chemical stimulus during vegetative growth def: "A cellular response phenotype in which the cellular response to a chemical stimulus is normal in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "normal cellular response to chemical stimulus during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000953 ! normal cellular response to chemical stimulus is_a: FYPO:0001319 ! normal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0070887 ! cellular response to chemical stimulus intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0070887 ! cellular response to chemical stimulus relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-08-01T13:37:42Z [Term] id: FYPO:0001319 name: normal cellular process during vegetative growth def: "A phenotype in which a specific cellular process is normal (i.e. indistinguishable from wild type) in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "normal cellular process during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000627 ! normal cellular process is_a: FYPO:0001312 ! normal vegetative phenotype is_a: FYPO:0001331 ! cellular process phenotype during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0044763 ! single-organism cellular process intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0044763 ! single-organism cellular process relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-08-01T13:42:47Z [Term] id: FYPO:0001320 name: vegetative cell phenotype def: "A phenotype that is observed at the level of an individual cell, when the cell is in the vegetative growth phase of the cell cycle." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "cell phenotype during vegetative growth" EXACT [PomBase:mah] synonym: "fission yeast vegetative cell phenotype" EXACT [PomBase:mah] synonym: "vegetative cell phenotype during mitotic cell cycle" RELATED [PomBase:mah] synonym: "vegetative cell phenotype during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase created_by: midori creation_date: 2012-08-01T13:52:18Z [Term] id: FYPO:0001321 name: cellular physical quality phenotype during vegetative growth def: "A phenotype that affects any physical object quality, such as morphology, number, location, etc., of a cell or a cellular component in the vegetative growth phase of the life cycle." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "cellular physical object quality phenotype during vegetative growth" EXACT [PATO:0001241] synonym: "cellular physical quality phenotype during mitotic cell cycle" RELATED [PomBase:mah] synonym: "fission yeast cellular physical object quality phenotype during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000136 ! cellular physical quality phenotype is_a: FYPO:0001320 ! vegetative cell phenotype intersection_of: PATO:0001241 ! physical object quality intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0005575 ! cellular_component relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0005575 ! cellular_component created_by: midori creation_date: 2012-08-01T14:44:55Z [Term] id: FYPO:0001322 name: abnormal subcellular component during vegetative growth def: "A physical cellular phenotype in which the amount, distribution, or morphology of a cell part is abnormal in the vegetative growth phase of the life cycle." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "abnormal subcellular component during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal subcellular structure during vegetative growth" RELATED [PomBase:mah] is_a: FYPO:0000287 ! abnormal subcellular component is_a: FYPO:0004639 ! abnormal cellular physical quality phenotype during vegetative growth intersection_of: PATO:0001241 ! physical object quality intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0044464 ! cell part intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0044464 ! cell part relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-01T14:46:27Z [Term] id: FYPO:0001323 name: altered level of substance in cell during vegetative growth def: "A cell phenotype in which the amount of a specific substance measured in a cell differs from normal when the cell is in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "abnormal level of substance in cell during vegetative growth" EXACT [PomBase:mah] synonym: "altered level of substance in cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000989 ! altered level of substance in cell is_a: FYPO:0004639 ! abnormal cellular physical quality phenotype during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:24431 ! chemical entity relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:24431 ! chemical entity created_by: midori creation_date: 2012-08-01T14:57:41Z [Term] id: FYPO:0001324 name: decreased protein level during vegetative growth def: "A cell phenotype in which the amount of protein measured in a cell is lower than normal when the cell is in the vegetative growth phase of the life cycle. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein accumulation during vegetative growth" RELATED [PomBase:mah] synonym: "decreased protein level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "reduced protein level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000835 ! decreased protein level is_a: FYPO:0001325 ! altered protein level during vegetative growth is_a: FYPO:0001329 ! decreased level of substance in cell during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2012-08-01T15:37:56Z [Term] id: FYPO:0001325 name: altered protein level during vegetative growth def: "A cell phenotype in which the amount of protein measured in a cell differs from normal when the cell is in the vegetative growth phase of the life cycle. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. synonym: "abnormal protein level during vegetative growth" EXACT [PomBase:mah] synonym: "altered cellular protein level during vegetative growth" EXACT [PomBase:mah] synonym: "altered protein level during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000834 ! altered protein level is_a: FYPO:0001323 ! altered level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2012-08-01T15:11:16Z [Term] id: FYPO:0001326 name: altered RNA level during vegetative growth def: "A cell phenotype in which the amount of RNA measured in a cell differs from normal when the cell is in the vegetative growth phase of the life cycle. Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "abnormal RNA level during vegetative growth" EXACT [PomBase:mah] synonym: "altered cellular RNA level during vegetative growth" EXACT [PomBase:mah] synonym: "altered RNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "altered transcript level during vegetative growth" EXACT [PomBase:vw] is_a: FYPO:0000824 ! altered RNA level is_a: FYPO:0001323 ! altered level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2012-08-01T15:11:33Z [Term] id: FYPO:0001327 name: increased protein level during vegetative growth alt_id: FYPO:0000762 def: "A cell phenotype in which the amount of protein measured in a cell is higher than normal when the cell is in the vegetative growth phase of the life cycle. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein accumulation during vegetative growth" RELATED [PomBase:mah] synonym: "increased protein level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein accumulation during vegetative growth" RELATED [PomBase:mah] is_a: FYPO:0000836 ! increased protein level is_a: FYPO:0001325 ! altered protein level during vegetative growth is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2012-08-01T15:43:39Z [Term] id: FYPO:0001328 name: abnormal cytoskeleton organization during vegetative growth def: "A cellular process phenotype in which cytoskeleton organization is abnormal in the vegetative growth phase of the cell cycle." [GO:0007010, PomBase:mah] comment: Consider annotating to 'abnormal cytoskeleton' (FYPO:0002397), but note that an abnormal cytoskeleton organization process may, but does not necessarily, result in a physically abnormal cytoskeleton. synonym: "abnormal cytoskeleton organisation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal cytoskeleton organization during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000802 ! abnormal cytoskeleton organization is_a: FYPO:0001353 ! abnormal cellular component organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0007010 ! cytoskeleton organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0007010 ! cytoskeleton organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-02T17:17:46Z [Term] id: FYPO:0001329 name: decreased level of substance in cell during vegetative growth def: "A cell phenotype in which the amount of a specific substance measured in a cell is lower than normal when the cell is in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "decreased level of substance in cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "reduced level of substance in cell during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000991 ! decreased level of substance in cell is_a: FYPO:0001323 ! altered level of substance in cell during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:24431 ! chemical entity relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:24431 ! chemical entity created_by: midori creation_date: 2012-08-01T16:23:22Z [Term] id: FYPO:0001330 name: increased level of substance in cell during vegetative growth def: "A cell phenotype in which the amount of a specific substance measured in a cell is higher than normal when the cell is in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "increased accumulation of substance in cell during vegetative growth" RELATED [PomBase:mah] synonym: "increased level of substance in cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000990 ! increased level of substance in cell is_a: FYPO:0001323 ! altered level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:24431 ! chemical entity relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:24431 ! chemical entity created_by: midori creation_date: 2012-08-01T16:24:14Z [Term] id: FYPO:0001331 name: cellular process phenotype during vegetative growth def: "A phenotype that affects a cellular process in the vegetative growth phase of the life cycle." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "cellular process phenotype during mitotic cell cycle" RELATED [PomBase:mah] synonym: "fission yeast cellular process phenotype during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000114 ! cellular process phenotype is_a: FYPO:0001320 ! vegetative cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0044763 ! single-organism cellular process relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0044763 ! single-organism cellular process created_by: midori creation_date: 2012-08-01T16:27:01Z [Term] id: FYPO:0001332 name: abnormal regulation of translation in response to stress during vegetative growth def: "A gene expression phenotype in which regulation of translation in response to stress is abnormal in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "abnormal regulation of translation in response to stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein synthesis after stress, defective during vegetative growth" RELATED [PomBase:mah] is_a: FYPO:0000263 ! abnormal regulation of translation in response to stress is_a: FYPO:0001333 ! gene expression regulation phenotype during vegetative growth is_a: FYPO:0001341 ! abnormal cellular response to stress during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0043555 ! regulation of translation in response to stress intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0043555 ! regulation of translation in response to stress relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-01T16:31:58Z [Term] id: FYPO:0001333 name: gene expression regulation phenotype during vegetative growth def: "A regulation phenotype that affects the regulation of gene expression in the vegetative growth phase of the life cycle." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast gene expression regulation phenotype during vegetative growth" EXACT [PomBase:mah] synonym: "gene expression regulation phenotype during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000288 ! gene expression regulation phenotype is_a: FYPO:0001334 ! regulation phenotype during vegetative growth intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0010468 ! regulation of gene expression relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0010468 ! regulation of gene expression created_by: midori creation_date: 2012-08-01T16:33:19Z [Term] id: FYPO:0001334 name: regulation phenotype during vegetative growth def: "A cellular process phenotype that affects the regulation of a molecular function, biological process, or biological quality in the vegetative growth phase of the life cycle." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast regulation phenotype during vegetative growth" EXACT [PomBase:mah] synonym: "regulation phenotype during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000145 ! regulation phenotype is_a: FYPO:0001331 ! cellular process phenotype during vegetative growth intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0065007 ! biological regulation relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0065007 ! biological regulation created_by: midori creation_date: 2012-08-01T16:33:52Z [Term] id: FYPO:0001335 name: transcription regulation phenotype during vegetative growth def: "A gene expression phenotype that affects the regulation of DNA-dependent transcription in the vegetative growth phase of the life cycle." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast transcription regulation phenotype during vegetative growth" EXACT [PomBase:mah] synonym: "gene-specific transcription regulation phenotype during vegetative growth" RELATED [GO:0006355, PomBase:mah] synonym: "transcription regulation phenotype during mitotic cell cycle" RELATED [PomBase:mah] synonym: "transcriptional control phenotype during vegetative growth" BROAD [GO:0006355, PomBase:mah] is_a: FYPO:0000143 ! transcription regulation phenotype is_a: FYPO:0001333 ! gene expression regulation phenotype during vegetative growth intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006355 ! regulation of transcription, DNA-templated relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006355 ! regulation of transcription, DNA-templated created_by: midori creation_date: 2012-08-01T16:36:22Z [Term] id: FYPO:0001336 name: transport phenotype during vegetative growth def: "A cell process phenotype that affects a transport process in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "fission yeast transport phenotype during vegetative growth" EXACT [PomBase:mah] synonym: "transport phenotype during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000149 ! transport phenotype is_a: FYPO:0001337 ! localization phenotype during vegetative growth intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006810 ! transport relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006810 ! transport created_by: midori creation_date: 2012-08-01T16:55:04Z [Term] id: FYPO:0001337 name: localization phenotype during vegetative growth def: "A cell phenotype that affects the localization of a structure or substance in a cell in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "fission yeast localization phenotype during vegetative growth" EXACT [PomBase:mah] synonym: "localisation phenotype during vegetative growth" EXACT [PomBase:mah] synonym: "localization phenotype during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000138 ! localization phenotype is_a: FYPO:0001331 ! cellular process phenotype during vegetative growth intersection_of: FYPO:0000002 ! cell phenotype intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0051641 ! cellular localization relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0051641 ! cellular localization created_by: midori creation_date: 2012-08-01T16:55:18Z [Term] id: FYPO:0001338 name: abnormal nucleus localization during vegetative growth def: "A cellular process phenotype in which nucleus localization is abnormal in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "abnormal nuclear localization during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal nucleus localisation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal nucleus localization during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000517 ! abnormal nucleus localization is_a: FYPO:0001337 ! localization phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0051647 ! nucleus localization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0051647 ! nucleus localization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-01T17:07:26Z [Term] id: FYPO:0001339 name: abnormal cellular response to starvation during vegetative growth def: "A stress response phenotype in which the response to starvation for one or more nutrients is abnormal in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "abnormal cellular response to depletion during vegetative growth" EXACT [PomBase:vw] synonym: "abnormal cellular response to deprivation during vegetative growth" EXACT [PomBase:vw] synonym: "abnormal cellular response to starvation during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000713 ! abnormal cellular response to starvation is_a: FYPO:0001341 ! abnormal cellular response to stress during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0009267 ! cellular response to starvation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0009267 ! cellular response to starvation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-01T17:15:31Z [Term] id: FYPO:0001340 name: abnormal cellular response to oxidative stress during vegetative growth def: "A stress response phenotype in which a cellular response to oxidative stress is abnormal in the vegetative growth phase of the life cycle." [PomBase:mah] comment: Use this term if you have assayed the response to oxidative stress at the subcellular or molecular level. If you have assayed growth of cells exposed to oxidative stress in culture, use 'sensitive to oxidative stress' (FYPO:0000726). synonym: "abnormal cellular response to oxidative stress during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000180 ! abnormal cellular response to oxidative stress is_a: FYPO:0001341 ! abnormal cellular response to stress during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0034599 ! cellular response to oxidative stress intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0034599 ! cellular response to oxidative stress relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-01T17:18:23Z [Term] id: FYPO:0001341 name: abnormal cellular response to stress during vegetative growth def: "A cellular response phenotype in which a cellular response to stress is abnormal in the vegetative growth phase of the life cycle." [PomBase:mah] comment: Use this term if you have assayed the response to a stress at the subcellular or molecular level. If you have assayed growth of cells exposed to the stress in culture, use 'sensitive to stress during vegetative growth' (FYPO:0000304) or 'resistance to stress during vegetative growth' (FYPO:0000850) or a more specific term. synonym: "abnormal cellular response to stress during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000162 ! abnormal cellular response to stress is_a: FYPO:0001342 ! cellular response phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0033554 ! cellular response to stress intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0033554 ! cellular response to stress relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-01T17:19:19Z [Term] id: FYPO:0001342 name: cellular response phenotype during vegetative growth def: "A cellular process phenotype that affects a response to a stimulus in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "cellular response phenotype during mitotic cell cycle" RELATED [PomBase:mah] synonym: "fission yeast cellular response phenotype during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000298 ! cellular response phenotype is_a: FYPO:0001331 ! cellular process phenotype during vegetative growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0051716 ! cellular response to stimulus relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0051716 ! cellular response to stimulus created_by: midori creation_date: 2012-08-01T17:32:10Z [Term] id: FYPO:0001343 name: abnormal mitotic DNA replication def: "A cellular process phenotype in which DNA replication is abnormal in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "abnormal DNA replication during mitotic cell cycle" EXACT [PomBase:mah] synonym: "abnormal DNA replication during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal DNA-dependent DNA replication during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000217 ! abnormal DNA replication is_a: FYPO:0001346 ! DNA metabolism phenotype during vegetative growth is_a: FYPO:0001363 ! abnormal metabolic process during vegetative growth is_a: FYPO:0002737 ! abnormal mitotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1902969 ! mitotic DNA replication intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1902969 ! mitotic DNA replication relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-01T17:33:51Z [Term] id: FYPO:0001344 name: abnormal mitotic DNA replication initiation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the initiation of nuclear DNA replication is abnormal." [PomBase:mah] synonym: "abnormal DNA replication initiation during mitotic cell cycle" EXACT [PomBase:mah] synonym: "abnormal DNA replication initiation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000176 ! abnormal DNA replication initiation is_a: FYPO:0001343 ! abnormal mitotic DNA replication intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1902975 ! mitotic DNA replication initiation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1902975 ! mitotic DNA replication initiation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-01T17:34:25Z [Term] id: FYPO:0001345 name: abnormal DNA recombination during vegetative growth def: "A cellular process phenotype in which DNA recombination is abnormal in the vegetative growth phase of the life cycle. DNA recombination is a process that results in reassortment of genes, producing gene combinations different from those that were present in the parents." [GO:0006310, PomBase:mah] synonym: "abnormal DNA recombination during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal recombination during vegetative growth" EXACT [PomBase:vw] synonym: "recombination defects during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000063 ! abnormal DNA recombination is_a: FYPO:0001346 ! DNA metabolism phenotype during vegetative growth is_a: FYPO:0001363 ! abnormal metabolic process during vegetative growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006310 ! DNA recombination intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006310 ! DNA recombination relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-01T17:37:10Z [Term] id: FYPO:0001346 name: DNA metabolism phenotype during vegetative growth def: "A cellular process phenotype that affects any DNA metabolic process in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "DNA metabolism phenotype during mitotic cell cycle" RELATED [PomBase:mah] synonym: "fission yeast DNA metabolism phenotype during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000293 ! DNA metabolism phenotype is_a: FYPO:0001347 ! nucleic acid metabolism phenotype during vegetative growth intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006259 ! DNA metabolic process relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006259 ! DNA metabolic process created_by: midori creation_date: 2012-08-01T17:38:00Z [Term] id: FYPO:0001347 name: nucleic acid metabolism phenotype during vegetative growth def: "A cellular process phenotype that affects any nucleic acid metabolic process in the vegetative growth phase of the life cycle." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast nucleic acid metabolism phenotype during vegetative growth" EXACT [PomBase:mah] synonym: "nucleic acid metabolism phenotype during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000292 ! nucleic acid metabolism phenotype is_a: FYPO:0001348 ! cellular metabolism phenotype during vegetative growth intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0090304 ! nucleic acid metabolic process relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0090304 ! nucleic acid metabolic process created_by: midori creation_date: 2012-08-01T17:39:21Z [Term] id: FYPO:0001348 name: cellular metabolism phenotype during vegetative growth def: "A cellular process phenotype that affects metabolism in the cell in the vegetative growth phase of the life cycle." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "cellular metabolism phenotype during mitotic cell cycle" RELATED [PomBase:mah] synonym: "fission yeast cellular metabolism phenotype during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000140 ! cellular metabolism phenotype is_a: FYPO:0001331 ! cellular process phenotype during vegetative growth intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0044237 ! cellular metabolic process relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0044237 ! cellular metabolic process created_by: midori creation_date: 2012-08-01T17:40:24Z [Term] id: FYPO:0001350 name: abnormal microtubule cytoskeleton organization during vegetative growth def: "A phenotype that affects the organization of the microtubule cytoskeleton in the vegetative growth phase of the life cycle. Microtubule cytoskeleton organization is a cellular process that results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GO:0000226, PomBase:mah] comment: Consider annotating to 'abnormal microtubule cytoskeleton' (FYPO:0002399), but note that an abnormal microtubule cytoskeleton organization process may, but does not necessarily, result in a physically abnormal microtubule cytoskeleton. synonym: "abnormal microtubule cytoskeleton organisation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal microtubule cytoskeleton organization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal microtubule organisation during vegetative growth" RELATED [PomBase:mah] synonym: "abnormal microtubule organization during vegetative growth" RELATED [PomBase:mah] synonym: "microtubule cytoskeleton defects during vegetative growth" EXACT [PomBase:mah] synonym: "microtubule organization defects during vegetative growth" RELATED [PomBase:mah] is_a: FYPO:0000054 ! abnormal microtubule cytoskeleton organization is_a: FYPO:0001328 ! abnormal cytoskeleton organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000226 ! microtubule cytoskeleton organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000226 ! microtubule cytoskeleton organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-01T17:45:38Z [Term] id: FYPO:0001351 name: abnormal membrane organization during vegetative growth def: "A cellular process phenotype in which cellular membrane organization is abnormal in the vegetative growth phase of the life cycle. Cellular membrane organization results in the assembly, arrangement of constituent parts, or disassembly of a lipid bilayer membrane, such as the plasma membrane or an organelle membrane." [GO:0061024, PomBase:mah] synonym: "abnormal cellular membrane organization during vegetative growth" EXACT [GO:0061024, PomBase:mah] synonym: "abnormal membrane organisation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal membrane organization during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001013 ! abnormal membrane organization is_a: FYPO:0001353 ! abnormal cellular component organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0061024 ! membrane organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0061024 ! membrane organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-01T17:51:07Z [Term] id: FYPO:0001352 name: abnormal chromatin organization during vegetative growth def: "A cellular process phenotype in which any process of chromatin organization is abnormal in the vegetative growth phase of the life cycle. Chromatin organization results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GO:0006325, PomBase:mah] synonym: "abnormal chromatin organisation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal chromatin organization during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000642 ! abnormal chromatin organization is_a: FYPO:0001353 ! abnormal cellular component organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006325 ! chromatin organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006325 ! chromatin organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-01T17:56:15Z [Term] id: FYPO:0001353 name: abnormal cellular component organization during vegetative growth def: "A cellular process phenotype in which any process of cellular component organization at the cellular level is abnormal in the vegetative growth phase of the life cycle." [GO:0016043, PomBase:mah] synonym: "abnormal cellular component organisation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal cellular component organization at cellular level during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal cellular component organization during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000335 ! abnormal cellular component organization is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0016043 ! cellular component organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0016043 ! cellular component organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-01T18:11:39Z [Term] id: FYPO:0001354 name: abnormal cellular component assembly during vegetative growth def: "A cellular process phenotype in which any process of cellular component assembly at the cellular level is abnormal in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "abnormal cellular component assembly at cellular level during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal cellular component assembly during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000336 ! abnormal cellular component assembly is_a: FYPO:0001353 ! abnormal cellular component organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0022607 ! cellular component assembly intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0022607 ! cellular component assembly relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-01T18:14:28Z [Term] id: FYPO:0001355 name: decreased vegetative cell population growth def: "A cell population phenotype in which the growth of a population of cells is decreased relative to normal in the vegetative growth phase of the life cycle. Decreased growth may reflect a reduced growth rate (i.e. slower growth), growth that occurs to a lesser extent than normal, or both." [PomBase:mah] synonym: "aerobic vegetative growth defects" RELATED [PomBase:mah] synonym: "decreased vegetative aerobic cell population growth" NARROW [PomBase:mah] synonym: "reduced vegetative aerobic cell population growth" NARROW [PomBase:mah] synonym: "reduced vegetative growth" BROAD [PomBase:mah] synonym: "slow vegetative aerobic cell population growth" NARROW [PomBase:mah] is_a: FYPO:0000046 ! decreased cell population growth is_a: FYPO:0001356 ! abnormal vegetative cell population growth intersection_of: FYPO:0000046 ! decreased cell population growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase created_by: midori creation_date: 2012-08-01T18:16:46Z [Term] id: FYPO:0001356 name: abnormal vegetative cell population growth def: "A cellular process phenotype in which vegetative cell population growth is abnormal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. subset: qc_do_not_manually_annotate synonym: "vegetative growth defect" RELATED [PomBase:mah] is_a: FYPO:0000045 ! abnormal cell population growth is_a: FYPO:0001358 ! vegetative cell population growth phenotype is_a: PATO:0000001 ! quality intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-01T18:17:46Z [Term] id: FYPO:0001357 name: normal vegetative cell population growth def: "A cell population phenotype in which a population of cells grows normally in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "vegetative growth normal" BROAD [PomBase:mah] synonym: "vegetative population growth normal" EXACT [PomBase:mah] is_a: FYPO:0000047 ! normal cell population growth is_a: FYPO:0001358 ! vegetative cell population growth phenotype is_a: FYPO:0002060 ! viable vegetative cell population is_a: PATO:0000001 ! quality intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-08-01T18:20:01Z [Term] id: FYPO:0001358 name: vegetative cell population growth phenotype def: "A cell phenotype that affects the rate or extent of cell population growth in the vegetative growth phase of the life cycle." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "cell population growth phenotype during vegetative growth" EXACT [PomBase:mah] synonym: "fission yeast cell population growth phenotype during vegetative growth" EXACT [PomBase:mah] synonym: "vegetative cell population growth phenotype during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000139 ! cell population growth phenotype is_a: FYPO:0000300 ! biological process phenotype intersection_of: FYPO:0000139 ! cell population growth phenotype intersection_of: inheres_in_part_of GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0072690 ! single-celled organism vegetative growth phase created_by: midori creation_date: 2012-08-01T18:21:02Z [Term] id: FYPO:0001360 name: decreased amino acid import during vegetative growth def: "A cellular process phenotype in which the import of one or more amino acids into the cell occurs to a lower extent than normal in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "decreased amino acid import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased amino acid import into cell during vegetative growth" EXACT [PomBase:al] synonym: "decreased amino acid uptake during vegetative growth" EXACT [PomBase:mah] synonym: "reduced amino acid import during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001058 ! decreased amino acid import is_a: FYPO:0001361 ! abnormal amino acid import during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902837 ! amino acid import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902837 ! amino acid import into cell created_by: midori creation_date: 2012-08-02T14:51:40Z [Term] id: FYPO:0001361 name: abnormal amino acid import during vegetative growth def: "A cellular process phenotype in which the import of one or more amino acids into the cell is abnormal in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "abnormal amino acid import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal amino acid import into cell during vegetative growth" EXACT [PomBase:al] synonym: "abnormal amino acid uptake during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001057 ! abnormal amino acid import is_a: FYPO:0001336 ! transport phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1902837 ! amino acid import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1902837 ! amino acid import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-02T14:52:32Z [Term] id: FYPO:0001362 name: abnormal cellular process during vegetative growth def: "A phenotype in which a specific cellular process is abnormal in the vegetative growth phase of the life cycle." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "abnormal cellular process during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000628 ! abnormal cellular process is_a: FYPO:0001331 ! cellular process phenotype during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0044763 ! single-organism cellular process intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0044763 ! single-organism cellular process relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-02T14:55:51Z [Term] id: FYPO:0001363 name: abnormal metabolic process during vegetative growth def: "A cellular process phenotype in which a cellular metabolic process is abnormal in the vegetative growth phase of the life cycle. A metabolic process is any set of chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances." [GO:0044237, PomBase:mah] synonym: "abnormal cellular metabolic process during vegetative growth" EXACT [GO:0044237, PomBase:mah] synonym: "abnormal metabolic process during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal metabolism during vegetative growth" EXACT [GO:0044237, PomBase:mah] is_a: FYPO:0000860 ! abnormal metabolic process is_a: FYPO:0001348 ! cellular metabolism phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0044237 ! cellular metabolic process intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0044237 ! cellular metabolic process relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-02T18:07:32Z [Term] id: FYPO:0001364 name: abnormal actomyosin contractile ring contraction def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which actomyosin contractile ring contraction is abnormal. Contractile ring contraction is the part of cytokinesis in which the actomyosin contractile ring constricts." [GO:1902404, PomBase:mah] synonym: "abnormal actomyosin contractile ring constriction" EXACT [PomBase:vw] synonym: "abnormal actomyosin contractile ring contraction during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal contractile ring contraction" EXACT [PomBase:vw] synonym: "abnormal cytokinetic contractile ring contraction" EXACT [PomBase:vw] synonym: "abnormal mitotic actomyosin contractile ring contraction" EXACT [GO:1902404, PomBase:mah] synonym: "abnormal mitotic contractile ring contraction" EXACT [PomBase:vw] is_a: FYPO:0000032 ! abnormal cytokinesis intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1902404 ! mitotic actomyosin contractile ring contraction intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1902404 ! mitotic actomyosin contractile ring contraction relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-07T12:39:39Z [Term] id: FYPO:0001365 name: decreased rate of actomyosin contractile ring contraction def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the rate, or speed, of actomyosin contractile ring contraction is decreased. Contractile ring contraction is the part of cytokinesis in which the actomyosin contractile ring constricts." [GO:1902404, PomBase:mah] synonym: "decreased rate of actomyosin contractile ring constriction" EXACT [PomBase:mah] synonym: "decreased rate of actomyosin contractile ring contraction during vegetative growth" EXACT [PomBase:mah] synonym: "decreased rate of contractile ring contraction" EXACT [PomBase:vw] synonym: "decreased rate of cytokinetic contractile ring contraction" EXACT [PomBase:vw] synonym: "decreased rate of mitotic actomyosin contractile ring contraction" EXACT [GO:1902404, PomBase:mah] synonym: "decreased rate of mitotic contractile ring contraction" EXACT [PomBase:vw] synonym: "reduced rate of actomyosin contractile ring contraction" EXACT [PomBase:mah] is_a: FYPO:0000419 ! decreased rate of cytokinesis is_a: FYPO:0001364 ! abnormal actomyosin contractile ring contraction intersection_of: PATO:0000911 ! decreased rate intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902404 ! mitotic actomyosin contractile ring contraction relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902404 ! mitotic actomyosin contractile ring contraction created_by: midori creation_date: 2012-08-07T12:41:50Z [Term] id: FYPO:0001366 name: normal actin cytoskeleton organization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which actin cytoskeleton organization is normal (i.e. indistinguishable from wild type). Actin cytoskeleton organization is the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GO:0030036, PomBase:mah] synonym: "normal actin cytoskeleton organisation" EXACT [PomBase:mah] synonym: "normal actin cytoskeleton organization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal actin cytoskeleton organization during vegetative growth" EXACT [PomBase:mah] synonym: "normal actin filament organization" RELATED [PomBase:mah] is_a: FYPO:0001319 ! normal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0030036 ! actin cytoskeleton organization intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0030036 ! actin cytoskeleton organization relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-08-07T12:51:48Z [Term] id: FYPO:0001367 name: normal cytokinesis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which cytokinesis is normal (i.e. indistinguishable from wild type). Cytokinesis is part of the cell cycle and results in the division of the cytoplasm of a cell and its separation into two daughter cells." [GO:0000281, PomBase:mah] synonym: "normal cell cycle cytokinesis" EXACT [PomBase:mah] synonym: "normal cytokinesis during vegetative growth" EXACT [PomBase:mah] synonym: "normal mitotic cytokinesis" EXACT [GO:0000281, PomBase:mah] is_a: FYPO:0002741 ! normal mitotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000281 ! mitotic cytokinesis intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000281 ! mitotic cytokinesis relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-08-07T12:54:44Z [Term] id: FYPO:0001368 name: normal actomyosin contractile ring assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which contractile ring assembly is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal actomyosin contractile ring assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal actomyosin contractile ring assembly during vegetative growth" EXACT [PomBase:mah] synonym: "normal actomyosin contractile ring formation" RELATED [GO:0000915, PomBase:vw] synonym: "normal contractile ring assembly" EXACT [PomBase:mah] synonym: "normal cytokinesis, actomyosin contractile ring assembly" EXACT [PomBase:mah] synonym: "normal cytokinetic contractile ring assembly" EXACT [PomBase:vw] synonym: "normal cytokinetic ring assembly" RELATED [PomBase:vw] synonym: "normal cytokinetic ring formation" RELATED [PomBase:vw] synonym: "normal mitotic contractile ring assembly" EXACT [PomBase:vw] is_a: FYPO:0001366 ! normal actin cytoskeleton organization is_a: FYPO:0001367 ! normal cytokinesis is_a: FYPO:0001845 ! normal kinetochore organization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000915 ! actomyosin contractile ring assembly intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000915 ! actomyosin contractile ring assembly relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-08-07T12:54:57Z [Term] id: FYPO:0001369 name: mislocalized actomyosin contractile ring def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell forms an actomyosin contractile ring in an abnormal location. The normal location is at the midpoint of, and perpendicular to, the long axis of the cell." [PomBase:mah] comment: Note that the location of the contractile ring is determined by the location of the cell division site, so an abnormality in cell division site determination can be inferred from this phenotype. Consider also annotating to 'mislocalized septum' (FYPO:0000339) because if the contractile ring forms in an abnormal location, the septum will also do so. synonym: "contractile ring displaced from cell centre" EXACT [PomBase:vw] synonym: "mislocalised actomyosin contractile ring" EXACT [PomBase:mah] synonym: "mislocalized actomyosin contractile ring during mitotic cell cycle" RELATED [PomBase:mah] synonym: "mislocalized actomyosin contractile ring during vegetative growth" EXACT [PomBase:mah] synonym: "mislocalized cytokinetic contractile ring" EXACT [PomBase:vw] synonym: "mislocalized mitotic contractile ring" EXACT [PomBase:vw] is_a: FYPO:0004736 ! abnormal actomyosin contractile ring is_a: PATO:0000628 ! mislocalised intersection_of: PATO:0000628 ! mislocalised intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005826 ! actomyosin contractile ring relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005826 ! actomyosin contractile ring relationship: output_of FYPO:0000033 ! abnormal actomyosin contractile ring localization created_by: midori creation_date: 2012-08-07T13:31:19Z [Term] id: FYPO:0001370 name: abnormal protein localization def: "A cell phenotype in which the localization of a protein in a cell is abnormal. A protein may be observed in a place where it is not normally found, absent from a place where it is normally found, or both." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "abnormal cellular protein localisation" EXACT [PomBase:mah] synonym: "abnormal cellular protein localization" EXACT [PomBase:mah] synonym: "abnormal protein localisation" EXACT [PomBase:mah] synonym: "protein/peptide distribution: abnormal" RELATED [SGD:phenotype_annotation] is_a: FYPO:0000628 ! abnormal cellular process is_a: FYPO:0002333 ! protein localization phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0034613 ! cellular protein localization intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0034613 ! cellular protein localization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-07T13:40:05Z [Term] id: FYPO:0001371 name: abolished protein localization to medial cortex def: "A cell phenotype in which the localization of a protein to the medial cortex is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "protein localisation to medial cortex abolished" EXACT [GO:0071574, PomBase:mah] synonym: "protein localization to medial cortex abolished" EXACT [PomBase:mah] synonym: "protein localization to medial ring abolished" EXACT [GO:0031097, GO:0071574] is_a: FYPO:0001373 ! abnormal protein localization to medial cortex is_a: FYPO:0001375 ! protein localization abolished intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0071574 ! protein localization to medial cortex relationship: towards GO:0071574 ! protein localization to medial cortex created_by: midori creation_date: 2012-08-07T13:55:44Z [Term] id: FYPO:0001372 name: abnormal protein localization to medial cortex in spores def: "A cell phenotype in which the localization of a protein to the medial cortex of a spore is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found at the medial cortex and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to medial cortex in spores" EXACT [GO:0071574, PomBase:mah] synonym: "abnormal protein localization to medial ring in spores" EXACT [GO:0031097, GO:0071574] is_a: FYPO:0001373 ! abnormal protein localization to medial cortex intersection_of: FYPO:0001373 ! abnormal protein localization to medial cortex intersection_of: inheres_in CL:0000596 ! sexual spore relationship: inheres_in CL:0000596 ! sexual spore created_by: midori creation_date: 2012-08-07T13:49:04Z [Term] id: FYPO:0001373 name: abnormal protein localization to medial cortex def: "A cell phenotype in which the localization of a protein to the medial cortex is abnormal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. Encompasses both presence of proteins not normally found at the medial cortex and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. subset: qc_do_not_manually_annotate synonym: "abnormal protein localisation to medial cortex" EXACT [GO:0071574, PomBase:mah] synonym: "abnormal protein localization to medial ring" EXACT [GO:0031097, GO:0071574] is_a: FYPO:0001370 ! abnormal protein localization intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0071574 ! protein localization to medial cortex intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0071574 ! protein localization to medial cortex relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-07T13:49:11Z [Term] id: FYPO:0001374 name: abolished protein localization to medial cortex in spores def: "A cell phenotype in which the localization of a protein to the medial cortex of a spore is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "protein localisation to medial cortex abolished in spores" EXACT [GO:0071574, PomBase:mah] synonym: "protein localization to medial cortex abolished in spores" EXACT [PomBase:mah] synonym: "protein localization to medial ring abolished in spores" EXACT [GO:0031097, GO:0071574] is_a: FYPO:0001371 ! abolished protein localization to medial cortex is_a: FYPO:0001372 ! abnormal protein localization to medial cortex in spores intersection_of: PATO:0001558 ! lacking processual parts intersection_of: inheres_in CL:0000596 ! sexual spore intersection_of: towards GO:0071574 ! protein localization to medial cortex relationship: inheres_in CL:0000596 ! sexual spore relationship: towards GO:0071574 ! protein localization to medial cortex created_by: midori creation_date: 2012-08-07T13:56:10Z [Term] id: FYPO:0001375 name: protein localization abolished def: "A cell phenotype in which a protein does not localize to, and is therefore absent from, a place where it is normally found." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. If this term is used, we recommend noting which protein(s) were used in the assay. subset: qc_do_not_manually_annotate synonym: "abolished protein localization" EXACT [PomBase:mah] synonym: "protein absent from specific location in cell" RELATED [PomBase:mah] synonym: "protein localisation abolished" EXACT [PomBase:mah] is_a: FYPO:0001370 ! abnormal protein localization is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0034613 ! cellular protein localization relationship: towards GO:0034613 ! cellular protein localization created_by: midori creation_date: 2012-08-07T13:56:37Z [Term] id: FYPO:0001376 name: normal cellular calcium level during cellular response to salt stress def: "A cell phenotype in which the amount of calcium ion measured in a cell during a cellular response to salt stress is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular calcium accumulation during cellular response to salt stress" RELATED [PomBase:mah] synonym: "normal cellular calcium ion level during cellular response to salt stress" EXACT [PomBase:mah] is_a: FYPO:0001199 ! normal cellular calcium level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0071472 ! cellular response to salt stress intersection_of: inheres_in CL:0000000 ! cell intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:29108 ! calcium(2+) relationship: exists_during GO:0071472 ! cellular response to salt stress relationship: inheres_in CL:0000000 ! cell relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:29108 ! calcium(2+) created_by: midori creation_date: 2012-08-07T14:56:53Z [Term] id: FYPO:0001377 name: decreased cellular calcium level during cellular response to salt stress def: "A cell phenotype in which the amount of calcium ion measured in a cell during a cellular response to salt stress is lower than normal." [PomBase:mah] synonym: "decreased calcium accumulation during cellular response to salt stress" RELATED [PomBase:al] synonym: "decreased cellular calcium ion level during cellular response to salt stress" EXACT [PomBase:mah] synonym: "decreased cellular calcium level during cellular response to salt stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular calcium level during cellular response to salt stress during vegetative growth" EXACT [PomBase:mah] synonym: "reduced cellular calcium level during cellular response to salt stress" EXACT [PomBase:mah] is_a: FYPO:0001197 ! decreased cellular calcium level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0071472 ! cellular response to salt stress intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:29108 ! calcium(2+) relationship: exists_during GO:0071472 ! cellular response to salt stress relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:29108 ! calcium(2+) created_by: midori creation_date: 2012-08-07T14:58:22Z [Term] id: FYPO:0001378 name: increased cellular calcium level during cellular response to salt stress def: "A cell phenotype in which the amount of calcium ion measured in a cell during a cellular response to salt stress is higher than normal." [PomBase:mah] synonym: "increased calcium accumulation during cellular response to salt stress" RELATED [PomBase:mah] synonym: "increased cellular calcium ion level during cellular response to salt stress" EXACT [PomBase:mah] synonym: "increased cellular calcium level during cellular response to salt stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular calcium level during cellular response to salt stress during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001198 ! increased cellular calcium level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0071472 ! cellular response to salt stress intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:29108 ! calcium(2+) relationship: exists_during GO:0071472 ! cellular response to salt stress relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:29108 ! calcium(2+) created_by: midori creation_date: 2012-08-07T14:58:54Z [Term] id: FYPO:0001379 name: resistance to tacrolimus def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of tacrolimus than normal." [PomBase:mah] synonym: "resistance to FK506" EXACT [CHEBI:61057, PomBase:mah] synonym: "resistance to tacrolimus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to tacrolimus during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to tacrolimus" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:61057 ! tacrolimus hydrate relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:61057 ! tacrolimus hydrate created_by: midori creation_date: 2012-08-07T15:05:20Z [Term] id: FYPO:0001380 name: normal nuclear morphology during vegetative growth def: "A physical cellular phenotype in which the size, shape, or structure of the nucleus is normal (i.e. indistinguishable from wild type) in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "normal nuclear morphology during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001313 ! normal subcellular component during vegetative growth is_a: FYPO:0001673 ! normal nuclear morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005634 ! nucleus intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005634 ! nucleus relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-08-07T15:06:55Z [Term] id: FYPO:0001381 name: abnormal protein kinase activity def: "A molecular function phenotype in which the observed rate of a protein kinase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004672 ! protein kinase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004672 ! protein kinase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-09T16:05:03Z [Term] id: FYPO:0001382 name: decreased protein kinase activity def: "A molecular function phenotype in which the observed rate of a protein kinase activity is decreased." [PomBase:mah] synonym: "reduced protein kinase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0001381 ! abnormal protein kinase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004672 ! protein kinase activity relationship: inheres_in GO:0004672 ! protein kinase activity created_by: midori creation_date: 2012-08-09T16:06:18Z [Term] id: FYPO:0001383 name: normal DNA content def: "A cell phenotype in which the amount of DNA measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0001076 ! normal level of substance in cell intersection_of: PATO:0001159 ! concentrated intersection_of: inheres_in CL:0000000 ! cell intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:16991 ! deoxyribonucleic acid relationship: inheres_in CL:0000000 ! cell relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:16991 ! deoxyribonucleic acid created_by: midori creation_date: 2012-08-09T16:33:17Z [Term] id: FYPO:0001384 name: abolished protein kinase activity def: "A molecular function phenotype in which a protein kinase activity is absent." [PomBase:mah] synonym: "protein kinase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0001381 ! abnormal protein kinase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0004672 ! protein kinase activity relationship: towards GO:0004672 ! protein kinase activity created_by: midori creation_date: 2012-08-10T13:54:04Z [Term] id: FYPO:0001385 name: inviable after spore germination, without cell division, cell cycle arrest with replicated DNA def: "A phenotype in which a spore germinates to produce a cell that enters the cell cycle but then undergoes cell cycle arrest with replicated DNA, and eventually dies." [PMID:9705504, PomBase:mah] synonym: "essential; germinating spore, without cell division, cell cycle arrest with replicated DNA" RELATED [PomBase:mah] synonym: "inviable following spore germination, without cell division, cell cycle arrest with replicated DNA" EXACT [PomBase:mah] synonym: "inviable germinated spore, without cell division, cell cycle arrest with replicated DNA" EXACT [PomBase:mah] is_a: FYPO:0001924 ! inviable after spore germination, without cell division, cell cycle arrest intersection_of: FYPO:0000316 ! inviable after spore germination intersection_of: has_part FYPO:0000444 ! abnormal mitotic cell cycle arrest with replicated DNA relationship: has_part FYPO:0000444 ! abnormal mitotic cell cycle arrest with replicated DNA created_by: midori creation_date: 2012-08-10T14:06:51Z [Term] id: FYPO:0001386 name: increased haploidization alt_id: FYPO:0001781 def: "A cell phenotype in which non-sporulating diploid cells become haploid, without undergoing meiosis, at a higher frequency than normal." [PMID:9914167, PomBase:al, PomBase:mah] comment: Diploid cells may become haploid by chromosome loss, or by undergoing premature mitosis. Chromosome loss may also cause aneuploidy or cell death. synonym: "unstable diploid" EXACT [PomBase:mah] is_a: FYPO:0001320 ! vegetative cell phenotype is_a: FYPO:0003037 ! abnormal cell phenotype created_by: midori creation_date: 2012-08-10T14:51:16Z [Term] id: FYPO:0001387 name: loss of viability at high temperature def: "A cell population phenotype in which a smaller than normal proportion of the population remains viable when are grown at a temperature higher than standard." [PomBase:mah] comment: For S. pombe, high temperature usually means above 32 degrees C. Use this term to annotate experiments in which a culture is grown at high temperature, and then the number of cells viable enough to form a colony upon return to standard or low temperature is measured and compared to wild type. synonym: "decreased viability at high temperature" EXACT [PomBase:mah] synonym: "loss of cell population viability at high temperature" EXACT [PomBase:mah] synonym: "loss of viability at restrictive temperature" RELATED [PomBase:mah] synonym: "reduced viability at high temperature" EXACT [PomBase:mah] is_a: FYPO:0001985 ! abnormal phenotype is_a: FYPO:0002057 ! cell population viability created_by: midori creation_date: 2012-08-10T14:55:36Z [Term] id: FYPO:0001388 name: decreased protein level in germinating spore def: "A cell phenotype in which the amount of protein measured in a cell is lower than normal during or just after spore germination. Total protein or a specific protein may be affected." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "reduced protein level in germinating spore" EXACT [PomBase:mah] is_a: FYPO:0000835 ! decreased protein level intersection_of: PATO:0001163 ! decreased concentration intersection_of: inheres_in CL:0000596 ! sexual spore intersection_of: towards CHEBI:36080 ! protein relationship: inheres_in CL:0000596 ! sexual spore relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2012-08-10T16:32:24Z [Term] id: FYPO:0001389 name: normal nucleus localization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which nucleus localization is normal." [PomBase:mah] synonym: "normal nuclear localization" EXACT [PomBase:mah] synonym: "normal nuclear position" EXACT [PomBase:mah] synonym: "normal nucleus localisation" EXACT [PomBase:mah] synonym: "normal nucleus localization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal nucleus localization during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001319 ! normal cellular process during vegetative growth is_a: FYPO:0001337 ! localization phenotype during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0051647 ! nucleus localization intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0051647 ! nucleus localization relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-08-15T11:46:28Z [Term] id: FYPO:0001390 name: misoriented septum during vegetative growth def: "A septation phenotype observed in the vegetative growth phase of the life cycle in which a cell forms a septum that is not perpendicular to the long axis of the cell." [PomBase:mah] comment: Consider also annotating to 'angled actomyosin contractile ring' (FYPO:0002027) because if the contractile ring forms at an abnormal angle, the septum will also do so. synonym: "abnormal septum orientation during vegetative growth" EXACT [PomBase:mah] synonym: "misoriented septum during mitotic cell cycle" RELATED [PomBase:mah] synonym: "tilted septum during vegetative growth" EXACT [PomBase:al] is_a: FYPO:0002455 ! abnormal septum during vegetative growth is_a: PATO:0000133 ! orientation intersection_of: PATO:0000133 ! orientation intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000935 ! barrier septum intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000935 ! barrier septum relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-15T13:03:09Z [Term] id: FYPO:0001391 name: mislocalized septum, near new end def: "A septation phenotype observed in the vegetative growth phase of the life cycle in which a cell forms a septum closer to the new end of the cell (when the new end is not yet growing), instead of at the midpoint of the long axis." [PomBase:mah] synonym: "abnormal septum location, near new end" EXACT [PomBase:mah] synonym: "abnormal septum location, near non-growing end" NARROW [PomBase:mah] synonym: "abnormal septum position, near new end" EXACT [PomBase:mah] synonym: "abnormal septum position, near non-growing end" NARROW [PomBase:mah] synonym: "asymmetric septum, near new end" EXACT [PomBase:mah] synonym: "asymmetric septum, near non-growing end" NARROW [PomBase:mah] synonym: "asymmetrically located septum, near new end" EXACT [PomBase:mah] synonym: "asymmetrically located septum, near non-growing end" NARROW [PomBase:mah] synonym: "mislocalised septum, near new end" EXACT [PomBase:mah] synonym: "mislocalised septum, near non-growing end" NARROW [PomBase:mah] synonym: "mislocalized septum, near new end during mitotic cell cycle" RELATED [PomBase:mah] synonym: "mislocalized septum, near new end, during vegetative growth" EXACT [PomBase:mah] synonym: "mislocalized septum, near non-growing end" NARROW [PomBase:mah] synonym: "mislocalized septum, near non-growing end, during vegetative growth" NARROW [PomBase:mah] synonym: "misplaced septum, near new end" EXACT [PomBase:vw] is_a: FYPO:0000339 ! mislocalized septum during vegetative growth is_a: FYPO:0001225 ! monoseptate created_by: midori creation_date: 2012-08-15T13:08:14Z [Term] id: FYPO:0001392 name: abnormal regulation of cell growth def: "A regulation phenotype in which regulation of vegetative cell growth is abnormal." [PomBase:mah] synonym: "abnormal regulation of vegetative cell growth" EXACT [PomBase:mah] is_a: FYPO:0001334 ! regulation phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0001558 ! regulation of cell growth intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0001558 ! regulation of cell growth relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-15T13:20:37Z [Term] id: FYPO:0001393 name: abnormal activation of monopolar cell growth def: "A regulation phenotype observed in the vegetative growth phase of the life cycle in which the activation of monopolar cell growth, i.e. the initiation of growth at the old end of a cell following cell division, is abnormal." [PomBase:mah] synonym: "abnormal regulation of monopolar vegetative cell growth" RELATED [PomBase:mah] is_a: FYPO:0001392 ! abnormal regulation of cell growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0051522 ! activation of monopolar cell growth intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0051522 ! activation of monopolar cell growth relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-15T13:21:29Z [Term] id: FYPO:0001394 name: activation of monopolar cell growth at either end def: "A regulation phenotype observed in the vegetative growth phase of the life cycle in which the activation of monopolar cell growth may occur at either the new or old end of the cell, instead of exclusively at the old end, following cell division. A population of cells with this phenotype has a 1:1 mix of cells initiating growth at the new end and cells initiating growth at the old end." [PomBase:mah] synonym: "abnormal initiation of growth from either old or new end following cell division" EXACT [PomBase:al] synonym: "activation of monopolar vegetative cell growth at either end" EXACT [PomBase:mah] is_a: FYPO:0001393 ! abnormal activation of monopolar cell growth created_by: midori creation_date: 2012-08-15T13:23:28Z [Term] id: FYPO:0001395 name: normal activation of monopolar cell growth def: "A regulation phenotype observed in the vegetative growth phase of the life cycle in which the activation of monopolar cell growth, i.e. the initiation of growth at the old end of a cell following cell division, is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal activation of monopolar vegetative cell growth" EXACT [PomBase:mah] synonym: "normal initiation of growth from old end following cell division" EXACT [PomBase:al] is_a: FYPO:0001319 ! normal cellular process during vegetative growth is_a: FYPO:0001334 ! regulation phenotype during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051522 ! activation of monopolar cell growth intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051522 ! activation of monopolar cell growth relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-08-15T13:35:02Z [Term] id: FYPO:0001396 name: normal activation of bipolar cell growth def: "A regulation phenotype observed in the vegetative growth phase of the life cycle in which activation of bipolar cell growth is normal; results in normal new end take-off." [PomBase:mah] synonym: "normal activation of bipolar vegetative cell growth" EXACT [PomBase:mah] synonym: "normal NETO" EXACT [PomBase:mah] synonym: "normal new end take off" EXACT [PomBase:mah] is_a: FYPO:0001334 ! regulation phenotype during vegetative growth is_a: PATO:0000001 ! quality intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051519 ! activation of bipolar cell growth intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051519 ! activation of bipolar cell growth relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-08-15T13:48:18Z [Term] id: FYPO:0001397 name: monopolar actin cortical patch localization to old end def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which actin cortical patches are localized to only the old end of a cell following cell division." [PomBase:mah] synonym: "monopolar actin cortical patch localisation to old end" EXACT [PomBase:mah] synonym: "monopolar actin cortical patch localization to old end during mitotic cell cycle" RELATED [PomBase:mah] synonym: "monopolar actin cortical patch localization to old end during vegetative growth" EXACT [PomBase:mah] synonym: "monopolar actin cortical patch location at old end" RELATED [PomBase:mah] is_a: FYPO:0001019 ! monopolar actin cortical patch localization created_by: midori creation_date: 2012-08-15T14:00:14Z [Term] id: FYPO:0001398 name: monopolar actin cortical patch localization to either end def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which actin cortical patches are localized to only one end of a cell following cell division; patches may localize to either the old or the new end. A population of cells with this phenotype has a 1:1 mix of cells with actin patches at the old end and cells with patches at the new end." [PomBase:mah] synonym: "monopolar actin cortical patch localisation to either end" EXACT [PomBase:mah] synonym: "monopolar actin cortical patch localization to either end during mitotic cell cycle" RELATED [PomBase:mah] synonym: "monopolar actin cortical patch localization to either end during vegetative growth" EXACT [PomBase:mah] synonym: "monopolar actin cortical patch location at either end" RELATED [PomBase:mah] is_a: FYPO:0001019 ! monopolar actin cortical patch localization created_by: midori creation_date: 2012-08-15T14:06:42Z [Term] id: FYPO:0001399 name: normal mitotic spindle def: "A physical cellular phenotype in which the mitotic spindle is normal (i.e. indistinguishable from wild type) with respect to structure, composition, location, and orientation." [PomBase:mah] synonym: "normal mitotic spindle during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001313 ! normal subcellular component during vegetative growth is_a: FYPO:0004568 ! normal spindle intersection_of: PATO:0000001 ! quality intersection_of: exists_during GO:0007067 ! mitotic nuclear division intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072686 ! mitotic spindle intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0007067 ! mitotic nuclear division relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072686 ! mitotic spindle relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-08-15T14:29:30Z [Term] id: FYPO:0001400 name: normal interphase cytoplasmic microtubules def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the morphology of cytoplasmic microtubules is normal (i.e. indistinguishable from wild type) during interphase of the mitotic cell cycle." [PomBase:mah] synonym: "normal cytoplasmic microtubules during interphase" EXACT [PomBase:mah] synonym: "normal interphase cytoplasmic microtubules during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal interphase cytoplasmic microtubules during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001976 ! normal cytoplasmic microtubules is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0007067 ! mitotic nuclear division intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005881 ! cytoplasmic microtubule intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0007067 ! mitotic nuclear division relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005881 ! cytoplasmic microtubule relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-08-15T14:40:33Z [Term] id: FYPO:0001401 name: abnormal protein localization to cell division site def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the site of cell division is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found at the cell division site and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to cell division site" EXACT [PomBase:mah] synonym: "abnormal protein localization to cell division site during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein localization to cell division site during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000443 ! abnormal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0072741 ! protein localization to cell division site intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0072741 ! protein localization to cell division site relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-15T15:14:14Z [Term] id: FYPO:0001402 name: normal protein localization to cell cortex def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the cell cortex is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to cell cortex" EXACT [PomBase:mah] synonym: "normal protein localization to cell cortex during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to cell cortex during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000644 ! normal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072697 ! protein localization to cell cortex intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072697 ! protein localization to cell cortex relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-08-15T15:15:59Z [Term] id: FYPO:0001403 name: increased cell-substrate adhesion def: "A cell adhesion phenotype observed in the vegetative growth phase of the life cycle in which cells adhere to a substrate more strongly or to a greater extent than normal." [PomBase:mah] synonym: "increased cell-substrate adhesion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cell-substrate adhesion during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000009 ! abnormal cell adhesion during vegetative growth is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0031589 ! cell-substrate adhesion relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0031589 ! cell-substrate adhesion created_by: midori creation_date: 2012-08-15T15:36:37Z [Term] id: FYPO:0001404 name: irregular colony morphology def: "A colony morphology phenotype in which the outline of a colony growing on a solid surface is not symmetrical." [PomBase:mah, PomBase:mp] synonym: "wavy-edged colony" RELATED [PomBase:vw] is_a: FYPO:0000150 ! abnormal colony morphology created_by: midori creation_date: 2012-08-15T15:38:42Z [Term] id: FYPO:0001405 name: glossy colony morphology def: "A colony morphology phenotype in which a colony growing on a solid surface has an abnormally glossy surface." [PomBase:mah, PomBase:mp] synonym: "smooth colony morphology" RELATED [PomBase:vw] is_a: FYPO:0000150 ! abnormal colony morphology created_by: midori creation_date: 2012-08-15T15:40:06Z [Term] id: FYPO:0001406 name: increased septum thickness def: "A septation phenotype observed in the vegetative growth phase of the life cycle in which a cell forms a septum that is thicker than normal." [PomBase:mah] synonym: "increased septum thickness during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased septum thickness during vegetative growth" EXACT [PomBase:mah] synonym: "thick septum" EXACT [PomBase:mah] is_a: FYPO:0002023 ! abnormal septum morphology during vegetative growth is_a: PATO:0000591 ! increased thickness intersection_of: PATO:0000591 ! increased thickness intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000935 ! barrier septum relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000935 ! barrier septum created_by: midori creation_date: 2012-08-15T15:43:42Z [Term] id: FYPO:0001407 name: decreased cell population growth on glucose carbon source alt_id: FYPO:0001161 alt_id: FYPO:0001163 def: "A vegetative cell population growth phenotype in which cell growth is decreased relative to normal in a medium containing glucose as the carbon source." [PomBase:mah] comment: Note that this term encompasses growth under aerobic or semi-anaerobic conditions, whereas most cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "decreased aerobic cell population growth on glucose carbon source" NARROW [PomBase:mah] synonym: "decreased growth on glucose carbon source" BROAD [PomBase:mah] synonym: "decreased hypoxic cell population growth on glucose carbon source" NARROW [PomBase:mah] synonym: "decreased vegetative cell growth on glucose carbon source" EXACT [PomBase:mah] synonym: "reduced cell growth on glucose carbon source" EXACT [PomBase:mah] synonym: "slow cell growth on glucose carbon source" NARROW [PomBase:mah] is_a: FYPO:0001355 ! decreased vegetative cell population growth intersection_of: FYPO:0000046 ! decreased cell population growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:17634 ! D-glucose relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:17634 ! D-glucose created_by: midori creation_date: 2012-08-16T15:53:30Z [Term] id: FYPO:0001408 name: sensitive to heat shock def: "A cell phenotype in which cells show increased sensitivity to heat shock. Heat shock is a form of heat stress in which cells are briefly exposed to a very high temperature." [PomBase:mah] synonym: "hypersensitive to heat shock" EXACT [PomBase:mah] is_a: FYPO:0000082 ! decreased cell population growth at high temperature created_by: midori creation_date: 2012-08-16T16:02:56Z [Term] id: FYPO:0001409 name: normal growth on glycerol carbon source def: "A vegetative cell population growth phenotype in which cells grow normally in a medium containing glycerol as the carbon source." [PomBase:mah] synonym: "normal cell population growth on glycerol carbon source" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal vegetative cell population growth on glycerol carbon source" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0000047 ! normal cell population growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:17754 ! glycerol relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:17754 ! glycerol created_by: midori creation_date: 2012-08-16T16:19:09Z [Term] id: FYPO:0001410 name: normal cellular sulfide level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of sulfide (S2-, also called acid labile sulfide) measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular acid labile sulfide level" EXACT [PomBase:al] synonym: "normal cellular sulfide accumulation" RELATED [PomBase:mah] synonym: "normal cellular sulfide ion level" EXACT [PomBase:mah] synonym: "normal cellular sulfide level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular sulfide level during vegetative growth" EXACT [PomBase:mah] synonym: "normal cellular sulphide level" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:15138 ! sulfide(2-) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:15138 ! sulfide(2-) created_by: midori creation_date: 2012-08-16T16:41:11Z [Term] id: FYPO:0001411 name: altered cellular sulfide level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of sulfide (S2-, also called acid labile sulfide) measured in a cell differs from normal." [PomBase:mah] synonym: "abnormal cellular sulfide accumulation" RELATED [PomBase:mah] synonym: "abnormal cellular sulfide level" EXACT [PomBase:mah] synonym: "altered cellular acid labile sulfide level" EXACT [PomBase:al] synonym: "altered cellular sulfide ion level" EXACT [PomBase:mah] synonym: "altered cellular sulfide level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "altered cellular sulfide level during vegetative growth" EXACT [PomBase:mah] synonym: "altered cellular sulphide level" EXACT [PomBase:mah] is_a: FYPO:0001323 ! altered level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:15138 ! sulfide(2-) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:15138 ! sulfide(2-) created_by: midori creation_date: 2012-08-16T16:43:19Z [Term] id: FYPO:0001412 name: decreased cellular sulfide level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of sulfide (S2-, also called acid labile sulfide) measured in a cell is lower than normal." [PomBase:mah] synonym: "decreased cellular acid labile sulfide level" EXACT [PomBase:al] synonym: "decreased cellular sulfide accumulation" RELATED [PomBase:mah] synonym: "decreased cellular sulfide ion level" EXACT [PomBase:mah] synonym: "decreased cellular sulfide level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular sulfide level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased cellular sulphide level" EXACT [PomBase:mah] synonym: "reduced cellular sulfide level" EXACT [PomBase:mah] is_a: FYPO:0001329 ! decreased level of substance in cell during vegetative growth is_a: FYPO:0001411 ! altered cellular sulfide level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:15138 ! sulfide(2-) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:15138 ! sulfide(2-) created_by: midori creation_date: 2012-08-16T16:54:55Z [Term] id: FYPO:0001413 name: increased cellular sulfide level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of sulfide (S2-, also called acid labile sulfide) measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular acid labile sulfide level" EXACT [PomBase:al] synonym: "increased cellular sulfide accumulation" RELATED [PomBase:mah] synonym: "increased cellular sulfide ion level" EXACT [PomBase:mah] synonym: "increased cellular sulfide level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular sulfide level during vegetative growth" EXACT [PomBase:mah] synonym: "increased cellular sulphide level" EXACT [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth is_a: FYPO:0001411 ! altered cellular sulfide level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:15138 ! sulfide(2-) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:15138 ! sulfide(2-) created_by: midori creation_date: 2012-08-16T16:56:12Z [Term] id: FYPO:0001414 name: sensitive to sulfide def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to sulfide (S2-). Cells stop growing (and may die) at a concentration of sulfide ions that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to sulfide" EXACT [PomBase:mah] synonym: "sensitive to sulfide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to sulfide during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to sulphide" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:15138 ! sulfide(2-) relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:15138 ! sulfide(2-) created_by: midori creation_date: 2012-08-16T17:01:57Z [Term] id: FYPO:0001415 name: abnormal sulfide:quinone oxidoreductase activity def: "A molecular function phenotype in which the observed rate of sulfide:quinone oxidoreductase activity is abnormal." [PomBase:mah] synonym: "abnormal sulfide-quinone reductase activity" EXACT [GO:0070224] synonym: "abnormal sulfide:quinone reductase activity" EXACT [PomBase:al] synonym: "abnormal sulphide:quinone oxidoreductase activity" EXACT [PomBase:mah] is_a: FYPO:0000689 ! abnormal oxidoreductase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0070224 ! sulfide:quinone oxidoreductase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0070224 ! sulfide:quinone oxidoreductase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-16T17:02:48Z [Term] id: FYPO:0001416 name: decreased sulfide:quinone oxidoreductase activity def: "A molecular function phenotype in which the observed rate of sulfide:quinone oxidoreductase activity is decreased." [PomBase:mah] synonym: "decreased sulfide-quinone reductase activity" EXACT [GO:0070224] synonym: "decreased sulfide:quinone reductase activity" EXACT [PomBase:al] synonym: "decreased sulphide:quinone oxidoreductase activity" EXACT [PomBase:mah] synonym: "reduced sulfide:quinone oxidoreductase activity" EXACT [PomBase:mah] is_a: FYPO:0000690 ! decreased oxidoreductase activity is_a: FYPO:0001415 ! abnormal sulfide:quinone oxidoreductase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0070224 ! sulfide:quinone oxidoreductase activity relationship: inheres_in GO:0070224 ! sulfide:quinone oxidoreductase activity created_by: midori creation_date: 2012-08-16T17:03:37Z [Term] id: FYPO:0001417 name: mislocalized equatorial microtubule organizing center def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell forms an equatorial microtubule organizing center in an abnormal location. The normal location is at the center of the cell." [PomBase:mah] synonym: "mislocalised equatorial microtubule organizing center" EXACT [PomBase:mah] synonym: "mislocalized eMTOC" EXACT [GO:0000923] synonym: "mislocalized equatorial microtubule organizing center during mitotic cell cycle" RELATED [PomBase:mah] synonym: "mislocalized equatorial microtubule organizing center during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0004315 ! abnormal microtubule cytoskeleton during vegetative growth is_a: PATO:0000628 ! mislocalised intersection_of: PATO:0000628 ! mislocalised intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000923 ! equatorial microtubule organizing center relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000923 ! equatorial microtubule organizing center created_by: midori creation_date: 2012-08-22T11:59:56Z [Term] id: FYPO:0001418 name: abnormal microtubule cytoskeleton morphology during vegetative growth def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of the microtubule cytoskeleton is abnormal." [PomBase:mah] comment: Note that an abnormal microtubule cytoskeleton organization process may, but does not necessarily, result in abnormal microtubule cytoskeleton morphology. synonym: "abnormal microtubule cytoskeleton morphology during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000352 ! abnormal cytoskeleton morphology during vegetative growth is_a: FYPO:0003064 ! abnormal microtubule cytoskeleton morphology is_a: FYPO:0004315 ! abnormal microtubule cytoskeleton during vegetative growth intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0015630 ! microtubule cytoskeleton intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0015630 ! microtubule cytoskeleton relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-22T12:00:57Z [Term] id: FYPO:0001419 name: normal cell population growth rate def: "A cell population phenotype in which a population of cells grows at the same rate as wild type." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "normal growth rate" BROAD [PomBase:mah] is_a: FYPO:0002058 ! viable cell population created_by: midori creation_date: 2012-08-22T13:05:17Z [Term] id: FYPO:0001420 name: normal vegetative cell population growth rate def: "A cell population phenotype in which a population of cells grow at the same rate as wild type in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "normal growth rate" BROAD [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth is_a: FYPO:0001419 ! normal cell population growth rate is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-08-22T13:07:40Z [Term] id: FYPO:0001421 name: abnormal protein processing during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which protein processing is abnormal. Protein processing is the cleavage of one or more bonds within a protein that leads to the formation of mature, fully functional protein." [GO:0030163, PomBase:mah] synonym: "abnormal protein cleavage during vegetative growth" RELATED [PomBase:vw] synonym: "abnormal protein maturation by peptide bond cleavage during vegetative growth" EXACT [GO:0016485] synonym: "abnormal protein maturation by peptide bond hydrolysis during vegetative growth" EXACT [GO:0016485] synonym: "abnormal protein processing during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000328 ! abnormal protein metabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0016485 ! protein processing intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0016485 ! protein processing relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-22T13:47:53Z [Term] id: FYPO:0001422 name: decreased protein processing def: "A cellular metabolism phenotype observed in the vegetative growth phase of the life cycle in which the observed occurrence of protein processing is decreased." [PMID:19520858, PomBase:mah] synonym: "decreased protein cleavage" RELATED [PomBase:vw] synonym: "decreased protein maturation by peptide bond cleavage" EXACT [GO:0016485] synonym: "decreased protein maturation by peptide bond hydrolysis" EXACT [GO:0016485] synonym: "decreased protein processing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein processing during vegetative growth" EXACT [PomBase:mah] synonym: "decreased Sre1 cleavage" NARROW [PomBase:mah] synonym: "reduced protein processing" EXACT [PomBase:mah] is_a: FYPO:0001421 ! abnormal protein processing during vegetative growth is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0016485 ! protein processing relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0016485 ! protein processing created_by: midori creation_date: 2012-08-22T14:19:01Z [Term] id: FYPO:0001423 name: normal protein targeting to vacuole def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which protein targeting to the vacuole is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein targeting to vacuole during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein targeting to vacuole during vegetative growth" EXACT [PomBase:mah] synonym: "normal vacuolar protein sorting" EXACT [PomBase:mah] is_a: FYPO:0000601 ! normal vacuolar transport is_a: FYPO:0000644 ! normal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006623 ! protein targeting to vacuole intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006623 ! protein targeting to vacuole relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-08-22T14:28:30Z [Term] id: FYPO:0001424 name: abolished protein localization to nucleus during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleus is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to nucleus during vegetative growth" EXACT [PomBase:mah] synonym: "abolished protein localization to nucleus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein localization to nucleus abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001129 ! abnormal protein localization to nucleus during vegetative growth is_a: FYPO:0001179 ! protein localization abolished during vegetative growth is_a: FYPO:0003450 ! abolished protein localization to nucleus intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0034504 ! protein localization to nucleus relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0034504 ! protein localization to nucleus created_by: midori creation_date: 2012-08-22T14:54:11Z [Term] id: FYPO:0001425 name: abnormal negative regulation of mitotic DNA replication initiation resulting in complete rereplication def: "A regulation phenotype observed in the vegetative growth phase of the life cycle in which negative regulation of the initiation of mitotic DNA replication is abnormal, resulting in one or more rounds of rereplication of the entire genome." [PMID:10388806, PomBase:mah] comment: Consider also annotating to 'abnormal mitosis' (FYPO:0000337), 'inviable swollen elongated cell with enlarged nucleus' (FYPO:0002083), or both. If a cell undergoes several rounds of complete rereplication, the FYPO:0002083 phenotype usually results. synonym: "abnormal negative regulation of DNA replication initiation during vegetative growth, resulting in complete rereplication" EXACT [PomBase:mah] synonym: "abnormal negative regulation of DNA replication initiation resulting in complete rereplication during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal negative regulation of mitotic DNA replication initiation resulting in complete re-replication" EXACT [PomBase:mah] synonym: "complete mitotic DNA re-replication" RELATED [PomBase:mah] synonym: "complete mitotic DNA rereplication" RELATED [PomBase:mah] is_a: FYPO:0000216 ! abnormal negative regulation of mitotic DNA replication initiation relationship: has_output FYPO:0000158 ! DNA content increased during vegetative growth created_by: midori creation_date: 2012-08-22T15:01:52Z [Term] id: FYPO:0001426 name: abnormal negative regulation of mitotic DNA replication initiation resulting in partial rereplication def: "A regulation phenotype observed in the vegetative growth phase of the life cycle in which negative regulation of the initiation of mitotic DNA replication is abnormal, resulting in rereplication of part of the genome." [PMID:10388806, PomBase:mah] synonym: "abnormal negative regulation of DNA replication initiation during vegetative growth, resulting in partial rereplication" EXACT [PomBase:mah] synonym: "abnormal negative regulation of DNA replication initiation resulting in partial rereplication during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal negative regulation of mitotic DNA replication initiation resulting in partial re-replication" EXACT [PomBase:mah] synonym: "partial mitotic DNA re-replication" RELATED [PomBase:mah] synonym: "partial mitotic DNA rereplication" RELATED [PomBase:mah] is_a: FYPO:0000216 ! abnormal negative regulation of mitotic DNA replication initiation relationship: has_output FYPO:0000158 ! DNA content increased during vegetative growth created_by: midori creation_date: 2012-08-22T15:05:13Z [Term] id: FYPO:0001427 name: abnormal negative regulation of mitotic DNA replication initiation resulting in slow rereplication def: "A regulation phenotype observed in the vegetative growth phase of the life cycle in which negative regulation of the initiation of mitotic DNA replication is abnormal, resulting in a single round of rereplication of the entire genome, which takes place more slowly than normal replication." [PMID:10388806, PomBase:mah] synonym: "abnormal negative regulation of DNA replication initiation during vegetative growth, resulting in slow rereplication" EXACT [PomBase:mah] synonym: "abnormal negative regulation of DNA replication initiation resulting in slow rereplication during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal negative regulation of mitotic DNA replication initiation resulting in slow re-replication" EXACT [PomBase:mah] synonym: "slow mitotic DNA re-replication" RELATED [PomBase:mah] synonym: "slow mitotic DNA rereplication" RELATED [PomBase:mah] is_a: FYPO:0000216 ! abnormal negative regulation of mitotic DNA replication initiation relationship: has_output FYPO:0000158 ! DNA content increased during vegetative growth created_by: midori creation_date: 2012-08-22T15:06:50Z [Term] id: FYPO:0001428 name: normal negative regulation of mitotic DNA replication initiation def: "A regulation phenotype observed in the vegetative growth phase of the life cycle in which negative regulation of the initiation of mitotic DNA replication is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal negative regulation of DNA replication initiation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal negative regulation of DNA replication initiation during vegetative growth" EXACT [PomBase:mah] synonym: "normal negative regulation of initiation of DNA replication initiation" EXACT [PomBase:mah] is_a: FYPO:0001928 ! normal regulation of mitotic cell cycle is_a: FYPO:0002995 ! normal regulation of DNA replication intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903467 ! negative regulation of mitotic DNA replication initiation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903467 ! negative regulation of mitotic DNA replication initiation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-08-22T15:08:32Z [Term] id: FYPO:0001429 name: swollen elongated cell def: "A cell morphology phenotype in which a cell has a larger volume, greater length, greater diameter, and greater length:width ratio than normal." [PMID:10388806, PomBase:mah] comment: The distinction between this phenotype and centrally constricted (dumbbell-shaped) cells (FYPO:0000779) is that swollen elongated cells do not have a constriction along the long axis. Swollen elongated cells may have a uniform diameter, or may be swollen only around the nucleus. synonym: "elongated cell with increased cell volume" EXACT [PomBase:mah] synonym: "enlarged elongated cell" RELATED [PomBase:mah] synonym: "large elongated cell" RELATED [PomBase:vw] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000025 ! swollen cell relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000025 ! swollen cell created_by: midori creation_date: 2012-08-22T15:16:12Z [Term] id: FYPO:0001430 name: abnormal mitotic cell cycle arrest with unreplicated DNA def: "A cellular process phenotype in which progression through the mitotic cell cycle is arrested before cells have replicated genomic DNA, under conditions where arrest does not normally occur." [PomBase:mah] comment: Arrest with unreplicated DNA may occur between mitosis and the beginning of S phase; if only DNA content is measured, the arrest point cannot be determined with greater precision. synonym: "abnormal mitotic cell cycle arrest with 1C DNA content" NARROW [PomBase:mah] synonym: "abnormal mitotic cell cycle arrest with unreplicated DNA" EXACT [PomBase:mah] synonym: "abnormal mitotic cell cycle arrest with unreplicated DNA during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000502 ! abnormally arrested mitotic cell cycle progression is_a: FYPO:0004040 ! mitotic cell cycle arrest phenotype intersection_of: inheres_in GO:0071850 ! mitotic cell cycle arrest intersection_of: precedes GO:0033260 ! nuclear DNA replication intersection_of: qualifier PATO:0000467 ! present relationship: inheres_in GO:0071850 ! mitotic cell cycle arrest relationship: precedes GO:0033260 ! nuclear DNA replication relationship: qualifier PATO:0000467 ! present created_by: midori creation_date: 2012-08-22T15:27:17Z [Term] id: FYPO:0001431 name: resistance to Dio-9 def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of the antibiotic Dio-9 than normal." [PomBase:mah] comment: DIO 9 has CAS registry number 11006-20-5. synonym: "resistance to DIO 9" EXACT [PomBase:mah] synonym: "resistance to Dio-9 during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to Dio-9 during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to Dio-9" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth created_by: midori creation_date: 2012-08-23T12:22:31Z [Term] id: FYPO:0001432 name: resistance to ethidium bromide def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of ethidium bromide than normal." [PomBase:mah] synonym: "resistance to EtBr" EXACT [PomBase:mah] synonym: "resistance to ethidium bromide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to ethidium bromide during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to ethidium bromide" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:4883 ! ethidium bromide relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:4883 ! ethidium bromide created_by: midori creation_date: 2012-08-23T12:45:11Z [Term] id: FYPO:0001433 name: resistance to decamethylenediguanidine def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of decamethylenediguanidine than normal." [PomBase:mah] synonym: "resistance to Anticoman" EXACT [CHEBI:768260, PomBase:mah] synonym: "resistance to decamethylenediguanidine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to decamethylenediguanidine during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to decamethylenediguanidine" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:84333 ! synthalin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:84333 ! synthalin created_by: midori creation_date: 2012-08-23T12:49:28Z [Term] id: FYPO:0001434 name: resistance to N,N'-(p-xylylidene)bis-aminoguanidine 2HCl def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of N,N'-(p-xylylidene)bis-aminoguanidine 2HCl than normal." [PomBase:mah] synonym: "resistance to N,N'-(p-xylylidene)bis-aminoguanidine 2HCl during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to N,N'-(p-xylylidene)bis-aminoguanidine 2HCl during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to N,N'-(p-xylylidene)bis-aminoguanidine 2HCl" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:67202 ! N,N'-(p-xylylidene)bis(aminoguanidine) dihydrochloride relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:67202 ! N,N'-(p-xylylidene)bis(aminoguanidine) dihydrochloride created_by: midori creation_date: 2012-08-23T12:50:30Z [Term] id: FYPO:0001435 name: normal growth on erythromycin def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing erythromycin." [PomBase:mah] synonym: "normal cell population growth in presence of erythromycin" EXACT [PomBase:mah] synonym: "normal cell population growth on erythromycin" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to erythromycin" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on erythromycin" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:48923 ! erythromycin relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:48923 ! erythromycin created_by: midori creation_date: 2012-08-23T12:53:50Z [Term] id: FYPO:0001436 name: normal growth on trichodermin def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing trichodermin." [PomBase:mah] synonym: "normal cell population growth in presence of trichodermin" EXACT [PomBase:mah] synonym: "normal cell population growth on trichodermin" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to trichodermin" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on trichodermin" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:9688 ! trichodermin relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:9688 ! trichodermin created_by: midori creation_date: 2012-08-23T12:55:40Z [Term] id: FYPO:0001437 name: normal growth on antimycin A def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing antimycin A." [PomBase:mah] synonym: "normal cell population growth in presence of antimycin A" EXACT [PomBase:mah] synonym: "normal cell population growth on antimycin A" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to antimycin A" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on antimycin A" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:22584 ! antimycin A relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:22584 ! antimycin A created_by: midori creation_date: 2012-08-23T12:56:12Z [Term] id: FYPO:0001438 name: normal growth on tetracycline def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing tetracycline." [PomBase:mah] synonym: "normal cell population growth in presence of tetracycline" EXACT [PomBase:mah] synonym: "normal cell population growth on tetracycline" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to tetracycline" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on tetracycline" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:27902 ! tetracycline relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:27902 ! tetracycline created_by: midori creation_date: 2012-08-23T12:58:33Z [Term] id: FYPO:0001439 name: normal growth on chloramphenicol def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing chloramphenicol." [PomBase:mah] synonym: "normal cell population growth in presence of chloramphenicol" EXACT [PomBase:mah] synonym: "normal cell population growth on chloramphenicol" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to chloramphenicol" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on chloramphenicol" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:17698 ! chloramphenicol relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:17698 ! chloramphenicol created_by: midori creation_date: 2012-08-23T12:59:01Z [Term] id: FYPO:0001440 name: abnormal protein complex localization def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein complex is abnormal." [PomBase:mah] synonym: "abnormal cellular protein complex localization" EXACT [GO:0034629, PomBase:mah] synonym: "abnormal protein complex localisation" EXACT [GO:0034629, PomBase:mah] synonym: "abnormal protein complex localization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein complex localization during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001370 ! abnormal protein localization intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0034629 ! cellular protein complex localization intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0034629 ! cellular protein complex localization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-23T14:24:05Z [Term] id: FYPO:0001441 name: decreased SAGA complex localization to promoter region def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the cell cortex is decreased." [PomBase:mah] synonym: "decreased SAGA complex localisation to promoter region" EXACT [PomBase:mah] synonym: "decreased SAGA complex localization to promoter region during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased SAGA complex localization to promoter region during vegetative growth" EXACT [PomBase:mah] synonym: "decreased SAGA complex localization to transcription regulatory region" EXACT [GO:0072742, PomBase:mah] synonym: "decreased SAGA complex recruitment" EXACT [GO:0072742, PomBase:mah] synonym: "reduced SAGA complex localization to promoter region" EXACT [PomBase:mah] synonym: "reduced SAGA complex recruitment" EXACT [PomBase:vw] is_a: FYPO:0000443 ! abnormal protein localization during vegetative growth is_a: FYPO:0001440 ! abnormal protein complex localization is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072742 ! SAGA complex localization to transcription regulatory region relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072742 ! SAGA complex localization to transcription regulatory region created_by: midori creation_date: 2012-08-23T14:34:58Z [Term] id: FYPO:0001442 name: decreased histone H3-K9 acetylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which acetylation of lysine at position 9 of histone H3 occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased histone H3 K9 acetylation" EXACT [GO:0043970, PomBase:mah] synonym: "decreased histone H3-K9 acetylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H3-K9 acetylation during vegetative growth" EXACT [PomBase:mah] synonym: "decreased histone lysine H3 K9 acetylation" EXACT [GO:0043970, PomBase:mah] synonym: "reduced histone H3-K9 acetylation" EXACT [PomBase:mah] is_a: FYPO:0000891 ! abnormal histone H3-K9 acetylation is_a: FYPO:0002362 ! decreased histone H3 acetylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0043970 ! histone H3-K9 acetylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0043970 ! histone H3-K9 acetylation created_by: midori creation_date: 2012-08-23T14:45:03Z [Term] id: FYPO:0001443 name: abolished transcription during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription does not occur. All genes, or a specific subset of genes, may be affected." [PomBase:mah] synonym: "abolished transcription during mitotic cell cycle" RELATED [PomBase:mah] synonym: "transcription abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000781 ! decreased transcription during vegetative growth is_a: FYPO:0002877 ! abolished transcription intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0006351 ! transcription, DNA-templated relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0006351 ! transcription, DNA-templated created_by: midori creation_date: 2012-08-23T14:53:02Z [Term] id: FYPO:0001444 name: increased cellular trehalose level during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of trehalose measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular trehalose level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased trehalose accumulation during vegetative growth" RELATED [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth is_a: FYPO:0002685 ! increased cellular trehalose level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:27082 ! trehalose relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:27082 ! trehalose created_by: midori creation_date: 2012-08-23T15:18:12Z [Term] id: FYPO:0001445 name: increased cellular trehalose level during heat shock def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of trehalose measured in a cell is higher than normal when the cell is subject to heat shock." [PomBase:mah] synonym: "increased cellular trehalose level during heat shock during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular trehalose level during vegetative growth and during heat shock" EXACT [PomBase:mah] synonym: "increased trehalose accumulation during heat shock" RELATED [PomBase:mah] is_a: FYPO:0001444 ! increased cellular trehalose level during vegetative growth created_by: midori creation_date: 2012-08-23T15:19:11Z [Term] id: FYPO:0001446 name: altered cellular trehalose level def: "A cell phenotype in which the amount of trehalose measured in a cell differs from normal." [PomBase:mah] synonym: "abnormal cellular trehalose accumulation" RELATED [PomBase:mah] synonym: "abnormal cellular trehalose level" EXACT [PomBase:mah] is_a: FYPO:0000989 ! altered level of substance in cell intersection_of: PATO:0001159 ! concentrated intersection_of: inheres_in CL:0000000 ! cell intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:27082 ! trehalose relationship: inheres_in CL:0000000 ! cell relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:27082 ! trehalose created_by: midori creation_date: 2012-08-23T15:22:37Z [Term] id: FYPO:0001447 name: decreased cellular trehalose level def: "A cell phenotype in which the amount of trehalose measured in a cell is lower than normal." [PomBase:mah] synonym: "decreased cellular trehalose accumulation" RELATED [PomBase:mah] synonym: "reduced cellular trehalose level" EXACT [PomBase:mah] is_a: FYPO:0000991 ! decreased level of substance in cell is_a: FYPO:0001446 ! altered cellular trehalose level intersection_of: PATO:0001163 ! decreased concentration intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:27082 ! trehalose relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:27082 ! trehalose created_by: midori creation_date: 2012-08-23T15:24:19Z [Term] id: FYPO:0001448 name: trehalose absent from cell during heat shock def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of trehalose measured in a cell is too low to detect." [PomBase:mah] synonym: "absent trehalose" EXACT [PomBase:al] synonym: "trehalose absent from cell during heat shock during mitotic cell cycle" RELATED [PomBase:mah] synonym: "trehalose absent from cell during vegetative growth and during heat shock" EXACT [PomBase:mah] is_a: FYPO:0001323 ! altered level of substance in cell during vegetative growth is_a: FYPO:0001446 ! altered cellular trehalose level created_by: midori creation_date: 2012-08-23T15:26:41Z [Term] id: FYPO:0001449 name: normal cellular trehalose level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of trehalose measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular trehalose accumulation" RELATED [PomBase:mah] synonym: "normal cellular trehalose level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular trehalose level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:27082 ! trehalose relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:27082 ! trehalose created_by: midori creation_date: 2012-08-23T15:28:23Z [Term] id: FYPO:0001450 name: resistance to cold def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which cells show decreased sensitivity to cold." [PomBase:mah] synonym: "resistance to cold during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to cold during vegetative growth" EXACT [PomBase:mah] synonym: "resistance to low temperature" EXACT [PomBase:mah] synonym: "resistant to cold" EXACT [PomBase:mah] is_a: FYPO:0000850 ! resistance to stress during vegetative growth created_by: midori creation_date: 2012-08-23T15:46:25Z [Term] id: FYPO:0001451 name: resistance to freezing def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which cells show decreased sensitivity to freezing." [PomBase:mah] synonym: "resistance to freezing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to freezing during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to freeze-thawing" RELATED [PomBase:al] synonym: "resistant to freezing" EXACT [PomBase:mah] is_a: FYPO:0001450 ! resistance to cold created_by: midori creation_date: 2012-08-23T15:47:42Z [Term] id: FYPO:0001452 name: resistance to water deprivation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which cells show decreased sensitivity to water deprivation." [PomBase:mah] synonym: "resistance to water deprivation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to water deprivation during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to dehydration" EXACT [GO:0009414, PomBase:al] synonym: "resistant to water deprivation" EXACT [PomBase:mah] is_a: FYPO:0000850 ! resistance to stress during vegetative growth created_by: midori creation_date: 2012-08-23T15:49:03Z [Term] id: FYPO:0001453 name: resistance to ethanol def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of ethanol than normal." [PomBase:mah] synonym: "resistance to ethanol during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to ethanol during vegetative growth" EXACT [PomBase:mah] synonym: "resistance to ethyl alcohol" EXACT [CHEBI:16236] synonym: "resistant to ethanol" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:16236 ! ethanol relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:16236 ! ethanol created_by: midori creation_date: 2012-08-23T15:50:53Z [Term] id: FYPO:0001454 name: normal during cellular response to freezing def: "A cell growth phenotype in which cell population growth is normal (i.e. indistinguishable from wild type) during a cellular response to freezing conditions." [PomBase:mah] synonym: "normal cell population growth during cellular response to freezing" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to freeze-thawing" RELATED [PomBase:al] synonym: "normal cellular response to freezing" RELATED [PomBase:mah] synonym: "normal vegetative cell population growth during cellular response to freezing" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: happens_during GO:0071497 ! cellular response to freezing relationship: happens_during GO:0071497 ! cellular response to freezing created_by: midori creation_date: 2012-08-23T15:54:30Z [Term] id: FYPO:0001455 name: normal cellular response to water deprivation def: "A cellular response phenotype observed in the vegetative growth phase of the life cycle in which the cellular response to water deprivation is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular response to dehydration" EXACT [GO:0009414, GO:0042631, PomBase:al] synonym: "normal cellular response to water deprivation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular response to water deprivation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000968 ! normal cellular response to stress is_a: FYPO:0001318 ! normal cellular response to chemical stimulus during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0042631 ! cellular response to water deprivation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0042631 ! cellular response to water deprivation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-08-23T15:58:02Z [Term] id: FYPO:0001456 name: increased RNA level during cellular response to endoplasmic reticulum stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to endoplasmic reticulum stress is higher than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "increased mRNA level during cellular response to endoplasmic reticulum stress" NARROW [PomBase:mah] synonym: "increased RNA accumulation during cellular response to endoplasmic reticulum stress" RELATED [PomBase:mah] synonym: "increased RNA level during cellular response to endoplasmic reticulum stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased RNA level during cellular response to endoplasmic reticulum stress during vegetative growth" EXACT [PomBase:mah] synonym: "increased RNA level during response to ER stress" EXACT [GO:0034976, PomBase:mah] synonym: "increased RNA level under ER stress-inducing conditions" RELATED [PomBase:vw] synonym: "increased transcript level during cellular response to endoplasmic reticulum stress" EXACT [PomBase:vw] is_a: FYPO:0000825 ! increased RNA level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0034976 ! response to endoplasmic reticulum stress intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0034976 ! response to endoplasmic reticulum stress relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2012-08-23T16:26:07Z [Term] id: FYPO:0001457 name: sensitive to tunicamycin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to tunicamycin. Cells stop growing (and may die) at a concentration of tunicamycin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to tunicamycin" EXACT [PomBase:mah] synonym: "sensitive to tunicamycin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to tunicamycin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:29699 ! tunicamycin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:29699 ! tunicamycin created_by: midori creation_date: 2012-08-23T16:33:02Z [Term] id: FYPO:0001458 name: decreased histone H3-K14 acetylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which acetylation of lysine at position 14 of histone H3 occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased histone H3 K14 acetylation" EXACT [GO:0044154, PomBase:mah] synonym: "decreased histone H3-K14 acetylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H3-K14 acetylation during vegetative growth" EXACT [PomBase:mah] synonym: "decreased histone lysine H3 K14 acetylation" EXACT [GO:0044154, PomBase:mah] synonym: "reduced histone H3-K14 acetylation" EXACT [PomBase:mah] is_a: FYPO:0000788 ! abnormal histone H3-K14 acetylation is_a: FYPO:0002362 ! decreased histone H3 acetylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0044154 ! histone H3-K14 acetylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0044154 ! histone H3-K14 acetylation created_by: midori creation_date: 2012-08-24T14:22:25Z [Term] id: FYPO:0001459 name: increased basal transcription from CDRE promoter def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the level of transcription from a calcineurin-dependent response element (CDRE)-containing promoter is higher than normal in the absence of a calcium ion stimulus." [PMID:21811607, PomBase:mah] comment: This term was made obsolete because it did not define "basal" transcription sufficiently precisely. synonym: "increased basal transcription from CDRE promoter during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased basal transcription from CDRE promoter during vegetative growth" EXACT [PomBase:mah] synonym: "increased transcription from CRDE promoter in the absence of calcium" EXACT [PomBase:al] is_obsolete: true created_by: midori creation_date: 2012-08-29T14:03:47Z [Term] id: FYPO:0001460 name: increased transcription from CDRE promoter in response to calcium ion def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription from a calcineurin-dependent response element (CDRE)-containing promoter is increased following a calcium ion stimulus." [PMID:21811607, PomBase:mah] synonym: "increased transcription from CDRE promoter in response to calcium ion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased transcription from CDRE promoter in response to calcium ion during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000780 ! increased transcription during vegetative growth created_by: midori creation_date: 2012-08-29T14:14:33Z [Term] id: FYPO:0001461 name: normal immediate intracellular calcium spike following extracellular calcium stimulus def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the intracellular calcium ion (Ca2+) concentration briefly increases normally immediately following an extracellular Ca2+ stimulus. Normally, the intracellular Ca2+ concentration increases to a peak in a \"burst\" within one minute, and then decreases to a new steady-state concentration." [PMID:21811607, PomBase:mah] synonym: "normal immediate intracellular calcium spike following extracellular calcium stimulus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal immediate intracellular calcium spike following extracellular calcium stimulus during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001199 ! normal cellular calcium level created_by: midori creation_date: 2012-08-29T14:47:54Z [Term] id: FYPO:0001462 name: altered cellular calcium level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of calcium ion measured in a cell differs from normal." [PomBase:mah] synonym: "abnormal cellular calcium accumulation" RELATED [PomBase:mah] synonym: "abnormal cellular calcium level" EXACT [PomBase:mah] synonym: "altered cellular calcium ion level" EXACT [PomBase:mah] synonym: "altered cellular calcium level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "altered cellular calcium level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001323 ! altered level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:29108 ! calcium(2+) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:29108 ! calcium(2+) created_by: midori creation_date: 2012-08-29T14:51:00Z [Term] id: FYPO:0001463 name: abnormal immediate intracellular calcium spike following extracellular calcium stimulus def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the intracellular calcium ion (Ca2+) concentration briefly increases abnormally, or does not change, immediately following an extracellular Ca2+ stimulus. Normally, the intracellular Ca2+ concentration increases to a peak in a \"burst\" within one minute, and then decreases to a new steady-state concentration." [PMID:21811607, PomBase:mah] synonym: "abnormal immediate intracellular calcium spike following extracellular calcium stimulus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal immediate intracellular calcium spike following extracellular calcium stimulus during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001462 ! altered cellular calcium level created_by: midori creation_date: 2012-08-29T14:59:29Z [Term] id: FYPO:0001464 name: increased immediate intracellular calcium spike following extracellular calcium stimulus def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the intracellular calcium ion (Ca2+) concentration briefly increases to a greater extent than normal immediately following an extracellular Ca2+ stimulus. Normally, the intracellular Ca2+ concentration increases to a peak in a \"burst\" within one minute, and then decreases to a new steady-state concentration." [PMID:21811607, PomBase:mah] comment: This term was made obsolete because it does not accurately describe an observed phenotype. synonym: "increased immediate intracellular calcium spike following extracellular calcium stimulus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased immediate intracellular calcium spike following extracellular calcium stimulus during vegetative growth" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2012-08-29T15:00:24Z [Term] id: FYPO:0001465 name: decreased immediate intracellular calcium spike following extracellular calcium stimulus def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the intracellular calcium ion (Ca2+) concentration briefly increases to a lesser extent than normal immediately following an extracellular Ca2+ stimulus. Normally, the intracellular Ca2+ concentration increases to a peak in a \"burst\" within one minute, and then decreases to a new steady-state concentration." [PMID:21811607, PomBase:mah] synonym: "decreased immediate intracellular calcium spike following extracellular calcium stimulus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased immediate intracellular calcium spike following extracellular calcium stimulus during vegetative growth" EXACT [PomBase:mah] synonym: "reduced immediate intracellular calcium spike following extracellular calcium stimulus" EXACT [PomBase:mah] is_a: FYPO:0001463 ! abnormal immediate intracellular calcium spike following extracellular calcium stimulus created_by: midori creation_date: 2012-08-29T15:03:36Z [Term] id: FYPO:0001466 name: abolished immediate intracellular calcium spike following extracellular calcium stimulus def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the intracellular calcium ion (Ca2+) concentration does not increase immediately following an extracellular Ca2+ stimulus. Normally, the intracellular Ca2+ concentration increases to a peak in a \"burst\" within one minute, and then decreases to a new steady-state concentration." [PMID:21811607, PomBase:mah] synonym: "abolished immediate intracellular calcium spike following extracellular calcium stimulus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "immediate intracellular calcium spike following extracellular calcium stimulus abolished" EXACT [PomBase:mah] synonym: "immediate intracellular calcium spike following extracellular calcium stimulus abolished during vegetative growth" EXACT [PomBase:mah] synonym: "immediate intracellular calcium spike following extracellular calcium stimulus absent" EXACT [PomBase:mah] is_a: FYPO:0001463 ! abnormal immediate intracellular calcium spike following extracellular calcium stimulus created_by: midori creation_date: 2012-08-29T15:32:06Z [Term] id: FYPO:0001467 name: normal increase in steady-state intracellular calcium level following extracellular calcium stimulus def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the steady-state intracellular calcium ion (Ca2+) concentration increases normally following an extracellular Ca2+ stimulus. Normally, a dose-dependent increased steady-state Ca2+ concentration is reached within 2-3 minutes of extracellular Ca2+ addition, and is sustained for several hours." [PMID:21811607, PomBase:mah] comment: This term was made obsolete because it does not accurately describe an observed phenotype. synonym: "normal increase in steady-state intracellular calcium level following extracellular calcium stimulus" EXACT [PomBase:mah] synonym: "normal increase in steady-state intracellular calcium level following extracellular calcium stimulus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal increase in steady-state intracellular calcium level following extracellular calcium stimulus during vegetative growth" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2012-08-29T15:52:34Z [Term] id: FYPO:0001468 name: abnormal steady-state intracellular calcium level following extracellular calcium stimulus def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the steady-state intracellular calcium ion (Ca2+) concentration increases abnormally, or does not change, following an extracellular Ca2+ stimulus. Normally, a dose-dependent increased steady-state Ca2+ concentration is reached within 2-3 minutes of extracellular Ca2+ addition, and is sustained for several hours." [PMID:21811607, PomBase:mah] synonym: "abnormal increase in steady-state intracellular calcium level following extracellular calcium stimulus" EXACT [PomBase:mah] synonym: "abnormal increase in steady-state intracellular calcium level following extracellular calcium stimulus during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal steady-state intracellular calcium level following extracellular calcium stimulus during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001462 ! altered cellular calcium level created_by: midori creation_date: 2012-08-29T15:54:22Z [Term] id: FYPO:0001469 name: increased steady-state intracellular calcium level following extracellular calcium stimulus def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the steady-state intracellular calcium ion (Ca2+) concentration increases to a greater extent than normal following an extracellular Ca2+ stimulus. Normally, a dose-dependent increased steady-state Ca2+ concentration is reached within 2-3 minutes of extracellular Ca2+ addition, and is sustained for several hours." [PMID:21811607, PomBase:mah] synonym: "greater increase in steady-state intracellular calcium level following extracellular calcium stimulus during vegetative growth" EXACT [PomBase:mah] synonym: "increased steady-state intracellular calcium level following extracellular calcium stimulus during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001468 ! abnormal steady-state intracellular calcium level following extracellular calcium stimulus created_by: midori creation_date: 2012-08-29T15:55:25Z [Term] id: FYPO:0001470 name: normal growth on tacrolimus def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing tacrolimus." [PomBase:mah] synonym: "normal cell population growth in presence of tacrolimus" EXACT [PomBase:mah] synonym: "normal cell population growth on tacrolimus" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to FK506" EXACT [CHEBI:61057] synonym: "normal cellular response to tacrolimus" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on tacrolimus" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:61057 ! tacrolimus hydrate relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:61057 ! tacrolimus hydrate created_by: midori creation_date: 2012-08-29T16:03:18Z [Term] id: FYPO:0001471 name: normal growth on tacrolimus during salt stress def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing tacrolimus, when the cell is subject to salt stress." [PomBase:mah] synonym: "normal cell population growth in presence of tacrolimus during salt stress" EXACT [PomBase:mah] synonym: "normal cell population growth on FK506 during salt stress" EXACT [CHEBI:61057] synonym: "normal cell population growth on tacrolimus during salt stress" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to salt stress and tacrolimus" RELATED [PomBase:al] synonym: "normal cellular response to tacrolimus and salt stress" RELATED [PomBase:al] synonym: "normal cellular response to tacrolimus during salt stress" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on tacrolimus during salt stress" EXACT [PomBase:mah] is_a: FYPO:0001037 ! normal growth during cellular response to salt stress is_a: FYPO:0001472 ! normal growth on tacrolimus during osmotic stress intersection_of: FYPO:0001470 ! normal growth on tacrolimus intersection_of: happens_during GO:0071472 ! cellular response to salt stress relationship: happens_during GO:0071472 ! cellular response to salt stress created_by: midori creation_date: 2012-08-29T16:04:35Z [Term] id: FYPO:0001472 name: normal growth on tacrolimus during osmotic stress def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing tacrolimus, when the cell is subject to osmotic stress." [PomBase:mah] synonym: "normal cell population growth in presence of tacrolimus during osmotic stress" EXACT [PomBase:mah] synonym: "normal cell population growth on tacrolimus and sorbitol" NARROW [PomBase:al] synonym: "normal cell population growth on tacrolimus during osmotic stress" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to FK506 during osmotic stress" EXACT [CHEBI:61057] synonym: "normal cellular response to tacrolimus and osmotic stress" RELATED [PomBase:al] synonym: "normal cellular response to tacrolimus and sorbitol" RELATED [PomBase:al] synonym: "normal cellular response to tacrolimus during osmotic stress" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on tacrolimus during osmotic stress" EXACT [PomBase:mah] is_a: FYPO:0001021 ! normal growth during cellular response to osmotic stress is_a: FYPO:0001470 ! normal growth on tacrolimus intersection_of: FYPO:0001470 ! normal growth on tacrolimus intersection_of: happens_during GO:0071470 ! cellular response to osmotic stress relationship: happens_during GO:0071470 ! cellular response to osmotic stress created_by: midori creation_date: 2012-08-29T16:08:07Z [Term] id: FYPO:0001473 name: resistance to tacrolimus during salt stress def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of tacrolimus than normal when the cells are subject to salt stress." [PomBase:mah] synonym: "resistance to FK506 during salt stress" EXACT [CHEBI:61057, PomBase:mah] synonym: "resistance to salt stress and tacrolimus" EXACT [PomBase:al] synonym: "resistance to tacrolimus and salt stress" EXACT [PomBase:al] synonym: "resistance to tacrolimus during salt stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to tacrolimus during salt stress during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to tacrolimus" EXACT [PomBase:mah] is_a: FYPO:0001379 ! resistance to tacrolimus intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: during GO:0071472 ! cellular response to salt stress intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:61057 ! tacrolimus hydrate relationship: during GO:0071472 ! cellular response to salt stress relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:61057 ! tacrolimus hydrate created_by: midori creation_date: 2012-08-29T16:11:06Z [Term] id: FYPO:0001474 name: abnormal spindle pole body morphology during vegetative growth def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of the spindle pole body is abnormal." [PomBase:mah] comment: Note that an abnormal spindle pole body organization process may, but does not necessarily, result in abnormal spindle pole body structure. synonym: "abnormal SPB morphology during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal spindle pole body morphology during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal spindle pole body structure during vegetative growth" NARROW [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: FYPO:0004607 ! abnormal spindle pole body morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005816 ! spindle pole body intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005816 ! spindle pole body relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-29T16:52:01Z [Term] id: FYPO:0001475 name: fragmented spindle pole body def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the spindle pole body is broken into fragments." [PomBase:mah] synonym: "fragmented SPB" EXACT [PomBase:mah] synonym: "fragmented spindle pole body during mitotic cell cycle" RELATED [PomBase:mah] synonym: "fragmented spindle pole body during vegetative growth" EXACT [PomBase:mah] synonym: "spindle pole body fragmentation" EXACT [PomBase:vw] is_a: FYPO:0001474 ! abnormal spindle pole body morphology during vegetative growth is_a: PATO:0001444 ! broken intersection_of: PATO:0001444 ! broken intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005816 ! spindle pole body relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005816 ! spindle pole body created_by: midori creation_date: 2012-08-29T16:52:11Z [Term] id: FYPO:0001476 name: abnormal guanosine-diphosphatase activity def: "A molecular function phenotype in which the observed rate of guanosine-diphosphatase activity is abnormal." [PomBase:mah] synonym: "abnormal GDPase activity" EXACT [GO:0004382, PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004382 ! guanosine-diphosphatase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004382 ! guanosine-diphosphatase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-30T11:37:58Z [Term] id: FYPO:0001477 name: decreased guanosine-diphosphatase activity def: "A molecular function phenotype in which the observed rate of guanosine-diphosphatase activity is decreased." [PomBase:mah] synonym: "decreased GDPase activity" EXACT [GO:0004382, PomBase:mah] synonym: "reduced guanosine-diphosphatase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0001476 ! abnormal guanosine-diphosphatase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004382 ! guanosine-diphosphatase activity relationship: inheres_in GO:0004382 ! guanosine-diphosphatase activity created_by: midori creation_date: 2012-08-30T11:38:10Z [Term] id: FYPO:0001478 name: increased guanosine-diphosphatase activity def: "A molecular function phenotype in which the observed rate of guanosine-diphosphatase activity is increased." [PomBase:mah] synonym: "increased GDPase activity" EXACT [GO:0004382, PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0001476 ! abnormal guanosine-diphosphatase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0004382 ! guanosine-diphosphatase activity relationship: inheres_in GO:0004382 ! guanosine-diphosphatase activity created_by: midori creation_date: 2012-08-30T11:38:17Z [Term] id: FYPO:0001479 name: abnormal alpha,alpha-trehalase activity def: "A molecular function phenotype in which the observed rate of alpha,alpha-trehalase activity is abnormal." [PomBase:mah] synonym: "abnormal neutral trehalase activity" EXACT [PMID:9729425, PomBase:mah] synonym: "abnormal trehalase activity" BROAD [GO:0004555, GO:0015927] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004555 ! alpha,alpha-trehalase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004555 ! alpha,alpha-trehalase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-30T11:47:38Z [Term] id: FYPO:0001480 name: normal alpha,alpha-trehalase activity def: "A molecular function phenotype in which the observed rate of alpha,alpha-trehalase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal neutral trehalase activity" EXACT [PMID:9729425, PomBase:mah] synonym: "normal trehalase activity" BROAD [GO:0004555, GO:0015927] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004555 ! alpha,alpha-trehalase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0004555 ! alpha,alpha-trehalase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-08-30T12:05:18Z [Term] id: FYPO:0001481 name: alpha,alpha-trehalase activity increase abolished during cellular response to nutrient def: "A molecular function phenotype in which the observed rate of alpha,alpha-trehalase activity does not increase as a result of a nutrient stimulus." [PomBase:mah] synonym: "absent increase in trehalase activity following nutrient stimulus" EXACT [PomBase:al] synonym: "neutral trehalase activity increase abolished during cellular response to nutrient" EXACT [PMID:9729425, PomBase:mah] synonym: "trehalase activity increase abolished during cellular response to nutrient" BROAD [GO:0004555, GO:0015927] is_a: FYPO:0001479 ! abnormal alpha,alpha-trehalase activity is_a: FYPO:0001484 ! abnormal cellular response to nutrient created_by: midori creation_date: 2012-08-30T12:11:19Z [Term] id: FYPO:0001482 name: alpha,alpha-trehalase activity increase abolished during cellular response to heat def: "A molecular function phenotype in which the observed rate of alpha,alpha-trehalase activity does not increase as a result of a heat stimulus." [PomBase:mah] synonym: "absent increase in trehalase activity in response to high temperature" EXACT [PomBase:al] synonym: "neutral trehalase activity increase abolished during cellular response to heat" EXACT [PMID:9729425, PomBase:mah] synonym: "trehalase activity increase abolished during cellular response to heat" BROAD [GO:0004555, GO:0015927] is_a: FYPO:0000212 ! abnormal cellular response to heat is_a: FYPO:0001479 ! abnormal alpha,alpha-trehalase activity created_by: midori creation_date: 2012-08-30T12:15:03Z [Term] id: FYPO:0001483 name: normal alpha,alpha-trehalase activity increase during cellular response to oxidative stress def: "A molecular function phenotype in which the observed rate of alpha,alpha-trehalase activity increases normally (i.e. as in wild type) as a result of oxidative stress." [PomBase:mah] synonym: "normal increase in trehalase activity in response to oxidative stress" EXACT [PomBase:al] synonym: "normal neutral trehalase activity increase during cellular response to oxidative stress" EXACT [PMID:9729425, PomBase:mah] synonym: "normal trehalase activity increase during cellular response to oxidative stress" BROAD [GO:0004555, GO:0015927] is_a: FYPO:0001480 ! normal alpha,alpha-trehalase activity is_a: FYPO:0001485 ! normal cellular response to oxidative stress created_by: midori creation_date: 2012-08-30T12:18:52Z [Term] id: FYPO:0001484 name: abnormal cellular response to nutrient def: "A chemical response phenotype observed in the vegetative growth phase of the life cycle in which the cellular response to a nutrient is abnormal." [PomBase:mah] synonym: "abnormal cellular response to nutrient during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal cellular response to nutrient during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001342 ! cellular response phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0031670 ! cellular response to nutrient intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0031670 ! cellular response to nutrient relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-08-30T13:01:53Z [Term] id: FYPO:0001485 name: normal cellular response to oxidative stress def: "A cellular response phenotype observed in the vegetative growth phase of the life cycle in which the cellular response to oxidative stress is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular response to oxidative stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular response to oxidative stress during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000968 ! normal cellular response to stress is_a: FYPO:0001318 ! normal cellular response to chemical stimulus during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034599 ! cellular response to oxidative stress intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034599 ! cellular response to oxidative stress relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-08-30T13:03:23Z [Term] id: FYPO:0001486 name: normal RNA level during cellular response to salt stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to salt stress is normal (i.e. indistinguishable from wild type). Total RNA or a specific RNA may be affected." [PomBase:mah] comment: We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "normal mRNA level during cellular response to salt stress" NARROW [PomBase:mah] synonym: "normal RNA accumulation during cellular response to salt stress" RELATED [PomBase:mah] synonym: "normal RNA level during cellular response to salt stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal RNA level during cellular response to salt stress during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003793 ! normal RNA level during cellular response to osmotic stress intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0071472 ! cellular response to salt stress intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0071472 ! cellular response to salt stress relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2012-08-30T13:08:09Z [Term] id: FYPO:0001487 name: normal RNA level during cellular response to heat def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to heat is normal (i.e. indistinguishable from wild type). Total RNA or a specific RNA may be affected." [PomBase:mah] comment: We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "normal mRNA level during cellular response to heat" NARROW [PomBase:mah] synonym: "normal RNA accumulation during cellular response to heat" RELATED [PomBase:mah] synonym: "normal RNA level during cellular response to heat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal RNA level during cellular response to heat during vegetative growth" EXACT [PomBase:mah] synonym: "normal RNA level during cellular response to high temperature" EXACT [PomBase:al] is_a: FYPO:0001317 ! normal RNA level during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0034605 ! cellular response to heat intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0034605 ! cellular response to heat relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2012-08-30T13:09:03Z [Term] id: FYPO:0001488 name: sensitive to protamine sulfate def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to protamine sulfate. A protamine is any of a group of simple proteins that yield basic amino acids on hydrolysis, and forms a complex with heparin. Cells stop growing (and may die) at a concentration of protamine sulfate that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to protamine sulfate" EXACT [PomBase:mah] synonym: "sensitive to protamine sulfate during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to protamine sulfate during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to protamine sulphate" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth created_by: midori creation_date: 2012-08-30T13:32:12Z [Term] id: FYPO:0001489 name: inviable vegetative cell def: "A cell phenotype in which a cell is inviable in the phase of the life cycle during which wild type cells undergo vegetative growth." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "essential in vegetative cell" RELATED [PomBase:mah] synonym: "inviable cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000049 ! inviable cell is_a: FYPO:0001321 ! cellular physical quality phenotype during vegetative growth intersection_of: PATO:0000718 ! lethal (sensu genetics) intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) created_by: midori creation_date: 2012-08-30T13:59:02Z [Term] id: FYPO:0001490 name: inviable elongated vegetative cell def: "A cell morphology phenotype in which a vegetative cell is inviable and longer than normal." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "elongated inviable cell during vegetative growth" EXACT [PomBase:mah] synonym: "elongated inviable vegetative cell" EXACT [PomBase:mah] synonym: "essential; elongated vegetative cell" RELATED [PomBase:mah] synonym: "inviable elongated vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0002451 ! inviable vegetative cell with abnormal cell shape intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2012-08-30T14:08:27Z [Term] id: FYPO:0001491 name: viable vegetative cell def: "A cell phenotype in which a vegetatively growing cell is viable." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "viable cell during vegetative growth" EXACT [PomBase:mah] synonym: "viable vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000124 ! viable cell is_a: FYPO:0001321 ! cellular physical quality phenotype during vegetative growth intersection_of: PATO:0000719 ! viable intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) created_by: midori creation_date: 2012-08-30T14:12:48Z [Term] id: FYPO:0001492 name: viable elongated vegetative cell def: "A cell morphology phenotype in which a vegetative cell is viable and longer than normal." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "elongated viable vegetative cell" EXACT [PomBase:mah] synonym: "viable elongated cell during vegetative growth" EXACT [PomBase:mah] synonym: "viable elongated vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0002197 ! viable vegetative cell with abnormal cell shape intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0001491 ! viable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0001491 ! viable vegetative cell created_by: midori creation_date: 2012-08-30T14:17:56Z [Term] id: FYPO:0001493 name: inviable elongated multinucleate vegetative cell def: "A cell morphology phenotype in which a vegetative cell is inviable, longer than normal, and contains more than one nucleus apiece." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "elongated inviable multinucleate cell during vegetative growth" EXACT [PomBase:mah] synonym: "elongated multinucleate inviable vegetative cell" EXACT [PomBase:mah] synonym: "essential; elongated multinucleate vegetative cell" RELATED [PomBase:mah] synonym: "inviable elongated multinucleate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000133 ! elongated multinucleate vegetative cell is_a: FYPO:0001490 ! inviable elongated vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000061 ! multinucleate vegetative cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000061 ! multinucleate vegetative cell relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2012-08-30T14:27:16Z [Term] id: FYPO:0001494 name: inviable elongated multiseptate vegetative cell def: "A cell morphology phenotype in which a vegetative cell is inviable, longer than normal, and contains more than one septum." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "elongated inviable multiseptate cell during vegetative growth" EXACT [PomBase:mah] synonym: "elongated multiseptate inviable vegetative cell" EXACT [PomBase:mah] synonym: "essential; elongated multiseptate vegetative cell" RELATED [PomBase:mah] synonym: "inviable elongated multiseptate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000223 ! elongated multiseptate vegetative cell is_a: FYPO:0001490 ! inviable elongated vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000118 ! multiseptate vegetative cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000118 ! multiseptate vegetative cell relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2012-08-30T14:30:53Z [Term] id: FYPO:0001495 name: viable elongated multinucleate vegetative cell def: "A cell morphology phenotype in which a vegetative cell is viable, longer than normal, and contains more than one nucleus." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "elongated multinucleate viable cell during vegetative growth" EXACT [PomBase:mah] synonym: "elongated multinucleate viable vegetative cell" EXACT [PomBase:mah] synonym: "viable elongated multinucleate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000133 ! elongated multinucleate vegetative cell is_a: FYPO:0001492 ! viable elongated vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000061 ! multinucleate vegetative cell intersection_of: has_part FYPO:0001491 ! viable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000061 ! multinucleate vegetative cell relationship: has_part FYPO:0001491 ! viable vegetative cell created_by: midori creation_date: 2012-08-30T14:32:23Z [Term] id: FYPO:0001496 name: viable elongated multiseptate vegetative cell def: "A cell morphology phenotype in which a vegetative cell is viable, longer than normal, and contain more than one septum." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "elongated multiseptate viable vegetative cell" EXACT [PomBase:mah] synonym: "elongated viable multiseptate cell during vegetative growth" EXACT [PomBase:mah] synonym: "viable elongated multiseptate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000223 ! elongated multiseptate vegetative cell is_a: FYPO:0001492 ! viable elongated vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000118 ! multiseptate vegetative cell intersection_of: has_part FYPO:0001491 ! viable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000118 ! multiseptate vegetative cell relationship: has_part FYPO:0001491 ! viable vegetative cell created_by: midori creation_date: 2012-08-30T14:32:53Z [Term] id: FYPO:0001497 name: inviable elongated vegetative cell with mitotic cell cycle arrest in interphase def: "A cell morphology phenotype in which a vegetative cell is inviable and longer than normal, and progress through the mitotic cell cycle is arrested in interphase. The cell contains one nucleus and no septum." [PomBase:mah] comment: A population of cells with this phenotype usually shows a marginal increase in cell number before all cells die. Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "elongated inviable cell with mitotic cell cycle arrest in interphase during vegetative growth" EXACT [PomBase:mah] synonym: "elongated inviable vegetative cell with mitotic cell cycle arrest in interphase" EXACT [PomBase:mah] synonym: "essential; elongated vegetative cell with mitotic cell cycle arrest in interphase" RELATED [PomBase:mah] synonym: "inviable elongated mononucleate aseptate vegetative cell with cell cycle arrest in mitotic interphase" EXACT [PomBase:vw] synonym: "mitotic cell cycle arrest in interphase with elongated inviable cell" EXACT [PomBase:vw] synonym: "mitotic interphase arrested elongated inviable vegetative cell" EXACT [PomBase:mah] is_a: FYPO:0001490 ! inviable elongated vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000837 ! cell cycle arrest in mitotic interphase intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000837 ! cell cycle arrest in mitotic interphase relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2012-08-30T14:37:31Z [Term] id: FYPO:0001498 name: sensitive to cytochalasin B def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to cytochalasin B. Cells stop growing (and may die) at a concentration of cytochalasin B that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to cytochalasin B" EXACT [PomBase:mah] synonym: "sensitive to cytochalasin B during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to cytochalasin B during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:23527 ! cytochalasin B relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:23527 ! cytochalasin B created_by: midori creation_date: 2012-08-30T15:23:47Z [Term] id: FYPO:0001499 name: resistance to cytochalasin B def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of cytochalasin B than normal." [PomBase:mah] synonym: "resistance to cytochalasin B during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to cytochalasin B during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to cytochalasin B" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:23527 ! cytochalasin B relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:23527 ! cytochalasin B created_by: midori creation_date: 2012-08-30T15:24:42Z [Term] id: FYPO:0001500 name: normal growth on cytochalasin B def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing cytochalasin B." [PomBase:mah] synonym: "normal cell population growth in presence of cytochalasin B" EXACT [PomBase:mah] synonym: "normal cell population growth on cytochalasin B" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to cytochalasin B" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on cytochalasin B" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:23527 ! cytochalasin B relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:23527 ! cytochalasin B created_by: midori creation_date: 2012-08-30T15:25:41Z [Term] id: FYPO:0001501 name: sensitive to brefeldin A def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to brefeldin A. Cells stop growing (and may die) at a concentration of brefeldin A that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to brefeldin A" EXACT [PomBase:mah] synonym: "sensitive to BFA" EXACT [PomBase:mah] synonym: "sensitive to brefeldin A during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to brefeldin A during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:48080 ! brefeldin A relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:48080 ! brefeldin A created_by: midori creation_date: 2012-08-30T15:29:30Z [Term] id: FYPO:0001502 name: increased cellular trehalose level during cellular response to osmotic stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of trehalose measured in a cell is higher than normal when the cell is subject to osmotic stress." [PomBase:mah] synonym: "increased cellular trehalose level during cellular response to osmotic stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular trehalose level during vegetative growth and during cellular response to osmotic stress" EXACT [PomBase:mah] synonym: "increased cellular trehalose level in response to osmotic stress" EXACT [PomBase:al] synonym: "increased trehalose accumulation during cellular response to osmotic stress" RELATED [PomBase:mah] is_a: FYPO:0001444 ! increased cellular trehalose level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0071470 ! cellular response to osmotic stress intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:27082 ! trehalose relationship: exists_during GO:0071470 ! cellular response to osmotic stress relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:27082 ! trehalose created_by: midori creation_date: 2012-08-31T14:27:51Z [Term] id: FYPO:0001503 name: decreased alpha,alpha-trehalase activity during sporulation def: "A molecular function phenotype in which the observed rate of alpha,alpha-trehalase activity is lower than normal during sporulation." [PomBase:mah] synonym: "decreased neutral trehalase activity during sporulation" EXACT [PMID:9729425, PomBase:mah] synonym: "decreased trehalase activity during sporulation" BROAD [GO:0004555, GO:0015927] synonym: "reduced alpha,alpha-trehalase activity during sporulation" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0001479 ! abnormal alpha,alpha-trehalase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: during GO:0030437 ! ascospore formation intersection_of: inheres_in GO:0004555 ! alpha,alpha-trehalase activity relationship: during GO:0030437 ! ascospore formation relationship: inheres_in GO:0004555 ! alpha,alpha-trehalase activity created_by: midori creation_date: 2012-08-31T14:29:44Z [Term] id: FYPO:0001504 name: decreased cellular trehalose level during sporulation def: "A cell phenotype in which the amount of trehalose measured in a cell is lower than normal during sporulation." [PomBase:mah] synonym: "decreased cellular trehalose accumulation during sporulation" RELATED [PomBase:mah] synonym: "reduced cellular trehalose level during sporulation" EXACT [PomBase:mah] is_a: FYPO:0001447 ! decreased cellular trehalose level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0030437 ! ascospore formation intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:27082 ! trehalose relationship: exists_during GO:0030437 ! ascospore formation relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:27082 ! trehalose created_by: midori creation_date: 2012-08-31T14:31:44Z [Term] id: FYPO:0001505 name: increased cellular phosphatidylserine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of phosphatidylserine measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular phosphatidyl-L-serine level" EXACT [CHEBI:18303] synonym: "increased cellular phosphatidylserine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular phosphatidylserine level during vegetative growth" EXACT [PomBase:mah] synonym: "increased cellular PS level" EXACT [PomBase:mah] synonym: "increased phosphatidylserine accumulation" RELATED [PomBase:mah] is_a: FYPO:0001288 ! increased phospholipid level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:18303 ! phosphatidyl-L-serine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:18303 ! phosphatidyl-L-serine created_by: midori creation_date: 2012-08-31T14:45:54Z [Term] id: FYPO:0001506 name: normal cellular phosphatidylcholine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of phosphatidylcholine measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular PC level" EXACT [PomBase:mah] synonym: "normal cellular phosphatidylcholine accumulation" RELATED [PomBase:mah] synonym: "normal cellular phosphatidylcholine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular phosphatidylcholine level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:49183 ! phosphatidylcholine(1+) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:49183 ! phosphatidylcholine(1+) created_by: midori creation_date: 2012-08-31T14:48:33Z [Term] id: FYPO:0001507 name: normal cellular phosphatidylinositol level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of phosphatidylinositol measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular phosphatidylinositol accumulation" RELATED [PomBase:mah] synonym: "normal cellular phosphatidylinositol level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular phosphatidylinositol level during vegetative growth" EXACT [PomBase:mah] synonym: "normal cellular PI level" EXACT [CHEBI:28874, PomBase:mah] is_a: FYPO:0001543 ! normal cellular phosphorus level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:28874 ! phosphatidylinositol relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:28874 ! phosphatidylinositol created_by: midori creation_date: 2012-08-31T14:49:23Z [Term] id: FYPO:0001508 name: abolished protein localization to chromatin during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to chromatin is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to chromatin during vegetative growth" EXACT [PomBase:mah] synonym: "abolished protein localization to chromatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein localization to chromatin during vegetative growth abolished" EXACT [PomBase:mah] is_a: FYPO:0000452 ! abnormal protein localization to chromatin during vegetative growth is_a: FYPO:0001678 ! abolished protein localization to chromatin is_a: FYPO:0002841 ! abolished protein localization to chromosome intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0071168 ! protein localization to chromatin relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0071168 ! protein localization to chromatin created_by: midori creation_date: 2012-09-04T17:02:28Z [Term] id: FYPO:0001509 name: normal protein localization to chromatin def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to chromatin is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to chromatin" EXACT [PomBase:mah] synonym: "normal protein localization to chromatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to chromatin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000644 ! normal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071168 ! protein localization to chromatin intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071168 ! protein localization to chromatin relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-09-04T17:04:49Z [Term] id: FYPO:0001510 name: viable vegetative cell, abnormal cell shape, normal cell size def: "A cell phenotype in which a cell is viable, cell shape is altered, and cell size remains normal, in the vegetative growth phase of the life cycle." [PomBase:mah, PomBase:vw] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "viable lumpy cell" RELATED [PomBase:vw] synonym: "viable vegetative cell with abnormal cell shape and normal cell size" RELATED [PomBase:mah] synonym: "viable vegetative cell, abnormal cell shape, normal cell size during mitotic cell cycle" RELATED [PomBase:mah] synonym: "viable, abnormal cell shape, normal cell size during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001121 ! vegetative cell, abnormal cell shape, normal cell size is_a: FYPO:0002197 ! viable vegetative cell with abnormal cell shape intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0001124 ! normal vegetative cell size intersection_of: has_part FYPO:0001126 ! abnormal cell shape intersection_of: has_part FYPO:0001491 ! viable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0001124 ! normal vegetative cell size relationship: has_part FYPO:0001126 ! abnormal cell shape relationship: has_part FYPO:0001491 ! viable vegetative cell created_by: midori creation_date: 2012-09-13T10:47:20Z [Term] id: FYPO:0001511 name: inviable vegetative cell, abnormal cell shape, normal cell size def: "A cell phenotype in which a cell is inviable, cell shape is altered, and cell size remains normal, in the vegetative growth phase of the life cycle." [PomBase:mah, PomBase:vw] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "inviable lumpy cell" RELATED [PomBase:vw] synonym: "inviable vegetative cell with abnormal cell shape and normal cell size" RELATED [PomBase:mah] synonym: "inviable vegetative cell, abnormal cell shape, normal cell size during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable, abnormal cell shape, normal cell size during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001121 ! vegetative cell, abnormal cell shape, normal cell size is_a: FYPO:0002451 ! inviable vegetative cell with abnormal cell shape intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0001124 ! normal vegetative cell size intersection_of: has_part FYPO:0001126 ! abnormal cell shape intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0001124 ! normal vegetative cell size relationship: has_part FYPO:0001126 ! abnormal cell shape relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2012-09-13T10:52:33Z [Term] id: FYPO:0001512 name: branched, elongated cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is branched and longer than normal." [PomBase:mah] comment: These cells often form a branch at a non-right angle to the long axis of the mother cell. synonym: "branched, elongated cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "branched, elongated cell during vegetative growth" EXACT [PomBase:mah] synonym: "branched, long cell" EXACT [PomBase:vw] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000015 ! branched vegetative cell intersection_of: has_part FYPO:0000017 ! elongated cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000015 ! branched vegetative cell relationship: has_part FYPO:0000017 ! elongated cell created_by: midori creation_date: 2012-09-13T10:58:38Z [Term] id: FYPO:0001513 name: normal mitotic sister chromatid segregation def: "A cellular process phenotype in which mitotic sister chromatid segregation is normal (i.e. indistinguishable from wild type). Mitotic sister chromatid segregation is the entire process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle." [GO:0000070, PomBase:mah] synonym: "normal mitotic chromosome segregation" EXACT [PomBase:mah] synonym: "normal mitotic sister chromatid segregation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002741 ! normal mitotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000070 ! mitotic sister chromatid segregation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000070 ! mitotic sister chromatid segregation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-09-13T11:23:11Z [Term] id: FYPO:0001514 name: decreased protein localization to nucleus during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleus is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to nucleus during vegetative growth" EXACT [GO:0034504, PomBase:mah] synonym: "decreased protein localization to nucleus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "reduced protein localization to nucleus during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001129 ! abnormal protein localization to nucleus during vegetative growth is_a: FYPO:0004455 ! decreased protein localization to nucleus intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034504 ! protein localization to nucleus relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034504 ! protein localization to nucleus created_by: midori creation_date: 2012-09-13T11:39:44Z [Term] id: FYPO:0001515 name: abnormal telomere tethering at nuclear periphery def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which telomere tethering at the nuclear periphery is abnormal." [PomBase:mah] synonym: "abnormal telomere anchoring at nuclear periphery" EXACT [PomBase:vw] synonym: "abnormal telomere tethering at nuclear periphery during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal telomere tethering at nuclear periphery during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001337 ! localization phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0034398 ! telomere tethering at nuclear periphery intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0034398 ! telomere tethering at nuclear periphery relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-09-13T11:46:25Z [Term] id: FYPO:0001516 name: resistance to mercury def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of mercury ions than normal." [PomBase:mah] synonym: "resistance to mercury during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to mercury during vegetative growth" EXACT [PomBase:mah] synonym: "resistance to mercury ion" EXACT [PomBase:mah] synonym: "resistant to mercury" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:25197 ! mercury cation relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:25197 ! mercury cation created_by: midori creation_date: 2012-09-13T13:16:13Z [Term] id: FYPO:0001517 name: resistance to aluminium def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of aluminium ions than normal." [PomBase:mah] synonym: "resistance to aluminium cation" EXACT [CHEBI:63062] synonym: "resistance to aluminium during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to aluminium during vegetative growth" EXACT [PomBase:mah] synonym: "resistance to aluminum" EXACT [PomBase:mah] synonym: "resistant to aluminium" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:63062 ! aluminium cation relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:63062 ! aluminium cation created_by: midori creation_date: 2012-09-13T13:22:53Z [Term] id: FYPO:0001518 name: resistance to diethyl maleate def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of diethyl maleate than normal." [PomBase:mah] comment: Note that diethyl maleate should not be written without a space, as diethylmaleate is a different compound. synonym: "resistance to DEM" EXACT [PomBase:al] synonym: "resistance to diethyl maleate during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to diethyl maleate during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to diethyl maleate" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:68508 ! diethyl maleate relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:68508 ! diethyl maleate created_by: midori creation_date: 2012-09-13T13:41:57Z [Term] id: FYPO:0001519 name: abnormal gamma-glutamyltransferase activity def: "A molecular function phenotype in which the observed rate of gamma-glutamyltransferase activity is abnormal." [PomBase:mah] synonym: "abnormal gamma-glutamyl transpeptidase activity" EXACT [GO:0003840, PomBase:mah] synonym: "abnormal GGT activity" BROAD [PomBase:al, PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0003840 ! gamma-glutamyltransferase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0003840 ! gamma-glutamyltransferase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-09-13T13:53:10Z [Term] id: FYPO:0001520 name: increased gamma-glutamyltransferase activity def: "A molecular function phenotype in which the observed rate of gamma-glutamyltransferase activity is increased." [PomBase:mah] synonym: "increased gamma-glutamyl transpeptidase activity" EXACT [GO:0003840, PomBase:mah] synonym: "increased GGT activity" BROAD [PomBase:al, PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0001519 ! abnormal gamma-glutamyltransferase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0003840 ! gamma-glutamyltransferase activity relationship: inheres_in GO:0003840 ! gamma-glutamyltransferase activity created_by: midori creation_date: 2012-09-13T13:53:17Z [Term] id: FYPO:0001521 name: increased cellular glutathione level during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of glutathione (GSH) measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular glutathione level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular GSH level during vegetative growth" EXACT [CHEBI:16856, PomBase:al] synonym: "increased cellular L-gamma-glutamyl-L-cysteinylglycine level during vegetative growth" EXACT [CHEBI:16856] synonym: "increased cellular reduced glutathione level during vegetative growth" EXACT [CHEBI:16856, PomBase:al] synonym: "increased glutathione accumulation during vegetative growth" RELATED [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:16856 ! glutathione relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:16856 ! glutathione created_by: midori creation_date: 2012-09-13T14:02:16Z [Term] id: FYPO:0001522 name: normal growth on caffeine def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing caffeine." [PomBase:mah] synonym: "normal cell population growth in presence of caffeine" EXACT [PomBase:mah] synonym: "normal cell population growth on caffeine" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to caffeine" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on caffeine" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:27732 ! caffeine relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:27732 ! caffeine created_by: midori creation_date: 2012-09-13T14:06:29Z [Term] id: FYPO:0001523 name: normal growth on leptomycin B def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing leptomycin B." [PomBase:mah] synonym: "normal cell population growth in presence of leptomycin B" EXACT [PomBase:mah] synonym: "normal cell population growth on leptomycin B" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to leptomycin B" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on leptomycin B" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:52646 ! leptomycin B relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:52646 ! leptomycin B created_by: midori creation_date: 2012-09-13T14:09:56Z [Term] id: FYPO:0001524 name: resistance to L-thialysine def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of L-thialysine than normal." [PomBase:mah] synonym: "resistance to L-thialysine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to L-thialysine during vegetative growth" EXACT [PomBase:mah] synonym: "resistance to thialysine" BROAD [PomBase:mah] synonym: "resistant to L-thialysine" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:497734 ! L-thialysine relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:497734 ! L-thialysine created_by: midori creation_date: 2012-09-13T14:36:42Z [Term] id: FYPO:0001525 name: sensitive to L-thialysine def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to L-thialysine. Cells stop growing (and may die) at a concentration of L-thialysine that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to L-thialysine" EXACT [PomBase:mah] synonym: "sensitive to L-thialysine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to L-thialysine during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to thialysine" BROAD [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:497734 ! L-thialysine relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:497734 ! L-thialysine created_by: midori creation_date: 2012-09-13T14:43:00Z [Term] id: FYPO:0001526 name: normal growth on L-thialysine def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing L-thialysine." [PomBase:mah] synonym: "normal cell population growth in presence of L-thialysine" EXACT [PomBase:mah] synonym: "normal cell population growth on L-thialysine" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cell population growth on thialysine" BROAD [PomBase:mah] synonym: "normal cellular response to L-thialysine" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on L-thialysine" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:497734 ! L-thialysine relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:497734 ! L-thialysine created_by: midori creation_date: 2012-09-13T14:46:44Z [Term] id: FYPO:0001527 name: normal GTP binding def: "A molecular function phenotype in which occurrence of GTP binding by a gene product (usually a protein) in a mutant is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000706 ! normal molecular function is_a: FYPO:0001092 ! binding phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0005525 ! GTP binding intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0005525 ! GTP binding relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-09-13T14:53:26Z [Term] id: FYPO:0001528 name: abnormal GTP binding def: "A molecular function phenotype in which occurrence of GTP binding by a gene product (usually a protein) in a mutant is abnormal. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] comment: This term can mean that the mutated gene product itself binds GTP differently from wild type, or that a mutation in one gene affects GTP binding by a second gene product. When using this term, it is therefore recommended to note the specific protein(s) affected. is_a: FYPO:0000707 ! abnormal molecular function is_a: FYPO:0001092 ! binding phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0005525 ! GTP binding intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0005525 ! GTP binding relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-09-13T14:54:29Z [Term] id: FYPO:0001529 name: decreased GTP binding def: "A molecular function phenotype in which occurrence of GTP binding by a gene product (usually a protein) in a mutant is decreased. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] comment: This term can mean that the mutated gene product itself binds GTP less than wild type, or that a mutation in one gene decreases GTP binding by a second gene product. When using this term, it is therefore recommended to note the specific protein(s) affected. synonym: "reduced GTP binding" EXACT [PomBase:mah] is_a: FYPO:0001528 ! abnormal GTP binding is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0005525 ! GTP binding relationship: inheres_in GO:0005525 ! GTP binding created_by: midori creation_date: 2012-09-13T14:55:25Z [Term] id: FYPO:0001530 name: abnormal GTPase activity def: "A molecular function phenotype in which the observed rate of GTPase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0003924 ! GTPase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0003924 ! GTPase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-09-13T15:01:53Z [Term] id: FYPO:0001531 name: decreased GTPase activity def: "A molecular function phenotype in which the observed rate of GTPase activity is decreased." [PomBase:mah] synonym: "reduced GTPase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0001530 ! abnormal GTPase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0003924 ! GTPase activity relationship: inheres_in GO:0003924 ! GTPase activity created_by: midori creation_date: 2012-09-13T15:02:01Z [Term] id: FYPO:0001532 name: normal duration of mitotic S phase def: "A cell cycle phenotype in the duration of S phase of the mitotic cell cycle is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0003246 ! normal mitotic S phase progression is_a: PATO:0001309 ! duration intersection_of: PATO:0001309 ! duration intersection_of: inheres_in GO:0000084 ! mitotic S phase intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0000084 ! mitotic S phase relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-09-13T15:28:30Z [Term] id: FYPO:0001533 name: sensitive to zinc starvation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to zinc starvation." [PomBase:mah] synonym: "hypersensitive to zinc starvation" EXACT [PomBase:mah] synonym: "sensitive to zinc depletion" EXACT [PomBase:vw] synonym: "sensitive to zinc deprivation" EXACT [PomBase:vw] synonym: "sensitive to zinc ion starvation" EXACT [PomBase:mah] synonym: "sensitive to zinc starvation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to zinc starvation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000304 ! sensitive to stress during vegetative growth created_by: midori creation_date: 2012-09-13T15:35:17Z [Term] id: FYPO:0001534 name: decreased cellular zinc level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of zinc ion measured in a cell is lower than normal." [PomBase:mah] synonym: "decreased cellular zinc ion level" EXACT [PomBase:mah] synonym: "decreased cellular zinc level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular zinc level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased zinc accumulation" RELATED [PomBase:al] synonym: "reduced cellular zinc level" EXACT [PomBase:mah] is_a: FYPO:0001329 ! decreased level of substance in cell during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:27365 ! zinc ion relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:27365 ! zinc ion created_by: midori creation_date: 2012-09-13T15:43:51Z [Term] id: FYPO:0001535 name: normal cellular zinc level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of zinc ion measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular zinc accumulation" RELATED [PomBase:mah] synonym: "normal cellular zinc ion level" EXACT [PomBase:mah] synonym: "normal cellular zinc level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular zinc level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:27365 ! zinc ion relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:27365 ! zinc ion created_by: midori creation_date: 2012-09-13T15:48:08Z [Term] id: FYPO:0001536 name: normal cellular copper level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of copper ion measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular copper accumulation" RELATED [PomBase:mah] synonym: "normal cellular copper ion level" EXACT [PomBase:mah] synonym: "normal cellular copper level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular copper level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:23378 ! copper cation relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:23378 ! copper cation created_by: midori creation_date: 2012-09-13T16:07:14Z [Term] id: FYPO:0001537 name: normal cellular iron level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of iron ion measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular iron accumulation" RELATED [PomBase:mah] synonym: "normal cellular iron ion level" EXACT [PomBase:mah] synonym: "normal cellular iron level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular iron level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:24875 ! iron cation relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:24875 ! iron cation created_by: midori creation_date: 2012-09-13T16:07:47Z [Term] id: FYPO:0001538 name: normal cellular potassium level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of potassium ion measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular potassium accumulation" RELATED [PomBase:mah] synonym: "normal cellular potassium ion level" EXACT [PomBase:mah] synonym: "normal cellular potassium level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular potassium level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:29103 ! potassium(1+) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:29103 ! potassium(1+) created_by: midori creation_date: 2012-09-13T16:08:23Z [Term] id: FYPO:0001539 name: normal cellular magnesium level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of magnesium ion measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular magnesium accumulation" RELATED [PomBase:mah] synonym: "normal cellular magnesium ion level" EXACT [PomBase:mah] synonym: "normal cellular magnesium level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular magnesium level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:18420 ! magnesium(2+) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:18420 ! magnesium(2+) created_by: midori creation_date: 2012-09-13T16:14:33Z [Term] id: FYPO:0001540 name: normal cellular manganese level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of manganese ion measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular manganese accumulation" RELATED [PomBase:mah] synonym: "normal cellular manganese ion level" EXACT [PomBase:mah] synonym: "normal cellular manganese level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular manganese level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:25155 ! manganese cation relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:25155 ! manganese cation created_by: midori creation_date: 2012-09-13T16:08:54Z [Term] id: FYPO:0001541 name: normal cellular molybdenum level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of molybdenum ion measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular molybdenum accumulation" RELATED [PomBase:mah] synonym: "normal cellular molybdenum ion level" EXACT [PomBase:mah] synonym: "normal cellular molybdenum level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular molybdenum level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:37239 ! molybdenum cation relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:37239 ! molybdenum cation created_by: midori creation_date: 2012-09-13T16:09:45Z [Term] id: FYPO:0001542 name: normal cellular nickel level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of nickel ion measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular nickel accumulation" RELATED [PomBase:mah] synonym: "normal cellular nickel ion level" EXACT [PomBase:mah] synonym: "normal cellular nickel level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular nickel level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:25516 ! nickel cation relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:25516 ! nickel cation created_by: midori creation_date: 2012-09-13T16:10:13Z [Term] id: FYPO:0001543 name: normal cellular phosphorus level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of a phosphorus-containing substance measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular phosphorus accumulation" RELATED [PomBase:mah] synonym: "normal cellular phosphorus level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular phosphorus level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:26082 ! phosphorus molecular entity relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:26082 ! phosphorus molecular entity created_by: midori creation_date: 2012-09-13T16:11:42Z [Term] id: FYPO:0001544 name: normal cellular sulfur level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of sulfur measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular sulfur accumulation" RELATED [PomBase:mah] synonym: "normal cellular sulfur level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular sulfur level during vegetative growth" EXACT [PomBase:mah] synonym: "normal cellular sulphur level" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:26835 ! sulfur molecular entity relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:26835 ! sulfur molecular entity created_by: midori creation_date: 2012-09-13T16:12:10Z [Term] id: FYPO:0001545 name: normal growth on L-canavanine def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing L-canavanine." [PomBase:mah] synonym: "normal cell population growth in presence of L-canavanine" EXACT [PomBase:mah] synonym: "normal cell population growth on canavanine" BROAD [PomBase:mah] synonym: "normal cell population growth on L-canavanine" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to L-canavanine" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on L-canavanine" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:609827 ! L-canavanine relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:609827 ! L-canavanine created_by: midori creation_date: 2012-09-14T14:23:13Z [Term] id: FYPO:0001546 name: decreased RNA level during cellular response to zinc ion def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to zinc ion is lower than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased mRNA level during cellular response to zinc ion" NARROW [PomBase:mah] synonym: "decreased RNA accumulation during cellular response to zinc ion" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to zinc" EXACT [GO:0071456] synonym: "decreased RNA level during cellular response to zinc ion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to zinc ion during vegetative growth" EXACT [PomBase:mah] synonym: "decreased transcript level during cellular response to zinc ion" EXACT [PomBase:vw] synonym: "reduced RNA level during cellular response to zinc ion" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0071294 ! cellular response to zinc ion intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0071294 ! cellular response to zinc ion relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2012-09-14T14:26:22Z [Term] id: FYPO:0001547 name: increased RNA level during cellular response to zinc ion starvation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to zinc ion starvation is higher than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased mRNA level during cellular response to zinc ion starvation" NARROW [PomBase:mah] synonym: "increased RNA accumulation during cellular response to zinc ion starvation" RELATED [PomBase:mah] synonym: "increased RNA level during cellular response to zinc ion depletion" EXACT [PomBase:vw] synonym: "increased RNA level during cellular response to zinc ion deprivation" EXACT [PomBase:vw] synonym: "increased RNA level during cellular response to zinc ion starvation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased RNA level during cellular response to zinc ion starvation during vegetative growth" EXACT [PomBase:mah] synonym: "increased RNA level during cellular response to zinc starvation" EXACT [PomBase:mah] synonym: "increased transcript level during cellular response to zinc ion starvation" EXACT [PomBase:vw] is_a: FYPO:0000825 ! increased RNA level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0034224 ! cellular response to zinc ion starvation intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0034224 ! cellular response to zinc ion starvation relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2012-09-14T14:28:30Z [Term] id: FYPO:0001548 name: altered protein level during cellular response to hydrogen peroxide def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell differs from normal during a cellular response to hydrogen peroxide. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein level during cellular response to hydrogen peroxide" EXACT [PomBase:mah] synonym: "altered cellular protein level during cellular response to hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] synonym: "altered protein level during cellular response to H2O2" EXACT [PomBase:mah] synonym: "altered protein level during cellular response to hydrogen peroxide during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001325 ! altered protein level during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0070301 ! cellular response to hydrogen peroxide intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0070301 ! cellular response to hydrogen peroxide relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2012-09-14T14:32:40Z [Term] id: FYPO:0001549 name: altered protein level during cellular response to hypoxia def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell differs from normal during a cellular response to hypoxia. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein level during cellular response to hypoxia" EXACT [PomBase:mah] synonym: "altered cellular protein level during cellular response to hypoxia during vegetative growth" EXACT [PomBase:mah] synonym: "altered protein level during cellular response to hypoxia during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001325 ! altered protein level during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0071456 ! cellular response to hypoxia intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0071456 ! cellular response to hypoxia relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2012-09-14T14:34:37Z [Term] id: FYPO:0001550 name: altered protein level during cellular response to zinc ion def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell differs from normal during a cellular response to zinc ions. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein level during cellular response to zinc ion" EXACT [PomBase:mah] synonym: "altered cellular protein level during cellular response to zinc ion during vegetative growth" EXACT [PomBase:mah] synonym: "altered protein level during cellular response to zinc" EXACT [PomBase:mah] synonym: "altered protein level during cellular response to zinc ion during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001325 ! altered protein level during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0071294 ! cellular response to zinc ion intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0071294 ! cellular response to zinc ion relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2012-09-14T14:36:13Z [Term] id: FYPO:0001551 name: increased protein level during cellular response to zinc ion starvation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during a cellular response to zinc ion starvation is higher than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein accumulation during cellular response to zinc ion starvation" RELATED [PomBase:mah] synonym: "increased protein level during cellular response to zinc ion depletion" EXACT [PomBase:vw] synonym: "increased protein level during cellular response to zinc ion deprivation" EXACT [PomBase:vw] synonym: "increased protein level during cellular response to zinc ion starvation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein level during cellular response to zinc ion starvation during vegetative growth" EXACT [PomBase:mah] synonym: "increased protein level during cellular response to zinc starvation" EXACT [GO:0071453] is_a: FYPO:0001327 ! increased protein level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0034224 ! cellular response to zinc ion starvation intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0034224 ! cellular response to zinc ion starvation relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2012-09-14T14:37:37Z [Term] id: FYPO:0001552 name: increased cellular zinc level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of zinc ion measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular zinc ion level" EXACT [PomBase:mah] synonym: "increased cellular zinc level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular zinc level during vegetative growth" EXACT [PomBase:mah] synonym: "increased zinc accumulation" RELATED [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:27365 ! zinc ion relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:27365 ! zinc ion created_by: midori creation_date: 2012-09-14T14:42:05Z [Term] id: FYPO:0001553 name: abnormal RNA processing def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which RNA processing is abnormal. RNA processing is the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GO:0006396, PomBase:mah] synonym: "abnormal RNA processing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal RNA processing during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000142 ! gene expression phenotype is_a: FYPO:0000294 ! RNA metabolism phenotype is_a: FYPO:0001363 ! abnormal metabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006396 ! RNA processing intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006396 ! RNA processing relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-09-14T15:07:19Z [Term] id: FYPO:0001554 name: abnormal tRNA processing def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which tRNA processing is abnormal. tRNA processing is the conversion a primary tRNA transcript into a mature tRNA molecules." [GO:0008033, PomBase:mah] synonym: "abnormal tRNA processing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal tRNA processing during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001553 ! abnormal RNA processing intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0008033 ! tRNA processing intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0008033 ! tRNA processing relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-09-14T15:10:20Z [Term] id: FYPO:0001555 name: formation of abnormal tRNA processing intermediates def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the intermediate RNAs formed during tRNA processing differ from wild type in size." [PomBase:al, PomBase:mah] comment: Note that the mature tRNA may be of normal or abnormal size. synonym: "abnormal tRNA maturation intermediates" EXACT [PomBase:al] synonym: "formation of abnormal tRNA processing intermediates during mitotic cell cycle" RELATED [PomBase:mah] synonym: "formation of abnormal tRNA processing intermediates during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001554 ! abnormal tRNA processing created_by: midori creation_date: 2012-09-14T15:12:24Z [Term] id: FYPO:0001556 name: excess nuclear envelope present def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells contain more nuclear envelope than normal. Excess nuclear envelopes may take the form of intranuclear membrane stacks or small cytoplasmic spheres that are attached to the nucleus, have double lipid bilayer membranes, and may structures resembling nuclear pores." [PMID:22156749, PomBase:mah] synonym: "excess nuclear envelope present during mitotic cell cycle" RELATED [PomBase:mah] synonym: "excess nuclear envelope present during vegetative growth" EXACT [PomBase:mah] synonym: "increased nuclear envelope proliferation" RELATED [PMID:22156749, PomBase:vw] synonym: "nuclear envelope present in greater amount" EXACT [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: FYPO:0002403 ! abnormal nucleus is_a: PATO:0002002 ! has extra parts of type intersection_of: PATO:0002002 ! has extra parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0005635 ! nuclear envelope relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0005635 ! nuclear envelope created_by: midori creation_date: 2012-09-14T15:22:32Z [Term] id: FYPO:0001557 name: resistance to ethionine def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of ethionine than normal." [PomBase:mah] comment: Note that a racemic mixture of D and L enantiomers of ethionine is usually used to test sensitivity or resistance. synonym: "resistance to DL-ethionine" RELATED [PomBase:mah] synonym: "resistance to ethionine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to ethionine during vegetative growth" EXACT [PomBase:mah] synonym: "resistance to S-ethylhomocysteine" EXACT [CHEBI:68662, PomBase:mah] synonym: "resistant to ethionine" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:68662 ! S-ethylhomocysteine relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:68662 ! S-ethylhomocysteine created_by: midori creation_date: 2012-09-14T16:15:57Z [Term] id: FYPO:0001558 name: decreased methionine import def: "A cellular process phenotype in which the import of methionine into the cell occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased L-methionine import" EXACT [PomBase:mah] synonym: "decreased methionine import into cell" EXACT [PomBase:al] synonym: "decreased methionine transport into cell" EXACT [PomBase:al] synonym: "decreased methionine uptake" EXACT [PomBase:mah] synonym: "reduced methionine import" EXACT [PomBase:mah] synonym: "reduced methionine uptake" EXACT [PomBase:vw] is_a: FYPO:0001058 ! decreased amino acid import intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:1903813 ! L-methionine import into cell relationship: inheres_in GO:1903813 ! L-methionine import into cell created_by: midori creation_date: 2012-09-14T16:32:14Z [Term] id: FYPO:0001559 name: normal methionine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which methionine import into the cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal L-methionine import" EXACT [PomBase:mah] synonym: "normal methionine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal methionine import during vegetative growth" EXACT [PomBase:mah] synonym: "normal methionine import into cell" EXACT [PomBase:al] synonym: "normal methionine uptake" EXACT [PomBase:mah] is_a: FYPO:0001071 ! normal transport is_a: FYPO:0001336 ! transport phenotype during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903813 ! L-methionine import into cell intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903813 ! L-methionine import into cell relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-09-14T16:34:42Z [Term] id: FYPO:0001560 name: decreased cellular threonine level alt_id: FYPO:0001614 def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-threonine measured in a cell is lower than normal." [PomBase:mah] synonym: "decreased cellular L-threonine level" EXACT [PomBase:mah] synonym: "decreased cellular threonine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular threonine level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased level of threonine in cell" EXACT [PomBase:mah] synonym: "decreased threonine accumulation" RELATED [PomBase:al] synonym: "reduced cellular threonine level" EXACT [PomBase:mah] synonym: "reduced level of threonine in cell" EXACT [PomBase:mah] is_a: FYPO:0003985 ! decreased cellular amino acid level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:16857 ! L-threonine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:16857 ! L-threonine created_by: midori creation_date: 2012-09-14T16:44:29Z [Term] id: FYPO:0001561 name: decreased cellular citrulline level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-citrulline measured in a cell is lower than normal." [PomBase:mah] synonym: "decreased cellular citrulline level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular citrulline level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased cellular L-citrulline level" EXACT [PomBase:mah] synonym: "decreased citrulline accumulation" RELATED [PomBase:al] synonym: "reduced cellular citrulline level" EXACT [PomBase:mah] is_a: FYPO:0003985 ! decreased cellular amino acid level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:16349 ! L-citrulline relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:16349 ! L-citrulline created_by: midori creation_date: 2012-09-14T16:45:19Z [Term] id: FYPO:0001562 name: decreased cellular histidine level alt_id: FYPO:0001620 def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-histidine measured in a cell is lower than normal." [PomBase:mah] synonym: "decreased cellular histidine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular histidine level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased cellular L-histidine level" EXACT [PomBase:mah] synonym: "decreased histidine accumulation" RELATED [PomBase:al] synonym: "reduced cellular histidine level" EXACT [PomBase:mah] is_a: FYPO:0003985 ! decreased cellular amino acid level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:15971 ! L-histidine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:15971 ! L-histidine created_by: midori creation_date: 2012-09-14T16:46:05Z [Term] id: FYPO:0001563 name: decreased cellular glutamate level alt_id: FYPO:0001615 def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-glutamate measured in a cell is lower than normal." [PomBase:mah] synonym: "decreased cellular glutamate level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular glutamate level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased cellular glutamic acid level" RELATED [PomBase:mah] synonym: "decreased cellular L-glutamate level" EXACT [PomBase:mah] synonym: "decreased glutamate accumulation" RELATED [PomBase:al] synonym: "reduced cellular glutamate level" EXACT [PomBase:mah] is_a: FYPO:0001329 ! decreased level of substance in cell during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:29989 ! D-glutamate(2-) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:29989 ! D-glutamate(2-) created_by: midori creation_date: 2012-09-14T16:46:41Z [Term] id: FYPO:0001564 name: decreased cellular ornithine level alt_id: FYPO:0001618 def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-ornithine measured in a cell is lower than normal." [PomBase:mah] synonym: "decreased cellular L-ornithine level" EXACT [PomBase:mah] synonym: "decreased cellular ornithine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular ornithine level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased ornithine accumulation" RELATED [PomBase:al] synonym: "reduced cellular ornithine level" EXACT [PomBase:mah] is_a: FYPO:0003985 ! decreased cellular amino acid level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:15729 ! L-ornithine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:15729 ! L-ornithine created_by: midori creation_date: 2012-09-14T16:47:41Z [Term] id: FYPO:0001565 name: increased cellular threonine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-threonine measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular L-threonine level" EXACT [CHEBI:16856, PomBase:al] synonym: "increased cellular threonine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular threonine level during vegetative growth" EXACT [PomBase:mah] synonym: "increased threonine accumulation" RELATED [PomBase:mah] is_a: FYPO:0003986 ! increased cellular amino acid level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:16857 ! L-threonine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:16857 ! L-threonine created_by: midori creation_date: 2012-09-14T16:48:22Z [Term] id: FYPO:0001566 name: increased cellular citrulline level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-citrulline measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular citrulline level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular citrulline level during vegetative growth" EXACT [PomBase:mah] synonym: "increased cellular L-citrulline level" EXACT [CHEBI:16856, PomBase:al] synonym: "increased citrulline accumulation" RELATED [PomBase:mah] is_a: FYPO:0003986 ! increased cellular amino acid level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:16349 ! L-citrulline relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:16349 ! L-citrulline created_by: midori creation_date: 2012-09-14T16:49:05Z [Term] id: FYPO:0001567 name: increased cellular histidine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-histidine measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular histidine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular histidine level during vegetative growth" EXACT [PomBase:mah] synonym: "increased cellular L-histidine level" EXACT [CHEBI:16856, PomBase:al] synonym: "increased histidine accumulation" RELATED [PomBase:mah] is_a: FYPO:0003986 ! increased cellular amino acid level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:15971 ! L-histidine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:15971 ! L-histidine created_by: midori creation_date: 2012-09-14T16:49:35Z [Term] id: FYPO:0001568 name: increased cellular glutamate level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-glutamate measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular glutamate level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular glutamate level during vegetative growth" EXACT [PomBase:mah] synonym: "increased cellular L-glutamate level" EXACT [CHEBI:16856, PomBase:al] synonym: "increased glutamate accumulation" RELATED [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:29989 ! D-glutamate(2-) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:29989 ! D-glutamate(2-) created_by: midori creation_date: 2012-09-14T16:50:25Z [Term] id: FYPO:0001569 name: increased cellular ornithine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-ornithine measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular L-ornithine level" EXACT [CHEBI:16856, PomBase:al] synonym: "increased cellular ornithine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular ornithine level during vegetative growth" EXACT [PomBase:mah] synonym: "increased ornithine accumulation" RELATED [PomBase:mah] is_a: FYPO:0003986 ! increased cellular amino acid level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:15729 ! L-ornithine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:15729 ! L-ornithine created_by: midori creation_date: 2012-09-14T16:51:00Z [Term] id: FYPO:0001570 name: decreased cellular glutathione level during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of glutathione (GSH) measured in a cell is lower than normal." [PomBase:mah] synonym: "decreased cellular glutathione level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular GSH level during vegetative growth" EXACT [CHEBI:16856, PomBase:al] synonym: "decreased cellular L-gamma-glutamyl-L-cysteinylglycine level during vegetative growth" EXACT [CHEBI:16856] synonym: "decreased cellular reduced glutathione level during vegetative growth" EXACT [CHEBI:16856, PomBase:al] synonym: "decreased glutathione accumulation during vegetative growth" RELATED [PomBase:mah] synonym: "reduced cellular glutathione level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001329 ! decreased level of substance in cell during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:16856 ! glutathione relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:16856 ! glutathione created_by: midori creation_date: 2012-09-14T16:51:27Z [Term] id: FYPO:0001571 name: increased protein binding def: "A molecular function phenotype in which the binding of one protein to another occurs to a greater extent than normal. The relevant proteins may include the one encoded by the mutated gene, or may both be encoded by different genes." [PomBase:mah] comment: This term can be used for any protein-protein interaction that is affected by a mutation, whether or not the mutated gene product is one of the interacting proteins. We recommend noting which proteins were used in the assay when annotating to this term. synonym: "increased protein-protein interaction" EXACT [PomBase:mah] is_a: FYPO:0000704 ! abnormal protein binding is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0005515 ! protein binding relationship: inheres_in GO:0005515 ! protein binding created_by: midori creation_date: 2012-09-20T13:22:04Z [Term] id: FYPO:0001572 name: abolished cell population growth on methionine nitrogen source def: "A vegetative cell population growth phenotype in which a cell population does not grow in a medium containing L-methionine as the nitrogen source." [PomBase:mah] comment: Use this term for a population of cells that does not grow with methionine as the nitrogen source, but does grow using a different nitrogen source (a cell population that does not grow on any media would be considered inviable). Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "abolished growth on methionine nitrogen source" BROAD [PomBase:mah] synonym: "abolished methionine utilization" RELATED [PomBase:mah, PomBase:vw] synonym: "abolished vegetative cell population growth on methionine nitrogen source" EXACT [PomBase:mah] synonym: "cell population growth on methionine nitrogen source abolished" EXACT [PomBase:mah] is_a: FYPO:0001575 ! abolished vegetative cell population growth created_by: midori creation_date: 2012-09-20T13:55:30Z [Term] id: FYPO:0001573 name: increased RNA level during cellular response to rapamycin def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to rapamycin is higher than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased mRNA level during cellular response to rapamycin" NARROW [PomBase:mah] synonym: "increased RNA accumulation during cellular response to rapamycin" RELATED [PomBase:mah] synonym: "increased RNA level during cellular response to rapamycin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased RNA level during cellular response to rapamycin during vegetative growth" EXACT [PomBase:mah] synonym: "increased transcript level during cellular response to rapamycin" EXACT [PomBase:vw] is_a: FYPO:0000825 ! increased RNA level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: exists_during GO:0072752 ! cellular response to rapamycin intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: exists_during GO:0072752 ! cellular response to rapamycin relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2012-09-20T14:11:44Z [Term] id: FYPO:0001574 name: abnormal bipolar mitotic spindle def: "A physical cellular phenotype in which the mitotic spindle has two poles but is otherwise structurally abnormal." [PomBase:mah] is_a: FYPO:0000338 ! abnormal mitotic spindle created_by: midori creation_date: 2012-09-20T14:36:56Z [Term] id: FYPO:0001575 name: abolished vegetative cell population growth def: "A cellular process phenotype in which vegetative cell population growth does not occur, although cells remain viable." [PomBase:mah] comment: This term's primary purpose is to organize terms beneath it in the ontology, and we recommend that it not be used for direct annotations. Please consider using one of the more specific terms, which mention carbon or nitrogen sources, to annotate each phenotype, as cells that do not grow on any media would be considered inviable. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "abolished growth of population of viable vegetative cells" EXACT [PomBase:mah] synonym: "abolished vegetative cell population growth, viable cells" EXACT [PomBase:vw] synonym: "vegetative cell population growth abolished" EXACT [PomBase:mah] synonym: "vegetative population growth abolished" EXACT [PomBase:mah] is_a: FYPO:0001355 ! decreased vegetative cell population growth is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0072690 ! single-celled organism vegetative growth phase created_by: midori creation_date: 2012-09-20T14:52:12Z [Term] id: FYPO:0001576 name: abolished cell population growth on dipeptide nitrogen source def: "A vegetative cell population growth phenotype in which a cell population does not grow in a medium containing a dipeptide such as Leu-Ala as the nitrogen source." [PomBase:mah] comment: Use this term for a population of cells that does not grow with a dipeptide as the nitrogen source, but does grow using a different nitrogen source (a cell population that does not grow on any media would be considered inviable). Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "abolished dipeptide utilization" RELATED [PomBase:mah, PomBase:vw] synonym: "abolished vegetative cell population growth on dipeptide nitrogen source" EXACT [PomBase:mah] synonym: "cell population growth on dipeptide nitrogen source abolished" EXACT [PomBase:mah] is_a: FYPO:0001575 ! abolished vegetative cell population growth intersection_of: FYPO:0001575 ! abolished vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:46761 ! dipeptide relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:46761 ! dipeptide created_by: midori creation_date: 2012-09-20T15:01:27Z [Term] id: FYPO:0001577 name: abolished cell population growth on tetrapeptide nitrogen source def: "A vegetative cell population growth phenotype in which a cell population does not grow in a medium containing a tetrapeptide such as Leu-Ser-Lys-Leu as the nitrogen source." [PomBase:mah] comment: Use this term for a population of cells that does not grow with a tetrapeptide as the nitrogen source, but does grow using a different nitrogen source (a cell population that does not grow on any media would be considered inviable). Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "abolished growth on tetrapeptide nitrogen source" BROAD [PomBase:mah] synonym: "abolished tetrapeptide utilization" RELATED [PomBase:mah, PomBase:vw] synonym: "abolished vegetative cell population growth on tetrapeptide nitrogen source" EXACT [PomBase:mah] synonym: "cell population growth on tetrapeptide nitrogen source abolished" EXACT [PomBase:mah] is_a: FYPO:0001575 ! abolished vegetative cell population growth intersection_of: FYPO:0001575 ! abolished vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:48030 ! tetrapeptide relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:48030 ! tetrapeptide created_by: midori creation_date: 2012-09-20T15:03:18Z [Term] id: FYPO:0001578 name: normal growth on dipeptide nitrogen source def: "A vegetative cell population growth phenotype in which cells grow normally in a medium containing a dipeptide such as Leu-Ala as the nitrogen source." [PomBase:mah] synonym: "normal cell population growth on dipeptide nitrogen source" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal dipeptide utilization" RELATED [PomBase:mah, PomBase:vw] synonym: "normal vegetative cell population growth on dipeptide nitrogen source" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0000047 ! normal cell population growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:46761 ! dipeptide relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:46761 ! dipeptide created_by: midori creation_date: 2012-09-20T15:07:14Z [Term] id: FYPO:0001579 name: normal growth on tetrapeptide nitrogen source def: "A vegetative cell population growth phenotype in which cells grow normally in a medium containing a tetrapeptide such as Leu-Ser-Lys-Leu as the nitrogen source." [PomBase:mah] synonym: "normal cell population growth on tetrapeptide nitrogen source" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal tetrapeptide utilization" RELATED [PomBase:mah, PomBase:vw] synonym: "normal vegetative cell population growth on tetrapeptide nitrogen source" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0000047 ! normal cell population growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:48030 ! tetrapeptide relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:48030 ! tetrapeptide created_by: midori creation_date: 2012-09-20T15:08:09Z [Term] id: FYPO:0001580 name: normal growth on leucine nitrogen source def: "A vegetative cell population growth phenotype in which cells grow normally in a medium containing leucine as the nitrogen source." [PomBase:mah] synonym: "normal cell population growth on leucine nitrogen source" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cell population growth on monomeric leucine nitrogen source" EXACT [PomBase:vw] synonym: "normal leucine utilization" RELATED [PomBase:mah, PomBase:vw] synonym: "normal monomeric leucine utilization" RELATED [PomBase:vw] synonym: "normal vegetative cell population growth on leucine nitrogen source" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0000047 ! normal cell population growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:15603 ! L-leucine relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:15603 ! L-leucine created_by: midori creation_date: 2012-09-20T15:08:58Z [Term] id: FYPO:0001581 name: vacuolated def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which vacuoles are more visible (usually by microscopy) than normal. A vacuolated phenotype may be due to the presence of more vacuoles in a cell than normal, or to vacuoles located nearer the cell surface (and hence more visible) than normal." [PomBase:mah] comment: Also see 'abnormal vacuole morphology (FYPO:0000368)' and 'vacuoles present in greater numbers' (FYPO:0000952). synonym: "vacuolated during mitotic cell cycle" RELATED [PomBase:mah] synonym: "vacuolated during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth created_by: midori creation_date: 2012-09-20T15:57:31Z [Term] id: FYPO:0001582 name: normal growth on glutathione def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing glutathione." [PomBase:mah] synonym: "normal cell population growth in presence of glutathione" EXACT [PomBase:mah] synonym: "normal cell population growth on glutathione" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cell population growth on GSH" EXACT [CHEBI:16856] synonym: "normal cell population growth on L-gamma-glutamyl-L-cysteinylglycine" EXACT [CHEBI:16856] synonym: "normal cell population growth on reduced glutathione" EXACT [CHEBI:16856] synonym: "normal cellular response to glutathione" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on glutathione" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:16856 ! glutathione relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:16856 ! glutathione created_by: midori creation_date: 2012-09-20T16:02:56Z [Term] id: FYPO:0001583 name: resistance to lithium def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of lithium ions than normal." [PomBase:mah] synonym: "resistance to lithium during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to lithium during vegetative growth" EXACT [PomBase:mah] synonym: "resistance to lithium ion" EXACT [PomBase:mah] synonym: "resistant to lithium" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:49713 ! lithium(1+) relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:49713 ! lithium(1+) created_by: midori creation_date: 2012-09-21T15:24:01Z [Term] id: FYPO:0001584 name: abnormal protein localization to cell tip def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the cell tip is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found at the cell tip and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to cell tip" EXACT [GO:0034504, PomBase:mah] synonym: "abnormal protein localization to cell tip during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein localization to cell tip during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000443 ! abnormal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1990151 ! protein localization to cell tip intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1990151 ! protein localization to cell tip relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-09-21T15:26:12Z [Term] id: FYPO:0001585 name: abolished protein localization to cell tip def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the cell tip is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to cell tip" EXACT [PomBase:mah] synonym: "abolished protein localization to cell tip during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to cell tip during vegetative growth" EXACT [PomBase:mah] synonym: "protein localization to cell tip abolished" EXACT [PomBase:mah] is_a: FYPO:0001179 ! protein localization abolished during vegetative growth is_a: FYPO:0001584 ! abnormal protein localization to cell tip intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1990151 ! protein localization to cell tip relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1990151 ! protein localization to cell tip created_by: midori creation_date: 2012-09-21T15:26:25Z [Term] id: FYPO:0001586 name: decreased protein localization to cell tip def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the cell tip is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to cell tip" EXACT [GO:0034504, PomBase:mah] synonym: "decreased protein localization to cell tip during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to cell tip during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to cell tip" EXACT [PomBase:mah] is_a: FYPO:0001584 ! abnormal protein localization to cell tip is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990151 ! protein localization to cell tip relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990151 ! protein localization to cell tip created_by: midori creation_date: 2012-09-21T15:26:32Z [Term] id: FYPO:0001587 name: normal protein localization to cell tip def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the cell tip is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to cell tip" EXACT [PomBase:mah] synonym: "normal protein localization to cell tip during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to cell tip during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000644 ! normal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990151 ! protein localization to cell tip intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990151 ! protein localization to cell tip relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-09-21T15:26:58Z [Term] id: FYPO:0001588 name: decreased lysine import during nitrogen starvation def: "A cellular process phenotype in which the import of lysine into the cell occurs to a lower extent than normal when the cell is subject to nitrogen starvation." [PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "decreased L-lysine import during nitrogen starvation" EXACT [PomBase:mah] synonym: "decreased lysine import during nitrogen depletion" EXACT [PomBase:vw] synonym: "decreased lysine import during nitrogen deprivation" EXACT [PomBase:vw] synonym: "decreased lysine import into cell during nitrogen starvation" EXACT [PomBase:al] synonym: "decreased lysine transport into cell during nitrogen starvation" EXACT [PomBase:al] synonym: "decreased lysine uptake during nitrogen starvation" EXACT [PomBase:mah] synonym: "reduced lysine import during nitrogen starvation" EXACT [PomBase:mah] is_a: FYPO:0001650 ! decreased lysine import is_a: FYPO:0001652 ! abnormal lysine import during nitrogen starvation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in GO:1903410 ! L-lysine import into cell relationship: happens_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in GO:1903410 ! L-lysine import into cell created_by: midori creation_date: 2012-09-27T11:07:56Z [Term] id: FYPO:0001589 name: decreased glutamate import during nitrogen starvation def: "A cellular process phenotype in which the import of glutamate into the cell occurs to a lower extent than normal when the cell is subject to nitrogen starvation." [PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "decreased glutamate import during nitrogen depletion" EXACT [PomBase:vw] synonym: "decreased glutamate import during nitrogen deprivation" EXACT [PomBase:vw] synonym: "decreased glutamate import into cell during nitrogen starvation" EXACT [PomBase:al] synonym: "decreased glutamate transport into cell during nitrogen starvation" EXACT [PomBase:al] synonym: "decreased glutamate uptake during nitrogen starvation" EXACT [PomBase:mah] synonym: "decreased L-glutamate import during nitrogen starvation" EXACT [PomBase:mah] synonym: "reduced glutamate import during nitrogen starvation" EXACT [PomBase:mah] is_a: FYPO:0001647 ! abnormal glutamate import during nitrogen starvation is_a: FYPO:0001649 ! decreased glutamate import intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in GO:1990123 ! L-glutamate import into cell relationship: happens_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in GO:1990123 ! L-glutamate import into cell created_by: midori creation_date: 2012-09-27T11:08:38Z [Term] id: FYPO:0001590 name: decreased lysine import during vegetative growth def: "A cellular process phenotype in which the import of lysine into the cell occurs to a lower extent than normal in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "decreased L-lysine import during vegetative growth" EXACT [PomBase:mah] synonym: "decreased lysine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased lysine import into cell during vegetative growth" EXACT [PomBase:al] synonym: "decreased lysine uptake during vegetative growth" EXACT [PomBase:mah] synonym: "reduced lysine import during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001360 ! decreased amino acid import during vegetative growth is_a: FYPO:0001650 ! decreased lysine import is_a: FYPO:0001653 ! abnormal lysine import during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903410 ! L-lysine import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903410 ! L-lysine import into cell created_by: midori creation_date: 2012-09-27T11:36:23Z [Term] id: FYPO:0001591 name: decreased histidine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of histidine into the cell occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased histidine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histidine import during vegetative growth" EXACT [PomBase:mah] synonym: "decreased histidine import into cell" EXACT [PomBase:al] synonym: "decreased histidine uptake" EXACT [PomBase:mah] synonym: "decreased L-histidine import" EXACT [PomBase:mah] synonym: "reduced histidine import" EXACT [PomBase:mah] is_a: FYPO:0001360 ! decreased amino acid import during vegetative growth is_a: FYPO:0001655 ! abnormal histidine import intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903810 ! L-histidine import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903810 ! L-histidine import into cell created_by: midori creation_date: 2012-09-27T11:37:19Z [Term] id: FYPO:0001592 name: decreased arginine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of arginine into the cell occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased arginine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased arginine import during vegetative growth" EXACT [PomBase:mah] synonym: "decreased arginine import into cell" EXACT [PomBase:al] synonym: "decreased arginine uptake" EXACT [PomBase:mah] synonym: "decreased L-arginine import" EXACT [PomBase:mah] synonym: "reduced arginine import" EXACT [PomBase:mah] is_a: FYPO:0001360 ! decreased amino acid import during vegetative growth is_a: FYPO:0001654 ! abnormal arginine import intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902765 ! L-arginine import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902765 ! L-arginine import into cell created_by: midori creation_date: 2012-09-27T11:59:09Z [Term] id: FYPO:0001593 name: decreased valine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of valine into the cell occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased L-valine import" EXACT [PomBase:mah] synonym: "decreased valine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased valine import during vegetative growth" EXACT [PomBase:mah] synonym: "decreased valine import into cell" EXACT [PomBase:al] synonym: "decreased valine uptake" EXACT [PomBase:mah] synonym: "reduced valine import" EXACT [PomBase:mah] is_a: FYPO:0001360 ! decreased amino acid import during vegetative growth is_a: FYPO:0001658 ! abnormal valine import intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903805 ! L-valine import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903805 ! L-valine import into cell created_by: midori creation_date: 2012-09-27T11:59:59Z [Term] id: FYPO:0001594 name: decreased asparagine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of asparagine into the cell occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased asparagine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased asparagine import during vegetative growth" EXACT [PomBase:mah] synonym: "decreased asparagine import into cell" EXACT [PomBase:al] synonym: "decreased asparagine uptake" EXACT [PomBase:mah] synonym: "decreased L-asparagine import" EXACT [PomBase:mah] synonym: "reduced asparagine import" EXACT [PomBase:mah] is_a: FYPO:0001360 ! decreased amino acid import during vegetative growth is_a: FYPO:0001656 ! abnormal asparagine import intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903811 ! L-asparagine import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903811 ! L-asparagine import into cell created_by: midori creation_date: 2012-09-27T12:00:40Z [Term] id: FYPO:0001595 name: decreased serine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of serine into the cell occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased L-serine import" EXACT [PomBase:mah] synonym: "decreased serine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased serine import during vegetative growth" EXACT [PomBase:mah] synonym: "decreased serine import into cell" EXACT [PomBase:al] synonym: "decreased serine uptake" EXACT [PomBase:mah] synonym: "reduced serine import" EXACT [PomBase:mah] is_a: FYPO:0001360 ! decreased amino acid import during vegetative growth is_a: FYPO:0001657 ! abnormal serine import intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903812 ! L-serine import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903812 ! L-serine import into cell created_by: midori creation_date: 2012-09-27T12:01:24Z [Term] id: FYPO:0001596 name: normal amino acid import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which amino acid import is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal amino acid import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal amino acid import during vegetative growth" EXACT [PomBase:mah] synonym: "normal amino acid import into cell" EXACT [PomBase:al] synonym: "normal amino acid uptake" EXACT [PomBase:mah] is_a: FYPO:0001071 ! normal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902837 ! amino acid import into cell intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902837 ! amino acid import into cell relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-09-27T12:17:29Z [Term] id: FYPO:0001597 name: normal valine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which valine import is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal L-valine import" EXACT [PomBase:mah] synonym: "normal valine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal valine import during vegetative growth" EXACT [PomBase:mah] synonym: "normal valine import into cell" EXACT [PomBase:al] synonym: "normal valine uptake" EXACT [PomBase:mah] is_a: FYPO:0001596 ! normal amino acid import intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903805 ! L-valine import into cell intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903805 ! L-valine import into cell relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-09-27T12:22:29Z [Term] id: FYPO:0001598 name: normal glutamine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which glutamine import is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal glutamine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal glutamine import during vegetative growth" EXACT [PomBase:mah] synonym: "normal glutamine import into cell" EXACT [PomBase:al] synonym: "normal glutamine uptake" EXACT [PomBase:mah] synonym: "normal L-glutamine import" EXACT [PomBase:mah] is_a: FYPO:0001596 ! normal amino acid import intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903803 ! L-glutamine import into cell intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903803 ! L-glutamine import into cell relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-09-27T12:23:11Z [Term] id: FYPO:0001599 name: normal asparagine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which asparagine import is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal asparagine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal asparagine import during vegetative growth" EXACT [PomBase:mah] synonym: "normal asparagine import into cell" EXACT [PomBase:al] synonym: "normal asparagine uptake" EXACT [PomBase:mah] synonym: "normal L-asparagine import" EXACT [PomBase:mah] is_a: FYPO:0001596 ! normal amino acid import intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903811 ! L-asparagine import into cell intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903811 ! L-asparagine import into cell relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-09-27T12:23:36Z [Term] id: FYPO:0001600 name: normal isoleucine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which isoleucine import is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal isoleucine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal isoleucine import during vegetative growth" EXACT [PomBase:mah] synonym: "normal isoleucine import into cell" EXACT [PomBase:al] synonym: "normal isoleucine uptake" EXACT [PomBase:mah] synonym: "normal L-isoleucine import" EXACT [PomBase:mah] is_a: FYPO:0001596 ! normal amino acid import intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903806 ! L-isoleucine import into cell intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903806 ! L-isoleucine import into cell relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-09-27T12:24:12Z [Term] id: FYPO:0001601 name: altered level of substance in vacuole def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of a specific substance measured in the vacuole differs from normal." [PomBase:mah] synonym: "abnormal level of substance in vacuole" EXACT [PomBase:mah] synonym: "abnormal level of substance in vacuole during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal vacuolar level of substance" EXACT [PomBase:mah] synonym: "altered level of substance in vacuole during mitotic cell cycle" RELATED [PomBase:mah] synonym: "altered vacuolar level of substance" EXACT [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: FYPO:0001323 ! altered level of substance in cell during vegetative growth is_a: FYPO:0002794 ! abnormal vacuole intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:24431 ! chemical entity relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:24431 ! chemical entity created_by: midori creation_date: 2012-09-27T13:06:05Z [Term] id: FYPO:0001602 name: decreased level of substance in vacuole def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of a specific substance measured in the vacuole is lower than normal." [PomBase:mah] synonym: "decreased level of substance in vacuole during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased level of substance in vacuole during vegetative growth" EXACT [PomBase:mah] synonym: "decreased vacuolar level of substance" EXACT [PomBase:mah] synonym: "reduced level of substance in vacuole" EXACT [PomBase:mah] is_a: FYPO:0001329 ! decreased level of substance in cell during vegetative growth is_a: FYPO:0001601 ! altered level of substance in vacuole intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: towards CHEBI:24431 ! chemical entity relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: towards CHEBI:24431 ! chemical entity created_by: midori creation_date: 2012-09-27T13:07:26Z [Term] id: FYPO:0001603 name: normal level of substance in vacuole def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of a specific substance measured in the vacuole is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal level of substance in vacuole during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal level of substance in vacuole during vegetative growth" EXACT [PomBase:mah] synonym: "normal vacuolar level of substance" EXACT [PomBase:mah] is_a: FYPO:0001313 ! normal subcellular component during vegetative growth is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:24431 ! chemical entity relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:24431 ! chemical entity created_by: midori creation_date: 2012-09-27T13:07:41Z [Term] id: FYPO:0001604 name: altered level of substance in cytosol def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of a specific substance measured in the cytosol differs from normal." [PomBase:mah] synonym: "abnormal cytosolic level of substance" EXACT [PomBase:mah] synonym: "abnormal level of substance in cytosol" EXACT [PomBase:mah] synonym: "abnormal level of substance in cytosol during vegetative growth" EXACT [PomBase:mah] synonym: "altered cytosolic level of substance" EXACT [PomBase:mah] synonym: "altered level of substance in cytosol during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: FYPO:0001323 ! altered level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005829 ! cytosol intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:24431 ! chemical entity relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005829 ! cytosol relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:24431 ! chemical entity created_by: midori creation_date: 2012-09-27T13:17:34Z [Term] id: FYPO:0001605 name: decreased level of substance in cytosol def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of a specific substance measured in the cytosol is lower than normal." [PomBase:mah] synonym: "decreased cytosolic level of substance" EXACT [PomBase:mah] synonym: "decreased level of substance in cytosol during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased level of substance in cytosol during vegetative growth" EXACT [PomBase:mah] synonym: "reduced level of substance in cytosol" EXACT [PomBase:mah] is_a: FYPO:0001329 ! decreased level of substance in cell during vegetative growth is_a: FYPO:0001604 ! altered level of substance in cytosol intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005829 ! cytosol intersection_of: towards CHEBI:24431 ! chemical entity relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005829 ! cytosol relationship: towards CHEBI:24431 ! chemical entity created_by: midori creation_date: 2012-09-27T13:18:39Z [Term] id: FYPO:0001606 name: normal level of substance in cytosol def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of a specific substance measured in the cytosol is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cytosolic level of substance" EXACT [PomBase:mah] synonym: "normal level of substance in cytosol during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal level of substance in cytosol during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001313 ! normal subcellular component during vegetative growth is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005829 ! cytosol intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:24431 ! chemical entity relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005829 ! cytosol relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:24431 ! chemical entity created_by: midori creation_date: 2012-09-27T13:19:00Z [Term] id: FYPO:0001607 name: decreased vacuolar aspartate level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-aspartate measured in the vacuole is lower than normal." [PomBase:mah] synonym: "decreased level of aspartate in vacuole" EXACT [PomBase:mah] synonym: "decreased vacuolar aspartate level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased vacuolar aspartate level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased vacuolar aspartic acid level" RELATED [PomBase:mah] synonym: "decreased vacuolar L-aspartate level" EXACT [PomBase:mah] synonym: "reduced level of aspartate in vacuole" EXACT [PomBase:mah] synonym: "reduced vacuolar aspartate level" EXACT [PomBase:mah] is_a: FYPO:0001602 ! decreased level of substance in vacuole is_a: FYPO:0001613 ! decreased cellular aspartate level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: towards CHEBI:29993 ! L-aspartate(2-) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: towards CHEBI:29993 ! L-aspartate(2-) created_by: midori creation_date: 2012-09-27T13:35:58Z [Term] id: FYPO:0001608 name: decreased vacuolar glutamate level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-glutamate measured in the vacuole is lower than normal." [PomBase:mah] synonym: "decreased level of glutamate in vacuole" EXACT [PomBase:mah] synonym: "decreased vacuolar glutamate level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased vacuolar glutamate level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased vacuolar glutamic acid level" RELATED [PomBase:mah] synonym: "decreased vacuolar L-glutamate level" EXACT [PomBase:mah] synonym: "reduced level of glutamate in vacuole" EXACT [PomBase:mah] synonym: "reduced vacuolar glutamate level" EXACT [PomBase:mah] is_a: FYPO:0001563 ! decreased cellular glutamate level is_a: FYPO:0001602 ! decreased level of substance in vacuole intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: towards CHEBI:29989 ! D-glutamate(2-) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: towards CHEBI:29989 ! D-glutamate(2-) created_by: midori creation_date: 2012-09-27T13:37:52Z [Term] id: FYPO:0001609 name: decreased vacuolar ornithine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-ornithine measured in the vacuole is lower than normal." [PomBase:mah] synonym: "decreased level of ornithine in vacuole" EXACT [PomBase:mah] synonym: "decreased vacuolar L-ornithine level" EXACT [PomBase:mah] synonym: "decreased vacuolar ornithine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased vacuolar ornithine level during vegetative growth" EXACT [PomBase:mah] synonym: "reduced level of ornithine in vacuole" EXACT [PomBase:mah] synonym: "reduced vacuolar ornithine level" EXACT [PomBase:mah] is_a: FYPO:0001564 ! decreased cellular ornithine level is_a: FYPO:0001602 ! decreased level of substance in vacuole intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: towards CHEBI:15729 ! L-ornithine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: towards CHEBI:15729 ! L-ornithine created_by: midori creation_date: 2012-09-27T13:38:40Z [Term] id: FYPO:0001610 name: decreased vacuolar lysine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-lysine measured in the vacuole is lower than normal." [PomBase:mah] synonym: "decreased level of lysine in vacuole" EXACT [PomBase:mah] synonym: "decreased vacuolar L-lysine level" EXACT [PomBase:mah] synonym: "decreased vacuolar lysine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased vacuolar lysine level during vegetative growth" EXACT [PomBase:mah] synonym: "reduced level of lysine in vacuole" EXACT [PomBase:mah] synonym: "reduced vacuolar lysine level" EXACT [PomBase:mah] is_a: FYPO:0001602 ! decreased level of substance in vacuole is_a: FYPO:0001619 ! decreased cellular lysine level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: towards CHEBI:18019 ! L-lysine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: towards CHEBI:18019 ! L-lysine created_by: midori creation_date: 2012-09-27T13:40:52Z [Term] id: FYPO:0001611 name: decreased vacuolar histidine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-histidine measured in the vacuole is lower than normal." [PomBase:mah] synonym: "decreased level of histidine in vacuole" EXACT [PomBase:mah] synonym: "decreased vacuolar histidine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased vacuolar histidine level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased vacuolar L-histidine level" EXACT [PomBase:mah] synonym: "reduced level of histidine in vacuole" EXACT [PomBase:mah] synonym: "reduced vacuolar histidine level" EXACT [PomBase:mah] is_a: FYPO:0001562 ! decreased cellular histidine level is_a: FYPO:0001602 ! decreased level of substance in vacuole intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: towards CHEBI:15971 ! L-histidine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: towards CHEBI:15971 ! L-histidine created_by: midori creation_date: 2012-09-27T13:41:34Z [Term] id: FYPO:0001612 name: decreased vacuolar arginine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-arginine measured in the vacuole is lower than normal." [PomBase:mah] synonym: "decreased level of arginine in vacuole" EXACT [PomBase:mah] synonym: "decreased vacuolar arginine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased vacuolar arginine level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased vacuolar L-arginine level" EXACT [PomBase:mah] synonym: "reduced level of arginine in vacuole" EXACT [PomBase:mah] synonym: "reduced vacuolar arginine level" EXACT [PomBase:mah] is_a: FYPO:0001602 ! decreased level of substance in vacuole is_a: FYPO:0001621 ! decreased cellular arginine level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: towards CHEBI:16467 ! L-arginine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: towards CHEBI:16467 ! L-arginine created_by: midori creation_date: 2012-09-27T13:42:12Z [Term] id: FYPO:0001613 name: decreased cellular aspartate level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-aspartate measured in the cell is lower than normal." [PomBase:mah] synonym: "decreased cellular aspartate level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular aspartate level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased cellular aspartic acid level" RELATED [PomBase:mah] synonym: "decreased cellular L-aspartate level" EXACT [PomBase:mah] synonym: "decreased cellular level aspartate level" EXACT [PomBase:mah] synonym: "decreased level of aspartate in cell" EXACT [PomBase:mah] synonym: "reduced cellular aspartate level" EXACT [PomBase:mah] synonym: "reduced level of aspartate in cell" EXACT [PomBase:mah] is_a: FYPO:0001329 ! decreased level of substance in cell during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:29993 ! L-aspartate(2-) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:29993 ! L-aspartate(2-) created_by: midori creation_date: 2012-09-27T13:57:23Z [Term] id: FYPO:0001616 name: decreased cellular valine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-valine measured in the cell is lower than normal." [PomBase:mah] synonym: "decreased cellular L-valine level" EXACT [PomBase:mah] synonym: "decreased cellular valine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular valine level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased level of valine in cell" EXACT [PomBase:mah] synonym: "reduced cellular valine level" EXACT [PomBase:mah] synonym: "reduced level of valine in cell" EXACT [PomBase:mah] is_a: FYPO:0003985 ! decreased cellular amino acid level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:16414 ! L-valine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:16414 ! L-valine created_by: midori creation_date: 2012-09-27T14:00:08Z [Term] id: FYPO:0001617 name: decreased cellular isoleucine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-isoleucine measured in the cell is lower than normal." [PomBase:mah] synonym: "decreased cellular isoleucine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular isoleucine level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased cellular L-isoleucine level" EXACT [PomBase:mah] synonym: "decreased level of isoleucine in cell" EXACT [PomBase:mah] synonym: "reduced cellular isoleucine level" EXACT [PomBase:mah] synonym: "reduced level of isoleucine in cell" EXACT [PomBase:mah] is_a: FYPO:0003985 ! decreased cellular amino acid level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:17191 ! L-isoleucine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:17191 ! L-isoleucine created_by: midori creation_date: 2012-09-27T14:02:19Z [Term] id: FYPO:0001619 name: decreased cellular lysine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-lysine measured in the cell is lower than normal." [PomBase:mah] synonym: "decreased cellular L-lysine level" EXACT [PomBase:mah] synonym: "decreased cellular lysine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular lysine level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased level of lysine in cell" EXACT [PomBase:mah] synonym: "reduced cellular lysine level" EXACT [PomBase:mah] synonym: "reduced level of lysine in cell" EXACT [PomBase:mah] is_a: FYPO:0003985 ! decreased cellular amino acid level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:18019 ! L-lysine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:18019 ! L-lysine created_by: midori creation_date: 2012-09-27T14:03:22Z [Term] id: FYPO:0001621 name: decreased cellular arginine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-arginine measured in the cell is lower than normal." [PomBase:mah] synonym: "decreased cellular arginine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular arginine level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased cellular L-arginine level" EXACT [PomBase:mah] synonym: "decreased level of arginine in cell" EXACT [PomBase:mah] synonym: "reduced cellular arginine level" EXACT [PomBase:mah] synonym: "reduced level of arginine in cell" EXACT [PomBase:mah] is_a: FYPO:0003985 ! decreased cellular amino acid level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:16467 ! L-arginine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:16467 ! L-arginine created_by: midori creation_date: 2012-09-27T14:04:37Z [Term] id: FYPO:0001622 name: normal vacuolar threonine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-threonine measured in the vacuole is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal level of threonine in vacuole" EXACT [PomBase:mah] synonym: "normal vacuolar L-threonine level" EXACT [PomBase:mah] synonym: "normal vacuolar threonine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal vacuolar threonine level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001603 ! normal level of substance in vacuole intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:16857 ! L-threonine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:16857 ! L-threonine created_by: midori creation_date: 2012-09-27T14:07:43Z [Term] id: FYPO:0001623 name: normal vacuolar serine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-serine measured in the vacuole is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal level of serine in vacuole" EXACT [PomBase:mah] synonym: "normal vacuolar L-serine level" EXACT [PomBase:mah] synonym: "normal vacuolar serine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal vacuolar serine level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001603 ! normal level of substance in vacuole is_a: FYPO:0001635 ! normal cellular serine level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:17115 ! L-serine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:17115 ! L-serine created_by: midori creation_date: 2012-09-27T14:15:13Z [Term] id: FYPO:0001624 name: normal vacuolar asparagine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-asparagine measured in the vacuole is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal level of asparagine in vacuole" EXACT [PomBase:mah] synonym: "normal vacuolar asparagine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal vacuolar asparagine level during vegetative growth" EXACT [PomBase:mah] synonym: "normal vacuolar L-asparagine level" EXACT [PomBase:mah] is_a: FYPO:0001603 ! normal level of substance in vacuole intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:17196 ! L-asparagine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:17196 ! L-asparagine created_by: midori creation_date: 2012-09-27T14:15:39Z [Term] id: FYPO:0001625 name: normal vacuolar glutamine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-glutamine measured in the vacuole is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal level of glutamine in vacuole" EXACT [PomBase:mah] synonym: "normal vacuolar glutamine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal vacuolar glutamine level during vegetative growth" EXACT [PomBase:mah] synonym: "normal vacuolar L-glutamine level" EXACT [PomBase:mah] is_a: FYPO:0001603 ! normal level of substance in vacuole is_a: FYPO:0001636 ! normal cellular glutamine level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:18050 ! L-glutamine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:18050 ! L-glutamine created_by: midori creation_date: 2012-09-27T14:16:08Z [Term] id: FYPO:0001626 name: normal vacuolar glycine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of glycine measured in the vacuole is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal level of glycine in vacuole" EXACT [PomBase:mah] synonym: "normal vacuolar glycine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal vacuolar glycine level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001603 ! normal level of substance in vacuole is_a: FYPO:0001637 ! normal cellular glycine level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:15428 ! glycine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:15428 ! glycine created_by: midori creation_date: 2012-09-27T14:16:32Z [Term] id: FYPO:0001627 name: normal vacuolar alanine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-alanine measured in the vacuole is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal level of alanine in vacuole" EXACT [PomBase:mah] synonym: "normal vacuolar alanine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal vacuolar alanine level during vegetative growth" EXACT [PomBase:mah] synonym: "normal vacuolar L-alanine level" EXACT [PomBase:mah] is_a: FYPO:0001603 ! normal level of substance in vacuole is_a: FYPO:0001638 ! normal cellular alanine level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:16977 ! L-alanine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:16977 ! L-alanine created_by: midori creation_date: 2012-09-27T14:17:07Z [Term] id: FYPO:0001628 name: normal vacuolar valine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-valine measured in the vacuole is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal level of valine in vacuole" EXACT [PomBase:mah] synonym: "normal vacuolar L-valine level" EXACT [PomBase:mah] synonym: "normal vacuolar valine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal vacuolar valine level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001603 ! normal level of substance in vacuole is_a: FYPO:0002746 ! normal cellular valine level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:16414 ! L-valine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:16414 ! L-valine created_by: midori creation_date: 2012-09-27T14:18:04Z [Term] id: FYPO:0001629 name: normal vacuolar methionine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-methionine measured in the vacuole is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal level of methionine in vacuole" EXACT [PomBase:mah] synonym: "normal vacuolar L-methionine level" EXACT [PomBase:mah] synonym: "normal vacuolar methionine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal vacuolar methionine level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001603 ! normal level of substance in vacuole is_a: FYPO:0001639 ! normal cellular methionine level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:16643 ! L-methionine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:16643 ! L-methionine created_by: midori creation_date: 2012-09-27T14:18:27Z [Term] id: FYPO:0001630 name: normal vacuolar isoleucine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-isoleucine measured in the vacuole is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal level of isoleucine in vacuole" EXACT [PomBase:mah] synonym: "normal vacuolar isoleucine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal vacuolar isoleucine level during vegetative growth" EXACT [PomBase:mah] synonym: "normal vacuolar L-isoleucine level" EXACT [PomBase:mah] is_a: FYPO:0001603 ! normal level of substance in vacuole intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:17191 ! L-isoleucine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:17191 ! L-isoleucine created_by: midori creation_date: 2012-09-27T14:18:49Z [Term] id: FYPO:0001631 name: normal vacuolar leucine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-leucine measured in the vacuole is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal level of leucine in vacuole" EXACT [PomBase:mah] synonym: "normal vacuolar L-leucine level" EXACT [PomBase:mah] synonym: "normal vacuolar leucine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal vacuolar leucine level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001603 ! normal level of substance in vacuole is_a: FYPO:0001640 ! normal cellular leucine level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:15603 ! L-leucine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:15603 ! L-leucine created_by: midori creation_date: 2012-09-27T14:19:17Z [Term] id: FYPO:0001632 name: normal vacuolar tyrosine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-tyrosine measured in the vacuole is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal level of tyrosine in vacuole" EXACT [PomBase:mah] synonym: "normal vacuolar L-tyrosine level" EXACT [PomBase:mah] synonym: "normal vacuolar tyrosine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal vacuolar tyrosine level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001603 ! normal level of substance in vacuole is_a: FYPO:0001641 ! normal cellular tyrosine level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:17895 ! L-tyrosine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:17895 ! L-tyrosine created_by: midori creation_date: 2012-09-27T14:20:13Z [Term] id: FYPO:0001633 name: normal vacuolar phenylalanine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-phenylalanine measured in the vacuole is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal level of phenylalanine in vacuole" EXACT [PomBase:mah] synonym: "normal vacuolar L-phenylalanine level" EXACT [PomBase:mah] synonym: "normal vacuolar phenylalanine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal vacuolar phenylalanine level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001603 ! normal level of substance in vacuole is_a: FYPO:0001642 ! normal cellular phenylalanine level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:17295 ! L-phenylalanine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:17295 ! L-phenylalanine created_by: midori creation_date: 2012-09-27T14:20:37Z [Term] id: FYPO:0001634 name: normal vacuolar tryptophan level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of tryptophan measured in the vacuole is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal level of tryptophan in vacuole" EXACT [PomBase:mah] synonym: "normal vacuolar tryptophan level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal vacuolar tryptophan level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001603 ! normal level of substance in vacuole is_a: FYPO:0001643 ! normal cellular tryptophan level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:16828 ! L-tryptophan relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:16828 ! L-tryptophan created_by: midori creation_date: 2012-09-27T14:21:05Z [Term] id: FYPO:0001635 name: normal cellular serine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-serine measured in the cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular L-serine level" EXACT [PomBase:mah] synonym: "normal cellular serine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular serine level during vegetative growth" EXACT [PomBase:mah] synonym: "normal level of serine in cell" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:17115 ! L-serine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:17115 ! L-serine created_by: midori creation_date: 2012-09-27T14:42:14Z [Term] id: FYPO:0001636 name: normal cellular glutamine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-glutamine measured in the cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular glutamine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular glutamine level during vegetative growth" EXACT [PomBase:mah] synonym: "normal cellular L-glutamine level" EXACT [PomBase:mah] synonym: "normal level of glutamine in cell" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:18050 ! L-glutamine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:18050 ! L-glutamine created_by: midori creation_date: 2012-09-27T14:43:22Z [Term] id: FYPO:0001637 name: normal cellular glycine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-glycine measured in the cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular glycine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular glycine level during vegetative growth" EXACT [PomBase:mah] synonym: "normal cellular L-glycine level" EXACT [PomBase:mah] synonym: "normal level of glycine in cell" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:15428 ! glycine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:15428 ! glycine created_by: midori creation_date: 2012-09-27T14:43:46Z [Term] id: FYPO:0001638 name: normal cellular alanine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-alanine measured in the cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular alanine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular alanine level during vegetative growth" EXACT [PomBase:mah] synonym: "normal cellular L-alanine level" EXACT [PomBase:mah] synonym: "normal level of alanine in cell" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:16977 ! L-alanine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:16977 ! L-alanine created_by: midori creation_date: 2012-09-27T14:44:07Z [Term] id: FYPO:0001639 name: normal cellular methionine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-methionine measured in the cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular L-methionine level" EXACT [PomBase:mah] synonym: "normal cellular methionine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular methionine level during vegetative growth" EXACT [PomBase:mah] synonym: "normal level of methionine in cell" EXACT [PomBase:mah] is_a: FYPO:0001544 ! normal cellular sulfur level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:16643 ! L-methionine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:16643 ! L-methionine created_by: midori creation_date: 2012-09-27T14:44:34Z [Term] id: FYPO:0001640 name: normal cellular leucine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-leucine measured in the cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular L-leucine level" EXACT [PomBase:mah] synonym: "normal cellular leucine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular leucine level during vegetative growth" EXACT [PomBase:mah] synonym: "normal level of leucine in cell" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:15603 ! L-leucine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:15603 ! L-leucine created_by: midori creation_date: 2012-09-27T14:44:59Z [Term] id: FYPO:0001641 name: normal cellular tyrosine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-tyrosine measured in the cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular L-tyrosine level" EXACT [PomBase:mah] synonym: "normal cellular tyrosine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular tyrosine level during vegetative growth" EXACT [PomBase:mah] synonym: "normal level of tyrosine in cell" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:17895 ! L-tyrosine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:17895 ! L-tyrosine created_by: midori creation_date: 2012-09-27T14:45:39Z [Term] id: FYPO:0001642 name: normal cellular phenylalanine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-phenylalanine measured in the cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular L-phenylalanine level" EXACT [PomBase:mah] synonym: "normal cellular phenylalanine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular phenylalanine level during vegetative growth" EXACT [PomBase:mah] synonym: "normal level of phenylalanine in cell" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:17295 ! L-phenylalanine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:17295 ! L-phenylalanine created_by: midori creation_date: 2012-09-27T14:46:14Z [Term] id: FYPO:0001643 name: normal cellular tryptophan level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of tryptophan measured in the cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular tryptophan level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular tryptophan level during vegetative growth" EXACT [PomBase:mah] synonym: "normal level of tryptophan in cell" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:16828 ! L-tryptophan relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:16828 ! L-tryptophan created_by: midori creation_date: 2012-09-27T14:46:41Z [Term] id: FYPO:0001644 name: decreased cellular lithium level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of lithium ion measured in a cell is lower than normal." [PomBase:mah] synonym: "decreased cellular lithium ion level" EXACT [PomBase:mah] synonym: "decreased cellular lithium level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular lithium level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased lithium accumulation" RELATED [PomBase:al] synonym: "reduced cellular lithium level" EXACT [PomBase:mah] is_a: FYPO:0001329 ! decreased level of substance in cell during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:49713 ! lithium(1+) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:49713 ! lithium(1+) created_by: midori creation_date: 2012-09-27T14:48:30Z [Term] id: FYPO:0001645 name: decreased protein binding def: "A molecular function phenotype in which the binding of one protein to another occurs to a lower extent than normal. The relevant proteins may include the one encoded by the mutated gene, or may both be encoded by different genes." [PomBase:mah] comment: This term can be used for any protein-protein interaction that is affected by a mutation, whether or not the mutated gene product is one of the interacting proteins. We recommend noting which proteins were used in the assay when annotating to this term. synonym: "decreased protein-protein interaction" EXACT [PomBase:mah] synonym: "reduced protein binding" EXACT [PomBase:mah] is_a: FYPO:0000704 ! abnormal protein binding is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0005515 ! protein binding relationship: inheres_in GO:0005515 ! protein binding created_by: midori creation_date: 2012-09-27T14:50:07Z [Term] id: FYPO:0001646 name: abnormal glutamate import def: "A cellular process phenotype in which the import of glutamate into the cell is abnormal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "abnormal glutamate import into cell" EXACT [PomBase:al] synonym: "abnormal glutamate uptake" EXACT [PomBase:mah] synonym: "abnormal L-glutamate import" EXACT [PomBase:mah] is_a: FYPO:0001057 ! abnormal amino acid import intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:1990123 ! L-glutamate import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:1990123 ! L-glutamate import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-09-27T15:50:49Z [Term] id: FYPO:0001647 name: abnormal glutamate import during nitrogen starvation def: "A cellular process phenotype in which the import of L-glutamate into the cell is abnormal when the cell is subject to nitrogen starvation." [PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "abnormal glutamate import during nitrogen depletion" EXACT [PomBase:vw] synonym: "abnormal glutamate import during nitrogen deprivation" EXACT [PomBase:vw] synonym: "abnormal glutamate import into cell during nitrogen starvation" EXACT [PomBase:al] synonym: "abnormal glutamate uptake during nitrogen starvation" EXACT [PomBase:mah] synonym: "abnormal L-glutamate import during nitrogen starvation" EXACT [PomBase:mah] is_a: FYPO:0001646 ! abnormal glutamate import is_a: FYPO:0001648 ! abnormal amino acid import during nitrogen starvation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in_part_of GO:1990123 ! L-glutamate import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in_part_of GO:1990123 ! L-glutamate import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-09-27T15:51:52Z [Term] id: FYPO:0001648 name: abnormal amino acid import during nitrogen starvation def: "A cellular process phenotype in which the import of one or more amino acids into the cell is abnormal when the cell is subject to nitrogen starvation." [PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "abnormal amino acid import during nitrogen depletion" EXACT [PomBase:vw] synonym: "abnormal amino acid import during nitrogen deprivation" EXACT [PomBase:vw] synonym: "abnormal amino acid import into cell during nitrogen starvation" EXACT [PomBase:al] synonym: "abnormal amino acid uptake during nitrogen starvation" EXACT [PomBase:mah] is_a: FYPO:0001057 ! abnormal amino acid import intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in_part_of GO:1902837 ! amino acid import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in_part_of GO:1902837 ! amino acid import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-09-27T15:54:34Z [Term] id: FYPO:0001649 name: decreased glutamate import def: "A cellular process phenotype in which the import of glutamate into the cell occurs to a lower extent than normal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "decreased glutamate import into cell" EXACT [PomBase:al] synonym: "decreased glutamate uptake" EXACT [PomBase:mah] synonym: "decreased L-glutamate import" EXACT [PomBase:mah] synonym: "reduced glutamate import" EXACT [PomBase:mah] is_a: FYPO:0001058 ! decreased amino acid import is_a: FYPO:0001646 ! abnormal glutamate import intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:1990123 ! L-glutamate import into cell relationship: inheres_in GO:1990123 ! L-glutamate import into cell created_by: midori creation_date: 2012-09-27T15:56:47Z [Term] id: FYPO:0001650 name: decreased lysine import def: "A cellular process phenotype in which the import of lysine into the cell occurs to a lower extent than normal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "decreased L-lysine import" EXACT [PomBase:mah] synonym: "decreased lysine import into cell" EXACT [PomBase:al] synonym: "decreased lysine uptake" EXACT [PomBase:mah] synonym: "reduced lysine import" EXACT [PomBase:mah] is_a: FYPO:0001058 ! decreased amino acid import is_a: FYPO:0001651 ! abnormal lysine import intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:1903410 ! L-lysine import into cell relationship: inheres_in GO:1903410 ! L-lysine import into cell created_by: midori creation_date: 2012-09-27T15:59:41Z [Term] id: FYPO:0001651 name: abnormal lysine import def: "A cellular process phenotype in which the import of lysine into the cell is abnormal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "abnormal L-lysine import" EXACT [PomBase:mah] synonym: "abnormal lysine import into cell" EXACT [PomBase:al] synonym: "abnormal lysine uptake" EXACT [PomBase:mah] is_a: FYPO:0001057 ! abnormal amino acid import intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:1903410 ! L-lysine import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:1903410 ! L-lysine import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-09-27T16:06:07Z [Term] id: FYPO:0001652 name: abnormal lysine import during nitrogen starvation def: "A cellular process phenotype in which the import of lysine into the cell is abnormal when the cell is subject to nitrogen starvation." [PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "abnormal L-lysine import during nitrogen starvation" EXACT [PomBase:mah] synonym: "abnormal lysine import during nitrogen depletion" EXACT [PomBase:vw] synonym: "abnormal lysine import during nitrogen deprivation" EXACT [PomBase:vw] synonym: "abnormal lysine import into cell during nitrogen starvation" EXACT [PomBase:al] synonym: "abnormal lysine uptake during nitrogen starvation" EXACT [PomBase:mah] is_a: FYPO:0001648 ! abnormal amino acid import during nitrogen starvation is_a: FYPO:0001651 ! abnormal lysine import intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in_part_of GO:1903410 ! L-lysine import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in_part_of GO:1903410 ! L-lysine import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-09-27T16:07:08Z [Term] id: FYPO:0001653 name: abnormal lysine import during vegetative growth def: "A cellular process phenotype in which the import of lysine into the cell is abnormal in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "abnormal L-lysine import during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal lysine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal lysine import into cell during vegetative growth" EXACT [PomBase:al] synonym: "abnormal lysine uptake during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001361 ! abnormal amino acid import during vegetative growth is_a: FYPO:0001651 ! abnormal lysine import intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1903410 ! L-lysine import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1903410 ! L-lysine import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-09-27T16:07:33Z [Term] id: FYPO:0001654 name: abnormal arginine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of arginine into the cell is abnormal." [PomBase:mah] synonym: "abnormal arginine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal arginine import during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal arginine import into cell" EXACT [PomBase:al] synonym: "abnormal arginine uptake" EXACT [PomBase:mah] synonym: "abnormal L-arginine import" EXACT [PomBase:mah] is_a: FYPO:0001361 ! abnormal amino acid import during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1902765 ! L-arginine import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1902765 ! L-arginine import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-09-27T16:12:15Z [Term] id: FYPO:0001655 name: abnormal histidine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of histidine into the cell is abnormal." [PomBase:mah] synonym: "abnormal histidine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal histidine import during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal histidine import into cell" EXACT [PomBase:al] synonym: "abnormal histidine uptake" EXACT [PomBase:mah] synonym: "abnormal L-histidine import" EXACT [PomBase:mah] is_a: FYPO:0001361 ! abnormal amino acid import during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1903810 ! L-histidine import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1903810 ! L-histidine import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-09-27T16:13:44Z [Term] id: FYPO:0001656 name: abnormal asparagine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of asparagine into the cell is abnormal." [PomBase:mah] synonym: "abnormal asparagine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal asparagine import during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal asparagine import into cell" EXACT [PomBase:al] synonym: "abnormal asparagine uptake" EXACT [PomBase:mah] synonym: "abnormal L-asparagine import" EXACT [PomBase:mah] is_a: FYPO:0001361 ! abnormal amino acid import during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1903811 ! L-asparagine import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1903811 ! L-asparagine import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-09-27T16:15:26Z [Term] id: FYPO:0001657 name: abnormal serine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of serine into the cell is abnormal." [PomBase:mah] synonym: "abnormal L-serine import" EXACT [PomBase:mah] synonym: "abnormal serine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal serine import during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal serine import into cell" EXACT [PomBase:al] synonym: "abnormal serine uptake" EXACT [PomBase:mah] is_a: FYPO:0001361 ! abnormal amino acid import during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1903812 ! L-serine import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1903812 ! L-serine import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-09-27T16:16:18Z [Term] id: FYPO:0001658 name: abnormal valine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of valine into the cell is abnormal." [PomBase:mah] synonym: "abnormal L-valine import" EXACT [PomBase:mah] synonym: "abnormal valine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal valine import during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal valine import into cell" EXACT [PomBase:al] synonym: "abnormal valine uptake" EXACT [PomBase:mah] is_a: FYPO:0001361 ! abnormal amino acid import during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1903805 ! L-valine import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1903805 ! L-valine import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-09-27T16:17:09Z [Term] id: FYPO:0001659 name: altered cellular cAMP level def: "A cell phenotype in which the amount of cyclic AMP measured in a cell differs from normal." [PomBase:mah] synonym: "abnormal cellular cAMP accumulation" RELATED [PomBase:mah] synonym: "abnormal cellular cAMP level" EXACT [PomBase:mah] synonym: "altered cellular cyclic AMP level" EXACT [PomBase:mah] is_a: FYPO:0000989 ! altered level of substance in cell intersection_of: PATO:0001159 ! concentrated intersection_of: inheres_in CL:0000000 ! cell intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:17489 ! 3',5'-cyclic AMP relationship: inheres_in CL:0000000 ! cell relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:17489 ! 3',5'-cyclic AMP created_by: midori creation_date: 2012-10-03T15:56:44Z [Term] id: FYPO:0001660 name: decreased cellular cAMP level def: "A cell phenotype in which the amount of cyclic AMP measured in a cell is lower than normal." [PomBase:mah] synonym: "decreased cellular cAMP accumulation" RELATED [PomBase:mah] synonym: "decreased cellular cyclic AMP level" EXACT [PomBase:mah] synonym: "reduced cellular cAMP level" EXACT [PomBase:mah] is_a: FYPO:0000991 ! decreased level of substance in cell is_a: FYPO:0001659 ! altered cellular cAMP level intersection_of: PATO:0001163 ! decreased concentration intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:17489 ! 3',5'-cyclic AMP relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:17489 ! 3',5'-cyclic AMP created_by: midori creation_date: 2012-10-03T15:56:53Z [Term] id: FYPO:0001661 name: increased cellular cAMP level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of cyclic AMP measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cAMP accumulation" RELATED [PomBase:mah] synonym: "increased cellular cAMP level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular cAMP level during vegetative growth" EXACT [PomBase:mah] synonym: "increased cellular cyclic AMP level" EXACT [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth is_a: FYPO:0001659 ! altered cellular cAMP level intersection_of: PATO:0001162 ! increased concentration intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:17489 ! 3',5'-cyclic AMP relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:17489 ! 3',5'-cyclic AMP created_by: midori creation_date: 2012-10-03T15:57:15Z [Term] id: FYPO:0001662 name: decreased cellular cAMP level during glucose starvation def: "A cell phenotype in which the amount of trehalose measured in a cell is lower than normal when the cell is subject to glucose starvation." [PomBase:mah] synonym: "decreased cellular cAMP accumulation during glucose starvation" RELATED [PomBase:mah] synonym: "decreased cellular cAMP level during glucose depletion" EXACT [PomBase:vw] synonym: "decreased cellular cAMP level during glucose deprivation" EXACT [PomBase:vw] synonym: "decreased cellular cyclic AMP level during cellular response to glucose starvation" EXACT [PomBase:mah] synonym: "reduced cellular cAMP level during glucose starvation" EXACT [PomBase:mah] is_a: FYPO:0001660 ! decreased cellular cAMP level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0042149 ! cellular response to glucose starvation intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:17489 ! 3',5'-cyclic AMP relationship: exists_during GO:0042149 ! cellular response to glucose starvation relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:17489 ! 3',5'-cyclic AMP created_by: midori creation_date: 2012-10-03T15:57:38Z [Term] id: FYPO:0001663 name: increased cellular cAMP level during glucose starvation def: "A cell phenotype in which the amount of cyclic AMP measured in a cell is higher than normal when the cell is subject to glucose starvation." [PomBase:mah] synonym: "increased cAMP accumulation during cellular response to glucose starvation" RELATED [PomBase:mah] synonym: "increased cellular cAMP level during glucose depletion" EXACT [PomBase:vw] synonym: "increased cellular cAMP level during glucose deprivation" EXACT [PomBase:vw] synonym: "increased cellular cAMP level in response to glucose starvation" EXACT [PomBase:al] synonym: "increased cellular cyclic AMP level and during cellular response to glucose starvation" EXACT [PomBase:mah] is_a: FYPO:0001661 ! increased cellular cAMP level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0042149 ! cellular response to glucose starvation intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:17489 ! 3',5'-cyclic AMP relationship: exists_during GO:0042149 ! cellular response to glucose starvation relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:17489 ! 3',5'-cyclic AMP created_by: midori creation_date: 2012-10-03T15:58:30Z [Term] id: FYPO:0001664 name: increased cellular cAMP level during cellular response to glucose stimulus def: "A cell phenotype in which the amount of cyclic AMP measured in a cell is higher than normal during a cellular response to glucose stimulus." [PomBase:mah] synonym: "increased cAMP accumulation during cellular response to glucose stimulus" RELATED [PomBase:mah] synonym: "increased cellular cAMP level in response to glucose stimulus" EXACT [PomBase:al] synonym: "increased cellular cyclic AMP level during cellular response to glucose stimulus" EXACT [PomBase:mah] is_a: FYPO:0001661 ! increased cellular cAMP level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0071333 ! cellular response to glucose stimulus intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:17489 ! 3',5'-cyclic AMP relationship: exists_during GO:0071333 ! cellular response to glucose stimulus relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:17489 ! 3',5'-cyclic AMP created_by: midori creation_date: 2012-10-03T16:03:24Z [Term] id: FYPO:0001665 name: decreased cellular cAMP level during cellular response to glucose stimulus def: "A cell phenotype in which the amount of cyclic AMP measured in a cell is higher than normal during a cellular response to glucose stimulus." [PomBase:mah] synonym: "decreased cAMP accumulation during cellular response to glucose stimulus" RELATED [PomBase:mah] synonym: "decreased cellular cAMP level in response to glucose stimulus" EXACT [PomBase:al] synonym: "decreased cellular cyclic AMP level during cellular response to glucose stimulus" EXACT [PomBase:mah] synonym: "reduced cellular cAMP level during cellular response to glucose stimulus" EXACT [PomBase:mah] is_a: FYPO:0001660 ! decreased cellular cAMP level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0071333 ! cellular response to glucose stimulus intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:17489 ! 3',5'-cyclic AMP relationship: exists_during GO:0071333 ! cellular response to glucose stimulus relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:17489 ! 3',5'-cyclic AMP created_by: midori creation_date: 2012-10-03T16:07:39Z [Term] id: FYPO:0001666 name: normal cAMP level def: "A cell phenotype in which the amount of cyclic AMP measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular cAMP level" EXACT [PomBase:mah] synonym: "normal cyclic AMY level" EXACT [PomBase:mah] is_a: FYPO:0001076 ! normal level of substance in cell intersection_of: PATO:0001159 ! concentrated intersection_of: inheres_in CL:0000000 ! cell intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:17489 ! 3',5'-cyclic AMP relationship: inheres_in CL:0000000 ! cell relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:17489 ! 3',5'-cyclic AMP created_by: midori creation_date: 2012-10-03T16:09:21Z [Term] id: FYPO:0001667 name: normal cAMP level during glucose starvation def: "A cell phenotype in which the amount of cyclic AMP measured in a cell during glucose starvation is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cAMP accumulation during glucose starvation" RELATED [PomBase:mah] synonym: "normal cAMP level during glucose depletion" EXACT [PomBase:vw] synonym: "normal cAMP level during glucose deprivation" EXACT [PomBase:vw] synonym: "normal cellular cAMP level during glucose starvation" EXACT [PomBase:mah] synonym: "normal cyclic AMP level during glucose starvation" EXACT [PomBase:mah] is_a: FYPO:0001666 ! normal cAMP level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0042149 ! cellular response to glucose starvation intersection_of: inheres_in CL:0000000 ! cell intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:17489 ! 3',5'-cyclic AMP relationship: exists_during GO:0042149 ! cellular response to glucose starvation relationship: inheres_in CL:0000000 ! cell relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:17489 ! 3',5'-cyclic AMP created_by: midori creation_date: 2012-10-03T16:09:33Z [Term] id: FYPO:0001668 name: normal protein processing def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which protein processing is normal (i.e. indistinguishable from wild type). Protein processing is any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein." [GO:0016485, PomBase:mah] synonym: "normal protein processing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein processing during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001319 ! normal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0016485 ! protein processing intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0016485 ! protein processing relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-10-03T16:16:56Z [Term] id: FYPO:0001669 name: abolished protein processing def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the protein processing is abolished. Processing of all proteins or of one or more specific proteins may be affected. Protein processing is any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein." [GO:0016485, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein processing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein processing during vegetative growth" EXACT [PomBase:mah] synonym: "protein processing abolished" EXACT [PomBase:mah] is_a: FYPO:0001421 ! abnormal protein processing during vegetative growth is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0016485 ! protein processing relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0016485 ! protein processing created_by: midori creation_date: 2012-10-03T16:25:27Z [Term] id: FYPO:0001670 name: abnormal GDP binding def: "A molecular function phenotype in which occurrence of GDP binding by a gene product (usually a protein) in a mutant is abnormal. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] is_a: FYPO:0000707 ! abnormal molecular function is_a: FYPO:0001092 ! binding phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0019003 ! GDP binding intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0019003 ! GDP binding relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-10-03T16:29:51Z [Term] id: FYPO:0001671 name: decreased GDP binding def: "A molecular function phenotype in which occurrence of GDP binding by a gene product (usually a protein) in a mutant is decreased. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "reduced GDP binding" EXACT [PomBase:mah] is_a: FYPO:0001670 ! abnormal GDP binding is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0019003 ! GDP binding relationship: inheres_in GO:0019003 ! GDP binding created_by: midori creation_date: 2012-10-03T16:29:57Z [Term] id: FYPO:0001672 name: normal GTPase activity def: "A molecular function phenotype in which the observed rate of a GTPase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0003924 ! GTPase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0003924 ! GTPase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-10-03T16:35:01Z [Term] id: FYPO:0001673 name: normal nuclear morphology def: "A physical cellular phenotype in which the size, shape, or structure of the nucleus is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate is_a: FYPO:0001233 ! normal subcellular component is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: inheres_in GO:0005634 ! nucleus intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0005634 ! nucleus relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-10-09T10:53:23Z [Term] id: FYPO:0001674 name: abnormal L-aminoadipate-semialdehyde dehydrogenase activity def: "A molecular function phenotype in which the observed rate of L-aminoadipate-semialdehyde dehydrogenase activity is abnormal." [PomBase:mah] synonym: "abnormal alpha-aminoadipate reductase activity" EXACT [GO:0004043] is_a: FYPO:0000689 ! abnormal oxidoreductase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004043 ! L-aminoadipate-semialdehyde dehydrogenase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004043 ! L-aminoadipate-semialdehyde dehydrogenase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-10-11T14:46:46Z [Term] id: FYPO:0001675 name: increased L-aminoadipate-semialdehyde dehydrogenase activity def: "A molecular function phenotype in which the observed rate of L-aminoadipate-semialdehyde dehydrogenase activity is increased." [PomBase:mah] synonym: "increased alpha-aminoadipate reductase activity" EXACT [GO:0004043] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0001674 ! abnormal L-aminoadipate-semialdehyde dehydrogenase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0004043 ! L-aminoadipate-semialdehyde dehydrogenase activity relationship: inheres_in GO:0004043 ! L-aminoadipate-semialdehyde dehydrogenase activity created_by: midori creation_date: 2012-10-11T14:46:54Z [Term] id: FYPO:0001676 name: protein mislocalized to nucleus during S phase def: "A cell phenotype in which a protein that is not normally found in the nucleus is observed there during S phase of a mitotic cell cycle." [PomBase:mah] comment: Note that this term can be used to annotate any case where a protein is found in the nucleus in a mutant, but not in wild type. In some cases, there may be enough additional information to annotate to 'abnormal protein localization' (FYPO:0000443) or one of its descendants. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "ectopic protein localization to nucleus during S phase" EXACT [PomBase:vw] synonym: "protein mislocalised to nucleus during S phase" EXACT [PomBase:mah] synonym: "protein mislocalised to nucleus during S phase during vegetative growth" EXACT [PomBase:mah] synonym: "protein mislocalized to nucleus during S phase during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein mislocalized to nucleus during S phase during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000784 ! protein mislocalized to nucleus during vegetative growth intersection_of: PATO:0000628 ! mislocalised intersection_of: exists_during GO:0000084 ! mitotic S phase intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CHEBI:36080 ! protein intersection_of: towards GO:0005634 ! nucleus relationship: exists_during GO:0000084 ! mitotic S phase relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CHEBI:36080 ! protein relationship: towards GO:0005634 ! nucleus created_by: midori creation_date: 2012-10-11T16:20:13Z [Term] id: FYPO:0001677 name: increased protein localization to medial cortex during vegetative growth def: "A cell phenotype in which the localization of a protein to the medial cortex is increased in the vegetative growth phase of the life cycle." [PomBase:mah] comment: Encompasses both presence of proteins not normally found at the medial cortex and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to medial cortex during vegetative growth" EXACT [GO:0071574, PomBase:mah] synonym: "increased protein localization to medial cortex during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein localization to medial ring during vegetative growth" EXACT [GO:0031097, GO:0071574] is_a: FYPO:0000731 ! abnormal protein localization to medial cortex during vegetative growth is_a: FYPO:0004655 ! increased protein localization to cell division site intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071574 ! protein localization to medial cortex relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071574 ! protein localization to medial cortex created_by: midori creation_date: 2012-10-29T11:40:14Z [Term] id: FYPO:0001678 name: abolished protein localization to chromatin def: "A cell phenotype in which the localization of a protein to chromatin is abolished." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "abolished protein localisation to chromatin" EXACT [PomBase:mah] synonym: "protein localization to chromatin abolished" EXACT [PomBase:mah] is_a: FYPO:0001375 ! protein localization abolished is_a: FYPO:0001679 ! abnormal protein localization to chromatin intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0071168 ! protein localization to chromatin relationship: towards GO:0071168 ! protein localization to chromatin created_by: midori creation_date: 2012-10-30T15:29:03Z [Term] id: FYPO:0001679 name: abnormal protein localization to chromatin def: "A cell phenotype in which the localization of a protein to chromatin is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found associated with chromatin and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. subset: qc_do_not_manually_annotate synonym: "abnormal protein localisation to chromatin" EXACT [GO:0071168, PomBase:mah] is_a: FYPO:0001370 ! abnormal protein localization intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0071168 ! protein localization to chromatin intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0071168 ! protein localization to chromatin relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-10-30T15:39:19Z [Term] id: FYPO:0001680 name: abolished protein localization to chromatin during premeiotic DNA replication def: "A cell phenotype in which the localization of a protein to chromatin is abolished during the round of DNA replication that precedes meiosis I." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to chromatin during premeiotic DNA replication" EXACT [PomBase:mah] synonym: "protein localization to chromatin during premeiotic DNA replication abolished" EXACT [PomBase:mah] is_a: FYPO:0001678 ! abolished protein localization to chromatin intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0006279 ! premeiotic DNA replication intersection_of: towards GO:0071168 ! protein localization to chromatin relationship: during GO:0006279 ! premeiotic DNA replication relationship: towards GO:0071168 ! protein localization to chromatin created_by: midori creation_date: 2012-10-30T15:42:30Z [Term] id: FYPO:0001681 name: abolished protein localization to chromatin during S phase of meiotic cell cycle def: "A cell phenotype in which the localization of a protein to chromatin is abolished during S phase of a meiotic cell cycle." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to chromatin during S phase of meiotic cell cycle" EXACT [PomBase:mah] synonym: "protein localization to chromatin during S phase of meiotic cell cycle abolished" EXACT [PomBase:mah] is_a: FYPO:0001678 ! abolished protein localization to chromatin intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0051332 ! meiotic S phase intersection_of: towards GO:0071168 ! protein localization to chromatin relationship: during GO:0051332 ! meiotic S phase relationship: towards GO:0071168 ! protein localization to chromatin created_by: midori creation_date: 2012-10-30T15:50:10Z [Term] id: FYPO:0001682 name: normal alpha,alpha-trehalase activity increase during cellular response to salt stress def: "A molecular function phenotype in which the observed rate of alpha,alpha-trehalase activity increases normally (i.e. as in wild type) as a result of a salt stress." [PomBase:mah] synonym: "normal increase in trehalase activity in response to salt stress" EXACT [PomBase:al] synonym: "normal neutral trehalase activity increase during cellular response to salt stress" EXACT [PMID:9729425, PomBase:mah] synonym: "normal trehalase activity increase during cellular response to salt stress" BROAD [GO:0004555, GO:0015927] is_a: FYPO:0001480 ! normal alpha,alpha-trehalase activity created_by: midori creation_date: 2012-11-02T14:52:25Z [Term] id: FYPO:0001683 name: abolished mitotic spindle assembly def: "A cell phenotype in which mitotic spindle assembly does not occur." [PomBase:mah] synonym: "abolished mitotic spindle assembly during vegetative growth" EXACT [PomBase:mah] synonym: "spindle assembly involved in mitosis abolished" EXACT [PomBase:mah] is_a: FYPO:0000177 ! abnormal mitotic spindle assembly is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0090307 ! mitotic spindle assembly relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_output FYPO:0002018 ! mitotic spindle absent from cell relationship: towards GO:0090307 ! mitotic spindle assembly created_by: midori creation_date: 2012-11-02T15:04:44Z [Term] id: FYPO:0001684 name: decreased RNA level during cellular response to purvalanol A def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to purvalanol A is lower than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased mRNA level during cellular response to purvalanol A" NARROW [PomBase:mah] synonym: "decreased RNA accumulation during cellular response to purvalanol A" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to purvalanol A during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to purvalanol A during vegetative growth" EXACT [PomBase:mah] synonym: "decreased transcript level during cellular response to purvalanol A" EXACT [PomBase:vw] synonym: "reduced RNA level during cellular response to purvalanol A" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: exists_during GO:0072754 ! cellular response to purvalanol A intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:47600 ! purvalanol A relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: exists_during GO:0072754 ! cellular response to purvalanol A relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:47600 ! purvalanol A created_by: midori creation_date: 2012-11-02T15:37:15Z [Term] id: FYPO:0001685 name: increased RNA level during cellular response to purvalanol A def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to purvalanol A is higher than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased mRNA level during cellular response to purvalanol A" NARROW [PomBase:mah] synonym: "increased RNA accumulation during cellular response to purvalanol A" RELATED [PomBase:mah] synonym: "increased RNA level during cellular response to purvalanol A during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased RNA level during cellular response to purvalanol A during vegetative growth" EXACT [PomBase:mah] synonym: "increased transcript level during cellular response to purvalanol A" EXACT [PomBase:vw] is_a: FYPO:0000825 ! increased RNA level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: exists_during GO:0072754 ! cellular response to purvalanol A intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:47600 ! purvalanol A relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: exists_during GO:0072754 ! cellular response to purvalanol A relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:47600 ! purvalanol A created_by: midori creation_date: 2012-11-02T15:39:06Z [Term] id: FYPO:0001686 name: normal growth on carbendazim def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing the tubulin poison carbendazim (mecarzole; MBC)." [PomBase:mah] synonym: "normal cell population growth in presence of carbendazim" EXACT [PomBase:mah] synonym: "normal cell population growth on carbendazim" EXACT [CHEBI:3392, PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cell population growth on mecarzole" EXACT [CHEBI:3392, PomBase:al] synonym: "normal cellular response to carbendazim" RELATED [PomBase:al, PomBase:mah] synonym: "normal growth on MBC" EXACT [CHEBI:3392] synonym: "normal vegetative cell population growth on carbendazim" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:3392 ! carbendazim relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:3392 ! carbendazim created_by: midori creation_date: 2012-11-02T15:43:07Z [Term] id: FYPO:0001687 name: normal growth on benomyl def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing benomyl." [PomBase:mah] synonym: "normal cell population growth in presence of benomyl" EXACT [PomBase:mah] synonym: "normal cell population growth on benomyl" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cell population growth on methyl benzimidazole-2-yl-carbamate" EXACT [PMID:6887244] synonym: "normal cellular response to benomyl" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on benomyl" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:3015 ! benomyl relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:3015 ! benomyl created_by: midori creation_date: 2012-11-02T15:45:13Z [Term] id: FYPO:0001688 name: normal growth on brefeldin A def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing brefeldin A." [PomBase:mah] synonym: "normal cell population growth in presence of brefeldin A" EXACT [PomBase:mah] synonym: "normal cell population growth on BFA" EXACT [PomBase:mah] synonym: "normal cell population growth on brefeldin A" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to brefeldin A" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on brefeldin A" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:48080 ! brefeldin A relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:48080 ! brefeldin A created_by: midori creation_date: 2012-11-02T15:47:41Z [Term] id: FYPO:0001689 name: normal growth on 4-nitroquinoline N-oxide def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing 4-nitroquinoline N-oxide." [PomBase:mah] synonym: "normal cell population growth in presence of 4-nitroquinoline N-oxide" EXACT [PomBase:mah] synonym: "normal cell population growth on 4-nitroquinoline N-oxide" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cell population growth on 4-NQO" EXACT [PomBase:mah] synonym: "normal cell population growth on 4NQO" EXACT [PomBase:al] synonym: "normal cellular response to 4-nitroquinoline N-oxide" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on 4-nitroquinoline N-oxide" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:16907 ! 4-nitroquinoline N-oxide relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:16907 ! 4-nitroquinoline N-oxide created_by: midori creation_date: 2012-11-02T15:50:35Z [Term] id: FYPO:0001690 name: normal growth on camptothecin def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing camptothecin." [PomBase:mah] synonym: "normal cell population growth in presence of camptothecin" EXACT [PomBase:mah] synonym: "normal cell population growth on camptothecin" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cell population growth on CPT" EXACT [PomBase:al] synonym: "normal cellular response to camptothecin" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on camptothecin" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:27656 ! camptothecin relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:27656 ! camptothecin created_by: midori creation_date: 2012-11-02T15:52:52Z [Term] id: FYPO:0001691 name: normal growth on paraquat def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing paraquat." [PomBase:mah] synonym: "normal cell population growth in presence of paraquat" EXACT [PomBase:mah] synonym: "normal cell population growth on paraquat" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to paraquat" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on paraquat" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:34905 ! paraquat relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:34905 ! paraquat created_by: midori creation_date: 2012-11-02T15:54:56Z [Term] id: FYPO:0001692 name: sensitive to purvalanol A def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to purvalanol A. Cells stop growing (and may die) at a concentration of purvalanol A that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to purvalanol A" EXACT [PomBase:mah] synonym: "sensitive to purvalanol A during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to purvalanol A during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:47600 ! purvalanol A relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:47600 ! purvalanol A created_by: midori creation_date: 2012-11-02T16:20:15Z [Term] id: FYPO:0001693 name: sensitive to reversine def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to reversine. Cells stop growing (and may die) at a concentration of reversine that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to reversine" EXACT [PomBase:mah] synonym: "sensitive to reversine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to reversine during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:70723 ! reversine relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:70723 ! reversine created_by: midori creation_date: 2012-11-02T16:22:48Z [Term] id: FYPO:0001694 name: sensitive to hesperadin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to hesperadin. Cells stop growing (and may die) at a concentration of hesperadin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to hesperadin" EXACT [PomBase:mah] synonym: "sensitive to hesperadin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to hesperadin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:70726 ! hesperadin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:70726 ! hesperadin created_by: midori creation_date: 2012-11-02T16:25:02Z [Term] id: FYPO:0001695 name: sensitive to protease inhibitor def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to a protease inhibitor. Cells stop growing (and may die) at a concentration of a protease inhibitor that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to protease inhibitor" EXACT [PomBase:mah] synonym: "sensitive to protease inhibitor during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to protease inhibitor during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:37670 ! protease inhibitor relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:37670 ! protease inhibitor created_by: midori creation_date: 2012-11-02T16:28:37Z [Term] id: FYPO:0001696 name: sensitive to protein kinase inhibitor def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to a protein kinase inhibitor. Cells stop growing (and may die) at a concentration of a protein kinase inhibitor that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to protein kinase inhibitor" EXACT [PomBase:mah] synonym: "sensitive to protein kinase inhibitor during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to protein kinase inhibitor during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:37699 ! protein kinase inhibitor relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:37699 ! protein kinase inhibitor created_by: midori creation_date: 2012-11-02T16:29:18Z [Term] id: FYPO:0001697 name: sensitive to topoisomerase inhibitor def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to a topoisomerase inhibitor. Cells stop growing (and may die) at a concentration of a topoisomerase inhibitor that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to topoisomerase inhibitor" EXACT [PomBase:mah] synonym: "sensitive to topoisomerase inhibitor during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to topoisomerase inhibitor during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:70727 ! topoisomerase inhibitor relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:70727 ! topoisomerase inhibitor created_by: midori creation_date: 2012-11-02T16:36:04Z [Term] id: FYPO:0001698 name: sensitive to capsazepine def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to capsazepine. Cells stop growing (and may die) at a concentration of capsazepine that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to capsazepine" EXACT [PomBase:mah] synonym: "sensitive to capsazepine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to capsazepine during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:70773 ! capsazepine relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:70773 ! capsazepine created_by: midori creation_date: 2012-11-02T16:43:31Z [Term] id: FYPO:0001699 name: sensitive to PPT def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to 4,4',4''-(4-propylpyrazole-1,3,5-triyl)trisphenol (PPT). Cells stop growing (and may die) at a concentration of PPT that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to PPT" EXACT [PomBase:mah] synonym: "sensitive to 4,4',4''-(4-propylpyrazole-1,3,5-triyl)trisphenol" EXACT [CHEBI:64110] synonym: "sensitive to PPT during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to PPT during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:64110 ! 4,4',4''-(4-propylpyrazole-1,3,5-triyl)trisphenol relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:64110 ! 4,4',4''-(4-propylpyrazole-1,3,5-triyl)trisphenol created_by: midori creation_date: 2012-11-02T16:44:51Z [Term] id: FYPO:0001700 name: sensitive to GW 7647 def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to the receptor agonist GW 7647. Cells stop growing (and may die) at a concentration of GW 7647 that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to GW 7647" EXACT [PomBase:mah] synonym: "sensitive to GW 7647 during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to GW 7647 during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:72760 ! tryprostatin B relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:72760 ! tryprostatin B created_by: midori creation_date: 2012-11-02T16:46:27Z [Term] id: FYPO:0001701 name: sensitive to bortezomib def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to bortezomib. Cells stop growing (and may die) at a concentration of bortezomib that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to bortezomib" EXACT [PomBase:mah] synonym: "sensitive to bortezomib during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to bortezomib during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to Velcade" EXACT [CHEBI:52717] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:52717 ! bortezomib relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:52717 ! bortezomib created_by: midori creation_date: 2012-11-02T16:56:50Z [Term] id: FYPO:0001702 name: sensitive to nocodazole def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to nocodazole. Cells stop growing (and may die) at a concentration of nocodazole that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to nocodazole" EXACT [PomBase:mah] synonym: "sensitive to nocodazole during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to nocodazole during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:34892 ! nocodazole relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:34892 ! nocodazole created_by: midori creation_date: 2012-11-02T16:57:43Z [Term] id: FYPO:0001703 name: normal mitotic cell cycle checkpoint def: "A cell cycle phenotype in which a specific mitotic cell cycle checkpoint is normal (i.e. indistinguishable from wild type). A cell cycle checkpoint controls cell cycle progression by monitoring the timing and integrity of specific cell cycle events." [GO:0000075, GO:0007093, PomBase:mah] subset: qc_do_not_manually_annotate synonym: "normal cell cycle checkpoint activation" EXACT [PomBase:mah] is_a: FYPO:0000137 ! mitotic cell cycle checkpoint phenotype is_a: FYPO:0001928 ! normal regulation of mitotic cell cycle is_a: FYPO:0002741 ! normal mitotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0007093 ! mitotic cell cycle checkpoint intersection_of: qualifier PATO:0000461 ! normal relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0007093 ! mitotic cell cycle checkpoint relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-11-07T16:00:24Z [Term] id: FYPO:0001704 name: abnormal mitotic cell cycle checkpoint def: "A cell cycle phenotype in which a specific mitotic cell cycle checkpoint is abnormal. A cell cycle checkpoint normally controls cell cycle progression by monitoring the timing and integrity of specific cell cycle events. In a mutant, the checkpoint may fail to activate under appropriate conditions, or may occur to a greater or lesser extent than wild type under any specified set of conditions." [GO:0000075, GO:0007093, PomBase:mah] subset: qc_do_not_manually_annotate synonym: "abnormal mitotic cell cycle checkpoint activation" EXACT [PomBase:mah] is_a: FYPO:0000137 ! mitotic cell cycle checkpoint phenotype is_a: FYPO:0000148 ! abnormal regulation of mitotic cell cycle is_a: FYPO:0002737 ! abnormal mitotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0007093 ! mitotic cell cycle checkpoint intersection_of: qualifier PATO:0000460 ! abnormal relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0007093 ! mitotic cell cycle checkpoint relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-11-07T16:03:57Z [Term] id: FYPO:0001705 name: normal mitotic DNA damage checkpoint def: "A cell cycle checkpoint phenotype in which any mitotic DNA damage checkpoint is normal (i.e. indistinguishable from wild type). A DNA damage checkpoint normally regulates progression through the cell cycle in response to DNA damage." [PomBase:mah] synonym: "normal DNA damage checkpoint during mitotic cell cycle" EXACT [PomBase:mah] synonym: "normal mitotic DNA damage checkpoint activation" EXACT [PomBase:mah] synonym: "normal mitotic DNA damage checkpoint activation under non-stressed conditions" NARROW [PomBase:al] synonym: "normal mitotic DNA damage checkpoint during cellular response to DNA damage" EXACT [PomBase:al] synonym: "normal mitotic DNA damage checkpoint during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000968 ! normal cellular response to stress is_a: FYPO:0001703 ! normal mitotic cell cycle checkpoint intersection_of: PATO:0000001 ! quality intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0044773 ! mitotic DNA damage checkpoint intersection_of: qualifier PATO:0000461 ! normal relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0044773 ! mitotic DNA damage checkpoint relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-11-07T16:37:55Z [Term] id: FYPO:0001706 name: normal mitotic DNA damage checkpoint during cellular response to ionizing radiation def: "A cell cycle checkpoint phenotype in which any DNA damage checkpoint is normal (i.e. indistinguishable from wild type) when the cell is exposed to ionizing radiation. A DNA damage checkpoint normally regulates progression through the cell cycle in response to DNA damage." [PomBase:mah] synonym: "normal DNA damage checkpoint during cellular response to ionizing radiation during mitotic cell cycle" EXACT [PomBase:mah] synonym: "normal mitotic DNA damage checkpoint activation during cellular response to ionizing radiation" EXACT [PomBase:al] synonym: "normal mitotic DNA damage checkpoint during cellular response to gamma radiation" NARROW [PomBase:al, PomBase:mah] synonym: "normal mitotic DNA damage checkpoint during cellular response to ionizing radiation during vegetative growth" EXACT [PomBase:mah] synonym: "normal mitotic DNA damage checkpoint during gamma irradiation" NARROW [PomBase:al] is_a: FYPO:0001705 ! normal mitotic DNA damage checkpoint is_a: FYPO:0001927 ! normal cell cycle regulation during cellular response to ionizing radiation intersection_of: PATO:0000001 ! quality intersection_of: during GO:0071479 ! cellular response to ionizing radiation intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0044773 ! mitotic DNA damage checkpoint intersection_of: qualifier PATO:0000461 ! normal relationship: during GO:0071479 ! cellular response to ionizing radiation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0044773 ! mitotic DNA damage checkpoint relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-11-07T16:41:15Z [Term] id: FYPO:0001707 name: increased mitotic DNA damage checkpoint activation def: "A cell cycle checkpoint phenotype in which the incidence of mitotic cell cycle arrest or delay due to regulation by any mitotic DNA damage checkpoint is greater than in wild type under any specified set of conditions." [PomBase:mah] synonym: "increased mitotic DNA damage checkpoint activation under non-stressed conditions" NARROW [PomBase:al] is_a: FYPO:0000006 ! abnormal DNA damage checkpoint is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0044773 ! mitotic DNA damage checkpoint relationship: inheres_in GO:0044773 ! mitotic DNA damage checkpoint created_by: midori creation_date: 2012-11-07T16:53:08Z [Term] id: FYPO:0001708 name: normal iron-sulfur cluster binding def: "A molecular function phenotype in which occurrence of iron-sulfur cluster binding by a gene product (usually a protein) in a mutant is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal iron-sulphur cluster binding" EXACT [PomBase:mah] is_a: FYPO:0000706 ! normal molecular function is_a: FYPO:0001092 ! binding phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0051536 ! iron-sulfur cluster binding intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0051536 ! iron-sulfur cluster binding relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-11-08T11:12:40Z [Term] id: FYPO:0001709 name: abnormal iron-sulfur cluster binding def: "A molecular function phenotype in which occurrence of iron-sulfur cluster binding by a gene product (usually a protein) in a mutant is abnormal. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "abnormal iron-sulphur cluster binding" EXACT [PomBase:mah] is_a: FYPO:0000707 ! abnormal molecular function is_a: FYPO:0001092 ! binding phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0051536 ! iron-sulfur cluster binding intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0051536 ! iron-sulfur cluster binding relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-11-08T11:24:40Z [Term] id: FYPO:0001710 name: stabilized iron-sulfur cluster binding def: "A molecular function phenotype in which occurrence of iron-sulfur cluster binding by a gene product (usually a protein) in a mutant is stabilized, i.e. interactions between the iron-sulfur cluster and the gene product last longer than in wild type under any given set of conditions. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "increased duration of iron-sulfur cluster binding" EXACT [PomBase:mah] synonym: "stabilised iron-sulfur cluster binding" EXACT [PomBase:mah] synonym: "stabilized iron-sulphur cluster binding" EXACT [PomBase:mah] is_a: FYPO:0001709 ! abnormal iron-sulfur cluster binding is_a: PATO:0000498 ! increased duration intersection_of: PATO:0000498 ! increased duration intersection_of: inheres_in GO:0051536 ! iron-sulfur cluster binding relationship: inheres_in GO:0051536 ! iron-sulfur cluster binding created_by: midori creation_date: 2012-11-08T11:26:12Z [Term] id: FYPO:0001711 name: destabilized iron-sulfur cluster binding def: "A molecular function phenotype in which occurrence of iron-sulfur cluster binding by a gene product (usually a protein) in a mutant is stabilized, i.e. interactions between the iron-sulfur cluster and the gene product do not last as long as in wild type under any given set of conditions. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "decreased duration of iron-sulfur cluster binding" EXACT [PomBase:mah] synonym: "destabilised iron-sulfur cluster binding" EXACT [PomBase:mah] synonym: "destabilized iron-sulphur cluster binding" EXACT [PomBase:mah] is_a: FYPO:0001709 ! abnormal iron-sulfur cluster binding is_a: PATO:0000499 ! decreased duration intersection_of: PATO:0000499 ! decreased duration intersection_of: inheres_in GO:0051536 ! iron-sulfur cluster binding relationship: inheres_in GO:0051536 ! iron-sulfur cluster binding created_by: midori creation_date: 2012-11-08T11:28:03Z [Term] id: FYPO:0001712 name: coenzyme Q10 absent from cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of coenzyme Q10 measured in a cell is too low to detect." [PomBase:mah] synonym: "coenzyme Q10 absent from cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "coenzyme Q10 absent from cell during vegetative growth" EXACT [PomBase:mah] synonym: "ubiquinone 10 absent from cell" EXACT [CHEBI:46245] synonym: "UQ-10 absent from cell" EXACT [PomBase:al] is_a: FYPO:0001208 ! substance absent from cell during vegetative growth intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:46245 ! coenzyme Q10 relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:46245 ! coenzyme Q10 created_by: midori creation_date: 2012-11-08T13:08:43Z [Term] id: FYPO:0001713 name: abnormal malate import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of malate into the cell is abnormal." [PomBase:mah] synonym: "abnormal malate import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal malate import during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal malate import into cell" EXACT [PomBase:al] synonym: "abnormal malate uptake" EXACT [PomBase:mah] synonym: "abnormal malic acid import" RELATED [PomBase:al] is_a: FYPO:0001336 ! transport phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0001720 ! abnormal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0097405 ! malate import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0097405 ! malate import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-11-08T13:34:54Z [Term] id: FYPO:0001714 name: decreased malate import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of malate into the cell occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased malate import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased malate import during vegetative growth" EXACT [PomBase:mah] synonym: "decreased malate import into cell" EXACT [PomBase:al] synonym: "decreased malate uptake" EXACT [PomBase:mah] synonym: "decreased malic acid import" RELATED [PomBase:al] synonym: "reduced malate import" EXACT [PomBase:mah] is_a: FYPO:0001713 ! abnormal malate import is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0097405 ! malate import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0097405 ! malate import into cell created_by: midori creation_date: 2012-11-08T13:36:00Z [Term] id: FYPO:0001715 name: abnormal succinate import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of succinate into the cell is abnormal." [PomBase:mah] synonym: "abnormal succinate import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal succinate import during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal succinate import into cell" EXACT [PomBase:al] synonym: "abnormal succinate uptake" EXACT [PomBase:mah] synonym: "abnormal succinic acid import" RELATED [PomBase:al] is_a: FYPO:0001336 ! transport phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0001720 ! abnormal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0097404 ! succinate import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0097404 ! succinate import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-11-08T13:37:16Z [Term] id: FYPO:0001716 name: decreased succinate import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of succinate into the cell occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased succinate import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased succinate import during vegetative growth" EXACT [PomBase:mah] synonym: "decreased succinate import into cell" EXACT [PomBase:al] synonym: "decreased succinate uptake" EXACT [PomBase:mah] synonym: "decreased succinic acid import" RELATED [PomBase:al] synonym: "reduced succinate import" EXACT [PomBase:mah] is_a: FYPO:0001715 ! abnormal succinate import is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0097404 ! succinate import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0097404 ! succinate import into cell created_by: midori creation_date: 2012-11-08T13:37:23Z [Term] id: FYPO:0001717 name: abnormal malonic acid import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of malonic acid into the cell is abnormal." [PomBase:mah] synonym: "abnormal malonate import" RELATED [PomBase:mah] synonym: "abnormal malonic acid import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal malonic acid import during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal malonic acid import into cell" EXACT [PomBase:al] synonym: "abnormal malonic acid uptake" EXACT [PomBase:mah] is_a: FYPO:0001336 ! transport phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0001720 ! abnormal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0097406 ! malonic acid import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0097406 ! malonic acid import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-11-08T13:39:26Z [Term] id: FYPO:0001718 name: decreased malonic acid import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of malonic acid into the cell occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased malonate import" RELATED [PomBase:mah] synonym: "decreased malonic acid import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased malonic acid import during vegetative growth" EXACT [PomBase:mah] synonym: "decreased malonic acid import into cell" EXACT [PomBase:al] synonym: "decreased malonic acid uptake" EXACT [PomBase:mah] synonym: "reduced malonic acid import" EXACT [PomBase:mah] is_a: FYPO:0001717 ! abnormal malonic acid import is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0097406 ! malonic acid import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0097406 ! malonic acid import into cell created_by: midori creation_date: 2012-11-08T13:39:31Z [Term] id: FYPO:0001719 name: sensitive to lithium def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to lithium ions. Cells stop growing (and may die) at a concentration of lithium ions that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to lithium" EXACT [PomBase:mah] synonym: "sensitive to lithium during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to lithium during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to lithium ions" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:49713 ! lithium(1+) relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:49713 ! lithium(1+) created_by: midori creation_date: 2012-11-08T13:56:37Z [Term] id: FYPO:0001720 name: abnormal transport def: "A phenotype in which a specific transport process is abnormal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate is_a: FYPO:0000149 ! transport phenotype is_a: FYPO:0000628 ! abnormal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0006810 ! transport intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0006810 ! transport relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-11-08T14:01:10Z [Term] id: FYPO:0001721 name: abnormal sodium export def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the export of sodium ions out of a cell or organelle is abnormal." [PomBase:mah] synonym: "abnormal cellular sodium export" EXACT [PomBase:al] synonym: "abnormal sodium export during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal sodium export during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal sodium export from cell" NARROW [PomBase:mah] synonym: "abnormal sodium ion export" EXACT [PomBase:mah] is_a: FYPO:0001336 ! transport phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0001720 ! abnormal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0071436 ! sodium ion export intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0071436 ! sodium ion export relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-11-08T14:14:05Z [Term] id: FYPO:0001722 name: decreased sodium export def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the export of sodium ions out of a cell or organelle occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased cellular sodium export" EXACT [PomBase:al] synonym: "decreased sodium export during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased sodium export during vegetative growth" EXACT [PomBase:mah] synonym: "decreased sodium export from cell" NARROW [PomBase:mah] synonym: "decreased sodium ion export" EXACT [PomBase:mah] synonym: "reduced sodium export" EXACT [PomBase:mah] is_a: FYPO:0001721 ! abnormal sodium export is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071436 ! sodium ion export relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071436 ! sodium ion export created_by: midori creation_date: 2012-11-08T14:16:42Z [Term] id: FYPO:0001723 name: ferrichrome absent from cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more ferrichromes measured in a cell is too low to detect." [PomBase:mah] synonym: "ferrichrome absent from cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "ferrichrome absent from cell during vegetative growth" EXACT [PomBase:mah] synonym: "siderophore absent from cell" BROAD [PomBase:al] is_a: FYPO:0001208 ! substance absent from cell during vegetative growth intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:61414 ! ferrichromes relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:61414 ! ferrichromes created_by: midori creation_date: 2012-11-08T14:29:13Z [Term] id: FYPO:0001724 name: increased GTP binding def: "A molecular function phenotype in which occurrence of GTP binding by a gene product (usually a protein) in a mutant is increased. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] comment: This term can mean that the mutated gene product itself binds GTP more than wild type, or that a mutation in one gene increases GTP binding by a second gene product. When using this term, it is therefore recommended to note the specific protein(s) affected. is_a: FYPO:0001528 ! abnormal GTP binding is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0005525 ! GTP binding relationship: inheres_in GO:0005525 ! GTP binding created_by: midori creation_date: 2012-11-08T14:35:53Z [Term] id: FYPO:0001725 name: normal cellular aspartate level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-aspartate measured in the cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular aspartate level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular aspartate level during vegetative growth" EXACT [PomBase:mah] synonym: "normal cellular aspartic acid level" RELATED [PomBase:mah] synonym: "normal cellular L-aspartate level" EXACT [PomBase:mah] synonym: "normal level of aspartate in cell" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:29993 ! L-aspartate(2-) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:29993 ! L-aspartate(2-) created_by: midori creation_date: 2012-11-08T15:11:15Z [Term] id: FYPO:0001726 name: normal cellular cysteine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-cysteine measured in the cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular cysteine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular cysteine level during vegetative growth" EXACT [PomBase:mah] synonym: "normal cellular L-cysteine level" EXACT [PomBase:mah] synonym: "normal level of cysteine in cell" EXACT [PomBase:mah] is_a: FYPO:0001544 ! normal cellular sulfur level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:17561 ! L-cysteine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:17561 ! L-cysteine created_by: midori creation_date: 2012-11-08T15:15:16Z [Term] id: FYPO:0001727 name: decreased cellular glutamine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-glutamine measured in the cell is lower than normal." [PomBase:mah] synonym: "decreased cellular glutamine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular glutamine level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased cellular L-glutamine level" EXACT [PomBase:mah] synonym: "decreased level of glutamine in cell" EXACT [PomBase:mah] synonym: "reduced cellular glutamine level" EXACT [PomBase:mah] synonym: "reduced level of glutamine in cell" EXACT [PomBase:mah] is_a: FYPO:0003985 ! decreased cellular amino acid level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:18050 ! L-glutamine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:18050 ! L-glutamine created_by: midori creation_date: 2012-11-08T15:16:02Z [Term] id: FYPO:0001728 name: increased cellular serine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-serine measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular L-serine level" EXACT [CHEBI:16856, PomBase:al] synonym: "increased cellular serine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular serine level during vegetative growth" EXACT [PomBase:mah] synonym: "increased serine accumulation" RELATED [PomBase:mah] is_a: FYPO:0003986 ! increased cellular amino acid level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:17115 ! L-serine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:17115 ! L-serine created_by: midori creation_date: 2012-11-08T15:31:11Z [Term] id: FYPO:0001729 name: normal vacuolar cysteine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-cysteine measured in the vacuole is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal level of cysteine in vacuole" EXACT [PomBase:mah] synonym: "normal vacuolar cysteine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal vacuolar cysteine level during vegetative growth" EXACT [PomBase:mah] synonym: "normal vacuolar L-cysteine level" EXACT [PomBase:mah] is_a: FYPO:0001603 ! normal level of substance in vacuole is_a: FYPO:0001726 ! normal cellular cysteine level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:17561 ! L-cysteine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:17561 ! L-cysteine created_by: midori creation_date: 2012-11-08T15:32:07Z [Term] id: FYPO:0001730 name: increased level of substance in vacuole def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of a specific substance measured in the vacuole is higher than normal." [PomBase:mah] synonym: "increased level of substance in vacuole during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased level of substance in vacuole during vegetative growth" EXACT [PomBase:mah] synonym: "increased vacuolar level of substance" EXACT [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth is_a: FYPO:0001601 ! altered level of substance in vacuole intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: towards CHEBI:24431 ! chemical entity relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: towards CHEBI:24431 ! chemical entity created_by: midori creation_date: 2012-11-08T15:33:48Z [Term] id: FYPO:0001731 name: increased vacuolar glutamate level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-glutamate measured in the vacuole is higher than normal." [PomBase:mah] synonym: "increased level of glutamate in vacuole" EXACT [PomBase:mah] synonym: "increased vacuolar glutamate level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased vacuolar glutamate level during vegetative growth" EXACT [PomBase:mah] synonym: "increased vacuolar glutamic acid level" RELATED [PomBase:mah] synonym: "increased vacuolar L-glutamate level" EXACT [PomBase:mah] is_a: FYPO:0001568 ! increased cellular glutamate level is_a: FYPO:0001730 ! increased level of substance in vacuole intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: towards CHEBI:29989 ! D-glutamate(2-) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: towards CHEBI:29989 ! D-glutamate(2-) created_by: midori creation_date: 2012-11-08T15:35:05Z [Term] id: FYPO:0001732 name: decreased vacuolar glutamine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-glutamine measured in the vacuole is lower than normal." [PomBase:mah] synonym: "decreased level of glutamine in vacuole" EXACT [PomBase:mah] synonym: "decreased vacuolar glutamine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased vacuolar glutamine level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased vacuolar L-glutamine level" EXACT [PomBase:mah] synonym: "reduced level of glutamine in vacuole" EXACT [PomBase:mah] synonym: "reduced vacuolar glutamine level" EXACT [PomBase:mah] is_a: FYPO:0001602 ! decreased level of substance in vacuole is_a: FYPO:0001727 ! decreased cellular glutamine level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: towards CHEBI:18050 ! L-glutamine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: towards CHEBI:18050 ! L-glutamine created_by: midori creation_date: 2012-11-08T15:38:07Z [Term] id: FYPO:0001733 name: abnormal spindle pole body separation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which spindle pole body separation is abnormal. Spindle pole body separation is the process in which duplicated spindle pole bodies detach and migrate apart within the nuclear membrane." [PomBase:mah] comment: Also consider annotating to 'monopolar mitotic spindle' (FYPO:0000276) if you observe any monopolar spindles. synonym: "abnormal SPB separation" EXACT [PomBase:mah] synonym: "abnormal spindle pole body separation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal spindle pole body separation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0002734 ! abnormal cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000073 ! spindle pole body separation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000073 ! spindle pole body separation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-11-14T11:49:37Z [Term] id: FYPO:0001734 name: abolished spindle pole body separation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which duplicated spindle pole bodies do not separate." [PomBase:mah] comment: Also consider annotating to 'monopolar mitotic spindle' (FYPO:0000276) if you observe any monopolar spindles. synonym: "abolished spindle pole body separation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "clustered spindle pole bodies" RELATED [PomBase:al] synonym: "SPB separation abolished" EXACT [PomBase:mah] synonym: "spindle pole body separation abolished" EXACT [PomBase:mah] synonym: "spindle pole body separation abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001733 ! abnormal spindle pole body separation is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0000073 ! spindle pole body separation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0000073 ! spindle pole body separation created_by: midori creation_date: 2012-11-14T11:49:54Z [Term] id: FYPO:0001735 name: abnormal iron-sulfur cluster transfer def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the movement of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein is abnormal." [PomBase:mah] synonym: "abnormal iron-sulfur cluster transfer during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal iron-sulfur cluster transfer during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal iron-sulphur cluster transfer" EXACT [PomBase:mah] is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0097428 ! protein maturation by iron-sulfur cluster transfer intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0097428 ! protein maturation by iron-sulfur cluster transfer relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-11-14T12:03:16Z [Term] id: FYPO:0001736 name: decreased iron-sulfur cluster transfer def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the movement of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased iron-sulfur cluster transfer during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased iron-sulfur cluster transfer during vegetative growth" EXACT [PomBase:mah] synonym: "decreased iron-sulfur cluster transfer to ferredoxin" NARROW [PomBase:al] synonym: "decreased iron-sulphur cluster transfer" EXACT [PomBase:mah] synonym: "reduced iron-sulfur cluster transfer" EXACT [PomBase:mah] is_a: FYPO:0001735 ! abnormal iron-sulfur cluster transfer is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0097428 ! protein maturation by iron-sulfur cluster transfer relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0097428 ! protein maturation by iron-sulfur cluster transfer created_by: midori creation_date: 2012-11-14T12:03:45Z [Term] id: FYPO:0001737 name: abnormal pantothenate import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of pantothenate into the cell is abnormal." [PomBase:mah] synonym: "abnormal pantothenate import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal pantothenate import during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal pantothenate import into cell" EXACT [PomBase:al] synonym: "abnormal pantothenate uptake" EXACT [PomBase:mah] synonym: "abnormal pantothenic acid import" RELATED [PomBase:al] is_a: FYPO:0001336 ! transport phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0001720 ! abnormal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0044755 ! pantothenate import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0044755 ! pantothenate import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-11-14T12:23:05Z [Term] id: FYPO:0001738 name: decreased pantothenate import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of pantothenate into the cell occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased pantothenate import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased pantothenate import during vegetative growth" EXACT [PomBase:mah] synonym: "decreased pantothenate import into cell" EXACT [PomBase:al] synonym: "decreased pantothenate uptake" EXACT [PomBase:mah] synonym: "decreased pantothenic acid import" RELATED [PomBase:al] synonym: "reduced pantothenate import" EXACT [PomBase:mah] is_a: FYPO:0001737 ! abnormal pantothenate import is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0044755 ! pantothenate import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0044755 ! pantothenate import into cell created_by: midori creation_date: 2012-11-14T12:23:13Z [Term] id: FYPO:0001739 name: increased pantothenate import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of pantothenate into the cell occurs to a greater extent than normal." [PomBase:mah] synonym: "increased pantothenate import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased pantothenate import during vegetative growth" EXACT [PomBase:mah] synonym: "increased pantothenate import into cell" EXACT [PomBase:al] synonym: "increased pantothenate uptake" EXACT [PomBase:mah] synonym: "increased pantothenic acid import" RELATED [PomBase:al] is_a: FYPO:0001737 ! abnormal pantothenate import is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0044755 ! pantothenate import into cell intersection_of: inheres_in GO:0044755 ! pantothenate import into cell relationship: happens_during GO:0044755 ! pantothenate import into cell relationship: inheres_in GO:0044755 ! pantothenate import into cell created_by: midori creation_date: 2012-11-14T12:23:34Z [Term] id: FYPO:0001740 name: increased gross chromosomal rearrangement def: "A cell phenotype in which large chromosomal rearrangements occur more frequently than in wild type cells. Chromosomal rearrangements may include deletions, duplications, inversions, and translocations." [http://www.ncbi.nlm.nih.gov/books/NBK21367/, PMID:18923422, PomBase:mah] synonym: "increased occurrence of gross chromosomal rearrangement" EXACT [PomBase:mah] is_a: FYPO:0000641 ! abnormal chromosome organization created_by: midori creation_date: 2012-11-14T13:36:27Z [Term] id: FYPO:0001741 name: increased chromosomal translocation def: "A cell phenotype in which chromosomal translocations occur more frequently than in wild type cells. In a chromosomal translocation, chromosome parts are exchanged between non-homologous chromosomes." [PMID:18923422, PomBase:al, PomBase:mah] synonym: "increased occurrence of chromosomal translocation" EXACT [PomBase:mah] is_a: FYPO:0001740 ! increased gross chromosomal rearrangement created_by: midori creation_date: 2012-11-14T14:01:18Z [Term] id: FYPO:0001742 name: increased isochromosome formation def: "A cell phenotype in which isochromosome formation occurs more frequently than in wild type cells. In isochromosome formation, one chromosome arm is lost and the other arm is duplicated in its place." [PMID:18923422, PomBase:al, PomBase:mah] comment: In S. pombe, isochromosome formation is most commonly observed with chromosome 3. synonym: "increased occurrence of isochromosome formation" EXACT [PomBase:mah] is_a: FYPO:0001740 ! increased gross chromosomal rearrangement created_by: midori creation_date: 2012-11-14T14:05:03Z [Term] id: FYPO:0001743 name: increased isochromosome formation with preferential breakage in the imr region def: "A cell phenotype in which isochromosome formation occurs more frequently than in wild type cells, and in which the break point is located in the imr region in the majority of cases. In isochromosome formation, one chromosome arm is lost and the other arm is duplicated in its place." [PMID:18923422, PomBase:al, PomBase:mah] comment: In S. pombe, isochromosome formation is most commonly observed with chromosome 3. When wild type cells form isochromosomes, the break-point is formed half the time in the imr region and half the time in the otr-irc region. synonym: "increased occurrence of isochromosome formation with preferential breakage in the imr region" EXACT [PomBase:mah] is_a: FYPO:0001742 ! increased isochromosome formation created_by: midori creation_date: 2012-11-14T14:11:30Z [Term] id: FYPO:0001744 name: abnormal biotin import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of biotin into the cell is abnormal." [PomBase:mah] synonym: "abnormal biotin import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal biotin import during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal biotin import into cell" EXACT [PomBase:al] synonym: "abnormal biotin uptake" EXACT [PomBase:mah] is_a: FYPO:0001336 ! transport phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0001720 ! abnormal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0044756 ! biotin import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0044756 ! biotin import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-11-14T14:16:45Z [Term] id: FYPO:0001745 name: increased biotin import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of biotin into the cell occurs to a greater extent than normal." [PomBase:mah] synonym: "increased biotin import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased biotin import during vegetative growth" EXACT [PomBase:mah] synonym: "increased biotin import into cell" EXACT [PomBase:al] synonym: "increased biotin uptake" EXACT [PomBase:mah] is_a: FYPO:0001744 ! abnormal biotin import is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0044756 ! biotin import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0044756 ! biotin import into cell created_by: midori creation_date: 2012-11-14T14:17:14Z [Term] id: FYPO:0001746 name: abolished biotin import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of biotin into the cell is abolished." [PomBase:mah] synonym: "abolished biotin import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished biotin import during vegetative growth" EXACT [PomBase:mah] synonym: "abolished biotin import into cell" EXACT [PomBase:al] synonym: "abolished biotin uptake" EXACT [PomBase:mah] synonym: "absent biotin import" EXACT [PomBase:al] synonym: "biotin import abolished" EXACT [PomBase:mah] is_a: FYPO:0001744 ! abnormal biotin import is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0044756 ! biotin import into cell relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0044756 ! biotin import into cell created_by: midori creation_date: 2012-11-14T14:17:27Z [Term] id: FYPO:0001747 name: abnormal nickel import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of nickel ions into a cell is abnormal." [PomBase:mah] synonym: "abnormal cellular nickel import" EXACT [PomBase:al] synonym: "abnormal nickel cation import" EXACT [PomBase:mah] synonym: "abnormal nickel import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal nickel import during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal nickel import into cell" EXACT [PomBase:mah] is_a: FYPO:0001336 ! transport phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0001720 ! abnormal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0090509 ! nickel cation import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0090509 ! nickel cation import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-11-14T14:26:34Z [Term] id: FYPO:0001748 name: decreased nickel import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of nickel ions into a cell occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased cellular nickel import" EXACT [PomBase:al] synonym: "decreased nickel cation import" EXACT [PomBase:mah] synonym: "decreased nickel import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased nickel import during vegetative growth" EXACT [PomBase:mah] synonym: "decreased nickel import into cell" EXACT [PomBase:mah] synonym: "reduced nickel import" EXACT [PomBase:mah] is_a: FYPO:0001747 ! abnormal nickel import is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0090509 ! nickel cation import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0090509 ! nickel cation import into cell created_by: midori creation_date: 2012-11-14T14:26:41Z [Term] id: FYPO:0001749 name: sensitive to tacrolimus during salt stress def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to tacrolimus when the cell is subject to salt stress." [PomBase:mah] synonym: "hypersensitive to tacrolimus during salt stress" EXACT [PomBase:mah] synonym: "sensitive to FK506 during salt stress" EXACT [CHEBI:61057, PomBase:mah] synonym: "sensitive to tacrolimus during salt stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to tacrolimus during salt stress during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000086 ! sensitive to tacrolimus intersection_of: FYPO:0000086 ! sensitive to tacrolimus intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: during GO:0071472 ! cellular response to salt stress intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:61057 ! tacrolimus hydrate relationship: during GO:0071472 ! cellular response to salt stress relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:61057 ! tacrolimus hydrate created_by: midori creation_date: 2012-11-14T14:38:07Z [Term] id: FYPO:0001750 name: abnormal homocitrate synthase activity def: "A molecular function phenotype in which the observed rate of homocitrate synthase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004410 ! homocitrate synthase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004410 ! homocitrate synthase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-11-14T14:42:55Z [Term] id: FYPO:0001751 name: increased homocitrate synthase activity def: "A molecular function phenotype in which the observed rate of homocitrate synthase activity is increased." [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0001750 ! abnormal homocitrate synthase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0004410 ! homocitrate synthase activity relationship: inheres_in GO:0004410 ! homocitrate synthase activity created_by: midori creation_date: 2012-11-14T14:43:03Z [Term] id: FYPO:0001752 name: decreased homocitrate synthase activity def: "A molecular function phenotype in which the observed rate of homocitrate synthase activity is decreased." [PomBase:mah] synonym: "reduced homocitrate synthase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0001750 ! abnormal homocitrate synthase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004410 ! homocitrate synthase activity relationship: inheres_in GO:0004410 ! homocitrate synthase activity created_by: midori creation_date: 2012-11-14T14:45:33Z [Term] id: FYPO:0001753 name: normal anaerobic cell population growth def: "A cell population phenotype in which a population of cells grow normally under anaerobic conditions." [PomBase:mah] synonym: "normal anaerobic growth" BROAD [PomBase:mah] is_a: FYPO:0000047 ! normal cell population growth created_by: midori creation_date: 2012-11-14T14:52:46Z [Term] id: FYPO:0001754 name: growth auxotrophic for lysine and methionine def: "Auxotrophy in which a cell is unable to synthesize lysine or methionine, and therefore requires lysine and methionine in the medium for vegetative cell growth." [PomBase:mah] synonym: "growth auxotrophic for lysine and methionine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "growth auxotrophic for lysine and methionine during vegetative growth" EXACT [PomBase:mah] synonym: "lysine and methionine auxotrophy" EXACT [PomBase:mah] is_a: FYPO:0000039 ! growth auxotrophic for lysine is_a: FYPO:0000040 ! growth auxotrophic for methionine intersection_of: PATO:0000422 ! auxotrophic intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:16643 ! L-methionine intersection_of: towards CHEBI:18019 ! L-lysine relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:16643 ! L-methionine relationship: towards CHEBI:18019 ! L-lysine created_by: midori creation_date: 2012-11-14T14:54:20Z [Term] id: FYPO:0001755 name: growth auxotrophic for lysine and cysteine def: "Auxotrophy in which a cell is unable to synthesize lysine or cysteine, and therefore requires lysine and cysteine in the medium for vegetative cell growth." [PomBase:mah] synonym: "growth auxotrophic for lysine and cysteine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "growth auxotrophic for lysine and cysteine during vegetative growth" EXACT [PomBase:mah] synonym: "lysine and cysteine auxotrophy" EXACT [PomBase:mah] is_a: FYPO:0000037 ! growth auxotrophic for cysteine is_a: FYPO:0000039 ! growth auxotrophic for lysine intersection_of: PATO:0000422 ! auxotrophic intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:17561 ! L-cysteine intersection_of: towards CHEBI:18019 ! L-lysine relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:17561 ! L-cysteine relationship: towards CHEBI:18019 ! L-lysine created_by: midori creation_date: 2012-11-14T14:55:06Z [Term] id: FYPO:0001756 name: abnormal protein phosphatase activity def: "A molecular function phenotype in which the observed rate of protein phosphatase activity is abnormal." [PomBase:mah] synonym: "abnormal phosphoprotein phosphatase activity" EXACT [GO:0004721, PomBase:mah] is_a: FYPO:0004302 ! abnormal phosphatase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004721 ! phosphoprotein phosphatase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004721 ! phosphoprotein phosphatase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-11-14T15:02:25Z [Term] id: FYPO:0001757 name: decreased protein phosphatase activity def: "A molecular function phenotype in which the observed rate of a protein phosphatase activity is decreased." [PomBase:mah] synonym: "decreased phosphoprotein phosphatase activity" EXACT [GO:0004721, PomBase:mah] synonym: "reduced protein phosphatase activity" EXACT [PomBase:mah] is_a: FYPO:0001756 ! abnormal protein phosphatase activity is_a: FYPO:0004304 ! decreased phosphatase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004721 ! phosphoprotein phosphatase activity relationship: inheres_in GO:0004721 ! phosphoprotein phosphatase activity created_by: midori creation_date: 2012-11-14T15:02:37Z [Term] id: FYPO:0001758 name: increased protein phosphatase activity def: "A molecular function phenotype in which the observed rate of a protein phosphatase activity is increased." [PomBase:mah] synonym: "increased phosphoprotein phosphatase activity" EXACT [GO:0004721, PomBase:mah] is_a: FYPO:0001756 ! abnormal protein phosphatase activity is_a: FYPO:0004415 ! increased phosphatase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0004721 ! phosphoprotein phosphatase activity relationship: inheres_in GO:0004721 ! phosphoprotein phosphatase activity created_by: midori creation_date: 2012-11-14T15:02:48Z [Term] id: FYPO:0001759 name: normal protein phosphatase activity def: "A molecular function phenotype in which the observed rate of a protein phosphatase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal phosphoprotein phosphatase activity" EXACT [GO:0004721] is_a: FYPO:0004469 ! normal phosphatase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004721 ! phosphoprotein phosphatase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0004721 ! phosphoprotein phosphatase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-11-14T15:03:21Z [Term] id: FYPO:0001760 name: normal cell separation after cytokinesis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which cell separation after cytokinesis is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cell separation after cytokinesis during vegetative growth" EXACT [PomBase:mah] synonym: "normal cell separation after cytokinesis following mitosis" EXACT [PomBase:mah] synonym: "normal mitotic cytokinetic cell separation" EXACT [GO:0000920, PomBase:mah] is_a: FYPO:0001319 ! normal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000920 ! cell separation after cytokinesis intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000920 ! cell separation after cytokinesis relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-11-14T15:25:43Z [Term] id: FYPO:0001761 name: normal mitotic G1/S phase transition def: "A cellular process phenotype in which the G1/S transition of the mitotic cell cycle is normal." [PomBase:mah] synonym: "normal cell cycle progression through mitotic G1/S phase transition" EXACT [PomBase:mah] synonym: "normal mitotic G1/S phase transition during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002741 ! normal mitotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000082 ! G1/S transition of mitotic cell cycle intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000082 ! G1/S transition of mitotic cell cycle relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-11-14T15:28:02Z [Term] id: FYPO:0001762 name: normal tRNA modification def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which tRNA modification, the covalent alteration of one or more nucleotides within a tRNA molecule, is normal (i.e. indistinguishable from wild type)." [GO:0006400, PomBase:mah] synonym: "normal tRNA modification during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal tRNA modification during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001980 ! normal RNA processing intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006400 ! tRNA modification intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006400 ! tRNA modification relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-11-14T17:09:21Z [Term] id: FYPO:0001763 name: normal tRNA methylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which tRNA methylation, the posttranscriptional addition of methyl groups to specific residues in a tRNA molecule, is normal (i.e. indistinguishable from wild type)." [GO:0030488, PomBase:mah] synonym: "normal tRNA methylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal tRNA methylation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001762 ! normal tRNA modification intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0030488 ! tRNA methylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0030488 ! tRNA methylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-11-14T17:11:06Z [Term] id: FYPO:0001764 name: normal tRNA-Asp C48, C49, C60, C61 and C62 methylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the posttranscriptional addition of methyl groups to the C48, C49, C60, C61 and C62 residues in a tRNA-Asp molecule, is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal tRNA-Asp C48, C49, C60, C61 and C62 methylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal tRNA-Asp C48, C49, C60, C61 and C62 methylation during vegetative growth" EXACT [PomBase:mah] synonym: "normal tRNA-Asp methylation on C48, C49, C60, C61 and C62" EXACT [PomBase:mah] is_a: FYPO:0001763 ! normal tRNA methylation created_by: midori creation_date: 2012-11-14T17:12:31Z [Term] id: FYPO:0001765 name: abnormal tRNA modification def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which tRNA modification, the covalent alteration of one or more nucleotides within a tRNA molecule, is abnormal." [GO:0006400, PomBase:mah] synonym: "abnormal tRNA modification during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal tRNA modification during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000370 ! abnormal RNA modification is_a: FYPO:0001554 ! abnormal tRNA processing intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006400 ! tRNA modification intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006400 ! tRNA modification relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-11-14T17:16:05Z [Term] id: FYPO:0001766 name: abnormal tRNA methylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which tRNA methylation, the posttranscriptional addition of methyl groups to specific residues in a tRNA molecule, is abnormal." [GO:0030488, PomBase:mah] synonym: "abnormal tRNA methylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal tRNA methylation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001765 ! abnormal tRNA modification intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0030488 ! tRNA methylation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0030488 ! tRNA methylation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-11-14T17:16:35Z [Term] id: FYPO:0001767 name: decreased tRNA-Asp C48, C49, C60, C61 and C62 methylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the posttranscriptional addition of methyl groups to the C48, C49, C60, C61 and C62 residues in a tRNA-Asp molecule, occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased tRNA-Asp C48, C49, C60, C61 and C62 methylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased tRNA-Asp C48, C49, C60, C61 and C62 methylation during vegetative growth" EXACT [PomBase:mah] synonym: "decreased tRNA-Asp methylation on C48, C49, C60, C61 and C62" EXACT [PomBase:mah] synonym: "reduced tRNA-Asp C48, C49, C60, C61 and C62 methylation" EXACT [PomBase:mah] is_a: FYPO:0001766 ! abnormal tRNA methylation created_by: midori creation_date: 2012-11-14T17:17:12Z [Term] id: FYPO:0001768 name: abolished tRNA-Asp C38 methylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the posttranscriptional addition of methyl groups to the C38 residue in a tRNA-Asp molecule is abolished." [PomBase:mah] synonym: "abolished tRNA-Asp C38 methylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished tRNA-Asp C38 methylation during vegetative growth" EXACT [PomBase:mah] synonym: "abolished tRNA-Asp methylation on C38" EXACT [PomBase:mah] synonym: "tRNA-Asp C38 methylation abolished" EXACT [PomBase:mah] is_a: FYPO:0000371 ! abolished RNA modification is_a: FYPO:0001766 ! abnormal tRNA methylation created_by: midori creation_date: 2012-11-14T17:18:18Z [Term] id: FYPO:0001769 name: increased tRNA-Asp C38 methylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the posttranscriptional addition of methyl groups to the C38 residue in a tRNA-Asp molecule, occurs to a greater extent than normal." [PomBase:mah] synonym: "increased tRNA-Asp C38 methylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased tRNA-Asp C38 methylation during vegetative growth" EXACT [PomBase:mah] synonym: "increased tRNA-Asp methylation on C38" EXACT [PomBase:mah] is_a: FYPO:0001766 ! abnormal tRNA methylation created_by: midori creation_date: 2012-11-14T17:21:25Z [Term] id: FYPO:0001770 name: normal tRNA methyltransferase activity def: "A molecular function phenotype in which the observed rate of a tRNA methyltransferase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0008175 ! tRNA methyltransferase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0008175 ! tRNA methyltransferase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-11-14T17:30:11Z [Term] id: FYPO:0001771 name: abnormal tRNA methyltransferase activity def: "A molecular function phenotype in which the observed rate of a tRNA methyltransferase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0008175 ! tRNA methyltransferase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0008175 ! tRNA methyltransferase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-11-14T17:31:31Z [Term] id: FYPO:0001772 name: decreased tRNA methyltransferase activity def: "A molecular function phenotype in which the observed rate of a tRNA methyltransferase activity is decreased." [PomBase:mah] synonym: "reduced tRNA methyltransferase activity" EXACT [PomBase:al] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0001771 ! abnormal tRNA methyltransferase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0008175 ! tRNA methyltransferase activity relationship: inheres_in GO:0008175 ! tRNA methyltransferase activity created_by: midori creation_date: 2012-11-14T17:31:42Z [Term] id: FYPO:0001773 name: abolished tRNA methyltransferase activity def: "A molecular function phenotype in which a tRNA methyltransferase activity is absent." [PomBase:mah] synonym: "tRNA methyltransferase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0001771 ! abnormal tRNA methyltransferase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0008175 ! tRNA methyltransferase activity relationship: towards GO:0008175 ! tRNA methyltransferase activity created_by: midori creation_date: 2012-11-14T17:31:46Z [Term] id: FYPO:0001774 name: abnormal protein localization to eisosome filament def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the eisosome filament is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found in the eisosome filament and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to eisosome filament" EXACT [PomBase:mah] synonym: "abnormal protein localization to eisosome filament during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein localization to eisosome filament during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal protein localization to linear eisosome" EXACT [PomBase:mah] is_a: FYPO:0000928 ! abnormal protein localization to cell cortex intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0097446 ! protein localization to eisosome filament intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0097446 ! protein localization to eisosome filament relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-11-21T13:53:15Z [Term] id: FYPO:0001775 name: abolished protein localization to eisosome filament def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the eisosome filament is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to eisosome filament" EXACT [PomBase:mah] synonym: "abolished protein localization to eisosome filament during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to eisosome filament during vegetative growth" EXACT [PomBase:mah] synonym: "abolished protein localization to linear eisosome" EXACT [PomBase:mah] synonym: "protein localization to eisosome filament abolished" EXACT [PomBase:mah] is_a: FYPO:0000930 ! abolished protein localization to cell cortex is_a: FYPO:0001774 ! abnormal protein localization to eisosome filament intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0097446 ! protein localization to eisosome filament relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0097446 ! protein localization to eisosome filament created_by: midori creation_date: 2012-11-21T13:55:52Z [Term] id: FYPO:0001776 name: normal protein localization to eisosome filament def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the eisosome filament is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to eisosome filament" EXACT [PomBase:mah] synonym: "normal protein localization to eisosome filament during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to eisosome filament during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein localization to linear eisosome" EXACT [PomBase:mah] is_a: FYPO:0001402 ! normal protein localization to cell cortex is_a: FYPO:0003184 ! normal protein localization to cytoskeleton during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0097446 ! protein localization to eisosome filament intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0097446 ! protein localization to eisosome filament relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-11-21T14:04:30Z [Term] id: FYPO:0001777 name: short eisosome filament def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the eisosome filament is shorter than normal." [PomBase:mah] synonym: "short eisosome filament during mitotic cell cycle" RELATED [PomBase:mah] synonym: "short eisosome filament during vegetative growth" EXACT [PomBase:mah] synonym: "short linear eisosomes" EXACT [PomBase:al] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: PATO:0000574 ! decreased length intersection_of: PATO:0000574 ! decreased length intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0036286 ! eisosome filament relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0036286 ! eisosome filament created_by: midori creation_date: 2012-11-21T14:05:30Z [Term] id: FYPO:0001778 name: abnormal centromere localization def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of one or more centromere(s) is abnormal." [PomBase:mah] synonym: "abnormal centromere localisation" EXACT [PomBase:mah] synonym: "abnormal centromere localization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal centromere localization during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal kinetochore localization" EXACT [GO:0072765, PomBase:al] is_a: FYPO:0000443 ! abnormal protein localization during vegetative growth is_a: FYPO:0001440 ! abnormal protein complex localization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0072765 ! centromere localization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0072765 ! centromere localization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-11-21T14:24:28Z [Term] id: FYPO:0001779 name: abnormal centromere clustering at nuclear periphery alt_id: FYPO:0001780 def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of centromeres and associated kinetochores into a cluster at the nuclear periphery is abnormal. Centromere-kinetochore complexes normally cluster near the old spindle pole body during interphase of the mitotic cell cycle." [PomBase:mah] synonym: "abnormal centromere clustering at nuclear periphery during interphase of mitotic cell cycle" EXACT [PomBase:mah] synonym: "abnormal centromere clustering at nuclear periphery during mitotic cell cycle" EXACT [PomBase:mah] synonym: "abnormal centromere clustering at nuclear periphery during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal centromere clustering at old mitotic spindle pole body" RELATED [PomBase:vw] synonym: "abnormal centromere clustering at SPB" RELATED [PomBase:mah] synonym: "abnormal centromere clustering at spindle pole body" RELATED [GO:0072766, PomBase:mah] synonym: "abnormal centromere-SPB clustering" RELATED [GO:0072766] synonym: "abnormal kinetochore clustering at old mitotic spindle pole body" RELATED [PomBase:vw] synonym: "abnormal kinetochore clustering at SPB" RELATED [GO:0072766] synonym: "abnormal kinetochore clustering at spindle pole body" RELATED [PomBase:mah] synonym: "abnormal kinetochore localization at spindle pole body" RELATED [GO:0072766] synonym: "abnormal kinetochores to spindle pole body clustering" RELATED [PomBase:vw] synonym: "mislocalized, scattered centromeres" RELATED [PomBase:al] synonym: "unclustered kinetochores" RELATED [PomBase:al] is_a: FYPO:0001778 ! abnormal centromere localization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0007067 ! mitotic nuclear division intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0072766 ! centromere clustering at the nuclear envelope intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0007067 ! mitotic nuclear division relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0072766 ! centromere clustering at the nuclear envelope relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-11-21T14:33:41Z [Term] id: FYPO:0001782 name: constricted nucleus def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the nucleus is constricted in the middle, resembling a figure 8." [PomBase:mah] synonym: "constricted nuclei" EXACT [PomBase:vw] synonym: "constricted nucleus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "constricted nucleus during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000062 ! abnormal nuclear morphology during vegetative growth is_a: PATO:0001847 ! constricted intersection_of: PATO:0001847 ! constricted intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005634 ! nucleus relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005634 ! nucleus created_by: midori creation_date: 2012-11-21T14:49:49Z [Term] id: FYPO:0001783 name: elongated, constricted nucleus def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the nucleus is constricted in the middle, resembling a figure 8." [PomBase:mah] synonym: "elongated, constricted nuclei" EXACT [PomBase:vw] synonym: "elongated, constricted nucleus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "elongated, constricted nucleus during vegetative growth" EXACT [PomBase:mah] synonym: "long constricted nucleus" EXACT [PomBase:vw] is_a: FYPO:0001321 ! cellular physical quality phenotype during vegetative growth intersection_of: FYPO:0000136 ! cellular physical quality phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000832 ! elongated nucleus intersection_of: has_part FYPO:0001782 ! constricted nucleus relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000832 ! elongated nucleus relationship: has_part FYPO:0001782 ! constricted nucleus created_by: midori creation_date: 2012-11-21T14:51:08Z [Term] id: FYPO:0001784 name: excess endoplasmic reticulum membrane present def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells contain more endoplasmic reticulum (ER) membrane than normal. Excess ER membranes may form abnormal structures." [PomBase:al, PomBase:mah] synonym: "endoplasmic reticulum membrane present in greater amount" EXACT [PomBase:mah] synonym: "excess endoplasmic reticulum membrane present during mitotic cell cycle" RELATED [PomBase:mah] synonym: "excess endoplasmic reticulum membrane present during vegetative growth" EXACT [PomBase:mah] synonym: "excess ER membrane present" EXACT [PomBase:mah] synonym: "increased endoplasmic reticulum membrane proliferation" RELATED [PomBase:mah] synonym: "overdeveloped ER membrane" EXACT [PomBase:al] is_a: FYPO:0000354 ! abnormal endoplasmic reticulum morphology is_a: FYPO:0002652 ! excess intracellular endomembrane system present is_a: PATO:0002002 ! has extra parts of type intersection_of: PATO:0002002 ! has extra parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0005789 ! endoplasmic reticulum membrane relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0005789 ! endoplasmic reticulum membrane created_by: midori creation_date: 2012-11-21T14:59:30Z [Term] id: FYPO:0001785 name: abnormal sterol binding def: "A molecular function phenotype in which occurrence of sterol binding by a gene product (usually a protein) in a mutant is abnormal. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] comment: This term can be used for any interaction with a sterol that is affected by a mutation, whether or not the mutated gene product is one of the interacting proteins. We recommend noting which proteins were used in the assay when annotating to this term. synonym: "abnormal cholesterol binding" NARROW [PomBase:mah] synonym: "abnormal ergosterol binding" NARROW [PomBase:mah] is_a: FYPO:0000707 ! abnormal molecular function is_a: FYPO:0001092 ! binding phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0032934 ! sterol binding intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0032934 ! sterol binding relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-11-21T15:17:31Z [Term] id: FYPO:0001786 name: abolished sterol binding def: "A molecular function phenotype in which sterol binding by a gene product (usually a protein) in a mutant does not occur. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] comment: This term can be used for any interaction with a sterol that is affected by a mutation, whether or not the mutated gene product is one of the interacting proteins. We recommend noting which proteins were used in the assay when annotating to this term. synonym: "abolished cholesterol binding" NARROW [PomBase:mah] synonym: "abolished ergosterol binding" NARROW [PomBase:mah] synonym: "sterol binding abolished" EXACT [PomBase:mah] is_a: FYPO:0001785 ! abnormal sterol binding is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0032934 ! sterol binding relationship: towards GO:0032934 ! sterol binding created_by: midori creation_date: 2012-11-21T15:17:39Z [Term] id: FYPO:0001787 name: normal sterol binding def: "A molecular function phenotype in which occurrence of sterol binding by a gene product (usually a protein) in a mutant is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cholesterol binding" NARROW [PomBase:mah] synonym: "normal ergosterol binding" NARROW [PomBase:mah] is_a: FYPO:0000706 ! normal molecular function is_a: FYPO:0001092 ! binding phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0032934 ! sterol binding intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0032934 ! sterol binding relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-11-21T15:20:15Z [Term] id: FYPO:0001788 name: normal protein localization to cytoplasm def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to all or part of the cytoplasm is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to cytoplasm" EXACT [PomBase:mah] synonym: "normal protein localization to cytoplasm during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to cytoplasm during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000644 ! normal protein localization during vegetative growth created_by: midori creation_date: 2012-11-21T15:36:24Z [Term] id: FYPO:0001789 name: normal protein localization to nucleus during cellular response to oxidative stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleus is normal (i.e. indistinguishable from wild type) normal protein localization to nucleus during a cellular response to oxidative stress." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to nucleus during cellular response to oxidative stress" EXACT [PomBase:mah] synonym: "normal protein localization to nucleus during cellular response to oxidative stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to nucleus during cellular response to oxidative stress during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein localization to nucleus during oxidative stress" EXACT [PomBase:mah] is_a: FYPO:0000838 ! normal protein localization to nucleus intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0034599 ! cellular response to oxidative stress intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034504 ! protein localization to nucleus intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0034599 ! cellular response to oxidative stress relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034504 ! protein localization to nucleus relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-11-21T15:39:01Z [Term] id: FYPO:0001790 name: normal plasmid loss def: "A cell phenotype in which plasmids are lost at the same frequency as in wild-type cells. Plasmid loss occurs when one or both daughter cells do not inherit copies of a plasmid from the mother cell, and may result from failure of plasmid replication or segregation." [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype is_a: FYPO:0001312 ! normal vegetative phenotype created_by: midori creation_date: 2012-11-21T15:52:33Z [Term] id: FYPO:0001791 name: abnormal spindle pole body duplication def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which spindle pole body duplication is abnormal." [PomBase:mah] synonym: "abnormal SPB duplication" EXACT [PomBase:mah] synonym: "abnormal spindle pole body duplication during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal spindle pole body duplication during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001354 ! abnormal cellular component assembly during vegetative growth is_a: FYPO:0003560 ! abnormal spindle pole body organization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0030474 ! spindle pole body duplication intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0030474 ! spindle pole body duplication relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-11-21T16:01:35Z [Term] id: FYPO:0001792 name: abolished spindle pole body duplication def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which spindle pole body duplication does not occur, leaving the cell with a single spindle pole body later in the cell cycle than normal." [PomBase:mah] synonym: "abolished spindle pole body duplication during mitotic cell cycle" RELATED [PomBase:mah] synonym: "single spindle pole body" RELATED [PomBase:al] synonym: "SPB duplication abolished" EXACT [PomBase:mah] synonym: "spindle pole body duplication abolished" EXACT [PomBase:mah] synonym: "spindle pole body duplication abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001791 ! abnormal spindle pole body duplication is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0030474 ! spindle pole body duplication relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0030474 ! spindle pole body duplication created_by: midori creation_date: 2012-11-21T16:07:06Z [Term] id: FYPO:0001793 name: resistant to cell wall digestion def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell shows increased resistance to conditions that degrade the cell wall." [PomBase:mah] synonym: "resistant to cell wall digestion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistant to cell wall digestion during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001320 ! vegetative cell phenotype created_by: midori creation_date: 2012-11-21T16:14:26Z [Term] id: FYPO:0001794 name: normal RNA level during cellular response to purvalanol A def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to purvalanol A is normal (i.e. indistinguishable from wild type). Total RNA or a specific RNA may be affected." [PomBase:mah] comment: We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "normal mRNA level during cellular response to purvalanol A" NARROW [PomBase:mah] synonym: "normal RNA accumulation during cellular response to purvalanol A" RELATED [PomBase:mah] synonym: "normal RNA level during cellular response to purvalanol A during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal RNA level during cellular response to purvalanol A during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001317 ! normal RNA level during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: exists_during GO:0072754 ! cellular response to purvalanol A intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: exists_during GO:0072754 ! cellular response to purvalanol A relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2012-11-21T16:19:01Z [Term] id: FYPO:0001795 name: normal growth on purvalanol A def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing purvalanol A." [PomBase:mah] synonym: "normal cell population growth in presence of purvalanol A" EXACT [PomBase:mah] synonym: "normal cell population growth on purvalanol A" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to purvalanol A" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on purvalanol A" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2012-11-21T16:22:34Z [Term] id: FYPO:0001796 name: protein mislocalized to centromere def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a protein that is not normally found at the centromeric region of a chromosome is observed there." [PomBase:mah] comment: Note that this term can be used to annotate any case where a protein is found at the centromere in a mutant, but not in wild type. In some cases, there may be enough additional information to annotate to 'abnormal protein localization' (FYPO:0000443) or one of its descendants. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "ectopic protein localization to centromere" EXACT [PomBase:vw] synonym: "protein mislocalised to centromere" EXACT [PomBase:mah] synonym: "protein mislocalised to centromere during vegetative growth" EXACT [PomBase:mah] synonym: "protein mislocalized to centromere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein mislocalized to centromere during vegetative growth" EXACT [PomBase:mah] synonym: "protein mislocalized to chromosome, centromeric region" EXACT [GO:0000775] is_a: FYPO:0000782 ! mislocalized protein during vegetative growth intersection_of: PATO:0000628 ! mislocalised intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CHEBI:36080 ! protein intersection_of: towards GO:0000775 ! chromosome, centromeric region relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CHEBI:36080 ! protein relationship: output_of FYPO:0000449 ! abnormal protein localization to centromere relationship: towards GO:0000775 ! chromosome, centromeric region created_by: midori creation_date: 2012-11-21T16:25:51Z [Term] id: FYPO:0001797 name: abnormal translation def: "A metabolism phenotype observed in the vegetative growth phase of the life cycle in which translation is abnormal. Translation is the synthesis of a protein using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain." [GO:0006412, PomBase:mah] comment: Note that this term should be used only when an experiment measures protein synthesis directly, e.g. by measuring incorporation of a radiolabeled amino acid. Consider annotating to 'altered protein level' (FYPO:0000834) or one of its descendants. synonym: "abnormal protein biosynthesis" EXACT [GO:0006412] synonym: "abnormal protein synthesis" EXACT [GO:0006412] synonym: "abnormal translation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal translation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000291 ! translation phenotype is_a: FYPO:0000328 ! abnormal protein metabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006412 ! translation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006412 ! translation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-11-21T16:31:14Z [Term] id: FYPO:0001798 name: decreased translation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of translation is decreased." [PomBase:mah] comment: Note that this term should be used only when an experiment measures protein synthesis directly, e.g. by measuring incorporation of a radiolabeled amino acid. Consider annotating to 'decreased protein level' (FYPO:0000835) or one of its descendants. synonym: "decreased protein biosynthesis" EXACT [GO:0006412] synonym: "decreased protein synthesis" EXACT [GO:0006412] synonym: "decreased rate of protein synthesis" NARROW [PomBase:al] synonym: "decreased translation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased translation during vegetative growth" EXACT [PomBase:mah] synonym: "reduced translation" EXACT [PomBase:mah] is_a: FYPO:0003124 ! abnormal cytoplasmic translation is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006412 ! translation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_output FYPO:0001324 ! decreased protein level during vegetative growth relationship: inheres_in GO:0006412 ! translation created_by: midori creation_date: 2012-11-21T16:33:39Z [Term] id: FYPO:0001799 name: cell cycle arrest in mitotic G2 phase during response to DNA damage def: "A cellular process phenotype in which progression through the mitotic cell cycle is arrested in G2 phase during a cellular response to DNA damage." [PMID:19366728, PomBase:mah] synonym: "cell cycle arrest in mitotic G2 phase during DNA damage" EXACT [PomBase:mah] synonym: "mitotic cell cycle arrest in G2 phase during response to DNA damage" EXACT [PomBase:mah] synonym: "mitotic G2 phase arrest during response to DNA damage" EXACT [PomBase:mah] is_a: FYPO:0000446 ! cell cycle arrest in mitotic G2 phase intersection_of: during GO:0000085 ! mitotic G2 phase intersection_of: during GO:0006974 ! cellular response to DNA damage stimulus intersection_of: inheres_in GO:0071850 ! mitotic cell cycle arrest intersection_of: qualifier PATO:0000467 ! present relationship: during GO:0000085 ! mitotic G2 phase relationship: during GO:0006974 ! cellular response to DNA damage stimulus relationship: inheres_in GO:0071850 ! mitotic cell cycle arrest relationship: qualifier PATO:0000467 ! present created_by: midori creation_date: 2012-11-21T16:40:19Z [Term] id: FYPO:0001800 name: abolished protein localization to cell tip, with protein distributed in plasma membrane or cortex def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the cell tip is abolished, and the protein is instead detected distributed throughout the plasma membrane and/or cell cortex." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to cell tip, with protein distributed in plasma membrane or cortex" EXACT [PomBase:mah] synonym: "abolished protein localization to cell tip during vegetative growth, with protein distributed in plasma membrane or cortex" EXACT [PomBase:mah] synonym: "abolished protein localization to cell tip, with protein distributed in cell cortex" NARROW [PomBase:mah] synonym: "abolished protein localization to cell tip, with protein distributed in cell membrane or cortex" EXACT [PomBase:mah] synonym: "abolished protein localization to cell tip, with protein distributed in plasma membrane" NARROW [PomBase:mah] synonym: "abolished protein localization to cell tip, with protein distributed in plasma membrane or cortex during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein localization to cell tip abolished, with protein distributed in plasma membrane or cortex" EXACT [PomBase:mah] is_a: FYPO:0001585 ! abolished protein localization to cell tip created_by: midori creation_date: 2012-11-29T10:18:01Z [Term] id: FYPO:0001801 name: inviable cell at high temperature def: "A viability phenotype in which a cell is unable to survive at a high temperature at which wild-type cells survive." [PomBase:mah] comment: For fission yeast, high temperature usually corresponds to above 32 degrees Celsius. Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "essential at high temperature" RELATED [PomBase:mah] synonym: "lethal at high temperature" EXACT [PomBase:mah] is_a: FYPO:0000049 ! inviable cell created_by: midori creation_date: 2012-11-29T10:41:00Z [Term] id: FYPO:0001802 name: elongated cell during cellular response to caffeine def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is elongated during a cellular response to caffeine." [PomBase:mah] synonym: "elongated cell during cellular response to caffeine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "elongated cell during cellular response to caffeine during vegetative growth" EXACT [PomBase:mah] synonym: "elongated in response to caffeine" EXACT [PomBase:al] is_a: FYPO:0001122 ! elongated vegetative cell intersection_of: FYPO:0000017 ! elongated cell intersection_of: exists_during GO:0071313 ! cellular response to caffeine intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: exists_during GO:0071313 ! cellular response to caffeine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) created_by: midori creation_date: 2012-11-29T11:18:42Z [Term] id: FYPO:0001803 name: multiseptate cell during cellular response to caffeine def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell has more than one septum apiece during a cellular response to caffeine." [PomBase:mah] synonym: "multiseptate cell during cellular response to caffeine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "multiseptate cell during cellular response to caffeine during vegetative growth" EXACT [PomBase:mah] synonym: "multiseptate in response to caffeine" EXACT [PomBase:al] is_a: FYPO:0000118 ! multiseptate vegetative cell intersection_of: FYPO:0000118 ! multiseptate vegetative cell intersection_of: exists_during GO:0071313 ! cellular response to caffeine intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: exists_during GO:0071313 ! cellular response to caffeine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) created_by: midori creation_date: 2012-11-29T11:20:49Z [Term] id: FYPO:0001804 name: cell lysis during cellular response to caffeine def: "An inviable phenotype observed in the vegetative growth phase of the life cycle in which a cell lyses, i.e. the plasma membrane ruptures and cytoplasm is lost, during a cellular response to caffeine. Note that in fission yeast cell lysis, the integrity of the cell wall is also compromised." [PomBase:mah] synonym: "cell lysis during cellular response to caffeine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "cell lysis during cellular response to caffeine during vegetative growth" EXACT [PomBase:mah] synonym: "cytolysis during cellular response to caffeine" EXACT [PomBase:mah] synonym: "inviable, lysed cell during cellular response to caffeine" EXACT [PomBase:mah] synonym: "lysed cell in response to caffeine" EXACT [PomBase:al] is_a: FYPO:0000647 ! vegetative cell lysis intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0071313 ! cellular response to caffeine intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0019835 ! cytolysis relationship: happens_during GO:0071313 ! cellular response to caffeine relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0019835 ! cytolysis created_by: midori creation_date: 2012-11-29T11:22:54Z [Term] id: FYPO:0001805 name: normal adenine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which adenine import into the cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal adenine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal adenine import during vegetative growth" EXACT [PomBase:mah] synonym: "normal adenine import into cell" EXACT [PomBase:al] synonym: "normal adenine uptake" EXACT [PomBase:mah] is_a: FYPO:0001071 ! normal transport is_a: FYPO:0001336 ! transport phenotype during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0061488 ! adenine import into cell intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0061488 ! adenine import into cell relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-11-29T11:51:44Z [Term] id: FYPO:0001806 name: normal guanine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which guanine import into the cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal guanine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal guanine import during vegetative growth" EXACT [PomBase:mah] synonym: "normal guanine import into cell" EXACT [PomBase:al] synonym: "normal guanine uptake" EXACT [PomBase:mah] is_a: FYPO:0001071 ! normal transport is_a: FYPO:0001336 ! transport phenotype during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0061489 ! guanine import into cell intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0061489 ! guanine import into cell relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-11-29T11:52:06Z [Term] id: FYPO:0001807 name: abnormal adenine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of adenine into the cell is abnormal." [PomBase:mah] synonym: "abnormal adenine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal adenine import during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal adenine import into cell" EXACT [PomBase:al] synonym: "abnormal adenine uptake" EXACT [PomBase:mah] is_a: FYPO:0001336 ! transport phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0001720 ! abnormal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0061488 ! adenine import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0061488 ! adenine import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-11-29T11:56:11Z [Term] id: FYPO:0001808 name: decreased adenine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of adenine into the cell occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased adenine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased adenine import during vegetative growth" EXACT [PomBase:mah] synonym: "decreased adenine import into cell" EXACT [PomBase:al] synonym: "decreased adenine uptake" EXACT [PomBase:mah] synonym: "reduced adenine import" EXACT [PomBase:mah] is_a: FYPO:0001807 ! abnormal adenine import is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0061488 ! adenine import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0061488 ! adenine import into cell created_by: midori creation_date: 2012-11-29T11:56:22Z [Term] id: FYPO:0001809 name: abnormal guanine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of guanine into the cell is abnormal." [PomBase:mah] synonym: "abnormal guanine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal guanine import during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal guanine import into cell" EXACT [PomBase:al] synonym: "abnormal guanine uptake" EXACT [PomBase:mah] is_a: FYPO:0001336 ! transport phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0001720 ! abnormal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0061489 ! guanine import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0061489 ! guanine import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-11-29T11:57:55Z [Term] id: FYPO:0001810 name: decreased guanine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of guanine into the cell occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased guanine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased guanine import during vegetative growth" EXACT [PomBase:mah] synonym: "decreased guanine import into cell" EXACT [PomBase:al] synonym: "decreased guanine uptake" EXACT [PomBase:mah] synonym: "reduced guanine import" EXACT [PomBase:mah] is_a: FYPO:0001809 ! abnormal guanine import is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0061489 ! guanine import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0061489 ! guanine import into cell created_by: midori creation_date: 2012-11-29T11:58:01Z [Term] id: FYPO:0001811 name: altered 5-phosphoribosyl diphosphate level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of 5-phosphoribosyl diphosphate measured in a cell differs from normal." [PomBase:mah] synonym: "abnormal 5-phosphoribosyl diphosphate level" EXACT [PomBase:mah] synonym: "altered 5-O-phosphono-alpha-D-ribofuranosyl diphosphate level" EXACT [CHEBI:17111] synonym: "altered 5-phosphoribosyl diphosphate level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "altered 5-phosphoribosyl diphosphate level during vegetative growth" EXACT [PomBase:mah] synonym: "altered cellular 5-phosphoribosyl diphosphate level" EXACT [PomBase:mah] is_a: FYPO:0001323 ! altered level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:17111 ! 5-O-phosphono-alpha-D-ribofuranosyl diphosphate relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:17111 ! 5-O-phosphono-alpha-D-ribofuranosyl diphosphate created_by: midori creation_date: 2012-11-29T12:03:30Z [Term] id: FYPO:0001812 name: increased 5-phosphoribosyl diphosphate level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of 5-phosphoribosyl diphosphate measured in a cell is greater than normal." [PomBase:mah] synonym: "increased 5-O-phosphono-alpha-D-ribofuranosyl diphosphate level" EXACT [CHEBI:17111] synonym: "increased 5-phosphoribosyl diphosphate accumulation" RELATED [PomBase:mah] synonym: "increased 5-phosphoribosyl diphosphate level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased 5-phosphoribosyl diphosphate level during vegetative growth" EXACT [PomBase:mah] synonym: "increased cellular 5-phosphoribosyl diphosphate level" EXACT [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth is_a: FYPO:0001811 ! altered 5-phosphoribosyl diphosphate level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:17111 ! 5-O-phosphono-alpha-D-ribofuranosyl diphosphate relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:17111 ! 5-O-phosphono-alpha-D-ribofuranosyl diphosphate created_by: midori creation_date: 2012-11-29T12:03:40Z [Term] id: FYPO:0001813 name: sensitive to N-methyl-N'-nitro-N-nitrosoguanidine def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to N-methyl-N'-nitro-N-nitrosoguanidine. Cells stop growing (and may die) at a concentration of N-methyl-N'-nitro-N-nitrosoguanidine that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to N-methyl-N'-nitro-N-nitrosoguanidine" EXACT [PomBase:mah] synonym: "sensitive to MNNG" EXACT [CHEBI:21759] synonym: "sensitive to N-methyl-N'-nitro-N-nitrosoguanidine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to N-methyl-N'-nitro-N-nitrosoguanidine during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to nitrosoguanidine" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:21759 ! N-methyl-N'-nitro-N-nitrosoguanidine relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:21759 ! N-methyl-N'-nitro-N-nitrosoguanidine created_by: midori creation_date: 2012-11-29T12:47:51Z [Term] id: FYPO:0001814 name: normal cell population growth during iron starvation def: "A cell growth phenotype in which cell population growth is normal (i.e. indistinguishable from wild type) under iron starvation conditions." [PomBase:mah] synonym: "normal cell population growth during iron depletion" EXACT [PomBase:vw] synonym: "normal cell population growth during iron deprivation" EXACT [PomBase:vw] synonym: "normal growth during iron starvation" BROAD [PomBase:mah] is_a: FYPO:0000047 ! normal cell population growth intersection_of: FYPO:0000047 ! normal cell population growth intersection_of: during GO:0010106 ! cellular response to iron ion starvation relationship: during GO:0010106 ! cellular response to iron ion starvation created_by: midori creation_date: 2012-11-29T13:50:46Z [Term] id: FYPO:0001815 name: increased level of Okazaki fragments def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which Okazaki fragments, the DNA segments produced by discontinuous synthesis of the lagging strand during DNA replication, are present at greater levels than normal." [PomBase:mah] synonym: "accumulation of Okazaki fragments" EXACT [PomBase:mah] synonym: "accumulation of Okazaki fragments during vegetative growth" EXACT [PomBase:mah] synonym: "increased level of Okazaki fragments during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased level of Okazaki fragments during vegetative growth" EXACT [PomBase:mah] synonym: "Okazaki fragment accumulation" EXACT [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards SO:0001985 ! Okazaki_fragment relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards SO:0001985 ! Okazaki_fragment created_by: midori creation_date: 2012-11-29T14:28:40Z [Term] id: FYPO:0001816 name: abnormal phosphoribosylamine-glycine ligase activity def: "A molecular function phenotype in which the observed rate of phosphoribosylamine-glycine ligase activity is abnormal." [PomBase:mah] synonym: "abnormal GAR synthetase activity" EXACT [GO:0004637] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004637 ! phosphoribosylamine-glycine ligase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004637 ! phosphoribosylamine-glycine ligase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-11-29T14:32:55Z [Term] id: FYPO:0001817 name: abolished phosphoribosylamine-glycine ligase activity def: "A molecular function phenotype in which phosphoribosylamine-glycine ligase activity is absent." [PomBase:mah] synonym: "abolished GAR synthetase activity" EXACT [GO:0004637] synonym: "phosphoribosylamine-glycine ligase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0001816 ! abnormal phosphoribosylamine-glycine ligase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0004637 ! phosphoribosylamine-glycine ligase activity relationship: towards GO:0004637 ! phosphoribosylamine-glycine ligase activity created_by: midori creation_date: 2012-11-29T14:33:03Z [Term] id: FYPO:0001818 name: abnormal phosphoribosylformylglycinamidine cyclo-ligase activity def: "A molecular function phenotype in which the observed rate of phosphoribosylformylglycinamidine cyclo-ligase activity is abnormal." [PomBase:mah] synonym: "abnormal AIR synthase activity" EXACT [GO:0004641] synonym: "abnormal AIR synthetase activity" EXACT [GO:0004641] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004641 ! phosphoribosylformylglycinamidine cyclo-ligase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004641 ! phosphoribosylformylglycinamidine cyclo-ligase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-11-08T13:54:28Z [Term] id: FYPO:0001819 name: abolished phosphoribosylformylglycinamidine cyclo-ligase activity def: "A molecular function phenotype in which phosphoribosylformylglycinamidine cyclo-ligase activity is absent." [PomBase:mah] synonym: "abolished AIR synthase activity" EXACT [GO:0004641] synonym: "abolished AIR synthetase activity" EXACT [GO:0004641] synonym: "phosphoribosylformylglycinamidine cyclo-ligase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0001818 ! abnormal phosphoribosylformylglycinamidine cyclo-ligase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0004641 ! phosphoribosylformylglycinamidine cyclo-ligase activity relationship: towards GO:0004641 ! phosphoribosylformylglycinamidine cyclo-ligase activity created_by: midori creation_date: 2013-11-08T13:54:35Z [Term] id: FYPO:0001820 name: normal growth on lithium ion def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing lithium ions." [PomBase:mah] synonym: "normal cell population growth in presence of lithium ions" EXACT [PomBase:mah] synonym: "normal cell population growth on lithium" EXACT [PomBase:mah] synonym: "normal cell population growth on lithium ion" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to lithium ion" RELATED [PomBase:mah] synonym: "normal vegetative cell population growth on lithium ion" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:49713 ! lithium(1+) relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:49713 ! lithium(1+) created_by: midori creation_date: 2012-11-29T14:51:06Z [Term] id: FYPO:0001821 name: increased number of heterothallic h+ cells def: "A cell population phenotype in which greater than normal number of cells in an originally homothallic (h90) population express P-specific information from the mat1 locus." [PomBase:al] synonym: "increased amount of heterothallic H+ cells" EXACT [PomBase:al] is_a: FYPO:0000003 ! cell population phenotype is_a: FYPO:0001985 ! abnormal phenotype created_by: midori creation_date: 2012-11-29T14:56:17Z [Term] id: FYPO:0001822 name: mating cassette duplication def: "A cell phenotype in which one or more of the mating cassettes is duplicated." [PomBase:mah] is_a: FYPO:0000641 ! abnormal chromosome organization created_by: midori creation_date: 2012-11-29T15:05:18Z [Term] id: FYPO:0001823 name: sensitive to chlorpromazine def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to chlorpromazine. Cells stop growing (and may die) at a concentration of chlorpromazine that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to chlorpromazine" EXACT [PomBase:mah] synonym: "sensitive to chlorpromazine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to chlorpromazine during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:3647 ! chlorpromazine relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:3647 ! chlorpromazine created_by: midori creation_date: 2012-11-29T15:16:28Z [Term] id: FYPO:0001824 name: sensitive to trifluoperazine def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to trifluoperazine. Cells stop growing (and may die) at a concentration of trifluoperazine that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to trifluoperazine" EXACT [PomBase:mah] synonym: "sensitive to trifluoperazine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to trifluoperazine during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:45951 ! trifluoperazine relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:45951 ! trifluoperazine created_by: midori creation_date: 2012-11-29T15:16:45Z [Term] id: FYPO:0001825 name: increased sodium export def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the export of sodium ions out of a cell or organelle occurs to a greater extent than normal." [PomBase:mah] synonym: "increased cellular sodium export" EXACT [PomBase:al] synonym: "increased sodium export during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased sodium export during vegetative growth" EXACT [PomBase:mah] synonym: "increased sodium export from cell" NARROW [PomBase:mah] synonym: "increased sodium ion export" EXACT [PomBase:mah] is_a: FYPO:0001721 ! abnormal sodium export is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071436 ! sodium ion export relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071436 ! sodium ion export created_by: midori creation_date: 2012-11-29T15:25:30Z [Term] id: FYPO:0001826 name: abolished sodium export def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the export of sodium ions out of a cell or organelle does not occur." [PomBase:mah] synonym: "abolished sodium export during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sodium export abolished" EXACT [PomBase:mah] synonym: "sodium export abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001721 ! abnormal sodium export is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0071436 ! sodium ion export relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0071436 ! sodium ion export created_by: midori creation_date: 2012-11-29T15:26:28Z [Term] id: FYPO:0001827 name: abnormal glucose import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of glucose into the cell is abnormal." [PomBase:mah] synonym: "abnormal glucose import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal glucose import during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal glucose import into cell" EXACT [PomBase:al] synonym: "abnormal glucose uptake" EXACT [PomBase:mah] is_a: FYPO:0001336 ! transport phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0001720 ! abnormal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0061490 ! glucose import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0061490 ! glucose import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-11-29T15:31:47Z [Term] id: FYPO:0001828 name: glucose import abolished def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of guanine into the cell does not occur." [PomBase:mah] synonym: "abolished glucose import into cell" EXACT [PomBase:al] synonym: "abolished glucose uptake" EXACT [PomBase:mah] synonym: "glucose import abolished during mitotic cell cycle" RELATED [PomBase:mah] synonym: "glucose import abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001827 ! abnormal glucose import is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0061490 ! glucose import into cell relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0061490 ! glucose import into cell created_by: midori creation_date: 2012-11-29T15:31:54Z [Term] id: FYPO:0001829 name: normal growth on gluconate carbon source def: "A vegetative cell population growth phenotype in which cells grow normally in a medium containing gluconate as the carbon source." [PomBase:mah] synonym: "normal cell population growth on gluconate carbon source" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal vegetative cell population growth on gluconate carbon source" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0000047 ! normal cell population growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:24265 ! gluconate relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:24265 ! gluconate created_by: midori creation_date: 2012-11-29T15:40:50Z [Term] id: FYPO:0001830 name: decreased cell population growth on gluconate carbon source def: "A vegetative cell population growth phenotype in which cell growth is decreased relative to normal in a medium containing gluconate as the carbon source." [PomBase:mah] comment: Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "decreased growth on gluconate carbon source" BROAD [PomBase:mah] synonym: "decreased vegetative cell growth on gluconate carbon source" EXACT [PomBase:mah] synonym: "reduced cell growth on gluconate carbon source" EXACT [PomBase:mah] synonym: "slow cell growth on gluconate carbon source" NARROW [PomBase:mah] is_a: FYPO:0001355 ! decreased vegetative cell population growth intersection_of: FYPO:0000046 ! decreased cell population growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:24265 ! gluconate relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:24265 ! gluconate created_by: midori creation_date: 2012-11-29T15:45:12Z [Term] id: FYPO:0001831 name: abnormal phosphoglycerate mutase activity def: "A molecular function phenotype in which the observed rate of phosphoglycerate mutase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004619 ! phosphoglycerate mutase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004619 ! phosphoglycerate mutase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-11-29T15:47:47Z [Term] id: FYPO:0001832 name: abolished phosphoglycerate mutase activity def: "A molecular function phenotype in which phosphoglycerate mutase activity is absent." [PomBase:mah] synonym: "phosphoglycerate mutase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0001831 ! abnormal phosphoglycerate mutase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0004619 ! phosphoglycerate mutase activity relationship: towards GO:0004619 ! phosphoglycerate mutase activity created_by: midori creation_date: 2012-11-29T15:48:02Z [Term] id: FYPO:0001833 name: increased phosphoglycerate mutase activity def: "A molecular function phenotype in which the observed rate of phosphoglycerate mutase activity is increased." [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0001831 ! abnormal phosphoglycerate mutase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0004619 ! phosphoglycerate mutase activity relationship: inheres_in GO:0004619 ! phosphoglycerate mutase activity created_by: midori creation_date: 2012-11-29T15:48:26Z [Term] id: FYPO:0001834 name: normal phosphoglycerate mutase activity def: "A molecular function phenotype in which the observed rate of phosphoglycerate mutase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004619 ! phosphoglycerate mutase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0004619 ! phosphoglycerate mutase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-11-29T15:50:29Z [Term] id: FYPO:0001835 name: normal growth on acidic medium def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium that is more acidic than standard fission yeast media (about 5.8)." [PomBase:mah] synonym: "normal cell population growth on acidic medium" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to acidity" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on acidic medium" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth created_by: midori creation_date: 2012-12-12T18:04:19Z [Term] id: FYPO:0001836 name: normal protein localization to spindle pole body def: "A cell phenotype in which the localization of a protein to the spindle pole body is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to spindle pole body" EXACT [PomBase:mah] synonym: "normal protein localization to SPB" EXACT [PomBase:mah] is_a: FYPO:0004096 ! normal protein localization to cytoskeleton intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0071988 ! protein localization to spindle pole body intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0071988 ! protein localization to spindle pole body relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-12-06T15:30:01Z [Term] id: FYPO:0001837 name: increased duration of protein localization to mitotic spindle pole body def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which one or more proteins is localized to the mitotic spindle pole body for a longer time than normal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased duration of protein localisation to mitotic spindle pole body" EXACT [PomBase:mah] synonym: "increased duration of protein localization to mitotic SPB" EXACT [PomBase:mah] synonym: "increased duration of protein localization to spindle pole body during vegetative growth" EXACT [PomBase:mah] synonym: "prolonged protein localization to mitotic spindle pole body" EXACT [PomBase:vw] is_a: FYPO:0000939 ! abnormal protein localization to mitotic spindle pole body is_a: FYPO:0004023 ! increased duration of protein localization to mitotic spindle intersection_of: PATO:0000498 ! increased duration intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902440 ! protein localization to mitotic spindle pole body relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902440 ! protein localization to mitotic spindle pole body created_by: midori creation_date: 2012-12-06T15:31:27Z [Term] id: FYPO:0001838 name: decreased protein phosphorylation during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein phosphorylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "reduced protein phosphorylation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000545 ! decreased protein modification during vegetative growth is_a: FYPO:0000775 ! abnormal protein phosphorylation during vegetative growth is_a: FYPO:0002679 ! decreased protein phosphorylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2012-12-06T15:37:32Z [Term] id: FYPO:0001839 name: normal minichromosome loss def: "A cell phenotype in which minichromosomes are lost at the same frequency as in wild-type cells. Minichromosome loss occurs when one or both daughter cells do not inherit copies of a minichromosome from the mother cell, and may result from failure of minichromosome replication or segregation." [PomBase:mah] comment: In fission yeast, a minichromosome is a large portion of a chromosome, usually about half of chromosome 3, that replicates and segregates autonomously. For smaller autonomously replicating and segregating constructs, consider 'normal plasmid loss' (FYPO:0001790). is_a: FYPO:0001312 ! normal vegetative phenotype created_by: midori creation_date: 2012-12-06T16:04:43Z [Term] id: FYPO:0001840 name: increased minichromosome loss during vegetative growth def: "A cell phenotype in which minichromosomes are lost at a higher frequency than normal during the vegetative growth phase of the life cycle. Minichromosome loss occurs when one or both daughter cells do not inherit copies of a minichromosome from the mother cell, and may result from failure of minichromosome replication or segregation." [PomBase:mah] comment: Note that in budding yeast, increased plasmid loss is often called a minichromosome maintenance defect, because "minichromosome" is roughly synonymous with an autonomously replicated and segregated plasmid in that organism. In fission yeast, a minichromosome is a large portion of a chromosome, usually about half of chromosome 3, that replicates and segregates autonomously. For smaller autonomously replicating and segregating constructs, consider 'increased plasmid loss' (FYPO:0000786). synonym: "increased plasmid loss during mitotic cell cycle" EXACT [PomBase:mah] synonym: "mitotic minichromosome maintenance defect" RELATED [PomBase:mah] is_a: FYPO:0001320 ! vegetative cell phenotype is_a: FYPO:0001859 ! increased minichromosome loss created_by: midori creation_date: 2012-12-06T16:08:24Z [Term] id: FYPO:0001841 name: abnormal adenylyl cyclase activity def: "A molecular function phenotype in which the observed rate of adenylyl cyclase activity is abnormal." [PomBase:mah] synonym: "abnormal adenylate cyclase activity" EXACT [GO:0004016] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004016 ! adenylate cyclase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004016 ! adenylate cyclase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-12-06T16:11:23Z [Term] id: FYPO:0001842 name: increased adenylyl cyclase activity def: "A molecular function phenotype in which the observed rate of adenylyl cyclase activity is increased." [PomBase:mah] synonym: "increased adenylate cyclase activity" EXACT [GO:0004016] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0001841 ! abnormal adenylyl cyclase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0004016 ! adenylate cyclase activity relationship: inheres_in GO:0004016 ! adenylate cyclase activity created_by: midori creation_date: 2012-12-06T16:11:34Z [Term] id: FYPO:0001843 name: sensitive to rhizoxin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to rhizoxin. Cells stop growing (and may die) at a concentration of rhizoxin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to rhizoxin" EXACT [PomBase:mah] synonym: "sensitive to rhizoxin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to rhizoxin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:72590 ! rhizoxin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:72590 ! rhizoxin created_by: midori creation_date: 2012-12-13T12:08:25Z [Term] id: FYPO:0001844 name: sensitive to ansamitocin P-3 def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to ansamitocin P-3. Cells stop growing (and may die) at a concentration of ansamitocin P-3 that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to ansamitocin P-3" EXACT [PomBase:mah] synonym: "sensitive to ansamitocin P-3 during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to ansamitocin P-3 during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:29515 ! ansamitocin P3 relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:29515 ! ansamitocin P3 created_by: midori creation_date: 2012-12-13T12:20:43Z [Term] id: FYPO:0001845 name: normal kinetochore organization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which kinetochore organization is normal (i.e. indistinguishable from wild type). Kinetochore organization is the assembly, arrangement of constituent parts, or disassembly of kinetochores and their associated proteins." [GO:0051383, PomBase:mah] synonym: "normal kinetochore organisation" EXACT [PomBase:mah] synonym: "normal kinetochore organization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal kinetochore organization during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001319 ! normal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051383 ! kinetochore organization intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051383 ! kinetochore organization relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-12-18T12:05:03Z [Term] id: FYPO:0001846 name: increased duration of mitotic anaphase A def: "A cellular process phenotype in which the duration of progression through anaphase A of mitosis is longer than normal. Anaphase A is the mitotic cell cycle phase during which the kinetochore microtubules shorten as chromosomes move toward the spindle poles." [GO:0000091, PomBase:mah] synonym: "delayed mitotic anaphase A progression" RELATED [PomBase:mah] synonym: "increased duration of mitotic anaphase A during vegetative growth" EXACT [PomBase:mah] synonym: "increased duration of mitotic anaphase A progression" EXACT [PomBase:mah] synonym: "prolonged mitotic anaphase A" EXACT [PomBase:mah] is_a: FYPO:0000618 ! increased duration of mitotic anaphase intersection_of: PATO:0000498 ! increased duration intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000091 ! mitotic anaphase A relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000091 ! mitotic anaphase A created_by: midori creation_date: 2012-12-18T12:10:55Z [Term] id: FYPO:0001847 name: abnormal ferric-chelate reductase activity def: "A molecular function phenotype in which the observed rate of ferric-chelate reductase activity is abnormal." [PomBase:mah] is_a: FYPO:0000689 ! abnormal oxidoreductase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0000293 ! ferric-chelate reductase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0000293 ! ferric-chelate reductase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-12-18T13:35:13Z [Term] id: FYPO:0001848 name: abolished ferric-chelate reductase activity def: "A molecular function phenotype in which ferric-chelate reductase activity is absent." [PomBase:mah] synonym: "ferric-chelate reductase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0001847 ! abnormal ferric-chelate reductase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0000293 ! ferric-chelate reductase activity relationship: towards GO:0000293 ! ferric-chelate reductase activity created_by: midori creation_date: 2012-12-18T13:35:24Z [Term] id: FYPO:0001849 name: abnormal ferric iron import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of ferric iron ions into a cell is abnormal." [PomBase:mah] synonym: "abnormal cellular ferric iron import" EXACT [PomBase:al] synonym: "abnormal ferric ion import" EXACT [PomBase:mah] synonym: "abnormal ferric iron import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal ferric iron import during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal ferric iron import into cell" EXACT [PomBase:mah] is_a: FYPO:0001336 ! transport phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0001720 ! abnormal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0097461 ! ferric iron import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0097461 ! ferric iron import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-12-18T13:37:37Z [Term] id: FYPO:0001850 name: decreased ferric iron import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of ferric iron ions into a cell occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased cellular ferric iron import" EXACT [PomBase:al] synonym: "decreased ferric ion import" EXACT [PomBase:mah] synonym: "decreased ferric iron import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased ferric iron import during vegetative growth" EXACT [PomBase:mah] synonym: "decreased ferric iron import into cell" NARROW [PomBase:mah] synonym: "reduced ferric iron import" EXACT [PomBase:mah] is_a: FYPO:0001849 ! abnormal ferric iron import is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0097461 ! ferric iron import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0097461 ! ferric iron import into cell created_by: midori creation_date: 2012-12-18T13:37:47Z [Term] id: FYPO:0001851 name: normal ferrous iron import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which ferrous iron import is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal ferrous ion import" EXACT [PomBase:mah] synonym: "normal ferrous iron import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal ferrous iron import during vegetative growth" EXACT [PomBase:mah] synonym: "normal ferrous iron import into cell" EXACT [PomBase:al] is_a: FYPO:0001071 ! normal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0097460 ! ferrous iron import into cell intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0097460 ! ferrous iron import into cell relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-12-18T13:57:53Z [Term] id: FYPO:0001852 name: decreased transcription during iron starvation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription occurs to a lower extent than normal when the cell is subject to iron ion starvation. All genes, or a specific subset of genes, may be affected." [PomBase:mah] comment: Use this term if there is evidence, such as labeled nucleotide incorporation, showing that transcription rather than RNA stability is affected; otherwise, use 'decreased RNA level' (FYPO:0000826). synonym: "decreased transcription during iron depletion" EXACT [PomBase:vw] synonym: "decreased transcription during iron deprivation" EXACT [PomBase:vw] synonym: "decreased transcription during iron ion starvation" EXACT [PomBase:mah] synonym: "decreased transcription during iron starvation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased transcription during iron starvation during vegetative growth" EXACT [PomBase:mah] synonym: "reduced transcription during iron starvation" EXACT [PomBase:mah] is_a: FYPO:0000781 ! decreased transcription during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0010106 ! cellular response to iron ion starvation intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006351 ! transcription, DNA-templated relationship: happens_during GO:0010106 ! cellular response to iron ion starvation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_output FYPO:0002042 ! decreased RNA level during cellular response to iron ion starvation relationship: inheres_in GO:0006351 ! transcription, DNA-templated created_by: midori creation_date: 2012-12-18T14:13:16Z [Term] id: FYPO:0001853 name: abolished transcription during iron starvation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription does not occur when the cell is subject to iron ion starvation. All genes, or a specific subset of genes, may be affected." [PomBase:mah] synonym: "abolished transcription during iron depletion" EXACT [PomBase:vw] synonym: "abolished transcription during iron deprivation" EXACT [PomBase:vw] synonym: "abolished transcription during iron ion starvation" EXACT [PomBase:mah] synonym: "abolished transcription during iron starvation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished transcription during iron starvation during vegetative growth" EXACT [PomBase:mah] synonym: "transcription abolished during iron starvation" EXACT [PomBase:mah] is_a: FYPO:0001443 ! abolished transcription during vegetative growth is_a: FYPO:0001852 ! decreased transcription during iron starvation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: happens_during GO:0010106 ! cellular response to iron ion starvation intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0006351 ! transcription, DNA-templated relationship: happens_during GO:0010106 ! cellular response to iron ion starvation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0006351 ! transcription, DNA-templated created_by: midori creation_date: 2012-12-18T14:13:28Z [Term] id: FYPO:0001854 name: increased transcription during cellular response to iron def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription occurs to a greater extent than normal during a cellular response to iron ions. All genes, or a specific subset of genes, may be affected." [PomBase:mah] synonym: "increased transcription during cellular response to iron during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased transcription during cellular response to iron during vegetative growth" EXACT [PomBase:mah] synonym: "increased transcription during cellular response to iron ion" EXACT [PomBase:mah] is_a: FYPO:0000780 ! increased transcription during vegetative growth intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0071281 ! cellular response to iron ion intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006351 ! transcription, DNA-templated relationship: happens_during GO:0071281 ! cellular response to iron ion relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006351 ! transcription, DNA-templated created_by: midori creation_date: 2012-12-18T14:20:09Z [Term] id: FYPO:0001855 name: normal transcription during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription occurs to a normal (i.e. indistinguishable from wild type) extent. All genes, or a specific subset of genes, may be measured." [PomBase:mah] synonym: "normal transcription during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal transcription during vegetative growth" EXACT [PomBase:mah] synonym: "normal transcription, DNA-dependent, during vegetative growth" EXACT [GO:0006351, PomBase:mah] is_a: FYPO:0000859 ! normal metabolic process during vegetative growth is_a: FYPO:0002882 ! normal transcription intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006351 ! transcription, DNA-templated intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006351 ! transcription, DNA-templated relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-12-18T14:22:58Z [Term] id: FYPO:0001856 name: normal transcription during iron starvation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription occurs to a normal (i.e. indistinguishable from wild type) extent when the cell is subject to iron ion starvation. All genes, or a specific subset of genes, may be measured." [PomBase:mah] synonym: "normal transcription during iron depletion" EXACT [PomBase:vw] synonym: "normal transcription during iron deprivation" EXACT [PomBase:vw] synonym: "normal transcription during iron ion starvation" EXACT [PomBase:mah] synonym: "normal transcription during iron starvation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal transcription during iron starvation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000968 ! normal cellular response to stress is_a: FYPO:0001855 ! normal transcription during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0010106 ! cellular response to iron ion starvation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0010106 ! cellular response to iron ion starvation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-12-18T14:25:24Z [Term] id: FYPO:0001857 name: normal transcription during cellular response to iron def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription occurs to a normal (i.e. indistinguishable from wild type) extent during a cellular response to iron ions. All genes, or a specific subset of genes, may be measured." [PomBase:mah] synonym: "normal transcription during cellular response to iron during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal transcription during cellular response to iron during vegetative growth" EXACT [PomBase:mah] synonym: "normal transcription during cellular response to iron ion" EXACT [PomBase:mah] is_a: FYPO:0001318 ! normal cellular response to chemical stimulus during vegetative growth is_a: FYPO:0001855 ! normal transcription during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071281 ! cellular response to iron ion intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071281 ! cellular response to iron ion relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2012-12-18T14:26:34Z [Term] id: FYPO:0001858 name: increased fatty acid synthase activity def: "A molecular function phenotype in which the observed rate of fatty acid synthase activity is increased." [PomBase:mah] synonym: "increased FAS activity" EXACT [PomBase:al, PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0000720 ! abnormal fatty acid synthase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0004312 ! fatty acid synthase activity relationship: inheres_in GO:0004312 ! fatty acid synthase activity created_by: midori creation_date: 2012-12-18T14:33:31Z [Term] id: FYPO:0001859 name: increased minichromosome loss def: "A cell phenotype in which minichromosomes are lost at a higher frequency than normal. Minichromosome loss occurs when one or both daughter cells do not inherit copies of a minichromosome from the mother cell, and may result from failure of minichromosome replication or segregation." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. Note that in budding yeast, increased plasmid loss is often called a minichromosome maintenance defect, because "minichromosome" is roughly synonymous with an autonomously replicated and segregated plasmid in that organism. In fission yeast, a minichromosome is a large portion of a chromosome, usually about half of chromosome 3, that replicates and segregates autonomously. For smaller autonomously replicating and segregating constructs, consider 'increased plasmid loss' (FYPO:0000786). subset: qc_do_not_manually_annotate synonym: "minichromosome maintenance defect" RELATED [PomBase:mah] is_a: FYPO:0003037 ! abnormal cell phenotype created_by: midori creation_date: 2012-12-18T14:36:26Z [Term] id: FYPO:0001860 name: increased minichromosome loss during meiotic cell cycle def: "A cell phenotype in which minichromosomes are lost at a higher frequency than normal during the meiotic cell cycle. Minichromosome loss occurs when one or both daughter cells do not inherit copies of a minichromosome from the mother cell, and may result from failure of minichromosome replication or segregation." [PomBase:mah] synonym: "increased minichromosome loss during meiosis" RELATED [PomBase:mah] synonym: "meiotic minichromosome maintenance defect" RELATED [PomBase:mah] is_a: FYPO:0001859 ! increased minichromosome loss created_by: midori creation_date: 2012-12-18T14:43:49Z [Term] id: FYPO:0001861 name: increased minichromosome loss upon segregation during vegetative growth def: "A cell phenotype in which minichromosomes are lost due to abnormal mitotic sister chromatid segregation at a higher frequency than normal." [PomBase:mah] comment: Use this term if the assay to detect minichromosome loss can distinguish a segregation defect from a replication defect (e.g. by microscopy). Note that in budding yeast, increased plasmid loss is often called a minichromosome maintenance defect, because "minichromosome" is roughly synonymous with an autonomously replicated and segregated plasmid in that organism. In fission yeast, a minichromosome is a large portion of a chromosome, usually about half of chromosome 3, that replicates and segregates autonomously. For smaller autonomously replicating and segregating constructs, consider 'increased plasmid loss' (FYPO:0000786). synonym: "increased plasmid loss upon segregation during mitotic cell cycle" EXACT [PomBase:mah] synonym: "mitotic minichromosome maintenance defect" RELATED [PomBase:mah] is_a: FYPO:0001840 ! increased minichromosome loss during vegetative growth relationship: output_of FYPO:0000141 ! abnormal mitotic sister chromatid segregation created_by: midori creation_date: 2012-12-18T14:45:41Z [Term] id: FYPO:0001862 name: increased minichromosome loss upon segregation during meiotic cell cycle def: "A cell phenotype in which minichromosomes are lost due to abnormal meiotic chromosome segregation at a higher frequency than normal." [PomBase:mah] comment: Use this term if the assay to detect minichromosome loss can distinguish a segregation defect from a replication defect (e.g. by microscopy). Note that in budding yeast, increased plasmid loss is often called a minichromosome maintenance defect, because "minichromosome" is roughly synonymous with an autonomously replicated and segregated plasmid in that organism. In fission yeast, a minichromosome is a large portion of a chromosome, usually about half of chromosome 3, that replicates and segregates autonomously. For smaller autonomously replicating and segregating constructs, consider 'increased plasmid loss' (FYPO:0000786). synonym: "increased plasmid loss upon segregation during meiosis" RELATED [PomBase:mah] synonym: "meiotic minichromosome maintenance defect" RELATED [PomBase:mah] is_a: FYPO:0001860 ! increased minichromosome loss during meiotic cell cycle relationship: output_of FYPO:0000151 ! abnormal meiotic chromosome segregation created_by: midori creation_date: 2012-12-18T14:55:41Z [Term] id: FYPO:0001863 name: abolished leptomycin B binding def: "A molecular function phenotype in which leptomycin B binding by a gene product does not occur. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "abolished LMB binding" EXACT [PomBase:al] synonym: "leptomycin B binding abolished" EXACT [PomBase:mah] is_a: FYPO:0001092 ! binding phenotype is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: happens_during GO:0010106 ! cellular response to iron ion starvation intersection_of: towards GO:1901707 ! leptomycin B binding relationship: happens_during GO:0010106 ! cellular response to iron ion starvation relationship: towards GO:1901707 ! leptomycin B binding created_by: midori creation_date: 2012-12-18T15:04:38Z [Term] id: FYPO:0001864 name: conjugation without glucose starvation def: "A cellular process phenotype in which conjugation takes place in cells that are not subject to glucose starvation." [PomBase:mah] synonym: "conjugation in the absence of glucose starvation" EXACT [PomBase:al] synonym: "conjugation without glucose depletion" EXACT [PomBase:vw] synonym: "conjugation without glucose deprivation" EXACT [PomBase:vw] is_a: FYPO:0000031 ! abnormal conjugation created_by: midori creation_date: 2012-12-18T15:35:33Z [Term] id: FYPO:0001865 name: normal negative regulation of transcription by glucose def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which negative regulation of transcription by glucose (glucose repression) is normal. Transcription of specific genes is repressed in the presence of glucose, as in wild type." [GO:0045014, PomBase:mah] synonym: "normal glucose repression" EXACT [GO:0045014, PomBase:mah] synonym: "normal glucose repression during vegetative growth" EXACT [PomBase:mah] synonym: "normal negative regulation of transcription by glucose during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal negative regulation of transcription by glucose during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001319 ! normal cellular process during vegetative growth is_a: FYPO:0001342 ! cellular response phenotype during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0045014 ! negative regulation of transcription by glucose intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0045014 ! negative regulation of transcription by glucose relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-01-09T15:24:17Z [Term] id: FYPO:0001866 name: normal adenylyl cyclase activity def: "A molecular function phenotype in which the observed rate of adenylyl cyclase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal adenylate cyclase activity" EXACT [GO:0004016] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004016 ! adenylate cyclase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0004016 ! adenylate cyclase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-01-09T15:30:04Z [Term] id: FYPO:0001867 name: increased shmoo formation def: "A cellular process phenotype in which the occurrence of mating projection assembly is increased." [PomBase:mah] synonym: "increased conjugation tube formation" EXACT [PMID:1905818, PomBase:mah] synonym: "increased mating projection assembly" EXACT [PomBase:mah] synonym: "increased mating projection formation" EXACT [PomBase:mah] synonym: "increased shmoo assembly" EXACT [PomBase:mah] is_a: FYPO:0000568 ! abnormal shmoo formation is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0031382 ! mating projection assembly relationship: inheres_in GO:0031382 ! mating projection assembly created_by: midori creation_date: 2013-01-28T13:42:55Z [Term] id: FYPO:0001868 name: decreased adenylyl cyclase activity def: "A molecular function phenotype in which the observed rate of adenylyl cyclase activity is decreased." [PomBase:mah] synonym: "decreased adenylate cyclase activity" EXACT [GO:0004016] synonym: "reduced adenylyl cyclase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0001841 ! abnormal adenylyl cyclase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004016 ! adenylate cyclase activity relationship: inheres_in GO:0004016 ! adenylate cyclase activity created_by: midori creation_date: 2013-01-09T15:32:06Z [Term] id: FYPO:0001869 name: abolished adenylyl cyclase activity def: "A molecular function phenotype in which adenylyl cyclase activity is absent." [PomBase:mah] synonym: "abolished adenylate cyclase activity" EXACT [GO:0004016] synonym: "adenylyl cyclase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0001841 ! abnormal adenylyl cyclase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0004016 ! adenylate cyclase activity relationship: towards GO:0004016 ! adenylate cyclase activity created_by: midori creation_date: 2013-01-09T15:32:19Z [Term] id: FYPO:0001870 name: normal centromere clustering at nuclear periphery def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of centromeres and associated kinetochores into a cluster at the nuclear periphery is normal (i.e. indistinguishable from wild type). Centromere-kinetochore complexes normally cluster near the old spindle pole body during interphase of the mitotic cell cycle." [PomBase:mah] synonym: "normal centromere clustering at nuclear periphery during interphase of mitotic cell cycle" EXACT [PomBase:mah] synonym: "normal centromere clustering at nuclear periphery during mitotic cell cycle" EXACT [PomBase:mah] synonym: "normal centromere clustering at nuclear periphery during vegetative growth" EXACT [PomBase:mah] synonym: "normal centromere clustering at SPB" RELATED [PomBase:mah] synonym: "normal centromere clustering at spindle pole body" RELATED [GO:0072766, PomBase:mah] synonym: "normal centromere-SPB clustering" RELATED [GO:0072766] synonym: "normal kinetochore clustering at SPB" RELATED [GO:0072766] synonym: "normal kinetochore clustering at spindle pole body" RELATED [PomBase:mah] synonym: "normal kinetochore localization at spindle pole body" RELATED [GO:0072766] is_a: FYPO:0000644 ! normal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072766 ! centromere clustering at the nuclear envelope intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072766 ! centromere clustering at the nuclear envelope relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-01-09T15:36:22Z [Term] id: FYPO:0001871 name: increased agglutination def: "A cell adhesion phenotype in which cells adhere to other cells of compatible mating type more strongly or to a greater extent than normal." [PomBase:mah] synonym: "increased agglutination involved in conjugation with cellular fusion" EXACT [GO:0000752] is_a: FYPO:0001872 ! abnormal cell adhesion is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: towards GO:0000752 ! agglutination involved in conjugation with cellular fusion relationship: towards GO:0000752 ! agglutination involved in conjugation with cellular fusion created_by: midori creation_date: 2013-01-09T15:41:12Z [Term] id: FYPO:0001872 name: abnormal cell adhesion def: "A cellular process phenotype in which adhesion of a cell to a substrate or another cell is abnormal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "adhesion defects" EXACT [PomBase:mah] is_a: FYPO:0000628 ! abnormal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0007155 ! cell adhesion intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0007155 ! cell adhesion relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-01-09T15:42:54Z [Term] id: FYPO:0001873 name: shmoo formation in absence of opposite mating type def: "A cellular process phenotype in which mating projection assembly takes place despite the absence of cells of the opposite mating type." [PMID:1905818, PomBase:mah] synonym: "conjugation tube formation in absence of opposite mating type" RELATED [PMID:1905818, PomBase:mah] synonym: "mating projection assembly in absence of opposite mating type" EXACT [PomBase:mah] synonym: "mating projection formation in absence of opposite mating type" EXACT [PomBase:mah] is_a: FYPO:0000568 ! abnormal shmoo formation created_by: midori creation_date: 2013-01-28T13:48:16Z [Term] id: FYPO:0001874 name: abnormal asymmetric protein localization to old or new mitotic spindle pole body def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the preferential localization of a protein to either the old or new spindle pole body is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found at the spindle pole body and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal asymmetric protein localisation to old or new mitotic spindle pole body" EXACT [PomBase:mah] synonym: "abnormal asymmetric protein localization to old or new mitotic SPB" EXACT [PomBase:mah] synonym: "abnormal asymmetric protein localization to old or new mitotic spindle pole body during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000939 ! abnormal protein localization to mitotic spindle pole body intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0061492 ! asymmetric protein localization to old or new spindle pole body intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0061492 ! asymmetric protein localization to old or new spindle pole body relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-01-30T11:45:04Z [Term] id: FYPO:0001875 name: decreased asymmetric protein localization to old or new mitotic spindle pole body def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the preferential localization of a protein to either the old or new spindle pole body is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased asymmetric protein localisation to old or new mitotic spindle pole body" EXACT [PomBase:mah] synonym: "decreased asymmetric protein localization to old or new mitotic SPB" EXACT [PomBase:mah] synonym: "decreased asymmetric protein localization to old or new mitotic spindle pole body during vegetative growth" EXACT [PomBase:mah] synonym: "reduced asymmetric protein localization to old or new mitotic spindle pole body" EXACT [PomBase:mah] is_a: FYPO:0000933 ! decreased protein localization to microtubule cytoskeleton during vegetative growth is_a: FYPO:0001874 ! abnormal asymmetric protein localization to old or new mitotic spindle pole body is_a: FYPO:0002770 ! decreased protein localization to spindle pole body intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0061492 ! asymmetric protein localization to old or new spindle pole body relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0061492 ! asymmetric protein localization to old or new spindle pole body created_by: midori creation_date: 2013-01-30T11:46:48Z [Term] id: FYPO:0001876 name: decreased asymmetric protein localization to old or new mitotic spindle pole body during anaphase, with protein symmetrically localized to both spindle pole bodies def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the preferential localization of a protein to either the old or new spindle pole body is decreased during mitotic anaphase, and the protein is instead symmetrically localized to both SPBs." [PMID:22119525, PMID:22419817, PMID:24920823, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormally symmetric protein localization to mitotic SPB during anaphase" EXACT [PomBase:mah] synonym: "abnormally symmetric protein localization to mitotic spindle pole bodies during anaphase" EXACT [PomBase:mah] synonym: "abnormally symmetric protein localization to spindle pole bodies during mitotic anaphase" EXACT [PomBase:mah] synonym: "abolished asymmetric protein localization to old or new mitotic SPB" RELATED [PomBase:mah] synonym: "decreased asymmetric protein localisation to old or new mitotic spindle pole body during anaphase, with protein symmetrically localised to both spindle pole bodies" EXACT [PomBase:mah] synonym: "decreased asymmetric protein localization to old or new mitotic spindle pole body during anaphase, with protein symmetrically localized to both spindle pole bodies, during vegetative growth" EXACT [PomBase:mah] synonym: "decreased asymmetric protein localization to old or new mitotic spindle pole body during mitotic anaphase, with protein symmetrically localized to both spindle pole bodies" EXACT [PomBase:mah] synonym: "reduced asymmetric protein localization to old or new mitotic spindle pole body during anaphase, with protein symmetrically localized to both spindle pole bodies" EXACT [PomBase:mah] is_a: FYPO:0001875 ! decreased asymmetric protein localization to old or new mitotic spindle pole body created_by: midori creation_date: 2013-01-30T11:47:20Z [Term] id: FYPO:0001877 name: viable thin vegetative cell def: "A cell morphology phenotype in which a vegetatively growing cell is viable but has an abnormally low thickness or diameter." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "thin viable vegetative cell" EXACT [PomBase:mah] synonym: "viable thin cell during vegetative growth" EXACT [PomBase:mah] synonym: "viable thin vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0002197 ! viable vegetative cell with abnormal cell shape intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0001491 ! viable vegetative cell intersection_of: has_part FYPO:0001879 ! thin cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0001491 ! viable vegetative cell relationship: has_part FYPO:0001879 ! thin cell created_by: midori creation_date: 2013-01-30T12:02:41Z [Term] id: FYPO:0001878 name: viable thin, elongated vegetative cell def: "A cell morphology phenotype in which a vegetatively growing cell is viable but is longer than normal and has an abnormally low thickness or diameter." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "thin, elongated viable cell during vegetative growth" EXACT [PomBase:mah] synonym: "thin, elongated viable vegetative cell" EXACT [PomBase:mah] synonym: "viable thin, elongated vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001492 ! viable elongated vegetative cell is_a: FYPO:0001877 ! viable thin vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0001491 ! viable vegetative cell intersection_of: has_part FYPO:0001879 ! thin cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0001491 ! viable vegetative cell relationship: has_part FYPO:0001879 ! thin cell created_by: midori creation_date: 2013-01-30T12:05:15Z [Term] id: FYPO:0001879 name: thin cell def: "A cell morphology phenotype in which a cell has an abnormally low thickness or diameter." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate is_a: FYPO:0001126 ! abnormal cell shape is_a: FYPO:0001127 ! abnormal cell size is_a: PATO:0000592 ! decreased thickness intersection_of: PATO:0000592 ! decreased thickness intersection_of: inheres_in CL:0000000 ! cell relationship: inheres_in CL:0000000 ! cell created_by: midori creation_date: 2013-01-30T12:06:48Z [Term] id: FYPO:0001880 name: abolished protein localization to cell division site def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the site of cell division is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to cell division site" EXACT [PomBase:mah] synonym: "abolished protein localization to cell division site during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to cell division site during vegetative growth" EXACT [PomBase:mah] synonym: "protein localization to cell division site abolished" EXACT [PomBase:mah] is_a: FYPO:0001179 ! protein localization abolished during vegetative growth is_a: FYPO:0001401 ! abnormal protein localization to cell division site intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0072741 ! protein localization to cell division site relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0072741 ! protein localization to cell division site created_by: midori creation_date: 2013-01-30T12:18:16Z [Term] id: FYPO:0001881 name: elongated actin filaments def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells form actin filaments that are longer than normal." [PomBase:mah] synonym: "elongated actin filaments during mitotic cell cycle" RELATED [PomBase:mah] synonym: "elongated actin filaments during vegetative growth" EXACT [PomBase:mah] synonym: "elongated microfilaments" RELATED [PomBase:mah] synonym: "long actin filaments" EXACT [PomBase:mah] is_a: FYPO:0000350 ! abnormal actin cytoskeleton morphology during vegetative growth is_a: PATO:0000573 ! increased length intersection_of: PATO:0000573 ! increased length intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005884 ! actin filament relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005884 ! actin filament created_by: midori creation_date: 2013-01-30T12:21:19Z [Term] id: FYPO:0001882 name: resistance to cell wall-degrading enzymes def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of one or more enzymes that degrades cell wall polysaccharides than normal." [PomBase:mah] synonym: "resistance to cell wall-degrading enzymes during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to cell wall-degrading enzymes during vegetative growth" EXACT [PomBase:mah] synonym: "resistance to Lyticase" NARROW [PomBase:mah] synonym: "resistance to Novozyme 234" NARROW [PomBase:mah] synonym: "resistance to Zymolyase" NARROW [PomBase:mah] synonym: "resistant to cell wall-degrading enzymes" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth created_by: midori creation_date: 2013-01-30T12:30:20Z [Term] id: FYPO:0001883 name: normal growth on caspofungin def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing caspofungin." [PomBase:mah] synonym: "normal cell population growth in presence of caspofungin" EXACT [PomBase:mah] synonym: "normal cell population growth on caspofungin" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cell population growth on glucan synthase inhibitor" BROAD [PomBase:mah] synonym: "normal cellular response to caspofungin" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on caspofungin" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:474180 ! caspofungin relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:474180 ! caspofungin created_by: midori creation_date: 2013-01-30T12:48:29Z [Term] id: FYPO:0001884 name: resistance to Calcofluor White def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of Calcofluor White than normal." [PomBase:mah] synonym: "resistance to Calcofluor White during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to Calcofluor White during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to Calcofluor White" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:50011 ! Calcofluor White relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:50011 ! Calcofluor White created_by: midori creation_date: 2013-01-30T12:50:20Z [Term] id: FYPO:0001885 name: decreased protein phosphorylation during salt stress def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal when the cell is subject to salt stress." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein phosphorylation during salt stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein phosphorylation during salt stress during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein phosphorylation during salt stress" EXACT [PomBase:mah] is_a: FYPO:0001838 ! decreased protein phosphorylation during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0071472 ! cellular response to salt stress intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0071472 ! cellular response to salt stress relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2013-01-30T12:58:39Z [Term] id: FYPO:0001886 name: meiosis and sporulation in haploid alt_id: FYPO:0001887 def: "A cellular process phenotype in which haploid cells undergo meiotic division and attempt to sporulate. Haploid meiosis often results in the formation of a structure that resembles an azygotic ascus. Spores produced from a haploid cell have poor viability and appear to contain only 1/2C DNA on average." [DOI:10.1007/BF00332932, PomBase:mah] synonym: "haploid meiosis" RELATED [PomBase:al] synonym: "haploid sporulation" RELATED [PomBase:al] synonym: "increased haploid meiosis" RELATED [PomBase:mah] synonym: "meiosis in haploid" RELATED [PomBase:mah] synonym: "sporulation in haploid" RELATED [PomBase:mah] is_a: FYPO:0000052 ! abnormal meiotic cell cycle created_by: midori creation_date: 2013-01-30T13:14:48Z [Term] id: FYPO:0001888 name: substance absent from cell def: "A cell phenotype in which the amount of a specific substance measured in a cell is too low to detect." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate is_a: FYPO:0000991 ! decreased level of substance in cell is_a: PATO:0002000 ! lacks all parts of type is_a: PATO:0002001 ! has fewer parts of type intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:24431 ! chemical entity relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:24431 ! chemical entity created_by: midori creation_date: 2013-01-30T15:19:23Z [Term] id: FYPO:0001889 name: RNA absent from cell def: "A cell phenotype in which the amount of RNA measured in a cell is too low to detect. Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [PomBase:mah] synonym: "transcripts absent from cell" EXACT [PomBase:vw] synonym: "undetectable cellular RNA level" EXACT [PomBase:al] is_a: FYPO:0000826 ! decreased RNA level is_a: FYPO:0001888 ! substance absent from cell intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:47600 ! purvalanol A relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:47600 ! purvalanol A created_by: midori creation_date: 2013-01-30T15:26:28Z [Term] id: FYPO:0001890 name: increased RNA level def: "A cell phenotype in which the amount of RNA measured in a cell is higher than normal. Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. subset: qc_do_not_manually_annotate synonym: "increased cellular mRNA level" NARROW [PomBase:vw] synonym: "increased cellular RNA level" EXACT [PomBase:mah] synonym: "increased RNA accumulation" RELATED [PomBase:mah] synonym: "increased transcript level" EXACT [PomBase:vw] synonym: "RNA accumulation: increased" RELATED [SGD:phenotype_annotation] is_a: FYPO:0000824 ! altered RNA level is_a: FYPO:0000990 ! increased level of substance in cell intersection_of: PATO:0001162 ! increased concentration intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:47600 ! purvalanol A relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:47600 ! purvalanol A created_by: midori creation_date: 2013-01-30T15:36:51Z [Term] id: FYPO:0001891 name: increased level of middle meiotic gene RNA during late meiosis def: "A cell phenotype observed in late meiosis in which the amount of RNA transcribed from middle meiotic genes measured in a cell is higher than normal. Middle meiotic genes are normally transcribed during meiotic division." [PomBase:al, PomBase:mah] synonym: "increased level of middle meiotic gene transcripts during late meiosis" EXACT [PomBase:vw] synonym: "increased RNA level of middle meiotic genes during late meiosis" EXACT [PomBase:al] is_a: FYPO:0001890 ! increased RNA level created_by: midori creation_date: 2013-01-30T15:43:26Z [Term] id: FYPO:0001892 name: decreased level of middle meiotic gene RNA during late meiosis def: "A cell phenotype observed in late meiosis in which the amount of RNA transcribed from middle meiotic genes measured in a cell is lower than normal. Middle meiotic genes are normally transcribed during meiotic division." [PomBase:al, PomBase:mah] synonym: "decreased level of middle meiotic gene transcripts during late meiosis" EXACT [PomBase:vw] synonym: "decreased RNA level of middle meiotic genes during late meiosis" EXACT [PomBase:al] synonym: "reduced level of middle meiotic gene RNA during late meiosis" EXACT [PomBase:mah] is_a: FYPO:0002959 ! decreased RNA level during meiosis created_by: midori creation_date: 2013-01-30T15:46:28Z [Term] id: FYPO:0001893 name: abnormal sporulation resulting in formation of azygotic ascus with more or fewer than four spores def: "A sporulation phenotype in which azygotic asci that contain more or fewer than four spores form following conjugation, diploid growth, and subsequent azygotic sporulation. Azygotic ascus formation occurs when meiosis takes place within a diploid cell rather than in a zygote produced by sporulation. Zygotes can resume vegetative growth and form colonies of diploid cells if returned to rich media before commitment to meiosis; under nitrogen starvation, diploid cells heterozygous for mating type will undergo azygotic meiosis. Azygotic asci have a characteristic linear morphology resembling that of a single vegetatively growing cell." [PMID:22558440, PomBase:mah] synonym: "abnormal sporulation resulting in formation of azygotic asci with more or fewer than four spores" EXACT [PomBase:mah] synonym: "sporulation defects, azygotic asci with more or fewer than four spores" EXACT [PomBase:mah] is_a: FYPO:0001894 ! abnormal sporulation resulting in formation of ascus with more or fewer than four spores created_by: midori creation_date: 2013-01-30T15:54:57Z [Term] id: FYPO:0001894 name: abnormal sporulation resulting in formation of ascus with more or fewer than four spores def: "A sporulation phenotype in which asci that contain more or fewer than four spores form following conjugation and subsequent sporulation." [PomBase:al, PomBase:mah] synonym: "abnormal ascospore formation resulting in formation of asci with more or fewer than four spores" EXACT [GO:0030437, PomBase:mah] synonym: "abnormal spore number" EXACT [PomBase:vw] synonym: "abnormal sporulation resulting in formation of asci with more or fewer than four spores" EXACT [PomBase:mah] is_a: FYPO:0000121 ! abnormal sporulation created_by: midori creation_date: 2013-01-30T15:57:25Z [Term] id: FYPO:0001895 name: P-bodies present in greater numbers def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells contain more cytoplasmic mRNA processing bodies (P-bodies) than normal." [PomBase:mah] synonym: "additional P-bodies present" EXACT [PomBase:mah] synonym: "cytoplasmic mRNA processing bodies present in greater numbers" EXACT [GO:0000932] synonym: "enhanced P-body formation" RELATED [PomBase:al] synonym: "extra P-bodies" EXACT [PomBase:mah] synonym: "P bodies present in greater numbers" EXACT [GO:0000932] synonym: "P-bodies present in greater numbers during mitotic cell cycle" RELATED [PomBase:mah] synonym: "P-bodies present in greater numbers during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: PATO:0002002 ! has extra parts of type intersection_of: PATO:0002002 ! has extra parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0000932 ! cytoplasmic mRNA processing body relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0000932 ! cytoplasmic mRNA processing body created_by: midori creation_date: 2013-01-30T16:38:10Z [Term] id: FYPO:0001896 name: enlarged P-bodies def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cytoplasmic mRNA processing bodies (P-bodies) are larger than normal." [PomBase:mah] synonym: "enhanced P-body formation" RELATED [PomBase:al] synonym: "enlarged cytoplasmic mRNA processing bodies" EXACT [GO:0000932] synonym: "enlarged P bodies" EXACT [GO:0000932] synonym: "enlarged P-bodies during mitotic cell cycle" RELATED [PomBase:mah] synonym: "enlarged P-bodies during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: PATO:0000586 ! increased size intersection_of: PATO:0000586 ! increased size intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000932 ! cytoplasmic mRNA processing body relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000932 ! cytoplasmic mRNA processing body created_by: midori creation_date: 2013-01-30T16:40:40Z [Term] id: FYPO:0001897 name: P-bodies present in decreased numbers during vegetative growth def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells contain fewer cytoplasmic mRNA processing bodies (P-bodies) than normal." [PomBase:mah] synonym: "cytoplasmic mRNA processing bodies present in decreased numbers during vegetative growth" EXACT [GO:0000932] synonym: "decreased P-body formation during vegetative growth" RELATED [PomBase:al] synonym: "fewer P-bodies present during vegetative growth" EXACT [PomBase:mah] synonym: "P bodies present in decreased numbers during vegetative growth" EXACT [GO:0000932] synonym: "P-bodies present in decreased numbers during mitotic cell cycle" RELATED [PomBase:mah] synonym: "P-bodies present in reduced numbers during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: FYPO:0001898 ! P-bodies present in decreased numbers intersection_of: PATO:0002001 ! has fewer parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0000932 ! cytoplasmic mRNA processing body relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0000932 ! cytoplasmic mRNA processing body created_by: midori creation_date: 2013-01-30T16:59:10Z [Term] id: FYPO:0001898 name: P-bodies present in decreased numbers def: "A physical cellular phenotype in which cells contain fewer cytoplasmic mRNA processing bodies (P-bodies) than normal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "cytoplasmic mRNA processing bodies present in decreased numbers" EXACT [GO:0000932] synonym: "decreased P-body formation" RELATED [PomBase:al] synonym: "fewer P-bodies present" EXACT [PomBase:mah] synonym: "P bodies present in decreased numbers" EXACT [GO:0000932] synonym: "P-bodies present in reduced numbers" EXACT [PomBase:mah] is_a: FYPO:0000287 ! abnormal subcellular component is_a: PATO:0002001 ! has fewer parts of type intersection_of: PATO:0002001 ! has fewer parts of type intersection_of: towards GO:0000932 ! cytoplasmic mRNA processing body relationship: towards GO:0000932 ! cytoplasmic mRNA processing body created_by: midori creation_date: 2013-01-30T16:59:23Z [Term] id: FYPO:0001899 name: P-bodies present in decreased numbers during glucose starvation def: "A physical cellular phenotype in which cells contain fewer cytoplasmic mRNA processing bodies (P-bodies) than normal when the cell is subject to glucose starvation." [PomBase:mah] synonym: "cytoplasmic mRNA processing bodies present in decreased numbers during glucose starvation" EXACT [GO:0000932] synonym: "decreased P-body formation during glucose starvation" RELATED [PomBase:al] synonym: "fewer P-bodies present during glucose starvation" EXACT [PomBase:mah] synonym: "P bodies present in decreased numbers during glucose starvation" EXACT [GO:0000932] synonym: "P-bodies present in decreased numbers during glucose depletion" EXACT [PomBase:vw] synonym: "P-bodies present in decreased numbers during glucose deprivation" EXACT [PomBase:vw] synonym: "P-bodies present in reduced numbers during glucose starvation" EXACT [PomBase:mah] is_a: FYPO:0001898 ! P-bodies present in decreased numbers intersection_of: PATO:0002001 ! has fewer parts of type intersection_of: exists_during GO:0042149 ! cellular response to glucose starvation intersection_of: towards GO:0000932 ! cytoplasmic mRNA processing body relationship: exists_during GO:0042149 ! cellular response to glucose starvation relationship: towards GO:0000932 ! cytoplasmic mRNA processing body created_by: midori creation_date: 2013-01-30T17:03:35Z [Term] id: FYPO:0001900 name: small P-bodies def: "A physical cellular phenotype in which cytoplasmic mRNA processing bodies (P-bodies) are smaller than normal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "decreased P-body formation" RELATED [PomBase:al] synonym: "small cytoplasmic mRNA processing bodies" EXACT [GO:0000932] synonym: "small P bodies" EXACT [GO:0000932] is_a: FYPO:0000287 ! abnormal subcellular component is_a: PATO:0000596 ! decreased volume intersection_of: PATO:0000596 ! decreased volume intersection_of: inheres_in GO:0000932 ! cytoplasmic mRNA processing body relationship: inheres_in GO:0000932 ! cytoplasmic mRNA processing body created_by: midori creation_date: 2013-01-30T17:07:32Z [Term] id: FYPO:0001901 name: small P-bodies during vegetative growth def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cytoplasmic mRNA processing bodies (P-bodies) are smaller than normal." [PomBase:mah] synonym: "decreased P-body formation during vegetative growth" RELATED [PomBase:al] synonym: "small cytoplasmic mRNA processing bodies during vegetative growth" EXACT [GO:0000932] synonym: "small P bodies during vegetative growth" EXACT [GO:0000932] synonym: "small P-bodies during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: FYPO:0001900 ! small P-bodies intersection_of: PATO:0000596 ! decreased volume intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000932 ! cytoplasmic mRNA processing body relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000932 ! cytoplasmic mRNA processing body created_by: midori creation_date: 2013-01-30T17:07:49Z [Term] id: FYPO:0001902 name: small P-bodies during glucose starvation def: "A physical cellular phenotype in which cytoplasmic mRNA processing bodies (P-bodies) are smaller than normal when the cell is subject to glucose starvation." [PomBase:mah] synonym: "decreased P-body formation during glucose starvation" RELATED [PomBase:al] synonym: "small cytoplasmic mRNA processing bodies during glucose starvation" EXACT [GO:0000932] synonym: "small P bodies during glucose starvation" EXACT [GO:0000932] synonym: "small P-bodies during glucose depletion" EXACT [PomBase:vw] synonym: "small P-bodies during glucose deprivation" EXACT [PomBase:vw] is_a: FYPO:0001900 ! small P-bodies intersection_of: PATO:0000596 ! decreased volume intersection_of: exists_during GO:0042149 ! cellular response to glucose starvation intersection_of: inheres_in GO:0000932 ! cytoplasmic mRNA processing body relationship: exists_during GO:0042149 ! cellular response to glucose starvation relationship: inheres_in GO:0000932 ! cytoplasmic mRNA processing body created_by: midori creation_date: 2013-01-30T17:12:02Z [Term] id: FYPO:0001903 name: normal septation index def: "A cell population phenotype in which the septation index is normal (i.e. indistinguishable from wild type). The septation index is the proportion of the population undergoing septation at any given time, and is usually around 10% (varying between 7-15%) for vegetatively growing wild type cell populations, and less for stationary populations." [PomBase:mah, PomBase:vw] synonym: "normal septation" RELATED [PomBase:mah] is_a: FYPO:0000003 ! cell population phenotype is_a: FYPO:0000257 ! normal phenotype created_by: midori creation_date: 2013-01-30T17:14:13Z [Term] id: FYPO:0001904 name: premature actomyosin contractile ring disassembly def: "A cytokinesis phenotype observed in the vegetative growth phase of the life cycle in which the contractile ring collapses or disassembles upon initiation of contraction during anaphase B. Septum formation typically does not occur in cells in which the contractile ring has collapsed." [PMID:22174761, PomBase:mah] synonym: "abnormal contractile ring contraction with contractile ring collapse" EXACT [PomBase:mah] synonym: "actomyosin contractile ring collapse" EXACT [PomBase:mah] synonym: "actomyosin contractile ring collapse upon contraction" EXACT [PomBase:mah] synonym: "actomyosin contractile ring disassembly before septation" EXACT [PomBase:vw] synonym: "advanced actomyosin contractile ring disassembly" EXACT [PomBase:mah] synonym: "cytokinesis defects, collapse of the actinomyosin ring" RELATED [PomBase:mah] synonym: "premature actomyosin contractile ring disassembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "premature actomyosin contractile ring disassembly during vegetative growth" EXACT [PomBase:mah] synonym: "premature cytokinetic contractile ring disassembly" EXACT [PomBase:vw] synonym: "premature mitotic contractile ring disassembly" EXACT [PomBase:vw] is_a: FYPO:0000032 ! abnormal cytokinesis is_a: PATO:0000694 ! premature intersection_of: PATO:0000694 ! premature intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902621 ! actomyosin contractile ring disassembly relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902621 ! actomyosin contractile ring disassembly created_by: midori creation_date: 2013-01-30T17:33:34Z [Term] id: FYPO:0001905 name: normal mitotic spindle microtubules def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the number, structure, and orientation of microtubules in the mitotic spindle are normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal mitotic spindle microtubules during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001313 ! normal subcellular component during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: exists_during GO:0007067 ! mitotic nuclear division intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005876 ! spindle microtubule intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0007067 ! mitotic nuclear division relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005876 ! spindle microtubule relationship: part_of FYPO:0001399 ! normal mitotic spindle relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-01-30T17:47:11Z [Term] id: FYPO:0001906 name: abnormal cellular response to thiamine starvation def: "A stress response phenotype observed in the vegetative growth phase of the life cycle in which the response to thiamine starvation is abnormal." [PomBase:mah] synonym: "abnormal cellular response to thiamin starvation" EXACT [GO:0036225] synonym: "abnormal cellular response to thiamine depletion" EXACT [PomBase:vw] synonym: "abnormal cellular response to thiamine deprivation" EXACT [PomBase:vw] synonym: "abnormal cellular response to thiamine starvation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal cellular response to thiamine starvation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal cellular response to vitamin B1 starvation" EXACT [GO:0036225] is_a: FYPO:0001339 ! abnormal cellular response to starvation during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0036225 ! cellular response to vitamin B1 starvation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0036225 ! cellular response to vitamin B1 starvation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-01-31T14:27:28Z [Term] id: FYPO:0001907 name: growth auxotrophic for thiamine def: "Auxotrophy in which a cell is unable to synthesize thiamine, and therefore requires thiamine in the medium for vegetative cell growth." [PomBase:mah] synonym: "growth auxotrophic for thiamin" EXACT [GO:0036225, PomBase:mah] synonym: "growth auxotrophic for thiamine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "growth auxotrophic for thiamine during vegetative growth" EXACT [PomBase:mah] synonym: "growth auxotrophic for vitamin B1" EXACT [GO:0036225] synonym: "thiamine auxotrophy" EXACT [PomBase:mah] is_a: FYPO:0000128 ! auxotrophy is_a: PATO:0000422 ! auxotrophic intersection_of: PATO:0000422 ! auxotrophic intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:26948 ! thiamine relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:26948 ! thiamine created_by: midori creation_date: 2013-01-31T14:27:37Z [Term] id: FYPO:0001908 name: increased pre-mRNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of any unspliced or incompletely spliced mRNA precursor measured in a cell is higher than normal." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "accumulation of pre-mRNA transcripts" RELATED [PomBase:vw] synonym: "increased pre-mRNA accumulation" RELATED [PomBase:mah] synonym: "increased pre-mRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased pre-mRNA level during vegetative growth" EXACT [PomBase:mah] synonym: "increased pre-mRNA transcript level" EXACT [PomBase:vw] is_a: FYPO:0000825 ! increased RNA level during vegetative growth relationship: output_of FYPO:0003029 ! decreased mRNA splicing, via spliceosome created_by: midori creation_date: 2013-02-06T11:39:09Z [Term] id: FYPO:0001909 name: normal protein glycosylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which protein glycosylation is normal (i.e. indistinguishable from wild type). Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid." [GO:0006486, PomBase:mah] synonym: "normal protein glycosylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein glycosylation during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein/peptide glycosylation" EXACT [PomBase:mah] is_a: FYPO:0000549 ! normal protein modification during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006486 ! protein glycosylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006486 ! protein glycosylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-01-31T14:53:52Z [Term] id: FYPO:0001910 name: abnormal protein glycosylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the glycosylation of one or more specific proteins, or of specific protein sites, is abnormal. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein glycosylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein glycosylation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000329 ! abnormal protein modification during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006486 ! protein glycosylation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006486 ! protein glycosylation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-01-31T14:55:43Z [Term] id: FYPO:0001911 name: decreased protein glycosylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the glycosylation of one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal. Protein glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid." [GO:0006486, PomBase:mah] synonym: "decreased protein glycosylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein glycosylation during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein glycosylation" EXACT [PomBase:mah] is_a: FYPO:0000545 ! decreased protein modification during vegetative growth is_a: FYPO:0001910 ! abnormal protein glycosylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006486 ! protein glycosylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006486 ! protein glycosylation created_by: midori creation_date: 2013-01-31T14:55:50Z [Term] id: FYPO:0001912 name: abnormal ubiquitin ligase activity def: "A molecular function phenotype in which the observed rate of ubiquitin ligase activity is abnormal." [PomBase:mah] synonym: "abnormal ubiquitin-protein ligase activity" EXACT [GO:0004842] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004842 ! ubiquitin-protein transferase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004842 ! ubiquitin-protein transferase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-01-31T15:09:44Z [Term] id: FYPO:0001913 name: abolished ubiquitin ligase activity def: "A molecular function phenotype in which ubiquitin ligase activity is absent." [PomBase:mah] synonym: "abolished ubiquitin-protein ligase activity" EXACT [GO:0004842] synonym: "ubiquitin ligase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0001912 ! abnormal ubiquitin ligase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0004842 ! ubiquitin-protein transferase activity relationship: towards GO:0004842 ! ubiquitin-protein transferase activity created_by: midori creation_date: 2013-01-31T15:09:55Z [Term] id: FYPO:0001914 name: abnormal prospore membrane formation def: "A cellular process phenotype in which prospore formation assembly is abnormal. In prospore formation, the nascent membrane forms at the meiotic outer plaque and grows until closure occurs and forespores, or prospores, are formed." [GO:0032120, PomBase:mah] synonym: "abnormal ascospore-type prospore membrane assembly" EXACT [GO:0032120] synonym: "abnormal forespore membrane formation" EXACT [PomBase:mah] is_a: FYPO:0000336 ! abnormal cellular component assembly is_a: FYPO:0000679 ! developmental process phenotype is_a: FYPO:0001013 ! abnormal membrane organization is_a: FYPO:0002739 ! abnormal meiotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0032120 ! ascospore-type prospore membrane assembly intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0032120 ! ascospore-type prospore membrane assembly relationship: part_of FYPO:0000196 ! abnormal prospore formation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-01-31T15:42:32Z [Term] id: FYPO:0001915 name: abolished prospore membrane formation def: "A cellular process phenotype in which forespore membrane formation does not occur." [PomBase:mah] synonym: "abolished ascospore-type prospore membrane assembly" EXACT [GO:0032120] synonym: "abolished forespore membrane formation" EXACT [GO:0032120] synonym: "prospore membrane formation abolished" EXACT [PomBase:mah] is_a: FYPO:0001914 ! abnormal prospore membrane formation is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0032120 ! ascospore-type prospore membrane assembly relationship: towards GO:0032120 ! ascospore-type prospore membrane assembly created_by: midori creation_date: 2013-01-31T15:47:54Z [Term] id: FYPO:0001916 name: elongated mononucleate vegetative cell def: "A cell phenotype in which a cell contains one nucleus apiece and is elongated." [PomBase:mah] synonym: "elongated mononucleate cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "elongated mononucleate cell during vegetative growth" EXACT [PomBase:mah] synonym: "long mononucleate cell" EXACT [PomBase:vw] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000060 ! mononucleate vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000060 ! mononucleate vegetative cell created_by: midori creation_date: 2013-02-06T11:57:40Z [Term] id: FYPO:0001917 name: elongated mononucleate monoseptate vegetative cell def: "A cell phenotype in which a cell contains a single septum, has one nucleus in the septated cell, and is elongated." [PomBase:mah] synonym: "elongated mononucleate monoseptate cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "elongated mononucleate monoseptate cell during vegetative growth" EXACT [PomBase:mah] synonym: "long monoseptate mononucleate cell" EXACT [PomBase:vw] is_a: FYPO:0001916 ! elongated mononucleate vegetative cell is_a: FYPO:0004750 ! elongated septated vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000060 ! mononucleate vegetative cell intersection_of: has_part FYPO:0001225 ! monoseptate relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000060 ! mononucleate vegetative cell relationship: has_part FYPO:0001225 ! monoseptate created_by: midori creation_date: 2013-02-06T12:00:33Z [Term] id: FYPO:0001918 name: normal growth on trifluoperazine def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing trifluoperazine." [PomBase:mah] synonym: "normal cell population growth in presence of trifluoperazine" EXACT [PomBase:mah] synonym: "normal cell population growth on trifluoperazine" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to trifluoperazine" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on trifluoperazine" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:45951 ! trifluoperazine relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:45951 ! trifluoperazine created_by: midori creation_date: 2013-02-06T12:08:16Z [Term] id: FYPO:0001919 name: fragmented nucleus def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the nucleus is broken into multiple small fragments that are smaller than a normal nucleus." [PomBase:mah] synonym: "fragmented nucleus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "fragmented nucleus during vegetative growth" EXACT [PomBase:mah] synonym: "loss of nuclear integrity" RELATED [PomBase:al] is_a: FYPO:0000062 ! abnormal nuclear morphology during vegetative growth is_a: PATO:0001444 ! broken intersection_of: PATO:0001444 ! broken intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005634 ! nucleus relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005634 ! nucleus created_by: midori creation_date: 2013-02-06T14:32:47Z [Term] id: FYPO:0001920 name: decreased protein export from nucleus def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of protein export from nucleus is decreased. Export of all proteins or a specific protein may be affected." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein export from nucleus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein export from nucleus during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein export from nucleus" EXACT [PomBase:mah] is_a: FYPO:0000345 ! abnormal protein export from nucleus is_a: FYPO:0000508 ! decreased nuclear export is_a: FYPO:0000541 ! decreased protein transport intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006611 ! protein export from nucleus relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006611 ! protein export from nucleus created_by: midori creation_date: 2013-02-06T14:35:44Z [Term] id: FYPO:0001921 name: abolished protein export from nucleus def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which protein export from the nucleus does not occur. Export of all proteins or a specific protein may be affected." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein export from nucleus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "absent protein export from nucleus" EXACT [PomBase:mah] synonym: "protein export from nucleus abolished" EXACT [PomBase:mah] synonym: "protein export from nucleus abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000345 ! abnormal protein export from nucleus is_a: FYPO:0000507 ! abolished nuclear export intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0006611 ! protein export from nucleus relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0006611 ! protein export from nucleus created_by: midori creation_date: 2013-02-06T14:37:54Z [Term] id: FYPO:0001922 name: normal protein dephosphorylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which protein dephosphorylation is normal (i.e. indistinguishable from wild type). Protein dephosphorylation is the removal of a phosphate group from a protein amino acid." [GO:0006470, PomBase:mah] synonym: "normal protein dephosphorylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein dephosphorylation during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein/peptide dephosphorylation" EXACT [PomBase:mah] is_a: FYPO:0000549 ! normal protein modification during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006470 ! protein dephosphorylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006470 ! protein dephosphorylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-02-06T14:58:05Z [Term] id: FYPO:0001923 name: normal protein dephosphorylation during mitotic G2/M transition def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which protein dephosphorylation is normal (i.e. indistinguishable from wild type) during the G2/M phase transition of the mitotic cell cycle. Protein dephosphorylation is the removal of a phosphate group from a protein amino acid." [GO:0006470, PomBase:mah] synonym: "normal protein dephosphorylation during G2/M phase transition" EXACT [PomBase:al] synonym: "normal protein dephosphorylation during G2/M transition during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein dephosphorylation during G2/M transition of mitotic cell cycle" EXACT [PomBase:mah] synonym: "normal protein/peptide dephosphorylation during mitotic G2/M transition" EXACT [PomBase:mah] is_a: FYPO:0001922 ! normal protein dephosphorylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0000086 ! G2/M transition of mitotic cell cycle intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006470 ! protein dephosphorylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0000086 ! G2/M transition of mitotic cell cycle relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006470 ! protein dephosphorylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-02-06T15:00:26Z [Term] id: FYPO:0001924 name: inviable after spore germination, without cell division, cell cycle arrest def: "A phenotype in which a spore germinates to produce a cell that enters the cell cycle but then undergoes cell cycle arrest, and eventually dies without completing cell division." [PomBase:mah] synonym: "essential; germinating spore, without cell division, cell cycle arrest" RELATED [PomBase:mah] synonym: "inviable following spore germination, without cell division, cell cycle arrest" EXACT [PomBase:mah] synonym: "inviable germinated spore, without cell division, cell cycle arrest" EXACT [PomBase:mah] is_a: FYPO:0001991 ! inviable after spore germination, without cell division intersection_of: FYPO:0000316 ! inviable after spore germination intersection_of: has_part FYPO:0000407 ! abnormally arrested cell cycle progression relationship: has_part FYPO:0000407 ! abnormally arrested cell cycle progression created_by: midori creation_date: 2013-02-06T15:14:31Z [Term] id: FYPO:0001925 name: normal cellular response to gamma radiation def: "A cellular response phenotype observed in the vegetative growth phase of the life cycle in which the cellular response to gamma radiation is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular response to gamma radiation" EXACT [PomBase:mah] synonym: "normal cellular response to gamma radiation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular response to gamma radiation during vegetative growth" EXACT [PomBase:mah] synonym: "normal sensitivity to gamma radiation" EXACT [PomBase:vw] is_a: FYPO:0000968 ! normal cellular response to stress intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071480 ! cellular response to gamma radiation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071480 ! cellular response to gamma radiation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-02-06T15:19:50Z [Term] id: FYPO:0001926 name: normal cellular response to hydroxyurea def: "A cellular response phenotype observed in the vegetative growth phase of the life cycle in which the cellular response to hydroxyurea is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: Note: Use this term only if a specific response, such as cell cycle delay, is measured. If only cell growth in the presence of hydroxyurea is assayed, use 'normal cell population growth on hydroxyurea' (FYPO:000063). synonym: "normal cellular response to HU" EXACT [GO:0071280] synonym: "normal cellular response to hydroxyurea during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular response to hydroxyurea during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001318 ! normal cellular response to chemical stimulus during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072711 ! cellular response to hydroxyurea intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072711 ! cellular response to hydroxyurea relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-02-06T15:26:30Z [Term] id: FYPO:0001927 name: normal cell cycle regulation during cellular response to ionizing radiation def: "A cellular response phenotype observed in the vegetative growth phase of the life cycle in which the regulation of the mitotic cell cycle in response to ionizing radiation is normal (i.e. indistinguishable from wild type). Normally, cell cycle progression is slowed or arrested transiently following exposure to ionizing radiation." [PomBase:mah] synonym: "normal cell cycle delay following ionizing radiation" EXACT [PomBase:al] synonym: "normal cell cycle regulation during cellular response to gamma radiation" NARROW [PomBase:al, PomBase:mah] synonym: "normal cell cycle regulation during cellular response to ionizing radiation during vegetative growth" EXACT [PomBase:mah] synonym: "normal cell cycle regulation in response to ionizing radiation" EXACT [PomBase:mah] synonym: "normal mitotic cell cycle regulation during cellular response to ionizing radiation" EXACT [PomBase:mah] is_a: FYPO:0001928 ! normal regulation of mitotic cell cycle intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0071480 ! cellular response to gamma radiation intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0007346 ! regulation of mitotic cell cycle intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0071480 ! cellular response to gamma radiation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0007346 ! regulation of mitotic cell cycle relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-02-06T15:30:14Z [Term] id: FYPO:0001928 name: normal regulation of mitotic cell cycle def: "A regulation phenotype in which regulation of the mitotic cell cycle is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cell cycle regulation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000411 ! normal mitotic cell cycle is_a: FYPO:0001334 ! regulation phenotype during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0007346 ! regulation of mitotic cell cycle intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0007346 ! regulation of mitotic cell cycle relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-02-06T15:31:52Z [Term] id: FYPO:0001929 name: normal cell cycle regulation during cellular response to hydroxyurea def: "A cellular response phenotype observed in the vegetative growth phase of the life cycle in which the regulation of the mitotic cell cycle in response to hydroxyurea is normal (i.e. indistinguishable from wild type). Normally, cell cycle progression is slowed or arrested transiently following exposure to hydroxyurea." [PomBase:mah] synonym: "normal cell cycle arrest in response to HU" NARROW [PMID:1706223, PomBase:al] synonym: "normal cell cycle delay following hydroxyurea exposure" NARROW [PomBase:al] synonym: "normal cell cycle regulation during cellular response to HU" EXACT [PomBase:mah] synonym: "normal cell cycle regulation during cellular response to hydroxyurea during vegetative growth" EXACT [PomBase:mah] synonym: "normal cell cycle regulation in response to hydroxyurea" EXACT [PomBase:mah] synonym: "normal mitotic cell cycle regulation during cellular response to hydroxyurea" EXACT [PomBase:mah] is_a: FYPO:0001926 ! normal cellular response to hydroxyurea is_a: FYPO:0001928 ! normal regulation of mitotic cell cycle intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: happens_during GO:0072711 ! cellular response to hydroxyurea intersection_of: inheres_in GO:0007346 ! regulation of mitotic cell cycle intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: happens_during GO:0072711 ! cellular response to hydroxyurea relationship: inheres_in GO:0007346 ! regulation of mitotic cell cycle relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-02-06T15:43:31Z [Term] id: FYPO:0001930 name: abnormal cellular response to gamma radiation def: "A cellular response phenotype observed in the vegetative growth phase of the life cycle in which the cellular response to gamma radiation is abnormal." [PomBase:mah] synonym: "abnormal cellular response to gamma radiation" EXACT [PomBase:mah] synonym: "abnormal cellular response to gamma radiation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal cellular response to gamma radiation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal sensitivity to gamma radiation" EXACT [PomBase:vw] is_a: FYPO:0001341 ! abnormal cellular response to stress during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0071480 ! cellular response to gamma radiation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0071480 ! cellular response to gamma radiation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-02-06T15:55:54Z [Term] id: FYPO:0001931 name: abnormal cell cycle regulation during cellular response to gamma radiation def: "A cellular response phenotype observed in the vegetative growth phase of the life cycle in which the regulation of the mitotic cell cycle in response to gamma radiation is abnormal. Normally, cell cycle progression is slowed or arrested transiently following exposure to gamma radiation. The most common abnormality is for the cell cycle to progress as in the absence of gamma radiation." [PomBase:mah] synonym: "abnormal cell cycle delay following gamma radiation" EXACT [PomBase:al] synonym: "abnormal cell cycle regulation in response to gamma radiation" EXACT [PomBase:mah] synonym: "abnormal mitotic cell cycle regulation during cellular response to gamma radiation" EXACT [PomBase:mah] is_a: FYPO:0001930 ! abnormal cellular response to gamma radiation is_a: FYPO:0003489 ! abnormal mitotic cell cycle regulation during cellular response to ionizing radiation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0071480 ! cellular response to gamma radiation intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0007346 ! regulation of mitotic cell cycle intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0071480 ! cellular response to gamma radiation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0007346 ! regulation of mitotic cell cycle relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-02-06T15:56:28Z [Term] id: FYPO:0001932 name: abnormal cellular response to hydroxyurea def: "A cellular response phenotype observed in the vegetative growth phase of the life cycle in which the cellular response to hydroxyurea is abnormal." [PomBase:mah] comment: Note: Use this term only if a specific response, such as cell cycle delay, is measured. If only cell growth in the presence of hydroxyurea is assayed, use 'sensitive to hydroxyurea' (FYPO:0000088) if applicable. synonym: "abnormal cellular response to HU" EXACT [GO:0071280] synonym: "abnormal cellular response to hydroxyurea during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal cellular response to hydroxyurea during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001342 ! cellular response phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0072711 ! cellular response to hydroxyurea intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0072711 ! cellular response to hydroxyurea relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-02-06T16:01:04Z [Term] id: FYPO:0001933 name: abnormal mitotic cell cycle regulation during cellular response to hydroxyurea def: "A cellular response phenotype observed in the vegetative growth phase of the life cycle in which the regulation of the mitotic cell cycle in response to hydroxyurea is abnormal. Normally, cell cycle progression is slowed or arrested transiently following exposure to hydroxyurea. The most common abnormality is for the cell cycle to progress as in the absence of hydroxyurea." [PomBase:mah] synonym: "abnormal cell cycle regulation during cellular response to hydroxyurea" EXACT [PomBase:mah] synonym: "abnormal mitotic cell cycle delay following hydroxyurea exposure" EXACT [PomBase:al] synonym: "abnormal mitotic cell cycle regulation during cellular response to HU" EXACT [PomBase:mah] synonym: "abnormal mitotic cell cycle regulation in response to hydroxyurea" EXACT [PomBase:mah] is_a: FYPO:0000148 ! abnormal regulation of mitotic cell cycle is_a: FYPO:0001932 ! abnormal cellular response to hydroxyurea intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: happens_during GO:0072711 ! cellular response to hydroxyurea intersection_of: inheres_in_part_of GO:0007346 ! regulation of mitotic cell cycle intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: happens_during GO:0072711 ! cellular response to hydroxyurea relationship: inheres_in_part_of GO:0007346 ! regulation of mitotic cell cycle relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-02-06T16:01:24Z [Term] id: FYPO:0001934 name: abolished cell population growth on glycerol carbon source def: "A vegetative cell population growth phenotype in which a cell population does not grow in a medium containing glycerol as the carbon source." [PomBase:mah] comment: Use this term for a population of cells that does not grow with glycerol as the carbon source, but does grow using a different carbon source (a cell population that does not grow on any media would be considered inviable). Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "abolished glycerol utilization" RELATED [PomBase:mah, PomBase:vw] synonym: "abolished growth on glycerol carbon source" BROAD [PomBase:mah] synonym: "abolished vegetative cell population growth on glycerol carbon source" EXACT [PomBase:mah] synonym: "cell population growth on glycerol carbon source abolished" EXACT [PomBase:mah] is_a: FYPO:0000684 ! decreased cell population growth on glycerol carbon source is_a: FYPO:0001575 ! abolished vegetative cell population growth intersection_of: FYPO:0001575 ! abolished vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:17754 ! glycerol relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:17754 ! glycerol created_by: midori creation_date: 2013-02-06T16:08:06Z [Term] id: FYPO:0001935 name: abnormal hydrogen ion transporting ATP synthase activity, rotational mechanism def: "A molecular function phenotype in which the observed rate of hydrogen ion transporting ATP synthase activity by a rotational mechanism is abnormal." [PomBase:mah] synonym: "abnormal hydrogen ion transporting ATP synthase activity" RELATED [PomBase:mah] synonym: "abnormal mitochondrial hydrogen ion transporting ATP synthase activity" NARROW [PomBase:vw] is_a: FYPO:0001167 ! abnormal ATPase activity is_a: FYPO:0002116 ! abnormal transporter activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0046933 ! proton-transporting ATP synthase activity, rotational mechanism intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0046933 ! proton-transporting ATP synthase activity, rotational mechanism relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-02-06T16:22:30Z [Term] id: FYPO:0001936 name: decreased hydrogen ion transporting ATP synthase activity, rotational mechanism def: "A molecular function phenotype in which the observed rate of hydrogen ion transporting ATP synthase activity by a rotational mechanism is decreased." [PomBase:mah] synonym: "decreased hydrogen ion transporting ATP synthase activity" RELATED [PomBase:mah] synonym: "decreased mitochondrial hydrogen ion transporting ATP synthase activity" NARROW [PomBase:vw] synonym: "reduced hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [PomBase:mah] synonym: "reduced mitochondrial hydrogen ion transporting ATP synthase activity" NARROW [PomBase:vw] is_a: FYPO:0001168 ! decreased ATPase activity is_a: FYPO:0001935 ! abnormal hydrogen ion transporting ATP synthase activity, rotational mechanism is_a: FYPO:0002118 ! decreased transporter activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0046933 ! proton-transporting ATP synthase activity, rotational mechanism relationship: inheres_in GO:0046933 ! proton-transporting ATP synthase activity, rotational mechanism created_by: midori creation_date: 2013-02-06T16:22:37Z [Term] id: FYPO:0001937 name: abnormal cytochrome-c oxidase activity def: "A molecular function phenotype in which the observed rate of cytochrome-c oxidase activity is abnormal." [PomBase:mah] comment: Also consider using the cellular process phenotype term 'abnormal cellular respiration' (FYPO:0000078). is_a: FYPO:0000689 ! abnormal oxidoreductase activity is_a: FYPO:0002116 ! abnormal transporter activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004129 ! cytochrome-c oxidase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004129 ! cytochrome-c oxidase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-02-06T16:26:21Z [Term] id: FYPO:0001938 name: decreased cytochrome-c oxidase activity def: "A molecular function phenotype in which the observed rate of cytochrome-c oxidase activity is decreased." [PomBase:mah] comment: Also consider using the cellular process phenotype term 'decreased cellular respiration' (FYPO:0000342). synonym: "reduced cytochrome-c oxidase activity" EXACT [PomBase:mah] is_a: FYPO:0000690 ! decreased oxidoreductase activity is_a: FYPO:0001937 ! abnormal cytochrome-c oxidase activity is_a: FYPO:0002118 ! decreased transporter activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004129 ! cytochrome-c oxidase activity relationship: inheres_in GO:0004129 ! cytochrome-c oxidase activity created_by: midori creation_date: 2013-02-06T16:26:27Z [Term] id: FYPO:0001939 name: abnormal ubiquinol-cytochrome-c reductase activity def: "A molecular function phenotype in which the observed rate of ubiquinol-cytochrome-c reductase activity is abnormal." [PomBase:mah] is_a: FYPO:0000689 ! abnormal oxidoreductase activity is_a: FYPO:0002116 ! abnormal transporter activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0008121 ! ubiquinol-cytochrome-c reductase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0008121 ! ubiquinol-cytochrome-c reductase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-02-06T16:37:49Z [Term] id: FYPO:0001940 name: decreased ubiquinol-cytochrome-c reductase activity def: "A molecular function phenotype in which the observed rate of ubiquinol-cytochrome-c reductase activity is decreased." [PomBase:mah] synonym: "reduced ubiquinol-cytochrome-c reductase activity" EXACT [PomBase:mah] is_a: FYPO:0000690 ! decreased oxidoreductase activity is_a: FYPO:0001939 ! abnormal ubiquinol-cytochrome-c reductase activity is_a: FYPO:0002118 ! decreased transporter activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0008121 ! ubiquinol-cytochrome-c reductase activity relationship: inheres_in GO:0008121 ! ubiquinol-cytochrome-c reductase activity created_by: midori creation_date: 2013-02-06T16:37:57Z [Term] id: FYPO:0001941 name: resistance to cerulenin def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of cerulenin than normal." [PomBase:mah] synonym: "resistance to cerulenin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to cerulenin during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to cerulenin" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:171741 ! cerulenin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:171741 ! cerulenin created_by: midori creation_date: 2013-02-06T16:51:46Z [Term] id: FYPO:0001942 name: increased duration of lag phase def: "A cell population phenotype in which a population in a culture remains in lag phase longer than normal. The onset of exponential growth is thus delayed." [PomBase:mah] synonym: "delayed exponential growth" EXACT [PomBase:al] synonym: "prolonged lag phase" EXACT [PomBase:al] is_a: FYPO:0000003 ! cell population phenotype is_a: FYPO:0001985 ! abnormal phenotype created_by: midori creation_date: 2013-02-06T16:55:57Z [Term] id: FYPO:0001943 name: abnormal microtubule binding def: "A molecular function phenotype in which occurrence of microtubule binding by a gene product (usually a protein) in a mutant is abnormal. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] comment: This term can be used for any interaction with microtubules that is affected by a mutation, whether or not the mutated gene product is one of the interacting proteins. We recommend noting which proteins were used in the assay when annotating to this term. is_a: FYPO:0003591 ! abnormal protein complex binding intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0008017 ! microtubule binding intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0008017 ! microtubule binding relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-02-06T17:06:58Z [Term] id: FYPO:0001944 name: abolished microtubule binding def: "A molecular function phenotype in which microtubule binding by a gene product (usually a protein) in a mutant does not occur. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] comment: This term can be used for any interaction with microtubules that is affected by a mutation, whether or not the mutated gene product is one of the interacting proteins. We recommend noting which proteins were used in the assay when annotating to this term. synonym: "microtubule binding abolished" EXACT [PomBase:mah] is_a: FYPO:0000705 ! abolished protein binding is_a: FYPO:0001943 ! abnormal microtubule binding intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0008017 ! microtubule binding relationship: towards GO:0008017 ! microtubule binding created_by: midori creation_date: 2013-02-06T17:07:06Z [Term] id: FYPO:0001945 name: normal protein secretion def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which protein secretion is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal protein secretion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein secretion during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001071 ! normal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0009306 ! protein secretion intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0009306 ! protein secretion relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-02-06T17:11:58Z [Term] id: FYPO:0001946 name: abolished mitotic sister chromatid separation def: "A cellular process phenotype in which mitotic sister chromatid separation does not occur." [PomBase:mah] synonym: "abolished mitotic chromosome separation" EXACT [PomBase:mah] synonym: "absent mitotic sister chromatid separation" EXACT [PomBase:mah] synonym: "mitotic sister chromatid separation abolished" EXACT [PomBase:mah] is_a: FYPO:0000670 ! abnormal mitotic sister chromatid separation is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0051306 ! mitotic sister chromatid separation relationship: towards GO:0051306 ! mitotic sister chromatid separation created_by: midori creation_date: 2013-02-07T11:58:07Z [Term] id: FYPO:0001947 name: abnormal cell cycle arrest in mitotic anaphase, with unseparated sister chromatids def: "A cellular process phenotype in which progression through the mitotic cell cycle is arrested in anaphase under conditions where arrest does not normally occur, and sister chromatids have not separated. The unseparated chromosomes remain condensed." [PomBase:mah] comment: This term was made obsolete because a cell with unseparated sister chromatids is by definition in metaphase. synonym: "abnormal cell cycle arrest in mitotic anaphase, with unseparated sister chromatids, during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal cell cycle arrest in mitotic anaphase, with unseparated, condensed chromosomes" EXACT [PomBase:mah, PomBase:vw] synonym: "abnormal cell cycle arrest in mitotic anaphase, with unseparated, condensed sister chromatids" EXACT [PomBase:mah, PomBase:vw] synonym: "abnormal mitotic cell cycle arrest in anaphase, with unseparated sister chromatids" EXACT [PomBase:mah] synonym: "absence of chromosome separation, abnormal mitotic anaphase arrest with condensed chromosomes" EXACT [PomBase:vw] is_obsolete: true consider: FYPO:0000392 created_by: midori creation_date: 2013-02-07T12:21:22Z [Term] id: FYPO:0001948 name: increased level of substance in cytosol def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of a specific substance measured in the cytosol is higher than normal." [PomBase:mah] synonym: "increased cytosolic level of substance" EXACT [PomBase:mah] synonym: "increased level of substance in cytosol during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased level of substance in cytosol during vegetative growth" EXACT [PomBase:mah] synonym: "reduced level of substance in cytosol" EXACT [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth is_a: FYPO:0001604 ! altered level of substance in cytosol intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005829 ! cytosol intersection_of: towards CHEBI:24431 ! chemical entity relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005829 ! cytosol relationship: towards CHEBI:24431 ! chemical entity created_by: midori creation_date: 2013-02-07T12:53:32Z [Term] id: FYPO:0001949 name: increased cytosolic calcium level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of calcium ion measured in the cytosol is higher than normal." [PomBase:mah] synonym: "increased cytosolic calcium ion level" EXACT [PomBase:mah] synonym: "increased cytosolic calcium ion level during vegetative growth" EXACT [PomBase:mah] synonym: "increased cytosolic calcium level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased level of calcium ions in cytosol" EXACT [PomBase:mah] synonym: "increased levels of free cytosolic calcium" EXACT [PomBase:vw] is_a: FYPO:0001198 ! increased cellular calcium level is_a: FYPO:0001948 ! increased level of substance in cytosol intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005829 ! cytosol intersection_of: towards CHEBI:29108 ! calcium(2+) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005829 ! cytosol relationship: towards CHEBI:29108 ! calcium(2+) created_by: midori creation_date: 2013-02-07T12:54:36Z [Term] id: FYPO:0001950 name: decreased sequestered calcium level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of calcium ion determined to be sequestered in a cell is lower than normal." [PMID:2145281, PomBase:mah] synonym: "decreased cellular sequestered calcium level" EXACT [PomBase:mah] synonym: "decreased levels of sequestered calcium" EXACT [PomBase:vw] synonym: "decreased sequestered calcium ion level" EXACT [PomBase:mah] synonym: "decreased sequestered calcium level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased sequestered calcium level during vegetative growth" EXACT [PomBase:mah] synonym: "reduced sequestered calcium level" EXACT [PomBase:mah] is_a: FYPO:0001197 ! decreased cellular calcium level created_by: midori creation_date: 2013-02-07T12:57:28Z [Term] id: FYPO:0001951 name: abnormal calcium export def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the export of calcium ions out of a cell is abnormal." [PomBase:mah] synonym: "abnormal calcium efflux from cell" EXACT [PomBase:vw] synonym: "abnormal calcium export during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal calcium export during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal calcium export from cell" NARROW [PomBase:mah] synonym: "abnormal calcium ion export" EXACT [PomBase:mah] synonym: "abnormal calcium ion export from cell" EXACT [PomBase:mah] synonym: "abnormal cellular calcium export" EXACT [PomBase:al] is_a: FYPO:0001336 ! transport phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0001720 ! abnormal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1990034 ! calcium ion export from cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1990034 ! calcium ion export from cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-02-07T13:03:00Z [Term] id: FYPO:0001952 name: decreased calcium export def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the export of calcium ions out of a cell occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased calcium efflux from cell" EXACT [PomBase:vw] synonym: "decreased calcium export during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased calcium export during vegetative growth" EXACT [PomBase:mah] synonym: "decreased calcium export from cell" NARROW [PomBase:mah] synonym: "decreased calcium ion export" EXACT [PomBase:mah] synonym: "decreased cellular calcium export" EXACT [PomBase:al] synonym: "reduced calcium export" EXACT [PomBase:mah] is_a: FYPO:0001951 ! abnormal calcium export is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990034 ! calcium ion export from cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990034 ! calcium ion export from cell created_by: midori creation_date: 2013-02-07T13:03:07Z [Term] id: FYPO:0001953 name: abnormal calcium import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of calcium ions into a cell is abnormal." [PomBase:mah] synonym: "abnormal calcium import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal calcium import during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal calcium import into cell" EXACT [PomBase:mah] synonym: "abnormal calcium ion import" EXACT [PomBase:mah] synonym: "abnormal cellular calcium import" EXACT [PomBase:al] is_a: FYPO:0001336 ! transport phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0001720 ! abnormal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1990035 ! calcium ion import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1990035 ! calcium ion import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-02-07T13:10:35Z [Term] id: FYPO:0001954 name: decreased calcium import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of calcium ions into a cell occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased calcium import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased calcium import during vegetative growth" EXACT [PomBase:mah] synonym: "decreased calcium import into cell" EXACT [PomBase:mah] synonym: "decreased calcium ion import" EXACT [PomBase:mah] synonym: "decreased calcium uptake" EXACT [PomBase:mah] synonym: "decreased calcium uptake into intracellular compartments" RELATED [PMID:2145281, PomBase:vw] synonym: "decreased cellular calcium import" EXACT [PomBase:al] synonym: "reduced calcium import" EXACT [PomBase:mah] is_a: FYPO:0001953 ! abnormal calcium import is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990035 ! calcium ion import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990035 ! calcium ion import into cell created_by: midori creation_date: 2013-02-07T13:12:30Z [Term] id: FYPO:0001955 name: spheroid cell def: "A cell morphology phenotype in which a cell is shaped in the form of a spheroid. In spheroid cells, there is much less difference between the long and short axes of the cell than in wild type. Spheroid cells may shorter than normal, with approximately the same diameter as normal, or they may be enlarged." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "cell morphology, round cells" RELATED [PomBase:mah] synonym: "cell morphology, rounded cells" RELATED [PomBase:mah] synonym: "rounded cell" EXACT [PomBase:vw] is_a: FYPO:0001126 ! abnormal cell shape is_a: PATO:0001865 ! spheroid intersection_of: PATO:0001865 ! spheroid intersection_of: inheres_in CL:0000000 ! cell relationship: inheres_in CL:0000000 ! cell created_by: midori creation_date: 2013-02-07T13:58:40Z [Term] id: FYPO:0001956 name: spherical cell def: "A cell morphology phenotype in which a cell is formed in the shape of a sphere." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "orb" EXACT [PomBase:jh, PomBase:vw] is_a: FYPO:0001955 ! spheroid cell is_a: PATO:0001499 ! spherical intersection_of: PATO:0001499 ! spherical intersection_of: inheres_in CL:0000000 ! cell relationship: inheres_in CL:0000000 ! cell created_by: midori creation_date: 2013-02-07T13:58:48Z [Term] id: FYPO:0001957 name: spheroid cell during nitrogen starvation def: "A cell morphology phenotype in which a cell is shaped in the form of a spheroid, when the cell is subject to nitrogen starvation. In spheroid cells, there is much less difference between the long and short axes of the cell than in wild type. Spheroid cells may shorter than normal, with approximately the same diameter as normal, or they may be enlarged." [PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "cell morphology, round cells during nitrogen starvation" RELATED [PomBase:mah] synonym: "cell morphology, rounded cells during nitrogen starvation" RELATED [PomBase:mah] synonym: "rounded cell during nitrogen starvation" EXACT [PomBase:mah] synonym: "spheroid cell during nitrogen depletion" EXACT [PomBase:vw] synonym: "spheroid cell during nitrogen deprivation" EXACT [PomBase:vw] is_a: FYPO:0000995 ! abnormal cell morphology during nitrogen starvation is_a: FYPO:0001955 ! spheroid cell intersection_of: PATO:0001865 ! spheroid intersection_of: exists_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in CL:0000000 ! cell relationship: exists_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in CL:0000000 ! cell created_by: midori creation_date: 2013-02-07T14:21:33Z [Term] id: FYPO:0001958 name: spherical cell during nitrogen starvation def: "A cell morphology phenotype in which a cell is formed in the shape of a sphere, when the cell is subject to nitrogen starvation." [PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "orb during nitrogen starvation" EXACT [PomBase:jh, PomBase:vw] synonym: "spherical cell during nitrogen depletion" EXACT [PomBase:vw] synonym: "spherical cell during nitrogen deprivation" EXACT [PomBase:vw] is_a: FYPO:0001956 ! spherical cell is_a: FYPO:0001957 ! spheroid cell during nitrogen starvation is_a: FYPO:0002196 ! abnormal vegetative cell shape intersection_of: PATO:0001499 ! spherical intersection_of: exists_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000000 ! cell relationship: exists_during GO:0006995 ! cellular response to nitrogen starvation relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000000 ! cell created_by: midori creation_date: 2013-02-07T14:22:08Z [Term] id: FYPO:0001959 name: normal cAMP level during nitrogen starvation def: "A cell phenotype in which the amount of cyclic AMP measured in a cell during nitrogen starvation is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "normal cAMP accumulation during nitrogen starvation" RELATED [PomBase:mah] synonym: "normal cAMP level during nitrogen depletion" EXACT [PomBase:vw] synonym: "normal cAMP level during nitrogen deprivation" EXACT [PomBase:vw] synonym: "normal cellular cAMP level during nitrogen starvation" EXACT [PomBase:mah] synonym: "normal cyclic AMP level during nitrogen starvation" EXACT [PomBase:mah] is_a: FYPO:0001666 ! normal cAMP level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in CL:0000000 ! cell intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:17489 ! 3',5'-cyclic AMP relationship: exists_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in CL:0000000 ! cell relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:17489 ! 3',5'-cyclic AMP created_by: midori creation_date: 2013-02-07T14:28:06Z [Term] id: FYPO:0001960 name: abnormal DNA topoisomerase II activity def: "A molecular function phenotype in which the observed rate of DNA topoisomerase II activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0061505 ! DNA topoisomerase II activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0061505 ! DNA topoisomerase II activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-02-07T14:33:51Z [Term] id: FYPO:0001961 name: decreased DNA topoisomerase II activity def: "A molecular function phenotype in which the observed rate of DNA topoisomerase II activity is decreased." [PomBase:mah] synonym: "reduced DNA topoisomerase II activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0001960 ! abnormal DNA topoisomerase II activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0061505 ! DNA topoisomerase II activity relationship: inheres_in GO:0061505 ! DNA topoisomerase II activity created_by: midori creation_date: 2013-02-07T14:34:15Z [Term] id: FYPO:0001962 name: abolished protein phosphatase activity def: "A molecular function phenotype in which a protein phosphatase activity is absent." [PomBase:mah] synonym: "protein phosphatase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0001756 ! abnormal protein phosphatase activity is_a: FYPO:0004303 ! abolished phosphatase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0004721 ! phosphoprotein phosphatase activity relationship: towards GO:0004721 ! phosphoprotein phosphatase activity created_by: midori creation_date: 2013-02-07T14:36:28Z [Term] id: FYPO:0001963 name: resistance to papulacandin B def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of papulacandin B than normal." [PomBase:mah] synonym: "resistance to papulacandin B during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to papulacandin B during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to papulacandin B" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:569624 ! papulacandin B relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:569624 ! papulacandin B created_by: midori creation_date: 2013-02-07T14:39:04Z [Term] id: FYPO:0001964 name: resistance to aculeacin A def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of aculeacin A than normal." [PomBase:mah] synonym: "resistance to aculeacin A during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to aculeacin A during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to aculeacin A" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:2450 ! aculeacin A relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:2450 ! aculeacin A created_by: midori creation_date: 2013-02-07T14:40:07Z [Term] id: FYPO:0001965 name: resistance to papulacandin D def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of papulacandin D than normal." [PomBase:mah] synonym: "resistance to papulacandin D during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to papulacandin D during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to papulacandin D" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:72630 ! papulacandin D relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:72630 ! papulacandin D created_by: midori creation_date: 2013-02-07T14:40:48Z [Term] id: FYPO:0001966 name: sensitive to aculeacin A def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to aculeacin A. Cells stop growing (and may die) at a concentration of aculeacin A that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to aculeacin A" EXACT [PomBase:mah] synonym: "sensitive to aculeacin A during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to aculeacin A during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:2450 ! aculeacin A relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:2450 ! aculeacin A created_by: midori creation_date: 2013-02-07T14:51:06Z [Term] id: FYPO:0001967 name: abnormal 1,3-beta-D-glucan synthase activity def: "A molecular function phenotype in which the observed rate of 1,3-beta-D-glucan synthase activity is abnormal." [PomBase:mah] is_a: FYPO:0001087 ! abnormal glucosyltransferase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0003843 ! 1,3-beta-D-glucan synthase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0003843 ! 1,3-beta-D-glucan synthase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-02-07T14:57:37Z [Term] id: FYPO:0001968 name: increased 1,3-beta-D-glucan synthase activity def: "A molecular function phenotype in which the observed rate of 1,3-beta-D-glucan synthase activity is increased." [PomBase:mah] is_a: FYPO:0001089 ! increased glucosyltransferase activity is_a: FYPO:0001967 ! abnormal 1,3-beta-D-glucan synthase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0003843 ! 1,3-beta-D-glucan synthase activity relationship: inheres_in GO:0003843 ! 1,3-beta-D-glucan synthase activity created_by: midori creation_date: 2013-02-07T14:57:45Z [Term] id: FYPO:0001969 name: increased 1,3-beta-D-glucan synthase activity during growth on papulacandin B def: "A molecular function phenotype in which the observed rate of 1,3-beta-D-glucan synthase activity is increased when cells are grown in medium containing papulacandin B." [PomBase:mah] is_a: FYPO:0001968 ! increased 1,3-beta-D-glucan synthase activity created_by: midori creation_date: 2013-02-07T14:57:51Z [Term] id: FYPO:0001970 name: increased 1,3-beta-D-glucan synthase activity during growth on aculeacin A def: "A molecular function phenotype in which the observed rate of 1,3-beta-D-glucan synthase activity is increased when cells are grown in medium containing aculeacin A." [PomBase:mah] is_a: FYPO:0001968 ! increased 1,3-beta-D-glucan synthase activity created_by: midori creation_date: 2013-02-07T15:01:22Z [Term] id: FYPO:0001971 name: abnormal cell separation after cytokinesis resulting in chained cells def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which cell separation after cytokinesis is abnormal, and results in the formation of a chain of cells. Cells in the chain visually resemble wild-type cells, except that they remain connected, often via remnants of septum edging material, and may continue to undergo normal mitosis and septum formation." [PMID:8873452, PomBase:mah, PomBase:vw] comment: This phenotype usually results from a defect late in septum degradation. synonym: "abnormal cell separation after cytokinesis resulting in chained cells during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal cell separation after cytokinesis resulting in chained cells during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal mitotic cytokinetic cell separation resulting in chained cells" EXACT [GO:0000920] synonym: "cell clumping" RELATED [PomBase:vw] synonym: "clumped cells" RELATED [PomBase:vw] is_a: FYPO:0000164 ! abnormal cell separation after cytokinesis created_by: midori creation_date: 2013-02-07T15:15:49Z [Term] id: FYPO:0001972 name: abnormal cell separation after cytokinesis resulting in septated cell def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which cell separation after cytokinesis is abnormal, and results in the formation of a septated cell. Nuclear division, contractile ring formation and constriction, and septum assembly are apparently normal, but the septum does not degrade. Additional rounds of nuclear division and cytokinesis may take place, resulting in the formation of a multiseptate cell." [PMID:12654901, PomBase:mah, PomBase:vw] comment: This phenotype usually results from a defect late in septum degradation. synonym: "abnormal cell separation after cytokinesis resulting in septated cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal cell separation after cytokinesis resulting in septated cell during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal mitotic cytokinetic cell separation resulting in septated cell" EXACT [GO:0000920] is_a: FYPO:0000164 ! abnormal cell separation after cytokinesis created_by: midori creation_date: 2013-02-07T15:23:02Z [Term] id: FYPO:0001973 name: abnormal cell separation after cytokinesis, with abnormal nuclear division def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which nuclear division, cytokinesis and subsequent cell separation are abnormal, resulting in the formation of a cell in which an undivided mass of DNA is located on one side of the septum. The septum does not degrade." [PMID:3283148, PomBase:mah, PomBase:vw] synonym: "abnormal cell separation after cytokinesis, with abnormal nuclear division during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal cell separation after cytokinesis, with abnormal nuclear division during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal mitotic cytokinetic cell separation, with abnormal nuclear division" EXACT [GO:0000920] is_a: FYPO:0000164 ! abnormal cell separation after cytokinesis created_by: midori creation_date: 2013-02-07T15:28:25Z [Term] id: FYPO:0001974 name: increased number of cells with 1C DNA content def: "A cell population phenotype in which greater than normal number of cells contain 1C DNA content. This may result from cell cycle arrest or delay." [PomBase:al] synonym: "increased amount of cells with 1C DNA content" EXACT [PomBase:al] synonym: "increased number of cells containing 1C DNA" EXACT [PomBase:al] is_a: FYPO:0000003 ! cell population phenotype is_a: FYPO:0001985 ! abnormal phenotype created_by: midori creation_date: 2013-02-07T16:00:02Z [Term] id: FYPO:0001975 name: normal growth on nocodazole def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing nocodazole." [PomBase:mah] synonym: "normal cell population growth in presence of nocodazole" EXACT [PomBase:mah] synonym: "normal cell population growth on nocodazole" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to nocodazole" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on nocodazole" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:34892 ! nocodazole relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:34892 ! nocodazole created_by: midori creation_date: 2013-02-07T16:04:27Z [Term] id: FYPO:0001976 name: normal cytoplasmic microtubules def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the morphology of cytoplasmic microtubules is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cytoplasmic microtubule morphology" EXACT [PomBase:al] synonym: "normal cytoplasmic microtubule structure" NARROW [PomBase:mah] synonym: "normal cytoplasmic microtubules during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cytoplasmic microtubules during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001313 ! normal subcellular component during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005881 ! cytoplasmic microtubule intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005881 ! cytoplasmic microtubule relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-02-07T16:06:45Z [Term] id: FYPO:0001977 name: increased cell wall galactomannan level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of galactomannan measured in the cell wall is greater than normal." [PomBase:mah] synonym: "increased cell wall galactomannan accumulation" RELATED [PomBase:mah] synonym: "increased cell wall galactomannan level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cell wall galactomannan level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001083 ! increased polysaccharide level is_a: FYPO:0002627 ! altered level of substance in cell wall intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0009277 ! fungal-type cell wall intersection_of: towards CHEBI:27680 ! galactomannan relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0009277 ! fungal-type cell wall relationship: towards CHEBI:27680 ! galactomannan created_by: midori creation_date: 2013-02-07T16:08:34Z [Term] id: FYPO:0001978 name: bent mitotic spindle def: "A spindle phenotype in which the mitotic spindle is not straight, but instead forms an angle where microtubules from opposite poles interdigitate." [PMID:1538784, PMID:2145514, PomBase:mah] synonym: "bent bipolar mitotic spindle" EXACT [PomBase:vw] synonym: "bent mitotic spindle during vegetative growth" EXACT [PomBase:mah] synonym: "V-shaped bipolar mitotic spindle" EXACT [PomBase:vw] is_a: FYPO:0001574 ! abnormal bipolar mitotic spindle is_a: FYPO:0003607 ! abnormal spindle morphology is_a: PATO:0000617 ! bent intersection_of: PATO:0000617 ! bent intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072686 ! mitotic spindle relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072686 ! mitotic spindle created_by: midori creation_date: 2013-02-08T17:13:24Z [Term] id: FYPO:0001979 name: increased lariat intron level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which excised introns in lariat form (i.e. not linearized) are present at greater levels than normal." [PomBase:al, PomBase:mah] synonym: "accumulation of lariat introns" RELATED [PomBase:mah] synonym: "increased lariat intron level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased lariat intron level during vegetative growth" EXACT [PomBase:mah] synonym: "increased level of lariat introns" EXACT [PomBase:vw] synonym: "lariat intron accumulation" RELATED [PomBase:vw] is_a: FYPO:0000825 ! increased RNA level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards SO:0001958 ! lariat_intron relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards SO:0001958 ! lariat_intron created_by: midori creation_date: 2013-02-13T14:38:24Z [Term] id: FYPO:0001980 name: normal RNA processing def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which RNA processing is normal (i.e. indistinguishable from wild type). RNA processing is the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GO:0006396, PomBase:mah] synonym: "normal RNA processing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal RNA processing during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000142 ! gene expression phenotype is_a: FYPO:0000859 ! normal metabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006396 ! RNA processing intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006396 ! RNA processing relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-02-13T14:50:30Z [Term] id: FYPO:0001981 name: decreased rate of DNA replication def: "A cellular process phenotype in which the rate, or speed, of DNA replication is decreased." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "reduced rate of DNA replication" EXACT [PomBase:mah] is_a: FYPO:0000217 ! abnormal DNA replication is_a: PATO:0000911 ! decreased rate intersection_of: PATO:0000911 ! decreased rate intersection_of: inheres_in GO:0006261 ! DNA-dependent DNA replication relationship: inheres_in GO:0006261 ! DNA-dependent DNA replication created_by: midori creation_date: 2013-02-13T14:54:35Z [Term] id: FYPO:0001982 name: decreased rate of DNA replication during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the rate, or speed, of DNA replication is decreased." [PomBase:mah] synonym: "decreased rate of DNA replication during mitotic cell cycle" RELATED [PomBase:mah] synonym: "reduced rate of DNA replication during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001343 ! abnormal mitotic DNA replication is_a: FYPO:0001981 ! decreased rate of DNA replication intersection_of: PATO:0000911 ! decreased rate intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902969 ! mitotic DNA replication relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902969 ! mitotic DNA replication created_by: midori creation_date: 2013-02-13T14:54:57Z [Term] id: FYPO:0001983 name: protein absent from cell def: "A cell phenotype in which the amount of protein measured in a cell is too low to detect. Total protein or a specific protein may be affected." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "undetectable cellular protein level" EXACT [PomBase:al] is_a: FYPO:0000835 ! decreased protein level is_a: FYPO:0001888 ! substance absent from cell intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:36080 ! protein relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2013-02-13T15:06:40Z [Term] id: FYPO:0001984 name: protein absent from cell during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell is too low to detect. Total protein or a specific protein may be affected." [PomBase:mah] synonym: "protein absent from cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "undetectable cellular protein level during vegetative growth" EXACT [PomBase:al] is_a: FYPO:0001208 ! substance absent from cell during vegetative growth is_a: FYPO:0001324 ! decreased protein level during vegetative growth is_a: FYPO:0001983 ! protein absent from cell intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:36080 ! protein relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2013-02-13T15:07:15Z [Term] id: FYPO:0001985 name: abnormal phenotype def: "A phenotype that shows detectable differences from normal. In fission yeast, the characteristics of wild type cells of the sequenced strain (972 h-) or the isogenic h+ or h90 strains are regarded as normal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast abnormal phenotype" EXACT [PomBase:mah] is_a: FYPO:0000001 ! phenotype is_a: PATO:0000001 ! quality intersection_of: PATO:0000001 ! quality intersection_of: inheres_in FYPO:0000001 ! phenotype intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in FYPO:0000001 ! phenotype relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-02-13T15:39:55Z [Term] id: FYPO:0001986 name: resistance to 5-fluorouracil def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of 5-fluorouracil than normal." [PomBase:mah] synonym: "resistance to 5-fluorouracil during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to 5-fluorouracil during vegetative growth" EXACT [PomBase:mah] synonym: "resistance to 5-FU" EXACT [PomBase:al] synonym: "resistant to 5-fluorouracil" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:46345 ! 5-fluorouracil relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:46345 ! 5-fluorouracil created_by: midori creation_date: 2013-02-13T16:51:16Z [Term] id: FYPO:0001987 name: sensitive to high pH def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to pH higher than that of standard S. pombe growth media (about 5.8). Cells stop growing (and may die) at a pH that allows wild type cells to grow." [PomBase:mah] comment: Also see 'sensitive to alkalinity' (FYPO:0000723). synonym: "hypersensitive to high pH" EXACT [PomBase:mah] synonym: "sensitive to high pH during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to high pH during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000304 ! sensitive to stress during vegetative growth created_by: midori creation_date: 2013-02-13T17:07:12Z [Term] id: FYPO:0001988 name: normal cell population growth at high pH def: "A cell population growth phenotype in which vegetative cells grow normally at a pH higher than that of standard S. pombe growth medium (abut 5.8)." [PomBase:mah] synonym: "normal growth at high pH" BROAD [PomBase:mah] synonym: "normal vegetative cell population growth at high pH" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth created_by: midori creation_date: 2013-02-13T17:11:42Z [Term] id: FYPO:0001989 name: sensitive to low pH def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to pH lower than that of standard S. pombe growth media (about 5.8). Cells stop growing (and may die) at a pH that allows wild type cells to grow." [PomBase:mah] comment: Also see 'sensitive to acidity' (FYPO:0000722). synonym: "hypersensitive to low pH" EXACT [PomBase:mah] synonym: "sensitive to low pH during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to low pH during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000304 ! sensitive to stress during vegetative growth created_by: midori creation_date: 2013-02-13T17:18:14Z [Term] id: FYPO:0001990 name: normal cell population growth at low pH def: "A cell population growth phenotype in which vegetative cells grow normally at a pH lower than that of standard S. pombe growth medium (abut 5.8)." [PomBase:mah] synonym: "normal growth at low pH" BROAD [PomBase:mah] synonym: "normal vegetative cell population growth at low pH" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth created_by: midori creation_date: 2013-02-13T17:20:01Z [Term] id: FYPO:0001991 name: inviable after spore germination, without cell division def: "A phenotype in which a spore germinates to produce a cell that dies without completing cell division." [PomBase:al, PomBase:mah] synonym: "essential; germinating spore, without cell division" RELATED [PomBase:mah] synonym: "inviable after spore germination, no cell division" EXACT [PomBase:al] synonym: "inviable following spore germination, without cell division" EXACT [PomBase:mah] synonym: "inviable germinated spore, without cell division" EXACT [PomBase:mah] is_a: FYPO:0000316 ! inviable after spore germination created_by: midori creation_date: 2013-02-13T17:25:34Z [Term] id: FYPO:0001992 name: inviable elongated mononucleate vegetative cell with mislocalized septum alt_id: FYPO:0001993 def: "A cell phenotype in which a cell contains a single septum, has one nucleus, is elongated, and is inviable. The septum is in an abnormal location, and the nucleus is located in one compartment of the septated cell." [PomBase:mah, PomBase:vw] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "inviable elongated mononucleate cell with abnormal septum location" EXACT [PomBase:mah] synonym: "inviable elongated mononucleate cell with abnormal septum position" EXACT [PomBase:mah] synonym: "inviable elongated mononucleate cell with asymmetric septum" EXACT [PomBase:mah] synonym: "inviable elongated mononucleate cell with asymmetrically located septum" EXACT [PomBase:mah] synonym: "inviable elongated mononucleate cell with mislocalised septum" EXACT [PomBase:mah] synonym: "inviable elongated mononucleate cell with mislocalized septum during vegetative growth" EXACT [PomBase:mah] synonym: "inviable elongated mononucleate monoseptate vegetative cell with mislocalized septum" EXACT [PomBase:mah] synonym: "inviable elongated mononucleate vegetative cell with mislocalized septum and mislocalized nucleus" EXACT [PomBase:mah] synonym: "inviable elongated mononucleate vegetative cell with mislocalized septum during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable elongated mononucleate vegetative cell with misplaced septum" EXACT [PomBase:vw] synonym: "inviable elongated mononucleate vegetative cell with single mislocalized septum" EXACT [PomBase:mah] synonym: "inviable long mononucleate cell with mislocalized septum" EXACT [PomBase:vw] synonym: "inviable vegetative elongated mononucleate cell with mislocalized septum" EXACT [PomBase:mah] is_a: FYPO:0001226 ! inviable mononucleate vegetative cell with mislocalized septum is_a: FYPO:0001917 ! elongated mononucleate monoseptate vegetative cell is_a: FYPO:0002889 ! inviable elongated vegetative cell with abnormal septum is_a: FYPO:0004255 ! inviable elongated mononucleate vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000060 ! mononucleate vegetative cell intersection_of: has_part FYPO:0000339 ! mislocalized septum during vegetative growth intersection_of: has_part FYPO:0001225 ! monoseptate intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000060 ! mononucleate vegetative cell relationship: has_part FYPO:0000339 ! mislocalized septum during vegetative growth relationship: has_part FYPO:0001225 ! monoseptate relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2013-02-20T16:55:53Z [Term] id: FYPO:0001994 name: inviable swollen elongated mononucleate vegetative cell with mislocalized septum near new end def: "A cell phenotype in which a cell contains a single septum, has one nucleus, is swollen, is elongated, and is inviable. In a swollen cell, both length and diameter are greater than normal, although the cell is only considered elongated if the length:width ratio is also greater than normal. The septum is in an abnormal location, and the nucleus is located in one compartment of the septated cell. The cell compartment containing the nucleus is swollen (i.e. has a larger diameter than the other compartment)." [PomBase:mah, PomBase:vw] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "inviable elongated mononucleate vegetative cell with mislocalized septum near new end and increased cell volume" EXACT [PomBase:mah] synonym: "inviable enlarged elongated mononucleate vegetative cell with mislocalized septum near new end" EXACT [PomBase:mah] synonym: "inviable swollen elongated mononucleate cell with mislocalized septum near non-growing end" NARROW [PomBase:mah] synonym: "inviable swollen elongated mononucleate monoseptate vegetative cell with mislocalized septum near new end" EXACT [PomBase:mah] synonym: "inviable swollen elongated mononucleate vegetative cell with mislocalised septum near new end" EXACT [PomBase:mah] synonym: "inviable swollen elongated mononucleate vegetative cell with mislocalized septum near new end and mislocalized nucleus" EXACT [PomBase:mah] synonym: "inviable swollen elongated mononucleate vegetative cell with mislocalized septum near new end during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable swollen elongated mononucleate vegetative cell with misplaced septum near new end" EXACT [PomBase:vw] synonym: "inviable swollen elongated mononucleate vegetative cell with single mislocalized septum near new end" EXACT [PomBase:mah] synonym: "long swollen mononucleate cell with mislocalized septum near new end" EXACT [PomBase:vw] synonym: "long swollen mononucleate cell with mislocalized septum near non-growing end" NARROW [PomBase:vw] synonym: "swollen elongated mononucleate cell with abnormal septum location near new end" EXACT [PomBase:mah] synonym: "swollen elongated mononucleate cell with abnormal septum location near non-growing end" NARROW [PomBase:mah] synonym: "swollen elongated mononucleate cell with abnormal septum position near new end" EXACT [PomBase:mah] synonym: "swollen elongated mononucleate cell with abnormal septum position near non-growing end" NARROW [PomBase:mah] synonym: "swollen elongated mononucleate cell with asymmetric septum near new end" EXACT [PomBase:mah] synonym: "swollen elongated mononucleate cell with asymmetric septum near non-growing end" NARROW [PomBase:mah] synonym: "swollen elongated mononucleate cell with asymmetrically located septum near new end" EXACT [PomBase:mah] synonym: "swollen elongated mononucleate cell with asymmetrically located septum near non-growing end" NARROW [PomBase:mah] synonym: "swollen elongated mononucleate cell with mislocalised septum near new end" EXACT [PomBase:mah] synonym: "swollen elongated mononucleate cell with mislocalised septum near non-growing end" NARROW [PomBase:mah] synonym: "swollen elongated mononucleate cell with mislocalized septum near new end" EXACT [PomBase:mah] synonym: "swollen elongated mononucleate cell with mislocalized septum near new end during vegetative growth" EXACT [PomBase:mah] synonym: "swollen elongated mononucleate cell with mislocalized septum near non-growing end" NARROW [PomBase:mah] synonym: "swollen elongated mononucleate cell with mislocalized septum near non-growing end during vegetative growth" NARROW [PomBase:mah] synonym: "swollen elongated mononucleate vegetative cell with mislocalized septum near non-growing end" NARROW [PomBase:mah] is_a: FYPO:0001992 ! inviable elongated mononucleate vegetative cell with mislocalized septum is_a: FYPO:0002103 ! inviable swollen mononucleate monoseptate vegetative cell is_a: FYPO:0002415 ! inviable swollen vegetative cell with abnormal cell shape is_a: FYPO:0002845 ! inviable swollen elongated septated cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000025 ! swollen cell intersection_of: has_part FYPO:0000060 ! mononucleate vegetative cell intersection_of: has_part FYPO:0001225 ! monoseptate intersection_of: has_part FYPO:0001391 ! mislocalized septum, near new end intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000025 ! swollen cell relationship: has_part FYPO:0000060 ! mononucleate vegetative cell relationship: has_part FYPO:0001225 ! monoseptate relationship: has_part FYPO:0001391 ! mislocalized septum, near new end relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: output_of FYPO:0002017 ! abnormal cell cycle arrest in mitotic interphase before NETO created_by: midori creation_date: 2013-02-20T17:01:11Z [Term] id: FYPO:0001995 name: normal growth on polymyxin B def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing polymyxin B." [PomBase:mah] synonym: "normal cell population growth in presence of polymyxin B" EXACT [PomBase:mah] synonym: "normal cell population growth on polymyxin B" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to polymyxin B" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on polymixin B" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:59063 ! polymyxin B2 relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:59063 ! polymyxin B2 created_by: midori creation_date: 2013-02-25T16:25:59Z [Term] id: FYPO:0001996 name: RNA absent from cell during nitrogen starvation def: "A cell phenotype in which the amount of RNA measured in a cell is too low to detect when the cell is subject to nitrogen starvation. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "RNA absent from cell during nitrogen depletion" EXACT [PomBase:vw] synonym: "RNA absent from cell during nitrogen deprivation" EXACT [PomBase:vw] synonym: "transcripts absent from cell during nitrogen starvation" EXACT [PomBase:vw] synonym: "undetectable cellular RNA level during nitrogen starvation" EXACT [PomBase:mah] is_a: FYPO:0001152 ! decreased RNA level during nitrogen starvation is_a: FYPO:0001889 ! RNA absent from cell intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2013-02-25T16:35:43Z [Term] id: FYPO:0001997 name: abnormal nucleoside diphosphate kinase activity def: "A molecular function phenotype in which the observed rate of nucleoside diphosphate kinase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004550 ! nucleoside diphosphate kinase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004550 ! nucleoside diphosphate kinase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-02-25T16:53:52Z [Term] id: FYPO:0001998 name: decreased nucleoside diphosphate kinase activity def: "A molecular function phenotype in which the observed rate of nucleoside diphosphate kinase activity is decreased." [PomBase:mah] synonym: "reduced nucleoside diphosphate kinase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0001997 ! abnormal nucleoside diphosphate kinase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004550 ! nucleoside diphosphate kinase activity relationship: inheres_in GO:0004550 ! nucleoside diphosphate kinase activity created_by: midori creation_date: 2013-02-25T16:53:59Z [Term] id: FYPO:0001999 name: increased nucleoside diphosphate kinase activity def: "A molecular function phenotype in which the observed rate of nucleoside diphosphate kinase activity is increased." [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0001997 ! abnormal nucleoside diphosphate kinase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0004550 ! nucleoside diphosphate kinase activity relationship: inheres_in GO:0004550 ! nucleoside diphosphate kinase activity created_by: midori creation_date: 2013-02-25T16:54:09Z [Term] id: FYPO:0002000 name: inviable septated mononucleate vegetative cell def: "A cell phenotype in which a cell contains one nucleus and one or more septa. This phenotype results from septation taking place without prior nuclear division. Cells with this phenotype are inviable, and the nucleus is not in the normal location." [PomBase:mah, PomBase:vw] synonym: "cytokinesis in the absence of nuclear division" RELATED [PomBase:al, PomBase:vw] synonym: "cytokinesis without nuclear division" RELATED [PomBase:al, PomBase:vw] synonym: "inviable cell with premature septation" RELATED [PomBase:al, PomBase:vw] synonym: "inviable septated mononucleate cell" EXACT [PomBase:vw] synonym: "inviable septated mononucleate cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable septated mononucleate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable septated mononucleate vegetative cell with mislocalized nucleus" EXACT [PomBase:mah] synonym: "septation in the absence of nuclear division" RELATED [PomBase:al, PomBase:vw] synonym: "septation independent of mitosis" RELATED [PomBase:al, PomBase:vw] synonym: "septation without nuclear division" RELATED [PomBase:al, PomBase:vw] is_a: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000060 ! mononucleate vegetative cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0002069 ! mislocalized nucleus intersection_of: has_part FYPO:0002342 ! septated vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000060 ! mononucleate vegetative cell relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0002069 ! mislocalized nucleus relationship: has_part FYPO:0002342 ! septated vegetative cell relationship: output_of FYPO:0001973 ! abnormal cell separation after cytokinesis, with abnormal nuclear division created_by: midori creation_date: 2013-02-27T13:08:58Z [Term] id: FYPO:0002001 name: mononucleate multiseptate vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell has one nucleus and more than one septum." [PomBase:mah] synonym: "cytokinesis in the absence of nuclear division" RELATED [PomBase:al, PomBase:vw] synonym: "cytokinesis without nuclear division" RELATED [PomBase:al, PomBase:vw] synonym: "mononucleate multiseptate cell during vegetative growth" EXACT [PomBase:mah] synonym: "mononucleate multiseptate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "septation in the absence of nuclear division" RELATED [PomBase:al, PomBase:vw] synonym: "septation independent of mitosis" RELATED [PomBase:al, PomBase:vw] synonym: "septation without nuclear division" RELATED [PomBase:al, PomBase:vw] synonym: "vegetative cell with premature septation" RELATED [PomBase:al, PomBase:vw] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000060 ! mononucleate vegetative cell intersection_of: has_part FYPO:0000118 ! multiseptate vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000060 ! mononucleate vegetative cell relationship: has_part FYPO:0000118 ! multiseptate vegetative cell created_by: midori creation_date: 2013-02-27T13:11:43Z [Term] id: FYPO:0002002 name: multiseptate vegetative cell, septa grouped def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell has one or more nuclei and more than one septum, and the septa are grouped together between two compartments, one or more of which may contain one or multiple nuclei." [PomBase:mah] synonym: "cytokinesis in the absence of nuclear division" RELATED [PomBase:al, PomBase:vw] synonym: "cytokinesis without nuclear division" RELATED [PomBase:al, PomBase:vw] synonym: "multiseptate cell, septa grouped, during vegetative growth" EXACT [PomBase:mah] synonym: "multiseptate vegetative cell, septa grouped during mitotic cell cycle" RELATED [PomBase:mah] synonym: "septation in the absence of nuclear division" RELATED [PomBase:al, PomBase:vw] synonym: "septation independent of mitosis" RELATED [PomBase:al, PomBase:vw] synonym: "septation without nuclear division" RELATED [PomBase:al, PomBase:vw] synonym: "vegetative cell with premature septation" RELATED [PomBase:al, PomBase:vw] is_a: FYPO:0000118 ! multiseptate vegetative cell created_by: midori creation_date: 2013-02-27T13:18:22Z [Term] id: FYPO:0002003 name: abolished RNA polymerase II core promoter proximal region sequence-specific DNA binding def: "A molecular function phenotype in which DNA binding at an RNA polymerase II core promoter proximal region by a gene product does not occur, when a gene or the bound DNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene. An RNA polymerase II core promoter proximal region is a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II." [GO:0000978, PomBase:mah] synonym: "abolished transcription factor binding to promoter region" RELATED [PomBase:al] synonym: "RNA polymerase II core promoter proximal region sequence-specific DNA binding abolished" EXACT [PomBase:mah] is_a: FYPO:0000659 ! abolished DNA binding intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0000978 ! RNA polymerase II core promoter proximal region sequence-specific DNA binding relationship: towards GO:0000978 ! RNA polymerase II core promoter proximal region sequence-specific DNA binding created_by: midori creation_date: 2013-02-27T13:45:01Z [Term] id: FYPO:0002004 name: microtubules absent from cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the cell does not contain detectable microtubules of one or more types." [PomBase:mah] synonym: "absent microtubules" EXACT [PomBase:mah] synonym: "microtubules absent from cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "microtubules absent from cell during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003684 ! altered level of macromolecular complex is_a: FYPO:0004315 ! abnormal microtubule cytoskeleton during vegetative growth is_a: PATO:0002000 ! lacks all parts of type intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards GO:0005874 ! microtubule relationship: inheres_in CL:0000000 ! cell relationship: towards GO:0005874 ! microtubule created_by: midori creation_date: 2013-02-27T13:50:36Z [Term] id: FYPO:0002005 name: lobate nuclear envelope def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the nuclear envelope has a lobate cross-section, i.e. one in which the edge has deep indentations or undulations that form lobes." [http://en.wikipedia.org/wiki/File\:Leaf_morphology.svg&oldid=313835870, PMID:2211869, PomBase:mah] comment: This term differs from 'nuclear envelope protrusion present' (FYPO:0003788) in that a lobate envelope has a few deep fissures extending inward from the cytoplasm that appear to partially divide the nucleus into portions, whereas protrusions are smaller and extend outward from the bulk of the nucleus. synonym: "leaf-like nuclear envelope morphology" RELATED [PomBase:al] synonym: "lobate nuclear envelope during mitotic cell cycle" RELATED [PomBase:mah] synonym: "lobate nuclear envelope during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000769 ! abnormal nuclear envelope morphology during vegetative growth is_a: PATO:0001367 ! lobate intersection_of: PATO:0001367 ! lobate intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005635 ! nuclear envelope relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005635 ! nuclear envelope created_by: midori creation_date: 2013-02-27T14:11:12Z [Term] id: FYPO:0002006 name: increased cellular iron level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of iron ions measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular iron ion level" EXACT [PomBase:mah] synonym: "increased cellular iron level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular iron level during vegetative growth" EXACT [PomBase:mah] synonym: "increased iron accumulation" RELATED [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:24875 ! iron cation relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:24875 ! iron cation created_by: midori creation_date: 2013-02-27T14:37:50Z [Term] id: FYPO:0002007 name: abnormal chromosome morphology, single irregular mass def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which chromosomes form a single, irregularly-shaped mass in the nucleus." [PMID:19074598, PomBase:mah] synonym: "abnormal chromatin organization with single irregular mass of chromatin" RELATED [PomBase:vw] is_a: FYPO:0000848 ! abnormal chromosome morphology created_by: midori creation_date: 2013-02-28T12:01:30Z [Term] id: FYPO:0002008 name: decreased aconitate hydratase activity def: "A molecular function phenotype in which the observed rate of aconitate hydratase (also known as aconitase) activity is decreased." [PomBase:mah] synonym: "decreased aconitase activity" EXACT [GO:0003994] synonym: "reduced aconitate hydratase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0000920 ! abnormal aconitate hydratase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0003994 ! aconitate hydratase activity relationship: inheres_in GO:0003994 ! aconitate hydratase activity created_by: midori creation_date: 2013-02-27T14:47:26Z [Term] id: FYPO:0002009 name: decreased oxygen consumption def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the amount of oxygen consumed by cells in a given time is lower than in wild type." [PomBase:mah] comment: Also see 'decreased cellular respiration' (FYPO:0000342). synonym: "decreased oxygen uptake" RELATED [PomBase:vw] synonym: "reduced oxygen consumption" EXACT [PomBase:mah] is_a: FYPO:0001348 ! cellular metabolism phenotype during vegetative growth created_by: midori creation_date: 2013-02-27T14:50:33Z [Term] id: FYPO:0002010 name: increased level of iron ion starvation-induced proteins def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein encoded by genes normally induced during iron ion starvation measured in a cell is higher than normal." [PomBase:mah] synonym: "increased level of iron ion depletion-induced proteins" EXACT [PomBase:vw] synonym: "increased level of iron ion deprivation-induced proteins" EXACT [PomBase:vw] synonym: "increased level of proteins expressed during iron ion starvation" EXACT [PomBase:mah] synonym: "increased level of proteins induced by iron ion starvation" EXACT [PomBase:mah] synonym: "increased protein level of genes (normally) induced during iron starvation" EXACT [PomBase:al] is_a: FYPO:0001327 ! increased protein level during vegetative growth created_by: midori creation_date: 2013-02-27T14:56:22Z [Term] id: FYPO:0002011 name: increased level of hydrogen peroxide-induced proteins during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein encoded by genes normally induced by exposure to hydrogen peroxide measured in a cell is higher than normal." [PomBase:mah] synonym: "increased level of H2O2-induced proteins during vegetative growth" EXACT [PomBase:mah] synonym: "increased level of hydrogen peroxide-induced proteins during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased level of proteins expressed during cellular response to hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] synonym: "increased level of proteins induced by hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] synonym: "increased protein level of genes (normally) induced during H2O2 stress during vegetative growth" EXACT [PomBase:al] is_a: FYPO:0001327 ! increased protein level during vegetative growth created_by: midori creation_date: 2013-02-27T14:59:57Z [Term] id: FYPO:0002012 name: decreased level of iron ion starvation-repressed proteins def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein encoded by genes normally repressed during iron ion starvation measured in a cell is higher than normal." [PomBase:mah] synonym: "decreased level of iron ion depletion-repressed proteins" EXACT [PomBase:vw] synonym: "decreased level of iron ion deprivation-repressed proteins" EXACT [PomBase:vw] synonym: "decreased level of proteins repressed by iron ion starvation" EXACT [PomBase:mah] synonym: "decreased level of proteins repressed during iron ion starvation" EXACT [PomBase:mah] synonym: "decreased protein level of genes (normally) repressed during iron starvation" EXACT [PomBase:al] synonym: "reduced level of iron ion starvation-repressed proteins" EXACT [PomBase:mah] is_a: FYPO:0001324 ! decreased protein level during vegetative growth created_by: midori creation_date: 2013-02-27T15:03:13Z [Term] id: FYPO:0002013 name: normal protein oxidation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which protein oxidation is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal protein oxidation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein oxidation during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein/peptide oxidation" EXACT [PomBase:mah] is_a: FYPO:0000549 ! normal protein modification during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0018158 ! protein oxidation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0018158 ! protein oxidation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-02-27T15:20:19Z [Term] id: FYPO:0002014 name: increased RNA level during cellular response to iron ion starvation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to iron ion starvation is higher than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased mRNA level during cellular response to iron ion starvation" NARROW [PomBase:mah] synonym: "increased RNA accumulation during cellular response to iron ion starvation" RELATED [PomBase:mah] synonym: "increased RNA level during cellular response to iron ion depletion" EXACT [PomBase:vw] synonym: "increased RNA level during cellular response to iron ion deprivation" EXACT [PomBase:vw] synonym: "increased RNA level during cellular response to iron ion starvation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased RNA level during cellular response to iron ion starvation during vegetative growth" EXACT [PomBase:mah] synonym: "increased RNA level during cellular response to iron starvation" EXACT [PomBase:mah] synonym: "increased RNA level during iron ion starvation" EXACT [PomBase:al] synonym: "increased transcript level during cellular response to iron ion starvation" EXACT [PomBase:vw] is_a: FYPO:0000825 ! increased RNA level during vegetative growth is_a: FYPO:0003196 ! altered RNA level during cellular response to iron ion starvation intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0010106 ! cellular response to iron ion starvation intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0010106 ! cellular response to iron ion starvation relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2013-02-27T15:22:02Z [Term] id: FYPO:0002015 name: sensitive to iron ion starvation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to iron ion starvation." [PomBase:mah] synonym: "hypersensitive to iron ion starvation" EXACT [PomBase:mah] synonym: "sensitive to iron ion depletion" EXACT [PomBase:vw] synonym: "sensitive to iron ion deprivation" EXACT [PomBase:vw] synonym: "sensitive to iron ion starvation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to iron ion starvation during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to iron starvation" EXACT [PomBase:mah] is_a: FYPO:0000304 ! sensitive to stress during vegetative growth created_by: midori creation_date: 2013-02-27T15:24:45Z [Term] id: FYPO:0002016 name: sensitive to oxygen def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to oxygen. Cells stop growing (and may die) at a level of oxygen that allows wild type cells to grow." [PomBase:mah] comment: Also consider the term 'sensitive to oxidative stress' (FYPO:0000726). synonym: "hypersensitive to oxygen" EXACT [PomBase:mah] synonym: "sensitive to elemental oxygen" EXACT [CHEBI:33262, PomBase:mah] synonym: "sensitive to oxygen during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to oxygen during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:33262 ! elemental oxygen relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:33262 ! elemental oxygen created_by: midori creation_date: 2013-02-27T15:36:25Z [Term] id: FYPO:0002017 name: abnormal cell cycle arrest in mitotic interphase before NETO def: "A cellular process phenotype in which the mitotic cell cycle is arrested during G2 phase, before new end take-off (NETO) has occurred, under conditions where arrest does not normally occur." [PomBase:mah] synonym: "abnormal cell cycle arrest in mitotic interphase before activation of bipolar cell growth" EXACT [GO:0051519] synonym: "abnormal cell cycle arrest in mitotic interphase before NETO during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal cell cycle arrest in mitotic interphase before new end take-off" RELATED [GO:0051519] synonym: "abnormal mitotic cell cycle arrest in interphase before NETO" EXACT [PomBase:mah] synonym: "cell cycle arrest in mitotic interphase before NETO" BROAD [PomBase:vw] is_a: FYPO:0003373 ! abnormal cell cycle arrest in mitotic G2 phase intersection_of: PATO:0001561 ! having extra processual parts intersection_of: during GO:0000085 ! mitotic G2 phase intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: precedes GO:0051519 ! activation of bipolar cell growth intersection_of: towards GO:0071850 ! mitotic cell cycle arrest relationship: during GO:0000085 ! mitotic G2 phase relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_output FYPO:0001018 ! abolished activation of bipolar cell growth relationship: precedes GO:0051519 ! activation of bipolar cell growth relationship: towards GO:0071850 ! mitotic cell cycle arrest created_by: midori creation_date: 2013-02-27T15:46:41Z [Term] id: FYPO:0002018 name: mitotic spindle absent from cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the cell does not contain a detectable mitotic spindle." [PomBase:mah] synonym: "absent mitotic spindle" EXACT [PomBase:mah] synonym: "mitotic spindle absent from cell during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000338 ! abnormal mitotic spindle is_a: PATO:0002000 ! lacks all parts of type intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards GO:0072686 ! mitotic spindle relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards GO:0072686 ! mitotic spindle created_by: midori creation_date: 2013-02-27T15:54:06Z [Term] id: FYPO:0002019 name: elongated telomeres def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells form telomeres that are longer than normal." [PomBase:mah] synonym: "elongated telomeres during mitotic cell cycle" RELATED [PomBase:mah] synonym: "elongated telomeres during vegetative growth" EXACT [PomBase:mah] synonym: "increased telomere length" EXACT [PomBase:mah] synonym: "long telomeres" EXACT [PomBase:mah] is_a: FYPO:0002254 ! abnormal telomere morphology is_a: PATO:0000573 ! increased length intersection_of: PATO:0000573 ! increased length intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000781 ! chromosome, telomeric region relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000781 ! chromosome, telomeric region created_by: midori creation_date: 2013-02-28T13:34:43Z [Term] id: FYPO:0002020 name: increased RNA level during nitrogen starvation def: "A cell phenotype in which the amount of RNA measured in a cell when the cell is subject to nitrogen starvation is higher than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased RNA accumulation during nitrogen starvation" RELATED [PomBase:mah] synonym: "increased RNA level during nitrogen depletion" EXACT [PomBase:vw] synonym: "increased RNA level during nitrogen deprivation" EXACT [PomBase:vw] synonym: "increased transcript level during nitrogen starvation" EXACT [PomBase:vw] is_a: FYPO:0001890 ! increased RNA level is_a: FYPO:0004139 ! altered level of substance in cell during nitrogen starvation intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2013-02-28T13:42:00Z [Term] id: FYPO:0002021 name: dispersed actin cortical patch localization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which actin cortical patches are localized throughout the cell cortex (rather than concentrated at the cell ends as in wild type cells)." [PMID:8834798, PomBase:mah] synonym: "delocalised actin cortical patches" EXACT [PomBase:vw] synonym: "delocalized actin cortical patches" EXACT [PomBase:vw] synonym: "dispersed actin cortical patch localisation" EXACT [PomBase:mah] synonym: "dispersed actin cortical patch location" RELATED [PomBase:mah] is_a: FYPO:0001321 ! cellular physical quality phenotype during vegetative growth is_a: FYPO:0003988 ! mislocalized actin cortical patches is_a: PATO:0001630 ! dispersed intersection_of: PATO:0001630 ! dispersed intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0030479 ! actin cortical patch relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0030479 ! actin cortical patch created_by: midori creation_date: 2013-02-28T13:54:07Z [Term] id: FYPO:0002022 name: normal actin cortical patch morphology def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, and structure of actin cortical patches are normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal actin cortical patch morphology during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal actin cortical patch morphology during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001313 ! normal subcellular component during vegetative growth is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0030479 ! actin cortical patch intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0030479 ! actin cortical patch relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-02-28T13:57:25Z [Term] id: FYPO:0002023 name: abnormal septum morphology during vegetative growth def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of the septum is abnormal." [PomBase:mah] comment: Note that an abnormal septum organization process may, but does not necessarily, result in abnormal septum morphology. synonym: "abnormal septum morphology during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0002455 ! abnormal septum during vegetative growth is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000935 ! barrier septum intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000935 ! barrier septum relationship: output_of FYPO:0000117 ! abnormal septation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-02-28T14:08:39Z [Term] id: FYPO:0002024 name: inviable elongated multinucleate aseptate vegetative cell def: "A cell morphology phenotype in which a vegetative cell is inviable, longer than normal, has no septum, and contains more than one nucleus." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "elongated multinucleate aseptate inviable vegetative cell" EXACT [PomBase:mah] synonym: "essential; elongated multinucleate inviable vegetative cell" RELATED [PomBase:mah] synonym: "inviable elongated multinucleate aseptate cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable elongated multinucleate aseptate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001493 ! inviable elongated multinucleate vegetative cell is_a: FYPO:0002049 ! elongated multinucleate aseptate vegetative cell is_a: FYPO:0002066 ! inviable elongated aseptate cell is_a: FYPO:0004106 ! inviable multinucleate aseptate vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000061 ! multinucleate vegetative cell intersection_of: has_part FYPO:0000949 ! aseptate intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000061 ! multinucleate vegetative cell relationship: has_part FYPO:0000949 ! aseptate relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2013-02-28T14:14:17Z [Term] id: FYPO:0002025 name: inviable elongated multinucleate vegetative cell with abnormal septum morphology def: "A cell morphology phenotype in which a vegetative cell is inviable, longer than normal, contains a septum with abnormal morphology (i.e. size, shape, or structure), and contain more than one nucleus." [PMID:8834798, PomBase:mah] comment: In cells with this phenotype, an abnormal septum forms on the surface from one side of the cell and then extends in a disorganized manner into the interior. Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "elongated multinucleate aseptate inviable vegetative cell with abnormal septum morphology" EXACT [PomBase:mah] synonym: "essential; elongated multinucleate inviable vegetative cell with abnormal septum morphology" RELATED [PomBase:mah] synonym: "inviable elongated multinucleate cell with abnormal septum morphology during vegetative growth" EXACT [PomBase:mah] synonym: "inviable elongated multinucleate vegetative cell with abnormal septum morphology during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001493 ! inviable elongated multinucleate vegetative cell is_a: FYPO:0002889 ! inviable elongated vegetative cell with abnormal septum intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000061 ! multinucleate vegetative cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0002023 ! abnormal septum morphology during vegetative growth relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000061 ! multinucleate vegetative cell relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0002023 ! abnormal septum morphology during vegetative growth created_by: midori creation_date: 2013-02-28T14:18:31Z [Term] id: FYPO:0002026 name: actomyosin contractile ring displaced from midpoint def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell forms an actomyosin contractile ring that is perpendicular to the long axis of the cell, but is not located at the midpoint of the long axis." [PMID:8834798, PomBase:mah] synonym: "actomyosin contractile ring displaced from cell center" EXACT [PomBase:mah] synonym: "actomyosin contractile ring displaced from cell centre" EXACT [PomBase:mah] synonym: "actomyosin contractile ring displaced from midpoint" EXACT [PomBase:vw] synonym: "cytokinetic contractile ring displaced from midpoint" EXACT [PomBase:vw] is_a: FYPO:0001369 ! mislocalized actomyosin contractile ring created_by: midori creation_date: 2013-02-28T15:34:27Z [Term] id: FYPO:0002027 name: angled actomyosin contractile ring def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell forms an actomyosin contractile ring that is not perpendicular to the long axis of the cell." [PMID:8834798, PomBase:mah] comment: Note that a cell that has this phenotype will usually also subsequently display the phenotype 'binucleate monoseptate cell, with angled septum' (FYPO:0002156). synonym: "actomyosin contractile ring not orthogonal to long axis of cell" EXACT [PomBase:mah] synonym: "actomyosin contractile ring not perpendicular to long axis of cell" RELATED [PomBase:mah] synonym: "angled cytokinetic contractile ring" EXACT [PomBase:vw] synonym: "angled mitotic contractile ring" EXACT [PomBase:vw] synonym: "tilted actomyosin contractile ring" EXACT [PMID:8834798] is_a: FYPO:0001369 ! mislocalized actomyosin contractile ring created_by: midori creation_date: 2013-02-28T15:43:06Z [Term] id: FYPO:0002028 name: multiple actomyosin contractile rings present def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which a cell contains more than one actomyosin contractile ring." [PMID:8834798, PomBase:mah] synonym: "actomyosin contractile rings present in greater numbers" EXACT [PomBase:mah] synonym: "multiple cytokinetic contractile rings present" EXACT [PomBase:vw] synonym: "multiple mitotic contractile rings present" EXACT [PomBase:vw] is_a: FYPO:0002398 ! abnormal actin cytoskeleton during vegetative growth is_a: PATO:0002002 ! has extra parts of type intersection_of: PATO:0002002 ! has extra parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0005826 ! actomyosin contractile ring relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0005826 ! actomyosin contractile ring created_by: midori creation_date: 2013-02-28T15:45:46Z [Term] id: FYPO:0002029 name: abnormal cell division, large and small daughter cells def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which a cell divides asymmetrically, resulting in the formation of daughter cells that are not the same size." [PMID:8834798, PomBase:mah] is_a: FYPO:0000186 ! abnormal cell division relationship: output_of FYPO:0000033 ! abnormal actomyosin contractile ring localization created_by: midori creation_date: 2013-02-28T15:54:13Z [Term] id: FYPO:0002030 name: abnormal actin cable organization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which actin cable organization is abnormal. The process normally results in the assembly, arrangement of constituent parts, or disassembly of an actin cable. Actin cables are the form of actin filament bundles found in yeasts." [GO:0032432, PomBase:mah] synonym: "abnormal actin cable organisation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal actin cable organization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal actin cable organization during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal actin filament bundle organization during vegetative growth" EXACT [GO:0032432] is_a: FYPO:0000727 ! abnormal actin filament organization during vegetative growth is_a: FYPO:0001354 ! abnormal cellular component assembly during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0061572 ! actin filament bundle organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0061572 ! actin filament bundle organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-02-28T16:07:31Z [Term] id: FYPO:0002031 name: abnormal actin cable morphology def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of actin cables is abnormal. Actin cables are the form of actin filament bundles found in yeasts." [PomBase:mah] synonym: "abnormal actin cable morphology during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal actin cable morphology during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal actin filament bundle morphology" EXACT [GO:0032432] synonym: "disorganized actin cables" EXACT [PomBase:vw] is_a: FYPO:0000350 ! abnormal actin cytoskeleton morphology during vegetative growth is_a: FYPO:0002435 ! abnormal actin cables intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0032432 ! actin filament bundle intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0032432 ! actin filament bundle relationship: output_of FYPO:0002030 ! abnormal actin cable organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-02-28T16:07:51Z [Term] id: FYPO:0002032 name: abnormal actin cable morphology during mitosis def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of actin cables is abnormal during mitosis. Actin cables are the form of actin filament bundles found in yeasts." [PomBase:mah] synonym: "abnormal actin cable morphology during mitosis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal actin cable morphology during mitosis during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal actin cable morphology during mitotic M phase" EXACT [PomBase:mah] synonym: "abnormal actin cable morphology during mitotic nuclear division" EXACT [GO:0007067] synonym: "abnormal actin filament bundle morphology during mitosis" EXACT [GO:0032432] synonym: "disorganized actin cables during mitosis" EXACT [PomBase:vw] is_a: FYPO:0002031 ! abnormal actin cable morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0007067 ! mitotic nuclear division intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0032432 ! actin filament bundle intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0007067 ! mitotic nuclear division relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0032432 ! actin filament bundle relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-02-28T16:27:15Z [Term] id: FYPO:0002033 name: abolished protein phosphorylation during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, does not occur." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein phosphorylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein phosphorylation abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000544 ! abolished protein modification during vegetative growth is_a: FYPO:0000775 ! abnormal protein phosphorylation during vegetative growth is_a: FYPO:0002678 ! abolished protein phosphorylation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0006468 ! protein phosphorylation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2013-02-28T16:31:47Z [Term] id: FYPO:0002034 name: abnormal DNA topoisomerase type I activity def: "A molecular function phenotype in which the observed rate of DNA topoisomerase type I activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0003917 ! DNA topoisomerase type I activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0003917 ! DNA topoisomerase type I activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-02-28T16:34:22Z [Term] id: FYPO:0002035 name: decreased DNA topoisomerase type I activity def: "A molecular function phenotype in which the observed rate of DNA topoisomerase type I activity is decreased." [PomBase:mah] synonym: "reduced DNA topoisomerase type I activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0002034 ! abnormal DNA topoisomerase type I activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0003917 ! DNA topoisomerase type I activity relationship: inheres_in GO:0003917 ! DNA topoisomerase type I activity created_by: midori creation_date: 2013-02-28T16:34:29Z [Term] id: FYPO:0002036 name: abnormal endodeoxyribonuclease activity def: "A molecular function phenotype in which the observed rate of an endodeoxyribonuclease activity is abnormal." [PomBase:mah] is_a: FYPO:0003163 ! abnormal nuclease activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004520 ! endodeoxyribonuclease activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004520 ! endodeoxyribonuclease activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-02-28T16:37:28Z [Term] id: FYPO:0002037 name: decreased endodeoxyribonuclease activity def: "A molecular function phenotype in which the observed rate of an endodeoxyribonuclease activity is decreased." [PomBase:mah] synonym: "reduced endodeoxyribonuclease activity" EXACT [PomBase:mah] is_a: FYPO:0002036 ! abnormal endodeoxyribonuclease activity is_a: FYPO:0004253 ! decreased nuclease activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004520 ! endodeoxyribonuclease activity relationship: inheres_in GO:0004520 ! endodeoxyribonuclease activity created_by: midori creation_date: 2013-02-28T16:37:38Z [Term] id: FYPO:0002038 name: abnormal deadenylation-independent decapping of nuclear-transcribed mRNA def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which deadenylation-independent decapping of nuclear-transcribed mRNA is abnormal. This decapping process is cleavage of the 5'-cap of a nuclear-transcribed mRNA, independent of poly(A) tail shortening. All RNA decapping may be abnormal, or one or more specific RNA molecules may be selectively affected." [GO:0031087, PomBase:mah] synonym: "abnormal deadenylation-independent decapping of nuclear-transcribed mRNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal deadenylation-independent decapping of nuclear-transcribed mRNA during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000294 ! RNA metabolism phenotype is_a: FYPO:0001363 ! abnormal metabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0031087 ! deadenylation-independent decapping of nuclear-transcribed mRNA intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0031087 ! deadenylation-independent decapping of nuclear-transcribed mRNA relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-03-08T11:32:33Z [Term] id: FYPO:0002039 name: decreased deadenylation-independent decapping of nuclear-transcribed mRNA def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of deadenylation-independent decapping of nuclear-transcribed mRNA is decreased. All RNA decapping may be decreased, or one or more specific RNA molecules may be selectively affected." [PomBase:mah] synonym: "decreased deadenylation-independent decapping of nuclear-transcribed mRNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased deadenylation-independent decapping of nuclear-transcribed mRNA during vegetative growth" EXACT [PomBase:mah] synonym: "reduced deadenylation-independent decapping of nuclear-transcribed mRNA" EXACT [PomBase:mah] is_a: FYPO:0002038 ! abnormal deadenylation-independent decapping of nuclear-transcribed mRNA is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0031087 ! deadenylation-independent decapping of nuclear-transcribed mRNA relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0031087 ! deadenylation-independent decapping of nuclear-transcribed mRNA created_by: midori creation_date: 2013-03-08T11:33:11Z [Term] id: FYPO:0002040 name: increased deadenylation-independent decapping of nuclear-transcribed mRNA def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of deadenylation-independent decapping of nuclear-transcribed mRNA is increased. All RNA decapping may be increased, or one or more specific RNA molecules may be selectively affected." [PomBase:mah] synonym: "increased deadenylation-independent decapping of nuclear-transcribed mRNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased deadenylation-independent decapping of nuclear-transcribed mRNA during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002038 ! abnormal deadenylation-independent decapping of nuclear-transcribed mRNA is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0031087 ! deadenylation-independent decapping of nuclear-transcribed mRNA relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0031087 ! deadenylation-independent decapping of nuclear-transcribed mRNA created_by: midori creation_date: 2013-03-08T11:33:36Z [Term] id: FYPO:0002041 name: abolished deadenylation-independent decapping of nuclear-transcribed mRNA def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which deadenylation-independent decapping of nuclear-transcribed mRNA does not occur. All RNA decapping may be abolished, or one or more specific RNA molecules may be selectively affected." [PomBase:mah] synonym: "abolished deadenylation-independent decapping of nuclear-transcribed mRNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "absent deadenylation-independent decapping of nuclear-transcribed mRNA" EXACT [PomBase:mah] synonym: "deadenylation-independent decapping of nuclear-transcribed mRNA abolished" EXACT [PomBase:mah] synonym: "deadenylation-independent decapping of nuclear-transcribed mRNA abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002038 ! abnormal deadenylation-independent decapping of nuclear-transcribed mRNA is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0031087 ! deadenylation-independent decapping of nuclear-transcribed mRNA relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0031087 ! deadenylation-independent decapping of nuclear-transcribed mRNA created_by: midori creation_date: 2013-03-08T11:33:48Z [Term] id: FYPO:0002042 name: decreased RNA level during cellular response to iron ion starvation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to iron ion starvation is lower than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased mRNA level during cellular response to iron ion starvation" NARROW [PomBase:mah] synonym: "decreased RNA accumulation during cellular response to iron ion starvation" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to iron ion depletion" EXACT [PomBase:vw] synonym: "decreased RNA level during cellular response to iron ion deprivation" EXACT [PomBase:vw] synonym: "decreased RNA level during cellular response to iron ion starvation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to iron ion starvation during vegetative growth" EXACT [PomBase:mah] synonym: "decreased RNA level during cellular response to iron starvation" EXACT [GO:0036225, PomBase:mah] synonym: "decreased RNA level during iron ion starvation" EXACT [PomBase:al] synonym: "decreased transcript level during cellular response to iron ion starvation" EXACT [PomBase:vw] synonym: "reduced RNA level during cellular response to iron ion starvation" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth is_a: FYPO:0003196 ! altered RNA level during cellular response to iron ion starvation intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0010106 ! cellular response to iron ion starvation intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0010106 ! cellular response to iron ion starvation relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2013-03-14T15:30:48Z [Term] id: FYPO:0002043 name: normal premeiotic DNA replication def: "A cellular process phenotype in which premeiotic DNA replication is normal." [PomBase:mah] synonym: "abnormal premeiotic DNA synthesis" RELATED [GO:0006279, GOC:mah] synonym: "normal meiotic DNA replication" RELATED [GO:0006279, GOC:mah] synonym: "normal meiotic DNA synthesis" RELATED [GO:0006279, GOC:mah] is_a: FYPO:0001133 ! normal DNA replication intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0006279 ! premeiotic DNA replication intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0006279 ! premeiotic DNA replication relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-03-14T15:45:15Z [Term] id: FYPO:0002044 name: abolished premeiotic DNA replication def: "A cellular process phenotype in which premeiotic DNA replication does not occur." [PomBase:mah] synonym: "absent premeiotic DNA replication" EXACT [PomBase:mah] synonym: "premeiotic DNA replication abolished" EXACT [PomBase:mah] is_a: FYPO:0000625 ! abnormal premeiotic DNA replication is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0006279 ! premeiotic DNA replication relationship: towards GO:0006279 ! premeiotic DNA replication created_by: midori creation_date: 2013-03-14T15:48:07Z [Term] id: FYPO:0002045 name: resistance to heat shock def: "A cell phenotype in which cells show decreased sensitivity to heat shock. Heat shock is a form of heat stress in which cells are briefly exposed to a very high temperature." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "resistant to heat shock" EXACT [PomBase:mah] is_a: FYPO:0002046 ! resistance to stress created_by: midori creation_date: 2013-03-14T15:54:13Z [Term] id: FYPO:0002046 name: resistance to stress def: "A phenotype in which cells in a population show decreased sensitivity to a stress. Typically, a cell population are deemed resistant to a stress if cells in the population grow and divide when exposed to the stress at an intensity at which wild-type cells stop growing (and may die)." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. Use a descendant of this term if you have assayed growth of cells exposed to a stress in culture. If you have assayed the response to the stress at the subcellular or molecular level, consider annotating to a descendant of 'abnormal cellular response to stress' (FYPO:0000162). subset: qc_do_not_manually_annotate synonym: "resistant to stress" EXACT [PomBase:mah] synonym: "stress resistance: increased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000139 ! cell population growth phenotype created_by: midori creation_date: 2013-03-14T15:56:42Z [Term] id: FYPO:0002047 name: resistance to heat shock during nitrogen starvation def: "A cell phenotype in which cells show decreased sensitivity to heat shock, when the cell is also subject to nitrogen starvation. Heat shock is a form of heat stress in which cells are briefly exposed to a very high temperature." [PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "resistance to heat shock during nitrogen depletion" EXACT [PomBase:vw] synonym: "resistance to heat shock during nitrogen deprivation" EXACT [PomBase:vw] synonym: "resistant to heat shock during nitrogen starvation" EXACT [PomBase:mah] is_a: FYPO:0002045 ! resistance to heat shock created_by: midori creation_date: 2013-03-14T16:00:03Z [Term] id: FYPO:0002048 name: normal cell morphology during nitrogen starvation def: "A cell phenotype characterized by normal cell morphology (i.e. size, shape, and structure) when the cell is subject to nitrogen starvation." [PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "normal cell morphology during nitrogen depletion" EXACT [PomBase:vw] synonym: "normal cell morphology during nitrogen deprivation" EXACT [PomBase:vw] is_a: FYPO:0000672 ! normal cell morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in CL:0000000 ! cell intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in CL:0000000 ! cell relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-03-14T16:29:43Z [Term] id: FYPO:0002049 name: elongated multinucleate aseptate vegetative cell def: "A cell morphology phenotype in which vegetative a cell is longer than normal, has no septum, and contains more than one nucleus." [PomBase:mah] synonym: "elongated multinucleate aseptate cells during vegetative growth" EXACT [PomBase:mah] synonym: "elongated multinucleate aseptate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000133 ! elongated multinucleate vegetative cell is_a: FYPO:0000950 ! elongated aseptate cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000061 ! multinucleate vegetative cell intersection_of: has_part FYPO:0000949 ! aseptate relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000061 ! multinucleate vegetative cell relationship: has_part FYPO:0000949 ! aseptate created_by: midori creation_date: 2013-03-14T16:36:18Z [Term] id: FYPO:0002050 name: branched elongated multinucleate aseptate vegetative cell def: "A cell morphology phenotype in which vegetative a cell is branched, longer than normal, has no septum, and contains more than one nucleus." [PomBase:mah] synonym: "branched elongated multinucleate aseptate cell during vegetative growth" EXACT [PomBase:mah] synonym: "branched elongated multinucleate aseptate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001512 ! branched, elongated cell is_a: FYPO:0002049 ! elongated multinucleate aseptate vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000015 ! branched vegetative cell intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000061 ! multinucleate vegetative cell intersection_of: has_part FYPO:0000949 ! aseptate relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000015 ! branched vegetative cell relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000061 ! multinucleate vegetative cell relationship: has_part FYPO:0000949 ! aseptate created_by: midori creation_date: 2013-03-14T16:40:20Z [Term] id: FYPO:0002051 name: swollen elongated multinucleate aseptate vegetative cell def: "A cell morphology phenotype in which a vegetative cell is swollen, longer than normal, has no septum, and contains more than one nucleus. In a swollen cell, both length and diameter are greater than normal, although the cell is only considered elongated if the length:width ratio is also greater than normal." [PomBase:mah] synonym: "elongated multinucleate aseptate vegetative cell with increased cell volume" EXACT [PomBase:mah] synonym: "enlarged elongated multinucleate aseptate vegetative cell" RELATED [PomBase:mah] synonym: "large elongated multinucleate aseptate vegetative cell" RELATED [PomBase:mah] synonym: "swollen elongated multinucleate aseptate cell during vegetative growth" EXACT [PomBase:mah] synonym: "swollen elongated multinucleate aseptate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001429 ! swollen elongated cell is_a: FYPO:0002049 ! elongated multinucleate aseptate vegetative cell is_a: FYPO:0004257 ! swollen multinucleate vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000025 ! swollen cell intersection_of: has_part FYPO:0000061 ! multinucleate vegetative cell intersection_of: has_part FYPO:0000949 ! aseptate relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000025 ! swollen cell relationship: has_part FYPO:0000061 ! multinucleate vegetative cell relationship: has_part FYPO:0000949 ! aseptate created_by: midori creation_date: 2013-03-14T16:41:21Z [Term] id: FYPO:0002052 name: normal sporulation frequency def: "A cellular process phenotype in which the occurrence of ascospore formation is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal ascospore formation frequency" EXACT [PomBase:mah] synonym: "normal sporulation occurrence" EXACT [PomBase:mah] is_a: FYPO:0000590 ! normal sporulation is_a: PATO:0000057 ! occurrence intersection_of: PATO:0000057 ! occurrence intersection_of: inheres_in GO:0030437 ! ascospore formation intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0030437 ! ascospore formation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-03-15T16:28:36Z [Term] id: FYPO:0002053 name: normal DNA topoisomerase II activity def: "A molecular function phenotype in which the observed rate of DNA topoisomerase II activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0061505 ! DNA topoisomerase II activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0061505 ! DNA topoisomerase II activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-03-26T15:48:36Z [Term] id: FYPO:0002054 name: cut during cellular response to hydroxyurea def: "A cut phenotype that is observed when a cell is exposed to hydroxyurea. In a cut phenotype, a cell undergoes septation despite abnormal chromosome segregation, such that the septum physically divides the nucleus into two parts, and produces inviable daughter cells." [PomBase:mah] synonym: "cut during cellular response to HU" EXACT [PomBase:mah] synonym: "cut during cellular response to hydroxyurea during mitotic cell cycle" RELATED [PomBase:mah] synonym: "cut during cellular response to hydroxyurea during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003165 ! cut intersection_of: FYPO:0003165 ! cut intersection_of: during GO:0072711 ! cellular response to hydroxyurea relationship: during GO:0072711 ! cellular response to hydroxyurea created_by: midori creation_date: 2013-03-27T16:33:44Z [Term] id: FYPO:0002055 name: inviable cell at low temperature def: "A viability phenotype in which a cell is unable to survive at a low temperature at which wild-type cells survive." [PomBase:mah] comment: For fission yeast, low temperature usually corresponds to below 25 degrees Celsius. Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "essential at low temperature" RELATED [PomBase:mah] synonym: "lethal at low temperature" EXACT [PomBase:mah] is_a: FYPO:0000049 ! inviable cell created_by: midori creation_date: 2013-03-27T16:52:52Z [Term] id: FYPO:0002056 name: decreased mitochondrial translation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of mitochondrial translation is decreased." [PomBase:mah] comment: Note that this term should be used only when an experiment measures mitochondrial protein synthesis directly, e.g. by measuring incorporation of a radiolabeled amino acid. Consider annotating to 'decreased protein level' (FYPO:0000835) or one of its descendants. synonym: "decreased mitochondrial protein biosynthesis" EXACT [GO:0032543] synonym: "decreased mitochondrial protein synthesis" EXACT [GO:0032543] synonym: "decreased mitochondrial translation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased mitochondrial translation during vegetative growth" EXACT [PomBase:mah] synonym: "decreased rate of mitochondrial protein synthesis" RELATED [PomBase:mah] synonym: "reduced mitochondrial translation" EXACT [PomBase:mah] is_a: FYPO:0001798 ! decreased translation is_a: FYPO:0004528 ! abnormal mitochondrial translation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0032543 ! mitochondrial translation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0032543 ! mitochondrial translation created_by: midori creation_date: 2013-03-27T16:55:57Z [Term] id: FYPO:0002057 name: cell population viability def: "A cell population phenotype that reflects the proportion of the population that survive and develop normally." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate is_a: FYPO:0000003 ! cell population phenotype created_by: midori creation_date: 2013-04-04T13:48:22Z [Term] id: FYPO:0002058 name: viable cell population def: "A cell population phenotype in which cells in the population are viable." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. Note that a viable population may contain individual cells that are inviable. Usually it is difficult to detect inviable cells within an otherwise viable population, especially if population growth is simply assayed by OD increase in liquid culture or by colony formation on plates. If you have done an experiment that detects individual inviable cells, consider using the term 'mixed population including viable and inviable cells' (FYPO:0000908). subset: qc_do_not_manually_annotate is_a: FYPO:0002057 ! cell population viability created_by: midori creation_date: 2013-04-04T13:51:27Z [Term] id: FYPO:0002059 name: inviable cell population def: "A cell population phenotype in which none of the cells in the population are viable." [PomBase:mah] subset: qc_do_not_manually_annotate is_a: FYPO:0002057 ! cell population viability created_by: midori creation_date: 2013-04-04T13:54:32Z [Term] id: FYPO:0002060 name: viable vegetative cell population def: "A cell population phenotype in which cells in the population are viable in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "viable cell population during vegetative growth" EXACT [PomBase:mah] synonym: "viable vegetative cell population during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0002058 ! viable cell population created_by: midori creation_date: 2013-04-04T14:14:35Z [Term] id: FYPO:0002061 name: inviable vegetative cell population def: "A cell population phenotype in which all cells in the population are inviable in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "inviable cell population during vegetative growth" EXACT [PomBase:mah] synonym: "inviable vegetative cell population during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0002059 ! inviable cell population created_by: midori creation_date: 2013-04-04T14:15:53Z [Term] id: FYPO:0002062 name: normal cell growth def: "A cellular process phenotype in which the growth of a cell is normal. Cell growth is the process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GO:0016049, PomBase:mah] comment: Note that this term refers to growth at the level of any individual cell, and that it specifies only that increase in cell size due to metabolism is normal. Other aspects of the cell's biology may be abnormal, and other abnormalities may affect increase in cell number (population growth). Also see 'cell population growth phenotype' (FYPO:0000139) and its descendants. is_a: FYPO:0000627 ! normal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0016049 ! cell growth intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0016049 ! cell growth relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-04-05T14:44:50Z [Term] id: FYPO:0002063 name: abnormal 3'-5'-exoribonuclease activity def: "A molecular function phenotype in which the observed rate of a 3'-5'-exoribonuclease activity is abnormal." [PomBase:mah] is_a: FYPO:0003821 ! abnormal ribonuclease activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0000175 ! 3'-5'-exoribonuclease activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0000175 ! 3'-5'-exoribonuclease activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-04-05T15:31:48Z [Term] id: FYPO:0002064 name: abolished 3'-5'-exoribonuclease activity def: "A molecular function phenotype in which a 3'-5'-exoribonuclease activity is absent." [PomBase:mah] synonym: "3'-5'-exoribonuclease activity abolished" EXACT [PomBase:mah] is_a: FYPO:0002063 ! abnormal 3'-5'-exoribonuclease activity is_a: FYPO:0003164 ! abolished nuclease activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0000175 ! 3'-5'-exoribonuclease activity relationship: towards GO:0000175 ! 3'-5'-exoribonuclease activity created_by: midori creation_date: 2013-04-05T15:31:56Z [Term] id: FYPO:0002065 name: normal 3'-5'-exoribonuclease activity def: "A molecular function phenotype in which the observed rate of a 3'-5'-exoribonuclease activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0000175 ! 3'-5'-exoribonuclease activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0000175 ! 3'-5'-exoribonuclease activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-04-05T15:32:29Z [Term] id: FYPO:0002066 name: inviable elongated aseptate cell def: "A cell phenotype in which a cell has no septum, is elongated, and is inviable." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "inviable elongated aseptate cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable elongated aseptate cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable long aseptate cell" EXACT [PomBase:vw] is_a: FYPO:0000950 ! elongated aseptate cell is_a: FYPO:0001490 ! inviable elongated vegetative cell is_a: FYPO:0003931 ! inviable aseptate vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000949 ! aseptate intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000949 ! aseptate relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2013-04-17T14:42:57Z [Term] id: FYPO:0002067 name: slow cell population growth during recovery from stationary phase def: "A cell population phenotype in which a cell population grows more slowly than normal when the population has been in stationary phase and is then placed in conditions that allow recovery." [PomBase:mah] is_a: FYPO:0001234 ! slow vegetative cell population growth created_by: midori creation_date: 2013-04-17T15:03:47Z [Term] id: FYPO:0002068 name: growth auxotrophic for histidine def: "Auxotrophy in which a cell is unable to synthesize histidine, and therefore requires histidine in the medium for vegetative cell growth." [PomBase:mah] synonym: "growth auxotrophic for histidine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "growth auxotrophic for histidine during vegetative growth" EXACT [PomBase:mah] synonym: "histidine auxotrophy" EXACT [PomBase:mah] is_a: FYPO:0000128 ! auxotrophy is_a: PATO:0000422 ! auxotrophic intersection_of: PATO:0000422 ! auxotrophic intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:15971 ! L-histidine relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:15971 ! L-histidine created_by: midori creation_date: 2013-04-17T16:06:19Z [Term] id: FYPO:0002069 name: mislocalized nucleus def: "A physical cellular phenotype in which a cell has a nucleus in an abnormal location. The normal location is at the midpoint of the long axis of the cell." [PomBase:mah] subset: qc_do_not_manually_annotate synonym: "abnormal nucleus location" EXACT [PomBase:mah] synonym: "abnormal nucleus position" EXACT [PomBase:mah] synonym: "displaced nucleus" EXACT [PomBase:vw] synonym: "mislocalised nucleus" EXACT [PomBase:mah] synonym: "misplaced nuclei" EXACT [PomBase:vw] synonym: "misplaced nucleus" EXACT [PomBase:vw] synonym: "nuclear position: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000136 ! cellular physical quality phenotype is_a: PATO:0000628 ! mislocalised intersection_of: PATO:0000628 ! mislocalised intersection_of: inheres_in GO:0005634 ! nucleus relationship: inheres_in GO:0005634 ! nucleus relationship: output_of FYPO:0000517 ! abnormal nucleus localization created_by: midori creation_date: 2013-04-17T16:12:37Z [Term] id: FYPO:0002070 name: normal nucleus location def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which a cell has a nucleus in the normal location at the midpoint of the long axis of the cell." [PomBase:mah] synonym: "normal nuclear location" EXACT [PomBase:mah] synonym: "normal nucleus location during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal nucleus location during vegetative growth" EXACT [PomBase:mah] synonym: "normal nucleus position" EXACT [PomBase:mah] synonym: "normally localized nucleus" EXACT [PomBase:mah] is_a: FYPO:0001233 ! normal subcellular component is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position intersection_of: inheres_in GO:0005634 ! nucleus intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0005634 ! nucleus relationship: output_of FYPO:0001389 ! normal nucleus localization relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-04-17T16:16:17Z [Term] id: FYPO:0002071 name: mislocalized nucleus during vegetative growth def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which a cell has a nucleus in an abnormal location. The normal location of a single nucleus is at the midpoint of the long axis of the cell (during mitotic telophase, daughter nuclei normally move away from the cell division site)." [PomBase:mah] subset: qc_do_not_manually_annotate synonym: "abnormal nucleus location during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal nucleus position during vegetative growth" EXACT [PomBase:mah] synonym: "displaced nucleus during vegetative growth" EXACT [PomBase:vw] synonym: "mislocalised nucleus during vegetative growth" EXACT [PomBase:mah] synonym: "mislocalized nucleus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "mislocalized nucleus during vegetative growth" EXACT [PomBase:mah] synonym: "misplaced nuclei during vegetative growth" EXACT [PomBase:vw] synonym: "misplaced nucleus during vegetative growth" EXACT [PomBase:vw] is_a: FYPO:0001321 ! cellular physical quality phenotype during vegetative growth is_a: FYPO:0002069 ! mislocalized nucleus intersection_of: PATO:0000628 ! mislocalised intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005634 ! nucleus relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005634 ! nucleus relationship: output_of FYPO:0001338 ! abnormal nucleus localization during vegetative growth created_by: midori creation_date: 2013-04-17T16:20:51Z [Term] id: FYPO:0002072 name: mislocalized nucleus in prospore def: "A physical cellular phenotype in which a prospore has a nucleus in an abnormal location. The normal location is at the midpoint of the long axis of the cell." [PomBase:mah] synonym: "abnormal nucleus location in prospore" EXACT [PomBase:mah] synonym: "abnormal nucleus position in prospore" EXACT [PomBase:mah] synonym: "displaced nucleus in prospore" EXACT [PomBase:vw] synonym: "displaced nucleus prospore" EXACT [PomBase:vw] synonym: "mislocalised nucleus in prospore" EXACT [PomBase:mah] synonym: "mislocalized nucleus in forespore" EXACT [PomBase:mah] synonym: "mislocalized nucleus in prospore" EXACT [PomBase:mah] synonym: "mislocalized prospore nucleus" EXACT [PomBase:mah] synonym: "misplaced prospore nuclei" EXACT [PomBase:vw] synonym: "misplaced prospore nucleus" EXACT [PomBase:vw] is_a: FYPO:0002069 ! mislocalized nucleus intersection_of: PATO:0000628 ! mislocalised intersection_of: inheres_in GO:0005634 ! nucleus intersection_of: part_of GO:0042764 ! ascospore-type prospore relationship: inheres_in GO:0005634 ! nucleus relationship: output_of FYPO:0000942 ! abnormal nucleus localization in prospore relationship: part_of GO:0042764 ! ascospore-type prospore created_by: midori creation_date: 2013-04-17T16:23:48Z [Term] id: FYPO:0002073 name: protein mislocalized to nucleus during cellular response to copper ion def: "A cell phenotype in which a protein that is not normally found in the nucleus is observed there during a cellular response to copper ions." [PomBase:mah] comment: Note that this term can be used to annotate any case where a protein is found in the nucleus in a mutant, but not in wild type. In some cases, there may be enough additional information to annotate to 'abnormal protein localization' (FYPO:0000443) or one of its descendants. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "ectopic protein localization to nucleus during cellular response to copper" EXACT [PomBase:vw] synonym: "nuclear protein accumulation in response to copper" RELATED [PomBase:al] synonym: "protein mislocalised to nucleus during cellular response to copper ion" EXACT [PomBase:mah] synonym: "protein mislocalised to nucleus during cellular response to copper ion during vegetative growth" EXACT [PomBase:mah] synonym: "protein mislocalized to nucleus during cellular response to copper" EXACT [PomBase:mah] synonym: "protein mislocalized to nucleus during cellular response to copper during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein mislocalized to nucleus during cellular response to copper ion during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000784 ! protein mislocalized to nucleus during vegetative growth intersection_of: PATO:0000628 ! mislocalised intersection_of: exists_during GO:0071280 ! cellular response to copper ion intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CHEBI:36080 ! protein intersection_of: towards GO:0005634 ! nucleus relationship: exists_during GO:0071280 ! cellular response to copper ion relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CHEBI:36080 ! protein relationship: towards GO:0005634 ! nucleus created_by: midori creation_date: 2013-04-24T12:06:43Z [Term] id: FYPO:0002074 name: inviable cell population at high temperature def: "A cell population phenotype in which none of the cells in the population are viable at a high temperature." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. is_obsolete: true created_by: midori creation_date: 2013-04-24T12:29:02Z [Term] id: FYPO:0002075 name: inviable vegetative cell population at high temperature def: "A cell population phenotype in which none of the cells in the population are viable at a high temperature in the vegetative growth phase of the life cycle." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. is_obsolete: true replaced_by: FYPO:0002061 created_by: midori creation_date: 2013-04-24T12:31:01Z [Term] id: FYPO:0002076 name: inviable elongated cell with fragmented nucleus and increased septum thickness def: "A cell phenotype in which a cell is elongated, has a nucleus that is broken into multiple small fragments, forms a septum that is thicker than normal, and is inviable." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "elongated inviable cell with fragmented nuclear material and increased septum thickness" EXACT [PomBase:al] synonym: "elongated inviable cell with fragmented nuclei and increased septum thickness" EXACT [PomBase:al] synonym: "elongated inviable cell with fragmented nucleus and increased septum thickness" EXACT [PomBase:mah] synonym: "elongated inviable cell with fragmented nucleus and increased septum thickness during vegetative growth" EXACT [PomBase:mah] synonym: "inviable elongated cell with fragmented nucleus and increased septum thickness during mitotic cell cycle" RELATED [PomBase:mah] synonym: "long inviable cell with fragmented nucleus and increased septum thickness" EXACT [PomBase:vw] is_a: FYPO:0002889 ! inviable elongated vegetative cell with abnormal septum intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0001406 ! increased septum thickness intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0001919 ! fragmented nucleus relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0001406 ! increased septum thickness relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0001919 ! fragmented nucleus created_by: midori creation_date: 2013-04-24T12:48:44Z [Term] id: FYPO:0002077 name: sensitive to low osmolarity def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to conditions of low osmolarity." [PomBase:mah] synonym: "hypersensitive to low osmolarity" EXACT [PomBase:mah] synonym: "sensitive to hypo-osmotic conditions" EXACT [PomBase:mah] synonym: "sensitive to hypoosmotic conditions" EXACT [PomBase:al] synonym: "sensitive to hypotonic conditions" RELATED [PomBase:mah] synonym: "sensitive to low osmolarity during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to low osmolarity during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000270 ! sensitive to osmotic stress created_by: midori creation_date: 2013-04-24T14:41:45Z [Term] id: FYPO:0002078 name: sensitive to calcium during cellular hypotonic response def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to calcium during a cellular hypotonic response. Cells stop growing (and may die) at a concentration of calcium ions that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to calcium during cellular hypotonic response" EXACT [PomBase:mah] synonym: "sensitive to calcium during cellular hypoosmotic response" EXACT [PomBase:al] synonym: "sensitive to calcium during cellular hypotonic response during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to calcium during cellular hypotonic response during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to calcium ions during cellular hypotonic response" EXACT [PomBase:mah] is_a: FYPO:0000098 ! sensitive to calcium intersection_of: FYPO:0000098 ! sensitive to calcium intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: during GO:0071476 ! cellular hypotonic response intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:29108 ! calcium(2+) relationship: during GO:0071476 ! cellular hypotonic response relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:29108 ! calcium(2+) created_by: midori creation_date: 2013-04-24T14:57:12Z [Term] id: FYPO:0002079 name: normal growth on calcium ion during cellular hypotonic response def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing calcium ions during a cellular hypotonic response." [PomBase:mah] synonym: "normal cell population growth in presence of calcium ions during cellular hypotonic response" EXACT [PomBase:mah] synonym: "normal cell population growth on calcium during cellular hypotonic response" EXACT [PomBase:mah] synonym: "normal cell population growth on calcium ion during cellular hypoosmotic response" EXACT [PomBase:al] synonym: "normal cell population growth on calcium ion during cellular hypotonic response" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cell population growth on excess calcium during cellular hypotonic response" EXACT [PomBase:al] synonym: "normal cellular response to calcium ion during cellular hypotonic response" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on calcium ion during cellular hypotonic response" EXACT [PomBase:mah] is_a: FYPO:0001020 ! normal growth on calcium ion is_a: FYPO:0001021 ! normal growth during cellular response to osmotic stress intersection_of: FYPO:0001020 ! normal growth on calcium ion intersection_of: happens_during GO:0071476 ! cellular hypotonic response relationship: happens_during GO:0071476 ! cellular hypotonic response created_by: midori creation_date: 2013-04-24T14:59:06Z [Term] id: FYPO:0002080 name: sensitive to TPCK def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to N-tosyl-L-phenylalanyl chloromethyl ketone (TPCK). Cells stop growing (and may die) at a concentration of TPCK that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to TPCK" EXACT [PomBase:mah] synonym: "sensitive to N-tosyl-L-phenylalanyl chloromethyl ketone" EXACT [CHEBI:9642, PomBase:mah] synonym: "sensitive to TPCK during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to TPCK during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001695 ! sensitive to protease inhibitor intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:9642 ! N-tosyl-L-phenylalanyl chloromethyl ketone relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:9642 ! N-tosyl-L-phenylalanyl chloromethyl ketone created_by: midori creation_date: 2013-05-01T15:43:45Z [Term] id: FYPO:0002081 name: normal growth on TPCK def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing N-tosyl-L-phenylalanyl chloromethyl ketone (TPCK)." [PomBase:mah] synonym: "normal cell population growth in presence of TPCK" EXACT [PomBase:mah] synonym: "normal cell population growth on N-tosyl-L-phenylalanyl chloromethyl ketone" EXACT [CHEBI:9642] synonym: "normal cell population growth on TPCK" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to TPCK" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on TPCK" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:9642 ! N-tosyl-L-phenylalanyl chloromethyl ketone relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:9642 ! N-tosyl-L-phenylalanyl chloromethyl ketone created_by: midori creation_date: 2013-05-01T15:45:35Z [Term] id: FYPO:0002082 name: increased protein ubiquitination def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of ubiquitination of one or more specific proteins, or of specific protein sites, is increased." [PomBase:mah] comment: Consider also annotating to 'increased level of ubiquitinated protein in cell during vegetative growth' (FYPO:0002774). synonym: "increased protein ubiquitination during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein ubiquitination during vegetative growth" EXACT [PomBase:mah] synonym: "increased protein ubiquitinylation" EXACT [GO:0016567, PomBase:mah] synonym: "increased protein ubiquitylation" EXACT [GO:0016567, PomBase:mah] is_a: FYPO:0000547 ! increased protein modification during vegetative growth is_a: FYPO:0000905 ! abnormal protein ubiquitination intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0016567 ! protein ubiquitination relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0016567 ! protein ubiquitination created_by: midori creation_date: 2013-05-01T15:54:55Z [Term] id: FYPO:0002083 name: inviable swollen elongated cell with enlarged nucleus def: "A cell morphology phenotype in which a vegetative cell is inviable, is swollen, and is longer than normal, and in which the nucleus is larger than normal. In a swollen cell, both length and diameter are greater than normal, although the cell is only considered elongated if the length:width ratio is also greater than normal." [PMID:19074598, PomBase:mah] comment: The distinction between this phenotype and centrally constricted (dumbbell-shaped) cells (FYPO:0000779) is that swollen elongated cells do not have a constriction along the long axis. Swollen elongated cells may have a uniform diameter, or may be swollen only around the nucleus. synonym: "inviable elongated cell with enlarged nucleus and increased cell volume" EXACT [PomBase:mah] synonym: "inviable enlarged elongated cell with enlarged nucleus" RELATED [PomBase:mah] synonym: "inviable large elongated cell with enlarged nucleus" RELATED [PomBase:vw] synonym: "inviable swollen elongated vegetative cell with enlarged nucleus" EXACT [PomBase:mah] synonym: "swollen elongated cell with enlarged nucleus" EXACT [PomBase:mah] synonym: "swollen elongated vegetative cell with enlarged nucleus" EXACT [PomBase:mah] is_a: FYPO:0002251 ! inviable swollen elongated vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000025 ! swollen cell intersection_of: has_part FYPO:0000344 ! enlarged nucleus during vegetative growth intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000025 ! swollen cell relationship: has_part FYPO:0000344 ! enlarged nucleus during vegetative growth relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2013-05-01T16:06:42Z [Term] id: FYPO:0002084 name: swollen stubby cell def: "A cell morphology phenotype in which a vegetative cell has a larger volume and cell diameter, but shorter cell length, than normal." [PomBase:mah] synonym: "enlarged stubby cell" RELATED [PomBase:mah] synonym: "large stubby cell" RELATED [PomBase:vw] synonym: "stubby cell with increased cell size" RELATED [PomBase:vw] synonym: "stubby cell with increased cell volume" EXACT [PomBase:mah] synonym: "swollen stubby vegetative cell" RELATED [PomBase:mah] synonym: "swollen watermelon-shaped cell" EXACT [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000024 ! stubby cell intersection_of: has_part FYPO:0000025 ! swollen cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000024 ! stubby cell relationship: has_part FYPO:0000025 ! swollen cell created_by: midori creation_date: 2013-05-01T16:10:39Z [Term] id: FYPO:0002085 name: normal vegetative cell growth def: "A cellular process phenotype in which the growth of a cell is normal (i.e. indistinguishable from wild type) in the vegetative growth phase of the life cycle. Cell growth is the process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GO:0016049, PomBase:mah] comment: Note that this term refers to growth at the level of any individual cell, and that it specifies only that increase in cell size due to metabolism is normal. Other aspects of the cell's biology may be abnormal, and other abnormalities may affect increase in cell number (population growth). Also see 'cell population growth phenotype' (FYPO:0000139) and its descendants. is_a: FYPO:0001319 ! normal cellular process during vegetative growth is_a: FYPO:0002062 ! normal cell growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0016049 ! cell growth intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0016049 ! cell growth relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-05-01T16:24:01Z [Term] id: FYPO:0002086 name: exocytic vesicles present in greater numbers def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells contain more exocytic vesicles than normal." [PomBase:mah] synonym: "accumulation of exocytic vesicles" RELATED [PomBase:vw] synonym: "additional exocytic vesicles present" EXACT [PomBase:mah] synonym: "exocytic vesicles present in greater numbers during mitotic cell cycle" RELATED [PomBase:mah] synonym: "exocytic vesicles present in greater numbers during vegetative growth" EXACT [PomBase:mah] synonym: "exocytotic vesicles present in greater numbers" EXACT [GO:0070382] synonym: "extra exocytic vesicles" EXACT [PomBase:mah] synonym: "post-Golgi secretory vesicles present in greater numbers" RELATED [PomBase:vw] is_a: FYPO:0003416 ! cytoplasmic vesicles present in greater numbers intersection_of: PATO:0002002 ! has extra parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0070382 ! exocytic vesicle relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: output_of FYPO:0002089 ! abnormal exocytosis relationship: towards GO:0070382 ! exocytic vesicle created_by: midori creation_date: 2013-05-01T16:39:50Z [Term] id: FYPO:0002087 name: exocytic vesicles present in greater numbers at cell tip during cell growth def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells contain more exocytic vesicles at one or both cell tips than normal when the cell is growing." [PomBase:mah] synonym: "accumulation of exocytic vesicles at cell tip during cell growth" RELATED [PomBase:vw] synonym: "additional exocytic vesicles present at cell tip during cell growth" EXACT [PomBase:mah] synonym: "exocytic vesicles present in greater numbers at cell tip during cell growth during mitotic cell cycle" RELATED [PomBase:mah] synonym: "exocytic vesicles present in greater numbers during vegetative growth at cell tip during cell growth" EXACT [PomBase:mah] synonym: "exocytotic vesicles present in greater numbers at cell tip during cell growth" EXACT [GO:0070382] synonym: "extra exocytic vesicles at cell tip during cell growth" EXACT [PomBase:mah] synonym: "post-Golgi secretory vesicles present in greater numbers at cell tip during cell growth" RELATED [PomBase:vw] is_a: FYPO:0002086 ! exocytic vesicles present in greater numbers intersection_of: PATO:0002002 ! has extra parts of type intersection_of: exists_during GO:0016049 ! cell growth intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: part_of GO:0035838 ! growing cell tip intersection_of: towards GO:0070382 ! exocytic vesicle relationship: exists_during GO:0016049 ! cell growth relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: part_of GO:0035838 ! growing cell tip relationship: towards GO:0070382 ! exocytic vesicle created_by: midori creation_date: 2013-05-01T16:43:15Z [Term] id: FYPO:0002088 name: exocytic vesicles present in greater numbers at barrier septum during septation def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells contain more exocytic vesicles than normal near the barrier septum while the cell is undergoing septation." [PomBase:mah] synonym: "accumulation of exocytic vesicles at barrier septum during septation" RELATED [PomBase:vw] synonym: "additional exocytic vesicles present at barrier septum during septation" EXACT [PomBase:mah] synonym: "exocytic vesicles present in greater numbers at barrier septum during septation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "exocytic vesicles present in greater numbers at barrier septum during septation during vegetative growth" EXACT [PomBase:mah] synonym: "exocytotic vesicles present in greater numbers at barrier septum during septation" EXACT [GO:0070382] synonym: "extra exocytic vesicles at barrier septum during septation" EXACT [PomBase:mah] synonym: "post-Golgi secretory vesicles present in greater numbers at barrier septum during septation" RELATED [PomBase:vw] is_a: FYPO:0002086 ! exocytic vesicles present in greater numbers intersection_of: PATO:0002002 ! has extra parts of type intersection_of: exists_during GO:0000917 ! barrier septum assembly intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: part_of GO:0000935 ! barrier septum intersection_of: towards GO:0070382 ! exocytic vesicle relationship: exists_during GO:0000917 ! barrier septum assembly relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: part_of GO:0000935 ! barrier septum relationship: towards GO:0070382 ! exocytic vesicle created_by: midori creation_date: 2013-05-01T16:44:51Z [Term] id: FYPO:0002089 name: abnormal exocytosis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which exocytosis is abnormal. Exocytosis is the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. A phenotype may affect exocytosis of all cargoes, or of specific cargo such as a particular protein." [GO:0006887, PomBase:mah] synonym: "abnormal exocytosis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal exocytosis during vegetative growth" EXACT [PomBase:mah] synonym: "exocytosis defects" EXACT [PomBase:vw] is_a: FYPO:0000213 ! abnormal vesicle-mediated transport during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006887 ! exocytosis intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006887 ! exocytosis relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-05-01T16:47:54Z [Term] id: FYPO:0002090 name: lagging chromosomes def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which homologous chromosomes or sister chromatids do not move towards the spindle poles at the same time during nuclear division, but instead one or more chromosomes remain distant from the spindle pole after the bulk of the DNA has separated. Segregation may stop before completing separation of chromosomes, or may eventually be completed." [PomBase:mah] synonym: "chromosome segregation defects, lagging chromosomes" EXACT [PomBase:mah] is_a: FYPO:0000029 ! abnormal chromosome segregation created_by: midori creation_date: 2013-05-01T16:58:26Z [Term] id: FYPO:0002091 name: lagging meiotic chromosomes def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which homologous chromosomes or sister chromatids do not move towards the spindle poles at the same time during meiosis I or meiosis II, but instead one or more chromosomes remain distant from the spindle pole after the bulk of the DNA has separated. Segregation may stop before completing separation of chromosomes, or may eventually be completed." [PomBase:mah] synonym: "chromosome segregation defects, lagging meiotic chromosomes" EXACT [PomBase:mah] synonym: "lagging chromosomes during meiosis" EXACT [PomBase:mah] synonym: "meiotic chromosome segregation defects, lagging chromosomes" EXACT [PomBase:mah] is_a: FYPO:0000151 ! abnormal meiotic chromosome segregation is_a: FYPO:0002090 ! lagging chromosomes created_by: midori creation_date: 2013-05-01T16:59:42Z [Term] id: FYPO:0002092 name: abnormal meiotic sister chromatid cohesion def: "A cellular process phenotype in which cohesion between sister chromatids is abnormal during meiosis." [PomBase:mah] synonym: "abnormal sister chromatid cohesion during meiosis" EXACT [PomBase:mah] is_a: FYPO:0000641 ! abnormal chromosome organization is_a: FYPO:0002739 ! abnormal meiotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0051177 ! meiotic sister chromatid cohesion intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0051177 ! meiotic sister chromatid cohesion relationship: part_of FYPO:0000151 ! abnormal meiotic chromosome segregation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-05-01T17:08:24Z [Term] id: FYPO:0002093 name: decreased meiotic sister chromatid cohesion def: "A cellular process phenotype in which cohesion between sister chromatids is decreased during meiosis." [PomBase:mah] synonym: "abnormal sister chromatid cohesion during meiosis" EXACT [PomBase:mah] synonym: "reduced meiotic sister chromatid cohesion" EXACT [PomBase:mah] is_a: FYPO:0002092 ! abnormal meiotic sister chromatid cohesion is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0051177 ! meiotic sister chromatid cohesion relationship: inheres_in GO:0051177 ! meiotic sister chromatid cohesion created_by: midori creation_date: 2013-05-01T17:09:24Z [Term] id: FYPO:0002094 name: normal meiotic sister chromatid cohesion def: "A cellular process phenotype in which cohesion between sister chromatids is normal (i.e. indistinguishable from wild type) during meiosis." [PomBase:mah] synonym: "normal sister chromatid cohesion during meiosis" EXACT [PomBase:mah] is_a: FYPO:0000627 ! normal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0051177 ! meiotic sister chromatid cohesion intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0051177 ! meiotic sister chromatid cohesion relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-05-01T17:12:15Z [Term] id: FYPO:0002095 name: increased protein phosphorylation during cellular response to DNA damage def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a greater extent than normal during a cellular response to a DNA damage stimulus." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein phosphorylation during cellular response to DNA damage during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein phosphorylation during cellular response to DNA damage during vegetative growth" EXACT [PomBase:mah] synonym: "increased protein phosphorylation during cellular response to DNA damaging agent" RELATED [PomBase:al] synonym: "increased protein phosphorylation during response to DNA damage stimulus" EXACT [GO:0006974] is_a: FYPO:0001038 ! increased protein phosphorylation during vegetative growth intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0006974 ! cellular response to DNA damage stimulus intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0006974 ! cellular response to DNA damage stimulus relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2013-05-02T11:57:21Z [Term] id: FYPO:0002096 name: increased protein phosphorylation during cellular response to hydroxyurea def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a greater extent than normal during a cellular response to hydroxyurea." [PomBase:mah] comment: Also consider annotating to 'increased protein phosphorylation during cellular response to DNA damage' (FYPO:0002095). When using this term, it is recommended to note the specific protein(s) affected. synonym: "increased protein phosphorylation during cellular response to HU" EXACT [PomBase:mah] synonym: "increased protein phosphorylation during cellular response to hydroxyurea during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein phosphorylation during cellular response to hydroxyurea during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001038 ! increased protein phosphorylation during vegetative growth intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: happens_during GO:0072711 ! cellular response to hydroxyurea intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: happens_during GO:0072711 ! cellular response to hydroxyurea relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2013-05-02T12:12:21Z [Term] id: FYPO:0002097 name: decreased protein kinase activity during cellular response to hydroxyurea def: "A molecular function phenotype in which the observed rate of a protein kinase activity is decreased during a cellular response to hydroxyurea." [PomBase:mah] synonym: "decreased protein kinase activity during cellular response to HU" EXACT [PomBase:mah] synonym: "reduced protein kinase activity during cellular response to HU" EXACT [PomBase:mah] synonym: "reduced protein kinase activity during cellular response to hydroxyurea" EXACT [PomBase:mah] is_a: FYPO:0001382 ! decreased protein kinase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: during GO:0072711 ! cellular response to hydroxyurea intersection_of: inheres_in GO:0004672 ! protein kinase activity relationship: during GO:0072711 ! cellular response to hydroxyurea relationship: inheres_in GO:0004672 ! protein kinase activity created_by: midori creation_date: 2013-05-02T12:21:11Z [Term] id: FYPO:0002098 name: decreased protein phosphorylation during cellular response to hydroxyurea def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal during a cellular response to hydroxyurea." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein phosphorylation during cellular response to HU" EXACT [PomBase:mah] synonym: "decreased protein phosphorylation during cellular response to hydroxyurea during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein phosphorylation during cellular response to hydroxyurea during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein phosphorylation during cellular response to HU" EXACT [PomBase:mah] synonym: "reduced protein phosphorylation during cellular response to hydroxyurea" EXACT [PomBase:mah] is_a: FYPO:0001838 ! decreased protein phosphorylation during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: happens_during GO:0072711 ! cellular response to hydroxyurea intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: happens_during GO:0072711 ! cellular response to hydroxyurea relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2013-05-02T12:23:07Z [Term] id: FYPO:0002099 name: normal protein phosphorylation during cellular response to hydroxyurea def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins is normal (i.e. indistinguishable from wild type) during a cellular response to hydroxyurea." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein phosphorylation during cellular response to HU" EXACT [PomBase:mah] synonym: "normal protein phosphorylation during cellular response to hydroxyurea during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein phosphorylation during cellular response to hydroxyurea during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000776 ! normal protein phosphorylation during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: happens_during GO:0072711 ! cellular response to hydroxyurea intersection_of: inheres_in GO:0006468 ! protein phosphorylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: happens_during GO:0072711 ! cellular response to hydroxyurea relationship: inheres_in GO:0006468 ! protein phosphorylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-05-02T12:25:08Z [Term] id: FYPO:0002100 name: abnormal ATP-dependent 3'-5' DNA helicase activity def: "A molecular function phenotype in which the observed rate of an ATP-dependent 3'-5' DNA helicase activity is abnormal." [PomBase:mah] is_a: FYPO:0001167 ! abnormal ATPase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0043140 ! ATP-dependent 3'-5' DNA helicase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0043140 ! ATP-dependent 3'-5' DNA helicase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-05-02T12:39:58Z [Term] id: FYPO:0002101 name: abolished ATP-dependent 3'-5' DNA helicase activity def: "A molecular function phenotype in which an ATP-dependent 3'-5' DNA helicase activity is absent." [PomBase:mah] synonym: "ATP-dependent 3'-5' DNA helicase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0002100 ! abnormal ATP-dependent 3'-5' DNA helicase activity is_a: FYPO:0003674 ! abolished ATPase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0043140 ! ATP-dependent 3'-5' DNA helicase activity relationship: towards GO:0043140 ! ATP-dependent 3'-5' DNA helicase activity created_by: midori creation_date: 2013-05-02T12:40:04Z [Term] id: FYPO:0002102 name: normal DNA damage checkpoint during cellular response to UV def: "A cell cycle checkpoint phenotype in which any DNA damage checkpoint is normal (i.e. indistinguishable from wild type) when the cell is exposed to ultraviolet light. A DNA damage checkpoint normally regulates progression through the cell cycle in response to DNA damage." [PomBase:mah] synonym: "normal DNA damage checkpoint activation during cellular response to UV" EXACT [PomBase:al] synonym: "normal DNA damage checkpoint during cellular response to ultraviolet light" EXACT [PomBase:mah] synonym: "normal DNA damage checkpoint during cellular response to UV during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal DNA damage checkpoint during cellular response to UV during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001705 ! normal mitotic DNA damage checkpoint is_a: FYPO:0004014 ! normal mitotic cell cycle regulation during cellular response to UV intersection_of: PATO:0000001 ! quality intersection_of: during GO:0034644 ! cellular response to UV intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000077 ! DNA damage checkpoint intersection_of: qualifier PATO:0000461 ! normal relationship: during GO:0034644 ! cellular response to UV relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000077 ! DNA damage checkpoint relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-05-02T13:15:58Z [Term] id: FYPO:0002103 name: inviable swollen mononucleate monoseptate vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell has one nucleus and one septum, and is swollen and inviable. In a swollen cell, both length and diameter are greater than normal, although the cell is only considered elongated if the length:width ratio is also greater than normal." [PomBase:mah] synonym: "inviable enlarged mononucleate monoseptate vegetative cell" EXACT [PomBase:mah] synonym: "inviable large mononucleate monoseptate vegetative cell" EXACT [PomBase:mah] synonym: "inviable mononucleate monoseptate vegetative cell with increased cell volume" EXACT [PomBase:mah] synonym: "inviable swollen mononucleate monoseptate cell" EXACT [PomBase:mah] synonym: "inviable swollen mononucleate monoseptate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "mononucleate monoseptate cell during vegetative growth" EXACT [PomBase:mah] synonym: "swollen mononucleate monoseptate cell" EXACT [PomBase:mah] is_a: FYPO:0002303 ! inviable mononucleate monoseptate vegetative cell is_a: FYPO:0002414 ! inviable swollen vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000025 ! swollen cell intersection_of: has_part FYPO:0000060 ! mononucleate vegetative cell intersection_of: has_part FYPO:0001225 ! monoseptate intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000025 ! swollen cell relationship: has_part FYPO:0000060 ! mononucleate vegetative cell relationship: has_part FYPO:0001225 ! monoseptate relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2013-05-07T12:15:31Z [Term] id: FYPO:0002104 name: viable vegetative cell with normal cell shape def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell has a normal shape and is viable." [PomBase:mah] synonym: "viable cell with normal cell shape during vegetative growth" EXACT [PomBase:mah] synonym: "viable vegetative cell with normal cell shape during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001125 ! normal vegetative cell shape is_a: FYPO:0001491 ! viable vegetative cell created_by: midori creation_date: 2013-05-07T12:22:30Z [Term] id: FYPO:0002105 name: inviable vegetative cell with normal cell shape def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell has a normal shape but is inviable." [PomBase:mah] synonym: "inviable cell with normal cell shape during vegetative growth" EXACT [PomBase:mah] synonym: "inviable vegetative cell with normal cell shape during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001125 ! normal vegetative cell shape is_a: FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2013-05-07T12:27:52Z [Term] id: FYPO:0002106 name: viable stubby vegetative cell def: "A cell morphology phenotype in which a vegetatively growing cell is viable, but the cell diameter is larger than normal and the cell length is shorter than normal." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "stubby viable cell during vegetative growth" EXACT [PomBase:mah] synonym: "stubby viable vegetative cell" EXACT [PomBase:mah] synonym: "viable stubby vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "viable watermelon-shaped vegetative cell" EXACT [PMID:9108274, PomBase:vw] is_a: FYPO:0002197 ! viable vegetative cell with abnormal cell shape intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000024 ! stubby cell intersection_of: has_part FYPO:0001491 ! viable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000024 ! stubby cell relationship: has_part FYPO:0001491 ! viable vegetative cell created_by: midori creation_date: 2013-05-07T12:34:55Z [Term] id: FYPO:0002107 name: inviable stubby vegetative cell def: "A cell morphology phenotype in which a vegetatively growing cell is inviable, and the cell diameter is larger than normal and the cell length is shorter than normal." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "essential; stubby vegetative cell" RELATED [PomBase:mah] synonym: "inviable stubby vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable watermelon-shaped vegetative cell" EXACT [PomBase:mah] synonym: "stubby inviable cell during vegetative growth" EXACT [PomBase:mah] synonym: "stubby inviable vegetative cell" EXACT [PomBase:mah] is_a: FYPO:0002451 ! inviable vegetative cell with abnormal cell shape intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000024 ! stubby cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000024 ! stubby cell relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2013-05-07T12:36:29Z [Term] id: FYPO:0002108 name: viable tapered cell def: "A cell morphology phenotype in which a cell is viable, and tapers at one end to a diameter smaller than the other. The cell diameter at the narrow end is smaller than that of a wild-type cell." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "viable bottle-shaped cell" EXACT [PomBase:vw] synonym: "viable bottle/skittle cell" EXACT [PomBase:mah] synonym: "viable skittle-shaped cell" EXACT [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000014 ! tapered cell intersection_of: has_part FYPO:0000124 ! viable cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000014 ! tapered cell relationship: has_part FYPO:0000124 ! viable cell created_by: midori creation_date: 2013-05-07T12:41:18Z [Term] id: FYPO:0002109 name: inviable tapered cell def: "A cell morphology phenotype in which a cell is inviable, and tapers at one end to a diameter smaller than the other. The cell diameter at the narrow end is smaller than that of a wild-type cell." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "essential; tapered cell" RELATED [PomBase:mah] synonym: "inviable bottle-shaped cell" EXACT [PomBase:vw] synonym: "inviable bottle/skittle cell" EXACT [PomBase:mah] synonym: "skittle-inviable shaped cell" EXACT [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000014 ! tapered cell intersection_of: has_part FYPO:0000049 ! inviable cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000014 ! tapered cell relationship: has_part FYPO:0000049 ! inviable cell created_by: midori creation_date: 2013-05-07T12:41:24Z [Term] id: FYPO:0002110 name: viable tapered vegetative cell def: "A cell morphology phenotype in which a vegetatively growing cell is viable, and tapers at one end to a diameter smaller than the other. The cell diameter at the narrow end is smaller than that of a wild-type cell." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "viable bottle-shaped vegetative cell" EXACT [PomBase:vw] synonym: "viable bottle-shaped vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "viable bottle/skittle vegetative cell" EXACT [PomBase:mah] synonym: "viable skittle-shaped vegetative cell" EXACT [PomBase:mah] synonym: "viable tapered cell during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002108 ! viable tapered cell is_a: FYPO:0002197 ! viable vegetative cell with abnormal cell shape intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000014 ! tapered cell intersection_of: has_part FYPO:0001491 ! viable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000014 ! tapered cell relationship: has_part FYPO:0001491 ! viable vegetative cell created_by: midori creation_date: 2013-05-07T12:42:50Z [Term] id: FYPO:0002111 name: inviable tapered vegetative cell def: "A cell morphology phenotype in which a vegetatively growing cell is inviable, and tapers at one end to a diameter smaller than the other. The cell diameter at the narrow end is smaller than that of a wild-type cell." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "essential; tapered vegetative cell" RELATED [PomBase:mah] synonym: "inviable bottle-shaped vegetative cell" EXACT [PomBase:vw] synonym: "inviable bottle-shaped vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable bottle/skittle vegetative cell" EXACT [PomBase:mah] synonym: "inviable skittle-shaped vegetative cell" EXACT [PomBase:mah] synonym: "inviable tapered cell during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002109 ! inviable tapered cell is_a: FYPO:0002451 ! inviable vegetative cell with abnormal cell shape intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000014 ! tapered cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000014 ! tapered cell relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2013-05-07T12:43:02Z [Term] id: FYPO:0002112 name: viable curved vegetative cell def: "A cell morphology phenotype in which a vegetatively growing cell is viable, and is curved along the long axis. In a curved cell, the long axis follows a smooth bend rather than a straight line." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "curved viable cell" EXACT [PomBase:mah] synonym: "viable curved cell" EXACT [PomBase:mah] synonym: "viable curved cell during vegetative growth" EXACT [PomBase:mah] synonym: "viable curved vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0002197 ! viable vegetative cell with abnormal cell shape intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000016 ! curved vegetative cell intersection_of: has_part FYPO:0001491 ! viable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000016 ! curved vegetative cell relationship: has_part FYPO:0001491 ! viable vegetative cell created_by: midori creation_date: 2013-05-07T12:50:59Z [Term] id: FYPO:0002113 name: inviable curved vegetative cell def: "A cell morphology phenotype in which a vegetatively growing cell is inviable, and is curved along the long axis. In a curved cell, the long axis follows a smooth bend rather than a straight line." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "curved inviable cell" EXACT [PomBase:mah] synonym: "essential; curved vegetative cell" RELATED [PomBase:mah] synonym: "inviable curved cell" EXACT [PomBase:mah] synonym: "inviable curved cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable curved vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0002451 ! inviable vegetative cell with abnormal cell shape intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000016 ! curved vegetative cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000016 ! curved vegetative cell relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2013-05-07T12:51:07Z [Term] id: FYPO:0002114 name: transporter activity phenotype def: "A phenotype that affects a transporter activity." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast transporter activity phenotype" EXACT [PomBase:mah] is_a: FYPO:0000652 ! molecular function phenotype intersection_of: FYPO:0000001 ! phenotype intersection_of: inheres_in GO:0005215 ! transporter activity relationship: inheres_in GO:0005215 ! transporter activity created_by: midori creation_date: 2013-05-07T13:25:10Z [Term] id: FYPO:0002115 name: normal transporter activity def: "A molecular function phenotype in which the observed rate of a specified transporter activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate is_a: FYPO:0000706 ! normal molecular function is_a: FYPO:0002114 ! transporter activity phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0005215 ! transporter activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0005215 ! transporter activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-05-07T13:26:31Z [Term] id: FYPO:0002116 name: abnormal transporter activity def: "A molecular function phenotype in which the observed rate of a specified transporter activity is abnormal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate is_a: FYPO:0000707 ! abnormal molecular function is_a: FYPO:0002114 ! transporter activity phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0005215 ! transporter activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0005215 ! transporter activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-05-07T13:27:14Z [Term] id: FYPO:0002117 name: abolished transporter activity def: "A molecular function phenotype in which a specified transporter activity is absent." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "catalytic activity abolished" EXACT [PomBase:mah] is_a: FYPO:0002116 ! abnormal transporter activity is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0005215 ! transporter activity relationship: towards GO:0005215 ! transporter activity created_by: midori creation_date: 2013-05-07T13:27:44Z [Term] id: FYPO:0002118 name: decreased transporter activity def: "A molecular function phenotype in which the observed rate of a specified transporter activity is decreased." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "reduced transporter activity" EXACT [PomBase:mah] is_a: FYPO:0002116 ! abnormal transporter activity is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0005215 ! transporter activity relationship: inheres_in GO:0005215 ! transporter activity created_by: midori creation_date: 2013-05-07T13:28:05Z [Term] id: FYPO:0002119 name: increased transporter activity def: "A molecular function phenotype in which the observed rate of a specified transporter activity is increased." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate is_a: FYPO:0002116 ! abnormal transporter activity is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0005215 ! transporter activity relationship: inheres_in GO:0005215 ! transporter activity created_by: midori creation_date: 2013-05-07T13:28:21Z [Term] id: FYPO:0002120 name: normal sodium:hydrogen antiporter activity def: "A molecular function phenotype in which the observed rate of sodium:hydrogen antiporter activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0002115 ! normal transporter activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0015385 ! sodium:proton antiporter activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0015385 ! sodium:proton antiporter activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-05-07T13:30:13Z [Term] id: FYPO:0002121 name: abnormal sodium:hydrogen antiporter activity def: "A molecular function phenotype in which the observed rate of sodium:hydrogen antiporter activity is abnormal." [PomBase:mah] is_a: FYPO:0002116 ! abnormal transporter activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0015385 ! sodium:proton antiporter activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0015385 ! sodium:proton antiporter activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-05-07T13:39:14Z [Term] id: FYPO:0002122 name: decreased sodium:hydrogen antiporter activity def: "A molecular function phenotype in which the observed rate of sodium:hydrogen antiporter activity is decreased." [PomBase:mah] synonym: "reduced sodium:hydrogen antiporter activity" EXACT [PomBase:mah] is_a: FYPO:0002118 ! decreased transporter activity is_a: FYPO:0002121 ! abnormal sodium:hydrogen antiporter activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0015385 ! sodium:proton antiporter activity relationship: inheres_in GO:0015385 ! sodium:proton antiporter activity created_by: midori creation_date: 2013-05-07T13:39:50Z [Term] id: FYPO:0002123 name: pyruvylated galactose absent from cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of 4,6-pyruvylated D-galactose (4,6-O-[(1R)-1-carboxyethylidene]-D-galactose) measured in a cell is too low to detect." [PomBase:mah] synonym: " 4,6-pyruvylated D-galactose absent from cell" EXACT [CHEBI:61747] synonym: "4,6-O-[(1R)-1-carboxyethylidene]-D-galactose absent from cell" EXACT [CHEBI:61747] synonym: "PvGal absent from cell" EXACT [PMID:25195688] synonym: "pyruvylated galactose absent from cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "pyruvylated galactose absent from cell during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001208 ! substance absent from cell during vegetative growth intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:61747 ! 4,6-O-[(1R)-1-carboxyethylidene]-D-galactose relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:61747 ! 4,6-O-[(1R)-1-carboxyethylidene]-D-galactose created_by: midori creation_date: 2013-05-07T15:16:42Z [Term] id: FYPO:0002125 name: abnormal protein localization to plasma membrane def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the plasma membrane is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found at the plasma membrane and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to plasma membrane" EXACT [PomBase:mah] synonym: "abnormal protein localization in plasma membrane" EXACT [GO:0072659] synonym: "abnormal protein localization to cell membrane" EXACT [GO:0005886, PomBase:mah] synonym: "abnormal protein localization to chromosome, centric region" EXACT [GO:0071459, PomBase:mah] synonym: "abnormal protein localization to plasma membrane during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein localization to plasma membrane during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000443 ! abnormal protein localization during vegetative growth is_a: FYPO:0000813 ! abnormal plasma membrane organization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0072659 ! protein localization to plasma membrane intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0072659 ! protein localization to plasma membrane relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-05-07T16:29:31Z [Term] id: FYPO:0002126 name: abolished protein localization to plasma membrane def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the plasma membrane is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to plasma membrane" EXACT [PomBase:mah] synonym: "abolished protein localization in plasma membrane" EXACT [GO:0072659] synonym: "abolished protein localization to cell membrane" EXACT [GO:0005886] synonym: "abolished protein localization to plasma membrane during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to plasma membrane during vegetative growth" EXACT [PomBase:mah] synonym: "protein localization to plasma membrane abolished" EXACT [PomBase:mah] is_a: FYPO:0001179 ! protein localization abolished during vegetative growth is_a: FYPO:0002125 ! abnormal protein localization to plasma membrane intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0072659 ! protein localization to plasma membrane relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0072659 ! protein localization to plasma membrane created_by: midori creation_date: 2013-05-07T16:32:01Z [Term] id: FYPO:0002127 name: increased protein localization to plasma membrane def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the plasma membrane is increased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to plasma membrane" EXACT [GO:0034504, PomBase:mah] synonym: "increased protein localization in plasma membrane" EXACT [GO:0072659] synonym: "increased protein localization to cell membrane" EXACT [GO:0005886] synonym: "increased protein localization to plasma membrane during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein localization to plasma membrane during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002125 ! abnormal protein localization to plasma membrane is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072659 ! protein localization to plasma membrane relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072659 ! protein localization to plasma membrane created_by: midori creation_date: 2013-05-07T16:32:58Z [Term] id: FYPO:0002128 name: abolished protein localization to plasma membrane, with protein mislocalized to cytoplasm def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the plasma membrane is abolished, and the protein is present in the cytoplasm instead." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to plasma membrane, with protein mislocalised to cytoplasm" EXACT [PomBase:mah] synonym: "abolished protein localization in plasma membrane, with protein mislocalized to cytoplasm" EXACT [GO:0072659] synonym: "abolished protein localization to cell membrane, with protein mislocalized to cytoplasm" EXACT [GO:0005886] synonym: "abolished protein localization to plasma membrane, with protein mislocalized to cytoplasm during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to plasma membrane, with protein mislocalized to cytoplasm, during vegetative growth" EXACT [PomBase:mah] synonym: "protein localization to plasma membrane abolished, with protein mislocalized to cytoplasm" EXACT [PomBase:mah] is_a: FYPO:0002126 ! abolished protein localization to plasma membrane intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000783 ! protein mislocalized to cytoplasm intersection_of: towards GO:0072659 ! protein localization to plasma membrane relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000783 ! protein mislocalized to cytoplasm relationship: towards GO:0072659 ! protein localization to plasma membrane created_by: midori creation_date: 2013-05-07T16:35:01Z [Term] id: FYPO:0002129 name: increased protein phosphorylation during cellular response to heat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a greater extent than normal during a cellular response to heat." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein phosphorylation during cellular response to heat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein phosphorylation during cellular response to heat during vegetative growth" EXACT [PomBase:mah] synonym: "increased protein phosphorylation during cellular response to heat shock" NARROW [PomBase:mah] is_a: FYPO:0001038 ! increased protein phosphorylation during vegetative growth intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0034605 ! cellular response to heat intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0034605 ! cellular response to heat relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2013-05-07T16:53:04Z [Term] id: FYPO:0002130 name: abolished protein phosphorylation during cellular response to heat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, does not occur during a cellular response to heat." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein phosphorylation during cellular response to heat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein phosphorylation during cellular response to heat during vegetative growth" EXACT [PomBase:mah] synonym: "abolished protein phosphorylation during cellular response to heat shock" NARROW [PomBase:mah] synonym: "protein phosphorylation abolished during cellular response to heat" EXACT [PomBase:mah] is_a: FYPO:0002033 ! abolished protein phosphorylation during vegetative growth intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0034605 ! cellular response to heat intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0006468 ! protein phosphorylation relationship: during GO:0034605 ! cellular response to heat relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2013-05-07T16:53:59Z [Term] id: FYPO:0002131 name: RNA binding phenotype def: "A phenotype that affects RNA binding. The relevant gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast DNA binding phenotype" EXACT [PomBase:mah] is_a: FYPO:0001092 ! binding phenotype intersection_of: FYPO:0000001 ! phenotype intersection_of: inheres_in GO:0003723 ! RNA binding relationship: inheres_in GO:0003723 ! RNA binding created_by: midori creation_date: 2013-05-07T16:56:35Z [Term] id: FYPO:0002132 name: abnormal RNA binding def: "A molecular function phenotype in which occurrence of RNA binding by a gene product is abnormal, when a gene or the bound RNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] is_a: FYPO:0000707 ! abnormal molecular function is_a: FYPO:0002131 ! RNA binding phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0003723 ! RNA binding intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0003723 ! RNA binding relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-05-07T16:56:52Z [Term] id: FYPO:0002133 name: abolished RNA binding def: "A molecular function phenotype in which RNA binding by a gene product does not occur, when a gene or the bound RNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "RNA binding abolished" EXACT [PomBase:mah] is_a: FYPO:0002132 ! abnormal RNA binding is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0003723 ! RNA binding relationship: towards GO:0003723 ! RNA binding created_by: midori creation_date: 2013-05-07T16:57:26Z [Term] id: FYPO:0002134 name: decreased RNA binding def: "A molecular function phenotype in which occurrence of RNA binding by a gene product is decreased, when a gene or the bound RNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "reduced RNA binding" EXACT [PomBase:mah] is_a: FYPO:0002132 ! abnormal RNA binding is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0003723 ! RNA binding relationship: inheres_in GO:0003723 ! RNA binding created_by: midori creation_date: 2013-05-07T16:57:49Z [Term] id: FYPO:0002135 name: increased RNA binding def: "A molecular function phenotype in which occurrence of RNA binding by a gene product is increased, when a gene or the bound RNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] is_a: FYPO:0002132 ! abnormal RNA binding is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0003723 ! RNA binding relationship: inheres_in GO:0003723 ! RNA binding created_by: midori creation_date: 2013-05-07T16:58:03Z [Term] id: FYPO:0002136 name: abnormal RNA catabolic process during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which an RNA catabolic process is abnormal." [GO:0006914, PomBase:mah] synonym: "abnormal RNA breakdown during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal RNA catabolic process during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal RNA catabolism during vegetative growth" EXACT [GO:0006401] synonym: "abnormal RNA degradation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000294 ! RNA metabolism phenotype is_a: FYPO:0001363 ! abnormal metabolic process during vegetative growth is_a: FYPO:0003551 ! abnormal RNA catabolic process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006401 ! RNA catabolic process intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006401 ! RNA catabolic process relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-05-07T17:08:20Z [Term] id: FYPO:0002137 name: decreased RNA catabolic process during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of an RNA catabolic process is decreased." [PomBase:mah] synonym: "decreased RNA breakdown during vegetative growth" EXACT [PomBase:mah] synonym: "decreased RNA catabolic process during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased RNA catabolism during vegetative growth" EXACT [GO:0006401] synonym: "decreased RNA degradation during vegetative growth" EXACT [PomBase:mah] synonym: "reduced RNA catabolic process during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002136 ! abnormal RNA catabolic process during vegetative growth is_a: FYPO:0003552 ! decreased RNA catabolic process intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006401 ! RNA catabolic process relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_output FYPO:0000825 ! increased RNA level during vegetative growth relationship: inheres_in GO:0006401 ! RNA catabolic process created_by: midori creation_date: 2013-05-07T17:09:04Z [Term] id: FYPO:0002138 name: increased RNA catabolic process during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of an RNA catabolic process is increased." [PomBase:mah] synonym: "increased RNA breakdown during vegetative growth" EXACT [PomBase:mah] synonym: "increased RNA catabolic process during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased RNA catabolism during vegetative growth" EXACT [GO:0006401] synonym: "increased RNA degradation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002136 ! abnormal RNA catabolic process during vegetative growth is_a: FYPO:0003553 ! increased RNA catabolic process intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006401 ! RNA catabolic process relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_output FYPO:0001117 ! decreased RNA level during vegetative growth relationship: inheres_in GO:0006401 ! RNA catabolic process created_by: midori creation_date: 2013-05-07T17:09:43Z [Term] id: FYPO:0002139 name: abolished protein threonine phosphorylation at Thr-Pro site def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of threonine residues N-terminal to proline residues (i.e. in Thr-Pro sequences) does not occur." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein threonine phosphorylation at threonine-proline site" EXACT [PomBase:mah] synonym: "abolished protein threonine phosphorylation at TP site" EXACT [PomBase:mah] is_a: FYPO:0002033 ! abolished protein phosphorylation during vegetative growth is_a: FYPO:0004425 ! abolished protein threonine phosphorylation created_by: midori creation_date: 2013-05-08T15:37:59Z [Term] id: FYPO:0002140 name: increased cellular pigment accumulation during cellular response to caffeine def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of cellular pigment accumulation is increased during a cellular response to caffeine." [PomBase:mah] comment: Note that normal cells do not accumulate detectable levels of any pigment; for this reason, FYPO does not include separate terms for 'increased' and 'abnormal' pigment accumulation. Also note that pigment accumulates in the vacuole. This term refers to GO:0033059 'cellular pigmentation', rather than GO:0043482 'cellular pigment accumulation', because GO:0043482 has paths to 'response to stimulus' in GO. synonym: "abnormal cellular pigment accumulation during cellular response to caffeine" EXACT [PomBase:mah] synonym: "altered colony color during cellular response to caffeine" RELATED [PomBase:al, PomBase:mah] synonym: "altered colony colour during cellular response to caffeine" RELATED [PomBase:al, PomBase:mah] synonym: "increased cellular pigment accumulation during cellular response to caffeine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular pigment accumulation during cellular response to caffeine during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000741 ! increased cellular pigment accumulation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0071313 ! cellular response to caffeine intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0033059 ! cellular pigmentation relationship: happens_during GO:0071313 ! cellular response to caffeine relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0033059 ! cellular pigmentation created_by: midori creation_date: 2013-05-08T15:43:11Z [Term] id: FYPO:0002141 name: normal cell population growth at low temperature def: "A cell population growth phenotype in which vegetative cells grow normally at a low temperature." [PomBase:mah] synonym: "normal growth at low temperature" BROAD [PomBase:mah] synonym: "normal vegetative cell population growth at low temperature" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0000047 ! normal cell population growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0001306 ! decreased temperature relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0001306 ! decreased temperature created_by: midori creation_date: 2013-05-08T15:54:16Z [Term] id: FYPO:0002142 name: altered cellular reactive oxygen species level def: "A cell phenotype in which the amount of reactive oxygen species (ROS) measured in a cell differs from normal." [PomBase:mah] synonym: "abnormal cellular reactive oxygen species level" EXACT [PomBase:mah] synonym: "abnormal cellular ROS accumulation" RELATED [PomBase:mah] synonym: "altered cellular ROS level" RELATED [PomBase:mah] is_a: FYPO:0000989 ! altered level of substance in cell intersection_of: PATO:0001159 ! concentrated intersection_of: inheres_in CL:0000000 ! cell intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:26523 ! reactive oxygen species relationship: inheres_in CL:0000000 ! cell relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:26523 ! reactive oxygen species created_by: midori creation_date: 2013-05-08T16:16:09Z [Term] id: FYPO:0002143 name: decreased cellular reactive oxygen species level in stationary phase def: "A cell phenotype in which the amount of reactive oxygen species (ROS) measured in a cell is lower than normal when the population in which the cell is found is in stationary phase." [PomBase:mah] synonym: "decreased cellular reactive oxygen species accumulation in stationary phase" RELATED [PomBase:mah] synonym: "decreased cellular ROS accumulation in stationary phase" RELATED [PomBase:mah] synonym: "decreased cellular ROS level in stationary phase" EXACT [PomBase:mah] synonym: "decreased ROS accumulation in stationary phase" RELATED [PomBase:al] synonym: "reduced cellular reactive oxygen species level in stationary phase" EXACT [PomBase:mah] synonym: "reduced cellular ROS level in stationary phase" EXACT [PomBase:mah] is_a: FYPO:0000991 ! decreased level of substance in cell is_a: FYPO:0002142 ! altered cellular reactive oxygen species level intersection_of: PATO:0001163 ! decreased concentration intersection_of: during GO:0060274 ! maintenance of stationary phase intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:26523 ! reactive oxygen species relationship: during GO:0060274 ! maintenance of stationary phase relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:26523 ! reactive oxygen species created_by: midori creation_date: 2013-05-08T16:20:07Z [Term] id: FYPO:0002144 name: increased protein threonine phosphorylation at Thr-Pro site def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of threonine residues N-terminal to proline residues (i.e. in Thr-Pro sequences) occurs to a greater extent than normal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein threonine phosphorylation at threonine-proline site" EXACT [PomBase:mah] synonym: "increased protein threonine phosphorylation at TP site" EXACT [PomBase:mah] is_a: FYPO:0001038 ! increased protein phosphorylation during vegetative growth created_by: midori creation_date: 2013-05-09T10:13:48Z [Term] id: FYPO:0002145 name: normal protein localization to nucleus during cellular response to DEM def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleus is normal (i.e. indistinguishable from wild type) during a cellular response to diethyl maleate (DEM), a compound which can induce oxidative stress." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to nucleus during cellular response to DEM" EXACT [PomBase:mah] synonym: "normal protein localization to nucleus during cellular response to DEM during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to nucleus during cellular response to DEM during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein localization to nucleus during cellular response to diethyl maleate" EXACT [PomBase:mah] is_a: FYPO:0001789 ! normal protein localization to nucleus during cellular response to oxidative stress intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: happens_during GO:1902112 ! cellular response to diethyl maleate intersection_of: inheres_in GO:0034504 ! protein localization to nucleus intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: happens_during GO:1902112 ! cellular response to diethyl maleate relationship: inheres_in GO:0034504 ! protein localization to nucleus relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-05-09T10:17:24Z [Term] id: FYPO:0002146 name: normal RNA level during cellular response to DEM def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to diethyl maleate (DEM) is normal (i.e. indistinguishable from wild type). Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [PomBase:mah] comment: We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "normal mRNA level during cellular response to DEM" NARROW [PomBase:mah] synonym: "normal RNA accumulation during cellular response to DEM" RELATED [PomBase:mah] synonym: "normal RNA level during cellular response to DEM during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal RNA level during cellular response to DEM during vegetative growth" EXACT [PomBase:mah] synonym: "normal RNA level during cellular response to diethyl maleate" EXACT [PomBase:mah] is_a: FYPO:0001317 ! normal RNA level during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: exists_during GO:1902112 ! cellular response to diethyl maleate intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: exists_during GO:1902112 ! cellular response to diethyl maleate relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2013-05-09T10:27:14Z [Term] id: FYPO:0002147 name: inviable vegetative cell population after spore germination def: "A cell population phenotype in which all vegetative cells arising from a population of germinated spores are inviable. The population may be mixed with respect to other phenotypes (e.g. whether cell division occurs)." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. synonym: "cell population inviable after spore germination" EXACT [PomBase:mah] synonym: "inviable germinated spore population" EXACT [PomBase:mah] synonym: "population of inviable germinated spores" EXACT [PomBase:vw] is_obsolete: true created_by: midori creation_date: 2013-05-10T13:02:05Z [Term] id: FYPO:0002148 name: inviable after spore germination, multiple cell divisions, abnormal morphology def: "A phenotype in which a spore germinates to produce a cell of abnormal morphology (i.e. size, shape, or structure) that undergoes two or more rounds of cell division, and then dies." [PomBase:al, PomBase:mah] synonym: "essential; germinating spore, multiple cell divisions, abnormal morphology" RELATED [PomBase:mah] synonym: "inviable following spore germination, multiple cell divisions, abnormal morphology" EXACT [PomBase:mah] synonym: "inviable germinated spore, multiple cell divisions, abnormal morphology" EXACT [PomBase:mah] is_a: FYPO:0002273 ! inviable vegetative cell with abnormal cell morphology is_a: FYPO:0002430 ! inviable after spore germination, multiple cell divisions created_by: midori creation_date: 2013-05-10T14:11:52Z [Term] id: FYPO:0002149 name: inviable elongated vegetative cell population def: "A cell population phenotype in which all cells in the population are inviable and longer than normal in the vegetative growth phase of the life cycle." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. is_obsolete: true replaced_by: FYPO:0002061 created_by: midori creation_date: 2013-05-10T14:18:17Z [Term] id: FYPO:0002150 name: inviable spore population def: "A cell population phenotype in which none of the cells in a population of spores are viable. Inviable spores do not germinate." [PomBase:mah] comment: Use this term only if no germination is observed in the entire population of mutant spores. An example of when this term is applicable is where a gene deletion in a diploid causes all null-mutant spores to fail to germinate, but the same gene deletion in vegetative cells is viable. To describe a mixed spore population in which some spores germinate and others do not, use the cell phenotype 'inviable spore' (FYPO:0002151; also consider related terms) with an extension to indicate penetrance. synonym: "inviable population of spores" EXACT [PomBase:vw] is_a: FYPO:0002059 ! inviable cell population created_by: midori creation_date: 2013-05-10T14:20:09Z [Term] id: FYPO:0002151 name: inviable spore alt_id: FYPO:0000306 def: "A viability phenotype in which a spore is unable to survive under conditions in which wild type spores survive. An inviable spore does not germinate." [PomBase:mah] synonym: "abolished spore germination" RELATED [PomBase:mah] synonym: "spore germination abolished" RELATED [PomBase:mah] is_a: FYPO:0000049 ! inviable cell intersection_of: PATO:0000718 ! lethal (sensu genetics) intersection_of: inheres_in CL:0000596 ! sexual spore intersection_of: towards GO:0009847 ! spore germination relationship: inheres_in CL:0000596 ! sexual spore relationship: towards GO:0009847 ! spore germination created_by: midori creation_date: 2013-05-10T14:22:34Z [Term] id: FYPO:0002152 name: inviable small vegetative cell population def: "A cell population phenotype in which all cells in the population are inviable and have a lower volume than normal in the vegetative growth phase of the life cycle." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. is_obsolete: true replaced_by: FYPO:0002061 created_by: midori creation_date: 2013-05-10T14:25:01Z [Term] id: FYPO:0002153 name: viable small vegetative cell population def: "A cell population phenotype in which all cells in the population are viable but have a lower volume than normal in the vegetative growth phase of the life cycle." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. synonym: "wee population" EXACT [PomBase:mah] is_obsolete: true replaced_by: FYPO:0002060 created_by: midori creation_date: 2013-05-10T14:26:01Z [Term] id: FYPO:0002154 name: abnormal septum site selection def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which barrier septum assembly takes place in an abnormal location. The site of septum assembly is normally determined by the location of the actomyosin contractile ring." [PomBase:mah] comment: Consider also annotating to 'abnormal contractile ring localization' (FYPO:0000033) because if the contractile ring forms in an abnormal location, the septum will also do so. The positions of both the contractile ring and the septum are determined by the processes that select the site of cell division. synonym: "abnormal barrier septum site selection" EXACT [PomBase:mah] synonym: "abnormal contractile ring localization resulting in abnormal septum site selection" RELATED [PomBase:mah] synonym: "abnormal contractile ring localization resulting in mislocalized septum" RELATED [PomBase:mah] synonym: "abnormal septum site selection during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal septum site selection during vegetative growth" EXACT [PomBase:mah] synonym: "septum site selection defects" EXACT [PomBase:mah] is_a: FYPO:0000117 ! abnormal septation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000918 ! barrier septum site selection intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_output FYPO:0000339 ! mislocalized septum during vegetative growth relationship: inheres_in_part_of GO:0000918 ! barrier septum site selection relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-05-10T15:13:11Z [Term] id: FYPO:0002155 name: normal telomere structure def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which chromosome structure is normal (i.e. indistinguishable from wild type) at the telomeric regions. Telomere structure refers to the position, shape, arrangement and connectivity of DNA and associated proteins in the telomeric region." [PomBase:mah] synonym: "normal chromosome structure at telomere" EXACT [PomBase:mah] synonym: "normal chromosome structure at telomeric region" EXACT [GO:0000781, PomBase:mah] synonym: "normal telomere structure during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal telomere structure during vegetative growth" EXACT [PomBase:mah] synonym: "normal telomeric region structure" EXACT [GO:0000781, PomBase:mah] is_a: FYPO:0001313 ! normal subcellular component during vegetative growth is_a: PATO:0000141 ! structure intersection_of: PATO:0000141 ! structure intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000781 ! chromosome, telomeric region intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000781 ! chromosome, telomeric region relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-05-10T15:34:01Z [Term] id: FYPO:0002156 name: binucleate monoseptate cell, with angled septum def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell has two nuclei and one septum, and in which the septum is located between the two nuclei but is not perpendicular to the long axis of the cell." [PomBase:mah] comment: Note that a cell that has the phenotype 'angled actomyosin contractile ring' (FYPO:0002027) will usually also subsequently display this phenotype. synonym: "binucleate monoseptate cell, with angled septum during mitotic cell cycle" RELATED [PomBase:mah] synonym: "binucleate monoseptate cell, with angled septum, during vegetative growth" EXACT [PomBase:mah] synonym: "binucleate monoseptate cell, with septum not orthogonal to long axis" RELATED [PomBase:mah] is_a: FYPO:0001222 ! binucleate vegetative cell is_a: FYPO:0001390 ! misoriented septum during vegetative growth created_by: midori creation_date: 2013-05-10T15:43:47Z [Term] id: FYPO:0002157 name: normal 1,3-beta-D-glucan synthase activity def: "A molecular function phenotype in which the observed rate of 1,3-beta-D-glucan synthase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0001086 ! normal glucosyltransferase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0003843 ! 1,3-beta-D-glucan synthase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0003843 ! 1,3-beta-D-glucan synthase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-05-10T16:01:38Z [Term] id: FYPO:0002158 name: abolished response to mitotic G2/M transition DNA damage checkpoint signaling def: "A cellular process phenotype in which a mitotic cell cycle arrest that normally occurs in response to G2/M transition DNA damage checkpoint signaling does not occur. Abolished arrest may result from a problem with detection of conditions that normally trigger a checkpoint, transduction of the checkpoint signal, or the response to the checkpoint signal." [PomBase:mah] comment: May indicate that a cell cycle checkpoint is not activated under conditions that normally trigger checkpoint signaling and subsequent cell cycle arrest. synonym: "abolished mitotic G2/M transition DNA damage checkpoint arrest" RELATED [PomBase:mah] synonym: "abolished response to mitotic G2 DNA damage checkpoint signaling" EXACT [GO:0072435] synonym: "cell cycle arrest resulting from mitotic G2/M transition DNA damage activation abolished" EXACT [GO:0072435] synonym: "response to mitotic G2/M transition DNA damage checkpoint signaling abolished" EXACT [PomBase:mah] is_a: FYPO:0002519 ! abolished response to mitotic G2/M transition checkpoint signaling intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0072435 ! response to mitotic G2 DNA damage checkpoint signaling relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0072435 ! response to mitotic G2 DNA damage checkpoint signaling created_by: midori creation_date: 2013-10-29T16:27:16Z [Term] id: FYPO:0002159 name: decreased 1,3-beta-D-glucan synthase activity def: "A molecular function phenotype in which the observed rate of 1,3-beta-D-glucan synthase activity is decreased." [PomBase:mah] synonym: "reduced 1,3-beta-D-glucan synthase activity" EXACT [PomBase:mah] is_a: FYPO:0001088 ! decreased glucosyltransferase activity is_a: FYPO:0001967 ! abnormal 1,3-beta-D-glucan synthase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0003843 ! 1,3-beta-D-glucan synthase activity relationship: inheres_in GO:0003843 ! 1,3-beta-D-glucan synthase activity created_by: midori creation_date: 2013-05-10T16:04:01Z [Term] id: FYPO:0002160 name: normal growth on cilofungin def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing cilofungin." [PomBase:mah] synonym: "normal cell population growth in presence of cilofungin" EXACT [PomBase:mah] synonym: "normal cell population growth on cilofungin" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to cilofungin" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on cilofungin" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:315019 ! cilofungin relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:315019 ! cilofungin created_by: midori creation_date: 2013-05-10T16:10:52Z [Term] id: FYPO:0002161 name: normal growth on Calcofluor White def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing Calcofluor White." [PomBase:mah] synonym: "normal cell population growth in presence of Calcofluor White" EXACT [PomBase:mah] synonym: "normal cell population growth on Calcofluor White" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to Calcofluor White" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on cilofungin" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:50011 ! Calcofluor White relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:50011 ! Calcofluor White created_by: midori creation_date: 2013-05-10T16:11:44Z [Term] id: FYPO:0002162 name: resistance to cilofungin def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of cilofungin than normal." [PomBase:mah] synonym: "resistance to cilofungin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to cilofungin during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to cilofungin" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:315019 ! cilofungin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:315019 ! cilofungin created_by: midori creation_date: 2013-05-10T16:15:33Z [Term] id: FYPO:0002163 name: decreased cell wall thickness during vegetative growth def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the fungal-type cell wall is thinner than normal." [PomBase:mah] synonym: "decreased cell wall thickness during mitotic cell cycle" RELATED [PomBase:mah] synonym: "reduced cell wall thickness during vegetative growth" EXACT [PomBase:mah] synonym: "thin cell wall during vegetative growth" EXACT [PomBase:al] is_a: FYPO:0000351 ! abnormal cell wall morphology during vegetative growth is_a: PATO:0000592 ! decreased thickness intersection_of: PATO:0000592 ! decreased thickness intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0009277 ! fungal-type cell wall relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0009277 ! fungal-type cell wall created_by: midori creation_date: 2013-05-10T16:26:35Z [Term] id: FYPO:0002164 name: mislocalized, curved actomyosin contractile ring def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell forms an actomyosin contractile ring in an abnormal location, and the ring has a curved, or C-shaped, profile. The normal location is at the midpoint of, and perpendicular to, the long axis of the cell." [PomBase:mah] comment: Note that the location of the contractile ring is determined by the location of the cell division site, so an abnormality in cell division site determination can be inferred from this phenotype. synonym: "actomyosin contractile ring displaced from midpoint and bent" RELATED [PomBase:vw] synonym: "actomyosin contractile ring displaced from midpoint and curved" EXACT [PomBase:vw] synonym: "contractile ring displaced from cell centre and curved" EXACT [PomBase:vw] synonym: "mislocalised, curved actomyosin contractile ring" EXACT [PomBase:mah] synonym: "mislocalized, curved actomyosin contractile ring during mitotic cell cycle" RELATED [PomBase:mah] synonym: "mislocalized, curved actomyosin contractile ring during vegetative growth" EXACT [PomBase:mah] synonym: "mislocalized, curved cytokinetic contractile ring" EXACT [PomBase:vw] synonym: "mislocalized, curved mitotic contractile ring" EXACT [PomBase:vw] is_a: FYPO:0002026 ! actomyosin contractile ring displaced from midpoint created_by: midori creation_date: 2013-05-10T16:32:44Z [Term] id: FYPO:0002165 name: abnormal polynucleotide 3'-phosphatase activity def: "A molecular function phenotype in which the observed rate of polynucleotide 3'-phosphatase activity is abnormal." [PomBase:mah] is_a: FYPO:0004302 ! abnormal phosphatase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0046403 ! polynucleotide 3'-phosphatase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0046403 ! polynucleotide 3'-phosphatase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-05-14T13:31:29Z [Term] id: FYPO:0002166 name: abolished polynucleotide 3'-phosphatase activity def: "A molecular function phenotype in which polynucleotide 3'-phosphatase activity is absent." [PomBase:mah] synonym: "polynucleotide 3'-phosphatase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0002165 ! abnormal polynucleotide 3'-phosphatase activity is_a: FYPO:0004303 ! abolished phosphatase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0046403 ! polynucleotide 3'-phosphatase activity relationship: towards GO:0046403 ! polynucleotide 3'-phosphatase activity created_by: midori creation_date: 2013-05-14T13:31:35Z [Term] id: FYPO:0002167 name: sensitive to ethyl methanesulfonate def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to ethyl methanesulfonate. Cells stop growing (and may die) at a concentration of ethyl methanesulfonate that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to ethyl methanesulfonate" EXACT [PomBase:mah] synonym: "sensitive to EMS" EXACT [PomBase:mah] synonym: "sensitive to ethyl methanesulfonate during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to ethyl methanesulfonate during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to ethyl methanesulphonate" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:23994 ! ethyl methanesulfonate relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:23994 ! ethyl methanesulfonate created_by: midori creation_date: 2013-05-14T13:34:52Z [Term] id: FYPO:0002168 name: normal growth on ethyl methanesulfonate def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing ethyl methanesulfonate." [PomBase:mah] synonym: "normal cell population growth in presence of ethyl methanesulfonate" EXACT [PomBase:mah] synonym: "normal cell population growth on EMS" EXACT [PomBase:mah] synonym: "normal cell population growth on ethyl methanesulfonate" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to ethyl methanesulfonate" RELATED [PomBase:al, PomBase:mah] synonym: "normal growth on ethyl methanesulphonate" EXACT [PomBase:mah] synonym: "normal vegetative cell population growth on ethyl methanesulfonate" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:23994 ! ethyl methanesulfonate relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:23994 ! ethyl methanesulfonate created_by: midori creation_date: 2013-05-14T13:37:06Z [Term] id: FYPO:0002169 name: normal growth during cellular response to gamma radiation def: "A cell growth phenotype in which cell population growth is normal (i.e. indistinguishable from wild type) during a cellular response to gamma radiation." [PomBase:mah] synonym: "normal cell population growth during cellular response to gamma irradiation" EXACT [PomBase:al] synonym: "normal cell population growth during cellular response to gamma radiation" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cell population growth in response to gamma irradiation" RELATED [PomBase:al] synonym: "normal cellular response to gamma radiation" RELATED [PomBase:mah] synonym: "normal sensitivity to gamma radiation" RELATED [PomBase:mah] synonym: "normal vegetative cell population growth during cellular response to gamma radiation" EXACT [PomBase:mah] is_a: FYPO:0004229 ! normal growth during cellular response to ionizing radiation intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: happens_during GO:0071480 ! cellular response to gamma radiation relationship: happens_during GO:0071480 ! cellular response to gamma radiation created_by: midori creation_date: 2013-05-14T13:52:38Z [Term] id: FYPO:0002170 name: inviable after spore germination, multiple cell divisions, branched, elongated cell def: "A phenotype in which a spore germinates to produce a cell that is elongated and branched (and septated), and undergoes two or more rounds of cell division and then dies." [PomBase:al, PomBase:mah] synonym: "essential; germinating spore, multiple cell divisions, branched, elongated cell" RELATED [PomBase:mah] synonym: "inviable after spore germination, multiple cell divisions, elongated and branched cell" EXACT [PomBase:al] synonym: "inviable following spore germination, multiple cell divisions, branched, elongated cell" EXACT [PomBase:mah] synonym: "inviable germinated spore, multiple cell divisions, branched, elongated cell" EXACT [PomBase:mah] is_a: FYPO:0002262 ! inviable after spore germination, multiple cell divisions, elongated cell created_by: midori creation_date: 2013-05-14T13:55:18Z [Term] id: FYPO:0002171 name: viable cell at low temperature def: "A viability phenotype observed in the vegetative growth phase of the life cycle in which a cell is able to survive at a low temperature." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "cell viable at low temperature" EXACT [PomBase:mah] synonym: "viable cell at low temperature during mitotic cell cycle" RELATED [PomBase:mah] synonym: "viable cell at low temperature during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001491 ! viable vegetative cell intersection_of: FYPO:0000124 ! viable cell intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0001306 ! decreased temperature relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0001306 ! decreased temperature created_by: midori creation_date: 2013-05-14T14:01:04Z [Term] id: FYPO:0002172 name: increased level of nitrogen starvation gene RNA during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more RNAs that are normally expressed during nitrogen starvation measured in a cell is higher than normal (i.e. higher than observed in wild-type cells during vegetative growth)." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "increased level of cellular response to nitrogen starvation gene RNA" EXACT [PomBase:al] synonym: "increased level of nitrogen depletion gene RNA during vegetative growth" EXACT [PomBase:vw] synonym: "increased level of nitrogen deprivation gene RNA during vegetative growth" EXACT [PomBase:vw] synonym: "increased level of nitrogen starvation gene RNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased level of nitrogen starvation gene transcripts during vegetative growth" EXACT [PomBase:vw] synonym: "increased nitrogen starvation gene RNA accumulation during vegetative growth" RELATED [PomBase:mah] is_a: FYPO:0000825 ! increased RNA level during vegetative growth created_by: midori creation_date: 2013-05-14T15:48:52Z [Term] id: FYPO:0002173 name: increased level of meiosis gene RNA during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more RNAs that are normally expressed during meiosis measured in a cell is higher than normal (i.e. higher than observed in wild-type cells during vegetative growth)." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "increased level of meiosis gene RNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased level of meiosis gene transcripts during vegetative growth" EXACT [PomBase:vw] synonym: "increased meiosis gene RNA accumulation during vegetative growth" RELATED [PomBase:mah] is_a: FYPO:0000825 ! increased RNA level during vegetative growth created_by: midori creation_date: 2013-05-14T15:52:47Z [Term] id: FYPO:0002174 name: decreased degradation of DSR-containing RNA def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of an RNA catabolic process that specifically degrades DSR-containing RNA molecules is decreased. A DSR (determinant of selective removal) is a region that is often found near the 3' end of meiosis-specific transcripts, usually contains one or more copies of the motif U(U/C/G)AAAC, and targets RNAs for degradation in vegetatively growing cells." [PMID:22046364, PMID:22645662, PomBase:mah] synonym: "decreased catabolism of DSR-containing RNA" EXACT [PomBase:mah] synonym: "decreased RNA catabolic process, DSR-containing RNA" EXACT [GO:0006401, PomBase:mah] synonym: "reduced degradation of DSR-containing RNA" EXACT [PomBase:mah] is_a: FYPO:0002137 ! decreased RNA catabolic process during vegetative growth created_by: midori creation_date: 2013-05-14T16:03:57Z [Term] id: FYPO:0002176 name: viable vegetative cell with normal cell size def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell has normal volume and dimensions and is viable." [PomBase:mah] synonym: "viable cell with normal cell size during vegetative growth" EXACT [PomBase:mah] synonym: "viable vegetative cell with normal cell size during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000124 ! viable cell is_a: FYPO:0001321 ! cellular physical quality phenotype during vegetative growth intersection_of: FYPO:0000124 ! viable cell intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0001124 ! normal vegetative cell size relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0001124 ! normal vegetative cell size created_by: midori creation_date: 2013-06-04T12:51:12Z [Term] id: FYPO:0002177 name: viable vegetative cell with normal cell morphology def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell has normal volume, dimensions and shape, and is viable." [PomBase:mah] synonym: "viable vegetative cell with normal cell shape and size" EXACT [PomBase:vw] is_a: FYPO:0001491 ! viable vegetative cell created_by: midori creation_date: 2013-06-04T12:52:23Z [Term] id: FYPO:0002178 name: viable mixed population including long cells def: "A mixed population phenotype in which cells in the population are viable, and some cells are longer than normal." [PomBase:jh, PomBase:mah] comment: This term was made obsolete because a "mixed population" observation would be better represented as two or more separate phenotype annotations, each with penetrance specified. synonym: "long low penetrance" RELATED [PomBase:jh, PomBase:vw] synonym: "non-essential; mixed population including long cells" RELATED [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-06-04T14:10:37Z [Term] id: FYPO:0002179 name: inviable mixed population, vegetative cells with abnormal morphology, including long cells def: "A mixed population phenotype in which a microcolony forms, all cells in the population are inviable and have abnormal morphology (i.e. size, shape, or structure), some cells may divide, and some cells are longer than normal." [PomBase:jh, PomBase:mah] comment: This term was made obsolete because a "mixed population" observation would be better represented as two or more separate phenotype annotations, each with penetrance specified. synonym: "essential; mixed population of vegetative cells with abnormal morphology, including long cells" RELATED [PomBase:mah] synonym: "inviable microcolony of vegetative cells with abnormal morphology, including long cells" EXACT [PomBase:mah, PomBase:vw] is_obsolete: true created_by: midori creation_date: 2013-06-04T15:30:24Z [Term] id: FYPO:0002180 name: viable mixed vegetative cell population including cell with normal morphology and long cells def: "A mixed population phenotype in which cells in the population are viable, some cells are longer than normal, and the rest of the cells are of normal morphology (i.e. size, shape, and structure)." [PomBase:jh, PomBase:mah] comment: This term was made obsolete because a "mixed population" observation would be better represented as two or more separate phenotype annotations, each with penetrance specified. synonym: "long low penetrance" RELATED [PomBase:jh, PomBase:vw] is_obsolete: true created_by: midori creation_date: 2013-06-04T15:36:23Z [Term] id: FYPO:0002181 name: inviable mixed population including germinated spores and spheroid cells def: "A mixed population phenotype in which all cells in a population are inviable, and the population includes a mixture of germinated spores and spheroid vegetative cells. The spheroid cells arise from division of some of the germinated spores, and may form a microcolony of up to 64 cells." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because a "mixed population" observation would be better represented as two or more separate phenotype annotations, each with penetrance specified. synonym: "essential; mixed population including germinated spores and spheroid cells" RELATED [PomBase:mah] synonym: "inviable mixed population including germinated spores and rounded cells" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-06-04T15:53:26Z [Term] id: FYPO:0002182 name: inviable mixed population including spores, germinated spores and spheroid cells def: "A mixed population phenotype in which all cells in a population are inviable, and the population includes a mixture of ungerminated spores, germinated spores and spheroid vegetative cells. The spheroid cells arise from division of some of the germinated spores, and may form a microcolony of up to 64 cells." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because a "mixed population" observation would be better represented as two or more separate phenotype annotations, each with penetrance specified. synonym: "essential; mixed population including spores, germinated spores and spheroid cells" RELATED [PomBase:mah] synonym: "inviable mixed population including spores, germinated spores and rounded cells" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-06-04T16:11:59Z [Term] id: FYPO:0002183 name: inviable mixed population including spores, germinated spores and cells with normal morphology def: "A mixed population phenotype in which all cells in a population are inviable, and the population includes a mixture of ungerminated spores, germinated spores and cells with normal morphology (i.e. size, shape, and structure). The cells with normal morphology arise from division of some of the germinated spores, and may form a microcolony of up to 64 cells." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because a "mixed population" observation would be better represented as two or more separate phenotype annotations, each with penetrance specified. synonym: "essential; mixed population including spores, germinated spores and cells with normal morphology" RELATED [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-06-04T16:13:03Z [Term] id: FYPO:0002184 name: inviable mixed population including spores, germinated spores and tapered cells def: "A mixed population phenotype in which all cells in a population are inviable, and the population includes a mixture of ungerminated spores, germinated spores and tapered vegetative cells. The tapered cells arise from division of some of the germinated spores, and may form a microcolony of up to 64 cells." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because a "mixed population" observation would be better represented as two or more separate phenotype annotations, each with penetrance specified. synonym: "essential; mixed population including spores, germinated spores and tapered cells" RELATED [PomBase:mah] synonym: "inviable mixed population including spores, germinated spores and bottle/skittle cells" EXACT [PomBase:mah] synonym: "inviable mixed population including spores, germinated spores and skittle-shaped cells" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-06-04T16:20:17Z [Term] id: FYPO:0002185 name: inviable mixed population including germinated spores and tapered cells def: "A mixed population phenotype in which all cells in a population are inviable, and the population includes a mixture of germinated spores and tapered vegetative cells. The tapered cells arise from division of some of the germinated spores, and may form a microcolony of up to 64 cells." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because a "mixed population" observation would be better represented as two or more separate phenotype annotations, each with penetrance specified. synonym: "essential; mixed population including germinated spores and tapered cells" RELATED [PomBase:mah] synonym: "inviable mixed population including germinated spores and bottle/skittle cells" RELATED [PomBase:mah] synonym: "inviable mixed population including germinated spores and skittle-shaped cells" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-06-04T16:22:21Z [Term] id: FYPO:0002186 name: inviable microcolony, small cells def: "A cell population phenotype in which a cell undergoes one or a few rounds of cell division before cells die, resulting in the formation a colony that contains only a few inviable cells that have a lower volume than normal. Up to 6 rounds of cell division (generating 64 cells) may be observed, but 3 divisions or fewer is more typical." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype, with penetrance extensions where needed. synonym: "inviable microcolony, small vegetative cells" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-06-04T16:42:49Z [Term] id: FYPO:0002187 name: inviable normal volume spheroid vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is inviable, is shaped in the form of a spheroid, and has a normal volume." [PomBase:mah] synonym: "essential; normal volume spheroid vegetative cell" RELATED [PomBase:mah] synonym: "inviable normal volume rounded vegetative cell" EXACT [PomBase:mah] synonym: "inviable normal volume spheroid cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable normal volume spheroid vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000946 ! normal volume spheroid vegetative cell is_a: FYPO:0001511 ! inviable vegetative cell, abnormal cell shape, normal cell size is_a: FYPO:0002482 ! inviable spheroid vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000021 ! spheroid vegetative cell intersection_of: has_part FYPO:0000926 ! normal volume vegetative cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000021 ! spheroid vegetative cell relationship: has_part FYPO:0000926 ! normal volume vegetative cell relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2013-06-04T17:02:22Z [Term] id: FYPO:0002188 name: inviable microcolony, normal volume spheroid cells def: "A cell population phenotype in which a cell undergoes one or a few rounds of cell division before cells die, resulting in the formation a colony that contains only a few inviable cells that have a normal volume and spheroid shape. Up to 6 rounds of cell division (generating 64 cells) may be observed, but 3 divisions or fewer is more typical." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype, with penetrance extensions where needed. synonym: "inviable microcolony, normal volume rounded cells" EXACT [PomBase:mah] synonym: "inviable microcolony, normal volume spheroid vegetative cells" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-06-04T17:03:55Z [Term] id: FYPO:0002189 name: viable normal volume spheroid vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is viable, is shaped in the form of a spheroid, and has a normal volume." [PomBase:mah] synonym: "viable normal volume rounded vegetative cell" EXACT [PomBase:mah] synonym: "viable normal volume spheroid cell during vegetative growth" EXACT [PomBase:mah] synonym: "viable normal volume spheroid vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000946 ! normal volume spheroid vegetative cell is_a: FYPO:0001510 ! viable vegetative cell, abnormal cell shape, normal cell size is_a: FYPO:0002380 ! viable spheroid vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000021 ! spheroid vegetative cell intersection_of: has_part FYPO:0000926 ! normal volume vegetative cell intersection_of: has_part FYPO:0001491 ! viable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000021 ! spheroid vegetative cell relationship: has_part FYPO:0000926 ! normal volume vegetative cell relationship: has_part FYPO:0001491 ! viable vegetative cell created_by: midori creation_date: 2013-06-04T17:06:17Z [Term] id: FYPO:0002190 name: inviable swollen spheroid vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is inviable, is shaped in the form of a spheroid, and has a larger volume than normal. In a swollen cell, both length and diameter are greater than normal, although the cell is only considered elongated if the length:width ratio is also greater than normal." [PomBase:mah] synonym: "essential; swollen spheroid vegetative cell" RELATED [PomBase:mah] synonym: "inviable enlarged spheroid vegetative cell" RELATED [PomBase:mah] synonym: "inviable enlarged volume spheroid vegetative cell" EXACT [PomBase:mah] synonym: "inviable large spheroid vegetative cell" RELATED [PomBase:vw] synonym: "inviable swollen rounded vegetative cell" EXACT [PomBase:mah] synonym: "inviable swollen spheroid cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable swollen spheroid vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable, increased spheroid vegetative cell size" RELATED [PomBase:vw] synonym: "inviable, increased spheroid vegetative cell volume" EXACT [PomBase:mah] is_a: FYPO:0000945 ! swollen spheroid vegetative cell is_a: FYPO:0002415 ! inviable swollen vegetative cell with abnormal cell shape is_a: FYPO:0002482 ! inviable spheroid vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000021 ! spheroid vegetative cell intersection_of: has_part FYPO:0000025 ! swollen cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000021 ! spheroid vegetative cell relationship: has_part FYPO:0000025 ! swollen cell relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2013-06-04T17:07:57Z [Term] id: FYPO:0002191 name: inviable swollen septated spheroid vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is inviable, is shaped in the form of a spheroid, has one or more septa, and has a larger volume than normal. In a swollen cell, both length and diameter are greater than normal, although the cell is only considered elongated if the length:width ratio is also greater than normal." [PomBase:mah] synonym: "essential; swollen septated spheroid vegetative cell" RELATED [PomBase:mah] synonym: "inviable enlarged septated spheroid vegetative cell" RELATED [PomBase:mah] synonym: "inviable enlarged volume septated spheroid vegetative cell" EXACT [PomBase:mah] synonym: "inviable septated large spheroid vegetative cell" RELATED [PomBase:vw] synonym: "inviable swollen septated rounded vegetative cell" EXACT [PomBase:mah] synonym: "inviable swollen septated spheroid cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable swollen septated spheroid vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable, septated, increased spheroid vegetative cell size" RELATED [PomBase:vw] synonym: "inviable, septated, increased spheroid vegetative cell volume" EXACT [PomBase:mah] is_a: FYPO:0002190 ! inviable swollen spheroid vegetative cell is_a: FYPO:0002240 ! swollen septated spheroid vegetative cell is_a: FYPO:0002452 ! inviable septated vegetative cell with abnormal cell morphology intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000021 ! spheroid vegetative cell intersection_of: has_part FYPO:0000025 ! swollen cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0002342 ! septated vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000021 ! spheroid vegetative cell relationship: has_part FYPO:0000025 ! swollen cell relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0002342 ! septated vegetative cell created_by: midori creation_date: 2013-06-04T17:09:31Z [Term] id: FYPO:0002192 name: inviable microcolony, normal volume septated spheroid cells def: "A cell population phenotype in which a cell undergoes one or a few rounds of cell division before cells die, resulting in the formation a colony that contains only a few inviable cells that have a normal volume and spheroid shape, and contain one or more septa each. Up to 6 rounds of cell division (generating 64 cells) may be observed, but 3 divisions or fewer is more typical." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype, with penetrance extensions where needed. synonym: "inviable microcolony, normal volume septated rounded cells" EXACT [PomBase:mah] synonym: "inviable microcolony, normal volume septated spheroid vegetative cells" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-06-04T17:27:04Z [Term] id: FYPO:0002193 name: inviable normal volume septated spheroid vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is inviable, contains one or more septa, is shaped in the form of a spheroid, and has a normal volume." [PomBase:mah] synonym: "inviable normal volume septated rounded vegetative cell" RELATED [PomBase:mah] synonym: "inviable normal volume septated spheroid cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable normal volume septated spheroid vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001511 ! inviable vegetative cell, abnormal cell shape, normal cell size intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000926 ! normal volume vegetative cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0001955 ! spheroid cell intersection_of: has_part FYPO:0002342 ! septated vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000926 ! normal volume vegetative cell relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0001955 ! spheroid cell relationship: has_part FYPO:0002342 ! septated vegetative cell created_by: midori creation_date: 2013-06-04T17:28:33Z [Term] id: FYPO:0002194 name: inviable microcolony, swollen septated spheroid cells def: "A cell population phenotype in which a cell undergoes one or a few rounds of cell division before cells die, resulting in the formation a colony that contains only a few inviable cells that have a larger volume than normal and spheroid shape, and contain one or more septa each. Up to 6 rounds of cell division (generating 64 cells) may be observed, but 3 divisions or fewer is more typical." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype, with penetrance extensions where needed. synonym: "inviable microcolony, enlarged septated spheroid vegetative cells" RELATED [PomBase:mah] synonym: "inviable microcolony, septated large spheroid vegetative cells" RELATED [PomBase:vw] synonym: "inviable microcolony, septated, spheroid vegetative cells with increased cell size" RELATED [PomBase:vw] synonym: "inviable microcolony, septated, spheroid vegetative cells with increased cell volume" EXACT [PomBase:mah] synonym: "inviable microcolony, swollen septated rounded cells" EXACT [PomBase:mah] synonym: "inviable microcolony, swollen septated spheroid vegetative cells" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-06-04T17:31:20Z [Term] id: FYPO:0002195 name: normal morphology viable vegetative cell population def: "A cell population phenotype in which all cells in the population are viable and have normal morphology (i.e. size, shape, and structure) in the vegetative growth phase of the life cycle." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. synonym: "viable vegetative cell population with normal cell morphology" EXACT [PomBase:mah] synonym: "viable vegetative cell population with normal cell shape and size" EXACT [PomBase:vw] is_obsolete: true replaced_by: FYPO:0002060 created_by: midori creation_date: 2013-06-05T10:45:58Z [Term] id: FYPO:0002196 name: abnormal vegetative cell shape def: "A cell phenotype in which cell shape is altered in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "abnormal cell shape during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal vegetative cell shape during mitotic cell cycle" RELATED [PomBase:mah] synonym: "misshapen vegetative cell" RELATED [PomBase:mah] is_a: FYPO:0001118 ! abnormal vegetative cell morphology is_a: FYPO:0001126 ! abnormal cell shape intersection_of: FYPO:0001126 ! abnormal cell shape intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase created_by: midori creation_date: 2013-06-05T11:05:19Z [Term] id: FYPO:0002197 name: viable vegetative cell with abnormal cell shape def: "A cell phenotype in which a cell is viable, and cell shape is altered in the vegetative growth phase of the life cycle." [PomBase:mah, PomBase:vw] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "viable lumpy cell" RELATED [PomBase:vw] synonym: "viable vegetative cell with abnormal cell shape during mitotic cell cycle" RELATED [PomBase:mah] synonym: "viable, abnormal cell shape during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0001126 ! abnormal cell shape intersection_of: has_part FYPO:0001491 ! viable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0001126 ! abnormal cell shape relationship: has_part FYPO:0001491 ! viable vegetative cell created_by: midori creation_date: 2013-06-05T11:09:19Z [Term] id: FYPO:0002198 name: viable vegetative cell population with abnormal cell shape def: "A cell population phenotype in which all cells in the population are viable but have abnormal cell shape, in the vegetative growth phase of the life cycle." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. synonym: "viable, abnormally shaped vegetative cell population" EXACT [PomBase:mah] is_obsolete: true replaced_by: FYPO:0002060 created_by: midori creation_date: 2013-06-05T11:33:07Z [Term] id: FYPO:0002199 name: inviable vegetative cell with normal cell morphology def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell has a normal morphology (i.e. size, shape, and structure) but is inviable." [PomBase:mah] synonym: "inviable cell with normal cell morphology during vegetative growth" EXACT [PomBase:mah] synonym: "inviable vegetative cell with normal cell morphology during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable vegetative cell with normal cell shape and size" EXACT [PomBase:vw] is_a: FYPO:0001489 ! inviable vegetative cell intersection_of: FYPO:0000049 ! inviable cell intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0001315 ! normal vegetative cell morphology relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0001315 ! normal vegetative cell morphology created_by: midori creation_date: 2013-06-05T11:37:33Z [Term] id: FYPO:0002200 name: inviable stubby septated vegetative cell def: "A cell morphology phenotype in which a vegetatively growing cell is inviable and has one or more septa, and the cell diameter is larger than normal and the cell length is shorter than normal." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "essential; stubby septated vegetative cell" RELATED [PomBase:mah] synonym: "inviable stubby septated cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable stubby septated vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable watermelon-shaped septated vegetative cell" EXACT [PomBase:mah] synonym: "stubby septated inviable vegetative cell" EXACT [PomBase:mah] is_a: FYPO:0002107 ! inviable stubby vegetative cell is_a: FYPO:0002452 ! inviable septated vegetative cell with abnormal cell morphology intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000024 ! stubby cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0002342 ! septated vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000024 ! stubby cell relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0002342 ! septated vegetative cell created_by: midori creation_date: 2013-06-05T13:23:12Z [Term] id: FYPO:0002201 name: viable stubby vegetative cell population def: "A cell population phenotype in which all cells in the population are viable but the cell diameter is larger than normal and the cell length is shorter than normal, in the vegetative growth phase of the life cycle." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. synonym: "stubby viable vegetative cell population" EXACT [PomBase:mah] is_obsolete: true replaced_by: FYPO:0002060 created_by: midori creation_date: 2013-06-05T13:25:46Z [Term] id: FYPO:0002202 name: inviable stubby vegetative cell population def: "A cell population phenotype in which all cells in the population are inviable and the cell diameter is larger than normal and the cell length is shorter than normal, in the vegetative growth phase of the life cycle." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. synonym: "stubby inviable vegetative cell population" EXACT [PomBase:mah] is_obsolete: true replaced_by: FYPO:0002061 created_by: midori creation_date: 2013-06-05T13:27:13Z [Term] id: FYPO:0002203 name: inviable microcolony, stubby cells def: "A cell population phenotype in which a cell undergoes one or a few rounds of cell division before cells die, resulting in the formation a colony that contains only a few inviable cells in which the cell diameter is larger than normal and the cell length is shorter than normal. Up to 6 rounds of cell division (generating 64 cells) may be observed, but 3 divisions or fewer is more typical." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype, with penetrance extensions where needed. synonym: "inviable microcolony, stubby vegetative cells" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-06-05T13:34:24Z [Term] id: FYPO:0002204 name: inviable microcolony, stubby septated cells def: "A cell population phenotype in which a cell undergoes one or a few rounds of cell division before cells die, resulting in the formation a colony that contains only a few inviable cells that each contain one or more septa, and in which the cell diameter is larger than normal and the cell length is shorter than normal. Up to 6 rounds of cell division (generating 64 cells) may be observed, but 3 divisions or fewer is more typical." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype, with penetrance extensions where needed. synonym: "inviable microcolony, stubby septated vegetative cells" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-06-05T13:36:02Z [Term] id: FYPO:0002206 name: inviable swollen spore population def: "A cell population phenotype in which none of the cells in a population of spores are viable, and all have a larger volume than normal. In a swollen cell, both length and diameter are greater than normal, although the cell is only considered elongated if the length:width ratio is also greater than normal. Inviable spores do not germinate." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. synonym: "inviable enlarged spore population" RELATED [PomBase:mah] synonym: "inviable large spore population" RELATED [PomBase:vw] synonym: "inviable population of swollen spores" EXACT [PomBase:vw] synonym: "inviable spore population with increased cell size" RELATED [PomBase:vw] synonym: "inviable spore population with increased cell volume" EXACT [PomBase:mah] is_obsolete: true replaced_by: FYPO:0002150 created_by: midori creation_date: 2013-06-05T13:51:00Z [Term] id: FYPO:0002207 name: inviable swollen spore alt_id: FYPO:0000308 def: "A viability phenotype in which a spore is unable to survive under conditions in which wild type spores survive, and has a larger volume than normal. In a swollen cell, both length and diameter are greater than normal, although the cell is only considered elongated if the length:width ratio is also greater than normal. An inviable spore does not germinate." [PomBase:mah] synonym: "inviable enlarged spore" RELATED [PomBase:mah] synonym: "inviable large spore" RELATED [PomBase:vw] synonym: "inviable spore with increased spore size" RELATED [PomBase:vw] synonym: "inviable spore with increased spore volume" EXACT [PomBase:mah] synonym: "spore germination abolished, enlarged spore" RELATED [PomBase:mah] synonym: "spore germination abolished, increased spore size" RELATED [PomBase:vw] synonym: "spore germination abolished, increased spore volume" RELATED [PomBase:mah] synonym: "spore germination abolished, large spore" RELATED [PomBase:vw] synonym: "spore germination abolished, swollen spore" RELATED [PomBase:mah] is_a: FYPO:0000309 ! inviable spore with abnormal morphology intersection_of: FYPO:0000002 ! cell phenotype intersection_of: has_part FYPO:0000347 ! swollen spore intersection_of: has_part FYPO:0002151 ! inviable spore relationship: has_part FYPO:0000347 ! swollen spore relationship: has_part FYPO:0002151 ! inviable spore created_by: midori creation_date: 2013-06-05T13:52:59Z [Term] id: FYPO:0002208 name: inviable swollen spore with abnormal shape alt_id: FYPO:0002205 def: "A viability phenotype in which a spore is unable to survive under conditions in which wild type spores survive, and has a larger volume than normal and an abnormal shape. An inviable spore does not germinate." [PomBase:mah] synonym: "inviable enlarged spore with abnormal shape" RELATED [PomBase:mah] synonym: "inviable large spore with abnormal shape" RELATED [PomBase:vw] synonym: "inviable spore with increased size and abnormal shape" RELATED [PomBase:vw] synonym: "inviable spore with increased spore size and abnormal shape" RELATED [PomBase:vw] synonym: "inviable spore with increased spore volume and abnormal shape" EXACT [PomBase:mah] synonym: "inviable spore with increased volume and abnormal shape" EXACT [PomBase:mah] synonym: "inviable swollen abnormally shaped spore" EXACT [PomBase:mah] synonym: "inviable swollen misshapen spore" RELATED [PomBase:mah] synonym: "spore germination abolished, enlarged spore with abnormal shape" RELATED [PomBase:mah] synonym: "spore germination abolished, large spore with abnormal shape" RELATED [PomBase:vw] synonym: "spore germination abolished, spore with abnormal shape and increased cell size" RELATED [PomBase:vw] synonym: "spore germination abolished, spore with abnormal shape and increased cell volume" EXACT [PomBase:mah] synonym: "spore germination abolished, swollen misshapen spores" RELATED [PomBase:mah] synonym: "spore germination abolished, swollen spore with abnormal shape" RELATED [PomBase:mah] is_a: FYPO:0002207 ! inviable swollen spore is_a: FYPO:0002427 ! inviable spore with abnormal shape intersection_of: FYPO:0000002 ! cell phenotype intersection_of: has_part FYPO:0000347 ! swollen spore intersection_of: has_part FYPO:0001126 ! abnormal cell shape intersection_of: has_part FYPO:0002151 ! inviable spore relationship: has_part FYPO:0000347 ! swollen spore relationship: has_part FYPO:0001126 ! abnormal cell shape relationship: has_part FYPO:0002151 ! inviable spore created_by: midori creation_date: 2013-06-05T13:58:55Z [Term] id: FYPO:0002209 name: inviable swollen spore population with abnormal spore shape def: "A cell population phenotype in which none of the cells in a population of spores are viable, and all have a larger volume than normal and an abnormal shape. Inviable spores do not germinate." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. synonym: "inviable enlarged spore population with abnormal spore shape" RELATED [PomBase:mah] synonym: "inviable large spore population with abnormal spore shape" RELATED [PomBase:vw] synonym: "inviable population of swollen spores with abnormal shape" EXACT [PomBase:vw] synonym: "inviable spore population with increased cell size and abnormal spore shape" RELATED [PomBase:vw] synonym: "inviable spore population with increased cell volume and abnormal spore shape" EXACT [PomBase:mah] synonym: "inviable swollen spore population with abnormal shape" EXACT [PomBase:mah] is_obsolete: true replaced_by: FYPO:0002150 created_by: midori creation_date: 2013-06-05T13:59:40Z [Term] id: FYPO:0002210 name: inviable microcolony, tapered cells def: "A cell population phenotype in which a cell undergoes one or a few rounds of cell division before cells die, resulting in the formation a colony that contains only a few inviable cells that taper at one end to a diameter smaller than the other. Up to 6 rounds of cell division (generating 64 cells) may be observed, but 3 divisions or fewer is more typical." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype, with penetrance extensions where needed. synonym: "inviable microcolony, bottle/skittle cells" EXACT [PomBase:mah] synonym: "inviable microcolony, skittle-shaped cells" EXACT [PomBase:mah] synonym: "inviable microcolony, tapered vegetative cells" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-06-05T14:18:25Z [Term] id: FYPO:0002211 name: inviable vegetative cell population after spore germination, elongated germ tubes def: "A cell population phenotype in which all vegetative cells arising from a population of germinated spores are inviable, and the germinated spores have elongated germ tubes. The population may be mixed with respect to other phenotypes (e.g. whether cell division occurs)." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. synonym: "cell population inviable after spore germination, with elongated germ tubes" EXACT [PomBase:mah] synonym: "inviable germinated spore population, elongated germ tubes" EXACT [PomBase:mah] is_obsolete: true replaced_by: FYPO:0002061 created_by: midori creation_date: 2013-06-05T14:44:53Z [Term] id: FYPO:0002212 name: inviable after spore germination, without cell division, with elongated, curved germ tube def: "A phenotype in which a spore germinates to produce an elongated germ tube that is curved along the long axis, but does not go on to form a viable dividing cell." [PomBase:mah] synonym: "essential; germinating spore with elongated, curved germ tube" RELATED [PomBase:mah] synonym: "inviable after spore germination, without cell division, elongated, curved cell" EXACT [PomBase:mah] synonym: "inviable following spore germination with elongated, curved germ tube" EXACT [PomBase:mah] synonym: "inviable germinated spore, without cell division, with elongated, curved germ tube" EXACT [PomBase:mah] is_a: FYPO:0002379 ! inviable after spore germination, without cell division, with elongated germ tube is_a: FYPO:0002411 ! inviable curved elongated vegetative cell created_by: midori creation_date: 2013-06-05T14:47:02Z [Term] id: FYPO:0002213 name: inviable vegetative cell population after spore germination, elongated curved germ tubes def: "A cell population phenotype in which all vegetative cells arising from a population of germinated spores are inviable, and the germinated spores have elongated germ tubes that are curved along the long axis. The population may be mixed with respect to other phenotypes (e.g. whether cell division occurs)." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. synonym: "cell population inviable after spore germination, with elongated, curved germ tubes" EXACT [PomBase:mah] synonym: "inviable germinated spore population, elongated curved germ tubes" EXACT [PomBase:mah] is_obsolete: true replaced_by: FYPO:0002061 created_by: midori creation_date: 2013-06-05T14:48:45Z [Term] id: FYPO:0002214 name: inviable vegetative cell population after spore germination, abnormal germ tube morphology def: "A cell population phenotype in which all vegetative cells arising from a population of germinated spores are inviable, and have germ tubes with abnormal morphology (i.e. size, shape, or structure)." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. synonym: "cell population inviable after spore germination, abnormal germ tube morphology" EXACT [PomBase:mah] synonym: "inviable germinated spore population, abnormal germ tube morphology" EXACT [PomBase:mah] synonym: "inviable population of undivided germinated spores with abnormal germ tube morphology" EXACT [PomBase:vw] is_obsolete: true replaced_by: FYPO:0002061 created_by: midori creation_date: 2013-06-05T14:55:56Z [Term] id: FYPO:0002215 name: viable curved elongated vegetative cell def: "A cell morphology phenotype in which a vegetatively growing cell is viable, is longer than normal, and is curved along the long axis. In a curved cell, the long axis follows a smooth bend rather than a straight line." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "curved elongated viable cell" EXACT [PomBase:mah] synonym: "viable curved elongated cell" EXACT [PomBase:mah] synonym: "viable curved elongated cell during vegetative growth" EXACT [PomBase:mah] synonym: "viable curved elongated vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001492 ! viable elongated vegetative cell is_a: FYPO:0002112 ! viable curved vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000016 ! curved vegetative cell intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0001491 ! viable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000016 ! curved vegetative cell relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0001491 ! viable vegetative cell created_by: midori creation_date: 2013-06-05T15:02:02Z [Term] id: FYPO:0002216 name: viable curved vegetative cell population def: "A cell population phenotype in which all cells in the population are viable and are curved along the long axis in the vegetative growth phase of the life cycle." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. synonym: "population of curved viable cells" EXACT [PomBase:vw] is_obsolete: true replaced_by: FYPO:0002060 created_by: midori creation_date: 2013-06-05T15:06:28Z [Term] id: FYPO:0002217 name: viable curved elongated vegetative cell population def: "A cell population phenotype in which all cells in the population are viable, longer than normal, and curved along the long axis in the vegetative growth phase of the life cycle." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. synonym: "population of curved viable long cells" EXACT [PomBase:vw] synonym: "viable curved long vegetative cell population" EXACT [PomBase:mah] is_obsolete: true replaced_by: FYPO:0002060 created_by: midori creation_date: 2013-06-05T15:07:23Z [Term] id: FYPO:0002218 name: inviable vegetative cell population after spore germination, normal unseptated germ tube morphology def: "A cell population phenotype in which all vegetative cells arising from a population of germinated spores are inviable, and have germ tubes with normal morphology (i.e. size, shape, and structure) that do not septate." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. synonym: "inviable germinated spore population, normal unseptated germ tube morphology" EXACT [PomBase:mah] is_obsolete: true replaced_by: FYPO:0002061 created_by: midori creation_date: 2013-06-05T15:16:34Z [Term] id: FYPO:0002219 name: normal chromosome disjunction at meiosis I def: "A cellular process phenotype in which homologous chromosome segregation, or disjunction, is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal homologous chromosome segregation" EXACT [GO:0045143] is_a: FYPO:0003176 ! normal meiotic chromosome segregation intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0045143 ! homologous chromosome segregation intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0045143 ! homologous chromosome segregation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-06-05T16:23:45Z [Term] id: FYPO:0002220 name: increased duration of meiotic cell cycle phase def: "A cellular process phenotype in which the duration of one or more meiotic cell cycle phases is longer than normal." [PomBase:mah] synonym: "prolonged meiotic cell cycle phase" EXACT [PomBase:mah] is_a: FYPO:0000408 ! increased duration of cell cycle phase is_a: FYPO:0002738 ! abnormal meiotic cell cycle phase intersection_of: PATO:0000498 ! increased duration intersection_of: during GO:0051321 ! meiotic cell cycle intersection_of: inheres_in GO:0022403 ! cell cycle phase relationship: during GO:0051321 ! meiotic cell cycle relationship: inheres_in GO:0022403 ! cell cycle phase created_by: midori creation_date: 2013-06-05T16:26:25Z [Term] id: FYPO:0002221 name: increased duration of meiotic anaphase II def: "A cellular process phenotype in which the duration of progression through the anaphase of meiosis II is longer than normal." [PomBase:mah] synonym: "delayed meiotic anaphase II progression" RELATED [PomBase:mah] synonym: "increased duration of meiotic anaphase II progression" EXACT [PomBase:mah] synonym: "prolonged meiotic anaphase II" EXACT [PomBase:mah] is_a: FYPO:0002220 ! increased duration of meiotic cell cycle phase intersection_of: PATO:0000498 ! increased duration intersection_of: inheres_in GO:0007134 ! meiotic telophase I relationship: inheres_in GO:0007134 ! meiotic telophase I created_by: midori creation_date: 2013-06-05T16:27:42Z [Term] id: FYPO:0002222 name: long meiosis II spindle def: "A spindle phenotype in which the meiotic spindle is longer than normal during meiosis II." [PomBase:mah] synonym: "elongated meiosis II spindle" EXACT [PomBase:mah] synonym: "long spindle during meiosis II" EXACT [PomBase:mah] is_a: FYPO:0000736 ! long meiotic spindle intersection_of: PATO:0000573 ! increased length intersection_of: exists_during GO:0007135 ! meiosis II intersection_of: inheres_in GO:0072687 ! meiotic spindle relationship: exists_during GO:0007135 ! meiosis II relationship: inheres_in GO:0072687 ! meiotic spindle created_by: midori creation_date: 2013-06-05T16:35:26Z [Term] id: FYPO:0002223 name: abnormal cell cycle arrest in meiosis II def: "A cellular process phenotype in which progression through the meiotic cell cycle is arrested in meiosis II. Meiosis II is the second phase of meiosis, in which cells divide and separate the two chromatids in each chromosome." [GO:0007135, PomBase:mah] is_a: FYPO:0002224 ! abnormally arrested meiotic cell cycle intersection_of: PATO:0001561 ! having extra processual parts intersection_of: during GO:0007135 ! meiosis II intersection_of: towards GO:0007050 ! cell cycle arrest relationship: during GO:0007135 ! meiosis II relationship: towards GO:0007050 ! cell cycle arrest created_by: midori creation_date: 2013-06-05T16:40:26Z [Term] id: FYPO:0002224 name: abnormally arrested meiotic cell cycle def: "A cellular process phenotype in which progression through the meiotic cell cycle is arrested under conditions where arrest does not normally occur." [PomBase:mah] is_a: FYPO:0000052 ! abnormal meiotic cell cycle is_a: FYPO:0000407 ! abnormally arrested cell cycle progression intersection_of: PATO:0001561 ! having extra processual parts intersection_of: during GO:0051321 ! meiotic cell cycle intersection_of: towards GO:0007050 ! cell cycle arrest relationship: during GO:0051321 ! meiotic cell cycle relationship: towards GO:0007050 ! cell cycle arrest created_by: midori creation_date: 2013-06-05T16:41:00Z [Term] id: FYPO:0002225 name: inviable microcolony, elongated cells def: "A cell population phenotype in which a cell undergoes one or a few rounds of cell division before cells die, resulting in the formation a colony that contains only a few inviable cells that are longer than normal. Up to 6 rounds of cell division (generating 64 cells) may be observed, but 3 divisions or fewer is more typical." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype, with penetrance extensions where needed. synonym: "inviable microcolony, elongated vegetative cells" EXACT [PomBase:mah] synonym: "inviable microcolony, long cells" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-06-05T16:45:49Z [Term] id: FYPO:0002226 name: inviable microcolony, abnormal cell shape, normal cell size def: "A cell population phenotype in which a cell undergoes one or a few rounds of cell division before cells die, resulting in the formation a colony that contains only a few inviable cells in which cell shape is altered and cell size remains normal. Up to 6 rounds of cell division (generating 64 cells) may be observed, but 3 divisions or fewer is more typical." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype, with penetrance extensions where needed. is_obsolete: true created_by: midori creation_date: 2013-06-05T16:52:35Z [Term] id: FYPO:0002227 name: increased cellular triglyceride level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more triglycerides measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular TAG level" EXACT [PomBase:mah] synonym: "increased cellular triacylglycerol level" EXACT [PomBase:mah] synonym: "increased cellular triglyceride level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular triglyceride level during vegetative growth" EXACT [PomBase:mah] synonym: "increased triglyceride accumulation" RELATED [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:17855 ! triglyceride relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:17855 ! triglyceride created_by: midori creation_date: 2013-06-05T17:03:18Z [Term] id: FYPO:0002228 name: normal cellular phosphatidylethanolamine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of phosphatidylethanolamine measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular PE level" EXACT [PomBase:mah] synonym: "normal cellular phosphatidylethanolamine accumulation" RELATED [PomBase:mah] synonym: "normal cellular phosphatidylethanolamine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular phosphatidylethanolamine level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001543 ! normal cellular phosphorus level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:16038 ! phosphatidylethanolamine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:16038 ! phosphatidylethanolamine created_by: midori creation_date: 2013-06-05T17:05:15Z [Term] id: FYPO:0002229 name: normal cellular ergosterol level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of ergosterol measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular ergosterol accumulation" RELATED [PomBase:mah] synonym: "normal cellular ergosterol level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular ergosterol level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:16933 ! ergosterol relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:16933 ! ergosterol created_by: midori creation_date: 2013-06-05T17:07:25Z [Term] id: FYPO:0002230 name: inviable swollen curved vegetative cell def: "A cell morphology phenotype in which a vegetatively growing cell is inviable, has a larger volume than normal, and is curved along the long axis. In a curved cell, the long axis follows a smooth bend rather than a straight line. In a swollen cell, both length and diameter are greater than normal, although the cell is only considered elongated if the length:width ratio is also greater than normal." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "essential; swollen curved vegetative cell" RELATED [PomBase:mah] synonym: "inviable curved cell with increased cell size" RELATED [PomBase:vw] synonym: "inviable curved cell with increased cell volume" EXACT [PomBase:mah] synonym: "inviable enlarged curved cell" RELATED [PomBase:mah] synonym: "inviable large curved cell" RELATED [PomBase:vw] synonym: "inviable swollen curved cell" EXACT [PomBase:mah] synonym: "inviable swollen curved cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable swollen curved inviable cell" EXACT [PomBase:mah] synonym: "inviable swollen curved vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0002113 ! inviable curved vegetative cell is_a: FYPO:0002415 ! inviable swollen vegetative cell with abnormal cell shape intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000016 ! curved vegetative cell intersection_of: has_part FYPO:0000025 ! swollen cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000016 ! curved vegetative cell relationship: has_part FYPO:0000025 ! swollen cell relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2013-06-06T14:15:53Z [Term] id: FYPO:0002231 name: inviable microcolony, curved cells def: "A cell population phenotype in which a cell undergoes one or a few rounds of cell division before cells die, resulting in the formation a colony that contains only a few inviable cells that are curved along the long axis. Up to 6 rounds of cell division (generating 64 cells) may be observed, but 3 divisions or fewer is more typical." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype, with penetrance extensions where needed. synonym: "inviable microcolony, curved vegetative cells" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-06-06T14:18:49Z [Term] id: FYPO:0002232 name: inviable microcolony, swollen curved cells def: "A cell population phenotype in which a cell undergoes one or a few rounds of cell division before cells die, resulting in the formation a colony that contains only a few inviable cells that have a larger volume than normal and are curved along the long axis. Up to 6 rounds of cell division (generating 64 cells) may be observed, but 3 divisions or fewer is more typical." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype, with penetrance extensions where needed. synonym: "inviable microcolony, curved cells with increased cell size" RELATED [PomBase:vw] synonym: "inviable microcolony, curved cells with increased cell volume" EXACT [PomBase:mah] synonym: "inviable microcolony, enlarged curved cells" RELATED [PomBase:mah] synonym: "inviable microcolony, large curved cells" RELATED [PomBase:vw] synonym: "inviable microcolony, swollen curved vegetative cells" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-06-06T14:19:36Z [Term] id: FYPO:0002233 name: viable elongated vegetative cell population alt_id: FYPO:0002278 def: "A cell population phenotype in which all cells in the population are viable but longer than normal in the vegetative growth phase of the life cycle." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. synonym: "population of viable long cells" EXACT [PomBase:vw] synonym: "viable long vegetative cell population" EXACT [PomBase:mah] synonym: "viable population of elongated vegetative cells" EXACT [PomBase:vw] is_obsolete: true replaced_by: FYPO:0002060 created_by: midori creation_date: 2013-06-06T14:39:45Z [Term] id: FYPO:0002234 name: decreased cellular sterol ester level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more sterol esters measured in a cell is lower than normal." [PomBase:mah] synonym: "decreased cellular sterol ester level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular sterol ester level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased level of sterol ester in cell" EXACT [PomBase:mah] synonym: "decreased sterol ester accumulation" RELATED [PomBase:al] synonym: "reduced cellular sterol ester level" EXACT [PomBase:mah] synonym: "reduced level of sterol ester in cell" EXACT [PomBase:mah] is_a: FYPO:0001329 ! decreased level of substance in cell during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:35915 ! sterol ester relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:35915 ! sterol ester created_by: midori creation_date: 2013-06-06T15:18:37Z [Term] id: FYPO:0002235 name: increased cellular sterol ester level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more sterol esters measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular sterol ester level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular sterol ester level during vegetative growth" EXACT [PomBase:mah] synonym: "increased sterol ester accumulation" RELATED [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:35915 ! sterol ester relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:35915 ! sterol ester created_by: midori creation_date: 2013-06-06T15:20:19Z [Term] id: FYPO:0002236 name: normal cellular sterol ester level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more sterol esters measured in the cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular sterol ester level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular sterol ester level during vegetative growth" EXACT [PomBase:mah] synonym: "normal level of sterol ester in cell" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:35915 ! sterol ester relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:35915 ! sterol ester created_by: midori creation_date: 2013-06-06T15:21:32Z [Term] id: FYPO:0002237 name: sensitive to cerulenin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to cerulenin. Cells stop growing (and may die) at a concentration of cerulenin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to cerulenin" EXACT [PomBase:mah] synonym: "sensitive to cerulenin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to cerulenin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:171741 ! cerulenin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:171741 ! cerulenin created_by: midori creation_date: 2013-06-06T15:30:42Z [Term] id: FYPO:0002238 name: normal growth on cerulenin def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing cerulenin." [PomBase:mah] synonym: "normal cell population growth in presence of cerulenin" EXACT [PomBase:mah] synonym: "normal cell population growth on cerulenin" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to cerulenin" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on cerulenin" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:171741 ! cerulenin relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:171741 ! cerulenin created_by: midori creation_date: 2013-06-06T15:32:04Z [Term] id: FYPO:0002239 name: shortened telomeres def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells form telomeres that are shorter than normal." [PomBase:mah] synonym: "decreased telomere length" EXACT [PomBase:mah] synonym: "reduced telomere length" EXACT [PomBase:mah] synonym: "short telomeres" EXACT [PomBase:mah] synonym: "shortened telomeres during mitotic cell cycle" RELATED [PomBase:mah] synonym: "shortened telomeres during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002254 ! abnormal telomere morphology is_a: PATO:0000574 ! decreased length intersection_of: PATO:0000574 ! decreased length intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000781 ! chromosome, telomeric region relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000781 ! chromosome, telomeric region created_by: midori creation_date: 2013-06-06T15:38:03Z [Term] id: FYPO:0002240 name: swollen septated spheroid vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is shaped in the form of a spheroid, has one or more septa, and has a larger volume than normal. In a swollen cell, both length and diameter are greater than normal, although the cell is only considered elongated if the length:width ratio is also greater than normal." [PomBase:mah] synonym: "enlarged septated spheroid vegetative cell" RELATED [PomBase:mah] synonym: "large septated spheroid vegetative cell" RELATED [PomBase:vw] synonym: "septated spheroid vegetative cell with increased cell size" RELATED [PomBase:vw] synonym: "septated spheroid vegetative cell with increased cell volume" EXACT [PomBase:mah] synonym: "swollen septated rounded vegetative cell" EXACT [PomBase:mah] is_a: FYPO:0000945 ! swollen spheroid vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000021 ! spheroid vegetative cell intersection_of: has_part FYPO:0000025 ! swollen cell intersection_of: has_part FYPO:0002342 ! septated vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000021 ! spheroid vegetative cell relationship: has_part FYPO:0000025 ! swollen cell relationship: has_part FYPO:0002342 ! septated vegetative cell created_by: midori creation_date: 2013-06-06T16:24:19Z [Term] id: FYPO:0002241 name: normal volume septated spheroid vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is shaped in the form of a spheroid, has one or more septa, and has a normal volume." [PomBase:mah] synonym: "normal volume septated rounded vegetative cell" EXACT [PomBase:mah] is_a: FYPO:0000946 ! normal volume spheroid vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000021 ! spheroid vegetative cell intersection_of: has_part FYPO:0000926 ! normal volume vegetative cell intersection_of: has_part FYPO:0002342 ! septated vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000021 ! spheroid vegetative cell relationship: has_part FYPO:0000926 ! normal volume vegetative cell relationship: has_part FYPO:0002342 ! septated vegetative cell created_by: midori creation_date: 2013-06-06T16:26:51Z [Term] id: FYPO:0002242 name: inviable elongated tapered vegetative cell def: "A cell morphology phenotype in which a vegetatively growing cell is inviable, is longer than normal, and tapers at one end to a diameter smaller than the other. The cell diameter at the narrow end is smaller than that of a wild-type cell." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "essential; elongated tapered vegetative cell" RELATED [PomBase:mah] synonym: "inviable elongated bottle-shaped vegetative cell" EXACT [PomBase:vw] synonym: "inviable elongated bottle-shaped vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable elongated bottle/skittle vegetative cell" EXACT [PomBase:mah] synonym: "inviable elongated skittle-shaped vegetative cell" EXACT [PomBase:mah] synonym: "inviable elongated tapered cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable long tapered vegetative cell" EXACT [PomBase:mah] is_a: FYPO:0001490 ! inviable elongated vegetative cell is_a: FYPO:0002111 ! inviable tapered vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000014 ! tapered cell intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000014 ! tapered cell relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2013-06-06T16:28:17Z [Term] id: FYPO:0002243 name: increased acid phosphatase activity def: "A molecular function phenotype in which the observed rate of acid phosphatase activity is increased." [PomBase:mah] is_a: FYPO:0001044 ! abnormal acid phosphatase activity is_a: FYPO:0004415 ! increased phosphatase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0003993 ! acid phosphatase activity relationship: inheres_in GO:0003993 ! acid phosphatase activity created_by: midori creation_date: 2013-06-06T16:31:24Z [Term] id: FYPO:0002244 name: abolished acid phosphatase activity def: "A molecular function phenotype in which acid phosphatase activity is absent." [PomBase:mah] synonym: "acid phosphatase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0001044 ! abnormal acid phosphatase activity is_a: FYPO:0004303 ! abolished phosphatase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0003993 ! acid phosphatase activity relationship: towards GO:0003993 ! acid phosphatase activity created_by: midori creation_date: 2013-06-06T16:36:41Z [Term] id: FYPO:0002245 name: abnormal monosaccharide binding def: "A molecular function phenotype in which occurrence of monosaccharide binding by a gene product (usually a protein) in a mutant is abnormal. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] is_a: FYPO:0000707 ! abnormal molecular function is_a: FYPO:0001092 ! binding phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0048029 ! monosaccharide binding intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0048029 ! monosaccharide binding relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-06-06T16:38:57Z [Term] id: FYPO:0002246 name: increased glucose binding def: "A molecular function phenotype in which occurrence of glucose binding by a gene product (usually a protein) in a mutant is increased. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] comment: This term can mean that the mutated gene product itself binds glucose more than wild type, or that a mutation in one gene increases glucose binding by a second gene product. When using this term, it is therefore recommended to note the specific protein(s) affected. is_a: FYPO:0002245 ! abnormal monosaccharide binding is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0005536 ! glucose binding relationship: inheres_in GO:0005536 ! glucose binding created_by: midori creation_date: 2013-06-06T16:42:50Z [Term] id: FYPO:0002247 name: decreased glucose binding def: "A molecular function phenotype in which occurrence of glucose binding by a gene product (usually a protein) in a mutant is decreased. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] comment: This term can mean that the mutated gene product itself binds glucose less than wild type, or that a mutation in one gene decreases glucose binding by a second gene product. When using this term, it is therefore recommended to note the specific protein(s) affected. synonym: "reduced glucose binding" EXACT [PomBase:mah] is_a: FYPO:0002245 ! abnormal monosaccharide binding is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0005536 ! glucose binding relationship: inheres_in GO:0005536 ! glucose binding created_by: midori creation_date: 2013-06-06T16:43:20Z [Term] id: FYPO:0002248 name: increased mannose binding def: "A molecular function phenotype in which occurrence of mannose binding by a gene product (usually a protein) in a mutant is increased. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] comment: This term can mean that the mutated gene product itself binds mannose more than wild type, or that a mutation in one gene increases mannose binding by a second gene product. When using this term, it is therefore recommended to note the specific protein(s) affected. is_a: FYPO:0002245 ! abnormal monosaccharide binding is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0005537 ! mannose binding relationship: inheres_in GO:0005537 ! mannose binding created_by: midori creation_date: 2013-06-06T16:43:54Z [Term] id: FYPO:0002249 name: decreased fructose binding def: "A molecular function phenotype in which occurrence of fructose binding by a gene product (usually a protein) in a mutant is decreased. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] comment: This term can mean that the mutated gene product itself binds fructose less than wild type, or that a mutation in one gene decreases fructose binding by a second gene product. When using this term, it is therefore recommended to note the specific protein(s) affected. synonym: "reduced fructose binding" EXACT [PomBase:mah] is_a: FYPO:0002245 ! abnormal monosaccharide binding is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0070061 ! fructose binding relationship: inheres_in GO:0070061 ! fructose binding created_by: midori creation_date: 2013-06-06T16:44:19Z [Term] id: FYPO:0002250 name: inviable curved vacuolated vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is inviable, is curved along the long axis, and in which vacuoles are more visible (usually by microscopy) than normal." [PomBase:mah] synonym: "essential; curved vacuolated vegetative cell" RELATED [PomBase:mah] synonym: "inviable curved vacuolated cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable curved vacuolated vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0002113 ! inviable curved vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000016 ! curved vegetative cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0001581 ! vacuolated relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000016 ! curved vegetative cell relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0001581 ! vacuolated created_by: midori creation_date: 2013-06-07T15:30:03Z [Term] id: FYPO:0002251 name: inviable swollen elongated vegetative cell def: "A cell morphology phenotype in which a vegetative cell is inviable and has a larger volume, and is longer, than normal. In a swollen cell, both length and diameter are greater than normal, although the cell is only considered elongated if the length:width ratio is also greater than normal." [PomBase:mah] synonym: "inviable elongated cell with increased cell volume" EXACT [PomBase:mah] synonym: "inviable enlarged elongated cell" RELATED [PomBase:mah] synonym: "inviable large elongated cell" RELATED [PomBase:vw] synonym: "inviable swollen elongated cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable swollen elongated vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001429 ! swollen elongated cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000025 ! swollen cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000025 ! swollen cell relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2013-06-07T15:48:12Z [Term] id: FYPO:0002252 name: inviable swollen elongated mononucleate vegetative cell with normally localized septum def: "A cell phenotype in which a cell contains a single septum, has one nucleus, is elongated, and is inviable. The septum is in an abnormal location, and the nucleus is located in one compartment of the septated cell. The cell compartment containing the nucleus is swollen (i.e. has a larger diameter and volume than the other compartment)." [PomBase:mah, PomBase:vw] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "inviable elongated mononucleate vegetative cell with normally localized septum with increased cell volume" EXACT [PomBase:mah] synonym: "inviable enlarged elongated mononucleate vegetative cell with normally localized septum" RELATED [PomBase:mah] synonym: "inviable large elongated mononucleate vegetative cell with normally localized septum" RELATED [PomBase:vw] synonym: "inviable swollen elongated mononucleate vegetative cell with normally localised septum" EXACT [PomBase:mah] synonym: "inviable swollen elongated mononucleate vegetative cell with normally localized septum during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable swollen elongated mononucleate vegetative cell with normally positioned septum" EXACT [PomBase:mah] synonym: "long swollen mononucleate cell with normally localized septum" EXACT [PomBase:vw] synonym: "swollen elongated mononucleate cell with normal septum position" NARROW [PomBase:mah] synonym: "swollen elongated mononucleate cell with normally localized septum near new end during vegetative growth" EXACT [PomBase:mah] synonym: "swollen elongated mononucleate cell with normally placed septum" EXACT [PomBase:vw] is_a: FYPO:0001917 ! elongated mononucleate monoseptate vegetative cell is_a: FYPO:0002103 ! inviable swollen mononucleate monoseptate vegetative cell is_a: FYPO:0002415 ! inviable swollen vegetative cell with abnormal cell shape is_a: FYPO:0002845 ! inviable swollen elongated septated cell is_a: FYPO:0004255 ! inviable elongated mononucleate vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000025 ! swollen cell intersection_of: has_part FYPO:0000060 ! mononucleate vegetative cell intersection_of: has_part FYPO:0001225 ! monoseptate intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0002253 ! normal septum location relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000025 ! swollen cell relationship: has_part FYPO:0000060 ! mononucleate vegetative cell relationship: has_part FYPO:0001225 ! monoseptate relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0002253 ! normal septum location created_by: midori creation_date: 2013-06-07T16:00:55Z [Term] id: FYPO:0002253 name: normal septum location def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which a cell has a septum in the normal location at the midpoint of the long axis of the cell." [PomBase:mah] synonym: "normal septum location during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal septum location during vegetative growth" EXACT [PomBase:mah] synonym: "normal septum position" RELATED [PomBase:mah] synonym: "normally localized septum" EXACT [PomBase:mah] is_a: FYPO:0001233 ! normal subcellular component is_a: PATO:0000140 ! position intersection_of: PATO:0000140 ! position intersection_of: inheres_in GO:0000935 ! barrier septum intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0000935 ! barrier septum relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-06-07T16:05:04Z [Term] id: FYPO:0002254 name: abnormal telomere morphology def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of the telomere is abnormal." [PomBase:mah] comment: Note that an abnormal telomere organization process may, but does not necessarily, result in abnormal telomere morphology. synonym: "abnormal telomere morphology during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal telomere morphology during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000781 ! chromosome, telomeric region intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000781 ! chromosome, telomeric region relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-06-11T13:43:06Z [Term] id: FYPO:0002255 name: enlarged nucleus def: "A physical cellular phenotype in which the nucleus is larger than normal." [PomBase:mah] synonym: "enlarged nuclei" EXACT [PomBase:vw] is_a: FYPO:0002256 ! abnormal nuclear morphology is_a: PATO:0000586 ! increased size intersection_of: PATO:0000586 ! increased size intersection_of: inheres_in GO:0005634 ! nucleus relationship: inheres_in GO:0005634 ! nucleus created_by: midori creation_date: 2013-06-11T16:39:47Z [Term] id: FYPO:0002256 name: abnormal nuclear morphology def: "A physical cellular phenotype in which the size, shape, or structure of the nucleus is abnormal." [PomBase:mah] comment: Note that an abnormal nucleus organization process may, but does not necessarily, result in abnormal nuclear morphology. synonym: "nuclear morphology defects" EXACT [PomBase:mah] is_a: FYPO:0002403 ! abnormal nucleus is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: inheres_in GO:0005634 ! nucleus intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0005634 ! nucleus relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-06-11T16:40:13Z [Term] id: FYPO:0002257 name: abnormal vacuolar morphology def: "A physical cellular phenotype in which the size, shape, or structure of the fungal-type vacuole is abnormal." [PomBase:mah] comment: Note that an abnormal vacuole organization process may, but does not necessarily, result in abnormal vacuolar morphology. synonym: "vacuolar morphology: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0002794 ! abnormal vacuole is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-06-11T17:16:05Z [Term] id: FYPO:0002258 name: small vacuoles present in greater numbers def: "A cell phenotype in which a cell contains more, but smaller, vacuoles than normal." [PomBase:mah] synonym: "fragmented vacuoles" RELATED [PomBase:mah] synonym: "vacuole organization defects, fragmented vacuoles" RELATED [PomBase:mah] is_a: FYPO:0004638 ! abnormal cellular physical quality phenotype intersection_of: FYPO:0004638 ! abnormal cellular physical quality phenotype intersection_of: has_part FYPO:0002787 ! small vacuoles intersection_of: has_part FYPO:0002790 ! vacuoles present in greater numbers relationship: has_part FYPO:0002787 ! small vacuoles relationship: has_part FYPO:0002790 ! vacuoles present in greater numbers created_by: midori creation_date: 2013-06-11T17:18:14Z [Term] id: FYPO:0002259 name: normal leucine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which L-leucine import into the cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal L-leucine import" NARROW [PomBase:mah] synonym: "normal leucine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal leucine import during vegetative growth" EXACT [PomBase:mah] synonym: "normal leucine import into cell" EXACT [PomBase:al] synonym: "normal leucine uptake" EXACT [PomBase:mah] is_a: FYPO:0001071 ! normal transport is_a: FYPO:0001336 ! transport phenotype during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903801 ! L-leucine import into cell intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903801 ! L-leucine import into cell relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-06-12T13:18:44Z [Term] id: FYPO:0002260 name: normal glutamate import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which L-glutamate import into the cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal glutamate import" EXACT [PomBase:mah] synonym: "normal glutamate import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal glutamate import during vegetative growth" EXACT [PomBase:mah] synonym: "normal glutamate import into cell" EXACT [PomBase:al] synonym: "normal glutamate uptake" EXACT [PomBase:mah] synonym: "normal glutamic acid import" EXACT [PomBase:mah] synonym: "normal L-glutamic acid import" EXACT [PomBase:mah] is_a: FYPO:0001336 ! transport phenotype during vegetative growth is_a: FYPO:0001596 ! normal amino acid import intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990123 ! L-glutamate import into cell intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990123 ! L-glutamate import into cell relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-06-12T13:21:09Z [Term] id: FYPO:0002261 name: abnormal N-glycan processing def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which N-glycan processing is abnormal." [PomBase:mah] synonym: "abnormal N-glycan catabolism" RELATED [GO:0006491] synonym: "abnormal N-glycan degradation" RELATED [GO:0006491] synonym: "abnormal N-glycan processing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal N-glycan processing during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal N-linked glycoprotein maturation" EXACT [GO:0006491] is_a: FYPO:0000860 ! abnormal metabolic process is_a: FYPO:0001348 ! cellular metabolism phenotype during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006491 ! N-glycan processing intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006491 ! N-glycan processing relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-06-12T13:53:52Z [Term] id: FYPO:0002262 name: inviable after spore germination, multiple cell divisions, elongated cell def: "A phenotype in which a spore germinates to produce a cell that is elongated, and undergoes two or more rounds of cell division and then dies." [PomBase:al, PomBase:mah] synonym: "essential; germinating spore, multiple cell divisions, elongated cell" RELATED [PomBase:mah] synonym: "inviable following spore germination, multiple cell divisions, elongated cell" EXACT [PomBase:mah] synonym: "inviable germinated spore, multiple cell divisions, elongated cell" EXACT [PomBase:mah] is_a: FYPO:0001490 ! inviable elongated vegetative cell is_a: FYPO:0002148 ! inviable after spore germination, multiple cell divisions, abnormal morphology created_by: midori creation_date: 2013-06-12T14:07:08Z [Term] id: FYPO:0002263 name: inviable after spore germination, without cell division, cell cycle arrest, elongated cell def: "A phenotype in which a spore germinates to produce a cell that enters the cell cycle but then becomes elongated and undergoes cell cycle arrest, and eventually dies without completing cell division." [PomBase:mah] synonym: "inviable germinated spore, without cell division, cell cycle arrest, elongated cell" EXACT [PomBase:mah] is_a: FYPO:0001924 ! inviable after spore germination, without cell division, cell cycle arrest is_a: FYPO:0004603 ! inviable after spore germination, without cell division, elongated cell created_by: midori creation_date: 2013-06-12T14:30:44Z [Term] id: FYPO:0002264 name: increased concentration of polysaccharide in growth medium def: "A phenotype in which the concentration of one or more polysaccharides released into the growth medium by cells is higher than normal." [PomBase:mah] synonym: "increased concentration of polysaccharides in growth medium" EXACT [PomBase:al] synonym: "increased level of polysaccharide in growth medium" EXACT [PomBase:mah] synonym: "increased release of polysaccharide into growth medium" RELATED [PomBase:mah] is_a: FYPO:0000800 ! increased concentration of substance in growth medium intersection_of: PATO:0001162 ! increased concentration intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: towards CHEBI:18154 ! polysaccharide relationship: inheres_in BTO:0000316 ! culture medium relationship: towards CHEBI:18154 ! polysaccharide created_by: midori creation_date: 2013-06-12T14:46:22Z [Term] id: FYPO:0002265 name: decreased cell wall galactomannan level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of galactomannan measured in the cell wall is lower than normal." [PomBase:mah] synonym: "decreased cell wall galactomannan accumulation" RELATED [PomBase:mah] synonym: "decreased cell wall galactomannan level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cell wall galactomannan level during vegetative growth" EXACT [PomBase:mah] synonym: "reduced cell wall galactomannan level" EXACT [PomBase:mah] is_a: FYPO:0001082 ! decreased cell wall beta-glucan level is_a: FYPO:0001195 ! decreased galactomannan level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0009277 ! fungal-type cell wall intersection_of: towards CHEBI:27680 ! galactomannan relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0009277 ! fungal-type cell wall relationship: towards CHEBI:27680 ! galactomannan created_by: midori creation_date: 2013-06-12T14:48:20Z [Term] id: FYPO:0002266 name: decreased cell wall polysaccharide level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more polysaccharides measured in the cell wall is lower than normal." [PomBase:mah] synonym: "decreased cell wall polysaccharide accumulation" RELATED [PomBase:mah] synonym: "decreased cell wall polysaccharide level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cell wall polysaccharide level during vegetative growth" EXACT [PomBase:mah] synonym: "reduced cell wall polysaccharide level" EXACT [PomBase:mah] is_a: FYPO:0001080 ! decreased polysaccharide level is_a: FYPO:0002628 ! decreased level of substance in cell wall intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0009277 ! fungal-type cell wall intersection_of: towards CHEBI:18154 ! polysaccharide relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0009277 ! fungal-type cell wall relationship: towards CHEBI:18154 ! polysaccharide created_by: midori creation_date: 2013-06-12T14:48:41Z [Term] id: FYPO:0002267 name: abnormal glutamate-ammonia ligase activity def: "A molecular function phenotype in which the observed rate of glutamate-ammonia ligase activity is abnormal." [PomBase:mah] synonym: "abnormal glutamine synthetase activity" EXACT [GO:0004356, PomBase:mah] synonym: "abnormal glutamylhydroxamic synthetase activity" EXACT [GO:0004356] synonym: "normal GS activity" EXACT [PMID:7851743, PomBase:al] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004356 ! glutamate-ammonia ligase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004356 ! glutamate-ammonia ligase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-06-12T14:55:51Z [Term] id: FYPO:0002268 name: abolished glutamate-ammonia ligase activity def: "A molecular function phenotype in which glutamate-ammonia ligase activity is absent." [PomBase:mah] synonym: "abolished glutamine synthetase activity" EXACT [GO:0004356, PomBase:mah] synonym: "abolished glutamylhydroxamic synthetase activity" EXACT [GO:0004356] synonym: "abolished GS activity" EXACT [PMID:7851743, PomBase:al] synonym: "glutamate-ammonia ligase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0002267 ! abnormal glutamate-ammonia ligase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0004356 ! glutamate-ammonia ligase activity relationship: towards GO:0004356 ! glutamate-ammonia ligase activity created_by: midori creation_date: 2013-06-12T14:56:05Z [Term] id: FYPO:0002269 name: decreased glutamate-ammonia ligase activity def: "A molecular function phenotype in which the observed rate of glutamate-ammonia ligase activity is decreased." [PomBase:mah] synonym: "decreased glutamine synthetase activity" EXACT [GO:0004356, PomBase:mah] synonym: "decreased glutamylhydroxamic synthetase activity" EXACT [GO:0004356] synonym: "decreased GS activity" EXACT [PMID:7851743, PomBase:al] synonym: "reduced glutamate-ammonia ligase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0002267 ! abnormal glutamate-ammonia ligase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004356 ! glutamate-ammonia ligase activity relationship: inheres_in GO:0004356 ! glutamate-ammonia ligase activity created_by: midori creation_date: 2013-06-12T14:56:15Z [Term] id: FYPO:0002270 name: increased glutamate-ammonia ligase activity def: "A molecular function phenotype in which the observed rate of glutamate-ammonia ligase activity is increased." [PomBase:mah] synonym: "increased glutamine synthetase activity" EXACT [GO:0004356, PomBase:mah] synonym: "increased glutamylhydroxamic synthetase activity" EXACT [GO:0004356] synonym: "increased GS activity" EXACT [PMID:7851743, PomBase:al] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0002267 ! abnormal glutamate-ammonia ligase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0004356 ! glutamate-ammonia ligase activity relationship: inheres_in GO:0004356 ! glutamate-ammonia ligase activity created_by: midori creation_date: 2013-06-12T14:56:22Z [Term] id: FYPO:0002271 name: growth auxotrophic for glutamine def: "Auxotrophy in which a cell is unable to synthesize glutamine, and therefore requires glutamine in the medium for vegetative cell growth." [PomBase:mah] synonym: "glutamine auxotrophy" EXACT [PomBase:mah] synonym: "growth auxotrophic for glutamine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "growth auxotrophic for glutamine during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000128 ! auxotrophy is_a: PATO:0000422 ! auxotrophic intersection_of: PATO:0000422 ! auxotrophic intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:18050 ! L-glutamine relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:18050 ! L-glutamine created_by: midori creation_date: 2013-06-12T15:00:33Z [Term] id: FYPO:0002272 name: inviable microcolony, abnormal cell morphology def: "A cell population phenotype in which a cell undergoes one or a few rounds of cell division before cells die, resulting in the formation a colony that contains only a few inviable cells that have abnormal morphology (i.e. size, shape, or structure). Up to 6 rounds of cell division (generating 64 cells) may be observed, but 3 divisions or fewer is more typical." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype, with penetrance extensions where needed. synonym: "inviable microcolony, vegetative cells with abnormal morphology" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-06-12T15:37:46Z [Term] id: FYPO:0002273 name: inviable vegetative cell with abnormal cell morphology def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell has abnormal morphology (i.e. size, shape, or structure) and is inviable." [PomBase:mah] synonym: "inviable cell with abnormal cell morphology during vegetative growth" EXACT [PomBase:mah] synonym: "inviable vegetative cell with abnormal cell morphology during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000049 ! inviable cell is_a: FYPO:0001321 ! cellular physical quality phenotype during vegetative growth intersection_of: FYPO:0000049 ! inviable cell intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0001118 ! abnormal vegetative cell morphology relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0001118 ! abnormal vegetative cell morphology created_by: midori creation_date: 2013-06-12T15:40:14Z [Term] id: FYPO:0002274 name: abnormal protein metabolic process def: "A cellular process phenotype that affects protein metabolism in the cell." [PomBase:mah] synonym: "abnormal cellular protein metabolic process" EXACT [PomBase:mah] is_a: FYPO:0000860 ! abnormal metabolic process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0044267 ! cellular protein metabolic process intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0044267 ! cellular protein metabolic process relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-06-12T15:51:09Z [Term] id: FYPO:0002275 name: abnormal protein degradation def: "A cellular process phenotype in which protein degradation is abnormal. Protein degradation, also known as protein catabolism, is any metabolic process that results in the destruction of the native, active configuration of a protein, with or without the hydrolysis of peptide bonds." [GO:0030163, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein breakdown" EXACT [GO:0030163, PomBase:mah] synonym: "abnormal protein catabolic process" EXACT [GO:0030163, PomBase:mah] synonym: "abnormal protein catabolism" EXACT [GO:0030163, PomBase:mah] is_a: FYPO:0002274 ! abnormal protein metabolic process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0030163 ! protein catabolic process intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0030163 ! protein catabolic process relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-06-12T15:53:25Z [Term] id: FYPO:0002276 name: increased protein degradation def: "A cellular process phenotype in which the occurrence of protein degradation is increased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein breakdown" EXACT [GO:0030163, PomBase:mah] synonym: "increased protein catabolic process" EXACT [GO:0030163, PomBase:mah] synonym: "increased protein catabolism" EXACT [GO:0030163, PomBase:mah] is_a: FYPO:0002275 ! abnormal protein degradation is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0030163 ! protein catabolic process relationship: has_output FYPO:0000835 ! decreased protein level relationship: inheres_in GO:0030163 ! protein catabolic process created_by: midori creation_date: 2013-06-12T15:56:44Z [Term] id: FYPO:0002277 name: increased protein degradation during nitrogen starvation def: "A cellular process phenotype in which the occurrence of protein degradation is increased when the cell is subject to nitrogen starvation." [PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein breakdown during nitrogen starvation" EXACT [GO:0030163, PomBase:mah] synonym: "increased protein catabolic process during nitrogen starvation" EXACT [GO:0030163, PomBase:mah] synonym: "increased protein catabolism during nitrogen starvation" EXACT [GO:0030163, PomBase:mah] synonym: "increased protein degradation during nitrogen depletion" EXACT [PomBase:vw] synonym: "increased protein degradation during nitrogen deprivation" EXACT [PomBase:vw] is_a: FYPO:0002276 ! increased protein degradation is_a: FYPO:0002796 ! abnormal protein degradation during nitrogen starvation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in GO:0030163 ! protein catabolic process relationship: happens_during GO:0006995 ! cellular response to nitrogen starvation relationship: has_output FYPO:0001283 ! decreased protein level during cellular response to nitrogen starvation relationship: inheres_in GO:0030163 ! protein catabolic process created_by: midori creation_date: 2013-06-12T15:59:06Z [Term] id: FYPO:0002279 name: inviable after spore germination, single cell division, with elongated, curved germ tube def: "A phenotype in which a spore germinates to produce an elongated germ tube that is curved along the long axis, and undergoes a single round of cell division." [PomBase:mah] synonym: "essential; germinating spore, single cell division, with elongated, curved germ tube" RELATED [PomBase:mah] synonym: "inviable after spore germination, single cell division, elongated, curved cell" EXACT [PomBase:mah] synonym: "inviable following spore germination, single cell division, with elongated, curved germ tube" EXACT [PomBase:mah] synonym: "inviable germinated spore, single cell division, with elongated, curved germ tube" EXACT [PomBase:mah] is_a: FYPO:0002409 ! inviable after spore germination, single cell division, with elongated germ tube created_by: midori creation_date: 2013-06-12T16:14:09Z [Term] id: FYPO:0002280 name: inviable after spore germination, single cell division def: "A phenotype in which a spore germinates to produce a cell that undergoes a single round of cell division, and then dies." [PomBase:jh, PomBase:mah, PomBase:vw] synonym: "essential; germinating spore, single cell division" RELATED [PomBase:mah] synonym: "inviable following spore germination, single cell division" EXACT [PomBase:mah] synonym: "inviable germinated spore, single cell division" EXACT [PomBase:mah] is_a: FYPO:0000316 ! inviable after spore germination created_by: midori creation_date: 2013-06-12T16:15:22Z [Term] id: FYPO:0002281 name: inviable after spore germination with abnormal germ tube morphology def: "A phenotype in which a spore germinates to produce a germ tube with abnormal size, shape, or structure." [PomBase:mah] synonym: "essential; germinating spore with abnormal germ tube morphology" RELATED [PomBase:mah] synonym: "inviable following spore germination with abnormal germ tube morphology" EXACT [PomBase:mah] synonym: "inviable germinated spore with abnormal germ tube morphology" EXACT [PomBase:mah] is_a: FYPO:0000316 ! inviable after spore germination is_a: FYPO:0002273 ! inviable vegetative cell with abnormal cell morphology created_by: midori creation_date: 2013-06-12T16:18:21Z [Term] id: FYPO:0002282 name: inviable curved septated vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is inviable, is curved along the long axis, and has one or more septa." [PomBase:mah] synonym: "essential; curved septated vegetative cell" RELATED [PomBase:mah] synonym: "inviable curved septated cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable curved septated vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0002113 ! inviable curved vegetative cell is_a: FYPO:0002452 ! inviable septated vegetative cell with abnormal cell morphology intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000016 ! curved vegetative cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0002342 ! septated vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000016 ! curved vegetative cell relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0002342 ! septated vegetative cell created_by: midori creation_date: 2013-06-12T16:30:43Z [Term] id: FYPO:0002283 name: abolished protein tyrosine phosphorylation during cellular response to heat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of tyrosine residues in one or more specific proteins, or of specific protein sites, does not occur during a cellular response to heat." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein tyrosine phosphorylation during cellular response to heat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein tyrosine phosphorylation during cellular response to heat during vegetative growth" EXACT [PomBase:mah] synonym: "abolished protein tyrosine phosphorylation during cellular response to heat shock" NARROW [PomBase:mah] synonym: "protein phosphorylation abolished during cellular response to heat" EXACT [PomBase:mah] is_a: FYPO:0002130 ! abolished protein phosphorylation during cellular response to heat is_a: FYPO:0002288 ! abolished protein tyrosine phosphorylation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0034605 ! cellular response to heat intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0018108 ! peptidyl-tyrosine phosphorylation relationship: during GO:0034605 ! cellular response to heat relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0018108 ! peptidyl-tyrosine phosphorylation created_by: midori creation_date: 2013-06-13T11:34:25Z [Term] id: FYPO:0002284 name: abolished protein tyrosine phosphorylation during cellular response to hydrogen peroxide def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of tyrosine residues in one or more specific proteins, or of specific protein sites, does not occur during a cellular response to hydrogen peroxide." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein tyrosine phosphorylation during cellular response to H2O2" EXACT [PomBase:mah] synonym: "abolished protein tyrosine phosphorylation during cellular response to hydrogen peroxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein tyrosine phosphorylation during cellular response to hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] synonym: "protein tyrosine phosphorylation abolished during cellular response to hydrogen peroxide" EXACT [PomBase:mah] is_a: FYPO:0002288 ! abolished protein tyrosine phosphorylation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0070301 ! cellular response to hydrogen peroxide intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0018108 ! peptidyl-tyrosine phosphorylation relationship: during GO:0070301 ! cellular response to hydrogen peroxide relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0018108 ! peptidyl-tyrosine phosphorylation created_by: midori creation_date: 2013-06-13T11:35:45Z [Term] id: FYPO:0002285 name: elongated cell during cellular response to hydrogen peroxide def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is elongated during a cellular response to hydrogen peroxide." [PomBase:mah] synonym: "elongated cell during cellular response to H2O2" EXACT [PomBase:mah] synonym: "elongated cell during cellular response to hydrogen peroxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "elongated cell during cellular response to hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] synonym: "elongated in response to hydrogen peroxide" EXACT [PomBase:al] is_a: FYPO:0001122 ! elongated vegetative cell intersection_of: FYPO:0000017 ! elongated cell intersection_of: exists_during GO:0070301 ! cellular response to hydrogen peroxide intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: exists_during GO:0070301 ! cellular response to hydrogen peroxide relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) created_by: midori creation_date: 2013-06-13T11:48:03Z [Term] id: FYPO:0002286 name: decreased RNA level during cellular response to osmotic stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to osmotic stress is lower than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "decreased mRNA level during cellular response to osmotic stress" NARROW [PomBase:mah] synonym: "decreased RNA level during cellular response to osmotic stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to osmotic stress during vegetative growth" EXACT [PomBase:mah] synonym: "decreased transcript level during cellular response to osmotic stress" EXACT [PomBase:vw] synonym: "reduced RNA level during cellular response to osmotic stress" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth is_a: FYPO:0003198 ! altered RNA level during cellular response to osmotic stress intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0071470 ! cellular response to osmotic stress intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0071470 ! cellular response to osmotic stress relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2013-06-13T13:09:14Z [Term] id: FYPO:0002287 name: decreased RNA level during cellular response to heat def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to heat is lower than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased RNA accumulation during cellular response to heat" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to heat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to heat during vegetative growth" EXACT [PomBase:mah] synonym: "decreased RNA level during cellular response to heat shock" NARROW [PomBase:mah] synonym: "decreased transcript level during cellular response to heat" EXACT [PomBase:vw] synonym: "reduced RNA level during cellular response to heat" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0034605 ! cellular response to heat intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0034605 ! cellular response to heat relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2013-06-13T13:13:48Z [Term] id: FYPO:0002288 name: abolished protein tyrosine phosphorylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of tyrosine residues in one or more specific proteins, or of specific protein sites, does not occur." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished peptidyl-tyrosine phosphorylation" EXACT [GO:0018108] synonym: "abolished protein tyrosine phosphorylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein tyrosine phosphorylation during vegetative growth" EXACT [PomBase:mah] synonym: "protein tyrosine phosphorylation abolished" EXACT [PomBase:mah] is_a: FYPO:0002033 ! abolished protein phosphorylation during vegetative growth intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0018108 ! peptidyl-tyrosine phosphorylation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0018108 ! peptidyl-tyrosine phosphorylation created_by: midori creation_date: 2013-06-13T13:37:19Z [Term] id: FYPO:0002289 name: abolished protein tyrosine phosphorylation during cellular response to osmotic stress def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of tyrosine residues in one or more specific proteins, or of specific protein sites, does not occur during a cellular response to osmotic stress." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein tyrosine phosphorylation during cellular response to osmotic stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein tyrosine phosphorylation during cellular response to osmotic stress during vegetative growth" EXACT [PomBase:mah] synonym: "protein tyrosine phosphorylation abolished during cellular response to osmotic stress" EXACT [PomBase:mah] is_a: FYPO:0002288 ! abolished protein tyrosine phosphorylation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0071470 ! cellular response to osmotic stress intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0018108 ! peptidyl-tyrosine phosphorylation relationship: during GO:0071470 ! cellular response to osmotic stress relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0018108 ! peptidyl-tyrosine phosphorylation created_by: midori creation_date: 2013-06-13T13:50:17Z [Term] id: FYPO:0002290 name: normal protein tyrosine phosphorylation during cellular response to osmotic stress def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of tyrosine residues of one or more specific proteins is normal during a cellular response to osmotic stress." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein tyrosine phosphorylation during cellular response to osmotic stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein tyrosine phosphorylation during cellular response to osmotic stress during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0004661 ! normal protein tyrosine phosphorylation during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0071470 ! cellular response to osmotic stress intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0018108 ! peptidyl-tyrosine phosphorylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0071470 ! cellular response to osmotic stress relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0018108 ! peptidyl-tyrosine phosphorylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-06-13T14:47:01Z [Term] id: FYPO:0002291 name: normal protein tyrosine phosphorylation during cellular response to heat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of tyrosine residues of one or more specific proteins is normal (i.e. indistinguishable from wild type) during a cellular response to heat." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein tyrosine phosphorylation during cellular response to heat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein tyrosine phosphorylation during cellular response to heat during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0004154 ! normal protein phosphorylation during cellular response to heat is_a: FYPO:0004661 ! normal protein tyrosine phosphorylation during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0034605 ! cellular response to heat intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0018108 ! peptidyl-tyrosine phosphorylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0034605 ! cellular response to heat relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0018108 ! peptidyl-tyrosine phosphorylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-06-13T14:47:56Z [Term] id: FYPO:0002292 name: viable tapered vegetative cell population def: "A cell population phenotype in which all cells in the population are viable and taper at one end to a diameter smaller than the other, in the vegetative growth phase of the life cycle." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. synonym: "population of tapered viable cells" EXACT [PomBase:vw] synonym: "viable bottle/skittle vegetative cell population" EXACT [PomBase:mah] synonym: "viable skittle-shaped vegetative cell population" EXACT [PomBase:mah] synonym: "viable vegetative cell population with skittle shaped cells" EXACT [PomBase:vw] is_obsolete: true replaced_by: FYPO:0002060 created_by: midori creation_date: 2013-06-13T14:56:49Z [Term] id: FYPO:0002293 name: viable mixed population including curved cells def: "A mixed population phenotype in which cells in the population are viable, and some cells are curved along the long axis." [PomBase:jh, PomBase:mah] comment: This term was made obsolete because a "mixed population" observation would be better represented as two or more separate phenotype annotations, each with penetrance specified. is_obsolete: true created_by: midori creation_date: 2013-06-13T15:02:16Z [Term] id: FYPO:0002294 name: inviable after spore germination with elongated germ tube and cell lysis def: "A phenotype in which a spore germinates to produce an elongated germ tube, but does not go on to form a viable dividing cell, and instead lyses." [PomBase:mah] synonym: "inviable after spore germination with elongated cell and cell lysis" EXACT [PomBase:mah] synonym: "inviable after spore germination, without cell division, with elongated germ tube and cell lysis" EXACT [PomBase:mah] synonym: "inviable germinated spore with elongated germ tube and cell lysis" EXACT [PomBase:mah] synonym: "lysed cell after spore germination with elongated germ tube" EXACT [PomBase:vw] is_a: FYPO:0002379 ! inviable after spore germination, without cell division, with elongated germ tube created_by: midori creation_date: 2013-06-13T15:12:40Z [Term] id: FYPO:0002295 name: mitotic catastrophe with cut, elongated cell during cellular response to hydroxyurea def: "An inviable phenotype in which a cell undergoes mitotic catastrophe (i.e. enters mitosis prematurely and with defective chromosome segregation), entering mitosis when longer than wild type, and then septates to give rise to a cut phenotype. In a cut phenotype, a cell undergoes septation despite abnormal chromosome segregation, such that the septum physically divides the nucleus into two parts, and produces inviable daughter cells." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: " mitotic catastrophe with cut, elongated cell during cellular response to HU" EXACT [PomBase:mah] synonym: "cut with mitotic catastrophe, elongated cell during cellular response to hydroxyurea" EXACT [PomBase:mah] synonym: "mitotic catastrophe with cut, elongated cell during cellular response to hydroxyurea during vegetative growth" EXACT [PomBase:mah] synonym: "mitotic catastrophe with cut, long cell" EXACT [PomBase:vw] is_a: FYPO:0001054 ! mitotic catastrophe with cut, elongated cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: happens_during GO:0072711 ! cellular response to hydroxyurea intersection_of: has_part FYPO:0000141 ! abnormal mitotic sister chromatid segregation intersection_of: has_part FYPO:0001204 ! mistimed mitosis intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0001490 ! inviable elongated vegetative cell intersection_of: has_part FYPO:0003165 ! cut relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: happens_during GO:0072711 ! cellular response to hydroxyurea relationship: has_part FYPO:0000141 ! abnormal mitotic sister chromatid segregation relationship: has_part FYPO:0001204 ! mistimed mitosis relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0001490 ! inviable elongated vegetative cell relationship: has_part FYPO:0003165 ! cut created_by: midori creation_date: 2013-06-13T15:21:02Z [Term] id: FYPO:0002296 name: cone-shaped colony morphology def: "A colony morphology phenotype in which the colony spreads laterally to a lesser extent, and grows vertically to a greater extent, resulting in a more conical shape, than a wild-type colony." [PomBase:jh, PomBase:mah] synonym: "piled-up colony morphology" EXACT [PomBase:jh, PomBase:vw] is_a: FYPO:0000150 ! abnormal colony morphology created_by: midori creation_date: 2013-06-13T15:37:00Z [Term] id: FYPO:0002297 name: dispersed actin cortical patch localization during mitotic interphase def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which actin cortical patches are localized throughout the cell cortex (rather than concentrated at the cell ends as in wild type cells) during interphase of the mitotic cell cycle." [PMID:8834798, PomBase:mah] synonym: "delocalised actin cortical patches during mitotic interphase" EXACT [PomBase:vw] synonym: "delocalized actin cortical patches during mitotic interphase" EXACT [PomBase:vw] synonym: "dispersed actin cortical patch localisation during mitotic interphase" EXACT [PomBase:mah] synonym: "dispersed actin cortical patch location during mitotic interphase" RELATED [PomBase:mah] is_a: FYPO:0002021 ! dispersed actin cortical patch localization intersection_of: PATO:0001630 ! dispersed intersection_of: exists_during GO:0051329 ! mitotic interphase intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0030479 ! actin cortical patch relationship: exists_during GO:0051329 ! mitotic interphase relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0030479 ! actin cortical patch created_by: midori creation_date: 2013-06-13T16:13:52Z [Term] id: FYPO:0002298 name: inviable mixed population including divided and undivided germinated spores, with elongated germ tubes def: "A mixed population phenotype in which all cells in a population are inviable germinated spores with elongated germ tubes, and in which some cells divide once and others do not divide. In the cells that divide once, an inviable cell forms from the growing end of the germ tube, but does not divide further." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because a "mixed population" observation would be better represented as two or more separate phenotype annotations, each with penetrance specified. synonym: "essential; mixed population including divided and undivided germinated spores, with elongated germ tubes" RELATED [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-06-20T11:41:51Z [Term] id: FYPO:0002299 name: inviable mixed population including divided and undivided germinated spores, with curved germ tubes def: "A mixed population phenotype in which all cells in a population are inviable germinated spores with curved germ tubes, and in which some cells divide once and others do not divide. In the cells that divide once, an inviable cell forms from the growing end of the germ tube, but does not divide further." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because a "mixed population" observation would be better represented as two or more separate phenotype annotations, each with penetrance specified. synonym: "essential; mixed population including divided and undivided germinated spores, with curved germ tubes" RELATED [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-06-20T11:44:24Z [Term] id: FYPO:0002300 name: inviable mixed population including germinated spores with elongated germ tubes and elongated cells def: "A mixed population phenotype in which all cells in a population are inviable, and the population includes a mixture of germinated spores with elongated germ tubes and elongated vegetative cells. The elongated cells arise from division of some of the germinated spores, and may form a microcolony of up to 64 cells." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because a "mixed population" observation would be better represented as two or more separate phenotype annotations, each with penetrance specified. synonym: "essential; mixed population including germinated spores with elongated germ tubes and elongated cells" RELATED [PomBase:mah] synonym: "inviable mixed population including germinated spores with elongated germ tubes and long cells" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-06-20T11:57:57Z [Term] id: FYPO:0002301 name: inviable microcolony, curved septated cells def: "A cell population phenotype in which a cell undergoes one or a few rounds of cell division before cells die, resulting in the formation a colony that contains only a few inviable cells that are curved along the long axis and contain one or more septa. Up to 6 rounds of cell division (generating 64 cells) may be observed, but 3 divisions or fewer is more typical." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype, with penetrance extensions where needed. synonym: "inviable microcolony, curved septated vegetative cells" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-06-20T13:28:56Z [Term] id: FYPO:0002302 name: inviable after spore germination, multiple cell divisions, spheroid cell def: "A phenotype in which a spore germinates to produce a cell that is spheroid, and undergoes two or more rounds of cell division and then dies." [PomBase:al, PomBase:mah] synonym: "essential; germinating spore, multiple cell divisions, spheroid cell" RELATED [PomBase:mah] synonym: "inviable after spore germination, multiple cell divisions, rounded cell" EXACT [PomBase:mah] synonym: "inviable following spore germination, multiple cell divisions, spheroid cell" EXACT [PomBase:mah] synonym: "inviable germinated spore, multiple cell divisions, spheroid cell" EXACT [PomBase:mah] is_a: FYPO:0002148 ! inviable after spore germination, multiple cell divisions, abnormal morphology created_by: midori creation_date: 2013-06-20T13:52:46Z [Term] id: FYPO:0002303 name: inviable mononucleate monoseptate vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is inviable, and has one nucleus and one septum." [PomBase:mah] synonym: "displaced nucleus with septum" RELATED [PMID:7798319] synonym: "inviable mononucleate monoseptate cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable mononucleate monoseptate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "septation in the absence of nuclear division" RELATED [PomBase:al, PomBase:vw] synonym: "septation independent of mitosis" RELATED [PomBase:al, PomBase:vw] synonym: "septation without nuclear division" RELATED [PomBase:al, PomBase:vw] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000060 ! mononucleate vegetative cell intersection_of: has_part FYPO:0001225 ! monoseptate intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000060 ! mononucleate vegetative cell relationship: has_part FYPO:0001225 ! monoseptate relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: output_of FYPO:0000229 ! septation following abnormal mitotic chromosome segregation created_by: midori creation_date: 2013-06-20T13:59:28Z [Term] id: FYPO:0002304 name: decreased RNA level during cellular response to salt stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to salt stress is lower than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased mRNA level during cellular response to salt stress" NARROW [PomBase:mah] synonym: "decreased RNA level during cellular response to salt stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to salt stress during vegetative growth" EXACT [PomBase:mah] synonym: "decreased transcript level during cellular response to salt stress" EXACT [PomBase:vw] synonym: "reduced RNA level during cellular response to salt stress" EXACT [PomBase:mah] is_a: FYPO:0002286 ! decreased RNA level during cellular response to osmotic stress intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0071472 ! cellular response to salt stress intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0071472 ! cellular response to salt stress relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2013-06-20T14:29:07Z [Term] id: FYPO:0002305 name: decreased RNA level during cellular response to non-ionic osmotic stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to non-ionic osmotic stress is lower than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased mRNA level during cellular response to non-ionic osmotic stress" NARROW [PomBase:mah] synonym: "decreased RNA level during cellular response to non-ionic osmotic stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to non-ionic osmotic stress during vegetative growth" EXACT [PomBase:mah] synonym: "decreased transcript level during cellular response to non-ionic osmotic stress" EXACT [PomBase:vw] synonym: "reduced RNA level during cellular response to non-ionic osmotic stress" EXACT [PomBase:mah] is_a: FYPO:0002286 ! decreased RNA level during cellular response to osmotic stress intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0071471 ! cellular response to non-ionic osmotic stress intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0071471 ! cellular response to non-ionic osmotic stress relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2013-06-20T14:30:30Z [Term] id: FYPO:0002306 name: abnormal 5-phosphoribose 1-diphosphate binding def: "A molecular function phenotype in which occurrence of 5-phosphoribose 1-diphosphate binding by a gene product (usually a protein) in a mutant is abnormal. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] comment: This term can mean that the mutated gene product itself binds 5-phosphoribose 1-diphosphate differently from wild type, or that a mutation in one gene affects 5-phosphoribose 1-diphosphate binding by a second gene product. When using this term, it is therefore recommended to note the specific protein(s) affected. synonym: "abnormal 5-O-phosphono-alpha-D-ribofuranosyl diphosphate binding" EXACT [CHEBI:17111] synonym: "abnormal phosphoribosylpyrophosphate binding" EXACT [PomBase:al] is_a: FYPO:0000707 ! abnormal molecular function is_a: FYPO:0001092 ! binding phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:1902248 ! 5-O-phosphono-alpha-D-ribofuranosyl diphosphate binding intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:1902248 ! 5-O-phosphono-alpha-D-ribofuranosyl diphosphate binding relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-06-20T15:05:41Z [Term] id: FYPO:0002307 name: increased 5-phosphoribose 1-diphosphate binding def: "A molecular function phenotype in which occurrence of 5-phosphoribose 1-diphosphate binding by a gene product (usually a protein) in a mutant is increased. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] comment: This term can mean that the mutated gene product itself binds 5-phosphoribose 1-diphosphate more than wild type, or that a mutation in one gene increases 5-phosphoribose 1-diphosphate binding by a second gene product. When using this term, it is therefore recommended to note the specific protein(s) affected. synonym: "increased 5-O-phosphono-alpha-D-ribofuranosyl diphosphate binding" EXACT [CHEBI:17111] synonym: "increased phosphoribosylpyrophosphate binding" EXACT [PomBase:al] is_a: FYPO:0002306 ! abnormal 5-phosphoribose 1-diphosphate binding is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:1902248 ! 5-O-phosphono-alpha-D-ribofuranosyl diphosphate binding relationship: inheres_in GO:1902248 ! 5-O-phosphono-alpha-D-ribofuranosyl diphosphate binding created_by: midori creation_date: 2013-06-20T15:05:50Z [Term] id: FYPO:0002308 name: abnormal IMP binding def: "A molecular function phenotype in which occurrence of IMP binding by a gene product (usually a protein) in a mutant is abnormal. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] is_a: FYPO:0000707 ! abnormal molecular function is_a: FYPO:0001092 ! binding phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:1902249 ! IMP binding intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:1902249 ! IMP binding relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-06-20T15:19:22Z [Term] id: FYPO:0002309 name: decreased IMP binding def: "A molecular function phenotype in which occurrence of IMP binding by a gene product (usually a protein) in a mutant is decreased. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "reduced IMP binding" EXACT [PomBase:mah] is_a: FYPO:0002308 ! abnormal IMP binding is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:1902249 ! IMP binding relationship: inheres_in GO:1902249 ! IMP binding created_by: midori creation_date: 2013-06-20T15:19:30Z [Term] id: FYPO:0002310 name: abnormal GMP binding def: "A molecular function phenotype in which occurrence of GMP binding by a gene product (usually a protein) in a mutant is abnormal. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] is_a: FYPO:0000707 ! abnormal molecular function is_a: FYPO:0001092 ! binding phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0019002 ! GMP binding intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0019002 ! GMP binding relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-06-20T15:19:22Z [Term] id: FYPO:0002311 name: decreased GMP binding def: "A molecular function phenotype in which occurrence of GMP binding by a gene product (usually a protein) in a mutant is decreased. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "reduced GMP binding" EXACT [PomBase:mah] is_a: FYPO:0002310 ! abnormal GMP binding is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0019002 ! GMP binding relationship: inheres_in GO:0019002 ! GMP binding created_by: midori creation_date: 2013-06-20T15:21:09Z [Term] id: FYPO:0002312 name: resistance to ionizing radiation during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which cells show decreased sensitivity to ionizing radiation." [PomBase:mah] synonym: "resistance to gamma irradiation during vegetative growth" NARROW [PomBase:mah] synonym: "resistance to gamma radiation during vegetative growth" NARROW [PomBase:mah] synonym: "resistance to ionizing radiation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistant to ionizing radiation during vegetative growth" EXACT [GO:0009414, PomBase:al] synonym: "resistant to IR during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000850 ! resistance to stress during vegetative growth created_by: midori creation_date: 2013-06-20T15:28:55Z [Term] id: FYPO:0002313 name: ergosterol absent from cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of ergosterol measured in a cell is too low to detect." [PomBase:mah] synonym: "ergosterol absent from cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "ergosterol absent from cell during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001208 ! substance absent from cell during vegetative growth is_a: FYPO:0002321 ! decreased cellular ergosterol level intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:16933 ! ergosterol relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:16933 ! ergosterol created_by: midori creation_date: 2013-06-21T14:32:23Z [Term] id: FYPO:0002314 name: GGPP absent from cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of all-trans-geranylgeranyl diphosphate (GGPP) measured in a cell is too low to detect." [PomBase:mah] synonym: "2-trans,6-trans,10-trans-geranylgeranyl diphosphate absent from cell" EXACT [CHEBI:48861] synonym: "all-trans-geranylgeranyl diphosphate absent from cell" EXACT [CHEBI:48861] synonym: "all-trans-geranylgeranyl pyrophosphate absent from cell" EXACT [CHEBI:48861] synonym: "GGPP absent from cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "GGPP absent from cell during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001208 ! substance absent from cell during vegetative growth is_a: FYPO:0002323 ! decreased cellular GGPP level intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:48861 ! 2-trans,6-trans,10-trans-geranylgeranyl diphosphate relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:48861 ! 2-trans,6-trans,10-trans-geranylgeranyl diphosphate created_by: midori creation_date: 2013-06-21T14:36:26Z [Term] id: FYPO:0002315 name: normal cellular FPP level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of all-trans-farnesyl diphosphate (FPP) measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular 2-trans,6-trans-farnesyl diphosphate level" EXACT [CHEBI:17407] synonym: "normal cellular farnesyl diphosphate level" BROAD [CHEBI:17407] synonym: "normal cellular farnesyl pyrophosphate level" BROAD [CHEBI:17407] synonym: "normal cellular FPP accumulation" RELATED [PomBase:mah] synonym: "normal cellular FPP level" EXACT [PomBase:mah] synonym: "normal cellular FPP level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular FPP level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001543 ! normal cellular phosphorus level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:17407 ! 2-trans,6-trans-farnesyl diphosphate relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:17407 ! 2-trans,6-trans-farnesyl diphosphate created_by: midori creation_date: 2013-06-21T14:40:55Z [Term] id: FYPO:0002316 name: normal cellular squalene level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of squalene measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular squalene accumulation" RELATED [PomBase:mah] synonym: "normal cellular squalene level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular squalene level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:15440 ! squalene relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:15440 ! squalene created_by: midori creation_date: 2013-06-21T14:47:33Z [Term] id: FYPO:0002317 name: increased cellular squalene level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of squalene measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular squalene level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular squalene level during vegetative growth" EXACT [PomBase:mah] synonym: "increased squalene accumulation" RELATED [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:15440 ! squalene relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:15440 ! squalene created_by: midori creation_date: 2013-06-21T14:48:26Z [Term] id: FYPO:0002318 name: increased cellular ergosterol level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of ergosterol measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular ergosterol level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular ergosterol level during vegetative growth" EXACT [PomBase:mah] synonym: "increased ergosterol accumulation" RELATED [PomBase:mah] is_a: FYPO:0002327 ! increased cellular sterol level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:16933 ! ergosterol relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:16933 ! ergosterol created_by: midori creation_date: 2013-06-21T14:49:08Z [Term] id: FYPO:0002319 name: increased cellular lanosterol level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of lanosterol measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular lanosterol level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular lanosterol level during vegetative growth" EXACT [PomBase:mah] synonym: "increased lanosterol accumulation" RELATED [PomBase:mah] is_a: FYPO:0002327 ! increased cellular sterol level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:16521 ! lanosterol relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:16521 ! lanosterol created_by: midori creation_date: 2013-06-21T14:49:57Z [Term] id: FYPO:0002320 name: decreased cellular squalene level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of squalene measured in a cell is lower than normal." [PomBase:mah] synonym: "decreased cellular squalene level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular squalene level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased squalene accumulation" RELATED [PomBase:al] synonym: "reduced cellular squalene level" EXACT [PomBase:mah] is_a: FYPO:0001329 ! decreased level of substance in cell during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:15440 ! squalene relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:15440 ! squalene created_by: midori creation_date: 2013-06-21T14:51:34Z [Term] id: FYPO:0002321 name: decreased cellular ergosterol level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of ergosterol measured in a cell is lower than normal." [PomBase:mah] synonym: "decreased cellular ergosterol level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular ergosterol level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased ergosterol accumulation" RELATED [PomBase:al] synonym: "reduced cellular ergosterol level" EXACT [PomBase:mah] is_a: FYPO:0002326 ! decreased cellular sterol level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:16933 ! ergosterol relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:16933 ! ergosterol created_by: midori creation_date: 2013-06-21T14:52:35Z [Term] id: FYPO:0002322 name: decreased cellular FPP level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of all-trans-farnesyl diphosphate (FPP) measured in a cell is lower than normal." [PomBase:mah] synonym: "decreased cellular 2-trans,6-trans-farnesyl diphosphate level" EXACT [CHEBI:17407] synonym: "decreased cellular farnesyl diphosphate level" BROAD [CHEBI:17407] synonym: "decreased cellular farnesyl pyrophosphate level" BROAD [CHEBI:17407] synonym: "decreased cellular FPP accumulation" RELATED [PomBase:mah] synonym: "decreased cellular FPP level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular FPP level during vegetative growth" EXACT [PomBase:mah] synonym: "reduced cellular FPP level" EXACT [PomBase:mah] is_a: FYPO:0001289 ! decreased phospholipid level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:17407 ! 2-trans,6-trans-farnesyl diphosphate relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:17407 ! 2-trans,6-trans-farnesyl diphosphate created_by: midori creation_date: 2013-06-21T14:53:46Z [Term] id: FYPO:0002323 name: decreased cellular GGPP level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of all-trans-geranylgeranyl diphosphate (GGPP) measured in a cell is lower than normal." [PomBase:mah] synonym: "decreased cellular 2-trans,6-trans,10-trans-geranylgeranyl diphosphate level" EXACT [CHEBI:48861] synonym: "decreased cellular all-trans-geranylgeranyl diphosphate level" EXACT [CHEBI:48861] synonym: "decreased cellular all-trans-geranylgeranyl pyrophosphate level" EXACT [CHEBI:48861] synonym: "decreased cellular GGPP level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular GGPP level during vegetative growth" EXACT [PomBase:mah] synonym: "reduced cellular GGPP level" EXACT [PomBase:mah] is_a: FYPO:0001289 ! decreased phospholipid level intersection_of: PATO:0001163 ! decreased concentration intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:48861 ! 2-trans,6-trans,10-trans-geranylgeranyl diphosphate relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:48861 ! 2-trans,6-trans,10-trans-geranylgeranyl diphosphate created_by: midori creation_date: 2013-06-21T14:55:28Z [Term] id: FYPO:0002324 name: decreased cellular lanosterol level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of lanosterol measured in a cell is lower than normal." [PomBase:mah] synonym: "decreased cellular lanosterol level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular lanosterol level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased ergosterol accumulation" RELATED [PomBase:al] synonym: "reduced cellular lanosterol level" EXACT [PomBase:mah] is_a: FYPO:0002326 ! decreased cellular sterol level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:16521 ! lanosterol relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:16521 ! lanosterol created_by: midori creation_date: 2013-06-21T15:03:47Z [Term] id: FYPO:0002325 name: altered cellular sterol level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of a sterol measured in a cell differs from normal. A sterol is any natural product derived from the steroid skeleton and containing a hydroxy group in the 3 position, closely related to cholestan-3-ol." [CHEBI:15889, PomBase:mah] synonym: "abnormal sterol level" EXACT [PomBase:mah] synonym: "altered cellular sterol level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "altered cellular sterol level during vegetative growth" EXACT [PomBase:mah] synonym: "altered sterol level" EXACT [PomBase:mah] is_a: FYPO:0001323 ! altered level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:15889 ! sterol relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:15889 ! sterol created_by: midori creation_date: 2013-06-21T15:04:32Z [Term] id: FYPO:0002326 name: decreased cellular sterol level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of a sterol measured in a cell is lower than normal. A sterol is any natural product derived from the steroid skeleton and containing a hydroxy group in the 3 position, closely related to cholestan-3-ol." [CHEBI:15889, PomBase:mah] synonym: "decreased cellular sterol level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular sterol level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased sterol level" EXACT [PomBase:mah] synonym: "reduced cellular sterol level" EXACT [PomBase:mah] is_a: FYPO:0001329 ! decreased level of substance in cell during vegetative growth is_a: FYPO:0002325 ! altered cellular sterol level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:15889 ! sterol relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:15889 ! sterol created_by: midori creation_date: 2013-06-21T15:06:49Z [Term] id: FYPO:0002327 name: increased cellular sterol level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of a sterol measured in a cell is higher than normal. A sterol is any natural product derived from the steroid skeleton and containing a hydroxy group in the 3 position, closely related to cholestan-3-ol." [CHEBI:15889, PomBase:mah] synonym: "increased cellular sterol level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular sterol level during vegetative growth" EXACT [PomBase:mah] synonym: "increased sterol level" EXACT [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth is_a: FYPO:0002325 ! altered cellular sterol level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:15889 ! sterol relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:15889 ! sterol created_by: midori creation_date: 2013-06-21T15:07:56Z [Term] id: FYPO:0002328 name: sensitive to terbinafine def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to terbinafine. Cells stop growing (and may die) at a concentration of terbinafine that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to terbinafine" EXACT [PomBase:mah] synonym: "sensitive to terbinafine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to terbinafine during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:9448 ! terbinafine relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:9448 ! terbinafine created_by: midori creation_date: 2013-06-21T15:16:32Z [Term] id: FYPO:0002329 name: normal growth on pravastatin def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing pravastatin." [PomBase:mah] synonym: "normal cell population growth in presence of pravastatin" EXACT [PomBase:mah] synonym: "normal cell population growth on pravastatin" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to pravastatin" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on pravastatin" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:63618 ! pravastatin relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:63618 ! pravastatin created_by: midori creation_date: 2013-06-21T15:18:15Z [Term] id: FYPO:0002330 name: abnormal histone H3-K4 methylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which methylation of lysine at position 4 of histone H3 is abnormal." [PomBase:mah] synonym: "abnormal histone H3 K4 methylation" EXACT [GO:0051568, PomBase:mah] synonym: "abnormal histone H3-K4 methylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal histone H3-K4 methylation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal histone H3K4me" EXACT [GO:0051568, PomBase:mah] synonym: "abnormal histone lysine H3 K4 methylation" EXACT [GO:0051568, PomBase:mah] is_a: FYPO:0000457 ! abnormal histone methylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0051568 ! histone H3-K4 methylation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0051568 ! histone H3-K4 methylation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-06-21T15:36:29Z [Term] id: FYPO:0002331 name: increased histone H3-K4 dimethylation at centromere outer repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the dimethylation of lysine at position 4 of histone H3 in centromere outer repeat regions occurs to a greater extent than normal." [PomBase:mah] synonym: "increased histone H3 K4 dimethylation at centromere outer repeat" EXACT [GO:0044648, PomBase:mah] synonym: "increased histone H3-K4 dimethylation at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H3-K4 dimethylation at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] synonym: "increased histone H3K4 dimethylation at centromere outer repeat" EXACT [PomBase:vw] synonym: "increased histone H3K4me2 at centromere outer repeat" EXACT [PomBase:mah] synonym: "increased histone lysine H3 K4 dimethylation at centromere outer repeat" EXACT [GO:0044648, PomBase:mah] is_a: FYPO:0000869 ! increased histone methylation is_a: FYPO:0002330 ! abnormal histone H3-K4 methylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0044648 ! histone H3-K4 dimethylation intersection_of: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0044648 ! histone H3-K4 dimethylation relationship: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region created_by: midori creation_date: 2013-06-21T17:31:19Z [Term] id: FYPO:0002332 name: normal protein localization to Golgi apparatus def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the Golgi apparatus is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to Golgi apparatus" EXACT [PomBase:mah] synonym: "normal protein localization to Golgi apparatus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to Golgi apparatus during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000644 ! normal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034067 ! protein localization to Golgi apparatus intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034067 ! protein localization to Golgi apparatus relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-07-05T15:54:40Z [Term] id: FYPO:0002333 name: protein localization phenotype def: "A cell phenotype that affects the localization of a protein in a cell." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "cellular protein localization phenotype" EXACT [GO:0034613] synonym: "fission yeast protein localization phenotype" EXACT [PomBase:mah] synonym: "protein localisation phenotype" EXACT [PomBase:mah] is_a: FYPO:0000138 ! localization phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: inheres_in_part_of GO:0034613 ! cellular protein localization relationship: inheres_in_part_of GO:0034613 ! cellular protein localization created_by: midori creation_date: 2013-07-05T15:59:48Z [Term] id: FYPO:0002334 name: haploproficient def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a diploid cell with a single functional copy of a gene grows faster than a diploid with two (on no) functional copies." [PMID:23531409, PomBase:mah] synonym: "haploproficient during mitotic cell cycle" RELATED [PomBase:mah] synonym: "haploproficient during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001320 ! vegetative cell phenotype is_a: FYPO:0003037 ! abnormal cell phenotype created_by: midori creation_date: 2013-07-05T16:12:09Z [Term] id: FYPO:0002335 name: normal chromatin silencing def: "A transcription regulation phenotype observed in the vegetative growth phase of the life cycle in which chromatin silencing is normal (i.e. indistinguishable from wild type). Chromatin silencing is repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into heterochromatin." [GO:0006342, PomBase:mah] synonym: "normal chromatin silencing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal chromatin silencing during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000578 ! normal gene silencing intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006342 ! chromatin silencing intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006342 ! chromatin silencing relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-07-09T13:52:25Z [Term] id: FYPO:0002336 name: normal chromatin silencing at silent mating-type cassette def: "A transcription regulation phenotype observed in the vegetative growth phase of the life cycle in which chromatin silencing at the silent mating-type cassettes is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal chromatin silencing at silent mating-type cassette during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal chromatin silencing at silent mating-type cassette during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002335 ! normal chromatin silencing intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0030466 ! chromatin silencing at silent mating-type cassette intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0030466 ! chromatin silencing at silent mating-type cassette relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-07-09T13:52:36Z [Term] id: FYPO:0002337 name: inviable elongated mononucleate vegetative cell with mislocalized nucleus def: "A cell phenotype in which a cell contains a single septum, has one nucleus that is not in the normal location, is elongated, and is inviable." [PomBase:mah, PomBase:vw] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "elongated inviable vegetative cell, with mislocalized mononucleus" EXACT [PomBase:vw] synonym: "inviable elongated mononucleate cell with abnormal nucleus location" EXACT [PomBase:mah] synonym: "inviable elongated mononucleate cell with abnormal nucleus position" EXACT [PomBase:mah] synonym: "inviable elongated mononucleate cell with displaced nucleus" EXACT [PomBase:mah] synonym: "inviable elongated mononucleate cell with mislocalised nucleus" EXACT [PomBase:mah] synonym: "inviable elongated mononucleate cell with mislocalized nucleus during vegetative growth" EXACT [PomBase:mah] synonym: "inviable elongated mononucleate cell with misplaced nucleus" EXACT [PomBase:mah] synonym: "inviable elongated mononucleate vegetative cell with mislocalized nucleus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable long mononucleate cell with mislocalized nucleus" EXACT [PomBase:vw] synonym: "inviable vegetative elongated mononucleate cell with mislocalized nucleus" EXACT [PomBase:mah] is_a: FYPO:0004255 ! inviable elongated mononucleate vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000060 ! mononucleate vegetative cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0002069 ! mislocalized nucleus relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000060 ! mononucleate vegetative cell relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0002069 ! mislocalized nucleus created_by: midori creation_date: 2013-07-09T14:14:25Z [Term] id: FYPO:0002338 name: abnormal protein localization to nuclear periphery def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nuclear periphery is abnormal. The nuclear periphery is the portion of the nuclear lumen proximal to the inner nuclear membrane." [PomBase:mah] comment: Encompasses both presence of proteins not normally found at the nuclear periphery and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to nuclear periphery" EXACT [PomBase:mah] synonym: "abnormal protein localization to nuclear periphery during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein localization to nuclear periphery during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001129 ! abnormal protein localization to nucleus during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1990139 ! protein localization to nuclear periphery intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1990139 ! protein localization to nuclear periphery relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-07-09T14:38:16Z [Term] id: FYPO:0002339 name: decreased protein localization to nuclear periphery def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nuclear periphery is decreased. The nuclear periphery is the portion of the nuclear lumen proximal to the inner nuclear membrane." [GO:0034399, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to nuclear periphery" EXACT [PomBase:mah] synonym: "decreased protein localization to nuclear periphery during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to nuclear periphery during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to nuclear periphery" EXACT [PomBase:mah] is_a: FYPO:0001514 ! decreased protein localization to nucleus during vegetative growth is_a: FYPO:0002338 ! abnormal protein localization to nuclear periphery intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990139 ! protein localization to nuclear periphery relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990139 ! protein localization to nuclear periphery created_by: midori creation_date: 2013-07-09T14:39:15Z [Term] id: FYPO:0002340 name: decreased DNA recombination during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of DNA recombination is decreased." [PomBase:mah] synonym: "decreased DNA recombination during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased DNA recombination frequency during vegetative growth" EXACT [PomBase:mah] synonym: "decreased DNA recombination rate during vegetative growth" RELATED [PomBase:mah] synonym: "decreased recombination during vegetative growth" EXACT [PomBase:vw] synonym: "reduced DNA recombination during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001345 ! abnormal DNA recombination during vegetative growth is_a: FYPO:0002712 ! decreased DNA recombination intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006310 ! DNA recombination relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006310 ! DNA recombination created_by: midori creation_date: 2013-07-09T15:19:36Z [Term] id: FYPO:0002341 name: increased duration of DNA damage checkpoint def: "A cell cycle checkpoint phenotype in which the duration of cell cycle arrest or delay due to regulation by any DNA damage checkpoint is greater than in wild type." [PomBase:mah] synonym: "delayed DNA damage checkpoint deactivation" EXACT [PomBase:mah] synonym: "prolonged DNA damage checkpoint" EXACT [PomBase:mah] is_a: FYPO:0000006 ! abnormal DNA damage checkpoint is_a: PATO:0000498 ! increased duration intersection_of: PATO:0000498 ! increased duration intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000077 ! DNA damage checkpoint relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000077 ! DNA damage checkpoint created_by: midori creation_date: 2013-07-09T15:43:06Z [Term] id: FYPO:0002342 name: septated vegetative cell def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the cell contains one or more septa." [PomBase:mah] synonym: "septated cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "septated cell during vegetative growth" EXACT [PomBase:mah] synonym: "septum present during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0004296 ! septated cell intersection_of: FYPO:0001321 ! cellular physical quality phenotype during vegetative growth intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000467 ! present intersection_of: towards GO:0000935 ! barrier septum relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000467 ! present relationship: towards GO:0000935 ! barrier septum created_by: midori creation_date: 2013-07-09T16:05:43Z [Term] id: FYPO:0002343 name: normal growth on terbinafine def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing terbinafine." [PomBase:mah] synonym: "normal cell population growth in presence of terbinafine" EXACT [PomBase:mah] synonym: "normal cell population growth on terbinafine" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to terbinafine" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on terbinafine" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:9448 ! terbinafine relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:9448 ! terbinafine created_by: midori creation_date: 2013-07-12T13:23:16Z [Term] id: FYPO:0002344 name: sensitive to phleomycin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity phleomycin. Cells stop growing (and may die) at a concentration of phleomycin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to phleomycin" EXACT [PomBase:mah] synonym: "sensitive to phleomycin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to phleomycin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:75044 ! phleomycin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:75044 ! phleomycin created_by: midori creation_date: 2013-07-12T14:33:03Z [Term] id: FYPO:0002345 name: sensitive to oxaliplatin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to oxaliplatin. Cells stop growing (and may die) at a concentration of oxaliplatin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to oxaliplatin" EXACT [PomBase:mah] synonym: "sensitive to oxaliplatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to oxaliplatin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:31941 ! oxaliplatin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:31941 ! oxaliplatin created_by: midori creation_date: 2013-07-12T14:43:28Z [Term] id: FYPO:0002346 name: abnormal chromatin silencing at centromere outer repeat def: "A transcription regulation phenotype observed in the vegetative growth phase of the life cycle in which chromatin silencing at the outer repeat region of the centromere is abnormal." [PomBase:mah] comment: Note that the centromere outer repeat region corresponds to SO:0001799. synonym: "abnormal centromere outer repeat region chromatin silencing" EXACT [PomBase:mah] synonym: "abnormal chromatin silencing at centromere otr" EXACT [PomBase:mah] synonym: "abnormal chromatin silencing at centromere outer repeat region" EXACT [GO:1990141] synonym: "abnormal chromatin silencing at centromere outer repeat region during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal chromatin silencing at centromere outer repeat region during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal chromatin silencing at centromeric outer repeat region" EXACT [PomBase:mah] synonym: "abnormal chromatin silencing at pericentric region" RELATED [PomBase:mah] synonym: "abnormal chromatin silencing at pericentromeric region" RELATED [PomBase:mah] synonym: "abnormal heterochromatic silencing at centromere outer repeat region" EXACT [PomBase:mah] synonym: "abnormal heterochromatin silencing at centromere outer repeat region" EXACT [PomBase:mah] is_a: FYPO:0000146 ! abnormal chromatin silencing at centromere intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1990141 ! chromatin silencing at centromere outer repeat region intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1990141 ! chromatin silencing at centromere outer repeat region relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-07-17T13:39:25Z [Term] id: FYPO:0002347 name: abnormal stress granule assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which stress granule assembly is abnormal." [PMID:21098141, PomBase:mah] synonym: "abnormal cytoplasmic stress granule assembly" EXACT [GO:0010494] synonym: "abnormal stress granule assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal stress granule assembly during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal stress granule formation" RELATED [PomBase:mah] is_a: FYPO:0003628 ! abnormal ribonucleoprotein complex assembly intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0034063 ! stress granule assembly intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0034063 ! stress granule assembly relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-07-17T13:46:11Z [Term] id: FYPO:0002348 name: abolished stress granule assembly def: "A cytokinesis phenotype observed in the vegetative growth phase of the life cycle in which stress granule assembly does not occur." [PMID:21098141, PomBase:mah] synonym: "abolished cytoplasmic stress granule assembly" EXACT [GO:0010494] synonym: "abolished stress granule assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished stress granule assembly during vegetative growth" EXACT [PomBase:mah] synonym: "abolished stress granule formation" RELATED [PomBase:mah] is_a: FYPO:0002347 ! abnormal stress granule assembly is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0034063 ! stress granule assembly relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0034063 ! stress granule assembly created_by: midori creation_date: 2013-07-17T13:46:22Z [Term] id: FYPO:0002349 name: delayed stress granule assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which stress granule assembly begins later than normal." [PMID:21098141, PomBase:mah] synonym: "delayed cytoplasmic stress granule assembly" EXACT [GO:0010494] synonym: "delayed stress granule assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "delayed stress granule assembly during vegetative growth" EXACT [PomBase:mah] synonym: "delayed stress granule formation" RELATED [PomBase:mah] is_a: FYPO:0002347 ! abnormal stress granule assembly is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034063 ! stress granule assembly relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034063 ! stress granule assembly created_by: midori creation_date: 2013-07-17T13:46:41Z [Term] id: FYPO:0002350 name: normal stress granule assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which stress granule assembly is normal (i.e. indistinguishable from wild type)." [PMID:21098141, PomBase:mah] synonym: "abnormal stress granule assembly during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal stress granule formation" RELATED [PomBase:mah] synonym: "normal cytoplasmic stress granule assembly" EXACT [GO:0010494] synonym: "normal stress granule assembly during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001319 ! normal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034063 ! stress granule assembly intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034063 ! stress granule assembly relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-07-17T13:47:03Z [Term] id: FYPO:0002351 name: abnormal stress granule disassembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which stress granule disassembly is abnormal." [PMID:21098141, PomBase:mah] synonym: "abnormal cytoplasmic stress granule disassembly" EXACT [GO:0010494] synonym: "abnormal stress granule disassembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal stress granule disassembly during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001354 ! abnormal cellular component assembly during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0035617 ! stress granule disassembly intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0035617 ! stress granule disassembly relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-07-17T13:54:28Z [Term] id: FYPO:0002352 name: delayed stress granule disassembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which stress granule disassembly begins later than normal." [PMID:21098141, PomBase:mah] synonym: "delayed cytoplasmic stress granule assembly" EXACT [GO:0010494] synonym: "delayed stress granule disassembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "delayed stress granule disassembly during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002351 ! abnormal stress granule disassembly is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0035617 ! stress granule disassembly relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0035617 ! stress granule disassembly created_by: midori creation_date: 2013-07-17T13:54:45Z [Term] id: FYPO:0002353 name: decreased chromatin silencing def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of chromatin silencing is decreased." [PomBase:mah] synonym: "decreased chromatin silencing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased chromatin silencing during vegetative growth" EXACT [PomBase:mah] synonym: "reduced chromatin silencing" EXACT [PomBase:mah] is_a: FYPO:0000144 ! abnormal chromatin silencing is_a: FYPO:0000576 ! decreased gene silencing intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006342 ! chromatin silencing relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006342 ! chromatin silencing created_by: midori creation_date: 2013-07-17T14:02:17Z [Term] id: FYPO:0002354 name: increased level of heterochromatin-encoded proteins def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein encoded by heterochromatic genes that are normally silenced is higher than normal." [PMID:22683269, PomBase:mah] is_a: FYPO:0001327 ! increased protein level during vegetative growth created_by: midori creation_date: 2013-07-17T14:51:57Z [Term] id: FYPO:0002355 name: decreased histone H3-K9 dimethylation at silent mating-type cassette def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the dimethylation of lysine at position 9 of histone H3 in silent mating-type cassettes occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased histone H3 K9 dimethylation at silent mating-type cassette" EXACT [GO:0036123, PomBase:mah] synonym: "decreased histone H3-K9 dimethylation at silent mating-type cassette during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H3-K9 dimethylation at silent mating-type cassette during vegetative growth" EXACT [PomBase:mah] synonym: "decreased histone H3K9 dimethylation at silent mating-type cassette" EXACT [PomBase:vw] synonym: "decreased histone H3K9me2 at silent mating-type cassette" EXACT [PomBase:mah] synonym: "decreased histone lysine H3 K9 dimethylation at silent mating-type cassette" EXACT [GO:0036123, PomBase:mah] synonym: "decreased silent mating-type cassette histone H3-K9 dimethylation" EXACT [PomBase:mah] synonym: "reduced histone H3-K9 dimethylation at silent mating-type cassette" EXACT [PomBase:mah] is_a: FYPO:0000876 ! decreased histone H3-K9 dimethylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0036123 ! histone H3-K9 dimethylation intersection_of: occurs_at SO:0001984 ! silent_mating_type_cassette_array relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0036123 ! histone H3-K9 dimethylation relationship: occurs_at SO:0001984 ! silent_mating_type_cassette_array created_by: midori creation_date: 2013-07-17T15:07:34Z [Term] id: FYPO:0002356 name: normal methylated histone residue binding def: "A molecular function phenotype in which occurrence of binding by a gene product to a methylated histone residue in a protein is normal (i.e. indistinguishable from wild type). The relevant proteins may include the one encoded by the mutated gene, or may both be encoded by different genes." [PomBase:mah] comment: This term can be used for any protein-protein interaction that is tested in a mutant, whether or not the mutated gene product is one of the interacting proteins. We recommend noting which proteins were used in the assay when annotating to this term. is_a: FYPO:0000703 ! normal protein binding intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0035064 ! methylated histone binding intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0035064 ! methylated histone binding relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-07-17T15:22:37Z [Term] id: FYPO:0002357 name: normal RNA binding def: "A molecular function phenotype in which occurrence of RNA binding by a gene product is normal (i.e. indistinguishable from wild type). The relevant gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] is_a: FYPO:0000706 ! normal molecular function is_a: FYPO:0002131 ! RNA binding phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0003723 ! RNA binding intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0003723 ! RNA binding relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-07-18T15:19:00Z [Term] id: FYPO:0002358 name: normal histone H3-K9 dimethylation at silent mating-type cassette def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the dimethylation of lysine at position 9 of histone H3 in silent mating-type cassettes is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal histone H3-K9 dimethylation at silent mating-type cassette during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal histone H3-K9 dimethylation at silent mating-type cassette during vegetative growth" EXACT [PomBase:mah] synonym: "normal histone H3K9me2 at silent mating-type cassette" EXACT [PomBase:mah] synonym: "normal silent mating-type cassette histone H3-K9 dimethylation " EXACT [PomBase:mah] is_a: FYPO:0000861 ! normal histone methylation created_by: midori creation_date: 2013-07-18T15:21:48Z [Term] id: FYPO:0002359 name: normal histone H3-K9 dimethylation at telomere def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the dimethylation of lysine at position 9 of histone H3 in telomeric regions is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal histone H3-K9 dimethylation at telomere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal histone H3-K9 dimethylation at telomere during vegetative growth" EXACT [PomBase:mah] synonym: "normal histone H3K9me2 at telomere" EXACT [PomBase:mah] synonym: "normal telomeric histone H3-K9 dimethylation " EXACT [PomBase:mah] is_a: FYPO:0000861 ! normal histone methylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0016571 ! histone methylation intersection_of: occurs_at SO:0000624 ! telomere intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0016571 ! histone methylation relationship: occurs_at SO:0000624 ! telomere relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-07-18T15:22:54Z [Term] id: FYPO:0002360 name: normal chromatin silencing at centromere def: "A transcription regulation phenotype observed in the vegetative growth phase of the life cycle in which chromatin silencing at centromeric regions is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal chromatin silencing at centromere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal chromatin silencing at centromere during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002335 ! normal chromatin silencing intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0030702 ! chromatin silencing at centromere intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0030702 ! chromatin silencing at centromere relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-07-18T15:28:31Z [Term] id: FYPO:0002361 name: abnormal histone H3 acetylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone H3 acetylation is abnormal." [PomBase:mah] synonym: "abnormal histone H3 acetylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal histone H3 acetylation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000456 ! abnormal histone acetylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0043966 ! histone H3 acetylation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0043966 ! histone H3 acetylation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-07-25T11:17:27Z [Term] id: FYPO:0002362 name: decreased histone H3 acetylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone H3 acetylation occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased histone H3 acetylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H3 acetylation during vegetative growth" EXACT [PomBase:mah] synonym: "reduced histone H3 acetylation" EXACT [PomBase:mah] is_a: FYPO:0000331 ! decreased histone acetylation is_a: FYPO:0002361 ! abnormal histone H3 acetylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0043966 ! histone H3 acetylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0043966 ! histone H3 acetylation created_by: midori creation_date: 2013-07-25T11:18:01Z [Term] id: FYPO:0002363 name: increased histone H3 acetylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone H3 acetylation occurs to a greater extent than normal." [PomBase:mah] synonym: "increased histone H3 acetylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H3 acetylation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000332 ! increased histone acetylation is_a: FYPO:0002361 ! abnormal histone H3 acetylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0043966 ! histone H3 acetylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0043966 ! histone H3 acetylation created_by: midori creation_date: 2013-07-25T11:18:14Z [Term] id: FYPO:0002364 name: abnormal histone H4 acetylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone H4 acetylation is abnormal." [PomBase:mah] synonym: "abnormal histone H4 acetylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal histone H4 acetylation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000456 ! abnormal histone acetylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0043967 ! histone H4 acetylation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0043967 ! histone H4 acetylation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-07-25T11:27:40Z [Term] id: FYPO:0002365 name: increased histone H4 acetylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone H4 acetylation occurs to a greater extent than normal." [PomBase:mah] synonym: "increased histone H4 acetylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H4 acetylation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000332 ! increased histone acetylation is_a: FYPO:0002364 ! abnormal histone H4 acetylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0043967 ! histone H4 acetylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0043967 ! histone H4 acetylation created_by: midori creation_date: 2013-07-25T11:27:49Z [Term] id: FYPO:0002366 name: decreased histone H3-K4 methylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which methylation of lysine at position 4 of histone H3 occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased histone H3 K4 methylation" EXACT [GO:0051568, PomBase:mah] synonym: "decreased histone H3-K4 methylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H3-K4 methylation during vegetative growth" EXACT [PomBase:mah] synonym: "decreased histone H3K4me" EXACT [GO:0051568, PomBase:mah] synonym: "decreased histone lysine H3 K4 methylation" EXACT [GO:0051568, PomBase:mah] synonym: "reduced histone H3-K4 methylation" EXACT [PomBase:mah] is_a: FYPO:0000870 ! decreased histone methylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051568 ! histone H3-K4 methylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051568 ! histone H3-K4 methylation created_by: midori creation_date: 2013-07-25T12:16:12Z [Term] id: FYPO:0002367 name: decreased histone H3-K4 dimethylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which dimethylation of lysine at position 4 of histone H3 occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased histone H3 K4 dimethylation" EXACT [GO:0044648, PomBase:mah] synonym: "decreased histone H3-K4 dimethylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H3-K4 dimethylation during vegetative growth" EXACT [PomBase:mah] synonym: "decreased histone H3K4 dimethylation" EXACT [PomBase:vw] synonym: "decreased histone H3K4me2" EXACT [PomBase:mah] synonym: "decreased histone lysine H3 K4 dimethylation" EXACT [GO:0044648, PomBase:mah] synonym: "reduced histone H3-K4 dimethylation" EXACT [PomBase:mah] is_a: FYPO:0002366 ! decreased histone H3-K4 methylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0044648 ! histone H3-K4 dimethylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0044648 ! histone H3-K4 dimethylation created_by: midori creation_date: 2013-07-25T12:16:23Z [Term] id: FYPO:0002368 name: decreased histone H3-K4 trimethylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which trimethylation of lysine at position 4 of histone H3 occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased histone H3 K4 trimethylation" EXACT [GO:0080182, PomBase:mah] synonym: "decreased histone H3-K4 trimethylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H3-K4 trimethylation during vegetative growth" EXACT [PomBase:mah] synonym: "decreased histone H3K4 trimethylation" EXACT [PomBase:vw] synonym: "decreased histone H3K4me3" EXACT [PomBase:mah] synonym: "decreased histone lysine H3 K4 trimethylation" EXACT [GO:0080182, PomBase:mah] synonym: "reduced histone H3-K4 trimethylation" EXACT [PomBase:mah] is_a: FYPO:0002366 ! decreased histone H3-K4 methylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0080182 ! histone H3-K4 trimethylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0080182 ! histone H3-K4 trimethylation created_by: midori creation_date: 2013-07-25T12:16:39Z [Term] id: FYPO:0002369 name: increased histone H3-K56 acetylation at centromere outer repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which acetylation of lysine at position 56 of histone H3 in centromere outer repeat regions occurs to a greater extent than normal." [PomBase:mah] synonym: "abnormal histone H3-K56 acetylation at centromere otr" EXACT [PomBase:mah] synonym: "abnormal histone H3-K56 acetylation at centromeric outer repeat region" EXACT [PomBase:mah] synonym: "abnormal histone H3-K56 acetylation at pericentric region" RELATED [PomBase:mah] synonym: "abnormal histone H3-K56 acetylation at pericentromeric region" RELATED [PomBase:mah] synonym: "increased histone H3-K56 acetylation at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H3-K56 acetylation at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] synonym: "increased histone H3K56 acetylation at centromere outer repeat" EXACT [GO:0097043, PomBase:vw] is_a: FYPO:0002381 ! increased histone H3 acetylation at centromere outer repeat intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0097043 ! histone H3-K56 acetylation intersection_of: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0097043 ! histone H3-K56 acetylation relationship: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region created_by: midori creation_date: 2013-07-25T12:41:15Z [Term] id: FYPO:0002370 name: increased histone H3-K56 acetylation in transcribed regions def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which acetylation of lysine at position 56 of histone H3 in regions of the genome that are actively transcribed occurs to a greater extent than normal." [PMID:23851719, PomBase:mah] synonym: "increased histone H3-K56 acetylation in transcribed regions during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H3-K56 acetylation in transcribed regions during vegetative growth" EXACT [PomBase:mah] synonym: "increased histone H3K56 acetylation in transcribed regions" EXACT [GO:0097043, PomBase:vw] is_a: FYPO:0002363 ! increased histone H3 acetylation created_by: midori creation_date: 2013-07-25T12:43:03Z [Term] id: FYPO:0002371 name: inviable mixed population including spores, undivided germinated spores and divided germinated spores def: "A mixed population phenotype in which all cells in a population are inviable, and the population includes a mixture of spores, undivided germinated spores, and germinated spores that go on to divide once or twice. Some germinated spores remain septated and do not complete cell division." [PomBase:jh, PomBase:mah] comment: This term was made obsolete because a "mixed population" observation would be better represented as two or more separate phenotype annotations, each with penetrance specified. synonym: "essential; mixed population including spores in divided germinated spores, and divided germinated spores" RELATED [PomBase:mah] synonym: "inviable mixed population including spores and undivided and divided germinated spores" EXACT [PomBase:vw] is_obsolete: true created_by: midori creation_date: 2013-07-25T13:32:16Z [Term] id: FYPO:0002372 name: viable spheroid vegetative cell population def: "A cell population phenotype in which all cells in the population are viable and are shaped in the form of spheroids." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. synonym: "population of spheroid viable cells" EXACT [PomBase:vw] synonym: "viable rounded vegetative cell population" EXACT [PomBase:mah] is_obsolete: true replaced_by: FYPO:0002060 created_by: midori creation_date: 2013-07-25T13:38:18Z [Term] id: FYPO:0002373 name: abnormal actin cortical patch localization during mitosis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which actin cortical patch localization is abnormal during mitosis." [PomBase:mah] synonym: "abnormal actin cortical patch localisation during mitosis" EXACT [PomBase:mah] synonym: "abnormal actin cortical patch localization during mitosis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal actin cortical patch localization during mitosis during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal actin cortical patch localization during mitotic M phase" EXACT [PomBase:mah] synonym: "abnormal actin cortical patch localization during mitotic nuclear division" EXACT [GO:0007067] synonym: "abnormal actin cortical patch location during mitosis" RELATED [PomBase:mah] synonym: "abnormal actin patch localization during mitosis" EXACT [PomBase:vw] is_a: FYPO:0000190 ! abnormal actin cortical patch localization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0007067 ! mitotic nuclear division intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0051666 ! actin cortical patch localization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0007067 ! mitotic nuclear division relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0051666 ! actin cortical patch localization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-07-25T13:44:30Z [Term] id: FYPO:0002374 name: abnormal actin cortical patch morphology during mitosis def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of actin cortical patches is abnormal during mitosis." [PomBase:mah] synonym: "abnormal actin cortical patch morphology during mitosis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal actin cortical patch morphology during mitosis during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal actin cortical patch morphology during mitotic M phase" EXACT [PomBase:mah] synonym: "abnormal actin cortical patch morphology during mitotic nuclear division" EXACT [GO:0007067] is_a: FYPO:0000791 ! abnormal actin cortical patch morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0007067 ! mitotic nuclear division intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0030479 ! actin cortical patch intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0007067 ! mitotic nuclear division relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0030479 ! actin cortical patch relationship: output_of FYPO:0000790 ! abnormal actin cortical patch organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-07-25T13:46:11Z [Term] id: FYPO:0002375 name: decreased protein tyrosine phosphorylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of tyrosine residues in one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased peptidyl-tyrosine phosphorylation" EXACT [GO:0018108, PomBase:mah] synonym: "decreased protein tyrosine phosphorylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein tyrosine phosphorylation during vegetative growth" EXACT [PomBase:mah] synonym: "decreased tyrosine phosphorylation" EXACT [PomBase:al] synonym: "reduced protein tyrosine phosphorylation" EXACT [PomBase:mah] is_a: FYPO:0001838 ! decreased protein phosphorylation during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0018108 ! peptidyl-tyrosine phosphorylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0018108 ! peptidyl-tyrosine phosphorylation created_by: midori creation_date: 2013-07-25T14:54:57Z [Term] id: FYPO:0002376 name: decreased protein tyrosine phosphorylation during cellular response to osmotic stress def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of tyrosine residues in one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal during a cellular response to osmotic stress." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased peptidyl-tyrosine phosphorylation during cellular response to osmotic stress" EXACT [GO:0018108, PomBase:mah] synonym: "decreased protein tyrosine phosphorylation during cellular response to osmotic stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein tyrosine phosphorylation during cellular response to osmotic stress during vegetative growth" EXACT [PomBase:mah] synonym: "decreased tyrosine phosphorylation during cellular response to osmotic stress" EXACT [PomBase:al] synonym: "reduced protein tyrosine phosphorylation during cellular response to osmotic stress" EXACT [PomBase:mah] is_a: FYPO:0002375 ! decreased protein tyrosine phosphorylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0071470 ! cellular response to osmotic stress intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0018108 ! peptidyl-tyrosine phosphorylation relationship: happens_during GO:0071470 ! cellular response to osmotic stress relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0018108 ! peptidyl-tyrosine phosphorylation created_by: midori creation_date: 2013-07-25T14:56:04Z [Term] id: FYPO:0002377 name: viable swollen vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is viable and has a larger volume than normal. In a swollen cell, both length and diameter are greater than normal, although the cell is only considered elongated if the length:width ratio is also greater than normal." [PomBase:mah] synonym: "viable enlarged vegetative cell" RELATED [PomBase:mah] synonym: "viable large vegetative cell" RELATED [PomBase:vw] synonym: "viable swollen cell during vegetative growth" EXACT [PomBase:mah] synonym: "viable swollen vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "viable vegetative cell with increased cell size" RELATED [PomBase:vw] synonym: "viable vegetative cell with increased cell volume" EXACT [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000025 ! swollen cell intersection_of: has_part FYPO:0001491 ! viable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000025 ! swollen cell relationship: has_part FYPO:0001491 ! viable vegetative cell created_by: midori creation_date: 2013-07-25T14:59:46Z [Term] id: FYPO:0002378 name: viable swollen vegetative cell population def: "A cell population phenotype in which all cells in the population are viable but have a greater length, diameter, and volume than normal in the vegetative growth phase of the life cycle." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. synonym: "viable enlarged vegetative cell population" RELATED [PomBase:mah] synonym: "viable large vegetative cell population" RELATED [PomBase:vw] synonym: "viable vegetative cell population with increased cell size" RELATED [PomBase:vw] synonym: "viable vegetative cell population with increased cell volume" EXACT [PomBase:mah] is_obsolete: true replaced_by: FYPO:0002060 created_by: midori creation_date: 2013-07-25T15:02:36Z [Term] id: FYPO:0002379 name: inviable after spore germination, without cell division, with elongated germ tube def: "A phenotype in which a spore germinates to produce an elongated germ tube, but does not go on to form a viable dividing cell." [PomBase:mah] synonym: "inviable after spore germination, without cell division, elongated cell" EXACT [PomBase:mah] synonym: "inviable germinated spore, without cell division, with elongated germ tube" EXACT [PomBase:mah] is_a: FYPO:0000313 ! inviable after spore germination, without cell division, with abnormal germ tube morphology is_a: FYPO:0000314 ! inviable after spore germination with elongated germ tube is_a: FYPO:0004603 ! inviable after spore germination, without cell division, elongated cell created_by: midori creation_date: 2013-07-25T15:18:21Z [Term] id: FYPO:0002380 name: viable spheroid vegetative cell def: "A cell morphology phenotype in which a vegetatively growing cell is viable, and shaped in the form of a spheroid. In spheroid cells, there is much less difference between the long and short axes of the cell than in wild type. Spheroid cells may shorter than normal, with approximately the same diameter as normal, or they may be enlarged." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "spheroid viable cell" EXACT [PomBase:mah] synonym: "viable round vegetative cell" RELATED [PomBase:mah] synonym: "viable rounded vegetative cell" EXACT [PomBase:mah] synonym: "viable spheroid cell" EXACT [PomBase:mah] synonym: "viable spheroid cell during vegetative growth" EXACT [PomBase:mah] synonym: "viable spheroid vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0002197 ! viable vegetative cell with abnormal cell shape intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000021 ! spheroid vegetative cell intersection_of: has_part FYPO:0001491 ! viable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000021 ! spheroid vegetative cell relationship: has_part FYPO:0001491 ! viable vegetative cell created_by: midori creation_date: 2013-07-25T16:27:44Z [Term] id: FYPO:0002381 name: increased histone H3 acetylation at centromere outer repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone H3 acetylation occurs to a greater extent than normal in centromere outer repeat regions." [PomBase:mah] synonym: "abnormal histone H3 acetylation at centromere otr" EXACT [PomBase:mah] synonym: "abnormal histone H3 acetylation at centromeric outer repeat region" EXACT [PomBase:mah] synonym: "abnormal histone H3 acetylation at pericentric region" RELATED [PomBase:mah] synonym: "abnormal histone H3 acetylation at pericentromeric region" RELATED [PomBase:mah] synonym: "increased histone H3 acetylation at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H3 acetylation at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002363 ! increased histone H3 acetylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0043966 ! histone H3 acetylation intersection_of: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0043966 ! histone H3 acetylation relationship: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region created_by: midori creation_date: 2013-07-30T12:21:23Z [Term] id: FYPO:0002382 name: increased histone H4 acetylation at centromere outer repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone H4 acetylation occurs to a greater extent than normal in centromere outer repeat regions." [PomBase:mah] synonym: "abnormal histone H4 acetylation at centromere otr" EXACT [PomBase:mah] synonym: "abnormal histone H4 acetylation at centromeric outer repeat region" EXACT [PomBase:mah] synonym: "abnormal histone H4 acetylation at pericentric region" RELATED [PomBase:mah] synonym: "abnormal histone H4 acetylation at pericentromeric region" RELATED [PomBase:mah] synonym: "increased histone H4 acetylation at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H4 acetylation at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002365 ! increased histone H4 acetylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0043967 ! histone H4 acetylation intersection_of: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0043967 ! histone H4 acetylation relationship: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region created_by: midori creation_date: 2013-07-30T12:23:26Z [Term] id: FYPO:0002383 name: increased histone H3-K9 and H3-K14 acetylation at centromere outer repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which acetylation of lysine at positions 9 and 14 of histone H3 in regions of the genome that are actively transcribed occurs to a greater extent than normal." [PMID:23851719, PomBase:mah] comment: Modifications detected by antibody (see http://www.millipore.com/coa.nsf/a73664f9f981af8c852569b9005b4eee/51ec49cf6807c0598525730600548fc0/$FILE/06-599-17300.pdf). synonym: "abnormal histone H3-K9 and H3-K14 acetylation at centromere otr" EXACT [PomBase:mah] synonym: "abnormal histone H3-K9 and H3-K14 acetylation at centromeric outer repeat region" EXACT [PomBase:mah] synonym: "abnormal histone H3-K9 and H3-K14 acetylation at pericentric region" RELATED [PomBase:mah] synonym: "abnormal histone H3-K9 and H3-K14 acetylation at pericentromeric region" RELATED [PomBase:mah] synonym: "increased histone H3 acetylation (K9 and K14) at centromere outer repeat" EXACT [PMID:23851719] synonym: "increased histone H3-K9 and H3-K14 acetylation at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H3-K9 and H3-K14 acetylation at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] synonym: "increased histone H3K9 and H3K14 acetylation at centromere outer repeat" EXACT [PomBase:mah] is_a: FYPO:0002381 ! increased histone H3 acetylation at centromere outer repeat created_by: midori creation_date: 2013-07-30T12:39:07Z [Term] id: FYPO:0002384 name: increased histone H4-K5, H4-K8, H4-K12 and H4-K16 acetylation at centromere outer repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which acetylation of lysine at positions 5, 8, 12 and 16 of histone H4 in at centromere outer repeat regions occurs to a greater extent than normal." [PMID:23851719, PomBase:mah] comment: Modifications detected by antibody (see http://www.millipore.com/coa.nsf/a73664f9f981af8c852569b9005b4eee/aa10134d44ac430a8525730600550ec4/$FILE/06-866-19336.pdf). synonym: "increased histone H4 acetylation (K5, K8, K12 and K16) at centromere outer repeat" EXACT [PMID:23851719] synonym: "increased histone H4-K5, H4-K8, H4-K12 and H4-K16 acetylation at centromere otr" EXACT [PomBase:mah] synonym: "increased histone H4-K5, H4-K8, H4-K12 and H4-K16 acetylation at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H4-K5, H4-K8, H4-K12 and H4-K16 acetylation at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] synonym: "increased histone H4-K5, H4-K8, H4-K12 and H4-K16 acetylation at centromeric outer repeat region" EXACT [PomBase:mah] synonym: "increased histone H4-K5, H4-K8, H4-K12 and H4-K16 acetylation at pericentric region" RELATED [PomBase:mah] synonym: "increased histone H4-K5, H4-K8, H4-K12 and H4-K16 acetylation at pericentromeric region" RELATED [PomBase:mah] synonym: "increased histone H4K5, H4K8, H4K12 and H4K16 acetylation at centromere outer repeat" EXACT [PomBase:mah] is_a: FYPO:0000332 ! increased histone acetylation created_by: midori creation_date: 2013-07-30T12:44:38Z [Term] id: FYPO:0002385 name: decreased protein localization to heterochromatin during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to heterochromatin is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to heterochromatin during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein localization to heterochromatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "reduced protein localization to heterochromatin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001131 ! abnormal protein localization to heterochromatin during vegetative growth is_a: FYPO:0002909 ! decreased protein localization to chromatin during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0097355 ! protein localization to heterochromatin relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0097355 ! protein localization to heterochromatin created_by: midori creation_date: 2013-07-30T14:48:45Z [Term] id: FYPO:0002386 name: decreased protein localization to heterochromatin at centromere outer repeat def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to heterochromatin at centromere outer repeat regions is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "deceased protein localization to heterochromatin at centromere otr" EXACT [PomBase:mah] synonym: "decreased protein localisation to heterochromatin at centromere outer repeat" EXACT [PomBase:mah] synonym: "decreased protein localization to centromere outer repeat heterochromatin" EXACT [PomBase:mah] synonym: "decreased protein localization to heterochromatin at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to heterochromatin at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein localization to heterochromatin at centromeric outer repeat region" EXACT [PomBase:mah] synonym: "decreased protein localization to heterochromatin at pericentric region" RELATED [PomBase:mah] synonym: "decreased protein localization to heterochromatin at pericentromeric region" RELATED [PomBase:mah] synonym: "reduced protein localization to heterochromatin at centromere outer repeat" EXACT [PomBase:mah] is_a: FYPO:0002385 ! decreased protein localization to heterochromatin during vegetative growth is_a: FYPO:0002842 ! decreased protein localization to centromere outer repeat intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0097355 ! protein localization to heterochromatin intersection_of: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0097355 ! protein localization to heterochromatin relationship: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region created_by: midori creation_date: 2013-07-30T14:55:26Z [Term] id: FYPO:0002387 name: decreased protein localization to telomeric heterochromatin during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to heterochromatin at telomeres is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to heterochromatin at telomere during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein localization to heterochromatin at telomere during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein localization to telomeric heterochromatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to telomeric heterochromatin during vegetative growth" EXACT [PomBase:al] synonym: "reduced protein localization to heterochromatin at telomere during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002385 ! decreased protein localization to heterochromatin during vegetative growth is_a: FYPO:0003803 ! decreased protein localization to telomere intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990152 ! protein localization to telomeric heterochromatin relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990152 ! protein localization to telomeric heterochromatin created_by: midori creation_date: 2013-07-30T14:57:37Z [Term] id: FYPO:0002388 name: abnormal riboflavin binding def: "A molecular function phenotype in which occurrence of riboflavin binding by a gene product (usually a protein) in a mutant is abnormal. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] is_a: FYPO:0000707 ! abnormal molecular function is_a: FYPO:0001092 ! binding phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:1902444 ! riboflavin binding intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:1902444 ! riboflavin binding relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-10-16T11:29:35Z [Term] id: FYPO:0002389 name: normal protein localization to heterochromatin at centromere outer repeat def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to heterochromatin at centromere outer repeat regions is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to heterochromatin at centromere outer repeat" EXACT [PomBase:mah] synonym: "normal protein localization at centromere otr" EXACT [PomBase:mah] synonym: "normal protein localization at centromeric outer repeat region" EXACT [PomBase:mah] synonym: "normal protein localization at pericentric region" RELATED [PomBase:mah] synonym: "normal protein localization at pericentromeric region" RELATED [PomBase:mah] synonym: "normal protein localization to centromere outer repeat heterochromatin" EXACT [PomBase:mah] synonym: "normal protein localization to heterochromatin at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to heterochromatin at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001509 ! normal protein localization to chromatin intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0097355 ! protein localization to heterochromatin intersection_of: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0097355 ! protein localization to heterochromatin relationship: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-07-30T15:02:49Z [Term] id: FYPO:0002390 name: normal mitotic sister chromatid cohesion def: "A cellular process phenotype in which mitotic sister chromatid cohesion is normal (i.e. indistinguishable from wild type). Mitotic sister chromatid cohesion is the process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle." [GO:0007064, PomBase:mah] synonym: "normal mitotic chromosome cohesion" EXACT [PomBase:mah] synonym: "normal mitotic sister chromatid cohesion during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002741 ! normal mitotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0007064 ! mitotic sister chromatid cohesion intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0007064 ! mitotic sister chromatid cohesion relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-07-30T15:06:33Z [Term] id: FYPO:0002391 name: decreased protein localization to rDNA def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to parts of the chromosome containing ribosomal DNA is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to rDNA" EXACT [PomBase:mah] synonym: "decreased protein localization to rDNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to rDNA during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein localization to ribosomal DNA" EXACT [PomBase:mah] synonym: "reduced protein localization to rDNA" EXACT [PomBase:mah] is_a: FYPO:0000443 ! abnormal protein localization during vegetative growth created_by: midori creation_date: 2013-07-30T15:08:19Z [Term] id: FYPO:0002392 name: abnormal protein acetylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the acetylation of one or more specific proteins is abnormal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein acetylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein acetylation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000329 ! abnormal protein modification during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006473 ! protein acetylation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006473 ! protein acetylation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-07-30T15:31:06Z [Term] id: FYPO:0002393 name: abolished protein acetylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the acetylation of one or more specific proteins, or of specific protein sites, does not occur." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein acetylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein acetylation during vegetative growth" EXACT [PomBase:mah] synonym: "protein acetylation abolished" EXACT [PomBase:mah] synonym: "protein acetylation absent" EXACT [PomBase:al] is_a: FYPO:0000544 ! abolished protein modification during vegetative growth is_a: FYPO:0002392 ! abnormal protein acetylation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0006473 ! protein acetylation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0006473 ! protein acetylation created_by: midori creation_date: 2013-07-30T15:31:44Z [Term] id: FYPO:0002394 name: decreased protein acetylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the acetylation of one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein acetylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein acetylation during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein acetylation" EXACT [PomBase:mah] is_a: FYPO:0000545 ! decreased protein modification during vegetative growth is_a: FYPO:0002392 ! abnormal protein acetylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006473 ! protein acetylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006473 ! protein acetylation created_by: midori creation_date: 2013-07-30T15:32:01Z [Term] id: FYPO:0002395 name: decreased maintenance of protein localization to heterochromatin at centromere outer repeat def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the maintenance of localization of a protein at a location in heterochromatin at centromere outer repeat regions is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal maintenance of protein localization to heterochromatin at centromere otr" EXACT [PomBase:mah] synonym: "abnormal maintenance of protein localization to heterochromatin at centromeric outer repeat region" EXACT [PomBase:mah] synonym: "abnormal maintenance of protein localization to heterochromatin at pericentric region" RELATED [PomBase:mah] synonym: "abnormal maintenance of protein localization to heterochromatin at pericentromeric region" RELATED [PomBase:mah] synonym: "decreased maintenance of protein localisation to heterochromatin at centromere outer repeat" EXACT [PomBase:mah] synonym: "decreased maintenance of protein localization to centromere outer repeat heterochromatin" EXACT [PomBase:mah] synonym: "decreased maintenance of protein localization to heterochromatin at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased maintenance of protein localization to heterochromatin at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] synonym: "reduced maintenance of protein localization to heterochromatin at centromere outer repeat" EXACT [PomBase:mah] is_a: FYPO:0002386 ! decreased protein localization to heterochromatin at centromere outer repeat intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990153 ! maintenance of protein localization to heterochromatin intersection_of: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990153 ! maintenance of protein localization to heterochromatin relationship: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region created_by: midori creation_date: 2013-07-30T15:38:11Z [Term] id: FYPO:0002396 name: normal maintenance of protein localization to heterochromatin at centromere outer repeat def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the maintenance of localization of a protein at a location in heterochromatin at centromere outer repeat regions is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal maintenance of protein localisation to heterochromatin at centromere outer repeat" EXACT [PomBase:mah] synonym: "normal maintenance of protein localization to centromere outer repeat heterochromatin" EXACT [PomBase:mah] synonym: "normal maintenance of protein localization to heterochromatin at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal maintenance of protein localization to heterochromatin at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000644 ! normal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990153 ! maintenance of protein localization to heterochromatin intersection_of: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990153 ! maintenance of protein localization to heterochromatin relationship: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-07-30T15:39:37Z [Term] id: FYPO:0002397 name: abnormal cytoskeleton def: "A physical cellular phenotype in which the amount, distribution, or morphology of all or part of the cytoskeleton is abnormal." [PomBase:mah] comment: Note that an abnormal cytoskeleton organization process may, but does not necessarily, result in a physically abnormal cytoskeleton. synonym: "abnormal cytoskeleton physical object quality" EXACT [PomBase:mah] is_a: FYPO:0000287 ! abnormal subcellular component intersection_of: PATO:0001241 ! physical object quality intersection_of: inheres_in GO:0005856 ! cytoskeleton intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0005856 ! cytoskeleton relationship: output_of FYPO:0000802 ! abnormal cytoskeleton organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-07-30T17:06:41Z [Term] id: FYPO:0002398 name: abnormal actin cytoskeleton during vegetative growth def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the amount, distribution, or morphology of all or part of the actin cytoskeleton is abnormal." [PomBase:mah] comment: Note that an abnormal actin cytoskeleton organization process may, but does not necessarily, result in a physically abnormal actin cytoskeleton. synonym: "abnormal actin cytoskeleton during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal actin cytoskeleton physical object quality during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: FYPO:0002397 ! abnormal cytoskeleton intersection_of: PATO:0001241 ! physical object quality intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0015629 ! actin cytoskeleton intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0015629 ! actin cytoskeleton relationship: output_of FYPO:0000801 ! abnormal actin cytoskeleton organization during vegetative growth relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-07-30T17:07:07Z [Term] id: FYPO:0002399 name: abnormal microtubule cytoskeleton def: "A physical cellular phenotype in which the amount, distribution, or morphology of all or part of the microtubule cytoskeleton is abnormal." [PomBase:mah] comment: Note that an abnormal microtubule cytoskeleton organization process may, but does not necessarily, result in a physically abnormal microtubule cytoskeleton. synonym: "abnormal microtubule cytoskeleton physical object quality" EXACT [PomBase:mah] is_a: FYPO:0002397 ! abnormal cytoskeleton intersection_of: PATO:0001241 ! physical object quality intersection_of: inheres_in GO:0015630 ! microtubule cytoskeleton intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0015630 ! microtubule cytoskeleton relationship: output_of FYPO:0000054 ! abnormal microtubule cytoskeleton organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-07-30T17:07:17Z [Term] id: FYPO:0002400 name: single microtubule bundle def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which all detectable microtubules are present in a single bundle." [PomBase:al, PomBase:mah] is_a: FYPO:0004315 ! abnormal microtubule cytoskeleton during vegetative growth created_by: midori creation_date: 2013-07-30T17:51:31Z [Term] id: FYPO:0002401 name: microtubule bundles present in greater numbers def: "A physical cellular phenotype in which cells contain more microtubule bundles than normal." [PomBase:mah] synonym: "extra microtubule bundles" EXACT [PomBase:mah] synonym: "increased level of MT bundles" EXACT [PomBase:al] synonym: "increased microtubule bundling" RELATED [PomBase:vw] synonym: "increased number of microtubule bundles" EXACT [PomBase:mah] is_a: FYPO:0004315 ! abnormal microtubule cytoskeleton during vegetative growth is_a: PATO:0002002 ! has extra parts of type intersection_of: PATO:0002002 ! has extra parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0097427 ! microtubule bundle relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0097427 ! microtubule bundle created_by: midori creation_date: 2013-07-30T17:54:44Z [Term] id: FYPO:0002402 name: viable swollen vegetative cell with abnormal cell shape def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is viable, and has an abnormal shape and a larger volume than normal." [PomBase:mah] synonym: "viable enlarged vegetative cell with abnormal cell shape" RELATED [PomBase:mah] synonym: "viable large vegetative cell with abnormal cell shape" RELATED [PomBase:vw] synonym: "viable swollen cell with abnormal cell shape during vegetative growth" EXACT [PomBase:mah] synonym: "viable swollen misshapen vegetative cell" RELATED [PomBase:mah] synonym: "viable swollen vegetative cell with abnormal cell shape during mitotic cell cycle" RELATED [PomBase:mah] synonym: "viable vegetative cell with increased cell size and abnormal cell shape" RELATED [PomBase:vw] synonym: "viable vegetative cell with increased cell volume and abnormal cell shape" EXACT [PomBase:mah] is_a: FYPO:0002197 ! viable vegetative cell with abnormal cell shape is_a: FYPO:0002377 ! viable swollen vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000025 ! swollen cell intersection_of: has_part FYPO:0001126 ! abnormal cell shape intersection_of: has_part FYPO:0001491 ! viable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000025 ! swollen cell relationship: has_part FYPO:0001126 ! abnormal cell shape relationship: has_part FYPO:0001491 ! viable vegetative cell created_by: midori creation_date: 2013-07-31T13:21:10Z [Term] id: FYPO:0002403 name: abnormal nucleus def: "A physical cellular phenotype in which the amount, distribution, or morphology of all or part of the nucleus is abnormal." [PomBase:mah] comment: Note that an abnormal cytoskeleton organization process may, but does not necessarily, result in a physically abnormal cytoskeleton. synonym: "abnormal nucleus physical object quality" EXACT [PomBase:mah] is_a: FYPO:0000287 ! abnormal subcellular component intersection_of: PATO:0001241 ! physical object quality intersection_of: inheres_in GO:0005634 ! nucleus intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0005634 ! nucleus relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-07-31T13:30:02Z [Term] id: FYPO:0002404 name: abnormal endomembrane system def: "A physical cellular phenotype in which the amount, distribution, or morphology of all or part of the endomembrane system is abnormal in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "abnormal endomembrane system during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal endomembrane system during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal endomembrane system physical object quality" EXACT [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth intersection_of: PATO:0001241 ! physical object quality intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0012505 ! endomembrane system intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0012505 ! endomembrane system relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-07-31T13:34:35Z [Term] id: FYPO:0002405 name: viable curved stubby vegetative cell def: "A cell morphology phenotype in which a vegetatively growing cell is viable and is curved along the long axis, and the cell diameter is larger than normal and the cell length is shorter than normal. In a curved cell, the long axis follows a smooth bend rather than a straight line." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "curved stubby viable cell" EXACT [PomBase:mah] synonym: "viable curved stubby cell during vegetative growth" EXACT [PomBase:mah] synonym: "viable curved stubby vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "viable curved watermelon-shaped vegetative cell" EXACT [PomBase:mah] is_a: FYPO:0002106 ! viable stubby vegetative cell is_a: FYPO:0002112 ! viable curved vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000016 ! curved vegetative cell intersection_of: has_part FYPO:0000024 ! stubby cell intersection_of: has_part FYPO:0001491 ! viable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000016 ! curved vegetative cell relationship: has_part FYPO:0000024 ! stubby cell relationship: has_part FYPO:0001491 ! viable vegetative cell created_by: midori creation_date: 2013-07-31T13:45:31Z [Term] id: FYPO:0002406 name: viable curved stubby septated vegetative cell def: "A cell morphology phenotype in which a vegetatively growing cell is viable, contains one or more septa, and is curved along the long axis, and the cell diameter is larger than normal and the cell length is shorter than normal. In a curved cell, the long axis follows a smooth bend rather than a straight line." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "curved stubby septated viable cell" EXACT [PomBase:mah] synonym: "viable curved stubby septated cell during vegetative growth" EXACT [PomBase:mah] synonym: "viable curved stubby septated vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "viable curved watermelon-shaped septated vegetative cell" EXACT [PomBase:mah] is_a: FYPO:0002405 ! viable curved stubby vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000016 ! curved vegetative cell intersection_of: has_part FYPO:0000024 ! stubby cell intersection_of: has_part FYPO:0001491 ! viable vegetative cell intersection_of: has_part FYPO:0002342 ! septated vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000016 ! curved vegetative cell relationship: has_part FYPO:0000024 ! stubby cell relationship: has_part FYPO:0001491 ! viable vegetative cell relationship: has_part FYPO:0002342 ! septated vegetative cell created_by: midori creation_date: 2013-07-31T13:49:44Z [Term] id: FYPO:0002407 name: viable curved stubby vegetative cell population def: "A cell population phenotype in which all cells in the population are viable and curved along the long axis, and the cell diameter is larger than normal and the cell length is shorter than normal, in the vegetative growth phase of the life cycle." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. synonym: "curved stubby viable vegetative cell population" EXACT [PomBase:mah] is_obsolete: true replaced_by: FYPO:0002060 created_by: midori creation_date: 2013-07-31T13:52:21Z [Term] id: FYPO:0002408 name: viable curved stubby septated vegetative cell population def: "A cell population phenotype in which all cells in the population are viable and curved along the long axis, contain one or more septa apiece, and the cell diameter is larger than normal and the cell length is shorter than normal, in the vegetative growth phase of the life cycle." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. synonym: "curved stubby septated viable vegetative cell population" EXACT [PomBase:mah] is_obsolete: true replaced_by: FYPO:0002060 created_by: midori creation_date: 2013-07-31T14:08:02Z [Term] id: FYPO:0002409 name: inviable after spore germination, single cell division, with elongated germ tube def: "A phenotype in which a spore germinates to produce an elongated germ tube, and undergoes a single round of cell division." [PomBase:mah] synonym: "essential; germinating spore, single cell division, with elongated germ tube" RELATED [PomBase:mah] synonym: "inviable after spore germination, single cell division, elongated cell" EXACT [PomBase:mah] synonym: "inviable following spore germination, single cell division, with elongated, germ tube" EXACT [PomBase:mah] synonym: "inviable germinated spore, single cell division, with elongated germ tube" EXACT [PomBase:mah] is_a: FYPO:0000314 ! inviable after spore germination with elongated germ tube is_a: FYPO:0002420 ! inviable after spore germination, single cell division, abnormal cell shape created_by: midori creation_date: 2013-07-31T14:12:14Z [Term] id: FYPO:0002410 name: inviable vacuolated vegetative cell, abnormal cell shape, normal cell size def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell is inviable, cell shape is altered, and cell size remains normal, and in which vacuoles are more visible (usually by microscopy) than normal." [PomBase:mah, PomBase:vw] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "inviable vacuolated vegetative cell with abnormal cell shape and normal cell size" RELATED [PomBase:mah] synonym: "inviable vacuolated vegetative cell, abnormal cell shape, normal cell size during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable vegetative misshapen vacuolated cell" RELATED [PomBase:vw] synonym: "inviable, vacuolated, abnormal cell shape, normal cell size during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001511 ! inviable vegetative cell, abnormal cell shape, normal cell size intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0001124 ! normal vegetative cell size intersection_of: has_part FYPO:0001126 ! abnormal cell shape intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0001581 ! vacuolated relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0001124 ! normal vegetative cell size relationship: has_part FYPO:0001126 ! abnormal cell shape relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0001581 ! vacuolated created_by: midori creation_date: 2013-07-31T14:14:55Z [Term] id: FYPO:0002411 name: inviable curved elongated vegetative cell def: "A cell morphology phenotype in which a vegetatively growing cell is inviable, is longer than normal, and is curved along the long axis. In a curved cell, the long axis follows a smooth bend rather than a straight line." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "curved elongated inviable cell" EXACT [PomBase:mah] synonym: "inviable curved elongated cell" EXACT [PomBase:mah] synonym: "inviable curved elongated cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable curved elongated vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001490 ! inviable elongated vegetative cell is_a: FYPO:0002113 ! inviable curved vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000016 ! curved vegetative cell intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000016 ! curved vegetative cell relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2013-07-31T14:32:46Z [Term] id: FYPO:0002412 name: inviable curved elongated vegetative cell population def: "A cell population phenotype in which all cells in the population are inviable, longer than normal, and curved along the long axis in the vegetative growth phase of the life cycle." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. synonym: "inviable curved long vegetative cell population" EXACT [PomBase:mah] synonym: "population of curved inviable long cells" EXACT [PomBase:vw] is_obsolete: true replaced_by: FYPO:0002061 created_by: midori creation_date: 2013-07-31T14:33:01Z [Term] id: FYPO:0002413 name: inviable curved vegetative cell population def: "A cell population phenotype in which all cells in the population are inviable and curved along the long axis in the vegetative growth phase of the life cycle." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. synonym: "inviable curved vegetative cell population" EXACT [PomBase:mah] synonym: "population of inviable curved cells" EXACT [PomBase:vw] is_obsolete: true replaced_by: FYPO:0002061 created_by: midori creation_date: 2013-07-31T14:36:48Z [Term] id: FYPO:0002414 name: inviable swollen vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is inviable and has a larger volume than normal. In a swollen cell, both length and diameter are greater than normal, although the cell is only considered elongated if the length:width ratio is also greater than normal." [PomBase:mah] synonym: "inviable enlarged vegetative cell" RELATED [PomBase:mah] synonym: "inviable large vegetative cell" RELATED [PomBase:vw] synonym: "inviable swollen cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable swollen vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable vegetative cell with increased cell size" RELATED [PomBase:vw] synonym: "inviable vegetative cell with increased cell volume" EXACT [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000025 ! swollen cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000025 ! swollen cell relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2013-07-31T15:54:54Z [Term] id: FYPO:0002415 name: inviable swollen vegetative cell with abnormal cell shape def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is inviable, and has an abnormal shape and a larger volume than normal." [PomBase:mah] synonym: "inviable enlarged vegetative cell with abnormal cell shape" RELATED [PomBase:mah] synonym: "inviable large vegetative cell with abnormal cell shape" RELATED [PomBase:vw] synonym: "inviable swollen cell with abnormal cell shape during vegetative growth" EXACT [PomBase:mah] synonym: "inviable swollen misshapen vegetative cell" RELATED [PomBase:mah] synonym: "inviable swollen vegetative cell with abnormal cell shape during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable vegetative cell with increased cell size and abnormal cell shape" RELATED [PomBase:vw] synonym: "inviable vegetative cell with increased cell volume and abnormal cell shape" EXACT [PomBase:mah] is_a: FYPO:0002414 ! inviable swollen vegetative cell is_a: FYPO:0002451 ! inviable vegetative cell with abnormal cell shape intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000025 ! swollen cell intersection_of: has_part FYPO:0001126 ! abnormal cell shape intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000025 ! swollen cell relationship: has_part FYPO:0001126 ! abnormal cell shape relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2013-07-31T16:16:47Z [Term] id: FYPO:0002416 name: inviable microcolony, swollen cells, abnormal cell shape def: "A cell population phenotype in which a cell undergoes one or a few rounds of cell division before cells die, resulting in the formation a colony that contains only a few inviable cells in which cell shape is altered and cell volume is larger than normal. Up to 6 rounds of cell division (generating 64 cells) may be observed, but 3 divisions or fewer is more typical." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype, with penetrance extensions where needed. synonym: "inviable microcolonies swollen misshapen cells" RELATED [PomBase:vw] synonym: "inviable microcolony, enlarged vegetative cells with abnormal cell shape" RELATED [PomBase:mah] synonym: "inviable microcolony, large vegetative cells with abnormal cell shape" RELATED [PomBase:vw] synonym: "inviable microcolony, vegetative cells with increased cell size and abnormal cell shape" RELATED [PomBase:vw] synonym: "inviable microcolony, vegetative cells with increased cell volume and abnormal cell shape" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-07-31T16:24:46Z [Term] id: FYPO:0002417 name: inviable mixed population including spores and germinated spores with elongated germ tubes def: "A mixed population phenotype in which all cells in a population are inviable, and the population includes a mixture of ungerminated spores and germinated spores with elongated germ tubes. The elongated cells arise from division of some of the germinated spores, and may form a microcolony of up to 64 cells." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because a "mixed population" observation would be better represented as two or more separate phenotype annotations, each with penetrance specified. synonym: "essential; mixed population including spores and germinated spores with elongated germ tubes" RELATED [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-07-31T16:27:14Z [Term] id: FYPO:0002418 name: inviable mixed population including spores, germinated spores and elongated cells def: "A mixed population phenotype in which all cells in a population are inviable, and the population includes a mixture of ungerminated spores, germinated spores and elongated vegetative cells. The spheroid cells arise from division of some of the germinated spores, and may form a microcolony of up to 64 cells." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because a "mixed population" observation would be better represented as two or more separate phenotype annotations, each with penetrance specified. synonym: "essential; mixed population including spores, germinated spores and elongated cells" RELATED [PomBase:mah] synonym: "inviable mixed population including spores, germinated spores and long cells" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-07-31T16:33:44Z [Term] id: FYPO:0002419 name: inviable vegetative cell population after spore germination, without cell division def: "A cell population phenotype in which all vegetative cells arising from a population of germinated spores are inviable, and do not divide before dying." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. synonym: "inviable germinated spore population, without cell division" EXACT [PomBase:mah] synonym: "inviable population of undivided germinated spores" EXACT [PomBase:mah] is_obsolete: true replaced_by: FYPO:0002061 created_by: midori creation_date: 2013-07-31T16:40:46Z [Term] id: FYPO:0002420 name: inviable after spore germination, single cell division, abnormal cell shape def: "A phenotype in which a spore germinates to produce cell that has an abnormal shape and undergoes a single round of cell division." [PomBase:mah] synonym: "essential; germinating spore, single cell division, abnormal cell shape" RELATED [PomBase:mah] synonym: "inviable following spore germination, single cell division, abnormal cell shape" EXACT [PomBase:mah] synonym: "inviable germinated spore, single cell division, abnormal cell shape" EXACT [PomBase:mah] is_a: FYPO:0002280 ! inviable after spore germination, single cell division created_by: midori creation_date: 2013-07-31T16:48:55Z [Term] id: FYPO:0002421 name: inviable after spore germination, single or double cell division, abnormal cell shape def: "A phenotype in which a spore germinates to produce a cell that has an abnormal shape and undergoes one or two rounds of cell division." [PomBase:mah] synonym: "essential; germinating spore, single or double cell division, abnormal cell shape" RELATED [PomBase:mah] synonym: "inviable following spore germination, single or double cell division, abnormal cell shape" EXACT [PomBase:mah] synonym: "inviable germinated spore, single cell or double division, abnormal cell shape" EXACT [PomBase:mah] is_a: FYPO:0001042 ! inviable after spore germination, single or double cell division created_by: midori creation_date: 2013-07-31T16:57:30Z [Term] id: FYPO:0002422 name: inviable vegetative cell population after spore germination, single or double cell division, abnormal cell shape def: "A cell population phenotype in which all vegetative cells arising from a population of germinated spores are inviable, have an abnormal shape and undergo one or two rounds of cell division." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. synonym: "inviable germinated spore population, single or double cell division, abnormal cell shape" EXACT [PomBase:mah] synonym: "inviable population of germinated spores, single or double cell division, abnormal cell shape" EXACT [PomBase:mah] is_obsolete: true replaced_by: FYPO:0002061 created_by: midori creation_date: 2013-07-31T16:58:52Z [Term] id: FYPO:0002423 name: inviable after spore germination, without cell division, septated cells with abnormal cell shape def: "A phenotype in which a spore germinates to produce an inviable cell that forms a septum but does not divide, and that has an abnormal shape." [PomBase:mah] synonym: "essential; germinating spore, without cell division, septated cells with abnormal cell shape" RELATED [PomBase:mah] synonym: "inviable after spore germination, septated undivided abnormally shaped cell" EXACT [PomBase:mah] synonym: "inviable after spore germination, undivided septated cells with abnormal cell shape" EXACT [PomBase:mah] synonym: "inviable following spore germination, without cell division, septated cells with abnormal cell shape" EXACT [PomBase:mah] synonym: "inviable germinated spore, without cell division, septated cells with abnormal cell shape" EXACT [PomBase:mah] is_a: FYPO:0001991 ! inviable after spore germination, without cell division created_by: midori creation_date: 2013-07-31T17:14:02Z [Term] id: FYPO:0002424 name: normal actin cortical patch localization during mitotic interphase def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which actin cortical patch localization is normal (i.e. indistinguishable from wild type) during interphase of the mitotic cell cycle." [PomBase:mah] synonym: "normal actin cortical patch localisation during mitotic interphase" EXACT [PomBase:mah] synonym: "normal actin cortical patch localization during mitotic interphase during vegetative growth" EXACT [PomBase:mah] synonym: "normal actin cortical patch location during mitotic interphase" RELATED [PomBase:mah] is_a: FYPO:0001294 ! normal actin cortical patch localization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0051329 ! mitotic interphase intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051666 ! actin cortical patch localization intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0051329 ! mitotic interphase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051666 ! actin cortical patch localization relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-08-01T17:10:00Z [Term] id: FYPO:0002425 name: abnormal actin cable organization during mitosis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which actin cable organization is abnormal during mitosis. The process normally results in the assembly, arrangement of constituent parts, or disassembly of an actin cable. Actin cables are the form of actin filament bundles found in yeasts." [GO:0032432, PomBase:mah] synonym: "abnormal actin cable organisation during mitotic interphase" EXACT [PomBase:mah] synonym: "abnormal actin cable organization during mitotic interphase during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal actin cable organization during mitotic M phase" EXACT [PomBase:mah] synonym: "abnormal actin cable organization during mitotic nuclear division" EXACT [GO:0007067] synonym: "abnormal actin filament bundle organization during mitotic interphase" EXACT [GO:0032432] is_a: FYPO:0002030 ! abnormal actin cable organization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0007067 ! mitotic nuclear division intersection_of: inheres_in_part_of GO:0061572 ! actin filament bundle organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0007067 ! mitotic nuclear division relationship: inheres_in_part_of GO:0061572 ! actin filament bundle organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-08-01T17:15:08Z [Term] id: FYPO:0002426 name: inviable mixed population including divided and undivided germinated spores def: "A mixed population phenotype in which all cells in a population are inviable germinated spores, and in which some cells divide once and others do not divide. In the cells that divide once, an inviable cell forms from the growing end of the germ tube, but does not divide further." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because a "mixed population" observation would be better represented as two or more separate phenotype annotations, each with penetrance specified. synonym: "essential; mixed population including divided and undivided germinated spores" RELATED [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-08-02T14:13:03Z [Term] id: FYPO:0002427 name: inviable spore with abnormal shape def: "A viability phenotype in which a spore is unable to survive under conditions in which wild type spores survive, and has an abnormal shape. An inviable spore does not germinate." [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: has_part FYPO:0001126 ! abnormal cell shape intersection_of: has_part FYPO:0002151 ! inviable spore relationship: has_part FYPO:0001126 ! abnormal cell shape relationship: has_part FYPO:0002151 ! inviable spore created_by: midori creation_date: 2013-08-02T14:15:29Z [Term] id: FYPO:0002428 name: inviable mixed population including germinated spores with elongated germ tubes and cells with normal morphology def: "A mixed population phenotype in which all cells in a population are inviable, and the population includes a mixture of germinated spores with elongated germ tubes and vegetative cells of normal size and shape. The vegetative cells arise from division of some of the germinated spores, and may form a microcolony of up to 64 cells." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because a "mixed population" observation would be better represented as two or more separate phenotype annotations, each with penetrance specified. synonym: "essential; mixed population including germinated spores with elongated germ tubes and cells with normal morphology" RELATED [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-08-02T15:25:58Z [Term] id: FYPO:0002429 name: inviable after spore germination, multiple cell divisions, abnormal cell shape, normal cell size def: "A phenotype in which a spore germinates to produce a cell of abnormal shape and normal size that undergoes two or more rounds of cell division and then dies." [PomBase:mah] synonym: "essential; germinating spore, multiple cell divisions, abnormal cell shape, normal cell size" RELATED [PomBase:mah] synonym: "inviable germinated spore, multiple cell divisions, abnormal cell shape, normal cell size" EXACT [PomBase:mah] is_a: FYPO:0001511 ! inviable vegetative cell, abnormal cell shape, normal cell size is_a: FYPO:0002148 ! inviable after spore germination, multiple cell divisions, abnormal morphology is_a: FYPO:0002199 ! inviable vegetative cell with normal cell morphology created_by: midori creation_date: 2013-08-02T15:42:43Z [Term] id: FYPO:0002430 name: inviable after spore germination, multiple cell divisions def: "A phenotype in which a spore germinates to produce a cell that undergoes two or more rounds of cell division, and then dies." [PomBase:al, PomBase:mah] synonym: "essential; germinating spore, multiple cell divisions" RELATED [PomBase:mah] synonym: "inviable following spore germination, multiple cell divisions" EXACT [PomBase:mah] synonym: "inviable germinated spore, multiple cell divisions, normal morphology" EXACT [PomBase:mah] is_a: FYPO:0000316 ! inviable after spore germination created_by: midori creation_date: 2013-08-02T16:39:51Z [Term] id: FYPO:0002431 name: inviable mixed population including germinated spores with abnormal shape and cells with abnormal shape def: "A mixed population phenotype in which all cells in a population are inviable, and the population includes a mixture of germinated spores of abnormal shape and vegetative cells of abnormal shape. The vegetative cells arise from division of some of the germinated spores, and may form a microcolony of up to 64 cells." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because a "mixed population" observation would be better represented as two or more separate phenotype annotations, each with penetrance specified. synonym: "essential; mixed population including germinated spores with abnormal shape and cells with abnormal shape" RELATED [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-08-06T12:00:58Z [Term] id: FYPO:0002432 name: inviable mixed population including germinated spores and cells with abnormal shape def: "A mixed population phenotype in which all cells in a population are inviable, and the population includes a mixture of germinated spores and vegetative cells of abnormal shape. The vegetative cells arise from division of some of the germinated spores, and may form a microcolony of up to 64 cells." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because a "mixed population" observation would be better represented as two or more separate phenotype annotations, each with penetrance specified. synonym: "essential; mixed population including germinated spores and cells with abnormal shape" RELATED [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-08-06T12:02:33Z [Term] id: FYPO:0002433 name: inviable vegetative cell population with abnormal cell shape def: "A cell population phenotype in which all cells in the population are inviable and have abnormal cell shape, in the vegetative growth phase of the life cycle." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. synonym: "inviable, abnormally shaped vegetative cell population" EXACT [PomBase:mah] is_obsolete: true replaced_by: FYPO:0002061 created_by: midori creation_date: 2013-08-06T12:07:07Z [Term] id: FYPO:0002434 name: short actin cables def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells form actin cables that are shorter than normal." [PomBase:mah] synonym: "decreased actin cable length" EXACT [PomBase:mah] synonym: "short actin cables during mitotic cell cycle" RELATED [PomBase:mah] synonym: "short actin cables during vegetative growth" EXACT [PomBase:mah] synonym: "short actin filament bundles" EXACT [PomBase:mah] is_a: FYPO:0002031 ! abnormal actin cable morphology is_a: PATO:0000574 ! decreased length intersection_of: PATO:0000574 ! decreased length intersection_of: inheres_in GO:0032432 ! actin filament bundle relationship: inheres_in GO:0032432 ! actin filament bundle created_by: midori creation_date: 2013-08-06T12:19:34Z [Term] id: FYPO:0002435 name: abnormal actin cables def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the amount, distribution, or morphology of actin cables is abnormal. Actin cables are the form of actin filament bundles found in yeasts." [PomBase:mah] synonym: "abnormal actin cables during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal actin cables during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal actin filament bundles" EXACT [PomBase:mah] is_a: FYPO:0002398 ! abnormal actin cytoskeleton during vegetative growth intersection_of: PATO:0001241 ! physical object quality intersection_of: inheres_in GO:0032432 ! actin filament bundle intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0032432 ! actin filament bundle relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-08-06T12:25:22Z [Term] id: FYPO:0002436 name: misoriented actin cables def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the orientation of actin cables within a cell is abnormal." [PomBase:mah] synonym: "abnormal actin cable orientation" EXACT [PomBase:mah] synonym: "abnormal actin filament bundle orientation" EXACT [PomBase:mah] synonym: "misoriented actin cables during mitotic cell cycle" RELATED [PomBase:mah] synonym: "misoriented actin cables during vegetative growth" EXACT [PomBase:mah] synonym: "misoriented actin filament bundles" EXACT [PomBase:mah] is_a: FYPO:0002435 ! abnormal actin cables is_a: PATO:0000133 ! orientation intersection_of: PATO:0000133 ! orientation intersection_of: inheres_in GO:0032432 ! actin filament bundle intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0032432 ! actin filament bundle relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-08-06T12:31:15Z [Term] id: FYPO:0002437 name: thick actin cables def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells form actin cables that are thicker than normal." [PomBase:mah] synonym: "increased actin cable thickness" EXACT [PomBase:mah] synonym: "thick actin cables during mitotic cell cycle" RELATED [PomBase:mah] synonym: "thick actin cables during vegetative growth" EXACT [PomBase:mah] synonym: "thick actin filament bundles" EXACT [PomBase:mah] is_a: FYPO:0002031 ! abnormal actin cable morphology is_a: PATO:0000591 ! increased thickness intersection_of: PATO:0000591 ! increased thickness intersection_of: inheres_in GO:0032432 ! actin filament bundle relationship: inheres_in GO:0032432 ! actin filament bundle created_by: midori creation_date: 2013-08-06T12:34:30Z [Term] id: FYPO:0002438 name: short, misoriented actin cables def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells form actin cables that are shorter than normal and abnormally oriented within the cell." [PomBase:mah] synonym: "short, abnormally oriented actin cables" EXACT [PomBase:mah] synonym: "short, misoriented actin cables during mitotic cell cycle" RELATED [PomBase:mah] synonym: "short, misoriented actin cables during vegetative growth" EXACT [PomBase:mah] synonym: "short, misoriented actin filament bundles" EXACT [PomBase:mah] is_a: FYPO:0004638 ! abnormal cellular physical quality phenotype intersection_of: PATO:0001241 ! physical object quality intersection_of: has_part FYPO:0002434 ! short actin cables intersection_of: has_part FYPO:0002436 ! misoriented actin cables relationship: has_part FYPO:0002434 ! short actin cables relationship: has_part FYPO:0002436 ! misoriented actin cables created_by: midori creation_date: 2013-08-06T12:35:34Z [Term] id: FYPO:0002439 name: short, thick, misoriented actin cables def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells form actin cables that are shorter and thicker than normal, and abnormally oriented within the cell." [PomBase:mah] synonym: "short, thick, abnormally oriented actin cables" EXACT [PomBase:mah] synonym: "short, thick, misoriented actin cables during mitotic cell cycle" RELATED [PomBase:mah] synonym: "short, thick, misoriented actin cables during vegetative growth" EXACT [PomBase:mah] synonym: "short, thick, misoriented actin filament bundles" EXACT [PomBase:mah] is_a: FYPO:0002438 ! short, misoriented actin cables intersection_of: PATO:0001241 ! physical object quality intersection_of: has_part FYPO:0002434 ! short actin cables intersection_of: has_part FYPO:0002436 ! misoriented actin cables intersection_of: has_part FYPO:0002437 ! thick actin cables relationship: has_part FYPO:0002434 ! short actin cables relationship: has_part FYPO:0002436 ! misoriented actin cables relationship: has_part FYPO:0002437 ! thick actin cables created_by: midori creation_date: 2013-08-06T12:37:33Z [Term] id: FYPO:0002440 name: abnormal actin cable distribution def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which actin cable distribution is abnormal. The process normally establishes the spatial arrangement of actin cables within the cell. Actin cables are the form of actin filament bundles found in yeasts." [PomBase:mah] synonym: "abnormal actin cable distribution during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal actin cable distribution during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal actin filament bundle distribution" EXACT [PomBase:mah] is_a: FYPO:0002030 ! abnormal actin cable organization intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0070650 ! actin filament bundle distribution intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0070650 ! actin filament bundle distribution relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-08-06T12:43:32Z [Term] id: FYPO:0002441 name: decreased rate of actin cable retrograde transport def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the rate, or speed, of actin cable retrograde transport is lower than normal. The process normally arrangement of actin cables from the periphery toward the interior of the cell. Actin cables are the form of actin filament bundles found in yeasts." [PMID:23051734, PomBase:mah] synonym: "decreased rate of actin cable retrograde transport during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased rate of actin cable retrograde transport during vegetative growth" EXACT [PomBase:mah] synonym: "decreased rate of actin filament bundle retrograde flow" EXACT [PMID:23051734] synonym: "decreased rate of actin filament bundle retrograde transport" EXACT [PomBase:mah] synonym: "reduced rate of actin cable retrograde transport" EXACT [PomBase:mah] is_a: FYPO:0002440 ! abnormal actin cable distribution is_a: PATO:0000911 ! decreased rate intersection_of: PATO:0000911 ! decreased rate intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0061573 ! actin filament bundle retrograde transport relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0061573 ! actin filament bundle retrograde transport created_by: midori creation_date: 2013-08-06T12:45:13Z [Term] id: FYPO:0002442 name: normal protein localization to cell division site def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the site of cell division is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to cell division site" EXACT [PomBase:mah] synonym: "normal protein localization to cell division site during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to cell division site during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000644 ! normal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072741 ! protein localization to cell division site intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072741 ! protein localization to cell division site relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-08-06T12:50:51Z [Term] id: FYPO:0002443 name: normal rate of actin cable retrograde transport def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the rate, or speed, of actin cable retrograde transport is normal (i.e. indistinguishable from wild type). The process results in arrangement of actin cables from the periphery toward the interior of the cell. Actin cables are the form of actin filament bundles found in yeasts." [PMID:23051734, PomBase:mah] synonym: "normal rate of actin cable retrograde transport during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal rate of actin cable retrograde transport during vegetative growth" EXACT [PomBase:mah] synonym: "normal rate of actin filament bundle retrograde flow" EXACT [PMID:23051734] synonym: "normal rate of actin filament bundle retrograde transport" EXACT [PomBase:mah] is_a: FYPO:0001366 ! normal actin cytoskeleton organization is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate intersection_of: inheres_in GO:0061573 ! actin filament bundle retrograde transport intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0061573 ! actin filament bundle retrograde transport relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-08-06T13:03:18Z [Term] id: FYPO:0002444 name: loss of punctate cytoplasmic protein localization def: "A cell phenotype in which a protein that is normally localized to discrete regions in the cytoplasm, visible as foci or dots by fluorescence microscopy, is abnormally localized such that dots cannot be observed." [PomBase:mah] synonym: "abolished punctate cytoplasmic protein localization" EXACT [PomBase:mah] synonym: "cytoplasmic dots absent" RELATED [PomBase:mah] synonym: "loss of punctate cytoplasmic protein localisation" EXACT [PomBase:mah] synonym: "loss of punctate cytoplasmic protein localization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "loss of punctate cytoplasmic protein localization during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000782 ! mislocalized protein during vegetative growth created_by: midori creation_date: 2013-08-06T13:54:47Z [Term] id: FYPO:0002445 name: protein mislocalized to actin cortical patch def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a protein that is not normally found in actin cortical patches is observed there." [PomBase:mah] comment: Note that this term can be used to annotate any case where a protein is found in actin cortical patches in a mutant, but not in wild type. In some cases, there may be enough additional information to annotate to 'abnormal protein localization' (FYPO:0000443) or one of its descendants. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "ectopic protein localization to actin cortical patch" EXACT [PomBase:vw] synonym: "protein mislocalised to actin cortical patch" EXACT [PomBase:mah] synonym: "protein mislocalised to actin cortical patch during vegetative growth" EXACT [PomBase:mah] synonym: "protein mislocalized to actin cortical patch during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein mislocalized to actin cortical patch during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000782 ! mislocalized protein during vegetative growth intersection_of: PATO:0000628 ! mislocalised intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CHEBI:36080 ! protein intersection_of: towards GO:0030479 ! actin cortical patch relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CHEBI:36080 ! protein relationship: towards GO:0030479 ! actin cortical patch created_by: midori creation_date: 2013-08-06T13:56:32Z [Term] id: FYPO:0002446 name: decreased protein phosphorylation during cellular response to hydrogen peroxide def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal during a cellular response to hydrogen peroxide." [PomBase:mah] synonym: "decreased protein phosphorylation during cellular response to H2O2" EXACT [PomBase:mah] synonym: "decreased protein phosphorylation during cellular response to hydrogen peroxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein phosphorylation during cellular response to hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein phosphorylation during cellular response to H2O2" EXACT [PomBase:mah] synonym: "reduced protein phosphorylation during cellular response to hydrogen peroxide" EXACT [PomBase:mah] is_a: FYPO:0001838 ! decreased protein phosphorylation during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0070301 ! cellular response to hydrogen peroxide intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0070301 ! cellular response to hydrogen peroxide relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2013-08-06T13:58:08Z [Term] id: FYPO:0002447 name: abnormal protein N-linked glycosylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the N-glycosylation of one or more specific proteins, or of specific protein sites, is abnormal. Protein N-linked glycosylation is the addition of a carbohydrate or carbohydrate derivative unit to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GO:0006487, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein N-glycosylation" EXACT [PomBase:mah] synonym: "abnormal protein N-linked glycosylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein N-linked glycosylation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001910 ! abnormal protein glycosylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006487 ! protein N-linked glycosylation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006487 ! protein N-linked glycosylation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-08-06T13:59:25Z [Term] id: FYPO:0002448 name: normal Dsc complex assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which Dsc E3 ubiquitin ligase complex assembly is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal Dsc complex assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal Dsc complex assembly during vegetative growth" EXACT [PomBase:mah] synonym: "normal Dsc E3 ubiquitin ligase assembly" EXACT [GO:1990155] is_a: FYPO:0001215 ! normal protein complex assembly intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990155 ! Dsc E3 ubiquitin ligase complex assembly intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990155 ! Dsc E3 ubiquitin ligase complex assembly relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-08-06T14:02:34Z [Term] id: FYPO:0002449 name: signal recognition particles present in decreased numbers def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells contain fewer signal recognition particles (SRPs) than normal." [PomBase:mah] synonym: "decreased level of SRPs" RELATED [PomBase:al] synonym: "decreased signal recognition particle formation during vegetative growth" RELATED [PomBase:mah] synonym: "fewer signal recognition particles present during vegetative growth" EXACT [PomBase:mah] synonym: "signal recognition particles present in decreased numbers during mitotic cell cycle" RELATED [PomBase:mah] synonym: "signal recognition particles present in decreased numbers during vegetative growth" EXACT [PomBase:mah] synonym: "signal recognition particles present in reduced numbers" EXACT [PomBase:mah] synonym: "SRPs present in decreased numbers" EXACT [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: PATO:0002001 ! has fewer parts of type intersection_of: PATO:0002001 ! has fewer parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0048500 ! signal recognition particle relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0048500 ! signal recognition particle created_by: midori creation_date: 2013-08-06T14:17:38Z [Term] id: FYPO:0002450 name: inviable after spore germination, multiple cell divisions, septated cell with abnormal morphology def: "A phenotype in which a spore germinates to produce a cell that is septated and has abnormal morphology (i.e. size, shape, or structure), and that undergoes two or more rounds of cell division and then dies." [PomBase:al, PomBase:mah] synonym: "essential; germinating spore, multiple cell divisions, septated cell with abnormal morphology" RELATED [PomBase:mah] synonym: "inviable following spore germination, multiple cell divisions, septated cell with abnormal morphology" EXACT [PomBase:mah] synonym: "inviable germinated spore, multiple cell divisions, septated cell with abnormal morphology" EXACT [PomBase:mah] is_a: FYPO:0002148 ! inviable after spore germination, multiple cell divisions, abnormal morphology created_by: midori creation_date: 2013-08-06T14:25:13Z [Term] id: FYPO:0002451 name: inviable vegetative cell with abnormal cell shape def: "A cell phenotype in which a cell is inviable and cell shape is altered in the vegetative growth phase of the life cycle." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "inviable vegetative cell with abnormal cell shape during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable, abnormal cell shape during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0001126 ! abnormal cell shape intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0001126 ! abnormal cell shape relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2013-08-06T14:40:39Z [Term] id: FYPO:0002452 name: inviable septated vegetative cell with abnormal cell morphology def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell contains one or more septa, has abnormal morphology (i.e. size, shape, or structure) and is inviable." [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0001118 ! abnormal vegetative cell morphology intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0002342 ! septated vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0001118 ! abnormal vegetative cell morphology relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0002342 ! septated vegetative cell created_by: midori creation_date: 2013-08-06T14:42:46Z [Term] id: FYPO:0002453 name: inviable microcolony, septated cells with abnormal morphology def: "A cell population phenotype in which a cell undergoes one or a few rounds of cell division before cells die, resulting in the formation a colony that contains only a few inviable cells that have abnormal morphology (i.e. size, shape, or structure) and contain one or more septa apiece. Up to 6 rounds of cell division (generating 64 cells) may be observed, but 3 divisions or fewer is more typical." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype, with penetrance extensions where needed. synonym: "inviable microcolony, septated vegetative cells with abnormal morphology" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-08-06T14:44:38Z [Term] id: FYPO:0002454 name: inviable vegetative cell population with abnormal cell morphology def: "A cell population phenotype in which all cells in the population are inviable and have abnormal cell morphology (i.e. size, shape, or structure), in the vegetative growth phase of the life cycle." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. is_obsolete: true replaced_by: FYPO:0002061 created_by: midori creation_date: 2013-08-06T14:46:31Z [Term] id: FYPO:0002455 name: abnormal septum during vegetative growth def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the position or morphology of all or part of the septum is abnormal." [PomBase:mah] comment: Note that an septum organization process may, but does not necessarily, result in a physically abnormal septum. synonym: "abnormal septum during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal septum physical object quality during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: FYPO:0004292 ! abnormal septum intersection_of: PATO:0001241 ! physical object quality intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000935 ! barrier septum intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000935 ! barrier septum relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-08-06T15:00:01Z [Term] id: FYPO:0002456 name: viable curved vegetative cell with abnormal septum def: "A cell morphology phenotype in which a vegetatively growing cell is viable, is curved along the long axis, and contains one or more abnormal septa. In a curved cell, the long axis follows a smooth bend rather than a straight line." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "curved viable cell with abnormal septum" EXACT [PomBase:mah] synonym: "viable curved abnormally septated vegetative cell" EXACT [PomBase:mah, PomBase:vw] synonym: "viable curved cell with abnormal septum during vegetative growth" EXACT [PomBase:mah] synonym: "viable curved vegetative cell with abnormal septum during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0002112 ! viable curved vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000016 ! curved vegetative cell intersection_of: has_part FYPO:0001491 ! viable vegetative cell intersection_of: has_part FYPO:0002455 ! abnormal septum during vegetative growth relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000016 ! curved vegetative cell relationship: has_part FYPO:0001491 ! viable vegetative cell relationship: has_part FYPO:0002455 ! abnormal septum during vegetative growth created_by: midori creation_date: 2013-08-06T15:04:59Z [Term] id: FYPO:0002457 name: viable curved elongated vegetative cell with abnormal septum def: "A cell morphology phenotype in which a vegetatively growing cell is viable, is longer than normal, is curved along the long axis, and contains one or more abnormal septa. In a curved cell, the long axis follows a smooth bend rather than a straight line." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "curved elongated viable cell with abnormal septum" EXACT [PomBase:mah] synonym: "viable curved elongated abnormally septated vegetative cell" EXACT [PomBase:mah, PomBase:vw] synonym: "viable curved elongated cell with abnormal septum during vegetative growth" EXACT [PomBase:mah] synonym: "viable curved elongated vegetative cell with abnormal septum during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0002215 ! viable curved elongated vegetative cell is_a: FYPO:0002456 ! viable curved vegetative cell with abnormal septum intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000016 ! curved vegetative cell intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0001491 ! viable vegetative cell intersection_of: has_part FYPO:0002455 ! abnormal septum during vegetative growth relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000016 ! curved vegetative cell relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0001491 ! viable vegetative cell relationship: has_part FYPO:0002455 ! abnormal septum during vegetative growth created_by: midori creation_date: 2013-08-06T15:08:11Z [Term] id: FYPO:0002459 name: viable branched, elongated vegetative cell alt_id: FYPO:0002458 def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is viable, branched, septated, and longer than normal." [PomBase:jh, PomBase:mah] synonym: "viable branched cell during vegetative growth" EXACT [PomBase:mah] synonym: "viable branched elongated vegetative cell" EXACT [PomBase:vw] synonym: "viable branched vegetative cell" EXACT [PomBase:mah] synonym: "viable branched vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "viable branched, elongated cell during vegetative growth" EXACT [PomBase:mah] synonym: "viable branched, elongated vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "viable branched, elongated, septated cell" EXACT [PomBase:jh, PomBase:mah, PomBase:vw] synonym: "viable branched, long, septated cell" EXACT [PomBase:vw] synonym: "viable branched, septated cell" EXACT [PomBase:jh, PomBase:mah, PomBase:vw] synonym: "viable elongated branched cell" EXACT [PomBase:vw] is_a: FYPO:0001492 ! viable elongated vegetative cell is_a: FYPO:0004594 ! branched, elongated, septated cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000015 ! branched vegetative cell intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0001491 ! viable vegetative cell intersection_of: has_part FYPO:0002342 ! septated vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000015 ! branched vegetative cell relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0001491 ! viable vegetative cell relationship: has_part FYPO:0002342 ! septated vegetative cell created_by: midori creation_date: 2013-08-06T15:21:13Z [Term] id: FYPO:0002460 name: viable branched, curved, elongated vegetative cell alt_id: FYPO:0002477 def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is viable, branched, septated, longer than normal, and is curved along the long axis." [PomBase:mah] synonym: "viable branched curved cell" EXACT [PomBase:vw] synonym: "viable branched, curved cell during vegetative growth" EXACT [PomBase:mah] synonym: "viable branched, curved septated cell" EXACT [PomBase:jh, PomBase:mah, PomBase:vw] synonym: "viable branched, curved vegetative cell" EXACT [PomBase:mah] synonym: "viable branched, curved vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "viable branched, curved, elongated cell during vegetative growth" EXACT [PomBase:mah] synonym: "viable branched, curved, elongated vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "viable branched, elongated, curved septated cell" EXACT [PomBase:jh, PomBase:mah, PomBase:vw] synonym: "viable branched, long, curved, septated cell" EXACT [PomBase:vw] synonym: "viable curved branched cell" EXACT [PomBase:vw] synonym: "viable elongated branched curved cell" EXACT [PomBase:vw] is_a: FYPO:0002215 ! viable curved elongated vegetative cell is_a: FYPO:0002459 ! viable branched, elongated vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000015 ! branched vegetative cell intersection_of: has_part FYPO:0000016 ! curved vegetative cell intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0001491 ! viable vegetative cell intersection_of: has_part FYPO:0002342 ! septated vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000015 ! branched vegetative cell relationship: has_part FYPO:0000016 ! curved vegetative cell relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0001491 ! viable vegetative cell relationship: has_part FYPO:0002342 ! septated vegetative cell created_by: midori creation_date: 2013-08-06T15:25:18Z [Term] id: FYPO:0002462 name: inviable branched, elongated vegetative cell alt_id: FYPO:0002461 def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is inviable, branched, septated, and longer than normal." [PomBase:jh, PomBase:mah] synonym: "inviable branched cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable branched vegetative cell" EXACT [PomBase:mah] synonym: "inviable branched vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable branched, elongated cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable branched, elongated vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable branched, elongated, septated cell" EXACT [PomBase:jh, PomBase:mah, PomBase:vw] synonym: "inviable branched, long, septated cell" EXACT [PomBase:vw] synonym: "inviable branched, septated cell" EXACT [PomBase:jh, PomBase:mah, PomBase:vw] synonym: "inviable elongated branched cell" EXACT [PomBase:vw] is_a: FYPO:0001490 ! inviable elongated vegetative cell is_a: FYPO:0002452 ! inviable septated vegetative cell with abnormal cell morphology is_a: FYPO:0004594 ! branched, elongated, septated cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000015 ! branched vegetative cell intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0002342 ! septated vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000015 ! branched vegetative cell relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0002342 ! septated vegetative cell created_by: midori creation_date: 2013-08-06T15:55:03Z [Term] id: FYPO:0002463 name: inviable branched, curved, elongated vegetative cell alt_id: FYPO:0002481 def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is inviable, branched, septated, longer than normal, and is curved along the long axis." [PomBase:mah] synonym: "inviable branched curved cell" EXACT [PomBase:vw] synonym: "inviable branched, curved cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable branched, curved septated cell" EXACT [PomBase:jh, PomBase:mah, PomBase:vw] synonym: "inviable branched, curved vegetative cell" EXACT [PomBase:mah] synonym: "inviable branched, curved vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable branched, curved, elongated cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable branched, curved, elongated vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable branched, elongated, curved septated cell" EXACT [PomBase:jh, PomBase:mah, PomBase:vw] synonym: "inviable branched, long, curved, septated cell" EXACT [PomBase:vw] synonym: "inviable curved branched cell" EXACT [PomBase:vw] synonym: "inviable curved branched elongated cell" EXACT [PomBase:vw] synonym: "inviable elongated branched curved cell" EXACT [PomBase:vw] is_a: FYPO:0002282 ! inviable curved septated vegetative cell is_a: FYPO:0002411 ! inviable curved elongated vegetative cell is_a: FYPO:0002462 ! inviable branched, elongated vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000015 ! branched vegetative cell intersection_of: has_part FYPO:0000016 ! curved vegetative cell intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0002342 ! septated vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000015 ! branched vegetative cell relationship: has_part FYPO:0000016 ! curved vegetative cell relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0002342 ! septated vegetative cell created_by: midori creation_date: 2013-08-06T15:55:34Z [Term] id: FYPO:0002464 name: inviable microcolony, branched, curved, elongated cells def: "A cell population phenotype in which a cell undergoes one or a few rounds of cell division before cells die, resulting in the formation a colony that contains only a few inviable cells that are curved along the long axis, longer than normal, and branched (and septated). Up to 6 rounds of cell division (generating 64 cells) may be observed, but 3 divisions or fewer is more typical." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype, with penetrance extensions where needed. synonym: "inviable microcolony, branched, curved, elongated, septated vegetative cells" EXACT [PomBase:vw] synonym: "inviable microcolony, curved, branched, elongated cells " EXACT [PomBase:vw] is_obsolete: true created_by: midori creation_date: 2013-08-06T16:01:01Z [Term] id: FYPO:0002465 name: inviable spore population with abnormal spore shape def: "A cell population phenotype in which none of the cells in a population of spores are viable, and all have an abnormal shape. Inviable spores do not germinate." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. synonym: "inviable population of spores with abnormal shape" EXACT [PomBase:vw] synonym: "inviable spore population with abnormal shape" EXACT [PomBase:mah] is_obsolete: true replaced_by: FYPO:0002150 created_by: midori creation_date: 2013-08-06T16:15:29Z [Term] id: FYPO:0002466 name: inviable mixed population including spores, germinated spores and cells with abnormal morphology def: "A mixed population phenotype in which all cells in a population are inviable, and the population includes a mixture of ungerminated spores, germinated spores and cells with abnormal morphology (i.e. size, shape, or structure). The cells with normal morphology arise from division of some of the germinated spores, and may form a microcolony of up to 64 cells." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because a "mixed population" observation would be better represented as two or more separate phenotype annotations, each with penetrance specified. synonym: "essential; mixed population including spores, germinated spores and cells with abnormal morphology" RELATED [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-08-06T16:17:57Z [Term] id: FYPO:0002467 name: abnormal spore shape def: "A cell phenotype in which a spore has an abnormal shape." [PomBase:mah] is_a: FYPO:0000348 ! abnormal spore morphology is_a: FYPO:0001126 ! abnormal cell shape intersection_of: PATO:0000052 ! shape intersection_of: inheres_in CL:0000596 ! sexual spore intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in CL:0000596 ! sexual spore relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-08-06T16:31:13Z [Term] id: FYPO:0002468 name: inviable swollen elongated vegetative cell population def: "A cell population phenotype in which all cells in the population are inviable, have a larger volume and are longer than normal in the vegetative growth phase of the life cycle. In a swollen cell, both length and diameter are greater than normal, although the cell is only considered elongated if the length:width ratio is also greater than normal." [PomBase:mah] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype plus a full-penetrance extension. synonym: "inviable elongated cell population with increased cell volume" EXACT [PomBase:mah] synonym: "inviable elongated swollen population" EXACT [PomBase:vw] synonym: "inviable enlarged elongated cell population" RELATED [PomBase:mah] synonym: "inviable large elongated cell population" RELATED [PomBase:vw] synonym: "inviable swollen long vegetative cell population" EXACT [PomBase:mah] is_obsolete: true replaced_by: FYPO:0002061 created_by: midori creation_date: 2013-08-08T11:06:30Z [Term] id: FYPO:0002469 name: inviable microcolony, elongated tapered cells def: "A cell population phenotype in which a cell undergoes one or a few rounds of cell division before cells die, resulting in the formation a colony that contains only a few inviable cells that are longer than normal and taper at one end to a diameter smaller than the other. Up to 6 rounds of cell division (generating 64 cells) may be observed, but 3 divisions or fewer is more typical." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype, with penetrance extensions where needed. synonym: "inviable microcolony, elongated bottle/skittle cells" EXACT [PomBase:mah] synonym: "inviable microcolony, elongated skittle-shaped cells" EXACT [PomBase:mah] synonym: "inviable microcolony, elongated tapered vegetative cells" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-08-08T11:17:14Z [Term] id: FYPO:0002470 name: decreased protein phosphorylation during cellular response to ionizing radiation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal during a cellular response to ionizing radiation." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein phosphorylation during cellular response to ionizing radiation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein phosphorylation during cellular response to ionizing radiation during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein phosphorylation during cellular response to IR" EXACT [PomBase:mah] synonym: "reduced protein phosphorylation during cellular response to ionizing radiation" EXACT [PomBase:mah] synonym: "reduced protein phosphorylation during cellular response to IR" EXACT [PomBase:mah] is_a: FYPO:0001838 ! decreased protein phosphorylation during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0071479 ! cellular response to ionizing radiation intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0071479 ! cellular response to ionizing radiation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2013-08-08T11:27:46Z [Term] id: FYPO:0002471 name: abolished protein phosphorylation during cellular response to ionizing radiation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, does not occur during a cellular response to ionizing radiation." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein phosphorylation during cellular response to ionizing radiation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein phosphorylation during cellular response to ionizing radiation during vegetative growth" EXACT [PomBase:mah] synonym: "abolished protein phosphorylation during cellular response to IR" EXACT [PomBase:mah] synonym: "protein phosphorylation abolished during cellular response to ionizing radiation" EXACT [PomBase:mah] is_a: FYPO:0002033 ! abolished protein phosphorylation during vegetative growth intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0071479 ! cellular response to ionizing radiation intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0006468 ! protein phosphorylation relationship: during GO:0071479 ! cellular response to ionizing radiation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2013-08-08T11:33:54Z [Term] id: FYPO:0002472 name: abolished histone H2A phosphorylation during cellular response to ionizing radiation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of histone H2A does not occur during a cellular response to ionizing radiation." [PomBase:mah] synonym: "abolished H2A phosphorylation during cellular response to IR" EXACT [PomBase:al] synonym: "abolished histone H2A phosphorylation during cellular response to ionizing radiation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished histone H2A phosphorylation during cellular response to ionizing radiation during vegetative growth" EXACT [PomBase:mah] synonym: "abolished histone H2A phosphorylation during cellular response to IR" EXACT [PomBase:mah] synonym: "histone H2A phosphorylation abolished during cellular response to ionizing radiation" EXACT [PomBase:mah] synonym: "histone H2A phosphorylation abolished during cellular response to IR" EXACT [PomBase:mah] is_a: FYPO:0002471 ! abolished protein phosphorylation during cellular response to ionizing radiation is_a: FYPO:0002597 ! abolished histone H2A phosphorylation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0071479 ! cellular response to ionizing radiation intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1990164 ! histone H2A phosphorylation relationship: during GO:0071479 ! cellular response to ionizing radiation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1990164 ! histone H2A phosphorylation created_by: midori creation_date: 2013-08-08T11:33:54Z [Term] id: FYPO:0002473 name: abnormal protein localization to double-strand break site def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the region of a chromosome at which a DNA double-strand break has occurred is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found at double-strand break sites and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to double-strand break site" EXACT [PomBase:mah] synonym: "abnormal protein localization to double-strand break site during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein localization to double-strand break site during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal protein localization to DSB site" EXACT [PomBase:al] synonym: "abnormal protein localization to site of double-strand break" EXACT [GO:0035861, PomBase:mah] is_a: FYPO:0002838 ! abnormal protein localization to chromosome intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1990166 ! protein localization to site of double-strand break intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1990166 ! protein localization to site of double-strand break relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-08-08T12:23:37Z [Term] id: FYPO:0002474 name: decreased protein localization to double-strand break site def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the region of a chromosome at which a DNA double-strand break has occurred is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to double-strand break site" EXACT [PomBase:mah] synonym: "decreased protein localization to double-strand break site during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to double-strand break site during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein localization to DSB site" EXACT [PomBase:al] synonym: "decreased protein localization to site of double-strand break" EXACT [GO:0035861, PomBase:mah] synonym: "reduced protein localization to double-strand break site" EXACT [PomBase:mah] is_a: FYPO:0002473 ! abnormal protein localization to double-strand break site is_a: FYPO:0002839 ! decreased protein localization to chromosome intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990166 ! protein localization to site of double-strand break relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990166 ! protein localization to site of double-strand break created_by: midori creation_date: 2013-08-08T12:23:48Z [Term] id: FYPO:0002475 name: increased protein localization to double-strand break site def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the region of a chromosome at which a DNA double-strand break has occurred is increased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to double-strand break site" EXACT [PomBase:mah] synonym: "increased protein localization to double-strand break site during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein localization to double-strand break site during vegetative growth" EXACT [PomBase:mah] synonym: "increased protein localization to DSB site" EXACT [PomBase:al] synonym: "increased protein localization to site of double-strand break" EXACT [GO:0035861, PomBase:mah] is_a: FYPO:0002473 ! abnormal protein localization to double-strand break site is_a: FYPO:0002840 ! increased protein localization to chromosome intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990166 ! protein localization to site of double-strand break relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990166 ! protein localization to site of double-strand break created_by: midori creation_date: 2013-08-08T12:24:07Z [Term] id: FYPO:0002476 name: viable vacuolated vegetative cell, abnormal cell shape, normal cell size def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell is viable, cell shape is altered, and cell size remains normal, and in which vacuoles are more visible (usually by microscopy) than normal." [PomBase:mah, PomBase:vw] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "viable vacuolated vegetative cell with abnormal cell shape and normal cell size" RELATED [PomBase:mah] synonym: "viable vacuolated vegetative cell, abnormal cell shape, normal cell size during mitotic cell cycle" RELATED [PomBase:mah] synonym: "viable vegetative misshapen vacuolated cell" RELATED [PomBase:vw] synonym: "viable, vacuolated, abnormal cell shape, normal cell size during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001510 ! viable vegetative cell, abnormal cell shape, normal cell size intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0001124 ! normal vegetative cell size intersection_of: has_part FYPO:0001126 ! abnormal cell shape intersection_of: has_part FYPO:0001491 ! viable vegetative cell intersection_of: has_part FYPO:0001581 ! vacuolated relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0001124 ! normal vegetative cell size relationship: has_part FYPO:0001126 ! abnormal cell shape relationship: has_part FYPO:0001491 ! viable vegetative cell relationship: has_part FYPO:0001581 ! vacuolated created_by: midori creation_date: 2013-08-08T12:32:29Z [Term] id: FYPO:0002478 name: viable curved vacuolated vegetative cell def: "A cell morphology phenotype in which a vegetatively growing cell is viable and is curved along the long axis, and in which vacuoles are more visible (usually by microscopy) than normal. In a curved cell, the long axis follows a smooth bend rather than a straight line." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "curved vacuolated viable cell" EXACT [PomBase:mah] synonym: "viable curved vacuolated cell during vegetative growth" EXACT [PomBase:mah] synonym: "viable curved vacuolated vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0002112 ! viable curved vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000016 ! curved vegetative cell intersection_of: has_part FYPO:0001491 ! viable vegetative cell intersection_of: has_part FYPO:0001581 ! vacuolated relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000016 ! curved vegetative cell relationship: has_part FYPO:0001491 ! viable vegetative cell relationship: has_part FYPO:0001581 ! vacuolated created_by: midori creation_date: 2013-08-08T13:18:21Z [Term] id: FYPO:0002479 name: viable swollen elongated vegetative cell def: "A cell morphology phenotype in which a vegetative cell is viable and has a larger volume, and is longer, than normal. In a swollen cell, both length and diameter are greater than normal, although the cell is only considered elongated if the length:width ratio is also greater than normal." [PomBase:mah] synonym: "viable elongated cell with increased cell volume" EXACT [PomBase:mah] synonym: "viable enlarged elongated cell" RELATED [PomBase:mah] synonym: "viable large elongated cell" RELATED [PomBase:vw] synonym: "viable swollen elongated cell during vegetative growth" EXACT [PomBase:mah] synonym: "viable swollen elongated vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001429 ! swollen elongated cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000025 ! swollen cell intersection_of: has_part FYPO:0001491 ! viable vegetative cell relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000025 ! swollen cell relationship: has_part FYPO:0001491 ! viable vegetative cell created_by: midori creation_date: 2013-08-08T13:22:32Z [Term] id: FYPO:0002480 name: viable after spore germination with elongated germ tube def: "A phenotype in which a spore germinates to produce an elongated germ tube, and subsequently forms a viable dividing cell." [PomBase:mah] synonym: "viable following spore germination with elongated germ tube" EXACT [PomBase:mah] synonym: "viable germinated spore with elongated germ tube" EXACT [PomBase:mah] is_a: FYPO:0001492 ! viable elongated vegetative cell created_by: midori creation_date: 2013-08-08T13:37:23Z [Term] id: FYPO:0002482 name: inviable spheroid vegetative cell def: "A cell morphology phenotype in which a vegetatively growing cell is inviable, and shaped in the form of a spheroid. In spheroid cells, there is much less difference between the long and short axes of the cell than in wild type. Spheroid cells may shorter than normal, with approximately the same diameter as normal, or they may be enlarged." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "inviable round vegetative cell" RELATED [PomBase:mah] synonym: "inviable rounded vegetative cell" EXACT [PomBase:mah] synonym: "inviable spheroid cell" EXACT [PomBase:mah] synonym: "inviable spheroid cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable spheroid vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "spheroid inviable cell" EXACT [PomBase:mah] is_a: FYPO:0002451 ! inviable vegetative cell with abnormal cell shape intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000021 ! spheroid vegetative cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000021 ! spheroid vegetative cell relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2013-08-08T13:50:47Z [Term] id: FYPO:0002483 name: inviable small tapered vegetative cell def: "A cell morphology phenotype in which a vegetatively growing cell is inviable, has an abnormally low volume, and tapers at one end to a diameter smaller than the other. The cell diameter at the narrow end is smaller than that of a wild-type cell." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "essential; small tapered vegetative cell" RELATED [PomBase:mah] synonym: "inviable small bottle-shaped vegetative cell" EXACT [PomBase:vw] synonym: "inviable small bottle-shaped vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable small bottle/skittle vegetative cell" EXACT [PomBase:mah] synonym: "inviable small skittle-shaped vegetative cell" EXACT [PomBase:mah] synonym: "inviable small tapered cell during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000951 ! inviable small vegetative cell is_a: FYPO:0002111 ! inviable tapered vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000014 ! tapered cell intersection_of: has_part FYPO:0000023 ! small cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000014 ! tapered cell relationship: has_part FYPO:0000023 ! small cell relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2013-08-08T13:58:49Z [Term] id: FYPO:0002484 name: increased resolution of meiotic recombination intermediates with crossover formation def: "A cellular process phenotype in which the resolution of meiotic recombination intermediates results in the formation of a crossover at a higher frequency than normal." [PMID:22723423, PomBase:mah] synonym: "increased occurrence of meiotic cross-overs" RELATED [PMID:22723423, PomBase:al] is_a: FYPO:0000008 ! abnormal meiotic recombination created_by: midori creation_date: 2013-08-08T14:57:12Z [Term] id: FYPO:0002485 name: decreased resolution of meiotic recombination intermediates with crossover formation def: "A cellular process phenotype in which the resolution of meiotic recombination intermediates results in the formation of a crossover at a lower frequency than normal." [PMID:22723423, PomBase:mah] synonym: "decreased occurrence of meiotic cross-overs" RELATED [PMID:22723423, PomBase:al] synonym: "reduced resolution of meiotic recombination intermediates with crossover formation" EXACT [PomBase:mah] is_a: FYPO:0000008 ! abnormal meiotic recombination created_by: midori creation_date: 2013-08-08T15:07:01Z [Term] id: FYPO:0002486 name: decreased meiotic strand displacement def: "A cellular process phenotype in which the occurrence of meiotic strand displacement is decreased. Meiotic strand displacement is the part of meiotic recombination in which the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA is rejected." [GO:0000714, PMID:22723423, PomBase:mah] synonym: "decreased D-loop unwinding" RELATED [PMID:22723423, PomBase:al] synonym: "decreased meiotic D-loop dissociation" EXACT [GO:0000714] synonym: "decreased meiotic D-loop processing" RELATED [GO:0000714] synonym: "reduced meiotic strand displacement" EXACT [PomBase:mah] is_a: FYPO:0000008 ! abnormal meiotic recombination is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0000714 ! meiotic strand displacement relationship: inheres_in GO:0000714 ! meiotic strand displacement created_by: midori creation_date: 2013-08-08T15:07:43Z [Term] id: FYPO:0002487 name: normal actin cable morphology def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, and structure of actin cables are normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal actin cable morphology during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal actin cable morphology during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001313 ! normal subcellular component during vegetative growth is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0032432 ! actin filament bundle intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0032432 ! actin filament bundle relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-08-08T15:14:52Z [Term] id: FYPO:0002488 name: cell lysis def: "An inviable phenotype in which a cell lyses, i.e. the plasma membrane ruptures and cytoplasm is lost. Note that in fission yeast cell lysis, the integrity of the cell wall is also compromised." [PomBase:mah] synonym: "cytolysis" EXACT [PomBase:mah] synonym: "inviable, lysed cell" EXACT [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0019835 ! cytolysis relationship: has_part FYPO:0000049 ! inviable cell relationship: inheres_in GO:0019835 ! cytolysis created_by: midori creation_date: 2013-08-08T15:17:46Z [Term] id: FYPO:0002489 name: spore lysis def: "An inviable phenotype in which a spore lyses, i.e. the plasma membrane ruptures and cytoplasm is lost. Note that in fission yeast cell lysis, the integrity of the cell wall is also compromised." [PomBase:mah] synonym: "inviable, lysed spore" EXACT [PomBase:vw] synonym: "spore cytolysis" EXACT [PomBase:mah] is_a: FYPO:0002488 ! cell lysis intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0019835 ! cytolysis intersection_of: towards CL:0000596 ! sexual spore relationship: has_part FYPO:0002151 ! inviable spore relationship: inheres_in GO:0019835 ! cytolysis relationship: towards CL:0000596 ! sexual spore created_by: midori creation_date: 2013-08-08T15:26:41Z [Term] id: FYPO:0002490 name: inviable after spore germination, multiple cell divisions, swollen cell def: "A phenotype in which a spore germinates to produce a cell that has a greater length, diameter, and volume than normal, and undergoes two or more rounds of cell division and then dies." [PomBase:mah] synonym: "essential; germinating spore, multiple cell divisions, swollen cell" RELATED [PomBase:mah] synonym: "inviable after spore germination, multiple cell divisions, enlarged cell" RELATED [PomBase:mah] synonym: "inviable after spore germination, multiple cell divisions, increased cell size" RELATED [PomBase:vw] synonym: "inviable after spore germination, multiple cell divisions, increased cell volume" EXACT [PomBase:mah] synonym: "inviable after spore germination, multiple cell divisions, large cell" RELATED [PomBase:vw] synonym: "inviable following spore germination, multiple cell divisions, swollen cell" EXACT [PomBase:mah] synonym: "inviable germinated spore, multiple cell divisions, swollen cell" EXACT [PomBase:mah] is_a: FYPO:0002148 ! inviable after spore germination, multiple cell divisions, abnormal morphology created_by: midori creation_date: 2013-08-08T15:29:22Z [Term] id: FYPO:0002491 name: abnormal DNA 5'-adenosine monophosphate hydrolase activity def: "A molecular function phenotype in which the observed rate of DNA 5'-adenosine monophosphate hydrolase activity is abnormal." [PomBase:mah] is_a: FYPO:0003163 ! abnormal nuclease activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0033699 ! DNA 5'-adenosine monophosphate hydrolase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0033699 ! DNA 5'-adenosine monophosphate hydrolase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-08-08T15:38:20Z [Term] id: FYPO:0002492 name: abolished DNA 5'-adenosine monophosphate hydrolase activity def: "A molecular function phenotype in which DNA 5'-adenosine monophosphate hydrolase activity is absent." [PomBase:mah] synonym: "DNA 5'-adenosine monophosphate hydrolase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0002491 ! abnormal DNA 5'-adenosine monophosphate hydrolase activity is_a: FYPO:0003164 ! abolished nuclease activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0033699 ! DNA 5'-adenosine monophosphate hydrolase activity relationship: towards GO:0033699 ! DNA 5'-adenosine monophosphate hydrolase activity created_by: midori creation_date: 2013-08-08T15:38:33Z [Term] id: FYPO:0002493 name: decreased DNA 5'-adenosine monophosphate hydrolase activity def: "A molecular function phenotype in which the observed rate of DNA 5'-adenosine monophosphate hydrolase activity is decreased." [PomBase:mah] synonym: "reduced DNA 5'-adenosine monophosphate hydrolase activity" EXACT [PomBase:mah] is_a: FYPO:0002491 ! abnormal DNA 5'-adenosine monophosphate hydrolase activity is_a: FYPO:0004253 ! decreased nuclease activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0033699 ! DNA 5'-adenosine monophosphate hydrolase activity relationship: inheres_in GO:0033699 ! DNA 5'-adenosine monophosphate hydrolase activity created_by: midori creation_date: 2013-08-08T15:38:46Z [Term] id: FYPO:0002494 name: abnormal protein modification def: "A cellular process phenotype in which protein modification is abnormal. All modifications may be affected, or only modifications of a certain type, or on specific proteins, or even specific sites within specific proteins." [GO:0030163, PomBase:mah] is_a: FYPO:0002274 ! abnormal protein metabolic process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0006464 ! cellular protein modification process intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0006464 ! cellular protein modification process relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-08-08T15:45:44Z [Term] id: FYPO:0002495 name: normal protein modification def: "A cellular process phenotype in which protein modification is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal protein/peptide modification" EXACT [PomBase:mah] synonym: "protein/peptide modification: normal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0002496 ! normal metabolic process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0006464 ! cellular protein modification process intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0006464 ! cellular protein modification process relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-08-08T15:49:50Z [Term] id: FYPO:0002496 name: normal metabolic process def: "A cellular process phenotype in which a cellular metabolic process is normal (i.e. indistinguishable from wild type). A metabolic process is any set of chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances." [GO:0044237, PomBase:mah] synonym: "normal cellular metabolic process" EXACT [GO:0044237, PomBase:mah] synonym: "normal metabolism" EXACT [GO:0044237, PomBase:mah] is_a: FYPO:0000627 ! normal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0044237 ! cellular metabolic process intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0044237 ! cellular metabolic process relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-08-08T15:51:57Z [Term] id: FYPO:0002497 name: abolished protein modification def: "A cellular process phenotype in which protein modification does not occur. All modifications may be affected, or only modifications of a certain type, or on specific proteins, or even specific sites within specific proteins." [PomBase:mah] synonym: "abolished protein/peptide modification" EXACT [PomBase:mah] synonym: "absent protein/peptide modification" EXACT [PomBase:mah] synonym: "protein modification abolished" EXACT [PomBase:mah] synonym: "protein/peptide modification: absent" EXACT [SGD:phenotype_annotation] is_a: FYPO:0002494 ! abnormal protein modification is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0006464 ! cellular protein modification process relationship: towards GO:0006464 ! cellular protein modification process created_by: midori creation_date: 2013-08-08T15:57:24Z [Term] id: FYPO:0002498 name: decreased protein modification def: "A cellular process phenotype in which the occurrence of protein modification is decreased. All modifications may be affected, or only modifications of a certain type, or on specific proteins, or even specific sites within specific proteins." [PomBase:mah] synonym: "decreased protein/peptide modification" EXACT [PomBase:mah] synonym: "protein/peptide modification: decreased" EXACT [SGD:phenotype_annotation] synonym: "reduced protein modification" EXACT [PomBase:mah] is_a: FYPO:0002494 ! abnormal protein modification is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0006464 ! cellular protein modification process relationship: inheres_in GO:0006464 ! cellular protein modification process created_by: midori creation_date: 2013-08-08T15:59:37Z [Term] id: FYPO:0002499 name: increased protein modification def: "A cellular process phenotype in which the occurrence of protein modification is increased. All modifications may be affected, or only modifications of a certain type, or on specific proteins, or even specific sites within specific proteins." [PomBase:mah] synonym: "increased protein/peptide modification" EXACT [PomBase:mah] synonym: "protein/peptide modification: increased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0002494 ! abnormal protein modification is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0006464 ! cellular protein modification process relationship: inheres_in GO:0006464 ! cellular protein modification process created_by: midori creation_date: 2013-08-08T15:59:46Z [Term] id: FYPO:0002500 name: normal protein palmitoylation def: "A cellular process phenotype in which protein palmitoylation is normal (i.e. indistinguishable from wild type). Protein palmitoylation is the addition of a palmitoyl group to a protein amino acid." [GO:0018345, PomBase:mah] synonym: "normal protein/peptide palmitoylation" EXACT [PomBase:mah] is_a: FYPO:0002495 ! normal protein modification intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0018345 ! protein palmitoylation intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0018345 ! protein palmitoylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-08-08T16:06:16Z [Term] id: FYPO:0002501 name: normal protein palmitoylation during meiosis def: "A cellular process phenotype in which protein palmitoylation is normal (i.e. indistinguishable from wild type) during one or both meiotic nuclear divisions. Protein palmitoylation is the addition of a palmitoyl group to a protein amino acid." [GO:0018345, PomBase:mah] synonym: "normal protein/peptide palmitoylation during meiosis" EXACT [PomBase:mah] is_a: FYPO:0002500 ! normal protein palmitoylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0007126 ! meiotic nuclear division intersection_of: inheres_in GO:0018345 ! protein palmitoylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0007126 ! meiotic nuclear division relationship: inheres_in GO:0018345 ! protein palmitoylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-08-08T16:07:40Z [Term] id: FYPO:0002502 name: normal protein palmitoylation during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which protein palmitoylation is normal (i.e. indistinguishable from wild type). Protein palmitoylation is the addition of a palmitoyl group to a protein amino acid." [GO:0018345, PomBase:mah] synonym: "normal protein palmitoylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein/peptide palmitoylation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000549 ! normal protein modification during vegetative growth is_a: FYPO:0002500 ! normal protein palmitoylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0018345 ! protein palmitoylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0018345 ! protein palmitoylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-08-08T16:08:20Z [Term] id: FYPO:0002503 name: abnormal protein palmitoylation def: "A cellular process phenotype in which the palmitoylation of one or more specific proteins is abnormal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. is_a: FYPO:0002494 ! abnormal protein modification intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0018345 ! protein palmitoylation intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0018345 ! protein palmitoylation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-08-08T16:09:58Z [Term] id: FYPO:0002504 name: abolished protein palmitoylation def: "A cellular process phenotype in which the palmitoylation of one or more specific proteins, or of specific protein sites, does not occur." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "protein palmitoylation abolished" EXACT [PomBase:mah] synonym: "protein palmitoylation absent" EXACT [PomBase:al] is_a: FYPO:0002497 ! abolished protein modification is_a: FYPO:0002503 ! abnormal protein palmitoylation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0018345 ! protein palmitoylation relationship: towards GO:0018345 ! protein palmitoylation created_by: midori creation_date: 2013-08-08T16:11:12Z [Term] id: FYPO:0002505 name: decreased protein palmitoylation def: "A cellular process phenotype in which the palmitoylation of one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "reduced protein palmitoylation" EXACT [PomBase:mah] is_a: FYPO:0002498 ! decreased protein modification is_a: FYPO:0002503 ! abnormal protein palmitoylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0018345 ! protein palmitoylation relationship: inheres_in GO:0018345 ! protein palmitoylation created_by: midori creation_date: 2013-08-08T16:11:34Z [Term] id: FYPO:0002506 name: abnormal protein palmitoylation during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the palmitoylation of one or more specific proteins is abnormal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein palmitoylation during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000329 ! abnormal protein modification during vegetative growth is_a: FYPO:0002503 ! abnormal protein palmitoylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0018345 ! protein palmitoylation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0018345 ! protein palmitoylation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-08-08T16:12:26Z [Term] id: FYPO:0002507 name: abolished protein palmitoylation during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the palmitoylation of one or more specific proteins, or of specific protein sites, does not occur." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein palmitoylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein palmitoylation abolished during vegetative growth" EXACT [PomBase:mah] synonym: "protein palmitoylation absent during vegetative growth" EXACT [PomBase:al] is_a: FYPO:0000544 ! abolished protein modification during vegetative growth is_a: FYPO:0002504 ! abolished protein palmitoylation is_a: FYPO:0002506 ! abnormal protein palmitoylation during vegetative growth intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0018345 ! protein palmitoylation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0018345 ! protein palmitoylation created_by: midori creation_date: 2013-08-08T16:12:34Z [Term] id: FYPO:0002508 name: decreased protein palmitoylation during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the palmitoylation of one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein palmitoylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "reduced protein palmitoylation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000545 ! decreased protein modification during vegetative growth is_a: FYPO:0002505 ! decreased protein palmitoylation is_a: FYPO:0002506 ! abnormal protein palmitoylation during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0018345 ! protein palmitoylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0018345 ! protein palmitoylation created_by: midori creation_date: 2013-08-08T16:12:43Z [Term] id: FYPO:0002509 name: increased protein palmitoylation def: "A cellular process phenotype in which the palmitoylation of one or more specific proteins, or of specific protein sites, occurs to a greater extent than normal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. is_a: FYPO:0002499 ! increased protein modification is_a: FYPO:0002503 ! abnormal protein palmitoylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0018345 ! protein palmitoylation relationship: inheres_in GO:0018345 ! protein palmitoylation created_by: midori creation_date: 2013-08-08T16:21:52Z [Term] id: FYPO:0002510 name: increased protein palmitoylation during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the palmitoylation of one or more specific proteins, or of specific protein sites, occurs to a greater extent than normal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein palmitoylation during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000547 ! increased protein modification during vegetative growth is_a: FYPO:0002506 ! abnormal protein palmitoylation during vegetative growth is_a: FYPO:0002509 ! increased protein palmitoylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0018345 ! protein palmitoylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0018345 ! protein palmitoylation created_by: midori creation_date: 2013-08-08T16:22:35Z [Term] id: FYPO:0002511 name: abolished protein palmitoylation during meiosis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the palmitoylation of one or more specific proteins, or of specific protein sites, does not occur during one or both meiotic nuclear divisions." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "protein palmitoylation abolished during meiosis" EXACT [PomBase:mah] synonym: "protein palmitoylation absent during meiosis" EXACT [PomBase:al] is_a: FYPO:0002504 ! abolished protein palmitoylation is_a: FYPO:0002514 ! abnormal protein palmitoylation during meiosis intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0007126 ! meiotic nuclear division intersection_of: towards GO:0018345 ! protein palmitoylation relationship: during GO:0007126 ! meiotic nuclear division relationship: towards GO:0018345 ! protein palmitoylation created_by: midori creation_date: 2013-08-08T16:24:46Z [Term] id: FYPO:0002512 name: decreased protein palmitoylation during meiosis def: "A cellular process phenotype in which the palmitoylation of one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal during one or both meiotic nuclear divisions." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "reduced protein palmitoylation during meiosis" EXACT [PomBase:mah] is_a: FYPO:0002505 ! decreased protein palmitoylation is_a: FYPO:0002514 ! abnormal protein palmitoylation during meiosis intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0007126 ! meiotic nuclear division intersection_of: inheres_in GO:0018345 ! protein palmitoylation relationship: happens_during GO:0007126 ! meiotic nuclear division relationship: inheres_in GO:0018345 ! protein palmitoylation created_by: midori creation_date: 2013-08-08T16:25:18Z [Term] id: FYPO:0002513 name: increased protein palmitoylation during meiosis def: "A cellular process phenotype in which the palmitoylation of one or more specific proteins, or of specific protein sites, occurs to a greater extent than normal during one or both meiotic nuclear divisions." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. is_a: FYPO:0002509 ! increased protein palmitoylation is_a: FYPO:0002514 ! abnormal protein palmitoylation during meiosis intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0007126 ! meiotic nuclear division intersection_of: inheres_in GO:0018345 ! protein palmitoylation relationship: happens_during GO:0007126 ! meiotic nuclear division relationship: inheres_in GO:0018345 ! protein palmitoylation created_by: midori creation_date: 2013-08-08T16:45:45Z [Term] id: FYPO:0002514 name: abnormal protein palmitoylation during meiosis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the palmitoylation of one or more specific proteins is abnormal during one or both meiotic nuclear divisions." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. is_a: FYPO:0002503 ! abnormal protein palmitoylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0007126 ! meiotic nuclear division intersection_of: inheres_in_part_of GO:0018345 ! protein palmitoylation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0007126 ! meiotic nuclear division relationship: inheres_in_part_of GO:0018345 ! protein palmitoylation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-08-08T16:46:03Z [Term] id: FYPO:0002515 name: inviable after spore germination, without cell division, with branched, elongated germ tube def: "A phenotype in which a spore germinates to produce an elongated, branched germ tube, but does not go on to form a viable dividing cell." [PomBase:mah] synonym: "essential; germinating spore with elongated, branched germ tube" RELATED [PomBase:mah] synonym: "inviable after spore germination, without cell division, branched, elongated cell" EXACT [PomBase:mah] synonym: "inviable following spore germination with elongated, branched germ tube" EXACT [PomBase:mah] synonym: "inviable germinated spore, without cell division, with elongated, branched germ tube" EXACT [PomBase:mah] is_a: FYPO:0002379 ! inviable after spore germination, without cell division, with elongated germ tube is_a: FYPO:0002462 ! inviable branched, elongated vegetative cell created_by: midori creation_date: 2013-08-15T12:05:24Z [Term] id: FYPO:0002516 name: advanced mitotic G2/M transition def: "A cell cycle phenotype in which the G2/M transition of the mitotic cell cycle begins earlier than normal. The duration of G2 phase is thus shorter than normal." [PomBase:mah] comment: A G2/M advance may indicate that a checkpoint, such as the DNA replication checkpoint or the G2/M DNA damage checkpoint, is impaired. Checkpoint activation can be tested using checkpoint kinase mutants. synonym: "advanced cell cycle progression through mitotic G2/M phase transition" EXACT [PomBase:mah] synonym: "advanced mitotic G2 phase progression" RELATED [PomBase:mah] synonym: "cell cycle, mitotic G2 advance" RELATED [PomBase:mah] synonym: "decreased duration of mitotic G2 phase" RELATED [PomBase:mah] synonym: "decreased duration of mitotic G2 phase during vegetative growth" RELATED [PomBase:mah] synonym: "decreased mitotic G2 duration" RELATED [PomBase:mah] synonym: "increased rate of mitotic G2 phase progression" RELATED [PomBase:mah] synonym: "mitotic cell cycle advance at G2/M transition" EXACT [PomBase:mah] synonym: "mitotic G2 advance" RELATED [PomBase:mah] synonym: "mitotic G2/M transition advance" EXACT [PomBase:mah] synonym: "mitotic G2/M transition advance during vegetative growth" EXACT [PomBase:mah] synonym: "premature mitotic G2/M transition" EXACT [PomBase:mah] synonym: "premature mitotic G2/M transition during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000399 ! abnormal mitotic G2/M phase transition is_a: FYPO:0000563 ! abnormal mitotic G2 phase progression is_a: FYPO:0000827 ! advanced cell cycle phase transition intersection_of: PATO:0000694 ! premature intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000086 ! G2/M transition of mitotic cell cycle relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000086 ! G2/M transition of mitotic cell cycle created_by: midori creation_date: 2013-08-15T14:12:36Z [Term] id: FYPO:0002517 name: abnormal response to mitotic cell cycle checkpoint signaling def: "A cellular process phenotype in which a mitotic cell cycle arrest that normally occurs in response to mitotic cell cycle checkpoint signaling is abnormal (does not occur, or occurs abnormally). Abnormal arrest may result from a problem with detection of conditions that normally trigger a checkpoint, transduction of the checkpoint signal, or the response to the checkpoint signal." [PomBase:mah] synonym: "abnormal mitotic cell cycle checkpoint arrest" RELATED [PomBase:mah] synonym: "abnormal occurrence of mitotic cell cycle arrest resulting from checkpoint activation" RELATED [PomBase:mah] synonym: "abnormal occurrence of mitotic cell cycle arrest resulting from defective checkpoint activation" RELATED [PomBase:vw] is_a: FYPO:0000011 ! abnormal cell cycle is_a: FYPO:0001342 ! cellular response phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0072414 ! response to mitotic cell cycle checkpoint signaling intersection_of: qualifier PATO:0000460 ! abnormal relationship: has_output FYPO:0001026 ! abnormal occurrence of normal mitotic cell cycle arrest relationship: inheres_in_part_of GO:0072414 ! response to mitotic cell cycle checkpoint signaling relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-08-15T14:28:54Z [Term] id: FYPO:0002518 name: abolished response to mitotic cell cycle checkpoint signaling def: "A cellular process phenotype in which a mitotic cell cycle arrest that normally occurs in response to cell cycle checkpoint signaling does not occur. Abolished arrest may result from a problem with detection of conditions that normally trigger a checkpoint, transduction of the checkpoint signal, or the response to the checkpoint signal." [PomBase:mah] comment: May indicate that a cell cycle checkpoint is not activated under conditions that normally trigger checkpoint signaling and subsequent cell cycle arrest. synonym: "abolished cell cycle checkpoint arrest" RELATED [PomBase:mah] synonym: "cell cycle arrest resulting from mitotic cell cycle checkpoint activation abolished" EXACT [GO:0072414] is_a: FYPO:0002517 ! abnormal response to mitotic cell cycle checkpoint signaling is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0072414 ! response to mitotic cell cycle checkpoint signaling relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_output FYPO:0000827 ! advanced cell cycle phase transition relationship: towards GO:0072414 ! response to mitotic cell cycle checkpoint signaling created_by: midori creation_date: 2013-08-15T14:45:22Z [Term] id: FYPO:0002519 name: abolished response to mitotic G2/M transition checkpoint signaling def: "A cellular process phenotype in which a cell cycle arrest that normally occurs in response to mitotic G2/M transition cell cycle checkpoint signaling does not occur. Abolished arrest may result from a problem with detection of conditions that normally trigger a checkpoint, transduction of the checkpoint signal, or the response to the checkpoint signal." [PomBase:mah] comment: May indicate that a checkpoint, such as the DNA replication checkpoint or the G2/M DNA damage checkpoint, is not activated under conditions that normally trigger checkpoint signaling and subsequent cell cycle arrest. synonym: "abolished mitotic G2/M transition arrest" RELATED [PomBase:mah] synonym: "cell cycle arrest resulting from mitotic G2/M transition checkpoint activation abolished" EXACT [PomBase:mah] synonym: "mitotic G2/M checkpoint arrest deficient" RELATED [PomBase:vw] is_a: FYPO:0002518 ! abolished response to mitotic cell cycle checkpoint signaling relationship: has_output FYPO:0002516 ! advanced mitotic G2/M transition created_by: midori creation_date: 2013-08-15T14:49:04Z [Term] id: FYPO:0002520 name: decreased frequency of conjugation with h+ cells def: "A conjugation phenotype in which conjugation by a mutant with wild type h+ occurs less frequently than normal." [PomBase:mah] synonym: "decreased conjugation with WT h+ cells" EXACT [PomBase:vw] synonym: "decreased frequency of conjugation with h plus cells" EXACT [PomBase:mah] synonym: "reduced frequency of conjugation with h+ cells" EXACT [PomBase:mah] is_a: FYPO:0000303 ! decreased conjugation frequency created_by: midori creation_date: 2013-08-15T15:10:31Z [Term] id: FYPO:0002521 name: decreased frequency of conjugation with h- cells def: "A conjugation phenotype in which conjugation by a mutant with wild type h- occurs less frequently than normal." [PomBase:mah] synonym: "decreased conjugation with WT h- cells" EXACT [PomBase:vw] synonym: "decreased frequency of conjugation with h minus cells" EXACT [PomBase:mah] synonym: "reduced frequency of conjugation with h- cells" EXACT [PomBase:mah] is_a: FYPO:0000303 ! decreased conjugation frequency created_by: midori creation_date: 2013-08-15T15:12:10Z [Term] id: FYPO:0002522 name: decreased poly(A)+ mRNA export from nucleus def: "A transport phenotype observed in the vegetative growth phase of the life cycle in which the export of polyadenylated mRNA from the nucleus is decreased. Export of all polyadenylated mRNAs or a specific mRNA may be affected." [PomBase:mah] comment: We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased poly(A)+ mRNA export from nucleus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased poly(A)+ mRNA export from nucleus during vegetative growth" EXACT [PomBase:mah] synonym: "reduced poly(A)+ mRNA export from nucleus" EXACT [PomBase:mah] is_a: FYPO:0000183 ! abnormal poly(A)+ mRNA export from nucleus is_a: FYPO:0000508 ! decreased nuclear export intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0016973 ! poly(A)+ mRNA export from nucleus relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0016973 ! poly(A)+ mRNA export from nucleus created_by: midori creation_date: 2013-08-15T15:14:49Z [Term] id: FYPO:0002523 name: abnormal NADPH-hemoprotein reductase activity def: "A molecular function phenotype in which the observed rate of NADPH-hemoprotein reductase activity is abnormal." [PomBase:mah] is_a: FYPO:0000689 ! abnormal oxidoreductase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0003958 ! NADPH-hemoprotein reductase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0003958 ! NADPH-hemoprotein reductase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-08-15T15:20:21Z [Term] id: FYPO:0002524 name: increased NADPH-hemoprotein reductase activity def: "A molecular function phenotype in which the observed rate of NADPH-hemoprotein reductase activity is increased." [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0002523 ! abnormal NADPH-hemoprotein reductase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0003958 ! NADPH-hemoprotein reductase activity relationship: inheres_in GO:0003958 ! NADPH-hemoprotein reductase activity created_by: midori creation_date: 2013-08-15T15:20:39Z [Term] id: FYPO:0002525 name: normal chromosome morphology def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, and structure of one or more chromosomes are normal." [PomBase:mah] comment: Note that an abnormal chromosome organization process may, but does not necessarily, result in abnormal chromosome morphology. synonym: "normal chromosome morphology during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal chromosome morphology during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001313 ! normal subcellular component during vegetative growth is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005694 ! chromosome intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005694 ! chromosome relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-08-15T15:22:34Z [Term] id: FYPO:0002526 name: sensitive to latrunculin B def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to latrunculin B. Cells stop growing (and may die) at a concentration of latrunculin B that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to latrunculin B" EXACT [PomBase:mah] synonym: "sensitive to latrunculin B during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to latrunculin B during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:49703 ! latrunculin B relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:49703 ! latrunculin B created_by: midori creation_date: 2013-08-27T14:23:03Z [Term] id: FYPO:0002527 name: increased duration of protein localization to cell division site def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which a protein is localized to the cell division site for longer than normal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased duration of protein localisation to cell division site" EXACT [PomBase:mah] synonym: "increased duration of protein localization to cell division site during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased duration of protein localization to cell division site during vegetative growth" EXACT [PomBase:mah] synonym: "prolonged protein localization to cell division site" EXACT [PomBase:mah] is_a: FYPO:0001401 ! abnormal protein localization to cell division site is_a: PATO:0000498 ! increased duration intersection_of: PATO:0000498 ! increased duration intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072741 ! protein localization to cell division site relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072741 ! protein localization to cell division site created_by: midori creation_date: 2013-08-27T14:26:10Z [Term] id: FYPO:0002528 name: decreased duration of protein localization to cell division site def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which a protein is localized to the cell division site for a shorter time than normal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased duration of protein localisation to cell division site" EXACT [PomBase:mah] synonym: "decreased duration of protein localization to cell division site during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased duration of protein localization to cell division site during vegetative growth" EXACT [PomBase:mah] synonym: "reduced duration of protein localization to cell division site" EXACT [PomBase:mah] is_a: FYPO:0001401 ! abnormal protein localization to cell division site is_a: PATO:0000499 ! decreased duration intersection_of: PATO:0000499 ! decreased duration intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072741 ! protein localization to cell division site relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072741 ! protein localization to cell division site created_by: midori creation_date: 2013-08-27T14:28:38Z [Term] id: FYPO:0002529 name: abnormal protein localization to nucleoplasm def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleoplasm is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found in the nucleoplasm and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to nucleoplasm" EXACT [PomBase:mah] synonym: "abnormal protein localization to nucleoplasm during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein localization to nucleoplasm during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001129 ! abnormal protein localization to nucleus during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1990173 ! protein localization to nucleoplasm intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1990173 ! protein localization to nucleoplasm relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-08-27T14:47:17Z [Term] id: FYPO:0002530 name: decreased protein localization to nucleoplasm def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleoplasm is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to nucleoplasm" EXACT [PomBase:mah] synonym: "decreased protein localization to nucleoplasm during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to nucleoplasm during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to nucleoplasm" EXACT [PomBase:mah] is_a: FYPO:0001514 ! decreased protein localization to nucleus during vegetative growth is_a: FYPO:0002529 ! abnormal protein localization to nucleoplasm intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990173 ! protein localization to nucleoplasm relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990173 ! protein localization to nucleoplasm created_by: midori creation_date: 2013-08-27T14:49:32Z [Term] id: FYPO:0002531 name: abolished protein localization to nucleoplasm def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleoplasm is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to nucleoplasm" EXACT [PomBase:mah] synonym: "abolished protein localization to nucleoplasm during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to nucleoplasm during vegetative growth" EXACT [PomBase:mah] synonym: "protein localization to nucleoplasm abolished" EXACT [PomBase:mah] is_a: FYPO:0001424 ! abolished protein localization to nucleus during vegetative growth is_a: FYPO:0002529 ! abnormal protein localization to nucleoplasm intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1990173 ! protein localization to nucleoplasm relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1990173 ! protein localization to nucleoplasm created_by: midori creation_date: 2013-08-27T14:49:53Z [Term] id: FYPO:0002532 name: delayed protein localization to nucleoplasm def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleoplasm begins later than normal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "delayed protein localisation to nucleoplasm" EXACT [PomBase:mah] synonym: "delayed protein localization to nucleoplasm during mitotic cell cycle" RELATED [PomBase:mah] synonym: "delayed protein localization to nucleoplasm during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002529 ! abnormal protein localization to nucleoplasm is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990173 ! protein localization to nucleoplasm relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990173 ! protein localization to nucleoplasm created_by: midori creation_date: 2013-08-27T14:53:26Z [Term] id: FYPO:0002533 name: abnormal protein localization to nucleoplasm during cellular response to hydrogen peroxide def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleoplasm is abnormal during a cellular response to hydrogen peroxide." [PomBase:mah] comment: Encompasses both presence of proteins not normally found in the nucleoplasm and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to nucleoplasm during cellular response to hydrogen peroxide" EXACT [PomBase:mah] synonym: "abnormal protein localization to nucleoplasm during cellular response to H2O2" EXACT [PomBase:mah] synonym: "abnormal protein localization to nucleoplasm during cellular response to hydrogen peroxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein localization to nucleoplasm during cellular response to hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002529 ! abnormal protein localization to nucleoplasm intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0070301 ! cellular response to hydrogen peroxide intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1990173 ! protein localization to nucleoplasm intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0070301 ! cellular response to hydrogen peroxide relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1990173 ! protein localization to nucleoplasm relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-08-27T14:54:05Z [Term] id: FYPO:0002534 name: abolished protein localization to nucleoplasm during cellular response to hydrogen peroxide def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleoplasm is abolished during a cellular response to hydrogen peroxide." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to nucleoplasm during cellular response to hydrogen peroxide" EXACT [PomBase:mah] synonym: "abolished protein localization to nucleoplasm during cellular response to H2O2" EXACT [PomBase:mah] synonym: "abolished protein localization to nucleoplasm during cellular response to hydrogen peroxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to nucleoplasm during cellular response to hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] synonym: "protein localization to nucleoplasm abolished during cellular response to hydrogen peroxide" EXACT [PomBase:mah] is_a: FYPO:0002531 ! abolished protein localization to nucleoplasm is_a: FYPO:0002533 ! abnormal protein localization to nucleoplasm during cellular response to hydrogen peroxide intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0070301 ! cellular response to hydrogen peroxide intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1990173 ! protein localization to nucleoplasm relationship: during GO:0070301 ! cellular response to hydrogen peroxide relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1990173 ! protein localization to nucleoplasm created_by: midori creation_date: 2013-08-27T14:54:27Z [Term] id: FYPO:0002535 name: decreased protein localization to nucleoplasm during cellular response to hydrogen peroxide def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleoplasm is decreased during a cellular response to hydrogen peroxide." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to nucleoplasm during cellular response to hydrogen peroxide" EXACT [PomBase:mah] synonym: "decreased protein localization to nucleoplasm during cellular response to H2O2" EXACT [PomBase:mah] synonym: "decreased protein localization to nucleoplasm during cellular response to hydrogen peroxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to nucleoplasm during cellular response to hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to nucleoplasm during cellular response to hydrogen peroxide" EXACT [PomBase:mah] is_a: FYPO:0002530 ! decreased protein localization to nucleoplasm is_a: FYPO:0002533 ! abnormal protein localization to nucleoplasm during cellular response to hydrogen peroxide is_a: FYPO:0004339 ! decreased protein localization to nucleus during cellular response to hydrogen peroxide intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0070301 ! cellular response to hydrogen peroxide intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990173 ! protein localization to nucleoplasm relationship: happens_during GO:0070301 ! cellular response to hydrogen peroxide relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990173 ! protein localization to nucleoplasm created_by: midori creation_date: 2013-08-27T14:54:56Z [Term] id: FYPO:0002536 name: delayed protein localization to nucleoplasm during cellular response to hydrogen peroxide def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleoplasm begins later than normal during a cellular response to hydrogen peroxide." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "delayed protein localisation to nucleoplasm during cellular response to hydrogen peroxide" EXACT [PomBase:mah] synonym: "delayed protein localization to nucleoplasm during cellular response to H2O2" EXACT [PomBase:mah] synonym: "delayed protein localization to nucleoplasm during cellular response to hydrogen peroxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "delayed protein localization to nucleoplasm during cellular response to hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002532 ! delayed protein localization to nucleoplasm is_a: FYPO:0002533 ! abnormal protein localization to nucleoplasm during cellular response to hydrogen peroxide is_a: FYPO:0003226 ! delayed protein localization to mitotic spindle intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0070301 ! cellular response to hydrogen peroxide intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990173 ! protein localization to nucleoplasm relationship: happens_during GO:0070301 ! cellular response to hydrogen peroxide relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990173 ! protein localization to nucleoplasm created_by: midori creation_date: 2013-08-27T14:55:11Z [Term] id: FYPO:0002537 name: abnormal protein localization to nucleoplasm during cellular response to hydroxyurea def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleoplasm is abnormal during a cellular response to hydroxyurea." [PomBase:mah] comment: Encompasses both presence of proteins not normally found in the nucleoplasm and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to nucleoplasm during cellular response to hydroxyurea" EXACT [PomBase:mah] synonym: "abnormal protein localization to nucleoplasm during cellular response to HU" EXACT [PomBase:mah] synonym: "abnormal protein localization to nucleoplasm during cellular response to hydroxyurea during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein localization to nucleoplasm during cellular response to hydroxyurea during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002529 ! abnormal protein localization to nucleoplasm intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: happens_during GO:0072711 ! cellular response to hydroxyurea intersection_of: inheres_in_part_of GO:1990173 ! protein localization to nucleoplasm intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: happens_during GO:0072711 ! cellular response to hydroxyurea relationship: inheres_in_part_of GO:1990173 ! protein localization to nucleoplasm relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-08-27T14:59:53Z [Term] id: FYPO:0002538 name: abolished protein localization to nucleoplasm during cellular response to hydroxyurea def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleoplasm is abolished during a cellular response to hydroxyurea." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to nucleoplasm during cellular response to hydroxyurea" EXACT [PomBase:mah] synonym: "abolished protein localization to nucleoplasm during cellular response to HU" EXACT [PomBase:mah] synonym: "abolished protein localization to nucleoplasm during cellular response to hydroxyurea during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to nucleoplasm during cellular response to hydroxyurea during vegetative growth" EXACT [PomBase:mah] synonym: "protein localization to nucleoplasm abolished during cellular response to hydroxyurea" EXACT [PomBase:mah] is_a: FYPO:0002531 ! abolished protein localization to nucleoplasm is_a: FYPO:0002537 ! abnormal protein localization to nucleoplasm during cellular response to hydroxyurea is_a: FYPO:0004188 ! abolished protein localization to nucleus during cellular response to hydroxyurea intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: during GO:0072711 ! cellular response to hydroxyurea intersection_of: towards GO:1990173 ! protein localization to nucleoplasm relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: during GO:0072711 ! cellular response to hydroxyurea relationship: towards GO:1990173 ! protein localization to nucleoplasm created_by: midori creation_date: 2013-08-27T15:00:01Z [Term] id: FYPO:0002539 name: delayed protein localization to nucleoplasm during cellular response to hydroxyurea def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleoplasm begins later than normal during a cellular response to hydroxyurea." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "delayed protein localisation to nucleoplasm during cellular response to hydroxyurea" EXACT [PomBase:mah] synonym: "delayed protein localization to nucleoplasm during cellular response to HU" EXACT [PomBase:mah] synonym: "delayed protein localization to nucleoplasm during cellular response to hydroxyurea during mitotic cell cycle" RELATED [PomBase:mah] synonym: "delayed protein localization to nucleoplasm during cellular response to hydroxyurea during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002532 ! delayed protein localization to nucleoplasm is_a: FYPO:0002537 ! abnormal protein localization to nucleoplasm during cellular response to hydroxyurea is_a: FYPO:0003226 ! delayed protein localization to mitotic spindle intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: happens_during GO:0072711 ! cellular response to hydroxyurea intersection_of: inheres_in GO:1990173 ! protein localization to nucleoplasm relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: happens_during GO:0072711 ! cellular response to hydroxyurea relationship: inheres_in GO:1990173 ! protein localization to nucleoplasm created_by: midori creation_date: 2013-08-27T15:00:08Z [Term] id: FYPO:0002540 name: decreased protein localization to nucleoplasm during cellular response to hydroxyurea def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleoplasm is decreased during a cellular response to hydroxyurea." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to nucleoplasm during cellular response to hydroxyurea" EXACT [PomBase:mah] synonym: "decreased protein localization to nucleoplasm during cellular response to HU" EXACT [PomBase:mah] synonym: "decreased protein localization to nucleoplasm during cellular response to hydroxyurea during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to nucleoplasm during cellular response to hydroxyurea during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to nucleoplasm during cellular response to hydroxyurea" EXACT [PomBase:mah] is_a: FYPO:0002530 ! decreased protein localization to nucleoplasm is_a: FYPO:0002537 ! abnormal protein localization to nucleoplasm during cellular response to hydroxyurea intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: happens_during GO:0072711 ! cellular response to hydroxyurea intersection_of: inheres_in GO:1990173 ! protein localization to nucleoplasm relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: happens_during GO:0072711 ! cellular response to hydroxyurea relationship: inheres_in GO:1990173 ! protein localization to nucleoplasm created_by: midori creation_date: 2013-08-27T15:05:15Z [Term] id: FYPO:0002541 name: increased protein localization to nucleoplasm def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleoplasm is increased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to nucleoplasm" EXACT [PomBase:mah] synonym: "increased protein localization to nucleoplasm during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein localization to nucleoplasm during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001130 ! increased protein localization to nucleus during vegetative growth is_a: FYPO:0002529 ! abnormal protein localization to nucleoplasm intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990173 ! protein localization to nucleoplasm relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990173 ! protein localization to nucleoplasm created_by: midori creation_date: 2013-08-27T15:07:25Z [Term] id: FYPO:0002542 name: decreased protein threonine phosphorylation at Thr-Pro site during cellular response to hydrogen peroxide def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of threonine residues N-terminal to proline residues (i.e. in Thr-Pro sequences) occurs to a lower extent than normal during a cellular response to hydrogen peroxide." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein threonine phosphorylation at Thr-Pro site during cellular response to H2O2" EXACT [PomBase:mah] synonym: "decreased protein threonine phosphorylation at threonine-proline site during cellular response to hydrogen peroxide" EXACT [PomBase:mah] synonym: "decreased protein threonine phosphorylation at TP site during cellular response to hydrogen peroxide" EXACT [PomBase:mah] synonym: "reduced protein threonine phosphorylation at Thr-Pro site during cellular response to hydrogen peroxide" EXACT [PomBase:mah] is_a: FYPO:0002645 ! decreased protein threonine phosphorylation is_a: FYPO:0004794 ! decreased protein phosphorylation at Ser/Thr-Pro site created_by: midori creation_date: 2013-08-27T15:19:31Z [Term] id: FYPO:0002543 name: decreased protein threonine phosphorylation at Thr-Pro site during cellular response to hydroxyurea def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of threonine residues N-terminal to proline residues (i.e. in Thr-Pro sequences) occurs to a lower extent than normal during a cellular response to hydroxyurea." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein threonine phosphorylation at Thr-Pro site during cellular response to HU" EXACT [PomBase:mah] synonym: "decreased protein threonine phosphorylation at threonine-proline site during cellular response to hydroxyurea" EXACT [PomBase:mah] synonym: "decreased protein threonine phosphorylation at TP site during cellular response to hydroxyurea" EXACT [PomBase:mah] synonym: "reduced protein threonine phosphorylation at Thr-Pro site during cellular response to hydroxyurea" EXACT [PomBase:mah] is_a: FYPO:0002645 ! decreased protein threonine phosphorylation is_a: FYPO:0004794 ! decreased protein phosphorylation at Ser/Thr-Pro site created_by: midori creation_date: 2013-08-27T15:22:07Z [Term] id: FYPO:0002544 name: abolished protein serine phosphorylation at RxxS site during cellular response to hydrogen peroxide def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of serine residues three positions C-terminal to arginine residues (i.e. in Arg-X-X-Ser, or RxxS, sequences) does not occur during a cellular response to hydrogen peroxide." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein serine phosphorylation at Arg-X-X-Ser site during cellular response to hydrogen peroxide" EXACT [PomBase:mah] synonym: "abolished protein serine phosphorylation at arginine-X-X-serine site during cellular response to hydrogen peroxide" EXACT [PomBase:mah] synonym: "abolished protein serine phosphorylation at RxxS site during cellular response to H2O2" EXACT [PomBase:mah] synonym: "protein serine phosphorylation abolished at RxxS site during cellular response to hydrogen peroxide" EXACT [PomBase:mah] is_a: FYPO:0002982 ! abolished protein serine phosphorylation during vegetative growth created_by: midori creation_date: 2013-08-27T15:23:47Z [Term] id: FYPO:0002545 name: abolished protein serine phosphorylation at RxxS site during cellular response to hydroxyurea def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of serine residues three positions C-terminal to arginine residues (i.e. in Arg-X-X-Ser, or RxxS, sequences) does not occur during a cellular response to hydroxyurea." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein serine phosphorylation at Arg-X-X-Ser site during cellular response to hydroxyurea" EXACT [PomBase:mah] synonym: "abolished protein serine phosphorylation at arginine-X-X-serine site during cellular response to hydroxyurea" EXACT [PomBase:mah] synonym: "abolished protein serine phosphorylation at RxxS site during cellular response to HU" EXACT [PomBase:mah] synonym: "protein serine phosphorylation abolished at RxxS site during cellular response to hydroxyurea" EXACT [PomBase:mah] is_a: FYPO:0002982 ! abolished protein serine phosphorylation during vegetative growth created_by: midori creation_date: 2013-08-27T15:26:39Z [Term] id: FYPO:0002546 name: sensitive to trichostatin A def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to trichostatin A. Cells stop growing (and may die) at a concentration of trichostatin A that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to trichostatin A" EXACT [PomBase:mah] synonym: "sensitive to trichostatin A during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to trichostatin A during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:46024 ! trichostatin A relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:46024 ! trichostatin A created_by: midori creation_date: 2013-08-27T15:41:53Z [Term] id: FYPO:0002547 name: sensitive to nicotinamide def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to nicotinamide. Cells stop growing (and may die) at a concentration of nicotinamide that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to nicotinamide" EXACT [PomBase:mah] synonym: "sensitive to nicotinamide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to nicotinamide during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:17154 ! nicotinamide relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:17154 ! nicotinamide created_by: midori creation_date: 2013-08-27T15:42:25Z [Term] id: FYPO:0002548 name: increased cellular 4'-phosphopantothenate level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of 4'-phosphopantothenate measured in a cell is higher than normal." [PomBase:mah] synonym: "increased 4'-phosphopantothenate accumulation" RELATED [PomBase:mah] synonym: "increased cellular 4'-phosphopantothenate level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular 4'-phosphopantothenate level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:10986 ! (R)-4'-phosphonatopantothenate(3-) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:10986 ! (R)-4'-phosphonatopantothenate(3-) created_by: midori creation_date: 2013-08-27T15:45:17Z [Term] id: FYPO:0002549 name: sensitive to stress def: "A phenotype in which cells in a population show increased sensitivity to a stress. Typically, a cell population are deemed sensitive to a stress if cells in the population stop growing (and may die) when exposed to the stress at an intensity that allows a population of wild type cells to grow and divide." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. Use a descendant of this term if you have assayed growth of cells exposed to a stress in culture. If you have assayed the response to the stress at the subcellular or molecular level, consider annotating to a descendant of 'abnormal cellular response to stress' (FYPO:0000162). subset: qc_do_not_manually_annotate synonym: "hypersensitive to stress" EXACT [PomBase:mah] synonym: "stress resistance: decreased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000139 ! cell population growth phenotype created_by: midori creation_date: 2013-08-27T15:46:35Z [Term] id: FYPO:0002550 name: sensitive to UV def: "A cell phenotype in which cells show increased sensitivity to ultraviolet light." [PomBase:mah] synonym: "hypersensitive to UV" EXACT [PomBase:mah] synonym: "increased sensitivity to UV irradiation" EXACT [PomBase:vw] synonym: "sensitive to ultraviolet light" EXACT [PomBase:mah] synonym: "UV resistance: decreased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0002549 ! sensitive to stress created_by: midori creation_date: 2013-08-27T15:48:41Z [Term] id: FYPO:0002551 name: sensitive to UV during G0 def: "A cell phenotype in which cells show increased sensitivity to ultraviolet light during G0 phase." [PomBase:mah] synonym: "hypersensitive to UV during G0" EXACT [PomBase:mah] synonym: "increased sensitivity to UV irradiation during G0" EXACT [PomBase:vw] synonym: "sensitive to ultraviolet light during G0" EXACT [PomBase:mah] synonym: "sensitive to UV during cellular quiescence" RELATED [PomBase:mah] is_a: FYPO:0002550 ! sensitive to UV created_by: midori creation_date: 2013-08-27T15:50:17Z [Term] id: FYPO:0002552 name: lipid particles present in decreased numbers def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells contain fewer lipid particles than normal." [PomBase:mah] synonym: "decreased level of lipid particles" RELATED [PomBase:al] synonym: "decreased lipid particle formation during vegetative growth" RELATED [PomBase:mah] synonym: "fewer lipid particles present during vegetative growth" EXACT [PomBase:mah] synonym: "lipid droplets present in decreased numbers" EXACT [GO:0005811, PomBase:mah] synonym: "lipid particles present in decreased numbers during mitotic cell cycle" RELATED [PomBase:mah] synonym: "lipid particles present in decreased numbers during vegetative growth" EXACT [PomBase:mah] synonym: "lipid particles present in reduced numbers" EXACT [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: PATO:0002001 ! has fewer parts of type intersection_of: PATO:0002001 ! has fewer parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0005811 ! lipid particle relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0005811 ! lipid particle created_by: midori creation_date: 2013-08-27T15:53:30Z [Term] id: FYPO:0002553 name: abnormal double-strand break processing def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which double-strand break processing is abnormal. Double-strand break processing is the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang." [GO:0000729, PomBase:mah] synonym: "abnormal double-strand break processing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal double-strand break processing during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal DSB processing" EXACT [PomBase:vw] is_a: FYPO:0000777 ! abnormal double-strand break repair intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000729 ! DNA double-strand break processing intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000729 ! DNA double-strand break processing relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-08-28T10:34:04Z [Term] id: FYPO:0002554 name: normal protein localization to site of double-strand break def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to a region of a chromosome at which a DNA double-strand break has occurred is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to site of double-strand break" EXACT [PomBase:mah] synonym: "normal protein localization to double-strand break site" EXACT [PomBase:mah] synonym: "normal protein localization to DSB" EXACT [PomBase:vw] synonym: "normal protein localization to site of double-strand break during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to site of double-strand break during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein localization to site of DSB" EXACT [PomBase:mah] is_a: FYPO:0000644 ! normal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990166 ! protein localization to site of double-strand break intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990166 ! protein localization to site of double-strand break relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-08-28T10:40:47Z [Term] id: FYPO:0002555 name: abolished protein localization to medial cortex during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the medial cortex of a cell is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to medial cortex during vegetative growth" EXACT [GO:0071574, PomBase:mah] synonym: "abolished protein localization to medial cortex during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to medial ring during vegetative growth" EXACT [GO:0031097, GO:0071574] synonym: "protein localization to medial cortex abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000731 ! abnormal protein localization to medial cortex during vegetative growth is_a: FYPO:0000930 ! abolished protein localization to cell cortex is_a: FYPO:0001371 ! abolished protein localization to medial cortex is_a: FYPO:0001880 ! abolished protein localization to cell division site intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0071574 ! protein localization to medial cortex relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0071574 ! protein localization to medial cortex created_by: midori creation_date: 2013-08-28T11:26:06Z [Term] id: FYPO:0002556 name: abolished protein localization to medial cortex during vegetative growth, with protein distributed in non-growing half of cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the medial cortex of a cell is abolished, and the protein is instead detected distributed throughout the half of the cell nearer the non-growing end." [PomBase:al, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to medial cortex during vegetative growth" EXACT [PomBase:mah] synonym: "abolished protein localization to medial cortex during vegetative growth, with protein distributed in non-growing half of cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to medial ring during vegetative growth" EXACT [GO:0031097, GO:0071574] synonym: "protein localization to medial cortex abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002555 ! abolished protein localization to medial cortex during vegetative growth created_by: midori creation_date: 2013-08-28T11:29:01Z [Term] id: FYPO:0002557 name: decreased protein localization to medial cortex during vegetative growth def: "A cell phenotype in which the localization of a protein to the medial cortex is decreased in the vegetative growth phase of the life cycle." [PomBase:mah] comment: Encompasses both presence of proteins not normally found at the medial cortex and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to medial cortex during vegetative growth" EXACT [GO:0071574, PomBase:mah] synonym: "decreased protein localization to medial cortex during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to medial ring during vegetative growth" EXACT [GO:0031097, GO:0071574] synonym: "reduced protein localization to medial cortex during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000731 ! abnormal protein localization to medial cortex during vegetative growth is_a: FYPO:0000929 ! decreased protein localization to cell cortex is_a: FYPO:0002869 ! decreased protein localization to cell division site intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071574 ! protein localization to medial cortex relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071574 ! protein localization to medial cortex created_by: midori creation_date: 2013-08-28T11:31:22Z [Term] id: FYPO:0002558 name: normal protein localization to medial cortex during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the medial cortex is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to medial cortex during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein localization to medial cortex during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to medial ring during vegetative growth" EXACT [GO:0031097, GO:0071574] is_a: FYPO:0001402 ! normal protein localization to cell cortex is_a: FYPO:0002442 ! normal protein localization to cell division site intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071574 ! protein localization to medial cortex intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071574 ! protein localization to medial cortex relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-08-28T11:32:40Z [Term] id: FYPO:0002559 name: normal protein localization to actomyosin contractile ring def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the actomyosin contractile ring is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to actomyosin contractile ring" EXACT [PomBase:mah] synonym: "normal protein localization to actomyosin contractile ring during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to actomyosin contractile ring during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein localization to actomyosin contractile ring involved in mitotic cytokinesis" EXACT [GO:1904498] synonym: "normal protein localization to contractile ring" EXACT [PomBase:al] synonym: "normal protein localization to cytokinetic contractile ring" EXACT [PomBase:vw] synonym: "normal protein localization to mitotic contractile ring" EXACT [PomBase:vw] is_a: FYPO:0001402 ! normal protein localization to cell cortex is_a: FYPO:0002442 ! normal protein localization to cell division site is_a: FYPO:0003441 ! normal protein localization to actin cytoskeleton intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1904498 ! protein localization to actomyosin contractile ring involved in mitotic cytokinesis intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1904498 ! protein localization to actomyosin contractile ring involved in mitotic cytokinesis relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-08-28T11:41:22Z [Term] id: FYPO:0002560 name: abnormal protein localization to actomyosin contractile ring def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the actomyosin contractile ring is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found at the centromere and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to actomyosin contractile ring" EXACT [PomBase:mah] synonym: "abnormal protein localization to actomyosin contractile ring during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein localization to actomyosin contractile ring during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal protein localization to actomyosin contractile ring involved in mitotic cytokinesis" EXACT [GO:1904498] synonym: "abnormal protein localization to contractile ring" EXACT [PomBase:al] synonym: "abnormal protein localization to cytokinetic contractile ring" EXACT [PomBase:vw] synonym: "abnormal protein localization to mitotic contractile ring" EXACT [PomBase:vw] is_a: FYPO:0000928 ! abnormal protein localization to cell cortex is_a: FYPO:0001401 ! abnormal protein localization to cell division site intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1904498 ! protein localization to actomyosin contractile ring involved in mitotic cytokinesis intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1904498 ! protein localization to actomyosin contractile ring involved in mitotic cytokinesis relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-08-28T11:43:36Z [Term] id: FYPO:0002561 name: abolished protein localization to actomyosin contractile ring def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the actomyosin contractile ring is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to actomyosin contractile ring" EXACT [PomBase:mah] synonym: "abolished protein localization to actomyosin contractile ring during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to actomyosin contractile ring during vegetative growth" EXACT [PomBase:mah] synonym: "abolished protein localization to actomyosin contractile ring involved in mitotic cytokinesis" EXACT [GO:1904498] synonym: "abolished protein localization to contractile ring" EXACT [PomBase:al] synonym: "abolished protein localization to cytokinetic contractile ring" EXACT [PomBase:vw] synonym: "abolished protein localization to mitotic contractile ring" EXACT [PomBase:vw] synonym: "protein localization to actomyosin contractile ring abolished" EXACT [PomBase:mah] is_a: FYPO:0000930 ! abolished protein localization to cell cortex is_a: FYPO:0001880 ! abolished protein localization to cell division site is_a: FYPO:0002560 ! abnormal protein localization to actomyosin contractile ring intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1904498 ! protein localization to actomyosin contractile ring involved in mitotic cytokinesis relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1904498 ! protein localization to actomyosin contractile ring involved in mitotic cytokinesis created_by: midori creation_date: 2013-08-28T11:43:43Z [Term] id: FYPO:0002562 name: delayed protein localization to actomyosin contractile ring def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the actomyosin contractile ring begins later than normal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "delayed protein localisation to actomyosin contractile ring" EXACT [PomBase:mah] synonym: "delayed protein localization to actomyosin contractile ring during mitotic cell cycle" RELATED [PomBase:mah] synonym: "delayed protein localization to actomyosin contractile ring during vegetative growth" EXACT [PomBase:mah] synonym: "delayed protein localization to actomyosin contractile ring involved in mitotic cytokinesis" EXACT [GO:1904498] synonym: "delayed protein localization to contractile ring" EXACT [PomBase:al] synonym: "delayed protein localization to cytokinetic contractile ring" EXACT [PomBase:vw] synonym: "delayed protein localization to mitotic contractile ring" EXACT [PomBase:vw] is_a: FYPO:0002560 ! abnormal protein localization to actomyosin contractile ring is_a: FYPO:0003946 ! delayed protein localization to cell division site intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1904498 ! protein localization to actomyosin contractile ring involved in mitotic cytokinesis relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1904498 ! protein localization to actomyosin contractile ring involved in mitotic cytokinesis created_by: midori creation_date: 2013-08-28T11:44:12Z [Term] id: FYPO:0002563 name: normal protein localization to nuclear periphery def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nuclear periphery is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to nuclear periphery" EXACT [PomBase:mah] synonym: "normal protein localization to nuclear periphery during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to nuclear periphery during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000838 ! normal protein localization to nucleus intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990139 ! protein localization to nuclear periphery intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990139 ! protein localization to nuclear periphery relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-08-28T11:48:40Z [Term] id: FYPO:0002564 name: increased tRNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of transfer RNA (tRNA) measured in a cell is higher than normal. Total tRNA or a specific tRNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased mature tRNA level" EXACT [SO:0000253] synonym: "increased transfer RNA level" EXACT [PomBase:mah] synonym: "increased tRNA accumulation" RELATED [PomBase:mah] synonym: "increased tRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased tRNA level during vegetative growth" EXACT [PomBase:mah] synonym: "increased tRNA transcript level" EXACT [PomBase:vw] is_a: FYPO:0000825 ! increased RNA level during vegetative growth is_a: FYPO:0002579 ! altered tRNA level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards SO:0000253 ! tRNA relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards SO:0000253 ! tRNA created_by: midori creation_date: 2013-08-28T13:48:20Z [Term] id: FYPO:0002565 name: abolished histone methylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone methylation does not occur. All histone methylation may be affected, or methylation of specific sites on specific histones may be abolished." [PomBase:mah] synonym: "abolished histone methylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished histone methylation during vegetative growth" EXACT [PomBase:mah] synonym: "histone methylation abolished" EXACT [PomBase:mah] synonym: "histone methylation absent" EXACT [PomBase:al] is_a: FYPO:0000457 ! abnormal histone methylation is_a: FYPO:0000544 ! abolished protein modification during vegetative growth intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0016571 ! histone methylation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0016571 ! histone methylation created_by: midori creation_date: 2013-08-28T13:54:16Z [Term] id: FYPO:0002566 name: abolished histone H3-K9 methylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which methylation of lysine at position 9 of histone H3 does not occur." [PomBase:mah] synonym: "abolished histone H3 K9 methylation" EXACT [GO:0051567, PomBase:mah] synonym: "abolished histone H3-K9 methylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished histone H3-K9 methylation during vegetative growth" EXACT [PomBase:mah] synonym: "abolished histone H3K9me" EXACT [GO:0051567, PomBase:mah] synonym: "abolished histone lysine H3 K9 methylation" EXACT [GO:0051567, PomBase:mah] synonym: "histone H3-K9 methylation abolished" EXACT [PomBase:mah] synonym: "histone H3-K9 methylation absent" EXACT [PomBase:al] is_a: FYPO:0000458 ! abnormal histone H3-K9 methylation is_a: FYPO:0002565 ! abolished histone methylation is_a: FYPO:0004488 ! abolished protein lysine methylation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0051567 ! histone H3-K9 methylation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0051567 ! histone H3-K9 methylation created_by: midori creation_date: 2013-08-28T13:56:00Z [Term] id: FYPO:0002567 name: normal centromeric outer repeat transcript level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNAs transcribed from the centromere outer repeat region measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: This term encompasses both unprocessed RNA transcribed from the centromere outer repeat region and siRNAs derived by dicer-mediated processing of the primary transcripts. Use this term only for levels of RNA transcribed from endogenous centromere outer repeat sequences. synonym: "normal accumulation of centromeric outer repeat transcripts" RELATED [PomBase:mah] synonym: "normal accumulation of centromeric outer repeat transcripts during vegetative growth" EXACT [PomBase:mah] synonym: "normal accumulation of non-coding outer repeat transcripts" EXACT [PomBase:vw] synonym: "normal centromeric outer repeat transcript accumulation" RELATED [PomBase:mah] synonym: "normal centromeric outer repeat transcript level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal centromeric outer repeat transcript level during vegetative growth" EXACT [PomBase:mah] synonym: "normal level of centromeric outer repeat transcripts" EXACT [PomBase:al] is_a: FYPO:0001317 ! normal RNA level during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards SO:0001905 ! regional_centromere_outer_repeat_transcript relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards SO:0001905 ! regional_centromere_outer_repeat_transcript created_by: midori creation_date: 2013-08-28T14:38:37Z [Term] id: FYPO:0002568 name: abolished protein localization to nuclear periphery def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nuclear periphery is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to nuclear periphery" EXACT [PomBase:mah] synonym: "abolished protein localization to nuclear periphery during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to nuclear periphery during vegetative growth" EXACT [PomBase:mah] synonym: "protein localization to nuclear periphery abolished" EXACT [PomBase:mah] is_a: FYPO:0001424 ! abolished protein localization to nucleus during vegetative growth is_a: FYPO:0002338 ! abnormal protein localization to nuclear periphery intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1990139 ! protein localization to nuclear periphery relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1990139 ! protein localization to nuclear periphery created_by: midori creation_date: 2013-08-28T14:45:05Z [Term] id: FYPO:0002569 name: increased cellular dCTP level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of dCTP measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular dCTP level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular dCTP level during vegetative growth" EXACT [PomBase:mah] synonym: "increased dCTP accumulation" RELATED [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:16311 ! dCTP relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:16311 ! dCTP created_by: midori creation_date: 2013-08-28T14:52:37Z [Term] id: FYPO:0002570 name: increased cellular dATP level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of dATP measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular dATP level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular dATP level during vegetative growth" EXACT [PomBase:mah] synonym: "increased dATP accumulation" RELATED [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:16284 ! dATP relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:16284 ! dATP created_by: midori creation_date: 2013-08-28T14:53:33Z [Term] id: FYPO:0002571 name: decreased cellular dGTP level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of dGTP measured in the cell is lower than normal." [PomBase:mah] synonym: "decreased cellular dGTP level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular dGTP level during vegetative growth" EXACT [PomBase:mah] synonym: "reduced cellular dGTP level" EXACT [PomBase:mah] is_a: FYPO:0001329 ! decreased level of substance in cell during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:16497 ! dGTP relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:16497 ! dGTP created_by: midori creation_date: 2013-08-28T14:54:51Z [Term] id: FYPO:0002572 name: decreased cellular dTTP level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of dTTP measured in the cell is lower than normal." [PomBase:mah] synonym: "decreased cellular dTTP level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular dTTP level during vegetative growth" EXACT [PomBase:mah] synonym: "reduced cellular dTTP level" EXACT [PomBase:mah] is_a: FYPO:0001329 ! decreased level of substance in cell during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:18077 ! dTTP relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:18077 ! dTTP created_by: midori creation_date: 2013-08-28T14:56:01Z [Term] id: FYPO:0002573 name: increased number of Ssb1 foci def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the number of sites at which the protein Ssb1 accumulates is greater than normal." [PMID:22927644, PomBase:mah] synonym: "increased number of Rad11 foci" EXACT [PMID:22927644] synonym: "increased number of RPA foci" EXACT [PMID:22927644] synonym: "increased number of Rpa1 foci" EXACT [PMID:22927644] synonym: "increased number of Ssb1 foci during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased number of Ssb1 foci during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001321 ! cellular physical quality phenotype during vegetative growth created_by: midori creation_date: 2013-08-28T15:01:41Z [Term] id: FYPO:0002574 name: normal protein localization to centromere def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the centromere of a chromosome is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to centromere" EXACT [PomBase:mah] synonym: "normal protein localisation to chromosome, centromeric region" EXACT [GO:0071459, PomBase:mah] synonym: "normal protein localization to centromere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to centromere during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein localization to chromosome, centric region" EXACT [GO:0071459, PomBase:mah] synonym: "normal protein localization to chromosome, centromeric region" EXACT [GO:0071459, PomBase:mah] is_a: FYPO:0000644 ! normal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071459 ! protein localization to chromosome, centromeric region intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071459 ! protein localization to chromosome, centromeric region relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-08-28T15:10:06Z [Term] id: FYPO:0002575 name: normal protein localization to chromosome at long terminal repeat def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein a region in a chromosome that contains one or more long terminal repeats (LTRs) is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to chromosome at long terminal repeat" EXACT [PomBase:mah] synonym: "normal protein localization to chromosome at long terminal repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to chromosome at long terminal repeat during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein localization to chromosome at LTR" EXACT [PomBase:mah] synonym: "normal protein localization to LTR" EXACT [PomBase:al] is_a: FYPO:0000644 ! normal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034502 ! protein localization to chromosome intersection_of: occurs_at SO:0000286 ! long_terminal_repeat intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034502 ! protein localization to chromosome relationship: occurs_at SO:0000286 ! long_terminal_repeat relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-08-28T15:14:19Z [Term] id: FYPO:0002576 name: abnormal chromatin binding def: "A molecular function phenotype in which the occurrence of chromatin binding by a gene product (usually a protein) in a mutant is abnormal. The affected gene product may be encoded by the mutated gene, or by a different gene, and may normally bind DNA, protein, or both in chromatin." [PomBase:mah] is_a: FYPO:0000707 ! abnormal molecular function is_a: FYPO:0001092 ! binding phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0003682 ! chromatin binding intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0003682 ! chromatin binding relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-08-28T15:21:27Z [Term] id: FYPO:0002577 name: decreased chromatin binding def: "A molecular function phenotype in which occurrence of chromatin binding by a gene product (usually a protein) in a mutant is decreased. The affected gene product may be encoded by the mutated gene, or by a different gene, and may normally bind DNA, protein, or both in chromatin." [PomBase:mah] synonym: "reduced chromatin binding" EXACT [PomBase:mah] is_a: FYPO:0002576 ! abnormal chromatin binding is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0003682 ! chromatin binding relationship: inheres_in GO:0003682 ! chromatin binding created_by: midori creation_date: 2013-08-28T15:21:38Z [Term] id: FYPO:0002578 name: resistance to hydroxyurea def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of hydroxyurea than normal." [PomBase:mah] synonym: "resistance to HU" EXACT [PomBase:mah] synonym: "resistance to hydroxyurea during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to hydroxyurea during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to hydroxyurea" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:44423 ! hydroxyurea relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:44423 ! hydroxyurea created_by: midori creation_date: 2013-08-28T15:27:26Z [Term] id: FYPO:0002579 name: altered tRNA level during vegetative growth def: "A cell phenotype in which the amount of transfer RNA (tRNA) measured in a cell differs from normal when the cell is in the vegetative growth phase of the life cycle. Total tRNA or a specific tRNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "abnormal tRNA level during vegetative growth" EXACT [PomBase:mah] synonym: "altered cellular transfer RNA level during vegetative growth" EXACT [PomBase:mah] synonym: "altered cellular tRNA level during vegetative growth" EXACT [PomBase:mah] synonym: "altered tRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "altered tRNA transcript level during vegetative growth" EXACT [PomBase:vw] is_a: FYPO:0001326 ! altered RNA level during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards SO:0000253 ! tRNA relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000460 ! abnormal relationship: towards SO:0000253 ! tRNA created_by: midori creation_date: 2013-08-28T16:07:23Z [Term] id: FYPO:0002580 name: normal tRNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of transfer RNA measured in a cell is normal (i.e. indistinguishable from wild type). Total tRNA or a specific tRNA may be measured." [PomBase:mah] comment: We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "normal mature tRNA level" EXACT [SO:0000253] synonym: "normal transfer RNA level" EXACT [PomBase:mah] synonym: "normal tRNA accumulation" RELATED [PomBase:mah] synonym: "normal tRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal tRNA level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001317 ! normal RNA level during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards SO:0000253 ! tRNA relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards SO:0000253 ! tRNA created_by: midori creation_date: 2013-08-28T16:11:10Z [Term] id: FYPO:0002581 name: increased level of nuclear tRNA processing intermediates with 3' extensions def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of any tRNA processing intermediates with 3' extensions measured in the nucleus is higher than normal." [PomBase:mah] synonym: "increased accumulation of nuclear tRNA processing intermediates with 3' extensions" RELATED [PomBase:al] synonym: "increased level of nuclear tRNA processing intermediates with 3' extensions during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased level of nuclear tRNA processing intermediates with 3' extensions during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000825 ! increased RNA level during vegetative growth created_by: midori creation_date: 2013-08-28T16:12:36Z [Term] id: FYPO:0002582 name: normal mitochondrial tRNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of mitochondrial transfer RNA measured in a cell is normal (i.e. indistinguishable from wild type). Total tRNA or a specific tRNA may be measured." [PomBase:mah] comment: We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "normal mature mitochondrial tRNA level" EXACT [SO:0000253] synonym: "normal mitochondrial transfer RNA level" EXACT [PomBase:mah] synonym: "normal mitochondrial tRNA accumulation" RELATED [PomBase:mah] synonym: "normal mitochondrial tRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal mitochondrial tRNA level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001313 ! normal subcellular component during vegetative growth is_a: FYPO:0002580 ! normal tRNA level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005739 ! mitochondrion intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards SO:0000253 ! tRNA relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005739 ! mitochondrion relationship: qualifier PATO:0000461 ! normal relationship: towards SO:0000253 ! tRNA created_by: midori creation_date: 2013-08-28T16:18:45Z [Term] id: FYPO:0002583 name: decreased tRNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of transfer RNA (tRNA) measured in a cell is lower than normal. Total tRNA or a specific tRNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased mature tRNA level" EXACT [SO:0000253] synonym: "decreased transfer RNA level" EXACT [PomBase:mah] synonym: "decreased tRNA accumulation" RELATED [PomBase:mah] synonym: "decreased tRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased tRNA level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased tRNA transcript level" EXACT [PomBase:vw] synonym: "reduced tRNA level" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth is_a: FYPO:0002579 ! altered tRNA level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards SO:0000253 ! tRNA relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards SO:0000253 ! tRNA created_by: midori creation_date: 2013-08-28T16:20:19Z [Term] id: FYPO:0002584 name: decreased mitochondrial tRNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of mitochondrial transfer RNA (tRNA) measured in a cell is lower than normal. Total tRNA or a specific tRNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased mature mitochondrial tRNA level" EXACT [SO:0000253] synonym: "decreased mitochondrial transfer RNA level" EXACT [PomBase:mah] synonym: "decreased mitochondrial tRNA accumulation" RELATED [PomBase:mah] synonym: "decreased mitochondrial tRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased mitochondrial tRNA level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased mitochondrial tRNA transcript level" EXACT [PomBase:vw] synonym: "reduced mitochondrial tRNA level" EXACT [PomBase:mah] is_a: FYPO:0002583 ! decreased tRNA level is_a: FYPO:0003423 ! decreased mitochondrial RNA level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005739 ! mitochondrion intersection_of: towards SO:0000253 ! tRNA relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005739 ! mitochondrion relationship: towards SO:0000253 ! tRNA created_by: midori creation_date: 2013-08-28T16:22:12Z [Term] id: FYPO:0002585 name: mitochondrial tRNA absent from cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of mitochondrial transfer RNA (tRNA) measured in a cell is too low to detect. Total tRNA or a specific tRNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "mature mitochondrial tRNA absent from cell" EXACT [SO:0000253] synonym: "mitochondrial transfer RNA absent from cell" EXACT [PomBase:mah] synonym: "mitochondrial tRNA absent from cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "mitochondrial tRNA absent from cell during vegetative growth" EXACT [PomBase:mah] synonym: "mitochondrial tRNA transcripts absent from cell" EXACT [PomBase:vw] synonym: "undetectable mitochondrial tRNA level" EXACT [PomBase:mah] is_a: FYPO:0002584 ! decreased mitochondrial tRNA level is_a: FYPO:0003161 ! RNA absent from cell during vegetative growth intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005739 ! mitochondrion intersection_of: towards SO:0000253 ! tRNA relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005739 ! mitochondrion relationship: towards SO:0000253 ! tRNA created_by: midori creation_date: 2013-08-28T16:24:01Z [Term] id: FYPO:0002586 name: normal mitochondrial tRNA 3'-end processing def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitochondrial tRNA 3'-end processing is normal (i.e. indistinguishable from wild type). In mitochondrial tRNA 3'-end processing, the 3' end of a mitochondrial pre-tRNA molecule is converted to that of a mature mitochondrial tRNA." [GO:0006396, PomBase:mah] synonym: "normal mitochondrial tRNA 3'-end processing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal mitochondrial tRNA 3'-end processing during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001980 ! normal RNA processing intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990180 ! mitochondrial tRNA 3'-end processing intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990180 ! mitochondrial tRNA 3'-end processing relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-08-28T16:27:04Z [Term] id: FYPO:0002587 name: increased level of mitochondrial polycistronic RNA precursors def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of any mitochondrially-encoded polycistronic RNA precursors measured in the cell is higher than normal." [PomBase:mah] synonym: "increased accumulation of mitochondrial polycistronic RNA precursors" RELATED [PomBase:al] synonym: "increased level of mitochondrial polycistronic RNA precursors during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased level of mitochondrial polycistronic RNA precursors during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000825 ! increased RNA level during vegetative growth created_by: midori creation_date: 2013-08-28T16:30:56Z [Term] id: FYPO:0002588 name: resistance to nickel def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of nickel ions than normal." [PomBase:mah] synonym: "resistance to nickel during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to nickel during vegetative growth" EXACT [PomBase:mah] synonym: "resistance to nickel ion" EXACT [PomBase:mah] synonym: "resistant to nickel" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:25516 ! nickel cation relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:25516 ! nickel cation created_by: midori creation_date: 2013-08-28T16:35:20Z [Term] id: FYPO:0002589 name: resistance to zinc def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of zinc ions than normal." [PomBase:mah] synonym: "resistance to zinc during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to zinc during vegetative growth" EXACT [PomBase:mah] synonym: "resistance to zinc ion" EXACT [PomBase:mah] synonym: "resistant to nickel" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:27365 ! zinc ion relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:27365 ! zinc ion created_by: midori creation_date: 2013-08-28T16:35:56Z [Term] id: FYPO:0002590 name: increased level of mitochondrial tRNA processing intermediates with 3' extensions def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of any tRNA processing intermediates with 3' extensions measured in the mitochondria is higher than normal." [PomBase:mah] synonym: "increased accumulation of mitochondrial tRNA processing intermediates with 3' extensions" RELATED [PomBase:al] synonym: "increased level of mitochondrial tRNA processing intermediates with 3' extensions during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased level of mitochondrial tRNA processing intermediates with 3' extensions during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000825 ! increased RNA level during vegetative growth created_by: midori creation_date: 2013-08-29T16:55:19Z [Term] id: FYPO:0002591 name: abnormal histone phosphorylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone phosphorylation is abnormal. All histone phosphorylation may be affected, or phosphorylation of specific sites on specific histones may be altered." [PomBase:mah] synonym: "abnormal histone phosphorylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal histone phosphorylation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000330 ! abnormal histone modification is_a: FYPO:0000775 ! abnormal protein phosphorylation during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0016572 ! histone phosphorylation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0016572 ! histone phosphorylation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-09-04T16:01:06Z [Term] id: FYPO:0002592 name: abolished histone phosphorylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone phosphorylation does not occur. All histone phosphorylation may be affected, or phosphorylation of specific sites on specific histones may be abolished." [PomBase:mah] synonym: "abolished histone phosphorylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished histone phosphorylation during vegetative growth" EXACT [PomBase:mah] synonym: "histone phosphorylation abolished" EXACT [PomBase:mah] synonym: "histone phosphorylation absent" EXACT [PomBase:al] is_a: FYPO:0002033 ! abolished protein phosphorylation during vegetative growth is_a: FYPO:0002591 ! abnormal histone phosphorylation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0016572 ! histone phosphorylation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0016572 ! histone phosphorylation created_by: midori creation_date: 2013-09-04T16:01:32Z [Term] id: FYPO:0002593 name: decreased histone phosphorylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone phosphorylation occurs to a lower extent than normal. All histone phosphorylation may be affected, or phosphorylation of specific sites on specific histones may be decreased." [PomBase:mah] synonym: "decreased histone phosphorylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone phosphorylation during vegetative growth" EXACT [PomBase:mah] synonym: "reduced histone phosphorylation" EXACT [PomBase:mah] is_a: FYPO:0001838 ! decreased protein phosphorylation during vegetative growth is_a: FYPO:0002591 ! abnormal histone phosphorylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0016572 ! histone phosphorylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0016572 ! histone phosphorylation created_by: midori creation_date: 2013-09-04T16:01:46Z [Term] id: FYPO:0002594 name: increased histone phosphorylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone phosphorylation occurs to a greater extent than normal. All histone phosphorylation may be affected, or phosphorylation of specific sites on specific histones may be increased." [PomBase:mah] synonym: "increased histone phosphorylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone phosphorylation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001038 ! increased protein phosphorylation during vegetative growth is_a: FYPO:0002591 ! abnormal histone phosphorylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0016572 ! histone phosphorylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0016572 ! histone phosphorylation created_by: midori creation_date: 2013-09-04T16:01:59Z [Term] id: FYPO:0002595 name: normal histone phosphorylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone phosphorylation is normal. All histone phosphorylation may be assayed, or phosphorylation of specific sites on specific histones may be measured." [PomBase:mah] synonym: "abnormal histone phosphorylation during vegetative growth" EXACT [PomBase:mah] synonym: "normal histone phosphorylation during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000776 ! normal protein phosphorylation during vegetative growth is_a: FYPO:0002600 ! normal histone modification intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0016572 ! histone phosphorylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0016572 ! histone phosphorylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-09-04T16:02:14Z [Term] id: FYPO:0002596 name: increased histone H2A phosphorylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone H2A phosphorylation occurs to a greater extent than normal. All histone H2A phosphorylation may be affected, or phosphorylation of specific sites on histone H2A may be increased." [PomBase:mah] synonym: "increased histone H2A phosphorylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H2A phosphorylation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002594 ! increased histone phosphorylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990164 ! histone H2A phosphorylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990164 ! histone H2A phosphorylation created_by: midori creation_date: 2013-09-04T16:18:17Z [Term] id: FYPO:0002597 name: abolished histone H2A phosphorylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone H2A phosphorylation does not occur. All histone H2A phosphorylation may be affected, or phosphorylation of specific sites on histone H2A may be abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished histone H2A phosphorylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished histone H2A phosphorylation during vegetative growth" EXACT [PomBase:mah] synonym: "histone H2A phosphorylation abolished" EXACT [PomBase:mah] synonym: "histone H2A phosphorylation absent" EXACT [PomBase:al] is_a: FYPO:0002592 ! abolished histone phosphorylation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1990164 ! histone H2A phosphorylation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1990164 ! histone H2A phosphorylation created_by: midori creation_date: 2013-09-04T16:18:17Z [Term] id: FYPO:0002598 name: decreased histone H2A phosphorylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone H2A phosphorylation occurs to a lower extent than normal. All histone H2A phosphorylation may be affected, or phosphorylation of specific sites on histone H2A may be decreased." [PomBase:mah] synonym: "decreased histone H2A phosphorylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H2A phosphorylation during vegetative growth" EXACT [PomBase:mah] synonym: "reduced histone H2A phosphorylation" EXACT [PomBase:mah] is_a: FYPO:0002593 ! decreased histone phosphorylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990164 ! histone H2A phosphorylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990164 ! histone H2A phosphorylation created_by: midori creation_date: 2013-09-04T16:18:17Z [Term] id: FYPO:0002599 name: abnormal histone H2A phosphorylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone H2A phosphorylation is abnormal. All histone H2A phosphorylation may be affected, or phosphorylation of specific sites on histone H2A may be altered." [PomBase:mah] synonym: "abnormal histone H2A phosphorylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal histone H2A phosphorylation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002591 ! abnormal histone phosphorylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1990164 ! histone H2A phosphorylation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1990164 ! histone H2A phosphorylation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-09-04T16:18:17Z [Term] id: FYPO:0002600 name: normal histone modification def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone modification is normal. All histone modification may be assayed, or modification of specific sites on specific histones may be measured." [PomBase:mah] synonym: "abnormal histone phosphorylation during vegetative growth" EXACT [PomBase:mah] synonym: "normal histone modification during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000549 ! normal protein modification during vegetative growth is_a: FYPO:0002891 ! normal chromatin organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0016570 ! histone modification intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0016570 ! histone modification relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-09-04T16:18:49Z [Term] id: FYPO:0002601 name: normal histone H2A phosphorylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone H2A phosphorylation is normal. All histone H2A phosphorylation may be assayed, or phosphorylation of specific sites on histone H2A may be measured." [PomBase:mah] synonym: "normal histone H2A phosphorylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal histone H2A phosphorylation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002595 ! normal histone phosphorylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990164 ! histone H2A phosphorylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990164 ! histone H2A phosphorylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-09-04T16:19:00Z [Term] id: FYPO:0002602 name: decreased histone H2A phosphorylation during mitotic S phase def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone H2A phosphorylation occurs to a lower extent than normal during S phase of the mitotic cell cycle. All histone H2A phosphorylation may be affected, or phosphorylation of specific sites on histone H2A may be decreased." [PomBase:mah] synonym: "decreased histone H2A phosphorylation during mitotic S phase during vegetative growth" EXACT [PomBase:mah] synonym: "reduced histone H2A phosphorylation during mitotic S phase" EXACT [PomBase:mah] is_a: FYPO:0002598 ! decreased histone H2A phosphorylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0000084 ! mitotic S phase intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990164 ! histone H2A phosphorylation relationship: happens_during GO:0000084 ! mitotic S phase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990164 ! histone H2A phosphorylation created_by: midori creation_date: 2013-09-04T16:36:11Z [Term] id: FYPO:0002603 name: abolished histone H2A phosphorylation at mating type locus during mitotic S phase def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone H2A phosphorylation does not occur at the mating type locus during S phase of the mitotic cell cycle. All histone H2A phosphorylation may be affected, or phosphorylation of specific sites on histone H2A may be abolished." [PomBase:mah] synonym: "abolished histone H2A phosphorylation at mating type locus during mitotic S phase during vegetative growth" EXACT [PomBase:mah] synonym: "abolished histone H2A phosphorylation at mating type region during mitotic S phase" EXACT [PomBase:mah, SO:0001789] synonym: "histone H2A phosphorylation abolished at mating type locus during mitotic S phase" EXACT [PomBase:mah] synonym: "histone H2A phosphorylation absent at mating type locus during mitotic S phase" EXACT [PomBase:al] is_a: FYPO:0002597 ! abolished histone H2A phosphorylation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0000084 ! mitotic S phase intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: occurs_at SO:0001789 ! mating_type_region intersection_of: towards GO:1990164 ! histone H2A phosphorylation relationship: during GO:0000084 ! mitotic S phase relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: occurs_at SO:0001789 ! mating_type_region relationship: towards GO:1990164 ! histone H2A phosphorylation created_by: midori creation_date: 2013-09-04T16:37:06Z [Term] id: FYPO:0002604 name: increased histone H2A phosphorylation at rDNA def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone H2A phosphorylation occurs to a greater extent than normal at ribosomal DNA. All histone H2A phosphorylation may be affected, or phosphorylation of specific sites on histone H2A may be increased." [PomBase:mah] synonym: "increased histone H2A phosphorylation at rDNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H2A phosphorylation at ribosomal DNA during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002596 ! increased histone H2A phosphorylation created_by: midori creation_date: 2013-09-04T16:38:42Z [Term] id: FYPO:0002605 name: increased histone H2A phosphorylation at rDNA during mitotic G2 phase def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone H2A phosphorylation occurs to a greater extent than normal at ribosomal DNA during G2 phase of the mitotic cell cycle. All histone H2A phosphorylation may be affected, or phosphorylation of specific sites on histone H2A may be increased." [PomBase:mah] synonym: "increased histone H2A phosphorylation at rDNA during mitotic G2 phase during vegetative growth" EXACT [PomBase:mah] synonym: "increased histone H2A phosphorylation at ribosomal DNA during mitotic G2 phase" EXACT [PomBase:mah] is_a: FYPO:0002604 ! increased histone H2A phosphorylation at rDNA created_by: midori creation_date: 2013-09-04T16:57:55Z [Term] id: FYPO:0002606 name: increased histone H2A phosphorylation at rDNA during mitotic S phase def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone H2A phosphorylation occurs to a greater extent than normal at ribosomal DNA during S phase of the mitotic cell cycle. All histone H2A phosphorylation may be affected, or phosphorylation of specific sites on histone H2A may be increased." [PomBase:mah] synonym: "increased histone H2A phosphorylation at rDNA during mitotic S phase during vegetative growth" EXACT [PomBase:mah] synonym: "increased histone H2A phosphorylation at ribosomal DNA during mitotic S phase" EXACT [PomBase:mah] is_a: FYPO:0002604 ! increased histone H2A phosphorylation at rDNA created_by: midori creation_date: 2013-09-04T17:02:48Z [Term] id: FYPO:0002607 name: increased histone H2A phosphorylation at centromeric tDNA during mitotic S phase def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone H2A phosphorylation occurs to a greater extent than normal at tRNA genes (tDNA) in centromeric regions during S phase of the mitotic cell cycle. All histone H2A phosphorylation may be affected, or phosphorylation of specific sites on histone H2A may be increased." [PomBase:mah] synonym: "increased histone H2A phosphorylation at centromeric tDNA during mitotic S phase during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002596 ! increased histone H2A phosphorylation created_by: midori creation_date: 2013-09-04T17:03:08Z [Term] id: FYPO:0002608 name: increased histone H2A phosphorylation during cellular response to hydroxyurea def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone H2A phosphorylation occurs to a greater extent than normal. All histone H2A phosphorylation may be affected, or phosphorylation of specific sites on histone H2A may be increased." [PomBase:mah] synonym: "increased histone H2A phosphorylation during cellular response to HU" EXACT [PomBase:mah] synonym: "increased histone H2A phosphorylation during cellular response to hydroxyurea during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H2A phosphorylation during cellular response to hydroxyurea during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002096 ! increased protein phosphorylation during cellular response to hydroxyurea is_a: FYPO:0002596 ! increased histone H2A phosphorylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: happens_during GO:0072711 ! cellular response to hydroxyurea intersection_of: inheres_in GO:1990164 ! histone H2A phosphorylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: happens_during GO:0072711 ! cellular response to hydroxyurea relationship: inheres_in GO:1990164 ! histone H2A phosphorylation created_by: midori creation_date: 2013-09-04T17:03:47Z [Term] id: FYPO:0002609 name: decreased histone H2A phosphorylation at centromere outer repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone H2A phosphorylation occurs to a lower extent than normal at centromeric outer repeat regions. All histone H2A phosphorylation may be affected, or phosphorylation of specific sites on histone H2A may be decreased." [PomBase:mah] synonym: "decreased histone H2A phosphorylation at centromere otr" EXACT [PomBase:mah] synonym: "decreased histone H2A phosphorylation at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H2A phosphorylation at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] synonym: "decreased histone H2A phosphorylation at centromeric outer repeat region" EXACT [PomBase:mah] synonym: "decreased histone H2A phosphorylation at pericentric region" RELATED [PomBase:mah] synonym: "decreased histone H2A phosphorylation at pericentromeric region" RELATED [PomBase:mah] synonym: "reduced histone H2A phosphorylation at centromere outer repeat" EXACT [PomBase:mah] is_a: FYPO:0002598 ! decreased histone H2A phosphorylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990164 ! histone H2A phosphorylation intersection_of: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990164 ! histone H2A phosphorylation relationship: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region created_by: midori creation_date: 2013-09-04T17:04:16Z [Term] id: FYPO:0002610 name: normal histone H2A phosphorylation at centromere outer repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone H2A phosphorylation is normal at centromeric outer repeat regions. All histone H2A phosphorylation may be assayed, or phosphorylation of specific sites on histone H2A may be measured." [PomBase:mah] synonym: "abnormal histone H2A phosphorylation at centromere otr" EXACT [PomBase:mah] synonym: "abnormal histone H2A phosphorylation at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal histone H2A phosphorylation at centromeric outer repeat region" EXACT [PomBase:mah] synonym: "abnormal histone H2A phosphorylation at pericentric region" RELATED [PomBase:mah] synonym: "abnormal histone H2A phosphorylation at pericentromeric region" RELATED [PomBase:mah] synonym: "normal histone H2A phosphorylation at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0002601 ! normal histone H2A phosphorylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990164 ! histone H2A phosphorylation intersection_of: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990164 ! histone H2A phosphorylation relationship: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-09-04T17:04:50Z [Term] id: FYPO:0002611 name: decreased histone H2A phosphorylation at subtelomere during mitotic S phase def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone H2A phosphorylation occurs to a lower extent than normal at subtelomeric regions during S phase of the mitotic cell cycle. All histone H2A phosphorylation may be affected, or phosphorylation of specific sites on histone H2A may be decreased." [PomBase:mah] synonym: "decreased histone H2A phosphorylation at subtelomere during mitotic S phase during vegetative growth" EXACT [PomBase:mah] synonym: "reduced decreased histone H2A phosphorylation at subtelomere during mitotic S phase" EXACT [PomBase:mah] is_a: FYPO:0002598 ! decreased histone H2A phosphorylation created_by: midori creation_date: 2013-09-04T17:12:50Z [Term] id: FYPO:0002612 name: normal histone H2A phosphorylation at subtelomere def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone H2A phosphorylation is normal at subtelomeric regions. All histone H2A phosphorylation may be assayed, or phosphorylation of specific sites on histone H2A may be measured." [PomBase:mah] synonym: "normal histone H2A phosphorylation at subtelomere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal histone H2A phosphorylation at subtelomere during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002601 ! normal histone H2A phosphorylation created_by: midori creation_date: 2013-09-04T17:13:15Z [Term] id: FYPO:0002613 name: normal histone H2A phosphorylation at mating type locus def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone H2A phosphorylation is normal at the mating type locus. All histone H2A phosphorylation may be assayed, or phosphorylation of specific sites on histone H2A may be measured." [PomBase:mah] synonym: "normal histone H2A phosphorylation at mating type locus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal histone H2A phosphorylation at mating type locus during vegetative growth" EXACT [PomBase:mah] synonym: "normal histone H2A phosphorylation at mating type region" EXACT [PomBase:mah, SO:0001789] is_a: FYPO:0002601 ! normal histone H2A phosphorylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990164 ! histone H2A phosphorylation intersection_of: occurs_at SO:0001789 ! mating_type_region intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990164 ! histone H2A phosphorylation relationship: occurs_at SO:0001789 ! mating_type_region relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-09-04T17:13:15Z [Term] id: FYPO:0002614 name: abnormal protein localization to pre-autophagosomal structure def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the pre-autophagosomal structure is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found at the pre-autophagosomal structure and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to PAS" EXACT [GO:0034497, PomBase:mah] synonym: "abnormal protein localisation to pre-autophagosomal structure" EXACT [PomBase:mah] synonym: "abnormal protein localization to pre-autophagosomal structure during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein localization to pre-autophagosomal structure during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000443 ! abnormal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0034497 ! protein localization to pre-autophagosomal structure intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0034497 ! protein localization to pre-autophagosomal structure relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-09-05T14:45:24Z [Term] id: FYPO:0002615 name: decreased protein localization to pre-autophagosomal structure def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the pre-autophagosomal structure is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to pre-autophagosomal structure" EXACT [PomBase:mah] synonym: "decreased protein localization to PAS" EXACT [GO:0034497, PomBase:mah] synonym: "decreased protein localization to pre-autophagosomal structure during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to pre-autophagosomal structure during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to pre-autophagosomal structure" EXACT [PomBase:mah] is_a: FYPO:0002614 ! abnormal protein localization to pre-autophagosomal structure is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034497 ! protein localization to pre-autophagosomal structure relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034497 ! protein localization to pre-autophagosomal structure created_by: midori creation_date: 2013-09-05T14:45:34Z [Term] id: FYPO:0002616 name: increased protein localization to pre-autophagosomal structure def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the pre-autophagosomal structure is increased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to pre-autophagosomal structure" EXACT [PomBase:mah] synonym: "increased protein localization to PAS" EXACT [GO:0034497, PomBase:mah] synonym: "increased protein localization to pre-autophagosomal structure during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein localization to pre-autophagosomal structure during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002614 ! abnormal protein localization to pre-autophagosomal structure is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034497 ! protein localization to pre-autophagosomal structure relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034497 ! protein localization to pre-autophagosomal structure created_by: midori creation_date: 2013-09-05T14:45:51Z [Term] id: FYPO:0002617 name: sensitive to sodium butyrate def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to sodium butyrate. Cells stop growing (and may die) at a concentration of sodium butyrate that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to sodium butyrate" EXACT [PomBase:mah] synonym: "sensitive to sodium butyrate during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to sodium butyrate during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:64103 ! sodium butyrate relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:64103 ! sodium butyrate created_by: midori creation_date: 2013-09-05T15:14:13Z [Term] id: FYPO:0002618 name: normal growth on valproic acid def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing valproic acid." [PomBase:mah] synonym: "normal cell population growth in presence of valproic acid" EXACT [PomBase:mah] synonym: "normal cell population growth on valproic acid" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to valproic acid" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on valproic acid" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:39867 ! valproic acid relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:39867 ! valproic acid created_by: midori creation_date: 2013-09-05T15:31:40Z [Term] id: FYPO:0002619 name: normal growth on sodium butyrate def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing sodium butyrate." [PomBase:mah] synonym: "normal cell population growth in presence of sodium butyrate" EXACT [PomBase:mah] synonym: "normal cell population growth on sodium butyrate" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to sodium butyrate" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on sodium butyrate" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:64103 ! sodium butyrate relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:64103 ! sodium butyrate created_by: midori creation_date: 2013-09-05T15:33:22Z [Term] id: FYPO:0002620 name: normal growth on trichostatin A def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing trichostatin A." [PomBase:mah] synonym: "normal cell population growth in presence of trichostatin A" EXACT [PomBase:mah] synonym: "normal cell population growth on trichostatin A" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to trichostatin A" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on trichostatin A" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:46024 ! trichostatin A relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:46024 ! trichostatin A created_by: midori creation_date: 2013-09-05T15:34:29Z [Term] id: FYPO:0002621 name: abnormal malate dehydrogenase (decarboxylating) (NAD+) activity def: "A molecular function phenotype in which the observed rate of malate dehydrogenase (decarboxylating) (NAD+) activity is abnormal." [PomBase:mah] synonym: "abnormal 'malic' enzyme activity" RELATED [GO:0004471] synonym: "abnormal (S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating) activity" EXACT [GO:0004471] synonym: "abnormal malate dehydrogenase (oxaloacetate-decarboxylating) activity" EXACT [GO:0004471] synonym: "abnormal NAD-linked malic enzyme activity" RELATED [GO:0004471] synonym: "abnormal NAD-malic enzyme activity" BROAD [GO:0004471] synonym: "abnormal NAD-specific malic enzyme activity" RELATED [GO:0004471] is_a: FYPO:0000689 ! abnormal oxidoreductase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004471 ! malate dehydrogenase (decarboxylating) (NAD+) activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004471 ! malate dehydrogenase (decarboxylating) (NAD+) activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-09-05T15:47:08Z [Term] id: FYPO:0002622 name: decreased malate dehydrogenase (decarboxylating) (NAD+) activity def: "A molecular function phenotype in which the observed rate of malate dehydrogenase (decarboxylating) (NAD+) activity is decreased." [PomBase:mah] synonym: "decreased 'malic' enzyme activity" RELATED [GO:0004471] synonym: "decreased (S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating) activity" EXACT [GO:0004471] synonym: "decreased malate dehydrogenase (oxaloacetate-decarboxylating) activity" EXACT [GO:0004471] synonym: "decreased NAD-linked malic enzyme activity" RELATED [GO:0004471] synonym: "decreased NAD-malic enzyme activity" BROAD [GO:0004471] synonym: "decreased NAD-specific malic enzyme activity" RELATED [GO:0004471] synonym: "reduced malate dehydrogenase (decarboxylating) (NAD+) activity" EXACT [PomBase:mah] is_a: FYPO:0000690 ! decreased oxidoreductase activity is_a: FYPO:0002621 ! abnormal malate dehydrogenase (decarboxylating) (NAD+) activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004471 ! malate dehydrogenase (decarboxylating) (NAD+) activity relationship: inheres_in GO:0004471 ! malate dehydrogenase (decarboxylating) (NAD+) activity created_by: midori creation_date: 2013-09-05T15:47:25Z [Term] id: FYPO:0002623 name: decreased RNA level during cellular response to glucose stimulus def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to a glucose stimulus is lower than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased mRNA level during cellular response to glucose stimulus" NARROW [PomBase:mah] synonym: "decreased RNA accumulation during cellular response to glucose stimulus" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to glucose" EXACT [PomBase:mah] synonym: "decreased RNA level during cellular response to glucose stimulus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to glucose stimulus during vegetative growth" EXACT [PomBase:mah] synonym: "decreased transcript level during cellular response to glucose stimulus" EXACT [PomBase:vw] synonym: "reduced RNA level during cellular response to glucose stimulus" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0071333 ! cellular response to glucose stimulus intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0071333 ! cellular response to glucose stimulus relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2013-09-05T15:50:26Z [Term] id: FYPO:0002624 name: decreased punctate nuclear protein localization def: "A cell phenotype in which a protein that is normally localized to discrete regions in the nucleus, visible as foci or dots by fluorescence microscopy, is abnormally localized such that fewer dots are observed than in normal (wild type) cells." [PomBase:mah] synonym: "decreased punctate nuclear protein localisation" EXACT [PomBase:mah] synonym: "decreased punctate nuclear protein localization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased punctate nuclear protein localization during vegetative growth" EXACT [PomBase:mah] synonym: "reduced punctate nuclear protein localization" EXACT [PomBase:mah] is_a: FYPO:0000782 ! mislocalized protein during vegetative growth created_by: midori creation_date: 2013-09-05T16:01:22Z [Term] id: FYPO:0002625 name: normal protein localization to rDNA def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to parts of the chromosome containing ribosomal DNA is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to rDNA" EXACT [PomBase:mah] synonym: "normal protein localization to rDNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to rDNA during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein localization to ribosomal DNA" EXACT [PomBase:mah] is_a: FYPO:0000644 ! normal protein localization during vegetative growth created_by: midori creation_date: 2013-09-05T16:03:48Z [Term] id: FYPO:0002626 name: resistance to heat def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which cells show decreased sensitivity to heat." [PomBase:mah] comment: For fission yeast, high temperature usually corresponds to above 32 degrees Celsius. Use this term if you have assayed growth of cells exposed to heat in culture. If you have assayed the response to heat at the subcellular or molecular level, consider annotating to 'abnormal cellular response to heat' (FYPO:0000212). synonym: "heat resistance" EXACT [PomBase:mah] synonym: "resistance to heat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to heat during vegetative growth" EXACT [PomBase:mah] synonym: "resistance to high temperature" EXACT [PomBase:al] synonym: "resistant to heat" EXACT [PomBase:mah] is_a: FYPO:0000850 ! resistance to stress during vegetative growth created_by: midori creation_date: 2013-09-05T16:10:37Z [Term] id: FYPO:0002627 name: altered level of substance in cell wall def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of a specific substance measured in the cell wall differs from normal." [PomBase:mah] synonym: "abnormal level of substance in cell wall" EXACT [PomBase:mah] synonym: "abnormal level of substance in cell wall during vegetative growth" EXACT [PomBase:mah] synonym: "altered level of substance in cell wall during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: FYPO:0001323 ! altered level of substance in cell during vegetative growth is_a: FYPO:0002946 ! abnormal cell wall intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0009277 ! fungal-type cell wall intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:24431 ! chemical entity relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0009277 ! fungal-type cell wall relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:24431 ! chemical entity created_by: midori creation_date: 2013-09-05T16:37:47Z [Term] id: FYPO:0002628 name: decreased level of substance in cell wall def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of a specific substance measured in the cell wall is lower than normal." [PomBase:mah] synonym: "decreased level of substance in cell wall during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased level of substance in cell wall during vegetative growth" EXACT [PomBase:mah] synonym: "reduced level of substance in cell wall" EXACT [PomBase:mah] is_a: FYPO:0001329 ! decreased level of substance in cell during vegetative growth is_a: FYPO:0002627 ! altered level of substance in cell wall intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0009277 ! fungal-type cell wall intersection_of: towards CHEBI:24431 ! chemical entity relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0009277 ! fungal-type cell wall relationship: towards CHEBI:24431 ! chemical entity created_by: midori creation_date: 2013-09-05T16:41:13Z [Term] id: FYPO:0002629 name: galactose absent from cell wall def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of galactose measured in the cell wall is too low to detect." [PomBase:mah] comment: Note that 'galactose absent from cell wall glycoprotein glycan' (FYPO:0003727) is not a child of this term because the cell wall may contain galactose residues in glycans that are not part of glycosylated proteins. synonym: "galactose absent from cell surface" RELATED [PomBase:al] synonym: "galactose absent from cell wall during mitotic cell cycle" RELATED [PomBase:mah] synonym: "galactose absent from cell wall during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001208 ! substance absent from cell during vegetative growth is_a: FYPO:0002628 ! decreased level of substance in cell wall intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0009277 ! fungal-type cell wall intersection_of: towards CHEBI:12936 ! D-galactose relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0009277 ! fungal-type cell wall relationship: towards CHEBI:12936 ! D-galactose created_by: midori creation_date: 2013-09-05T16:54:57Z [Term] id: FYPO:0002630 name: irregular cell wall during vegetative growth def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the outer surface of the fungal-type cell wall is rougher and less regular than normal." [PomBase:al, PomBase:mah] synonym: "irregular cell wall during mitotic cell cycle" RELATED [PomBase:mah] synonym: "irregular cell wall surface texture during vegetative growth" EXACT [PATO:0000700, PomBase:mah] synonym: "rough cell wall during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000351 ! abnormal cell wall morphology during vegetative growth is_a: PATO:0000700 ! rough intersection_of: PATO:0000700 ! rough intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0009277 ! fungal-type cell wall relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0009277 ! fungal-type cell wall created_by: midori creation_date: 2013-09-05T17:07:11Z [Term] id: FYPO:0002631 name: abnormal dTTP biosynthetic process def: "A metabolism phenotype observed in the vegetative growth phase of the life cycle in which dTTP biosynthesis is abnormal." [PomBase:mah] synonym: "abnormal dTTP biosynthesis" EXACT [GO:0006235, PomBase:mah] synonym: "abnormal dTTP biosynthetic process during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal dTTP biosynthetic process during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001363 ! abnormal metabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006235 ! dTTP biosynthetic process intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006235 ! dTTP biosynthetic process relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-09-05T17:18:46Z [Term] id: FYPO:0002632 name: decreased dTTP biosynthetic process def: "A metabolism phenotype observed in the vegetative growth phase of the life cycle in which dTTP biosynthesis is decreased." [PomBase:mah] synonym: "abnormal dTTP biosynthesis" EXACT [GO:0006235, PomBase:mah] synonym: "abnormal dTTP biosynthetic process during vegetative growth" EXACT [PomBase:mah] synonym: "decreased dTTP biosynthetic process during mitotic cell cycle" RELATED [PomBase:mah] synonym: "reduced dTTP biosynthetic process" EXACT [PomBase:mah] is_a: FYPO:0002631 ! abnormal dTTP biosynthetic process is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006235 ! dTTP biosynthetic process relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006235 ! dTTP biosynthetic process created_by: midori creation_date: 2013-09-05T17:18:50Z [Term] id: FYPO:0002633 name: increased cellular dTTP level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of dTTP measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular dTTP level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular dTTP level during vegetative growth" EXACT [PomBase:mah] synonym: "increased dTTP accumulation" RELATED [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:18077 ! dTTP relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:18077 ! dTTP created_by: midori creation_date: 2013-09-05T17:21:44Z [Term] id: FYPO:0002634 name: resistance to cobalt def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of cobalt ions than normal." [PomBase:mah] synonym: "resistance to cobalt during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to cobalt during vegetative growth" EXACT [PomBase:mah] synonym: "resistance to cobalt ion" EXACT [PomBase:mah] synonym: "resistant to cobalt" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:48828 ! cobalt(2+) relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:48828 ! cobalt(2+) created_by: midori creation_date: 2013-09-06T16:22:20Z [Term] id: FYPO:0002635 name: normal protein ubiquitination def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the ubiquitination of one or more specific proteins, or of specific protein sites, is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal protein ubiquitination during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein ubiquitination during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein/peptide ubiquitination" EXACT [PomBase:mah] is_a: FYPO:0000549 ! normal protein modification during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0016567 ! protein ubiquitination intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0016567 ! protein ubiquitination relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-09-11T13:01:58Z [Term] id: FYPO:0002636 name: delayed mitotic spindle elongation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitotic spindle elongation begins later than normal." [PomBase:mah] synonym: "delayed mitotic spindle elongation during vegetative growth" EXACT [PomBase:mah] synonym: "mitotic spindle elongation delayed" EXACT [PomBase:vw] is_a: FYPO:0000131 ! abnormal mitotic spindle elongation is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000022 ! mitotic spindle elongation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000022 ! mitotic spindle elongation created_by: midori creation_date: 2013-09-11T13:43:06Z [Term] id: FYPO:0002637 name: normal growth on hygromycin B def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing hygromycin B." [PomBase:mah] synonym: "normal cell population growth in presence of hygromycin B" EXACT [PomBase:mah] synonym: "normal cell population growth on hygromycin B" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal vegetative cell population growth on hygromycin B" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:16976 ! hygromycin B relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:16976 ! hygromycin B created_by: midori creation_date: 2013-09-11T14:14:32Z [Term] id: FYPO:0002638 name: increased activation of mitotic cell cycle spindle assembly checkpoint def: "A cell cycle checkpoint phenotype in which the spindle assembly checkpoint is activated more frequently than normal, typically under conditions that do not cause checkpoint activation in wild-type cells. The mitotic spindle assembly checkpoint normally delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [PomBase:mah, PomBase:vw] comment: Checkpoint activation in a mutant usually implies that the mutation is causing problems that the checkpoint detects. synonym: "increased mitotic cell cycle spindle assembly checkpoint activation" EXACT [PomBase:mah] is_a: FYPO:0000168 ! abnormal mitotic cell cycle spindle assembly checkpoint is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0090268 ! activation of mitotic cell cycle spindle assembly checkpoint relationship: inheres_in GO:0090268 ! activation of mitotic cell cycle spindle assembly checkpoint created_by: midori creation_date: 2013-09-11T14:32:46Z [Term] id: FYPO:0002639 name: increased interkinetochore distance before mitotic anaphase def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the distance between sister kinetochores is greater than normal before the onset of mitotic anaphase." [PMID:22065639, PomBase:mah] comment: Also see 'abnormal kinetochore localization' (FYPO:0001778) and 'abnormal mitotic sister chromatid segregation' (FYPO:0000141). synonym: "increased distance between mitotic kinetochores" RELATED [PomBase:vw] synonym: "increased interkinetochore distance before anaphase onset" EXACT [PMID:22065639] synonym: "increased sister kinetochore distance before mitotic anaphase" EXACT [PMID:22065639, PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth relationship: output_of FYPO:0001778 ! abnormal centromere localization created_by: midori creation_date: 2013-09-11T15:30:13Z [Term] id: FYPO:0002640 name: sensitive to clotrimazole def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to clotrimazole. Cells stop growing (and may die) at a concentration of clotrimazole that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to clotrimazole" EXACT [PomBase:mah] synonym: "sensitive to clotrimazole during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to clotrimazole during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:3764 ! clotrimazole relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:3764 ! clotrimazole created_by: midori creation_date: 2013-09-12T11:46:38Z [Term] id: FYPO:0002641 name: sensitive to micafungin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to micafungin. Cells stop growing (and may die) at a concentration of micafungin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to micafungin" EXACT [PomBase:mah] synonym: "sensitive to micafungin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to micafungin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:600520 ! micafungin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:600520 ! micafungin created_by: midori creation_date: 2013-09-12T11:47:24Z [Term] id: FYPO:0002642 name: sensitive to amphotericin B def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to amphotericin B. Cells stop growing (and may die) at a concentration of amphotericin B that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to amphotericin B" EXACT [PomBase:mah] synonym: "sensitive to amphotericin B during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to amphotericin B during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:2682 ! amphotericin B relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:2682 ! amphotericin B created_by: midori creation_date: 2013-09-12T11:48:40Z [Term] id: FYPO:0002643 name: normal growth on clotrimazole def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing clotrimazole." [PomBase:mah] synonym: "normal cell population growth in presence of clotrimazole" EXACT [PomBase:mah] synonym: "normal cell population growth on clotrimazole" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to clotrimazole" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on clotrimazole" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:3764 ! clotrimazole relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:3764 ! clotrimazole created_by: midori creation_date: 2013-09-12T11:50:34Z [Term] id: FYPO:0002644 name: decreased protein serine phosphorylation during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of serine residues in one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased peptidyl-serine phosphorylation during vegetative growth" EXACT [GO:0018105, PomBase:mah] synonym: "decreased protein serine phosphorylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased serine phosphorylation during vegetative growth" EXACT [PomBase:al] synonym: "reduced protein serine phosphorylation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001838 ! decreased protein phosphorylation during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0018105 ! peptidyl-serine phosphorylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0018105 ! peptidyl-serine phosphorylation created_by: midori creation_date: 2013-09-12T12:43:00Z [Term] id: FYPO:0002645 name: decreased protein threonine phosphorylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of threonine residues in one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased peptidyl-threonine phosphorylation" EXACT [GO:0018107, PomBase:mah] synonym: "decreased protein threonine phosphorylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein threonine phosphorylation during vegetative growth" EXACT [PomBase:mah] synonym: "decreased threonine phosphorylation" EXACT [PomBase:al] synonym: "reduced protein threonine phosphorylation" EXACT [PomBase:mah] is_a: FYPO:0001838 ! decreased protein phosphorylation during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0018107 ! peptidyl-threonine phosphorylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0018107 ! peptidyl-threonine phosphorylation created_by: midori creation_date: 2013-09-12T12:47:56Z [Term] id: FYPO:0002646 name: decreased protein serine phosphorylation during mitotic M phase def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of serine residues in one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal during M phase of the mitotic cell cycle." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased peptidyl-serine phosphorylation during cellular response to osmotic stress" EXACT [GO:0018105, PomBase:mah] synonym: "decreased protein serine phosphorylation during cellular response to osmotic stress during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein serine phosphorylation during mitotic M phase during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased serine phosphorylation during cellular response to osmotic stress" EXACT [PomBase:al] synonym: "reduced protein serine phosphorylation during cellular response to osmotic stress" EXACT [PomBase:mah] is_a: FYPO:0002644 ! decreased protein serine phosphorylation during vegetative growth is_a: FYPO:0002832 ! decreased protein phosphorylation during mitotic M phase intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0000087 ! mitotic M phase intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0018105 ! peptidyl-serine phosphorylation relationship: happens_during GO:0000087 ! mitotic M phase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0018105 ! peptidyl-serine phosphorylation created_by: midori creation_date: 2013-09-12T12:52:24Z [Term] id: FYPO:0002647 name: decreased protein threonine phosphorylation during mitotic M phase def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of threonine residues in one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal during M phase of the mitotic cell cycle." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased peptidyl-threonine phosphorylation during cellular response to osmotic stress" EXACT [GO:0018107, PomBase:mah] synonym: "decreased protein threonine phosphorylation during cellular response to osmotic stress during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein threonine phosphorylation during mitotic M phase during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased threonine phosphorylation during cellular response to osmotic stress" EXACT [PomBase:al] synonym: "reduced protein threonine phosphorylation during cellular response to osmotic stress" EXACT [PomBase:mah] is_a: FYPO:0002645 ! decreased protein threonine phosphorylation is_a: FYPO:0002832 ! decreased protein phosphorylation during mitotic M phase intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0000087 ! mitotic M phase intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0018107 ! peptidyl-threonine phosphorylation relationship: happens_during GO:0000087 ! mitotic M phase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0018107 ! peptidyl-threonine phosphorylation created_by: midori creation_date: 2013-09-12T13:03:07Z [Term] id: FYPO:0002648 name: increased protein phosphorylation during mitotic prometaphase def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a greater extent than normal during prometaphase of the mitotic cell cycle." [PomBase:mah] synonym: "increased protein phosphorylation during mitotic prometaphase during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001038 ! increased protein phosphorylation during vegetative growth intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0000236 ! mitotic prometaphase intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0000236 ! mitotic prometaphase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2013-09-12T13:04:18Z [Term] id: FYPO:0002649 name: elongated kinetochore def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the kinetochore is longer than normal." [PomBase:mah] synonym: "elongated kinetochore during mitotic cell cycle" RELATED [PomBase:mah] synonym: "elongated kinetochore during vegetative growth" EXACT [PomBase:mah] synonym: "elongated kinetochores" EXACT [PomBase:vw] is_a: FYPO:0000050 ! abnormal kinetochore morphology is_a: PATO:0000573 ! increased length intersection_of: PATO:0000573 ! increased length intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000776 ! kinetochore relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000776 ! kinetochore created_by: midori creation_date: 2013-09-12T13:42:23Z [Term] id: FYPO:0002650 name: split kinetochore def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the kinetochore is divided into two or more parts." [PomBase:mah] synonym: "split kinetochore during mitotic cell cycle" RELATED [PomBase:mah] synonym: "split kinetochore during vegetative growth" EXACT [PomBase:mah] synonym: "split kinetochores" EXACT [PomBase:vw] is_a: FYPO:0000050 ! abnormal kinetochore morphology is_a: PATO:0001786 ! split intersection_of: PATO:0001786 ! split intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000776 ! kinetochore relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000776 ! kinetochore created_by: midori creation_date: 2013-09-12T13:45:31Z [Term] id: FYPO:0002651 name: merotelic kinetochore attachment def: "A cellular process phenotype in which the attachment of spindle microtubules to the kinetochore during a mitotic or meiotic nuclear division results in the connection of a single kinetochore to both spindle poles." [PMID:17426725, PMID:21306900] comment: Also consider 'lagging chromosomes' (FYPO:0002090), because merotelic attachment often causes chromosomes to lag during segregation. synonym: "merotelic attachment of spindle microtubules to kinetochore" EXACT [PomBase:mah] is_a: FYPO:0000325 ! abnormal attachment of spindle microtubules to kinetochore created_by: midori creation_date: 2013-09-12T14:10:20Z [Term] id: FYPO:0002652 name: excess intracellular endomembrane system present def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells contain more intracellular endomembrane system structures than normal. The endomembrane system includes the endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope; in this phenotype, excess plasma membrane does not accumulate, but increased amounts of one or more internal intracellular endomembrane system structures may be present." [PMID:21899677, PomBase:mah, PomBase:vw] synonym: "accumulation of internal endomembrane system structures" EXACT [PomBase:vw] synonym: "excess intracellular endomembrane system present during mitotic cell cycle" RELATED [PomBase:mah] synonym: "excess intracellular endomembrane system present during vegetative growth" EXACT [PomBase:mah] synonym: "increased level of intracellular endomembrane system structures" RELATED [PomBase:mah] synonym: "intracellular endomembrane system structures present in greater numbers" EXACT [PomBase:mah] is_a: FYPO:0002404 ! abnormal endomembrane system created_by: midori creation_date: 2013-09-12T15:12:13Z [Term] id: FYPO:0002653 name: decreased vacuolar import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of vacuolar import, i.e. the transport of substances into the vacuole, is decreased." [PomBase:mah] synonym: "decreased vacuolar import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased vacuolar import during vegetative growth" EXACT [PomBase:mah] synonym: "reduced vacuolar import" EXACT [PomBase:mah] synonym: "vacuolar transport: decreased" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000598 ! decreased vacuolar transport created_by: midori creation_date: 2013-09-12T15:27:05Z [Term] id: FYPO:0002654 name: enlarged exocytic vesicles def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which exocytic vesicles are larger than normal." [PomBase:mah] synonym: "enlarged exocytic vesicles during mitotic cell cycle" RELATED [PomBase:mah] synonym: "enlarged exocytic vesicles during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: PATO:0000586 ! increased size intersection_of: PATO:0000586 ! increased size intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0070382 ! exocytic vesicle relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0070382 ! exocytic vesicle created_by: midori creation_date: 2013-09-12T15:31:06Z [Term] id: FYPO:0002655 name: enlarged exocytic vesicles present in greater numbers def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells contain more exocytic vesicles than normal, and the vesicles are larger than normal." [PomBase:mah] synonym: "accumulation of enlarged exocytic vesicles" RELATED [PomBase:vw] synonym: "additional enlarged exocytic vesicles present" EXACT [PomBase:mah] synonym: "enlarged exocytic vesicles present in greater numbers during mitotic cell cycle" RELATED [PomBase:mah] synonym: "enlarged exocytic vesicles present in greater numbers during vegetative growth" EXACT [PomBase:mah] synonym: "enlarged exocytotic vesicles present in greater numbers" EXACT [GO:0070382] synonym: "enlarged post-Golgi secretory vesicles present in greater numbers" RELATED [PomBase:vw] synonym: "extra enlarged exocytic vesicles" EXACT [PomBase:mah] is_a: FYPO:0004639 ! abnormal cellular physical quality phenotype during vegetative growth intersection_of: FYPO:0004638 ! abnormal cellular physical quality phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0002086 ! exocytic vesicles present in greater numbers intersection_of: has_part FYPO:0002654 ! enlarged exocytic vesicles relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0002086 ! exocytic vesicles present in greater numbers relationship: has_part FYPO:0002654 ! enlarged exocytic vesicles created_by: midori creation_date: 2013-09-12T15:32:02Z [Term] id: FYPO:0002656 name: decreased actin filament binding def: "A molecular function phenotype in which the binding of a protein to one or more actin filaments occurs to a lower extent than normal. The affected protein may be encoded by the mutated gene, or by a different gene." [PomBase:mah] comment: This term can be used for any interaction with actin filaments that is affected by a mutation, whether or not the mutated gene product is one of the interacting proteins. We recommend noting which proteins were used in the assay when annotating to this term. synonym: "decreased F-actin binding" EXACT [PomBase:mah] synonym: "decreased filamentous actin binding" RELATED [PomBase:mah] synonym: "reduced actin filament binding" EXACT [PomBase:mah] is_a: FYPO:0001645 ! decreased protein binding is_a: FYPO:0003591 ! abnormal protein complex binding intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0051015 ! actin filament binding relationship: inheres_in GO:0051015 ! actin filament binding created_by: midori creation_date: 2013-09-12T16:18:53Z [Term] id: FYPO:0002657 name: normal occurrence of activation of bipolar cell growth def: "A regulation phenotype observed in the vegetative growth phase of the life cycle in which activation of bipolar cell growth occurs to the same extent as in wild-type cells." [PomBase:mah] synonym: "normal frequency of activation of bipolar cell growth" RELATED [PomBase:mah] synonym: "normal NETO frequency" RELATED [PomBase:mah] synonym: "normal NETO occurrence" EXACT [PomBase:mah] synonym: "normal occurrence of activation of bipolar vegetative cell growth" EXACT [PomBase:mah] synonym: "normal occurrence of new end take off" EXACT [PomBase:mah] is_a: FYPO:0001396 ! normal activation of bipolar cell growth is_a: PATO:0000057 ! occurrence intersection_of: PATO:0000057 ! occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051519 ! activation of bipolar cell growth intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051519 ! activation of bipolar cell growth relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-09-12T16:37:35Z [Term] id: FYPO:0002658 name: increased cellular trehalose 6-phosphate level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of trehalose 6-phosphate measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular trehalose 6-phosphate level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular trehalose 6-phosphate level during vegetative growth" EXACT [PomBase:mah] synonym: "increased cellular trehalose-6P level" EXACT [PomBase:al] synonym: "increased trehalose 6-phosphate accumulation" RELATED [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:18283 ! alpha,alpha-trehalose 6-phosphate relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:18283 ! alpha,alpha-trehalose 6-phosphate created_by: midori creation_date: 2013-09-18T11:47:38Z [Term] id: FYPO:0002659 name: increased cellular trehalose 6-phosphate level during heat shock def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of trehalose 6-phosphate measured in a cell is higher than normal when the cell is subject to heat shock." [PomBase:mah] synonym: "increased cellular trehalose 6-phosphate level during heat shock during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular trehalose 6-phosphate level during vegetative growth and during heat shock" EXACT [PomBase:mah] synonym: "increased cellular trehalose-6P level during heat shock" EXACT [PomBase:al] synonym: "increased trehalose 6-phosphate accumulation during heat shock" RELATED [PomBase:mah] is_a: FYPO:0002658 ! increased cellular trehalose 6-phosphate level created_by: midori creation_date: 2013-09-18T11:47:57Z [Term] id: FYPO:0002660 name: decreased cellular trehalose 6-phosphate level def: "A cell phenotype in which the amount of trehalose 6-phosphate measured in a cell is lower than normal." [PomBase:mah] synonym: "decreased cellular trehalose 6-phosphate accumulation" RELATED [PomBase:mah] synonym: "decreased cellular trehalose-6P level" EXACT [PomBase:al] synonym: "reduced cellular trehalose 6-phosphate level" EXACT [PomBase:mah] is_a: FYPO:0001447 ! decreased cellular trehalose level intersection_of: PATO:0001163 ! decreased concentration intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:18283 ! alpha,alpha-trehalose 6-phosphate relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:18283 ! alpha,alpha-trehalose 6-phosphate created_by: midori creation_date: 2013-09-18T11:48:34Z [Term] id: FYPO:0002661 name: decreased cellular trehalose 6-phosphate level during heat shock def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of trehalose 6-phosphate measured in a cell is lower than normal when the cell is subject to heat shock." [PomBase:mah] synonym: "decreased cellular trehalose 6-phosphate level during heat shock during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular trehalose 6-phosphate level during vegetative growth and during heat shock" EXACT [PomBase:mah] synonym: "decreased cellular trehalose-6P level during heat shock" EXACT [PomBase:al] synonym: "decreased trehalose 6-phosphate accumulation during heat shock" RELATED [PomBase:mah] synonym: "reduced cellular trehalose 6-phosphate level during heat shock" EXACT [PomBase:mah] is_a: FYPO:0002660 ! decreased cellular trehalose 6-phosphate level created_by: midori creation_date: 2013-09-18T11:50:45Z [Term] id: FYPO:0002662 name: decreased cellular trehalose level during heat shock def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of trehalose measured in a cell is lower than normal when the cell is subject to heat shock." [PomBase:mah] synonym: "decreased cellular trehalose level during heat shock during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular trehalose level during vegetative growth and during heat shock" EXACT [PomBase:mah] synonym: "decreased trehalose accumulation during heat shock" RELATED [PomBase:mah] synonym: "reduced cellular trehalose level during heat shock" EXACT [PomBase:mah] is_a: FYPO:0001447 ! decreased cellular trehalose level created_by: midori creation_date: 2013-09-18T11:57:16Z [Term] id: FYPO:0002663 name: alpha,alpha-trehalase activity increase abolished during cellular response to hydrogen peroxide def: "A molecular function phenotype in which the observed rate of alpha,alpha-trehalase activity does not increase as a result of a hydrogen peroxide stimulus." [PomBase:mah] synonym: "absent increase in trehalase activity following hydrogen peroxide stimulus" EXACT [PomBase:al] synonym: "alpha,alpha-trehalase activity increase abolished during cellular response to H2O2" EXACT [PomBase:mah] synonym: "neutral trehalase activity increase abolished during cellular response to hydrogen peroxide" EXACT [PomBase:mah] synonym: "trehalase activity increase abolished during cellular response to hydrogen peroxide" BROAD [GO:0004555, GO:0015927] is_a: FYPO:0001479 ! abnormal alpha,alpha-trehalase activity is_a: FYPO:0001484 ! abnormal cellular response to nutrient created_by: midori creation_date: 2013-09-18T12:19:11Z [Term] id: FYPO:0002664 name: increased level of stress responsive gene mRNA during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more messenger RNAs that are normally expressed during a cellular response to stress measured in a cell is higher than normal (i.e. higher than observed in wild-type cells during vegetative growth)." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "increased level of cellular response to stress responsive gene mRNA" EXACT [PomBase:al] synonym: "increased level of stress responsive gene mRNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased level of stress responsive gene transcripts during vegetative growth" EXACT [PomBase:vw] synonym: "increased mRNA level of stress responsive genes during vegetative growth" EXACT [PomBase:al] synonym: "increased stress responsive gene mRNA accumulation during vegetative growth" RELATED [PomBase:mah] is_a: FYPO:0002936 ! increased mRNA level during vegetative growth is_a: FYPO:0004363 ! altered level of stress responsive gene mRNA during vegetative growth created_by: midori creation_date: 2013-09-18T16:06:04Z [Term] id: FYPO:0002665 name: abnormal peptide-serine-N-acetyltransferase activity def: "A molecular function phenotype in which the observed rate of peptide-serine-N-acetyltransferase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:1990189 ! peptide-serine-N-acetyltransferase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:1990189 ! peptide-serine-N-acetyltransferase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-09-18T16:08:31Z [Term] id: FYPO:0002666 name: abolished peptide-serine-N-acetyltransferase activity def: "A molecular function phenotype in which peptide-serine-N-acetyltransferase activity is absent." [PomBase:mah] synonym: "peptide-serine-N-acetyltransferase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0002665 ! abnormal peptide-serine-N-acetyltransferase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:1990189 ! peptide-serine-N-acetyltransferase activity relationship: towards GO:1990189 ! peptide-serine-N-acetyltransferase activity created_by: midori creation_date: 2013-09-18T16:08:47Z [Term] id: FYPO:0002667 name: decreased peptide-serine-N-acetyltransferase activity def: "A molecular function phenotype in which the observed rate of peptide-serine-N-acetyltransferase activity is decreased." [PomBase:mah] synonym: "reduced peptide-serine-N-acetyltransferase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0002665 ! abnormal peptide-serine-N-acetyltransferase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:1990189 ! peptide-serine-N-acetyltransferase activity relationship: inheres_in GO:1990189 ! peptide-serine-N-acetyltransferase activity created_by: midori creation_date: 2013-09-18T16:09:01Z [Term] id: FYPO:0002668 name: normal peptide-serine-N-acetyltransferase activity def: "A molecular function phenotype in which the observed rate of peptide-serine-N-acetyltransferase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:1990189 ! peptide-serine-N-acetyltransferase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:1990189 ! peptide-serine-N-acetyltransferase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-09-18T16:12:26Z [Term] id: FYPO:0002669 name: abnormal peptide-glutamate-N-acetyltransferase activity def: "A molecular function phenotype in which the observed rate of peptide-glutamate-N-acetyltransferase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:1990190 ! peptide-glutamate-N-acetyltransferase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:1990190 ! peptide-glutamate-N-acetyltransferase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-09-18T16:13:17Z [Term] id: FYPO:0002670 name: increased peptide-glutamate-N-acetyltransferase activity def: "A molecular function phenotype in which the observed rate of peptide-glutamate-N-acetyltransferase activity is increased." [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0002669 ! abnormal peptide-glutamate-N-acetyltransferase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:1990190 ! peptide-glutamate-N-acetyltransferase activity relationship: inheres_in GO:1990190 ! peptide-glutamate-N-acetyltransferase activity created_by: midori creation_date: 2013-09-18T16:13:24Z [Term] id: FYPO:0002671 name: increased concentration of protein in growth medium def: "A phenotype in which the concentration of one or more proteins released into the growth medium by cells is higher than normal." [PomBase:mah] synonym: "increased concentration of proteins in growth medium" EXACT [PomBase:al] synonym: "increased level of protein in growth medium" EXACT [PomBase:mah] synonym: "increased release of protein into growth medium" RELATED [PomBase:mah] is_a: FYPO:0000800 ! increased concentration of substance in growth medium intersection_of: PATO:0001162 ! increased concentration intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: towards CHEBI:36080 ! protein relationship: inheres_in BTO:0000316 ! culture medium relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2013-09-18T16:26:49Z [Term] id: FYPO:0002672 name: normal growth on rapamycin def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing rapamycin." [PomBase:mah] synonym: "normal cell population growth in presence of rapamycin" EXACT [PomBase:mah] synonym: "normal cell population growth on rapamycin" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to rapamycin" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on rapamycin" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:9168 ! sirolimus relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:9168 ! sirolimus created_by: midori creation_date: 2013-09-18T16:35:24Z [Term] id: FYPO:0002673 name: normal growth on torin1 def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing torin1." [PomBase:mah] synonym: "normal cell population growth in presence of torin1" EXACT [PomBase:mah] synonym: "normal cell population growth on torin1" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to torin1" RELATED [PomBase:al, PomBase:mah] synonym: "normal growth on torin 1" EXACT [PomBase:mah] synonym: "normal vegetative cell population growth on torin1" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:84327 ! torin 1 relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:84327 ! torin 1 created_by: midori creation_date: 2013-09-18T16:36:46Z [Term] id: FYPO:0002674 name: normal protein localization to plasma membrane def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the plasma membrane is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to plasma membrane" EXACT [PomBase:mah] synonym: "normal protein localization to plasma membrane during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to plasma membrane during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000644 ! normal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072659 ! protein localization to plasma membrane intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072659 ! protein localization to plasma membrane relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-09-18T16:43:41Z [Term] id: FYPO:0002675 name: increased cellular dTDP level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of dTDP measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular dTDP level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular dTDP level during vegetative growth" EXACT [PomBase:mah] synonym: "increased dTDP accumulation" RELATED [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:18075 ! dTDP relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:18075 ! dTDP created_by: midori creation_date: 2013-09-18T16:45:22Z [Term] id: FYPO:0002676 name: dTTP absent from cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of dTTP measured in a cell is too low to detect." [PomBase:mah] synonym: "dTTP absent from cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "dTTP absent from cell during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001208 ! substance absent from cell during vegetative growth is_a: FYPO:0002572 ! decreased cellular dTTP level intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:18077 ! dTTP relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:18077 ! dTTP created_by: midori creation_date: 2013-09-18T16:46:00Z [Term] id: FYPO:0002677 name: abnormal protein phosphorylation def: "A cellular process phenotype in which the phosphorylation of one or more specific proteins is abnormal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. is_a: FYPO:0002494 ! abnormal protein modification intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0006468 ! protein phosphorylation intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0006468 ! protein phosphorylation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-09-19T11:41:10Z [Term] id: FYPO:0002678 name: abolished protein phosphorylation def: "A cellular process phenotype in which the phosphorylation of one or more specific proteins, or of specific protein sites, does not occur." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "protein phosphorylation abolished" EXACT [PomBase:mah] is_a: FYPO:0002497 ! abolished protein modification is_a: FYPO:0002677 ! abnormal protein phosphorylation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0006468 ! protein phosphorylation relationship: towards GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2013-09-19T11:42:17Z [Term] id: FYPO:0002679 name: decreased protein phosphorylation def: "A cellular process phenotype in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "reduced protein phosphorylation" EXACT [PomBase:mah] is_a: FYPO:0002498 ! decreased protein modification is_a: FYPO:0002677 ! abnormal protein phosphorylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2013-09-19T11:56:10Z [Term] id: FYPO:0002680 name: increased protein phosphorylation def: "A cellular process phenotype in which the phosphorylation of one or more specific proteins occurs to a greater extent than normal." [PomBase:mah] is_a: FYPO:0002499 ! increased protein modification is_a: FYPO:0002677 ! abnormal protein phosphorylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2013-09-19T12:00:31Z [Term] id: FYPO:0002681 name: increased protein phosphorylation during nitrogen starvation def: "A cellular process phenotype in which the phosphorylation of one or more specific proteins occurs to a greater extent than normal when the cell is subject to nitrogen starvation." [PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "increased protein phosphorylation during nitrogen depletion" EXACT [PomBase:vw] synonym: "increased protein phosphorylation during nitrogen deprivation" EXACT [PomBase:vw] is_a: FYPO:0002680 ! increased protein phosphorylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2013-09-19T12:04:02Z [Term] id: FYPO:0002682 name: increased resistance to chemical def: "A phenotype in which cells in a population show increased resistance to a chemical stimulus. Resistance to a chemical is usually measured by determining the maximum concentration of the chemical at which a population of cells grow and divide." [PomBase:mah] synonym: "resistance to chemicals: increased" EXACT [SGD:phenotype_annotation] synonym: "resistant to chemical" EXACT [PomBase:mah] is_a: FYPO:0000139 ! cell population growth phenotype created_by: midori creation_date: 2013-09-19T12:14:30Z [Term] id: FYPO:0002683 name: increased sensitivity to chemical def: "A phenotype in which cells in a population show decreased resistance to a chemical stimulus. Resistance to a chemical is measured by determining the maximum concentration of the chemical at which a population of cells grow and divide. Typically, cells are deemed sensitive to a chemical if they stop growing (and may die) at a concentration of the chemical that allows wild type cells to grow." [PomBase:mah] synonym: "resistance to chemicals: decreased" EXACT [SGD:phenotype_annotation] synonym: "sensitive to chemical" EXACT [PomBase:mah] is_a: FYPO:0000139 ! cell population growth phenotype created_by: midori creation_date: 2013-09-19T12:14:37Z [Term] id: FYPO:0002684 name: sensitive to phlorizin during spore germination def: "A phenotype in which germinating spores show increased sensitivity to phlorizin. Cells stop growing (and may die) at a concentration of phlorizin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to phlorizin" EXACT [PomBase:mah] synonym: "sensitive to phloridzin during spore germination" EXACT [CHEBI:8113, PomBase:mah] is_a: FYPO:0002683 ! increased sensitivity to chemical intersection_of: FYPO:0002683 ! increased sensitivity to chemical intersection_of: during GO:0009847 ! spore germination intersection_of: towards CHEBI:8113 ! phlorizin relationship: during GO:0009847 ! spore germination relationship: towards CHEBI:8113 ! phlorizin created_by: midori creation_date: 2013-09-19T12:58:01Z [Term] id: FYPO:0002685 name: increased cellular trehalose level def: "A cell phenotype in which the amount of trehalose measured in a cell is higher than normal." [PomBase:mah] synonym: "increased trehalose accumulation" RELATED [PomBase:mah] is_a: FYPO:0000990 ! increased level of substance in cell is_a: FYPO:0001446 ! altered cellular trehalose level intersection_of: PATO:0001162 ! increased concentration intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:27082 ! trehalose relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:27082 ! trehalose created_by: midori creation_date: 2013-09-19T13:33:21Z [Term] id: FYPO:0002686 name: increased cellular trehalose level in spore def: "A cell phenotype in which the amount of trehalose measured in a spore is higher than normal." [PomBase:mah] synonym: "increased trehalose accumulation in spore" RELATED [PomBase:mah] is_a: FYPO:0001444 ! increased cellular trehalose level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: inheres_in CL:0000596 ! sexual spore intersection_of: towards CHEBI:27082 ! trehalose relationship: inheres_in CL:0000596 ! sexual spore relationship: towards CHEBI:27082 ! trehalose created_by: midori creation_date: 2013-09-19T13:34:04Z [Term] id: FYPO:0002687 name: normal telomere length def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which telomere length is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal telomere length during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal telomere length during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001313 ! normal subcellular component during vegetative growth is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000781 ! chromosome, telomeric region intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000781 ! chromosome, telomeric region relationship: part_of FYPO:0002155 ! normal telomere structure relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-09-19T14:08:05Z [Term] id: FYPO:0002688 name: mitotic spindle collapse def: "A cell phenotype in which a short mitotic spindle assembles, but does not elongate. The spindle pole bodies fail to separate, and often become spatially closer together, suggesting that the spindle shrinks." [PMID:23885124, PomBase:mah] synonym: "SPB convergence" EXACT [PMID:23885124] synonym: "spindle pole body convergence" EXACT [PMID:23885124] synonym: "unstable mitotic spindle" EXACT [PMID:23885124] is_a: FYPO:0000177 ! abnormal mitotic spindle assembly created_by: midori creation_date: 2013-09-19T14:15:09Z [Term] id: FYPO:0002689 name: sensitive to cumene hydroperoxide def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to cumene hydroperoxide. Cells stop growing (and may die) at a concentration of cumene hydroperoxide that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to cumene hydroperoxide" EXACT [PomBase:mah] synonym: "sensitive to cumene hydroperoxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to cumene hydroperoxide during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:78673 ! cumene hydroperoxide relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:78673 ! cumene hydroperoxide created_by: midori creation_date: 2013-09-19T14:48:08Z [Term] id: FYPO:0002690 name: normal growth on cumene hydroperoxide def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing cumene hydroperoxide." [PomBase:mah] synonym: "normal cell population growth in presence of cumene hydroperoxide" EXACT [PomBase:mah] synonym: "normal cell population growth on cumene hydroperoxide" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to cumene hydroperoxide" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on cumene hydroperoxide" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:78673 ! cumene hydroperoxide relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:78673 ! cumene hydroperoxide created_by: midori creation_date: 2013-09-19T15:00:38Z [Term] id: FYPO:0002691 name: normal growth on menadione def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing menadione." [PomBase:mah] synonym: "normal cell population growth in presence of menadione" EXACT [PomBase:mah] synonym: "normal cell population growth on menadione" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to menadione" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on menadione" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:28869 ! menadione relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:28869 ! menadione created_by: midori creation_date: 2013-09-19T15:04:33Z [Term] id: FYPO:0002692 name: sensitive to paraquat def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to paraquat. Cells stop growing (and may die) at a concentration of paraquat that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to paraquat" EXACT [PomBase:mah] synonym: "sensitive to paraquat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to paraquat during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:34905 ! paraquat relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:34905 ! paraquat created_by: midori creation_date: 2013-09-19T15:15:08Z [Term] id: FYPO:0002693 name: resistance to diamide def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of diamide (N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide) than normal." [PomBase:mah] synonym: "resistance to diamide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to diamide during vegetative growth" EXACT [PomBase:mah] synonym: "resistance to N,N,N',N'-tetramethyldiazene-1,2-dicarboxamide" EXACT [CHEBI:48958] synonym: "resistant to diamide" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:48958 ! 1,1'-azobis(N,N-dimethylformamide) relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:48958 ! 1,1'-azobis(N,N-dimethylformamide) created_by: midori creation_date: 2013-09-19T15:17:54Z [Term] id: FYPO:0002694 name: resistance to hygromycin B def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of hygromycin B than normal." [PomBase:mah] synonym: "resistance to hygromycin B during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to hygromycin B during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to hygromycin B" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:16976 ! hygromycin B relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:16976 ! hygromycin B created_by: midori creation_date: 2013-09-19T15:19:33Z [Term] id: FYPO:0002695 name: abnormal methylenetetrahydrofolate reductase (NADPH) activity def: "A molecular function phenotype in which the observed rate of methylenetetrahydrofolate reductase (NADPH) activity is abnormal." [PomBase:mah] is_a: FYPO:0000689 ! abnormal oxidoreductase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004489 ! methylenetetrahydrofolate reductase (NAD(P)H) activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004489 ! methylenetetrahydrofolate reductase (NAD(P)H) activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-09-19T15:31:14Z [Term] id: FYPO:0002696 name: abolished methylenetetrahydrofolate reductase (NADPH) activity def: "A molecular function phenotype in which methylenetetrahydrofolate reductase (NADPH) activity is absent." [PomBase:mah] synonym: "methylenetetrahydrofolate reductase (NADPH) activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0002695 ! abnormal methylenetetrahydrofolate reductase (NADPH) activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0004489 ! methylenetetrahydrofolate reductase (NAD(P)H) activity relationship: towards GO:0004489 ! methylenetetrahydrofolate reductase (NAD(P)H) activity created_by: midori creation_date: 2013-09-19T15:31:23Z [Term] id: FYPO:0002697 name: decreased methylenetetrahydrofolate reductase (NADPH) activity def: "A molecular function phenotype in which the observed rate of methylenetetrahydrofolate reductase (NADPH) activity is decreased." [PomBase:mah] synonym: "reduced methylenetetrahydrofolate reductase (NADPH) activity" EXACT [PomBase:mah] is_a: FYPO:0000690 ! decreased oxidoreductase activity is_a: FYPO:0002695 ! abnormal methylenetetrahydrofolate reductase (NADPH) activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004489 ! methylenetetrahydrofolate reductase (NAD(P)H) activity relationship: inheres_in GO:0004489 ! methylenetetrahydrofolate reductase (NAD(P)H) activity created_by: midori creation_date: 2013-09-19T15:31:43Z [Term] id: FYPO:0002698 name: increased methylenetetrahydrofolate reductase (NADPH) activity def: "A molecular function phenotype in which the observed rate of methylenetetrahydrofolate reductase (NADPH) activity is increased." [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0002695 ! abnormal methylenetetrahydrofolate reductase (NADPH) activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0004489 ! methylenetetrahydrofolate reductase (NAD(P)H) activity relationship: inheres_in GO:0004489 ! methylenetetrahydrofolate reductase (NAD(P)H) activity created_by: midori creation_date: 2013-09-19T15:32:15Z [Term] id: FYPO:0002699 name: decreased protein localization to actomyosin contractile ring def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the actomyosin contractile ring is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to actomyosin contractile ring" EXACT [PomBase:mah] synonym: "decreased protein localization to actomyosin contractile ring during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to actomyosin contractile ring during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein localization to actomyosin contractile ring involved in mitotic cytokinesis" EXACT [GO:1904498] synonym: "decreased protein localization to cytokinetic contractile ring" EXACT [PomBase:vw] synonym: "decreased protein localization to mitotic contractile ring" EXACT [PomBase:vw] synonym: "reduced protein localization to actomyosin contractile ring" EXACT [PomBase:mah] is_a: FYPO:0000929 ! decreased protein localization to cell cortex is_a: FYPO:0002560 ! abnormal protein localization to actomyosin contractile ring is_a: FYPO:0002869 ! decreased protein localization to cell division site intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1904498 ! protein localization to actomyosin contractile ring involved in mitotic cytokinesis relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1904498 ! protein localization to actomyosin contractile ring involved in mitotic cytokinesis created_by: midori creation_date: 2013-09-19T15:36:39Z [Term] id: FYPO:0002700 name: increased protein kinase activity def: "A molecular function phenotype in which the observed rate of a protein kinase activity is increased." [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0001381 ! abnormal protein kinase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0004672 ! protein kinase activity relationship: inheres_in GO:0004672 ! protein kinase activity created_by: midori creation_date: 2013-09-19T16:06:33Z [Term] id: FYPO:0002701 name: sensitive to torin1 def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to torin1. Cells stop growing (and may die) at a concentration of torin1 that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to torin1" EXACT [PomBase:mah] synonym: "sensitive to torin 1" EXACT [PomBase:mah] synonym: "sensitive to torin1 during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to torin1 during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:84327 ! torin 1 relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:84327 ! torin 1 created_by: midori creation_date: 2013-09-19T16:16:01Z [Term] id: FYPO:0002702 name: circularized chromosome def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which one or more chromosomes forms a circle by fusion of its ends." [PMID:11349150, PomBase:mah] synonym: "circular chromosomes" EXACT [PomBase:mah] synonym: "circularised chromosome" EXACT [PomBase:mah] synonym: "circularized chromosome during mitotic cell cycle" RELATED [PomBase:mah] synonym: "circularized chromosome during vegetative growth" EXACT [PomBase:mah] synonym: "fused telomeres" RELATED [PomBase:mah] synonym: "telomere end fusion" RELATED [PomBase:mah] synonym: "telomeres fused" RELATED [PomBase:mah] is_a: FYPO:0000848 ! abnormal chromosome morphology created_by: midori creation_date: 2013-09-25T12:14:38Z [Term] id: FYPO:0002703 name: increased protein level in autophagosome def: "A cell phenotype in which the amount of protein measured in autophagosomes is higher than normal when the cell is in the vegetative growth phase of the life cycle. Total protein or a specific protein may be affected." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased autophagosomal protein level during vegetative growth" EXACT [PomBase:mah] synonym: "increased protein level in autophagic vacuole during vegetative growth" EXACT [GO:0005776] synonym: "increased protein level in autophagosome during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein level in autophagosome during vegetative growth" EXACT [PomBase:mah] synonym: "protein accumulation in autophagosomes" EXACT [PomBase:vw] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: FYPO:0001327 ! increased protein level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005776 ! autophagosome intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005776 ! autophagosome relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2013-09-25T12:39:09Z [Term] id: FYPO:0002704 name: normal autophagic vacuole docking def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which autophagic vacuole docking is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000627 ! normal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0016240 ! autophagosome docking intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0016240 ! autophagosome docking relationship: part_of FYPO:0000385 ! normal autophagy relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-09-25T12:41:21Z [Term] id: FYPO:0002705 name: sensitive to methionine def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to methionine. Cells stop growing (and may die) at a concentration of methionine that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to methionine" EXACT [PomBase:mah] synonym: "sensitive to methionine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to methionine during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:16643 ! L-methionine relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:16643 ! L-methionine created_by: midori creation_date: 2013-09-25T12:50:43Z [Term] id: FYPO:0002706 name: resistance to cordycepin def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of cordycepin than normal." [PomBase:mah] synonym: "resistance to cordycepin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to cordycepin during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to cordycepin" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:29014 ! cordycepin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:29014 ! cordycepin created_by: midori creation_date: 2013-09-25T13:04:40Z [Term] id: FYPO:0002707 name: normal growth on cordycepin def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing cordycepin." [PomBase:mah] synonym: "normal cell population growth in presence of cordycepin" EXACT [PomBase:mah] synonym: "normal cell population growth on cordycepin" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to cordycepin" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on cordycepin" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:29014 ! cordycepin relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:29014 ! cordycepin created_by: midori creation_date: 2013-09-25T13:07:13Z [Term] id: FYPO:0002708 name: abolished prospore formation def: "A cellular process phenotype in which prospore formation does not occur. In prospore formation, each haploid nucleus becomes encapsulated by a double membrane." [PomBase:mah] comment: This term can be used to describe mutants in which meiotic nuclear division takes place, forming four haploid nuclei, but ascospores do not form around the nuclei. synonym: "abolished ascospore-type prospore assembly" EXACT [GO:0032121] synonym: "abolished forespore formation" EXACT [PomBase:mah] synonym: "forespore formation abolished" EXACT [PomBase:mah] is_a: FYPO:0000196 ! abnormal prospore formation is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0032121 ! attachment of telomeric heterochromatin to spindle pole body relationship: towards GO:0032121 ! attachment of telomeric heterochromatin to spindle pole body created_by: midori creation_date: 2013-09-25T14:36:01Z [Term] id: FYPO:0002709 name: spindle pole body absent from cell def: "A cell phenotype in which the cell does not contain a detectable spindle pole body." [PomBase:mah] synonym: "absent spindle pole body" EXACT [PomBase:mah] is_a: FYPO:0000287 ! abnormal subcellular component is_a: PATO:0002000 ! lacks all parts of type intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards GO:0005816 ! spindle pole body relationship: inheres_in CL:0000000 ! cell relationship: towards GO:0005816 ! spindle pole body created_by: midori creation_date: 2013-09-25T14:46:19Z [Term] id: FYPO:0002710 name: spindle pole body absent from cell after meiosis II def: "A cell phenotype in which nuclei formed by the second meiotic division do not contain detectable spindle pole bodies." [PomBase:mah] synonym: "absent spindle pole body after meiosis II" EXACT [PomBase:mah] synonym: "absent spindle pole body after second meiotic division" EXACT [PomBase:vw] is_a: FYPO:0002709 ! spindle pole body absent from cell created_by: midori creation_date: 2013-09-25T14:48:18Z [Term] id: FYPO:0002711 name: abnormal nuclear separation after meiosis def: "A cellular process phenotype in which the haploid nuclei formed by meiotic division do not separate normally. Nuclei may be closer together than normal, or remain attached by an incompletely separated outer nuclear membrane, or both." [PMID:1417417, PomBase:mah] synonym: "abnormal nuclear distribution after meiosis" EXACT [PomBase:mah] synonym: "abnormal nuclear separation during sporulation" RELATED [PomBase:mah] synonym: "abnormal nuclear separation in ascus" EXACT [PomBase:mah] synonym: "abnormal separation of nuclei in ascus" EXACT [PomBase:vw] is_a: FYPO:0000121 ! abnormal sporulation created_by: midori creation_date: 2013-09-25T14:53:56Z [Term] id: FYPO:0002712 name: decreased DNA recombination def: "A cellular process phenotype in which the occurrence of DNA recombination is decreased." [PomBase:mah] synonym: "decreased DNA recombination frequency" EXACT [PomBase:mah] synonym: "decreased DNA recombination rate" RELATED [PomBase:mah] synonym: "decreased recombination" EXACT [PomBase:vw] synonym: "reduced DNA recombination" EXACT [PomBase:mah] is_a: FYPO:0000063 ! abnormal DNA recombination is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0006310 ! DNA recombination relationship: inheres_in GO:0006310 ! DNA recombination created_by: midori creation_date: 2013-09-25T15:43:00Z [Term] id: FYPO:0002713 name: decreased DNA recombination at mating type locus def: "A cellular process phenotype in which the occurrence of DNA recombination is decreased at the mating type locus." [PomBase:mah] synonym: "decreased DNA recombination frequency at mating type locus" EXACT [PomBase:mah] synonym: "decreased DNA recombination rate at mating type locus" RELATED [PomBase:mah] synonym: "decreased recombination at mating type locus" EXACT [PomBase:vw] synonym: "reduced DNA recombination at mating type locus" EXACT [PomBase:mah] is_a: FYPO:0002712 ! decreased DNA recombination intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0006310 ! DNA recombination intersection_of: occurs_at SO:0001789 ! mating_type_region relationship: inheres_in GO:0006310 ! DNA recombination relationship: occurs_at SO:0001789 ! mating_type_region created_by: midori creation_date: 2013-09-25T15:46:03Z [Term] id: FYPO:0002714 name: protein mislocalized to Golgi apparatus def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a protein that is not normally found in the Golgi apparatus is observed there." [PomBase:mah] comment: Note that this term can be used to annotate any case where a protein is found in the Golgi in a mutant, but not in wild type. In some cases, there may be enough additional information to annotate to 'abnormal protein localization' (FYPO:0000443) or one of its descendants. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "ectopic protein localization to Golgi apparatus" EXACT [PomBase:vw] synonym: "protein mislocalised to Golgi apparatus" EXACT [PomBase:mah] synonym: "protein mislocalised to Golgi apparatus during vegetative growth" EXACT [PomBase:mah] synonym: "protein mislocalized to Golgi apparatus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein mislocalized to Golgi apparatus during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000782 ! mislocalized protein during vegetative growth intersection_of: PATO:0000628 ! mislocalised intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CHEBI:36080 ! protein intersection_of: towards GO:0005794 ! Golgi apparatus relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CHEBI:36080 ! protein relationship: towards GO:0005794 ! Golgi apparatus created_by: midori creation_date: 2013-09-25T15:52:17Z [Term] id: FYPO:0002715 name: normal Golgi apparatus morphology def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, and structure the Golgi apparatus is normal." [PomBase:mah] comment: Note that an abnormal Golgi organization process may, but does not necessarily, result in abnormal Golgi morphology. synonym: "normal Golgi apparatus morphology during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal Golgi apparatus morphology during vegetative growth" EXACT [PomBase:mah] synonym: "normal Golgi morphology" EXACT [PomBase:mah] is_a: FYPO:0001313 ! normal subcellular component during vegetative growth is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005794 ! Golgi apparatus intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005794 ! Golgi apparatus relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-09-25T15:53:38Z [Term] id: FYPO:0002716 name: normal vacuole fusion def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which vacuole fusion, the merging of two vacuole membranes to form a single vacuole, is normal (i.e. indistinguishable from wild type)." [GO:0042144, PomBase:mah] synonym: "normal homotypic vacuole fusion" EXACT [GO:0042144] synonym: "normal vacuole fusion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal vacuole fusion during vegetative growth" EXACT [PomBase:mah] synonym: "normal vacuole fusion, non-autophagic" EXACT [GO:0042144] is_a: FYPO:0001319 ! normal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0042144 ! vacuole fusion, non-autophagic intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0042144 ! vacuole fusion, non-autophagic relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-09-26T11:47:38Z [Term] id: FYPO:0002717 name: normal vacuole fusion during cellular hypotonic response def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which vacuole fusion is normal (i.e. indistinguishable from wild type) during a cellular response to a hypotonic environment." [PomBase:mah] synonym: "normal homotypic vacuole fusion during cellular hypotonic response" EXACT [GO:0042144] synonym: "normal vacuole fusion during cellular hypotonic response during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal vacuole fusion during cellular hypotonic response during vegetative growth" EXACT [PomBase:mah] synonym: "normal vacuole fusion during hypotonic stress" EXACT [PomBase:al] synonym: "normal vacuole fusion, non-autophagic, during cellular hypotonic response" EXACT [GO:0042144] is_a: FYPO:0002716 ! normal vacuole fusion intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0071476 ! cellular hypotonic response intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0042144 ! vacuole fusion, non-autophagic intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0071476 ! cellular hypotonic response relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0042144 ! vacuole fusion, non-autophagic relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-09-26T11:49:34Z [Term] id: FYPO:0002718 name: abnormal protein localization to septum def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the cell septum is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found at the septum and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to septum" EXACT [PomBase:mah] synonym: "abnormal protein localization to barrier septum" EXACT [GO:0000935, PomBase:mah] synonym: "abnormal protein localization to cell septum" EXACT [PomBase:al] synonym: "abnormal protein localization to septum during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein localization to septum during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000443 ! abnormal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1902432 ! protein localization to barrier septum intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1902432 ! protein localization to barrier septum relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-09-26T12:13:16Z [Term] id: FYPO:0002719 name: decreased protein localization to septum def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the cell septum is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to septum" EXACT [PomBase:mah] synonym: "decreased protein localization to barrier septum" EXACT [GO:0000935, PomBase:mah] synonym: "decreased protein localization to cell septum" EXACT [PomBase:al] synonym: "decreased protein localization to septum during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to septum during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to septum" EXACT [PomBase:mah] is_a: FYPO:0002718 ! abnormal protein localization to septum is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902432 ! protein localization to barrier septum relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902432 ! protein localization to barrier septum created_by: midori creation_date: 2013-09-26T12:13:26Z [Term] id: FYPO:0002720 name: sensitive to beta-glucanase def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to one or more enzymes that degrades cell wall polysaccharides by hydrolyzing beta-glucan linkages. Cells stop growing (and may die) at a concentration of such enzymes that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to cell wall-degrading enzymes" EXACT [PomBase:mah] synonym: "sensitive to beta-glucanase during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to beta-glucanase during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001190 ! sensitive to cell wall-degrading enzymes created_by: midori creation_date: 2013-09-26T13:22:37Z [Term] id: FYPO:0002721 name: resistance to alpha-glucanase def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration than normal of one or more enzymes that degrades cell wall polysaccharides by hydrolyzing alpha-glucan linkages." [PomBase:mah] synonym: "resistance to alpha-glucanase during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to alpha-glucanase during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to alpha-glucanase" EXACT [PomBase:mah] is_a: FYPO:0001882 ! resistance to cell wall-degrading enzymes created_by: midori creation_date: 2013-09-26T13:59:44Z [Term] id: FYPO:0002722 name: phytochelatin absent from cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of phytochelatin measured in a cell is too low to detect." [PomBase:mah] synonym: "cadystin absent from cell" EXACT [PMID:2894829] synonym: "phytochelatin absent from cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "phytochelatin absent from cell during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001208 ! substance absent from cell during vegetative growth is_a: FYPO:0002829 ! decreased cellular phytochelatin level intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:60836 ! phytochelatin relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:60836 ! phytochelatin created_by: midori creation_date: 2013-09-26T14:05:14Z [Term] id: FYPO:0002723 name: increased cellular pigment accumulation during cellular response to cadmium ion def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of cellular pigment accumulation is increased during a cellular response to cadmium ion." [PomBase:mah] comment: Note that normal cells do not accumulate detectable levels of any pigment; for this reason, FYPO does not include separate terms for 'increased' and 'abnormal' pigment accumulation. Also note that pigment accumulates in the vacuole. This term refers to GO:0033059 'cellular pigmentation', rather than GO:0043482 'cellular pigment accumulation', because GO:0043482 has paths to 'response to stimulus' in GO. synonym: "abnormal cellular pigment accumulation during cellular response to cadmium ion" EXACT [PomBase:mah] synonym: "altered colony color during cellular response to cadmium ion" RELATED [PomBase:al, PomBase:mah] synonym: "altered colony colour during cellular response to cadmium ion" RELATED [PomBase:al, PomBase:mah] synonym: "increased cellular pigment accumulation during cellular response to cadmium" EXACT [PomBase:mah] synonym: "increased cellular pigment accumulation during cellular response to cadmium ion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular pigment accumulation during cellular response to cadmium ion during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000741 ! increased cellular pigment accumulation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0071276 ! cellular response to cadmium ion intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0033059 ! cellular pigmentation relationship: happens_during GO:0071276 ! cellular response to cadmium ion relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0033059 ! cellular pigmentation created_by: midori creation_date: 2013-09-26T14:51:13Z [Term] id: FYPO:0002724 name: inviable after spore germination, single or double cell division, elongated cell def: "A phenotype in which a spore germinates to produce a cell that is longer than normal and undergoes one or two rounds of cell division." [PomBase:mah] synonym: "essential; germinating spore, single or double cell division, elongated cell" RELATED [PomBase:mah] synonym: "inviable following spore germination, single or double cell division, elongated cell" EXACT [PomBase:mah] synonym: "inviable germinated spore, single or double cell division, elongated cell" EXACT [PomBase:mah] is_a: FYPO:0002421 ! inviable after spore germination, single or double cell division, abnormal cell shape created_by: midori creation_date: 2013-09-26T14:54:57Z [Term] id: FYPO:0002725 name: decreased L-aminoadipate-semialdehyde dehydrogenase activity def: "A molecular function phenotype in which the observed rate of L-aminoadipate-semialdehyde dehydrogenase activity is decreased." [PomBase:mah] synonym: "decreased alpha-aminoadipate reductase activity" EXACT [GO:0004043] synonym: "reduced alpha-aminoadipate reductase activity" EXACT [GO:0004043] synonym: "reduced L-aminoadipate-semialdehyde dehydrogenase activity" EXACT [PomBase:mah] is_a: FYPO:0000690 ! decreased oxidoreductase activity is_a: FYPO:0001674 ! abnormal L-aminoadipate-semialdehyde dehydrogenase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004043 ! L-aminoadipate-semialdehyde dehydrogenase activity relationship: inheres_in GO:0004043 ! L-aminoadipate-semialdehyde dehydrogenase activity created_by: midori creation_date: 2013-09-26T15:01:57Z [Term] id: FYPO:0002726 name: abnormal saccharopine dehydrogenase activity def: "A molecular function phenotype in which the observed rate of saccharopine dehydrogenase activity is abnormal." [PomBase:mah] is_a: FYPO:0000689 ! abnormal oxidoreductase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004753 ! saccharopine dehydrogenase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004753 ! saccharopine dehydrogenase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-09-26T15:03:42Z [Term] id: FYPO:0002727 name: decreased saccharopine dehydrogenase activity def: "A molecular function phenotype in which the observed rate of saccharopine dehydrogenase activity is decreased." [PomBase:mah] synonym: "reduced saccharopine dehydrogenase activity" EXACT [PomBase:mah] is_a: FYPO:0000690 ! decreased oxidoreductase activity is_a: FYPO:0002726 ! abnormal saccharopine dehydrogenase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004753 ! saccharopine dehydrogenase activity relationship: inheres_in GO:0004753 ! saccharopine dehydrogenase activity created_by: midori creation_date: 2013-09-26T15:03:52Z [Term] id: FYPO:0002728 name: inviable swollen elongated cell with enlarged nucleus upon entry into stationary phase def: "A cell morphology phenotype in which a vegetative cell is inviable, is swollen, and is longer than normal, and in which the nucleus is larger than normal, when the cell is in a culture entering stationary phase. In a swollen cell, both length and diameter are greater than normal, although the cell is only considered elongated if the length:width ratio is also greater than normal." [PMID:2743431, PomBase:mah] is_a: FYPO:0002083 ! inviable swollen elongated cell with enlarged nucleus created_by: midori creation_date: 2013-09-26T16:56:31Z [Term] id: FYPO:0002729 name: DNA content increased def: "A cell phenotype in which the total amount of DNA in a cell is greater than normal." [PomBase:mah] synonym: "increased DNA content" EXACT [PomBase:mah] synonym: "increased DNA level" EXACT [PomBase:mah] is_a: FYPO:0000990 ! increased level of substance in cell is_a: FYPO:0004320 ! altered DNA level intersection_of: PATO:0001162 ! increased concentration intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:16991 ! deoxyribonucleic acid relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:16991 ! deoxyribonucleic acid created_by: midori creation_date: 2013-10-01T14:10:44Z [Term] id: FYPO:0002730 name: DNA content increased during stationary phase def: "A cell phenotype in which the total amount of DNA in a cell is greater than normal when the cell is in a culture in stationary phase." [PomBase:mah] synonym: "increased DNA content during stationary phase" EXACT [PomBase:mah] synonym: "increased DNA level during stationary phase" EXACT [PomBase:mah] is_a: FYPO:0002729 ! DNA content increased created_by: midori creation_date: 2013-10-01T14:15:45Z [Term] id: FYPO:0002731 name: mononucleate def: "A physical cellular phenotype in which a cell contains a single nucleus." [PomBase:mah] synonym: "mononucleate cell" EXACT [PomBase:mah] is_a: FYPO:0000136 ! cellular physical quality phenotype is_a: PATO:0001407 ! mononucleate intersection_of: PATO:0001407 ! mononucleate intersection_of: inheres_in CL:0000000 ! cell relationship: inheres_in CL:0000000 ! cell created_by: midori creation_date: 2013-10-01T14:26:14Z [Term] id: FYPO:0002732 name: mononucleate cell with increased DNA content during stationary phase def: "A physical cellular phenotype in which a cell contains a single nucleus, and more DNA than normal, when the cell is in a culture in stationary phase." [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: has_part FYPO:0002730 ! DNA content increased during stationary phase intersection_of: has_part FYPO:0002731 ! mononucleate relationship: has_part FYPO:0002730 ! DNA content increased during stationary phase relationship: has_part FYPO:0002731 ! mononucleate created_by: midori creation_date: 2013-10-01T14:28:35Z [Term] id: FYPO:0002733 name: inviable after spore germination, multiple cell divisions, elongated tapered cell def: "A phenotype in which a spore germinates to produce a cell that is elongated and tapered, i.e. tapers at one end to a diameter smaller than the other, undergoes two or more rounds of cell division and then dies." [PomBase:al, PomBase:mah] synonym: "essential; germinating spore, multiple cell divisions, elongated tapered cell" RELATED [PomBase:mah] synonym: "inviable after spore germination, multiple cell divisions, elongated bottle-shaped cell" EXACT [PomBase:vw] synonym: "inviable after spore germination, multiple cell divisions, elongated bottle/skittle cell" EXACT [PomBase:mah] synonym: "inviable after spore germination, multiple cell divisions, elongated skittle-shaped cell" EXACT [PomBase:mah] synonym: "inviable following spore germination, multiple cell divisions, elongated tapered cell" EXACT [PomBase:mah] synonym: "inviable germinated spore, multiple cell divisions, elongated tapered cell" EXACT [PomBase:mah] is_a: FYPO:0002262 ! inviable after spore germination, multiple cell divisions, elongated cell created_by: midori creation_date: 2013-10-01T14:37:15Z [Term] id: FYPO:0002734 name: abnormal cell cycle process def: "A cellular process phenotype in which a cell does not execute a cell cycle process normally. A cell cycle process is any of the processes that form part of the cell cycle, and thereby ensures successive accurate and complete genome replication and chromosome segregation." [GO:0022402, PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate is_a: FYPO:0000011 ! abnormal cell cycle intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0022402 ! cell cycle process intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0022402 ! cell cycle process relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-10-01T15:08:57Z [Term] id: FYPO:0002735 name: abnormal cell cycle phase def: "A cellular process phenotype in which a cell does not proceed normally through a specific cell cycle phase. A cell cycle phase is any of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GO:0022403, PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate is_a: FYPO:0000011 ! abnormal cell cycle intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0022403 ! cell cycle phase intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0022403 ! cell cycle phase relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-10-01T15:09:18Z [Term] id: FYPO:0002736 name: abnormal mitotic cell cycle phase def: "A cellular process phenotype in which a cell does not proceed normally through a specific mitotic cell cycle phase. A mitotic cell cycle phase is any of the distinct periods or stages into which the mitotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GO:0022403, PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate is_a: FYPO:0000059 ! abnormal mitotic cell cycle is_a: FYPO:0002735 ! abnormal cell cycle phase intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0022403 ! cell cycle phase intersection_of: part_of GO:0000278 ! mitotic cell cycle intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0022403 ! cell cycle phase relationship: part_of GO:0000278 ! mitotic cell cycle relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-10-01T15:14:48Z [Term] id: FYPO:0002737 name: abnormal mitotic cell cycle process def: "A cellular process phenotype in which a cell does not execute a mitotic cell cycle process normally. A mitotic cell cycle process is any of the processes that form part of the mitotic cell cycle, and thereby ensures successive accurate and complete genome replication and chromosome segregation during the vegetative growth phase of the life cycle." [GO:0022402, PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate is_a: FYPO:0000059 ! abnormal mitotic cell cycle is_a: FYPO:0002734 ! abnormal cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:1903047 ! mitotic cell cycle process intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:1903047 ! mitotic cell cycle process relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-10-01T15:15:09Z [Term] id: FYPO:0002738 name: abnormal meiotic cell cycle phase def: "A cellular process phenotype in which a cell does not proceed normally through a specific meiotic cell cycle phase. A meiotic cell cycle phase is any of the distinct periods or stages into which the meiotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GO:0022403, PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate is_a: FYPO:0000052 ! abnormal meiotic cell cycle is_a: FYPO:0002735 ! abnormal cell cycle phase intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0022403 ! cell cycle phase intersection_of: part_of GO:0051321 ! meiotic cell cycle intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0022403 ! cell cycle phase relationship: part_of GO:0051321 ! meiotic cell cycle relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-10-01T15:16:12Z [Term] id: FYPO:0002739 name: abnormal meiotic cell cycle process def: "A cellular process phenotype in which a cell does not execute a meiotic cell cycle process normally. A meiotic cell cycle process is any of the processes that form part of the meiotic cell cycle, and thereby ensures successive accurate and complete genome replication and meiotic chromosome segregation." [GO:0022402, PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate is_a: FYPO:0000052 ! abnormal meiotic cell cycle is_a: FYPO:0002734 ! abnormal cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:1903046 ! meiotic cell cycle process intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:1903046 ! meiotic cell cycle process relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-10-01T15:17:46Z [Term] id: FYPO:0002740 name: normal mitotic cell cycle phase def: "A cellular process phenotype in which a cell proceeds normally through a specific mitotic cell cycle phase. A mitotic cell cycle phase is any of the distinct periods or stages into which the mitotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GO:0022403, PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate is_a: FYPO:0000411 ! normal mitotic cell cycle is_a: FYPO:0003833 ! normal cell cycle phase intersection_of: PATO:0000001 ! quality intersection_of: during GO:0000278 ! mitotic cell cycle intersection_of: inheres_in GO:0022403 ! cell cycle phase intersection_of: qualifier PATO:0000461 ! normal relationship: during GO:0000278 ! mitotic cell cycle relationship: inheres_in GO:0022403 ! cell cycle phase relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-10-01T16:02:38Z [Term] id: FYPO:0002741 name: normal mitotic cell cycle process def: "A cellular process phenotype in which a cell executes a mitotic cell cycle process normally. A mitotic cell cycle process is any of the processes that form part of the mitotic cell cycle, and thereby ensures successive accurate and complete genome replication and chromosome segregation." [GO:1903047, PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate is_a: FYPO:0000411 ! normal mitotic cell cycle intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:1903047 ! mitotic cell cycle process intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:1903047 ! mitotic cell cycle process relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-10-01T16:03:12Z [Term] id: FYPO:0002742 name: increased level of iron transport gene RNA during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more iron transport RNAs measured in a cell is higher than normal (i.e. higher than observed in wild-type cells). Iron transport RNAs are transcribed from genes whose products are involved in iron transport." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "increased iron transport gene RNA accumulation during vegetative growth" RELATED [PomBase:mah] synonym: "increased level of iron transport gene RNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased level of iron transport gene transcripts during vegetative growth" EXACT [PomBase:vw] is_a: FYPO:0004490 ! increased level of transport gene RNA during vegetative growth created_by: midori creation_date: 2013-10-01T16:48:00Z [Term] id: FYPO:0002743 name: increased level of amino acid metabolism gene RNA during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more amino acid metabolism RNAs measured in a cell is higher than normal (i.e. higher than observed in wild-type cells). Amino acid metabolism RNAs are transcribed from genes whose products are involved in metabolism of one or more amino acids." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "increased amino acid metabolism gene RNA accumulation during vegetative growth" RELATED [PomBase:mah] synonym: "increased level of amino acid metabolism gene RNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased level of amino acid metabolism gene transcripts during vegetative growth" EXACT [PomBase:vw] is_a: FYPO:0000825 ! increased RNA level during vegetative growth created_by: midori creation_date: 2013-10-01T16:50:06Z [Term] id: FYPO:0002744 name: increased level of amino acid transport gene RNA during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more amino acid transport RNAs measured in a cell is higher than normal (i.e. higher than observed in wild-type cells). Amino acid transport RNAs are transcribed from genes whose products are involved in amino acid transport." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "increased amino acid transport gene RNA accumulation during vegetative growth" RELATED [PomBase:mah] synonym: "increased level of amino acid transport gene RNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased level of amino acid transport gene transcripts during vegetative growth" EXACT [PomBase:vw] is_a: FYPO:0004490 ! increased level of transport gene RNA during vegetative growth created_by: midori creation_date: 2013-10-01T16:50:41Z [Term] id: FYPO:0002745 name: normal cellular proline level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-proline measured in the cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular L-proline level" EXACT [PomBase:mah] synonym: "normal cellular proline level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular proline level during vegetative growth" EXACT [PomBase:mah] synonym: "normal level of proline in cell" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:17203 ! L-proline relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:17203 ! L-proline created_by: midori creation_date: 2013-10-03T13:12:08Z [Term] id: FYPO:0002746 name: normal cellular valine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-valine measured in the cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular L-valine level" EXACT [PomBase:mah] synonym: "normal cellular valine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular valine level during vegetative growth" EXACT [PomBase:mah] synonym: "normal level of valine in cell" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:16414 ! L-valine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:16414 ! L-valine created_by: midori creation_date: 2013-10-03T13:13:20Z [Term] id: FYPO:0002747 name: normal cellular lysine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-lysine measured in the cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular L-lysine level" EXACT [PomBase:mah] synonym: "normal cellular lysine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular lysine level during vegetative growth" EXACT [PomBase:mah] synonym: "normal level of lysine in cell" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:18019 ! L-lysine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:18019 ! L-lysine created_by: midori creation_date: 2013-10-03T13:15:20Z [Term] id: FYPO:0002748 name: decreased cellular alanine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-alanine measured in the cell is lower than normal." [PomBase:mah] synonym: "decreased cellular alanine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular alanine level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased cellular L-alanine level" EXACT [PomBase:mah] synonym: "decreased level of alanine in cell" EXACT [PomBase:mah] synonym: "reduced cellular alanine level" EXACT [PomBase:mah] synonym: "reduced level of alanine in cell" EXACT [PomBase:mah] is_a: FYPO:0003985 ! decreased cellular amino acid level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:16977 ! L-alanine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:16977 ! L-alanine created_by: midori creation_date: 2013-10-03T13:21:32Z [Term] id: FYPO:0002749 name: decreased cellular asparagine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-asparagine measured in the cell is lower than normal." [PomBase:mah] synonym: "decreased cellular asparagine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular asparagine level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased cellular L-asparagine level" EXACT [PomBase:mah] synonym: "decreased level of asparagine in cell" EXACT [PomBase:mah] synonym: "reduced cellular asparagine level" EXACT [PomBase:mah] synonym: "reduced level of asparagine in cell" EXACT [PomBase:mah] is_a: FYPO:0003985 ! decreased cellular amino acid level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:17196 ! L-asparagine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:17196 ! L-asparagine created_by: midori creation_date: 2013-10-03T13:22:39Z [Term] id: FYPO:0002750 name: abnormal sulfate import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of sulfate ions into the cell is abnormal." [PomBase:mah] synonym: "abnormal sulfate import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal sulfate import during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal sulfate import into cell" EXACT [PomBase:al] synonym: "abnormal sulfate ion import" EXACT [PomBase:al] synonym: "abnormal sulfate uptake" EXACT [PomBase:mah] synonym: "abnormal sulphate import" EXACT [PomBase:mah] synonym: "abnormal sulphate ion import" EXACT [PomBase:mah] is_a: FYPO:0001336 ! transport phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0001720 ! abnormal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1902434 ! sulfate import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1902434 ! sulfate import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-10-03T13:39:22Z [Term] id: FYPO:0002751 name: decreased sulfate import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of sulfate ions into the cell occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased sulfate import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased sulfate import during vegetative growth" EXACT [PomBase:mah] synonym: "decreased sulfate import into cell" EXACT [PomBase:al] synonym: "decreased sulfate ion import" RELATED [PomBase:al] synonym: "decreased sulfate uptake" EXACT [PomBase:mah] synonym: "decreased sulphate import" EXACT [PomBase:mah] synonym: "decreased sulphate ion import" EXACT [PomBase:mah] synonym: "reduced sulfate import" EXACT [PomBase:mah] is_a: FYPO:0002750 ! abnormal sulfate import is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902434 ! sulfate import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902434 ! sulfate import into cell created_by: midori creation_date: 2013-10-03T13:39:38Z [Term] id: FYPO:0002752 name: abolished cell population growth on methionine sulfur source def: "A vegetative cell population growth phenotype in which a cell population does not grow in a medium containing L-methionine as the sole sulfur source." [PomBase:mah] comment: Use this term for a population of cells that does not grow with methionine as the sulfur source, but does grow using a different sulfur source (a cell population that does not grow on any media would be considered inviable). Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "abolished cell population growth on methionine sulphur source" EXACT [PomBase:mah] synonym: "abolished growth on methionine sulfur source" BROAD [PomBase:mah] synonym: "abolished methionine utilization" RELATED [PomBase:mah] synonym: "abolished vegetative cell population growth on methionine sulfur source" EXACT [PomBase:mah] synonym: "cell population growth on methionine sulfur source abolished" EXACT [PomBase:mah] synonym: "inability to utilize methionine as sole sulphur source" RELATED [PomBase:al] is_a: FYPO:0001575 ! abolished vegetative cell population growth created_by: midori creation_date: 2013-10-03T14:14:42Z [Term] id: FYPO:0002753 name: abolished cell population growth on sulfate sulfur source def: "A vegetative cell population growth phenotype in which a cell population does not grow in a medium containing sulfate ions as the sole sulfur source." [PomBase:mah] comment: Use this term for a population of cells that does not grow with sulfate as the sulfur source, but does grow using a different sulfur source (a cell population that does not grow on any media would be considered inviable). Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "abolished cell population growth on sulphate sulphur source" EXACT [PomBase:mah] synonym: "abolished growth on sulfate sulfur source" BROAD [PomBase:mah] synonym: "abolished sulfate utilization" RELATED [PomBase:mah] synonym: "abolished vegetative cell population growth on sulfate ion sulfur source" EXACT [PomBase:mah] synonym: "cell population growth on sulfate sulfur source abolished" EXACT [PomBase:mah] synonym: "inability to utilize sulphate as sole sulphur source" RELATED [PomBase:al] is_a: FYPO:0001575 ! abolished vegetative cell population growth intersection_of: FYPO:0001575 ! abolished vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:16189 ! sulfate relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:16189 ! sulfate created_by: midori creation_date: 2013-10-03T14:25:55Z [Term] id: FYPO:0002754 name: abnormal cysteine synthase activity def: "A molecular function phenotype in which the observed rate of cysteine synthase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004124 ! cysteine synthase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004124 ! cysteine synthase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-10-03T14:48:01Z [Term] id: FYPO:0002755 name: decreased cysteine synthase activity def: "A molecular function phenotype in which the observed rate of cysteine synthase activity is decreased." [PomBase:mah] synonym: "reduced cysteine synthase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0002754 ! abnormal cysteine synthase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004124 ! cysteine synthase activity relationship: inheres_in GO:0004124 ! cysteine synthase activity created_by: midori creation_date: 2013-10-03T14:48:20Z [Term] id: FYPO:0002756 name: increased cysteine synthase activity def: "A molecular function phenotype in which the observed rate of cysteine synthase activity is increased." [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0002754 ! abnormal cysteine synthase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0004124 ! cysteine synthase activity relationship: inheres_in GO:0004124 ! cysteine synthase activity created_by: midori creation_date: 2013-10-03T14:48:38Z [Term] id: FYPO:0002757 name: resistance to quinidine def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of quinidine than normal." [PomBase:mah] synonym: "resistance to quinidine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to quinidine during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to quinidine" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:28593 ! quinidine relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:28593 ! quinidine created_by: midori creation_date: 2013-10-03T15:15:54Z [Term] id: FYPO:0002758 name: resistance to 4-nitroquinoline N-oxide def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of 4-nitroquinoline N-oxide than normal." [PomBase:mah] synonym: "resistance to 4-nitroquinoline N-oxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to 4-nitroquinoline N-oxide during vegetative growth" EXACT [PomBase:mah] synonym: "resistance to 4-NQO" EXACT [PomBase:mah] synonym: "resistance to 4NQO" EXACT [PomBase:mah] synonym: "resistant to 4-nitroquinoline N-oxide" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:16907 ! 4-nitroquinoline N-oxide relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:16907 ! 4-nitroquinoline N-oxide created_by: midori creation_date: 2013-10-03T15:16:56Z [Term] id: FYPO:0002759 name: abolished protein localization to pre-autophagosomal structure def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the pre-autophagosomal structure is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to pre-autophagosomal structure" EXACT [PomBase:mah] synonym: "abolished protein localization to PAS" EXACT [GO:0034497] synonym: "abolished protein localization to pre-autophagosomal structure during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to pre-autophagosomal structure during vegetative growth" EXACT [PomBase:mah] synonym: "protein localization to pre-autophagosomal structure abolished" EXACT [PomBase:mah] is_a: FYPO:0001179 ! protein localization abolished during vegetative growth is_a: FYPO:0002614 ! abnormal protein localization to pre-autophagosomal structure intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0034497 ! protein localization to pre-autophagosomal structure relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0034497 ! protein localization to pre-autophagosomal structure created_by: midori creation_date: 2013-10-03T15:39:50Z [Term] id: FYPO:0002760 name: short cytoplasmic microtubules def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells form cytoplasmic microtubules that are shorter than normal." [PomBase:mah] synonym: "short cytoplasmic microtubules during mitotic cell cycle" RELATED [PomBase:mah] synonym: "short cytoplasmic microtubules during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001418 ! abnormal microtubule cytoskeleton morphology during vegetative growth is_a: FYPO:0004088 ! abnormal cytoplasmic microtubules is_a: PATO:0000574 ! decreased length intersection_of: PATO:0000574 ! decreased length intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005881 ! cytoplasmic microtubule relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005881 ! cytoplasmic microtubule created_by: midori creation_date: 2013-10-03T15:37:54Z [Term] id: FYPO:0002761 name: abnormal microtubule bundle formation def: "A cellular process phenotype in which microtubule bundle formation, which normally results in a parallel arrangement of microtubules, is abnormal." [GO:0001578, PomBase:mah] is_a: FYPO:0000054 ! abnormal microtubule cytoskeleton organization intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0001578 ! microtubule bundle formation intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0001578 ! microtubule bundle formation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-10-03T15:53:48Z [Term] id: FYPO:0002762 name: inviable after spore germination, without cell division, spheroid cell def: "A phenotype in which a spore germinates to produce an inviable cell that does not divide, and that is shaped in the form of a spheroid. In spheroid cells, there is much less difference between the long and short axes of the cell than in wild type." [PomBase:mah] synonym: "essential; germinating spore, without cell division, spheroid cell" RELATED [PomBase:mah] synonym: "inviable after spore germination, undivided spheroid cell" EXACT [PomBase:mah] synonym: "inviable following spore germination, without cell division, spheroid cell" EXACT [PomBase:mah] synonym: "inviable germinated spore, without cell division, spheroid cell" EXACT [PomBase:mah] is_a: FYPO:0001991 ! inviable after spore germination, without cell division created_by: midori creation_date: 2013-10-03T16:26:06Z [Term] id: FYPO:0002763 name: abnormal tRNA (guanine(9)-N(1))-methyltransferase activity def: "A molecular function phenotype in which the observed rate of tRNA (guanine(9)-N(1))-methyltransferase activity is abnormal." [PomBase:mah] is_a: FYPO:0001771 ! abnormal tRNA methyltransferase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0052905 ! tRNA (guanine(9)-N(1))-methyltransferase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0052905 ! tRNA (guanine(9)-N(1))-methyltransferase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-10-08T13:42:54Z [Term] id: FYPO:0002764 name: abolished tRNA (guanine(9)-N(1))-methyltransferase activity def: "A molecular function phenotype in which tRNA (guanine(9)-N(1))-methyltransferase activity is absent." [PomBase:mah] synonym: "tRNA (guanine(9)-N(1))-methyltransferase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0001773 ! abolished tRNA methyltransferase activity is_a: FYPO:0002763 ! abnormal tRNA (guanine(9)-N(1))-methyltransferase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0052905 ! tRNA (guanine(9)-N(1))-methyltransferase activity relationship: towards GO:0052905 ! tRNA (guanine(9)-N(1))-methyltransferase activity created_by: midori creation_date: 2013-10-08T13:43:03Z [Term] id: FYPO:0002765 name: decreased tRNA (guanine(9)-N(1))-methyltransferase activity def: "A molecular function phenotype in which the observed rate of tRNA (guanine(9)-N(1))-methyltransferase activity is decreased." [PomBase:mah] synonym: "reduced tRNA (guanine(9)-N(1))-methyltransferase activity" EXACT [PomBase:mah] is_a: FYPO:0001772 ! decreased tRNA methyltransferase activity is_a: FYPO:0002763 ! abnormal tRNA (guanine(9)-N(1))-methyltransferase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0052905 ! tRNA (guanine(9)-N(1))-methyltransferase activity relationship: inheres_in GO:0052905 ! tRNA (guanine(9)-N(1))-methyltransferase activity created_by: midori creation_date: 2013-10-08T13:43:18Z [Term] id: FYPO:0002766 name: resistance to clotrimazole def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of clotrimazole than normal." [PomBase:mah] synonym: "resistance to clotrimazole during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to clotrimazole during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to clotrimazole" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:3764 ! clotrimazole relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:3764 ! clotrimazole created_by: midori creation_date: 2013-10-08T14:25:26Z [Term] id: FYPO:0002767 name: resistance to terbinafine def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of terbinafine than normal." [PomBase:mah] synonym: "resistance to terbinafine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to terbinafine during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to terbinafine" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:9448 ! terbinafine relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:9448 ! terbinafine created_by: midori creation_date: 2013-10-08T14:26:19Z [Term] id: FYPO:0002768 name: decreased protein ubiquitination def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of ubiquitination of one or more specific proteins, or of specific protein sites, is decreased." [PomBase:mah] synonym: "decreased protein ubiquitination during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein ubiquitination during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein ubiquitinylation" EXACT [GO:0016567, PomBase:mah] synonym: "decreased protein ubiquitylation" EXACT [GO:0016567, PomBase:mah] synonym: "reduced protein ubiquitination" EXACT [PomBase:mah] is_a: FYPO:0000545 ! decreased protein modification during vegetative growth is_a: FYPO:0000905 ! abnormal protein ubiquitination intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0016567 ! protein ubiquitination relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0016567 ! protein ubiquitination created_by: midori creation_date: 2013-10-08T14:36:41Z [Term] id: FYPO:0002769 name: abnormal protein localization to spindle pole body def: "A cell phenotype in which the localization of a protein to the spindle pole body is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found at the spindle pole body and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to spindle pole body" EXACT [PomBase:mah] synonym: "abnormal protein localization to SPB" EXACT [PomBase:mah] is_a: FYPO:0004090 ! abnormal protein localization to microtubule cytoskeleton intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0071988 ! protein localization to spindle pole body intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0071988 ! protein localization to spindle pole body relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-10-10T15:20:35Z [Term] id: FYPO:0002770 name: decreased protein localization to spindle pole body def: "A cell phenotype in which the localization of a protein to the spindle pole body is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to spindle pole body" EXACT [PomBase:mah] synonym: "decreased protein localization to SPB" EXACT [PomBase:mah] synonym: "reduced protein localization to spindle pole body" EXACT [PomBase:mah] is_a: FYPO:0002769 ! abnormal protein localization to spindle pole body is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0071988 ! protein localization to spindle pole body relationship: inheres_in GO:0071988 ! protein localization to spindle pole body created_by: midori creation_date: 2013-10-10T15:22:07Z [Term] id: FYPO:0002771 name: abnormal protein localization to meiotic spindle pole body def: "A cell phenotype in which the localization of a protein to the meiotic spindle pole body is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found at the spindle pole body and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to meiotic spindle pole body" EXACT [PomBase:mah] synonym: "abnormal protein localization to meiotic SPB" EXACT [PomBase:mah] is_a: FYPO:0002769 ! abnormal protein localization to spindle pole body is_a: FYPO:0003549 ! abnormal protein localization during meiosis intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:1902441 ! protein localization to meiotic spindle pole body intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:1902441 ! protein localization to meiotic spindle pole body relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-10-10T15:41:12Z [Term] id: FYPO:0002772 name: decreased protein localization to meiotic spindle pole body def: "A cell phenotype in which the localization of a protein to the meiotic spindle pole body is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. Use this term for cells in which in which the re-accumulation of some spindle pole body components does not occur at the onset of meiosis I. synonym: "decreased protein localisation to meiotic spindle pole body" EXACT [PomBase:mah] synonym: "decreased protein localization to meiotic SPB" EXACT [PomBase:mah] synonym: "reduced protein localization to meiotic spindle pole body" EXACT [PomBase:mah] is_a: FYPO:0002770 ! decreased protein localization to spindle pole body is_a: FYPO:0002771 ! abnormal protein localization to meiotic spindle pole body intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:1902441 ! protein localization to meiotic spindle pole body relationship: inheres_in GO:1902441 ! protein localization to meiotic spindle pole body created_by: midori creation_date: 2013-10-10T15:42:17Z [Term] id: FYPO:0002773 name: third meiotic division def: "A cellular process phenotype in which a cell undergoes an abnormal nuclear division after meiosis II is complete." [PMID:23628763, PomBase:mah] synonym: "meiosis III" RELATED [PMID:23628763] synonym: "meiosis termination defect" EXACT [PMID:23628763] is_a: FYPO:0000051 ! abnormal meiosis created_by: midori creation_date: 2013-10-10T15:56:53Z [Term] id: FYPO:0002774 name: increased level of ubiquitinated protein in cell during vegetative growth def: "A cell phenotype in which the amount of ubiquitinated protein measured in the cell is higher than normal when the cell is in the vegetative growth phase of the life cycle. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider also annotating to 'increased protein ubiquitination' (FYPO:0002082) if the experiment directly assays the ubiquitination reaction(s). synonym: "increased accumulation of ubiquitinated protein in cell during vegetative growth" RELATED [PomBase:al] synonym: "increased level of ubiquitinated protein in cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased ubiquitinated protein level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001327 ! increased protein level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards PR:000037077 relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards PR:000037077 created_by: midori creation_date: 2013-10-10T16:03:17Z [Term] id: FYPO:0002775 name: decreased level of sumoylated protein in cell def: "A cell phenotype in which the amount of sumoylated protein measured the cell is higher than normal when the cell is in the vegetative growth phase of the life cycle. Total protein or a specific protein may be affected." [PomBase:mah] synonym: "decreased accumulation of sumoylated protein in cell" RELATED [PomBase:mah] synonym: "decreased level of sumoylated protein in cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased level of sumoylated protein in cell during vegetative growth" EXACT [PomBase:mah] synonym: "decreased sumoylated protein level during vegetative growth" EXACT [PomBase:mah] synonym: "reduced level of sumoylated protein in cell" EXACT [PomBase:mah] is_a: FYPO:0001324 ! decreased protein level during vegetative growth is_a: FYPO:0002703 ! increased protein level in autophagosome intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005776 ! autophagosome intersection_of: towards PR:000037078 relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005776 ! autophagosome relationship: towards PR:000037078 created_by: midori creation_date: 2013-10-10T16:07:19Z [Term] id: FYPO:0002776 name: normal level of sumoylated protein in cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of sumoylated protein measured in a cell is normal (i.e. indistinguishable from wild type). Total protein or a specific protein may be affected." [PomBase:mah] synonym: "normal level of sumoylated protein during vegetative growth" EXACT [PomBase:mah] synonym: "normal level of sumoylated protein in cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal sumoylated protein accumulation" RELATED [PomBase:mah] synonym: "normal sumoylated protein level" EXACT [PomBase:mah] is_a: FYPO:0001258 ! normal protein level during cellular response to hypoxia intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0071456 ! cellular response to hypoxia intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards PR:000037078 relationship: exists_during GO:0071456 ! cellular response to hypoxia relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards PR:000037078 created_by: midori creation_date: 2013-10-10T16:08:53Z [Term] id: FYPO:0002777 name: abnormal protein sumoylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the sumoylation of one or more specific proteins, or of specific protein sites, is abnormal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein sumolation" EXACT [GO:0016925, PomBase:mah] synonym: "abnormal protein sumoylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein sumoylation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000329 ! abnormal protein modification during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0016925 ! protein sumoylation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0016925 ! protein sumoylation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-10-10T16:15:15Z [Term] id: FYPO:0002778 name: decreased protein sumoylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of sumoylation of one or more specific proteins, or of specific protein sites, is decreased." [PomBase:mah] synonym: "decreased protein sumolation" EXACT [GO:0016925, PomBase:mah] synonym: "decreased protein sumoylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein sumoylation during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein sumoylation" EXACT [PomBase:mah] is_a: FYPO:0000545 ! decreased protein modification during vegetative growth is_a: FYPO:0002777 ! abnormal protein sumoylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0016925 ! protein sumoylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0016925 ! protein sumoylation created_by: midori creation_date: 2013-10-10T16:15:25Z [Term] id: FYPO:0002779 name: abolished protein localization to nucleus, with protein mislocalized to cytoplasm def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleus is abolished, and the protein is present in the cytoplasm instead." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to nucleus, with protein mislocalised to cytoplasm" EXACT [PomBase:mah] synonym: "abolished protein localization in nucleus, with protein mislocalized to cytoplasm" EXACT [GO:0072659] synonym: "abolished protein localization to nucleus, with protein mislocalized to cytoplasm during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to nucleus, with protein mislocalized to cytoplasm, during vegetative growth" EXACT [PomBase:mah] synonym: "protein localization to nucleus abolished, with protein mislocalized to cytoplasm" EXACT [PomBase:mah] is_a: FYPO:0001424 ! abolished protein localization to nucleus during vegetative growth intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000783 ! protein mislocalized to cytoplasm intersection_of: towards GO:0034504 ! protein localization to nucleus relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000783 ! protein mislocalized to cytoplasm relationship: towards GO:0034504 ! protein localization to nucleus created_by: midori creation_date: 2013-10-10T16:32:09Z [Term] id: FYPO:0002780 name: decreased cellular reactive oxygen species level during vegetative growth def: "A cell phenotype in which the amount of reactive oxygen species (ROS) measured in a cell is lower than normal in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "decreased cellular reactive oxygen species accumulation during vegetative growth" RELATED [PomBase:mah] synonym: "decreased cellular reactive oxygen species level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular ROS accumulation during vegetative growth" RELATED [PomBase:mah] synonym: "decreased cellular ROS level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased ROS accumulation during vegetative growth" RELATED [PomBase:al] synonym: "reduced cellular reactive oxygen species level during vegetative growth" EXACT [PomBase:mah] synonym: "reduced cellular ROS level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001329 ! decreased level of substance in cell during vegetative growth is_a: FYPO:0002142 ! altered cellular reactive oxygen species level intersection_of: PATO:0001163 ! decreased concentration intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:26523 ! reactive oxygen species relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:26523 ! reactive oxygen species created_by: midori creation_date: 2013-10-10T16:38:51Z [Term] id: FYPO:0002781 name: increased transcription during cellular response to nitric oxide def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription occurs to a greater extent than normal during a cellular response to nitric oxide. All genes, or a specific subset of genes, may be affected." [PomBase:mah] synonym: "increased transcription during cellular response to nitric oxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased transcription during cellular response to nitric oxide during vegetative growth" EXACT [PomBase:mah] synonym: "increased transcription during cellular response to nitric oxide stress" RELATED [PomBase:al] is_a: FYPO:0000780 ! increased transcription during vegetative growth intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0071732 ! cellular response to nitric oxide intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006351 ! transcription, DNA-templated relationship: happens_during GO:0071732 ! cellular response to nitric oxide relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006351 ! transcription, DNA-templated created_by: midori creation_date: 2013-10-10T16:43:03Z [Term] id: FYPO:0002782 name: increased transcription during cellular response to salt stress def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription occurs to a greater extent than normal during a cellular response to a salt stress. All genes, or a specific subset of genes, may be affected." [PomBase:mah] synonym: "increased transcription during cellular response to salt stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased transcription during cellular response to salt stress during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000780 ! increased transcription during vegetative growth intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0071472 ! cellular response to salt stress intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006351 ! transcription, DNA-templated relationship: happens_during GO:0071472 ! cellular response to salt stress relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006351 ! transcription, DNA-templated created_by: midori creation_date: 2013-10-10T16:46:32Z [Term] id: FYPO:0002783 name: decreased transcription during cellular response to nitric oxide def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription occurs to a lower extent than normal during a cellular response to nitric oxide. All genes, or a specific subset of genes, may be affected." [PomBase:mah] synonym: "decreased transcription during cellular response to nitric oxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased transcription during cellular response to nitric oxide during vegetative growth" EXACT [PomBase:mah] synonym: "decreased transcription during cellular response to nitric oxide stress" RELATED [PomBase:al] synonym: "reduced transcription during cellular response to nitric oxide" EXACT [PomBase:mah] is_a: FYPO:0000781 ! decreased transcription during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0071732 ! cellular response to nitric oxide intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006351 ! transcription, DNA-templated relationship: happens_during GO:0071732 ! cellular response to nitric oxide relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006351 ! transcription, DNA-templated created_by: midori creation_date: 2013-10-10T16:48:41Z [Term] id: FYPO:0002784 name: decreased transcription during cellular response to salt stress def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription occurs to a lower extent than normal during a cellular response to a salt stress. All genes, or a specific subset of genes, may be affected." [PomBase:mah] synonym: "decreased transcription during cellular response to salt stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased transcription during cellular response to salt stress during vegetative growth" EXACT [PomBase:mah] synonym: "reduced transcription during cellular response to salt stress" EXACT [PomBase:mah] is_a: FYPO:0000781 ! decreased transcription during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0071472 ! cellular response to salt stress intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006351 ! transcription, DNA-templated relationship: happens_during GO:0071472 ! cellular response to salt stress relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006351 ! transcription, DNA-templated created_by: midori creation_date: 2013-10-10T16:48:48Z [Term] id: FYPO:0002785 name: abolished riboflavin binding def: "A molecular function phenotype in which riboflavin binding by a gene product (usually a protein) in a mutant does not occur. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "riboflavin binding abolished" EXACT [PomBase:mah] is_a: FYPO:0002388 ! abnormal riboflavin binding is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:1902444 ! riboflavin binding relationship: towards GO:1902444 ! riboflavin binding created_by: midori creation_date: 2013-10-16T11:29:42Z [Term] id: FYPO:0002786 name: decreased riboflavin binding def: "A molecular function phenotype in which occurrence of riboflavin binding by a gene product (usually a protein) in a mutant is decreased. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "reduced riboflavin binding" EXACT [PomBase:mah] is_a: FYPO:0002388 ! abnormal riboflavin binding is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:1902444 ! riboflavin binding relationship: inheres_in GO:1902444 ! riboflavin binding created_by: midori creation_date: 2013-10-16T11:29:54Z [Term] id: FYPO:0002787 name: small vacuoles def: "A cell phenotype in which vacuoles are smaller than normal." [PomBase:mah] is_a: FYPO:0002257 ! abnormal vacuolar morphology is_a: PATO:0000596 ! decreased volume intersection_of: PATO:0000596 ! decreased volume intersection_of: inheres_in GO:0000324 ! fungal-type vacuole relationship: inheres_in GO:0000324 ! fungal-type vacuole created_by: midori creation_date: 2013-10-16T11:45:57Z [Term] id: FYPO:0002788 name: small vacuoles during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which vacuoles are smaller than normal." [PomBase:mah] synonym: "small vacuoles during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000368 ! abnormal vacuolar morphology during vegetative growth is_a: FYPO:0002787 ! small vacuoles intersection_of: PATO:0000596 ! decreased volume intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole created_by: midori creation_date: 2013-10-16T11:46:21Z [Term] id: FYPO:0002789 name: small vacuoles during stationary phase def: "A cell phenotype observed when the population in which the cell is found is in stationary phase in which vacuoles are smaller than normal." [PomBase:mah] is_a: FYPO:0002787 ! small vacuoles intersection_of: PATO:0000596 ! decreased volume intersection_of: exists_during GO:0060274 ! maintenance of stationary phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole relationship: exists_during GO:0060274 ! maintenance of stationary phase relationship: inheres_in GO:0000324 ! fungal-type vacuole created_by: midori creation_date: 2013-10-16T11:46:42Z [Term] id: FYPO:0002790 name: vacuoles present in greater numbers def: "A physical cellular phenotype in which cells contain more vacuoles than normal." [PomBase:mah] synonym: "additional vacuoles present" EXACT [PomBase:mah] synonym: "extra vacuoles" EXACT [PomBase:mah] is_a: FYPO:0004638 ! abnormal cellular physical quality phenotype is_a: PATO:0002002 ! has extra parts of type intersection_of: PATO:0002002 ! has extra parts of type intersection_of: towards GO:0000324 ! fungal-type vacuole relationship: towards GO:0000324 ! fungal-type vacuole created_by: midori creation_date: 2013-10-16T15:31:27Z [Term] id: FYPO:0002791 name: small vacuoles present in greater numbers during stationary phase def: "A cell phenotype in which a cell contains more, but smaller, vacuoles than normal when the population in which the cell is found is in stationary phase." [PomBase:mah] synonym: "fragmented vacuoles during stationary phase" RELATED [PomBase:mah] is_a: FYPO:0002258 ! small vacuoles present in greater numbers intersection_of: FYPO:0004638 ! abnormal cellular physical quality phenotype intersection_of: exists_during GO:0060274 ! maintenance of stationary phase intersection_of: has_part FYPO:0002787 ! small vacuoles intersection_of: has_part FYPO:0002790 ! vacuoles present in greater numbers relationship: exists_during GO:0060274 ! maintenance of stationary phase relationship: has_part FYPO:0002787 ! small vacuoles relationship: has_part FYPO:0002790 ! vacuoles present in greater numbers created_by: midori creation_date: 2013-10-16T15:41:48Z [Term] id: FYPO:0002792 name: small vacuoles present in greater numbers during cellular hypotonic response def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell contains more, but smaller, vacuoles than normal during a cellular response to a hypotonic environment." [PomBase:mah] synonym: "fragmented vacuoles during cellular hypotonic response" RELATED [PomBase:mah] synonym: "small vacuoles present in greater numbers during cellular hypotonic response during mitotic cell cycle" RELATED [PomBase:mah] synonym: "small vacuoles present in greater numbers during cellular hypotonic response during vegetative growth" EXACT [PomBase:mah] synonym: "small vacuoles present in greater numbers during hypotonic stress" EXACT [PomBase:al] is_a: FYPO:0002258 ! small vacuoles present in greater numbers intersection_of: FYPO:0004638 ! abnormal cellular physical quality phenotype intersection_of: exists_during GO:0071476 ! cellular hypotonic response intersection_of: has_part FYPO:0002787 ! small vacuoles intersection_of: has_part FYPO:0002790 ! vacuoles present in greater numbers relationship: exists_during GO:0071476 ! cellular hypotonic response relationship: has_part FYPO:0002787 ! small vacuoles relationship: has_part FYPO:0002790 ! vacuoles present in greater numbers created_by: midori creation_date: 2013-10-16T15:44:28Z [Term] id: FYPO:0002793 name: vacuoles present in decreased numbers during vegetative growth def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells contain fewer vacuoles than normal." [PomBase:mah] synonym: "decreased level of vacuoles during vegetative growth" RELATED [PomBase:al] synonym: "fewer vacuoles present during vegetative growth" EXACT [PomBase:mah] synonym: "vacuoles present in decreased numbers during mitotic cell cycle" RELATED [PomBase:mah] synonym: "vacuoles present in reduced numbers during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0004639 ! abnormal cellular physical quality phenotype during vegetative growth is_a: PATO:0002001 ! has fewer parts of type intersection_of: PATO:0002001 ! has fewer parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0000324 ! fungal-type vacuole relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0000324 ! fungal-type vacuole created_by: midori creation_date: 2013-10-16T15:53:47Z [Term] id: FYPO:0002794 name: abnormal vacuole def: "A physical cellular phenotype in which the number, distribution, or morphology of all or part of the vacuole(s) is abnormal." [PomBase:mah] comment: Note that an abnormal cytoskeleton organization process may, but does not necessarily, result in a physically abnormal cytoskeleton. synonym: "abnormal vacuole physical object quality" EXACT [PomBase:mah] synonym: "abnormal vacuoles" EXACT [PomBase:mah] is_a: FYPO:0004638 ! abnormal cellular physical quality phenotype intersection_of: PATO:0001241 ! physical object quality intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-10-16T15:54:06Z [Term] id: FYPO:0002795 name: large vacuoles present in decreased numbers during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell contains fewer, but larger, vacuoles than normal." [PomBase:mah] synonym: "enlarged vacuoles present in decreased numbers during vegetative growth" EXACT [PomBase:mah] synonym: "large vacuoles present in decreased numbers during mitotic cell cycle" RELATED [PomBase:mah] synonym: "large vacuoles present in reduced numbers during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0004638 ! abnormal cellular physical quality phenotype intersection_of: FYPO:0004638 ! abnormal cellular physical quality phenotype intersection_of: has_part FYPO:0000123 ! large vacuoles during vegetative growth intersection_of: has_part FYPO:0002793 ! vacuoles present in decreased numbers during vegetative growth relationship: has_part FYPO:0000123 ! large vacuoles during vegetative growth relationship: has_part FYPO:0002793 ! vacuoles present in decreased numbers during vegetative growth created_by: midori creation_date: 2013-10-16T16:02:59Z [Term] id: FYPO:0002796 name: abnormal protein degradation during nitrogen starvation def: "A cellular process phenotype in which protein degradation is abnormal when the cell is subject to nitrogen starvation. Protein degradation, also known as protein catabolism, is any metabolic process that results in the destruction of the native, active configuration of a protein, with or without the hydrolysis of peptide bonds." [GO:0030163, PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein breakdown during nitrogen starvation" EXACT [GO:0030163, PomBase:mah] synonym: "abnormal protein catabolic process during nitrogen starvation" EXACT [GO:0030163, PomBase:mah] synonym: "abnormal protein catabolism during nitrogen starvation" EXACT [GO:0030163, PomBase:mah] synonym: "abnormal protein degradation during nitrogen depletion" EXACT [PomBase:vw] synonym: "abnormal protein degradation during nitrogen deprivation" EXACT [PomBase:vw] is_a: FYPO:0002275 ! abnormal protein degradation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in_part_of GO:0030163 ! protein catabolic process intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in_part_of GO:0030163 ! protein catabolic process relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-10-16T16:11:43Z [Term] id: FYPO:0002797 name: decreased protein degradation def: "A cellular process phenotype in which the occurrence of protein degradation is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein breakdown" EXACT [GO:0030163, PomBase:mah] synonym: "decreased protein catabolic process" EXACT [GO:0030163, PomBase:mah] synonym: "decreased protein catabolism" EXACT [GO:0030163, PomBase:mah] synonym: "reduced protein degradation" EXACT [PomBase:mah] is_a: FYPO:0002275 ! abnormal protein degradation is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0030163 ! protein catabolic process relationship: has_output FYPO:0000836 ! increased protein level relationship: inheres_in GO:0030163 ! protein catabolic process created_by: midori creation_date: 2013-10-16T16:12:20Z [Term] id: FYPO:0002798 name: decreased protein degradation during nitrogen starvation def: "A cellular process phenotype in which the occurrence of protein degradation is decreased when the cell is subject to nitrogen starvation." [PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein catabolic process during nitrogen starvation" EXACT [GO:0030163, PomBase:mah] synonym: "decreased protein catabolism during nitrogen starvation" EXACT [GO:0030163, PomBase:mah] synonym: "decreased protein degradation during nitrogen depletion" EXACT [PomBase:vw] synonym: "decreased protein degradation during nitrogen deprivation" EXACT [PomBase:vw] synonym: "reduced protein degradation during nitrogen starvation" EXACT [PomBase:mah] is_a: FYPO:0002796 ! abnormal protein degradation during nitrogen starvation is_a: FYPO:0002797 ! decreased protein degradation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in GO:0030163 ! protein catabolic process relationship: happens_during GO:0006995 ! cellular response to nitrogen starvation relationship: has_output FYPO:0001219 ! increased protein level during cellular response to nitrogen starvation relationship: inheres_in GO:0030163 ! protein catabolic process created_by: midori creation_date: 2013-10-16T16:12:34Z [Term] id: FYPO:0002799 name: normal protein degradation def: "A cellular process phenotype in which protein degradation is normal (i.e. indistinguishable from wild type). Protein degradation, also known as protein catabolism, is any metabolic process that results in the destruction of the native, active configuration of a protein, with or without the hydrolysis of peptide bonds." [GO:0030163, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein breakdown" EXACT [GO:0030163, PomBase:mah] synonym: "normal protein catabolic process" EXACT [GO:0030163, PomBase:mah] synonym: "normal protein catabolism" EXACT [GO:0030163, PomBase:mah] is_a: FYPO:0000627 ! normal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0030163 ! protein catabolic process intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0030163 ! protein catabolic process relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-10-16T16:17:41Z [Term] id: FYPO:0002800 name: normal protein degradation during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which protein degradation is normal (i.e. indistinguishable from wild type). Protein degradation, also known as protein catabolism, is any metabolic process that results in the destruction of the native, active configuration of a protein, with or without the hydrolysis of peptide bonds." [GO:0030163, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein breakdown during vegetative growth" EXACT [GO:0030163, PomBase:mah] synonym: "normal protein catabolic process during vegetative growth" EXACT [GO:0030163, PomBase:mah] synonym: "normal protein catabolism during vegetative growth" EXACT [GO:0030163, PomBase:mah] synonym: "normal protein degradation during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001319 ! normal cellular process during vegetative growth is_a: FYPO:0002799 ! normal protein degradation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0030163 ! protein catabolic process intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0030163 ! protein catabolic process relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-10-16T16:23:50Z [Term] id: FYPO:0002801 name: normal protein degradation during nitrogen starvation def: "A cellular process phenotype in which protein degradation is normal (i.e. indistinguishable from wild type) when the cell is subject to nitrogen starvation. Protein degradation, also known as protein catabolism, is any metabolic process that results in the destruction of the native, active configuration of a protein, with or without the hydrolysis of peptide bonds." [GO:0030163, PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein breakdown during nitrogen starvation" EXACT [GO:0030163, PomBase:mah] synonym: "normal protein catabolic process during nitrogen starvation" EXACT [GO:0030163, PomBase:mah] synonym: "normal protein catabolism during nitrogen starvation" EXACT [GO:0030163, PomBase:mah] synonym: "normal protein degradation during nitrogen depletion" EXACT [PomBase:vw] synonym: "normal protein degradation during nitrogen deprivation" EXACT [PomBase:vw] is_a: FYPO:0002799 ! normal protein degradation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in GO:0030163 ! protein catabolic process intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in GO:0030163 ! protein catabolic process relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-10-16T16:24:11Z [Term] id: FYPO:0002802 name: nucleus mislocalized to cell cortex during nitrogen starvation def: "A physical cellular phenotype in which a cell has a nucleus in an abnormal location at the cell cortex when the cell is subject to nitrogen starvation. The normal location is at the midpoint of the long axis of the cell." [PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "nucleus mislocalised to cell cortex during nitrogen starvation" EXACT [PomBase:mah] synonym: "nucleus mislocalized to cell cortex during nitrogen depletion" EXACT [PomBase:vw] synonym: "nucleus mislocalized to cell cortex during nitrogen deprivation" EXACT [PomBase:vw] is_a: FYPO:0002069 ! mislocalized nucleus created_by: midori creation_date: 2013-10-16T16:33:25Z [Term] id: FYPO:0002803 name: abnormal vacuole organization def: "A cellular process phenotype in which vacuole organization is abnormal. Vacuole organization results in the assembly, arrangement of constituent parts, or disassembly of a vacuole." [GO:0007033, PomBase:mah] comment: Consider annotating to 'abnormal vacuolar morphology' (FYPO:0002257), but note that an abnormal vacuole organization process may, but does not necessarily, result in abnormal vacuolar morphology. synonym: "abnormal vacuolar organisation" EXACT [PomBase:vw] synonym: "abnormal vacuolar organization" EXACT [PomBase:vw] synonym: "abnormal vacuole organisation" EXACT [PomBase:mah] is_a: FYPO:0000335 ! abnormal cellular component organization intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0007033 ! vacuole organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0007033 ! vacuole organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-10-16T16:35:40Z [Term] id: FYPO:0002804 name: abnormal vacuole organization during nitrogen starvation def: "A cellular process phenotype in which vacuole organization is abnormal when the cell is subject to nitrogen starvation. Vacuole organization results in the assembly, arrangement of constituent parts, or disassembly of a vacuole." [GO:0007033, PomBase:mah] comment: Consider annotating to 'abnormal vacuolar morphology' (FYPO:0002257), but note that an abnormal vacuole organization process may, but does not necessarily, result in abnormal vacuolar morphology. This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "abnormal vacuolar organisation during nitrogen starvation" EXACT [PomBase:vw] synonym: "abnormal vacuolar organization during nitrogen starvation" EXACT [PomBase:vw] synonym: "abnormal vacuole organisation during nitrogen starvation" EXACT [PomBase:mah] synonym: "abnormal vacuole organization during nitrogen depletion" EXACT [PomBase:vw] synonym: "abnormal vacuole organization during nitrogen deprivation" EXACT [PomBase:vw] is_a: FYPO:0002803 ! abnormal vacuole organization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in_part_of GO:0007033 ! vacuole organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in_part_of GO:0007033 ! vacuole organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-10-16T16:37:13Z [Term] id: FYPO:0002805 name: normal sodium import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which sodium ion import into the cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal adenine uptake" EXACT [PomBase:mah] synonym: "normal sodium import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal sodium import during vegetative growth" EXACT [PomBase:mah] synonym: "normal sodium import into cell" EXACT [PomBase:al] synonym: "normal sodium ion import into cell" EXACT [PomBase:mah] is_a: FYPO:0001071 ! normal transport is_a: FYPO:0001336 ! transport phenotype during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990118 ! sodium ion import into cell intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990118 ! sodium ion import into cell relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-10-22T14:47:17Z [Term] id: FYPO:0002806 name: sensitive to arsenate def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to arsenate ions. Cells stop growing (and may die) at a concentration of arsenate that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to arsenate" EXACT [PomBase:mah] synonym: "sensitive to arsenate during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to arsenate during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to arsenate ions" EXACT [PomBase:mah] is_a: FYPO:0000093 ! sensitive to arsenic intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:22629 ! arsenate ion relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:22629 ! arsenate ion created_by: midori creation_date: 2013-10-22T14:58:17Z [Term] id: FYPO:0002807 name: normal growth on arsenate def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing arsenate ions." [PomBase:mah] synonym: "normal cell population growth in presence of arsenate" EXACT [PomBase:mah] synonym: "normal cell population growth on arsenate" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cell population growth on arsenate ion" EXACT [PomBase:mah] synonym: "normal cellular response to arsenate" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on arsenate" EXACT [PomBase:mah] is_a: FYPO:0004368 ! normal growth on arsenic intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:22629 ! arsenate ion relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:22629 ! arsenate ion created_by: midori creation_date: 2013-10-22T15:00:18Z [Term] id: FYPO:0002808 name: abnormal 6,7-dimethyl-8-ribityllumazine synthase activity def: "A molecular function phenotype in which the observed rate of 6,7-dimethyl-8-ribityllumazine synthase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0000906 ! 6,7-dimethyl-8-ribityllumazine synthase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0000906 ! 6,7-dimethyl-8-ribityllumazine synthase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-10-22T15:09:52Z [Term] id: FYPO:0002809 name: decreased 6,7-dimethyl-8-ribityllumazine synthase activity def: "A molecular function phenotype in which the observed rate of 6,7-dimethyl-8-ribityllumazine synthase activity is decreased." [PomBase:mah] synonym: "reduced 6,7-dimethyl-8-ribityllumazine synthase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0002808 ! abnormal 6,7-dimethyl-8-ribityllumazine synthase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0000906 ! 6,7-dimethyl-8-ribityllumazine synthase activity relationship: inheres_in GO:0000906 ! 6,7-dimethyl-8-ribityllumazine synthase activity created_by: midori creation_date: 2013-10-22T15:09:58Z [Term] id: FYPO:0002810 name: normal septation index in stationary phase def: "A cell population phenotype in which the septation index is normal (i.e. indistinguishable from wild type) in a population in stationary phase. The septation index is the proportion of the population undergoing septation at any given time." [PomBase:mah, PomBase:vw] synonym: "normal septation in stationary phase" RELATED [PomBase:mah] synonym: "normal septation index during stationary phase" EXACT [PomBase:mah] is_a: FYPO:0001903 ! normal septation index created_by: midori creation_date: 2013-10-22T15:24:17Z [Term] id: FYPO:0002811 name: sensitive to non-ionic osmotic stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to a non-ionic osmotic stress." [PomBase:mah] synonym: "hypersensitive to non-ionic osmotic stress" EXACT [PomBase:mah] synonym: "sensitive to non-ionic osmotic stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to non-ionic osmotic stress during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000270 ! sensitive to osmotic stress created_by: midori creation_date: 2013-10-22T15:47:09Z [Term] id: FYPO:0002812 name: decreased cellular glycerol level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of glycerol measured in a cell is lower than normal." [PomBase:mah] synonym: "decreased cellular glycerol level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular glycerol level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased glycerol accumulation" RELATED [PomBase:al] synonym: "reduced cellular glycerol level" EXACT [PomBase:mah] is_a: FYPO:0001329 ! decreased level of substance in cell during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:17754 ! glycerol relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:17754 ! glycerol created_by: midori creation_date: 2013-10-22T16:05:42Z [Term] id: FYPO:0002813 name: decreased cellular glycerol level during cellular response to salt stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of glycerol measured in a cell during a cellular response to salt stress is lower than normal." [PomBase:mah] synonym: "decreased cellular glycerol level during cellular response to salt stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular glycerol level during cellular response to salt stress during vegetative growth" EXACT [PomBase:mah] synonym: "decreased glycerol accumulation during cellular response to salt stress" RELATED [PomBase:al] synonym: "reduced cellular glycerol level during cellular response to salt stress" EXACT [PomBase:mah] is_a: FYPO:0002812 ! decreased cellular glycerol level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0071472 ! cellular response to salt stress intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:17754 ! glycerol relationship: exists_during GO:0071472 ! cellular response to salt stress relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:17754 ! glycerol created_by: midori creation_date: 2013-10-22T16:06:13Z [Term] id: FYPO:0002814 name: abnormal protein localization to cell surface def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the cell surface is abnormal. The cell surface refers to the external part of the cell wall and/or plasma membrane." [PomBase:mah] comment: Encompasses both presence of proteins not normally found at the cell surface and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to cell surface" EXACT [PomBase:mah] synonym: "abnormal protein localization to cell surface during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein localization to cell surface during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000443 ! abnormal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0034394 ! protein localization to cell surface intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0034394 ! protein localization to cell surface relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-10-22T16:10:52Z [Term] id: FYPO:0002815 name: abolished protein localization to cell surface def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the cell surface is abolished. The cell surface refers to the external part of the cell wall and/or plasma membrane." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to cell surface" EXACT [PomBase:mah] synonym: "abolished protein localization to cell surface during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to cell surface during vegetative growth" EXACT [PomBase:mah] synonym: "protein localization to cell surface abolished" EXACT [PomBase:mah] is_a: FYPO:0001179 ! protein localization abolished during vegetative growth is_a: FYPO:0002814 ! abnormal protein localization to cell surface intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0034394 ! protein localization to cell surface relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0034394 ! protein localization to cell surface created_by: midori creation_date: 2013-10-22T16:11:09Z [Term] id: FYPO:0002816 name: inviable after spore germination, without cell division, multinucleate cell with elongated germ tube def: "A phenotype in which a spore germinates to produce an elongated germ tube, and in which the nucleus divides at least once to produce a multinucleate cell. The cell does not divide, and eventually dies." [PomBase:mah] synonym: "essential; germinating spore without cell division, multinucleate cell with elongated germ tube" RELATED [PomBase:mah] synonym: "inviable after spore germination, without cell division, elongated multinucleate cell" EXACT [PomBase:mah] synonym: "inviable germinated spore, without cell division, multinucleate cell with elongated germ tube" EXACT [PomBase:mah] synonym: "inviable multinucleate germinated spore with elongated germ tube" EXACT [PomBase:mah] synonym: "multinucleate after spore germination with elongated germ tube" EXACT [PomBase:vw] is_a: FYPO:0002379 ! inviable after spore germination, without cell division, with elongated germ tube created_by: midori creation_date: 2013-10-29T12:17:06Z [Term] id: FYPO:0002817 name: abnormally arrested meiosis I def: "A cellular process phenotype in which the first meiotic nuclear division is arrested under conditions where arrest does not normally occur." [PomBase:mah] synonym: "cell cycle arrest in meiosis I" EXACT [PomBase:mah] is_a: FYPO:0000475 ! abnormally arrested meiosis intersection_of: PATO:0001561 ! having extra processual parts intersection_of: during GO:0007126 ! meiotic nuclear division intersection_of: inheres_in GO:0007127 ! meiosis I relationship: during GO:0007126 ! meiotic nuclear division relationship: inheres_in GO:0007127 ! meiosis I created_by: midori creation_date: 2013-10-29T12:52:39Z [Term] id: FYPO:0002818 name: microtubule bundles present in decreased numbers def: "A physical cellular phenotype in which cells contain fewer microtubule bundles than normal." [PomBase:mah] synonym: "decreased level of MT bundles" EXACT [PomBase:mah] synonym: "decreased microtubule bundling" RELATED [PomBase:vw] synonym: "microtubule bundles present in reduced numbers" EXACT [PomBase:mah] is_a: FYPO:0004315 ! abnormal microtubule cytoskeleton during vegetative growth is_a: PATO:0002001 ! has fewer parts of type intersection_of: PATO:0002001 ! has fewer parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0097427 ! microtubule bundle relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0097427 ! microtubule bundle created_by: midori creation_date: 2013-11-04T12:25:29Z [Term] id: FYPO:0002819 name: increased histone H3-K9 acetylation at telomere def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which acetylation of lysine at position 9 of histone H3 in telomeric regions occurs to a greater extent than normal." [PomBase:mah] synonym: "increased histone H3-K9 acetylation at telomere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H3-K9 acetylation at telomere during vegetative growth" EXACT [PomBase:mah] synonym: "increased histone H3-K9 acetylation at telomeric region" EXACT [PomBase:vw] synonym: "increased histone H3K9 acetylation at telomere" EXACT [GO:0043970, PomBase:mah] synonym: "increased telomeric histone H3K9 acetylation" EXACT [GO:0043970, PomBase:mah] is_a: FYPO:0000892 ! increased histone H3-K9 acetylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0043970 ! histone H3-K9 acetylation intersection_of: occurs_at SO:0000624 ! telomere relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0043970 ! histone H3-K9 acetylation relationship: occurs_at SO:0000624 ! telomere created_by: midori creation_date: 2013-11-04T12:36:50Z [Term] id: FYPO:0002820 name: abolished histone H3-K9 methylation at telomere def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which methylation of lysine at position 9 of histone H3 in telomeric regions does not occur." [PomBase:mah] synonym: "abolished histone H3 K9 methylation at telomere" EXACT [GO:0051567, PomBase:mah] synonym: "abolished histone H3-K9 methylation at telomere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished histone H3-K9 methylation at telomere during vegetative growth" EXACT [PomBase:mah] synonym: "abolished histone H3-K9 methylation at telomeric region" EXACT [PomBase:vw] synonym: "abolished histone H3K9me at telomere" EXACT [GO:0051567, PomBase:mah] synonym: "abolished histone lysine H3 K9 methylation at telomere" EXACT [GO:0051567, PomBase:mah] synonym: "abolished telomeric histone H3-K9 methylation" EXACT [PomBase:mah] synonym: "histone H3-K9 methylation abolished at telomere" EXACT [PomBase:mah] synonym: "histone H3-K9 methylation absent at telomere" EXACT [PomBase:al] is_a: FYPO:0002566 ! abolished histone H3-K9 methylation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: occurs_at SO:0000624 ! telomere intersection_of: towards GO:0051567 ! histone H3-K9 methylation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: occurs_at SO:0000624 ! telomere relationship: towards GO:0051567 ! histone H3-K9 methylation created_by: midori creation_date: 2013-11-04T12:47:19Z [Term] id: FYPO:0002821 name: decreased protein localization to mitotic spindle pole body during interphase def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the mitotic spindle pole body is decreased during interphase." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to mitotic spindle pole body during interphase" EXACT [PomBase:mah] synonym: "decreased protein localization to mitotic SPB during interphase" EXACT [PomBase:mah] synonym: "decreased protein localization to mitotic spindle pole body during mitotic interphase" EXACT [PomBase:mah] synonym: "decreased protein localization to spindle pole body during interphase during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to mitotic spindle pole body during interphase" EXACT [PomBase:mah] is_a: FYPO:0000940 ! decreased protein localization to mitotic spindle pole body intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0051329 ! mitotic interphase intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902440 ! protein localization to mitotic spindle pole body relationship: happens_during GO:0051329 ! mitotic interphase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902440 ! protein localization to mitotic spindle pole body created_by: midori creation_date: 2013-11-04T13:11:14Z [Term] id: FYPO:0002822 name: decreased protein localization to mitotic spindle pole body during mitosis def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the mitotic spindle pole body is decreased during mitosis." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to mitotic spindle pole body during mitosis" EXACT [PomBase:mah] synonym: "decreased protein localization to mitotic SPB during mitosis" EXACT [PomBase:mah] synonym: "decreased protein localization to mitotic spindle pole body during M-phase" RELATED [PomBase:vw] synonym: "decreased protein localization to mitotic spindle pole body during mitotic M phase" RELATED [PomBase:mah] synonym: "decreased protein localization to mitotic spindle pole body during mitotic nuclear division" EXACT [GO:0007067] synonym: "decreased protein localization to spindle pole body during mitosis during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to mitotic spindle pole body during mitosis" EXACT [PomBase:mah] is_a: FYPO:0000940 ! decreased protein localization to mitotic spindle pole body intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0007067 ! mitotic nuclear division intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902440 ! protein localization to mitotic spindle pole body relationship: happens_during GO:0007067 ! mitotic nuclear division relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902440 ! protein localization to mitotic spindle pole body created_by: midori creation_date: 2013-11-04T13:12:56Z [Term] id: FYPO:0002823 name: abolished protein localization to mitotic spindle pole body during interphase def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the mitotic spindle pole body does not occur during interphase." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "protein absent from mitotic spindle pole body during interphase" RELATED [PomBase:mah] synonym: "protein localisation to mitotic spindle pole body abolished during interphase" EXACT [PomBase:mah] synonym: "protein localization to mitotic SPB abolished during interphase" EXACT [PomBase:mah] synonym: "protein localization to mitotic spindle pole body abolished during interphase" EXACT [PomBase:mah] synonym: "protein localization to spindle pole body abolished during interphase during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000941 ! abolished protein localization to mitotic spindle pole body intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0051329 ! mitotic interphase intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1902440 ! protein localization to mitotic spindle pole body relationship: during GO:0051329 ! mitotic interphase relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1902440 ! protein localization to mitotic spindle pole body created_by: midori creation_date: 2013-11-04T13:14:32Z [Term] id: FYPO:0002824 name: abnormal protein localization to mitotic spindle def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the mitotic spindle is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found at the spindle and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to mitotic spindle" EXACT [PomBase:mah] synonym: "abnormal protein localization to spindle during mitosis" EXACT [PomBase:mah] synonym: "abnormal protein localization to spindle during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000931 ! abnormal protein localization to microtubule cytoskeleton during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1902480 ! protein localization to mitotic spindle intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1902480 ! protein localization to mitotic spindle relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-11-04T13:17:20Z [Term] id: FYPO:0002825 name: decreased protein localization to mitotic spindle def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the mitotic spindle is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to mitotic spindle" EXACT [PomBase:mah] synonym: "decreased protein localization to spindle during mitosis" EXACT [PomBase:mah] synonym: "decreased protein localization to spindle during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to mitotic spindle" EXACT [PomBase:mah] is_a: FYPO:0000933 ! decreased protein localization to microtubule cytoskeleton during vegetative growth is_a: FYPO:0002824 ! abnormal protein localization to mitotic spindle intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902480 ! protein localization to mitotic spindle relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902480 ! protein localization to mitotic spindle created_by: midori creation_date: 2013-11-04T13:17:33Z [Term] id: FYPO:0002826 name: normal gamma-tubulin complex assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which gamma-tubulin complex assembly is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal gamma-tubulin complex assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal gamma-tubulin complex assembly during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001215 ! normal protein complex assembly intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902481 ! gamma-tubulin complex assembly intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902481 ! gamma-tubulin complex assembly relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-11-04T13:25:12Z [Term] id: FYPO:0002827 name: decreased chromatin silencing at silent mating-type cassette def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of chromatin silencing at the silent mating-type cassettes is decreased." [PomBase:mah] synonym: "decreased chromatin silencing at silent mating-type cassette during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased chromatin silencing at silent mating-type cassette during vegetative growth" EXACT [PomBase:mah] synonym: "reduced chromatin silencing at silent mating-type cassette" EXACT [PomBase:mah] is_a: FYPO:0002353 ! decreased chromatin silencing intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0030466 ! chromatin silencing at silent mating-type cassette relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0030466 ! chromatin silencing at silent mating-type cassette created_by: midori creation_date: 2013-11-04T14:46:08Z [Term] id: FYPO:0002828 name: constitutive protein kinase activity def: "A regulation phenotype in which the basal activity of a protein kinase is increased relative to normal. Basal protein kinase activity is the activity observed in the absence of a regulator. Abnormally elevated basal activity may or may not reach the levels observed in the normal activated state." [PomBase:al, PomBase:mah] synonym: "constitutive protein kinase activity during mitotic cell cycle" RELATED [PomBase:mah] synonym: "constitutive protein kinase activity during vegetative growth" EXACT [PomBase:mah] synonym: "constitutively active protein kinase" RELATED [PomBase:mah] is_a: FYPO:0000683 ! constitutive catalytic activity created_by: midori creation_date: 2013-11-04T14:49:21Z [Term] id: FYPO:0002829 name: decreased cellular phytochelatin level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of phytochelatin measured in a cell is lower than normal." [PomBase:mah] synonym: "decreased cellular cadystin level" EXACT [PomBase:mah] synonym: "decreased cellular phytochelatin level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular phytochelatin level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased phytochelatin accumulation" RELATED [PomBase:al] synonym: "reduced cellular phytochelatin level" EXACT [PomBase:mah] is_a: FYPO:0001329 ! decreased level of substance in cell during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:60836 ! phytochelatin relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:60836 ! phytochelatin created_by: midori creation_date: 2013-11-04T15:38:55Z [Term] id: FYPO:0002830 name: delayed protein phosphorylation during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, begins later than normal." [PomBase:mah] synonym: "delayed protein phosphorylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "delayed protein/peptide phosphorylation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000546 ! delayed protein modification is_a: FYPO:0000775 ! abnormal protein phosphorylation during vegetative growth intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2013-11-04T15:41:33Z [Term] id: FYPO:0002831 name: delayed protein phosphorylation during mitotic M phase def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, begins later than normal during M phase of the mitotic cell cycle." [PomBase:mah] synonym: "delayed protein phosphorylation during mitotic M phase during vegetative growth" EXACT [PomBase:mah] synonym: "delayed protein phosphorylation during mitotic M-phase" EXACT [PomBase:vw] synonym: "delayed protein/peptide phosphorylation during mitotic M phase" EXACT [PomBase:mah] is_a: FYPO:0002830 ! delayed protein phosphorylation during vegetative growth intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0000087 ! mitotic M phase intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0000087 ! mitotic M phase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2013-11-04T15:43:06Z [Term] id: FYPO:0002832 name: decreased protein phosphorylation during mitotic M phase def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal during M phase of the mitotic cell cycle." [PomBase:mah] synonym: "decreased protein phosphorylation during mitotic M phase during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein phosphorylation during mitotic M-phase" EXACT [PomBase:vw] synonym: "decreased protein/peptide phosphorylation during mitotic M phase" EXACT [PomBase:mah] synonym: "reduced protein phosphorylation during mitotic M phase" EXACT [PomBase:mah] is_a: FYPO:0001838 ! decreased protein phosphorylation during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0000087 ! mitotic M phase intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0000087 ! mitotic M phase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2013-11-04T15:49:37Z [Term] id: FYPO:0002833 name: decreased polyuridylation-dependent decapping of nuclear-transcribed mRNA def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of polyuridylation-dependent decapping of nuclear-transcribed mRNA is decreased. All RNA decapping may be decreased, or one or more specific RNA molecules may be selectively affected." [PomBase:mah] synonym: "decreased poly(U)-dependent decapping of nuclear-transcribed mRNA" EXACT [PomBase:vw] synonym: "decreased polyuridylation-dependent decapping of nuclear-transcribed mRNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased polyuridylation-dependent decapping of nuclear-transcribed mRNA during vegetative growth" EXACT [PomBase:mah] synonym: "decreased uridylation-dependent decapping of nuclear-transcribed mRNA" BROAD [GO:0036450] synonym: "reduced polyuridylation-dependent decapping of nuclear-transcribed mRNA" EXACT [PomBase:mah] is_a: FYPO:0002039 ! decreased deadenylation-independent decapping of nuclear-transcribed mRNA intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0036450 ! polyuridylation-dependent decapping of nuclear-transcribed mRNA relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0036450 ! polyuridylation-dependent decapping of nuclear-transcribed mRNA created_by: midori creation_date: 2013-11-04T15:52:41Z [Term] id: FYPO:0002834 name: decreased chromatin silencing at centromere def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of chromatin silencing at centromeric regions is decreased." [PomBase:mah] synonym: "decreased chromatin silencing at centromere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased chromatin silencing at centromere during vegetative growth" EXACT [PomBase:mah] synonym: "decreased heterochromatin silencing at centromere" RELATED [PomBase:mah] synonym: "reduced chromatin silencing at centromere" EXACT [PomBase:mah] is_a: FYPO:0002353 ! decreased chromatin silencing intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0030702 ! chromatin silencing at centromere relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0030702 ! chromatin silencing at centromere created_by: midori creation_date: 2013-11-05T14:24:37Z [Term] id: FYPO:0002835 name: centromeric outer repeat transcript-derived siRNA absent def: "An RNA metabolism phenotype observed in the vegetative growth phase of the life cycle in which small interfering RNA transcripts derived from the centromere outer repeat region are absent." [PMID:20211136, PomBase:mah] comment: This term refers specifically to siRNAs derived by dicer-mediated processing of RNA from the centromere outer repeat region. Use this term only for levels of RNA transcribed from endogenous centromere outer repeat sequences. For levels of RNA transcribed from an exogenous reporter gene placed in the outer repeat region, consider 'abnormal chromatin silencing at centromere outer repeat region' (FYPO:0002346). synonym: "centromere outer repeat transcript-derived siRNA absent" EXACT [PomBase:mah] synonym: "centromeric outer repeat transcript-derived siRNA undetectable" EXACT [PomBase:mah] synonym: "siRNAs homologous to outer repeats absent" EXACT [PomBase:vw] synonym: "siRNAs homologous to outer repeats undetectable" EXACT [PomBase:mah] is_a: FYPO:0000273 ! centromeric outer repeat transcripts absent is_a: FYPO:0004201 ! decreased centromeric outer repeat transcript-derived siRNA level created_by: midori creation_date: 2013-11-05T14:44:13Z [Term] id: FYPO:0002836 name: increased centromeric outer repeat transcript-derived siRNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which small interfering RNA transcripts derived from the centromere outer repeat region are present at greater levels than normal." [PMID:20211136, PomBase:mah] comment: This term refers specifically to siRNAs derived by dicer-mediated processing of RNA from the centromere outer repeat region. Use this term only for levels of RNA transcribed from endogenous centromere outer repeat sequences. For levels of RNA transcribed from an exogenous reporter gene placed in the outer repeat region, consider 'decreased chromatin silencing at centromere outer repeat region' (FYPO:0003412). synonym: "increased accumulation of centromeric outer repeat transcript-derived siRNA" EXACT [PomBase:mah] synonym: "increased accumulation of siRNAs homologous to outer repeats" RELATED [PomBase:vw] synonym: "increased centromere outer repeat transcript-derived siRNA level" EXACT [PomBase:mah] synonym: "increased centromeric outer repeat transcript-derived siRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased centromeric outer repeat transcript-derived siRNA level during vegetative growth" EXACT [PomBase:mah] synonym: "increased level of centromeric outer repeat transcript-derived siRNA" EXACT [PomBase:mah] synonym: "increased level of siRNAs homologous to outer repeats" EXACT [PomBase:vw] is_a: FYPO:0000220 ! increased centromeric outer repeat transcript level is_a: FYPO:0004207 ! increased siRNA level created_by: midori creation_date: 2013-11-05T14:46:21Z [Term] id: FYPO:0002837 name: normal centromeric outer repeat transcript-derived siRNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of small interfering RNA transcripts derived from the centromere outer repeat region measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: This term refers specifically to siRNAs derived by dicer-mediated processing of RNA from the centromere outer repeat region. Use this term only for levels of RNA transcribed from endogenous centromere outer repeat sequences. synonym: "normal accumulation of centromeric outer repeat transcript-derived siRNA" RELATED [PomBase:mah] synonym: "normal accumulation of centromeric outer repeat transcript-derived siRNA during vegetative growth" RELATED [PomBase:mah] synonym: "normal accumulation of siRNAs homologous to outer repeats" RELATED [PomBase:vw] synonym: "normal centromeric outer repeat transcript-derived siRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal centromeric outer repeat transcript-derived siRNA level during vegetative growth" EXACT [PomBase:mah] synonym: "normal level of siRNAs homologous to outer repeats" EXACT [PomBase:vw] is_a: FYPO:0002567 ! normal centromeric outer repeat transcript level created_by: midori creation_date: 2013-11-05T14:49:58Z [Term] id: FYPO:0002838 name: abnormal protein localization to chromosome def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to a specific location on a chromosome is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found at the centromere and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to chromosome" EXACT [PomBase:mah] synonym: "abnormal protein localization to chromosome during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein localization to chromosome during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000443 ! abnormal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0034502 ! protein localization to chromosome intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0034502 ! protein localization to chromosome relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-11-05T15:32:17Z [Term] id: FYPO:0002839 name: decreased protein localization to chromosome def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to a specific location on a chromosome is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to chromosome" EXACT [PomBase:mah] synonym: "decreased protein localization to chromosome during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to chromosome during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to chromosome" EXACT [PomBase:mah] is_a: FYPO:0002838 ! abnormal protein localization to chromosome is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034502 ! protein localization to chromosome relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034502 ! protein localization to chromosome created_by: midori creation_date: 2013-11-05T15:33:34Z [Term] id: FYPO:0002840 name: increased protein localization to chromosome def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to a specific location on a chromosome is increased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to chromosome" EXACT [PomBase:mah] synonym: "increased protein localization to chromosome during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein localization to chromosome during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002838 ! abnormal protein localization to chromosome is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034502 ! protein localization to chromosome relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034502 ! protein localization to chromosome created_by: midori creation_date: 2013-11-05T15:33:43Z [Term] id: FYPO:0002841 name: abolished protein localization to chromosome def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to a specific location on a chromosome is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to chromosome" EXACT [PomBase:mah] synonym: "abolished protein localization to chromosome during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to chromosome during vegetative growth" EXACT [PomBase:mah] synonym: "protein localization to chromosome abolished" EXACT [PomBase:mah] is_a: FYPO:0001179 ! protein localization abolished during vegetative growth is_a: FYPO:0002838 ! abnormal protein localization to chromosome intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0034502 ! protein localization to chromosome relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0034502 ! protein localization to chromosome created_by: midori creation_date: 2013-11-05T15:33:50Z [Term] id: FYPO:0002842 name: decreased protein localization to centromere outer repeat def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the centromere outer repeat regions of a chromosome is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to centromere outer repeat" EXACT [PomBase:mah] synonym: "decreased protein localisation to centromeric outer repeat region" EXACT [GO:0071459, PomBase:mah] synonym: "decreased protein localization to centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to centromere outer repeat during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein localization to chromosome, centric outer repeat region" EXACT [GO:0071459, PomBase:mah] synonym: "decreased protein localization to chromosome, centromeric outer repeat region" EXACT [GO:0071459, PomBase:mah] synonym: "decreased protein localization to pericentric region" RELATED [PomBase:mah] synonym: "decreased protein localization to pericentromeric region" RELATED [PomBase:mah] synonym: "reduced protein localization to centromere outer repeat" EXACT [PomBase:mah] is_a: FYPO:0000449 ! abnormal protein localization to centromere is_a: FYPO:0002839 ! decreased protein localization to chromosome intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034502 ! protein localization to chromosome intersection_of: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034502 ! protein localization to chromosome relationship: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region created_by: midori creation_date: 2013-11-05T15:39:52Z [Term] id: FYPO:0002843 name: protein mislocalized to nucleoplasm def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a protein that is not normally found in the nucleoplasm is observed there." [PomBase:mah] comment: Note that this term can be used to annotate any case where a protein is found in the nucleoplasm in a mutant, but not in wild type. In some cases, there may be enough additional information to annotate to 'abnormal protein localization' (FYPO:0000443) or one of its descendants. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "ectopic protein localization to nucleoplasm" EXACT [PomBase:vw] synonym: "protein mislocalised to nucleoplasm" EXACT [PomBase:mah] synonym: "protein mislocalised to nucleoplasm during vegetative growth" EXACT [PomBase:mah] synonym: "protein mislocalized to nucleoplasm during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein mislocalized to nucleoplasm during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000782 ! mislocalized protein during vegetative growth intersection_of: PATO:0000628 ! mislocalised intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CHEBI:36080 ! protein intersection_of: towards GO:0005654 ! nucleoplasm relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CHEBI:36080 ! protein relationship: output_of FYPO:0002529 ! abnormal protein localization to nucleoplasm relationship: towards GO:0005654 ! nucleoplasm created_by: midori creation_date: 2013-11-05T15:59:55Z [Term] id: FYPO:0002844 name: inviable microcolony, swollen elongated septated cells def: "A cell population phenotype in which a cell undergoes one or a few rounds of cell division before cells die, resulting in the formation a colony that contains only a few inviable cells which are septated, longer than normal, and have a larger than normal cell volume. Up to 6 rounds of cell division (generating 64 cells) may be observed, but 3 divisions or fewer is more typical." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because it is redundant with annotating to the equivalent cell phenotype, with penetrance extensions where needed. synonym: "inviable microcolony, enlarged long septated vegetative cells" RELATED [PomBase:mah] synonym: "inviable microcolony, large elongated septated vegetative cells" RELATED [PomBase:vw] synonym: "inviable microcolony, swollen elongated septated vegetative cells" EXACT [PomBase:vw] is_obsolete: true created_by: midori creation_date: 2013-11-05T16:02:59Z [Term] id: FYPO:0002845 name: inviable swollen elongated septated cell def: "A cell morphology phenotype in which a vegetative cell is inviable, is swollen, is longer than normal, and contains one or more septa. In a swollen cell, both length and diameter are greater than normal, although the cell is only considered elongated if the length:width ratio is also greater than normal." [PomBase:mah] comment: The distinction between this phenotype and centrally constricted (dumbbell-shaped) cells (FYPO:0000779) is that swollen elongated cells do not have a constriction along the long axis. Swollen elongated cells may have a uniform diameter, or may be swollen only around the nucleus. synonym: "inviable enlarged elongated septated cell with enlarged nucleus" RELATED [PomBase:mah] synonym: "inviable large elongated septated cell" RELATED [PomBase:vw] synonym: "inviable swollen elongated septated vegetative cell" EXACT [PomBase:mah] is_a: FYPO:0002251 ! inviable swollen elongated vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000025 ! swollen cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0002342 ! septated vegetative cell relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000025 ! swollen cell relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0002342 ! septated vegetative cell created_by: midori creation_date: 2013-11-05T16:06:04Z [Term] id: FYPO:0002846 name: inviable mixed population including spores, germinated spores and small cells def: "A mixed population phenotype in which all cells in a population are inviable, and the population includes a mixture of ungerminated spores, germinated spores and small vegetative cells. The spheroid cells arise from division of some of the germinated spores, and may form a microcolony of up to 64 cells." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because a "mixed population" observation would be better represented as two or more separate phenotype annotations, each with penetrance specified. synonym: "essential; mixed population including spores, germinated spores and small cells" RELATED [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2013-11-05T16:59:57Z [Term] id: FYPO:0002847 name: decreased protein level in proteasome def: "A cell phenotype in which the amount of a protein measured in the proteasome is lower than normal when the cell is in the vegetative growth phase of the life cycle." [PMID:22906049, PomBase:mah] comment: Use this term for cases where the relative abundance of one or more specific proteins in the proteasome is decreased, altering the proteasome stoichiometry. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased proteasomal protein level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein level in proteasome during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein level in proteasome during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein level in proteasome" EXACT [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: FYPO:0001324 ! decreased protein level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000502 ! proteasome complex intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000502 ! proteasome complex relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2013-11-08T11:53:44Z [Term] id: FYPO:0002848 name: T-shaped cell during recovery from stationary phase def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a new growth zone forms along the lateral portion of the cell (often in the middle) before septation, such that a single cell grows in the form of the letter T, when the cell population has been in stationary phase and is then placed in conditions that allow recovery." [PomBase:jh, PomBase:mah] synonym: "T-shaped cell during recovery from stationary phase during mitotic cell cycle" RELATED [PomBase:mah] synonym: "T-shaped cell during vegetative growth following stationary phase" EXACT [PomBase:mah] is_a: FYPO:0000013 ! T-shaped vegetative cell created_by: midori creation_date: 2013-11-08T12:07:19Z [Term] id: FYPO:0002849 name: curved cell during recovery from stationary phase def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is curved when the cell population has been in stationary phase and is then placed in conditions that allow recovery. In a curved cell, the long axis follows a smooth bend rather than a straight line." [PomBase:jh, PomBase:mah] synonym: "comma-shaped cell during recovery from stationary phase" EXACT [PomBase:mah] synonym: "curved cell during recovery from stationary phase during mitotic cell cycle" RELATED [PomBase:mah] synonym: "curved cell during vegetative growth following stationary phase" EXACT [PomBase:mah] is_a: FYPO:0000016 ! curved vegetative cell created_by: midori creation_date: 2013-11-08T12:12:46Z [Term] id: FYPO:0002850 name: normal cell morphology during recovery from stationary phase def: "A cell phenotype characterized by normal cell morphology (i.e. size, shape, and structure) when the cell population has been in stationary phase and is then placed in conditions that allow recovery." [PomBase:mah] is_a: FYPO:0001315 ! normal vegetative cell morphology created_by: midori creation_date: 2013-11-08T12:18:07Z [Term] id: FYPO:0002851 name: protein mislocalized to eisosome def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a protein that is not normally found at the eisosome is observed there." [PomBase:mah] comment: Note that this term can be used to annotate any case where a protein is found in the eisosome in a mutant, but not in wild type. In some cases, there may be enough additional information to annotate to 'abnormal protein localization' (FYPO:0000443) or one of its descendants. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "ectopic protein localization to eisosome" EXACT [PomBase:vw] synonym: "protein mislocalised to eisosome" EXACT [PomBase:mah] synonym: "protein mislocalised to eisosome during vegetative growth" EXACT [PomBase:mah] synonym: "protein mislocalized to eisosome during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein mislocalized to eisosome during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000782 ! mislocalized protein during vegetative growth intersection_of: PATO:0000628 ! mislocalised intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CHEBI:36080 ! protein intersection_of: towards GO:0032126 ! eisosome relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CHEBI:36080 ! protein relationship: towards GO:0032126 ! eisosome created_by: midori creation_date: 2013-11-08T13:07:40Z [Term] id: FYPO:0002852 name: increased protein localization to cell tip def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the cell tip is increased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to cell tip" EXACT [GO:0034504, PomBase:mah] synonym: "increased protein localization to cell tip during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein localization to cell tip during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001584 ! abnormal protein localization to cell tip is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990151 ! protein localization to cell tip relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990151 ! protein localization to cell tip created_by: midori creation_date: 2013-11-08T13:18:06Z [Term] id: FYPO:0002853 name: abnormal glutamate-cysteine ligase activity def: "A molecular function phenotype in which the observed rate of glutamate-cysteine ligase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004357 ! glutamate-cysteine ligase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004357 ! glutamate-cysteine ligase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-11-08T13:33:31Z [Term] id: FYPO:0002854 name: abolished glutamate-cysteine ligase activity def: "A molecular function phenotype in which glutamate-cysteine ligase activity is absent." [PomBase:mah] synonym: "glutamate-cysteine ligase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0002853 ! abnormal glutamate-cysteine ligase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0004357 ! glutamate-cysteine ligase activity relationship: towards GO:0004357 ! glutamate-cysteine ligase activity created_by: midori creation_date: 2013-11-08T13:33:38Z [Term] id: FYPO:0002855 name: decreased glutamate-cysteine ligase activity def: "A molecular function phenotype in which the observed rate of glutamate-cysteine ligase activity is decreased." [PomBase:mah] synonym: "reduced glutamate-cysteine ligase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0002853 ! abnormal glutamate-cysteine ligase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004357 ! glutamate-cysteine ligase activity relationship: inheres_in GO:0004357 ! glutamate-cysteine ligase activity created_by: midori creation_date: 2013-11-08T13:33:47Z [Term] id: FYPO:0002856 name: abnormal glutathione synthase activity def: "A molecular function phenotype in which the observed rate of glutathione synthase activity is abnormal." [PomBase:mah] synonym: "abnormal glutathione synthetase activity" EXACT [GO:0004363] synonym: "abnormal GSH synthase activity" EXACT [GO:0004363] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004363 ! glutathione synthase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004363 ! glutathione synthase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-11-29T14:34:56Z [Term] id: FYPO:0002857 name: abolished glutathione synthase activity def: "A molecular function phenotype in which glutathione synthase activity is absent." [PomBase:mah] synonym: "abolished glutathione synthetase activity" EXACT [GO:0004363] synonym: "abolished GSH synthase activity" EXACT [GO:0004363] synonym: "phosphoribosylformylglycinamidine cyclo-ligase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0002856 ! abnormal glutathione synthase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0004363 ! glutathione synthase activity relationship: towards GO:0004363 ! glutathione synthase activity created_by: midori creation_date: 2012-11-29T14:35:04Z [Term] id: FYPO:0002858 name: increased (1->3)-beta-D-glucan level at cell tip def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of (1->3)-beta-D-glucan measured at the cell tip is greater than normal." [PMID:17581129, PMID:21652630, PomBase:mah] comment: This term can be used when increased Calcofluor White staining is observed at the cell tip, as Calcofluor White binds specifically to linear (1->3)-beta-D-glucans in fission yeast. synonym: "increased (1,3)beta-D-glucan level at cell tip" EXACT [PomBase:mah] synonym: "increased (1->3)-beta-D-glucan accumulation at cell tip" RELATED [PomBase:mah] synonym: "increased (1->3)-beta-D-glucan level at cell tip during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased (1->3)-beta-D-glucan level at cell tip during vegetative growth" EXACT [PomBase:mah] synonym: "increased 1,3-beta-D-glucan level at cell tip" EXACT [CHEBI:37671] synonym: "increased level of (1->3)-beta-D-glucan at cell tip" EXACT [PomBase:mah] synonym: "septal material present at cell tip" RELATED [PMID:21652630, PomBase:al] synonym: "septum material present at cell tip" RELATED [PMID:8978671, PomBase:al] is_a: FYPO:0001083 ! increased polysaccharide level is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051286 ! cell tip intersection_of: towards CHEBI:37671 ! (1->3)-beta-D-glucan relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051286 ! cell tip relationship: towards CHEBI:37671 ! (1->3)-beta-D-glucan created_by: midori creation_date: 2013-11-08T14:19:44Z [Term] id: FYPO:0002859 name: abolished protein localization to non-growing cell tip def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the non-growing cell tip is abolished. The new cell tip formed upon cell division does not grow until after new end take-off." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to non-growing cell tip" EXACT [PomBase:mah] synonym: "abolished protein localization to new cell end" RELATED [PomBase:mah] synonym: "abolished protein localization to new cell tip" RELATED [PomBase:mah] synonym: "abolished protein localization to non-growing cell end" EXACT [PomBase:mah] synonym: "abolished protein localization to non-growing cell tip during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to non-growing cell tip during vegetative growth" EXACT [PomBase:mah] synonym: "protein localization to non-growing cell tip abolished" EXACT [PomBase:mah] is_a: FYPO:0001585 ! abolished protein localization to cell tip intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1902487 ! protein localization to non-growing cell tip relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1902487 ! protein localization to non-growing cell tip created_by: midori creation_date: 2013-11-11T15:28:40Z [Term] id: FYPO:0002860 name: abnormal poly(U) polymerase activity def: "A molecular function phenotype in which the observed rate of polynucleotide uridylyltransferase activity is abnormal." [PMID:17449726, PomBase:mah] synonym: "abnormal polynucleotide uridylyltransferase activity" EXACT [PMID:17449726, PomBase:vw] synonym: "abnormal RNA uridylyltransferase activity" EXACT [GO:0050265] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0050265 ! RNA uridylyltransferase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0050265 ! RNA uridylyltransferase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-11-14T11:33:47Z [Term] id: FYPO:0002861 name: decreased poly(U) polymerase activity def: "A molecular function phenotype in which the observed rate of polynucleotide uridylyltransferase (poly(U) polymerase) activity is decreased." [PMID:17449726, PomBase:mah] synonym: "abnormal RNA uridylyltransferase activity" EXACT [GO:0050265] synonym: "decreased polynucleotide uridylyltransferase activity" EXACT [PMID:17449726, PomBase:vw] synonym: "reduced poly(U) polymerase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0002860 ! abnormal poly(U) polymerase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0050265 ! RNA uridylyltransferase activity relationship: inheres_in GO:0050265 ! RNA uridylyltransferase activity created_by: midori creation_date: 2013-11-14T11:33:54Z [Term] id: FYPO:0002862 name: abnormal cell growth def: "A cellular process phenotype in which cell growth is abnormal. Cell growth is the irreversible increase in size over time by accretion and biosynthetic production of matter similar to that already present." [GO:0016049, PomBase:mah] comment: Note that this term refers to growth, i.e. increase in size, of an individual cell. If you have measured the rate or extent of growth of a culture in liquid medium or on plates, use one of the 'cell population growth' terms. is_a: FYPO:0000628 ! abnormal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0016049 ! cell growth intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0016049 ! cell growth relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-11-14T12:08:41Z [Term] id: FYPO:0002863 name: slow cell growth during recovery from nitrogen starvation def: "A cellular process phenotype in which cells elongate more slowly than normal when the cells are returned to nitrogen-rich medium following nitrogen starvation." [PomBase:al, PomBase:mah] synonym: "slow cell growth during recovery from nitrogen depletion" EXACT [PomBase:vw] synonym: "slow cell growth during recovery from nitrogen deprivation" EXACT [PomBase:vw] is_a: FYPO:0002862 ! abnormal cell growth created_by: midori creation_date: 2013-11-14T12:12:23Z [Term] id: FYPO:0002864 name: resistance to 5-fluoroorotic acid def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of 5-fluoroorotic acid than normal." [PomBase:mah] synonym: "resistance to 5-fluoroorotic acid during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to 5-fluoroorotic acid during vegetative growth" EXACT [PomBase:mah] synonym: "resistance to 5-FOA" EXACT [PomBase:al] synonym: "resistant to 5-fluoroorotic acid" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:74498 ! 5-fluoroorotic acid relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:74498 ! 5-fluoroorotic acid created_by: midori creation_date: 2013-11-14T12:30:17Z [Term] id: FYPO:0002865 name: sensitive to polypeptone def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to polypeptone. Cells stop growing (and may die) at a concentration of polypeptone that allows wild type cells to grow. Polypeptone is a mixture of peptones made up of equal parts of pancreatic digest of casein and peptic digest of animal used in media." [http://www.bd.com/ds/productCenter/211910.asp, PomBase:mah] synonym: "hypersensitive to polypeptone" EXACT [PomBase:mah] synonym: "sensitive to polypeptone during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to polypeptone during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth created_by: midori creation_date: 2013-11-14T12:31:56Z [Term] id: FYPO:0002866 name: sensitive to tryptone def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to tryptone. Cells stop growing (and may die) at a concentration of tryptone that allows wild type cells to grow. Tryptone is a mixture of peptides produced by digestion of casein with trypsin." [http://www.bd.com/ds/productCenter/211701.asp, PomBase:mah] synonym: "hypersensitive to tryptone" EXACT [PomBase:mah] synonym: "sensitive to tryptone during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to tryptone during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth created_by: midori creation_date: 2013-11-14T12:35:33Z [Term] id: FYPO:0002867 name: increased cellular OMP level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of orotidine 5'-phosphate (orotidine monophosphate; OMP) measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular OMP level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular OMP level during vegetative growth" EXACT [PomBase:mah] synonym: "increased cellular orotidine 5'-(dihydrogen phosphate) level" EXACT [CHEBI:15842] synonym: "increased cellular orotidine monophosphate level" EXACT [PomBase:mah] synonym: "increased OMP accumulation" RELATED [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:15842 ! orotidine 5'-phosphate relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:15842 ! orotidine 5'-phosphate created_by: midori creation_date: 2013-11-14T13:46:17Z [Term] id: FYPO:0002868 name: increased cellular orotidine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of orotidine measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular orotidine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular orotidine level during vegetative growth" EXACT [PomBase:mah] synonym: "increased orotidine accumulation" RELATED [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:25722 ! orotidine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:25722 ! orotidine created_by: midori creation_date: 2013-11-14T13:48:06Z [Term] id: FYPO:0002869 name: decreased protein localization to cell division site def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the site of cell division is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to cell division site" EXACT [PomBase:mah] synonym: "decreased protein localization to cell division site during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to cell division site during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to cell division site" EXACT [PomBase:mah] is_a: FYPO:0001401 ! abnormal protein localization to cell division site is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072741 ! protein localization to cell division site relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072741 ! protein localization to cell division site created_by: midori creation_date: 2013-11-14T14:02:17Z [Term] id: FYPO:0002870 name: increased protein localization to non-growing cell tip def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to a non-growing cell tip is increased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to non-growing cell tip" EXACT [GO:0034504, PomBase:mah] synonym: "increased protein localization to non-growing cell end" EXACT [PomBase:mah] synonym: "increased protein localization to non-growing cell tip during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein localization to non-growing cell tip during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002852 ! increased protein localization to cell tip intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902487 ! protein localization to non-growing cell tip relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902487 ! protein localization to non-growing cell tip created_by: midori creation_date: 2013-11-14T14:04:12Z [Term] id: FYPO:0002871 name: decreased protein localization to growing cell tip def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to a growing cell tip is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to growing cell tip" EXACT [PomBase:mah] synonym: "decreased protein localization to growing cell end" EXACT [PomBase:mah] synonym: "decreased protein localization to growing cell tip during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to growing cell tip during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to growing cell tip" EXACT [PomBase:mah] is_a: FYPO:0001586 ! decreased protein localization to cell tip intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902486 ! protein localization to growing cell tip relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902486 ! protein localization to growing cell tip created_by: midori creation_date: 2013-11-14T14:04:54Z [Term] id: FYPO:0002872 name: abnormal endoplasmic reticulum localization def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of the endoplasmic reticulum (ER) is abnormal. In fission yeast, the ER is normally located in the cell cortex and tethered to the plasma membrane." [PMID:23041194, PomBase:mah] synonym: "abnormal endoplasmic reticulum localisation" EXACT [PomBase:mah] synonym: "abnormal endoplasmic reticulum localization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal endoplasmic reticulum localization during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal ER localization" EXACT [PomBase:mah] is_a: FYPO:0001337 ! localization phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0051643 ! endoplasmic reticulum localization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0051643 ! endoplasmic reticulum localization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-11-14T14:17:54Z [Term] id: FYPO:0002873 name: normal septum orientation def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which a cell has a septum in the normal orientation perpendicular the long axis of the cell." [PomBase:mah] synonym: "normal septum orientation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal septum orientation during vegetative growth" EXACT [PomBase:mah] synonym: "normal septum position" RELATED [PomBase:mah] is_a: FYPO:0001313 ! normal subcellular component during vegetative growth is_a: FYPO:0002253 ! normal septum location is_a: PATO:0000133 ! orientation intersection_of: PATO:0000133 ! orientation intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000935 ! barrier septum intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000935 ! barrier septum relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-11-14T14:31:54Z [Term] id: FYPO:0002874 name: premature protein localization to medial cortex during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the medial cortex begins earlier than normal." [PomBase:mah] synonym: "advanced protein localization to medial cortex during vegetative growth" EXACT [PomBase:mah] synonym: "faster protein localization to medial cortex during vegetative growth" RELATED [PomBase:mah] synonym: "premature protein localisation to medial cortex during vegetative growth" EXACT [GO:0071574, PomBase:mah] synonym: "premature protein localization to medial cortex during mitotic cell cycle" RELATED [PomBase:mah] synonym: "premature protein localization to medial ring during vegetative growth" EXACT [GO:0031097, GO:0071574] is_a: FYPO:0000731 ! abnormal protein localization to medial cortex during vegetative growth is_a: PATO:0000694 ! premature intersection_of: PATO:0000694 ! premature intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071574 ! protein localization to medial cortex relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071574 ! protein localization to medial cortex created_by: midori creation_date: 2013-11-14T14:49:40Z [Term] id: FYPO:0002875 name: increased transcription def: "A cellular process phenotype in which transcription occurs to a greater extent than normal. All genes, or a specific subset of genes, may be affected." [PomBase:mah] comment: Use this term if there is evidence, such as labeled nucleotide incorporation, showing that transcription rather than RNA stability is affected; otherwise, use 'increased RNA level' (FYPO:0000825). is_a: FYPO:0000143 ! transcription regulation phenotype is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0006351 ! transcription, DNA-templated relationship: has_output FYPO:0001890 ! increased RNA level relationship: inheres_in GO:0006351 ! transcription, DNA-templated created_by: midori creation_date: 2013-11-14T15:19:36Z [Term] id: FYPO:0002876 name: decreased transcription def: "A cellular process phenotype in which transcription occurs to a lower extent than normal. All genes, or a specific subset of genes, may be affected." [PomBase:mah] comment: Use this term if there is evidence, such as labeled nucleotide incorporation, showing that transcription rather than RNA stability is affected; otherwise, use 'decreased RNA level' (FYPO:0000826). synonym: "reduced transcription" EXACT [PomBase:mah] is_a: FYPO:0000143 ! transcription regulation phenotype is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0006351 ! transcription, DNA-templated relationship: has_output FYPO:0000826 ! decreased RNA level relationship: inheres_in GO:0006351 ! transcription, DNA-templated created_by: midori creation_date: 2013-11-14T15:16:51Z [Term] id: FYPO:0002877 name: abolished transcription def: "A cellular process phenotype in which transcription does not occur. All genes, or a specific subset of genes, may be affected." [PomBase:mah] synonym: "transcription abolished" EXACT [PomBase:mah] is_a: FYPO:0002876 ! decreased transcription is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0006351 ! transcription, DNA-templated relationship: towards GO:0006351 ! transcription, DNA-templated created_by: midori creation_date: 2013-11-14T15:29:01Z [Term] id: FYPO:0002878 name: increased transcription during glucose starvation def: "A cellular process phenotype in which transcription occurs to a greater extent than normal when the cell is subject to glucose starvation. All genes, or a specific subset of genes, may be affected." [PomBase:mah] synonym: "increased transcription during cellular response to glucose starvation" EXACT [PomBase:mah] synonym: "increased transcription during glucose depletion" EXACT [PomBase:vw] synonym: "increased transcription during glucose deprivation" EXACT [PomBase:vw] synonym: "increased transcription in response to glucose starvation" EXACT [PomBase:vw] is_a: FYPO:0002875 ! increased transcription intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0042149 ! cellular response to glucose starvation intersection_of: inheres_in GO:0006351 ! transcription, DNA-templated relationship: happens_during GO:0042149 ! cellular response to glucose starvation relationship: inheres_in GO:0006351 ! transcription, DNA-templated created_by: midori creation_date: 2013-11-14T15:30:22Z [Term] id: FYPO:0002879 name: abolished transcription during glucose starvation def: "A cellular process phenotype in which transcription does not occur when the cell is subject to glucose starvation. All genes, or a specific subset of genes, may be affected." [PomBase:mah] synonym: "abolished glucose deprivation induced gene expression" RELATED [PomBase:vw] synonym: "abolished transcription during cellular response to glucose starvation" EXACT [PomBase:mah] synonym: "abolished transcription during glucose depletion" EXACT [PomBase:vw] synonym: "abolished transcription during glucose deprivation" EXACT [PomBase:vw] synonym: "abolished transcription during glucose starvation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished transcription during glucose starvation during vegetative growth" EXACT [PomBase:mah] synonym: "abolished transcription in response to glucose starvation" EXACT [PomBase:vw] synonym: "transcription abolished during glucose starvation" EXACT [PomBase:mah] is_a: FYPO:0002877 ! abolished transcription is_a: FYPO:0003120 ! decreased transcription during glucose starvation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: happens_during GO:0042149 ! cellular response to glucose starvation intersection_of: towards GO:0006351 ! transcription, DNA-templated relationship: happens_during GO:0042149 ! cellular response to glucose starvation relationship: towards GO:0006351 ! transcription, DNA-templated created_by: midori creation_date: 2013-11-14T15:30:46Z [Term] id: FYPO:0002880 name: decreased transcription during glucose starvation and oxidative stress def: "A cellular process phenotype in which transcription occurs to a lower extent than normal when the cell is subject to glucose starvation and oxidative stress simultaneously. All genes, or a specific subset of genes, may be affected." [PomBase:mah] comment: Use this term if there is evidence, such as labeled nucleotide incorporation, showing that transcription rather than RNA stability is affected; otherwise, use 'decreased RNA level' (FYPO:0000826). synonym: "decreased transcription during cellular response to glucose starvation and oxidative stress" EXACT [PomBase:mah] synonym: "decreased transcription during glucose depletion and oxidative stress" EXACT [PomBase:vw] synonym: "decreased transcription during glucose deprivation and oxidative stress" EXACT [PomBase:vw] synonym: "decreased transcription in response to glucose starvation and oxidative stress" EXACT [PomBase:mah] synonym: "decreased transcription in response to glucose starvation during oxidative stress" EXACT [PomBase:vw] synonym: "reduced transcription during glucose starvation and oxidative stress" EXACT [PomBase:mah] is_a: FYPO:0003120 ! decreased transcription during glucose starvation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0034599 ! cellular response to oxidative stress intersection_of: happens_during GO:0042149 ! cellular response to glucose starvation intersection_of: inheres_in GO:0006351 ! transcription, DNA-templated relationship: happens_during GO:0034599 ! cellular response to oxidative stress relationship: happens_during GO:0042149 ! cellular response to glucose starvation relationship: inheres_in GO:0006351 ! transcription, DNA-templated created_by: midori creation_date: 2013-11-14T15:39:02Z [Term] id: FYPO:0002881 name: increased transcription during glucose starvation and oxidative stress def: "A cellular process phenotype in which transcription occurs to a greater extent than normal when the cell is subject to glucose starvation and oxidative stress simultaneously. All genes, or a specific subset of genes, may be affected." [PomBase:mah] comment: Use this term if there is evidence, such as labeled nucleotide incorporation, showing that transcription rather than RNA stability is affected; otherwise, use 'decreased RNA level' (FYPO:0000826). synonym: "increased transcription during glucose depletion and oxidative stress" EXACT [PomBase:vw] synonym: "increased transcription during glucose deprivation and oxidative stress" EXACT [PomBase:vw] synonym: "increased transcription in response to glucose starvation and oxidative stress" EXACT [PomBase:mah] synonym: "increased transcription in response to glucose starvation during oxidative stress" EXACT [PomBase:vw] is_a: FYPO:0002878 ! increased transcription during glucose starvation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0034599 ! cellular response to oxidative stress intersection_of: happens_during GO:0042149 ! cellular response to glucose starvation intersection_of: inheres_in GO:0006351 ! transcription, DNA-templated relationship: happens_during GO:0034599 ! cellular response to oxidative stress relationship: happens_during GO:0042149 ! cellular response to glucose starvation relationship: inheres_in GO:0006351 ! transcription, DNA-templated created_by: midori creation_date: 2013-11-14T15:42:43Z [Term] id: FYPO:0002882 name: normal transcription def: "A cellular process phenotype in which transcription occurs to a normal (i.e. indistinguishable from wild type) extent. All genes, or a specific subset of genes, may be measured." [PomBase:mah] synonym: "normal transcription, DNA-dependent" EXACT [GO:0006351] is_a: FYPO:0002496 ! normal metabolic process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0006351 ! transcription, DNA-templated intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0006351 ! transcription, DNA-templated relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-11-14T15:45:53Z [Term] id: FYPO:0002883 name: normal transcription during glucose starvation def: "A cellular process phenotype in which transcription occurs to a normal (i.e. indistinguishable from wild type) extent when the cell is subject to glucose starvation. All genes, or a specific subset of genes, may be measured." [PomBase:mah] synonym: "normal transcription during cellular response to glucose starvation" EXACT [PomBase:mah] synonym: "normal transcription during glucose depletion" EXACT [PomBase:vw] synonym: "normal transcription during glucose deprivation" EXACT [PomBase:vw] synonym: "normal transcription in response to glucose starvation" EXACT [PomBase:vw] is_a: FYPO:0002882 ! normal transcription intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0042149 ! cellular response to glucose starvation intersection_of: inheres_in GO:0006351 ! transcription, DNA-templated intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0042149 ! cellular response to glucose starvation relationship: inheres_in GO:0006351 ! transcription, DNA-templated relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-11-14T15:51:50Z [Term] id: FYPO:0002884 name: normal transcription during cellular response to osmotic stress def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription occurs to a normal (i.e. indistinguishable from wild type) extent during a cellular response to osmotic stress. All genes, or a specific subset of genes, may be measured." [PomBase:mah] synonym: "normal transcription during cellular response to osmotic stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal transcription during cellular response to osmotic stress during vegetative growth" EXACT [PomBase:mah] synonym: "normal transcription in response to osmotic stress" EXACT [PomBase:vw] is_a: FYPO:0001855 ! normal transcription during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0071470 ! cellular response to osmotic stress intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006351 ! transcription, DNA-templated intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0071470 ! cellular response to osmotic stress relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006351 ! transcription, DNA-templated relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-11-14T16:08:33Z [Term] id: FYPO:0002885 name: normal transcription during cellular response to oxidative stress def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription occurs to a normal (i.e. indistinguishable from wild type) extent during a cellular response to oxidative stress. All genes, or a specific subset of genes, may be measured." [PomBase:mah] synonym: "normal transcription during cellular response to oxidative stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal transcription during cellular response to oxidative stress during vegetative growth" EXACT [PomBase:mah] synonym: "normal transcription in response to oxidative stress" EXACT [PomBase:vw] is_a: FYPO:0001855 ! normal transcription during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0034599 ! cellular response to oxidative stress intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006351 ! transcription, DNA-templated intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0034599 ! cellular response to oxidative stress relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006351 ! transcription, DNA-templated relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-11-14T16:10:17Z [Term] id: FYPO:0002886 name: normal transcription during cellular response to heavy metal stress def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription occurs to a normal (i.e. indistinguishable from wild type) extent during a cellular response to heavy metal stress. All genes, or a specific subset of genes, may be measured." [PomBase:mah] synonym: "normal transcription during cellular response to heavy metal stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal transcription during cellular response to heavy metal stress during vegetative growth" EXACT [PomBase:mah] synonym: "normal transcription in response to heavy metal stress" EXACT [PomBase:vw] is_a: FYPO:0001855 ! normal transcription during vegetative growth created_by: midori creation_date: 2013-11-14T16:10:54Z [Term] id: FYPO:0002887 name: normal protein localization to telomere during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the telomere of a chromosome is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to chromosome, telomeric region, during vegetative growth" EXACT [GO:0070198, PomBase:mah] synonym: "normal protein localisation to telomere during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein localization to chromosome, telomeric region, during vegetative growth" EXACT [GO:0070198, PomBase:mah] synonym: "normal protein localization to telomere during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000644 ! normal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0070198 ! protein localization to chromosome, telomeric region intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0070198 ! protein localization to chromosome, telomeric region relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-11-14T16:13:58Z [Term] id: FYPO:0002888 name: mitotic cell cycle arrest before cell separation def: "A cellular process phenotype in which the mitotic cell cycle is arrested after the septum has formed, but before cells have separated, under conditions where arrest does not normally occur." [PMID:8978671, PomBase:mah] synonym: "mitotic cell cycle arrest before cell separation after cytokinesis" EXACT [GO:0000920] synonym: "mitotic cell cycle arrest before cell separation during vegetative growth" EXACT [PomBase:mah] synonym: "mitotic cell cycle arrest before mitotic cytokinetic cell separation" EXACT [GO:0000920] is_a: FYPO:0000502 ! abnormally arrested mitotic cell cycle progression is_a: FYPO:0004040 ! mitotic cell cycle arrest phenotype intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071850 ! mitotic cell cycle arrest intersection_of: precedes GO:0000920 ! cell separation after cytokinesis intersection_of: qualifier PATO:0000467 ! present relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071850 ! mitotic cell cycle arrest relationship: precedes GO:0000920 ! cell separation after cytokinesis relationship: qualifier PATO:0000467 ! present created_by: midori creation_date: 2013-11-19T12:13:06Z [Term] id: FYPO:0002889 name: inviable elongated vegetative cell with abnormal septum def: "A cell morphology phenotype in which a vegetatively growing cell is inviable, is longer than normal, and contains one or more abnormal septa." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "elongated inviable cell with abnormal septum" EXACT [PomBase:mah] synonym: "inviable elongated abnormally septated vegetative cell" EXACT [PomBase:mah, PomBase:vw] synonym: "inviable elongated cell with abnormal septum during vegetative growth" EXACT [PomBase:mah] synonym: "inviable elongated vegetative cell with abnormal septum during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001490 ! inviable elongated vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0002455 ! abnormal septum during vegetative growth relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0002455 ! abnormal septum during vegetative growth created_by: midori creation_date: 2013-11-19T12:47:35Z [Term] id: FYPO:0002890 name: abnormal horsetail nucleus morphology def: "A physical cellular phenotype in which the size, shape, or structure of the horsetail nucleus is abnormal. The horsetail nucleus forms during the rapid oscillatory movement at meiotic prophase I." [PomBase:mah] comment: Note that an abnormal nucleus organization process may, but does not necessarily, result in abnormal nuclear morphology. Consider also annotating to 'abnormal horsetail movement' (FYPO:0000197). synonym: "abnormal horsetail nuclear morphology" EXACT [PomBase:mah] is_a: FYPO:0002256 ! abnormal nuclear morphology intersection_of: PATO:0000051 ! morphology intersection_of: inheres_in GO:0071686 ! horsetail nucleus intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0071686 ! horsetail nucleus relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-11-19T12:50:32Z [Term] id: FYPO:0002891 name: normal chromatin organization during vegetative growth def: "A cellular process phenotype in which any process of chromatin organization is normal (i.e. indistinguishable from wild type) in the vegetative growth phase of the life cycle. Chromatin organization results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GO:0006325, PomBase:mah] synonym: "normal chromatin organisation during vegetative growth" EXACT [PomBase:mah] synonym: "normal chromatin organization during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001319 ! normal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006325 ! chromatin organization intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006325 ! chromatin organization relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-11-19T13:34:36Z [Term] id: FYPO:0002892 name: normal heterochromatin organization during vegetative growth def: "A cellular process phenotype in which any process of heterochromatin organization is normal (i.e. indistinguishable from wild type) in the vegetative growth phase of the life cycle. Heterochromatin organization results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin." [GO:0070828, PomBase:mah] synonym: "normal heterochromatin organisation during vegetative growth" EXACT [PomBase:mah] synonym: "normal heterochromatin organization during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0002891 ! normal chromatin organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0070828 ! heterochromatin organization intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0070828 ! heterochromatin organization relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-11-19T13:35:34Z [Term] id: FYPO:0002893 name: decreased repression of transcription during cellular response to cAMP def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which negative regulation of transcription from RNA polymerase II promoter occurs to a lower extent than normal during a cellular response to cAMP. Specific genes are more highly transcribed in the presence of cAMP in the mutant than in wild type." [PMID:22496451, PomBase:mah] synonym: "decreased negative regulation of transcription from RNA polymerase II promoter during cellular response to cAMP" EXACT [GO:0000122, PomBase:mah] synonym: "decreased repression of transcription during cellular response to cAMP during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased repression of transcription during cellular response to cAMP during vegetative growth" EXACT [PomBase:mah] synonym: "decreased transcriptional repression during cellular response to cAMP" EXACT [PomBase:mah] synonym: "reduced repression of transcription during cellular response to cAMP" EXACT [PomBase:mah] is_a: FYPO:0000624 ! abnormal negative regulation of transcription during vegetative growth is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0071320 ! cellular response to cAMP intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter relationship: happens_during GO:0071320 ! cellular response to cAMP relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter created_by: midori creation_date: 2013-11-19T13:43:15Z [Term] id: FYPO:0002894 name: decreased transcription during cellular response to calcium ion def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription occurs to a lower extent than normal during a cellular response to calcium ions. All genes, or a specific subset of genes, may be affected." [PomBase:mah] synonym: "decreased transcription during cellular response to calcium" EXACT [PomBase:mah] synonym: "decreased transcription during cellular response to calcium ion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased transcription during cellular response to calcium ion during vegetative growth" EXACT [PomBase:mah] synonym: "decreased transcription in response to calcium" EXACT [PomBase:mah] synonym: "reduced transcription during cellular response to calcium ion" EXACT [PomBase:mah] is_a: FYPO:0000781 ! decreased transcription during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0071277 ! cellular response to calcium ion intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006351 ! transcription, DNA-templated relationship: happens_during GO:0071277 ! cellular response to calcium ion relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006351 ! transcription, DNA-templated created_by: midori creation_date: 2013-11-19T14:11:53Z [Term] id: FYPO:0002895 name: increased transcription during cellular response to calcium ion def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription occurs to a greater extent than normal during a cellular response to calcium ions. All genes, or a specific subset of genes, may be affected." [PomBase:mah] synonym: "increased transcription during cellular response to calcium" EXACT [PomBase:mah] synonym: "increased transcription during cellular response to calcium ion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased transcription during cellular response to calcium ion during vegetative growth" EXACT [PomBase:mah] synonym: "increased transcription in response to calcium" EXACT [PomBase:mah] is_a: FYPO:0000780 ! increased transcription during vegetative growth intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0071277 ! cellular response to calcium ion intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006351 ! transcription, DNA-templated relationship: happens_during GO:0071277 ! cellular response to calcium ion relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006351 ! transcription, DNA-templated created_by: midori creation_date: 2013-11-19T14:14:49Z [Term] id: FYPO:0002896 name: normal transcription during cellular response to calcium ion def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription occurs to a normal (i.e. indistinguishable from wild type) extent during a cellular response to calcium ions. All genes, or a specific subset of genes, may be measured." [PomBase:mah] synonym: "normal transcription during cellular response to calcium" EXACT [PomBase:mah] synonym: "normal transcription during cellular response to calcium ion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal transcription during cellular response to calcium ion during vegetative growth" EXACT [PomBase:mah] synonym: "normal transcription in response to calcium" EXACT [PomBase:mah] is_a: FYPO:0001855 ! normal transcription during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0071277 ! cellular response to calcium ion intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006351 ! transcription, DNA-templated intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0071277 ! cellular response to calcium ion relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006351 ! transcription, DNA-templated relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-11-19T14:16:00Z [Term] id: FYPO:0002897 name: decreased protein phosphorylation during cellular response to DNA damage def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal during a cellular response to a DNA damage stimulus." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein phosphorylation during cellular response to DNA damage during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein phosphorylation during cellular response to DNA damage during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein phosphorylation during cellular response to DNA damage" EXACT [PomBase:mah] is_a: FYPO:0001838 ! decreased protein phosphorylation during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0006974 ! cellular response to DNA damage stimulus intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0006974 ! cellular response to DNA damage stimulus relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2013-11-19T14:20:10Z [Term] id: FYPO:0002898 name: abolished protein phosphorylation during cellular response to DNA damage def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, does not occur during a cellular response to a DNA damage stimulus." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein phosphorylation during cellular response to DNA damage during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein phosphorylation during cellular response to DNA damage during vegetative growth" EXACT [PomBase:mah] synonym: "protein phosphorylation abolished during cellular response to DNA damage" EXACT [PomBase:mah] is_a: FYPO:0002033 ! abolished protein phosphorylation during vegetative growth intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0006974 ! cellular response to DNA damage stimulus intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0006468 ! protein phosphorylation relationship: during GO:0006974 ! cellular response to DNA damage stimulus relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2013-11-19T14:21:29Z [Term] id: FYPO:0002899 name: normal protein phosphorylation during cellular response to DNA damage def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins is normal (i.e. indistinguishable from wild type) during a cellular response to a DNA damage stimulus." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein phosphorylation during cellular response to DNA damage during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein phosphorylation during cellular response to DNA damage during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000776 ! normal protein phosphorylation during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0006974 ! cellular response to DNA damage stimulus intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0006974 ! cellular response to DNA damage stimulus relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-11-19T14:22:49Z [Term] id: FYPO:0002900 name: abnormal DNA damage checkpoint during cellular response to UV def: "A cell cycle checkpoint phenotype in which any DNA damage checkpoint is abnormal when the cell is exposed to ultraviolet light. A DNA damage checkpoint normally regulates progression through the cell cycle in response to DNA damage." [PomBase:mah] synonym: "abnormal DNA damage checkpoint activation during cellular response to UV" EXACT [PomBase:al] synonym: "abnormal DNA damage checkpoint during cellular response to ultraviolet light" EXACT [PomBase:mah] synonym: "abnormal DNA damage checkpoint during cellular response to UV during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal DNA damage checkpoint during cellular response to UV during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000006 ! abnormal DNA damage checkpoint intersection_of: PATO:0000001 ! quality intersection_of: during GO:0034644 ! cellular response to UV intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000077 ! DNA damage checkpoint intersection_of: qualifier PATO:0000460 ! abnormal relationship: during GO:0034644 ! cellular response to UV relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000077 ! DNA damage checkpoint relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-11-19T14:24:36Z [Term] id: FYPO:0002901 name: normal protein localization to kinetochore def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the kinetochore of a chromosome is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to kinetochore" EXACT [PomBase:mah] synonym: "normal protein localization to kinetochore during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to kinetochore during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002574 ! normal protein localization to centromere intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034501 ! protein localization to kinetochore intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034501 ! protein localization to kinetochore relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-11-19T16:42:18Z [Term] id: FYPO:0002902 name: decreased protein localization to kinetochore during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the kinetochore of a chromosome is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to kinetochore during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein localization to kinetochore during mitotic cell cycle" RELATED [PomBase:mah] synonym: "reduced protein localization to kinetochore during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000450 ! decreased protein localization to centromere is_a: FYPO:0001268 ! abnormal protein localization to kinetochore during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034501 ! protein localization to kinetochore relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034501 ! protein localization to kinetochore created_by: midori creation_date: 2013-11-19T16:43:34Z [Term] id: FYPO:0002903 name: viable pear-shaped vegetative cell def: "A cell morphology phenotype in which a cell is viable and shaped in the form of a pear in the vegetative growth phase of the life cycle. One end is rounded, while the other resembles an end of a normal rod-shaped cell. The normally shaped end has the same diameter as a wild-type cell." [PomBase:mah] synonym: "viable ice cream cone-shaped cell during vegetative growth" EXACT [PMID:2236039, PomBase:vw] synonym: "viable pear-shaped cell during vegetative growth" EXACT [PomBase:mah] synonym: "viable pear-shaped vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0002197 ! viable vegetative cell with abnormal cell shape intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000020 ! pear-shaped cell intersection_of: has_part FYPO:0001491 ! viable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000020 ! pear-shaped cell relationship: has_part FYPO:0001491 ! viable vegetative cell created_by: midori creation_date: 2013-11-20T12:11:07Z [Term] id: FYPO:0002904 name: inviable pear-shaped vegetative cell def: "A cell morphology phenotype in which a cell is inviable and shaped in the form of a pear in the vegetative growth phase of the life cycle. One end is rounded, while the other resembles an end of a normal rod-shaped cell. The normally shaped end has the same diameter as a wild-type cell." [PomBase:mah] synonym: "inviable ice cream cone-shaped cell during vegetative growth" EXACT [PMID:2236039, PomBase:vw] synonym: "inviable pear-shaped cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable pear-shaped vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0002451 ! inviable vegetative cell with abnormal cell shape intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000020 ! pear-shaped cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000020 ! pear-shaped cell relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2013-11-20T12:12:02Z [Term] id: FYPO:0002905 name: normal telomere maintenance def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which telomere maintenance, i.e. any process that contributes to the maintenance of proper telomeric length and structure, is normal (i.e. indistinguishable from wild type)." [GO:0000723, PomBase:mah] synonym: "normal telomere maintenance during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal telomere maintenance during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000859 ! normal metabolic process during vegetative growth is_a: FYPO:0001346 ! DNA metabolism phenotype during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000723 ! telomere maintenance intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000723 ! telomere maintenance relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-11-26T11:16:57Z [Term] id: FYPO:0002906 name: increased antisense primary transcript splicing def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of splicing of antisense RNA primary transcripts is increased." [PomBase:mah] synonym: "increased antisense primary transcript RNA splicing" EXACT [PomBase:mah] synonym: "increased antisense primary transcript splicing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased antisense primary transcript splicing during vegetative growth" EXACT [PomBase:mah] synonym: "increased antisense primary transcript splicing, via transesterification reactions with bulged adenosine as nucleophile" EXACT [GO:0000377] is_a: FYPO:0002916 ! increased RNA splicing intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile intersection_of: towards SO:0000645 ! antisense_primary_transcript relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile relationship: towards SO:0000645 ! antisense_primary_transcript created_by: midori creation_date: 2013-11-27T14:11:37Z [Term] id: FYPO:0002907 name: circularized chromosome during mitotic G1 phase def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which telomeres have fused, forming circular chromosomes, during G1 phase of the mitotic cell cycle." [PMID:23133674, PomBase:mah] synonym: "circular chromosomes during mitotic G1 phase" EXACT [PomBase:mah] synonym: "circularised chromosome during mitotic G1 phase" EXACT [PomBase:mah] synonym: "circularized chromosome during G1 during vegetative growth" EXACT [PomBase:mah] synonym: "fused telomeres during mitotic G1 phase" RELATED [PomBase:mah] synonym: "telomere end fusion during mitotic G1 phase" RELATED [PomBase:mah] synonym: "telomere fusion during mitotic G1 phase" RELATED [PomBase:mah] synonym: "telomeres fused during mitotic G1 phase" RELATED [PomBase:mah] is_a: FYPO:0002702 ! circularized chromosome created_by: midori creation_date: 2013-11-26T11:25:59Z [Term] id: FYPO:0002908 name: increased transcription at telomere def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription occurs to a greater extent than normal in telomeric regions. All genes, or a specific subset of genes, may be affected." [PomBase:mah] synonym: "increased transcription at telomere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased transcription at telomere during vegetative growth" EXACT [PomBase:mah] synonym: "increased transcription from telomere" EXACT [PomBase:al] synonym: "increased transcription from telomere during vegetative growth" EXACT [PomBase:al] is_a: FYPO:0000780 ! increased transcription during vegetative growth intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006351 ! transcription, DNA-templated intersection_of: occurs_at SO:0000624 ! telomere relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006351 ! transcription, DNA-templated relationship: occurs_at SO:0000624 ! telomere created_by: midori creation_date: 2013-11-26T11:29:03Z [Term] id: FYPO:0002909 name: decreased protein localization to chromatin during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to chromatin is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to chromatin during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein localization to chromatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "reduced protein localization to chromatin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000452 ! abnormal protein localization to chromatin during vegetative growth is_a: FYPO:0002839 ! decreased protein localization to chromosome intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071168 ! protein localization to chromatin relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071168 ! protein localization to chromatin created_by: midori creation_date: 2013-11-26T11:46:41Z [Term] id: FYPO:0002910 name: decreased protein localization to chromatin at transcribed regions during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to transcribed regions of chromatin is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to chromatin at transcribed regions during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein localization to chromatin at transcribed regions during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to transcribed chromatin regions during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to chromatin at transcribed regions during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002909 ! decreased protein localization to chromatin during vegetative growth created_by: midori creation_date: 2013-11-26T11:59:17Z [Term] id: FYPO:0002911 name: inviable after spore germination, without cell division, with swollen elongated germ tube def: "A phenotype in which a spore germinates to produce an elongated germ tube that has a larger diameter and volume than normal, and does not go on to form a viable dividing cell." [PomBase:mah] synonym: "essential; germinating spore with swollen elongated germ tube" RELATED [PomBase:mah] synonym: "inviable after spore germination with elongated swollen germ tube" EXACT [PomBase:mah] synonym: "inviable after spore germination, without cell division, swollen elongated cell" RELATED [PomBase:mah] synonym: "inviable following spore germination with swollen elongated germ tube" EXACT [PomBase:mah] synonym: "inviable germinated spore with swollen elongated germ tube" EXACT [PomBase:mah] is_a: FYPO:0002251 ! inviable swollen elongated vegetative cell is_a: FYPO:0002379 ! inviable after spore germination, without cell division, with elongated germ tube is_a: FYPO:0002415 ! inviable swollen vegetative cell with abnormal cell shape created_by: midori creation_date: 2013-11-26T12:14:08Z [Term] id: FYPO:0002912 name: inviable after spore germination, without cell division, elongated multinucleate cell def: "A phenotype in which a spore germinates to produce an inviable cell that does not divide, is longer than normal, and contains more than one nucleus." [PomBase:mah] synonym: "essential; germinating spore, without cell division, elongated multinucleate cell" RELATED [PomBase:mah] synonym: "inviable after spore germination, multinucleate elongated cell" EXACT [PomBase:mah] synonym: "inviable after spore germination, undivided elongated multinucleate cell" EXACT [PomBase:mah] synonym: "inviable following spore germination, without cell division, elongated multinucleate cell" EXACT [PomBase:mah] synonym: "inviable germinated spore, without cell division, elongated multinucleate cell" EXACT [PomBase:mah] is_a: FYPO:0004603 ! inviable after spore germination, without cell division, elongated cell created_by: midori creation_date: 2013-11-26T12:18:40Z [Term] id: FYPO:0002913 name: increased antisense RNA transcription def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which antisense RNA transcription occurs to a greater extent than normal. All genes, or a specific subset of genes, may be affected." [PomBase:mah] synonym: "increased antisense RNA transcription during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased antisense RNA transcription during vegetative growth" EXACT [PomBase:mah] synonym: "increased antisense transcription" EXACT [PomBase:mah] synonym: "increased antisense transcription during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000780 ! increased transcription during vegetative growth intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0009300 ! antisense RNA transcription relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0009300 ! antisense RNA transcription created_by: midori creation_date: 2013-11-26T12:31:14Z [Term] id: FYPO:0002914 name: increased intergenic transcription def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription occurs to a greater extent than normal in intergenic regions. All genes, or a specific subset of genes, may be affected." [PomBase:mah] synonym: "increased intergenic transcription during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased transcription at intergenic regions during vegetative growth" EXACT [PomBase:mah] synonym: "increased transcription from intergenic regions" EXACT [PomBase:al] synonym: "increased transcription from intergenic regions during vegetative growth" EXACT [PomBase:al] is_a: FYPO:0000780 ! increased transcription during vegetative growth intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006351 ! transcription, DNA-templated intersection_of: occurs_at SO:0000605 ! intergenic_region relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006351 ! transcription, DNA-templated relationship: occurs_at SO:0000605 ! intergenic_region created_by: midori creation_date: 2013-11-26T12:45:48Z [Term] id: FYPO:0002915 name: abnormal RNA splicing def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which RNA splicing is abnormal. All RNA splicing may be abnormal, or one splicing of or more specific RNA molecules may be selectively affected." [PomBase:mah] synonym: "abnormal RNA splicing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal RNA splicing during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal RNA splicing, via transesterification reactions with bulged adenosine as nucleophile" EXACT [GO:0000377] is_a: FYPO:0001553 ! abnormal RNA processing intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-11-26T12:58:29Z [Term] id: FYPO:0002916 name: increased RNA splicing def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of RNA splicing is increased. All RNA splicing may be increased, or splicing of one or more specific RNA molecules may be selectively affected." [PomBase:mah] synonym: "increased RNA splicing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased RNA splicing during vegetative growth" EXACT [PomBase:mah] synonym: "increased RNA splicing, via transesterification reactions with bulged adenosine as nucleophile" EXACT [GO:0000377] is_a: FYPO:0002915 ! abnormal RNA splicing is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile created_by: midori creation_date: 2013-11-26T13:00:00Z [Term] id: FYPO:0002917 name: abolished histone H3-K4 methylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which methylation of lysine at position 4 of histone H3 does not occur." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished histone H3 K4 methylation" EXACT [GO:0051568, PomBase:mah] synonym: "abolished histone H3-K4 methylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished histone H3-K4 methylation during vegetative growth" EXACT [PomBase:mah] synonym: "abolished histone H3K4me" EXACT [GO:0051568, PomBase:mah] synonym: "abolished histone lysine H3 K4 methylation" EXACT [GO:0051568, PomBase:mah] synonym: "histone H3-K4 methylation abolished" EXACT [PomBase:mah] synonym: "histone H3-K4 methylation absent" EXACT [PomBase:mah] is_a: FYPO:0002330 ! abnormal histone H3-K4 methylation is_a: FYPO:0002565 ! abolished histone methylation is_a: FYPO:0004488 ! abolished protein lysine methylation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0051568 ! histone H3-K4 methylation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0051568 ! histone H3-K4 methylation created_by: midori creation_date: 2013-11-26T13:51:37Z [Term] id: FYPO:0002918 name: abnormal histone H3-K36 methylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which methylation of lysine at position 4 of histone H3 is abnormal." [PomBase:mah] synonym: "abnormal histone H3 K36 methylation" EXACT [GO:0010452, PomBase:mah] synonym: "abnormal histone H3-K36 methylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal histone H3-K36 methylation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal histone H3K36me" EXACT [GO:0010452, PomBase:mah] synonym: "abnormal histone lysine H3 K36 methylation" EXACT [GO:0010452, PomBase:mah] is_a: FYPO:0000457 ! abnormal histone methylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0010452 ! histone H3-K36 methylation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0010452 ! histone H3-K36 methylation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-11-26T13:54:30Z [Term] id: FYPO:0002919 name: abolished histone H3-K36 methylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which methylation of lysine at position 4 of histone H3 does not occur." [PomBase:mah] synonym: "abolished histone H3 K36 methylation" EXACT [GO:0010452, PomBase:mah] synonym: "abolished histone H3-K36 methylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished histone H3-K36 methylation during vegetative growth" EXACT [PomBase:mah] synonym: "abolished histone H3K36me" EXACT [GO:0010452, PomBase:mah] synonym: "abolished histone lysine H3 K36 methylation" EXACT [GO:0010452, PomBase:mah] synonym: "histone H3-K36 methylation abolished" EXACT [PomBase:mah] synonym: "histone H3-K36 methylation absent" EXACT [PomBase:mah] is_a: FYPO:0002565 ! abolished histone methylation is_a: FYPO:0002918 ! abnormal histone H3-K36 methylation is_a: FYPO:0004488 ! abolished protein lysine methylation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0010452 ! histone H3-K36 methylation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0010452 ! histone H3-K36 methylation created_by: midori creation_date: 2013-11-26T13:54:53Z [Term] id: FYPO:0002920 name: normal histone H3-K36 methylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which methylation of lysine at position 36 of histone H3 is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal histone H3 K36 methylation" EXACT [GO:0010452, PomBase:mah] synonym: "normal histone H3-K36 methylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal histone H3-K36 methylation during vegetative growth" EXACT [PomBase:mah] synonym: "normal histone H3K36me" EXACT [GO:0010452, PomBase:mah] synonym: "normal histone lysine H3 K36 methylation" EXACT [GO:0010452, PomBase:mah] is_a: FYPO:0000861 ! normal histone methylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0010452 ! histone H3-K36 methylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0010452 ! histone H3-K36 methylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-11-26T13:54:30Z [Term] id: FYPO:0002921 name: abnormal histone ubiquitination def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone ubiquitination is abnormal." [PomBase:mah] synonym: "abnormal histone ubiquitination during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal histone ubiquitination during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal histone ubiquitinylation" EXACT [GO:0016574] synonym: "abnormal histone ubiquitylation" EXACT [GO:0016574] is_a: FYPO:0000330 ! abnormal histone modification is_a: FYPO:0000905 ! abnormal protein ubiquitination intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0016574 ! histone ubiquitination intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0016574 ! histone ubiquitination relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-11-26T14:30:58Z [Term] id: FYPO:0002922 name: abolished histone H2B-K119 ubiquitination def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which ubiquitination of lysine at position 119 of histone H2B does not occur. Lysine 119 corresponds to the conserved C-terminal lysine of H2B." [PomBase:mah] synonym: "abolished histone H2B conserved C-terminal lysine ubiquitination" EXACT [GO:0071894] synonym: "abolished histone H2B-K119 ubiquitination during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished histone H2B-K119 ubiquitination during vegetative growth" EXACT [PomBase:mah] synonym: "histone H2B-K119 ubiquitination abolished" EXACT [PomBase:mah] synonym: "histone H2B-K119 ubiquitination absent" EXACT [PomBase:al] is_a: FYPO:0000912 ! abolished protein ubiquitination is_a: FYPO:0002921 ! abnormal histone ubiquitination intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0071894 ! histone H2B conserved C-terminal lysine ubiquitination relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0071894 ! histone H2B conserved C-terminal lysine ubiquitination created_by: midori creation_date: 2013-11-26T14:33:35Z [Term] id: FYPO:0002923 name: normal histone H2B-K119 ubiquitination def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which ubiquitination of lysine at position 119 of histone H2B is normal (i.e. indistinguishable from wild type). Lysine 119 corresponds to the conserved C-terminal lysine of H2B." [PomBase:mah] synonym: "normal histone H2B conserved C-terminal lysine ubiquitination" EXACT [GO:0071894, PomBase:mah] synonym: "normal histone H2B-K119 ubiquitination during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal histone H2B-K119 ubiquitination during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002600 ! normal histone modification is_a: FYPO:0002635 ! normal protein ubiquitination intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071894 ! histone H2B conserved C-terminal lysine ubiquitination intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071894 ! histone H2B conserved C-terminal lysine ubiquitination relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-11-26T14:38:40Z [Term] id: FYPO:0002924 name: decreased cell population growth on maltose carbon source def: "A vegetative cell population growth phenotype in which cell growth is decreased relative to normal in a medium containing maltose as the carbon source." [PomBase:mah] comment: Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "decreased growth on maltose carbon source" BROAD [PomBase:mah] synonym: "decreased vegetative cell growth on maltose carbon source" EXACT [PomBase:mah] synonym: "growth defects, growth inhibition in maltose-based medium" RELATED [PomBase:mah] synonym: "reduced cell growth on maltose carbon source" EXACT [PomBase:mah] synonym: "slow cell growth on maltose carbon source" NARROW [PomBase:mah] is_a: FYPO:0001355 ! decreased vegetative cell population growth intersection_of: FYPO:0000046 ! decreased cell population growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:17306 ! maltose relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:17306 ! maltose created_by: midori creation_date: 2013-11-26T14:46:01Z [Term] id: FYPO:0002925 name: decreased protein localization to M26 site def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to an M26 site in a chromosome is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to M26 site" EXACT [PomBase:mah] synonym: "decreased protein localization to M26 binding site" EXACT [PomBase:mah, SO:0001900] synonym: "decreased protein localization to M26 site during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to M26 site during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to M26 site" EXACT [PomBase:mah] is_a: FYPO:0002839 ! decreased protein localization to chromosome intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034502 ! protein localization to chromosome intersection_of: occurs_at SO:0001900 ! M26_binding_site relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034502 ! protein localization to chromosome relationship: occurs_at SO:0001900 ! M26_binding_site created_by: midori creation_date: 2013-11-26T14:50:00Z [Term] id: FYPO:0002926 name: abolished poly(A) RNA binding def: "A molecular function phenotype in which polyadenylated RNA (poly(A) RNA) binding by a gene product does not occur, when a gene or the bound RNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "abolished polyA RNA binding" EXACT [PomBase:mah] synonym: "abolished polyadenylated RNA binding" EXACT [PomBase:mah] synonym: "poly(A) RNA binding abolished" EXACT [PomBase:mah] is_a: FYPO:0002133 ! abolished RNA binding intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0008143 ! poly(A) binding relationship: towards GO:0008143 ! poly(A) binding created_by: midori creation_date: 2013-11-27T15:14:30Z [Term] id: FYPO:0002927 name: decreased poly(A) RNA binding def: "A molecular function phenotype in which occurrence of polyadenylated RNA (poly(A) RNA) binding by a gene product is decreased, when a gene or the bound RNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "decreased polyA RNA binding" EXACT [PomBase:mah] synonym: "decreased polyadenylated RNA binding" EXACT [PomBase:mah] synonym: "reduced poly(A) RNA binding" EXACT [PomBase:mah] is_a: FYPO:0002134 ! decreased RNA binding intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0008143 ! poly(A) binding relationship: inheres_in GO:0008143 ! poly(A) binding created_by: midori creation_date: 2013-11-27T15:14:36Z [Term] id: FYPO:0002928 name: normal poly(A) tail length def: "A phenotype in which polyadenylated RNA molecules have poly(A) tails of normal (i.e. indistinguishable from wild type) length." [PMID:24081329, PomBase:mah] synonym: "normal polyA sequence length" EXACT [SO:0000610] synonym: "normal polyA tail length" EXACT [SO:0000610] is_a: FYPO:0000257 ! normal phenotype is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length intersection_of: inheres_in SO:0000610 ! polyA_sequence intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in SO:0000610 ! polyA_sequence relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-11-27T15:54:51Z [Term] id: FYPO:0002929 name: abnormal poly(A) tail length def: "A phenotype in which polyadenylated RNA molecules have poly(A) tails of abnormal length." [PMID:24081329, PomBase:mah] synonym: "abnormal polyA sequence length" EXACT [SO:0000610] synonym: "abnormal polyA tail length" EXACT [SO:0000610] is_a: FYPO:0001985 ! abnormal phenotype is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length intersection_of: inheres_in SO:0000610 ! polyA_sequence intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in SO:0000610 ! polyA_sequence relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-11-27T15:56:57Z [Term] id: FYPO:0002930 name: decreased poly(A) tail length def: "A phenotype in which polyadenylated RNA molecules have poly(A) tails of that are shorter than normal." [PomBase:mah] synonym: "decreased polyA sequence length" EXACT [SO:0000610] synonym: "decreased polyA tail length" EXACT [SO:0000610] synonym: "reduced poly(A) tail length" EXACT [PomBase:mah] synonym: "short poly(a) tails" EXACT [PomBase:mah] is_a: FYPO:0002929 ! abnormal poly(A) tail length is_a: PATO:0000574 ! decreased length intersection_of: PATO:0000574 ! decreased length intersection_of: inheres_in SO:0000610 ! polyA_sequence relationship: inheres_in SO:0000610 ! polyA_sequence created_by: midori creation_date: 2013-11-27T15:57:38Z [Term] id: FYPO:0002931 name: increased poly(A) tail length def: "A phenotype in which polyadenylated RNA molecules have poly(A) tails of that are longer than normal." [PomBase:mah] synonym: "increased polyA sequence length" EXACT [SO:0000610] synonym: "increased polyA tail length" EXACT [SO:0000610] synonym: "long poly(a) tails" EXACT [PomBase:mah] is_a: FYPO:0002929 ! abnormal poly(A) tail length is_a: PATO:0000573 ! increased length intersection_of: PATO:0000573 ! increased length intersection_of: inheres_in SO:0000610 ! polyA_sequence relationship: inheres_in SO:0000610 ! polyA_sequence created_by: midori creation_date: 2013-11-27T15:58:41Z [Term] id: FYPO:0002932 name: decreased snoRNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of mature snoRNA measured in a cell is lower than normal." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased mature snoRNA level" EXACT [PomBase:mah] synonym: "decreased small nucleolar RNA level" EXACT [PomBase:mah] synonym: "decreased snoRNA accumulation" RELATED [PomBase:mah] synonym: "decreased snoRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased snoRNA level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased snoRNA transcript level" BROAD [PomBase:vw] synonym: "reduced snoRNA level" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards SO:0000275 ! snoRNA relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards SO:0000275 ! snoRNA created_by: midori creation_date: 2013-11-28T13:13:18Z [Term] id: FYPO:0002933 name: increased snoRNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of mature snoRNA measured in a cell is higher than normal." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased mature snoRNA level" EXACT [PomBase:mah] synonym: "increased small nucleolar RNA level" EXACT [PomBase:mah] synonym: "increased snoRNA accumulation" RELATED [PomBase:mah] synonym: "increased snoRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased snoRNA level during vegetative growth" EXACT [PomBase:mah] synonym: "increased snoRNA transcript level" BROAD [PomBase:vw] is_a: FYPO:0000825 ! increased RNA level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards SO:0000275 ! snoRNA relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards SO:0000275 ! snoRNA created_by: midori creation_date: 2013-11-28T13:16:00Z [Term] id: FYPO:0002934 name: altered mRNA level during vegetative growth def: "A cell phenotype in which the amount of messenger RNA (mRNA) measured in a cell differs from normal when the cell is in the vegetative growth phase of the life cycle. Total mRNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "abnormal mRNA level during vegetative growth" EXACT [PomBase:mah] synonym: "altered cellular messenger RNA level during vegetative growth" EXACT [PomBase:mah] synonym: "altered cellular mRNA level during vegetative growth" EXACT [PomBase:mah] synonym: "altered mRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "altered mRNA transcript level during vegetative growth" EXACT [PomBase:vw] is_a: FYPO:0001326 ! altered RNA level during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards SO:0000234 ! mRNA relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000460 ! abnormal relationship: towards SO:0000234 ! mRNA created_by: midori creation_date: 2013-11-28T14:30:04Z [Term] id: FYPO:0002935 name: decreased mRNA level during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of messenger RNA (mRNA) measured in a cell is lower than normal. Total mRNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased cellular mRNA level during vegetative growth" EXACT [PomBase:vw] synonym: "decreased messenger RNA level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased mRNA accumulation during vegetative growth" RELATED [PomBase:mah] synonym: "decreased mRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased mRNA transcript level during vegetative growth" EXACT [PomBase:vw] synonym: "reduced mRNA level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth is_a: FYPO:0002934 ! altered mRNA level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards SO:0000234 ! mRNA relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards SO:0000234 ! mRNA created_by: midori creation_date: 2013-11-28T14:32:25Z [Term] id: FYPO:0002936 name: increased mRNA level during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of messenger RNA (mRNA) measured in a cell is higher than normal. Total mRNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased cellular mRNA level during vegetative growth" EXACT [PomBase:vw] synonym: "increased messenger RNA level during vegetative growth" EXACT [PomBase:mah] synonym: "increased mRNA accumulation during vegetative growth" RELATED [PomBase:mah] synonym: "increased mRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased mRNA transcript level during vegetative growth" EXACT [PomBase:vw] is_a: FYPO:0000825 ! increased RNA level during vegetative growth is_a: FYPO:0002934 ! altered mRNA level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards SO:0000234 ! mRNA relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards SO:0000234 ! mRNA created_by: midori creation_date: 2013-11-28T14:35:19Z [Term] id: FYPO:0002937 name: decreased pre-mRNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of any unspliced or incompletely spliced mRNA precursor measured in a cell is lower than normal." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased accumulation of pre-mRNA transcripts" RELATED [PomBase:vw] synonym: "decreased pre-mRNA accumulation" RELATED [PomBase:mah] synonym: "decreased pre-mRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased pre-mRNA level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased pre-mRNA transcript level" EXACT [PomBase:vw] synonym: "reduced pre-mRNA level" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth created_by: midori creation_date: 2013-11-28T14:38:47Z [Term] id: FYPO:0002938 name: normal mRNA level during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of messenger RNA (mRNA) measured in a cell is normal (i.e. indistinguishable from wild type). Total mRNA or a specific mRNA may be measured." [PomBase:mah] comment: We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "normal mRNA accumulation" RELATED [PomBase:mah] synonym: "normal mRNA level during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001317 ! normal RNA level during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards SO:0000234 ! mRNA relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards SO:0000234 ! mRNA created_by: midori creation_date: 2013-11-28T14:40:53Z [Term] id: FYPO:0002939 name: normal nuclear mRNA catabolic process def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which an RNA catabolic process that degrades mRNA encoded in the nucleus is normal (i.e. indistinguishable from wild type)." [GO:0000956, PomBase:mah] synonym: "normal nuclear mRNA breakdown" EXACT [GO:0000956] synonym: "normal nuclear mRNA catabolic process during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal nuclear mRNA catabolic process during vegetative growth" EXACT [PomBase:mah] synonym: "normal nuclear mRNA catabolism" EXACT [GO:0000956] synonym: "normal nuclear mRNA degradation" EXACT [GO:0000956] synonym: "normal nuclear-transcribed mRNA catabolic process" EXACT [GO:0000956] is_a: FYPO:0000859 ! normal metabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000956 ! nuclear-transcribed mRNA catabolic process intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000956 ! nuclear-transcribed mRNA catabolic process relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-11-28T14:42:41Z [Term] id: FYPO:0002940 name: normal growth on micafungin def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing micafungin." [PomBase:mah] synonym: "normal cell population growth in presence of micafungin" EXACT [PomBase:mah] synonym: "normal cell population growth on micafungin" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to caspofungin" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on caspofungin" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:600520 ! micafungin relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:600520 ! micafungin created_by: midori creation_date: 2013-12-04T13:04:57Z [Term] id: FYPO:0002941 name: swollen spheroid cell def: "A cell morphology phenotype in which a cell is shaped in the form of a spheroid, and has a larger volume than normal. In a swollen cell, both length and diameter are greater than normal, although the cell is only considered elongated if the length:width ratio is also greater than normal. In spheroid cells, there is much less difference between the long and short axes of the cell than in wild type. Spheroid cells may shorter than normal, with approximately the same diameter as normal, or they may be enlarged." [PomBase:mah] synonym: "enlarged spheroid cell" RELATED [PomBase:mah] synonym: "enlarged volume spheroid cell" EXACT [PomBase:mah] synonym: "large spheroid cell" RELATED [PomBase:vw] synonym: "spheroid cell with increased cell size" RELATED [PomBase:vw] synonym: "spheroid cell with increased cell volume" EXACT [PomBase:mah] synonym: "swollen rounded cell" EXACT [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: has_part FYPO:0000025 ! swollen cell intersection_of: has_part FYPO:0001955 ! spheroid cell relationship: has_part FYPO:0000025 ! swollen cell relationship: has_part FYPO:0001955 ! spheroid cell created_by: midori creation_date: 2013-12-04T13:30:22Z [Term] id: FYPO:0002942 name: swollen spheroid cell during G0 def: "A cell morphology phenotype in which a cell is shaped in the form of a spheroid, and has a larger volume than normal, when the cell is in G0 phase. In spheroid cells, there is much less difference between the long and short axes of the cell than in wild type. Spheroid cells may shorter than normal, with approximately the same diameter as normal, or they may be enlarged." [PomBase:mah] comment: Note that fission yeast cells can enter G0 as a result of either glucose starvation or nitrogen starvation, which can be specified in annotations using conditions. synonym: "enlarged spheroid cell during G0" RELATED [PomBase:mah] synonym: "enlarged volume spheroid cell during G0" EXACT [PomBase:mah] synonym: "large spheroid cell during G0" RELATED [PomBase:vw] synonym: "spheroid cell with increased cell size during G0" RELATED [PomBase:vw] synonym: "spheroid cell with increased cell volume during G0" EXACT [PomBase:mah] synonym: "swollen rounded cell during G0" EXACT [PomBase:mah] synonym: "swollen spheroid cell during cell quiescence" EXACT [PomBase:mah] synonym: "swollen spheroid cell during quiescence" EXACT [PomBase:mah] is_a: FYPO:0002941 ! swollen spheroid cell created_by: midori creation_date: 2013-12-04T14:15:58Z [Term] id: FYPO:0002943 name: swollen spheroid cell during G0 to G1 transition def: "A cell morphology phenotype in which a cell is shaped in the form of a spheroid, and has a larger volume than normal, when the cell undergoes transition from G0 phase to G1. In spheroid cells, there is much less difference between the long and short axes of the cell than in wild type. Spheroid cells may shorter than normal, with approximately the same diameter as normal, or they may be enlarged." [PomBase:mah] comment: Note that fission yeast cells can enter G0 as a result of either glucose starvation or nitrogen starvation, which can be specified in annotations using conditions. synonym: "enlarged spheroid cell during G0 to G1 transition" RELATED [PomBase:mah] synonym: "enlarged volume spheroid cell during G0 to G1 transition" EXACT [PomBase:mah] synonym: "large spheroid cell during G0 to G1 transition" RELATED [PomBase:vw] synonym: "spheroid cell with increased cell size during G0 to G1 transition" RELATED [PomBase:vw] synonym: "spheroid cell with increased cell volume during G0 to G1 transition" EXACT [PomBase:mah] synonym: "swollen rounded cell during G0 to G1 transition" EXACT [PomBase:mah] synonym: "swollen spheroid cell during cell cycle re-entry" EXACT [PomBase:mah] synonym: "swollen spheroid cell during cell quiescence to G1 transition" EXACT [PomBase:mah] synonym: "swollen spheroid cell during exit from cell quiescence" EXACT [PomBase:mah] synonym: "swollen spheroid cell during quiescence to G1 transition" EXACT [PomBase:mah] is_a: FYPO:0002941 ! swollen spheroid cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0045023 ! G0 to G1 transition intersection_of: has_part FYPO:0000025 ! swollen cell intersection_of: has_part FYPO:0001955 ! spheroid cell relationship: exists_during GO:0045023 ! G0 to G1 transition relationship: has_part FYPO:0000025 ! swollen cell relationship: has_part FYPO:0001955 ! spheroid cell created_by: midori creation_date: 2013-12-04T14:18:36Z [Term] id: FYPO:0002944 name: decreased RNA level during G0 def: "A cell phenotype in which the amount of RNA measured in a cell is lower than normal when the cell is in G0 phase. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased RNA accumulation during G0" RELATED [PomBase:mah] synonym: "decreased RNA level during cell quiescence" EXACT [PomBase:mah] synonym: "decreased transcript level during G0" EXACT [PomBase:vw] synonym: "reduced RNA level during G0" EXACT [PomBase:mah] is_a: FYPO:0000826 ! decreased RNA level is_a: FYPO:0003864 ! decreased level of substance in cell during G0 intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0044838 ! cell quiescence intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0044838 ! cell quiescence relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2013-12-04T14:27:54Z [Term] id: FYPO:0002945 name: increased RNA level during G0 def: "A cell phenotype in which the amount of RNA measured in a cell when the cell is in G0 phase is higher than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased RNA accumulation during G0" RELATED [PomBase:mah] synonym: "increased RNA level during cell quiescence" EXACT [PomBase:mah] synonym: "increased transcript level during G0" EXACT [PomBase:vw] is_a: FYPO:0000824 ! altered RNA level is_a: FYPO:0002949 ! increased level of substance in cell during G0 intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0044838 ! cell quiescence intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0044838 ! cell quiescence relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2013-12-04T14:29:02Z [Term] id: FYPO:0002946 name: abnormal cell wall def: "A physical cellular phenotype in which the cell wall is abnormal." [PomBase:mah] synonym: "cell wall defects" EXACT [PomBase:mah] is_a: FYPO:0000287 ! abnormal subcellular component intersection_of: PATO:0001241 ! physical object quality intersection_of: inheres_in GO:0009277 ! fungal-type cell wall intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0009277 ! fungal-type cell wall relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-12-04T14:32:50Z [Term] id: FYPO:0002947 name: abnormal cell wall morphology def: "A physical cellular phenotype in which the size, shape, or structure of the fungal-type cell wall is abnormal." [PomBase:mah] synonym: "cell wall morphology: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0002946 ! abnormal cell wall is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: inheres_in GO:0009277 ! fungal-type cell wall intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0009277 ! fungal-type cell wall relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-12-04T14:36:38Z [Term] id: FYPO:0002948 name: delaminated cell wall def: "A physical cellular phenotype in which the fungal-type cell wall is delaminated, i.e. one or more of its layers peels off." [PomBase:al, PomBase:mah] synonym: "delaminate cell wall" EXACT [PomBase:mah] is_a: FYPO:0002947 ! abnormal cell wall morphology is_a: PATO:0001514 ! delaminated intersection_of: PATO:0001514 ! delaminated intersection_of: inheres_in GO:0009277 ! fungal-type cell wall relationship: inheres_in GO:0009277 ! fungal-type cell wall created_by: midori creation_date: 2013-12-04T14:37:13Z [Term] id: FYPO:0002949 name: increased level of substance in cell during G0 def: "A cell phenotype in which the amount a specific substance measured in a cell is higher than normal when the cell is in G0 phase." [PomBase:mah] synonym: "increased accumulation of substance in cell during G0" RELATED [PomBase:mah] synonym: "increased level of substance in cell during cell quiescence" EXACT [PomBase:mah] synonym: "increased substance level during G0" EXACT [PomBase:vw] is_a: FYPO:0000990 ! increased level of substance in cell intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0044838 ! cell quiescence intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:24431 ! chemical entity relationship: exists_during GO:0044838 ! cell quiescence relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:24431 ! chemical entity created_by: midori creation_date: 2013-12-04T14:41:57Z [Term] id: FYPO:0002950 name: increased N-acetyl-D-glucosaminate level during G0 def: "A cell phenotype in which the amount of N-acetyl-D-glucosaminate measured in a cell is lower than normal when the cell is in G0 phase." [PomBase:mah] synonym: "increased N-acetyl-D-glucosaminate accumulation during G0" RELATED [PomBase:mah] synonym: "increased N-acetyl-D-glucosaminate level during cell quiescence" EXACT [PomBase:mah] is_a: FYPO:0002949 ! increased level of substance in cell during G0 intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0044838 ! cell quiescence intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:38439 ! N-acetyl-D-glucosaminate relationship: exists_during GO:0044838 ! cell quiescence relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:38439 ! N-acetyl-D-glucosaminate created_by: midori creation_date: 2013-12-04T14:44:23Z [Term] id: FYPO:0002951 name: increased L-ergothioneine level during G0 def: "A cell phenotype in which the amount of L-ergothioneine measured in a cell is lower than normal when the cell is in G0 phase." [PomBase:mah] synonym: "increased ergothioneine level during G0" EXACT [CHEBI:4828] synonym: "increased L-ergothioneine accumulation during G0" RELATED [PomBase:mah] synonym: "increased L-ergothioneine level during cell quiescence" EXACT [PomBase:mah] is_a: FYPO:0002949 ! increased level of substance in cell during G0 intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0044838 ! cell quiescence intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:4828 ! ergothioneine relationship: exists_during GO:0044838 ! cell quiescence relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:4828 ! ergothioneine created_by: midori creation_date: 2013-12-04T14:47:32Z [Term] id: FYPO:0002952 name: increased S-methyl-L-ergothioneine level during G0 def: "A cell phenotype in which the amount of S-methyl-L-ergothioneine measured in a cell is lower than normal when the cell is in G0 phase." [PomBase:mah] synonym: "increased S-methyl-L-ergothioneine accumulation during G0" RELATED [PomBase:mah] synonym: "increased S-methyl-L-ergothioneine level during cell quiescence" EXACT [PomBase:mah] is_a: FYPO:0002949 ! increased level of substance in cell during G0 intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0044838 ! cell quiescence intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:76620 ! S-methyl-L-ergothioneine relationship: exists_during GO:0044838 ! cell quiescence relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:76620 ! S-methyl-L-ergothioneine created_by: midori creation_date: 2013-12-04T14:48:39Z [Term] id: FYPO:0002953 name: increased S-adenosyl-L-methionine level during G0 def: "A cell phenotype in which the amount of S-adenosyl-L-methionine measured in a cell is lower than normal when the cell is in G0 phase." [PomBase:mah] synonym: "increased S-adenosyl-L-methionine accumulation during G0" RELATED [PomBase:mah] synonym: "increased S-adenosyl-L-methionine level during cell quiescence" EXACT [PomBase:mah] synonym: "increased S-adenosylmethionine level during G0" EXACT [CHEBI:15414] synonym: "increased SAM level during G0" EXACT [PomBase:mah] is_a: FYPO:0002949 ! increased level of substance in cell during G0 intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0044838 ! cell quiescence intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:15414 ! S-adenosyl-L-methionine relationship: exists_during GO:0044838 ! cell quiescence relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:15414 ! S-adenosyl-L-methionine created_by: midori creation_date: 2013-12-04T14:51:09Z [Term] id: FYPO:0002954 name: increased S-adenosyl-3-thiopropylamine level during G0 def: "A cell phenotype in which the amount of S-adenosyl-3-thiopropylamine measured in a cell is lower than normal when the cell is in G0 phase." [PomBase:mah] synonym: "increased S-adenosyl-3-thiopropylamine accumulation during G0" RELATED [PomBase:mah] synonym: "increased S-adenosyl-3-thiopropylamine level during cell quiescence" EXACT [PomBase:mah] is_a: FYPO:0002949 ! increased level of substance in cell during G0 intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0044838 ! cell quiescence intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:79030 ! S-adenosyl-3-thiopropylamine relationship: exists_during GO:0044838 ! cell quiescence relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:79030 ! S-adenosyl-3-thiopropylamine created_by: midori creation_date: 2013-12-04T14:52:31Z [Term] id: FYPO:0002955 name: abnormal G0 to G1 transition def: "A cellular process phenotype in which the transition from G0 phase (quiescence) to G1 is abnormal." [PomBase:mah] synonym: "abnormal exit from cell quiescence" EXACT [PomBase:mah] is_a: FYPO:0002734 ! abnormal cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0045023 ! G0 to G1 transition intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0045023 ! G0 to G1 transition relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-12-04T14:59:49Z [Term] id: FYPO:0002956 name: abnormal protein localization to nucleus def: "A cell phenotype in which the localization of a protein to the nucleus is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found in the nucleus and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to nucleus" EXACT [GO:0034504, PomBase:mah] is_a: FYPO:0001370 ! abnormal protein localization intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0034504 ! protein localization to nucleus intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0034504 ! protein localization to nucleus relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-12-04T15:47:25Z [Term] id: FYPO:0002957 name: abnormal protein localization to nucleus during meiosis def: "A cell phenotype in which the localization of a protein to the nucleus is abnormal during one or both meiotic nuclear divisions." [PomBase:mah] comment: Encompasses both presence of proteins not normally found in the nucleus and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to nucleus during meiosis" EXACT [GO:0034504, PomBase:mah] synonym: "abnormal protein localization to nucleus during meiotic nuclear division" EXACT [GO:0007126] is_a: FYPO:0002956 ! abnormal protein localization to nucleus is_a: FYPO:0003549 ! abnormal protein localization during meiosis intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0007126 ! meiotic nuclear division intersection_of: inheres_in_part_of GO:0034504 ! protein localization to nucleus intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0007126 ! meiotic nuclear division relationship: inheres_in_part_of GO:0034504 ! protein localization to nucleus relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-12-04T15:48:42Z [Term] id: FYPO:0002958 name: abnormal protein localization to Mei2 nuclear dot def: "A cell phenotype in which the localization of a protein to the Mei2 nuclear dot is abnormal. The Mei2 nuclear dot is a nuclear body that contains Mei2, other proteins, and meiRNA, and forms during meiotic prophase in a fixed position in the horsetail nucleus." [GO:0033620, PomBase:mah] comment: Encompasses both presence of proteins not normally found at the Mei2 nuclear dot and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to Mei2 nuclear dot" EXACT [PomBase:mah] is_a: FYPO:0002957 ! abnormal protein localization to nucleus during meiosis intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:1902549 ! protein localization to Mei2 nuclear dot intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:1902549 ! protein localization to Mei2 nuclear dot relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-12-04T15:52:20Z [Term] id: FYPO:0002959 name: decreased RNA level during meiosis def: "A cell phenotype in which the amount of RNA measured in a cell is lower than normal during one or both meiotic nuclear divisions. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased RNA accumulation during meiosis" RELATED [PomBase:mah] synonym: "decreased RNA level during meiotic nuclear division" EXACT [GO:0007126] synonym: "decreased transcript level during meiosis" EXACT [PomBase:vw] synonym: "reduced RNA level during meiosis" EXACT [PomBase:mah] is_a: FYPO:0004630 ! decreased RNA level during meiotic cell cycle intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0007126 ! meiotic nuclear division intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0007126 ! meiotic nuclear division relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2013-12-04T15:55:26Z [Term] id: FYPO:0002960 name: increased level of DSR-containing meiosis gene RNA during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more RNAs that are normally expressed during meiosis, and that contain determinant of selective removal (DSR) sequences, measured in a cell is higher than normal (i.e. higher than observed in wild-type cells during vegetative growth)." [PMID:23980030, PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "increased DSR-containing meiosis gene RNA accumulation during vegetative growth" RELATED [PomBase:mah] synonym: "increased level of DSR-containing meiosis gene RNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased level of DSR-containing meiosis gene transcripts during vegetative growth" EXACT [PomBase:vw] is_a: FYPO:0002173 ! increased level of meiosis gene RNA during vegetative growth created_by: midori creation_date: 2013-12-04T15:56:39Z [Term] id: FYPO:0002961 name: delaminated cell wall during G0 def: "A physical cellular phenotype in which the fungal-type cell wall is delaminated, i.e. one or more of its layers peels off, when the cell is in G0 phase." [PomBase:al, PomBase:mah] synonym: "delaminate cell wall during G0" EXACT [PomBase:mah] synonym: "delaminated cell wall during cell quiescence" EXACT [PomBase:mah] synonym: "delaminated cell wall during G0" RELATED [PomBase:mah] is_a: FYPO:0002948 ! delaminated cell wall intersection_of: PATO:0001514 ! delaminated intersection_of: exists_during GO:0044838 ! cell quiescence intersection_of: inheres_in GO:0009277 ! fungal-type cell wall relationship: exists_during GO:0044838 ! cell quiescence relationship: inheres_in GO:0009277 ! fungal-type cell wall created_by: midori creation_date: 2013-12-04T14:37:13Z [Term] id: FYPO:0002962 name: abolished protein localization to Mei2 nuclear dot def: "A cell phenotype in which the localization of a protein to the Mei2 nuclear dot is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "protein localisation to Mei2 nuclear dot abolished" EXACT [PomBase:mah] synonym: "protein localization to Mei2 nuclear dot abolished" EXACT [PomBase:mah] is_a: FYPO:0002958 ! abnormal protein localization to Mei2 nuclear dot is_a: FYPO:0003450 ! abolished protein localization to nucleus intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:1902549 ! protein localization to Mei2 nuclear dot relationship: towards GO:1902549 ! protein localization to Mei2 nuclear dot created_by: midori creation_date: 2013-12-10T11:56:13Z [Term] id: FYPO:0002963 name: abnormal protein localization to Mmi1 focus def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to Mmi1 foci is abnormal. Mmi1 foci are small structure that form within the nucleus, and contain proteins involved in degrading meiosis-specific RNAs during the mitotic cell cycle, such as Mmi1, Iss10, and Red1." [PMID:23980030, PomBase:mah] comment: Encompasses both presence of proteins not normally found associated with chromatin and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to Mmi1 focus" EXACT [PomBase:mah] synonym: "abnormal protein localization to Mmi1 foci" EXACT [PomBase:mah] synonym: "abnormal protein localization to Mmi1 focus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein localization to Mmi1 focus during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal protein localization to Mmi1 nuclear focus complex" EXACT [GO:1990251] is_a: FYPO:0001129 ! abnormal protein localization to nucleus during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1902666 ! protein localization to Mmi1 nuclear focus complex intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1902666 ! protein localization to Mmi1 nuclear focus complex relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2013-12-10T11:59:35Z [Term] id: FYPO:0002964 name: increased protein localization to Mmi1 focus def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to Mmi1 foci is increased. Mmi1 foci are small structure that form within the nucleus, and contain proteins involved in degrading meiosis-specific RNAs during the mitotic cell cycle, such as Mmi1, Iss10, and Red1." [PMID:23980030, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to Mmi1 focus" EXACT [PomBase:mah] synonym: "increased protein localization to Mmi1 foci" EXACT [PomBase:mah] synonym: "increased protein localization to Mmi1 focus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein localization to Mmi1 focus during vegetative growth" EXACT [PomBase:mah] synonym: "increased protein localization to Mmi1 nuclear focus complex" EXACT [GO:1990251] is_a: FYPO:0001130 ! increased protein localization to nucleus during vegetative growth is_a: FYPO:0002963 ! abnormal protein localization to Mmi1 focus intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902666 ! protein localization to Mmi1 nuclear focus complex relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902666 ! protein localization to Mmi1 nuclear focus complex created_by: midori creation_date: 2013-12-10T11:59:52Z [Term] id: FYPO:0002965 name: normal protein localization to nucleolus def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleolus is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to nucleolus" EXACT [PomBase:mah] synonym: "normal protein localization to nucleolus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to nucleolus during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000838 ! normal protein localization to nucleus intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902570 ! protein localization to nucleolus intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902570 ! protein localization to nucleolus relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-12-10T12:26:53Z [Term] id: FYPO:0002966 name: normal protein localization to mitotic spindle def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the mitotic spindle is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to mitotic spindle" EXACT [PomBase:mah] synonym: "normal protein localization to mitotic spindle during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003184 ! normal protein localization to cytoskeleton during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902480 ! protein localization to mitotic spindle intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902480 ! protein localization to mitotic spindle relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-12-10T12:28:10Z [Term] id: FYPO:0002967 name: normal protein localization to mitotic spindle pole body def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the mitotic spindle pole body is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to mitotic spindle pole body" EXACT [PomBase:mah] synonym: "normal protein localization to mitotic SPB" EXACT [PomBase:mah] synonym: "normal protein localization to spindle pole body during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to spindle pole body during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001836 ! normal protein localization to spindle pole body is_a: FYPO:0002966 ! normal protein localization to mitotic spindle intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902440 ! protein localization to mitotic spindle pole body intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902440 ! protein localization to mitotic spindle pole body relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-12-10T12:30:11Z [Term] id: FYPO:0002968 name: normal protein localization to mitotic spindle pole body during G2 def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the mitotic spindle pole body is normal (i.e. indistinguishable from wild type) during G2 phase of the cell cycle." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to mitotic spindle pole body during G2" EXACT [PomBase:mah] synonym: "normal protein localization to mitotic SPB during G2" EXACT [PomBase:mah] synonym: "normal protein localization to spindle pole body during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002967 ! normal protein localization to mitotic spindle pole body intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0000085 ! mitotic G2 phase intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902440 ! protein localization to mitotic spindle pole body intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0000085 ! mitotic G2 phase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902440 ! protein localization to mitotic spindle pole body relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-12-10T12:31:29Z [Term] id: FYPO:0002969 name: increased protein localization to mitotic spindle pole body def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the mitotic spindle pole body is increased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to mitotic spindle pole body" EXACT [PomBase:mah] synonym: "increased protein localization to mitotic SPB" EXACT [PomBase:mah] synonym: "increased protein localization to spindle pole body during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000939 ! abnormal protein localization to mitotic spindle pole body is_a: FYPO:0004635 ! increased protein localization to mitotic spindle intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902440 ! protein localization to mitotic spindle pole body relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902440 ! protein localization to mitotic spindle pole body created_by: midori creation_date: 2013-12-10T12:32:39Z [Term] id: FYPO:0002970 name: increased protein localization to mitotic spindle pole body during metaphase def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the mitotic spindle pole body is increased during metaphase." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to mitotic spindle pole body during metaphase" EXACT [PomBase:mah] synonym: "increased protein localization to mitotic SPB during metaphase" EXACT [PomBase:mah] synonym: "increased protein localization to mitotic spindle pole body during mitotic metaphase" EXACT [PomBase:mah] synonym: "increased protein localization to spindle pole body during metaphase during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002969 ! increased protein localization to mitotic spindle pole body intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0000089 ! mitotic metaphase intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902440 ! protein localization to mitotic spindle pole body relationship: happens_during GO:0000089 ! mitotic metaphase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902440 ! protein localization to mitotic spindle pole body created_by: midori creation_date: 2013-12-10T12:33:13Z [Term] id: FYPO:0002971 name: decreased protein localization to mitotic spindle pole body during telophase def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the mitotic spindle pole body is decreased during telophase." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to mitotic spindle pole body during telophase" EXACT [PomBase:mah] synonym: "decreased protein localization to mitotic SPB during telophase" EXACT [PomBase:mah] synonym: "decreased protein localization to mitotic spindle pole body during mitotic telophase" EXACT [PomBase:mah] synonym: "decreased protein localization to spindle pole body during telophase during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to mitotic spindle pole body during telophase" EXACT [PomBase:mah] is_a: FYPO:0000940 ! decreased protein localization to mitotic spindle pole body intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0000093 ! mitotic telophase intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902440 ! protein localization to mitotic spindle pole body relationship: happens_during GO:0000093 ! mitotic telophase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902440 ! protein localization to mitotic spindle pole body created_by: midori creation_date: 2013-12-10T12:34:01Z [Term] id: FYPO:0002972 name: increased ubiquitin ligase activity def: "A molecular function phenotype in which the observed rate of ubiquitin ligase activity is increased." [PomBase:mah] synonym: "increased ubiquitin-protein ligase activity" EXACT [GO:0004842] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0001912 ! abnormal ubiquitin ligase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0004842 ! ubiquitin-protein transferase activity relationship: inheres_in GO:0004842 ! ubiquitin-protein transferase activity created_by: midori creation_date: 2013-12-10T12:35:59Z [Term] id: FYPO:0002973 name: increased ubiquitin ligase activity during mitotic metaphase def: "A molecular function phenotype in which the observed rate of ubiquitin ligase activity is increased during metaphase of the mitotic cell cycle." [PomBase:mah] synonym: "increased ubiquitin ligase activity during metaphase of mitosis" EXACT [PomBase:mah] synonym: "increased ubiquitin-protein ligase activity during mitotic metaphase" EXACT [GO:0004842] is_a: FYPO:0002972 ! increased ubiquitin ligase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: during GO:0000089 ! mitotic metaphase intersection_of: inheres_in GO:0004842 ! ubiquitin-protein transferase activity relationship: during GO:0000089 ! mitotic metaphase relationship: inheres_in GO:0004842 ! ubiquitin-protein transferase activity created_by: midori creation_date: 2013-12-10T12:36:59Z [Term] id: FYPO:0002974 name: normal origin recognition complex assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which origin recognition complex (ORC) assembly is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal ORC assembly" EXACT [GO:1902561] synonym: "normal origin recognition complex assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal origin recognition complex assembly during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001215 ! normal protein complex assembly intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902561 ! origin recognition complex assembly intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902561 ! origin recognition complex assembly relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-12-10T12:42:55Z [Term] id: FYPO:0002975 name: decreased RNA level during cellular response to hydroxyurea def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to hydroxyurea is lower than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased RNA accumulation during cellular response to hydroxyurea" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to HU" EXACT [PomBase:mah] synonym: "decreased RNA level during cellular response to hydroxyurea during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to hydroxyurea during vegetative growth" EXACT [PomBase:mah] synonym: "decreased transcript level during cellular response to hydroxyurea" EXACT [PomBase:vw] synonym: "reduced RNA level during cellular response to hydroxyurea" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: exists_during GO:0072711 ! cellular response to hydroxyurea intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: exists_during GO:0072711 ! cellular response to hydroxyurea relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2013-12-10T14:52:35Z [Term] id: FYPO:0002976 name: decreased protein localization to chromatin at MCB promoters during cellular response to hydroxyurea def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to chromatin at promoters that contain MCB sites is decreased during a cellular response to hydroxyurea." [PMID:24006488, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to chromatin at MCB promoters during cellular response to hydroxyurea" EXACT [PomBase:mah] synonym: "decreased protein localization to chromatin at MCB promoters during cellular response to HU" EXACT [PomBase:mah] synonym: "decreased protein localization to chromatin at MCB promoters during cellular response to hydroxyurea during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to chromatin at MCB promoters during cellular response to hydroxyurea during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein localization to chromatin at MCB-containing promoters during cellular response to hydroxyurea" EXACT [PomBase:mah] synonym: "reduced protein localization to chromatin at MCB promoters during cellular response to hydroxyurea" EXACT [PomBase:mah] is_a: FYPO:0002909 ! decreased protein localization to chromatin during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: happens_during GO:0072711 ! cellular response to hydroxyurea intersection_of: inheres_in GO:0071168 ! protein localization to chromatin intersection_of: occurs_at SO:0001855 ! MCB relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: happens_during GO:0072711 ! cellular response to hydroxyurea relationship: inheres_in GO:0071168 ! protein localization to chromatin relationship: occurs_at SO:0001855 ! MCB created_by: midori creation_date: 2013-12-10T14:55:44Z [Term] id: FYPO:0002977 name: increased protein localization to chromatin at MCB promoters during cellular response to hydroxyurea def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to chromatin at promoters that contain MCB sites is increased during a cellular response to hydroxyurea." [PMID:24006488, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to chromatin at MCB promoters during cellular response to hydroxyurea" EXACT [PomBase:mah] synonym: "increased protein localization to chromatin at MCB promoters during cellular response to HU" EXACT [PomBase:mah] synonym: "increased protein localization to chromatin at MCB promoters during cellular response to hydroxyurea during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein localization to chromatin at MCB promoters during cellular response to hydroxyurea during vegetative growth" EXACT [PomBase:mah] synonym: "increased protein localization to chromatin at MCB-containing promoters during cellular response to hydroxyurea" EXACT [PomBase:mah] is_a: FYPO:0003011 ! increased protein localization to chromatin intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: happens_during GO:0072711 ! cellular response to hydroxyurea intersection_of: inheres_in GO:0071168 ! protein localization to chromatin intersection_of: occurs_at SO:0001855 ! MCB relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: happens_during GO:0072711 ! cellular response to hydroxyurea relationship: inheres_in GO:0071168 ! protein localization to chromatin relationship: occurs_at SO:0001855 ! MCB created_by: midori creation_date: 2013-12-10T14:58:33Z [Term] id: FYPO:0002978 name: increased protein localization to chromatin during cellular response to methyl methanesulfonate def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to chromatin is increased during a cellular response to methyl methanesulfonate." [PMID:24006488, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to chromatin during cellular response to methyl methanesulfonate" EXACT [PomBase:mah] synonym: "increased protein localization to chromatin during cellular response to methyl methanesulfonate during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein localization to chromatin during cellular response to methyl methanesulfonate during vegetative growth" EXACT [PomBase:mah] synonym: "increased protein localization to chromatin during cellular response to methyl methanesulphonate" EXACT [PomBase:mah] synonym: "increased protein localization to chromatin during cellular response to MMS" EXACT [PomBase:mah] is_a: FYPO:0003011 ! increased protein localization to chromatin intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: happens_during GO:0072703 ! cellular response to methyl methanesulfonate intersection_of: inheres_in GO:0071168 ! protein localization to chromatin relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: happens_during GO:0072703 ! cellular response to methyl methanesulfonate relationship: inheres_in GO:0071168 ! protein localization to chromatin created_by: midori creation_date: 2013-12-10T15:10:59Z [Term] id: FYPO:0002979 name: normal protein localization to chromatin during cellular response to methyl methanesulfonate def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to chromatin is normal (i.e. indistinguishable from wild type) during a cellular response to methyl methanesulfonate." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to chromatin during cellular response to methyl methanesulfonate" EXACT [PomBase:mah] synonym: "normal protein localization to chromatin during cellular response to methyl methanesulfonate during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to chromatin during cellular response to methyl methanesulfonate during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein localization to chromatin during cellular response to methyl methanesulphonate" EXACT [PomBase:mah] synonym: "normal protein localization to chromatin during cellular response to MMS" EXACT [PomBase:mah] is_a: FYPO:0001509 ! normal protein localization to chromatin intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: happens_during GO:0072703 ! cellular response to methyl methanesulfonate intersection_of: inheres_in GO:0071168 ! protein localization to chromatin intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: happens_during GO:0072703 ! cellular response to methyl methanesulfonate relationship: inheres_in GO:0071168 ! protein localization to chromatin relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-12-10T15:12:28Z [Term] id: FYPO:0002980 name: increased chromatin binding def: "A molecular function phenotype in which occurrence of chromatin binding by a gene product (usually a protein) in a mutant is increased. The affected gene product may be encoded by the mutated gene, or by a different gene, and may normally bind DNA, protein, or both in chromatin." [PomBase:mah] is_a: FYPO:0002576 ! abnormal chromatin binding is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0003682 ! chromatin binding relationship: inheres_in GO:0003682 ! chromatin binding created_by: midori creation_date: 2013-12-10T15:27:49Z [Term] id: FYPO:0002981 name: increased chromatin binding during cellular response to methyl methanesulfonate def: "A molecular function phenotype in which occurrence of chromatin binding by a gene product (usually a protein) in a mutant is increased during a cellular response to methyl methanesulfonate. The affected gene product may be encoded by the mutated gene, or by a different gene, and may normally bind DNA, protein, or both in chromatin." [PomBase:mah] synonym: "increased chromatin binding during cellular response to methyl methanesulphonate" EXACT [PomBase:mah] synonym: "increased chromatin binding during cellular response to MMS" EXACT [PomBase:mah] is_a: FYPO:0002980 ! increased chromatin binding intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072703 ! cellular response to methyl methanesulfonate intersection_of: inheres_in GO:0003682 ! chromatin binding relationship: happens_during GO:0072703 ! cellular response to methyl methanesulfonate relationship: inheres_in GO:0003682 ! chromatin binding created_by: midori creation_date: 2013-12-10T15:28:23Z [Term] id: FYPO:0002982 name: abolished protein serine phosphorylation during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of serine residues in one or more specific proteins, or of specific protein sites, does not occur." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished peptidyl-serine phosphorylation during vegetative growth" EXACT [GO:0018105] synonym: "abolished protein serine phosphorylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein serine phosphorylation abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002033 ! abolished protein phosphorylation during vegetative growth intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0018105 ! peptidyl-serine phosphorylation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0018105 ! peptidyl-serine phosphorylation created_by: midori creation_date: 2013-12-10T15:30:47Z [Term] id: FYPO:0002983 name: abolished protein serine phosphorylation during cellular response to DNA damage def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of serine residues in one or more specific proteins, or of specific protein sites, does not occur during a cellular response to DNA damage." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "protein serine phosphorylation abolished during cellular response to DNA damage" EXACT [PomBase:mah] is_a: FYPO:0002898 ! abolished protein phosphorylation during cellular response to DNA damage is_a: FYPO:0002982 ! abolished protein serine phosphorylation during vegetative growth intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0006974 ! cellular response to DNA damage stimulus intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0018105 ! peptidyl-serine phosphorylation relationship: during GO:0006974 ! cellular response to DNA damage stimulus relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0018105 ! peptidyl-serine phosphorylation created_by: midori creation_date: 2013-12-10T15:34:20Z [Term] id: FYPO:0002984 name: normal RNA level during cellular response to methyl methanesulfonate def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to methyl methanesulfonate is normal (i.e. indistinguishable from wild type). Total RNA or a specific RNA may be affected." [PomBase:mah] comment: We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "normal mRNA level during cellular response to methyl methanesulfonate" NARROW [PomBase:mah] synonym: "normal RNA accumulation during cellular response to methyl methanesulfonate" RELATED [PomBase:mah] synonym: "normal RNA level during cellular response to methyl methanesulfonate during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal RNA level during cellular response to methyl methanesulfonate during vegetative growth" EXACT [PomBase:mah] synonym: "normal RNA level during cellular response to methyl methanesulphonate" EXACT [PomBase:mah] synonym: "normal RNA level during cellular response to MMS" EXACT [PomBase:mah] is_a: FYPO:0001317 ! normal RNA level during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0071703 ! detection of organic substance intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0071703 ! detection of organic substance relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2013-12-10T15:37:29Z [Term] id: FYPO:0002985 name: increased RNA level during cellular response to methyl methanesulfonate def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to methyl methanesulfonate is higher than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased mRNA level during cellular response to methyl methanesulfonate" NARROW [PomBase:mah] synonym: "increased RNA accumulation during cellular response to methyl methanesulfonate" RELATED [PomBase:mah] synonym: "increased RNA level during cellular response to methyl methanesulfonate during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased RNA level during cellular response to methyl methanesulfonate during vegetative growth" EXACT [PomBase:mah] synonym: "increased RNA level during cellular response to methyl methanesulphonate" EXACT [PomBase:mah] synonym: "increased RNA level during cellular response to MMS" EXACT [PomBase:mah] synonym: "increased transcript level during cellular response to methyl methanesulfonate" EXACT [PomBase:vw] is_a: FYPO:0000825 ! increased RNA level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: exists_during GO:0072703 ! cellular response to methyl methanesulfonate intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: exists_during GO:0072703 ! cellular response to methyl methanesulfonate relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2013-12-10T15:38:51Z [Term] id: FYPO:0002986 name: increased chromatin binding during cellular response to ionizing radiation def: "A molecular function phenotype in which occurrence of chromatin binding by a gene product (usually a protein) in a mutant is increased during a cellular response to ionizing radiation. The affected gene product may be encoded by the mutated gene, or by a different gene, and may normally bind DNA, protein, or both in chromatin." [PomBase:mah] synonym: "increased chromatin binding during cellular response to IR" EXACT [PomBase:mah] is_a: FYPO:0002980 ! increased chromatin binding intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0071480 ! cellular response to gamma radiation intersection_of: inheres_in GO:0003682 ! chromatin binding relationship: happens_during GO:0071480 ! cellular response to gamma radiation relationship: inheres_in GO:0003682 ! chromatin binding created_by: midori creation_date: 2013-12-10T15:40:22Z [Term] id: FYPO:0002987 name: inviable after spore germination, without cell division, swollen cell with central constriction def: "A phenotype in which a spore germinates to produce an inviable cell that does not divide, has a larger diameter and volume than normal, and has an abnormal shape featuring a constriction at the center of the cell, corresponding to the cell division site. In some such cells, the diameter at the ends is much greater than in wild-type cells." [PomBase:mah] synonym: "essential; germinating spore, without cell division, swollen cell with central constriction" RELATED [PomBase:mah] synonym: "inviable after spore germination, undivided swollen cell with central constriction" EXACT [PomBase:mah] synonym: "inviable after spore germination, without cell division, swollen cell with constricted region at cell division site" EXACT [PomBase:vw] synonym: "inviable after spore germination, without cell division, swollen dumbbell-shaped cell" RELATED [PomBase:mah] synonym: "inviable following spore germination, without cell division, swollen cell with central constriction" EXACT [PomBase:mah] synonym: "inviable germinated spore, without cell division, swollen cell with central constriction" EXACT [PomBase:mah] is_a: FYPO:0001991 ! inviable after spore germination, without cell division created_by: midori creation_date: 2013-12-11T15:47:17Z [Term] id: FYPO:0002988 name: sensitive to ammonium def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to ammonium. Cells stop growing (and may die) at a concentration of ammonium that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to ammonium" EXACT [PomBase:mah] synonym: "sensitive to ammonium during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to ammonium during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to NH4+" RELATED [CHEBI:28938] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:28938 ! ammonium relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:28938 ! ammonium created_by: midori creation_date: 2013-12-11T15:54:16Z [Term] id: FYPO:0002989 name: increased level of transmembrane transport gene mRNA during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more iron transport messenger RNAs measured in a cell is higher than normal (i.e. higher than observed in wild-type cells). Iron transport m RNAs are transcribed from genes whose products are involved in iron transport." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "increased level of transmembrane transport gene mRNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased level of transmembrane transport gene transcripts during vegetative growth" EXACT [PomBase:vw] synonym: "increased mRNA level of genes involved in transmembrane transport during vegetative growth" EXACT [PomBase:al] synonym: "increased mRNA level of transmembrane transport genes during vegetative growth" EXACT [PomBase:al] synonym: "increased transmembrane transport gene mRNA accumulation during vegetative growth" RELATED [PomBase:mah] is_a: FYPO:0000825 ! increased RNA level during vegetative growth created_by: midori creation_date: 2013-12-11T15:57:35Z [Term] id: FYPO:0002990 name: increased leucine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of leucine into the cell occurs to a greater extent than normal." [PomBase:mah] synonym: "increased leucine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased leucine import during vegetative growth" EXACT [PomBase:mah] synonym: "increased leucine import into cell" EXACT [PomBase:al] synonym: "increased leucine uptake" EXACT [PomBase:mah] is_a: FYPO:0001139 ! abnormal leucine import is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903801 ! L-leucine import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903801 ! L-leucine import into cell created_by: midori creation_date: 2013-12-11T16:01:01Z [Term] id: FYPO:0002991 name: advanced mitotic G1/S phase transition during cellular response to hydrogen peroxide def: "A cellular process phenotype in which progression through the G1/S transition of the mitotic cell cycle begins earlier than normal, during a cellular response to hydrogen peroxide." [PomBase:mah] synonym: "advanced mitotic G1/S phase transition during cellular response to H2O2" EXACT [PomBase:mah] synonym: "advanced mitotic G1/S phase transition during cellular response to hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] synonym: "premature cell cycle progression through mitotic G1/S phase transition during cellular response to hydrogen peroxide" EXACT [PomBase:mah] synonym: "premature mitotic G1/S phase transition during cellular response to hydrogen peroxide" EXACT [PomBase:mah] synonym: "premature mitotic G1/S phase transition during cellular response to hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000398 ! advanced mitotic G1/S phase transition intersection_of: PATO:0000694 ! premature intersection_of: happens_during GO:0070301 ! cellular response to hydrogen peroxide intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000082 ! G1/S transition of mitotic cell cycle relationship: happens_during GO:0070301 ! cellular response to hydrogen peroxide relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000082 ! G1/S transition of mitotic cell cycle created_by: midori creation_date: 2013-12-11T16:06:10Z [Term] id: FYPO:0002992 name: advanced mitotic G1/S phase transition during cellular response to methyl methanesulfonate def: "A cellular process phenotype in which progression through the G1/S transition of the mitotic cell cycle begins earlier than normal, during a cellular response to methyl methanesulfonate." [PomBase:mah] synonym: "advanced mitotic G1/S phase transition during cellular response to methyl methanesulfonate during vegetative growth" EXACT [PomBase:mah] synonym: "advanced mitotic G1/S phase transition during cellular response to methyl methanesulphonate" EXACT [PomBase:mah] synonym: "advanced mitotic G1/S phase transition during cellular response to MMS" EXACT [PomBase:mah] synonym: "premature cell cycle progression through mitotic G1/S phase transition during cellular response to methyl methanesulfonate" EXACT [PomBase:mah] synonym: "premature mitotic G1/S phase transition during cellular response to methyl methanesulfonate" EXACT [PomBase:mah] synonym: "premature mitotic G1/S phase transition during cellular response to methyl methanesulfonate during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000398 ! advanced mitotic G1/S phase transition intersection_of: PATO:0000694 ! premature intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: happens_during GO:0072703 ! cellular response to methyl methanesulfonate intersection_of: inheres_in GO:0000082 ! G1/S transition of mitotic cell cycle relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: happens_during GO:0072703 ! cellular response to methyl methanesulfonate relationship: inheres_in GO:0000082 ! G1/S transition of mitotic cell cycle created_by: midori creation_date: 2013-12-11T16:08:23Z [Term] id: FYPO:0002993 name: decreased protein phosphorylation during cellular response to methyl methanesulfonate def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal during a cellular response to methyl methanesulfonate." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein phosphorylation during cellular response to methyl methanesulfonate during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein phosphorylation during cellular response to methyl methanesulfonate during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein phosphorylation during cellular response to methyl methanesulphonate" EXACT [PomBase:mah] synonym: "decreased protein phosphorylation during cellular response to MMS" EXACT [PomBase:mah] synonym: "reduced protein phosphorylation during cellular response to methyl methanesulfonate" EXACT [PomBase:mah] synonym: "reduced protein phosphorylation during cellular response to MMS" EXACT [PomBase:mah] is_a: FYPO:0001838 ! decreased protein phosphorylation during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: happens_during GO:0072703 ! cellular response to methyl methanesulfonate intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: happens_during GO:0072703 ! cellular response to methyl methanesulfonate relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2013-12-11T16:40:16Z [Term] id: FYPO:0002994 name: increased protein localization to chromatin during mitotic S phase def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to chromatin is increased during S phase of the mitotic cell cycle." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to chromatin during mitotic S phase" EXACT [PomBase:mah] synonym: "increased protein localization to chromatin during mitotic S phase during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003011 ! increased protein localization to chromatin intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0000084 ! mitotic S phase intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071168 ! protein localization to chromatin relationship: happens_during GO:0000084 ! mitotic S phase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071168 ! protein localization to chromatin created_by: midori creation_date: 2013-12-11T16:53:07Z [Term] id: FYPO:0002995 name: normal regulation of DNA replication def: "A regulation phenotype observed in the vegetative growth phase of the life cycle in which regulation of DNA replication is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal regulation of DNA replication during mitotic cell cycle" EXACT [PomBase:mah] synonym: "normal regulation of DNA replication during vegetative growth" EXACT [PomBase:mah] synonym: "normal regulation of nuclear cell cycle DNA replication" EXACT [GO:0033262] is_a: FYPO:0001319 ! normal cellular process during vegetative growth is_a: FYPO:0001334 ! regulation phenotype during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0033262 ! regulation of nuclear cell cycle DNA replication intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0033262 ! regulation of nuclear cell cycle DNA replication relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-12-17T13:57:25Z [Term] id: FYPO:0002996 name: normal negative regulation of DNA replication during cellular response to hydrogen peroxide def: "A regulation phenotype in which regulation of DNA replication during the mitotic cell cycle is normal (i.e. indistinguishable from wild type) during a cellular response to hydrogen peroxide." [PomBase:mah] synonym: "normal negative regulation of DNA replication during cellular response to H2O2" EXACT [PomBase:mah] synonym: "normal negative regulation of nuclear cell cycle DNA replication during cellular response to hydrogen peroxide" EXACT [GO:1902576] is_a: FYPO:0001928 ! normal regulation of mitotic cell cycle intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0070301 ! cellular response to hydrogen peroxide intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0007346 ! regulation of mitotic cell cycle intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0070301 ! cellular response to hydrogen peroxide relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0007346 ! regulation of mitotic cell cycle relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-12-17T14:00:22Z [Term] id: FYPO:0002997 name: normal negative regulation of DNA replication during cellular response to methyl methanesulfonate def: "A regulation phenotype in which regulation of DNA replication during the mitotic cell cycle is normal (i.e. indistinguishable from wild type) during a cellular response to methyl methanesulfonate." [PomBase:mah] synonym: "normal negative regulation of DNA replication during cellular response to methyl methanesulphonate" EXACT [PomBase:mah] synonym: "normal negative regulation of DNA replication during cellular response to MMS" EXACT [PomBase:mah] synonym: "normal negative regulation of nuclear cell cycle DNA replication during cellular response to methyl methanesulfonate" EXACT [GO:1902576] is_a: FYPO:0002995 ! normal regulation of DNA replication intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: happens_during GO:0072703 ! cellular response to methyl methanesulfonate intersection_of: inheres_in GO:1902576 ! negative regulation of nuclear cell cycle DNA replication intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: happens_during GO:0072703 ! cellular response to methyl methanesulfonate relationship: inheres_in GO:1902576 ! negative regulation of nuclear cell cycle DNA replication relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-12-17T14:05:50Z [Term] id: FYPO:0002998 name: abolished actomyosin contractile ring assembly, clumped medial cortical nodes def: "A cytokinesis phenotype observed in the vegetative growth phase of the life cycle in which the assembly and distribution of actin filament bundles does not occur, resulting in the failure to form an actomyosin contractile ring, and in which medial cortical nodes form irregular clumps instead of coalescing into the medial cortex ring." [PMID:24127216, PomBase:mah] comment: Note that a ring structure may form without filamentous actin, but a ring lacking F-actin is not considered a contractile ring. synonym: "abolished actomyosin contractile ring assembly, clumped cytokinesis nodes" EXACT [PMID:24127216] synonym: "abolished actomyosin contractile ring assembly, clumped medial cortical nodes during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished actomyosin contractile ring assembly, clumped medial cortical nodes, during vegetative growth" EXACT [PomBase:mah] synonym: "abolished actomyosin contractile ring formation, clumped medial cortical nodes" RELATED [GO:0000915, PomBase:mah] synonym: "abolished contractile ring assembly, clumped medial cortical nodes" EXACT [PomBase:mah] synonym: "abolished cytokinetic contractile ring assembly, clumped medial cortical nodes" EXACT [PomBase:vw] synonym: "abolished cytokinetic ring assembly, clumped medial cortical nodes" RELATED [PomBase:vw] synonym: "abolished cytokinetic ring formation, clumped medial cortical nodes" RELATED [PomBase:vw] synonym: "abolished mitotic contractile ring assembly, clumped medial cortical nodes" EXACT [PomBase:vw] synonym: "actomyosin contractile ring assembly abolished, clumped medial cortical nodes" EXACT [PomBase:mah] synonym: "cytokinesis defects, contractile ring actin, absent, with clumped medial cortical nodes" RELATED [PomBase:mah] is_a: FYPO:0001009 ! abolished actomyosin contractile ring assembly created_by: midori creation_date: 2013-12-17T14:12:17Z [Term] id: FYPO:0002999 name: normal protein localization to medial cortical node def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the medial cortical nodes is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to medial cortical node" EXACT [PomBase:mah] synonym: "normal protein localization to cortical medial dot" EXACT [PomBase:vw] synonym: "normal protein localization to cytokinetic nodes" EXACT [PMID:24127216] synonym: "normal protein localization to medial cortical node during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to medial cortical node during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein localization to medial cortical nodes" EXACT [PomBase:mah] is_a: FYPO:0002558 ! normal protein localization to medial cortex during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902577 ! protein localization to medial cortical node intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902577 ! protein localization to medial cortical node relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2013-12-17T14:17:58Z [Term] id: FYPO:0003000 name: abolished actin filament polymerization def: "A cytokinesis phenotype observed in the vegetative growth phase of the life cycle in which the assembly of actin filaments from actin monomers does not occur." [PomBase:mah] synonym: "abolished actin filament polymerisation" EXACT [PomBase:mah] synonym: "abolished actin filament polymerization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished actin filament polymerization during vegetative growth" EXACT [PomBase:mah] synonym: "actin filament polymerization abolished" EXACT [PomBase:mah] is_a: FYPO:0001010 ! abolished actin filament organization intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0030041 ! actin filament polymerization relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0030041 ! actin filament polymerization created_by: midori creation_date: 2013-12-17T14:56:05Z [Term] id: FYPO:0003001 name: actin filaments present in greater numbers def: "A physical cellular phenotype in which cells contain more actin filaments than normal." [PomBase:mah] synonym: "extra actin filaments" EXACT [PomBase:mah] synonym: "increased level of actin filaments" EXACT [PomBase:al] synonym: "increased number of actin filaments" EXACT [PomBase:al] is_a: FYPO:0002398 ! abnormal actin cytoskeleton during vegetative growth is_a: PATO:0002002 ! has extra parts of type intersection_of: PATO:0002002 ! has extra parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0005884 ! actin filament relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0005884 ! actin filament created_by: midori creation_date: 2013-12-17T15:09:37Z [Term] id: FYPO:0003002 name: decreased protein localization to centromere during mitotic metaphase def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the centromere of a chromosome is decreased during metaphase of the mitotic cell cycle." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to centromere during mitotic metaphase" EXACT [PomBase:mah] synonym: "decreased protein localisation to chromosome, centromeric region during mitotic metaphase" EXACT [GO:0071459, PomBase:mah] synonym: "decreased protein localization to centromere during metaphase during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein localization to chromosome, centric region during mitotic metaphase" EXACT [GO:0071459, PomBase:mah] synonym: "decreased protein localization to chromosome, centromeric region during mitotic metaphase" EXACT [GO:0071459, PomBase:mah] synonym: "reduced protein localization to centromere during mitotic metaphase" EXACT [PomBase:mah] is_a: FYPO:0000450 ! decreased protein localization to centromere intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0000089 ! mitotic metaphase intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071459 ! protein localization to chromosome, centromeric region relationship: happens_during GO:0000089 ! mitotic metaphase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071459 ! protein localization to chromosome, centromeric region created_by: midori creation_date: 2013-12-17T15:26:00Z [Term] id: FYPO:0003003 name: increased protein localization to kinetochore during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the kinetochore of a chromosome is increased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to kinetochore during vegetative growth" EXACT [PomBase:mah] synonym: "increased protein localization to kinetochore during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000451 ! increased protein localization to centromere is_a: FYPO:0001268 ! abnormal protein localization to kinetochore during vegetative growth intersection_of: PATO:0002051 ! increased occurrence intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034501 ! protein localization to kinetochore relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034501 ! protein localization to kinetochore created_by: midori creation_date: 2013-12-17T15:27:08Z [Term] id: FYPO:0003004 name: increased cellular reactive oxygen species level during vegetative growth def: "A cell phenotype in which the amount of reactive oxygen species (ROS) measured in a cell is higher than normal in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "increased cellular reactive oxygen species accumulation during vegetative growth" RELATED [PomBase:mah] synonym: "increased cellular reactive oxygen species level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular ROS accumulation during vegetative growth" RELATED [PomBase:mah] synonym: "increased cellular ROS level during vegetative growth" EXACT [PomBase:mah] synonym: "increased ROS accumulation during vegetative growth" RELATED [PomBase:al] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth is_a: FYPO:0002142 ! altered cellular reactive oxygen species level intersection_of: PATO:0001162 ! increased concentration intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:26523 ! reactive oxygen species relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:26523 ! reactive oxygen species created_by: midori creation_date: 2013-12-17T15:47:02Z [Term] id: FYPO:0003005 name: inviable after spore germination, without cell division, with swollen, branched, elongated germ tube def: "A phenotype in which a spore germinates to produce an elongated germ tube that has a larger diameter and volume than normal and forms branches, and does not go on to form a viable dividing cell." [PomBase:mah] synonym: "essential; germinating spore with swollen, branched, elongated germ tube" RELATED [PomBase:mah] synonym: "inviable after spore germination with elongated swollen branched germ tube" EXACT [PomBase:mah] synonym: "inviable after spore germination, without cell division, swollen, branched, elongated cell" EXACT [PomBase:mah] synonym: "inviable following spore germination with swollen, branched, elongated germ tube" EXACT [PomBase:mah] synonym: "inviable germinated spore with swollen, branched, elongated germ tube" EXACT [PomBase:mah] is_a: FYPO:0002515 ! inviable after spore germination, without cell division, with branched, elongated germ tube is_a: FYPO:0002845 ! inviable swollen elongated septated cell is_a: FYPO:0002911 ! inviable after spore germination, without cell division, with swollen elongated germ tube is_a: FYPO:0004494 ! inviable branched, swollen, elongated vegetative cell created_by: midori creation_date: 2013-12-17T15:51:27Z [Term] id: FYPO:0003006 name: decreased protein phosphorylation during cellular response to caffeine def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal during a cellular response to caffeine." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein phosphorylation during cellular response to caffeine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein phosphorylation during cellular response to caffeine during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein phosphorylation during cellular response to caffeine" EXACT [PomBase:mah] is_a: FYPO:0001838 ! decreased protein phosphorylation during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0071313 ! cellular response to caffeine intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0071313 ! cellular response to caffeine relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2013-12-18T14:51:58Z [Term] id: FYPO:0003007 name: decreased protein level during cellular response to caffeine def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during a cellular response to caffeine is lower than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein accumulation during cellular response to caffeine" RELATED [PomBase:mah] synonym: "decreased protein level during cellular response to caffeine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein level during cellular response to caffeine during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein level during cellular response to caffeine" EXACT [PomBase:mah] is_a: FYPO:0001324 ! decreased protein level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0071313 ! cellular response to caffeine intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0071313 ! cellular response to caffeine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2013-12-18T14:52:59Z [Term] id: FYPO:0003008 name: decreased repression of transcription during cellular response to zinc def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which negative regulation of transcription from RNA polymerase II promoter occurs to a lower extent than normal during a cellular response to zinc. Specific genes are more highly transcribed in the presence of zinc in the mutant than in wild type." [PMID:22496451, PomBase:mah] synonym: "decreased negative regulation of transcription from RNA polymerase II promoter during cellular response to zinc" EXACT [GO:0000122, PomBase:mah] synonym: "decreased repression of transcription during cellular response to zinc during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased repression of transcription during cellular response to zinc during vegetative growth" EXACT [PomBase:mah] synonym: "decreased transcriptional repression during cellular response to zinc" EXACT [PomBase:mah] synonym: "reduced repression of transcription during cellular response to zinc" EXACT [PomBase:mah] is_a: FYPO:0000624 ! abnormal negative regulation of transcription during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0071294 ! cellular response to zinc ion intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0071294 ! cellular response to zinc ion relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-01-03T14:22:41Z [Term] id: FYPO:0003009 name: increased protein localization to centromere outer repeat def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the centromere outer repeat regions of a chromosome is increased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to centromere outer repeat" EXACT [PomBase:mah] synonym: "increased protein localisation to centromeric outer repeat region" EXACT [GO:0071459, PomBase:mah] synonym: "increased protein localization to centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein localization to centromere outer repeat during vegetative growth" EXACT [PomBase:mah] synonym: "increased protein localization to chromosome, centric outer repeat region" EXACT [GO:0071459, PomBase:mah] synonym: "increased protein localization to chromosome, centromeric outer repeat region" EXACT [GO:0071459, PomBase:mah] synonym: "increased protein localization to pericentric region" RELATED [PomBase:mah] synonym: "increased protein localization to pericentromeric region" RELATED [PomBase:mah] is_a: FYPO:0000449 ! abnormal protein localization to centromere is_a: FYPO:0002840 ! increased protein localization to chromosome intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034502 ! protein localization to chromosome intersection_of: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034502 ! protein localization to chromosome relationship: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region created_by: midori creation_date: 2014-01-03T14:40:14Z [Term] id: FYPO:0003010 name: increased protein localization to telomeric heterochromatin during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to heterochromatin at telomeres is increased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to telomeric heterochromatin during vegetative growth" EXACT [PomBase:mah] synonym: "increased protein localization to heterochromatin at telomere during vegetative growth" EXACT [PomBase:mah] synonym: "increased protein localization to telomeric heterochromatin during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001131 ! abnormal protein localization to heterochromatin during vegetative growth is_a: FYPO:0003011 ! increased protein localization to chromatin is_a: FYPO:0004656 ! increased protein localization to telomere intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990152 ! protein localization to telomeric heterochromatin relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990152 ! protein localization to telomeric heterochromatin created_by: midori creation_date: 2014-01-03T15:32:29Z [Term] id: FYPO:0003011 name: increased protein localization to chromatin def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to chromatin is increased." [PMID:23936074, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to chromatin" EXACT [PomBase:mah] synonym: "increased protein localization to chromatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein localization to chromatin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000452 ! abnormal protein localization to chromatin during vegetative growth is_a: FYPO:0002840 ! increased protein localization to chromosome intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071168 ! protein localization to chromatin relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071168 ! protein localization to chromatin created_by: midori creation_date: 2014-01-03T15:50:38Z [Term] id: FYPO:0003012 name: mitosis with unreplicated DNA def: "A cellular process phenotype in which cells attempt to undergo mitosis before they have begun to replicate genomic DNA." [PMID:11988741, PomBase:mah] is_a: FYPO:0001046 ! premature mitosis created_by: midori creation_date: 2014-01-08T15:00:35Z [Term] id: FYPO:0003013 name: abnormal actomyosin contractile ring disassembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which contractile ring disassembly is abnormal. Contractile ring disassembly is the part of cytokinesis in which the actomyosin contractile ring is disaggregated into its constituent components." [PomBase:mah] synonym: "abnormal actomyosin contractile ring disassembly during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal contractile ring disassembly" EXACT [PomBase:mah] synonym: "abnormal cytokinesis, actomyosin contractile ring disassembly" EXACT [PomBase:mah] synonym: "abnormal cytokinetic contractile ring disassembly" EXACT [PomBase:vw] synonym: "abnormal cytokinetic ring disassembly" RELATED [PomBase:vw] synonym: "abnormal mitotic actomyosin contractile ring disassembly" EXACT [PomBase:mah] synonym: "abnormal mitotic contractile ring disassembly" EXACT [PomBase:vw] is_a: FYPO:0000032 ! abnormal cytokinesis is_a: FYPO:0004738 ! abnormal actomyosin contractile ring organization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1990274 ! mitotic actomyosin contractile ring disassembly intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1990274 ! mitotic actomyosin contractile ring disassembly relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-01-15T10:21:16Z [Term] id: FYPO:0003014 name: decreased rate of actomyosin contractile ring disassembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the rate, or speed, of actomyosin contractile ring disassembly is decreased. Contractile ring disassembly is the part of cytokinesis in which the actomyosin contractile ring is disaggregated into its constituent components." [PomBase:mah] synonym: "decreased rate of actomyosin contractile ring disassembly during vegetative growth" EXACT [PomBase:mah] synonym: "decreased rate of contractile ring disassembly" EXACT [PomBase:mah] synonym: "decreased rate of cytokinetic contractile ring disassembly" EXACT [PomBase:vw] synonym: "decreased rate of mitotic contractile ring disassembly" EXACT [PomBase:mah] synonym: "reduced rate of actomyosin contractile ring disassembly" EXACT [PomBase:mah] is_a: FYPO:0003013 ! abnormal actomyosin contractile ring disassembly is_a: PATO:0000911 ! decreased rate intersection_of: PATO:0000911 ! decreased rate intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990274 ! mitotic actomyosin contractile ring disassembly relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990274 ! mitotic actomyosin contractile ring disassembly created_by: midori creation_date: 2014-01-15T10:22:22Z [Term] id: FYPO:0003015 name: cell lysis during cellular response to salt stress def: "An inviable phenotype observed in the vegetative growth phase of the life cycle in which a cell lyses, i.e. the plasma membrane ruptures and cytoplasm is lost, during a cellular response to salt stress. Note that in fission yeast cell lysis, the integrity of the cell wall is also compromised." [PomBase:mah] synonym: "cell lysis during cellular response to salt stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "cell lysis during cellular response to salt stress during vegetative growth" EXACT [PomBase:mah] synonym: "cytolysis during cellular response to salt stress" EXACT [PomBase:mah] synonym: "inviable, lysed cell during cellular response to salt stress" EXACT [PomBase:mah] synonym: "lysed cell in response to salt stress" EXACT [PomBase:al] is_a: FYPO:0000647 ! vegetative cell lysis intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0071472 ! cellular response to salt stress intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0019835 ! cytolysis relationship: happens_during GO:0071472 ! cellular response to salt stress relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0019835 ! cytolysis created_by: midori creation_date: 2014-01-15T10:54:08Z [Term] id: FYPO:0003016 name: cell lysis during cellular response to non-ionic osmotic stress def: "An inviable phenotype observed in the vegetative growth phase of the life cycle in which a cell lyses, i.e. the plasma membrane ruptures and cytoplasm is lost, during a cellular response to non-ionic osmotic stress. Note that in fission yeast cell lysis, the integrity of the cell wall is also compromised." [PomBase:mah] synonym: "cell lysis during cellular response to non-ionic osmotic stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "cell lysis during cellular response to non-ionic osmotic stress during vegetative growth" EXACT [PomBase:mah] synonym: "cytolysis during cellular response to non-ionic osmotic stress" EXACT [PomBase:mah] synonym: "inviable, lysed cell during cellular response to non-ionic osmotic stress" EXACT [PomBase:mah] synonym: "lysed cell in response to non-ionic osmotic stress" EXACT [PomBase:al] is_a: FYPO:0000647 ! vegetative cell lysis intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0071471 ! cellular response to non-ionic osmotic stress intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0019835 ! cytolysis relationship: happens_during GO:0071471 ! cellular response to non-ionic osmotic stress relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0019835 ! cytolysis created_by: midori creation_date: 2014-01-15T10:55:13Z [Term] id: FYPO:0003017 name: inviable elongated vegetative cell during cellular response to salt stress def: "A cell morphology phenotype in which a vegetative cell is inviable and longer than normal during a cellular response to salt stress." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "elongated inviable cell during cellular response to salt stress during vegetative growth" EXACT [PomBase:mah] synonym: "elongated inviable vegetative cell during cellular response to salt stress" EXACT [PomBase:mah] synonym: "essential; elongated vegetative cell during cellular response to salt stress" RELATED [PomBase:mah] synonym: "inviable elongated vegetative cell during cellular response to salt stress during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001490 ! inviable elongated vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0071472 ! cellular response to salt stress intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0071472 ! cellular response to salt stress relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2014-01-15T10:59:07Z [Term] id: FYPO:0003018 name: inviable elongated vegetative cell during cellular response to non-ionic osmotic stress def: "A cell morphology phenotype in which a vegetative cell is inviable and longer than normal during a cellular response to non-ionic osmotic stress." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "elongated inviable cell during cellular response to non-ionic osmotic stress during vegetative growth" EXACT [PomBase:mah] synonym: "elongated inviable vegetative cell during cellular response to non-ionic osmotic stress" EXACT [PomBase:mah] synonym: "essential; elongated vegetative cell during cellular response to v stress" RELATED [PomBase:mah] synonym: "inviable elongated vegetative cell during cellular response to non-ionic osmotic stress during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001490 ! inviable elongated vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0071471 ! cellular response to non-ionic osmotic stress intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0071471 ! cellular response to non-ionic osmotic stress relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2014-01-15T11:00:24Z [Term] id: FYPO:0003019 name: abnormal protein autophosphorylation during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the autophosphorylation of one or more specific proteins, or of specific protein sites, is abnormal. Protein autophosphorylation is the phosphorylation by a protein of one or more of its own amino acid residues, or residues on an identical protein." [GO:0031952, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein autophosphorylation during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000775 ! abnormal protein phosphorylation during vegetative growth is_a: FYPO:0001334 ! regulation phenotype during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0031952 ! regulation of protein autophosphorylation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0031952 ! regulation of protein autophosphorylation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-01-15T11:04:27Z [Term] id: FYPO:0003020 name: abolished protein autophosphorylation during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the autophosphorylation of one or more specific proteins, or of specific protein sites, does not occur. Protein autophosphorylation is the phosphorylation by a protein of one or more of its own amino acid residues, or residues on an identical protein." [GO:0031952, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein autophosphorylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein autophosphorylation abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002033 ! abolished protein phosphorylation during vegetative growth is_a: FYPO:0003019 ! abnormal protein autophosphorylation during vegetative growth intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0031952 ! regulation of protein autophosphorylation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0031952 ! regulation of protein autophosphorylation created_by: midori creation_date: 2014-01-15T11:05:00Z [Term] id: FYPO:0003021 name: sensitive to EPC def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to ethyl N-phenylcarbamate (EPC). Cells stop growing (and may die) at a concentration of EPC that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to EPC" EXACT [PomBase:mah] synonym: "sensitive to EPC during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to EPC during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to ethyl N-phenylcarbamate" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth created_by: midori creation_date: 2014-01-15T11:46:04Z [Term] id: FYPO:0003022 name: resistance to nocodazole def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of nocodazole than normal." [PomBase:mah] synonym: "resistance to nocodazole during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to nocodazole during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to nocodazole" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:34892 ! nocodazole relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:34892 ! nocodazole created_by: midori creation_date: 2014-01-15T13:47:40Z [Term] id: FYPO:0003023 name: normal growth on EPC def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing ethyl N-phenylcarbamate (EPC)." [PomBase:mah] synonym: "normal cell population growth in presence of EPC" EXACT [PomBase:mah] synonym: "normal cell population growth on EPC" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cell population growth on ethyl N-phenylcarbamate" EXACT [PomBase:mah] synonym: "normal cellular response to EPC" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on EPC" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth created_by: midori creation_date: 2014-01-15T13:49:48Z [Term] id: FYPO:0003024 name: abnormal homologous chromosome pairing def: "A cellular process phenotype in which homologous chromosome pairing during meiosis (synapsis) is abnormal. Synapsis is the process in which the side by side pairing and physical juxtaposition of homologous chromosomes is established and maintained. Pairing may be assayed globally or at one or more specific loci." [GO:0007129, PomBase:mah] synonym: "abnormal homologous chromosome pairing at meiosis" EXACT [GO:0007129] synonym: "abnormal synapsis" EXACT [GO:0007129] is_a: FYPO:0000641 ! abnormal chromosome organization is_a: FYPO:0002739 ! abnormal meiotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0007129 ! synapsis intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0007129 ! synapsis relationship: part_of FYPO:0000051 ! abnormal meiosis relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-01-15T14:42:37Z [Term] id: FYPO:0003025 name: decreased homologous chromosome pairing def: "A cellular process phenotype in which homologous chromosome pairing during meiosis (synapsis) is decreased. Synapsis is the process in which the side by side pairing and physical juxtaposition of homologous chromosomes is established and maintained. Pairing may be assayed globally or at one or more specific loci." [GO:0007129, PomBase:mah] synonym: "decreased homologous chromosome pairing at meiosis" EXACT [GO:0007129] synonym: "decreased synapsis" EXACT [GO:0007129] synonym: "reduced homologous chromosome pairing" EXACT [PomBase:mah] is_a: FYPO:0000628 ! abnormal cellular process is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0007129 ! synapsis relationship: inheres_in GO:0007129 ! synapsis created_by: midori creation_date: 2014-01-15T14:45:55Z [Term] id: FYPO:0003026 name: delayed homologous chromosome pairing def: "A cellular process phenotype in which homologous chromosome pairing during meiosis (synapsis) begins later than normal. Synapsis is the process in which the side by side pairing and physical juxtaposition of homologous chromosomes is established and maintained. Pairing may be assayed globally or at one or more specific loci." [GO:0007129, PomBase:mah] synonym: "delayed homologous chromosome pairing at meiosis" EXACT [GO:0007129] synonym: "delayed synapsis" EXACT [GO:0007129] is_a: FYPO:0000628 ! abnormal cellular process is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: inheres_in GO:0007129 ! synapsis relationship: inheres_in GO:0007129 ! synapsis created_by: midori creation_date: 2014-01-15T14:47:13Z [Term] id: FYPO:0003027 name: normal poly(A)+ mRNA export from nucleus def: "A transport phenotype observed in the vegetative growth phase of the life cycle in which the export of polyadenylated mRNA from the nucleus is normal." [PomBase:mah] synonym: "normal poly(A)+ mRNA export from nucleus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal poly(A)+ mRNA export from nucleus during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000509 ! normal nuclear export intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0016973 ! poly(A)+ mRNA export from nucleus intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0016973 ! poly(A)+ mRNA export from nucleus relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-01-15T15:57:46Z [Term] id: FYPO:0003028 name: normal actin cortical patch localization during mitosis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which actin cortical patch localization is normal during mitosis." [PomBase:mah] synonym: "abnormal actin patch localization during mitosis" EXACT [PomBase:vw] synonym: "normal actin cortical patch localisation during mitosis" EXACT [PomBase:mah] synonym: "normal actin cortical patch localization during mitosis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal actin cortical patch localization during mitosis during vegetative growth" EXACT [PomBase:mah] synonym: "normal actin cortical patch localization during mitotic M phase" EXACT [PomBase:mah] synonym: "normal actin cortical patch localization during mitotic nuclear division" EXACT [GO:0007067] synonym: "normal actin cortical patch location during mitosis" RELATED [PomBase:mah] is_a: FYPO:0001294 ! normal actin cortical patch localization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0007067 ! mitotic nuclear division intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051666 ! actin cortical patch localization intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0007067 ! mitotic nuclear division relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051666 ! actin cortical patch localization relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-01-15T16:04:43Z [Term] id: FYPO:0003029 name: decreased mRNA splicing, via spliceosome def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of mRNA splicing via the spliceosome is decreased." [PMID:24298023, PomBase:mah] synonym: "decreased mRNA splicing, via spliceosome during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased mRNA splicing, via spliceosome during vegetative growth" EXACT [PomBase:mah] synonym: "decreased nuclear mRNA splicing, via spliceosome" EXACT [PomBase:mah] synonym: "decreased splicing" BROAD [PomBase:al] synonym: "reduced mRNA splicing, via spliceosome" EXACT [PomBase:mah] is_a: FYPO:0000189 ! abnormal mRNA splicing, via spliceosome is_a: FYPO:0003040 ! decreased RNA splicing intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000398 ! mRNA splicing, via spliceosome relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000398 ! mRNA splicing, via spliceosome created_by: midori creation_date: 2014-01-17T14:14:59Z [Term] id: FYPO:0003030 name: decreased splicing of mRNA introns with low A/U content and polypyrimidine tracts distal to branch site def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of mRNA splicing via the spliceosome is decreased, where introns have low A/U content and polypyrimidine tracts located approximately 17-19 nt distal to the branch site." [PMID:24298023, PomBase:mah] synonym: "decreased mRNA splicing, via spliceosome, introns with low A/U content and polypyrimidine tracts distal to branch site" EXACT [PomBase:mah] synonym: "decreased nuclear mRNA splicing, via spliceosome, introns with low A/U content and polypyrimidine tracts distal to branch site" EXACT [PomBase:mah] synonym: "decreased splicing of mRNA introns with low A/U content and polypyrimidine tracts distal to branch site" BROAD [PomBase:al] synonym: "decreased splicing of mRNA introns with low A/U content and polypyrimidine tracts distal to branch site during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased splicing of mRNA introns with low A/U content and polypyrimidine tracts distal to branch site during vegetative growth" EXACT [PomBase:mah] synonym: "reduced splicing of mRNA introns with low A/U content and polypyrimidine tracts distal to branch site" EXACT [PomBase:mah] is_a: FYPO:0003242 ! decreased splicing of mRNA introns with low A/U content created_by: midori creation_date: 2014-01-17T14:22:16Z [Term] id: FYPO:0003031 name: conjugation without nitrogen starvation def: "A cellular process phenotype in which conjugation takes place in cells that are not subject to nitrogen starvation." [PomBase:mah] synonym: "conjugation in the absence of nitrogen starvation" EXACT [PomBase:al] synonym: "conjugation without nitrogen depletion" EXACT [PomBase:vw] synonym: "conjugation without nitrogen deprivation" EXACT [PomBase:vw] is_a: FYPO:0000031 ! abnormal conjugation created_by: midori creation_date: 2014-01-17T14:28:06Z [Term] id: FYPO:0003032 name: decreased RNA level during glucose starvation def: "A cell phenotype in which the amount of RNA measured in a cell when the cell is subject to glucose starvation is lower than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. This term can be used for any circumstances in which cells are starved for glucose. Note that cells may enter G0 (quiescence) when subjected to prolonged glucose starvation; this term is not restricted to G0. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased RNA accumulation during glucose starvation" RELATED [PomBase:mah] synonym: "decreased RNA level during glucose depletion" EXACT [PomBase:vw] synonym: "decreased RNA level during glucose deprivation" EXACT [PomBase:vw] synonym: "decreased transcript level during glucose starvation" EXACT [PomBase:vw] synonym: "reduced RNA level during glucose starvation" EXACT [PomBase:mah] is_a: FYPO:0000826 ! decreased RNA level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0042149 ! cellular response to glucose starvation intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0042149 ! cellular response to glucose starvation relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-01-17T14:30:03Z [Term] id: FYPO:0003033 name: increased RNA level during glucose starvation def: "A cell phenotype in which the amount of RNA measured in a cell when the cell is subject to glucose starvation is higher than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. This term can be used for any circumstances in which cells are starved for glucose. Note that cells may enter G0 (quiescence) when subjected to prolonged glucose starvation; this term is not restricted to G0. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased RNA accumulation during glucose starvation" RELATED [PomBase:mah] synonym: "increased RNA level during glucose depletion" EXACT [PomBase:vw] synonym: "increased RNA level during glucose deprivation" EXACT [PomBase:vw] synonym: "increased transcript level during glucose starvation" EXACT [PomBase:vw] is_a: FYPO:0001890 ! increased RNA level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0042149 ! cellular response to glucose starvation intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0042149 ! cellular response to glucose starvation relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-01-17T14:31:39Z [Term] id: FYPO:0003034 name: decreased RNA level during cellular response to UV def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to ultraviolet light is lower than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased RNA accumulation during cellular response to ultraviolet light" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to ultraviolet light" EXACT [GO:0034644] synonym: "decreased RNA level during cellular response to UV during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to UV during vegetative growth" EXACT [PomBase:mah] synonym: "decreased transcript level during cellular response to UV" EXACT [PomBase:vw] synonym: "reduced RNA level during cellular response to UV" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0034644 ! cellular response to UV intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0034644 ! cellular response to UV relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-01-17T14:44:21Z [Term] id: FYPO:0003035 name: normal RNA level during cellular response to UV def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to ultraviolet light is normal (i.e. indistinguishable from wild type). Total RNA or a specific RNA may be affected." [PomBase:mah] comment: We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "normal mRNA level during cellular response to UV" NARROW [PomBase:mah] synonym: "normal protein level during cellular response to ultraviolet light" EXACT [GO:0034644] synonym: "normal RNA accumulation during cellular response to UV" RELATED [PomBase:mah] synonym: "normal RNA level during cellular response to UV during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal RNA level during cellular response to UV during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001317 ! normal RNA level during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0034644 ! cellular response to UV intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0034644 ! cellular response to UV relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-01-17T14:52:09Z [Term] id: FYPO:0003036 name: normal transcription during cellular response to UV def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription occurs to a normal (i.e. indistinguishable from wild type) extent during a cellular response to ultraviolet light. All genes, or a specific subset of genes, may be measured." [PomBase:mah] synonym: "normal transcription during cellular response to ultraviolet light" EXACT [PomBase:mah] synonym: "normal transcription during cellular response to UV during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal transcription during cellular response to UV during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001855 ! normal transcription during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0034644 ! cellular response to UV intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006351 ! transcription, DNA-templated intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0034644 ! cellular response to UV relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006351 ! transcription, DNA-templated relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-01-17T15:05:39Z [Term] id: FYPO:0003037 name: abnormal cell phenotype def: "A phenotype that shows detectable differences from normal at the level of an individual cell. In fission yeast, the characteristics of wild type cells of the sequenced strain (972 h-) or the isogenic h+ or h90 strains are regarded as normal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "abnormal fission yeast cell phenotype" EXACT [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype is_a: FYPO:0001985 ! abnormal phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in FYPO:0000002 ! cell phenotype intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in FYPO:0000002 ! cell phenotype relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-01-17T15:10:08Z [Term] id: FYPO:0003038 name: abnormal RNA stability def: "A cell phenotype in which RNA stability is abnormal. RNA molecules may be more or less likely to degrade over a given time period than in wild type. Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [PomBase:mah] synonym: "altered RNA stability" EXACT [PomBase:mah] is_a: FYPO:0003037 ! abnormal cell phenotype created_by: midori creation_date: 2014-01-17T15:15:19Z [Term] id: FYPO:0003039 name: decreased RNA stability during cellular response to UV def: "A cell phenotype in which RNA stability is decreased during a cellular response to ultraviolet light. RNA molecules are more likely to degrade over a given time period than in wild type. Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [PMID:10954610, PomBase:mah] synonym: "decreased RNA stability during cellular response to ultraviolet light" EXACT [PomBase:mah] synonym: "decreased RNA stability during cellular response to UV during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased RNA stability during cellular response to UV during vegetative growth" EXACT [PomBase:mah] synonym: "reduced RNA stability during cellular response to UV" EXACT [PomBase:mah] is_a: FYPO:0001320 ! vegetative cell phenotype is_a: FYPO:0003038 ! abnormal RNA stability created_by: midori creation_date: 2014-01-17T15:17:32Z [Term] id: FYPO:0003040 name: decreased RNA splicing def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of RNA splicing is decreased. All RNA splicing may be increased, or splicing of one or more specific RNA molecules may be selectively affected." [PomBase:mah] synonym: "decreased RNA splicing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased RNA splicing during vegetative growth" EXACT [PomBase:mah] synonym: "decreased RNA splicing, via transesterification reactions with bulged adenosine as nucleophile" EXACT [GO:0000377] synonym: "reduced RNA splicing" EXACT [PomBase:mah] is_a: FYPO:0002915 ! abnormal RNA splicing is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile created_by: midori creation_date: 2014-01-17T15:37:15Z [Term] id: FYPO:0003041 name: decreased snRNA splicing def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of splicing of small nuclear RNA (snRNA) primary transcripts is decreased." [PomBase:mah] synonym: "decreased snRNA primary transcript RNA splicing" EXACT [PomBase:mah] synonym: "decreased snRNA splicing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased snRNA splicing during vegetative growth" EXACT [PomBase:mah] synonym: "increased snRNA splicing, via transesterification reactions with bulged adenosine as nucleophile" EXACT [GO:0000377] synonym: "reduced snRNA splicing" EXACT [PomBase:mah] is_a: FYPO:0003040 ! decreased RNA splicing intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile intersection_of: towards SO:0000231 ! snRNA_primary_transcript relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile relationship: towards SO:0000231 ! snRNA_primary_transcript created_by: midori creation_date: 2014-01-17T15:37:22Z [Term] id: FYPO:0003042 name: abolished protein localization to Mmi1 focus def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the Mmi1 nuclear focus complex is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to Mmi1 focus" EXACT [PomBase:mah] synonym: "abolished protein localization to Mmi1 focus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to Mmi1 focus during vegetative growth" EXACT [PomBase:mah] synonym: "abolished protein localization to Mmi1 nuclear focus complex" EXACT [GO:1990251] synonym: "protein localization to Mmi1 focus abolished" EXACT [PomBase:mah] is_a: FYPO:0001424 ! abolished protein localization to nucleus during vegetative growth is_a: FYPO:0002963 ! abnormal protein localization to Mmi1 focus intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1902666 ! protein localization to Mmi1 nuclear focus complex relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1902666 ! protein localization to Mmi1 nuclear focus complex created_by: midori creation_date: 2014-01-29T15:46:29Z [Term] id: FYPO:0003043 name: increased protein localization to Mei2 nuclear dot def: "A cell phenotype in which the localization of a protein to the Mei2 nuclear dot is increased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to Mei2 nuclear dot" EXACT [PomBase:mah] is_a: FYPO:0002958 ! abnormal protein localization to Mei2 nuclear dot is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: towards GO:1902549 ! protein localization to Mei2 nuclear dot relationship: towards GO:1902549 ! protein localization to Mei2 nuclear dot created_by: midori creation_date: 2014-01-29T16:11:04Z [Term] id: FYPO:0003044 name: abnormal heterochromatin assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which heterochromatin assembly is abnormal. Heterochromatin assembly is the assembly of chromatin into a compact and highly condensed form that is often, but not always, transcriptionally silent." [GO:0031507, PomBase:mah] synonym: "abnormal heterochromatin assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal heterochromatin assembly during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal heterochromatin formation" EXACT [GO:0031507, PomBase:mah] is_a: FYPO:0001354 ! abnormal cellular component assembly during vegetative growth is_a: FYPO:0004543 ! abnormal heterochromatin organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0031507 ! heterochromatin assembly intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0031507 ! heterochromatin assembly relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-01-29T16:26:24Z [Term] id: FYPO:0003045 name: heterochromatin assembly beyond boundary element IRC1R def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which heterochromatin is assembled over a larger region near the centromere than normal, such that it extends beyond the IRC1R boundary element." [PMID:24013502, PomBase:mah] synonym: "heterochromatin formation beyond boundary element IRC1R" EXACT [PomBase:mah] is_a: FYPO:0003044 ! abnormal heterochromatin assembly created_by: midori creation_date: 2014-01-29T16:28:55Z [Term] id: FYPO:0003046 name: heterochromatin assembly beyond boundary element IRC3L def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which heterochromatin is assembled over a larger region near the centromere than normal, such that it extends beyond the IRC3L boundary element." [PMID:24013502, PomBase:mah] synonym: "heterochromatin formation beyond boundary element IRC3L" EXACT [PomBase:mah] is_a: FYPO:0003044 ! abnormal heterochromatin assembly created_by: midori creation_date: 2014-01-29T16:36:04Z [Term] id: FYPO:0003047 name: heterochromatin assembly beyond boundary element IRR def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which heterochromatin is assembled over a larger region near the silent mating-type cassette than normal, such that it extends beyond the IRR boundary element." [PMID:24013502, PomBase:mah] synonym: "heterochromatin formation beyond boundary element IRR" EXACT [PomBase:mah] is_a: FYPO:0003044 ! abnormal heterochromatin assembly created_by: midori creation_date: 2014-01-29T16:35:30Z [Term] id: FYPO:0003048 name: abnormal transcript length def: "A phenotype in which a transcript, i.e. an RNA molecule synthesized on a DNA template by RNA polymerase, has an abnormal length." [PMID:22582262, PomBase:mah, SO:0000673] is_a: FYPO:0001985 ! abnormal phenotype is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length intersection_of: inheres_in SO:0000673 ! transcript intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in SO:0000673 ! transcript relationship: output_of FYPO:0000290 ! transcription phenotype during vegetative growth relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-01-29T17:37:56Z [Term] id: FYPO:0003049 name: increased transcript length by 3' extension def: "A phenotype in which a transcript, i.e. an RNA molecule synthesized on a DNA template by RNA polymerase, is longer than normal due to inclusion of more RNA at the 3' end." [PMID:22582262, PomBase:mah, SO:0000673] synonym: "3'-extended transcript" EXACT [PomBase:mah] synonym: "poly(A) readthrough" RELATED [PomBase:vw] is_a: FYPO:0003048 ! abnormal transcript length created_by: midori creation_date: 2014-01-29T17:38:21Z [Term] id: FYPO:0003050 name: normal homologous chromosome pairing def: "A cellular process phenotype in which homologous chromosome pairing during meiosis (synapsis) is normal (i.e. indistinguishable from wild type). Synapsis is the process in which the side by side pairing and physical juxtaposition of homologous chromosomes is established and maintained. Pairing may be assayed globally or at one or more specific loci." [GO:0007129, PomBase:mah] synonym: "normal homologous chromosome pairing at meiosis" EXACT [GO:0007129] synonym: "normal synapsis" EXACT [GO:0007129] is_a: FYPO:0000627 ! normal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0007129 ! synapsis intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0007129 ! synapsis relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-01-30T14:00:10Z [Term] id: FYPO:0003051 name: normal homologous chromosome pairing at cis-acting homologous chromosome pairing region def: "A cellular process phenotype in which homologous chromosome pairing during meiosis (synapsis) is normal (i.e. indistinguishable from wild type) at a cis-acting homologous chromosome pairing region such as the sme2 locus." [PMID:22582262, PMID:23117617, PMID:24173580, PomBase:mah] synonym: "normal homologous chromosome pairing at meiosis at cis-acting homologous chromosome pairing region" EXACT [GO:0007129] synonym: "normal homologous chromosome pairing at sme2 locus" NARROW [PomBase:mah] synonym: "normal synapsis at cis-acting homologous chromosome pairing region" EXACT [GO:0007129] is_a: FYPO:0003050 ! normal homologous chromosome pairing intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0007129 ! synapsis intersection_of: occurs_at SO:0002025 ! cis_acting_homologous_chromosome_pairing_region intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0007129 ! synapsis relationship: occurs_at SO:0002025 ! cis_acting_homologous_chromosome_pairing_region relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-01-30T14:03:25Z [Term] id: FYPO:0003052 name: abnormal homologous chromosome pairing at cis-acting homologous chromosome pairing region def: "A cellular process phenotype in which homologous chromosome pairing during meiosis (synapsis) is abnormal at a cis-acting homologous chromosome pairing region such as the sme2 locus." [PMID:22582262, PMID:23117617, PMID:24173580, PomBase:mah] synonym: "abnormal homologous chromosome pairing at meiosis at cis-acting homologous chromosome pairing region" EXACT [GO:0007129] synonym: "abnormal homologous chromosome pairing at sme2 locus" NARROW [PomBase:mah] synonym: "abnormal synapsis at cis-acting homologous chromosome pairing region" EXACT [GO:0007129] is_a: FYPO:0003024 ! abnormal homologous chromosome pairing intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0007129 ! synapsis intersection_of: occurs_at SO:0002025 ! cis_acting_homologous_chromosome_pairing_region intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0007129 ! synapsis relationship: occurs_at SO:0002025 ! cis_acting_homologous_chromosome_pairing_region relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-01-30T14:33:16Z [Term] id: FYPO:0003053 name: increased homologous chromosome pairing at cis-acting homologous chromosome pairing region def: "A cellular process phenotype in which homologous chromosome pairing during meiosis (synapsis) is increased (i.e. occurs to a greater extent) at a cis-acting homologous chromosome pairing region such as the sme2 locus." [PMID:22582262, PMID:23117617, PMID:24173580, PomBase:mah] synonym: "increased homologous chromosome pairing at meiosis at cis-acting homologous chromosome pairing region" EXACT [GO:0007129] synonym: "increased homologous chromosome pairing at sme2 locus" NARROW [PomBase:mah] synonym: "increased synapsis at cis-acting homologous chromosome pairing region" EXACT [GO:0007129] is_a: FYPO:0003052 ! abnormal homologous chromosome pairing at cis-acting homologous chromosome pairing region is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0007129 ! synapsis intersection_of: occurs_at SO:0002025 ! cis_acting_homologous_chromosome_pairing_region relationship: inheres_in GO:0007129 ! synapsis relationship: occurs_at SO:0002025 ! cis_acting_homologous_chromosome_pairing_region created_by: midori creation_date: 2014-01-30T14:37:27Z [Term] id: FYPO:0003054 name: decreased homologous chromosome pairing at cis-acting homologous chromosome pairing region def: "A cellular process phenotype in which homologous chromosome pairing during meiosis (synapsis) is decreased (i.e. occurs to a lower extent) at a cis-acting homologous chromosome pairing region such as the sme2 locus." [PMID:22582262, PMID:23117617, PMID:24173580, PomBase:mah] synonym: "decreased homologous chromosome pairing at meiosis at cis-acting homologous chromosome pairing region" EXACT [GO:0007129] synonym: "decreased homologous chromosome pairing at sme2 locus" NARROW [PomBase:mah] synonym: "decreased synapsis at cis-acting homologous chromosome pairing region" EXACT [GO:0007129] synonym: "reduced homologous chromosome pairing at cis-acting homologous chromosome pairing region" EXACT [PomBase:mah] is_a: FYPO:0003025 ! decreased homologous chromosome pairing is_a: FYPO:0003052 ! abnormal homologous chromosome pairing at cis-acting homologous chromosome pairing region intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0007129 ! synapsis intersection_of: occurs_at SO:0002025 ! cis_acting_homologous_chromosome_pairing_region relationship: inheres_in GO:0007129 ! synapsis relationship: occurs_at SO:0002025 ! cis_acting_homologous_chromosome_pairing_region created_by: midori creation_date: 2014-01-30T14:45:24Z [Term] id: FYPO:0003055 name: delayed homologous chromosome pairing at cis-acting homologous chromosome pairing region def: "A cellular process phenotype in which homologous chromosome pairing during meiosis (synapsis) is delayed at a cis-acting homologous chromosome pairing region such as the sme2 locus." [PMID:22582262, PMID:23117617, PMID:24173580, PomBase:mah] synonym: "delayed homologous chromosome pairing at meiosis at cis-acting homologous chromosome pairing region" EXACT [GO:0007129] synonym: "delayed homologous chromosome pairing at sme2 locus" NARROW [PomBase:mah] synonym: "delayed synapsis at cis-acting homologous chromosome pairing region" EXACT [GO:0007129] is_a: FYPO:0003026 ! delayed homologous chromosome pairing is_a: FYPO:0003052 ! abnormal homologous chromosome pairing at cis-acting homologous chromosome pairing region intersection_of: PATO:0000502 ! delayed intersection_of: inheres_in GO:0007129 ! synapsis intersection_of: occurs_at SO:0002025 ! cis_acting_homologous_chromosome_pairing_region relationship: inheres_in GO:0007129 ! synapsis relationship: occurs_at SO:0002025 ! cis_acting_homologous_chromosome_pairing_region created_by: midori creation_date: 2014-01-30T14:46:10Z [Term] id: FYPO:0003056 name: Mei2 nuclear dot absent from cell def: "A cell phenotype in which the cell does not contain a detectable Mei2 nuclear dot complex." [PomBase:mah] synonym: "absence of Mei2 dot" EXACT [PomBase:vw] synonym: "absent Mei2 nuclear dot" EXACT [PomBase:mah] synonym: "Mei2 nuclear dot complex absent from cell" EXACT [GO:0033620] is_a: FYPO:0003684 ! altered level of macromolecular complex is_a: PATO:0002000 ! lacks all parts of type intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards GO:0033620 ! Mei2 nuclear dot complex relationship: inheres_in CL:0000000 ! cell relationship: towards GO:0033620 ! Mei2 nuclear dot complex created_by: midori creation_date: 2014-01-30T14:58:38Z [Term] id: FYPO:0003057 name: abnormal RNA localization def: "A cell phenotype in which the localization of an RNA in a cell is abnormal. An RNA may be observed in a place where it is not normally found, absent from a place where it is normally found, or both." [PomBase:mah] synonym: "abnormal cellular RNA localisation" EXACT [PomBase:mah] synonym: "abnormal cellular RNA localization" EXACT [PomBase:mah] synonym: "abnormal RNA localisation" EXACT [PomBase:mah] is_a: FYPO:0000138 ! localization phenotype is_a: FYPO:0000628 ! abnormal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0006403 ! RNA localization intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0006403 ! RNA localization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-01-30T16:00:06Z [Term] id: FYPO:0003058 name: normal RNA localization def: "A cell phenotype in which the localization of an RNA in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular RNA localisation" EXACT [PomBase:mah] synonym: "normal cellular RNA localization" EXACT [PomBase:mah] synonym: "normal RNA localisation" EXACT [PomBase:mah] is_a: FYPO:0000138 ! localization phenotype is_a: FYPO:0000627 ! normal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0006403 ! RNA localization intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0006403 ! RNA localization relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-01-30T16:05:30Z [Term] id: FYPO:0003059 name: normal RNA localization to chromatin def: "A cell phenotype in which the localization of an RNA to chromatin is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal RNA localisation to chromatin" EXACT [PomBase:mah] is_a: FYPO:0003058 ! normal RNA localization intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:1990280 ! RNA localization to chromatin intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:1990280 ! RNA localization to chromatin relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-01-30T16:06:28Z [Term] id: FYPO:0003060 name: decreased meiotic recombination at cis-acting homologous chromosome pairing region def: "A cellular process phenotype in which the occurrence of reciprocal meiotic recombination at a cis-acting homologous chromosome pairing region such as the sme2 locus is decreased." [PomBase:mah] synonym: "decreased meiotic recombination at sme2 locus" NARROW [PomBase:mah] synonym: "reduced meiotic recombination at cis-acting homologous chromosome pairing region" EXACT [PomBase:mah] is_a: FYPO:0000485 ! decreased meiotic recombination intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0007131 ! reciprocal meiotic recombination intersection_of: occurs_at SO:0002025 ! cis_acting_homologous_chromosome_pairing_region relationship: inheres_in GO:0007131 ! reciprocal meiotic recombination relationship: occurs_at SO:0002025 ! cis_acting_homologous_chromosome_pairing_region created_by: midori creation_date: 2014-01-30T16:09:19Z [Term] id: FYPO:0003061 name: twin haploid meiosis def: "A cellular process phenotype in which the two nuclei in a cell formed by conjugation undergo meiosis before karyogamy is completed. Note that this can occur in h-/h- or h+/h+ diploids, or in zygotes." [PMID:23755176, PomBase:al, PomBase:mah] synonym: "haploid meiosis before karyogamy" EXACT [PomBase:al] is_a: FYPO:0000479 ! premature meiosis created_by: midori creation_date: 2014-01-30T16:35:28Z [Term] id: FYPO:0003062 name: abnormal nuclear migration during mating def: "A cellular process phenotype in which nuclear migration involved in conjugation with cellular fusion is abnormal." [PomBase:mah] synonym: "abnormal nuclear congression during karyogamy" RELATED [PomBase:al] synonym: "abnormal nuclear migration involved in conjugation with cellular fusion" EXACT [GO:0000743] is_a: FYPO:0000517 ! abnormal nucleus localization is_a: FYPO:0001720 ! abnormal transport intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0000743 ! nuclear migration involved in conjugation with cellular fusion intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0000743 ! nuclear migration involved in conjugation with cellular fusion relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-01-30T16:43:32Z [Term] id: FYPO:0003063 name: abnormal cytoskeleton morphology def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of the cytoskeleton is abnormal." [PomBase:mah] comment: Note that an abnormal cytoskeleton organization process may, but does not necessarily, result in abnormal cytoskeleton morphology. is_a: FYPO:0002397 ! abnormal cytoskeleton is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: inheres_in GO:0005856 ! cytoskeleton intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0005856 ! cytoskeleton relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-01-30T16:47:41Z [Term] id: FYPO:0003064 name: abnormal microtubule cytoskeleton morphology def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of the microtubule cytoskeleton is abnormal." [PomBase:mah] comment: Note that an abnormal microtubule cytoskeleton organization process may, but does not necessarily, result in abnormal microtubule cytoskeleton morphology. is_a: FYPO:0002399 ! abnormal microtubule cytoskeleton is_a: FYPO:0003063 ! abnormal cytoskeleton morphology intersection_of: PATO:0000051 ! morphology intersection_of: inheres_in GO:0015630 ! microtubule cytoskeleton intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0015630 ! microtubule cytoskeleton relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-01-30T16:47:52Z [Term] id: FYPO:0003065 name: abnormal microtubule cytoskeleton morphology during mating def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of the microtubule cytoskeleton is abnormal during conjugation with cellular fusion." [PomBase:mah] comment: Note that an abnormal microtubule cytoskeleton organization process may, but does not necessarily, result in abnormal microtubule cytoskeleton morphology. synonym: "abnormal microtubule cytoskeleton morphology during conjugation with cellular fusion" EXACT [GO:0000747] synonym: "abnormal microtubule cytoskeleton morphology during karyogamy" RELATED [PomBase:al] is_a: FYPO:0003064 ! abnormal microtubule cytoskeleton morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0000747 ! conjugation with cellular fusion intersection_of: inheres_in GO:0015630 ! microtubule cytoskeleton intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0000747 ! conjugation with cellular fusion relationship: inheres_in GO:0015630 ! microtubule cytoskeleton relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-01-30T16:52:27Z [Term] id: FYPO:0003066 name: abnormal sporulation resulting in formation of ascus with fewer than four spores def: "A sporulation phenotype in which asci that contain one, two, or three spores form following conjugation and subsequent sporulation." [PomBase:al, PomBase:mah] synonym: "abnormal ascospore formation resulting in formation of asci with fewer than four spores" EXACT [GO:0030437, PomBase:mah] synonym: "abnormal sporulation resulting in formation of asci with fewer than four spores" EXACT [PomBase:mah] is_a: FYPO:0001894 ! abnormal sporulation resulting in formation of ascus with more or fewer than four spores created_by: midori creation_date: 2014-01-30T17:00:30Z [Term] id: FYPO:0003067 name: abnormal replication fork reversal def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which stalled replication forks are unwound four-stranded structures resembling Holliday junctions, but are not subsequently resolved correctly." [PomBase:mah] synonym: "abnormal replication fork reversal during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal replication fork reversal during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003586 ! abnormal replication fork processing intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0071932 ! replication fork reversal intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0071932 ! replication fork reversal relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-02-04T15:09:57Z [Term] id: FYPO:0003068 name: decreased protein localization to chromatin at replication forks during cellular response to hydroxyurea def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to chromatin at replication forks is decreased during a cellular response to hydroxyurea." [PMID:22682245, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to chromatin at replication forks during cellular response to hydroxyurea" EXACT [PomBase:mah] synonym: "decreased protein localization to chromatin at replication forks during cellular response to HU" EXACT [PomBase:mah] synonym: "decreased protein localization to chromatin at replication forks during cellular response to hydroxyurea during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to chromatin at replication forks during cellular response to hydroxyurea during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to chromatin at replication forks during cellular response to hydroxyurea" EXACT [PomBase:mah] is_a: FYPO:0002909 ! decreased protein localization to chromatin during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: happens_during GO:0072711 ! cellular response to hydroxyurea intersection_of: inheres_in GO:0071168 ! protein localization to chromatin intersection_of: occurs_at GO:0043596 ! nuclear replication fork relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: happens_during GO:0072711 ! cellular response to hydroxyurea relationship: inheres_in GO:0071168 ! protein localization to chromatin relationship: occurs_at GO:0043596 ! nuclear replication fork created_by: midori creation_date: 2014-02-04T15:48:16Z [Term] id: FYPO:0003069 name: normal protein localization to chromatin at replication forks during cellular response to hydroxyurea def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to chromatin at replication forks is normal (i.e. indistinguishable from wild type) during a cellular response to hydroxyurea." [PMID:22682245, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to chromatin at replication forks during cellular response to hydroxyurea" EXACT [PomBase:mah] synonym: "normal protein localization to chromatin at nuclear replication forks during cellular response to hydroxyurea" EXACT [GO:0043596] synonym: "normal protein localization to chromatin at replication forks during cellular response to HU" EXACT [PomBase:mah] synonym: "normal protein localization to chromatin at replication forks during cellular response to hydroxyurea during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to chromatin at replication forks during cellular response to hydroxyurea during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001509 ! normal protein localization to chromatin intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: happens_during GO:0072711 ! cellular response to hydroxyurea intersection_of: inheres_in GO:0071168 ! protein localization to chromatin intersection_of: occurs_at GO:0043596 ! nuclear replication fork intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: happens_during GO:0072711 ! cellular response to hydroxyurea relationship: inheres_in GO:0071168 ! protein localization to chromatin relationship: occurs_at GO:0043596 ! nuclear replication fork relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-02-04T16:02:45Z [Term] id: FYPO:0003070 name: abnormal single-stranded DNA 5'-3' exodeoxyribonuclease activity def: "A molecular function phenotype in which the observed rate of a single-stranded DNA 5'-3' exodeoxyribonuclease activity is abnormal." [PomBase:mah] is_a: FYPO:0003163 ! abnormal nuclease activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0045145 ! single-stranded DNA 5'-3' exodeoxyribonuclease activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0045145 ! single-stranded DNA 5'-3' exodeoxyribonuclease activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-02-04T16:06:17Z [Term] id: FYPO:0003071 name: abolished single-stranded DNA 5'-3' exodeoxyribonuclease activity def: "A molecular function phenotype in which a single-stranded DNA 5'-3' exodeoxyribonuclease activity is absent." [PomBase:mah] synonym: "single-stranded DNA 5'-3' exodeoxyribonuclease activity abolished" EXACT [PomBase:mah] is_a: FYPO:0003070 ! abnormal single-stranded DNA 5'-3' exodeoxyribonuclease activity is_a: FYPO:0003164 ! abolished nuclease activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0045145 ! single-stranded DNA 5'-3' exodeoxyribonuclease activity relationship: towards GO:0045145 ! single-stranded DNA 5'-3' exodeoxyribonuclease activity created_by: midori creation_date: 2014-02-04T16:06:25Z [Term] id: FYPO:0003072 name: abnormal primary amine oxidase activity def: "A molecular function phenotype in which the observed rate of primary amine oxidase activity is abnormal." [PomBase:mah] synonym: "decreased copper amine oxidase activity" NARROW [PomBase:mah] is_a: FYPO:0000689 ! abnormal oxidoreductase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0008131 ! primary amine oxidase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0008131 ! primary amine oxidase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-02-06T11:28:56Z [Term] id: FYPO:0003073 name: decreased primary amine oxidase activity def: "A molecular function phenotype in which the observed rate of primary amine oxidase activity is decreased." [PomBase:mah] synonym: "decreased copper amine oxidase activity" NARROW [PomBase:mah] synonym: "reduced primary amine oxidase activity" EXACT [PomBase:mah] is_a: FYPO:0000690 ! decreased oxidoreductase activity is_a: FYPO:0003072 ! abnormal primary amine oxidase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0008131 ! primary amine oxidase activity relationship: inheres_in GO:0008131 ! primary amine oxidase activity created_by: midori creation_date: 2014-02-06T11:29:12Z [Term] id: FYPO:0003074 name: abolished protein localization to nuclear centromeric heterochromatin def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to nuclear centromeric heterochromatin is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to nuclear centromeric heterochromatin during vegetative growth" EXACT [PomBase:mah] synonym: "abolished protein localization to nuclear centric heterochromatin" EXACT [GO:1902682] synonym: "abolished protein localization to nuclear centromeric heterochromatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein localization to nuclear centromeric heterochromatin during vegetative growth abolished" EXACT [PomBase:mah] is_a: FYPO:0000634 ! abolished protein localization to centromere is_a: FYPO:0001132 ! abolished protein localization to heterochromatin during vegetative growth is_a: FYPO:0001424 ! abolished protein localization to nucleus during vegetative growth intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1902682 ! protein localization to nuclear pericentric heterochromatin relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1902682 ! protein localization to nuclear pericentric heterochromatin created_by: midori creation_date: 2014-02-06T11:51:20Z [Term] id: FYPO:0003075 name: normal protein kinase activity def: "A molecular function phenotype in which the observed rate of a protein kinase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004672 ! protein kinase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0004672 ! protein kinase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-02-06T11:56:28Z [Term] id: FYPO:0003076 name: normal protein autophosphorylation during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the autophosphorylation of one or more specific proteins, or of specific protein sites, is normal (i.e. indistinguishable from wild type). Protein autophosphorylation is the phosphorylation by a protein of one or more of its own amino acid residues, or residues on an identical protein." [GO:0031952, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein autophosphorylation during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000776 ! normal protein phosphorylation during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0046777 ! protein autophosphorylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0046777 ! protein autophosphorylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-02-06T12:00:05Z [Term] id: FYPO:0003077 name: increased protein autophosphorylation during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of autophosphorylation of one or more specific proteins, or of specific protein sites, is increased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein autophosphorylation during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001038 ! increased protein phosphorylation during vegetative growth is_a: FYPO:0003019 ! abnormal protein autophosphorylation during vegetative growth intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0046777 ! protein autophosphorylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0046777 ! protein autophosphorylation created_by: midori creation_date: 2014-02-06T14:05:27Z [Term] id: FYPO:0003078 name: abolished protein autophosphorylation during cellular response to DNA damage def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the autophosphorylation of one or more specific proteins, or of specific protein sites, does not occur during a cellular response to DNA damage. Protein autophosphorylation is the phosphorylation by a protein of one or more of its own amino acid residues, or residues on an identical protein." [GO:0031952, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein autophosphorylation during cellular response to DNA damage during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein autophosphorylation during cellular response to DNA damage during vegetative growth" EXACT [PomBase:mah] synonym: "protein autophosphorylation abolished during cellular response to DNA damage during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002898 ! abolished protein phosphorylation during cellular response to DNA damage is_a: FYPO:0003019 ! abnormal protein autophosphorylation during vegetative growth intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0006974 ! cellular response to DNA damage stimulus intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0046777 ! protein autophosphorylation relationship: during GO:0006974 ! cellular response to DNA damage stimulus relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0046777 ! protein autophosphorylation created_by: midori creation_date: 2014-02-06T14:07:01Z [Term] id: FYPO:0003079 name: abnormal genetic imprinting at mating-type locus def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which genetic imprinting at the mating-type locus is abnormal." [PomBase:mah] synonym: "abnormal genetic imprinting at mating-type locus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal genetic imprinting at mating-type locus during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001334 ! regulation phenotype during vegetative growth is_a: FYPO:0001346 ! DNA metabolism phenotype during vegetative growth is_a: FYPO:0001363 ! abnormal metabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0071515 ! genetic imprinting at mating-type locus intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0071515 ! genetic imprinting at mating-type locus relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-02-06T14:35:53Z [Term] id: FYPO:0003080 name: abolished genetic imprinting at mating-type locus def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which genetic imprinting at the mating-type locus does not occur." [PomBase:mah] synonym: "abolished genetic imprinting at mating-type locus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "genetic imprinting at mating-type locus abolished" EXACT [PomBase:mah] synonym: "genetic imprinting at mating-type locus abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003079 ! abnormal genetic imprinting at mating-type locus is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0071515 ! genetic imprinting at mating-type locus relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0071515 ! genetic imprinting at mating-type locus created_by: midori creation_date: 2014-02-06T14:36:37Z [Term] id: FYPO:0003081 name: decreased genetic imprinting at mating-type locus def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which genetic imprinting at the mating-type locus occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased genetic imprinting at mating-type locus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased genetic imprinting at mating-type locus during vegetative growth" EXACT [PomBase:mah] synonym: "reduced genetic imprinting at mating-type locus" EXACT [PomBase:mah] is_a: FYPO:0003079 ! abnormal genetic imprinting at mating-type locus is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071515 ! genetic imprinting at mating-type locus relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071515 ! genetic imprinting at mating-type locus created_by: midori creation_date: 2014-02-06T14:36:46Z [Term] id: FYPO:0003082 name: normal genetic imprinting at mating-type locus def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which genetic imprinting at the mating-type locus is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal genetic imprinting at mating-type locus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal genetic imprinting at mating-type locus during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000859 ! normal metabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071515 ! genetic imprinting at mating-type locus intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071515 ! genetic imprinting at mating-type locus relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-02-06T14:53:36Z [Term] id: FYPO:0003083 name: abnormal replication fork arrest at mating-type locus def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which replication fork arrest at the mating-type locus is abnormal." [PomBase:mah] synonym: "abnormal replication fork arrest at mating-type locus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal replication fork arrest at mating-type locus during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003088 ! abnormal replication fork arrest intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0011000 ! replication fork arrest at mating type locus intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0011000 ! replication fork arrest at mating type locus relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-02-06T15:11:09Z [Term] id: FYPO:0003084 name: abolished replication fork arrest at mating-type locus def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which replication fork arrest at the mating-type locus does not occur." [PomBase:mah] synonym: "abolished replication fork arrest at mating-type locus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "replication fork arrest at mating-type locus abolished" EXACT [PomBase:mah] synonym: "replication fork arrest at mating-type locus abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003083 ! abnormal replication fork arrest at mating-type locus is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0011000 ! replication fork arrest at mating type locus relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0011000 ! replication fork arrest at mating type locus created_by: midori creation_date: 2014-02-06T15:11:27Z [Term] id: FYPO:0003085 name: decreased replication fork arrest at mating-type locus def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which replication fork arrest at the mating-type locus occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased replication fork arrest at mating-type locus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased replication fork arrest at mating-type locus during vegetative growth" EXACT [PomBase:mah] synonym: "reduced replication fork arrest at mating-type locus" EXACT [PomBase:mah] is_a: FYPO:0003083 ! abnormal replication fork arrest at mating-type locus is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0011000 ! replication fork arrest at mating type locus relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0011000 ! replication fork arrest at mating type locus created_by: midori creation_date: 2014-02-06T15:11:41Z [Term] id: FYPO:0003086 name: normal chromatin binding def: "A molecular function phenotype in which occurrence of chromatin binding by a gene product (usually a protein) in a mutant is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000706 ! normal molecular function is_a: FYPO:0001092 ! binding phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0003682 ! chromatin binding intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0003682 ! chromatin binding relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-02-06T15:16:11Z [Term] id: FYPO:0003087 name: normal chromatin binding at mating-type region replication fork barrier def: "A molecular function phenotype in which occurrence of chromatin binding by a gene product (usually a protein) in a mutant is normal (i.e. indistinguishable from wild type) at a replication fork barrier in the mating-type region." [PomBase:mah] is_a: FYPO:0003086 ! normal chromatin binding intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0003682 ! chromatin binding intersection_of: occurs_at SO:0002021 ! mating_type_region_replication_fork_barrier intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0003682 ! chromatin binding relationship: occurs_at SO:0002021 ! mating_type_region_replication_fork_barrier relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-02-06T15:16:52Z [Term] id: FYPO:0003088 name: abnormal replication fork arrest def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which replication fork arrest is abnormal." [PomBase:mah] synonym: "abnormal replication fork arrest during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal replication fork arrest during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001334 ! regulation phenotype during vegetative growth is_a: FYPO:0001346 ! DNA metabolism phenotype during vegetative growth is_a: FYPO:0001363 ! abnormal metabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0043111 ! replication fork arrest intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0043111 ! replication fork arrest relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-02-06T15:39:06Z [Term] id: FYPO:0003089 name: abnormal replication fork arrest at rDNA repeats def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which replication fork arrest at sites within the eukaryotic rDNA repeat spacer is abnormal." [PomBase:mah] synonym: "abnormal replication fork arrest at rDNA repeats during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal replication fork arrest at rDNA repeats during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal replication fork arrest at ribosomal DNA repeats" EXACT [PomBase:mah] is_a: FYPO:0000641 ! abnormal chromosome organization is_a: FYPO:0001353 ! abnormal cellular component organization during vegetative growth is_a: FYPO:0003088 ! abnormal replication fork arrest intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0031582 ! replication fork arrest at rDNA repeats intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0031582 ! replication fork arrest at rDNA repeats relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-02-06T15:39:57Z [Term] id: FYPO:0003090 name: decreased replication fork arrest at rDNA repeats def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which replication fork arrest at abnormal replication fork arrest at sites within the eukaryotic rDNA repeat spacer occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased replication fork arrest at rDNA repeats during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased replication fork arrest at rDNA repeats during vegetative growth" EXACT [PomBase:mah] synonym: "decreased replication fork arrest at ribosomal DNA repeats" EXACT [PomBase:mah] synonym: "reduced replication fork arrest at rDNA repeats" EXACT [PomBase:mah] is_a: FYPO:0001722 ! decreased sodium export is_a: FYPO:0003089 ! abnormal replication fork arrest at rDNA repeats intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0031582 ! replication fork arrest at rDNA repeats intersection_of: inheres_in GO:0071436 ! sodium ion export relationship: happens_during GO:0031582 ! replication fork arrest at rDNA repeats relationship: inheres_in GO:0071436 ! sodium ion export created_by: midori creation_date: 2014-02-06T15:41:07Z [Term] id: FYPO:0003091 name: decreased chromatin binding at rDNA replication fork barrier def: "A molecular function phenotype in which occurrence of chromatin binding by a gene product (usually a protein) at a replication fork pausing site within the eukaryotic rDNA repeat spacer in a mutant is decreased. The affected gene product may be encoded by the mutated gene, or by a different gene, and may normally bind DNA, protein, or both in chromatin." [PomBase:mah] synonym: "decreased chromatin binding at ribosomal DNA replication fork barrier" EXACT [PomBase:mah] synonym: "reduced chromatin binding at rDNA replication fork barrier" EXACT [PomBase:mah] is_a: FYPO:0002577 ! decreased chromatin binding intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0003682 ! chromatin binding intersection_of: occurs_at SO:0001914 ! rDNA_replication_fork_barrier relationship: inheres_in GO:0003682 ! chromatin binding relationship: occurs_at SO:0001914 ! rDNA_replication_fork_barrier created_by: midori creation_date: 2014-02-06T15:46:03Z [Term] id: FYPO:0003092 name: decreased chromatin binding at mating-type region replication fork barrier def: "A molecular function phenotype in which occurrence of chromatin binding by a gene product (usually a protein) at a replication fork pausing site within the mating-type region in a mutant is decreased. The affected gene product may be encoded by the mutated gene, or by a different gene, and may normally bind DNA, protein, or both in chromatin." [PomBase:mah] synonym: "reduced chromatin binding at mating-type region replication fork barrier" EXACT [PomBase:mah] is_a: FYPO:0002577 ! decreased chromatin binding intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0003682 ! chromatin binding intersection_of: occurs_at SO:0002021 ! mating_type_region_replication_fork_barrier relationship: inheres_in GO:0003682 ! chromatin binding relationship: occurs_at SO:0002021 ! mating_type_region_replication_fork_barrier created_by: midori creation_date: 2014-02-06T15:48:12Z [Term] id: FYPO:0003093 name: increased Argonaute-associated RNA length def: "A phenotype in which small RNA molecules physically associated with the Argonaute protein (Ago1) are longer than normal." [PMID:24095277, PomBase:mah] synonym: "increased Argonaute-associated priRNA length" NARROW [PomBase:mah] synonym: "increased Argonaute-associated siRNA length" NARROW [PomBase:mah] synonym: "increased length of Ago1-associated RNA" NARROW [PomBase:mah] synonym: "increased length of Argonaute-associated RNA" EXACT [PomBase:mah] synonym: "increased length of Argonaute-associated small RNA" EXACT [PomBase:mah] is_a: FYPO:0001985 ! abnormal phenotype created_by: midori creation_date: 2014-02-13T15:11:35Z [Term] id: FYPO:0003094 name: decreased centromeric outer repeat transcript level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which RNAs transcribed from the centromere outer repeat region are present at lower levels than normal." [PMID:24095277, PomBase:mah] comment: This term encompasses both unprocessed RNA transcribed from the centromere outer repeat region and siRNAs derived by dicer-mediated processing of the primary transcripts. Use this term only for levels of RNA transcribed from endogenous centromere outer repeat sequences. For levels of RNA transcribed from an exogenous reporter gene placed in the outer repeat region, consider 'abnormal chromatin silencing at centromere outer repeat region' (FYPO:0002346). synonym: "decreased accumulation of centromeric outer repeat transcripts" RELATED [PomBase:mah] synonym: "decreased accumulation of centromeric outer repeat transcripts during vegetative growth" RELATED [PomBase:mah] synonym: "decreased accumulation of non-coding outer repeat transcripts" EXACT [PomBase:vw] synonym: "decreased centromere outer repeat transcript level" EXACT [PomBase:mah] synonym: "decreased centromeric outer repeat transcript level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased centromeric outer repeat transcript level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased centromeric outer repeat-derived transcript level" EXACT [PomBase:vw] synonym: "decreased level of centromeric outer repeat transcripts" EXACT [PomBase:mah] synonym: "reduced centromeric outer repeat transcript level" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards SO:0001905 ! regional_centromere_outer_repeat_transcript relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards SO:0001905 ! regional_centromere_outer_repeat_transcript created_by: midori creation_date: 2014-02-13T15:22:03Z [Term] id: FYPO:0003095 name: viable elongated vegetative cell, with progressive elongation def: "A cell morphology phenotype in which a vegetative cell is viable and longer than normal, and continues to become longer over successive generations. The cell also undergoes mitosis beginning when the cell is longer than normal." [PMID:24013504, PomBase:mah] comment: Note that progressive cell elongation usually results from DNA damage checkpoint activation. Consider also annotating to 'normal DNA damage checkpoint' (FYPO:0001705) or 'increased DNA damage checkpoint activation' (FYPO:0001707). synonym: "progressively elongating viable vegetative cell" EXACT [PomBase:mah] is_a: FYPO:0003481 ! viable elongated vegetative cell, elongated upon mitotic entry created_by: midori creation_date: 2014-02-19T10:34:57Z [Term] id: FYPO:0003096 name: decreased histone H3-K9 methylation at centromere outer repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which methylation of lysine at position 9 of histone H3 in centromere outer repeat regions occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased histone H3 K9 methylation at centromere outer repeat" EXACT [GO:0051567, PomBase:mah] synonym: "decreased histone H3-K9 methylation at centromere otr" EXACT [PomBase:mah] synonym: "decreased histone H3-K9 methylation at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H3-K9 methylation at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] synonym: "decreased histone H3-K9 methylation at centromeric dg repeats" NARROW [PMID:24095277, PomBase:mah] synonym: "decreased histone H3-K9 methylation at centromeric outer repeat" EXACT [PomBase:mah] synonym: "decreased histone H3-K9 methylation at pericentric region" RELATED [PomBase:mah] synonym: "decreased histone H3-K9 methylation at pericentromeric region" RELATED [PomBase:mah] synonym: "decreased histone H3K9me at centromere outer repeat" EXACT [GO:0051567, PomBase:mah] synonym: "decreased histone lysine H3 K9 methylation at centromere outer repeat" EXACT [GO:0051567, PomBase:mah] synonym: "reduced histone H3-K9 methylation at centromere outer repeat" EXACT [PomBase:mah] is_a: FYPO:0000458 ! abnormal histone H3-K9 methylation is_a: FYPO:0000872 ! decreased histone H3-K9 methylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051567 ! histone H3-K9 methylation intersection_of: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051567 ! histone H3-K9 methylation relationship: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region created_by: midori creation_date: 2014-02-13T15:55:37Z [Term] id: FYPO:0003097 name: abolished histone H3-K9 methylation at centromere outer repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which methylation of lysine at position 9 of histone H3 in centromere outer repeat regions does not occur." [PomBase:mah] synonym: "abolished histone H3 K9 methylation at centromere outer repeat" EXACT [GO:0051567, PomBase:mah] synonym: "abolished histone H3-K9 methylation at centromere otr" EXACT [PomBase:mah] synonym: "abolished histone H3-K9 methylation at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished histone H3-K9 methylation at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] synonym: "abolished histone H3-K9 methylation at centromeric dg repeats" NARROW [PMID:24095277, PomBase:mah] synonym: "abolished histone H3-K9 methylation at centromeric outer repeat" EXACT [PomBase:mah] synonym: "abolished histone H3-K9 methylation at pericentric region" RELATED [PomBase:mah] synonym: "abolished histone H3-K9 methylation at pericentromeric region" RELATED [PomBase:mah] synonym: "abolished histone H3K9me at centromere outer repeat" EXACT [GO:0051567, PomBase:mah] synonym: "abolished histone lysine H3 K9 methylation at centromere outer repeat" EXACT [GO:0051567, PomBase:mah] synonym: "histone H3-K9 methylation at centromere outer repeat abolished" EXACT [PomBase:mah] is_a: FYPO:0002566 ! abolished histone H3-K9 methylation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region intersection_of: towards GO:0051567 ! histone H3-K9 methylation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region relationship: towards GO:0051567 ! histone H3-K9 methylation created_by: midori creation_date: 2014-02-13T15:57:50Z [Term] id: FYPO:0003098 name: abnormal heterochromatin assembly at centromere outer repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which heterochromatin assembly is abnormal in centromere outer repeat regions. Heterochromatin assembly is the assembly of chromatin into a compact and highly condensed form that is often, but not always, transcriptionally silent." [GO:0031507, PomBase:mah] synonym: "abnormal heterochromatin assembly at centromere outer repeat at centromere otr" EXACT [PomBase:mah] synonym: "abnormal heterochromatin assembly at centromere outer repeat at centromeric outer repeat" EXACT [PomBase:mah] synonym: "abnormal heterochromatin assembly at centromere outer repeat at pericentric region" RELATED [PomBase:mah] synonym: "abnormal heterochromatin assembly at centromere outer repeat at pericentromeric region" RELATED [PomBase:mah] synonym: "abnormal heterochromatin assembly at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal heterochromatin assembly at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal heterochromatin formation at centromere outer repeat" EXACT [GO:0031507, PomBase:mah] is_a: FYPO:0003044 ! abnormal heterochromatin assembly intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0031507 ! heterochromatin assembly intersection_of: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0031507 ! heterochromatin assembly relationship: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-02-13T16:00:00Z [Term] id: FYPO:0003099 name: normal heterochromatin assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which heterochromatin assembly is normal (i.e. indistinguishable from wild type). Heterochromatin assembly is the assembly of chromatin into a compact and highly condensed form that is often, but not always, transcriptionally silent." [GO:0031507, PomBase:mah] synonym: "normal heterochromatin assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal heterochromatin assembly during vegetative growth" EXACT [PomBase:mah] synonym: "normal heterochromatin formation" EXACT [GO:0031507, PomBase:mah] is_a: FYPO:0002892 ! normal heterochromatin organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0031507 ! heterochromatin assembly intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0031507 ! heterochromatin assembly relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-02-13T16:01:35Z [Term] id: FYPO:0003100 name: normal heterochromatin assembly at protein coding gene def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which heterochromatin assembly is normal (i.e. indistinguishable from wild type) in regions containing protein-coding genes. Heterochromatin assembly is the assembly of chromatin into a compact and highly condensed form that is often, but not always, transcriptionally silent." [GO:0031507, PMID:24095277, PomBase:mah] synonym: "normal heterochromatin assembly at protein coding gene during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal heterochromatin assembly at protein coding gene during vegetative growth" EXACT [PomBase:mah] synonym: "normal heterochromatin assembly at protein-coding gene" EXACT [PomBase:mah] synonym: "normal heterochromatin formation at protein coding gene" EXACT [GO:0031507, PomBase:mah] is_a: FYPO:0003099 ! normal heterochromatin assembly intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0031507 ! heterochromatin assembly intersection_of: occurs_at SO:0001217 ! protein_coding_gene intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0031507 ! heterochromatin assembly relationship: occurs_at SO:0001217 ! protein_coding_gene relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-02-13T16:02:53Z [Term] id: FYPO:0003101 name: decreased heterochromatin assembly at protein coding gene def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which heterochromatin assembly occurs to a lower extent than normal in regions containing protein-coding genes. Heterochromatin assembly is the assembly of chromatin into a compact and highly condensed form that is often, but not always, transcriptionally silent." [GO:0031507, PMID:24095277, PomBase:mah] synonym: "decreased heterochromatin assembly at protein coding gene during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased heterochromatin assembly at protein coding gene during vegetative growth" EXACT [PomBase:mah] synonym: "decreased heterochromatin assembly at protein-coding gene" EXACT [PomBase:mah] synonym: "decreased heterochromatin formation at protein coding gene" EXACT [GO:0031507, PomBase:mah] synonym: "reduced heterochromatin assembly at protein coding gene" EXACT [PomBase:mah] is_a: FYPO:0001352 ! abnormal chromatin organization during vegetative growth is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0031507 ! heterochromatin assembly intersection_of: occurs_at SO:0001217 ! protein_coding_gene relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0031507 ! heterochromatin assembly relationship: occurs_at SO:0001217 ! protein_coding_gene created_by: midori creation_date: 2014-02-13T16:17:23Z [Term] id: FYPO:0003102 name: increased histone H3-K9 methylation at protein-coding gene def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which methylation of lysine at position 9 of histone H3 in regions containing protein-coding genes occurs to a greater extent than normal." [PomBase:mah] synonym: "increased histone H3 K9 methylation at protein-coding gene" EXACT [GO:0051567, PomBase:mah] synonym: "increased histone H3-K9 methylation at protein coding gene" EXACT [PomBase:mah] synonym: "increased histone H3-K9 methylation at protein-coding gene during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H3-K9 methylation at protein-coding gene during vegetative growth" EXACT [PomBase:mah] synonym: "increased histone H3K9me at protein-coding gene" EXACT [GO:0051567, PomBase:mah] synonym: "increased histone lysine H3 K9 methylation at protein-coding gene" EXACT [GO:0051567, PomBase:mah] is_a: FYPO:0000871 ! increased histone H3-K9 methylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051567 ! histone H3-K9 methylation intersection_of: occurs_at SO:0001217 ! protein_coding_gene relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051567 ! histone H3-K9 methylation relationship: occurs_at SO:0001217 ! protein_coding_gene created_by: midori creation_date: 2014-02-13T16:19:52Z [Term] id: FYPO:0003103 name: decreased mRNA-derived small RNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of small RNA (such as siRNA) derived from mRNA transcripts measured in a cell is lower than normal." [PMID:24095277, PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased accumulation of mRNA-derived small RNAs" RELATED [PomBase:vw] synonym: "decreased mRNA-derived small RNA accumulation" RELATED [PomBase:mah] synonym: "decreased mRNA-derived small RNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased mRNA-derived small RNA level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein-coding gene-derived small RNA level" RELATED [PomBase:mah] synonym: "reduced mRNA-derived small RNA level" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth created_by: midori creation_date: 2014-02-13T16:36:11Z [Term] id: FYPO:0003104 name: increased mRNA-derived small RNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of small RNA (such as siRNA) derived from mRNA transcripts measured in a cell is greater than normal." [PMID:24095277, PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased accumulation of mRNA-derived small RNAs" RELATED [PomBase:vw] synonym: "increased mRNA-derived small RNA accumulation" RELATED [PomBase:mah] synonym: "increased mRNA-derived small RNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased mRNA-derived small RNA level during vegetative growth" EXACT [PomBase:mah] synonym: "increased protein-coding gene-derived small RNA level" RELATED [PomBase:mah] is_a: FYPO:0000825 ! increased RNA level during vegetative growth created_by: midori creation_date: 2014-02-13T16:38:10Z [Term] id: FYPO:0003105 name: increased transposable element-derived small RNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of small RNA (such as siRNA) derived from transposable element transcripts measured in a cell is greater than normal." [PMID:24095277, PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased accumulation of transposable element-derived small RNAs" RELATED [PomBase:vw] synonym: "increased transposable element-derived small RNA accumulation" RELATED [PomBase:mah] synonym: "increased transposable element-derived small RNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased transposable element-derived small RNA level during vegetative growth" EXACT [PomBase:mah] synonym: "increased transposon-derived small RNA level" EXACT [PomBase:mah] is_a: FYPO:0003558 ! increased repeat element RNA level created_by: midori creation_date: 2014-02-13T16:42:33Z [Term] id: FYPO:0003106 name: stable shortened telomeres def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells form telomeres that are shorter than normal, and that remain at a consistent length over successive generations." [PMID:24013504, PomBase:mah] synonym: "stable decreased telomere length" EXACT [PomBase:mah] synonym: "stably shortened telomeres" EXACT [PomBase:mah] is_a: FYPO:0002239 ! shortened telomeres created_by: midori creation_date: 2014-02-19T11:03:54Z [Term] id: FYPO:0003107 name: progressively shortening telomeres def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells form telomeres that are shorter than normal, and that continue to decrease in length over successive generations." [PMID:24013504, PomBase:mah] synonym: "progressively decreasing telomere length" EXACT [PomBase:mah] is_a: FYPO:0002239 ! shortened telomeres created_by: midori creation_date: 2014-02-19T11:05:13Z [Term] id: FYPO:0003108 name: abnormal protein localization to telomere def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the telomere of a chromosome is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found at the telomere and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to chromosome, telomeric region" EXACT [GO:0070198, PomBase:mah] synonym: "abnormal protein localisation to telomere" EXACT [PomBase:mah] synonym: "abnormal protein localization to chromosome, telomeric region" EXACT [GO:0070198, PomBase:mah] synonym: "abnormal protein localization to telomere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein localization to telomere during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002838 ! abnormal protein localization to chromosome intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0070198 ! protein localization to chromosome, telomeric region intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0070198 ! protein localization to chromosome, telomeric region relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-02-19T11:07:53Z [Term] id: FYPO:0003109 name: abolished protein localization to telomere def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the telomere of a chromosome does not occur." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to chromosome, telomeric region" EXACT [GO:0070198, PomBase:mah] synonym: "abolished protein localisation to telomere" EXACT [PomBase:mah] synonym: "abolished protein localization to chromosome, telomeric region" EXACT [GO:0070198, PomBase:mah] synonym: "abolished protein localization to telomere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to telomere during vegetative growth" EXACT [PomBase:mah] synonym: "protein absent from telomere" RELATED [PomBase:mah] synonym: "protein localization to telomere abolished" EXACT [PomBase:mah] is_a: FYPO:0002841 ! abolished protein localization to chromosome is_a: FYPO:0003108 ! abnormal protein localization to telomere intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0070198 ! protein localization to chromosome, telomeric region relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0070198 ! protein localization to chromosome, telomeric region created_by: midori creation_date: 2014-02-19T11:08:34Z [Term] id: FYPO:0003110 name: sensitive to caffeine and rapamycin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to a combination of caffeine and rapamycin. Cells stop growing (and may die) at concentrations of caffeine and rapamycin that allows wild type cells to grow." [PMID:23551936, PomBase:mah] synonym: "hypersensitive to caffeine and rapamycin" EXACT [PomBase:mah] synonym: "sensitive to caffeine and rapamycin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to caffeine and rapamycin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth created_by: midori creation_date: 2014-02-19T11:21:00Z [Term] id: FYPO:0003111 name: abnormal ubiquitinyl hydrolase activity def: "A molecular function phenotype in which the observed rate of ubiquitinyl hydrolase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0036459 ! ubiquitinyl hydrolase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0036459 ! ubiquitinyl hydrolase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-02-19T11:36:19Z [Term] id: FYPO:0003112 name: increased ubiquitinyl hydrolase activity def: "A molecular function phenotype in which the observed rate of ubiquitinyl hydrolase activity is increased." [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0003111 ! abnormal ubiquitinyl hydrolase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0036459 ! ubiquitinyl hydrolase activity relationship: inheres_in GO:0036459 ! ubiquitinyl hydrolase activity created_by: midori creation_date: 2014-02-19T11:36:28Z [Term] id: FYPO:0003113 name: resistance to sodium nitroprusside def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of sodium nitroprusside than normal." [PomBase:mah] synonym: "resistance to sodium nitroprusside during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to sodium nitroprusside during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to sodium nitroprusside" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:29321 ! sodium nitroprusside relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:29321 ! sodium nitroprusside created_by: midori creation_date: 2014-02-19T11:38:18Z [Term] id: FYPO:0003114 name: increased cellular nitric oxide level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of nitric oxide measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular nitric oxide level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular nitric oxide level during vegetative growth" EXACT [PomBase:mah] synonym: "increased cellular NO level" EXACT [CHEBI:16480] synonym: "increased nitric oxide accumulation" RELATED [PomBase:mah] is_a: FYPO:0003004 ! increased cellular reactive oxygen species level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:16480 ! nitric oxide relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:16480 ! nitric oxide created_by: midori creation_date: 2014-02-19T11:43:42Z [Term] id: FYPO:0003115 name: resistance to L-methionine (R)-S-oxide def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of L-methionine (R)-S-oxide than normal." [PomBase:mah] synonym: "resistance to L-methionine (R)-S-oxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to L-methionine (R)-S-oxide during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to L-methionine (R)-S-oxide" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:49032 ! L-methionine (R)-S-oxide relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:49032 ! L-methionine (R)-S-oxide created_by: midori creation_date: 2014-02-19T11:45:51Z [Term] id: FYPO:0003116 name: sensitive to plumbagin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to plumbagin. Cells stop growing (and may die) at a concentration of plumbagin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to plumbagin" EXACT [PomBase:mah] synonym: "sensitive to plumbagin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to plumbagin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:8273 ! plumbagin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:8273 ! plumbagin created_by: midori creation_date: 2014-02-19T14:29:40Z [Term] id: FYPO:0003117 name: increased cellular reactive oxygen species level during cellular response to plumbagin def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of reactive oxygen species (ROS) measured in a cell is higher than normal during a cellular response to plumbagin." [PomBase:mah] synonym: "increased cellular reactive oxygen species accumulation during cellular response to plumbagin" RELATED [PomBase:mah] synonym: "increased cellular reactive oxygen species level during cellular response to plumbagin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular reactive oxygen species level during cellular response to plumbagin during vegetative growth" EXACT [PomBase:mah] synonym: "increased cellular ROS accumulation during cellular response to plumbagin" RELATED [PomBase:mah] synonym: "increased cellular ROS level during cellular response to plumbagin" EXACT [PomBase:mah] synonym: "increased ROS accumulation during cellular response to plumbagin" RELATED [PomBase:al] is_a: FYPO:0003004 ! increased cellular reactive oxygen species level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: exists_during GO:1902709 ! cellular response to plumbagin intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:26523 ! reactive oxygen species relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: exists_during GO:1902709 ! cellular response to plumbagin relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:26523 ! reactive oxygen species created_by: midori creation_date: 2014-02-19T14:31:55Z [Term] id: FYPO:0003118 name: normal cellular reactive oxygen species level during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of reactive oxygen species (ROS) measured in the cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular reactive oxygen species level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular ROS level" EXACT [PomBase:mah] synonym: "normal level of reactive oxygen species in cell" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:26523 ! reactive oxygen species relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:26523 ! reactive oxygen species created_by: midori creation_date: 2014-02-19T14:36:02Z [Term] id: FYPO:0003119 name: increased nuclear polyadenylated mRNA level during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of polyadenylated messenger RNA (mRNA) measured in the nucleus is higher than normal. Total mRNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased nuclear poly(A)+ mRNA level during vegetative growth" EXACT [PomBase:vw] synonym: "increased nuclear polyadenylated messenger RNA level during vegetative growth" EXACT [PomBase:mah] synonym: "increased nuclear polyadenylated mRNA accumulation during vegetative growth" RELATED [PomBase:mah] synonym: "increased nuclear polyadenylated mRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased nuclear polyadenylated mRNA transcript level during vegetative growth" EXACT [PomBase:vw] synonym: "nuclear poly(A)+ mRNA accumulation" RELATED [PomBase:vw] synonym: "nuclear poly-A mRNA accumulation" RELATED [PomBase:vw] is_a: FYPO:0000911 ! increased nuclear RNA level during vegetative growth is_a: FYPO:0002936 ! increased mRNA level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005634 ! nucleus intersection_of: towards SO:0000871 ! polyadenylated_mRNA relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005634 ! nucleus relationship: towards SO:0000871 ! polyadenylated_mRNA created_by: midori creation_date: 2014-02-19T15:21:49Z [Term] id: FYPO:0003120 name: decreased transcription during glucose starvation def: "A cellular process phenotype in which transcription occurs to a lower extent than normal when the cell is subject to glucose starvation. All genes, or a specific subset of genes, may be affected." [PomBase:mah] comment: Use this term if there is evidence, such as labeled nucleotide incorporation, showing that transcription rather than RNA stability is affected; otherwise, use 'decreased RNA level' (FYPO:0000826). synonym: "decreased transcription during cellular response to glucose starvation" EXACT [PomBase:mah] synonym: "decreased transcription during glucose depletion" EXACT [PomBase:vw] synonym: "decreased transcription during glucose deprivation" EXACT [PomBase:vw] synonym: "decreased transcription in response to glucose starvation" EXACT [PomBase:mah, PomBase:vw] synonym: "reduced transcription during glucose starvation" EXACT [PomBase:mah] is_a: FYPO:0002876 ! decreased transcription intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0042149 ! cellular response to glucose starvation intersection_of: inheres_in GO:0006351 ! transcription, DNA-templated relationship: happens_during GO:0042149 ! cellular response to glucose starvation relationship: inheres_in GO:0006351 ! transcription, DNA-templated created_by: midori creation_date: 2014-02-19T15:29:30Z [Term] id: FYPO:0003121 name: normal rate of homologous chromosome pairing at cis-acting homologous chromosome pairing region def: "A cellular process phenotype in which the rate, or speed, of homologous chromosome pairing during meiosis (synapsis) is normal (i.e. indistinguishable from wild type) at a cis-acting homologous chromosome pairing region such as the sme2 locus." [PMID:22582262, PMID:23117617, PMID:24173580, PomBase:mah] synonym: "normal rate of homologous chromosome pairing at meiosis at cis-acting homologous chromosome pairing region" EXACT [GO:0007129] synonym: "normal rate of homologous chromosome pairing at sme2 locus" NARROW [PomBase:mah] synonym: "normal rate of synapsis at cis-acting homologous chromosome pairing region" EXACT [GO:0007129] is_a: FYPO:0003051 ! normal homologous chromosome pairing at cis-acting homologous chromosome pairing region created_by: midori creation_date: 2014-02-19T15:39:51Z [Term] id: FYPO:0003122 name: decreased protein autophosphorylation during cellular response to DNA damage def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of autophosphorylation of one or more specific proteins, or of specific protein sites, is decreased during a cellular response to DNA damage." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein autophosphorylation during cellular response to DNA damage during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein autophosphorylation during cellular response to DNA damage during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein autophosphorylation during cellular response to DNA damage" EXACT [PomBase:mah] is_a: FYPO:0002897 ! decreased protein phosphorylation during cellular response to DNA damage is_a: FYPO:0003298 ! decreased protein autophosphorylation during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0006974 ! cellular response to DNA damage stimulus intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0046777 ! protein autophosphorylation relationship: happens_during GO:0006974 ! cellular response to DNA damage stimulus relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0046777 ! protein autophosphorylation created_by: midori creation_date: 2014-02-19T15:58:59Z [Term] id: FYPO:0003123 name: abolished protein localization to nuclear periphery during cellular response to heat def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nuclear periphery is abolished during a cellular response to heat." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to nuclear periphery during cellular response to heat" EXACT [PomBase:mah] synonym: "abolished protein localization to nuclear periphery during cellular response to heat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to nuclear periphery during cellular response to heat during vegetative growth" EXACT [PomBase:mah] synonym: "protein localization to nuclear periphery abolished during cellular response to heat" EXACT [PomBase:mah] is_a: FYPO:0002568 ! abolished protein localization to nuclear periphery intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0034605 ! cellular response to heat intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1990139 ! protein localization to nuclear periphery relationship: during GO:0034605 ! cellular response to heat relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1990139 ! protein localization to nuclear periphery created_by: midori creation_date: 2014-02-19T16:07:20Z [Term] id: FYPO:0003124 name: abnormal cytoplasmic translation def: "A metabolism phenotype observed in the vegetative growth phase of the life cycle in which translation in the cytoplasm is abnormal. Translation is the synthesis of a protein using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain." [GO:0002183, PomBase:mah] comment: Note that this term should be used only when an experiment measures protein synthesis directly, e.g. by measuring incorporation of a radiolabeled amino acid. Consider annotating to 'altered protein level' (FYPO:0000834) or one of its descendants. synonym: "abnormal cytoplasmic protein biosynthesis" EXACT [GO:0006412, PomBase:mah] synonym: "abnormal cytoplasmic protein synthesis" EXACT [GO:0006412, PomBase:mah] synonym: "abnormal cytoplasmic translation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal cytoplasmic translation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001797 ! abnormal translation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0002180 ! 5-lipoxygenase complex intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0002180 ! 5-lipoxygenase complex relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-02-19T16:10:41Z [Term] id: FYPO:0003125 name: decreased cytoplasmic translational initiation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of translational initiation in the cytoplasm is decreased." [PomBase:mah] comment: Note that this term should be used only when an experiment measures the initiation of protein synthesis directly, e.g. by ribosome profiling. Consider annotating to 'decreased protein level' (FYPO:0000835) or one of its descendants. synonym: "decreased cytoplasmic translational initiation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cytoplasmic translational initiation during vegetative growth" EXACT [PomBase:mah] synonym: "reduced cytoplasmic translational initiation" EXACT [PomBase:mah] is_a: FYPO:0003124 ! abnormal cytoplasmic translation is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0002183 ! cytoplasmic translational initiation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0002183 ! cytoplasmic translational initiation created_by: midori creation_date: 2014-02-19T16:10:56Z [Term] id: FYPO:0003126 name: post-anaphase array absent from cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the cell does not contain a detectable post-anaphase array of microtubules." [PMID:24006493, PMID:9601091, PomBase:mah] synonym: "absent post-anaphase array" EXACT [PomBase:mah] synonym: "PAA absent from cell" EXACT [PMID:9601091] synonym: "post-anaphase array absent from cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "post-anaphase array absent from cell during vegetative growth" EXACT [PomBase:mah] synonym: "post-anaphase microtubule array absent from cell" EXACT [PomBase:mah] is_a: FYPO:0004316 ! abnormal post-anaphase array is_a: PATO:0002000 ! lacks all parts of type intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards GO:1990295 ! post-anaphase microtubule array relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards GO:1990295 ! post-anaphase microtubule array created_by: midori creation_date: 2014-02-19T16:39:51Z [Term] id: FYPO:0003127 name: decreased cellular nitric oxide level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of nitric oxide measured in a cell is lower than normal." [PomBase:mah] synonym: "decreased cellular nitric oxide level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular nitric oxide level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased cellular NO level" EXACT [CHEBI:16480] synonym: "decreased nitric oxide accumulation" RELATED [PomBase:mah] synonym: "reduced cellular nitric oxide level" EXACT [PomBase:mah] is_a: FYPO:0002780 ! decreased cellular reactive oxygen species level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:16480 ! nitric oxide relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:16480 ! nitric oxide created_by: midori creation_date: 2014-02-20T14:02:44Z [Term] id: FYPO:0003128 name: inviable elongated mononucleate aseptate vegetative cell with cell cycle arrest in mitotic M phase def: "A cell morphology phenotype in which a vegetative cell is inviable contains one nucleus, has no septum, is longer than normal, and progress through the mitotic cell cycle is arrested in M phase." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "elongated inviable mononucleate aseptate cell with mitotic cell cycle arrest in M phase during vegetative growth" EXACT [PomBase:mah] synonym: "elongated inviable mononucleate aseptate vegetative cell with cell cycle arrest in mitotic M phase" EXACT [PomBase:mah] synonym: "essential; elongated mononucleate aseptate vegetative cell with cell cycle arrest in mitotic M phase" RELATED [PomBase:mah] synonym: "inviable elongated mononucleate aseptate vegetative cell with cell cycle arrest in mitosis" EXACT [PomBase:mah] synonym: "inviable elongated mononucleate aseptate vegetative cell with mitotic cell cycle arrest in M phase" EXACT [PomBase:mah] synonym: "inviable elongated mononucleate aseptate vegetative cell with mitotic nuclear division arrest" EXACT [PomBase:vw] synonym: "mitotic cell cycle arrest in M-phase with elongated inviable mononucleate aseptate cell" EXACT [PomBase:vw] synonym: "mitotic M-phase arrested elongated inviable mononucleate aseptate vegetative cell" EXACT [PomBase:mah] synonym: "nuclear division arrest without septation (elongated cell)" EXACT [PomBase:vw] is_a: FYPO:0000839 ! inviable elongated mononucleate aseptate cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000060 ! mononucleate vegetative cell intersection_of: has_part FYPO:0000608 ! abnormal cell cycle arrest in mitotic M phase intersection_of: has_part FYPO:0000949 ! aseptate intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000060 ! mononucleate vegetative cell relationship: has_part FYPO:0000608 ! abnormal cell cycle arrest in mitotic M phase relationship: has_part FYPO:0000949 ! aseptate relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2014-02-20T14:09:34Z [Term] id: FYPO:0003129 name: loss of punctate nuclear protein localization during cellular response to ionizing radiation def: "A cell phenotype in which a protein that is normally localized to discrete regions in the nucleus, visible as foci or dots by fluorescence microscopy, is abnormally localized such that dots cannot be observed during a cellular response to ionizing radiation." [PomBase:mah] synonym: "abolished punctate nuclear protein localization during cellular response to ionizing radiation" EXACT [PomBase:mah] synonym: "loss of punctate nuclear protein localisation during cellular response to ionising radiation" EXACT [PomBase:mah] synonym: "loss of punctate nuclear protein localization during cellular response to ionizing radiation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "loss of punctate nuclear protein localization during cellular response to ionizing radiation during vegetative growth" EXACT [PomBase:mah] synonym: "loss of punctate nuclear protein localization during cellular response to IR" EXACT [PomBase:al] is_a: FYPO:0002624 ! decreased punctate nuclear protein localization created_by: midori creation_date: 2014-02-20T14:20:27Z [Term] id: FYPO:0003130 name: advanced mitotic G1 phase entry during cellular response to ionizing radiation def: "A cellular process phenotype in which entry into the G1 phase of the mitotic cell cycle (exit from mitosis) begins earlier than normal during a cellular response to ionizing radiation." [PomBase:mah] synonym: "accelerated entry into G1 during cellular response to ionizing radiation" RELATED [PomBase:al] synonym: "advanced exit from mitosis during cellular response to ionizing radiation" EXACT [PomBase:mah] synonym: "advanced mitotic G1 phase entry during cellular response to ionizing radiation during vegetative growth" EXACT [PomBase:mah] synonym: "advanced mitotic G1 phase entry during cellular response to IR" EXACT [PomBase:al] synonym: "advanced mitotic G1 progression during cellular response to ionizing radiation" RELATED [PomBase:mah] synonym: "mitotic cell cycle advance in G1 during cellular response to ionizing radiation" RELATED [PomBase:mah] synonym: "premature exit from mitosis during cellular response to ionizing radiation" EXACT [PomBase:mah] synonym: "premature mitotic G1 phase entry during cellular response to ionizing radiation" EXACT [PomBase:mah] is_a: FYPO:0000828 ! advanced mitotic G1 phase entry intersection_of: PATO:0000694 ! premature intersection_of: happens_during GO:0071479 ! cellular response to ionizing radiation intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0010458 ! exit from mitosis relationship: happens_during GO:0071479 ! cellular response to ionizing radiation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0010458 ! exit from mitosis created_by: midori creation_date: 2014-02-20T14:24:36Z [Term] id: FYPO:0003131 name: normal protein phosphorylation during cellular response to ionizing radiation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins is normal (i.e. indistinguishable from wild type) during a cellular response to ionizing radiation." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein phosphorylation during cellular response to ionizing radiation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein phosphorylation during cellular response to ionizing radiation during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein phosphorylation during cellular response to IR" EXACT [PomBase:al] is_a: FYPO:0000776 ! normal protein phosphorylation during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0071479 ! cellular response to ionizing radiation intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0071479 ! cellular response to ionizing radiation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-02-20T14:27:11Z [Term] id: FYPO:0003132 name: normal punctate nuclear localization during cellular response to ionizing radiation def: "A cell phenotype in which a gene product is normally localized to discrete regions in the nucleus (i.e. its localization is indistinguishable from wild type), visible as foci or dots by fluorescence microscopy, during a cellular response to ionizing radiation." [PomBase:mah] synonym: "normal punctate nuclear localisation during cellular response to ionising radiation" RELATED [PomBase:mah] synonym: "normal punctate nuclear localization during cellular response to ionizing radiation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal punctate nuclear localization during cellular response to ionizing radiation during vegetative growth" EXACT [PomBase:mah] synonym: "normal punctate nuclear localization during cellular response to IR" EXACT [PomBase:al] is_a: FYPO:0000644 ! normal protein localization during vegetative growth created_by: midori creation_date: 2014-02-20T14:29:03Z [Term] id: FYPO:0003133 name: galactomannan absent from cell wall def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of galactomannan measured in the cell wall is too low to detect." [PomBase:mah] synonym: "galactomannan absent from cell surface" RELATED [PomBase:al] synonym: "galactomannan absent from cell wall during mitotic cell cycle" RELATED [PomBase:mah] synonym: "galactomannan absent from cell wall during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001209 ! polysaccharide absent from cell is_a: FYPO:0002265 ! decreased cell wall galactomannan level intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0009277 ! fungal-type cell wall intersection_of: towards CHEBI:27680 ! galactomannan relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0009277 ! fungal-type cell wall relationship: towards CHEBI:27680 ! galactomannan created_by: midori creation_date: 2014-02-20T14:45:12Z [Term] id: FYPO:0003134 name: increased cell wall alpha-glucan level during cellular response to calcium starvation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of alpha-D-glucan measured in the cell wall is greater than normal during a cellular response to calcium starvation." [PomBase:mah] synonym: "increased cell wall alpha-D-glucan level during cellular response to calcium starvation" EXACT [CHEBI:22385, PomBase:mah] synonym: "increased cell wall alpha-glucan accumulation during cellular response to calcium starvation" RELATED [PomBase:mah] synonym: "increased cell wall alpha-glucan level during cellular response to calcium starvation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cell wall alpha-glucan level during cellular response to calcium starvation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001084 ! increased cell wall alpha-glucan level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: exists_during GO:0072732 ! cellular response to calcium ion starvation intersection_of: inheres_in GO:0009277 ! fungal-type cell wall intersection_of: towards CHEBI:22385 ! alpha-D-glucan relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: exists_during GO:0072732 ! cellular response to calcium ion starvation relationship: inheres_in GO:0009277 ! fungal-type cell wall relationship: towards CHEBI:22385 ! alpha-D-glucan created_by: midori creation_date: 2014-02-20T14:46:18Z [Term] id: FYPO:0003135 name: normal agglutination def: "A cell adhesion phenotype in which cells adhere to other cells of compatible mating type normally (i.e. agglutination is indistinguishable from wild type)." [PomBase:mah] synonym: "normal agglutination involved in conjugation with cellular fusion" EXACT [GO:0000752] is_a: FYPO:0000627 ! normal cellular process intersection_of: PATO:0000001 ! quality intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards GO:0000752 ! agglutination involved in conjugation with cellular fusion relationship: qualifier PATO:0000461 ! normal relationship: towards GO:0000752 ! agglutination involved in conjugation with cellular fusion created_by: midori creation_date: 2014-02-20T14:51:35Z [Term] id: FYPO:0003136 name: excess plasma membrane present def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells contain more plasma membrane than normal. Excess plasma membrane may appear as bubble-like structures inside the cell, and may be concentrated in the mating projection during conjugation." [PMID:19627505, PomBase:mah] synonym: "excess mating projection membrane present" NARROW [GO:0070250, PomBase:al, PomBase:vw] synonym: "excess plasma membrane present during mitotic cell cycle" RELATED [PomBase:mah] synonym: "excess plasma membrane present during vegetative growth" EXACT [PomBase:mah] synonym: "internal membrane bubbles present" RELATED [PMID:19627505, PomBase:vw] is_a: FYPO:0003278 ! abnormal plasma membrane is_a: PATO:0002002 ! has extra parts of type intersection_of: PATO:0002002 ! has extra parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0005886 ! plasma membrane relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0005886 ! plasma membrane created_by: midori creation_date: 2014-02-26T10:31:56Z [Term] id: FYPO:0003137 name: normal mitotic spindle pole body def: "A physical cellular phenotype in which the mitotic spindle pole bodies are normal (i.e. indistinguishable from wild type) with respect to structure, composition, location, and orientation." [PomBase:mah] synonym: "normal mitotic spindle pole body during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal spindle pole body during mitosis" EXACT [PomBase:vw] synonym: "normal spindle pole body during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001313 ! normal subcellular component during vegetative growth intersection_of: PATO:0001241 ! physical object quality intersection_of: exists_during GO:0007067 ! mitotic nuclear division intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0044732 ! mitotic spindle pole body intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0007067 ! mitotic nuclear division relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0044732 ! mitotic spindle pole body relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-02-26T10:41:05Z [Term] id: FYPO:0003138 name: abnormal ascospore wall morphology def: "A physical cellular phenotype in which the size, shape, or structure of the ascospore wall is abnormal." [PomBase:mah] synonym: "abnormal spore wall morphology" EXACT [PomBase:mah] synonym: "abnormal spore wall organization" RELATED [PomBase:vw] is_a: FYPO:0002947 ! abnormal cell wall morphology intersection_of: PATO:0000051 ! morphology intersection_of: inheres_in GO:0005619 ! ascospore wall intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0005619 ! ascospore wall relationship: output_of FYPO:0000580 ! abnormal ascospore wall biogenesis relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-02-26T11:13:35Z [Term] id: FYPO:0003139 name: abnormal sporulation resulting in formation of ascus containing anucleate spores def: "A sporulation phenotype that results in the formation of an ascus that contains spore-like bodies that do not contain nuclei." [PMID:8203159, PomBase:mah, PomBase:vw] synonym: "abnormal ascospore formation resulting in formation ascus containing anucleate spores" EXACT [GO:0030437, PomBase:mah] synonym: "abnormal sporulation resulting in formation of asci containing anucleate spores" RELATED [PomBase:mah] is_a: FYPO:0000121 ! abnormal sporulation created_by: midori creation_date: 2014-02-26T11:20:06Z [Term] id: FYPO:0003140 name: decreased protein tyrosine phosphorylation during cellular response to heat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of tyrosine residues in one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal during a cellular response to heat." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased peptidyl-tyrosine phosphorylation during cellular response to heat" EXACT [GO:0018108, PomBase:mah] synonym: "decreased protein tyrosine phosphorylation during cellular response to heat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein tyrosine phosphorylation during cellular response to heat during vegetative growth" EXACT [PomBase:mah] synonym: "decreased tyrosine phosphorylation during cellular response to heat" EXACT [PomBase:al] synonym: "reduced protein tyrosine phosphorylation during cellular response to heat" EXACT [PomBase:mah] is_a: FYPO:0002375 ! decreased protein tyrosine phosphorylation is_a: FYPO:0004173 ! decreased protein phosphorylation during cellular response to heat intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0034605 ! cellular response to heat intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0018108 ! peptidyl-tyrosine phosphorylation relationship: happens_during GO:0034605 ! cellular response to heat relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0018108 ! peptidyl-tyrosine phosphorylation created_by: midori creation_date: 2014-02-26T11:22:56Z [Term] id: FYPO:0003141 name: decreased protein tyrosine phosphorylation during cellular response to hydrogen peroxide def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of tyrosine residues in one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal during a cellular response to hydrogen peroxide." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased peptidyl-tyrosine phosphorylation during cellular response to hydrogen peroxide" EXACT [GO:0018108, PomBase:mah] synonym: "decreased protein tyrosine phosphorylation during cellular response to H2O2" EXACT [PomBase:mah] synonym: "decreased protein tyrosine phosphorylation during cellular response to hydrogen peroxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein tyrosine phosphorylation during cellular response to hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] synonym: "decreased tyrosine phosphorylation during cellular response to hydrogen peroxide" EXACT [PomBase:al] synonym: "reduced protein tyrosine phosphorylation during cellular response to hydrogen peroxide" EXACT [PomBase:mah] is_a: FYPO:0002375 ! decreased protein tyrosine phosphorylation is_a: FYPO:0002446 ! decreased protein phosphorylation during cellular response to hydrogen peroxide intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0070301 ! cellular response to hydrogen peroxide intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0018108 ! peptidyl-tyrosine phosphorylation relationship: happens_during GO:0070301 ! cellular response to hydrogen peroxide relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0018108 ! peptidyl-tyrosine phosphorylation created_by: midori creation_date: 2014-02-26T11:24:17Z [Term] id: FYPO:0003142 name: decreased RNA level during cellular response to methyl methanesulfonate def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to methyl methanesulfonate is lower than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased mRNA level during cellular response to methyl methanesulfonate" NARROW [PomBase:mah] synonym: "decreased RNA accumulation during cellular response to methyl methanesulfonate" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to methyl methanesulfonate during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to methyl methanesulfonate during vegetative growth" EXACT [PomBase:mah] synonym: "decreased RNA level during cellular response to methyl methanesulphonate" EXACT [PomBase:mah] synonym: "decreased RNA level during cellular response to MMS" EXACT [PomBase:mah] synonym: "decreased transcript level during cellular response to methyl methanesulfonate" EXACT [PomBase:vw] synonym: "reduced RNA level during cellular response to methyl methanesulfonate" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: exists_during GO:0072703 ! cellular response to methyl methanesulfonate intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: exists_during GO:0072703 ! cellular response to methyl methanesulfonate relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-02-26T11:41:17Z [Term] id: FYPO:0003143 name: decreased protein level during cellular response to methyl methanesulfonate def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during a cellular response to methyl methanesulfonate is lower than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein accumulation during cellular response to methyl methanesulfonate" RELATED [PomBase:mah] synonym: "decreased protein level during cellular response to methyl methanesulfonate during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein level during cellular response to methyl methanesulfonate during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein level during cellular response to methyl methanesulphonate" EXACT [PomBase:mah] synonym: "decreased protein level during cellular response to MMS" EXACT [PomBase:mah] synonym: "reduced protein level during cellular response to methyl methanesulfonate" EXACT [PomBase:mah] is_a: FYPO:0001324 ! decreased protein level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: exists_during GO:0072703 ! cellular response to methyl methanesulfonate intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: exists_during GO:0072703 ! cellular response to methyl methanesulfonate relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2014-02-26T11:43:44Z [Term] id: FYPO:0003144 name: normal protein level during cellular response to methyl methanesulfonate def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during a cellular response to the level of methyl methanesulfonate is normal (i.e. indistinguishable from wild type). Total protein or a specific protein may be affected." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein accumulation during cellular response to methyl methanesulfonate" RELATED [PomBase:mah] synonym: "normal protein level during cellular response to methyl methanesulfonate during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein level during cellular response to methyl methanesulfonate during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein level during cellular response to methyl methanesulphonate" EXACT [PomBase:mah] synonym: "normal protein level during cellular response to MMS" EXACT [PomBase:mah] is_a: FYPO:0000833 ! normal protein level during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: exists_during GO:0072703 ! cellular response to methyl methanesulfonate intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: exists_during GO:0072703 ! cellular response to methyl methanesulfonate relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2014-02-26T11:46:49Z [Term] id: FYPO:0003145 name: abnormal cell cycle arrest in mitotic prophase def: "A cellular process phenotype in which progression through the mitotic cell cycle is arrested in prophase under conditions where arrest does not normally occur." [PomBase:mah] synonym: "abnormal cell cycle arrest in mitotic prophase during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal mitotic cell cycle arrest in prophase" EXACT [GO:0000088] is_a: FYPO:0000608 ! abnormal cell cycle arrest in mitotic M phase intersection_of: during GO:0000088 ! mitotic prophase intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0071850 ! mitotic cell cycle arrest intersection_of: qualifier PATO:0000467 ! present relationship: during GO:0000088 ! mitotic prophase relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0071850 ! mitotic cell cycle arrest relationship: qualifier PATO:0000467 ! present created_by: midori creation_date: 2014-02-26T11:51:55Z [Term] id: FYPO:0003146 name: sensitive to hydrostatic pressure def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to hydrostatic pressure." [PomBase:mah] synonym: "hypersensitive to hydrostatic pressure" EXACT [PomBase:mah] synonym: "sensitive to hydrostatic pressure during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to hydrostatic pressure during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000304 ! sensitive to stress during vegetative growth created_by: midori creation_date: 2014-02-26T11:56:12Z [Term] id: FYPO:0003147 name: abnormal UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity def: "A molecular function phenotype in which the observed rate of UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0003975 ! UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0003975 ! UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-02-26T11:58:51Z [Term] id: FYPO:0003148 name: increased UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity def: "A molecular function phenotype in which the observed rate of UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity is increased." [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0003147 ! abnormal UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0003975 ! UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity relationship: inheres_in GO:0003975 ! UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity created_by: midori creation_date: 2014-02-26T11:59:00Z [Term] id: FYPO:0003149 name: decreased chromatin binding during cellular response to methyl methanesulfonate def: "A molecular function phenotype in which occurrence of chromatin binding by a gene product (usually a protein) in a mutant is decreased during a cellular response to methyl methanesulfonate. The affected gene product may be encoded by the mutated gene, or by a different gene, and may normally bind DNA, protein, or both in chromatin." [PomBase:mah] synonym: "decreased chromatin binding during cellular response to methyl methanesulphonate" EXACT [PomBase:mah] synonym: "decreased chromatin binding during cellular response to MMS" EXACT [PomBase:mah] synonym: "reduced chromatin binding during cellular response to methyl methanesulfonate" EXACT [PomBase:mah] is_a: FYPO:0002577 ! decreased chromatin binding intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072703 ! cellular response to methyl methanesulfonate intersection_of: inheres_in GO:0003682 ! chromatin binding relationship: happens_during GO:0072703 ! cellular response to methyl methanesulfonate relationship: inheres_in GO:0003682 ! chromatin binding created_by: midori creation_date: 2014-02-26T14:50:12Z [Term] id: FYPO:0003150 name: decreased activation of bipolar cell growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which activation of bipolar cell growth occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased activation of bipolar vegetative cell growth" EXACT [PomBase:mah] synonym: "decreased NETO" EXACT [PomBase:mah] synonym: "decreased new end take-off" EXACT [PomBase:mah] synonym: "reduced activation of bipolar cell growth" EXACT [PomBase:mah] is_a: FYPO:0000147 ! abnormal activation of bipolar cell growth is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051519 ! activation of bipolar cell growth relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051519 ! activation of bipolar cell growth created_by: midori creation_date: 2014-02-26T15:48:02Z [Term] id: FYPO:0003151 name: decreased protein level during cellular response to heat def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during a cellular response to heat is lower than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein accumulation during cellular response to heat" RELATED [PomBase:mah] synonym: "decreased protein level during cellular response to heat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein level during cellular response to heat during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein level during cellular response to heat" EXACT [PomBase:mah] is_a: FYPO:0001324 ! decreased protein level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0034605 ! cellular response to heat intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0034605 ! cellular response to heat relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2014-02-26T15:56:14Z [Term] id: FYPO:0003152 name: increased protein level during cellular response to heat def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during a cellular response to heat is higher than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein accumulation during cellular response to heat" RELATED [PomBase:mah] synonym: "increased protein level during cellular response to heat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein level during cellular response to heat during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001327 ! increased protein level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0034605 ! cellular response to heat intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0034605 ! cellular response to heat relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2014-02-26T15:57:07Z [Term] id: FYPO:0003153 name: normal protein level during cellular response to heat def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during a cellular response to heat is normal (i.e. indistinguishable from wild type). Total protein or a specific protein may be affected." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein accumulation during cellular response to heat" RELATED [PomBase:mah] synonym: "normal protein level during cellular response to heat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein level during cellular response to heat during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000833 ! normal protein level during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0034605 ! cellular response to heat intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0034605 ! cellular response to heat relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2014-02-26T15:58:08Z [Term] id: FYPO:0003154 name: abnormal vegetative cell growth def: "A cellular process phenotype in which cell growth is abnormal in the vegetative growth phase of the life cycle. Cell growth is the irreversible increase in size over time by accretion and biosynthetic production of matter similar to that already present." [PomBase:mah] comment: Note that this term refers to growth, i.e. increase in size, of an individual cell. If you have measured the rate or extent of growth of a culture in liquid medium or on plates, use one of the cell population growth terms, i.e. 'cell population growth phenotype' (FYPO:0000139) and its descendants. is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0002862 ! abnormal cell growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0016049 ! cell growth intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0016049 ! cell growth relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-02-26T16:03:54Z [Term] id: FYPO:0003155 name: intermittent monopolar cell growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which cells grow from one end, and do not grow continuously, but instead oscillate between periods of growth and pauses during which no growth occurs." [PMID:24146635, PomBase:mah] synonym: "intermittent monopolar vegetative cell growth" EXACT [PomBase:mah] is_a: FYPO:0003154 ! abnormal vegetative cell growth is_a: PATO:0000690 ! discontinuous intersection_of: PATO:0000690 ! discontinuous intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0042814 ! monopolar cell growth relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0042814 ! monopolar cell growth created_by: midori creation_date: 2014-02-26T16:08:07Z [Term] id: FYPO:0003156 name: normal monopolar cell growth def: "A cellular process phenotype in which the monopolar growth of a cell is normal (i.e. indistinguishable from wild type in timing, extent, rate, etc.) in the vegetative growth phase of the life cycle." [PMID:24146635, PomBase:mah] comment: Note that this term refers to growth at the level of any individual cell, and that it specifies only that increase in cell size due to metabolism is normal. Other aspects of the cell's biology may be abnormal, and other abnormalities may affect increase in cell number (population growth). Also see 'cell population growth phenotype' (FYPO:0000139) and its descendants. synonym: "normal monopolar vegetative cell growth" EXACT [PomBase:mah] is_a: FYPO:0002085 ! normal vegetative cell growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0042814 ! monopolar cell growth intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0042814 ! monopolar cell growth relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-02-26T16:13:48Z [Term] id: FYPO:0003157 name: unstable protein localization to growing cell tip def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a protein is localized to the growing cell tip, but does not remain there continuously." [PMID:24146635, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "unstable protein localisation to growing cell tip" EXACT [PomBase:mah] is_a: FYPO:0001584 ! abnormal protein localization to cell tip created_by: midori creation_date: 2014-02-26T16:34:09Z [Term] id: FYPO:0003158 name: abolished actin filament bundle assembly def: "A cytokinesis phenotype observed in the vegetative growth phase of the life cycle in which the assembly of actin filament bundles does not occur." [PomBase:mah] synonym: "abolished actin bundling" EXACT [PomBase:vw] synonym: "abolished actin filament bundle assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished actin filament bundle assembly during vegetative growth" EXACT [PomBase:mah] synonym: "actin bundling absent" EXACT [PomBase:vw] synonym: "actin filament bundle assembly abolished" EXACT [PomBase:mah] is_a: FYPO:0001010 ! abolished actin filament organization intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0051017 ! actin filament bundle assembly relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0051017 ! actin filament bundle assembly created_by: midori creation_date: 2014-02-26T17:05:36Z [Term] id: FYPO:0003159 name: cAMP absent from cell def: "A cell phenotype in which the amount of cyclic AMP (cAMP) measured in a cell is too low to detect." [PomBase:mah] synonym: "cyclic AMP absent from cell" EXACT [PomBase:mah] is_a: FYPO:0001208 ! substance absent from cell during vegetative growth is_a: FYPO:0001660 ! decreased cellular cAMP level intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:17489 ! 3',5'-cyclic AMP relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:17489 ! 3',5'-cyclic AMP created_by: midori creation_date: 2014-02-26T17:15:41Z [Term] id: FYPO:0003160 name: elongated cell during stationary phase def: "A cell morphology phenotype in which a cell is longer than normal, i.e. the maximum distance between the cell ends is greater than normal, when the cell is in a culture in stationary phase." [PomBase:mah] comment: Note that this term is classified as a type of abnormal cell shape, because wild-type cells are never seen with the proportions (length:width ratio) observed in elongated cells. Small cells, in contrast, have the same proportions as a subset of wild-type cells, and simply do not grow to the full length seen in wild type. synonym: "long cell during stationary phase" EXACT [PomBase:mah] is_a: FYPO:0000017 ! elongated cell created_by: midori creation_date: 2014-02-26T17:30:37Z [Term] id: FYPO:0003161 name: RNA absent from cell during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell is too low to detect. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "RNA absent from cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "transcripts absent from cell during vegetative growth" EXACT [PomBase:vw] synonym: "undetectable RNA level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth is_a: FYPO:0001208 ! substance absent from cell during vegetative growth is_a: FYPO:0001889 ! RNA absent from cell intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-02-26T17:36:19Z [Term] id: FYPO:0003162 name: RNA absent from cell during cellular response to salt stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell is too low to detect during a cellular response to salt stress. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "RNA absent from cell during cellular response to salt stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "RNA absent from cell during cellular response to salt stress during vegetative growth" EXACT [PomBase:mah] synonym: "transcripts absent from cell during cellular response to salt stress" EXACT [PomBase:vw] synonym: "undetectable RNA level during cellular response to salt stress" EXACT [PomBase:mah] is_a: FYPO:0002304 ! decreased RNA level during cellular response to salt stress is_a: FYPO:0003161 ! RNA absent from cell during vegetative growth intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0071472 ! cellular response to salt stress intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: during GO:0071472 ! cellular response to salt stress relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-02-26T17:37:56Z [Term] id: FYPO:0003163 name: abnormal nuclease activity def: "A molecular function phenotype in which the observed rate of nuclease activity is abnormal. All nuclease activities may be abnormal, or a specific nuclease activity may be assayed." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004518 ! nuclease activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004518 ! nuclease activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-02-26T17:42:24Z [Term] id: FYPO:0003164 name: abolished nuclease activity def: "A molecular function phenotype in which nuclease activity is absent. All nuclease activities may be absent, or a specific nuclease activity may be assayed." [PomBase:mah] synonym: "nuclease activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0003163 ! abnormal nuclease activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0004518 ! nuclease activity relationship: towards GO:0004518 ! nuclease activity created_by: midori creation_date: 2014-02-26T17:42:31Z [Term] id: FYPO:0003165 name: cut def: "An inviable phenotype observed in the vegetative growth phase of the life cycle in which a cell undergoes septation despite abnormal chromosome segregation, such that the septum physically divides the nucleus into two parts, and produces inviable daughter cells." [PomBase:jh, PomBase:mah, PomBase:vw] synonym: "cut during mitotic cell cycle" RELATED [PomBase:mah] synonym: "cut during vegetative growth" EXACT [PomBase:mah] synonym: "septation following abnormal chromosome segregation, with septum dividing nucleus" EXACT [PomBase:mah] is_a: FYPO:0000229 ! septation following abnormal mitotic chromosome segregation created_by: midori creation_date: 2014-03-05T10:47:49Z [Term] id: FYPO:0003166 name: septation following abnormal chromosome segregation, with anucleate cell formation def: "An inviable phenotype observed in the vegetative growth phase of the life cycle in which a cell undergoes septation despite abnormal chromosome segregation, producing inviable daughter cells, and in which the septum forms in a position that partitions both nuclei into one daughter cell." [PomBase:mah, PomBase:vw] comment: Consider also annotating to 'unequal mitotic sister chromatid segregation' (FYPO:0003241) or one of its descendants, because the abnormal chromosome segregation seen in these mutants often separates DNA into unequal portions. synonym: "abnormal nuclear segregation" RELATED [PomBase:al] synonym: "monoseptate vegetative cell with binucleate and anucleate compartments following abnormal chromosome segregation" EXACT [PomBase:mah] synonym: "nuclear missegregation" RELATED [PomBase:al] synonym: "septation following abnormal chromosome segregation, with binucleate cell formation" EXACT [PomBase:mah] is_a: FYPO:0000229 ! septation following abnormal mitotic chromosome segregation is_a: FYPO:0001489 ! inviable vegetative cell is_a: FYPO:0004699 ! monoseptate vegetative cell with binucleate and anucleate compartments created_by: midori creation_date: 2014-03-05T11:09:42Z [Term] id: FYPO:0003167 name: abnormal protein farnesyltransferase activity def: "A molecular function phenotype in which the observed rate of protein farnesyltransferase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004660 ! protein farnesyltransferase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004660 ! protein farnesyltransferase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-03-05T11:47:45Z [Term] id: FYPO:0003168 name: abolished protein farnesyltransferase activity def: "A molecular function phenotype in which protein farnesyltransferase activity is absent." [PomBase:mah] synonym: "protein farnesyltransferase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0003167 ! abnormal protein farnesyltransferase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0004660 ! protein farnesyltransferase activity relationship: towards GO:0004660 ! protein farnesyltransferase activity created_by: midori creation_date: 2014-03-05T11:47:54Z [Term] id: FYPO:0003169 name: increased amino acid import during vegetative growth def: "A cellular process phenotype in which the import of one or more amino acids into the cell occurs to a greater extent than normal in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "increased amino acid import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased amino acid import into cell during vegetative growth" EXACT [PomBase:al] synonym: "increased amino acid uptake during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001361 ! abnormal amino acid import during vegetative growth is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902837 ! amino acid import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902837 ! amino acid import into cell created_by: midori creation_date: 2014-03-05T11:52:32Z [Term] id: FYPO:0003170 name: increased arginine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of arginine into the cell occurs to a greater extent than normal." [PomBase:mah] synonym: "increased arginine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased arginine import during vegetative growth" EXACT [PomBase:mah] synonym: "increased arginine import into cell" EXACT [PomBase:al] synonym: "increased L-arginine import" EXACT [PomBase:mah] synonym: "increased L-arginine uptake" EXACT [PomBase:mah] is_a: FYPO:0001654 ! abnormal arginine import is_a: FYPO:0003169 ! increased amino acid import during vegetative growth intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902765 ! L-arginine import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902765 ! L-arginine import into cell created_by: midori creation_date: 2014-03-05T11:53:04Z [Term] id: FYPO:0003171 name: binucleate monoseptate cell with mitotic cell cycle arrest before cell separation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell has two nuclei and the mitotic cell cycle is arrested after the septum has formed, but before cells have separated." [PomBase:mah] synonym: "binucleate monoseptate cell with mitotic cell cycle arrest before cell separation after cytokinesis" EXACT [GO:0000920] synonym: "binucleate monoseptate cell with mitotic cell cycle arrest before cell separation after cytokinesis during vegetative growth" EXACT [PomBase:mah] synonym: "binucleate monoseptate cell with mitotic cell cycle arrest before cytokinetic cell separation" EXACT [GO:0000920] synonym: "mitotic cell cycle arrest before cell separation with binucleate monoseptate cell" EXACT [PomBase:vw] synonym: "nuclear division arrest with septation (normal cell length)" EXACT [PomBase:vw] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0001222 ! binucleate vegetative cell intersection_of: has_part FYPO:0001225 ! monoseptate intersection_of: has_part FYPO:0002888 ! mitotic cell cycle arrest before cell separation relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0001222 ! binucleate vegetative cell relationship: has_part FYPO:0001225 ! monoseptate relationship: has_part FYPO:0002888 ! mitotic cell cycle arrest before cell separation created_by: midori creation_date: 2014-03-05T14:33:43Z [Term] id: FYPO:0003172 name: abnormal cell cycle arrest in mitotic M phase without septation def: "A cellular process phenotype in which progression through the mitotic cell cycle is arrested in M phase under conditions where arrest does not normally occur, and the cell does not form a septum." [PomBase:mah] synonym: "abnormal cell cycle arrest in mitotic M phase without cytokinesis" RELATED [PomBase:mah] synonym: "abnormal cell cycle arrest in mitotic M phase without septation, normal cell size" EXACT [PomBase:mah] synonym: "abnormal mitotic cell cycle arrest in M phase without septation" EXACT [PomBase:mah] synonym: "abnormal nuclear division arrest without septation (normal cell length)" EXACT [PomBase:vw] is_a: FYPO:0000608 ! abnormal cell cycle arrest in mitotic M phase created_by: midori creation_date: 2014-03-05T15:03:46Z [Term] id: FYPO:0003173 name: abnormal nucleotide-excision repair def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which nucleotide-excision repair is abnormal. Nucleotide-excision repair is a DNA repair process in which a small region of the strand surrounding the damage is removed as an oligonucleotide,and the resulting small gap is filled in by the sequential action of DNA polymerase and DNA ligase." [GO:0006289, PomBase:mah] synonym: "abnormal excision repair" BROAD [PomBase:mah] synonym: "abnormal NER" EXACT [GO:0006289] synonym: "abnormal nucleotide-excision repair during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal nucleotide-excision repair during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000188 ! abnormal DNA repair intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006289 ! nucleotide-excision repair intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006289 ! nucleotide-excision repair relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-03-05T15:22:23Z [Term] id: FYPO:0003174 name: normal nucleotide-excision repair during cellular response to UV def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which nucleotide-excision repair is normal (i.e. indistinguishable from wild type) during a cellular response to ultraviolet light. Nucleotide-excision repair is a DNA repair process in which a small region of the strand surrounding the damage is removed as an oligonucleotide,and the resulting small gap is filled in by the sequential action of DNA polymerase and DNA ligase." [GO:0006289, PomBase:mah] synonym: "normal excision repair during cellular response to UV" BROAD [PomBase:mah] synonym: "normal NER during cellular response to UV" EXACT [GO:0006289] synonym: "normal nucleotide-excision repair during cellular response to ultraviolet light" EXACT [PomBase:mah] synonym: "normal nucleotide-excision repair during cellular response to UV during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal nucleotide-excision repair during cellular response to UV during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000859 ! normal metabolic process during vegetative growth is_a: FYPO:0000968 ! normal cellular response to stress intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0034644 ! cellular response to UV intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006289 ! nucleotide-excision repair intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0034644 ! cellular response to UV relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006289 ! nucleotide-excision repair relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-03-05T15:34:33Z [Term] id: FYPO:0003175 name: decreased nucleotide-excision repair during cellular response to UV def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which nucleotide-excision repair is decreased during a cellular response to ultraviolet light. Nucleotide-excision repair is a DNA repair process in which a small region of the strand surrounding the damage is removed as an oligonucleotide,and the resulting small gap is filled in by the sequential action of DNA polymerase and DNA ligase." [GO:0006289, PomBase:mah] synonym: "decreased excision repair during cellular response to UV" BROAD [PomBase:mah] synonym: "decreased NER during cellular response to UV" EXACT [GO:0006289] synonym: "decreased nucleotide-excision repair during cellular response to UV during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased nucleotide-excision repair during cellular response to UV during vegetative growth" EXACT [PomBase:mah] synonym: "reduced nucleotide-excision repair during cellular response to UV" EXACT [PomBase:mah] is_a: FYPO:0003173 ! abnormal nucleotide-excision repair is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0034644 ! cellular response to UV intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006289 ! nucleotide-excision repair relationship: happens_during GO:0034644 ! cellular response to UV relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006289 ! nucleotide-excision repair created_by: midori creation_date: 2014-03-05T15:40:08Z [Term] id: FYPO:0003176 name: normal meiotic chromosome segregation def: "A cellular process phenotype in which meiotic chromosome segregation is normal (i.e. indistinguishable from wild type). Meiotic chromosome segregation is the entire process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle." [GO:0045132, PomBase:mah] is_a: FYPO:0000627 ! normal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0045132 ! meiotic chromosome segregation intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0045132 ! meiotic chromosome segregation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-03-05T15:46:02Z [Term] id: FYPO:0003177 name: abnormal meiotic homologous chromosome biorientation def: "A cellular process phenotype in which homologous chromosome biorientation is abnormal during meiosis. Homologous chromosome biorientation is the process in which the sister centromeres of one chromosome attach to microtubules that emanate from the same spindle pole, ensuring that homologous maternal and paternal chromosomes are pulled in opposite directions at anaphase of meiosis I." [PomBase:mah] synonym: "abnormal homologous chromosome biorientation during meiosis" EXACT [PomBase:mah] synonym: "abnormal homologous chromosome orientation involved in meiotic metaphase I plate congression" EXACT [GO:0031619] is_a: FYPO:0000054 ! abnormal microtubule cytoskeleton organization is_a: FYPO:0002739 ! abnormal meiotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0031619 ! homologous chromosome orientation involved in meiotic metaphase I plate congression intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0031619 ! homologous chromosome orientation involved in meiotic metaphase I plate congression relationship: part_of FYPO:0004159 ! abnormal homologous chromosome segregation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-03-05T16:19:48Z [Term] id: FYPO:0003178 name: normal meiotic sister chromatid segregation def: "A cellular process phenotype in which the organization and subsequent separation of sister chromatids during the second meiotic division is normal (i.e. indistinguishable from wild type) during meiosis." [GO:0045144, PomBase:mah] synonym: "normal chromosome disjunction at meiosis II" EXACT [PomBase:al] synonym: "normal sister chromatid segregation during meiosis" EXACT [PomBase:mah] is_a: FYPO:0003176 ! normal meiotic chromosome segregation intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0045144 ! meiotic sister chromatid segregation intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0045144 ! meiotic sister chromatid segregation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-03-05T16:29:02Z [Term] id: FYPO:0003179 name: decreased intragenic meiotic recombination def: "A cellular process phenotype in which the occurrence of intragenic meiotic recombination is decreased. Intragenic meiotic recombination can result in gene conversion events." [PMID:16169489, PomBase:mah] synonym: "decreased meiotic intragenic recombination" EXACT [PMID:16169489, PomBase:al] synonym: "reduced intragenic meiotic recombination" EXACT [PomBase:mah] is_a: FYPO:0000485 ! decreased meiotic recombination created_by: midori creation_date: 2014-03-05T16:35:44Z [Term] id: FYPO:0003180 name: decreased intergenic meiotic recombination def: "A cellular process phenotype in which the occurrence of intergenic meiotic recombination is decreased. Intergenic meiotic recombination reflects crossovers between homologous chromosomes." [PMID:16169489, PomBase:mah] synonym: "decreased meiotic intergenic recombination" EXACT [PMID:16169489, PomBase:al] synonym: "reduced intergenic meiotic recombination" EXACT [PomBase:mah] is_a: FYPO:0000485 ! decreased meiotic recombination created_by: midori creation_date: 2014-03-05T16:46:00Z [Term] id: FYPO:0003181 name: abolished meiotic DNA double-strand break formation def: "A cellular process phenotype in which generation of double-strand breaks at defined hotspots throughout the genome during meiosis I does not occur." [GO:0042138, PomBase:mah] synonym: "absent meiotic DNA double-strand break formation" EXACT [PomBase:mah] synonym: "meiotic DNA double-strand break formation abolished" EXACT [PomBase:mah] is_a: FYPO:0003564 ! abnormal meiotic DNA double-strand break formation is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0042138 ! meiotic DNA double-strand break formation relationship: towards GO:0042138 ! meiotic DNA double-strand break formation created_by: midori creation_date: 2014-03-05T16:50:04Z [Term] id: FYPO:0003182 name: unequal meiotic sister chromatid segregation alt_id: FYPO:0003605 def: "A cellular process phenotype in which sister chromatids are not segregated equally to both spindle poles in the second meiotic nuclear division." [PMID:10440376, PomBase:mah] synonym: "chromosome nondisjunction at meiosis II" EXACT [PomBase:mah] synonym: "chromosome nondisjunction during meiosis II" EXACT [PomBase:mah] synonym: "unequal meiotic chromosome segregation during meiosis II" EXACT [PomBase:mah] is_a: FYPO:0000925 ! unequal meiotic chromosome segregation is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0045144 ! meiotic sister chromatid segregation relationship: towards GO:0045144 ! meiotic sister chromatid segregation created_by: midori creation_date: 2014-03-05T16:53:23Z [Term] id: FYPO:0003183 name: normal growth on phleomycin def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing phleomycin." [PomBase:mah] synonym: "normal cell population growth in presence of phleomycin" EXACT [PomBase:mah] synonym: "normal cell population growth on phleomycin" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to phleomycin" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on phleomycin" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0000047 ! normal cell population growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:75044 ! phleomycin relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:75044 ! phleomycin created_by: midori creation_date: 2014-03-05T16:57:31Z [Term] id: FYPO:0003184 name: normal protein localization to cytoskeleton during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the cytoskeleton is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to cytoskeleton during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein localization to cytoskeleton during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000644 ! normal protein localization during vegetative growth is_a: FYPO:0004096 ! normal protein localization to cytoskeleton intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0044380 ! protein localization to cytoskeleton intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0044380 ! protein localization to cytoskeleton relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-03-13T11:35:22Z [Term] id: FYPO:0003185 name: normal protein localization to microtubule cytoskeleton during mitotic interphase def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the microtubule cytoskeleton is normal (i.e. indistinguishable from wild type) during interphase of the mitotic cell cycle." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to microtubule cytoskeleton during mitotic interphase" EXACT [PomBase:mah] synonym: "normal protein localization to microtubule cytoskeleton during interphase during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003184 ! normal protein localization to cytoskeleton during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0051329 ! mitotic interphase intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0035372 ! protein localization to microtubule intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0051329 ! mitotic interphase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0035372 ! protein localization to microtubule relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-03-13T11:37:33Z [Term] id: FYPO:0003186 name: abolished protein localization to mitotic spindle def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the mitotic spindle does not occur." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "protein absent from mitotic spindle" RELATED [PomBase:mah] synonym: "protein localisation to mitotic spindle abolished" EXACT [PomBase:mah] synonym: "protein localization to mitotic spindle abolished" EXACT [PomBase:mah] synonym: "protein localization to spindle abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000934 ! abolished protein localization to microtubule cytoskeleton during vegetative growth is_a: FYPO:0002824 ! abnormal protein localization to mitotic spindle intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1902480 ! protein localization to mitotic spindle relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1902480 ! protein localization to mitotic spindle created_by: midori creation_date: 2014-03-13T11:40:00Z [Term] id: FYPO:0003187 name: protein mislocalized to astral microtubule during mitosis def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a protein that is not normally found associated with astral microtubules during mitosis is observed there during mitosis. The protein may or may not normally associate with astral microtubules during other cell cycle phases." [PomBase:mah] comment: Note that this term can be used to annotate any case where a protein is found at astral microtubules during mitosis in a mutant, but not in wild type. In some cases, there may be enough additional information to annotate to 'abnormal protein localization' (FYPO:0000443) or one of its descendants. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "ectopic protein localization to astral microtubule during mitosis" EXACT [PomBase:vw] synonym: "protein mislocalised to astral microtubule during mitosis" EXACT [PomBase:mah] synonym: "protein mislocalized to astral microtubule during mitosis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein mislocalized to astral microtubule during mitosis during vegetative growth" EXACT [PomBase:mah] synonym: "protein mislocalized to astral microtubule during mitotic M phase" EXACT [PomBase:mah] synonym: "protein mislocalized to astral microtubule during mitotic nuclear division" EXACT [GO:0007067] is_a: FYPO:0000782 ! mislocalized protein during vegetative growth intersection_of: PATO:0000628 ! mislocalised intersection_of: exists_during GO:0007067 ! mitotic nuclear division intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CHEBI:36080 ! protein intersection_of: towards GO:0000235 ! astral microtubule relationship: exists_during GO:0007067 ! mitotic nuclear division relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CHEBI:36080 ! protein relationship: towards GO:0000235 ! astral microtubule created_by: midori creation_date: 2014-03-13T11:49:41Z [Term] id: FYPO:0003188 name: abnormal protein import into nucleus def: "A transport phenotype observed in the vegetative growth phase of the life cycle in which the import of protein into the nucleus is abnormal. Import of all proteins or a specific protein may be affected." [PomBase:mah] comment: Encompasses both export of proteins normally retained in the nucleus and nuclear retention of normally exported proteins. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein import into nucleus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein import into nucleus during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000215 ! abnormal intracellular protein transport is_a: FYPO:0000506 ! abnormal nuclear export is_a: FYPO:0001129 ! abnormal protein localization to nucleus during vegetative growth is_a: FYPO:0001217 ! abnormal nuclear import intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006606 ! protein import into nucleus intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006606 ! protein import into nucleus relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-03-13T11:53:16Z [Term] id: FYPO:0003189 name: decreased protein import into nucleus def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of protein import into the nucleus is decreased. Import of all proteins or a specific protein may be affected." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein import into nucleus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein import into nucleus during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein import into nucleus" EXACT [PomBase:mah] is_a: FYPO:0000515 ! decreased nuclear import is_a: FYPO:0000541 ! decreased protein transport is_a: FYPO:0001514 ! decreased protein localization to nucleus during vegetative growth is_a: FYPO:0003188 ! abnormal protein import into nucleus intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006606 ! protein import into nucleus relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006606 ! protein import into nucleus created_by: midori creation_date: 2014-03-13T11:53:49Z [Term] id: FYPO:0003190 name: decreased rate of cytoplasmic microtubule depolymerization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which cytoplasmic microtubule depolymerization, i.e. the removal of tubulin dimers from a cytoplasmic microtubule, occurs at a lower rate, or speed, than normal." [GO:0007019, PomBase:mah] synonym: "decreased cytoplasmic microtubule depolymerization rate" EXACT [PomBase:mah] synonym: "decreased rate of cytoplasmic microtubule depolymerization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased rate of cytoplasmic microtubule depolymerization during vegetative growth" EXACT [PomBase:mah] synonym: "decreased rate of cytoplasmic microtubule shrinkage" RELATED [PomBase:vw] synonym: "increased cytoplasmic microtubule stability" RELATED [PomBase:vw] synonym: "reduced rate of microtubule depolymerization" EXACT [PomBase:mah] is_a: FYPO:0000903 ! decreased rate of microtubule depolymerization intersection_of: PATO:0000911 ! decreased rate intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0010938 ! cytoplasmic microtubule depolymerization relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0010938 ! cytoplasmic microtubule depolymerization created_by: midori creation_date: 2014-03-13T15:13:29Z [Term] id: FYPO:0003191 name: abolished protein localization to microtubule during mitotic interphase, with protein mislocalized to cytoplasmic foci def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to microtubules does not occur, and the protein is instead visible in one or a few foci or dots in the cytoplasm, during interphase of the mitotic cell cycle." [PMID:18799626, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to microtubule during mitotic interphase, with protein mislocalised to cytoplasmic foci" EXACT [PomBase:mah] synonym: "protein localization to microtubule abolished during interphase during vegetative growth, with protein mislocalized to cytoplasmic foci" EXACT [PomBase:mah] synonym: "protein localization to microtubule abolished during mitotic interphase, with protein mislocalized to cytoplasmic foci" EXACT [PomBase:mah] is_a: FYPO:0000931 ! abnormal protein localization to microtubule cytoskeleton during vegetative growth created_by: midori creation_date: 2014-03-13T15:45:40Z [Term] id: FYPO:0003192 name: abolished protein localization to nucleus during mitosis def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleus is abolished during mitosis." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to nucleus during mitosis" EXACT [PomBase:mah] synonym: "abolished protein localization to nucleus during mitosis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to nucleus during mitosis during vegetative growth" EXACT [PomBase:mah] synonym: "abolished protein localization to nucleus during mitotic M phase" RELATED [PomBase:mah] synonym: "abolished protein localization to nucleus during mitotic M-phase" RELATED [PomBase:vw] synonym: "abolished protein localization to nucleus during mitotic nuclear division" EXACT [GO:0007067] synonym: "protein localization to nucleus abolished during mitosis" EXACT [PomBase:mah] is_a: FYPO:0001424 ! abolished protein localization to nucleus during vegetative growth intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0007067 ! mitotic nuclear division intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0034504 ! protein localization to nucleus relationship: during GO:0007067 ! mitotic nuclear division relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0034504 ! protein localization to nucleus created_by: midori creation_date: 2014-03-13T16:03:31Z [Term] id: FYPO:0003193 name: normal rate of microtubule depolymerization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the rate, or speed, of microtubule depolymerization, i.e. the removal of tubulin dimers from a microtubule, is normal (i.e. indistinguishable from wild type)." [PMID:23051734, PomBase:mah] synonym: "normal microtubule depolymerization rate" EXACT [PomBase:mah] synonym: "normal rate of microtubule depolymerization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal rate of microtubule depolymerization during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000899 ! normal microtubule cytoskeleton organization is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate intersection_of: inheres_in GO:0007019 ! microtubule depolymerization intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0007019 ! microtubule depolymerization relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-03-13T16:05:44Z [Term] id: FYPO:0003194 name: increased rate of microtubule depolymerization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which microtubule depolymerization, i.e. the removal of tubulin dimers from a microtubule, occurs at a greater rate, or speed, than normal." [GO:0007019, PomBase:mah] synonym: "decreased microtubule stability" RELATED [PomBase:vw] synonym: "increased microtubule depolymerization rate" EXACT [PomBase:mah] synonym: "increased rate of microtubule depolymerization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased rate of microtubule depolymerization during vegetative growth" EXACT [PomBase:mah] synonym: "increased rate of microtubule shrinkage" RELATED [PomBase:vw] is_a: FYPO:0000902 ! abnormal microtubule depolymerization is_a: PATO:0000912 ! increased rate intersection_of: PATO:0000912 ! increased rate intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0007019 ! microtubule depolymerization relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0007019 ! microtubule depolymerization created_by: midori creation_date: 2014-03-13T16:08:23Z [Term] id: FYPO:0003195 name: altered RNA level during cellular response to phosphate starvation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell differs from normal during a cellular response to phosphate starvation. Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "abnormal RNA level during cellular response to phosphate starvation" EXACT [PomBase:mah] synonym: "altered cellular RNA level during cellular response to phosphate starvation" EXACT [PomBase:mah] synonym: "altered RNA level during cellular response to phosphate starvation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "altered RNA level during cellular response to phosphate starvation during vegetative growth" EXACT [PomBase:mah] synonym: "altered RNA level during phosphate starvation" EXACT [PomBase:mah] synonym: "altered transcript level during cellular response to phosphate starvation" EXACT [PomBase:vw] is_a: FYPO:0001326 ! altered RNA level during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0016036 ! cellular response to phosphate starvation intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0016036 ! cellular response to phosphate starvation relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-03-13T16:42:48Z [Term] id: FYPO:0003196 name: altered RNA level during cellular response to iron ion starvation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell differs from normal during a cellular response to iron ion starvation. Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "abnormal RNA level during cellular response to iron ion starvation" EXACT [PomBase:mah] synonym: "altered cellular RNA level during cellular response to iron ion starvation" EXACT [PomBase:mah] synonym: "altered RNA level during cellular response to iron ion starvation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "altered RNA level during cellular response to iron ion starvation during vegetative growth" EXACT [PomBase:mah] synonym: "altered RNA level during cellular response to iron starvation" EXACT [PomBase:mah] synonym: "altered RNA level during iron starvation" EXACT [PomBase:mah] synonym: "altered transcript level during cellular response to iron ion starvation" EXACT [PomBase:vw] is_a: FYPO:0001326 ! altered RNA level during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0010106 ! cellular response to iron ion starvation intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0010106 ! cellular response to iron ion starvation relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-03-13T16:52:11Z [Term] id: FYPO:0003197 name: altered RNA level during cellular response to copper ion starvation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell differs from normal during a cellular response to copper ion starvation. Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "abnormal RNA level during cellular response to copper ion starvation" EXACT [PomBase:mah] synonym: "altered cellular RNA level during cellular response to copper ion starvation" EXACT [PomBase:mah] synonym: "altered RNA level during cellular response to copper ion starvation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "altered RNA level during cellular response to copper ion starvation during vegetative growth" EXACT [PomBase:mah] synonym: "altered RNA level during cellular response to copper starvation" EXACT [PomBase:mah] synonym: "altered RNA level during copper starvation" EXACT [PomBase:mah] synonym: "altered transcript level during cellular response to copper ion starvation" EXACT [PomBase:vw] is_a: FYPO:0001326 ! altered RNA level during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0035874 ! cellular response to copper ion starvation intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0035874 ! cellular response to copper ion starvation relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-03-13T16:54:50Z [Term] id: FYPO:0003198 name: altered RNA level during cellular response to osmotic stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell differs from normal during a cellular response to osmotic stress. Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "abnormal RNA level during cellular response to osmotic stress" EXACT [PomBase:mah] synonym: "altered cellular RNA level during cellular response to osmotic stress" EXACT [PomBase:mah] synonym: "altered RNA level during cellular response to osmotic stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "altered RNA level during cellular response to osmotic stress during vegetative growth" EXACT [PomBase:mah] synonym: "altered RNA level during osmotic stress" EXACT [PomBase:mah] synonym: "altered transcript level during cellular response to osmotic stress" EXACT [PomBase:vw] is_a: FYPO:0001326 ! altered RNA level during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0071470 ! cellular response to osmotic stress intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0071470 ! cellular response to osmotic stress relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-03-13T16:55:44Z [Term] id: FYPO:0003199 name: altered RNA level during cellular response to glucose starvation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell differs from normal during a cellular response to glucose starvation. Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "abnormal RNA level during cellular response to glucose starvation" EXACT [PomBase:mah] synonym: "altered cellular RNA level during cellular response to glucose starvation" EXACT [PomBase:mah] synonym: "altered RNA level during cellular response to glucose starvation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "altered RNA level during cellular response to glucose starvation during vegetative growth" EXACT [PomBase:mah] synonym: "altered RNA level during glucose starvation" EXACT [PomBase:mah] synonym: "altered transcript level during cellular response to glucose starvation" EXACT [PomBase:vw] is_a: FYPO:0001326 ! altered RNA level during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0042149 ! cellular response to glucose starvation intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0042149 ! cellular response to glucose starvation relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-03-13T16:56:41Z [Term] id: FYPO:0003200 name: normal transcription regulatory region sequence-specific DNA binding during cellular response to phosphate starvation def: "A molecular function phenotype in which occurrence of DNA binding at a replication origin by a gene product is normal (i.e. indistinguishable from wild type). The relevant gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "normal DNA binding at transcription regulatory region sequence-specific during cellular response to phosphate starvation" EXACT [PomBase:mah] synonym: "normal promoter binding during cellular response to phosphate starvation" RELATED [PomBase:mah] synonym: "normal transcription regulatory region binding during cellular response to phosphate starvation" EXACT [PomBase:mah] synonym: "normal transcription regulatory region binding during phosphate starvation" EXACT [PomBase:mah] is_a: FYPO:0000655 ! normal DNA binding intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0016036 ! cellular response to phosphate starvation intersection_of: inheres_in GO:0000976 ! transcription regulatory region sequence-specific DNA binding intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0016036 ! cellular response to phosphate starvation relationship: inheres_in GO:0000976 ! transcription regulatory region sequence-specific DNA binding relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-03-13T16:59:44Z [Term] id: FYPO:0003201 name: decreased rate of primary cell septum biogenesis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the rate, or speed, of primary cell septum biogenesis is decreased." [PomBase:al, PomBase:mah] synonym: "decreased rate of primary cell septum biogenesis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased rate of primary cell septum biogenesis during vegetative growth" EXACT [PomBase:mah] synonym: "decreased rate of primary septum biogenesis" EXACT [PomBase:mah] synonym: "increased duration of primary cell septum biogenesis" RELATED [PomBase:mah] synonym: "reduced rate of primary cell septum biogenesis" EXACT [PomBase:mah] is_a: FYPO:0000117 ! abnormal septation is_a: PATO:0000911 ! decreased rate intersection_of: PATO:0000911 ! decreased rate intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0031671 ! primary cell septum biogenesis relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0031671 ! primary cell septum biogenesis created_by: midori creation_date: 2014-03-13T17:09:40Z [Term] id: FYPO:0003202 name: actomyosin contractile ring contraction uncoupled from septum assembly def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which actomyosin contractile ring contraction is not spatially and temporally coupled to barrier septum assembly as in wild type. The edges of the growing septum and the plasma membrane do not remain in contact, and septum assembly may be slower than ring contraction." [PMID:24165938, PomBase:mah] synonym: "actomyosin contractile ring contraction uncoupled from septum assembly" EXACT [PomBase:vw] synonym: "actomyosin contractile ring contraction uncoupled from septum assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "actomyosin contractile ring contraction uncoupled from septum assembly during vegetative growth" EXACT [PomBase:mah] synonym: "cytokinetic contractile ring contraction uncoupled from septum assembly" EXACT [PomBase:vw] is_a: FYPO:0000117 ! abnormal septation is_a: FYPO:0001364 ! abnormal actomyosin contractile ring contraction created_by: midori creation_date: 2014-03-13T17:13:00Z [Term] id: FYPO:0003203 name: curved septum def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell forms a septum that is curved." [PomBase:mah] synonym: "curved septum during mitotic cell cycle" RELATED [PomBase:mah] synonym: "curved septum during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002023 ! abnormal septum morphology during vegetative growth is_a: PATO:0000406 ! curved intersection_of: PATO:0000406 ! curved intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000935 ! barrier septum relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000935 ! barrier septum created_by: midori creation_date: 2014-03-13T17:15:03Z [Term] id: FYPO:0003204 name: secondary cell septum absent from cell during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the cell does not contain a detectable secondary cell septum." [PomBase:mah] synonym: "absent secondary cell septum during vegetative growth" EXACT [PomBase:mah] synonym: "secondary cell septum absent from cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "secondary septum absent from cell during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002455 ! abnormal septum during vegetative growth is_a: PATO:0002000 ! lacks all parts of type intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards GO:0051077 ! secondary cell septum relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards GO:0051077 ! secondary cell septum created_by: midori creation_date: 2014-03-13T17:19:11Z [Term] id: FYPO:0003205 name: decreased primary cell septum thickness def: "A septation phenotype observed in the vegetative growth phase of the life cycle in which a cell forms a primary septum that is thinner than normal." [PomBase:mah] synonym: "decreased primary cell septum thickness during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased primary cell septum thickness during vegetative growth" EXACT [PomBase:mah] synonym: "decreased primary septum thickness" EXACT [PomBase:mah] synonym: "reduced primary cell septum thickness" EXACT [PomBase:mah] synonym: "thin primary septum" EXACT [PomBase:mah] is_a: FYPO:0002023 ! abnormal septum morphology during vegetative growth is_a: PATO:0000592 ! decreased thickness intersection_of: PATO:0000592 ! decreased thickness intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000936 ! primary cell septum relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000936 ! primary cell septum created_by: midori creation_date: 2014-03-13T17:26:49Z [Term] id: FYPO:0003206 name: decreased protein binding during cellular response to salt stress def: "A molecular function phenotype in which the binding of one protein to another occurs to a lower extent than normal during a cellular response to salt stress. The relevant proteins may include the one encoded by the mutated gene, or may both be encoded by different genes." [PomBase:mah] comment: This term can be used for any protein-protein interaction that is affected by a mutation, whether or not the mutated gene product is one of the interacting proteins. We recommend noting which proteins were used in the assay when annotating to this term. synonym: "decreased protein binding during salt stress" EXACT [PomBase:mah] synonym: "decreased protein binding in response to salt stress" RELATED [PomBase:al] synonym: "decreased protein-protein interaction during cellular response to salt stress" EXACT [PomBase:mah] synonym: "reduced protein binding during cellular response to salt stress" EXACT [PomBase:mah] is_a: FYPO:0001645 ! decreased protein binding intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0071472 ! cellular response to salt stress intersection_of: inheres_in GO:0005515 ! protein binding relationship: happens_during GO:0071472 ! cellular response to salt stress relationship: inheres_in GO:0005515 ! protein binding created_by: midori creation_date: 2014-03-13T17:29:53Z [Term] id: FYPO:0003207 name: decreased protein binding during cellular response to hydrogen peroxide def: "A molecular function phenotype in which the binding of one protein to another occurs to a lower extent than normal during a cellular response to hydrogen peroxide. The relevant proteins may include the one encoded by the mutated gene, or may both be encoded by different genes." [PomBase:mah] comment: This term can be used for any protein-protein interaction that is affected by a mutation, whether or not the mutated gene product is one of the interacting proteins. We recommend noting which proteins were used in the assay when annotating to this term. synonym: "decreased protein binding during cellular response to H2O2" EXACT [PomBase:mah] synonym: "decreased protein binding in response to hydrogen peroxide" RELATED [PomBase:al] synonym: "decreased protein-protein interaction during cellular response to hydrogen peroxide" EXACT [PomBase:mah] synonym: "reduced protein binding during cellular response to hydrogen peroxide" EXACT [PomBase:mah] is_a: FYPO:0001645 ! decreased protein binding intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0070301 ! cellular response to hydrogen peroxide intersection_of: inheres_in GO:0005515 ! protein binding relationship: happens_during GO:0070301 ! cellular response to hydrogen peroxide relationship: inheres_in GO:0005515 ! protein binding created_by: midori creation_date: 2014-03-13T17:31:46Z [Term] id: FYPO:0003208 name: decreased protein localization to cell tip, with protein distributed in plasma membrane or cortex def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the cell tip is decreased, and an increased amount of the protein is instead detected distributed throughout the plasma membrane and/or cell cortex." [PMID:22891259, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to cell tip, with protein distributed in plasma membrane or cortex" EXACT [GO:0034504, PomBase:mah] synonym: "decreased protein localization to cell tip, with protein distributed in plasma membrane or cortex during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to cell tip, with protein distributed in plasma membrane or cortex, during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to cell tip, with protein distributed in plasma membrane or cortex" EXACT [PomBase:mah] is_a: FYPO:0001586 ! decreased protein localization to cell tip created_by: midori creation_date: 2014-03-19T10:35:23Z [Term] id: FYPO:0003209 name: abolished protein localization to cell tip, with protein mislocalized to cytoplasm def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the cell tip is abolished, and the protein is present in the cytoplasm instead." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to cell tip, with protein mislocalised to cytoplasm" EXACT [PomBase:mah] synonym: "abolished protein localization to cell tip during vegetative growth, with protein mislocalized to cytoplasm" EXACT [PomBase:mah] synonym: "abolished protein localization to cell tip, with protein mislocalized to cytoplasm during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein localization to cell tip abolished, with protein mislocalized to cytoplasm" EXACT [PomBase:mah] is_a: FYPO:0001585 ! abolished protein localization to cell tip created_by: midori creation_date: 2014-03-19T10:46:02Z [Term] id: FYPO:0003210 name: mislocalized, misoriented septum def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which a cell has a septum that is in an abnormal location and is not perpendicular to the long axis of the cell. The normal location is at the midpoint of the long axis of the cell." [PomBase:mah] comment: Note that the location of the septum is determined by the location of the contractile ring, which in turn is determined by the location of the cell division site, so an abnormality in cell division site determination can be inferred from this phenotype. Consider also annotating to 'mislocalized actomyosin contractile ring' (FYPO:0001369) because if the contractile ring forms in an abnormal location, the septum will also do so. synonym: "abnormal septum localization and orientation" RELATED [PomBase:mah] synonym: "abnormal septum location and orientation" EXACT [PomBase:mah] synonym: "abnormal septum position and orientation" EXACT [PomBase:mah] synonym: "abnormal septum positioning and orientation" RELATED [PomBase:mah] synonym: "asymmetric, misoriented septum" EXACT [PomBase:mah] synonym: "asymmetrically located, misoriented septum" EXACT [PomBase:mah] synonym: "mislocalised, misoriented septum" EXACT [PomBase:mah] synonym: "mislocalized, misoriented septum during mitotic cell cycle" RELATED [PomBase:mah] synonym: "mislocalized, misoriented septum during vegetative growth" EXACT [PomBase:mah] synonym: "misplaced, misoriented septum" EXACT [PomBase:vw] is_a: FYPO:0002455 ! abnormal septum during vegetative growth intersection_of: FYPO:0002455 ! abnormal septum during vegetative growth intersection_of: has_part FYPO:0000339 ! mislocalized septum during vegetative growth intersection_of: has_part FYPO:0001390 ! misoriented septum during vegetative growth relationship: has_part FYPO:0000339 ! mislocalized septum during vegetative growth relationship: has_part FYPO:0001390 ! misoriented septum during vegetative growth created_by: midori creation_date: 2014-03-19T10:50:08Z [Term] id: FYPO:0003211 name: abnormal secondary cell septum biogenesis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which secondary cell septum biogenesis is abnormal. Secondary cell septum biogenesis results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of the secondary cell septum during cytokinesis." [PomBase:mah] comment: Consider also annotating to 'abnormal contractile ring localization' (FYPO:0000033) because if the contractile ring forms in an abnormal location, the septum will also do so. The positions of both the contractile ring and the septum are determined by the processes that select the site of cell division. synonym: "abnormal secondary cell septum biogenesis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal secondary cell septum biogenesis during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal secondary cell septum formation" RELATED [PomBase:mah] synonym: "abnormal secondary septum biogenesis" EXACT [PomBase:mah] is_a: FYPO:0000117 ! abnormal septation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1990344 ! secondary cell septum biogenesis intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1990344 ! secondary cell septum biogenesis relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-03-19T10:58:05Z [Term] id: FYPO:0003212 name: kinked septum def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell forms a septum that is kinked, i.e. has multiple angles along its length." [PMID:22891259, PomBase:mah] synonym: "kinked septum during mitotic cell cycle" RELATED [PomBase:mah] synonym: "kinked septum during vegetative growth" EXACT [PomBase:mah] synonym: "twisted septum" RELATED [PATO:0001798, PMID:22891259] is_a: FYPO:0002023 ! abnormal septum morphology during vegetative growth is_a: PATO:0001798 ! kinked intersection_of: PATO:0001798 ! kinked intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000935 ! barrier septum relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000935 ! barrier septum created_by: midori creation_date: 2014-03-19T11:10:26Z [Term] id: FYPO:0003213 name: explosive cytokinetic cell separation resulting in vegetative cell lysis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which cell separation is instantaneous and asymmetrical, with a ripped primary septum. Explosive cell separation takes a few seconds (rather than 5-6 minutes as in wild type) and involves asymmetrical degradation and/or breakage of the septum edging followed by an abrupt tear of a weak primary septum and an instantaneous curvature of the secondary septum." [PMID:22891259, PomBase:mah] synonym: "side-explosive cell separation" EXACT [PMID:22891259] is_a: FYPO:0000164 ! abnormal cell separation after cytokinesis relationship: has_output FYPO:0003440 ! cell lysis during cytokinesis created_by: midori creation_date: 2014-03-19T11:16:27Z [Term] id: FYPO:0003214 name: normal protein phosphorylation during cellular response to glucose starvation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins is normal (i.e. indistinguishable from wild type) during a cellular response to glucose starvation." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein phosphorylation during cellular response to glucose starvation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein phosphorylation during cellular response to glucose starvation during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein phosphorylation during glucose starvation" EXACT [PomBase:mah] is_a: FYPO:0000776 ! normal protein phosphorylation during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0042149 ! cellular response to glucose starvation intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0042149 ! cellular response to glucose starvation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-03-19T11:26:01Z [Term] id: FYPO:0003215 name: normal protein binding during cellular response to hydrogen peroxide def: "A molecular function phenotype in which the binding of one protein to another is normal (i.e. indistinguishable from wild type) during a cellular response to hydrogen peroxide. The relevant proteins may include the one encoded by the mutated gene, or may both be encoded by different genes." [PomBase:mah] comment: This term can be used for any protein-protein interaction that is tested in a mutant, whether or not the mutated gene product is one of the interacting proteins. We recommend noting which proteins were used in the assay when annotating to this term. synonym: "normal protein binding during cellular response to H2O2" EXACT [PomBase:mah] synonym: "normal protein-protein interaction during cellular response to hydrogen peroxide" EXACT [PomBase:mah] is_a: FYPO:0000703 ! normal protein binding intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0070301 ! cellular response to hydrogen peroxide intersection_of: inheres_in GO:0005515 ! protein binding intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0070301 ! cellular response to hydrogen peroxide relationship: inheres_in GO:0005515 ! protein binding relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-03-19T11:28:46Z [Term] id: FYPO:0003216 name: decreased chromatin silencing at rDNA def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of chromatin silencing at ribosomal DNA repeat regions is decreased." [PomBase:mah] synonym: "decreased chromatin silencing at rDNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased chromatin silencing at rDNA during vegetative growth" EXACT [PomBase:mah] synonym: "decreased chromatin silencing at ribosomal DNA" EXACT [PomBase:mah] synonym: "reduced chromatin silencing at rDNA" EXACT [PomBase:mah] is_a: FYPO:0002353 ! decreased chromatin silencing intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000183 ! chromatin silencing at rDNA relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000183 ! chromatin silencing at rDNA created_by: midori creation_date: 2014-03-19T11:38:08Z [Term] id: FYPO:0003217 name: decreased chromatin silencing at centromere central core def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of chromatin silencing at the central core of the centromeric regions is decreased." [PomBase:mah] synonym: "decreased chromatin silencing at centromere central core during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased chromatin silencing at centromere central core during vegetative growth" EXACT [PomBase:mah] synonym: "reduced chromatin silencing at centromere central core" EXACT [PomBase:mah] is_a: FYPO:0002834 ! decreased chromatin silencing at centromere intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072692 ! chromatin silencing at centromere central core relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072692 ! chromatin silencing at centromere central core created_by: midori creation_date: 2014-03-19T11:40:22Z [Term] id: FYPO:0003218 name: abolished tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the modification of a wobble base uridine residue in a tRNA to 5-methoxycarbonylmethyl-2-thiouridine is abolished." [GO:0002926, PomBase:mah] synonym: "abolished mcm5s2U34 biosynthesis" EXACT [GO:0002926, PomBase:mah] synonym: "abolished thiolation and methoxycarbonylmethylation at tRNA U34" EXACT [PomBase:al] synonym: "abolished tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "tRNA U34 5-methoxycarbonylmethyl-2-thiouridine biosynthesis" EXACT [GO:0002926, PomBase:mah] synonym: "tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis abolished" EXACT [PomBase:mah] synonym: "tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000371 ! abolished RNA modification is_a: FYPO:0001172 ! abnormal 7-methylguanosine cap hypermethylation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0002926 ! tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis. relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0002926 ! tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis. created_by: midori creation_date: 2014-03-19T11:54:10Z [Term] id: FYPO:0003219 name: decreased histone H3-K9K14 acetylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which acetylation of lysine at positions 9 and 14 of histone H3 occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased histone H3 K9K14 acetylation" EXACT [PomBase:mah] synonym: "decreased histone H3-K9 and K14 acetylation" EXACT [PomBase:mah] synonym: "decreased histone H3-K9K14 acetylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H3-K9K14 acetylation during vegetative growth" EXACT [PomBase:mah] synonym: "decreased histone lysine H3 K9K14 acetylation" EXACT [PomBase:mah] synonym: "reduced histone H3-K9K14 acetylation" EXACT [PomBase:mah] is_a: FYPO:0001442 ! decreased histone H3-K9 acetylation is_a: FYPO:0001458 ! decreased histone H3-K14 acetylation intersection_of: FYPO:0000114 ! cellular process phenotype intersection_of: has_part FYPO:0001442 ! decreased histone H3-K9 acetylation intersection_of: has_part FYPO:0001458 ! decreased histone H3-K14 acetylation relationship: has_part FYPO:0001442 ! decreased histone H3-K9 acetylation relationship: has_part FYPO:0001458 ! decreased histone H3-K14 acetylation created_by: midori creation_date: 2014-03-19T14:09:21Z [Term] id: FYPO:0003220 name: normal histone H3-K9K14 acetylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which acetylation of lysine at positions 9 and 14 of histone H3 is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal histone H3 K9K14 acetylation" EXACT [PomBase:mah] synonym: "normal histone H3-K9 and K14 acetylation" EXACT [PomBase:mah] synonym: "normal histone H3-K9K14 acetylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal histone H3-K9K14 acetylation during vegetative growth" EXACT [PomBase:mah] synonym: "normal histone lysine H3 K9K14 acetylation" EXACT [PomBase:mah] is_a: FYPO:0003221 ! normal histone acetylation intersection_of: FYPO:0000114 ! cellular process phenotype intersection_of: has_part FYPO:0003223 ! normal histone H3-K9 acetylation intersection_of: has_part FYPO:0003224 ! normal histone H3-K14 acetylation relationship: has_part FYPO:0003223 ! normal histone H3-K9 acetylation relationship: has_part FYPO:0003224 ! normal histone H3-K14 acetylation created_by: midori creation_date: 2014-03-19T14:13:02Z [Term] id: FYPO:0003221 name: normal histone acetylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone acetylation is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal histone acetylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal histone acetylation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002600 ! normal histone modification is_a: FYPO:0003362 ! normal protein acetylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0016573 ! histone acetylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0016573 ! histone acetylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-03-19T14:13:37Z [Term] id: FYPO:0003222 name: sensitive to zearalenone def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to zearalenone. Cells stop growing (and may die) at a concentration of zearalenone that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to zearalenone" EXACT [PomBase:mah] synonym: "sensitive to ZEA" EXACT [PomBase:al] synonym: "sensitive to zearalenone during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to zearalenone during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:10106 ! zearalenone relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:10106 ! zearalenone created_by: midori creation_date: 2014-03-19T14:19:37Z [Term] id: FYPO:0003223 name: normal histone H3-K9 acetylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which acetylation of lysine at position 9 of histone H3 is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal histone H3 K9 acetylation" EXACT [PomBase:mah] synonym: "normal histone H3-K9 acetylation" EXACT [PomBase:mah] synonym: "normal histone H3-K9 acetylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal histone H3-K9 acetylation during vegetative growth" EXACT [PomBase:mah] synonym: "normal histone lysine H3 K9 acetylation" EXACT [PomBase:mah] is_a: FYPO:0003221 ! normal histone acetylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0043970 ! histone H3-K9 acetylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0043970 ! histone H3-K9 acetylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-03-19T14:36:25Z [Term] id: FYPO:0003224 name: normal histone H3-K14 acetylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which acetylation of lysine at position 14 of histone H3 is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal histone H3 K14 acetylation" EXACT [PomBase:mah] synonym: "normal histone H3-K14 acetylation" EXACT [PomBase:mah] synonym: "normal histone H3-K14 acetylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal histone H3-K14 acetylation during vegetative growth" EXACT [PomBase:mah] synonym: "normal histone lysine H3 K14 acetylation" EXACT [PomBase:mah] is_a: FYPO:0003221 ! normal histone acetylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0044154 ! histone H3-K14 acetylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0044154 ! histone H3-K14 acetylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-03-19T14:39:12Z [Term] id: FYPO:0003225 name: normal rate of microtubule polymerization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the rate, or speed, of microtubule polymerization, i.e. the addition of tubulin dimers to a microtubule, is normal (i.e. indistinguishable from wild type)." [PMID:23051734, PomBase:mah] synonym: "normal microtubule polymerization rate" EXACT [PomBase:mah] synonym: "normal rate of microtubule polymerization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal rate of microtubule polymerization during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000899 ! normal microtubule cytoskeleton organization is_a: FYPO:0001215 ! normal protein complex assembly is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate intersection_of: inheres_in GO:0046785 ! microtubule polymerization intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0046785 ! microtubule polymerization relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-03-25T13:42:28Z [Term] id: FYPO:0003226 name: delayed protein localization to mitotic spindle def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the mitotic spindle begins later than normal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "delayed protein localisation to mitotic spindle" EXACT [PomBase:mah] synonym: "delayed protein mitotic spindle to mitotic spindle during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002824 ! abnormal protein localization to mitotic spindle is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902480 ! protein localization to mitotic spindle relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902480 ! protein localization to mitotic spindle created_by: midori creation_date: 2014-03-25T13:51:32Z [Term] id: FYPO:0003227 name: cytoplasmic microtubules present during mitosis def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the long cytoplasmic microtubules characteristic of interphase cells remain present after mitosis begins and the mitotic spindle forms." [PMID:18799626, PomBase:mah] synonym: "cytoplasmic microtubules present during mitotic M phase" EXACT [PomBase:mah] synonym: "cytoplasmic microtubules present during mitotic nuclear division" EXACT [GO:0007067] synonym: "interphase cytoplasmic microtubules present during mitosis" EXACT [PomBase:mah] is_a: FYPO:0004315 ! abnormal microtubule cytoskeleton during vegetative growth created_by: midori creation_date: 2014-03-25T13:59:34Z [Term] id: FYPO:0003228 name: abolished protein oxidation during cellular response to hydrogen peroxide def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the oxidation of one or more specific proteins, or of specific protein sites, does not occur during a cellular response to hydrogen peroxide." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein oxidation during cellular response to H2O2" EXACT [PomBase:mah] synonym: "abolished protein oxidation during cellular response to hydrogen peroxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein oxidation during cellular response to hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] synonym: "protein oxidation abolished during cellular response to hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000544 ! abolished protein modification during vegetative growth intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0070301 ! cellular response to hydrogen peroxide intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0018158 ! protein oxidation relationship: during GO:0070301 ! cellular response to hydrogen peroxide relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0018158 ! protein oxidation created_by: midori creation_date: 2014-03-25T14:29:42Z [Term] id: FYPO:0003229 name: abnormal hydrogen peroxide catabolism def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the chemical breakdown of hydrogen peroxide is abnormal." [GO:0042744, PomBase:mah] synonym: "abnormal H2O2 catabolic process" EXACT [GO:0042744] synonym: "abnormal H2O2 catabolism" EXACT [GO:0042744] synonym: "abnormal hydrogen peroxide catabolic process" EXACT [GO:0042744] is_a: FYPO:0000860 ! abnormal metabolic process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0042744 ! hydrogen peroxide catabolic process intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0042744 ! hydrogen peroxide catabolic process relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-03-25T14:33:16Z [Term] id: FYPO:0003230 name: decreased histone H3-K9 methylation at heterochromatin island def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which methylation of lysine at position 9 of histone H3 at heterochromatin islands occurs to a lower extent than normal." [PMID:24210919, PomBase:mah] synonym: "decreased histone H3 K9 methylation at heterochromatin island" EXACT [GO:0051567, PomBase:mah] synonym: "decreased histone H3-K9 methylation at heterochromatin island during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H3-K9 methylation at heterochromatin island during vegetative growth" EXACT [PomBase:mah] synonym: "decreased histone H3K9me at heterochromatin island" EXACT [GO:0051567, PomBase:mah] synonym: "decreased histone lysine H3 K9 methylation at heterochromatin island" EXACT [GO:0051567, PomBase:mah] synonym: "reduced histone H3-K9 methylation at heterochromatin island" EXACT [PomBase:mah] is_a: FYPO:0000872 ! decreased histone H3-K9 methylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051567 ! histone H3-K9 methylation intersection_of: occurs_in GO:1990342 ! heterochromatin island relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051567 ! histone H3-K9 methylation relationship: occurs_in GO:1990342 ! heterochromatin island created_by: midori creation_date: 2014-03-25T15:38:16Z [Term] id: FYPO:0003231 name: decreased histone H3-K9 methylation at heterochromatin domain def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which methylation of lysine at position 9 of histone H3 at heterochromatin domains occurs to a lower extent than normal." [PMID:24210919, PomBase:mah] synonym: "decreased histone H3 K9 methylation at heterochromatin domain" EXACT [GO:0051567, PomBase:mah] synonym: "decreased histone H3-K9 methylation at heterochromatin domain during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H3-K9 methylation at heterochromatin domain during vegetative growth" EXACT [PomBase:mah] synonym: "decreased histone H3-K9 methylation at HOODs" EXACT [PMID:24210919] synonym: "decreased histone H3K9me at heterochromatin domain" EXACT [GO:0051567, PomBase:mah] synonym: "decreased histone lysine H3 K9 methylation at heterochromatin domain" EXACT [GO:0051567, PomBase:mah] synonym: "reduced histone H3-K9 methylation at heterochromatin domain" EXACT [PomBase:mah] is_a: FYPO:0000872 ! decreased histone H3-K9 methylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051567 ! histone H3-K9 methylation intersection_of: occurs_in GO:1990343 ! heterochromatin domain relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051567 ! histone H3-K9 methylation relationship: occurs_in GO:1990343 ! heterochromatin domain created_by: midori creation_date: 2014-03-25T15:47:37Z [Term] id: FYPO:0003232 name: normal histone H3-K9 methylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which methylation of lysine at position 9 of histone H3 is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal histone H3 K9 methylation" EXACT [GO:0051567, PomBase:mah] synonym: "normal histone H3-K9 methylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal histone H3-K9 methylation during vegetative growth" EXACT [PomBase:mah] synonym: "normal histone H3K9me" EXACT [GO:0051567, PomBase:mah] synonym: "normal histone lysine H3 K9 methylation" EXACT [GO:0051567, PomBase:mah] is_a: FYPO:0000861 ! normal histone methylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051567 ! histone H3-K9 methylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051567 ! histone H3-K9 methylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-03-25T17:09:55Z [Term] id: FYPO:0003233 name: normal histone H3-K9 methylation at heterochromatin island def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which methylation of lysine at position 9 of histone H3 at heterochromatin islands is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal histone H3 K9 methylation at heterochromatin island" EXACT [GO:0051567, PomBase:mah] synonym: "normal histone H3-K9 methylation at heterochromatin island during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal histone H3-K9 methylation at heterochromatin island during vegetative growth" EXACT [PomBase:mah] synonym: "normal histone H3K9me at heterochromatin island" EXACT [GO:0051567, PomBase:mah] synonym: "normal histone lysine H3 K9 methylation at heterochromatin island" EXACT [GO:0051567, PomBase:mah] is_a: FYPO:0003232 ! normal histone H3-K9 methylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051567 ! histone H3-K9 methylation intersection_of: occurs_in GO:1990342 ! heterochromatin island intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051567 ! histone H3-K9 methylation relationship: occurs_in GO:1990342 ! heterochromatin island relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-03-25T17:11:22Z [Term] id: FYPO:0003234 name: normal histone H3-K9 methylation at heterochromatin domain def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which methylation of lysine at position 9 of histone H3 at heterochromatin domains is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal histone H3 K9 methylation at heterochromatin domain" EXACT [GO:0010452, PomBase:mah] synonym: "normal histone H3-K9 methylation at heterochromatin domain during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal histone H3-K9 methylation at heterochromatin domain during vegetative growth" EXACT [PomBase:mah] synonym: "normal histone H3-K9 methylation at HOOD" EXACT [PMID:24210919] synonym: "normal histone H3K9me at heterochromatin domain" EXACT [GO:0010452, PomBase:mah] synonym: "normal histone lysine H3 K9 methylation at heterochromatin domain" EXACT [GO:0010452, PomBase:mah] is_a: FYPO:0003232 ! normal histone H3-K9 methylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051567 ! histone H3-K9 methylation intersection_of: occurs_in GO:1990343 ! heterochromatin domain intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051567 ! histone H3-K9 methylation relationship: occurs_in GO:1990343 ! heterochromatin domain relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-03-25T17:12:02Z [Term] id: FYPO:0003235 name: normal histone H3-K9 methylation at centromere outer repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which methylation of lysine at position 9 of histone H3 at centromere outer repeat regions is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal histone H3 K9 methylation at centromere outer repeat" EXACT [GO:0010452, PomBase:mah] synonym: "normal histone H3-K9 methylation at centromere otr" EXACT [PomBase:mah] synonym: "normal histone H3-K9 methylation at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal histone H3-K9 methylation at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] synonym: "normal histone H3-K9 methylation at centromeric outer repeat region" EXACT [PMID:24210919] synonym: "normal histone H3-K9 methylation at pericentric region" RELATED [PomBase:mah] synonym: "normal histone H3-K9 methylation at pericentromeric region" RELATED [PomBase:mah] synonym: "normal histone H3K9me at centromere outer repeat" EXACT [GO:0010452, PomBase:mah] synonym: "normal histone lysine H3 K9 methylation at centromere outer repeat" EXACT [GO:0010452, PomBase:mah] is_a: FYPO:0003232 ! normal histone H3-K9 methylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051567 ! histone H3-K9 methylation intersection_of: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051567 ! histone H3-K9 methylation relationship: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-03-25T17:15:41Z [Term] id: FYPO:0003236 name: decreased transposable element-derived small RNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of small RNA (such as siRNA) derived from transposable element transcripts measured in a cell is lower than normal." [PMID:24095277, PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased accumulation of transposable element-derived small RNAs" RELATED [PomBase:vw] synonym: "decreased transposable element-derived small RNA accumulation" RELATED [PomBase:mah] synonym: "decreased transposable element-derived small RNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased transposable element-derived small RNA level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased transposon-derived small RNA level" EXACT [PomBase:mah] synonym: "reduced transposable element-derived small RNA level" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth created_by: midori creation_date: 2014-03-25T17:19:03Z [Term] id: FYPO:0003237 name: increased RNA splicing at cryptic splice sites def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of splicing of RNA primary transcripts at sites that are not normally frequently used (or not spliced at all) is increased." [PMID:24210919, PomBase:mah] synonym: "increased RNA splicing at cryptic splice sites during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased RNA splicing at cryptic splice sites during vegetative growth" EXACT [PomBase:mah] synonym: "increased RNA splicing of cryptic introns" EXACT [PMID:24210919] is_a: FYPO:0002916 ! increased RNA splicing intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile intersection_of: towards SO:0001533 ! cryptic_splice_site relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile relationship: towards SO:0001533 ! cryptic_splice_site created_by: midori creation_date: 2014-03-25T17:20:03Z [Term] id: FYPO:0003238 name: decreased anaerobic cell population growth def: "A vegetative cell population growth phenotype in which cell growth is decreased relative to normal under anaerobic conditions." [PomBase:mah] synonym: "decreased anaerobic vegetative cell population growth" EXACT [PomBase:mah] synonym: "reduced anaerobic cell population growth" EXACT [PomBase:mah] is_a: FYPO:0001355 ! decreased vegetative cell population growth created_by: midori creation_date: 2014-03-25T17:25:09Z [Term] id: FYPO:0003239 name: abnormal phosphodiesterase I activity def: "A molecular function phenotype in which the observed rate of phosphodiesterase I activity is abnormal." [PomBase:mah] is_a: FYPO:0003163 ! abnormal nuclease activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004528 ! phosphodiesterase I activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004528 ! phosphodiesterase I activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-03-25T17:27:12Z [Term] id: FYPO:0003240 name: decreased phosphodiesterase I activity def: "A molecular function phenotype in which the observed rate of phosphodiesterase I activity is decreased." [PomBase:mah] synonym: "reduced phosphodiesterase I activity" EXACT [PomBase:mah] is_a: FYPO:0003239 ! abnormal phosphodiesterase I activity is_a: FYPO:0004253 ! decreased nuclease activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004528 ! phosphodiesterase I activity relationship: inheres_in GO:0004528 ! phosphodiesterase I activity created_by: midori creation_date: 2014-03-25T17:27:18Z [Term] id: FYPO:0003241 name: unequal mitotic sister chromatid segregation def: "A cellular process phenotype in which mitotic sister chromatid segregation fails to separate chromosomes into two equal masses. Unequal mitotic sister chromatid separation may be complete, with two distinct unequal DNA masses located at or near the ends of an elongated mitotic spindle, or incomplete." [PomBase:mah] synonym: "mitotic chromosome nondisjunction" EXACT [PomBase:mah] synonym: "unequal mitotic chromosome segregation" EXACT [PomBase:mah] synonym: "unequal mitotic sister chromatid segregation during vegetative growth" EXACT [PomBase:mah] synonym: "unequal mitotic sister chromatid separation" RELATED [PomBase:mah] is_a: FYPO:0000141 ! abnormal mitotic sister chromatid segregation relationship: has_output FYPO:0004321 ! altered DNA level during vegetative growth created_by: midori creation_date: 2014-03-25T17:29:06Z [Term] id: FYPO:0003242 name: decreased splicing of mRNA introns with low A/U content def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of mRNA splicing via the spliceosome is decreased, where introns have low A/U content." [PMID:23754748, PomBase:mah] synonym: "decreased mRNA splicing, via spliceosome, introns with low A/U content" EXACT [PomBase:mah] synonym: "decreased nuclear mRNA splicing, via spliceosome, introns with low A/U content" EXACT [PomBase:mah] synonym: "decreased splicing of mRNA introns with low A/U content" BROAD [PomBase:al] synonym: "decreased splicing of mRNA introns with low A/U content during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased splicing of mRNA introns with low A/U content during vegetative growth" EXACT [PomBase:mah] synonym: "reduced splicing of mRNA introns with low A/U content" EXACT [PomBase:mah] is_a: FYPO:0003029 ! decreased mRNA splicing, via spliceosome created_by: midori creation_date: 2014-03-28T13:49:03Z [Term] id: FYPO:0003243 name: decreased splicing of long introns def: "A cellular process phenotype observed in the vegetative growth the occurrence of splicing of introns longer than about 45 nucleotides is decreased." [PMID:23754748, PomBase:mah] synonym: "decreased splicing of long introns during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased splicing of long introns during vegetative growth" EXACT [PomBase:mah] synonym: "reduced splicing of long introns" EXACT [PomBase:mah] is_a: FYPO:0003040 ! decreased RNA splicing created_by: midori creation_date: 2014-03-28T13:55:19Z [Term] id: FYPO:0003244 name: intron-specific abnormal mRNA splicing, via spliceosome def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mRNA splicing via the spliceosome takes place normally for some, but abnormally for other, specific introns." [PMID:23754748, PomBase:mah] synonym: "differential pre-mRNA splicing defects" EXACT [PMID:20400941] synonym: "intron-specific abnormal mRNA splicing, via spliceosome during mitotic cell cycle" RELATED [PomBase:mah] synonym: "intron-specific abnormal mRNA splicing, via spliceosome during vegetative growth" EXACT [PomBase:mah] synonym: "intron-specific abnormal nuclear mRNA splicing, via spliceosome" EXACT [PomBase:mah] synonym: "intron-specific mRNA splicing defects" EXACT [PomBase:al] is_a: FYPO:0000189 ! abnormal mRNA splicing, via spliceosome created_by: midori creation_date: 2014-03-28T14:09:33Z [Term] id: FYPO:0003245 name: telophase nuclear clustering def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the daughter nuclei formed by mitosis cluster in the middle of the cell during telophase. Normally, daughter nuclei move away from the cell division site during mitotic telophase." [PMID:23087209, PomBase:mah] comment: This phenotype may be observed when cytokinesis fails. synonym: "daughter nuclei clustered at cell division site during mitotic telophase" EXACT [PomBase:vw] synonym: "kissing nuclei" EXACT [PMID:23087209] synonym: "nuclear clustering during mitotic telophase" EXACT [PomBase:mah] synonym: "nuclei clustered at cell division site during mitotic telophase" EXACT [PomBase:vw] synonym: "telophase nuclear clustering during vegetative growth" RELATED [PomBase:mah] is_a: FYPO:0002071 ! mislocalized nucleus during vegetative growth relationship: output_of FYPO:0000417 ! abolished cytokinesis created_by: midori creation_date: 2014-03-28T14:35:02Z [Term] id: FYPO:0003246 name: normal mitotic S phase progression def: "A cellular process phenotype in which progression through S phase of the mitotic cell cycle is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal mitotic cell cycle progression in S" EXACT [PomBase:mah] synonym: "normal mitotic S phase progression during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002740 ! normal mitotic cell cycle phase intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000084 ! mitotic S phase intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000084 ! mitotic S phase relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-03-28T15:00:02Z [Term] id: FYPO:0003247 name: abolished histone H3 binding def: "A molecular function phenotype in which the binding of a protein to histone H3 does not occur." [PomBase:mah] comment: This term can be used for any protein-protein interaction that is affected by a mutation, whether or not the mutated gene product is one of the interacting proteins. We recommend noting which proteins were used in the assay when annotating to this term. synonym: "abolished protein-histone H3 interaction" EXACT [PomBase:mah] synonym: "histone H3 binding abolished" EXACT [PomBase:mah] is_a: FYPO:0000704 ! abnormal protein binding created_by: midori creation_date: 2014-03-28T15:03:01Z [Term] id: FYPO:0003248 name: increased level of histone H3 at centromere inner repeat def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of histone H3 measured at centromere inner repeat regions is higher than normal." [PMID:22291963, PomBase:mah] synonym: "increased level of histone H3 at imr" EXACT [PomBase:mah, SO:0001798] is_a: FYPO:0001327 ! increased protein level during vegetative growth created_by: midori creation_date: 2014-03-28T15:10:35Z [Term] id: FYPO:0003249 name: decreased level of histone H3 at dh repeat def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of histone H3 measured at centromeric dh repeat regions is lower than normal." [PMID:22291963, PomBase:mah] synonym: "reduced level of histone H3 at dh repeat" EXACT [PomBase:mah] is_a: FYPO:0004578 ! decreased level of histone H3 in cell created_by: midori creation_date: 2014-03-28T15:14:44Z [Term] id: FYPO:0003250 name: premature septation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which septation begins earlier than normal, e.g. before metaphase is complete." [PMID:23394829, PomBase:mah] synonym: "advanced septum formation" RELATED [PomBase:mah] synonym: "ectopic metaphase septation" RELATED [PMID:23394829] synonym: "premature barrier septum formation involved in mitotic cytokinesis" EXACT [PomBase:mah] synonym: "premature mitotic barrier septum assembly" EXACT [GO:0000917, PomBase:mah] synonym: "premature septation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000117 ! abnormal septation is_a: PATO:0000694 ! premature intersection_of: PATO:0000694 ! premature intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000917 ! barrier septum assembly relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000917 ! barrier septum assembly created_by: midori creation_date: 2014-03-28T15:22:36Z [Term] id: FYPO:0003251 name: decreased transcription from SRE promoter def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription from a promoter that contains one or more sterol regulatory elements (SREs) occurs to a lower extent than normal." [PMID:24327658, PomBase:mah] synonym: "decreased transcription from SRE promoter during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased transcription from SRE promoter during vegetative growth" EXACT [PomBase:mah] synonym: "decreased transcription from SRE-containing promoter" EXACT [PomBase:mah] synonym: "decreased transcription from sterol regulatory element-containing promoter" EXACT [PomBase:mah, SO:1861] synonym: "reduced transcription from SRE promoter" EXACT [PomBase:mah] is_a: FYPO:0000781 ! decreased transcription during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006351 ! transcription, DNA-templated intersection_of: occurs_at SO:0001861 ! sterol_regulatory_element relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006351 ! transcription, DNA-templated relationship: occurs_at SO:0001861 ! sterol_regulatory_element created_by: midori creation_date: 2014-03-28T15:30:32Z [Term] id: FYPO:0003252 name: abolished cell population growth on proline nitrogen source def: "A vegetative cell population growth phenotype in which a cell population does not grow in a medium containing L-proline as the nitrogen source." [PomBase:mah] comment: Use this term for a population of cells that does not grow with proline as the nitrogen source, but does grow using a different nitrogen source (a cell population that does not grow on any media would be considered inviable). Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "abolished growth on proline nitrogen source" BROAD [PomBase:mah] synonym: "abolished proline utilization" RELATED [PomBase:mah, PomBase:vw] synonym: "abolished vegetative cell population growth on proline nitrogen source" EXACT [PomBase:mah] synonym: "cell population growth on proline nitrogen source abolished" EXACT [PomBase:mah] is_a: FYPO:0001575 ! abolished vegetative cell population growth created_by: midori creation_date: 2014-04-01T11:30:43Z [Term] id: FYPO:0003253 name: abolished amino acid import during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of one or more amino acids into the cell is abolished." [PomBase:mah] synonym: "abolished amino acid import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished amino acid import into cell" EXACT [PomBase:al] synonym: "abolished amino acid uptake" EXACT [PomBase:mah] synonym: "amino acid import abolished" EXACT [PomBase:mah] is_a: FYPO:0001361 ! abnormal amino acid import during vegetative growth is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1902837 ! amino acid import into cell relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1902837 ! amino acid import into cell created_by: midori creation_date: 2014-04-01T11:42:23Z [Term] id: FYPO:0003254 name: abolished arginine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of arginine into the cell is abolished." [PomBase:mah] synonym: "abolished arginine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished arginine import during vegetative growth" EXACT [PomBase:mah] synonym: "abolished arginine import into cell" EXACT [PomBase:al] synonym: "abolished arginine uptake" EXACT [PomBase:mah] synonym: "abolished L-arginine import into cell" EXACT [PomBase:mah] synonym: "arginine import abolished" EXACT [PomBase:mah] is_a: FYPO:0003253 ! abolished amino acid import during vegetative growth intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1902765 ! L-arginine import into cell relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1902765 ! L-arginine import into cell created_by: midori creation_date: 2014-04-01T11:53:36Z [Term] id: FYPO:0003255 name: abolished proline import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of proline into the cell is abolished." [PomBase:mah] synonym: "abolished L-proline import into cell" NARROW [PomBase:mah] synonym: "abolished proline import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished proline import during vegetative growth" EXACT [PomBase:mah] synonym: "abolished proline import into cell" EXACT [PomBase:al] synonym: "abolished proline uptake" EXACT [PomBase:mah] synonym: "proline import abolished" EXACT [PomBase:mah] is_a: FYPO:0001361 ! abnormal amino acid import during vegetative growth is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1903809 ! L-proline import into cell relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1903809 ! L-proline import into cell created_by: midori creation_date: 2014-04-01T11:54:49Z [Term] id: FYPO:0003256 name: abnormal proline import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of proline into the cell is abnormal." [PomBase:mah] synonym: "abnormal L-proline import" EXACT [PomBase:mah] synonym: "abnormal proline import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal proline import during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal proline import into cell" EXACT [PomBase:al] synonym: "abnormal proline uptake" EXACT [PomBase:mah] is_a: FYPO:0001361 ! abnormal amino acid import during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1903809 ! L-proline import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1903809 ! L-proline import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-04-01T11:59:03Z [Term] id: FYPO:0003257 name: decreased proline import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of proline into the cell occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased L-proline import" EXACT [PomBase:mah] synonym: "decreased proline import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased proline import during vegetative growth" EXACT [PomBase:mah] synonym: "decreased proline import into cell" EXACT [PomBase:al] synonym: "decreased proline uptake" EXACT [PomBase:mah] synonym: "reduced proline import" EXACT [PomBase:mah] is_a: FYPO:0001360 ! decreased amino acid import during vegetative growth is_a: FYPO:0003256 ! abnormal proline import intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903809 ! L-proline import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903809 ! L-proline import into cell created_by: midori creation_date: 2014-04-01T11:59:16Z [Term] id: FYPO:0003258 name: increased proline import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of proline into the cell occurs to a greater extent than normal." [PomBase:mah] synonym: "decreased L-proline import" NARROW [PomBase:mah] synonym: "decreased proline import during vegetative growth" EXACT [PomBase:mah] synonym: "decreased proline import into cell" EXACT [PomBase:al] synonym: "decreased proline uptake" EXACT [PomBase:mah] synonym: "increased proline import during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0003169 ! increased amino acid import during vegetative growth is_a: FYPO:0003256 ! abnormal proline import intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903809 ! L-proline import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903809 ! L-proline import into cell created_by: midori creation_date: 2014-04-01T11:59:37Z [Term] id: FYPO:0003259 name: normal proline import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of proline into the cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal L-proline import" EXACT [PomBase:mah] synonym: "normal proline import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal proline import during vegetative growth" EXACT [PomBase:mah] synonym: "normal proline import into cell" EXACT [PomBase:al] synonym: "normal proline uptake" EXACT [PomBase:mah] is_a: FYPO:0001071 ! normal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903809 ! L-proline import into cell intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903809 ! L-proline import into cell relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-04-01T14:27:36Z [Term] id: FYPO:0003260 name: decreased RNA splicing at cryptic splice sites def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of splicing of RNA primary transcripts at sites that are not normally frequently used is decreased." [PMID:24210919, PomBase:mah] synonym: "decreased RNA splicing at cryptic splice sites during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased RNA splicing at cryptic splice sites during vegetative growth" EXACT [PomBase:mah] synonym: "decreased RNA splicing of cryptic introns" EXACT [PMID:24210919] synonym: "reduced RNA splicing at cryptic splice sites" EXACT [PomBase:mah] is_a: FYPO:0003040 ! decreased RNA splicing intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile intersection_of: towards SO:0001533 ! cryptic_splice_site relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile relationship: towards SO:0001533 ! cryptic_splice_site created_by: midori creation_date: 2014-04-01T14:33:51Z [Term] id: FYPO:0003261 name: decreased small RNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of small RNA measured in a cell is lower than normal. All types of small RNA, a particular RNA type, or a specific small RNA may be affected." [PMID:24095277, PomBase:mah] comment: This term was made obsolete because "small RNA" is not specific enough to indicate what type(s) of RNA is affected. synonym: "decreased accumulation of small RNAs" RELATED [PomBase:vw] synonym: "decreased small RNA accumulation" RELATED [PomBase:mah] synonym: "decreased small RNA level" RELATED [PomBase:mah] synonym: "decreased small RNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased small RNA level during vegetative growth" EXACT [PomBase:mah] synonym: "reduced small RNA level" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2014-04-01T14:36:05Z [Term] id: FYPO:0003262 name: increased small RNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of small RNA measured in a cell is greater than normal. All types of small RNA, a particular RNA type, or a specific small RNA may be affected." [PMID:24095277, PomBase:mah] comment: This term was made obsolete because "small RNA" is not specific enough to indicate what type(s) of RNA is affected. synonym: "increased accumulation of small RNAs" RELATED [PomBase:vw] synonym: "increased small RNA accumulation" RELATED [PomBase:mah] synonym: "increased small RNA level" RELATED [PomBase:mah] synonym: "increased small RNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased small RNA level during vegetative growth" EXACT [PomBase:mah] synonym: "reduced small RNA level" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2014-04-01T14:38:04Z [Term] id: FYPO:0003263 name: abnormal sporulation resulting in formation of ascus with more than four spores def: "A sporulation phenotype in which asci that contain more than four, and up to eight, spores form following conjugation and subsequent sporulation." [PMID:24196444, PomBase:mah, PomBase:vw] synonym: "8-spored asci" RELATED [PomBase:vw] synonym: "abnormal ascospore formation resulting in formation of asci with more than four spores" EXACT [GO:0030437, PomBase:mah] synonym: "abnormal sporulation resulting in formation of asci with more than four spores" EXACT [PomBase:mah] synonym: "asci with increased number of spores" EXACT [PomBase:vw] synonym: "eight-spored asci" RELATED [PomBase:vw] is_a: FYPO:0001894 ! abnormal sporulation resulting in formation of ascus with more or fewer than four spores created_by: midori creation_date: 2014-04-01T16:23:32Z [Term] id: FYPO:0003264 name: overlapping meiosis I spindles def: "A spindle phenotype in which the meiotic spindles in adjacent dividing nuclei overlap during meiosis I. The order of nuclei in the resulting ascus differs from normal as a result." [PMID:24196444, PomBase:mah] synonym: "overlapping spindles at meiosis I" EXACT [PomBase:vw] is_a: FYPO:0000734 ! abnormal meiotic spindle created_by: midori creation_date: 2014-04-02T14:41:20Z [Term] id: FYPO:0003265 name: normal alpha,alpha-trehalase activity increase during cellular response to heat stress def: "A molecular function phenotype in which the observed rate of alpha,alpha-trehalase activity increases normally (i.e. as in wild type) as a result of a heat stress." [PomBase:mah] synonym: "normal increase in trehalase activity in response to heat stress" EXACT [PomBase:al] synonym: "normal neutral trehalase activity increase during cellular response to heat stress" EXACT [PMID:9729425, PomBase:mah] synonym: "normal trehalase activity increase during cellular response to heat stress" BROAD [GO:0004555, GO:0015927] is_a: FYPO:0001480 ! normal alpha,alpha-trehalase activity created_by: midori creation_date: 2014-04-02T14:50:31Z [Term] id: FYPO:0003266 name: normal alpha,alpha-trehalase activity during cellular response to nutrient def: "A molecular function phenotype in which the observed rate of alpha,alpha-trehalase activity is normal (i.e. indistinguishable from wild type) during a cellular response to nutrient." [PomBase:mah] synonym: "normal alpha,alpha-trehalase activity in response to nutrient" EXACT [PomBase:al] synonym: "normal neutral trehalase activity during cellular response to nutrient" EXACT [PMID:9729425, PomBase:mah] synonym: "normal trehalase activity during cellular response to nutrient" BROAD [GO:0004555, GO:0015927] is_a: FYPO:0001480 ! normal alpha,alpha-trehalase activity intersection_of: PATO:0000001 ! quality intersection_of: during GO:0031670 ! cellular response to nutrient intersection_of: inheres_in GO:0004555 ! alpha,alpha-trehalase activity intersection_of: qualifier PATO:0000461 ! normal relationship: during GO:0031670 ! cellular response to nutrient relationship: inheres_in GO:0004555 ! alpha,alpha-trehalase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-04-02T14:51:45Z [Term] id: FYPO:0003267 name: normal acid phosphatase activity def: "A molecular function phenotype in which the observed rate of acid phosphatase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0004469 ! normal phosphatase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0003993 ! acid phosphatase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0003993 ! acid phosphatase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-04-02T14:57:53Z [Term] id: FYPO:0003268 name: decreased rate of mitotic spindle elongation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the rate, or speed, of mitotic spindle elongation is decreased." [PomBase:mah] synonym: "decreased rate of mitotic spindle elongation during vegetative growth" EXACT [PomBase:mah] synonym: "decreased rate of spindle elongation during mitosis" EXACT [PomBase:mah] synonym: "reduced rate of mitotic spindle elongation" EXACT [PomBase:mah] is_a: FYPO:0000131 ! abnormal mitotic spindle elongation is_a: PATO:0000911 ! decreased rate intersection_of: PATO:0000911 ! decreased rate intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000022 ! mitotic spindle elongation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000022 ! mitotic spindle elongation created_by: midori creation_date: 2014-04-02T15:03:47Z [Term] id: FYPO:0003269 name: abolished protein localization to microtubule during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to one or more microtubules does not occur." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to microtubule during vegetative growth" EXACT [PomBase:mah] synonym: "abolished protein localization to microtubule during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein absent from microtubule" RELATED [PomBase:mah] synonym: "protein localization to microtubule abolished" EXACT [PomBase:mah] is_a: FYPO:0000934 ! abolished protein localization to microtubule cytoskeleton during vegetative growth intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0035372 ! protein localization to microtubule relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0035372 ! protein localization to microtubule created_by: midori creation_date: 2014-04-02T15:25:45Z [Term] id: FYPO:0003270 name: growth auxotrophic for glutathione def: "Auxotrophy in which a cell is unable to synthesize glutathione, and therefore requires glutathione in the medium for vegetative cell growth." [PomBase:mah] synonym: "glutathione auxotrophy" EXACT [PomBase:mah] synonym: "growth auxotrophic for glutathione during mitotic cell cycle" RELATED [PomBase:mah] synonym: "growth auxotrophic for glutathione during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000128 ! auxotrophy created_by: midori creation_date: 2014-04-02T15:31:53Z [Term] id: FYPO:0003271 name: decreased cell population growth on methionine sulfur source def: "A vegetative cell population growth phenotype in which cell growth is decreased relative to normal in a medium containing L-methionine as the sole sulfur source." [PomBase:mah] comment: Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "decreased cell population growth on methionine sulphur source" EXACT [PomBase:mah] synonym: "decreased growth on methionine sulfur source" BROAD [PomBase:mah] synonym: "decreased methionine utilization" RELATED [PomBase:mah] synonym: "decreased vegetative cell population growth on methionine sulfur source" EXACT [PomBase:mah] synonym: "reduced cell population growth on methionine sulfur source" EXACT [PomBase:mah] is_a: FYPO:0001355 ! decreased vegetative cell population growth created_by: midori creation_date: 2014-04-02T15:32:50Z [Term] id: FYPO:0003272 name: normal growth on sodium hypochlorite def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing sodium hypochlorite." [PomBase:mah] synonym: "normal cell population growth in presence of sodium hypochlorite" EXACT [PomBase:mah] synonym: "normal cell population growth on NaOCl" EXACT [PomBase:al] synonym: "normal cell population growth on sodium hypochlorite" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to sodium hypochlorite" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on sodium hypochlorite" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:29222 ! hypochlorite relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:29222 ! hypochlorite created_by: midori creation_date: 2014-04-02T15:36:59Z [Term] id: FYPO:0003273 name: normal growth on nitrite def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing nitrite ions." [PomBase:mah] synonym: "normal cell population growth in presence of nitrite" EXACT [PomBase:mah] synonym: "normal cell population growth on nitrite" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cell population growth on nitrite ion" EXACT [PomBase:mah] synonym: "normal cellular response to nitrite" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on nitrite" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:16301 ! nitrite relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:16301 ! nitrite created_by: midori creation_date: 2014-04-02T15:41:59Z [Term] id: FYPO:0003274 name: normal growth on GSNO def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing S-nitrosoglutathione (GSNO)." [PomBase:mah] synonym: "normal cell population growth in presence of GSNO" EXACT [PomBase:mah] synonym: "normal cell population growth on GSNO" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cell population growth on S-nitrosoglutathione" EXACT [CHEBI:50091] synonym: "normal cellular response to GSNO" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on GSNO" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:50091 ! S-nitrosoglutathione relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:50091 ! S-nitrosoglutathione created_by: midori creation_date: 2014-04-02T15:42:47Z [Term] id: FYPO:0003275 name: sensitive to nitrite def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to nitrite ions. Cells stop growing (and may die) at a concentration of nitrite ions that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to nitrite" EXACT [PomBase:mah] synonym: "sensitive to nitrite during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to nitrite during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to nitrite ions" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:16301 ! nitrite relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:16301 ! nitrite created_by: midori creation_date: 2014-04-02T15:59:21Z [Term] id: FYPO:0003276 name: sensitive to sodium hypochlorite def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to sodium hypochlorite. Cells stop growing (and may die) at a concentration of sodium hypochlorite that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to sodium hypochlorite" EXACT [PomBase:mah] synonym: "sensitive to NaOCl" EXACT [PomBase:al] synonym: "sensitive to sodium hypochlorite during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to sodium hypochlorite during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:29222 ! hypochlorite relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:29222 ! hypochlorite created_by: midori creation_date: 2014-04-02T16:01:18Z [Term] id: FYPO:0003277 name: abolished protein localization to microtubule during mitosis def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to one or more microtubules does not occur during mitosis." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to microtubule during mitosis" EXACT [PomBase:mah] synonym: "abolished protein localization to microtubule during mitosis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to microtubule during mitosis during vegetative growth" EXACT [PomBase:mah] synonym: "abolished protein localization to microtubule during mitotic M phase" EXACT [PomBase:mah] synonym: "abolished protein localization to microtubule during mitotic nuclear division" EXACT [GO:0007067] synonym: "protein absent from microtubule during mitosis" RELATED [PomBase:mah] synonym: "protein localization to microtubule abolished during mitosis" EXACT [PomBase:mah] is_a: FYPO:0003269 ! abolished protein localization to microtubule during vegetative growth intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0007067 ! mitotic nuclear division intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0035372 ! protein localization to microtubule relationship: during GO:0007067 ! mitotic nuclear division relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0035372 ! protein localization to microtubule created_by: midori creation_date: 2014-04-02T16:07:17Z [Term] id: FYPO:0003278 name: abnormal plasma membrane def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the position or morphology of all or part of the plasma membrane is abnormal." [PomBase:mah] comment: Note that an abnormal plasma membrane organization process may, but does not necessarily, result in an abnormal plasma membrane. synonym: "abnormal plasma membrane during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal plasma membrane during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth intersection_of: PATO:0001241 ! physical object quality intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005886 ! plasma membrane intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005886 ! plasma membrane relationship: output_of FYPO:0000813 ! abnormal plasma membrane organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-04-02T16:11:20Z [Term] id: FYPO:0003279 name: excess Golgi cisternae present def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells contain more Golgi cisternae than normal. Golgi cisternae are the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GO:0031985, PomBase:mah] synonym: "accumulation of Golgi cisternae" EXACT [PomBase:vw] synonym: "excess Golgi cisternae present during mitotic cell cycle" RELATED [PomBase:mah] synonym: "excess Golgi cisternae present during vegetative growth" EXACT [PomBase:mah] synonym: "Golgi cisternae present in greater amount" EXACT [PomBase:mah] is_a: FYPO:0000349 ! abnormal Golgi morphology is_a: FYPO:0000354 ! abnormal endoplasmic reticulum morphology is_a: PATO:0002002 ! has extra parts of type intersection_of: PATO:0002002 ! has extra parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0031985 ! Golgi cisterna relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0031985 ! Golgi cisterna created_by: midori creation_date: 2014-04-03T14:07:34Z [Term] id: FYPO:0003280 name: decreased RNA level during cellular response to copper ion starvation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to copper ion starvation is lower than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased mRNA level during cellular response to copper ion starvation" NARROW [PomBase:mah] synonym: "decreased RNA accumulation during cellular response to copper ion starvation" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to copper ion depletion" EXACT [PomBase:vw] synonym: "decreased RNA level during cellular response to copper ion deprivation" EXACT [PomBase:vw] synonym: "decreased RNA level during cellular response to copper ion starvation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to copper ion starvation during vegetative growth" EXACT [PomBase:mah] synonym: "decreased RNA level during cellular response to copper starvation" EXACT [PomBase:mah] synonym: "decreased RNA level during copper ion starvation" EXACT [PomBase:al] synonym: "decreased transcript level during cellular response to copper ion starvation" EXACT [PomBase:vw] synonym: "reduced RNA level during cellular response to copper ion starvation" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth is_a: FYPO:0003197 ! altered RNA level during cellular response to copper ion starvation intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0035874 ! cellular response to copper ion starvation intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0035874 ! cellular response to copper ion starvation relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-04-03T14:16:46Z [Term] id: FYPO:0003281 name: abnormal superoxide dismutase activity def: "A molecular function phenotype in which the observed rate of superoxide dismutase activity is abnormal." [PomBase:mah] is_a: FYPO:0000689 ! abnormal oxidoreductase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004784 ! superoxide dismutase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004784 ! superoxide dismutase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-04-03T14:22:47Z [Term] id: FYPO:0003282 name: decreased superoxide dismutase activity def: "A molecular function phenotype in which the observed rate of superoxide dismutase activity is decreased." [PomBase:mah] synonym: "reduced superoxide dismutase activity" EXACT [PomBase:mah] is_a: FYPO:0000690 ! decreased oxidoreductase activity is_a: FYPO:0003281 ! abnormal superoxide dismutase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004784 ! superoxide dismutase activity relationship: inheres_in GO:0004784 ! superoxide dismutase activity created_by: midori creation_date: 2014-04-03T14:22:55Z [Term] id: FYPO:0003283 name: abnormal copper import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of copper ions into a cell is abnormal." [PomBase:mah] synonym: "abnormal cellular copper import" EXACT [PomBase:al] synonym: "abnormal copper cation import" EXACT [PomBase:mah] synonym: "abnormal copper import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal copper import during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal copper import into cell" EXACT [PomBase:mah] is_a: FYPO:0001336 ! transport phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0001720 ! abnormal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902861 ! copper ion import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902861 ! copper ion import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-04-03T14:28:41Z [Term] id: FYPO:0003284 name: decreased copper import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of copper ions into a cell occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased cellular copper import" EXACT [PomBase:al] synonym: "decreased copper cation import" EXACT [PomBase:mah] synonym: "decreased copper import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased copper import during vegetative growth" EXACT [PomBase:mah] synonym: "decreased copper import into cell" EXACT [PomBase:mah] synonym: "reduced copper import" EXACT [PomBase:mah] is_a: FYPO:0003283 ! abnormal copper import is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902861 ! copper ion import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902861 ! copper ion import into cell created_by: midori creation_date: 2014-04-03T14:28:49Z [Term] id: FYPO:0003285 name: decreased alpha,alpha-trehalase activity during cellular response to nutrient def: "A molecular function phenotype in which the observed rate of alpha,alpha-trehalase activity is lower than normal during a cellular response to nutrient." [PomBase:mah] synonym: "decreased neutral trehalase activity during cellular response to nutrient" EXACT [PMID:9729425, PomBase:mah] synonym: "decreased trehalase activity during cellular response to nutrient" BROAD [GO:0004555, GO:0015927] synonym: "reduced alpha,alpha-trehalase activity during cellular response to nutrient" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0001479 ! abnormal alpha,alpha-trehalase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: during GO:0031670 ! cellular response to nutrient intersection_of: inheres_in GO:0004555 ! alpha,alpha-trehalase activity relationship: during GO:0031670 ! cellular response to nutrient relationship: inheres_in GO:0004555 ! alpha,alpha-trehalase activity created_by: midori creation_date: 2014-04-03T14:46:28Z [Term] id: FYPO:0003286 name: decreased mitotic chromosome condensation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitotic chromosome condensation occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased mitotic chromosome condensation during vegetative growth" EXACT [PomBase:mah] synonym: "reduced mitotic chromosome condensation" EXACT [PomBase:mah] is_a: FYPO:0000159 ! abnormal chromosome condensation is_a: FYPO:0001346 ! DNA metabolism phenotype during vegetative growth is_a: FYPO:0001353 ! abnormal cellular component organization during vegetative growth is_a: FYPO:0001363 ! abnormal metabolic process during vegetative growth is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0007076 ! mitotic chromosome condensation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0007076 ! mitotic chromosome condensation created_by: midori creation_date: 2014-04-15T14:27:46Z [Term] id: FYPO:0003287 name: abnormal cell cycle arrest in meiotic interphase before premeiotic DNA replication def: "A cellular process phenotype in which progression through the meiotic cell cycle is arrested during the first meiotic interphase, before premeiotic DNA replication has taken place." [GO:0051328, PomBase:mah] synonym: "abnormal cell cycle arrest in meiotic interphase preceding premeiotic DNA replication" EXACT [PomBase:vw] synonym: "abnormal meiotic cell cycle arrest in interphase before premeiotic DNA replication" EXACT [PomBase:mah] is_a: FYPO:0002224 ! abnormally arrested meiotic cell cycle intersection_of: PATO:0001561 ! having extra processual parts intersection_of: during GO:0051328 ! meiotic interphase intersection_of: precedes GO:0006279 ! premeiotic DNA replication intersection_of: towards GO:0007050 ! cell cycle arrest relationship: during GO:0051328 ! meiotic interphase relationship: precedes GO:0006279 ! premeiotic DNA replication relationship: towards GO:0007050 ! cell cycle arrest created_by: midori creation_date: 2014-04-15T15:44:58Z [Term] id: FYPO:0003288 name: inviable after spore germination, without cell division, swollen multinucleate cell with central constriction def: "A phenotype in which a spore germinates to produce an inviable cell that does not divide, has a larger diameter and volume than normal, contains more than one nucleus, and has an abnormal shape featuring a constriction at the center of the cell, corresponding to the cell division site. In some such cells, the diameter at the ends is much greater than in wild-type cells." [PomBase:mah] synonym: "essential; germinating spore, without cell division, swollen multinucleate cell with central constriction" RELATED [PomBase:mah] synonym: "inviable after spore germination, undivided swollen multinucleate cell with central constriction" EXACT [PomBase:mah] synonym: "inviable after spore germination, without cell division, swollen dumbbell-shaped multinucleate cell" RELATED [PomBase:mah] synonym: "inviable after spore germination, without cell division, swollen multinucleate cell with central constriction, with nuclear division without cytokinesis" EXACT [PomBase:vw] synonym: "inviable after spore germination, without cell division, swollen multinucleate cell with constricted region at cell division site" EXACT [PomBase:vw] synonym: "inviable following spore germination, without cell division, swollen multinucleate cell with central constriction" EXACT [PomBase:mah] synonym: "inviable germinated spore, without cell division, swollen multinucleate cell with central constriction" EXACT [PomBase:mah] is_a: FYPO:0002987 ! inviable after spore germination, without cell division, swollen cell with central constriction created_by: midori creation_date: 2014-04-15T16:05:11Z [Term] id: FYPO:0003289 name: abnormal protein localization to medial cortical node def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the medial cortical nodes is abnormal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to medial cortical node" EXACT [PomBase:mah] synonym: "abnormal protein localization to cortical medial dot" EXACT [PMID:9105045, PomBase:vw] synonym: "abnormal protein localization to cytokinetic nodes" EXACT [PMID:24127216] synonym: "abnormal protein localization to medial cortical node during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein localization to medial cortical node during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal protein localization to medial cortical nodes" EXACT [PomBase:mah] is_a: FYPO:0000731 ! abnormal protein localization to medial cortex during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1902577 ! protein localization to medial cortical node intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1902577 ! protein localization to medial cortical node relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-04-15T16:09:09Z [Term] id: FYPO:0003290 name: abnormal glycoprotein glycan structure def: "A phenotype in which the structure of the glycan moiety of a glycoprotein differs from wild type." [PMID:9125114, PomBase:mah] is_a: FYPO:0001985 ! abnormal phenotype relationship: output_of FYPO:0001910 ! abnormal protein glycosylation created_by: midori creation_date: 2014-04-15T16:39:46Z [Term] id: FYPO:0003291 name: galactose absent from glycoprotein glycan def: "A phenotype in which the glycan moiety of a glycoprotein does not contain galactose residues. In wild-type cells, glycoprotein glycans contain mannose and galactose residues in a 1:1.2 ratio, and the galactose residues are connected by alpha-1,2 linkages." [PMID:9125114, PomBase:mah] synonym: "alpha 1,2-linked galactose residues absent from glycoprotein" EXACT [PMID:9125114, PomBase:vw] is_a: FYPO:0003290 ! abnormal glycoprotein glycan structure created_by: midori creation_date: 2014-04-15T16:40:45Z [Term] id: FYPO:0003292 name: abnormal UDP-galactose transmembrane transport def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which UDP-galactose transmembrane transport is abnormal." [PomBase:mah] synonym: "abnormal UDP-galactose transmembrane transport during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal UDP-galactose transmembrane transport during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001336 ! transport phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0001720 ! abnormal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0072334 ! UDP-galactose transmembrane transport intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0072334 ! UDP-galactose transmembrane transport relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-04-15T16:47:51Z [Term] id: FYPO:0003293 name: increased UDP-galactose transmembrane transport def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which UDP-galactose transmembrane transport occurs to a greater extent than normal." [PomBase:mah] synonym: "increased UDP-galactose transmembrane transport during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased UDP-galactose transmembrane transport during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003292 ! abnormal UDP-galactose transmembrane transport is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072334 ! UDP-galactose transmembrane transport relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072334 ! UDP-galactose transmembrane transport created_by: midori creation_date: 2014-04-15T16:48:09Z [Term] id: FYPO:0003294 name: normal UDP-galactose transmembrane transport def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which UDP-galactose transmembrane transport is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal UDP-galactose transmembrane transport during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal UDP-galactose transmembrane transport during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001071 ! normal transport is_a: FYPO:0001336 ! transport phenotype during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072334 ! UDP-galactose transmembrane transport intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072334 ! UDP-galactose transmembrane transport relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-04-15T16:50:17Z [Term] id: FYPO:0003295 name: normal growth on amitrole def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing amitrole." [PomBase:mah] synonym: "normal cell population growth in presence of amitrole" EXACT [PomBase:mah] synonym: "normal cell population growth on 3-amino-1,2,4-triazole" EXACT [CHEBI:40036, PomBase:mah] synonym: "normal cell population growth on 3-AT" EXACT [PomBase:mah] synonym: "normal cell population growth on 3AT" EXACT [PMID:23671279] synonym: "normal cell population growth on amitrole" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to amitrole" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on amitrole" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:40036 ! amitrole relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:40036 ! amitrole created_by: midori creation_date: 2014-04-16T16:23:41Z [Term] id: FYPO:0003296 name: normal ribosome binding def: "A molecular function phenotype in which occurrence of ribosome binding by a gene product (usually a protein) in a mutant is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000706 ! normal molecular function is_a: FYPO:0001092 ! binding phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0043022 ! ribosome binding intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0043022 ! ribosome binding relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-04-16T16:27:17Z [Term] id: FYPO:0003297 name: abolished ribosome binding def: "A molecular function phenotype in which ribosome binding by a gene product does not occur. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "ribosome binding abolished" EXACT [PomBase:mah] is_a: FYPO:0001092 ! binding phenotype is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0043022 ! ribosome binding relationship: towards GO:0043022 ! ribosome binding created_by: midori creation_date: 2014-04-16T16:27:57Z [Term] id: FYPO:0003298 name: decreased protein autophosphorylation during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of autophosphorylation of one or more specific proteins, or of specific protein sites, is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein autophosphorylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "reduced protein autophosphorylation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001838 ! decreased protein phosphorylation during vegetative growth is_a: FYPO:0003019 ! abnormal protein autophosphorylation during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0046777 ! protein autophosphorylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0046777 ! protein autophosphorylation created_by: midori creation_date: 2014-04-16T16:28:34Z [Term] id: FYPO:0003299 name: normal protein degradation via N-end rule pathway during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which ubiquitin-dependent protein degradation via the N-end rule pathway is normal (i.e. indistinguishable from wild type). In the N-end rule pathway, destabilizing N-terminal residues (N-degrons) in substrates are recognized by E3 ligases (N-recognins), whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation." [GO:0071596, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein degradation via N-end rule pathway during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal ubiquitin-dependent protein breakdown via the N-end rule pathway during vegetative growth" EXACT [GO:0071596, PomBase:mah] synonym: "normal ubiquitin-dependent protein catabolic process via the N-end rule pathway during vegetative growth" EXACT [GO:0071596] synonym: "normal ubiquitin-dependent protein catabolism via the N-end rule pathway during vegetative growth" EXACT [GO:0071596, PomBase:mah] synonym: "normal ubiquitin-dependent protein degradation via the N-end rule pathway during vegetative growth" EXACT [GO:0071596, PomBase:mah] is_a: FYPO:0000859 ! normal metabolic process during vegetative growth is_a: FYPO:0002800 ! normal protein degradation during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071596 ! ubiquitin-dependent protein catabolic process via the N-end rule pathway intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071596 ! ubiquitin-dependent protein catabolic process via the N-end rule pathway relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-04-16T16:37:32Z [Term] id: FYPO:0003300 name: decreased protein degradation via N-end rule pathway during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of ubiquitin-dependent protein degradation via the N-end rule pathway is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein degradation via N-end rule pathway during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased ubiquitin-dependent protein breakdown via the N-end rule pathway during vegetative growth" EXACT [GO:0071596] synonym: "decreased ubiquitin-dependent protein catabolic process via the N-end rule pathway during vegetative growth" EXACT [GO:0071596] synonym: "decreased ubiquitin-dependent protein catabolism via the N-end rule pathway during vegetative growth" EXACT [GO:0071596, PomBase:mah] synonym: "decreased ubiquitin-dependent protein degradation via the N-end rule pathway during vegetative growth" EXACT [GO:0071596, PomBase:mah] synonym: "reduced protein degradation via N-end rule pathway during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0004545 ! decreased proteasomal ubiquitin-dependent protein degradation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071596 ! ubiquitin-dependent protein catabolic process via the N-end rule pathway relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071596 ! ubiquitin-dependent protein catabolic process via the N-end rule pathway created_by: midori creation_date: 2014-04-16T16:41:59Z [Term] id: FYPO:0003301 name: delayed protein degradation via N-end rule pathway during meiosis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which ubiquitin-dependent protein degradation via the N-end rule pathway begins later than normal during one or both meiotic nuclear divisions." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "delayed ubiquitin-dependent protein breakdown via the N-end rule pathway during meiosis" EXACT [GO:0071596] synonym: "delayed ubiquitin-dependent protein catabolic process via the N-end rule pathway during meiosis" EXACT [GO:0071596] synonym: "delayed ubiquitin-dependent protein catabolism via the N-end rule pathway during meiosis" EXACT [GO:0071596, PomBase:mah] synonym: "delayed ubiquitin-dependent protein degradation via the N-end rule pathway during meiosis" EXACT [GO:0071596, PomBase:mah] is_a: FYPO:0002275 ! abnormal protein degradation is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0007126 ! meiotic nuclear division intersection_of: inheres_in GO:0071596 ! ubiquitin-dependent protein catabolic process via the N-end rule pathway relationship: happens_during GO:0007126 ! meiotic nuclear division relationship: inheres_in GO:0071596 ! ubiquitin-dependent protein catabolic process via the N-end rule pathway created_by: midori creation_date: 2014-04-16T16:44:49Z [Term] id: FYPO:0003302 name: nucleus mislocalized towards cell tip during interphase def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the nucleus is located near one cell tip (instead of at the midpoint of the long axis of the cell) during interphase." [PMID:9348288, PomBase:mah] synonym: "displaced interphase nucleus" RELATED [PomBase:vw] synonym: "displaced premitotic nucleus" RELATED [PomBase:vw] synonym: "interphase nucleus mislocalized to cell tip" EXACT [PomBase:vw] synonym: "nucleus mislocalised to cell tip during interphase" EXACT [PomBase:mah] synonym: "off-centre interphase nucleus" EXACT [PomBase:vw] synonym: "off-centre premitotic nucleus" EXACT [PomBase:vw] is_a: FYPO:0002071 ! mislocalized nucleus during vegetative growth created_by: midori creation_date: 2014-04-23T11:11:11Z [Term] id: FYPO:0003303 name: mislocalized post-anaphase array def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the post-anaphase array of microtubules is present in an abnormal location." [PMID:9348288, PomBase:mah] synonym: "mislocalised post-anaphase array" EXACT [PomBase:mah] synonym: "mislocalized PAA" EXACT [PomBase:mah] synonym: "mislocalized post-anaphase microtubule array" EXACT [PomBase:mah] is_a: FYPO:0004316 ! abnormal post-anaphase array is_a: PATO:0000628 ! mislocalised intersection_of: PATO:0000628 ! mislocalised intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990295 ! post-anaphase microtubule array relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990295 ! post-anaphase microtubule array created_by: midori creation_date: 2014-04-23T11:29:00Z [Term] id: FYPO:0003304 name: abnormal mitotic spindle midzone assembly def: "A microtubule cytoskeleton organization phenotype observed in the vegetative growth phase of the life cycle in which formation of the mitotic spindle midzone, the area in the center of the mitotic spindle where the spindle microtubules from opposite poles overlap, is abnormal." [GO:0051256, PomBase:mah] synonym: "abnormal mitotic spindle midzone assembly during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal spindle midzone assembly involved in mitosis" EXACT [GO:0051256] is_a: FYPO:0001350 ! abnormal microtubule cytoskeleton organization during vegetative growth is_a: FYPO:0001354 ! abnormal cellular component assembly during vegetative growth is_a: FYPO:0002737 ! abnormal mitotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0051256 ! mitotic spindle midzone assembly intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0051256 ! mitotic spindle midzone assembly relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-04-23T11:37:40Z [Term] id: FYPO:0003305 name: separate mitotic half spindles present def: "A spindle phenotype in which polar microtubules fail to interdigitate properly, and two partially or completely separated microtubule structures, usually V-shaped, each corresponding to one half of the spindle, are present." [PMID:9348288, PomBase:mah] synonym: "broken spindle interzone" RELATED [PMID:11694582] synonym: "broken spindle midzone" RELATED [PomBase:mah] synonym: "loss of interdigitation between mitotic half spindles" EXACT [PomBase:vw] synonym: "separate half spindles present during mitosis" EXACT [PomBase:mah] synonym: "separate mitotic half spindles present during vegetative growth" EXACT [PomBase:mah] synonym: "spindle fraying" RELATED [PMID:9348288] is_a: FYPO:0000338 ! abnormal mitotic spindle relationship: output_of FYPO:0003304 ! abnormal mitotic spindle midzone assembly created_by: midori creation_date: 2014-04-23T11:42:54Z [Term] id: FYPO:0003306 name: decreased mitotic index def: "A cell population phenotype in which the mitotic index is lower than normal. The mitotic index is the proportion of the population undergoing mitosis at any given time." [PMID:11683392, PMID:22684255, PomBase:mah] synonym: "reduced mitotic index" EXACT [PomBase:mah] is_a: FYPO:0000003 ! cell population phenotype is_a: FYPO:0001985 ! abnormal phenotype created_by: midori creation_date: 2014-04-23T14:26:21Z [Term] id: FYPO:0003307 name: increased mitotic index def: "A cell population phenotype in which the mitotic index is higher than normal. The mitotic index is the proportion of the population undergoing mitosis at any given time." [PMID:11683392, PMID:22684255, PomBase:mah] comment: Mitotic index is typically determined by microscopy, either by using tubulin immunofluorescence to detect spindles, or by using DAPI staining to detect DNA, where the presence of two nuclei but no septum is interpreted as anaphase. is_a: FYPO:0000003 ! cell population phenotype is_a: FYPO:0001985 ! abnormal phenotype created_by: midori creation_date: 2014-04-23T14:26:27Z [Term] id: FYPO:0003308 name: normal protein localization to mitotic spindle pole body during interphase def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the mitotic spindle pole body is normal (i.e. indistinguishable from wild type) during interphase of the cell cycle." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to mitotic spindle pole body during interphase" EXACT [PomBase:mah] synonym: "normal protein localization to mitotic SPB during interphase" EXACT [PomBase:mah] synonym: "normal protein localization to mitotic spindle pole body during mitotic interphase" EXACT [PomBase:mah] synonym: "normal protein localization to spindle pole body during interphase during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002967 ! normal protein localization to mitotic spindle pole body intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0051329 ! mitotic interphase intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902440 ! protein localization to mitotic spindle pole body intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0051329 ! mitotic interphase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902440 ! protein localization to mitotic spindle pole body relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-04-23T14:46:59Z [Term] id: FYPO:0003309 name: abnormal IMP cyclohydrolase activity def: "A molecular function phenotype in which the observed rate of IMP cyclohydrolase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0003937 ! IMP cyclohydrolase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0003937 ! IMP cyclohydrolase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-04-23T14:50:12Z [Term] id: FYPO:0003310 name: abolished IMP cyclohydrolase activity def: "A molecular function phenotype in which IMP cyclohydrolase activity is absent." [PomBase:mah] synonym: "IMP cyclohydrolase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0003309 ! abnormal IMP cyclohydrolase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0003937 ! IMP cyclohydrolase activity relationship: towards GO:0003937 ! IMP cyclohydrolase activity created_by: midori creation_date: 2014-04-23T14:50:25Z [Term] id: FYPO:0003311 name: abnormal phosphoribosylaminoimidazolecarboxamide formyltransferase activity def: "A molecular function phenotype in which the observed rate of phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR formyltransferase) activity is abnormal." [PomBase:mah] synonym: "abnormal AICAR formyltransferase activity" EXACT [GO:0004643] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004643 ! phosphoribosylaminoimidazolecarboxamide formyltransferase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004643 ! phosphoribosylaminoimidazolecarboxamide formyltransferase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-04-23T14:50:45Z [Term] id: FYPO:0003312 name: abolished phosphoribosylaminoimidazolecarboxamide formyltransferase activity def: "A molecular function phenotype in which phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR formyltransferase) activity is absent." [PomBase:mah] synonym: "abolished AICAR formyltransferase activity" EXACT [GO:0004643] synonym: "phosphoribosylaminoimidazolecarboxamide formyltransferase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0003311 ! abnormal phosphoribosylaminoimidazolecarboxamide formyltransferase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0004643 ! phosphoribosylaminoimidazolecarboxamide formyltransferase activity relationship: towards GO:0004643 ! phosphoribosylaminoimidazolecarboxamide formyltransferase activity created_by: midori creation_date: 2014-04-23T14:50:51Z [Term] id: FYPO:0003313 name: inviable after spore germination, without cell division, mononucleate cell with elongated germ tube def: "A phenotype in which a spore germinates to produce an elongated germ tube, and in which the nucleus does not divide. The cell does not divide, and eventually dies." [PomBase:mah] synonym: "essential; germinating spore without cell division, mononucleate cell with elongated germ tube" RELATED [PomBase:mah] synonym: "inviable after spore germination, without cell division, elongated mononucleate cell" EXACT [PomBase:mah] synonym: "inviable germinated spore, without cell division, mononucleate cell with elongated germ tube" EXACT [PomBase:mah] synonym: "inviable mononucleate germinated spore with elongated germ tube" EXACT [PomBase:mah] synonym: "mononucleate after spore germination with elongated germ tube" EXACT [PomBase:vw] is_a: FYPO:0002379 ! inviable after spore germination, without cell division, with elongated germ tube created_by: midori creation_date: 2014-04-23T14:56:10Z [Term] id: FYPO:0003314 name: activation of monopolar cell growth at new end def: "A regulation phenotype observed in the vegetative growth phase of the life cycle in which the activation of monopolar cell growth occurs at the new end of the cell, instead of at the old end, following cell division." [PomBase:mah] synonym: "abnormal initiation of growth from new end following cell division" EXACT [PomBase:mah] synonym: "activation of monopolar vegetative cell growth at new end" EXACT [PomBase:mah] is_a: FYPO:0001393 ! abnormal activation of monopolar cell growth created_by: midori creation_date: 2014-04-23T16:13:44Z [Term] id: FYPO:0003315 name: actin cables absent from cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the cell does not contain detectable actin cables." [PomBase:mah] synonym: "absent actin cables" EXACT [PomBase:mah] synonym: "actin filament bundles absent from cell" EXACT [PomBase:mah] is_a: FYPO:0002398 ! abnormal actin cytoskeleton during vegetative growth is_a: PATO:0002000 ! lacks all parts of type intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards GO:0032432 ! actin filament bundle relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards GO:0032432 ! actin filament bundle created_by: midori creation_date: 2014-04-23T16:18:19Z [Term] id: FYPO:0003316 name: normal protein localization to growing cell tip def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the growing cell tip is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to growing cell tip" EXACT [PomBase:mah] synonym: "normal protein localization to growing cell tip during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to growing cell tip during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001587 ! normal protein localization to cell tip intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902486 ! protein localization to growing cell tip intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902486 ! protein localization to growing cell tip relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-04-23T16:20:28Z [Term] id: FYPO:0003317 name: decreased protein localization to growing cell tip, with protein distributed in plasma membrane or cortex def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to a growing cell tip is decreased, and the protein is also detected distributed throughout the plasma membrane and/or cell cortex." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to growing cell tip, with protein distributed in plasma membrane or cortex" EXACT [PomBase:mah] synonym: "decreased protein localization to growing cell tip during vegetative growth, with protein distributed in plasma membrane or cortex" EXACT [PomBase:mah] synonym: "decreased protein localization to growing cell tip, with protein distributed in cell cortex" NARROW [PomBase:mah] synonym: "decreased protein localization to growing cell tip, with protein distributed in cell membrane or cortex" EXACT [PomBase:mah] synonym: "decreased protein localization to growing cell tip, with protein distributed in plasma membrane" NARROW [PomBase:mah] synonym: "decreased protein localization to growing cell tip, with protein distributed in plasma membrane or cortex during mitotic cell cycle" RELATED [PomBase:mah] synonym: "reduced protein localization to growing cell tip, with protein distributed in plasma membrane or cortex" EXACT [PomBase:mah] is_a: FYPO:0002871 ! decreased protein localization to growing cell tip created_by: midori creation_date: 2014-04-23T16:24:17Z [Term] id: FYPO:0003318 name: abolished galactose-specific cell-cell adhesion def: "A cell adhesion phenotype observed in the vegetative growth phase of the life cycle in which galactose-specific cell-cell adhesion does not occur. Galactose-specific cell-cell adhesion is the attachment of one cell to another cell, mediated via the binding of cell wall proteins on one cell to galactose residues on the other." [GO:0098611, PomBase:mah] synonym: "abolished cell-cell adhesion involved in galactose-specific flocculation" NARROW [GO:0098611] synonym: "abolished galactose-specific cell-cell adhesion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "galactose-specific cell-cell adhesion abolished" EXACT [PomBase:mah] synonym: "galactose-specific cell-cell adhesion abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000009 ! abnormal cell adhesion during vegetative growth is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0098611 ! cell-cell adhesion involved in galactose-specific flocculation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0098611 ! cell-cell adhesion involved in galactose-specific flocculation created_by: midori creation_date: 2014-04-29T11:01:09Z [Term] id: FYPO:0003319 name: increased mannose-specific cell-cell adhesion def: "A cell adhesion phenotype observed in the vegetative growth phase of the life cycle in which mannose-specific cell-cell adhesion is increased. Mannose-specific cell-cell adhesion is the attachment of one cell to another cell, mediated via the binding of cell wall proteins on one cell to mannose residues on the other, and when it is increased cells adhere to each other more strongly or to a greater extent than normal." [GO:0098612, PomBase:mah] synonym: "increased cell-cell adhesion involved in mannose-specific flocculation" NARROW [GO:0098612] synonym: "increased mannose-specific cell-cell adhesion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased mannose-specific cell-cell adhesion during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000009 ! abnormal cell adhesion during vegetative growth is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0098612 ! cell-cell adhesion involved in mannose-specific flocculation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0098612 ! cell-cell adhesion involved in mannose-specific flocculation created_by: midori creation_date: 2014-04-29T11:01:15Z [Term] id: FYPO:0003320 name: abnormal NADH dehydrogenase (ubiquinone) activity def: "A molecular function phenotype in which the observed rate of NADH dehydrogenase (ubiquinone) activity is abnormal." [PomBase:mah] comment: Also consider using the cellular process phenotype term 'abnormal cellular respiration' (FYPO:0000078). is_a: FYPO:0000689 ! abnormal oxidoreductase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0008137 ! NADH dehydrogenase (ubiquinone) activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0008137 ! NADH dehydrogenase (ubiquinone) activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-04-29T11:20:47Z [Term] id: FYPO:0003321 name: decreased NADH dehydrogenase (ubiquinone) activity def: "A molecular function phenotype in which the observed rate of NADH dehydrogenase (ubiquinone) activity is decreased." [PomBase:mah] comment: Also consider using the cellular process phenotype term 'decreased cellular respiration' (FYPO:0000342). synonym: "reduced NADH dehydrogenase (ubiquinone) activity" EXACT [PomBase:mah] is_a: FYPO:0000690 ! decreased oxidoreductase activity is_a: FYPO:0003320 ! abnormal NADH dehydrogenase (ubiquinone) activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0008137 ! NADH dehydrogenase (ubiquinone) activity relationship: inheres_in GO:0008137 ! NADH dehydrogenase (ubiquinone) activity created_by: midori creation_date: 2014-04-29T11:20:55Z [Term] id: FYPO:0003322 name: abnormal succinate dehydrogenase (ubiquinone) activity def: "A molecular function phenotype in which the observed rate of succinate dehydrogenase (ubiquinone) activity is abnormal." [PomBase:mah] comment: Also consider using the cellular process phenotype term 'abnormal cellular respiration' (FYPO:0000078). is_a: FYPO:0000689 ! abnormal oxidoreductase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0008177 ! succinate dehydrogenase (ubiquinone) activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0008177 ! succinate dehydrogenase (ubiquinone) activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-04-29T11:21:16Z [Term] id: FYPO:0003323 name: abolished succinate dehydrogenase (ubiquinone) activity def: "A molecular function phenotype in which succinate dehydrogenase (ubiquinone) activity is absent." [PomBase:mah] comment: Also consider using the cellular process phenotype term 'decreased cellular respiration' (FYPO:0000342). synonym: "succinate dehydrogenase (ubiquinone) activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0003322 ! abnormal succinate dehydrogenase (ubiquinone) activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0008177 ! succinate dehydrogenase (ubiquinone) activity relationship: towards GO:0008177 ! succinate dehydrogenase (ubiquinone) activity created_by: midori creation_date: 2014-04-29T11:21:37Z [Term] id: FYPO:0003324 name: altered cytochrome absorption spectrum def: "A phenotype in which the spectrum of light absorption observed in whole cells or isolated mitochondria, and attributed to cytochromes present, differs from wild type." [PMID:22349564, PMID:8668131, PomBase:mah] synonym: "altered mitochondrial absorption spectrum" RELATED [PomBase:mah] is_a: FYPO:0001985 ! abnormal phenotype created_by: midori creation_date: 2014-04-29T11:59:47Z [Term] id: FYPO:0003325 name: resistance to methotrexate def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of methotrexate than normal." [PomBase:mah] synonym: "resistance to methotrexate during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to methotrexate during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to methotrexate" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:44185 ! methotrexate relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:44185 ! methotrexate created_by: midori creation_date: 2014-04-29T13:18:48Z [Term] id: FYPO:0003326 name: normal interphase microtubule nucleation def: "A microtubule cytoskeleton organization phenotype observed in the vegetative growth phase of the life cycle in which nucleation of microtubules from interphase microtubule organizing centers (iMTOCs) is normal (i.e. indistinguishable from wild type)." [PMID:19001497, PomBase:mah] synonym: "normal interphase microtubule nucleation by interphase microtubule organizing center" EXACT [PomBase:mah] synonym: "normal interphase microtubule nucleation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal interphase microtubule nucleation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000899 ! normal microtubule cytoskeleton organization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051415 ! interphase microtubule nucleation by interphase microtubule organizing center intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051415 ! interphase microtubule nucleation by interphase microtubule organizing center relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-04-29T13:48:16Z [Term] id: FYPO:0003327 name: curved cytoplasmic microtubules def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells form cytoplasmic microtubules that are curved, i.e. follow a smooth bend rather than a straight line." [PomBase:mah] synonym: "curved cytoplasmic microtubules during mitotic cell cycle" RELATED [PomBase:mah] synonym: "curved cytoplasmic microtubules during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001418 ! abnormal microtubule cytoskeleton morphology during vegetative growth is_a: FYPO:0004088 ! abnormal cytoplasmic microtubules is_a: PATO:0000406 ! curved intersection_of: PATO:0000406 ! curved intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005881 ! cytoplasmic microtubule relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005881 ! cytoplasmic microtubule created_by: midori creation_date: 2014-04-29T13:51:48Z [Term] id: FYPO:0003328 name: misoriented cytoplasmic microtubules def: "A microtubule organization phenotype observed in the vegetative growth phase of the life cycle in which the orientation of cytoplasmic microtubules within a cell is abnormal. The normal orientation is parallel to the long axis of the cell." [PomBase:mah] synonym: "misoriented cytoplasmic microtubules during mitotic cell cycle" RELATED [PomBase:mah] synonym: "misoriented cytoplasmic microtubules during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0004088 ! abnormal cytoplasmic microtubules is_a: PATO:0000133 ! orientation intersection_of: PATO:0000133 ! orientation intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005881 ! cytoplasmic microtubule relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005881 ! cytoplasmic microtubule created_by: midori creation_date: 2014-04-29T13:53:11Z [Term] id: FYPO:0003329 name: abolished protein localization to cell tip during mitotic interphase def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the cell tip is abolished during interphase of the mitotic cell cycle." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to cell tip during mitotic interphase" EXACT [PomBase:mah] synonym: "abolished protein localization to cell tip during mitotic interphase during vegetative growth" EXACT [PomBase:mah] synonym: "protein localization to cell tip abolished during mitotic interphase" EXACT [PomBase:mah] is_a: FYPO:0001585 ! abolished protein localization to cell tip intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0051329 ! mitotic interphase intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1990151 ! protein localization to cell tip relationship: during GO:0051329 ! mitotic interphase relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1990151 ! protein localization to cell tip created_by: midori creation_date: 2014-04-29T13:58:27Z [Term] id: FYPO:0003330 name: normal protein localization to new mitotic spindle pole body def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the new mitotic spindle pole body is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal asymmetric protein localization to new mitotic spindle pole body" EXACT [GO:0061510] synonym: "normal protein localisation to new mitotic spindle pole body" EXACT [PomBase:mah] synonym: "normal protein localization to new mitotic SPB" EXACT [PomBase:mah] synonym: "normal protein localization to new spindle pole body during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002967 ! normal protein localization to mitotic spindle pole body intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0061510 ! asymmetric protein localization to new mitotic spindle pole body intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0061510 ! asymmetric protein localization to new mitotic spindle pole body relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-04-29T14:04:57Z [Term] id: FYPO:0003331 name: decreased protein kinase activity during mitotic interphase def: "A molecular function phenotype in which the observed rate of a protein kinase activity is decreased during interphase of the mitotic cell cycle." [PomBase:mah] synonym: "reduced protein kinase activity during mitotic interphase" EXACT [PomBase:mah] is_a: FYPO:0001382 ! decreased protein kinase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: during GO:0051329 ! mitotic interphase intersection_of: inheres_in GO:0004672 ! protein kinase activity relationship: during GO:0051329 ! mitotic interphase relationship: inheres_in GO:0004672 ! protein kinase activity created_by: midori creation_date: 2014-04-29T14:07:34Z [Term] id: FYPO:0003332 name: normal protein kinase activity during mitotic interphase def: "A molecular function phenotype in which the observed rate of a protein kinase activity is normal (i.e. indistinguishable from wild type) during interphase of the mitotic cell cycle." [PomBase:mah] is_a: FYPO:0003075 ! normal protein kinase activity intersection_of: PATO:0000001 ! quality intersection_of: during GO:0051329 ! mitotic interphase intersection_of: inheres_in GO:0004672 ! protein kinase activity intersection_of: qualifier PATO:0000461 ! normal relationship: during GO:0051329 ! mitotic interphase relationship: inheres_in GO:0004672 ! protein kinase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-04-29T14:08:34Z [Term] id: FYPO:0003333 name: inviable lemon-shaped cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a single cell is inviable, and grows in the form of a lemon prior to cell death. A lemon shape is defined mathematically as having a quadric surface in three dimensions obtained by rotating less than half of a circular arc about an axis passing through the endpoints of the arc." [http://mathworld.wolfram.com/Lemon.html, PomBase:mah] synonym: "inviable lemon-shaped cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable lemon-shaped cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable lemon-shaped vegetative cell" EXACT [PomBase:mah] is_a: FYPO:0002451 ! inviable vegetative cell with abnormal cell shape intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000224 ! lemon-shaped cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000224 ! lemon-shaped cell relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2014-04-29T14:10:35Z [Term] id: FYPO:0003334 name: normal protein localization to septin ring def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the septin ring is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to septin ring" EXACT [PomBase:mah] synonym: "normal protein localization to septin ring during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to septin ring during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001402 ! normal protein localization to cell cortex is_a: FYPO:0003184 ! normal protein localization to cytoskeleton during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902935 ! protein localization to septin ring intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902935 ! protein localization to septin ring relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-04-29T14:17:37Z [Term] id: FYPO:0003335 name: increased galactose-specific flocculation def: "A cell population phenotype that reflects increased occurrence of galactose-specific flocculation. Galactose-specific flocculation is the non-sexual aggregation of single cells, mediated by the binding of cell wall proteins on one cell to galactose residues on the other." [GO:0036349, PomBase:mah] synonym: "flocculating cells, galactose-specific " EXACT [PomBase:mah] synonym: "increased galactose-specific cell-cell adhesion" BROAD [PomBase:mah, PomBase:vw] is_a: FYPO:0000155 ! increased flocculation intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0036349 ! galactose-specific flocculation relationship: inheres_in GO:0036349 ! galactose-specific flocculation created_by: midori creation_date: 2014-04-29T14:33:45Z [Term] id: FYPO:0003336 name: increased duration of protein localization to actomyosin contractile ring def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which one or more proteins is localized to the actomyosin contractile ring for a longer time than normal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased duration of protein localisation to actomyosin contractile ring" EXACT [PomBase:mah] synonym: "increased duration of protein localization to actomyosin contractile ring during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased duration of protein localization to actomyosin contractile ring during vegetative growth" EXACT [PomBase:mah] synonym: "increased duration of protein localization to actomyosin contractile ring involved in mitotic cytokinesis" EXACT [GO:1904498] synonym: "increased duration of protein localization to contractile ring" EXACT [PomBase:mah] synonym: "increased duration of protein localization to cytokinetic contractile ring" EXACT [PomBase:vw] synonym: "increased duration of protein localization to mitotic contractile ring" EXACT [PomBase:vw] synonym: "prolonged protein localization to actomyosin contractile ring" EXACT [PomBase:vw] is_a: FYPO:0002527 ! increased duration of protein localization to cell division site intersection_of: PATO:0000498 ! increased duration intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1904498 ! protein localization to actomyosin contractile ring involved in mitotic cytokinesis relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1904498 ! protein localization to actomyosin contractile ring involved in mitotic cytokinesis created_by: midori creation_date: 2014-05-07T14:53:08Z [Term] id: FYPO:0003337 name: increased protein localization to septum def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the cell septum is increased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to septum" EXACT [PomBase:mah] synonym: "increased protein localization to barrier septum" EXACT [GO:0000935, PomBase:mah] synonym: "increased protein localization to cell septum" EXACT [PomBase:al] synonym: "increased protein localization to septum during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein localization to septum during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002718 ! abnormal protein localization to septum is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902432 ! protein localization to barrier septum relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902432 ! protein localization to barrier septum created_by: midori creation_date: 2014-05-07T14:55:56Z [Term] id: FYPO:0003338 name: abnormal actomyosin contractile ring morphology def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of the actomyosin contractile ring is abnormal." [PomBase:mah] synonym: "abnormal actomyosin contractile ring morphology during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal actomyosin contractile ring morphology during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal contractile ring morphology" EXACT [PomBase:mah] synonym: "abnormal cytokinetic contractile ring morphology" EXACT [PomBase:vw] synonym: "abnormal mitotic contractile ring morphology" EXACT [PomBase:vw] is_a: FYPO:0000350 ! abnormal actin cytoskeleton morphology during vegetative growth is_a: FYPO:0004736 ! abnormal actomyosin contractile ring intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005826 ! actomyosin contractile ring intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005826 ! actomyosin contractile ring relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-05-07T14:59:58Z [Term] id: FYPO:0003339 name: decreased rate of actomyosin contractile ring assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the rate, or speed, of contractile ring assembly is decreased. Contractile ring assembly is the part of cytokinesis in which the actomyosin contractile ring is formed of actin, myosin, and associated proteins." [PomBase:mah] synonym: "decreased rate of actomyosin contractile ring assembly during vegetative growth" EXACT [PomBase:mah] synonym: "decreased rate of contractile ring assembly" EXACT [PomBase:mah] synonym: "decreased rate of cytokinetic contractile ring assembly" EXACT [PomBase:vw] synonym: "decreased rate of mitotic contractile ring assembly" EXACT [PomBase:mah] synonym: "reduced rate of actomyosin contractile ring assembly" EXACT [PomBase:mah] is_a: FYPO:0000161 ! abnormal actomyosin contractile ring assembly is_a: PATO:0000911 ! decreased rate intersection_of: PATO:0000911 ! decreased rate intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000915 ! actomyosin contractile ring assembly relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000915 ! actomyosin contractile ring assembly created_by: midori creation_date: 2014-05-07T15:02:59Z [Term] id: FYPO:0003340 name: decreased re-entry into mitotic cell cycle during recovery from stationary phase def: "A cellular process phenotype in which the occurrence of re-entry into the mitotic cell cycle is decreased when the cell is in a population that has been in stationary phase and is then placed in conditions that allow recovery." [PMID:9199286, PomBase:mah] synonym: "decreased re-entry into mitotic cell cycle following growth to stationary phase" EXACT [PomBase:al] synonym: "reduced re-entry into mitotic cell cycle during recovery from stationary phase" EXACT [PomBase:mah] is_a: FYPO:0000145 ! regulation phenotype created_by: midori creation_date: 2014-05-07T15:40:33Z [Term] id: FYPO:0003341 name: multinucleate def: "A physical cellular phenotype in which a cell contains more than one nucleus." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "multinucleate cells" EXACT [PomBase:al] synonym: "multiple nuclei" EXACT [PomBase:al] is_a: FYPO:0000287 ! abnormal subcellular component is_a: PATO:0001908 ! multinucleate intersection_of: PATO:0001908 ! multinucleate intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) created_by: midori creation_date: 2014-05-07T15:45:12Z [Term] id: FYPO:0003342 name: elongated multinucleate cell def: "A cell phenotype in which a cell contains more than one nucleus and is elongated." [PomBase:mah] synonym: "long multinucleate cell" EXACT [PomBase:vw] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0003341 ! multinucleate relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0003341 ! multinucleate created_by: midori creation_date: 2014-05-07T15:47:45Z [Term] id: FYPO:0003343 name: elongated multinucleate multiseptate cell, septa between nuclei def: "A cell morphology phenotype in which a cell is longer than normal, has two or more nuclei and more than one septum, and the septa are located so as to form separate compartments with a single nucleus in each." [PomBase:mah, PomBase:vw] is_a: FYPO:0000133 ! elongated multinucleate vegetative cell is_a: FYPO:0000223 ! elongated multiseptate vegetative cell is_a: FYPO:0001252 ! multinucleate multiseptate vegetative cell created_by: midori creation_date: 2014-05-07T15:51:02Z [Term] id: FYPO:0003344 name: elongated multinucleate multiseptate cell, septa between nuclei, during stationary phase def: "A cell morphology phenotype observed when a cell population is in stationary phase in which a cell is longer than normal, has two or more nuclei and more than one septum, and the septa are located so as to form separate compartments with a single nucleus in each." [PomBase:mah, PomBase:vw] synonym: "elongated multinucleate multiseptate cell, septa between nuclei during vegetative growth" EXACT [PomBase:mah] synonym: "elongated multinucleate multiseptate cell, septa between nuclei, during stationary phase during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0003343 ! elongated multinucleate multiseptate cell, septa between nuclei created_by: midori creation_date: 2014-05-07T15:52:21Z [Term] id: FYPO:0003345 name: abolished cell cycle arrest in mitotic G1 phase in response to nitrogen starvation def: "A cellular process phenotype in which the occurrence of cell cycle arrest in response to nitrogen starvation does not occur; arrest normally occurs in G1 phase." [PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "abolished cell cycle arrest in mitotic G1 phase during cellular response to nitrogen starvation" EXACT [PomBase:mah] synonym: "abolished cell cycle arrest in mitotic G1 phase in response to nitrogen depletion" EXACT [PomBase:vw] synonym: "abolished cell cycle arrest in mitotic G1 phase in response to nitrogen deprivation" EXACT [PomBase:vw] synonym: "abolished mitotic cell cycle arrest in G1 phase in response to nitrogen starvation" EXACT [PomBase:mah] synonym: "abolished mitotic G1 arrest in response to nitrogen starvation" EXACT [PomBase:mah] synonym: "abolished nitrogen deprivation-induced G1 arrest" EXACT [PomBase:vw] synonym: "cell cycle arrest in mitotic G1 phase in response to nitrogen starvation abolished" EXACT [PomBase:mah] is_a: FYPO:0000445 ! cell cycle arrest in mitotic G1 phase is_a: FYPO:0000710 ! abnormal mitotic cell cycle arrest in response to nitrogen starvation is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0030996 ! mitotic cell cycle arrest in response to nitrogen starvation relationship: towards GO:0030996 ! mitotic cell cycle arrest in response to nitrogen starvation created_by: midori creation_date: 2014-05-07T15:56:55Z [Term] id: FYPO:0003346 name: abnormal meiotic recombination at silent mating-type cassette def: "A cellular process phenotype in which reciprocal meiotic recombination is abnormal at the silent mating-type cassettes. Meiotic recombination is a cellular process in which double strand breaks are formed and repaired through a double Holliday junction intermediate, resulting in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes." [GO:0007131, PomBase:mah] synonym: "abnormal meiotic DNA recombination at silent mating-type cassette" EXACT [PomBase:mah] synonym: "abnormal reciprocal meiotic recombination at silent mating-type cassette" EXACT [PomBase:mah] synonym: "abnormal recombination at silent mating-type cassette" BROAD [PomBase:mah] synonym: "DNA recombination defects, meiotic, at silent mating-type cassette" EXACT [PomBase:mah] is_a: FYPO:0000008 ! abnormal meiotic recombination intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0007131 ! reciprocal meiotic recombination intersection_of: occurs_at SO:0001984 ! silent_mating_type_cassette_array intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0007131 ! reciprocal meiotic recombination relationship: occurs_at SO:0001984 ! silent_mating_type_cassette_array relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-05-07T16:08:59Z [Term] id: FYPO:0003347 name: altered substrate specificity def: "A molecular function phenotype in which the substrate specificity of a catalytic activity differs from wild type." [PMID:23091597, PomBase:mah] synonym: "abnormal catalytic activity, altered substrate specificity" EXACT [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity created_by: midori creation_date: 2014-05-07T16:19:46Z [Term] id: FYPO:0003348 name: altered substrate specificity, glutathione synthetase to homoglutathione synthetase activity def: "A molecular function phenotype in which the substrate specificity of a gene product that executes glutathione synthetase activity in wild type is altered such that the gene product executes homoglutathione synthetase activity." [PMID:23091597, PomBase:mah] synonym: "abnormal catalytic activity, altered substrate specificity, glutathione synthetase to homoglutathione synthetase activity" EXACT [PomBase:mah] is_a: FYPO:0003347 ! altered substrate specificity created_by: midori creation_date: 2014-05-07T16:24:09Z [Term] id: FYPO:0003349 name: normal protein localization to mitotic spindle midzone during anaphase B def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the mitotic spindle midzone during anaphase B is normal (i.e. indistinguishable from wild type). The mitotic spindle midzone is the area in the center of the mitotic spindle where the spindle microtubules from opposite poles overlap. Anaphase B is the stage of mitosis in which the polar microtubules elongate and the two poles of the spindle move farther apart." [GO:0000092, GO:1990023, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to mitotic spindle midzone during anaphase B" EXACT [PomBase:mah] synonym: "normal protein localization to mitotic spindle midzone during anaphase B during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0004692 ! normal protein localization to mitotic spindle midzone intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0000092 ! mitotic anaphase B intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902967 ! protein localization to mitotic spindle midzone intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0000092 ! mitotic anaphase B relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902967 ! protein localization to mitotic spindle midzone relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-05-07T16:41:21Z [Term] id: FYPO:0003350 name: abolished protein localization to mitotic spindle midzone during anaphase B def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the mitotic spindle midzone during anaphase B does not occur. The mitotic spindle midzone is the area in the center of the mitotic spindle where the spindle microtubules from opposite poles overlap. Anaphase B is the stage of mitosis in which the polar microtubules elongate and the two poles of the spindle move farther apart." [GO:0000092, GO:1902967, GO:1990023, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "protein absent from mitotic spindle midzone during anaphase B" RELATED [PomBase:mah] synonym: "protein localisation to mitotic spindle midzone abolished during anaphase B" EXACT [PomBase:mah] synonym: "protein localization to mitotic spindle midzone abolished during anaphase B" EXACT [PomBase:mah] synonym: "protein localization to spindle midzone abolished during anaphase B during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0004412 ! abolished protein localization to mitotic spindle midzone during anaphase intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0000092 ! mitotic anaphase B intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1902967 ! protein localization to mitotic spindle midzone relationship: during GO:0000092 ! mitotic anaphase B relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1902967 ! protein localization to mitotic spindle midzone created_by: midori creation_date: 2014-05-07T16:44:01Z [Term] id: FYPO:0003351 name: increased duration of protein localization to kinetochore during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which one or more proteins is localized to the kinetochore of a chromosome for a longer time than normal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased duration of protein localisation to kinetochore during vegetative growth" EXACT [PomBase:mah] synonym: "increased duration of protein localization to kinetochore during mitotic cell cycle" RELATED [PomBase:mah] synonym: "prolonged protein localization to kinetochore during vegetative growth" EXACT [PomBase:vw] is_a: FYPO:0001268 ! abnormal protein localization to kinetochore during vegetative growth is_a: PATO:0000498 ! increased duration intersection_of: PATO:0000498 ! increased duration intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034501 ! protein localization to kinetochore relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034501 ! protein localization to kinetochore created_by: midori creation_date: 2014-05-07T16:46:42Z [Term] id: FYPO:0003352 name: decreased DNA double-strand break formation at mating-type locus def: "A DNA recombination phenotype observed in the vegetative growth phase of the life cycle in which DNA double-strand break formation occurs to a lower extent than normal during gene conversion at the mating-type locus." [PomBase:mah] synonym: "decreased DNA double-strand break formation at mating-type locus during gene conversion" EXACT [PomBase:mah] synonym: "decreased DNA double-strand break formation at mating-type locus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased DNA double-strand break formation at mating-type locus during vegetative growth" EXACT [PomBase:mah] synonym: "decreased DNA double-strand break formation during gene conversion at mating-type locus" EXACT [PomBase:mah] synonym: "decreased DSB formation at mat1" EXACT [PomBase:al] synonym: "decreased DSB formation at mating-type locus" EXACT [PomBase:mah] synonym: "decreased DSB formation proximal to mat1" EXACT [PomBase:al] synonym: "decreased gene conversion at mating-type locus, DNA double-strand break formation" EXACT [GO:0000728] synonym: "reduced DNA double-strand break formation at mating-type locus" EXACT [PomBase:mah] is_a: FYPO:0001345 ! abnormal DNA recombination during vegetative growth is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000728 ! gene conversion at mating-type locus, DNA double-strand break formation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_output FYPO:0000470 ! decreased mating type switching relationship: inheres_in GO:0000728 ! gene conversion at mating-type locus, DNA double-strand break formation created_by: midori creation_date: 2014-05-07T17:25:17Z [Term] id: FYPO:0003353 name: normal DNA double-strand break formation at mating-type locus def: "A DNA recombination phenotype observed in the vegetative growth phase of the life cycle in which DNA double-strand break formation is normal (i.e. indistinguishable from wild type) during gene conversion at the mating-type locus." [PomBase:mah] synonym: "normal DNA double-strand break formation at mating-type locus during gene conversion" EXACT [PomBase:mah] synonym: "normal DNA double-strand break formation at mating-type locus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal DNA double-strand break formation at mating-type locus during vegetative growth" EXACT [PomBase:mah] synonym: "normal DNA double-strand break formation during gene conversion at mating-type locus" EXACT [PomBase:mah] synonym: "normal DSB formation at mat1" EXACT [PomBase:al] synonym: "normal DSB formation at mating-type locus" EXACT [PomBase:mah] synonym: "normal DSB formation proximal to mat1" EXACT [PomBase:al] synonym: "normal gene conversion at mating-type locus, DNA double-strand break formation" EXACT [GO:0000728] is_a: FYPO:0000859 ! normal metabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000728 ! gene conversion at mating-type locus, DNA double-strand break formation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000728 ! gene conversion at mating-type locus, DNA double-strand break formation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-05-07T17:29:08Z [Term] id: FYPO:0003354 name: decreased galactose level in glycoprotein glycan def: "A phenotype in which the glycan moiety of a glycoprotein contains a lower amount of galactose residues than normal. In wild-type cells, glycoprotein glycans contain mannose and galactose residues in a 1:1.2 ratio, and the galactose residues are connected by alpha-1,2 linkages." [PMID:8782411, PomBase:mah] synonym: "decreased level of alpha 1,2-linked galactose residues in glycoprotein glycan" EXACT [PomBase:mah] synonym: "decreased protein glycan galactosylation" RELATED [PMID:8782411, PomBase:al] synonym: "reduced galactose level in glycoprotein glycan" EXACT [PomBase:mah] is_a: FYPO:0003290 ! abnormal glycoprotein glycan structure created_by: midori creation_date: 2014-05-12T14:28:42Z [Term] id: FYPO:0003355 name: growth auxotrophic for sulfur-containing amino acid def: "Auxotrophy in which a cell is unable to synthesize sulfur-containing amino acids, and therefore requires one or more sulfur-containing amino acids (e.g. cysteine or methionine) in the medium for vegetative cell growth." [PomBase:mah] synonym: "growth auxotrophic for sulfur-containing amino acid during mitotic cell cycle" RELATED [PomBase:mah] synonym: "growth auxotrophic for sulfur-containing amino acid during vegetative growth" EXACT [PomBase:mah] synonym: "growth auxotrophic for sulphur-containing amino acid" EXACT [PomBase:mah] synonym: "sulfur-containing amino acid auxotrophy" EXACT [PomBase:mah] is_a: FYPO:0000128 ! auxotrophy is_a: PATO:0000422 ! auxotrophic intersection_of: PATO:0000422 ! auxotrophic intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:26834 ! sulfur-containing amino acid relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:26834 ! sulfur-containing amino acid created_by: midori creation_date: 2014-05-12T15:24:39Z [Term] id: FYPO:0003356 name: sensitive to papuamide B during mating def: "A phenotype in which cells show increased sensitivity to papuamide B during mating. Cells stop growing (and may die) at a concentration of papuamide B that allows wild type cells to grow." [PMID:24514900, PomBase:mah] synonym: "sensitive to papuamide B during conjugation with cellular fusion" EXACT [GO:0000747] synonym: "sensitivity to chemicals interfering with lipids during mating" BROAD [PMID:24514900] is_a: FYPO:0002683 ! increased sensitivity to chemical intersection_of: FYPO:0002683 ! increased sensitivity to chemical intersection_of: during GO:0000747 ! conjugation with cellular fusion intersection_of: towards CHEBI:83265 ! papuamide B relationship: during GO:0000747 ! conjugation with cellular fusion relationship: towards CHEBI:83265 ! papuamide B created_by: midori creation_date: 2014-05-12T15:40:53Z [Term] id: FYPO:0003357 name: sensitive to filipin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to filipin. Cells stop growing (and may die) at a concentration of filipin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to filipin" EXACT [PomBase:mah] synonym: "sensitive to filipin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to filipin during vegetative growth" EXACT [PomBase:mah] synonym: "sensitivity to chemicals interfering with lipids" BROAD [PMID:24514900] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:83267 ! filipin III relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:83267 ! filipin III created_by: midori creation_date: 2014-05-12T15:46:17Z [Term] id: FYPO:0003358 name: sensitive to miconazole def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to miconazole. Cells stop growing (and may die) at a concentration of miconazole that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to miconazole" EXACT [PomBase:mah] synonym: "sensitive to miconazole during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to miconazole during vegetative growth" EXACT [PomBase:mah] synonym: "sensitivity to chemicals interfering with lipids" BROAD [PMID:24514900] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:6923 ! miconazole relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:6923 ! miconazole created_by: midori creation_date: 2014-05-12T15:47:17Z [Term] id: FYPO:0003359 name: sensitive to myriocin during vegetative growth def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to myriocin. Cells stop growing (and may die) at a concentration of myriocin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to myriocin during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to myriocin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitivity to chemicals interfering with lipids during vegetative growth" BROAD [PMID:24514900] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:582124 ! myriocin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:582124 ! myriocin created_by: midori creation_date: 2014-05-12T15:48:32Z [Term] id: FYPO:0003360 name: abolished superoxide dismutase activity def: "A molecular function phenotype in which superoxide dismutase activity is absent." [PomBase:mah] synonym: "superoxide dismutase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0003281 ! abnormal superoxide dismutase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0004784 ! superoxide dismutase activity relationship: towards GO:0004784 ! superoxide dismutase activity created_by: midori creation_date: 2014-05-29T15:25:07Z [Term] id: FYPO:0003361 name: normal superoxide dismutase activity def: "A molecular function phenotype in which the observed rate of superoxide dismutase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004784 ! superoxide dismutase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0004784 ! superoxide dismutase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-05-29T15:31:09Z [Term] id: FYPO:0003362 name: normal protein acetylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which protein acetylation is normal (i.e. indistinguishable from wild type). Protein acetylation is the addition of an acetyl group to a protein amino acid." [GO:0006473, PomBase:mah] synonym: "normal protein acetylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein acetylation during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein/peptide acetylation" EXACT [PomBase:mah] is_a: FYPO:0000549 ! normal protein modification during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006473 ! protein acetylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006473 ! protein acetylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-05-29T15:33:47Z [Term] id: FYPO:0003363 name: abolished cytogamy def: "A cellular process phenotype in which cytogamy does not occur. Cytogamy is the process that creates a single cell from two cells of complementary mating types." [GO:0000755, PomBase:mah] synonym: "conjugation without cellular fusion during mating" RELATED [PomBase:al] synonym: "cytogamy abolished" EXACT [PomBase:mah] is_a: FYPO:0000628 ! abnormal cellular process is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0000755 ! cytogamy relationship: towards GO:0000755 ! cytogamy created_by: midori creation_date: 2014-05-29T15:48:02Z [Term] id: FYPO:0003364 name: mislocalized nucleus during mating def: "A physical cellular phenotype in which a cell has a nucleus in an abnormal location during mating. The normal location of a single nucleus is at the midpoint of the long axis of the cell during vegetative growth, and during mating, the nucleus migrates towards the mating projection." [PMID:7791776, PomBase:al, PomBase:mah] synonym: "abnormal nucleus location during mating" EXACT [PomBase:mah] synonym: "abnormal nucleus position during mating" EXACT [PomBase:mah] synonym: "displaced nucleus during mating" EXACT [PomBase:vw] synonym: "mislocalised nucleus during mating" EXACT [PomBase:mah] synonym: "mislocalized nucleus during conjugation with cellular fusion" EXACT [GO:0000747] synonym: "misplaced nuclei during mating" EXACT [PomBase:vw] synonym: "misplaced nucleus during mating" EXACT [PomBase:vw] is_a: FYPO:0002069 ! mislocalized nucleus intersection_of: PATO:0000628 ! mislocalised intersection_of: exists_during GO:0000747 ! conjugation with cellular fusion intersection_of: inheres_in GO:0005634 ! nucleus relationship: exists_during GO:0000747 ! conjugation with cellular fusion relationship: inheres_in GO:0005634 ! nucleus created_by: midori creation_date: 2014-05-29T15:50:36Z [Term] id: FYPO:0003365 name: abnormal pyridoxine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of pyridoxine into the cell is abnormal." [PomBase:mah] synonym: "abnormal pyridoxine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal pyridoxine import during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal pyridoxine import into cell" EXACT [PomBase:al] synonym: "abnormal pyridoxine uptake" EXACT [PomBase:mah] is_a: FYPO:0001336 ! transport phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0001720 ! abnormal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1903075 ! pyridoxine import into cell intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1903075 ! pyridoxine import into cell relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-05-29T16:04:35Z [Term] id: FYPO:0003366 name: decreased pyridoxine import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of pyridoxine into the cell occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased pyridoxine import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased pyridoxine import during vegetative growth" EXACT [PomBase:mah] synonym: "decreased pyridoxine import into cell" EXACT [PomBase:al] synonym: "decreased pyridoxine uptake" EXACT [PomBase:mah] synonym: "reduced pyridoxine import" EXACT [PomBase:mah] is_a: FYPO:0003365 ! abnormal pyridoxine import is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903075 ! pyridoxine import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903075 ! pyridoxine import into cell created_by: midori creation_date: 2014-05-29T16:04:54Z [Term] id: FYPO:0003367 name: growth auxotrophic for pyridoxine def: "Auxotrophy in which a cell is unable to synthesize pyridoxine, and therefore requires pyridoxine in the medium for vegetative cell growth." [PomBase:mah] synonym: "growth auxotrophic for pyridoxine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "growth auxotrophic for pyridoxine during vegetative growth" EXACT [PomBase:mah] synonym: "pyridoxine auxotrophy" EXACT [PomBase:mah] is_a: FYPO:0000128 ! auxotrophy is_a: PATO:0000422 ! auxotrophic intersection_of: PATO:0000422 ! auxotrophic intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:16709 ! pyridoxine relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:16709 ! pyridoxine created_by: midori creation_date: 2014-05-29T16:07:39Z [Term] id: FYPO:0003368 name: resistance to sodium fluoride def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of sodium fluoride than normal." [PomBase:mah] synonym: "resistance to NaF" EXACT [PomBase:mah] synonym: "resistance to sodium fluoride during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to sodium fluoride during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to sodium fluoride" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:28741 ! sodium fluoride relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:28741 ! sodium fluoride created_by: midori creation_date: 2014-05-29T16:09:58Z [Term] id: FYPO:0003369 name: sensitive to sodium fluoride def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to sodium fluoride. Cells stop growing (and may die) at a concentration of sodium fluoride that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to sodium fluoride" EXACT [PomBase:mah] synonym: "sensitive to NaF" EXACT [PomBase:mah] synonym: "sensitive to sodium fluoride during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to sodium fluoride during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:28741 ! sodium fluoride relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:28741 ! sodium fluoride created_by: midori creation_date: 2014-05-29T16:12:14Z [Term] id: FYPO:0003370 name: normal growth on sodium fluoride def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing sodium fluoride." [PomBase:mah] synonym: "normal cell population growth in presence of sodium fluoride" EXACT [PomBase:mah] synonym: "normal cell population growth on sodium fluoride" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to sodium fluoride" RELATED [PomBase:al, PomBase:mah] synonym: "normal growth on NaF" EXACT [PomBase:mah] synonym: "normal vegetative cell population growth on sodium fluoride" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:28741 ! sodium fluoride relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:28741 ! sodium fluoride created_by: midori creation_date: 2014-05-29T16:14:04Z [Term] id: FYPO:0003371 name: abolished protein localization to actomyosin contractile ring, with protein mislocalized to cytoplasm def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the actomyosin contractile ring is abolished, and the protein is present in the cytoplasm instead." [PMID:18256290, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to actomyosin contractile ring, with protein mislocalized to cytoplasm" EXACT [PomBase:mah] synonym: "abolished protein localization to actomyosin contractile ring, with protein mislocalized to cytoplasm during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to actomyosin contractile ring, with protein mislocalized to cytoplasm, during vegetative growth" EXACT [PomBase:mah] synonym: "abolished protein localization to contractile ring, with protein mislocalized to cytoplasm" EXACT [PomBase:al] synonym: "abolished protein localization to cytokinetic contractile ring, with protein mislocalized to cytoplasm" EXACT [PomBase:vw] synonym: "abolished protein localization to mitotic contractile ring, with protein mislocalized to cytoplasm" EXACT [PomBase:vw] synonym: "protein localization to actomyosin contractile ring abolished, with protein mislocalized to cytoplasm" EXACT [PomBase:mah] is_a: FYPO:0002561 ! abolished protein localization to actomyosin contractile ring created_by: midori creation_date: 2014-05-29T16:16:00Z [Term] id: FYPO:0003372 name: RNA absent from cell during meiosis def: "A cell phenotype in which the amount of RNA measured in a cell is too low to detect during one or both meiotic nuclear divisions. Total RNA or a specific RNA may be affected." [PomBase:mah] synonym: "RNA absent from cell during meiotic nuclear division" EXACT [GO:0007126] synonym: "transcripts absent from cell during meiosis" EXACT [PomBase:vw] synonym: "undetectable cellular RNA level during meiosis" EXACT [PomBase:mah] is_a: FYPO:0001889 ! RNA absent from cell is_a: FYPO:0002959 ! decreased RNA level during meiosis intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0007126 ! meiotic nuclear division intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: during GO:0007126 ! meiotic nuclear division relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-05-29T16:34:44Z [Term] id: FYPO:0003373 name: abnormal cell cycle arrest in mitotic G2 phase def: "A cellular process phenotype in which progression through the mitotic cell cycle is arrested during G2 phase, under conditions where arrest is not a normal occurrence." [PomBase:mah] comment: Use this term if the cell cycle is abnormally arrested after completion of DNA replication (S phase) but before the G2/M transition. synonym: "abnormal cell cycle arrest in mitotic G2 phase during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal mitotic cell cycle arrest in G2 phase" EXACT [PomBase:mah] is_a: FYPO:0000446 ! cell cycle arrest in mitotic G2 phase is_a: FYPO:0001028 ! abnormal cell cycle arrest in mitotic interphase intersection_of: PATO:0001561 ! having extra processual parts intersection_of: during GO:0000085 ! mitotic G2 phase intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0071850 ! mitotic cell cycle arrest relationship: during GO:0000085 ! mitotic G2 phase relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0071850 ! mitotic cell cycle arrest created_by: midori creation_date: 2014-06-02T13:28:31Z [Term] id: FYPO:0003374 name: normal cellular coenzyme Q10 level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of coenzyme Q10 measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular coenzyme Q10 accumulation" RELATED [PomBase:mah] synonym: "normal cellular coenzyme Q10 level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular coenzyme Q10 level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:46245 ! coenzyme Q10 relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:46245 ! coenzyme Q10 created_by: midori creation_date: 2014-06-02T13:49:46Z [Term] id: FYPO:0003375 name: normal ubiquinone binding def: "A molecular function phenotype in which occurrence of ubiquinone binding by a gene product (usually a protein) in a mutant is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal coenzyme Q binding" EXACT [GO:0048039] is_a: FYPO:0000706 ! normal molecular function is_a: FYPO:0001092 ! binding phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0048039 ! ubiquinone binding intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0048039 ! ubiquinone binding relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-06-02T13:51:29Z [Term] id: FYPO:0003376 name: resistance to nitrogen starvation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which cells show decreased sensitivity to nitrogen starvation. Cells go on to grow and divide to a greater extent than wild type following nitrogen starvation." [PomBase:al, PomBase:mah] comment: Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation, but this term does not refer to such prolonged starvation. Use this term if you have assayed growth of cells exposed to nitrogen starvation in culture. If you have assayed the response to nitrogen starvation at the subcellular or molecular level, consider annotating to 'abnormal cellular response to nitrogen starvation' (FYPO:0000152). synonym: "resistance to nitrogen depletion" EXACT [PomBase:vw] synonym: "resistance to nitrogen deprivation" EXACT [PomBase:vw] synonym: "resistance to nitrogen starvation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to nitrogen starvation during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to nitrogen starvation" EXACT [PomBase:mah] is_a: FYPO:0000850 ! resistance to stress during vegetative growth created_by: midori creation_date: 2014-06-02T13:56:34Z [Term] id: FYPO:0003377 name: decreased RNA level during cellular response to nitrosative stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to nitrosative stress is lower than normal. Total RNA or a specific RNA may be affected. Nitrosative stress often results from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions." [GO:0071500, PMID:20204527, PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. NO levels can be increased experimentally by adding sodium nitroprusside to growth media. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased mRNA level during cellular response to nitrosative stress" NARROW [PomBase:mah] synonym: "decreased RNA accumulation during cellular response to nitrosative stress" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to nitrosative stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to nitrosative stress during vegetative growth" EXACT [PomBase:mah] synonym: "decreased transcript level during cellular response to nitrosative stress" EXACT [PomBase:vw] synonym: "reduced RNA level during cellular response to nitrosative stress" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0071500 ! cellular response to nitrosative stress intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0071500 ! cellular response to nitrosative stress relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-06-02T14:05:02Z [Term] id: FYPO:0003378 name: abolished meiosis I def: "A cellular process phenotype in which the first meiotic nuclear division, in which homologous chromosomes are normally paired and segregated from each other, does not occur." [GO:0007127, PomBase:mah] synonym: "abolished first meiotic nuclear division" EXACT [PomBase:al] synonym: "absent meiosis I" EXACT [PomBase:mah] synonym: "meiosis I abolished" EXACT [PomBase:mah] synonym: "meiosis I: absent" EXACT [PomBase:mah] is_a: FYPO:0000474 ! abolished meiosis intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0007127 ! meiosis I relationship: towards GO:0007127 ! meiosis I created_by: midori creation_date: 2014-06-02T14:29:46Z [Term] id: FYPO:0003379 name: abolished meiosis II def: "A cellular process phenotype in which the second meiotic nuclear division, in which two chromatids in each chromosome are normally separated, does not occur." [GO:0007135, PomBase:mah] synonym: "abolished second meiotic nuclear division" EXACT [PomBase:al] synonym: "absent meiosis II" EXACT [PomBase:mah] synonym: "meiosis II abolished" EXACT [PomBase:mah] synonym: "meiosis II: absent" EXACT [PomBase:mah] is_a: FYPO:0000474 ! abolished meiosis intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0007135 ! meiosis II relationship: towards GO:0007135 ! meiosis II created_by: midori creation_date: 2014-06-02T14:31:32Z [Term] id: FYPO:0003380 name: decreased meiosis I def: "A cellular process phenotype in which the occurrence of the first meiotic nuclear division, in which homologous chromosomes are normally paired and segregated from each other, is decreased." [PomBase:mah] synonym: "decreased first meiotic nuclear division" EXACT [PomBase:al] synonym: "meiosis I: decreased" EXACT [PomBase:mah] synonym: "reduced meiosis I" EXACT [PomBase:mah] is_a: FYPO:0000476 ! decreased meiosis intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0007127 ! meiosis I relationship: inheres_in GO:0007127 ! meiosis I created_by: midori creation_date: 2014-06-02T14:32:49Z [Term] id: FYPO:0003381 name: increased cellular glycerol level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of glycerol measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular glycerol level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular glycerol level during vegetative growth" EXACT [PomBase:mah] synonym: "increased glycerol accumulation" RELATED [PomBase:al] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:17754 ! glycerol relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:17754 ! glycerol created_by: midori creation_date: 2014-06-02T15:27:01Z [Term] id: FYPO:0003382 name: increased cellular acetate level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of acetate measured in a cell is higher than normal." [PomBase:mah] synonym: "increased acetate accumulation" RELATED [PomBase:al] synonym: "increased cellular acetate level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular acetate level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:30089 ! acetate relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:30089 ! acetate created_by: midori creation_date: 2014-06-02T15:28:29Z [Term] id: FYPO:0003383 name: resistance to tert-butyl hydroperoxide def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of tert-butyl hydroperoxide (TBHP or t-BOOH) than normal." [PomBase:mah] synonym: "resistance to 2-methyl-prop-2-yl-hydroperoxide" EXACT [CHEBI:64090] synonym: "resistance to t-BOOH" EXACT [PomBase:al, PomBase:mah] synonym: "resistance to TBHP" EXACT [CHEBI:64090, PomBase:al] synonym: "resistance to tert-butyl hydroperoxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to tert-butyl hydroperoxide during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to tert-butyl hydroperoxide" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:64090 ! tert-butyl hydroperoxide relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:64090 ! tert-butyl hydroperoxide created_by: midori creation_date: 2014-06-02T15:29:51Z [Term] id: FYPO:0003384 name: sensitive to chromium def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to chromium ions. Cells stop growing (and may die) at a concentration of chromium ions that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to chromium" EXACT [PomBase:mah] synonym: "sensitive to chromium during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to chromium during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to chromium ions" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:61310 ! chromium ion relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:61310 ! chromium ion created_by: midori creation_date: 2014-06-02T15:36:35Z [Term] id: FYPO:0003385 name: increased cellular cadmium level during cellular response to cadmium ion def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of cadmium ions measured in a cell is higher than normal during a cellular response to cadmium ion." [PomBase:mah] synonym: "increased cadmium accumulation during cellular response to cadmium" RELATED [PomBase:al] synonym: "increased cellular cadmium accumulation during cellular response to cadmium" RELATED [PomBase:mah] synonym: "increased cellular cadmium ion level during cellular response to cadmium" EXACT [PomBase:mah] synonym: "increased cellular cadmium level during cellular response to cadmium" EXACT [PomBase:mah] synonym: "increased cellular cadmium level during cellular response to cadmium during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular cadmium level during cellular response to cadmium during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0071276 ! cellular response to cadmium ion intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:63063 ! cadmium cation relationship: exists_during GO:0071276 ! cellular response to cadmium ion relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:63063 ! cadmium cation created_by: midori creation_date: 2014-06-02T15:40:07Z [Term] id: FYPO:0003386 name: increased superoxide dismutase activity def: "A molecular function phenotype in which the observed rate of superoxide dismutase activity is increased." [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0003281 ! abnormal superoxide dismutase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0004784 ! superoxide dismutase activity relationship: inheres_in GO:0004784 ! superoxide dismutase activity created_by: midori creation_date: 2014-06-02T15:42:15Z [Term] id: FYPO:0003387 name: decreased catalase activity def: "A molecular function phenotype in which the observed rate of catalase activity is decreased." [PomBase:mah] synonym: "reduced catalase activity" EXACT [PomBase:mah] is_a: FYPO:0000690 ! decreased oxidoreductase activity is_a: FYPO:0001104 ! abnormal catalase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004096 ! catalase activity relationship: inheres_in GO:0004096 ! catalase activity created_by: midori creation_date: 2014-06-02T15:42:47Z [Term] id: FYPO:0003388 name: decreased biotin import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of biotin into the cell occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased biotin import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased biotin import during vegetative growth" EXACT [PomBase:mah] synonym: "decreased biotin import into cell" EXACT [PomBase:al] synonym: "decreased biotin uptake" EXACT [PomBase:mah] synonym: "reduced biotin import" EXACT [PomBase:mah] is_a: FYPO:0001744 ! abnormal biotin import is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0044756 ! biotin import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0044756 ! biotin import into cell created_by: midori creation_date: 2014-06-02T15:44:42Z [Term] id: FYPO:0003389 name: viable elongated vegetative cell with swollen medial region def: "A cell morphology phenotype in which a vegetative cell is viable, is longer than normal, has a larger diameter than normal near the equator (but not at the ends), and has an overall volume greater than normal." [PMID:24554432, PomBase:mah, PomBase:vw] synonym: "medial bulge formation phenotype" EXACT [PMID:24554432] synonym: "viable elongated vegetative cell with swollen medial region during mitotic cell cycle" RELATED [PomBase:mah] synonym: "viable elongated vegetative cell with swollen medial region during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001492 ! viable elongated vegetative cell is_a: FYPO:0002402 ! viable swollen vegetative cell with abnormal cell shape is_a: FYPO:0002479 ! viable swollen elongated vegetative cell created_by: midori creation_date: 2014-06-02T15:49:47Z [Term] id: FYPO:0003390 name: protein mislocalized to medial cortex during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a protein that is not normally found at the medial cortex is observed there." [PomBase:mah] comment: Note that this term can be used to annotate any case where a protein is found in the medial cortex in a mutant, but not in wild type. In some cases, there may be enough additional information to annotate to 'abnormal protein localization' (FYPO:0000443) or one of its descendants. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "ectopic protein localization to medial cortex during vegetative growth" EXACT [PomBase:vw] synonym: "protein mislocalised to medial cortex during vegetative growth" EXACT [PomBase:mah] synonym: "protein mislocalized to medial cortex during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000782 ! mislocalized protein during vegetative growth intersection_of: PATO:0000628 ! mislocalised intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CHEBI:36080 ! protein intersection_of: towards GO:0031097 ! medial cortex relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CHEBI:36080 ! protein relationship: towards GO:0031097 ! medial cortex created_by: midori creation_date: 2014-06-02T16:00:13Z [Term] id: FYPO:0003391 name: abnormal ubiquinone binding def: "A molecular function phenotype in which occurrence of ubiquinone binding by a gene product (usually a protein) in a mutant is abnormal. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "abnormal coenzyme Q binding" EXACT [GO:0048039] is_a: FYPO:0000707 ! abnormal molecular function is_a: FYPO:0001092 ! binding phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0048039 ! ubiquinone binding intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0048039 ! ubiquinone binding relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-06-03T11:43:10Z [Term] id: FYPO:0003392 name: decreased ubiquinone binding def: "A molecular function phenotype in which occurrence of ubiquinone binding by a gene product (usually a protein) in a mutant is decreased. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "decreased coenzyme Q binding" EXACT [GO:0048039] synonym: "reduced ubiquinone binding" EXACT [PomBase:mah] is_a: FYPO:0003391 ! abnormal ubiquinone binding is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0048039 ! ubiquinone binding relationship: inheres_in GO:0048039 ! ubiquinone binding created_by: midori creation_date: 2014-06-03T11:43:17Z [Term] id: FYPO:0003393 name: abnormal respiratory electron transport def: "A metabolism phenotype observed in the vegetative growth phase of the life cycle in which electron transport involved in cellular respiration is abnormal." [PomBase:mah] synonym: "abnormal respiratory electron transport chain" EXACT [GO:0022904] synonym: "abnormal respiratory electron transport during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal respiratory electron transport process during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000078 ! abnormal cellular respiration intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0022904 ! respiratory electron transport chain intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0022904 ! respiratory electron transport chain relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-06-03T11:54:26Z [Term] id: FYPO:0003394 name: decreased mitochondrial electron transport, NADH to ubiquinone def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of mitochondrial electron transport from NADH to ubiquinone is decreased." [GO:0006120, PomBase:mah] synonym: "decreased mitochondrial electron transport, NADH to ubiquinone, during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased mitochondrial electron transport, NADH to ubiquinone, during vegetative growth" EXACT [PomBase:mah] synonym: "decreased NADH cytochrome c oxidoreductase" RELATED [PMID:8668131] synonym: "decreased NADH dehydrogenase (quinone) activity and ubiquinol-cytochrome-c reductase activity" RELATED [PMID:8668131, PomBase:vw] synonym: "reduced mitochondrial electron transport, NADH to ubiquinone" EXACT [PomBase:mah] is_a: FYPO:0001348 ! cellular metabolism phenotype during vegetative growth is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006120 ! mitochondrial electron transport, NADH to ubiquinone relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006120 ! mitochondrial electron transport, NADH to ubiquinone created_by: midori creation_date: 2014-06-03T11:57:25Z [Term] id: FYPO:0003395 name: abolished mitochondrial electron transport, succinate to ubiquinone def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of mitochondrial electron transport from succinate to ubiquinone, mediated by complex II, does not occur." [GO:0006121, PomBase:mah] synonym: "abolished mitochondrial electron transport, succinate to ubiquinone, during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished mitochondrial electron transport, succinate to ubiquinone, during vegetative growth" EXACT [PomBase:mah] synonym: "abolished succinate cytochrome c oxidoreductase" RELATED [PMID:8668131] synonym: "abolished succinate dehydrogenase (ubiquinone) activity and ubiquinol-cytochrome-c reductase activity" RELATED [PMID:8668131, PomBase:vw] synonym: "mitochondrial electron transport, succinate to ubiquinone, abolished" EXACT [PomBase:mah] is_a: FYPO:0001348 ! cellular metabolism phenotype during vegetative growth is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0006121 ! mitochondrial electron transport, succinate to ubiquinone relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0006121 ! mitochondrial electron transport, succinate to ubiquinone created_by: midori creation_date: 2014-06-03T12:02:05Z [Term] id: FYPO:0003396 name: resistance to ricinoleic acid def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of ricinoleic acid than normal." [PomBase:mah] synonym: "resistance to RA" BROAD [PomBase:al] synonym: "resistance to ricinoleic acid during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to ricinoleic acid during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to ricinoleic acid" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:28592 ! ricinoleic acid relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:28592 ! ricinoleic acid created_by: midori creation_date: 2014-06-03T12:29:08Z [Term] id: FYPO:0003397 name: decreased 35S rRNA precursor level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of the 35S rRNA primary transcript measured in a cell is lower than normal." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "decreased 35S rRNA precursor accumulation" RELATED [PomBase:mah] synonym: "decreased 35S rRNA precursor level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased 35S rRNA precursor level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased 35S rRNA precursor transcript level" EXACT [PomBase:vw] synonym: "decreased 35S rRNA primary transcript level" EXACT [PomBase:mah, SO:0000325] synonym: "reduced 35S rRNA precursor level" EXACT [PomBase:mah] is_a: FYPO:0003601 ! decreased rRNA precursor level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards SO:0000325 ! rRNA_large_subunit_primary_transcript relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards SO:0000325 ! rRNA_large_subunit_primary_transcript created_by: midori creation_date: 2014-06-03T13:28:48Z [Term] id: FYPO:0003398 name: decreased 32S rRNA precursor level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of any 32S rRNA precursor measured in a cell is lower than normal." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "decreased 32S rRNA precursor accumulation" RELATED [PomBase:mah] synonym: "decreased 32S rRNA precursor level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased 32S rRNA precursor level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased 32S rRNA precursor transcript level" EXACT [PomBase:vw] synonym: "reduced 32S rRNA precursor level" EXACT [PomBase:mah] is_a: FYPO:0003601 ! decreased rRNA precursor level created_by: midori creation_date: 2014-06-03T13:29:06Z [Term] id: FYPO:0003399 name: normal 27S rRNA precursor level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of 27S ribosomal RNA precursor measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal 27S rRNA precursor accumulation" RELATED [PomBase:mah] synonym: "normal 27S rRNA precursor level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal 27S rRNA precursor level during vegetative growth" EXACT [PomBase:mah] synonym: "normal 27S rRNA precursor transcript level" EXACT [PomBase:vw] is_a: FYPO:0001317 ! normal RNA level during vegetative growth created_by: midori creation_date: 2014-06-03T13:34:04Z [Term] id: FYPO:0003400 name: normal 20S rRNA precursor level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of 20S ribosomal RNA precursor measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal 20S rRNA precursor accumulation" RELATED [PomBase:mah] synonym: "normal 20S rRNA precursor level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal 20S rRNA precursor level during vegetative growth" EXACT [PomBase:mah] synonym: "normal 20S rRNA precursor transcript level" EXACT [PomBase:vw] is_a: FYPO:0001317 ! normal RNA level during vegetative growth created_by: midori creation_date: 2014-06-03T13:36:16Z [Term] id: FYPO:0003401 name: elongated cell during cellular response to osmotic stress def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is elongated during a cellular response to osmotic stress." [PomBase:mah] synonym: "elongated cell during cellular response to osmotic stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "elongated cell during cellular response to osmotic stress during vegetative growth" EXACT [PomBase:mah] synonym: "elongated in response to osmotic stress" EXACT [PomBase:al] is_a: FYPO:0001122 ! elongated vegetative cell intersection_of: FYPO:0000017 ! elongated cell intersection_of: exists_during GO:0071470 ! cellular response to osmotic stress intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: exists_during GO:0071470 ! cellular response to osmotic stress relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) created_by: midori creation_date: 2014-06-03T14:18:47Z [Term] id: FYPO:0003402 name: abnormal mitotic cell cycle regulation during cellular response to osmotic stress def: "A cellular response phenotype observed in the vegetative growth phase of the life cycle in which the regulation of the mitotic cell cycle in response to osmotic stress is abnormal." [PomBase:mah] synonym: "abnormal cell cycle regulation during cellular response to osmotic stress" EXACT [PomBase:mah] synonym: "abnormal mitotic cell cycle regulation in response to osmotic stress" EXACT [PomBase:mah] is_a: FYPO:0000148 ! abnormal regulation of mitotic cell cycle is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0071470 ! cellular response to osmotic stress intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0007346 ! regulation of mitotic cell cycle intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0071470 ! cellular response to osmotic stress relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0007346 ! regulation of mitotic cell cycle relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-06-03T14:19:45Z [Term] id: FYPO:0003403 name: abnormal glyoxalase III activity def: "A molecular function phenotype in which the observed rate of glyoxalase III activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0019172 ! glyoxalase III activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0019172 ! glyoxalase III activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-06-03T14:24:07Z [Term] id: FYPO:0003404 name: abolished glyoxalase III activity def: "A molecular function phenotype in which glyoxalase III activity is absent." [PomBase:mah] synonym: "glyoxalase III activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0003403 ! abnormal glyoxalase III activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0019172 ! glyoxalase III activity relationship: towards GO:0019172 ! glyoxalase III activity created_by: midori creation_date: 2014-06-03T14:24:17Z [Term] id: FYPO:0003405 name: decreased glyoxalase III activity def: "A molecular function phenotype in which the observed rate of glyoxalase III activity is decreased." [PomBase:mah] synonym: "reduced glyoxalase III activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0003403 ! abnormal glyoxalase III activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0019172 ! glyoxalase III activity relationship: inheres_in GO:0019172 ! glyoxalase III activity created_by: midori creation_date: 2014-06-03T14:24:36Z [Term] id: FYPO:0003406 name: resistance to methylglyoxal def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of methylglyoxal than normal." [PomBase:mah] synonym: "resistance to methylglyoxal during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to methylglyoxal during vegetative growth" EXACT [PomBase:mah] synonym: "resistance to MG" BROAD [PomBase:al] synonym: "resistant to methylglyoxal" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:17158 ! methylglyoxal relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:17158 ! methylglyoxal created_by: midori creation_date: 2014-06-03T14:40:47Z [Term] id: FYPO:0003407 name: resistance to glyoxal def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of glyoxal than normal." [PomBase:mah] synonym: "resistance to glyoxal during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to glyoxal during vegetative growth" EXACT [PomBase:mah] synonym: "resistance to GO" BROAD [PomBase:al] synonym: "resistant to glyoxal" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:34779 ! glyoxal relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:34779 ! glyoxal created_by: midori creation_date: 2014-06-03T14:41:33Z [Term] id: FYPO:0003408 name: sensitive to methylglyoxal def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to methylglyoxal. Cells stop growing (and may die) at a concentration of methylglyoxal that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to methylglyoxal" EXACT [PomBase:mah] synonym: "sensitive to methylglyoxal during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to methylglyoxal during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to MG" BROAD [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:17158 ! methylglyoxal relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:17158 ! methylglyoxal created_by: midori creation_date: 2014-06-03T14:42:12Z [Term] id: FYPO:0003409 name: abnormal CENP-A containing nucleosome assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the formation of nucleosomes containing the histone H3 variant CenH3 (also called CENP-A; Cnp1 in S. pombe) is abnormal. CENP-A-containing nucleosomes are normally assembled into chromatin around centromeres, encompassing the central core and centromeric inner repeat regions." [GO:0034080, PMID:24710126, PomBase:mah, PomBase:vw] synonym: "abnormal CenH3-containing nucleosome assembly" RELATED [GO:0034080] synonym: "abnormal CENP-A containing nucleosome assembly at centromere" EXACT [GO:0034080] synonym: "abnormal CENP-A containing nucleosome assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal CENP-A containing nucleosome assembly during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal CENP-A deposition" RELATED [GO:0034080] synonym: "abnormal CENP-A loading" RELATED [GO:0034080] synonym: "abnormal centromere-specific histone exchange" EXACT [GO:0034080] synonym: "abnormal centromere-specific nucleosome assembly" EXACT [GO:0034080] synonym: "abnormal centromeric DNA replication-independent nucleosome assembly" EXACT [GO:0034080] synonym: "abnormal DNA replication-independent nucleosome assembly at centromere" EXACT [GO:0034080] is_a: FYPO:0001354 ! abnormal cellular component assembly during vegetative growth is_a: FYPO:0004308 ! abnormal CENP-A containing chromatin organization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0034080 ! CENP-A containing nucleosome assembly intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0034080 ! CENP-A containing nucleosome assembly relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-06-03T15:37:34Z [Term] id: FYPO:0003410 name: increased spatial extent of CENP-A containing nucleosome assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which nucleosomes containing the histone H3 variant CenH3 (also called CENP-A; Cnp1 in S. pombe) are assembled over a larger portion of the chromosome than normal. CENP-A-containing nucleosomes are normally assembled into chromatin around centromeres, encompassing the central core and centromeric inner repeat regions." [GO:0034080, PMID:24710126, PomBase:mah, PomBase:vw] synonym: "CENP-A containing nucleosome spreading" RELATED [PomBase:vw] synonym: "increased extent of CENP-A containing nucleosome" RELATED [PomBase:vw] synonym: "increased spatial extent of CenH3-containing nucleosome assembly at centromere" RELATED [GO:0034080] synonym: "increased spatial extent of CENP-A containing nucleosome assembly at centromere" EXACT [GO:0034080] synonym: "increased spatial extent of CENP-A containing nucleosome assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased spatial extent of CENP-A containing nucleosome assembly during vegetative growth" EXACT [PomBase:mah] synonym: "increased spatial extent of CENP-A deposition" RELATED [GO:0034080] synonym: "increased spatial extent of CENP-A loading" RELATED [GO:0034080] synonym: "increased spatial extent of centromere-specific histone exchange" EXACT [GO:0034080] synonym: "increased spatial extent of centromere-specific nucleosome assembly" EXACT [GO:0034080] synonym: "increased spatial extent of centromeric DNA replication-independent nucleosome assembly" EXACT [GO:0034080] synonym: "increased spatial extent of DNA replication-independent nucleosome assembly at centromere" EXACT [GO:0034080] is_a: FYPO:0003409 ! abnormal CENP-A containing nucleosome assembly created_by: midori creation_date: 2014-06-03T15:41:14Z [Term] id: FYPO:0003411 name: decreased chromatin silencing at centromere inner repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of chromatin silencing at centromere inner repeat regions is decreased." [PomBase:mah] synonym: "decreased chromatin silencing at centromere imr" EXACT [PomBase:mah] synonym: "decreased chromatin silencing at centromere inner repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased chromatin silencing at centromere inner repeat during vegetative growth" EXACT [PomBase:mah] synonym: "decreased chromatin silencing at centromeric inner repeat region" EXACT [PomBase:mah] synonym: "decreased heterochromatin silencing at centromere inner repeat" EXACT [PomBase:mah] synonym: "reduced chromatin silencing at centromere inner repeat" EXACT [PomBase:mah] is_a: FYPO:0002834 ! decreased chromatin silencing at centromere intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0030702 ! chromatin silencing at centromere intersection_of: occurs_at SO:0001798 ! regional_centromere_inner_repeat_region relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0030702 ! chromatin silencing at centromere relationship: occurs_at SO:0001798 ! regional_centromere_inner_repeat_region created_by: midori creation_date: 2014-06-03T15:53:45Z [Term] id: FYPO:0003412 name: decreased chromatin silencing at centromere outer repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of chromatin silencing at centromere outer repeat regions is decreased." [PomBase:mah] synonym: "decreased chromatin silencing at centromere otr" EXACT [PomBase:mah] synonym: "decreased chromatin silencing at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased chromatin silencing at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] synonym: "decreased chromatin silencing at centromere outer repeat region" EXACT [PomBase:mah] synonym: "decreased chromatin silencing at centromeric outer repeat region" EXACT [PomBase:mah] synonym: "decreased chromatin silencing at pericentric region" RELATED [PomBase:mah] synonym: "decreased chromatin silencing at pericentromeric region" RELATED [PomBase:mah] synonym: "decreased heterochromatin silencing at centromere outer repeat region" EXACT [PomBase:mah] synonym: "reduced chromatin silencing at centromere outer repeat" EXACT [PomBase:mah] is_a: FYPO:0002834 ! decreased chromatin silencing at centromere intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990141 ! chromatin silencing at centromere outer repeat region relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990141 ! chromatin silencing at centromere outer repeat region created_by: midori creation_date: 2014-06-03T15:54:43Z [Term] id: FYPO:0003413 name: inviable branched, elongated, multiseptate vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is inviable, forms one or more branches near a septum, is elongated, and has more than one septum." [PMID:18256290, PomBase:mah] synonym: "inviable branched, elongated, multiseptate cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable branched, elongated, multiseptate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable branched, long, multiseptate cell" EXACT [PomBase:vw] is_a: FYPO:0000134 ! branched, elongated, multiseptate cell is_a: FYPO:0001494 ! inviable elongated multiseptate vegetative cell is_a: FYPO:0002462 ! inviable branched, elongated vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000015 ! branched vegetative cell intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000118 ! multiseptate vegetative cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000015 ! branched vegetative cell relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000118 ! multiseptate vegetative cell relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2014-06-05T16:14:54Z [Term] id: FYPO:0003414 name: normal protein localization to septum def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the cell septum is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to septum" EXACT [PomBase:mah] synonym: "normal protein localization to barrier septum" EXACT [GO:0000935, PomBase:mah] synonym: "normal protein localization to cell septum" EXACT [PomBase:al] synonym: "normal protein localization to septum during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to septum during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000644 ! normal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902432 ! protein localization to barrier septum intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902432 ! protein localization to barrier septum relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-06-05T16:22:12Z [Term] id: FYPO:0003415 name: increased histone H4 acetylation at centromere central core def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone H4 acetylation occurs to a greater extent than normal at the central core of centromeric regions." [PomBase:mah] synonym: "abnormal histone H4 acetylation at centromeric central core" EXACT [PomBase:mah] synonym: "increased histone H4 acetylation at centromere central core during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H4 acetylation at centromere central core during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002365 ! increased histone H4 acetylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0043967 ! histone H4 acetylation intersection_of: occurs_at SO:0001796 ! regional_centromere_central_core relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0043967 ! histone H4 acetylation relationship: occurs_at SO:0001796 ! regional_centromere_central_core created_by: midori creation_date: 2014-06-05T16:37:03Z [Term] id: FYPO:0003416 name: cytoplasmic vesicles present in greater numbers def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells contain more cytoplasmic membrane-bounded vesicles than normal." [PomBase:mah] comment: This term can be used when the vesicles observed may be endocytic or exocytic vesicles. synonym: "additional cytoplasmic vesicles present during vegetative growth" EXACT [PomBase:mah] synonym: "cytoplasmic vesicles present in greater numbers during mitotic cell cycle" RELATED [PomBase:mah] synonym: "cytoplasmic vesicles present in greater numbers during vegetative growth" EXACT [PomBase:mah] synonym: "extra cytoplasmic vesicles during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: PATO:0002002 ! has extra parts of type intersection_of: PATO:0002002 ! has extra parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0016023 ! cytoplasmic membrane-bounded vesicle relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0016023 ! cytoplasmic membrane-bounded vesicle created_by: midori creation_date: 2014-06-11T11:58:49Z [Term] id: FYPO:0003417 name: increased microtubule dwell time at cell tip def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which microtubule plus ends remain in contact with the cell cortex at cell tips for a longer time than normal." [PMID:24530531, PomBase:mah] synonym: "increased microtubule plus end dwell time at cell tip" EXACT [PMID:24530531] is_a: FYPO:0001350 ! abnormal microtubule cytoskeleton organization during vegetative growth created_by: midori creation_date: 2014-06-11T12:05:54Z [Term] id: FYPO:0003418 name: abolished malate dehydrogenase (decarboxylating) (NAD+) activity def: "A molecular function phenotype in which malate dehydrogenase (decarboxylating) (NAD+) activity is absent." [PomBase:mah] synonym: "abolished 'malic' enzyme activity" RELATED [GO:0004471] synonym: "abolished (S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating) activity" EXACT [GO:0004471] synonym: "abolished NAD-linked malic enzyme activity" RELATED [GO:0004471] synonym: "abolished NAD-malic enzyme activity" BROAD [GO:0004471] synonym: "abolished NAD-specific malic enzyme activity" RELATED [GO:0004471] synonym: "decreased malate dehydrogenase (oxaloacetate-decarboxylating) activity" EXACT [GO:0004471] synonym: "malate dehydrogenase (decarboxylating) (NAD+) activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0002621 ! abnormal malate dehydrogenase (decarboxylating) (NAD+) activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0004471 ! malate dehydrogenase (decarboxylating) (NAD+) activity relationship: towards GO:0004471 ! malate dehydrogenase (decarboxylating) (NAD+) activity created_by: midori creation_date: 2014-06-11T12:17:05Z [Term] id: FYPO:0003419 name: increased malate dehydrogenase (decarboxylating) (NAD+) activity def: "A molecular function phenotype in which the observed rate of malate dehydrogenase (decarboxylating) (NAD+) activity is increased." [PomBase:mah] synonym: "decreased malate dehydrogenase (oxaloacetate-decarboxylating) activity" EXACT [GO:0004471] synonym: "increased 'malic' enzyme activity" RELATED [GO:0004471] synonym: "increased (S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating) activity" EXACT [GO:0004471] synonym: "increased NAD-linked malic enzyme activity" RELATED [GO:0004471] synonym: "increased NAD-malic enzyme activity" BROAD [GO:0004471] synonym: "increased NAD-specific malic enzyme activity" RELATED [GO:0004471] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0002621 ! abnormal malate dehydrogenase (decarboxylating) (NAD+) activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0004471 ! malate dehydrogenase (decarboxylating) (NAD+) activity relationship: inheres_in GO:0004471 ! malate dehydrogenase (decarboxylating) (NAD+) activity created_by: midori creation_date: 2014-06-11T12:18:56Z [Term] id: FYPO:0003420 name: increased cellular glutathione level during cellular response to cadmium ion def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of glutathione (GSH) measured in a cell is higher than normal during a cellular response to cadmium." [PomBase:mah] synonym: "increased cellular glutathione level during cellular response to cadmium" EXACT [PomBase:mah] synonym: "increased cellular glutathione level during cellular response to cadmium during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular glutathione level during cellular response to cadmium during vegetative growth" EXACT [PomBase:mah] synonym: "increased cellular GSH level during cellular response to cadmium" EXACT [CHEBI:16856, PomBase:al] synonym: "increased cellular L-gamma-glutamyl-L-cysteinylglycine level during cellular response to cadmium" EXACT [CHEBI:16856] synonym: "increased cellular reduced glutathione level during cellular response to cadmium" EXACT [CHEBI:16856, PomBase:al] synonym: "increased glutathione accumulation during cellular response to cadmium" RELATED [PomBase:mah] is_a: FYPO:0001521 ! increased cellular glutathione level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0071276 ! cellular response to cadmium ion intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:16856 ! glutathione relationship: exists_during GO:0071276 ! cellular response to cadmium ion relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:16856 ! glutathione created_by: midori creation_date: 2014-06-11T13:03:52Z [Term] id: FYPO:0003421 name: decreased cellular nitric oxide level during cellular response to cadmium ion def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of nitric oxide measured in a cell is lower than normal during a cellular response to cadmium." [PomBase:mah] synonym: "decreased cellular nitric oxide level during cellular response to cadmium" EXACT [PomBase:mah] synonym: "decreased cellular nitric oxide level during cellular response to cadmium during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular nitric oxide level during cellular response to cadmium during vegetative growth" EXACT [PomBase:mah] synonym: "decreased cellular NO level during cellular response to cadmium" EXACT [CHEBI:16480] synonym: "decreased nitric oxide accumulation during cellular response to cadmium" RELATED [PomBase:mah] synonym: "reduced cellular nitric oxide level during cellular response to cadmium" EXACT [PomBase:mah] is_a: FYPO:0003127 ! decreased cellular nitric oxide level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0071276 ! cellular response to cadmium ion intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:16480 ! nitric oxide relationship: exists_during GO:0071276 ! cellular response to cadmium ion relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:16480 ! nitric oxide created_by: midori creation_date: 2014-06-11T13:06:05Z [Term] id: FYPO:0003422 name: inviable after spore germination, multiple cell divisions, elongated multiseptate tapered cell def: "A phenotype in which a spore germinates to produce a cell that is elongated and tapered, i.e. tapers at one end to a diameter smaller than the other, contains more than one septum, and undergoes two or more rounds of cell division and then dies." [PomBase:al, PomBase:mah] synonym: "essential; germinating spore, multiple cell divisions, elongated multiseptate tapered cell" RELATED [PomBase:mah] synonym: "inviable after spore germination, multiple cell divisions, elongated multiseptate bottle-shaped cell" EXACT [PomBase:vw] synonym: "inviable after spore germination, multiple cell divisions, elongated multiseptate bottle/skittle cell" EXACT [PomBase:mah] synonym: "inviable after spore germination, multiple cell divisions, elongated multiseptate skittle-shaped cell" EXACT [PomBase:mah] synonym: "inviable following spore germination, multiple cell divisions, elongated multiseptate tapered cell" EXACT [PomBase:mah] synonym: "inviable germinated spore, multiple cell divisions, elongated multiseptate tapered cell" EXACT [PomBase:mah] is_a: FYPO:0001494 ! inviable elongated multiseptate vegetative cell is_a: FYPO:0002450 ! inviable after spore germination, multiple cell divisions, septated cell with abnormal morphology is_a: FYPO:0002452 ! inviable septated vegetative cell with abnormal cell morphology is_a: FYPO:0002733 ! inviable after spore germination, multiple cell divisions, elongated tapered cell created_by: midori creation_date: 2014-06-11T13:17:31Z [Term] id: FYPO:0003423 name: decreased mitochondrial RNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of mitochondrial RNA measured in a cell is lower than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased mitochondrial RNA accumulation" RELATED [PomBase:mah] synonym: "decreased mitochondrial RNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased mitochondrial RNA level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased mitochondrial transcript level" EXACT [PomBase:vw] synonym: "decreased RNA level in mitochondrion" EXACT [PomBase:mah] synonym: "reduced mitochondrial RNA level" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005739 ! mitochondrion intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005739 ! mitochondrion relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-06-11T13:44:20Z [Term] id: FYPO:0003424 name: increased mitochondrial RNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of mitochondrial RNA measured in a cell is greater than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased mitochondrial RNA accumulation" RELATED [PomBase:mah] synonym: "increased mitochondrial RNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased mitochondrial RNA level during vegetative growth" EXACT [PomBase:mah] synonym: "increased mitochondrial transcript level" EXACT [PomBase:vw] synonym: "increased RNA level in mitochondrion" EXACT [PomBase:mah] is_a: FYPO:0000825 ! increased RNA level during vegetative growth is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005739 ! mitochondrion intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005739 ! mitochondrion relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-06-11T13:58:16Z [Term] id: FYPO:0003425 name: abolished protein binding during cellular response to rapamycin def: "A molecular function phenotype in which the binding of one protein to another does not occur during a cellular response to rapamycin. The relevant proteins may include the one encoded by the mutated gene, or may both be encoded by different genes." [PomBase:mah] comment: This term can be used for any protein-protein interaction that is affected by a mutation, whether or not the mutated gene product is one of the interacting proteins. We recommend noting which proteins were used in the assay when annotating to this term. synonym: "abolished protein-protein interaction during cellular response to rapamycin" EXACT [PomBase:mah] synonym: "protein binding abolished during cellular response to rapamycin" EXACT [PomBase:mah] is_a: FYPO:0000705 ! abolished protein binding intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072752 ! cellular response to rapamycin intersection_of: towards GO:0005515 ! protein binding relationship: during GO:0072752 ! cellular response to rapamycin relationship: towards GO:0005515 ! protein binding created_by: midori creation_date: 2014-06-11T14:14:35Z [Term] id: FYPO:0003426 name: decreased RNA level during cellular response to pheromone def: "A cell phenotype in which the amount of RNA measured in a cell during a cellular response to a pheromone is lower than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased RNA accumulation during cellular response to pheromone" RELATED [PomBase:mah] synonym: "decreased transcript level during cellular response to pheromone" EXACT [PomBase:vw] synonym: "reduced RNA level during cellular response to pheromone" EXACT [PomBase:mah] is_a: FYPO:0000826 ! decreased RNA level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0071444 ! cellular response to pheromone intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0071444 ! cellular response to pheromone relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-06-11T14:16:53Z [Term] id: FYPO:0003427 name: decreased queuosine level in tRNA def: "A phenotype in which one or more transfer RNA (tRNA) molecules contains fewer queuosine residues than normal." [PMID:24911101, PomBase:mah] synonym: "reduced queuosine content of tRNA" EXACT [PomBase:vw] synonym: "reduced queuosine level in tRNA" EXACT [PomBase:mah] is_a: FYPO:0001985 ! abnormal phenotype created_by: midori creation_date: 2014-06-11T14:25:29Z [Term] id: FYPO:0003428 name: growth auxotrophic for arginine and cysteine def: "Auxotrophy in which a cell is unable to synthesize arginine or cysteine, and therefore requires arginine and cysteine in the medium for vegetative cell growth." [PomBase:mah] synonym: "arginine and cysteine auxotrophy" EXACT [PomBase:mah] synonym: "growth auxotrophic for arginine and cysteine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "growth auxotrophic for arginine and cysteine during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000035 ! growth auxotrophic for arginine is_a: FYPO:0000037 ! growth auxotrophic for cysteine created_by: midori creation_date: 2014-06-11T14:41:35Z [Term] id: FYPO:0003429 name: short cytoplasmic microtubules present in decreased numbers def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell contains fewer, and shorter, cytoplasmic microtubules than normal." [PomBase:mah] synonym: "short cytoplasmic microtubules present in decreased numbers during mitotic cell cycle" RELATED [PomBase:mah] synonym: "short cytoplasmic microtubules present in decreased numbers during vegetative growth" EXACT [PomBase:mah] synonym: "short cytoplasmic microtubules present in reduced numbers" EXACT [PomBase:mah] is_a: FYPO:0004638 ! abnormal cellular physical quality phenotype intersection_of: FYPO:0004638 ! abnormal cellular physical quality phenotype intersection_of: has_part FYPO:0002760 ! short cytoplasmic microtubules intersection_of: has_part FYPO:0003430 ! microtubules present in decreased numbers relationship: has_part FYPO:0002760 ! short cytoplasmic microtubules relationship: has_part FYPO:0003430 ! microtubules present in decreased numbers created_by: midori creation_date: 2014-06-11T14:54:21Z [Term] id: FYPO:0003430 name: microtubules present in decreased numbers def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells contain fewer microtubules than normal." [PomBase:mah] synonym: "decreased level of MTs" EXACT [PomBase:mah] synonym: "microtubules present in reduced numbers" EXACT [PomBase:mah] is_a: FYPO:0004315 ! abnormal microtubule cytoskeleton during vegetative growth is_a: PATO:0002001 ! has fewer parts of type intersection_of: PATO:0002001 ! has fewer parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0005874 ! microtubule relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0005874 ! microtubule created_by: midori creation_date: 2014-06-11T14:56:12Z [Term] id: FYPO:0003431 name: abolished histone H3K9me binding def: "A molecular function phenotype in which the binding of a protein to histone H3 methylated on the lysine at position 9 does not occur." [PomBase:mah] comment: This term can be used for any protein-protein interaction that is affected by a mutation, whether or not the mutated gene product is one of the interacting proteins. We recommend noting which proteins were used in the assay when annotating to this term. synonym: "abolished K9-methylated histone H3 binding" EXACT [PomBase:mah] synonym: "abolished protein-histone H3K9me interaction" EXACT [PomBase:mah] synonym: "histone H3K9me binding abolished" EXACT [PomBase:mah] is_a: FYPO:0003247 ! abolished histone H3 binding created_by: midori creation_date: 2014-06-11T14:58:37Z [Term] id: FYPO:0003432 name: normal histone H3K9me binding def: "A molecular function phenotype in which the binding of a protein to histone H3 methylated on the lysine at position 9 is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal K9-methylated histone H3 binding" EXACT [PomBase:mah] synonym: "normal methylated histone H3K9me binding" EXACT [PomBase:al] is_a: FYPO:0000703 ! normal protein binding created_by: midori creation_date: 2014-06-11T15:01:04Z [Term] id: FYPO:0003433 name: abnormal ornithine carbamoyltransferase activity def: "A molecular function phenotype in which the observed rate of ornithine carbamoyltransferase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004585 ! ornithine carbamoyltransferase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004585 ! ornithine carbamoyltransferase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-06-11T15:26:37Z [Term] id: FYPO:0003434 name: decreased ornithine carbamoyltransferase activity def: "A molecular function phenotype in which the observed rate of ornithine carbamoyltransferase activity is decreased." [PomBase:mah] synonym: "reduced ornithine carbamoyltransferase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0003433 ! abnormal ornithine carbamoyltransferase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004585 ! ornithine carbamoyltransferase activity relationship: inheres_in GO:0004585 ! ornithine carbamoyltransferase activity created_by: midori creation_date: 2014-06-11T15:26:44Z [Term] id: FYPO:0003435 name: increased ornithine carbamoyltransferase activity def: "A molecular function phenotype in which the observed rate of ornithine carbamoyltransferase activity is increased." [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0003433 ! abnormal ornithine carbamoyltransferase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0004585 ! ornithine carbamoyltransferase activity relationship: inheres_in GO:0004585 ! ornithine carbamoyltransferase activity created_by: midori creation_date: 2014-06-11T15:27:00Z [Term] id: FYPO:0003436 name: decreased protein kinase activity during mitotic G2 phase def: "A molecular function phenotype in which the observed rate of a protein kinase activity is decreased during the G2 phase of the mitotic cell cycle." [PomBase:mah] synonym: "reduced protein kinase activity during mitotic G2 phase" EXACT [PomBase:mah] is_a: FYPO:0003331 ! decreased protein kinase activity during mitotic interphase intersection_of: PATO:0002052 ! decreased occurrence intersection_of: during GO:0000085 ! mitotic G2 phase intersection_of: inheres_in GO:0004672 ! protein kinase activity relationship: during GO:0000085 ! mitotic G2 phase relationship: inheres_in GO:0004672 ! protein kinase activity created_by: midori creation_date: 2014-06-16T11:26:31Z [Term] id: FYPO:0003437 name: abolished protein kinase activity during mitotic G1 phase def: "A molecular function phenotype in which a protein kinase activity is absent during G1 phase of the mitotic cell cycle." [PomBase:mah] synonym: "protein kinase activity abolished during mitotic G1 phase" EXACT [PomBase:mah] is_a: FYPO:0001384 ! abolished protein kinase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0000080 ! mitotic G1 phase intersection_of: towards GO:0004672 ! protein kinase activity relationship: during GO:0000080 ! mitotic G1 phase relationship: towards GO:0004672 ! protein kinase activity created_by: midori creation_date: 2014-06-16T11:30:42Z [Term] id: FYPO:0003438 name: mitotic G1/S transition delay following nitrogen starvation-induced G1 phase arrest def: "A cell cycle phenotype in which the G1/S transition of the mitotic cell cycle begins later than normal after the cell has been arrested in G1 phase due to nitrogen starvation. The duration of G1 arrest is thus longer than normal." [PMID:8657126, PomBase:mah] comment: A G1/S delay may indicate that a checkpoint, such as the cell size checkpoint or the G1/S DNA damage checkpoint, is activated. Checkpoint activation can be tested using checkpoint kinase mutants. synonym: "delayed cell cycle progression through mitotic G1/S phase transition following cell cycle arrest in mitotic G1 phase in response to nitrogen starvation" EXACT [PomBase:mah] synonym: "delayed mitotic G1 phase progression following nitrogen starvation-induced G1 phase arrest" RELATED [PomBase:mah] synonym: "increased duration of nitrogen starvation-induced mitotic G1 phase arrest" RELATED [PomBase:mah] synonym: "mitotic cell cycle delay at G1/S transition following nitrogen starvation-induced G1 phase arrest" EXACT [PomBase:mah] synonym: "mitotic G1/S transition delay after recovery from nitrogen starvation-induced G1 arrest" EXACT [PMID:8657126, PomBase:vw] is_a: FYPO:0000333 ! mitotic G1/S transition delay created_by: midori creation_date: 2014-06-16T11:54:10Z [Term] id: FYPO:0003439 name: branched septum def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell forms a septum that has branches. For example, the septum may be Y-shaped." [PMID:24798735, PomBase:mah] synonym: "branched septum during mitotic cell cycle" RELATED [PomBase:mah] synonym: "branched septum during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002023 ! abnormal septum morphology during vegetative growth is_a: PATO:0000402 ! branched intersection_of: PATO:0000402 ! branched intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000935 ! barrier septum relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000935 ! barrier septum created_by: midori creation_date: 2014-06-16T12:06:23Z [Term] id: FYPO:0003440 name: cell lysis during cytokinesis def: "An inviable phenotype observed in the vegetative growth phase of the life cycle in which a cell lyses, i.e. the plasma membrane ruptures and cytoplasm is lost, during cytokinesis. Note that in fission yeast cell lysis, the integrity of the cell wall is also compromised." [PMID:24798735, PomBase:mah] synonym: "cell lysis during cytokinesis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "cell lysis during cytokinesis during vegetative growth" EXACT [PomBase:mah] synonym: "cytolysis during cytokinesis" EXACT [PomBase:mah] synonym: "inviable, lysed cell during cytokinesis" EXACT [PomBase:mah] is_a: FYPO:0000647 ! vegetative cell lysis intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0000281 ! mitotic cytokinesis intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0019835 ! cytolysis relationship: happens_during GO:0000281 ! mitotic cytokinesis relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0019835 ! cytolysis created_by: midori creation_date: 2014-06-16T12:21:54Z [Term] id: FYPO:0003441 name: normal protein localization to actin cytoskeleton def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to all or part of the actin cytoskeleton is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to actin cytoskeleton" EXACT [PomBase:mah] synonym: "normal protein localization to actin cytoskeleton during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to actin cytoskeleton during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003184 ! normal protein localization to cytoskeleton during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903119 ! protein localization to actin cytoskeleton intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903119 ! protein localization to actin cytoskeleton relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-06-16T12:40:07Z [Term] id: FYPO:0003442 name: abolished protein localization to actin cable def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to one or more actin cables does not occur. Actin cables are the form of actin filament bundles found in yeasts." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to actin cable" EXACT [PomBase:mah] synonym: "abolished protein localization to actin cable during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to actin cable during vegetative growth" EXACT [PomBase:mah] synonym: "abolished protein localization to actin filament bundle" EXACT [GO:0032432] synonym: "protein absent from actin cable" RELATED [PomBase:mah] synonym: "protein localization to actin cable abolished" EXACT [PomBase:mah] is_a: FYPO:0001179 ! protein localization abolished during vegetative growth intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1903120 ! protein localization to actin filament bundle relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1903120 ! protein localization to actin filament bundle created_by: midori creation_date: 2014-06-16T12:46:59Z [Term] id: FYPO:0003443 name: decreased medial cortical node movement during contractile ring assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which medial cortical nodes move less frequently, and over shorter distances, than normal. During contractile ring assembly, medial cortical nodes normally move towards the cell center, and condense into a ring." [PMID:24798735, PomBase:al, PomBase:mah] synonym: "decreased medial cortical node movement during contractile ring assembly" EXACT [PomBase:vw] synonym: "reduced medial cortical node movement during contractile ring assembly" EXACT [PomBase:mah] is_a: FYPO:0000032 ! abnormal cytokinesis created_by: midori creation_date: 2014-06-16T12:56:48Z [Term] id: FYPO:0003444 name: abnormal medial cortical node migration def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which medial cortical nodes move in random directions such that they do not undergo an overall migration towards the cell center. During contractile ring assembly, medial cortical nodes normally move towards the cell center, and condense into a ring." [PMID:24798735, PomBase:al, PomBase:mah] is_a: FYPO:0000032 ! abnormal cytokinesis created_by: midori creation_date: 2014-06-16T13:01:12Z [Term] id: FYPO:0003445 name: increased duration of DNA damage checkpoint during cellular response to UV def: "A cell cycle checkpoint phenotype in which the duration of cell cycle arrest or delay due to regulation by any DNA damage checkpoint is greater than in wild type during a cellular response to ultraviolet light." [PomBase:mah] synonym: "delayed DNA damage checkpoint deactivation during cellular response to UV" EXACT [PomBase:mah] synonym: "prolonged DNA damage checkpoint during cellular response to UV" EXACT [PomBase:mah] is_a: FYPO:0002341 ! increased duration of DNA damage checkpoint is_a: FYPO:0002900 ! abnormal DNA damage checkpoint during cellular response to UV intersection_of: PATO:0000498 ! increased duration intersection_of: during GO:0034644 ! cellular response to UV intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000077 ! DNA damage checkpoint relationship: during GO:0034644 ! cellular response to UV relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000077 ! DNA damage checkpoint created_by: midori creation_date: 2014-06-16T13:23:07Z [Term] id: FYPO:0003446 name: decreased SRP-dependent cotranslational protein targeting to membrane def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of SRP-dependent cotranslational protein targeting to the ER membrane is decreased." [GO:0006614, PomBase:mah] synonym: "decreased SRP-dependent cotranslational protein targeting to membrane during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased SRP-dependent cotranslational protein targeting to membrane during vegetative growth" EXACT [PomBase:mah] synonym: "reduced SRP-dependent cotranslational protein targeting to membrane" EXACT [PomBase:mah] is_a: FYPO:0000215 ! abnormal intracellular protein transport is_a: FYPO:0000464 ! decreased intracellular transport is_a: FYPO:0000536 ! abnormal protein secretion is_a: FYPO:0000541 ! decreased protein transport intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane created_by: midori creation_date: 2014-06-16T13:37:29Z [Term] id: FYPO:0003447 name: decreased level of glycosylated protein in cell def: "A cell phenotype in which the amount of glycosylated protein measured the cell is higher than normal when the cell is in the vegetative growth phase of the life cycle. Total protein or a specific protein may be affected." [PomBase:mah] synonym: "decreased accumulation of glycosylated protein in cell" RELATED [PomBase:mah] synonym: "decreased cellular glycoprotein level" EXACT [PR:000037069] synonym: "decreased glycosylated protein level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased level of glycosylated protein in cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased level of glycosylated protein in cell during vegetative growth" EXACT [PomBase:mah] synonym: "reduced level of glycosylated protein in cell" EXACT [PomBase:mah] is_a: FYPO:0001324 ! decreased protein level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards PR:000037069 relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards PR:000037069 created_by: midori creation_date: 2014-06-16T13:49:35Z [Term] id: FYPO:0003448 name: viable swollen vacuolated spheroid vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is viable, is shaped in the form of a spheroid, has a larger volume than normal, and in which vacuoles are more visible (usually by microscopy) than normal. In a swollen cell, both length and diameter are greater than normal, although the cell is only considered elongated if the length:width ratio is also greater than normal." [PomBase:mah] synonym: "viable enlarged vacuolated spheroid vegetative cell" RELATED [PomBase:mah] synonym: "viable enlarged volume vacuolated spheroid vegetative cell" EXACT [PomBase:mah] synonym: "viable large vacuolated spheroid vegetative cell" RELATED [PomBase:vw] synonym: "viable swollen rounded vacuolated vegetative cell" EXACT [PomBase:mah] synonym: "viable swollen vacuolated spheroid cell during vegetative growth" EXACT [PomBase:mah] synonym: "viable swollen vacuolated spheroid vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0004559 ! viable swollen spheroid vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000021 ! spheroid vegetative cell intersection_of: has_part FYPO:0000025 ! swollen cell intersection_of: has_part FYPO:0001491 ! viable vegetative cell intersection_of: has_part FYPO:0001581 ! vacuolated relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000021 ! spheroid vegetative cell relationship: has_part FYPO:0000025 ! swollen cell relationship: has_part FYPO:0001491 ! viable vegetative cell relationship: has_part FYPO:0001581 ! vacuolated created_by: midori creation_date: 2014-06-16T13:51:06Z [Term] id: FYPO:0003449 name: abnormal cell cycle arrest at mitotic G1/S phase transition def: "A cellular process phenotype in which progression through the mitotic cell cycle is arrested at the mitotic G1/S phase transition, under conditions where arrest is not a normal occurrence." [PomBase:mah] comment: Use this term if the cell cycle is abnormally arrested after completion of DNA replication (S phase) but before the G2/M transition. synonym: "abnormal cell cycle arrest at mitotic G1/S phase transition during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal cell cycle arrest with unreplicated DNA at mitotic G1/S phase transition" EXACT [PomBase:vw] synonym: "abnormal mitotic cell cycle arrest at G1/S phase transition" EXACT [PomBase:mah] is_a: FYPO:0000395 ! cell cycle arrest at mitotic G1/S phase transition is_a: FYPO:0001028 ! abnormal cell cycle arrest in mitotic interphase is_a: FYPO:0001430 ! abnormal mitotic cell cycle arrest with unreplicated DNA intersection_of: PATO:0001561 ! having extra processual parts intersection_of: during GO:0000082 ! G1/S transition of mitotic cell cycle intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0071850 ! mitotic cell cycle arrest relationship: during GO:0000082 ! G1/S transition of mitotic cell cycle relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0071850 ! mitotic cell cycle arrest created_by: midori creation_date: 2014-06-24T11:44:29Z [Term] id: FYPO:0003450 name: abolished protein localization to nucleus def: "A cell phenotype in which the localization of a protein to the nucleus is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to nucleus" EXACT [PomBase:mah] synonym: "protein localization to nucleus abolished" EXACT [PomBase:mah] is_a: FYPO:0001375 ! protein localization abolished is_a: FYPO:0002956 ! abnormal protein localization to nucleus intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0034504 ! protein localization to nucleus relationship: towards GO:0034504 ! protein localization to nucleus created_by: midori creation_date: 2014-06-24T12:15:23Z [Term] id: FYPO:0003451 name: abolished protein localization to nucleus during meiotic anaphase II def: "A cell phenotype in which the localization of a protein to the nucleus is abolished during anaphase of the second meiotic nuclear division." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to nucleus during meiotic anaphase II" EXACT [PomBase:mah] synonym: "abolished protein localization to nucleus during anaphase II" EXACT [PomBase:al] synonym: "protein localization to nucleus abolished during meiotic anaphase II" EXACT [PomBase:mah] is_a: FYPO:0003450 ! abolished protein localization to nucleus intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0007138 ! meiotic anaphase II intersection_of: towards GO:0034504 ! protein localization to nucleus relationship: during GO:0007138 ! meiotic anaphase II relationship: towards GO:0034504 ! protein localization to nucleus created_by: midori creation_date: 2014-06-24T12:17:48Z [Term] id: FYPO:0003452 name: mislocalized protein def: "A cell phenotype in which a protein is observed in a particular location where it is not normally found." [PomBase:mah] comment: The difference between this term and 'abnormal protein localization' (FYPO:0000443) is that 'mislocalized protein' describes a protein that is observed in a place where it is not normally found, whereas 'abnormal protein localization' additionally encompasses the absence of protein from a place where it is normally found. FYPO:0003452 and its descendants can therefore be used in any case where a protein is in a different location in a mutant compared to wild type, whereas additional information is usually required to support annotation to FYPO:0000443 or its descendants. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "mislocalised protein" EXACT [PomBase:mah] is_a: FYPO:0003037 ! abnormal cell phenotype is_a: FYPO:0004638 ! abnormal cellular physical quality phenotype is_a: PATO:0000628 ! mislocalised intersection_of: PATO:0000628 ! mislocalised intersection_of: inheres_in CHEBI:36080 ! protein relationship: inheres_in CHEBI:36080 ! protein relationship: output_of FYPO:0001370 ! abnormal protein localization created_by: midori creation_date: 2014-06-24T12:20:58Z [Term] id: FYPO:0003453 name: protein mislocalized to nucleus def: "A cell phenotype in which a protein that is not normally found in the nucleus is observed there." [PomBase:mah] comment: Note that this term can be used to annotate any case where a protein is found in the nucleus in a mutant, but not in wild type. In some cases, there may be enough additional information to annotate to 'abnormal protein localization' (FYPO:0000443) or one of its descendants. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "ectopic protein localization to nucleus" EXACT [PomBase:vw] synonym: "protein mislocalised to nucleus" EXACT [PomBase:mah] is_a: FYPO:0003452 ! mislocalized protein intersection_of: PATO:0000628 ! mislocalised intersection_of: inheres_in CHEBI:36080 ! protein intersection_of: towards GO:0005634 ! nucleus relationship: inheres_in CHEBI:36080 ! protein relationship: towards GO:0005634 ! nucleus created_by: midori creation_date: 2014-06-24T12:22:14Z [Term] id: FYPO:0003454 name: protein mislocalized to nucleus during meiosis I def: "A cell phenotype in which a protein that is not normally found in the nucleus is observed there during the first meiotic nuclear division." [PomBase:mah] comment: Note that this term can be used to annotate any case where a protein is found in the nucleus in a mutant, but not in wild type. In some cases, there may be enough additional information to annotate to 'abnormal protein localization' (FYPO:0000443) or one of its descendants. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "ectopic protein localization to nucleus during meiosis I" EXACT [PomBase:vw] synonym: "protein mislocalised to nucleus during meiosis I" EXACT [PomBase:mah] is_a: FYPO:0003453 ! protein mislocalized to nucleus intersection_of: PATO:0000628 ! mislocalised intersection_of: exists_during GO:0007127 ! meiosis I intersection_of: inheres_in CHEBI:36080 ! protein intersection_of: towards GO:0005634 ! nucleus relationship: exists_during GO:0007127 ! meiosis I relationship: inheres_in CHEBI:36080 ! protein relationship: towards GO:0005634 ! nucleus created_by: midori creation_date: 2014-06-24T12:29:34Z [Term] id: FYPO:0003455 name: decreased arginine catabolic process to proline def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of the breakdown of arginine into other compounds, including proline, is decreased." [GO:0019493, PomBase:mah] synonym: "decreased arginine catabolic process to proline during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased arginine catabolic process to proline during vegetative growth" EXACT [PomBase:mah] synonym: "decreased arginine catabolism to proline" EXACT [PomBase:mah] synonym: "reduced arginine catabolic process to proline" EXACT [PomBase:mah] is_a: FYPO:0001348 ! cellular metabolism phenotype during vegetative growth is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0019493 ! arginine catabolic process to proline relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0019493 ! arginine catabolic process to proline created_by: midori creation_date: 2014-06-24T12:50:35Z [Term] id: FYPO:0003456 name: growth auxotrophic for methionine and purine def: "Auxotrophy in which a cell is unable to synthesize methionine or purines, and therefore requires methionine and at least one purine in the medium for vegetative cell growth." [PomBase:mah] synonym: "growth auxotrophic for methionine and purine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "growth auxotrophic for methionine and purine during vegetative growth" EXACT [PomBase:mah] synonym: "methionine and purine auxotrophy" EXACT [PomBase:mah] is_a: FYPO:0000040 ! growth auxotrophic for methionine intersection_of: PATO:0000422 ! auxotrophic intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:16811 ! methionine intersection_of: towards CHEBI:35584 ! purine relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:16811 ! methionine relationship: towards CHEBI:35584 ! purine created_by: midori creation_date: 2014-06-24T13:28:57Z [Term] id: FYPO:0003457 name: increased cellular homocysteine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of homocysteine measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular homocysteine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular homocysteine level during vegetative growth" EXACT [PomBase:mah] synonym: "increased homocysteine accumulation" RELATED [PomBase:mah] is_a: FYPO:0003986 ! increased cellular amino acid level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:17230 ! homocysteine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:17230 ! homocysteine created_by: midori creation_date: 2014-06-24T13:36:34Z [Term] id: FYPO:0003458 name: alpha,alpha-trehalase activity increase abolished during cellular response to salt stress def: "A molecular function phenotype in which the observed rate of alpha,alpha-trehalase activity does not increase as a result of a salt stress stimulus." [PomBase:mah] synonym: "absent increase in trehalase activity in response to salt stress" EXACT [PomBase:al] synonym: "neutral trehalase activity increase abolished during cellular response to salt stress" EXACT [PomBase:mah] synonym: "trehalase activity increase abolished during cellular response to salt stress" BROAD [GO:0004555, GO:0015927] is_a: FYPO:0001479 ! abnormal alpha,alpha-trehalase activity created_by: midori creation_date: 2014-06-24T13:40:09Z [Term] id: FYPO:0003459 name: decreased cellular trehalose level during cellular response to salt stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of trehalose measured in a cell is lower than normal when the cell is subject to salt stress." [PomBase:mah] synonym: "decreased cellular trehalose level during cellular response to salt stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular trehalose level during vegetative growth and during cellular response to salt stress" EXACT [PomBase:mah] synonym: "decreased cellular trehalose level in response to salt stress" EXACT [PomBase:al] synonym: "decreased trehalose accumulation during cellular response to salt stress" RELATED [PomBase:mah] synonym: "reduced cellular trehalose level during cellular response to salt stress" EXACT [PomBase:mah] is_a: FYPO:0001329 ! decreased level of substance in cell during vegetative growth is_a: FYPO:0001447 ! decreased cellular trehalose level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0071472 ! cellular response to salt stress intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:27082 ! trehalose relationship: exists_during GO:0071472 ! cellular response to salt stress relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:27082 ! trehalose created_by: midori creation_date: 2014-06-24T14:03:51Z [Term] id: FYPO:0003460 name: decreased cellular trehalose level during cellular response to oxidative stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of trehalose measured in a cell is lower than normal when the cell is subject to oxidative stress." [PomBase:mah] synonym: "decreased cellular trehalose level during cellular response to oxidative stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular trehalose level during vegetative growth and during cellular response to oxidative stress" EXACT [PomBase:mah] synonym: "decreased cellular trehalose level in response to oxidative stress" EXACT [PomBase:al] synonym: "decreased trehalose accumulation during cellular response to oxidative stress" RELATED [PomBase:mah] synonym: "reduced cellular trehalose level during cellular response to oxidative stress" EXACT [PomBase:mah] is_a: FYPO:0001329 ! decreased level of substance in cell during vegetative growth is_a: FYPO:0001447 ! decreased cellular trehalose level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0034599 ! cellular response to oxidative stress intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:27082 ! trehalose relationship: exists_during GO:0034599 ! cellular response to oxidative stress relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:27082 ! trehalose created_by: midori creation_date: 2014-06-24T14:05:22Z [Term] id: FYPO:0003461 name: normal cellular trehalose level during cellular response to salt stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of trehalose measured in a cell is normal (i.e. indistinguishable from wild type) when the cell is subject to salt stress." [PomBase:mah] synonym: "normal cellular trehalose accumulation during cellular response to salt stress" RELATED [PomBase:mah] synonym: "normal cellular trehalose level during cellular response to salt stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular trehalose level during cellular response to salt stress during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001449 ! normal cellular trehalose level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0071472 ! cellular response to salt stress intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:27082 ! trehalose relationship: exists_during GO:0071472 ! cellular response to salt stress relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:27082 ! trehalose created_by: midori creation_date: 2014-06-24T14:06:56Z [Term] id: FYPO:0003462 name: normal cellular trehalose level during cellular response to oxidative stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of trehalose measured in a cell is normal (i.e. indistinguishable from wild type) when the cell is subject to oxidative stress." [PomBase:mah] synonym: "normal cellular trehalose accumulation during cellular response to oxidative stress" RELATED [PomBase:mah] synonym: "normal cellular trehalose level during cellular response to oxidative stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular trehalose level during cellular response to oxidative stress during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001449 ! normal cellular trehalose level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0034599 ! cellular response to oxidative stress intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:27082 ! trehalose relationship: exists_during GO:0034599 ! cellular response to oxidative stress relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:27082 ! trehalose created_by: midori creation_date: 2014-06-24T14:08:13Z [Term] id: FYPO:0003463 name: abolished alpha,alpha-trehalase activity def: "A molecular function phenotype in which alpha,alpha-trehalase activity is absent." [PomBase:mah] synonym: "abolished neutral trehalase activity" EXACT [PomBase:mah] synonym: "abolished trehalase activity" BROAD [GO:0004555] synonym: "alpha,alpha-trehalase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0001479 ! abnormal alpha,alpha-trehalase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0004555 ! alpha,alpha-trehalase activity relationship: towards GO:0004555 ! alpha,alpha-trehalase activity created_by: midori creation_date: 2014-06-24T14:14:04Z [Term] id: FYPO:0003464 name: decreased alpha,alpha-trehalase activity during cellular response to heat def: "A molecular function phenotype in which the observed rate of alpha,alpha-trehalase activity is lower than normal during a cellular response to heat." [PomBase:mah] synonym: "decreased neutral trehalase activity during cellular response to heat" EXACT [PomBase:mah] synonym: "decreased trehalase activity during cellular response to heat" BROAD [GO:0004555, GO:0015927] synonym: "reduced alpha,alpha-trehalase activity during cellular response to heat" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0001479 ! abnormal alpha,alpha-trehalase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: during GO:0034605 ! cellular response to heat intersection_of: inheres_in GO:0004555 ! alpha,alpha-trehalase activity relationship: during GO:0034605 ! cellular response to heat relationship: inheres_in GO:0004555 ! alpha,alpha-trehalase activity created_by: midori creation_date: 2014-06-24T14:24:58Z [Term] id: FYPO:0003465 name: decreased alpha,alpha-trehalase activity during cellular response to salt stress def: "A molecular function phenotype in which the observed rate of alpha,alpha-trehalase activity is lower than normal during a cellular response to salt stress." [PomBase:mah] synonym: "decreased neutral trehalase activity during cellular response to salt stress" EXACT [PomBase:mah] synonym: "decreased trehalase activity during cellular response to salt stress" BROAD [GO:0004555, GO:0015927] synonym: "reduced alpha,alpha-trehalase activity during cellular response to v" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0001479 ! abnormal alpha,alpha-trehalase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: during GO:0071472 ! cellular response to salt stress intersection_of: inheres_in GO:0004555 ! alpha,alpha-trehalase activity relationship: during GO:0071472 ! cellular response to salt stress relationship: inheres_in GO:0004555 ! alpha,alpha-trehalase activity created_by: midori creation_date: 2014-06-24T14:27:25Z [Term] id: FYPO:0003466 name: normal cellular trehalose level during cellular response to heat def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of trehalose measured in a cell is normal (i.e. indistinguishable from wild type) when the cell is subject to a heat stimulus." [PomBase:mah] synonym: "normal cellular trehalose accumulation during cellular response to heat" RELATED [PomBase:mah] synonym: "normal cellular trehalose level during cellular response to heat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular trehalose level during cellular response to heat during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001449 ! normal cellular trehalose level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0034605 ! cellular response to heat intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:27082 ! trehalose relationship: exists_during GO:0034605 ! cellular response to heat relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:27082 ! trehalose created_by: midori creation_date: 2014-06-24T14:28:19Z [Term] id: FYPO:0003467 name: altered splice site specificity def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which RNA splice site specificity differs from normal. For example, different exons may be included or excluded, or introns in which the normally recognized 3' splice site AG nucleotides are mutated may be spliced." [PMID:1617727, PMID:17130122, PomBase:mah] synonym: "abnormal splice site specificity" EXACT [PomBase:mah] is_a: FYPO:0002915 ! abnormal RNA splicing created_by: midori creation_date: 2014-06-24T14:40:45Z [Term] id: FYPO:0003468 name: normal RNA splicing def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which RNA splicing is normal (i.e. indistinguishable from wild type). All RNA splicing may be normal, or one splicing of or more specific RNA molecules may be specifically assayed." [PomBase:mah] synonym: "normal RNA splicing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal RNA splicing during vegetative growth" EXACT [PomBase:mah] synonym: "normal RNA splicing, via transesterification reactions with bulged adenosine as nucleophile" EXACT [GO:0000377] is_a: FYPO:0000294 ! RNA metabolism phenotype is_a: FYPO:0001980 ! normal RNA processing intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-06-24T14:46:38Z [Term] id: FYPO:0003469 name: normal snRNA splicing def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which small nuclear RNA (snRNA) splicing is normal (i.e. indistinguishable from wild type). All snRNA splicing may be normal, or one splicing of or more specific snRNA molecules may be specifically assayed." [PomBase:mah] synonym: "normal snRNA splicing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal snRNA splicing during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003468 ! normal RNA splicing intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards SO:0000231 ! snRNA_primary_transcript relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile relationship: qualifier PATO:0000461 ! normal relationship: towards SO:0000231 ! snRNA_primary_transcript created_by: midori creation_date: 2014-06-24T14:47:50Z [Term] id: FYPO:0003470 name: increased mRNA splicing, via spliceosome def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of mRNA splicing via the spliceosome is increased." [PMID:24298023, PomBase:mah] synonym: "increased mRNA splicing, via spliceosome during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased mRNA splicing, via spliceosome during vegetative growth" EXACT [PomBase:mah] synonym: "increased nuclear mRNA splicing, via spliceosome" EXACT [PomBase:mah] synonym: "increased splicing" BROAD [PomBase:al] is_a: FYPO:0000189 ! abnormal mRNA splicing, via spliceosome is_a: FYPO:0002916 ! increased RNA splicing intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000398 ! mRNA splicing, via spliceosome relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000398 ! mRNA splicing, via spliceosome created_by: midori creation_date: 2014-06-24T14:49:33Z [Term] id: FYPO:0003471 name: multiseptate cell during cellular response to salt stress def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell has more than one septum apiece during a cellular response to salt stress." [PomBase:mah] synonym: "multiseptate cell during cellular response to salt stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "multiseptate cell during cellular response to salt stress during vegetative growth" EXACT [PomBase:mah] synonym: "multiseptate in response to salt stress" EXACT [PomBase:al] is_a: FYPO:0000118 ! multiseptate vegetative cell intersection_of: FYPO:0000118 ! multiseptate vegetative cell intersection_of: exists_during GO:0071472 ! cellular response to salt stress intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: exists_during GO:0071472 ! cellular response to salt stress relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) created_by: midori creation_date: 2014-06-24T15:00:17Z [Term] id: FYPO:0003472 name: cut during cellular response to salt stress def: "A cut phenotype that is observed when a cell is subject to salt stress. In a cut phenotype, a cell undergoes septation despite abnormal chromosome segregation, such that the septum physically divides the nucleus into two parts, and produces inviable daughter cells." [PomBase:mah] synonym: "cut during cellular response to salt stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "cut during cellular response to salt stress during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003165 ! cut intersection_of: FYPO:0003165 ! cut intersection_of: during GO:0071472 ! cellular response to salt stress relationship: during GO:0071472 ! cellular response to salt stress created_by: midori creation_date: 2014-06-24T15:01:30Z [Term] id: FYPO:0003473 name: septation following abnormal chromosome segregation, with binucleate cell formation during cellular response to salt stress def: "An inviable phenotype observed in the vegetative growth phase of the life cycle in which a cell undergoes septation despite abnormal chromosome segregation, producing inviable daughter cells, and in which the septum forms in a position that partitions both nuclei into one daughter cell, when the cell is subject to salt stress." [PomBase:mah, PomBase:vw] is_a: FYPO:0003166 ! septation following abnormal chromosome segregation, with anucleate cell formation created_by: midori creation_date: 2014-06-24T15:05:37Z [Term] id: FYPO:0003474 name: fragmented nucleus during cellular response to salt stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which nucleus is broken into multiple small fragments that are smaller than a normal nucleus, hen the cell is subject to salt stress." [PomBase:mah] synonym: "fragmented nucleus during cellular response to salt stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "fragmented nucleus during cellular response to salt stress during vegetative growth" EXACT [PomBase:mah] synonym: "loss of nuclear integrity during cellular response to salt stress" RELATED [PomBase:al] is_a: FYPO:0001919 ! fragmented nucleus intersection_of: PATO:0001444 ! broken intersection_of: exists_during GO:0071472 ! cellular response to salt stress intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005634 ! nucleus relationship: exists_during GO:0071472 ! cellular response to salt stress relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005634 ! nucleus created_by: midori creation_date: 2014-06-24T15:12:19Z [Term] id: FYPO:0003475 name: abnormal arsenate reductase activity def: "A molecular function phenotype in which the observed rate of arsenate reductase activity is abnormal." [PomBase:mah] is_a: FYPO:0000689 ! abnormal oxidoreductase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0030611 ! arsenate reductase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0030611 ! arsenate reductase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-06-24T15:22:07Z [Term] id: FYPO:0003476 name: decreased arsenate reductase activity def: "A molecular function phenotype in which the observed rate of arsenate reductase activity is decreased." [PomBase:mah] synonym: "reduced arsenate reductase activity" EXACT [PomBase:mah] is_a: FYPO:0000690 ! decreased oxidoreductase activity is_a: FYPO:0003475 ! abnormal arsenate reductase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0030611 ! arsenate reductase activity relationship: inheres_in GO:0030611 ! arsenate reductase activity created_by: midori creation_date: 2014-06-24T15:22:14Z [Term] id: FYPO:0003477 name: abolished protein phosphorylation during cellular response to arsenic-containing substance def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, does not occur during a cellular response to an arsenic-containing substance such as arsenate." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein phosphorylation during cellular response to arsenate" NARROW [PMID:22912829, PomBase:mah] synonym: "abolished protein phosphorylation during cellular response to arsenic-containing substance during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein phosphorylation during cellular response to arsenic-containing substance during vegetative growth" EXACT [PomBase:mah] synonym: "protein phosphorylation abolished during cellular response to arsenic-containing substance" EXACT [PomBase:mah] is_a: FYPO:0002033 ! abolished protein phosphorylation during vegetative growth intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0071243 ! cellular response to arsenic-containing substance intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0006468 ! protein phosphorylation relationship: during GO:0071243 ! cellular response to arsenic-containing substance relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2014-06-24T15:28:25Z [Term] id: FYPO:0003478 name: signal transduction phenotype def: "A cellular process phenotype that affects signal transduction. Signal transduction is the process in which a signal is conveyed to trigger a change in the activity or state of a cell. It begins with reception of a signal and ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. A phenotype may affect one or more steps in one or more signal transduction pathways." [GO:0007165, PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "fission yeast signal transduction phenotype" EXACT [PomBase:mah] is_a: FYPO:0000145 ! regulation phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: inheres_in_part_of GO:0007165 ! signal transduction relationship: inheres_in_part_of GO:0007165 ! signal transduction created_by: midori creation_date: 2014-07-01T12:26:39Z [Term] id: FYPO:0003479 name: constitutively activated MAPK cascade involved in cell wall organization or biogenesis def: "A signal transduction phenotype in which the MAPK cascade involved in cell wall organization or biogenesis is activated continuously." [PMID:23934882, PomBase:mah] synonym: "constitutively activated Pmk1 MAPK cell integrity signaling" NARROW [GO:0000196, PomBase:vw] synonym: "continuous MAPK cascade involved in cell wall organization or biogenesis" EXACT [PomBase:mah] is_a: FYPO:0001334 ! regulation phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0003478 ! signal transduction phenotype is_a: PATO:0000689 ! continuous intersection_of: PATO:0000689 ! continuous intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000196 ! MAPK cascade involved in cell wall organization or biogenesis relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000196 ! MAPK cascade involved in cell wall organization or biogenesis created_by: midori creation_date: 2014-07-01T12:29:40Z [Term] id: FYPO:0003480 name: queuosine absent from tRNA def: "A phenotype in which one or more transfer RNA (tRNA) molecules contains no queuosine residues." [PMID:24911101, PomBase:mah] synonym: "reduced queuosine content of tRNA" EXACT [PomBase:vw] synonym: "reduced queuosine level in tRNA" EXACT [PomBase:mah] is_a: FYPO:0003427 ! decreased queuosine level in tRNA created_by: midori creation_date: 2014-07-01T13:04:14Z [Term] id: FYPO:0003481 name: viable elongated vegetative cell, elongated upon mitotic entry def: "A cell morphology phenotype in which a vegetative cell is viable and longer than normal, and in which mitosis begins when the cell is longer than normal." [PMID:24013504, PomBase:mah] synonym: "viable elongated vegetative cell with entry into mitosis at increased length" EXACT [PomBase:vw] synonym: "viable elongated vegetative cell with mitotic entry at increased length" EXACT [PomBase:mah] synonym: "viable elongated vegetative cell, elongated upon entry into mitosis" EXACT [PomBase:mah] is_a: FYPO:0001492 ! viable elongated vegetative cell relationship: output_of FYPO:0000012 ! mitotic G2/M transition delay created_by: midori creation_date: 2014-07-01T13:27:12Z [Term] id: FYPO:0003482 name: increased punctate cytoplasmic protein localization def: "A cell phenotype in which a protein that is normally localized to discrete regions in the cytoplasm, visible as foci or dots by fluorescence microscopy, is abnormally localized such that more dots are observed than in normal (wild type) cells." [PomBase:mah] synonym: "increased protein localization to cytoplasmic puncta" EXACT [PomBase:vw] synonym: "increased punctate cytoplasmic protein localisation" EXACT [PomBase:mah] synonym: "increased punctate cytoplasmic protein localization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased punctate cytoplasmic protein localization during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000782 ! mislocalized protein during vegetative growth created_by: midori creation_date: 2014-07-01T13:51:07Z [Term] id: FYPO:0003483 name: decreased punctate nuclear protein localization during cellular response to ionizing radiation def: "A cell phenotype in which a protein that is normally localized to discrete regions in the nucleus, visible as foci or dots by fluorescence microscopy, is abnormally localized such that fewer dots are observed than in normal (wild type) cells during a cellular response to ionizing radiation." [PomBase:mah] synonym: " decreased punctate nuclear protein localization during cellular response to IR" EXACT [PomBase:mah] synonym: "decreased punctate nuclear protein localisation during cellular response to ionising radiation" EXACT [PomBase:mah] synonym: "decreased punctate nuclear protein localization during cellular response to ionizing radiation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased punctate nuclear protein localization during cellular response to ionizing radiation during vegetative growth" EXACT [PomBase:mah] synonym: "reduced punctate nuclear protein localization during cellular response to ionizing radiation" EXACT [PomBase:mah] is_a: FYPO:0002624 ! decreased punctate nuclear protein localization created_by: midori creation_date: 2014-07-01T15:39:31Z [Term] id: FYPO:0003484 name: abolished protein localization to mitotic spindle midzone def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the mitotic spindle midzone does not occur. The mitotic spindle midzone is the area in the center of the mitotic spindle where the spindle microtubules from opposite poles overlap." [GO:1902967, GO:1990023, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "protein absent from mitotic spindle midzone" RELATED [PomBase:mah] synonym: "protein localisation to mitotic spindle midzone abolished" EXACT [PomBase:mah] synonym: "protein localization to mitotic spindle midzone abolished" EXACT [PomBase:mah] synonym: "protein localization to spindle midzone abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003186 ! abolished protein localization to mitotic spindle intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1902967 ! protein localization to mitotic spindle midzone relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1902967 ! protein localization to mitotic spindle midzone created_by: midori creation_date: 2014-07-01T15:44:04Z [Term] id: FYPO:0003485 name: abolished DNA synthesis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the biosynthesis of DNA does not occur." [GO:0071897, PomBase:mah] synonym: "abolished DNA biosynthesis" EXACT [GO:0071897] synonym: "abolished DNA biosynthetic process" EXACT [GO:0071897] synonym: "abolished DNA synthesis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished DNA synthesis during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000860 ! abnormal metabolic process is_a: FYPO:0001334 ! regulation phenotype during vegetative growth is_a: FYPO:0001346 ! DNA metabolism phenotype during vegetative growth is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards GO:0071897 ! DNA biosynthetic process relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: qualifier PATO:0000460 ! abnormal relationship: towards GO:0071897 ! DNA biosynthetic process created_by: midori creation_date: 2014-07-01T15:52:26Z [Term] id: FYPO:0003486 name: abolished protein localization to double-strand break site def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the region of a chromosome at which a DNA double-strand break has occurred is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to double-strand break site" EXACT [PomBase:mah] synonym: "abolished protein localization to double-strand break site during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to double-strand break site during vegetative growth" EXACT [PomBase:mah] synonym: "abolished protein localization to site of double-strand break" EXACT [PomBase:mah] synonym: "protein localization to double-strand break site abolished" EXACT [PomBase:mah] is_a: FYPO:0002473 ! abnormal protein localization to double-strand break site is_a: FYPO:0002841 ! abolished protein localization to chromosome intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1990166 ! protein localization to site of double-strand break relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1990166 ! protein localization to site of double-strand break created_by: midori creation_date: 2014-07-01T16:23:35Z [Term] id: FYPO:0003487 name: cut during cellular response to ionizing radiation def: "A cut phenotype that is observed when a cell is exposed to ionizing radiation. In a cut phenotype, a cell undergoes septation despite abnormal chromosome segregation, such that the septum physically divides the nucleus into two parts, and produces inviable daughter cells." [PomBase:mah] synonym: "cut during cellular response to ionizing radiation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "cut during cellular response to ionizing radiation during vegetative growth" EXACT [PomBase:mah] synonym: "cut during cellular response to IR" EXACT [PomBase:mah] is_a: FYPO:0003165 ! cut intersection_of: FYPO:0003165 ! cut intersection_of: during GO:0071479 ! cellular response to ionizing radiation relationship: during GO:0071479 ! cellular response to ionizing radiation created_by: midori creation_date: 2014-07-01T16:26:15Z [Term] id: FYPO:0003488 name: elongated cell during cellular response to ionizing radiation def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is elongated during a cellular response to ionizing radiation." [PomBase:mah] synonym: "elongated cell during cellular response to ionizing radiation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "elongated cell during cellular response to ionizing radiation during vegetative growth" EXACT [PomBase:mah] synonym: "elongated cell during cellular response to IR" EXACT [PomBase:mah] synonym: "elongated in response to ionizing radiation" EXACT [PomBase:al] is_a: FYPO:0001122 ! elongated vegetative cell intersection_of: FYPO:0000017 ! elongated cell intersection_of: exists_during GO:0071479 ! cellular response to ionizing radiation intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: exists_during GO:0071479 ! cellular response to ionizing radiation relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) created_by: midori creation_date: 2014-07-01T16:27:33Z [Term] id: FYPO:0003489 name: abnormal mitotic cell cycle regulation during cellular response to ionizing radiation def: "A cellular response phenotype observed in the vegetative growth phase of the life cycle in which the regulation of the mitotic cell cycle in response to ionizing radiation is abnormal. Normally, cell cycle progression is slowed or arrested transiently following exposure to ionizing radiation. The most common abnormality is for the cell cycle to progress as in the absence of ionizing radiation." [PomBase:mah] synonym: "abnormal cell cycle regulation during cellular response to ionizing radiation" EXACT [PomBase:mah] synonym: "abnormal mitotic cell cycle delay following ionizing radiation" EXACT [PomBase:al] synonym: "abnormal mitotic cell cycle regulation during cellular response to IR" EXACT [PomBase:mah] synonym: "abnormal mitotic cell cycle regulation in response to ionizing radiation" EXACT [PomBase:mah] is_a: FYPO:0000148 ! abnormal regulation of mitotic cell cycle is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0071479 ! cellular response to ionizing radiation intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0007346 ! regulation of mitotic cell cycle intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0071479 ! cellular response to ionizing radiation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0007346 ! regulation of mitotic cell cycle relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-07-01T16:28:40Z [Term] id: FYPO:0003490 name: increased duration of DNA damage checkpoint during cellular response to ionizing radiation def: "A cell cycle checkpoint phenotype in which the duration of cell cycle arrest or delay due to regulation by any DNA damage checkpoint is greater than in wild type during a cellular response to ionizing radiation." [PomBase:mah] synonym: "delayed DNA damage checkpoint deactivation during cellular response to ionizing radiation" EXACT [PomBase:mah] synonym: "increased duration of DNA damage checkpoint during cellular response to IR" EXACT [PomBase:mah] synonym: "prolonged DNA damage checkpoint during cellular response to ionizing radiation" EXACT [PomBase:mah] is_a: FYPO:0002341 ! increased duration of DNA damage checkpoint intersection_of: PATO:0000498 ! increased duration intersection_of: during GO:0071479 ! cellular response to ionizing radiation intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000077 ! DNA damage checkpoint relationship: during GO:0071479 ! cellular response to ionizing radiation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000077 ! DNA damage checkpoint created_by: midori creation_date: 2014-07-01T16:30:58Z [Term] id: FYPO:0003491 name: sensitive to UV during mitotic G1 phase def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to ultraviolet light during G1 phase of the mitotic cell cycle." [PomBase:mah] synonym: "hypersensitive to UV during mitotic G1 phase" EXACT [PomBase:mah] synonym: "increased sensitivity to UV irradiation during mitotic G1 phase" EXACT [PomBase:vw] synonym: "sensitive to ultraviolet light during mitotic G1 phase" EXACT [PomBase:mah] synonym: "sensitive to UV during G1 phase during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000268 ! sensitive to UV during vegetative growth created_by: midori creation_date: 2014-07-01T16:33:46Z [Term] id: FYPO:0003492 name: resistance to beta-glucanase def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of beta-glucanase, any enzyme that degrades cell wall polysaccharides by hydrolyzing beta-glucan linkages, than normal." [PomBase:mah] synonym: "resistance to beta-glucanase during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to beta-glucanase during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to beta-glucanase" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth created_by: midori creation_date: 2014-07-01T16:35:58Z [Term] id: FYPO:0003493 name: resistance to hypothemycin def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of hypothemycin than normal." [PomBase:mah] synonym: "resistance to hypothemycin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to hypothemycin during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to hypothemycin" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:83275 ! hypothemycin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:83275 ! hypothemycin created_by: midori creation_date: 2014-07-01T16:43:41Z [Term] id: FYPO:0003494 name: sensitive to L-azetidine-2-carboxylic acid def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to L-azetidine-2-carboxylic acid. Cells stop growing (and may die) at a concentration of L-azetidine-2-carboxylic acid that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to L-azetidine-2-carboxylic acid" EXACT [PomBase:mah] synonym: "sensitive to (S)-azetidine-2-carboxylic acid" EXACT [CHEBI:6198, PomBase:mah] synonym: "sensitive to L-azetidine-2-carboxylic acid during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to L-azetidine-2-carboxylic acid during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:6198 ! (S)-azetidine-2-carboxylic acid relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:6198 ! (S)-azetidine-2-carboxylic acid created_by: midori creation_date: 2014-07-01T16:48:29Z [Term] id: FYPO:0003495 name: abnormal azetidine-2-carboxylic acid acetyltransferase activity def: "A molecular function phenotype in which the observed rate of azetidine-2-carboxylic acid acetyltransferase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0046941 ! azetidine-2-carboxylic acid acetyltransferase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0046941 ! azetidine-2-carboxylic acid acetyltransferase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-07-01T16:51:16Z [Term] id: FYPO:0003496 name: abolished azetidine-2-carboxylic acid acetyltransferase activity def: "A molecular function phenotype in which azetidine-2-carboxylic acid acetyltransferase activity is absent." [PomBase:mah] synonym: "azetidine-2-carboxylic acid acetyltransferase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0003495 ! abnormal azetidine-2-carboxylic acid acetyltransferase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0046941 ! azetidine-2-carboxylic acid acetyltransferase activity relationship: towards GO:0046941 ! azetidine-2-carboxylic acid acetyltransferase activity created_by: midori creation_date: 2014-07-01T16:51:26Z [Term] id: FYPO:0003497 name: increased azetidine-2-carboxylic acid acetyltransferase activity def: "A molecular function phenotype in which the observed rate of azetidine-2-carboxylic acid acetyltransferase activity is increased." [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0003495 ! abnormal azetidine-2-carboxylic acid acetyltransferase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0046941 ! azetidine-2-carboxylic acid acetyltransferase activity relationship: inheres_in GO:0046941 ! azetidine-2-carboxylic acid acetyltransferase activity created_by: midori creation_date: 2014-07-01T16:51:50Z [Term] id: FYPO:0003498 name: premature mitotic DNA replication initiation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the initiation of nuclear DNA replication begins earlier than normal." [PMID:22970243, PomBase:mah] synonym: "advanced mitotic DNA replication initiation" EXACT [PomBase:mah] synonym: "premature DNA replication initiation during mitotic cell cycle" EXACT [PomBase:mah] synonym: "premature DNA replication initiation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001344 ! abnormal mitotic DNA replication initiation is_a: PATO:0000694 ! premature intersection_of: PATO:0000694 ! premature intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902975 ! mitotic DNA replication initiation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902975 ! mitotic DNA replication initiation created_by: midori creation_date: 2014-07-01T16:56:35Z [Term] id: FYPO:0003499 name: increased rate of pre-replicative complex assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the rate, or speed, of pre-replicative complex assembly is increased." [PMID:22970243, PomBase:mah] synonym: "increased rate of MCM complex loading" NARROW [PMID:22970243, PomBase:vw] synonym: "increased rate of pre-RC assembly" EXACT [PomBase:mah] synonym: "increased rate of pre-replicative complex assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased rate of pre-replicative complex assembly during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000773 ! abnormal pre-replicative complex assembly is_a: PATO:0000912 ! increased rate intersection_of: PATO:0000912 ! increased rate intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006267 ! pre-replicative complex assembly involved in nuclear cell cycle DNA replication relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006267 ! pre-replicative complex assembly involved in nuclear cell cycle DNA replication created_by: midori creation_date: 2014-07-01T17:00:14Z [Term] id: FYPO:0003500 name: viable branched, elongated, multiseptate vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is viable, forms one or more branches near a septum, is elongated, and has more than one septum." [PomBase:mah] synonym: "viable branched, elongated, multiseptate cell during vegetative growth" EXACT [PomBase:mah] synonym: "viable branched, elongated, multiseptate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "viable branched, long, multiseptate cell" EXACT [PomBase:vw] is_a: FYPO:0000134 ! branched, elongated, multiseptate cell is_a: FYPO:0001496 ! viable elongated multiseptate vegetative cell is_a: FYPO:0002459 ! viable branched, elongated vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000015 ! branched vegetative cell intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000118 ! multiseptate vegetative cell intersection_of: has_part FYPO:0001491 ! viable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000015 ! branched vegetative cell relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000118 ! multiseptate vegetative cell relationship: has_part FYPO:0001491 ! viable vegetative cell created_by: midori creation_date: 2014-07-01T17:16:27Z [Term] id: FYPO:0003501 name: inviable aseptate mononucleate vegetative cell, normal cell length def: "A cell phenotype in which a cell is inviable, is normal length, and contains one nucleus and no septum." [PomBase:mah] synonym: "inviable aseptate mononucleate cell, normal cell length, during vegetative growth" EXACT [PomBase:mah] synonym: "inviable aseptate mononucleate vegetative cell, normal cell length during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable mononucleate aseptate vegetative cell, normal cell length" EXACT [PomBase:mah] synonym: "inviable unseptated mononucleate vegetative cell with normal cell length" EXACT [PomBase:mah] is_a: FYPO:0003763 ! inviable aseptate mononucleate vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000060 ! mononucleate vegetative cell intersection_of: has_part FYPO:0000949 ! aseptate intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0003503 ! normal vegetative cell length relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000060 ! mononucleate vegetative cell relationship: has_part FYPO:0000949 ! aseptate relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0003503 ! normal vegetative cell length created_by: midori creation_date: 2014-07-01T17:19:22Z [Term] id: FYPO:0003502 name: abolished cell population growth on raffinose carbon source def: "A vegetative cell population growth phenotype in which a cell population does not grow in a medium containing raffinose as the carbon source." [PomBase:mah] comment: Use this term for a population of cells that does not grow with raffinose as the carbon source, but does grow using a different carbon source (a cell population that does not grow on any media would be considered inviable). Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "abolished growth on raffinose carbon source" BROAD [PomBase:mah] synonym: "abolished raffinose utilization" RELATED [PomBase:mah, PomBase:vw] synonym: "abolished vegetative cell population growth on raffinose carbon source" EXACT [PomBase:mah] synonym: "cell population growth on raffinose carbon source abolished" EXACT [PomBase:mah] is_a: FYPO:0001162 ! decreased cell population growth on raffinose carbon source is_a: FYPO:0001575 ! abolished vegetative cell population growth created_by: midori creation_date: 2014-07-01T17:25:43Z [Term] id: FYPO:0003503 name: normal vegetative cell length def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell has a normal length." [PomBase:mah] synonym: "normal cell length during vegetative growth" EXACT [PomBase:mah] synonym: "normal vegetative cell length during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001124 ! normal vegetative cell size is_a: PATO:0000122 ! length intersection_of: PATO:0000122 ! length intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-07-01T17:33:44Z [Term] id: FYPO:0003504 name: increased protein level in plasma membrane def: "A cell phenotype in which the amount of protein measured in the plasma membrane is higher than normal when the cell is in the vegetative growth phase of the life cycle. Total protein or a specific protein may be affected." [PomBase:mah] comment: An increased level of a protein in the plasma membrane may result from increased protein transport to the membrane ('increased protein localization to plasma membrane FYPO:0002127), decreased endocytosis from the membrane ('abolished endocytosis' FYPO:0000421 or 'decreased endocytosis' FYPO:0000422), or both. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased plasma membrane protein level during vegetative growth" EXACT [PomBase:mah] synonym: "increased protein level in cell membrane during vegetative growth" EXACT [GO:0005886] synonym: "increased protein level in plasma membrane during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein level in plasma membrane during vegetative growth" EXACT [PomBase:mah] synonym: "protein accumulation in plasma membrane" EXACT [PomBase:vw] is_a: FYPO:0001327 ! increased protein level during vegetative growth is_a: FYPO:0003278 ! abnormal plasma membrane intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005886 ! plasma membrane intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005886 ! plasma membrane relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2014-07-08T13:56:41Z [Term] id: FYPO:0003505 name: abolished glutathione gamma-glutamylcysteinyltransferase activity def: "A molecular function phenotype in which glutathione gamma-glutamylcysteinyltransferase activity is absent." [PomBase:mah] synonym: "glutathione gamma-glutamylcysteinyltransferase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0000754 ! abnormal glutathione gamma-glutamylcysteinyltransferase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0016756 ! glutathione gamma-glutamylcysteinyltransferase activity relationship: towards GO:0016756 ! glutathione gamma-glutamylcysteinyltransferase activity created_by: midori creation_date: 2014-07-08T14:16:15Z [Term] id: FYPO:0003506 name: normal growth on copper def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing copper ions." [PomBase:mah] synonym: "normal cell population growth in presence of copper" EXACT [PomBase:mah] synonym: "normal cell population growth on copper" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cell population growth on copper ion" EXACT [PomBase:mah] synonym: "normal cellular response to copper" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on copper" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:23378 ! copper cation relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:23378 ! copper cation created_by: midori creation_date: 2014-07-08T14:18:40Z [Term] id: FYPO:0003507 name: normal growth on zinc def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing zinc ions." [PomBase:mah] synonym: "normal cell population growth in presence of zinc" EXACT [PomBase:mah] synonym: "normal cell population growth on zinc" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cell population growth on zinc ion" EXACT [PomBase:mah] synonym: "normal cellular response to zinc" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on zinc" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:27365 ! zinc ion relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:27365 ! zinc ion created_by: midori creation_date: 2014-07-08T14:25:47Z [Term] id: FYPO:0003508 name: normal growth on mercury def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing mercury ions." [PomBase:mah] synonym: "normal cell population growth in presence of mercury" EXACT [PomBase:mah] synonym: "normal cell population growth on mercury" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cell population growth on mercury ion" EXACT [PomBase:mah] synonym: "normal cellular response to mercury" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on mercury" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:25197 ! mercury cation relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:25197 ! mercury cation created_by: midori creation_date: 2014-07-08T14:26:47Z [Term] id: FYPO:0003509 name: normal growth on selenite ion def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing selenite ions." [PomBase:mah] synonym: "normal cell population growth in presence of selenite ion" EXACT [PomBase:mah] synonym: "normal cell population growth on selenite ion" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to selenite ion" RELATED [PomBase:al, PomBase:mah] synonym: "normal growth on selenite" EXACT [PomBase:mah] synonym: "normal vegetative cell population growth on selenite ion" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:18212 ! selenite(2-) relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:18212 ! selenite(2-) created_by: midori creation_date: 2014-07-08T14:27:40Z [Term] id: FYPO:0003510 name: normal growth on silver def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing silver ions." [PomBase:mah] synonym: "normal cell population growth in presence of silver" EXACT [PomBase:mah] synonym: "normal cell population growth on silver" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cell population growth on silver ion" EXACT [PomBase:mah] synonym: "normal cellular response to silver" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on silver" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:60253 ! silver cation relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:60253 ! silver cation created_by: midori creation_date: 2014-07-08T14:28:44Z [Term] id: FYPO:0003511 name: L-ergothioneine absent from cell def: "A cell phenotype in which the amount of L-ergothioneine measured in a cell is too low to detect." [PomBase:mah] is_a: FYPO:0001208 ! substance absent from cell during vegetative growth is_a: FYPO:0003521 ! decreased cellular L-ergothioneine level intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:4828 ! ergothioneine relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:4828 ! ergothioneine created_by: midori creation_date: 2014-07-08T14:33:51Z [Term] id: FYPO:0003512 name: hercynine absent from cell def: "A cell phenotype in which the amount of hercynine (N(alpha),N(alpha),N(alpha)-trimethyl-L-histidine) measured in a cell is too low to detect." [PomBase:mah] synonym: "N(alpha),N(alpha),N(alpha)-trimethyl-L-histidine absent from cell" EXACT [CHEBI:15781] is_a: FYPO:0001208 ! substance absent from cell during vegetative growth is_a: FYPO:0003985 ! decreased cellular amino acid level intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:15781 ! N(alpha),N(alpha),N(alpha)-trimethyl-L-histidine relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:15781 ! N(alpha),N(alpha),N(alpha)-trimethyl-L-histidine created_by: midori creation_date: 2014-07-08T14:39:07Z [Term] id: FYPO:0003513 name: hercynylcysteine sulfoxide absent from cell def: "A cell phenotype in which the amount of hercynylcysteine sulfoxide measured in a cell is too low to detect." [PomBase:mah] synonym: "hercynylcysteine sulphoxide absent from cell" EXACT [PomBase:mah] is_a: FYPO:0001208 ! substance absent from cell during vegetative growth intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:79057 ! hercynylcysteine sulfoxide relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:79057 ! hercynylcysteine sulfoxide created_by: midori creation_date: 2014-07-08T14:40:26Z [Term] id: FYPO:0003514 name: hercynylselenocysteine absent from cell def: "A cell phenotype in which the amount of hercynylselenocysteine measured in a cell is too low to detect." [PomBase:mah] is_a: FYPO:0001208 ! substance absent from cell during vegetative growth intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:79070 ! hercynylselenocysteine relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:79070 ! hercynylselenocysteine created_by: midori creation_date: 2014-07-08T14:41:09Z [Term] id: FYPO:0003515 name: L-selenoneine absent from cell def: "A cell phenotype in which the amount of L-selenoneine measured in a cell is too low to detect." [PomBase:mah] is_a: FYPO:0001208 ! substance absent from cell during vegetative growth intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:79071 ! selenoneine relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:79071 ! selenoneine created_by: midori creation_date: 2014-07-08T14:41:39Z [Term] id: FYPO:0003516 name: increased cellular L-ergothioneine level during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-ergothioneine measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular L-ergothioneine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased L-ergothioneine level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:4828 ! ergothioneine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:4828 ! ergothioneine created_by: midori creation_date: 2014-07-08T14:42:37Z [Term] id: FYPO:0003517 name: increased cellular L-selenoneine level during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-selenoneine measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular L-selenoneine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased L-selenoneine level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:79071 ! selenoneine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:79071 ! selenoneine created_by: midori creation_date: 2014-07-08T14:43:51Z [Term] id: FYPO:0003518 name: increased cellular hercynine level during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of hercynine (N(alpha),N(alpha),N(alpha)-trimethyl-L-histidine) measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular hercynine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular N(alpha),N(alpha),N(alpha)-trimethyl-L-histidine level" EXACT [CHEBI:15781] synonym: "increased hercynine level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003986 ! increased cellular amino acid level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:15781 ! N(alpha),N(alpha),N(alpha)-trimethyl-L-histidine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:15781 ! N(alpha),N(alpha),N(alpha)-trimethyl-L-histidine created_by: midori creation_date: 2014-07-08T14:44:20Z [Term] id: FYPO:0003519 name: increased cellular hercynylcysteine sulfoxide level during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of hercynylcysteine sulfoxide measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular hercynylcysteine sulfoxide level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular hercynylcysteine sulphoxide level during vegetative growth" EXACT [PomBase:mah] synonym: "increased hercynylcysteine sulfoxide level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth is_a: FYPO:0003522 ! increased cellular hercynylcysteine sulfoxide level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:79057 ! hercynylcysteine sulfoxide relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:79057 ! hercynylcysteine sulfoxide created_by: midori creation_date: 2014-07-08T14:44:54Z [Term] id: FYPO:0003520 name: increased cellular hercynylselenocysteine level during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of hercynylselenocysteine measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular hercynylselenocysteine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased hercynylselenocysteine level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth is_a: FYPO:0003523 ! increased cellular hercynylselenocysteine level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:79070 ! hercynylselenocysteine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:79070 ! hercynylselenocysteine created_by: midori creation_date: 2014-07-08T14:45:15Z [Term] id: FYPO:0003521 name: decreased cellular L-ergothioneine level def: "A cell phenotype in which the amount of L-ergothioneine measured in a cell is lower than normal." [PomBase:mah] synonym: "decreased cellular L-ergothioneine accumulation" RELATED [PomBase:mah] synonym: "decreased L-ergothioneine level" EXACT [PomBase:mah] synonym: "reduced cellular L-ergothioneine level" EXACT [PomBase:mah] is_a: FYPO:0000991 ! decreased level of substance in cell intersection_of: PATO:0001163 ! decreased concentration intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:4828 ! ergothioneine relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:4828 ! ergothioneine created_by: midori creation_date: 2014-07-08T14:47:20Z [Term] id: FYPO:0003522 name: increased cellular hercynylcysteine sulfoxide level def: "A cell phenotype in which the amount of hercynylcysteine sulfoxide measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular hercynylcysteine sulphoxide level" EXACT [PomBase:mah] synonym: "increased hercynylcysteine sulfoxide level" EXACT [PomBase:mah] is_a: FYPO:0000990 ! increased level of substance in cell intersection_of: PATO:0001162 ! increased concentration intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:79057 ! hercynylcysteine sulfoxide relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:79057 ! hercynylcysteine sulfoxide created_by: midori creation_date: 2014-07-08T14:54:15Z [Term] id: FYPO:0003523 name: increased cellular hercynylselenocysteine level def: "A cell phenotype in which the amount of hercynylselenocysteine measured in a cell is higher than normal." [PomBase:mah] synonym: "increased hercynylselenocysteine level" EXACT [PomBase:mah] is_a: FYPO:0000990 ! increased level of substance in cell intersection_of: PATO:0001162 ! increased concentration intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:79070 ! hercynylselenocysteine relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:79070 ! hercynylselenocysteine created_by: midori creation_date: 2014-07-08T14:58:41Z [Term] id: FYPO:0003524 name: abnormal actin cytoskeleton organization at cell tip def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which actin cytoskeleton organization is abnormal at one or both cell tips." [GO:0030036, PMID:24954052, PomBase:mah] comment: Consider annotating to 'abnormal actin cytoskeleton' (FYPO:0002398), but note that an abnormal actin cytoskeleton organization process may, but does not necessarily, result in a physically abnormal actin cytoskeleton. synonym: "abnormal actin cytoskeleton organisation at cell tip" EXACT [PomBase:mah] synonym: "abnormal actin cytoskeleton organization at cell end" EXACT [PomBase:mah] synonym: "abnormal actin cytoskeleton organization at cell tip during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal actin cytoskeleton organization at cell tip during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000801 ! abnormal actin cytoskeleton organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0030036 ! actin cytoskeleton organization intersection_of: occurs_in GO:0051286 ! cell tip intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0030036 ! actin cytoskeleton organization relationship: occurs_in GO:0051286 ! cell tip relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-07-08T15:10:06Z [Term] id: FYPO:0003525 name: increased actin filament polymerization at cell tip def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the addition of actin monomers to a filament occurs to a greater extent than normal at one or both cell tips." [GO:0030041, PMID:24954052, PomBase:mah] synonym: "increased actin filament polymerisation at cell tip" RELATED [PomBase:mah] synonym: "increased actin filament polymerization at cell end" EXACT [PomBase:mah] synonym: "increased actin filament polymerization at cell tip during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased actin filament polymerization at cell tip during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003524 ! abnormal actin cytoskeleton organization at cell tip is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0030041 ! actin filament polymerization intersection_of: occurs_in GO:0051286 ! cell tip relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0030041 ! actin filament polymerization relationship: occurs_in GO:0051286 ! cell tip created_by: midori creation_date: 2014-07-08T15:12:02Z [Term] id: FYPO:0003526 name: decreased actin filament-based movement def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which actin filament-based movement is decreased. Actin filament-based movement is the movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GO:0030048, PMID:24954052, PomBase:mah] synonym: "decreased actin filament-based movement during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased actin filament-based movement during vegetative growth" EXACT [PomBase:mah] synonym: "reduced actin filament-based movement" EXACT [PomBase:mah] is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0030048 ! actin filament-based movement relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0030048 ! actin filament-based movement created_by: midori creation_date: 2014-07-08T15:15:23Z [Term] id: FYPO:0003527 name: protein mislocalized to cell tip def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a protein that is not normally found at the cell tip is observed there." [PomBase:mah] comment: Note that this term can be used to annotate any case where a protein is found at the cell tip in a mutant, but not in wild type. In some cases, there may be enough additional information to annotate to 'abnormal protein localization' (FYPO:0000443) or one of its descendants. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "ectopic protein localization to cell tip" EXACT [PomBase:vw] synonym: "protein mislocalised to cell tip" EXACT [PomBase:mah] synonym: "protein mislocalised to cell tip during vegetative growth" EXACT [PomBase:mah] synonym: "protein mislocalized to cell tip during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein mislocalized to cell tip during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000782 ! mislocalized protein during vegetative growth intersection_of: PATO:0000628 ! mislocalised intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CHEBI:36080 ! protein intersection_of: towards GO:0051286 ! cell tip relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CHEBI:36080 ! protein relationship: towards GO:0051286 ! cell tip created_by: midori creation_date: 2014-07-08T15:17:32Z [Term] id: FYPO:0003528 name: protein mislocalized to actomyosin contractile ring def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a protein that is not normally found at the actomyosin contractile ring is observed there." [PomBase:mah] comment: Note that this term can be used to annotate any case where a protein is found at the contractile ring in a mutant, but not in wild type. In some cases, there may be enough additional information to annotate to 'abnormal protein localization' (FYPO:0000443) or one of its descendants. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "ectopic protein localization to actomyosin contractile ring" EXACT [PomBase:vw] synonym: "protein mislocalised to actomyosin contractile ring" EXACT [PomBase:mah] synonym: "protein mislocalised to actomyosin contractile ring during vegetative growth" EXACT [PomBase:mah] synonym: "protein mislocalized to actomyosin contractile ring during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein mislocalized to actomyosin contractile ring during vegetative growth" EXACT [PomBase:mah] synonym: "protein mislocalized to cytokinetic contractile ring" EXACT [PomBase:vw] synonym: "protein mislocalized to mitotic contractile ring" EXACT [PomBase:vw] is_a: FYPO:0000782 ! mislocalized protein during vegetative growth intersection_of: PATO:0000628 ! mislocalised intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CHEBI:36080 ! protein intersection_of: towards GO:0005826 ! actomyosin contractile ring relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CHEBI:36080 ! protein relationship: towards GO:0005826 ! actomyosin contractile ring created_by: midori creation_date: 2014-07-08T15:24:40Z [Term] id: FYPO:0003529 name: inviable after spore germination, multiple cell divisions, cell cycle arrest in mitotic interphase, elongated cells def: "A phenotype in which a spore germinates to produce a cell that enters the cell cycle and undergoes two or more rounds of cell division, but then becomes elongated and undergoes cell cycle arrest in interphase of the mitotic cell cycle, and eventually dies." [PomBase:mah] synonym: "inviable after spore germination, multiple cell divisions, elongated aseptate cell" EXACT [PMID:15116432, PomBase:al, PomBase:mah] synonym: "inviable after spore germination, multiple cell divisions, elongated cell arrested at interphase" EXACT [PomBase:vw] synonym: "inviable germinated spore, multiple cell divisions, cell cycle arrest in mitotic interphase, elongated cells" EXACT [PomBase:mah] is_a: FYPO:0002262 ! inviable after spore germination, multiple cell divisions, elongated cell created_by: midori creation_date: 2014-07-08T16:53:27Z [Term] id: FYPO:0003530 name: normal S-phase DNA damage checkpoint def: "A cell cycle checkpoint phenotype in which the S-phase DNA damage checkpoint (also known as the intra-S phase DNA damage checkpoint) is normal (i.e. indistinguishable from wild type). The S phase DNA damage checkpoint slows progression through S phase in response to DNA damage. In a mutant, the checkpoint may fail to arrest or delay cell cycle progression under appropriate conditions, or the incidence or duration of arrest or delay may differ from wild type under any specified set of conditions." [PomBase:mah] synonym: "normal intra-S DNA damage checkpoint" EXACT [PomBase:mah] synonym: "normal S-phase DNA damage checkpoint activation" EXACT [PomBase:mah] synonym: "normal S-phase DNA damage checkpoint during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal S-phase DNA damage checkpoint during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001705 ! normal mitotic DNA damage checkpoint intersection_of: PATO:0000001 ! quality intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0031573 ! intra-S DNA damage checkpoint intersection_of: qualifier PATO:0000461 ! normal relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0031573 ! intra-S DNA damage checkpoint relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-07-09T14:22:09Z [Term] id: FYPO:0003531 name: normal peroxisome size def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which peroxisome size is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal peroxisome size during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal peroxisome size during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001313 ! normal subcellular component during vegetative growth is_a: PATO:0000117 ! size intersection_of: PATO:0000117 ! size intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005777 ! peroxisome intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005777 ! peroxisome relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-07-09T14:39:27Z [Term] id: FYPO:0003532 name: increased monopolar index def: "A cell population phenotype in which the monopolar index is higher than normal. The monopolar index is the proportion of the population undergoing monopolar growth at any given time." [PMID:20501954, PomBase:al, PomBase:mah] synonym: "increased frequency of monopolar growth polarity" RELATED [PMID:20501954] synonym: "increased number of cells undergoing monopolar growth" EXACT [PomBase:mah] is_a: FYPO:0000003 ! cell population phenotype is_a: FYPO:0001985 ! abnormal phenotype created_by: midori creation_date: 2014-07-09T15:01:21Z [Term] id: FYPO:0003533 name: increased bipolar index def: "A cell population phenotype in which the bipolar index is higher than normal. The bipolar index is the proportion of the population undergoing bipolar growth at any given time." [PMID:20501954, PomBase:al, PomBase:mah] synonym: "increased frequency of bipolar growth polarity" RELATED [PMID:20501954] synonym: "increased number of cells undergoing bipolar growth" EXACT [PomBase:mah] is_a: FYPO:0000003 ! cell population phenotype is_a: FYPO:0001985 ! abnormal phenotype created_by: midori creation_date: 2014-07-09T15:03:49Z [Term] id: FYPO:0003534 name: decreased monopolar index def: "A cell population phenotype in which the monopolar index is lower than normal. The monopolar index is the proportion of the population undergoing monopolar growth at any given time." [PMID:20501954, PomBase:al, PomBase:mah] synonym: "decreased frequency of monopolar growth polarity" RELATED [PMID:20501954] synonym: "decreased number of cells undergoing monopolar growth" EXACT [PomBase:mah] synonym: "reduced monopolar index" EXACT [PomBase:mah] is_a: FYPO:0000003 ! cell population phenotype is_a: FYPO:0001985 ! abnormal phenotype created_by: midori creation_date: 2014-07-09T15:24:42Z [Term] id: FYPO:0003535 name: decreased bipolar index def: "A cell population phenotype in which the bipolar index is lower than normal. The bipolar index is the proportion of the population undergoing bipolar growth at any given time." [PMID:20501954, PomBase:al, PomBase:mah] synonym: "decreased frequency of bipolar growth polarity" RELATED [PMID:20501954] synonym: "decreased number of cells undergoing bipolar growth" EXACT [PomBase:mah] synonym: "reduced bipolar index" EXACT [PomBase:mah] is_a: FYPO:0000003 ! cell population phenotype is_a: FYPO:0001985 ! abnormal phenotype created_by: midori creation_date: 2014-07-09T15:25:04Z [Term] id: FYPO:0003536 name: increased septation index in stationary phase def: "A cell population phenotype in which the septation index is higher than normal in a population in stationary phase. The septation index is the proportion of the population undergoing septation at any given time." [PomBase:mah, PomBase:vw] synonym: "increased septation in stationary phase" RELATED [PomBase:mah] synonym: "increased septation index during stationary phase" EXACT [PomBase:mah] synonym: "septated in stationary phase" RELATED [PomBase:vw] is_a: FYPO:0000650 ! increased septation index created_by: midori creation_date: 2014-07-15T10:50:15Z [Term] id: FYPO:0003537 name: decreased rate of premeiotic DNA replication def: "A cellular process phenotype in which the rate, or speed, of premeiotic DNA replication is decreased." [PomBase:mah] synonym: "reduced rate of premeiotic DNA replication" EXACT [PomBase:mah] is_a: FYPO:0001981 ! decreased rate of DNA replication intersection_of: PATO:0000911 ! decreased rate intersection_of: inheres_in GO:0006279 ! premeiotic DNA replication relationship: inheres_in GO:0006279 ! premeiotic DNA replication created_by: midori creation_date: 2014-07-15T10:58:05Z [Term] id: FYPO:0003538 name: premature meiosis I def: "A cellular process phenotype in which the first meiotic nuclear division occurs prematurely." [PomBase:mah] synonym: "advanced meiosis I" EXACT [PomBase:mah] synonym: "premature first meiotic nuclear division" EXACT [PomBase:mah] is_a: FYPO:0000479 ! premature meiosis intersection_of: PATO:0000694 ! premature intersection_of: inheres_in GO:0007127 ! meiosis I relationship: inheres_in GO:0007127 ! meiosis I created_by: midori creation_date: 2014-07-15T10:59:35Z [Term] id: FYPO:0003539 name: decreased global homologous chromosome pairing def: "A cellular process phenotype in which homologous chromosome pairing during meiosis (synapsis) is decreased (i.e. occurs to a lower extent) over the entire length of the chromosomes." [PomBase:mah] synonym: "decreased generalised homologous chromosome pairing" EXACT [PATO:0002403] synonym: "decreased global homologous chromosome pairing at meiosis" EXACT [GO:0007129] synonym: "decreased global synapsis" EXACT [GO:0007129] synonym: "globally decreased homologous chromosome pairing" EXACT [PomBase:mah] synonym: "reduced global homologous chromosome pairing" EXACT [PomBase:mah] is_a: FYPO:0003024 ! abnormal homologous chromosome pairing created_by: midori creation_date: 2014-07-15T12:46:12Z [Term] id: FYPO:0003540 name: decreased regional homologous chromosome pairing def: "A cellular process phenotype in which homologous chromosome pairing during meiosis (synapsis) is decreased (i.e. occurs to a lower extent) in one or more specific regions of the chromosomes." [PomBase:mah] synonym: "decreased localised homologous chromosome pairing" EXACT [PATO:0000627] synonym: "decreased regional homologous chromosome pairing at meiosis" EXACT [GO:0007129] synonym: "decreased regional synapsis" EXACT [GO:0007129] synonym: "reduced regional homologous chromosome pairing" EXACT [PomBase:mah] synonym: "regionally decreased homologous chromosome pairing" EXACT [PomBase:mah] is_a: FYPO:0003024 ! abnormal homologous chromosome pairing created_by: midori creation_date: 2014-07-15T12:54:18Z [Term] id: FYPO:0003541 name: normal protein localization to meiotic spindle pole body def: "A cell phenotype in which the localization of a protein to the meiotic spindle pole body is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: Encompasses both presence of proteins not normally found at the spindle pole body and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to meiotic spindle pole body" EXACT [PomBase:mah] synonym: "normal protein localization to meiotic SPB" EXACT [PomBase:mah] is_a: FYPO:0001836 ! normal protein localization to spindle pole body is_a: FYPO:0003790 ! normal protein localization during meiosis intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:1902441 ! protein localization to meiotic spindle pole body intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:1902441 ! protein localization to meiotic spindle pole body relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-07-15T13:05:03Z [Term] id: FYPO:0003542 name: abolished protein localization to meiotic spindle pole body def: "A cell phenotype in which the localization of a protein to the meiotic spindle pole body is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. Use this term for cells in which in which the re-accumulation of some spindle pole body components does not occur at the onset of meiosis I. synonym: "abolished protein localisation to meiotic spindle pole body" EXACT [PomBase:mah] synonym: "abolished protein localization to meiotic SPB" EXACT [PomBase:mah] synonym: "protein localization to meiotic spindle pole body abolished" EXACT [PomBase:mah] synonym: "reduced protein localization to meiotic spindle pole body" EXACT [PomBase:mah] is_a: FYPO:0002771 ! abnormal protein localization to meiotic spindle pole body is_a: FYPO:0004091 ! abolished protein localization to microtubule cytoskeleton intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:1902441 ! protein localization to meiotic spindle pole body relationship: towards GO:1902441 ! protein localization to meiotic spindle pole body created_by: midori creation_date: 2014-07-15T13:06:08Z [Term] id: FYPO:0003543 name: increased number of double-strand break sites def: "A cell phenotype in which the number of sites of double-strand breaks in DNA is greater than normal." [PomBase:mah] comment: Because Rad22 often accumulates at double-strand breaks, consider also annotating to 'increased number of Rad22 foci' (FYPO:0000972). synonym: "accumulation of DNA damage foci" RELATED [PomBase:mah] synonym: "accumulation of double-strand break sites" EXACT [PomBase:mah] synonym: "increased number of DNA damage foci" RELATED [PomBase:mah] is_a: FYPO:0003546 ! increased DNA damage is_a: PATO:0002002 ! has extra parts of type intersection_of: PATO:0002002 ! has extra parts of type intersection_of: towards GO:0035861 ! site of double-strand break relationship: towards GO:0035861 ! site of double-strand break created_by: midori creation_date: 2014-07-15T13:31:59Z [Term] id: FYPO:0003544 name: increased number of double-strand break sites during meiotic cell cycle def: "A cell phenotype in which the number of sites of double-strand breaks in DNA is greater than normal during a meiotic cell cycle." [PomBase:mah] comment: Because Rad22 often accumulates at double-strand breaks, consider also annotating to 'increased number of Rad22 foci' (FYPO:0000972). synonym: "accumulation of DNA damage foci during meiotic cell cycle" RELATED [PomBase:mah] synonym: "accumulation of double-strand break sites during meiotic cell cycle" EXACT [PomBase:mah] synonym: "increased number of DNA damage foci during meiotic cell cycle" RELATED [PomBase:mah] synonym: "increased number of double-strand break sites during meiosis" RELATED [PomBase:mah] synonym: "increased number of meiotic double-strand break sites" EXACT [PomBase:vw] synonym: "increased number of meiotic double-strand breaks" EXACT [PomBase:vw] is_a: FYPO:0003543 ! increased number of double-strand break sites intersection_of: PATO:0002002 ! has extra parts of type intersection_of: happens_during GO:0051321 ! meiotic cell cycle intersection_of: towards GO:0035861 ! site of double-strand break relationship: happens_during GO:0051321 ! meiotic cell cycle relationship: towards GO:0035861 ! site of double-strand break created_by: midori creation_date: 2014-07-15T13:33:04Z [Term] id: FYPO:0003545 name: increased duration of mitotic cell cycle DNA replication checkpoint def: "A cell cycle checkpoint phenotype in which the duration of mitotic cell cycle arrest or delay due to regulation by the DNA replication checkpoint is greater than normal. The DNA replication checkpoint normally prevents the initiation of mitosis until DNA replication is complete." [PomBase:mah] synonym: "increased duration of DNA replication checkpoint" BROAD [PomBase:mah] synonym: "increased duration of mitotic cell cycle DNA replication checkpoint activation" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "mitotic cell cycle DNA replication checkpoint activated" RELATED [PomBase:mah] synonym: "prolonged mitotic cell cycle DNA replication checkpoint" EXACT [PomBase:mah] is_a: FYPO:0000173 ! abnormal mitotic cell cycle DNA replication checkpoint is_a: PATO:0000498 ! increased duration intersection_of: PATO:0000498 ! increased duration intersection_of: inheres_in GO:0033314 ! mitotic DNA replication checkpoint relationship: inheres_in GO:0033314 ! mitotic DNA replication checkpoint created_by: midori creation_date: 2014-07-15T13:40:17Z [Term] id: FYPO:0003546 name: increased DNA damage def: "A cell phenotype in which the amount of DNA damage measured in a cell is greater than normal. The number, extent, or both of damage sites may be increased." [PomBase:mah] synonym: "increased number of DNA lesions" RELATED [PomBase:al] synonym: "increased spontaneous DNA lesions" RELATED [PomBase:vw] is_a: FYPO:0000136 ! cellular physical quality phenotype created_by: midori creation_date: 2014-07-15T13:46:05Z [Term] id: FYPO:0003547 name: increased DNA damage during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of DNA damage measured in a cell is greater than normal. The number, extent, or both of damage sites may be increased." [PomBase:mah] synonym: "increased DNA damage during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased number of DNA lesions during vegetative growth" RELATED [PomBase:al] synonym: "increased spontaneous DNA lesions during vegetative growth" RELATED [PomBase:vw] is_a: FYPO:0003546 ! increased DNA damage created_by: midori creation_date: 2014-07-15T13:58:24Z [Term] id: FYPO:0003548 name: abolished mitotic G1/S transition following nitrogen starvation-induced G1 phase arrest def: "A cell cycle phenotype in which the G1/S transition of the mitotic cell cycle does not occur after the cell has been arrested in G1 phase due to nitrogen starvation. The cell remains arrested in G1." [PMID:9366254, PomBase:mah] comment: A G1/S delay may indicate that a checkpoint, such as the cell size checkpoint or the G1/S DNA damage checkpoint, is activated. Checkpoint activation can be tested using checkpoint kinase mutants. synonym: "abolished cell cycle progression through mitotic G1/S phase transition following cell cycle arrest in mitotic G1 phase in response to nitrogen starvation" EXACT [PomBase:mah] synonym: "abolished mitotic G1 phase progression following nitrogen starvation-induced G1 phase arrest" RELATED [PomBase:mah] synonym: "mitotic cell cycle G1/S transition abolished following nitrogen starvation-induced G1 phase arrest" EXACT [PomBase:mah] synonym: "mitotic G1/S transition abolished after recovery from nitrogen starvation-induced G1 arrest" EXACT [PMID:8657126, PomBase:vw] is_a: FYPO:0000394 ! abnormal mitotic G1/S phase transition created_by: midori creation_date: 2014-07-15T14:10:19Z [Term] id: FYPO:0003549 name: abnormal protein localization during meiosis def: "A cell phenotype that affects the localization of a protein in a cell during one or both meiotic nuclear divisions. A protein may be observed in a place where it is not normally found, absent from a place where it is normally found, or both." [PomBase:mah] comment: We recommend using one of the more specific terms instead of annotating to this term directly, if possible. If this term is used, we recommend noting which protein(s) were used in the assay. synonym: "abnormal cellular protein localisation during meiosis" EXACT [PomBase:mah] synonym: "abnormal cellular protein localization during meiosis" EXACT [PomBase:mah] synonym: "abnormal protein localisation during meiosis" EXACT [PomBase:mah] synonym: "abnormal protein localization during meiotic nuclear division" EXACT [GO:0007126] is_a: FYPO:0004094 ! abnormal protein localization during meiotic cell cycle intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0007126 ! meiotic nuclear division intersection_of: inheres_in_part_of GO:0034613 ! cellular protein localization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0007126 ! meiotic nuclear division relationship: inheres_in_part_of GO:0034613 ! cellular protein localization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-07-17T09:54:27Z [Term] id: FYPO:0003550 name: decreased protein level during meiosis def: "A cell phenotype in which the amount of protein measured in a cell during one or both meiotic nuclear divisions is lower than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein accumulation during meiosis" RELATED [PomBase:mah] synonym: "decreased protein level during meiotic nuclear division" EXACT [GO:0007126] synonym: "reduced protein level during meiosis" EXACT [PomBase:mah] is_a: FYPO:0000835 ! decreased protein level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0007126 ! meiotic nuclear division intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0007126 ! meiotic nuclear division relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2014-07-17T10:26:58Z [Term] id: FYPO:0003551 name: abnormal RNA catabolic process def: "A cellular process phenotype in which an RNA catabolic process is abnormal." [GO:0006914, PomBase:mah] synonym: "abnormal RNA breakdown" EXACT [PomBase:mah] synonym: "abnormal RNA catabolism" EXACT [GO:0006401] synonym: "abnormal RNA degradation" EXACT [PomBase:mah] is_a: FYPO:0000292 ! nucleic acid metabolism phenotype is_a: FYPO:0000860 ! abnormal metabolic process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0006401 ! RNA catabolic process intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0006401 ! RNA catabolic process relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-07-17T10:43:12Z [Term] id: FYPO:0003552 name: decreased RNA catabolic process def: "A cellular process phenotype in which the occurrence of an RNA catabolic process is decreased." [PomBase:mah] synonym: "decreased RNA breakdown" EXACT [PomBase:mah] synonym: "decreased RNA catabolism" EXACT [GO:0006401] synonym: "decreased RNA degradation" EXACT [PomBase:mah] synonym: "reduced RNA catabolic process" EXACT [PomBase:mah] is_a: FYPO:0003551 ! abnormal RNA catabolic process is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0006401 ! RNA catabolic process relationship: has_output FYPO:0001890 ! increased RNA level relationship: inheres_in GO:0006401 ! RNA catabolic process created_by: midori creation_date: 2014-07-17T10:43:44Z [Term] id: FYPO:0003553 name: increased RNA catabolic process def: "A cellular process phenotype in which the occurrence of an RNA catabolic process is increased." [PomBase:mah] synonym: "increased RNA breakdown" EXACT [PomBase:mah] synonym: "increased RNA catabolism" EXACT [GO:0006401] synonym: "increased RNA degradation" EXACT [PomBase:mah] is_a: FYPO:0003551 ! abnormal RNA catabolic process is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0006401 ! RNA catabolic process relationship: has_output FYPO:0000826 ! decreased RNA level relationship: inheres_in GO:0006401 ! RNA catabolic process created_by: midori creation_date: 2014-07-17T10:43:48Z [Term] id: FYPO:0003554 name: increased degradation of middle meiotic gene RNA during late meiosis def: "A cellular process phenotype in which the occurrence of degradation of RNA transcribed from middle meiotic genes is increased during late meiosis." [PMID:20531409, PomBase:mah] synonym: "increased breakdown of middle meiotic gene RNA during late meiosis" EXACT [PomBase:mah] synonym: "increased catabolism of middle meiotic gene RNA during late meiosis" EXACT [PomBase:mah] is_a: FYPO:0003553 ! increased RNA catabolic process created_by: midori creation_date: 2014-07-17T10:48:30Z [Term] id: FYPO:0003555 name: normal chromatin silencing at telomere def: "A transcription regulation phenotype observed in the vegetative growth phase of the life cycle in which chromatin silencing at the telomeres is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal chromatin silencing at telomere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal chromatin silencing at telomere during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002335 ! normal chromatin silencing intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006348 ! chromatin silencing at telomere intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006348 ! chromatin silencing at telomere relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-07-17T10:53:27Z [Term] id: FYPO:0003556 name: abnormal transcription termination def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the termination of RNA transcription from a DNA template is abnormal." [GO:0006353, PomBase:mah] synonym: "abnormal DNA-templated transcription, termination" EXACT [GO:0006353] synonym: "abnormal termination of transcription" EXACT [PomBase:al] synonym: "abnormal transcription termination during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal transcription termination during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000294 ! RNA metabolism phenotype is_a: FYPO:0001337 ! localization phenotype during vegetative growth is_a: FYPO:0001363 ! abnormal metabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006353 ! DNA-templated transcription, termination intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006353 ! DNA-templated transcription, termination relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-07-17T11:10:03Z [Term] id: FYPO:0003557 name: increased antisense RNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of antisense RNA measured in a cell is higher than normal. Antisense RNA is transcribed from the coding, rather than the template, strand of DNA." [PomBase:mah, SO:0000644] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased antisense RNA accumulation" RELATED [PomBase:mah] synonym: "increased antisense RNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased antisense RNA level during vegetative growth" EXACT [PomBase:mah] synonym: "increased antisense RNA transcript level" EXACT [PomBase:vw] synonym: "increased level of antisense transcripts" EXACT [PomBase:al] is_a: FYPO:0000825 ! increased RNA level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards SO:0000644 ! antisense_RNA relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards SO:0000644 ! antisense_RNA created_by: midori creation_date: 2014-07-17T11:14:47Z [Term] id: FYPO:0003558 name: increased repeat element RNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of any RNA transcribed from repeat elements, such as LTRs, retrotransposons, or wtf elements, measured in a cell is higher than normal." [PMID:24957674, PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. subset: qc_do_not_manually_annotate synonym: "increased repeat element RNA accumulation" RELATED [PomBase:mah] synonym: "increased repeat element RNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased repeat element RNA level during vegetative growth" EXACT [PomBase:mah] synonym: "increased repeat element transcript level" EXACT [PomBase:vw] is_a: FYPO:0000825 ! increased RNA level during vegetative growth created_by: midori creation_date: 2014-07-17T11:26:36Z [Term] id: FYPO:0003559 name: sensitive to doxorubicin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to doxorubicin. Cells stop growing (and may die) at a concentration of doxorubicin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to doxorubicin" EXACT [PomBase:mah] synonym: "sensitive to doxorubicin" EXACT [CHEBI:28748] synonym: "sensitive to doxorubicin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to doxorubicin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:28748 ! doxorubicin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:28748 ! doxorubicin created_by: midori creation_date: 2014-07-17T14:35:50Z [Term] id: FYPO:0003560 name: abnormal spindle pole body organization def: "A cell phenotype in which spindle pole body organization is abnormal. Spindle pole body organization is a process that results in the assembly, arrangement of constituent parts, or disassembly of the spindle pole body (SPB)." [GO:0051300, PomBase:mah] synonym: "abnormal SPB organization" EXACT [PomBase:mah] synonym: "abnormal spindle pole body organisation" EXACT [PomBase:mah] is_a: FYPO:0000335 ! abnormal cellular component organization is_a: FYPO:0002734 ! abnormal cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0051300 ! spindle pole body organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0051300 ! spindle pole body organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-07-17T14:39:15Z [Term] id: FYPO:0003561 name: abnormal prospore-specific spindle pole body remodeling def: "A cell phenotype in which prospore-specific spindle pole body remodeling is abnormal. Prospore-specific spindle pole body remodeling takes place during the second meiotic division during ascospore formation and results in the structural reorganization of the SPB, including the recruitment of sporulation-specific proteins to the outer plaque to form the meiotic outer plaque (MOP)." [GO:001322, PomBase:mah] synonym: "abnormal ascospore-type prospore-specific spindle pole body remodeling" EXACT [GO:0031322] synonym: "abnormal forespore-specific spindle pole body remodeling" EXACT [PomBase:mah] synonym: "abnormal prospore-specific SPB remodeling" EXACT [PomBase:mah] is_a: FYPO:0002739 ! abnormal meiotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0031322 ! ascospore-type prospore-specific spindle pole body remodeling intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0031322 ! ascospore-type prospore-specific spindle pole body remodeling relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-07-17T14:41:46Z [Term] id: FYPO:0003562 name: normal horsetail nucleus morphology def: "A physical cellular phenotype in which the size, shape, or structure of the horsetail nucleus is normal (i.e. indistinguishable from wild type). The horsetail nucleus forms during the rapid oscillatory movement at meiotic prophase I." [PomBase:mah] comment: Note that an abnormal nucleus organization process may, but does not necessarily, result in abnormal nuclear morphology. Consider also annotating to 'normal horsetail movement' (FYPO:0003835). synonym: "normal horsetail nuclear morphology" EXACT [PomBase:mah] is_a: FYPO:0001673 ! normal nuclear morphology intersection_of: PATO:0000051 ! morphology intersection_of: inheres_in GO:0071686 ! horsetail nucleus intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0071686 ! horsetail nucleus relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-07-17T15:14:25Z [Term] id: FYPO:0003563 name: normal meiosis I def: "A cellular process phenotype in which the first meiotic nuclear division is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal first meiotic nuclear division" EXACT [PomBase:mah] is_a: FYPO:0000478 ! normal meiosis intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0007127 ! meiosis I intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0007127 ! meiosis I relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-07-17T15:15:34Z [Term] id: FYPO:0003564 name: abnormal meiotic DNA double-strand break formation def: "A cellular process phenotype in which generation of double-strand breaks at defined hotspots throughout the genome during meiosis I is abnormal." [GO:0042138, PomBase:mah] is_a: FYPO:0000008 ! abnormal meiotic recombination intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0042138 ! meiotic DNA double-strand break formation intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0042138 ! meiotic DNA double-strand break formation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-07-17T15:16:48Z [Term] id: FYPO:0003565 name: increased protein phosphorylation during meiosis I def: "A cellular process phenotype in which the phosphorylation of one or more specific proteins occurs to a greater extent than normal during the first meiotic nuclear division." [PomBase:mah] synonym: "increased protein phosphorylation during first meiotic nuclear division" EXACT [PomBase:vw] is_a: FYPO:0002680 ! increased protein phosphorylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0007127 ! meiosis I intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0007127 ! meiosis I relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2014-07-17T15:17:53Z [Term] id: FYPO:0003566 name: delayed spindle pole body separation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which spindle pole body separation begins later than normal." [PomBase:mah] synonym: "delayed SPB separation" EXACT [PomBase:mah] synonym: "delayed spindle pole body separation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "spindle pole body separation delayed during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001733 ! abnormal spindle pole body separation is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000073 ! spindle pole body separation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000073 ! spindle pole body separation created_by: midori creation_date: 2014-07-17T15:49:09Z [Term] id: FYPO:0003567 name: abnormal establishment of mitotic spindle pole body localization to nuclear envelope def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the transport and insertion of a spindle pole body into the nuclear envelope is abnormal." [PMID:24963130, PomBase:mah] synonym: "abnormal establishment of mitotic SPB localization to nuclear envelope" EXACT [PomBase:mah] synonym: "abnormal establishment of spindle pole body localisation to nuclear envelope" EXACT [PomBase:mah] synonym: "abnormal establishment of spindle pole body localization to nuclear envelope during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal mitotic SPB insertion into nuclear envelope" EXACT [PomBase:vw] synonym: "abnormal mitotic spindle pole body insertion into nuclear envelope" EXACT [PomBase:vw] is_a: FYPO:0000534 ! abnormal spindle pole body localization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0071790 ! establishment of spindle pole body localization to nuclear envelope intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0071790 ! establishment of spindle pole body localization to nuclear envelope relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-07-17T16:57:31Z [Term] id: FYPO:0003568 name: abnormal establishment of mitotic spindle pole body localization to nuclear envelope, with spindle pole body in nucleoplasm def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the transport and insertion of a spindle pole body (SPB) into the nuclear envelope is abnormal, and the SPB enters the nucleus. An open fenestra remains present in the nuclear envelope." [PMID:24963130, PomBase:mah] synonym: "abnormal establishment of mitotic SPB localization to nuclear envelope, with spindle pole body in nucleoplasm" EXACT [PomBase:mah] synonym: "abnormal establishment of spindle pole body localisation to nuclear envelope, with spindle pole body in nucleoplasm" EXACT [PomBase:mah] synonym: "abnormal establishment of spindle pole body localization to nuclear envelope, with spindle pole body in nucleoplasm, during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal mitotic SPB insertion into nuclear envelope, with spindle pole body in nucleoplasm" EXACT [PomBase:vw] synonym: "abnormal mitotic spindle pole body insertion into nuclear envelope, with spindle pole body in nucleoplasm" EXACT [PomBase:vw] is_a: FYPO:0003567 ! abnormal establishment of mitotic spindle pole body localization to nuclear envelope created_by: midori creation_date: 2014-07-17T17:01:29Z [Term] id: FYPO:0003569 name: abnormal establishment of mitotic spindle pole body localization to nuclear envelope, with spindle pole body in cytoplasm def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the transport and insertion of a spindle pole body (SPB) into the nuclear envelope is abnormal, and the SPB enters the cytoplasm. An open fenestra remains present in the nuclear envelope." [PMID:24963130, PomBase:mah] synonym: "abnormal establishment of mitotic SPB localization to nuclear envelope, with spindle pole body in cytoplasm" EXACT [PomBase:mah] synonym: "abnormal establishment of spindle pole body localisation to nuclear envelope, with spindle pole body in cytoplasm" EXACT [PomBase:mah] synonym: "abnormal establishment of spindle pole body localization to nuclear envelope, with spindle pole body in cytoplasm, during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal mitotic SPB insertion into nuclear envelope, with spindle pole body in cytoplasm" EXACT [PomBase:vw] synonym: "abnormal mitotic spindle pole body insertion into nuclear envelope, with spindle pole body in cytoplasm" EXACT [PomBase:vw] is_a: FYPO:0003567 ! abnormal establishment of mitotic spindle pole body localization to nuclear envelope created_by: midori creation_date: 2014-07-17T17:03:47Z [Term] id: FYPO:0003570 name: normal attachment of spindle microtubules to kinetochore def: "A cellular process phenotype in which the attachment of spindle microtubules to the kinetochore during a mitotic or meiotic nuclear division is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000899 ! normal microtubule cytoskeleton organization is_a: FYPO:0001334 ! regulation phenotype during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0008608 ! attachment of spindle microtubules to kinetochore intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0008608 ! attachment of spindle microtubules to kinetochore relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-07-23T16:52:09Z [Term] id: FYPO:0003571 name: decreased histone H3-K9 methylation at mating-type region heterochromatin def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which methylation of lysine at position 9 of histone H3 in heterochromatin at the silenced mating-type region occurs to a lower extent than normal." [PMID:18761674, PomBase:mah] synonym: "decreased histone H3 K9 methylation at mating-type region heterochromatin" EXACT [GO:0051567, PomBase:mah] synonym: "decreased histone H3-K9 methylation at mating-type region heterochromatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H3-K9 methylation at mating-type region heterochromatin during vegetative growth" EXACT [PomBase:mah] synonym: "decreased histone H3-K9 methylation at silent mating locus" EXACT [PomBase:al] synonym: "decreased histone H3K9me at mating-type region heterochromatin" EXACT [GO:0051567, PomBase:mah] synonym: "decreased histone lysine H3 K9 methylation at mating-type region heterochromatin" EXACT [GO:0051567, PomBase:mah] synonym: "reduced histone H3-K9 methylation at mating-type region heterochromatin" EXACT [PomBase:mah] is_a: FYPO:0000872 ! decreased histone H3-K9 methylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051567 ! histone H3-K9 methylation intersection_of: occurs_in GO:0031934 ! mating-type region heterochromatin relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051567 ! histone H3-K9 methylation relationship: occurs_in GO:0031934 ! mating-type region heterochromatin created_by: midori creation_date: 2014-07-22T11:45:07Z [Term] id: FYPO:0003572 name: decreased histone H3-K9 methylation at subtelomeric heterochromatin def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which methylation of lysine at position 9 of histone H3 in heterochromatin at subtelomeric regions occurs to a lower extent than normal." [PMID:18761674, PomBase:mah] synonym: "decreased histone H3 K9 methylation at subtelomeric heterochromatin" EXACT [GO:0051567, PomBase:mah] synonym: "decreased histone H3-K9 methylation at subtelomeres" EXACT [PomBase:al] synonym: "decreased histone H3-K9 methylation at subtelomeric heterochromatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H3-K9 methylation at subtelomeric heterochromatin during vegetative growth" EXACT [PomBase:mah] synonym: "decreased histone H3K9me at subtelomeric heterochromatin" EXACT [GO:0051567, PomBase:mah] synonym: "decreased histone lysine H3 K9 methylation at subtelomeric heterochromatin" EXACT [GO:0051567, PomBase:mah] synonym: "reduced histone H3-K9 methylation at subtelomeric heterochromatin" EXACT [PomBase:mah] is_a: FYPO:0000872 ! decreased histone H3-K9 methylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051567 ! histone H3-K9 methylation intersection_of: occurs_in GO:1990421 ! subtelomeric heterochromatin relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051567 ! histone H3-K9 methylation relationship: occurs_in GO:1990421 ! subtelomeric heterochromatin created_by: midori creation_date: 2014-07-22T11:55:29Z [Term] id: FYPO:0003573 name: decreased protein localization to mating-type region heterochromatin def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to heterochromatin at the silenced mating-type region is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to heterochromatin at mating-type region" EXACT [PomBase:mah] synonym: "decreased protein localization to heterochromatin at mating-type region" EXACT [PomBase:mah] synonym: "decreased protein localization to heterochromatin at mating-type region during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein localization to mating-type region heterochromatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to mating-type region heterochromatin during vegetative growth" EXACT [PomBase:al] synonym: "decreased protein localization to silent mating type heterochromatin" EXACT [PomBase:al] synonym: "reduced protein localization to heterochromatin at mating-type region" EXACT [PomBase:mah] is_a: FYPO:0002385 ! decreased protein localization to heterochromatin during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903212 ! protein localization to mating-type region heterochromatin relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903212 ! protein localization to mating-type region heterochromatin created_by: midori creation_date: 2014-07-22T12:01:04Z [Term] id: FYPO:0003574 name: normal histone H3-K14 acetylation at centromere outer repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which acetylation of lysine at position 14 of histone H3 in centromere outer repeat regions is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal histone H3-K14 acetylation at centromere otr" EXACT [PomBase:mah] synonym: "normal histone H3-K14 acetylation at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal histone H3-K14 acetylation at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] synonym: "normal histone H3-K14 acetylation at centromeric outer repeat region" EXACT [PomBase:mah] synonym: "normal histone H3-K14 acetylation at pericentric region" RELATED [PomBase:mah] synonym: "normal histone H3-K14 acetylation at pericentromeric region" RELATED [PomBase:mah] synonym: "normal histone H3K14 acetylation at centromere outer repeat" EXACT [GO:0044154, PomBase:vw] is_a: FYPO:0003224 ! normal histone H3-K14 acetylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0044154 ! histone H3-K14 acetylation intersection_of: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0044154 ! histone H3-K14 acetylation relationship: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-07-22T12:05:26Z [Term] id: FYPO:0003575 name: normal histone H3-K9 acetylation at centromere outer repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which acetylation of lysine at position 9 of histone H3 in centromere outer repeat regions is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal histone H3-K9 acetylation at centromere otr" EXACT [PomBase:mah] synonym: "normal histone H3-K9 acetylation at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal histone H3-K9 acetylation at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] synonym: "normal histone H3-K9 acetylation at centromeric outer repeat region" EXACT [PomBase:mah] synonym: "normal histone H3-K9 acetylation at pericentric region" RELATED [PomBase:mah] synonym: "normal histone H3-K9 acetylation at pericentromeric region" RELATED [PomBase:mah] synonym: "normal histone H3K9 acetylation at centromere outer repeat" EXACT [GO:0043970, PomBase:vw] is_a: FYPO:0003223 ! normal histone H3-K9 acetylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0043970 ! histone H3-K9 acetylation intersection_of: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0043970 ! histone H3-K9 acetylation relationship: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-07-22T12:07:12Z [Term] id: FYPO:0003576 name: normal protein localization to subtelomeric heterochromatin def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to heterochromatin in subtelomeric regions is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to subtelomeric heterochromatin" EXACT [PomBase:mah] synonym: "normal protein localization to subtelomeric heterochromatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to subtelomeric heterochromatin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001509 ! normal protein localization to chromatin intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903213 ! protein localization to subtelomeric heterochromatin intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903213 ! protein localization to subtelomeric heterochromatin relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-07-22T12:15:47Z [Term] id: FYPO:0003577 name: abolished plasma membrane to vacuole transport after nitrogen starvation def: "A cellular process phenotype in which the transport of a substance from the plasma membrane to the vacuole does not occur when the cell is subject to, or recovering from, nitrogen starvation. Transport normally occurs in two stages, plasma membrane to endosome followed by endosome to vacuole transport." [PMID:22194353, PomBase:mah] comment: This term can be used to annotate phenotypes in which a protein that normally appears at the plasma membrane transiently during nitrogen starvation is not subsequently transported to the vacuole. is_a: FYPO:0003578 ! abnormal vacuolar transport created_by: midori creation_date: 2014-07-22T12:35:29Z [Term] id: FYPO:0003578 name: abnormal vacuolar transport def: "A cellular process phenotype in which vacuolar transport is abnormal." [PomBase:mah] synonym: "vacuolar transport: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001720 ! abnormal transport intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0007034 ! vacuolar transport intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0007034 ! vacuolar transport relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-07-22T12:52:21Z [Term] id: FYPO:0003579 name: normal RNA level during meiosis def: "A cell phenotype in which the amount of RNA measured in a cell during ore or both meiotic nuclear divisions is normal (i.e. indistinguishable from wild type). Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [PomBase:mah] comment: We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "normal cellular RNA level during meiosis" EXACT [PomBase:mah] synonym: "normal mRNA level during meiosis" NARROW [PomBase:mah] synonym: "normal RNA accumulation during meiosis" RELATED [PomBase:mah] synonym: "normal RNA level during meiotic nuclear division" EXACT [GO:0007126] is_a: FYPO:0000840 ! normal RNA level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0007126 ! meiotic nuclear division intersection_of: inheres_in CL:0000000 ! cell intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0007126 ! meiotic nuclear division relationship: inheres_in CL:0000000 ! cell relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-07-22T13:51:14Z [Term] id: FYPO:0003580 name: increased number of Sad1 foci during response to DNA damage def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the number of sites at which the protein Sad1 accumulates is greater than normal during a cellular response to DNA damage." [PMID:24943839, PomBase:mah] comment: Sad1 is normally located at the spindle pole body, but during a response to DNA damage, Sad1 foci associated with double-strand breaks appear. synonym: "increased number of Sad1 foci during DNA damage response" EXACT [PomBase:vw] synonym: "increased number of Sad1 foci during response to DNA damage during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased number of Sad1 foci during response to DNA damage during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001321 ! cellular physical quality phenotype during vegetative growth created_by: midori creation_date: 2014-07-22T14:27:55Z [Term] id: FYPO:0003581 name: increased number of Kms1 foci def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the number of sites at which the protein Kms1 accumulates is greater than normal." [PMID:24943839, PomBase:mah] synonym: "increased number of Kms1 foci during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased number of Kms1 foci during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001321 ! cellular physical quality phenotype during vegetative growth created_by: midori creation_date: 2014-07-22T14:31:04Z [Term] id: FYPO:0003582 name: increased number of Kms1 foci during response to DNA damage def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the number of sites at which the protein Kms1 accumulates is greater than normal during a cellular response to DNA damage." [PMID:24943839, PomBase:mah] synonym: "increased number of Kms1 foci during DNA damage response" EXACT [PomBase:vw] synonym: "increased number of Kms1 foci during response to DNA damage during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased number of Kms1 foci during response to DNA damage during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003581 ! increased number of Kms1 foci created_by: midori creation_date: 2014-07-22T14:32:13Z [Term] id: FYPO:0003583 name: increased rate of Sad1 focus formation during response to DNA damage def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the rate, or speed, of formation of foci containing the protein Sad1 is increased during a cellular response to DNA damage." [PMID:24943839, PomBase:mah] synonym: "increased rate of accumulation of Sad1 foci during DNA damage response" EXACT [PomBase:vw] synonym: "increased rate of Sad1 focus formation during response to DNA damage during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased rate of Sad1 focus formation during response to DNA damage during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001354 ! abnormal cellular component assembly during vegetative growth created_by: midori creation_date: 2014-07-22T14:36:20Z [Term] id: FYPO:0003584 name: increased double-strand break repair via nonhomologous end joining def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of double-strand break repair via nonhomologous end joining (NHEJ) is increased. NHEJ is the repair of double-strand breaks in DNA in which the two broken ends are rejoined with little or no sequence complementarity." [GO:0006303, PomBase:mah] synonym: "increased double-strand break repair via nonhomologous end joining during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased double-strand break repair via nonhomologous end joining during vegetative growth" EXACT [PomBase:mah] synonym: "increased NHEJ" EXACT [GO:0006303] synonym: "increased nonhomologous end joining" EXACT [PomBase:mah] is_a: FYPO:0000777 ! abnormal double-strand break repair is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006303 ! double-strand break repair via nonhomologous end joining relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006303 ! double-strand break repair via nonhomologous end joining created_by: midori creation_date: 2014-07-22T14:39:47Z [Term] id: FYPO:0003585 name: decreased anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of ubiquitin-dependent protein degradation with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome, is decreased." [GO:0031145, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process during vegetative growth" EXACT [PomBase:mah] synonym: "decreased anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein degradation" EXACT [GO:0031145, PomBase:mah] synonym: "reduced anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process" EXACT [PomBase:mah] is_a: FYPO:0004545 ! decreased proteasomal ubiquitin-dependent protein degradation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0031145 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0031145 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process created_by: midori creation_date: 2014-07-22T14:51:20Z [Term] id: FYPO:0003586 name: abnormal replication fork processing def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which replication fork processing is abnormal. Replication fork processing is process in which a DNA replication fork that has stalled (due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes) is repaired and replication is restarted." [GO:0031297, PomBase:mah] synonym: "abnormal collapsed replication fork processing" EXACT [GO:0031297] synonym: "abnormal recovery from replication fork arrest" EXACT [GO:0031297] synonym: "abnormal recovery from replication fork stalling" EXACT [GO:0031297] synonym: "abnormal replication fork processing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal replication fork processing during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal replication fork restart" RELATED [GO:0031297] synonym: "abnormal replication restart" RELATED [GO:0031297] is_a: FYPO:0000157 ! abnormal response to DNA damage stimulus is_a: FYPO:0001346 ! DNA metabolism phenotype during vegetative growth is_a: FYPO:0001363 ! abnormal metabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0031297 ! replication fork processing intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0031297 ! replication fork processing relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-07-22T14:54:31Z [Term] id: FYPO:0003587 name: loss of gross chromosomal rearrangement during replication fork processing def: "A cell phenotype in which the increase in gross chromosomal rearrangements that normally results from processing arrested replication forks is diminished or abolished." [PMID:23093942, PomBase:mah] is_a: FYPO:0003586 ! abnormal replication fork processing created_by: midori creation_date: 2014-07-22T14:59:24Z [Term] id: FYPO:0003588 name: increased gross chromosomal rearrangement during replication fork processing def: "A cell phenotype in which the increase in gross chromosomal rearrangements that normally results from processing arrested replication forks is enhanced, i.e. the incidence of rearrangement increases more than in wild type when an arrested fork is processed." [PMID:23093942, PomBase:mah] is_a: FYPO:0003586 ! abnormal replication fork processing created_by: midori creation_date: 2014-07-22T15:00:00Z [Term] id: FYPO:0003589 name: decreased replication slippage during replication fork processing def: "A cell phenotype in which the increase in small deletions or duplications (\"replication slippage\") that normally results from processing arrested replication forks is diminished or abolished." [PMID:23093942, PomBase:mah] synonym: "reduced replication slippage during replication fork processing" EXACT [PomBase:mah] is_a: FYPO:0003586 ! abnormal replication fork processing created_by: midori creation_date: 2014-07-22T15:00:17Z [Term] id: FYPO:0003590 name: small vacuoles during sporulation def: "A cell phenotype in which vacuoles are smaller than normal during sporulation." [PomBase:mah] is_a: FYPO:0002787 ! small vacuoles intersection_of: PATO:0000596 ! decreased volume intersection_of: exists_during GO:0030437 ! ascospore formation intersection_of: inheres_in GO:0000324 ! fungal-type vacuole relationship: exists_during GO:0030437 ! ascospore formation relationship: inheres_in GO:0000324 ! fungal-type vacuole created_by: midori creation_date: 2014-07-22T15:12:40Z [Term] id: FYPO:0003591 name: abnormal protein complex binding def: "A molecular function phenotype in which the binding of one protein to a protein complex is abnormal. The protein whose binding to the protein complex is affected may be encoded by the mutated gene, or may be encoded by a different gene." [PomBase:mah] comment: This term can be used for any interaction with a protein complex that is affected by a mutation, whether or not the mutated gene product is one of the interacting proteins. We recommend noting which proteins were used in the assay when annotating to this term. is_a: FYPO:0000704 ! abnormal protein binding intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0032403 ! protein complex binding intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0032403 ! protein complex binding relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-07-23T16:54:48Z [Term] id: FYPO:0003592 name: increased anaphase-promoting complex binding def: "A molecular function phenotype in which the binding of one protein to the anaphase-promoting complex (APC) occurs to a greater extent than normal. The protein whose binding to the APC may be encoded by the mutated gene, or may be encoded by a different gene." [PomBase:mah] comment: This term can be used for any interaction with the APC that is affected by a mutation, whether or not the mutated gene product is one of the interacting proteins. We recommend noting which proteins were used in the assay when annotating to this term. is_a: FYPO:0003591 ! abnormal protein complex binding intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0010997 ! anaphase-promoting complex binding intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0010997 ! anaphase-promoting complex binding relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-07-23T16:56:15Z [Term] id: FYPO:0003593 name: abolished anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of ubiquitin-dependent protein degradation with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome, is abolished." [GO:0031145, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process during vegetative growth" EXACT [PomBase:mah] synonym: "abolished anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein degradation" EXACT [GO:0031145, PomBase:mah] synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process abolished" EXACT [PomBase:mah] is_a: FYPO:0000846 ! decreased protein degradation during vegetative growth is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0031145 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0031145 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process created_by: midori creation_date: 2014-07-23T16:58:29Z [Term] id: FYPO:0003594 name: normal anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of ubiquitin-dependent protein degradation with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome, is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process during vegetative growth" EXACT [PomBase:mah] synonym: "normal anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein degradation" EXACT [GO:0031145, PomBase:mah] is_a: FYPO:0000859 ! normal metabolic process during vegetative growth is_a: FYPO:0002800 ! normal protein degradation during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0031145 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0031145 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-07-23T17:00:08Z [Term] id: FYPO:0003595 name: S-shaped cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a single cell grows in a shape that consists of two curves in opposite directions." [PomBase:mah] synonym: "kinked cell" EXACT [PomBase:mah] synonym: "kinky cell" EXACT [PomBase:mah] synonym: "S-shaped vegetative cell" EXACT [PomBase:mah] synonym: "sigmoid cell" EXACT [PomBase:mah] synonym: "Z-shaped cell" EXACT [PomBase:mah] is_a: FYPO:0002196 ! abnormal vegetative cell shape is_a: PATO:0001878 ! sigmoid intersection_of: PATO:0001878 ! sigmoid intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) created_by: midori creation_date: 2014-07-29T14:55:16Z [Term] id: FYPO:0003596 name: abnormal snRNA 3'-end processing def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which formation of the mature 3' end of an snRNA molecule is abnormal." [GO:0034472, PomBase:mah] synonym: "abnormal snRNA 3'-end processing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal snRNA 3'-end processing during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001553 ! abnormal RNA processing intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0034472 ! snRNA 3'-end processing intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0034472 ! snRNA 3'-end processing relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-07-29T15:15:29Z [Term] id: FYPO:0003597 name: abolished snRNA 3'-end processing def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which formation of the mature 3' end of an snRNA molecule is abolished." [GO:0034472, PomBase:mah] synonym: "abolished snRNA 3'-end processing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished snRNA 3'-end processing during vegetative growth" EXACT [PomBase:mah] synonym: "snRNA 3'-end processing abolished" EXACT [PomBase:mah] is_a: FYPO:0003596 ! abnormal snRNA 3'-end processing is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0034472 ! snRNA 3'-end processing relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0034472 ! snRNA 3'-end processing created_by: midori creation_date: 2014-07-29T15:17:08Z [Term] id: FYPO:0003598 name: decreased snRNA 3'-end processing def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which formation of the mature 3' end of an snRNA molecule is decreased." [GO:0034472, PomBase:mah] synonym: "decreased snRNA 3'-end processing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased snRNA 3'-end processing during vegetative growth" EXACT [PomBase:mah] synonym: "reduced snRNA 3'-end processing" EXACT [PomBase:mah] is_a: FYPO:0003596 ! abnormal snRNA 3'-end processing is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034472 ! snRNA 3'-end processing relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034472 ! snRNA 3'-end processing created_by: midori creation_date: 2014-07-29T15:17:54Z [Term] id: FYPO:0003599 name: normal snRNA 3'-end processing def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which formation of the mature 3' end of an snRNA molecule is normal (i.e. indistinguishable from wild type)." [GO:0034472, PomBase:mah] synonym: "normal snRNA 3'-end processing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal snRNA 3'-end processing during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001980 ! normal RNA processing intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034472 ! snRNA 3'-end processing intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034472 ! snRNA 3'-end processing relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-07-29T15:18:15Z [Term] id: FYPO:0003600 name: increased rRNA precursor level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of any rRNA precursor measured in a cell is higher than normal." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "increased rRNA precursor accumulation" RELATED [PomBase:mah] synonym: "increased rRNA precursor level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased rRNA precursor level during vegetative growth" EXACT [PomBase:mah] synonym: "increased rRNA precursor transcript level" EXACT [PomBase:vw] is_a: FYPO:0000825 ! increased RNA level during vegetative growth created_by: midori creation_date: 2014-07-29T15:21:16Z [Term] id: FYPO:0003601 name: decreased rRNA precursor level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of any rRNA precursor measured in a cell is lower than normal." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "decreased rRNA precursor accumulation" RELATED [PomBase:mah] synonym: "decreased rRNA precursor level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased rRNA precursor level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased rRNA precursor transcript level" EXACT [PomBase:vw] synonym: "reduced rRNA precursor level" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth created_by: midori creation_date: 2014-07-29T15:22:13Z [Term] id: FYPO:0003602 name: abolished mRNA splicing, via spliceosome def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of mRNA splicing via the spliceosome is abolished." [PMID:24298023, PomBase:mah] synonym: "abolished mRNA splicing, via spliceosome during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished mRNA splicing, via spliceosome during vegetative growth" EXACT [PomBase:mah] synonym: "abolished nuclear mRNA splicing, via spliceosome" EXACT [PomBase:mah] synonym: "abolished splicing" BROAD [PomBase:al] synonym: "mRNA splicing via spliceosome abolished" EXACT [PomBase:mah] is_a: FYPO:0000189 ! abnormal mRNA splicing, via spliceosome is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0000398 ! mRNA splicing, via spliceosome relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0000398 ! mRNA splicing, via spliceosome created_by: midori creation_date: 2014-07-29T15:26:02Z [Term] id: FYPO:0003603 name: abnormal meiosis I def: "A cellular process phenotype in which the first meiotic division is abnormal." [PomBase:mah] synonym: "abnormal first meiotic nuclear division" EXACT [GO:0007127] is_a: FYPO:0000051 ! abnormal meiosis intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0007127 ! meiosis I intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0007127 ! meiosis I relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-07-29T16:05:41Z [Term] id: FYPO:0003604 name: sister chromatid separation during meiosis I def: "A cellular process phenotype in which sister chromatids become physically detached from one another during the first meiotic division, instead of remaining attached and segregating together. Sister chromatids normally do not separate until the second meiotic division." [PMID:10440376, PomBase:mah] synonym: "abnormal sister chromatid separation at meiosis I" EXACT [PomBase:al] synonym: "equational sister chromatid segregation at meiosis I" EXACT [PMID:10440376, PomBase:al] is_a: FYPO:0003603 ! abnormal meiosis I relationship: output_of FYPO:0002093 ! decreased meiotic sister chromatid cohesion created_by: midori creation_date: 2014-07-29T16:08:54Z [Term] id: FYPO:0003606 name: decreased duration of meiotic prophase I def: "A cellular process phenotype in which the duration of prophase of the first meiotic nuclear division is shorter than normal." [PomBase:mah] synonym: "reduced duration of meiotic prophase I" EXACT [PomBase:mah] synonym: "short meiotic prophase I" EXACT [PomBase:al] is_a: FYPO:0000051 ! abnormal meiosis is_a: FYPO:0000410 ! decreased duration of cell cycle phase intersection_of: PATO:0000499 ! decreased duration intersection_of: inheres_in GO:0007128 ! meiotic prophase I relationship: inheres_in GO:0007128 ! meiotic prophase I created_by: midori creation_date: 2014-07-29T16:21:25Z [Term] id: FYPO:0003607 name: abnormal spindle morphology def: "A physical cellular phenotype in which the size, shape, or structure of the mitotic or meiotic spindle is abnormal." [PomBase:mah] synonym: "spindle morphology: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0000120 ! abnormal spindle is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: inheres_in GO:0005819 ! spindle intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0005819 ! spindle relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-07-30T15:30:35Z [Term] id: FYPO:0003608 name: abnormal dehydrodolichyl diphosphate synthase activity def: "A molecular function phenotype in which the observed rate of dehydrodolichyl diphosphate synthase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0045547 ! dehydrodolichyl diphosphate synthase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0045547 ! dehydrodolichyl diphosphate synthase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-07-31T17:22:13Z [Term] id: FYPO:0003609 name: decreased dehydrodolichyl diphosphate synthase activity def: "A molecular function phenotype in which the observed rate of dehydrodolichyl diphosphate synthase activity is decreased." [PomBase:mah] synonym: "reduced dehydrodolichyl diphosphate synthase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0003608 ! abnormal dehydrodolichyl diphosphate synthase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0045547 ! dehydrodolichyl diphosphate synthase activity relationship: inheres_in GO:0045547 ! dehydrodolichyl diphosphate synthase activity created_by: midori creation_date: 2014-07-31T17:22:21Z [Term] id: FYPO:0003610 name: branched, elongated cell with branch forming adjacent to septum def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is longer than normal and a branch forms adjacent to an existing septum." [PomBase:mah, PomBase:vw] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "branched, elongated cell with branch forming adjacent to septum during mitotic cell cycle" RELATED [PomBase:mah] synonym: "branched, elongated cell with branch forming adjacent to septum during vegetative growth" EXACT [PomBase:mah] synonym: "branched, elongated vegetative cell with branch forming adjacent to septum" EXACT [PomBase:mah] is_a: FYPO:0002459 ! viable branched, elongated vegetative cell created_by: midori creation_date: 2014-08-06T10:44:06Z [Term] id: FYPO:0003611 name: increased protein level during meiosis def: "A cell phenotype in which the amount of protein measured in a cell during one or both meiotic nuclear divisions is higher than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein accumulation during meiosis" RELATED [PomBase:mah] synonym: "increased protein level during meiotic nuclear division" EXACT [PomBase:vw] is_a: FYPO:0000836 ! increased protein level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0007126 ! meiotic nuclear division intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0007126 ! meiotic nuclear division relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2014-08-06T11:36:40Z [Term] id: FYPO:0003612 name: viable spore population def: "A cell population phenotype in which cells in a population of spores are viable." [PomBase:mah] synonym: "viable population of spores" EXACT [PomBase:vw] is_a: FYPO:0002058 ! viable cell population created_by: midori creation_date: 2014-08-06T11:38:17Z [Term] id: FYPO:0003613 name: normal meiotic sister chromatid cohesion during prophase I def: "A cellular process phenotype in which cohesion between sister chromatids is normal (i.e. indistinguishable from wild type) during prophase of the first meiotic nuclear division." [PomBase:mah] synonym: "normal sister chromatid cohesion during meiotic prophase I" EXACT [PomBase:mah] is_a: FYPO:0002094 ! normal meiotic sister chromatid cohesion intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0007136 ! meiotic prophase II intersection_of: inheres_in GO:0051177 ! meiotic sister chromatid cohesion intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0007136 ! meiotic prophase II relationship: inheres_in GO:0051177 ! meiotic sister chromatid cohesion relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-08-06T11:39:43Z [Term] id: FYPO:0003614 name: meiotic spindle absent from cell during meiosis II def: "A cell phenotype in which the cell does not contain a detectable meiotic spindle during the second meiotic nuclear division." [PomBase:mah] synonym: "absent meiotic spindle during meiosis II" EXACT [PomBase:mah] synonym: "meiosis II spindle absent" EXACT [PomBase:al] is_a: FYPO:0000734 ! abnormal meiotic spindle is_a: PATO:0002000 ! lacks all parts of type intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0007135 ! meiosis II intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards GO:0072687 ! meiotic spindle relationship: during GO:0007135 ! meiosis II relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards GO:0072687 ! meiotic spindle created_by: midori creation_date: 2014-08-06T11:41:57Z [Term] id: FYPO:0003615 name: decreased meiotic DNA double-strand break formation def: "A cellular process phenotype in which generation of double-strand breaks at defined hotspots throughout the genome during meiosis I is decreased." [GO:0042138, PomBase:mah] synonym: "reduced meiotic DNA double-strand break formation" EXACT [PomBase:mah] is_a: FYPO:0000008 ! abnormal meiotic recombination is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0042138 ! meiotic DNA double-strand break formation relationship: inheres_in GO:0042138 ! meiotic DNA double-strand break formation created_by: midori creation_date: 2014-08-06T11:45:30Z [Term] id: FYPO:0003616 name: sensitive to fluphenazine def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to fluphenazine. Cells stop growing (and may die) at a concentration of fluphenazine that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to fluphenazine" EXACT [PomBase:mah] synonym: "sensitive to fluphenazine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to fluphenazine during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:5123 ! fluphenazine relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:5123 ! fluphenazine created_by: midori creation_date: 2014-08-06T11:57:20Z [Term] id: FYPO:0003617 name: sensitive to cytochalasin D def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to cytochalasin D. Cells stop growing (and may die) at a concentration of cytochalasin D that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to cytochalasin D" EXACT [PomBase:mah] synonym: "sensitive to cytochalasin D during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to cytochalasin D during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:529996 ! cytochalasin D relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:529996 ! cytochalasin D created_by: midori creation_date: 2014-08-06T11:58:04Z [Term] id: FYPO:0003618 name: normal growth on aculeacin A def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing aculeacin A." [PomBase:mah] synonym: "normal cell population growth in presence of aculeacin A" EXACT [PomBase:mah] synonym: "normal cell population growth on aculeacin A" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to aculeacin A" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on aculeacin A" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:2450 ! aculeacin A relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:2450 ! aculeacin A created_by: midori creation_date: 2014-08-06T11:58:44Z [Term] id: FYPO:0003619 name: normal mRNA splicing, via spliceosome def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mRNA splicing via the spliceosome is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal mRNA splicing, via spliceosome during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal mRNA splicing, via spliceosome during vegetative growth" EXACT [PomBase:mah] synonym: "normal nuclear mRNA splicing, via spliceosome" EXACT [PomBase:mah] is_a: FYPO:0003468 ! normal RNA splicing intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000398 ! mRNA splicing, via spliceosome intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000398 ! mRNA splicing, via spliceosome relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-08-06T12:06:30Z [Term] id: FYPO:0003620 name: normal pre-mRNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of any unspliced or incompletely spliced mRNA precursor measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "normal pre-mRNA accumulation" RELATED [PomBase:mah] synonym: "normal pre-mRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal pre-mRNA level during vegetative growth" EXACT [PomBase:mah] synonym: "normal pre-mRNA transcript level" EXACT [PomBase:vw] is_a: FYPO:0001317 ! normal RNA level during vegetative growth created_by: midori creation_date: 2014-08-06T12:22:26Z [Term] id: FYPO:0003621 name: abolished U6 2'-O-snRNA methylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which posttranscriptional addition of a methyl group to the 2'-oxygen atom of a nucleotide residue in an U6 snRNA molecule is abolished." [GO:1990438, PomBase:mah] synonym: "abolished U6 2'-O-snRNA methylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "U6 2'-O-snRNA methylation abolished" EXACT [GO:0036261, PomBase:mah] synonym: "U6 2'-O-snRNA methylation abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000371 ! abolished RNA modification intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1990438 ! U6 2'-O-snRNA methylation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1990438 ! U6 2'-O-snRNA methylation created_by: midori creation_date: 2014-08-06T12:24:59Z [Term] id: FYPO:0003622 name: abolished U6 2'-O-snRNA methylation at residue A41 def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which posttranscriptional addition of a methyl group to the 2'-oxygen atom of the adenine residue at position 41 in an U6 snRNA molecule is abolished." [GO:1990438, PomBase:mah] synonym: "abolished U6 2'-O-snRNA methylation at residue A41 during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished U6 A41 2'-O-snRNA methylation" EXACT [PomBase:mah] synonym: "U6 2'-O-snRNA methylation abolished at residue A41 during vegetative growth" EXACT [PomBase:mah] synonym: "U6 2'-O-snRNA methylation at residue A41 abolished" EXACT [GO:0036261, PomBase:mah] is_a: FYPO:0003621 ! abolished U6 2'-O-snRNA methylation created_by: midori creation_date: 2014-08-06T12:26:38Z [Term] id: FYPO:0003623 name: normal protein threonine phosphorylation during cellular response to heat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of threonine residues of one or more specific proteins is normal (i.e. indistinguishable from wild type) during a cellular response to heat." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein threonine phosphorylation during cellular response to heat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein threonine phosphorylation during cellular response to heat during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0004154 ! normal protein phosphorylation during cellular response to heat is_a: FYPO:0004423 ! normal protein threonine phosphorylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0034605 ! cellular response to heat intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0018107 ! peptidyl-threonine phosphorylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0034605 ! cellular response to heat relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0018107 ! peptidyl-threonine phosphorylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-08-06T12:48:30Z [Term] id: FYPO:0003624 name: decreased protein threonine phosphorylation during cellular response to heat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of threonine residues of one or more specific proteins is decreased during a cellular response to heat." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein threonine phosphorylation during cellular response to heat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein threonine phosphorylation during cellular response to heat during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein threonine phosphorylation during cellular response to heat" EXACT [PomBase:mah] is_a: FYPO:0002645 ! decreased protein threonine phosphorylation is_a: FYPO:0004173 ! decreased protein phosphorylation during cellular response to heat intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0034605 ! cellular response to heat intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0018107 ! peptidyl-threonine phosphorylation relationship: happens_during GO:0034605 ! cellular response to heat relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0018107 ! peptidyl-threonine phosphorylation created_by: midori creation_date: 2014-08-06T12:50:27Z [Term] id: FYPO:0003625 name: abnormal microtubule cytoskeleton morphology during mitotic interphase def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of the microtubule cytoskeleton is abnormal during interphase of the mitotic cell cycle." [PomBase:mah] comment: Note that an abnormal microtubule cytoskeleton organization process may, but does not necessarily, result in abnormal microtubule cytoskeleton morphology. synonym: "abnormal microtubule cytoskeleton morphology during interphase of mitotic cell cycle" EXACT [PomBase:mah] synonym: "abnormal microtubule cytoskeleton morphology during mitotic interphase during vegetative growth" RELATED [PomBase:mah] is_a: FYPO:0001418 ! abnormal microtubule cytoskeleton morphology during vegetative growth intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0051329 ! mitotic interphase intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0015630 ! microtubule cytoskeleton intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0051329 ! mitotic interphase relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0015630 ! microtubule cytoskeleton relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-08-06T14:08:42Z [Term] id: FYPO:0003626 name: normal protein localization to shmoo tip def: "A cell phenotype in which the localization of a protein to the tip of a shmoo, or mating projection, is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to shmoo tip" EXACT [PomBase:mah] synonym: "normal protein localization to mating projection tip" EXACT [PomBase:mah] synonym: "normal protein localization to shmoo projection" EXACT [PomBase:al] is_a: FYPO:0000644 ! normal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903260 ! protein localization to mating projection tip intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903260 ! protein localization to mating projection tip relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-08-06T14:22:08Z [Term] id: FYPO:0003627 name: normal protein localization def: "A cell phenotype in which the localization of a protein in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "normal cellular protein localisation" EXACT [PomBase:mah] synonym: "normal cellular protein localization" EXACT [PomBase:mah] synonym: "normal protein localisation" EXACT [PomBase:mah] is_a: FYPO:0000627 ! normal cellular process is_a: FYPO:0002333 ! protein localization phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0034613 ! cellular protein localization intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0034613 ! cellular protein localization relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-08-06T14:23:40Z [Term] id: FYPO:0003628 name: abnormal ribonucleoprotein complex assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which any process of ribonucleoprotein complex assembly is abnormal." [PomBase:mah] synonym: "abnormal protein-RNA complex assembly" EXACT [GO:0022618] synonym: "abnormal ribonucleoprotein complex assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal ribonucleoprotein complex assembly during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal RNA-protein complex assembly" EXACT [GO:0022618] synonym: "abnormal RNP complex assembly" EXACT [GO:0022618] is_a: FYPO:0001354 ! abnormal cellular component assembly during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0022618 ! ribonucleoprotein complex assembly intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0022618 ! ribonucleoprotein complex assembly relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-08-06T14:31:10Z [Term] id: FYPO:0003629 name: abolished U2/U5/U6 snRNP complex assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which spliceosomal tri-snRNP complex assembly is abolished." [PMID:12374752, PomBase:mah] synonym: "abolished U2/U5/U6 snRNP complex assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished U2/U5/U6 snRNP complex assembly during vegetative growth" EXACT [PomBase:mah] synonym: "abolished U2/U5/U6 tri-snRNP complex assembly abolished" EXACT [PomBase:mah] synonym: "U2/U5/U6 snRNP complex assembly abolished" EXACT [PomBase:mah] is_a: FYPO:0003628 ! abnormal ribonucleoprotein complex assembly created_by: midori creation_date: 2014-08-06T14:37:22Z [Term] id: FYPO:0003630 name: abolished U2-type prespliceosome assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which U2-type prespliceosome assembly is abolished. The U2-type prespliceosome is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP, and also contains other proteins." [GO:0071004, GO:1903241, PomBase:mah] synonym: "abolished U2-type prespliceosome assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished U2-type prespliceosome assembly during vegetative growth" EXACT [PomBase:mah] synonym: "U2-type prespliceosome assembly abolished" EXACT [PomBase:mah] is_a: FYPO:0003628 ! abnormal ribonucleoprotein complex assembly is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1903241 ! U2-type prespliceosome assembly relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1903241 ! U2-type prespliceosome assembly created_by: midori creation_date: 2014-08-06T14:42:01Z [Term] id: FYPO:0003631 name: decreased U2-type prespliceosome assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which U2-type prespliceosome assembly is decreased. The U2-type prespliceosome is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP, and also contains other proteins." [GO:0071004, GO:1903241, PomBase:mah] synonym: "decreased U2-type prespliceosome assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased U2-type prespliceosome assembly during vegetative growth" EXACT [PomBase:mah] synonym: "reduced U2-type prespliceosome assembly" EXACT [PomBase:mah] is_a: FYPO:0003628 ! abnormal ribonucleoprotein complex assembly is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903241 ! U2-type prespliceosome assembly relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903241 ! U2-type prespliceosome assembly created_by: midori creation_date: 2014-08-06T14:44:02Z [Term] id: FYPO:0003632 name: abnormal ribonucleoprotein complex binding def: "A molecular function phenotype in which the binding of one gene product (RNA or protein) to a ribonucleoprotein complex is abnormal. The gene product whose binding to the ribonucleoprotein complex is affected may be encoded by the mutated gene, or may be encoded by a different gene." [PomBase:mah] comment: This term can be used for any interaction with a ribonucleoprotein complex that is affected by a mutation, whether or not the mutated gene product is one of the interacting proteins. We recommend noting which proteins were used in the assay when annotating to this term. synonym: "abnormal RNP binding" EXACT [GO:0043021] is_a: FYPO:0000707 ! abnormal molecular function is_a: FYPO:0001092 ! binding phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0043021 ! ribonucleoprotein complex binding intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0043021 ! ribonucleoprotein complex binding relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-08-06T14:51:18Z [Term] id: FYPO:0003633 name: abolished U1 snRNP binding def: "A molecular function phenotype in which U1 snRNP binding by a gene product does not occur. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] comment: This term can be used for any interaction with a U1 snRNP that is affected by a mutation, whether or not the mutated gene product is one of the interacting proteins. We recommend noting which proteins were used in the assay when annotating to this term. synonym: "U1 snRNP binding abolished" EXACT [PomBase:mah] is_a: FYPO:0003632 ! abnormal ribonucleoprotein complex binding is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:1990446 ! U1 snRNP binding relationship: towards GO:1990446 ! U1 snRNP binding created_by: midori creation_date: 2014-08-06T14:53:27Z [Term] id: FYPO:0003634 name: decreased U1 snRNP binding def: "A molecular function phenotype in which U1 snRNP binding by a gene product is decreased. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] comment: This term can be used for any interaction with a U2 snRNP that is affected by a mutation, whether or not the mutated gene product is one of the interacting proteins. We recommend noting which proteins were used in the assay when annotating to this term. synonym: "reduced U1 snRNP binding" EXACT [PomBase:mah] is_a: FYPO:0003632 ! abnormal ribonucleoprotein complex binding is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:1990446 ! U1 snRNP binding relationship: inheres_in GO:1990446 ! U1 snRNP binding created_by: midori creation_date: 2014-08-06T14:55:01Z [Term] id: FYPO:0003635 name: abolished U2 snRNP binding def: "A molecular function phenotype in which U2 snRNP binding by a gene product does not occur. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] comment: This term can be used for any interaction with a U2 snRNP that is affected by a mutation, whether or not the mutated gene product is one of the interacting proteins. We recommend noting which proteins were used in the assay when annotating to this term. synonym: "U2 snRNP binding abolished" EXACT [PomBase:mah] is_a: FYPO:0003632 ! abnormal ribonucleoprotein complex binding is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:1990447 ! U2 snRNP binding relationship: towards GO:1990447 ! U2 snRNP binding created_by: midori creation_date: 2014-08-06T14:55:20Z [Term] id: FYPO:0003636 name: decreased U2 snRNP binding def: "A molecular function phenotype in which U2 snRNP binding by a gene product is decreased. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] comment: This term can be used for any interaction with a U2 snRNP that is affected by a mutation, whether or not the mutated gene product is one of the interacting proteins. We recommend noting which proteins were used in the assay when annotating to this term. synonym: "reduced U2 snRNP binding" EXACT [PomBase:mah] is_a: FYPO:0003632 ! abnormal ribonucleoprotein complex binding is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:1990447 ! U2 snRNP binding relationship: inheres_in GO:1990447 ! U2 snRNP binding created_by: midori creation_date: 2014-08-06T14:55:37Z [Term] id: FYPO:0003637 name: abnormal ADP binding def: "A molecular function phenotype in which occurrence of ADP binding by a gene product (usually a protein) in a mutant is abnormal. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] comment: This term can mean that the mutated gene product itself binds ADP differently from wild type, or that a mutation in one gene affects ADP binding by a second gene product. When using this term, it is therefore recommended to note the specific protein(s) affected. is_a: FYPO:0000707 ! abnormal molecular function is_a: FYPO:0001092 ! binding phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0043531 ! ADP binding intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0043531 ! ADP binding relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-08-06T15:04:17Z [Term] id: FYPO:0003638 name: increased ADP binding def: "A molecular function phenotype in which occurrence of ADP binding by a gene product (usually a protein) in a mutant is increased. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] comment: This term can mean that the mutated gene product itself binds ADP more than wild type, or that a mutation in one gene increases ADP binding by a second gene product. When using this term, it is therefore recommended to note the specific protein(s) affected. is_a: FYPO:0003637 ! abnormal ADP binding is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0043531 ! ADP binding relationship: inheres_in GO:0043531 ! ADP binding created_by: midori creation_date: 2014-08-06T15:04:22Z [Term] id: FYPO:0003639 name: abolished cell wall biogenesis def: "A cellular process phenotype in which cell wall biogenesis is abolished." [PomBase:mah] synonym: "abolished fungal-type cell wall biogenesis" EXACT [GO:0009272, PomBase:mah] synonym: "fungal-type cell wall biogenesis abolished" EXACT [PomBase:mah] is_a: FYPO:0000174 ! abnormal cell wall biogenesis is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0009272 ! fungal-type cell wall biogenesis relationship: towards GO:0009272 ! fungal-type cell wall biogenesis created_by: midori creation_date: 2014-08-06T15:28:10Z [Term] id: FYPO:0003640 name: abnormal adenylate kinase activity def: "A molecular function phenotype in which the observed rate of adenylate kinase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004017 ! adenylate kinase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004017 ! adenylate kinase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-08-06T15:31:08Z [Term] id: FYPO:0003641 name: increased adenylate kinase activity def: "A molecular function phenotype in which the observed rate of adenylate kinase activity is increased." [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0003640 ! abnormal adenylate kinase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0004017 ! adenylate kinase activity relationship: inheres_in GO:0004017 ! adenylate kinase activity created_by: midori creation_date: 2014-08-06T15:31:12Z [Term] id: FYPO:0003642 name: abnormal urease activity def: "A molecular function phenotype in which the observed rate of urease activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0009039 ! urease activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0009039 ! urease activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-08-06T15:33:13Z [Term] id: FYPO:0003643 name: decreased urease activity def: "A molecular function phenotype in which the observed rate of urease activity is decreased." [PomBase:mah] synonym: "reduced urease activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0003642 ! abnormal urease activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0009039 ! urease activity relationship: inheres_in GO:0009039 ! urease activity created_by: midori creation_date: 2014-08-06T15:33:18Z [Term] id: FYPO:0003644 name: RNA absent from cell during cellular response to vitamin B1 starvation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell is too low to detect during a cellular response to vitamin B1 starvation. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "RNA absent from cell during cellular response to thiamine starvation" EXACT [PomBase:mah] synonym: "RNA absent from cell during cellular response to vitamin B1 starvation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "RNA absent from cell during cellular response to vitamin B1 starvation during vegetative growth" EXACT [PomBase:mah] synonym: "transcripts absent from cell during cellular response to vitamin B1 starvation" EXACT [PomBase:vw] synonym: "undetectable RNA level during cellular response to vitamin B1 starvation" EXACT [PomBase:mah] is_a: FYPO:0001244 ! decreased RNA level during cellular response to vitamin B1 starvation is_a: FYPO:0003161 ! RNA absent from cell during vegetative growth intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0036225 ! cellular response to vitamin B1 starvation intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: during GO:0036225 ! cellular response to vitamin B1 starvation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-08-06T15:51:15Z [Term] id: FYPO:0003645 name: normal protein serine phosphorylation during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of serine residues of one or more specific proteins is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal peptidyl-serine phosphorylation during vegetative growth" EXACT [GO:0018105] synonym: "normal protein serine phosphorylation during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000776 ! normal protein phosphorylation during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0018105 ! peptidyl-serine phosphorylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0018105 ! peptidyl-serine phosphorylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-08-06T15:54:02Z [Term] id: FYPO:0003646 name: resistance to pyrithiamine def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of pyrithiamine than normal." [PomBase:mah] synonym: "resistance to pyrithiamine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to pyrithiamine during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to pyrithiamine" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:72290 ! pyrithiamine relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:72290 ! pyrithiamine created_by: midori creation_date: 2014-08-06T15:56:28Z [Term] id: FYPO:0003647 name: decreased sorbose import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of sorbose into the cell occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased sorbose import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased sorbose import during vegetative growth" EXACT [PomBase:mah] synonym: "decreased sorbose import into cell" EXACT [PomBase:al] synonym: "decreased sorbose uptake" EXACT [PomBase:mah] synonym: "reduced sorbose import" EXACT [PomBase:mah] is_a: FYPO:0001336 ! transport phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0001720 ! abnormal transport is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903258 ! sorbose import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903258 ! sorbose import into cell created_by: midori creation_date: 2014-08-06T16:07:43Z [Term] id: FYPO:0003648 name: abolished cell population growth on xanthine nitrogen source def: "A vegetative cell population growth phenotype in which a cell population does not grow in a medium containing xanthine as the nitrogen source." [PomBase:mah] comment: Use this term for a population of cells that does not grow with xanthine as the nitrogen source, but does grow using a different nitrogen source (a cell population that does not grow on any media would be considered inviable). Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "abolished growth on xanthine nitrogen source" BROAD [PomBase:mah] synonym: "abolished vegetative cell population growth on xanthine nitrogen source" EXACT [PomBase:mah] synonym: "abolished xanthine utilization" RELATED [PomBase:mah, PomBase:vw] synonym: "cell population growth on xanthine nitrogen source abolished" EXACT [PomBase:mah] is_a: FYPO:0001575 ! abolished vegetative cell population growth created_by: midori creation_date: 2014-08-06T16:10:31Z [Term] id: FYPO:0003649 name: abolished cell population growth on hypoxanthine nitrogen source def: "A vegetative cell population growth phenotype in which a cell population does not grow in a medium containing hypoxanthine as the nitrogen source." [PomBase:mah] comment: Use this term for a population of cells that does not grow with hypoxanthine as the nitrogen source, but does grow using a different nitrogen source (a cell population that does not grow on any media would be considered inviable). Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "abolished growth on hypoxanthine nitrogen source" BROAD [PomBase:mah] synonym: "abolished hypoxanthine utilization" RELATED [PomBase:mah, PomBase:vw] synonym: "abolished vegetative cell population growth on hypoxanthine nitrogen source" EXACT [PomBase:mah] synonym: "cell population growth on hypoxanthine nitrogen source abolished" EXACT [PomBase:mah] is_a: FYPO:0001575 ! abolished vegetative cell population growth created_by: midori creation_date: 2014-08-06T16:11:05Z [Term] id: FYPO:0003650 name: decreased protein level during cellular response to glucose starvation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during a cellular response to glucose starvation is lower than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein accumulation during cellular response to glucose starvation" RELATED [PomBase:mah] synonym: "decreased protein level during cellular response to glucose depletion" EXACT [PomBase:mah] synonym: "decreased protein level during cellular response to glucose deprivation" EXACT [PomBase:mah] synonym: "decreased protein level during cellular response to glucose starvation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein level during cellular response to glucose starvation during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein level during cellular response to glucose starvation" EXACT [PomBase:mah] is_a: FYPO:0001324 ! decreased protein level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0042149 ! cellular response to glucose starvation intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0042149 ! cellular response to glucose starvation relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2014-08-06T16:13:02Z [Term] id: FYPO:0003651 name: decreased protein level during cellular response to nitrosative stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during a cellular response to nitrosative stress is lower than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein accumulation during cellular response to nitrosative stress" RELATED [PomBase:mah] synonym: "decreased protein level during cellular response to nitrosative stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein level during cellular response to nitrosative stress during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein level during cellular response to nitrosative stress" EXACT [PomBase:mah] is_a: FYPO:0001324 ! decreased protein level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0071500 ! cellular response to nitrosative stress intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0071500 ! cellular response to nitrosative stress relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2014-08-06T16:15:31Z [Term] id: FYPO:0003652 name: abnormal transcription initiation from RNA polymerase III promoter def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription initiation from an RNA polymerase III promoter is abnormal." [GO:0006384, PomBase:mah] synonym: "abnormal transcription initiation from RNA polymerase III promoter during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal transcription initiation from RNA polymerase III promoter during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0004064 ! abnormal transcription intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006384 ! transcription initiation from RNA polymerase III promoter intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006384 ! transcription initiation from RNA polymerase III promoter relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-08-06T16:28:13Z [Term] id: FYPO:0003653 name: normal transcription elongation from RNA polymerase III promoter during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription elongation from an RNA polymerase III promoter occurs to a normal (i.e. indistinguishable from wild type) extent." [GO:0006385, PomBase:mah] synonym: "normal transcription elongation from RNA polymerase III promoter during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal transcription elongation from RNA polymerase III promoter during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001855 ! normal transcription during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006385 ! transcription elongation from RNA polymerase III promoter intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006385 ! transcription elongation from RNA polymerase III promoter relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-08-06T16:29:47Z [Term] id: FYPO:0003654 name: abolished cysteine synthase activity def: "A molecular function phenotype in which cysteine synthase activity is absent." [PomBase:mah] synonym: "cysteine synthase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0002754 ! abnormal cysteine synthase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0004124 ! cysteine synthase activity relationship: towards GO:0004124 ! cysteine synthase activity created_by: midori creation_date: 2014-08-06T16:33:28Z [Term] id: FYPO:0003655 name: abolished tRNA splicing def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the splicing tRNA substrates does not occur." [GO:0006388, PomBase:mah] synonym: "abolished tRNA splicing, via endonucleolytic cleavage and ligation" EXACT [GO:0006388] synonym: "tRNA splicing abolished" EXACT [PomBase:mah] is_a: FYPO:0001553 ! abnormal RNA processing is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0006388 ! tRNA splicing, via endonucleolytic cleavage and ligation relationship: towards GO:0006388 ! tRNA splicing, via endonucleolytic cleavage and ligation created_by: midori creation_date: 2014-08-12T11:08:53Z [Term] id: FYPO:0003656 name: sensitive to vanadate def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to vanadate ions. Cells stop growing (and may die) at a concentration of vanadate ions that allows wild type cells to grow." [PomBase:mah] comment: Also see 'sensitive to trisodium vanadate' (FYPO:0000718). synonym: "hypersensitive to vanadate" EXACT [PomBase:mah] synonym: "sensitive to vanadate during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to vanadate during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:30528 ! vanadium oxoanion relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:30528 ! vanadium oxoanion created_by: midori creation_date: 2014-08-12T11:15:42Z [Term] id: FYPO:0003657 name: protein mislocalized to endoplasmic reticulum def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a protein that is not normally found in the endoplasmic reticulum is observed there." [PomBase:mah] comment: Note that this term can be used to annotate any case where a protein is found in the ER in a mutant, but not in wild type. In some cases, there may be enough additional information to annotate to 'abnormal protein localization' (FYPO:0000443) or one of its descendants. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "ectopic protein localization to endoplasmic reticulum" EXACT [PomBase:vw] synonym: "protein mislocalised to endoplasmic reticulum" EXACT [PomBase:mah] synonym: "protein mislocalized to endoplasmic reticulum during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein mislocalized to endoplasmic reticulum during vegetative growth" EXACT [PomBase:mah] synonym: "protein mislocalized to ER" EXACT [PomBase:mah] is_a: FYPO:0000782 ! mislocalized protein during vegetative growth is_a: FYPO:0003777 ! abnormal protein localization to endoplasmic reticulum intersection_of: PATO:0000628 ! mislocalised intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CHEBI:36080 ! protein intersection_of: towards GO:0005783 ! endoplasmic reticulum relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CHEBI:36080 ! protein relationship: towards GO:0005783 ! endoplasmic reticulum created_by: midori creation_date: 2014-08-12T11:45:33Z [Term] id: FYPO:0003658 name: normal protein localization to Golgi membrane def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the membrane of any part of the Golgi apparatus is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to Golgi membrane" EXACT [PomBase:mah] synonym: "normal protein localization to Golgi membrane during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to Golgi membrane during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002332 ! normal protein localization to Golgi apparatus intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903292 ! protein localization to Golgi membrane intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903292 ! protein localization to Golgi membrane relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-08-12T11:47:44Z [Term] id: FYPO:0003659 name: abnormal mating type switching resulting in duplication or deletion in mating-type region def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which all or part of the mating-type region is duplicated or deleted upon mating type switching." [PMID:8290356, PomBase:mah] synonym: "abnormal mating type switching resulting in duplication or deletion in mating-type region during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal mating type switching resulting in duplication or deletion in mating-type region during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000468 ! abnormal mating type switching created_by: midori creation_date: 2014-08-12T11:57:50Z [Term] id: FYPO:0003660 name: decreased double-strand break repair def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which double-strand break repair occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased double-strand break repair during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased double-strand break repair during vegetative growth" EXACT [PomBase:mah] synonym: "reduced double-strand break repair" EXACT [PomBase:mah] is_a: FYPO:0000777 ! abnormal double-strand break repair is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006302 ! double-strand break repair relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006302 ! double-strand break repair created_by: midori creation_date: 2014-08-12T13:16:07Z [Term] id: FYPO:0003661 name: abnormal double-strand break repair via nonhomologous end joining def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of double-strand break repair via nonhomologous end joining (NHEJ) is abnormal. NHEJ is the repair of double-strand breaks in DNA in which the two broken ends are rejoined with little or no sequence complementarity." [GO:0006303, PomBase:mah] synonym: "abnormal double-strand break repair via nonhomologous end joining during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal double-strand break repair via nonhomologous end joining during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal NHEJ" EXACT [GO:0006303] synonym: "abnormal nonhomologous end joining" EXACT [PomBase:mah] is_a: FYPO:0000777 ! abnormal double-strand break repair intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006303 ! double-strand break repair via nonhomologous end joining intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006303 ! double-strand break repair via nonhomologous end joining relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-08-12T13:17:31Z [Term] id: FYPO:0003662 name: increased error-free double-strand break repair def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of double-strand break repair via an error-free mechanism, such as homologous recombination or break-induced replication, is increased." [PMID:10373582, PomBase:mah] comment: In wild-type fission yeast, double-strand breaks are usually repaired by error-prone non-homologous end joining. synonym: "increased error-free double-strand break repair during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased error-free double-strand break repair during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000777 ! abnormal double-strand break repair created_by: midori creation_date: 2014-08-12T13:25:53Z [Term] id: FYPO:0003663 name: abnormal RNA pyrophosphohydrolase activity def: "A molecular function phenotype in which the observed rate of RNA pyrophosphohydrolase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0034353 ! RNA pyrophosphohydrolase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0034353 ! RNA pyrophosphohydrolase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-08-12T13:31:50Z [Term] id: FYPO:0003664 name: abolished RNA pyrophosphohydrolase activity def: "A molecular function phenotype in which RNA pyrophosphohydrolase activity is absent." [PomBase:mah] synonym: "RNA pyrophosphohydrolase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0003663 ! abnormal RNA pyrophosphohydrolase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0034353 ! RNA pyrophosphohydrolase activity relationship: towards GO:0034353 ! RNA pyrophosphohydrolase activity created_by: midori creation_date: 2014-08-12T13:31:55Z [Term] id: FYPO:0003665 name: normal RNA pyrophosphohydrolase activity def: "A molecular function phenotype in which the observed rate of RNA pyrophosphohydrolase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0034353 ! RNA pyrophosphohydrolase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0034353 ! RNA pyrophosphohydrolase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-08-12T13:34:40Z [Term] id: FYPO:0003666 name: abnormal crossover junction endodeoxyribonuclease activity def: "A molecular function phenotype in which the observed rate of crossover junction endodeoxyribonuclease activity is abnormal." [PomBase:mah] is_a: FYPO:0002036 ! abnormal endodeoxyribonuclease activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0008821 ! crossover junction endodeoxyribonuclease activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0008821 ! crossover junction endodeoxyribonuclease activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-08-12T13:35:20Z [Term] id: FYPO:0003667 name: abolished crossover junction endodeoxyribonuclease activity def: "A molecular function phenotype in which crossover junction endodeoxyribonuclease activity is absent." [PomBase:mah] synonym: "crossover junction endodeoxyribonuclease activity abolished" EXACT [PomBase:mah] is_a: FYPO:0003164 ! abolished nuclease activity is_a: FYPO:0003666 ! abnormal crossover junction endodeoxyribonuclease activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0008821 ! crossover junction endodeoxyribonuclease activity relationship: towards GO:0008821 ! crossover junction endodeoxyribonuclease activity created_by: midori creation_date: 2014-08-12T13:35:24Z [Term] id: FYPO:0003668 name: resistance to caffeine during cellular response to hydroxyurea def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of caffeine than normal during a cellular response to hydroxyurea." [PomBase:mah] synonym: "resistance to caffeine during cellular response to HU" EXACT [PomBase:mah] synonym: "resistance to caffeine during cellular response to hydroxyurea during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to caffeine during cellular response to hydroxyurea during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to caffeine during cellular response to hydroxyurea" EXACT [PomBase:mah] is_a: FYPO:0000073 ! resistance to caffeine intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: during GO:0070301 ! cellular response to hydrogen peroxide intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:27732 ! caffeine relationship: during GO:0070301 ! cellular response to hydrogen peroxide relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:27732 ! caffeine created_by: midori creation_date: 2014-08-12T13:38:44Z [Term] id: FYPO:0003669 name: exon skipping def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which RNA splicing does not take place at a set of splice sites that are normally used, such that an exon is omitted from the mature RNA." [PMID:17130122, PomBase:mah] synonym: "increased exon skipping" EXACT [PomBase:mah] is_a: FYPO:0003467 ! altered splice site specificity created_by: midori creation_date: 2014-08-12T13:47:58Z [Term] id: FYPO:0003670 name: sensitive to mycophenolic acid def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to mycophenolic acid. Cells stop growing (and may die) at a concentration of mycophenolic acid that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to mycophenolic acid" EXACT [PomBase:mah] synonym: "sensitive to MPA" EXACT [PMID:17130122] synonym: "sensitive to mycophenolic acid during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to mycophenolic acid during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:168396 ! mycophenolic acid relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:168396 ! mycophenolic acid created_by: midori creation_date: 2014-08-12T13:48:57Z [Term] id: FYPO:0003671 name: abnormal ATP binding def: "A molecular function phenotype in which occurrence of ATP binding by a gene product (usually a protein) in a mutant is abnormal. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] comment: This term can mean that the mutated gene product itself binds ATP differently from wild type, or that a mutation in one gene affects ATP binding by a second gene product. When using this term, it is therefore recommended to note the specific protein(s) affected. is_a: FYPO:0000707 ! abnormal molecular function is_a: FYPO:0001092 ! binding phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0005524 ! ATP binding intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0005524 ! ATP binding relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-08-12T14:04:37Z [Term] id: FYPO:0003672 name: abolished ATP binding def: "A molecular function phenotype in which ATP binding by a gene product (usually a protein) in a mutant does not occur. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "ATP binding abolished" EXACT [PomBase:mah] is_a: FYPO:0003671 ! abnormal ATP binding is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0005524 ! ATP binding relationship: towards GO:0005524 ! ATP binding created_by: midori creation_date: 2014-08-12T14:04:46Z [Term] id: FYPO:0003673 name: normal ATP binding def: "A molecular function phenotype in which occurrence of ATP binding by a gene product (usually a protein) in a mutant is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000706 ! normal molecular function is_a: FYPO:0001092 ! binding phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0005524 ! ATP binding intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0005524 ! ATP binding relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-08-12T14:05:58Z [Term] id: FYPO:0003674 name: abolished ATPase activity def: "A molecular function phenotype in which ATPase activity is absent." [PomBase:mah] synonym: "ATPase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0001167 ! abnormal ATPase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0016887 ! ATPase activity relationship: towards GO:0016887 ! ATPase activity created_by: midori creation_date: 2014-08-12T14:07:00Z [Term] id: FYPO:0003675 name: increased 5.8S rRNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of the mature 5.8S rRNA measured in a cell is higher than normal." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased 5.8S rRNA accumulation" RELATED [PomBase:mah] synonym: "increased 5.8S rRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased 5.8S rRNA level during vegetative growth" EXACT [PomBase:mah] synonym: "increased 5.8S rRNA transcript level" EXACT [PomBase:vw] synonym: "increased mature 5.8S rRNA transcript" EXACT [PomBase:vw] is_a: FYPO:0000825 ! increased RNA level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards SO:0000375 ! rRNA_5_8S relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards SO:0000375 ! rRNA_5_8S created_by: midori creation_date: 2014-08-12T14:13:07Z [Term] id: FYPO:0003676 name: abnormal 5S RNA maturation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule is abnormal." [GO:0000481, PomBase:mah] synonym: "abnormal 5S RNA maturation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal 5S RNA maturation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal 5S RNA processing" EXACT [PomBase:al] synonym: "abnormal maturation of 5S rRNA" EXACT [GO:0000481] is_a: FYPO:0001553 ! abnormal RNA processing intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000481 ! maturation of 5S rRNA intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000481 ! maturation of 5S rRNA relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-08-12T14:30:13Z [Term] id: FYPO:0003677 name: branched, curved, elongated, multiseptate vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell forms one or more branches near a septum, is elongated, has more than one septum, and is curved along the long axis." [PomBase:mah] synonym: "branched, curved, elongated, multiseptate cell during vegetative growth" EXACT [PomBase:mah] synonym: "branched, curved, elongated, multiseptate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "branched, curved, long, multiseptate cell" EXACT [PomBase:vw] is_a: FYPO:0000134 ! branched, elongated, multiseptate cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000015 ! branched vegetative cell intersection_of: has_part FYPO:0000016 ! curved vegetative cell intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000118 ! multiseptate vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000015 ! branched vegetative cell relationship: has_part FYPO:0000016 ! curved vegetative cell relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000118 ! multiseptate vegetative cell created_by: midori creation_date: 2014-08-12T14:33:51Z [Term] id: FYPO:0003678 name: increased cellular doxorubicin level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of doxorubicin measured in a cell is higher than normal." [PomBase:mah] comment: Note that, because doxorubicin is not synthesized by fission yeast cells, the amount measured in a cell reflects uptake from the growth medium. synonym: "increased cellular doxorubicin level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular doxorubicin level during vegetative growth" EXACT [PomBase:mah] synonym: "increased doxorubicin accumulation" RELATED [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:28748 ! doxorubicin relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:28748 ! doxorubicin created_by: midori creation_date: 2014-08-12T14:48:51Z [Term] id: FYPO:0003679 name: sensitive to epirubicin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to epirubicin. Cells stop growing (and may die) at a concentration of epirubicin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to epirubicin" EXACT [PomBase:mah] synonym: "sensitive to 4'-epidoxorubicin" EXACT [CHEBI:47898] synonym: "sensitive to epirubicin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to epirubicin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:47898 ! 4'-epidoxorubicin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:47898 ! 4'-epidoxorubicin created_by: midori creation_date: 2014-08-12T14:50:22Z [Term] id: FYPO:0003680 name: normal growth on epirubicin def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing epirubicin." [PomBase:mah] synonym: "normal cell population growth in presence of epirubicin" EXACT [PomBase:mah] synonym: "normal cell population growth on 4'-epidoxorubicin" EXACT [CHEBI:47898, PomBase:mah] synonym: "normal cell population growth on epirubicin" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to epirubicin" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on epirubicin" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:47898 ! 4'-epidoxorubicin relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:47898 ! 4'-epidoxorubicin created_by: midori creation_date: 2014-08-12T14:52:07Z [Term] id: FYPO:0003681 name: decreased protein level at centromere outer repeat def: "A cell phenotype in which the amount of a protein found associated with chromatin at the centromere outer repeat regions is lower than normal when the cell is in the vegetative growth phase of the life cycle." [PMID:20018856, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein level at centromere otr" EXACT [PomBase:mah] synonym: "decreased protein level at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein level at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein level at centromeric outer repeat region" EXACT [PomBase:mah] synonym: "decreased protein level at pericentric region" RELATED [PomBase:mah] synonym: "decreased protein level at pericentromeric region" RELATED [PomBase:mah] synonym: "reduced protein level at centromere outer repeat" EXACT [PomBase:mah] is_a: FYPO:0001324 ! decreased protein level during vegetative growth created_by: midori creation_date: 2014-08-12T16:51:31Z [Term] id: FYPO:0003682 name: inviable after spore germination, without cell division, elongated multinucleate aseptate cell def: "A phenotype in which a spore germinates to produce an inviable cell that does not divide, is longer than normal, does not contain a septum, and contains more than one nucleus." [PomBase:mah] synonym: "essential; germinating spore, without cell division, elongated multinucleate aseptate cell" RELATED [PomBase:mah] synonym: "inviable after spore germination, multinucleate aseptate elongated cell" EXACT [PomBase:mah] synonym: "inviable after spore germination, undivided elongated multinucleate aseptate cell" EXACT [PomBase:mah] synonym: "inviable following spore germination, without cell division, elongated multinucleate aseptate cell" EXACT [PomBase:mah] synonym: "inviable germinated spore, without cell division, elongated multinucleate aseptate cell" EXACT [PomBase:mah] is_a: FYPO:0002912 ! inviable after spore germination, without cell division, elongated multinucleate cell created_by: midori creation_date: 2014-08-18T10:58:13Z [Term] id: FYPO:0003683 name: abnormal spliceosomal complex assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which any process of spliceosomal complex assembly is abnormal." [PomBase:mah] synonym: "abnormal spliceosomal complex assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal spliceosomal complex assembly during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal spliceosome assembly" BROAD [GO:0000245] is_a: FYPO:0003628 ! abnormal ribonucleoprotein complex assembly intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000245 ! spliceosomal complex assembly intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000245 ! spliceosomal complex assembly relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-08-18T11:02:56Z [Term] id: FYPO:0003684 name: altered level of macromolecular complex def: "A physical cellular phenotype in which the amount of any macromolecular complex present in a cell differs from wild type." [PomBase:mah] synonym: "abnormal level of macromolecular complex" EXACT [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: PATO:0002083 ! altered number of intersection_of: PATO:0002083 ! altered number of intersection_of: inheres_in CL:0000000 ! cell intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards GO:0032991 ! macromolecular complex relationship: inheres_in CL:0000000 ! cell relationship: qualifier PATO:0000460 ! abnormal relationship: towards GO:0032991 ! macromolecular complex created_by: midori creation_date: 2014-08-18T11:16:42Z [Term] id: FYPO:0003685 name: decreased U2/U5/U6 snRNP complex level def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells contain fewer U2/U5/U6 snRNP complexes than normal." [PomBase:mah] synonym: "decreased level of U2/U5/U6 snRNP complexes" RELATED [PomBase:al] synonym: "decreased U2-type post-mRNA release spliceosomal complex level" EXACT [GO:0071008, PomBase:mah] synonym: "decreased U2/U5/U6 snRNP complex level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased U2/U5/U6 snRNP complex level during vegetative growth" EXACT [PomBase:mah] synonym: "reduced U2/U5/U6 snRNP complex level" EXACT [PomBase:mah] synonym: "U2/U5/U6 snRNP complex present at decreased level" EXACT [PomBase:mah] is_a: FYPO:0003684 ! altered level of macromolecular complex is_a: PATO:0002001 ! has fewer parts of type intersection_of: PATO:0002001 ! has fewer parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0071008 ! U2-type post-mRNA release spliceosomal complex relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0071008 ! U2-type post-mRNA release spliceosomal complex created_by: midori creation_date: 2014-08-18T11:20:25Z [Term] id: FYPO:0003686 name: abnormal box C/D snoRNA 3'-end processing def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which formation of the mature 3' end of a box C/D snoRNA molecule is abnormal." [GO:0034472, PomBase:mah] synonym: "abnormal box C/D snoRNA 3'-end processing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal box C/D snoRNA 3'-end processing during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001553 ! abnormal RNA processing intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000495 ! box H/ACA snoRNA 3'-end processing intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000495 ! box H/ACA snoRNA 3'-end processing relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-08-18T11:41:49Z [Term] id: FYPO:0003687 name: abnormal protein localization to nucleolus def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleolus is abnormal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to nucleolus" EXACT [PomBase:mah] synonym: "abnormal protein localization to nucleolus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein localization to nucleolus during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001129 ! abnormal protein localization to nucleus during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1902570 ! protein localization to nucleolus intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1902570 ! protein localization to nucleolus relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-08-18T11:44:50Z [Term] id: FYPO:0003688 name: abolished protein localization to nucleolus def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleolus is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to nucleolus" EXACT [PomBase:mah] synonym: "abolished protein localization in nucleolus" EXACT [GO:1902570] synonym: "abolished protein localization to nucleolus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to nucleolus during vegetative growth" EXACT [PomBase:mah] synonym: "protein localization to nucleolus abolished" EXACT [PomBase:mah] is_a: FYPO:0001424 ! abolished protein localization to nucleus during vegetative growth is_a: FYPO:0003687 ! abnormal protein localization to nucleolus intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1902570 ! protein localization to nucleolus relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1902570 ! protein localization to nucleolus created_by: midori creation_date: 2014-08-18T11:46:45Z [Term] id: FYPO:0003689 name: abolished protein localization to nucleolus, with protein mislocalized to cytoplasm def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleolus is abolished, and the protein is present in the cytoplasm instead." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to nucleolus, with protein mislocalised to cytoplasm" EXACT [PomBase:mah] synonym: "abolished protein localization in nucleolus, with protein mislocalized to cytoplasm" EXACT [GO:1902570] synonym: "abolished protein localization to nucleolus, with protein mislocalized to cytoplasm during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to nucleolus, with protein mislocalized to cytoplasm, during vegetative growth" EXACT [PomBase:mah] synonym: "protein localization to nucleolus abolished, with protein mislocalized to cytoplasm" EXACT [PomBase:mah] is_a: FYPO:0002779 ! abolished protein localization to nucleus, with protein mislocalized to cytoplasm is_a: FYPO:0003688 ! abolished protein localization to nucleolus intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000783 ! protein mislocalized to cytoplasm intersection_of: towards GO:1902570 ! protein localization to nucleolus relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000783 ! protein mislocalized to cytoplasm relationship: towards GO:1902570 ! protein localization to nucleolus created_by: midori creation_date: 2014-08-18T11:46:48Z [Term] id: FYPO:0003690 name: abolished cell population growth on glycerol/ethanol carbon source def: "A vegetative cell population growth phenotype in which a cell population does not grow in a medium containing glycerol and ethanol as the carbon sources." [PomBase:mah] comment: Use this term for a population of cells that does not grow with glycerol and ethanol as the carbon sources, but does grow using a different carbon source (a cell population that does not grow on any media would be considered inviable). Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "abolished growth on glycerol/ethanol carbon source" BROAD [PomBase:mah] synonym: "abolished vegetative cell population growth on glycerol/ethanol carbon source" EXACT [PomBase:mah] synonym: "cell population growth on glycerol/ethanol carbon source abolished" EXACT [PomBase:mah] is_a: FYPO:0000442 ! decreased cell population growth on glycerol/ethanol carbon source is_a: FYPO:0001575 ! abolished vegetative cell population growth created_by: midori creation_date: 2014-08-18T11:51:55Z [Term] id: FYPO:0003691 name: increased cellular 5-demethoxyubiquinone-10 level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of 5-demethoxyubiquinone-10 ()2-decaprenyl-3-methyl-6-methoxy-1,4-benzoquinone, an intermediate in ubiquinone biosynthesis) measured in a cell is higher than normal." [PomBase:mah] synonym: "increased 5-demethoxyubiquinone-10 accumulation" RELATED [PomBase:mah] synonym: "increased cellular 2-decaprenyl-3-methyl-6-methoxy-1,4-benzoquinone level" EXACT [PMID:5166547] synonym: "increased cellular 5-demethoxyubiquinone-10 level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular 5-demethoxyubiquinone-10 level during vegetative growth" EXACT [PomBase:mah] synonym: "increased cellular demethoxyubiquinone-10 level" BROAD [PMID:18808426] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:50772 ! 2-decaprenyl-6-methoxy-3-methyl-1,4-benzoquinone relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:50772 ! 2-decaprenyl-6-methoxy-3-methyl-1,4-benzoquinone created_by: midori creation_date: 2014-08-18T11:55:27Z [Term] id: FYPO:0003692 name: increased protein phosphorylation during cellular response to oxidative stress def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a greater extent than normal during a cellular response to oxidative stress." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein phosphorylation during cellular response to oxidative stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein phosphorylation during cellular response to oxidative stress during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001038 ! increased protein phosphorylation during vegetative growth intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0034599 ! cellular response to oxidative stress intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0034599 ! cellular response to oxidative stress relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2014-08-18T12:10:32Z [Term] id: FYPO:0003693 name: sulfide absent from cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of (S2-, also called acid labile sulfide) measured in a cell is too low to detect." [PomBase:mah] synonym: "sulfide absent from cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sulfide absent from cell during vegetative growth" EXACT [PomBase:mah] synonym: "sulfide ions absent from cell" EXACT [PomBase:mah] synonym: "sulphide absent from cell" EXACT [PomBase:mah] is_a: FYPO:0001208 ! substance absent from cell during vegetative growth is_a: FYPO:0001289 ! decreased phospholipid level is_a: FYPO:0001412 ! decreased cellular sulfide level intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:15138 ! sulfide(2-) relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:15138 ! sulfide(2-) created_by: midori creation_date: 2014-08-18T12:11:58Z [Term] id: FYPO:0003694 name: decreased 18S rRNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of 18S ribosomal RNA measured in a cell is lower than normal." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "decreased 18S rRNA accumulation" RELATED [PomBase:mah] synonym: "decreased 18S rRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased 18S rRNA level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased 18S rRNA transcript level" EXACT [PomBase:vw] synonym: "decreased mature 18S rRNA transcript" EXACT [PomBase:vw] synonym: "reduced 18S rRNA level" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards SO:0000407 ! rRNA_18S relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards SO:0000407 ! rRNA_18S created_by: midori creation_date: 2014-08-18T12:19:48Z [Term] id: FYPO:0003695 name: decreased cytosolic small ribosomal subunit level def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells contain fewer free small ribosomal subunits in the cytosol than normal." [PomBase:mah] synonym: "cytosolic small ribosomal subunit present at decreased level" EXACT [PomBase:mah] synonym: "decreased 40S ribosomal subunit level" EXACT [PomBase:mah] synonym: "decreased cytosolic small ribosomal subunit level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cytosolic small ribosomal subunit level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased level of cytosolic small ribosomal subunits" RELATED [PomBase:al] synonym: "decreased small ribosomal subunit level" BROAD [PomBase:mah] synonym: "reduced cytosolic small ribosomal subunit level" EXACT [PomBase:mah] is_a: FYPO:0003684 ! altered level of macromolecular complex is_a: PATO:0002001 ! has fewer parts of type intersection_of: PATO:0002001 ! has fewer parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0022627 ! cytosolic small ribosomal subunit relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0022627 ! cytosolic small ribosomal subunit created_by: midori creation_date: 2014-08-18T12:24:03Z [Term] id: FYPO:0003696 name: increased cytosolic large ribosomal subunit level def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells contain more free large ribosomal subunits in the cytosol than normal." [PomBase:mah] synonym: "cytosolic large ribosomal subunit present at increased level" EXACT [PomBase:mah] synonym: "increased 60S ribosomal subunit level" EXACT [PomBase:mah] synonym: "increased cytosolic large ribosomal subunit level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cytosolic large ribosomal subunit level during vegetative growth" EXACT [PomBase:mah] synonym: "increased large ribosomal subunit level" BROAD [PomBase:mah] synonym: "increased level of cytosolic large ribosomal subunits" RELATED [PomBase:al] is_a: FYPO:0003684 ! altered level of macromolecular complex is_a: PATO:0002002 ! has extra parts of type intersection_of: PATO:0002002 ! has extra parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0022625 ! cytosolic large ribosomal subunit relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0022625 ! cytosolic large ribosomal subunit created_by: midori creation_date: 2014-08-18T12:26:02Z [Term] id: FYPO:0003697 name: cell wall invagination into cytoplasm def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which one or more extensions of the cell wall protrude into the cytoplasm. The cell wall extensions do not form a normal septum." [PMID:9211982, PomBase:mah] is_a: FYPO:0000351 ! abnormal cell wall morphology during vegetative growth created_by: midori creation_date: 2014-08-18T13:12:11Z [Term] id: FYPO:0003698 name: abnormal dense body present in nucleolus def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the nucleolus contains one or more spherical structures of great electron density that are not found in wild type cells." [PMID:9211982, PomBase:mah] is_a: FYPO:0000361 ! abnormal nucleolar morphology created_by: midori creation_date: 2014-08-18T13:14:45Z [Term] id: FYPO:0003699 name: snoRNA guided rRNA pseudouridine synthesis abolished at specific site def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the intramolecular conversion of uridine to pseudouridine does not occur at a specific site in an rRNA molecule that is normally modified." [GO:0000454, PMID:15716270, PomBase:mah] is_a: FYPO:0000370 ! abnormal RNA modification created_by: midori creation_date: 2014-08-18T13:16:39Z [Term] id: FYPO:0003700 name: increased snoRNA primary transcript level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of snoRNA primary transcripts measured in a cell is higher than normal." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "increased small nucleolar RNA primary transcript level" EXACT [PomBase:mah] synonym: "increased snoRNA primary transcript accumulation" RELATED [PomBase:mah] synonym: "increased snoRNA primary transcript level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased snoRNA primary transcript level during vegetative growth" EXACT [PomBase:mah] synonym: "increased snoRNA transcript level" BROAD [PomBase:vw] is_a: FYPO:0000825 ! increased RNA level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards SO:0000232 ! snoRNA_primary_transcript relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards SO:0000232 ! snoRNA_primary_transcript created_by: midori creation_date: 2014-08-18T13:33:23Z [Term] id: FYPO:0003701 name: poly(A)+ RNA-containing focus present in nucleus def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the nucleus contains one or more foci that are enriched in polyadenylated RNA and are not found in wild-type cells." [PMID:20129053, PomBase:mah] synonym: "poly(A)+ RNA-containing foci present in nucleus" EXACT [PomBase:mah] is_a: FYPO:0002403 ! abnormal nucleus created_by: midori creation_date: 2014-08-18T13:36:39Z [Term] id: FYPO:0003702 name: normal microtubule cytoskeleton morphology during vegetative growth def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of the microtubule cytoskeleton is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal microtubule cytoskeleton morphology during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001313 ! normal subcellular component during vegetative growth is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0015630 ! microtubule cytoskeleton intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0015630 ! microtubule cytoskeleton relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-08-18T14:06:19Z [Term] id: FYPO:0003703 name: abnormal histone deacetylase activity def: "A molecular function phenotype in which the observed rate of histone deacetylase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004407 ! histone deacetylase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004407 ! histone deacetylase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-08-18T14:08:46Z [Term] id: FYPO:0003704 name: decreased histone deacetylase activity def: "A molecular function phenotype in which the observed rate of histone deacetylase activity is decreased." [PomBase:mah] synonym: "reduced histone deacetylase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0003703 ! abnormal histone deacetylase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004407 ! histone deacetylase activity relationship: inheres_in GO:0004407 ! histone deacetylase activity created_by: midori creation_date: 2014-08-18T14:08:54Z [Term] id: FYPO:0003705 name: sensitive to trapoxin A def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to trapoxin A. Cells stop growing (and may die) at a concentration of trapoxin A that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to trapoxin A" EXACT [PomBase:mah] synonym: "sensitive to trapoxin A during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to trapoxin A during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:84057 ! trapoxin A relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:84057 ! trapoxin A created_by: midori creation_date: 2014-08-18T14:12:35Z [Term] id: FYPO:0003706 name: normal growth on K-252a def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing K-252a." [PomBase:mah] synonym: "normal cell population growth in presence of K-252a" EXACT [PomBase:mah] synonym: "normal cell population growth on K-252a" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to K-252a" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on K-252a" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:43616 ! K-252a relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:43616 ! K-252a created_by: midori creation_date: 2014-08-18T14:14:24Z [Term] id: FYPO:0003707 name: normal growth on valinomycin def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing valinomycin." [PomBase:mah] synonym: "normal cell population growth in presence of valinomycin" EXACT [PomBase:mah] synonym: "normal cell population growth on valinomycin" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to valinomycin" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on valinomycin" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:28545 ! valinomycin relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:28545 ! valinomycin created_by: midori creation_date: 2014-08-18T14:15:15Z [Term] id: FYPO:0003708 name: normal frequency of conjugation with h+ cells def: "A conjugation phenotype in which conjugation by a mutant with wild type h+ occurs at the same frequency as normal." [PomBase:mah] synonym: "normal conjugation with WT h+ cells" EXACT [PomBase:mah] synonym: "normal frequency of conjugation with h plus cells" EXACT [PomBase:mah] is_a: FYPO:0003797 ! normal conjugation frequency created_by: midori creation_date: 2014-08-18T14:24:51Z [Term] id: FYPO:0003709 name: decreased agglutination def: "A cell adhesion phenotype in which cells adhere to other cells of compatible mating type less strongly or to a lower extent than normal." [PomBase:mah] synonym: "decreased agglutination involved in conjugation with cellular fusion" EXACT [GO:0000752] synonym: "reduced agglutination" EXACT [PomBase:mah] is_a: FYPO:0001872 ! abnormal cell adhesion is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: towards GO:0000752 ! agglutination involved in conjugation with cellular fusion relationship: towards GO:0000752 ! agglutination involved in conjugation with cellular fusion created_by: midori creation_date: 2014-08-18T14:40:32Z [Term] id: FYPO:0003710 name: swollen pear-shaped vegetative cell def: "A cell morphology phenotype in which a cell is shaped in the form of a pear, and has a larger volume than normal, in the vegetative growth phase of the life cycle. One end is rounded, while the other resembles an end of a normal rod-shaped cell. The normally shaped end has the same diameter as a wild-type cell." [PomBase:mah] synonym: "swollen ice cream cone-shaped cell during vegetative growth" EXACT [PMID:2236039, PomBase:vw] synonym: "swollen pear-shaped cell during vegetative growth" EXACT [PomBase:mah] synonym: "swollen pear-shaped vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0001120 ! pear-shaped vegetative cell relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0001120 ! pear-shaped vegetative cell created_by: midori creation_date: 2014-08-18T16:10:38Z [Term] id: FYPO:0003711 name: lateral cortical nodes absent from cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the cell does not contain any detectable Skb1-containing lateral cortical nodes." [PMID:25009287, PomBase:mah] synonym: "absent lateral cortical nodes" EXACT [PomBase:mah] synonym: "lateral cortical nodes absent from cell during vegetative growth" EXACT [PomBase:mah] synonym: "Skb1-containing cortical nodes absent from cell" EXACT [PMID:25009287] is_a: FYPO:0003684 ! altered level of macromolecular complex is_a: PATO:0002000 ! lacks all parts of type intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards GO:1990463 ! lateral cortical node relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards GO:1990463 ! lateral cortical node created_by: midori creation_date: 2014-08-20T11:16:31Z [Term] id: FYPO:0003712 name: lateral cortical nodes present in greater numbers def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells contain more Skb1-containing lateral cortical nodes than normal." [PomBase:mah] synonym: "additional lateral cortical nodes present during vegetative growth" EXACT [PomBase:mah] synonym: "extra lateral cortical nodes during vegetative growth" EXACT [PomBase:mah] synonym: "lateral cortical nodes present in greater numbers during mitotic cell cycle" RELATED [PomBase:mah] synonym: "lateral cortical nodes present in greater numbers during vegetative growth" EXACT [PomBase:mah] synonym: "Skb1-containing cortical nodes present in greater numbers" EXACT [PMID:25009287] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: PATO:0002002 ! has extra parts of type intersection_of: PATO:0002002 ! has extra parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1990463 ! lateral cortical node relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1990463 ! lateral cortical node created_by: midori creation_date: 2014-08-20T11:20:38Z [Term] id: FYPO:0003713 name: abolished protein localization to lateral cortical node def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to Skb1-containing lateral cortical nodes does not occur." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to lateral cortical node" EXACT [PomBase:mah] synonym: "abolished protein localisation to Skb1-containing cortical node" EXACT [GO:1990463, PomBase:mah] synonym: "abolished protein localization to lateral cortical node during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to lateral cortical node during vegetative growth" EXACT [PomBase:mah] synonym: "protein absent from lateral cortical node" RELATED [PomBase:mah] synonym: "protein localization to lateral cortical node abolished" EXACT [PomBase:mah] is_a: FYPO:0000930 ! abolished protein localization to cell cortex intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1903360 ! protein localization to lateral cortical node relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1903360 ! protein localization to lateral cortical node created_by: midori creation_date: 2014-08-20T11:30:44Z [Term] id: FYPO:0003714 name: abolished protein localization to lateral cortical node, with protein mislocalized to cytoplasm def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to Skb1-containing lateral cortical nodes is abolished, and the protein is present in the cytoplasm instead." [PMID:25009287, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to lateral cortical node, with protein mislocalised to cytoplasm" EXACT [PomBase:mah] synonym: "abolished protein localization to lateral cortical node, with protein mislocalized to cytoplasm, during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to lateral cortical node, with protein mislocalized to cytoplasm, during vegetative growth" EXACT [PomBase:mah] synonym: "protein localization to lateral cortical node abolished, with protein mislocalized to cytoplasm" EXACT [PomBase:mah] is_a: FYPO:0003713 ! abolished protein localization to lateral cortical node intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000783 ! protein mislocalized to cytoplasm intersection_of: towards GO:1903360 ! protein localization to lateral cortical node relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000783 ! protein mislocalized to cytoplasm relationship: towards GO:1903360 ! protein localization to lateral cortical node created_by: midori creation_date: 2014-08-20T11:30:55Z [Term] id: FYPO:0003715 name: abolished protein localization to lateral cortical node, with protein distributed in plasma membrane or cortex def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to Skb1-containing lateral cortical nodes is abolished, and the protein is instead detected distributed throughout the plasma membrane and/or cell cortex." [PMID:25009287, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to lateral cortical node, with protein distributed in plasma membrane or cortex" EXACT [PomBase:mah] synonym: "abolished protein localization to lateral cortical node, with protein distributed in cell cortex" NARROW [PomBase:mah] synonym: "abolished protein localization to lateral cortical node, with protein distributed in plasma membrane" NARROW [PomBase:mah] synonym: "abolished protein localization to lateral cortical node, with protein distributed in plasma membrane or cortex, during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to lateral cortical node, with protein distributed in plasma membrane or cortex, during vegetative growth" EXACT [PomBase:mah] synonym: "protein localization to lateral cortical node abolished, with protein distributed in plasma membrane or cortex" EXACT [PomBase:mah] is_a: FYPO:0003713 ! abolished protein localization to lateral cortical node created_by: midori creation_date: 2014-08-20T11:34:04Z [Term] id: FYPO:0003716 name: abolished protein localization to lateral cortical node, with protein mislocalized to nucleus def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to Skb1-containing lateral cortical nodes is abolished, and the protein is present in the nucleus instead." [PMID:25009287, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to lateral cortical node, with protein mislocalised to nucleus" EXACT [PomBase:mah] synonym: "abolished protein localization to lateral cortical node, with protein mislocalized to nucleus, during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to lateral cortical node, with protein mislocalized to nucleus, during vegetative growth" EXACT [PomBase:mah] synonym: "protein localization to lateral cortical node abolished, with protein mislocalized to nucleus" EXACT [PomBase:mah] is_a: FYPO:0003713 ! abolished protein localization to lateral cortical node intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000784 ! protein mislocalized to nucleus during vegetative growth intersection_of: towards GO:1903360 ! protein localization to lateral cortical node relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000784 ! protein mislocalized to nucleus during vegetative growth relationship: towards GO:1903360 ! protein localization to lateral cortical node created_by: midori creation_date: 2014-08-20T11:37:47Z [Term] id: FYPO:0003717 name: normal actin cytoskeleton morphology during vegetative growth def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of the actin cytoskeleton is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal actin cytoskeleton morphology during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0004739 ! normal actin cytoskeleton during vegetative growth is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0015629 ! actin cytoskeleton intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0015629 ! actin cytoskeleton relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-08-20T11:55:05Z [Term] id: FYPO:0003718 name: sensitive to tributyltin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to tributyltin. Cells stop growing (and may die) at a concentration of tributyltin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to tributyltin" EXACT [PomBase:mah] synonym: "sensitive to tributylstannane" EXACT [CHEBI:27086, PomBase:mah] synonym: "sensitive to tributyltin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to tributyltin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:27086 ! tributylstannane relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:27086 ! tributylstannane created_by: midori creation_date: 2014-08-20T12:02:11Z [Term] id: FYPO:0003719 name: normal growth on tributyltin def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing tributyltin." [PomBase:mah] synonym: "normal cell population growth in presence of tributyltin" EXACT [PomBase:mah] synonym: "normal cell population growth on tributylstannane" EXACT [CHEBI:27086] synonym: "normal cell population growth on tributyltin" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to tributyltin" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on tributyltin" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:27086 ! tributylstannane relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:27086 ! tributylstannane created_by: midori creation_date: 2014-08-20T12:03:33Z [Term] id: FYPO:0003720 name: snoRNA guided rRNA 2'-O-methylation abolished at specific site def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the 2'-O-methylation of a nucleotide residue does not occur at a specific site in an rRNA molecule that is normally modified." [GO:0000452, PMID:17222800, PomBase:mah] is_a: FYPO:0000370 ! abnormal RNA modification created_by: midori creation_date: 2014-08-20T13:59:03Z [Term] id: FYPO:0003721 name: normal growth on G418 def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing G418." [PomBase:mah] synonym: "normal cell population growth in presence of G418" EXACT [PomBase:mah] synonym: "normal cell population growth on G418" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cell population growth on Geneticin" EXACT [CHEBI:42768, PomBase:mah] synonym: "normal cellular response to G418" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on G418" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:42768 ! geneticin relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:42768 ! geneticin created_by: midori creation_date: 2014-08-20T14:00:57Z [Term] id: FYPO:0003722 name: decreased tRNA 5'-leader removal def: "A cellular process phenotype in which the removal of leader sequences to generate the mature 5'-end of a tRNA occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased tRNA 5'-leader removal during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased tRNA 5'-leader removal during vegetative growth" EXACT [PomBase:mah] synonym: "reduced tRNA 5'-leader removal" RELATED [PomBase:mah] is_a: FYPO:0001553 ! abnormal RNA processing created_by: midori creation_date: 2014-08-20T14:06:00Z [Term] id: FYPO:0003723 name: abnormal bis(5'-adenosyl)-hexaphosphatase activity def: "A molecular function phenotype in which the observed rate of bis(5'-adenosyl)-hexaphosphatase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0034431 ! bis(5'-adenosyl)-hexaphosphatase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0034431 ! bis(5'-adenosyl)-hexaphosphatase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-08-20T15:52:14Z [Term] id: FYPO:0003724 name: decreased bis(5'-adenosyl)-hexaphosphatase activity def: "A molecular function phenotype in which the observed rate of bis(5'-adenosyl)-hexaphosphatase activity is decreased." [PomBase:mah] synonym: "reduced bis(5'-adenosyl)-hexaphosphatase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0003723 ! abnormal bis(5'-adenosyl)-hexaphosphatase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0034431 ! bis(5'-adenosyl)-hexaphosphatase activity relationship: inheres_in GO:0034431 ! bis(5'-adenosyl)-hexaphosphatase activity created_by: midori creation_date: 2014-08-20T15:52:20Z [Term] id: FYPO:0003725 name: increased bis(5'-adenosyl)-hexaphosphatase activity def: "A molecular function phenotype in which the observed rate of bis(5'-adenosyl)-hexaphosphatase activity is increased." [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0003723 ! abnormal bis(5'-adenosyl)-hexaphosphatase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0034431 ! bis(5'-adenosyl)-hexaphosphatase activity relationship: inheres_in GO:0034431 ! bis(5'-adenosyl)-hexaphosphatase activity created_by: midori creation_date: 2014-08-20T15:52:32Z [Term] id: FYPO:0003726 name: increased cellular inositol pentakisphosphate level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of any myo-inositol pentakisphosphate measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular inositol pentakisphosphate level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular inositol pentakisphosphate level during vegetative growth" EXACT [PomBase:mah] synonym: "increased cellular myo-inositol pentakisphosphate level" EXACT [CHEBI:25447, PomBase:al] synonym: "increased inositol pentakisphosphate accumulation" RELATED [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:25447 ! myo-inositol pentakisphosphate relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:25447 ! myo-inositol pentakisphosphate created_by: midori creation_date: 2014-08-20T15:55:52Z [Term] id: FYPO:0003727 name: galactose absent from cell wall glycoprotein glycan def: "A phenotype in which the glycan moiety of a glycoprotein in the cell wall does not contain galactose residues. In wild-type cells, glycoprotein glycans contain mannose and galactose residues in a 1:1.2 ratio, and the galactose residues are connected by alpha-1,2 linkages." [PMID:11378902, PMID:9125114, PomBase:mah] comment: Note that this term is not a child of 'galactose absent from cell wall' (FYPO:0002629) because the cell wall may contain galactose residues in glycans that are not part of glycosylated proteins. synonym: "abolished galactosylation of cell surface proteins" RELATED [PomBase:vw] synonym: "alpha 1,2-linked galactose residues absent from cell wall glycoprotein" EXACT [PMID:9125114, PomBase:vw] synonym: "galactose absent from glycoprotein glycan in cell wall" EXACT [PomBase:mah] is_a: FYPO:0002628 ! decreased level of substance in cell wall is_a: FYPO:0003291 ! galactose absent from glycoprotein glycan created_by: midori creation_date: 2014-08-27T10:38:02Z [Term] id: FYPO:0003728 name: abolished protein galactosylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the galactosylation of one or more specific proteins, or of specific protein sites, does not occur. Protein galactosylation is the addition of a galactose residue to a protein amino acid." [GO:0042125, PomBase:mah] synonym: "abolished protein galactosylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein galactosylation during vegetative growth" EXACT [PomBase:mah] synonym: "protein galactosylation abolished" EXACT [PomBase:mah] is_a: FYPO:0000544 ! abolished protein modification during vegetative growth is_a: FYPO:0001910 ! abnormal protein glycosylation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0006486 ! protein glycosylation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_output FYPO:0003291 ! galactose absent from glycoprotein glycan relationship: towards GO:0006486 ! protein glycosylation created_by: midori creation_date: 2014-08-27T10:46:38Z [Term] id: FYPO:0003729 name: protein mislocalized to nuclear periphery def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a protein that is not normally found in the nuclear periphery is observed there." [PomBase:mah] comment: Note that this term can be used to annotate any case where a protein is found in the nuclear periphery in a mutant, but not in wild type. In some cases, there may be enough additional information to annotate to 'abnormal protein localization' (FYPO:0000443) or one of its descendants. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "ectopic protein localization to nuclear periphery" EXACT [PomBase:vw] synonym: "protein mislocalised to nuclear periphery" EXACT [PomBase:mah] synonym: "protein mislocalised to nuclear periphery during vegetative growth" EXACT [PomBase:mah] synonym: "protein mislocalized to nuclear periphery during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000782 ! mislocalized protein during vegetative growth intersection_of: PATO:0000628 ! mislocalised intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CHEBI:36080 ! protein intersection_of: towards GO:0034399 ! nuclear periphery relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CHEBI:36080 ! protein relationship: towards GO:0034399 ! nuclear periphery created_by: midori creation_date: 2014-08-27T14:08:07Z [Term] id: FYPO:0003730 name: abolished cell population growth on galactose carbon source def: "A vegetative cell population growth phenotype in which a cell population does not grow in a medium containing galactose as the carbon source." [PomBase:mah] comment: Use this term for a population of cells that does not grow with galactose as the carbon source, but does grow using a different carbon source (a cell population that does not grow on any media would be considered inviable). Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "abolished galactose utilization" RELATED [PomBase:mah, PomBase:vw] synonym: "abolished growth on galactose carbon source" BROAD [PomBase:mah] synonym: "abolished vegetative cell population growth on galactose carbon source" EXACT [PomBase:mah] synonym: "cell population growth on galactose carbon source abolished" EXACT [PomBase:mah] is_a: FYPO:0000251 ! decreased cell population growth on galactose carbon source is_a: FYPO:0001575 ! abolished vegetative cell population growth intersection_of: FYPO:0001575 ! abolished vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:12936 ! D-galactose relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:12936 ! D-galactose created_by: midori creation_date: 2014-08-27T14:23:02Z [Term] id: FYPO:0003731 name: normal growth on galactose carbon source def: "A vegetative cell population growth phenotype in which cells grow normally in a medium containing galactose as the carbon source." [PomBase:mah] synonym: "normal cell population growth on galactose carbon source" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal vegetative cell population growth on galactose carbon source" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0000047 ! normal cell population growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:12936 ! D-galactose relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:12936 ! D-galactose created_by: midori creation_date: 2014-08-27T14:24:18Z [Term] id: FYPO:0003732 name: respiratory chain complex IV absent from cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the cell does not contain any detectable respiratory chain complex IV in the mitochondria." [PMID:16911509, PomBase:mah] synonym: "absent respiratory chain complex IV" EXACT [PomBase:mah] synonym: "mitochondrial respiratory chain complex IV absent from cell" EXACT [GO:0005751] synonym: "respiratory chain complex IV absent from cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "respiratory chain complex IV absent from cell during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003684 ! altered level of macromolecular complex is_a: PATO:0002000 ! lacks all parts of type intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards GO:0005751 ! mitochondrial respiratory chain complex IV relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards GO:0005751 ! mitochondrial respiratory chain complex IV created_by: midori creation_date: 2014-08-27T14:27:19Z [Term] id: FYPO:0003733 name: abnormal alcohol dehydrogenase activity def: "A molecular function phenotype in which the observed rate of alcohol dehydrogenase activity is abnormal." [PomBase:mah] synonym: "alcohol dehydrogenase (NAD) activity" EXACT [GO:0004022] is_a: FYPO:0000689 ! abnormal oxidoreductase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004022 ! alcohol dehydrogenase (NAD) activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004022 ! alcohol dehydrogenase (NAD) activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-08-27T14:45:07Z [Term] id: FYPO:0003734 name: decreased alcohol dehydrogenase activity def: "A molecular function phenotype in which the observed rate of alcohol dehydrogenase activity is decreased." [PomBase:mah] synonym: "decreased alcohol dehydrogenase (NAD) activity" EXACT [GO:0004022] synonym: "reduced alcohol dehydrogenase activity" EXACT [PomBase:mah] is_a: FYPO:0000690 ! decreased oxidoreductase activity is_a: FYPO:0003733 ! abnormal alcohol dehydrogenase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004022 ! alcohol dehydrogenase (NAD) activity relationship: inheres_in GO:0004022 ! alcohol dehydrogenase (NAD) activity created_by: midori creation_date: 2014-08-27T14:45:18Z [Term] id: FYPO:0003735 name: altered DNA binding specificity def: "A molecular function phenotype in which a gene product that normally binds to a specific DNA sequence instead binds to a different sequence when a gene is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [PMID:7651412, PomBase:mah] synonym: "abnormal DNA binding specificity" EXACT [PomBase:mah] is_a: FYPO:0000656 ! abnormal DNA binding created_by: midori creation_date: 2014-08-27T15:09:29Z [Term] id: FYPO:0003736 name: normal mitotic index def: "A cell population phenotype in which the mitotic index is normal (i.e. indistinguishable from wild type). The mitotic index is the proportion of the population undergoing mitosis at any given time." [PomBase:mah, PomBase:vw] is_a: FYPO:0000003 ! cell population phenotype is_a: FYPO:0000257 ! normal phenotype created_by: midori creation_date: 2014-08-27T15:16:49Z [Term] id: FYPO:0003737 name: delayed protein phosphorylation during mitotic G2 phase def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, begins later than normal during G2 phase of the mitotic cell cycle." [PomBase:mah] synonym: "delayed protein phosphorylation during mitotic G2 phase during vegetative growth" EXACT [PomBase:mah] synonym: "delayed protein phosphorylation during mitotic G2-phase" EXACT [PomBase:vw] synonym: "delayed protein/peptide phosphorylation during mitotic G2 phase" EXACT [PomBase:mah] is_a: FYPO:0002830 ! delayed protein phosphorylation during vegetative growth intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0000085 ! mitotic G2 phase intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0000085 ! mitotic G2 phase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2014-08-27T15:30:55Z [Term] id: FYPO:0003738 name: abnormal mitotic cell cycle arrest with condensed chromosomes def: "A cellular process phenotype in which progression through the mitotic cell cycle is arrested when cells have condensed chromosomes, but show no other signs of having entered mitosis or M phase, under conditions where arrest does not normally occur." [PomBase:mah] comment: Note that in wild-type cells, chromosomes are condensed only in M phase. This term can be used for mutants in which chromosomes are condensed but other normal features of M phase cells are not observed. synonym: "abnormal mitotic cell cycle arrest with condensed chromosomes during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000502 ! abnormally arrested mitotic cell cycle progression intersection_of: FYPO:0000407 ! abnormally arrested cell cycle progression intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: preceded_by GO:0007076 ! mitotic chromosome condensation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: preceded_by GO:0007076 ! mitotic chromosome condensation created_by: midori creation_date: 2014-08-27T15:31:53Z [Term] id: FYPO:0003739 name: decreased DNA replication origin binding def: "A molecular function phenotype in which occurrence of DNA binding at a replication origin by a gene product is decreased, when a gene or the bound DNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "decreased origin binding" EXACT [PomBase:mah] synonym: "reduced DNA replication origin binding" EXACT [PomBase:mah] is_a: FYPO:0000658 ! decreased DNA binding intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0003688 ! DNA replication origin binding relationship: inheres_in GO:0003688 ! DNA replication origin binding created_by: midori creation_date: 2014-08-27T16:12:31Z [Term] id: FYPO:0003740 name: decreased CENP-A containing nucleosome assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the formation of nucleosomes containing the histone H3 variant CenH3 (also called CENP-A; Cnp1 in S. pombe) occurs to a lower extent than normal. CENP-A-containing nucleosomes are normally assembled into chromatin around centromeres, encompassing the central core and centromeric inner repeat regions." [GO:0034080, PomBase:mah] synonym: "decreased CenH3-containing nucleosome assembly at centromere" RELATED [GO:0034080] synonym: "decreased CENP-A containing nucleosome assembly at centromere" EXACT [PomBase:mah] synonym: "decreased CENP-A containing nucleosome assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased CENP-A containing nucleosome assembly during vegetative growth" EXACT [PomBase:mah] synonym: "decreased CENP-A deposition" RELATED [GO:0034080] synonym: "decreased CENP-A loading" RELATED [GO:0034080] synonym: "decreased centromere-specific histone exchange" EXACT [GO:0034080] synonym: "decreased centromere-specific nucleosome assembly" EXACT [GO:0034080] synonym: "decreased centromeric DNA replication-independent nucleosome assembly" EXACT [GO:0034080] synonym: "decreased DNA replication-independent nucleosome assembly at centromere" EXACT [GO:0034080] synonym: "reduced CENP-A containing nucleosome assembly" EXACT [PomBase:mah] is_a: FYPO:0003409 ! abnormal CENP-A containing nucleosome assembly is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034080 ! CENP-A containing nucleosome assembly relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034080 ! CENP-A containing nucleosome assembly created_by: midori creation_date: 2014-08-27T16:19:51Z [Term] id: FYPO:0003741 name: abolished cytochrome-c oxidase activity def: "A molecular function phenotype in which cytochrome-c oxidase activity is absent." [PomBase:mah] synonym: "cytochrome-c oxidase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0001937 ! abnormal cytochrome-c oxidase activity is_a: FYPO:0002117 ! abolished transporter activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0004129 ! cytochrome-c oxidase activity relationship: towards GO:0004129 ! cytochrome-c oxidase activity created_by: midori creation_date: 2014-09-01T13:45:17Z [Term] id: FYPO:0003742 name: inviable after spore germination, multiple cell divisions, unequal chromosome segregation def: "A phenotype in which a spore germinates to produce a cell that undergoes two or more rounds of cell division during which chromosomes segregate unequally, and then dies." [PomBase:al, PomBase:mah] synonym: "essential; germinating spore, multiple cell divisions, unequal chromosome segregation" RELATED [PomBase:mah] synonym: "inviable following spore germination, multiple cell divisions, unequal chromosome segregation" EXACT [PomBase:mah] synonym: "inviable germinated spore, multiple cell divisions, unequal chromosome segregation" EXACT [PomBase:mah] is_a: FYPO:0002430 ! inviable after spore germination, multiple cell divisions created_by: midori creation_date: 2014-09-01T13:52:53Z [Term] id: FYPO:0003743 name: decreased cell population growth during glucose limitation def: "A cell growth phenotype in which cell population growth is decreased relative to normal under conditions of glucose limitation, such as in a medium that contains a low level of glucose and no other carbon source." [PomBase:mah] comment: Use this term if you have assayed growth of cells exposed to glucose limitation in culture. Note that glucose limitation differs from glucose starvation in that starvation results from complete absence of glucose, whereas limitation results from a shift from high to low glucose levels. Glucose concentrations below about 4.4 mM (0.08%) are typically regarded as limiting. synonym: "decreased cell population growth in response to glucose limitation" EXACT [PomBase:mah] synonym: "hypersensitive to glucose limitation" RELATED [PomBase:mah] synonym: "reduced cell population growth during glucose limitation" RELATED [PomBase:mah] synonym: "sensitive to glucose limitation" RELATED [PomBase:vw] synonym: "slow cell population growth during glucose limitation" NARROW [PomBase:mah] is_a: FYPO:0000046 ! decreased cell population growth created_by: midori creation_date: 2014-09-08T11:52:09Z [Term] id: FYPO:0003744 name: abolished protein localization to centromeric chromatin def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to centromeric chromatin is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to centromeric chromatin during vegetative growth" EXACT [PomBase:mah] synonym: "abolished protein localization to centromeric chromatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to chromatin at centromere" EXACT [PomBase:mah] synonym: "protein localization to centromeric chromatin during vegetative growth abolished" EXACT [PomBase:mah] is_a: FYPO:0000634 ! abolished protein localization to centromere is_a: FYPO:0001508 ! abolished protein localization to chromatin during vegetative growth intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: occurs_at SO:0001795 ! regional_centromere intersection_of: towards GO:0071168 ! protein localization to chromatin relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: occurs_at SO:0001795 ! regional_centromere relationship: towards GO:0071168 ! protein localization to chromatin created_by: midori creation_date: 2014-09-01T14:23:24Z [Term] id: FYPO:0003745 name: increased histone H3 acetylation at centromere central core def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone H3 acetylation occurs to a greater extent than normal in the central core of the centromeric regions." [PomBase:mah] synonym: "increased histone H3 acetylation at centromere central core during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H3 acetylation at centromere central core during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002363 ! increased histone H3 acetylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0043966 ! histone H3 acetylation intersection_of: occurs_at SO:0001796 ! regional_centromere_central_core relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0043966 ! histone H3 acetylation relationship: occurs_at SO:0001796 ! regional_centromere_central_core created_by: midori creation_date: 2014-09-01T14:32:10Z [Term] id: FYPO:0003746 name: increased histone H3-K9 methylation at heterochromatin island def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which methylation of lysine at position 9 of histone H3 in heterochromatin islands occurs to a greater extent than normal." [PomBase:mah] synonym: "increased histone H3 K9 methylation at heterochromatin island" EXACT [GO:0051567, PomBase:mah] synonym: "increased histone H3-K9 methylation at heterochromatin island during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H3-K9 methylation at heterochromatin island during vegetative growth" EXACT [PomBase:mah] synonym: "increased histone H3K9me at heterochromatin island" EXACT [GO:0051567, PomBase:mah] synonym: "increased histone lysine H3 K9 methylation at heterochromatin island" EXACT [GO:0051567, PomBase:mah] is_a: FYPO:0000871 ! increased histone H3-K9 methylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051567 ! histone H3-K9 methylation intersection_of: occurs_at GO:1990342 ! heterochromatin island relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051567 ! histone H3-K9 methylation relationship: occurs_at GO:1990342 ! heterochromatin island created_by: midori creation_date: 2014-09-01T14:49:33Z [Term] id: FYPO:0003747 name: normal level of DSR-containing meiosis gene RNA during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more RNAs that are normally expressed during meiosis, and that contain determinant of selective removal (DSR) sequences, measured in a cell is normal (i.e. indistinguishable from wild type)." [PMID:24713849, PomBase:mah] synonym: "normal DSR-containing meiosis gene RNA accumulation during vegetative growth" RELATED [PomBase:mah] synonym: "normal level of DSR-containing meiosis gene RNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal level of DSR-containing meiosis gene transcripts during vegetative growth" EXACT [PomBase:vw] is_a: FYPO:0001317 ! normal RNA level during vegetative growth created_by: midori creation_date: 2014-09-01T14:54:07Z [Term] id: FYPO:0003748 name: abnormal protein localization to nuclear body def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to nuclear bodies is abnormal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to nuclear body" EXACT [PomBase:mah] synonym: "abnormal protein localization to nuclear body during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein localization to nuclear body during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002529 ! abnormal protein localization to nucleoplasm intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1903405 ! protein localization to nuclear body intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1903405 ! protein localization to nuclear body relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-09-01T15:15:14Z [Term] id: FYPO:0003749 name: abolished positive regulation of m7G(5')pppN diphosphatase activity def: "A regulation phenotype observed in the vegetative growth phase of the life cycle in which positive regulation of m7G(5')pppN diphosphatase activity does not occur." [PMID:22323607, PomBase:mah] synonym: "positive regulation of m7G(5')pppN diphosphatase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000682 ! abnormal regulation of molecular function is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1903399 ! positive regulation of m7G(5')pppN diphosphatase activity relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1903399 ! positive regulation of m7G(5')pppN diphosphatase activity created_by: midori creation_date: 2014-09-01T15:29:36Z [Term] id: FYPO:0003750 name: normal nuclear pore density def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which a cell contains a normal number of nuclear pore complexes." [PMID:9372936, PomBase:mah] synonym: "normal nuclear pore density during mitotic cell cycle" EXACT [PomBase:mah] synonym: "normal nuclear pore density during vegetative growth" EXACT [PomBase:mah] synonym: "nuclear pore complexes present in normal number" EXACT [GO:0005643] synonym: "nuclear pores present in normal number" EXACT [PomBase:mah] is_a: FYPO:0001313 ! normal subcellular component during vegetative growth is_a: PATO:0001905 ! has normal numbers of parts of type intersection_of: PATO:0001905 ! has normal numbers of parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005643 ! nuclear pore relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005643 ! nuclear pore created_by: midori creation_date: 2014-09-01T16:03:26Z [Term] id: FYPO:0003751 name: normal nuclear envelope morphology def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of all or part of the nuclear envelope is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: Note that an abnormal nuclear envelope organization process may, but does not necessarily, result in abnormal nuclear envelope morphology. synonym: "normal nuclear envelope morphology during mitotic cell cycle" EXACT [PomBase:mah] synonym: "normal nuclear envelope morphology during vegetative growth" EXACT [PomBase:mah] synonym: "normal nuclear membrane morphology" NARROW [PomBase:mah] is_a: FYPO:0001313 ! normal subcellular component during vegetative growth is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005635 ! nuclear envelope intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005635 ! nuclear envelope relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-09-01T16:07:55Z [Term] id: FYPO:0003752 name: increased total nuclear polyadenylated mRNA level during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the total amount of polyadenylated messenger RNA (mRNA) measured in the nucleus is higher than normal." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "increased level of bulk nuclear polyadenylated mRNA during vegetative growth" EXACT [PomBase:mah] synonym: "increased level of total nuclear polyadenylated mRNA during vegetative growth" EXACT [PomBase:mah] synonym: "increased nuclear bulk poly(A)+ mRNA level during vegetative growth" EXACT [PomBase:vw] synonym: "increased total nuclear polyadenylated messenger RNA level during vegetative growth" EXACT [PomBase:mah] synonym: "increased total nuclear polyadenylated mRNA accumulation during vegetative growth" RELATED [PomBase:mah] synonym: "increased total nuclear polyadenylated mRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased total nuclear polyadenylated mRNA transcript level during vegetative growth" EXACT [PomBase:vw] synonym: "total nuclear poly(A)+ mRNA accumulation" RELATED [PomBase:vw] synonym: "total nuclear poly-A mRNA accumulation" RELATED [PomBase:vw] is_a: FYPO:0003119 ! increased nuclear polyadenylated mRNA level during vegetative growth created_by: midori creation_date: 2014-09-01T16:26:37Z [Term] id: FYPO:0003753 name: increased specific nuclear polyadenylated mRNA level during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more specific polyadenylated messenger RNAs (mRNAs) measured in the nucleus is higher than normal." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased level of specific nuclear polyadenylated mRNA during vegetative growth" EXACT [PomBase:mah] synonym: "increased nuclear specific poly(A)+ mRNA level during vegetative growth" EXACT [PomBase:vw] synonym: "increased specific nuclear polyadenylated messenger RNA level during vegetative growth" EXACT [PomBase:mah] synonym: "increased specific nuclear polyadenylated mRNA accumulation during vegetative growth" RELATED [PomBase:mah] synonym: "increased specific nuclear polyadenylated mRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased specific nuclear polyadenylated mRNA transcript level during vegetative growth" EXACT [PomBase:vw] synonym: "specific nuclear poly(A)+ mRNA accumulation" RELATED [PomBase:vw] synonym: "specific nuclear poly-A mRNA accumulation" RELATED [PomBase:vw] is_a: FYPO:0003119 ! increased nuclear polyadenylated mRNA level during vegetative growth created_by: midori creation_date: 2014-09-01T16:28:38Z [Term] id: FYPO:0003754 name: multiple mitotic spindles def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which a cell contains more than one mitotic spindle." [PomBase:mah] synonym: "additional mitotic spindles present during vegetative growth" EXACT [PomBase:mah] synonym: "extra mitotic spindles during vegetative growth" EXACT [PomBase:mah] synonym: "increased number of mitotic spindles" EXACT [PomBase:vw] synonym: "mitotic spindles present in greater numbers during vegetative growth" EXACT [PomBase:mah] synonym: "multiple spindles during mitosis" RELATED [PomBase:mah] is_a: FYPO:0000338 ! abnormal mitotic spindle is_a: PATO:0002002 ! has extra parts of type intersection_of: PATO:0002002 ! has extra parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0072686 ! mitotic spindle relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0072686 ! mitotic spindle created_by: midori creation_date: 2014-09-01T16:36:05Z [Term] id: FYPO:0003755 name: abnormal vegetative cell phenotype def: "A phenotype that shows detectable differences from normal at the level of an individual cell, when the cell is in the vegetative growth phase of the cell cycle. In fission yeast, the characteristics of wild type cells of the sequenced strain (972 h-) or the isogenic h+ or h90 strains are regarded as normal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "abnormal cell phenotype during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal vegetative fission yeast cell phenotype" EXACT [PomBase:mah] is_a: FYPO:0001320 ! vegetative cell phenotype is_a: FYPO:0003037 ! abnormal cell phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in FYPO:0001320 ! vegetative cell phenotype intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in FYPO:0001320 ! vegetative cell phenotype relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-09-01T17:20:24Z [Term] id: FYPO:0003756 name: multiple mitotic spindles with abolished sister chromatid separation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell has more than one mitotic spindle, and mitotic sister chromatid separation does not occur." [PMID:8978688, PomBase:mah] synonym: "multiple mitotic spindles with abolished chromosome separation" EXACT [PomBase:mah] synonym: "multiple mitotic spindles with abolished sister chromatid segregation" RELATED [PomBase:vw] is_a: FYPO:0003755 ! abnormal vegetative cell phenotype intersection_of: FYPO:0003755 ! abnormal vegetative cell phenotype intersection_of: has_part FYPO:0001946 ! abolished mitotic sister chromatid separation intersection_of: has_part FYPO:0003754 ! multiple mitotic spindles relationship: has_part FYPO:0001946 ! abolished mitotic sister chromatid separation relationship: has_part FYPO:0003754 ! multiple mitotic spindles created_by: midori creation_date: 2014-09-01T17:24:07Z [Term] id: FYPO:0003757 name: incomplete mitotic sister chromatid segregation def: "A cellular process phenotype in which mitotic sister chromatid segregation stops before completing separation of chromosomes; some, but not all, DNA may be moved towards the ends of an elongated mitotic spindle." [PMID:8978688, PomBase:mah, PomBase:vw] synonym: "arrested mitotic sister chromatid segregation" RELATED [PATO:0000297] is_a: FYPO:0000141 ! abnormal mitotic sister chromatid segregation created_by: midori creation_date: 2014-09-01T17:30:48Z [Term] id: FYPO:0003758 name: incomplete mitotic sister chromatid segregation, with unseparated DNA def: "A cellular process phenotype in which mitotic sister chromatid segregation stops before completing separation of chromosomes, and DNA remains in a single mass at or near the midpoint of the mitotic spindle." [PMID:8978688, PomBase:mah] comment: Note that cells with this phenotype often (but not always) proceed to a cut (FYPO:0003165) phenotype. synonym: "archery-bow phenotype" EXACT [PMID:8978688] synonym: "incomplete mitotic sister chromatid segregation, with unseparated DNA during vegetative growth" EXACT [PomBase:mah] synonym: "incomplete mitotic sister chromatid separation, with unseparated DNA" RELATED [PomBase:mah] is_a: FYPO:0003757 ! incomplete mitotic sister chromatid segregation relationship: has_part FYPO:0001946 ! abolished mitotic sister chromatid separation created_by: midori creation_date: 2014-09-01T17:31:22Z [Term] id: FYPO:0003759 name: inviable after spore germination, single or double cell division, arrest with single nucleus def: "A phenotype in which a spore germinates to produce a cell of normal morphology that undergoes one or two rounds of cell division, and all cells produced arrest the cell cycle with a single nucleus and then die." [PomBase:mah, PomBase:vw] synonym: "essential; germinating spore, single or double cell division, arrest with single nucleus" RELATED [PomBase:mah] synonym: "inviable following spore germination, single or double cell division, arrest with single nucleus" EXACT [PomBase:mah] synonym: "inviable germinated spore, single or double cell division, arrest with single nucleus" EXACT [PomBase:mah] is_a: FYPO:0000060 ! mononucleate vegetative cell is_a: FYPO:0001042 ! inviable after spore germination, single or double cell division created_by: midori creation_date: 2014-09-01T19:20:58Z [Term] id: FYPO:0003760 name: inviable after spore germination, single or double cell division, arrest with cut def: "A phenotype in which a spore germinates to produce a cell of normal morphology that undergoes one or two rounds of cell division, and all cells produced arrest the cell cycle with a nucleus that is bisected by a septum, and then die." [PomBase:mah, PomBase:vw] synonym: "essential; germinating spore, single or double cell division, arrest with cut" RELATED [PomBase:mah] synonym: "inviable following spore germination, single or double cell division, arrest with cut" EXACT [PomBase:mah] synonym: "inviable germinated spore, single or double cell division, arrest with cut" EXACT [PomBase:mah] is_a: FYPO:0001055 ! cut following normal mitotic entry is_a: FYPO:0003759 ! inviable after spore germination, single or double cell division, arrest with single nucleus created_by: midori creation_date: 2014-09-01T19:22:23Z [Term] id: FYPO:0003761 name: inviable after spore germination, single or double cell division, arrest with anucleate cell def: "A phenotype in which a spore germinates to produce a cell of normal morphology that undergoes one or two rounds of cell division, and all cells produced arrest the cell cycle with a septum separating a compartment with one nucleus and a second compartment with no nucleus, and then die." [PomBase:mah, PomBase:vw] comment: This term was made obsolete because it was requested in error and does not make sense. synonym: "essential; germinating spore, single or double cell division, arrest with anucleate cell" RELATED [PomBase:mah] synonym: "inviable following spore germination, single or double cell division, arrest with anucleate cell" EXACT [PomBase:mah] synonym: "inviable germinated spore, single or double cell division, arrest with anucleate cell" EXACT [PomBase:mah] is_obsolete: true created_by: midori creation_date: 2014-09-01T19:23:46Z [Term] id: FYPO:0003762 name: normal mitotic cell cycle spindle assembly checkpoint def: "A cell cycle checkpoint phenotype in which the mitotic cell cycle spindle assembly checkpoint is normal (i.e. indistinguishable from wild type). The mitotic spindle assembly checkpoint normally delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [PomBase:mah] synonym: "normal mitotic spindle assembly checkpoint activation" EXACT [PomBase:mah] synonym: "normal spindle assembly checkpoint during mitotic cell cycle" EXACT [PomBase:mah] synonym: "normal spindle assembly checkpoint during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001703 ! normal mitotic cell cycle checkpoint intersection_of: PATO:0000001 ! quality intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0007094 ! mitotic spindle assembly checkpoint intersection_of: qualifier PATO:0000461 ! normal relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0007094 ! mitotic spindle assembly checkpoint relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-09-01T19:26:20Z [Term] id: FYPO:0003763 name: inviable aseptate mononucleate vegetative cell def: "A cell phenotype in which a cell is inviable and contains one nucleus and no septum." [PomBase:mah] synonym: "inviable aseptate mononucleate cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable aseptate mononucleate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable mononucleate aseptate vegetative cell" EXACT [PomBase:mah] synonym: "inviable unseptated mononucleate vegetative cell" EXACT [PomBase:mah] is_a: FYPO:0003785 ! aseptate mononucleate vegetative cell is_a: FYPO:0003931 ! inviable aseptate vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000060 ! mononucleate vegetative cell intersection_of: has_part FYPO:0000949 ! aseptate intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000060 ! mononucleate vegetative cell relationship: has_part FYPO:0000949 ! aseptate relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: output_of FYPO:0001973 ! abnormal cell separation after cytokinesis, with abnormal nuclear division created_by: midori creation_date: 2014-09-08T12:24:07Z [Term] id: FYPO:0003764 name: inviable after spore germination, single or double cell division, arrest with aseptate mononucleate cell def: "A phenotype in which a spore germinates to produce a cell of normal morphology that undergoes one or two rounds of cell division, and all cells produced arrest the cell cycle with one nucleus and no septum, and then die." [PomBase:mah, PomBase:vw] synonym: "essential; germinating spore, single or double cell division, arrest with aseptate mononucleate cell" RELATED [PomBase:mah] synonym: "inviable after spore germination, single or double cell division, arrest with aseptate mononucleate cell" EXACT [PomBase:vw] synonym: "inviable following spore germination, single or double cell division, arrest with aseptate mononucleate cell" EXACT [PomBase:mah] synonym: "inviable germinated spore, single or double cell division, arrest with aseptate mononucleate cell" EXACT [PomBase:mah] is_a: FYPO:0003759 ! inviable after spore germination, single or double cell division, arrest with single nucleus is_a: FYPO:0003763 ! inviable aseptate mononucleate vegetative cell created_by: midori creation_date: 2014-09-08T12:30:32Z [Term] id: FYPO:0003765 name: abolished protein localization to chromatin at centromere central core def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to chromatin at the central core of the centromeric regions is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to chromatin at centromere central core during vegetative growth" EXACT [PomBase:mah] synonym: "abolished protein localization to chromatin at centromere central core during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein localization to chromatin at centromere central core during vegetative growth abolished" EXACT [PomBase:mah] is_a: FYPO:0003744 ! abolished protein localization to centromeric chromatin is_a: FYPO:0003786 ! abolished protein localization to centromere central core intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: occurs_at SO:0001796 ! regional_centromere_central_core intersection_of: towards GO:0071168 ! protein localization to chromatin relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: occurs_at SO:0001796 ! regional_centromere_central_core relationship: towards GO:0071168 ! protein localization to chromatin created_by: midori creation_date: 2014-09-08T12:38:50Z [Term] id: FYPO:0003766 name: aggregated mtDNA def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which mitochondrial DNA molecules are interlinked by unresolved recombination junctions." [PMID:10954073, PomBase:mah] synonym: "aggregated mitochondrial chromosomes" EXACT [PomBase:mah] synonym: "aggregated mitochondrial DNA" EXACT [PomBase:mah] synonym: "fused mitochondrial chromosomes" RELATED [PomBase:mah] synonym: "fused mtDNA" RELATED [PomBase:mah] synonym: "interlinked mtDNA" EXACT [PomBase:mah] is_a: FYPO:0000848 ! abnormal chromosome morphology created_by: midori creation_date: 2014-09-08T15:12:12Z [Term] id: FYPO:0003767 name: decreased crossover junction endodeoxyribonuclease activity def: "A molecular function phenotype in which the observed rate of crossover junction endodeoxyribonuclease activity is decreased." [PomBase:mah] synonym: "reduced crossover junction endodeoxyribonuclease activity" EXACT [PomBase:mah] is_a: FYPO:0002037 ! decreased endodeoxyribonuclease activity is_a: FYPO:0003666 ! abnormal crossover junction endodeoxyribonuclease activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0008821 ! crossover junction endodeoxyribonuclease activity relationship: inheres_in GO:0008821 ! crossover junction endodeoxyribonuclease activity created_by: midori creation_date: 2014-09-08T15:23:36Z [Term] id: FYPO:0003768 name: normal protein localization to mitochondrion def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the mitochondrion is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to mitochondrion" EXACT [PomBase:mah] synonym: "normal protein localization to mitochondria" EXACT [PomBase:mah] synonym: "normal protein localization to mitochondrion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to mitochondrion during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000644 ! normal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0070585 ! protein localization to mitochondrion intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0070585 ! protein localization to mitochondrion relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-09-08T15:25:25Z [Term] id: FYPO:0003769 name: decreased cellular mtDNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of mitochondrial DNA present in the cell is lower than normal." [PomBase:mah] synonym: "decreased mitochondrial DNA content" EXACT [PomBase:mah] synonym: "decreased mitochondrial DNA level" EXACT [PomBase:mah] synonym: "decreased mtDNA level" EXACT [PomBase:mah] synonym: "decreased mtDNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased mtDNA level during vegetative growth" EXACT [PomBase:mah] synonym: "reduced mitochondrial DNA content" EXACT [PomBase:mah] synonym: "reduced mtDNA level" EXACT [PomBase:mah] is_a: FYPO:0000453 ! DNA content decreased during vegetative growth created_by: midori creation_date: 2014-09-08T15:29:40Z [Term] id: FYPO:0003770 name: decreased transcriptional response to pheromone def: "A transcription regulation phenotype in which pheromone-responsive positive regulation of transcription from an RNA polymerase II promoter is decreased." [GO:0007329, PomBase:mah] synonym: "decreased positive regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [GO:0007329] synonym: "reduced positive regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [GO:0007329] is_a: FYPO:0000623 ! abnormal positive regulation of transcription is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0007329 ! positive regulation of transcription from RNA polymerase II promoter by pheromones relationship: inheres_in GO:0007329 ! positive regulation of transcription from RNA polymerase II promoter by pheromones created_by: midori creation_date: 2014-09-08T15:44:26Z [Term] id: FYPO:0003771 name: decreased protein localization to plasma membrane of cell tip def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the plasma membrane surrounding the cell tip is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to plasma membrane of cell tip" EXACT [PomBase:mah] synonym: "decreased protein localization in plasma membrane of cell tip" EXACT [GO:1903418] synonym: "decreased protein localization to plasma membrane of cell tip during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to plasma membrane of cell tip during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to plasma membrane of cell tip" EXACT [PomBase:mah] is_a: FYPO:0001586 ! decreased protein localization to cell tip is_a: FYPO:0002125 ! abnormal protein localization to plasma membrane intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903418 ! protein localization to plasma membrane of cell tip relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903418 ! protein localization to plasma membrane of cell tip created_by: midori creation_date: 2014-09-08T16:10:02Z [Term] id: FYPO:0003772 name: normal transposon gene mRNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of messenger RNA derived from transposon-encoded genes measured in a cell is normal (i.e. indistinguishable from wild type)." [PMID:10022921, PomBase:mah] synonym: "normal level of transposon gene mRNA" EXACT [PomBase:mah] synonym: "normal transposon gene mRNA accumulation" RELATED [PomBase:mah] synonym: "normal transposon gene mRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal transposon gene mRNA level during vegetative growth" EXACT [PomBase:mah] synonym: "normal transposon gene transcript level" EXACT [PomBase:vw] is_a: FYPO:0001317 ! normal RNA level during vegetative growth created_by: midori creation_date: 2014-09-08T16:39:44Z [Term] id: FYPO:0003773 name: normal level of transposon-encoded protein in cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more transposon-encoded proteins measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal level of transposon-encoded protein during vegetative growth" EXACT [PomBase:mah] synonym: "normal level of transposon-encoded protein in cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal transposon-encoded protein accumulation" RELATED [PomBase:mah] synonym: "normal transposon-encoded protein level" EXACT [PomBase:mah] is_a: FYPO:0000833 ! normal protein level during vegetative growth created_by: midori creation_date: 2014-09-08T16:42:46Z [Term] id: FYPO:0003774 name: normal level of transposon-derived cDNA in cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of cDNA derived from transposon-encoded genes measured in a cell is normal (i.e. indistinguishable from wild type)." [PMID:10022921, PomBase:mah] synonym: "normal cellular level of transposon-derived cDNA" EXACT [PomBase:mah] synonym: "normal level of transposon-derived cDNA in cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal level of transposon-derived cDNA in cell during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth created_by: midori creation_date: 2014-09-08T16:47:22Z [Term] id: FYPO:0003775 name: decreased transposon-derived cDNA recombination def: "A cellular process phenotype in which the occurrence of DNA recombination between cDNAs derived from transposon-encoded genes is decreased." [PMID:10022921, PomBase:mah] synonym: "decreased recombination of transposon-derived cDNAs" EXACT [PomBase:mah] synonym: "decreased transposon-derived cDNA recombination frequency" EXACT [PomBase:mah] synonym: "decreased transposon-derived cDNA recombination rate" RELATED [PomBase:mah] synonym: "reduced transposon-derived cDNA recombination" EXACT [PomBase:mah] is_a: FYPO:0002712 ! decreased DNA recombination created_by: midori creation_date: 2014-09-08T16:49:50Z [Term] id: FYPO:0003776 name: increased pseudohyphal growth def: "A cellular process phenotype in which the occurrence of pseudohyphal growth is increased." [PomBase:mah] synonym: "increased filamentous growth" BROAD [PomBase:mah] is_a: FYPO:0000550 ! abnormal pseudohyphal growth is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0007124 ! pseudohyphal growth relationship: inheres_in GO:0007124 ! pseudohyphal growth created_by: midori creation_date: 2014-09-08T16:51:59Z [Term] id: FYPO:0003777 name: abnormal protein localization to endoplasmic reticulum def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the endoplasmic reticulum is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found in the ER and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to endoplasmic reticulum" EXACT [PomBase:mah] synonym: "abnormal protein localization to endoplasmic reticulum during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein localization to endoplasmic reticulum during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal protein localization to ER" EXACT [GO:0005783, PomBase:mah] is_a: FYPO:0000443 ! abnormal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0070972 ! protein localization to endoplasmic reticulum intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0070972 ! protein localization to endoplasmic reticulum relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-09-08T17:10:58Z [Term] id: FYPO:0003778 name: decreased protein localization to endoplasmic reticulum tubular network def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the endoplasmic reticulum tubular network is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to endoplasmic reticulum tubular network" EXACT [PomBase:mah] synonym: "decreased protein localization to endoplasmic reticulum tubular network during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to endoplasmic reticulum tubular network during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein localization to ER tubular network" EXACT [GO:0071782, PomBase:mah] synonym: "decreased protein localization to tubular ER" EXACT [PomBase:al] synonym: "reduced protein localization to endoplasmic reticulum tubular network" EXACT [PomBase:mah] is_a: FYPO:0003777 ! abnormal protein localization to endoplasmic reticulum is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903420 ! protein localization to endoplasmic reticulum tubular network relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903420 ! protein localization to endoplasmic reticulum tubular network created_by: midori creation_date: 2014-09-08T17:13:21Z [Term] id: FYPO:0003779 name: abnormal nuclear envelope morphology during mitosis def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of all or part of the nuclear envelope is abnormal during mitosis." [PomBase:mah] comment: Note that an abnormal nuclear envelope organization process may, but does not necessarily, result in abnormal nuclear envelope morphology. synonym: "abnormal nuclear envelope morphology during mitosis during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal nuclear envelope morphology during mitotic M phase" EXACT [PomBase:mah] synonym: "abnormal nuclear envelope morphology during mitotic nuclear division" EXACT [PomBase:mah] synonym: "abnormal nuclear membrane morphology during mitosis" NARROW [PomBase:mah] is_a: FYPO:0000769 ! abnormal nuclear envelope morphology during vegetative growth intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0007067 ! mitotic nuclear division intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005635 ! nuclear envelope intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0007067 ! mitotic nuclear division relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005635 ! nuclear envelope relationship: output_of FYPO:0000815 ! abnormal nuclear envelope organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-09-08T17:20:22Z [Term] id: FYPO:0003780 name: normal nuclear envelope morphology during mitosis def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of all or part of the nuclear envelope is normal (i.e. indistinguishable from wild type) during mitosis." [PomBase:mah] synonym: "normal nuclear envelope morphology during mitosis during vegetative growth" EXACT [PomBase:mah] synonym: "normal nuclear envelope morphology during mitotic M phase" EXACT [PomBase:mah] synonym: "normal nuclear envelope morphology during mitotic nuclear division" EXACT [PomBase:mah] synonym: "normal nuclear membrane morphology during mitosis" NARROW [PomBase:mah] is_a: FYPO:0003751 ! normal nuclear envelope morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0007067 ! mitotic nuclear division intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005635 ! nuclear envelope intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0007067 ! mitotic nuclear division relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005635 ! nuclear envelope relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-09-08T17:21:52Z [Term] id: FYPO:0003781 name: normal nuclear envelope morphology during mitotic interphase def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of all or part of the nuclear envelope is normal (i.e. indistinguishable from wild type) during interphase of the mitotic cell cycle." [PomBase:mah] synonym: "normal nuclear envelope morphology during interphase during vegetative growth" EXACT [PomBase:mah] synonym: "normal nuclear envelope morphology during mitotic interphase" EXACT [PomBase:mah] synonym: "normal nuclear membrane morphology during mitotic interphase" NARROW [PomBase:mah] is_a: FYPO:0003751 ! normal nuclear envelope morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0051329 ! mitotic interphase intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005635 ! nuclear envelope intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0051329 ! mitotic interphase relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005635 ! nuclear envelope relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-09-08T17:23:16Z [Term] id: FYPO:0003782 name: normal nuclear pore distribution during mitotic interphase def: "A localization phenotype observed in the vegetative growth phase of the life cycle in which the spatial arrangement of nuclear pores within the nuclear envelope is normal (i.e. indistinguishable from wild type) during interphase of the mitotic cell cycle." [PomBase:mah] synonym: "normal nuclear pore distribution during interphase during vegetative growth" EXACT [PomBase:mah] synonym: "normal nuclear pore distribution during interphase of mitotic cell cycle" EXACT [PomBase:mah] is_a: FYPO:0000771 ! normal nuclear pore distribution intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0051329 ! mitotic interphase intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0031081 ! nuclear pore distribution intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0051329 ! mitotic interphase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0031081 ! nuclear pore distribution relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-09-08T17:24:43Z [Term] id: FYPO:0003783 name: abnormal nuclear pore distribution during mitosis def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the spatial arrangement of nuclear pores within the nuclear envelope is abnormal during mitosis." [PomBase:mah] synonym: "abnormal nuclear pore distribution during mitosis during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal nuclear pore distribution during mitotic M phase" EXACT [PomBase:mah] synonym: "abnormal nuclear pore distribution during mitotic nuclear division" EXACT [PomBase:mah] is_a: FYPO:0003973 ! abnormal nuclear pore distribution intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0007067 ! mitotic nuclear division intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0031081 ! nuclear pore distribution intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0007067 ! mitotic nuclear division relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0031081 ! nuclear pore distribution relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-09-08T17:25:07Z [Term] id: FYPO:0003784 name: inviable after spore germination, single or double cell division, arrest with septated mononucleate cell def: "A phenotype in which a spore germinates to produce a cell of normal morphology that undergoes one or two rounds of cell division, and all cells produced arrest the cell cycle with a septum and a nucleus in one compartment, and then die." [PomBase:mah, PomBase:vw] synonym: "essential; germinating spore, single or double cell division, arrest with septated mononucleate cell" RELATED [PomBase:mah] synonym: "inviable after spore germination, single or double cell division, arrest with septated cell and single nucleus" EXACT [PomBase:vw] synonym: "inviable after spore germination, single or double cell division, arrest with septated mononucleate cell" EXACT [PomBase:vw] synonym: "inviable following spore germination, single or double cell division, arrest with septated mononucleate cell" EXACT [PomBase:mah] synonym: "inviable germinated spore, single or double cell division, arrest with septated mononucleate cell" EXACT [PomBase:mah] is_a: FYPO:0002000 ! inviable septated mononucleate vegetative cell is_a: FYPO:0003759 ! inviable after spore germination, single or double cell division, arrest with single nucleus created_by: midori creation_date: 2014-09-09T11:07:33Z [Term] id: FYPO:0003785 name: aseptate mononucleate vegetative cell def: "A cell phenotype in which a cell contains one nucleus and no septum." [PomBase:mah] synonym: "aseptate mononucleate cell during vegetative growth" EXACT [PomBase:mah] synonym: "aseptate mononucleate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "mononucleate aseptate vegetative cell" EXACT [PomBase:mah] synonym: "unseptated mononucleate vegetative cell" EXACT [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000060 ! mononucleate vegetative cell intersection_of: has_part FYPO:0000949 ! aseptate relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000060 ! mononucleate vegetative cell relationship: has_part FYPO:0000949 ! aseptate created_by: midori creation_date: 2014-09-09T11:19:49Z [Term] id: FYPO:0003786 name: abolished protein localization to centromere central core def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the central core of the centromeric regions is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to centromere central core during vegetative growth" EXACT [PomBase:mah] synonym: "abolished protein localization to centromere central core during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein localization to centromere central core during vegetative growth abolished" EXACT [PomBase:mah] is_a: FYPO:0000634 ! abolished protein localization to centromere intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: occurs_at SO:0001796 ! regional_centromere_central_core intersection_of: towards GO:0071459 ! protein localization to chromosome, centromeric region relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: occurs_at SO:0001796 ! regional_centromere_central_core relationship: towards GO:0071459 ! protein localization to chromosome, centromeric region created_by: midori creation_date: 2014-09-09T13:24:06Z [Term] id: FYPO:0003787 name: long mitotic spindle microtubules protruding beyond spindle pole body def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells form mitotic spindle microtubules that are longer than normal, and extend beyond the spindle pole body. The protruding spindle microtubules are surrounded by an extension of the nuclear envelope." [PMID:17486116, PomBase:mah] synonym: "elongated mitotic spindle microtubules protruding from spindle pole body" EXACT [PomBase:mah] synonym: "elongated mitotic spindle microtubules protruding from spindle pole body during M-phase" EXACT [PomBase:vw] synonym: "long mitotic spindle microtubules protruding beyond spindle pole body, with nuclear envelope protrusion" EXACT [PomBase:vw] synonym: "long mitotic spindle microtubules protruding from SPB" EXACT [PomBase:mah] synonym: "long mitotic spindle microtubules protruding from spindle pole body during mitotic cell cycle" RELATED [PomBase:mah] synonym: "long mitotic spindle microtubules protruding from spindle pole body during vegetative growth" EXACT [PomBase:mah] synonym: "nuclear envelope protrusion with long mitotic spindle microtubules protruding beyond spindle pole body" EXACT [PomBase:vw] is_a: FYPO:0000055 ! long microtubules is_a: FYPO:0000733 ! long mitotic spindle relationship: has_part FYPO:0003788 ! nuclear envelope protrusion present during mitosis created_by: midori creation_date: 2014-09-09T13:26:10Z [Term] id: FYPO:0003788 name: nuclear envelope protrusion present during mitosis def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the nuclear envelope has one or more extensions that protrude into the cytoplasm during mitosis." [PMID:17486116, PMID:25103238, PomBase:mah] comment: This term differs from 'lobate nuclear envelope' (FYPO:0002005) in that a lobate envelope has a few deep fissures extending inward from the cytoplasm that appear to partially divide the nucleus into portions, whereas protrusions are smaller and extend outward from the bulk of the nucleus. synonym: "nuclear envelope protrusion present during mitotic cell cycle" RELATED [PomBase:mah] synonym: "nuclear envelope protrusion present during mitotic M phase" EXACT [PomBase:mah] synonym: "nuclear envelope protrusion present during mitotic nuclear division" EXACT [GO:0007067] synonym: "nuclear envelope protrusion present during vegetative growth" EXACT [PomBase:mah] synonym: "protruding nuclear envelope during mitosis" EXACT [PomBase:mah] is_a: FYPO:0003779 ! abnormal nuclear envelope morphology during mitosis is_a: PATO:0001598 ! protruding intersection_of: PATO:0001598 ! protruding intersection_of: exists_during GO:0007067 ! mitotic nuclear division intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005635 ! nuclear envelope relationship: exists_during GO:0007067 ! mitotic nuclear division relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005635 ! nuclear envelope created_by: midori creation_date: 2014-09-09T13:34:47Z [Term] id: FYPO:0003789 name: decreased meiosis II def: "A cellular process phenotype in which the occurrence of the second meiotic nuclear division, in which two chromatids in each chromosome are normally separated, is decreased." [PomBase:mah] synonym: "decreased second meiotic nuclear division" EXACT [PomBase:al] synonym: "meiosis II: decreased" EXACT [PomBase:mah] synonym: "reduced meiosis II" EXACT [PomBase:mah] is_a: FYPO:0000476 ! decreased meiosis intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0007135 ! meiosis II relationship: inheres_in GO:0007135 ! meiosis II created_by: midori creation_date: 2014-09-09T14:01:31Z [Term] id: FYPO:0003790 name: normal protein localization during meiosis def: "A cell phenotype in which the localization of a protein in a cell is normal (i.e. indistinguishable from wild type) during the first or second meiotic nuclear division." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation during meiosis" EXACT [PomBase:mah] synonym: "normal protein localization during meiotic nuclear division" EXACT [PomBase:mah] is_a: FYPO:0004095 ! normal protein localization during meiotic cell cycle intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0007126 ! meiotic nuclear division intersection_of: inheres_in GO:0034613 ! cellular protein localization intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0007126 ! meiotic nuclear division relationship: inheres_in GO:0034613 ! cellular protein localization relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-09-09T14:03:28Z [Term] id: FYPO:0003791 name: increased meiotic recombination at silent mating-type cassette def: "A cellular process phenotype in which the occurrence of reciprocal meiotic recombination is increased at the silent mating-type cassettes." [PomBase:mah] is_a: FYPO:0000487 ! increased meiotic recombination is_a: FYPO:0003346 ! abnormal meiotic recombination at silent mating-type cassette intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0007131 ! reciprocal meiotic recombination intersection_of: occurs_at SO:0001984 ! silent_mating_type_cassette_array relationship: inheres_in GO:0007131 ! reciprocal meiotic recombination relationship: occurs_at SO:0001984 ! silent_mating_type_cassette_array created_by: midori creation_date: 2014-09-09T14:37:37Z [Term] id: FYPO:0003792 name: increased meiotic DNA double-strand break formation at silent mating-type cassette def: "A cellular process phenotype in which generation of double-strand breaks at defined hotspots throughout the genome during meiosis I is increased at the silent mating-type cassettes." [PomBase:mah] is_a: FYPO:0003346 ! abnormal meiotic recombination at silent mating-type cassette is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0042138 ! meiotic DNA double-strand break formation intersection_of: occurs_at SO:0001984 ! silent_mating_type_cassette_array relationship: inheres_in GO:0042138 ! meiotic DNA double-strand break formation relationship: occurs_at SO:0001984 ! silent_mating_type_cassette_array created_by: midori creation_date: 2014-09-09T14:41:21Z [Term] id: FYPO:0003793 name: normal RNA level during cellular response to osmotic stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to osmotic stress is normal (i.e. indistinguishable from wild type). Total RNA or a specific RNA may be affected." [PomBase:mah] comment: We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "normal mRNA level during cellular response to osmotic stress" NARROW [PomBase:mah] synonym: "normal RNA accumulation during cellular response to osmotic stress" RELATED [PomBase:mah] synonym: "normal RNA level during cellular response to osmotic stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal RNA level during cellular response to osmotic stress during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001317 ! normal RNA level during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0071470 ! cellular response to osmotic stress intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0071470 ! cellular response to osmotic stress relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-09-09T14:57:46Z [Term] id: FYPO:0003794 name: normal cellular glycerol level during cellular response to osmotic stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of glycerol measured in a cell is normal (i.e. indistinguishable from wild type) during a cellular response to osmotic stress." [PomBase:mah] synonym: "normal cellular glycerol accumulation during cellular response to osmotic stress" RELATED [PomBase:mah] synonym: "normal cellular glycerol level during cellular response to osmotic stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular glycerol level during cellular response to osmotic stress during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0071470 ! cellular response to osmotic stress intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:17754 ! glycerol relationship: exists_during GO:0071470 ! cellular response to osmotic stress relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:17754 ! glycerol created_by: midori creation_date: 2014-09-09T15:00:03Z [Term] id: FYPO:0003795 name: normal cell wall alpha-glucan level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of alpha-D-glucan measured in the cell wall is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cell wall alpha-D-glucan level" EXACT [CHEBI:22385, PomBase:mah] synonym: "normal cell wall alpha-glucan accumulation" RELATED [PomBase:mah] synonym: "normal cell wall alpha-glucan level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cell wall alpha-glucan level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001196 ! normal alpha-glucan level is_a: FYPO:0001313 ! normal subcellular component during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0009277 ! fungal-type cell wall intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:22385 ! alpha-D-glucan relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0009277 ! fungal-type cell wall relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:22385 ! alpha-D-glucan created_by: midori creation_date: 2014-09-09T15:07:56Z [Term] id: FYPO:0003796 name: abolished transcription from RNA polymerase II promoter def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription from an RNA polymerase II promoter does not occur. All genes, or a specific subset of genes, may be affected." [PMID:16874521, PomBase:mah] synonym: "abolished transcription from RNA polymerase II promoter during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished transcription from RNA polymerase II promoter during vegetative growth" EXACT [PomBase:mah] synonym: "transcription from RNA polymerase II promoter abolished" EXACT [PomBase:mah] is_a: FYPO:0001443 ! abolished transcription during vegetative growth intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0006366 ! transcription from RNA polymerase II promoter relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0006366 ! transcription from RNA polymerase II promoter created_by: midori creation_date: 2014-09-09T15:27:35Z [Term] id: FYPO:0003797 name: normal conjugation frequency def: "A conjugation phenotype in which conjugation occurs at a normal (i.e. indistinguishable from wild type) frequency." [PomBase:mah] comment: Note that this term refers specifically to conjugation, whereas experiments that measure mating efficiency often do so by counting zygotes plus asci, sometimes also including spores. For such experiments, we recommend using 'normal mating efficiency' (FYPO:0001147). synonym: "normal conjugation efficiency" EXACT [PomBase:mah] synonym: "normal occurrence of conjugation" EXACT [PomBase:mah] synonym: "normal zygote formation" RELATED [PomBase:mah] is_a: FYPO:0000760 ! normal conjugation is_a: PATO:0000044 ! frequency intersection_of: PATO:0000044 ! frequency intersection_of: inheres_in GO:0000747 ! conjugation with cellular fusion intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0000747 ! conjugation with cellular fusion relationship: part_of FYPO:0000760 ! normal conjugation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-09-09T15:33:50Z [Term] id: FYPO:0003798 name: normal meiosis II def: "A cellular process phenotype in which the second meiotic nuclear division is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal second meiotic nuclear division" EXACT [PomBase:mah] is_a: FYPO:0000478 ! normal meiosis intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0007135 ! meiosis II intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0007135 ! meiosis II relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-09-09T15:36:52Z [Term] id: FYPO:0003799 name: normal chromatin binding during recovery from nitrogen starvation def: "A molecular function phenotype in which occurrence of chromatin binding by a gene product (usually a protein) in a mutant is normal (i.e. indistinguishable from wild type) in cells that are returned to nitrogen-rich medium following nitrogen starvation." [PomBase:mah] synonym: "normal chromatin binding during recovery from nitrogen depletion" EXACT [PomBase:mah] synonym: "normal chromatin binding during recovery from nitrogen deprivation" RELATED [PomBase:mah] is_a: FYPO:0003086 ! normal chromatin binding created_by: midori creation_date: 2014-09-12T13:19:06Z [Term] id: FYPO:0003800 name: normal chromatin binding at replication origin def: "A molecular function phenotype in which occurrence of chromatin binding by a gene product (usually a protein) in a mutant is normal (i.e. indistinguishable from wild type) at an origin of replication." [PomBase:mah] synonym: "normal chromatin binding at origin of replication" EXACT [PomBase:mah] is_a: FYPO:0003086 ! normal chromatin binding intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0003682 ! chromatin binding intersection_of: occurs_at SO:0000296 ! origin_of_replication intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0003682 ! chromatin binding relationship: occurs_at SO:0000296 ! origin_of_replication relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-09-12T13:30:03Z [Term] id: FYPO:0003801 name: decreased chromatin binding at replication origin def: "A molecular function phenotype in which occurrence of chromatin binding by a gene product (usually a protein) at an origin of replication." [PomBase:mah] synonym: "decreased chromatin binding at origin of replication" EXACT [PomBase:mah] synonym: "reduced chromatin binding at replication origin" EXACT [PomBase:mah] is_a: FYPO:0002577 ! decreased chromatin binding intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0003682 ! chromatin binding intersection_of: occurs_at SO:0000296 ! origin_of_replication relationship: inheres_in GO:0003682 ! chromatin binding relationship: occurs_at SO:0000296 ! origin_of_replication created_by: midori creation_date: 2014-09-12T13:32:07Z [Term] id: FYPO:0003802 name: increased histone H3-K14 acetylation at telomere def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which acetylation of lysine at position 14 of histone H3 in telomeric regions occurs to a greater extent than normal." [PomBase:mah] synonym: "increased histone H3-K14 acetylation at telomere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H3-K14 acetylation at telomere during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000788 ! abnormal histone H3-K14 acetylation is_a: FYPO:0002363 ! increased histone H3 acetylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0044154 ! histone H3-K14 acetylation intersection_of: occurs_at SO:0000624 ! telomere relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0044154 ! histone H3-K14 acetylation relationship: occurs_at SO:0000624 ! telomere created_by: midori creation_date: 2014-09-12T13:39:30Z [Term] id: FYPO:0003803 name: decreased protein localization to telomere def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the telomere of a chromosome is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to telomere" EXACT [PomBase:mah] synonym: "decreased protein localization to chromosome, telomeric region" EXACT [GO:0070198, PomBase:mah] synonym: "decreased protein localization to telomere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to telomere during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein localization to telomeric region" EXACT [PomBase:vw] synonym: "reduced protein localization to telomere" EXACT [PomBase:mah] is_a: FYPO:0002839 ! decreased protein localization to chromosome intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0070198 ! protein localization to chromosome, telomeric region relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0070198 ! protein localization to chromosome, telomeric region created_by: midori creation_date: 2014-09-12T13:45:25Z [Term] id: FYPO:0003804 name: normal growth on non-fermentable carbon source def: "A vegetative cell population growth phenotype in which cells grow normally in a medium containing one or more non-fermentable substance(s) as the only carbon source(s)." [PomBase:mah] comment: Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. Also consider annotating to one or more terms that describe growth on a specific carbon source. synonym: "normal cell population growth on non-fermentable carbon source" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal vegetative cell population growth on non-fermentable carbon source" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth created_by: midori creation_date: 2014-09-12T13:59:04Z [Term] id: FYPO:0003805 name: decreased cell population growth on non-fermentable carbon source def: "A vegetative cell population growth phenotype in which cell growth is decreased relative to normal in a medium containing one or more non-fermentable substance(s) as the only carbon source(s)." [PomBase:mah] comment: Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. Also consider annotating to one or more terms that describe growth on a specific carbon source. synonym: "decreased growth on non-fermentable carbon source" BROAD [PomBase:mah] synonym: "decreased vegetative cell growth on non-fermentable carbon source" EXACT [PomBase:mah] synonym: "reduced cell growth on non-fermentable carbon source" EXACT [PomBase:mah] synonym: "slow cell growth on gluconate carbon source" NARROW [PomBase:mah] is_a: FYPO:0001355 ! decreased vegetative cell population growth created_by: midori creation_date: 2014-09-12T14:05:29Z [Term] id: FYPO:0003806 name: abolished cell population growth on non-fermentable carbon source def: "A vegetative cell population growth phenotype in which a cell population does not grow in a medium containing one or more non-fermentable substance(s) as the only carbon source(s)." [PomBase:mah] comment: Use this term for a population of cells that does not grow with a non-fermentable carbon source, but does grow using a different carbon source (a cell population that does not grow on any media would be considered inviable). Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. Also consider annotating to one or more terms that describe growth on a specific carbon source. synonym: "abolished growth on non-fermentable carbon source" BROAD [PomBase:mah] synonym: "abolished non-fermentable carbon source utilization" RELATED [PomBase:mah, PomBase:vw] synonym: "abolished vegetative cell population growth on non-fermentable carbon source" EXACT [PomBase:mah] synonym: "cell population growth on non-fermentable carbon source abolished" EXACT [PomBase:mah] is_a: FYPO:0001575 ! abolished vegetative cell population growth is_a: FYPO:0003805 ! decreased cell population growth on non-fermentable carbon source created_by: midori creation_date: 2014-09-12T14:06:27Z [Term] id: FYPO:0003807 name: branched mitochondria def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which mitochondria form branched structures." [PMID:19373772, PomBase:mah] synonym: "branched mitochondria during mitotic cell cycle" RELATED [PomBase:mah] synonym: "branched mitochondria during vegetative growth" EXACT [PomBase:mah] synonym: "branched mitochondrion" EXACT [PomBase:mah] is_a: FYPO:0000359 ! abnormal mitochondrial morphology is_a: PATO:0000402 ! branched intersection_of: PATO:0000402 ! branched intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005739 ! mitochondrion relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005739 ! mitochondrion created_by: midori creation_date: 2014-09-12T14:36:24Z [Term] id: FYPO:0003808 name: normal mitochondrial motility def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the movement of mitochondria is normal (i.e. indistinguishable from wild type). Mitochondria normally form tips that grow and shrink stochastically." [PMID:19373772, PomBase:mah] synonym: "normal mitochondrial dynamics" EXACT [PMID:19373772, PomBase:mah] synonym: "normal mitochondrial mobility" EXACT [PATO:0000004, PomBase:mah] synonym: "normal mitochondrial motility during mitotic cell cycle" EXACT [PomBase:mah] synonym: "normal mitochondrial motility during vegetative growth" EXACT [PomBase:mah] synonym: "normal nuclear membrane morphology" NARROW [PomBase:mah] is_a: FYPO:0001313 ! normal subcellular component during vegetative growth is_a: PATO:0000004 ! mobility intersection_of: PATO:0000004 ! mobility intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005739 ! mitochondrion intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005739 ! mitochondrion relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-09-12T14:47:56Z [Term] id: FYPO:0003809 name: normal growth on latrunculin A def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing latrunculin A." [PomBase:mah] synonym: "normal cell population growth in presence of latrunculin A" EXACT [PomBase:mah] synonym: "normal cell population growth on latrunculin A" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to latrunculin A" RELATED [PomBase:al, PomBase:mah] synonym: "normal growth on LAT-A" EXACT [PomBase:vw] synonym: "normal vegetative cell population growth on latrunculin A" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:69136 ! latrunculin A relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:69136 ! latrunculin A created_by: midori creation_date: 2014-09-12T14:52:10Z [Term] id: FYPO:0003810 name: fragmented mitochondria def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which mitochondria are broken into multiple small fragments that are smaller than a normal mitochondrion." [PomBase:mah] synonym: "fragmented mitochondria during mitotic cell cycle" RELATED [PomBase:mah] synonym: "fragmented mitochondria during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000359 ! abnormal mitochondrial morphology is_a: PATO:0001444 ! broken intersection_of: PATO:0001444 ! broken intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005739 ! mitochondrion relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005739 ! mitochondrion created_by: midori creation_date: 2014-09-12T14:56:05Z [Term] id: FYPO:0003811 name: monopolar intracellular mitochondrion distribution def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitochondria are localized to only one end of a cell." [PomBase:mah] synonym: "mitochondria localized to one cell end" EXACT [PomBase:vw] synonym: "monopolar intracellular mitochondrion distribution during mitotic cell cycle" RELATED [PomBase:mah] synonym: "monopolar intracellular mitochondrion distribution during vegetative growth" EXACT [PomBase:mah] synonym: "monopolar intracellular mitochondrion localisation" EXACT [PomBase:mah] synonym: "monopolar intracellular mitochondrion localization" EXACT [PomBase:mah] synonym: "monopolar mitochondrion distribution" EXACT [PomBase:mah] is_a: FYPO:0000894 ! abnormal intracellular mitochondrion distribution created_by: midori creation_date: 2014-09-12T14:59:40Z [Term] id: FYPO:0003812 name: abnormal nucleosome positioning at stress response genes def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which nucleosome positioning is abnormal near the promoter regions of genes that are expressed in response to stress. Nucleosome positioning is the ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another." [GO:0016584, PomBase:mah] synonym: "abnormal nucleosome positioning at stress response genes during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal nucleosome positioning at stress response genes during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal nucleosome spacing at stress response genes" EXACT [GO:0016584, PomBase:mah] is_a: FYPO:0000854 ! abnormal nucleosome positioning in euchromatin created_by: midori creation_date: 2014-09-12T15:35:00Z [Term] id: FYPO:0003813 name: normal nucleosome positioning at stress response genes def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which nucleosome positioning is normal (i.e. indistinguishable from wild type) near the promoter regions of genes that are expressed in response to stress. Nucleosome positioning is the ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another." [GO:0016584, PomBase:mah] synonym: "normal nucleosome positioning at stress response genes during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal nucleosome positioning at stress response genes during vegetative growth" EXACT [PomBase:mah] synonym: "normal nucleosome spacing at stress response genes" EXACT [GO:0016584, PomBase:mah] is_a: FYPO:0000857 ! normal nucleosome positioning in euchromatin created_by: midori creation_date: 2014-09-12T15:36:34Z [Term] id: FYPO:0003814 name: abolished response to S-phase DNA damage checkpoint signaling def: "A cellular process phenotype in which a mitotic cell cycle arrest that normally occurs in response to the S phase DNA damage checkpoint (also known as the intra-S phase DNA damage checkpoint) does not occur. The S phase DNA damage checkpoint slows progression through S phase in response to DNA damage. In a mutant, the checkpoint may fail to arrest or delay cell cycle progression under appropriate conditions, or the incidence or duration of arrest or delay may differ from wild type under any specified set of conditions." [GO:0072429, PomBase:mah] synonym: "abolished response to intra-S DNA damage checkpoint signaling" EXACT [GO:0072429, PomBase:mah] synonym: "abolished response to S-phase DNA damage checkpoint signaling abolished" EXACT [PomBase:mah] synonym: "abolished response to S-phase DNA damage checkpoint signaling during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished response to S-phase DNA damage checkpoint signaling during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000007 ! abnormal S-phase DNA damage checkpoint is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0072429 ! response to intra-S DNA damage checkpoint signaling relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_output FYPO:0004241 ! decreased rate of DNA replication during cellular response to DNA damage relationship: towards GO:0072429 ! response to intra-S DNA damage checkpoint signaling created_by: midori creation_date: 2014-09-12T15:40:24Z [Term] id: FYPO:0003815 name: decreased response to S-phase DNA damage checkpoint signaling def: "A cellular process phenotype in which a mitotic cell cycle arrest that normally occurs in response to the S phase DNA damage checkpoint (also known as the intra-S phase DNA damage checkpoint) is decreased. The S phase DNA damage checkpoint slows progression through S phase in response to DNA damage. In a mutant, the checkpoint may fail to arrest or delay cell cycle progression under appropriate conditions, or the incidence or duration of arrest or delay may differ from wild type under any specified set of conditions." [GO:0072429, PomBase:mah] synonym: "decreased response to intra-S DNA damage checkpoint signaling" EXACT [PomBase:mah] synonym: "decreased S-phase DNA damage checkpoint during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased S-phase DNA damage checkpoint during vegetative growth" EXACT [PomBase:mah] synonym: "reduced response to intra-S DNA damage checkpoint signaling" EXACT [GO:0072429, PomBase:mah] is_a: FYPO:0000007 ! abnormal S-phase DNA damage checkpoint is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072429 ! response to intra-S DNA damage checkpoint signaling relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072429 ! response to intra-S DNA damage checkpoint signaling created_by: midori creation_date: 2014-09-12T15:49:47Z [Term] id: FYPO:0003816 name: growth auxotrophic for histidine or lysine def: "Auxotrophy in which a cell requires histidine or lysine in the medium for vegetative cell growth." [PomBase:mah] synonym: "growth auxotrophic for histidine or lysine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "growth auxotrophic for histidine or lysine during vegetative growth" EXACT [PomBase:mah] synonym: "growth auxotrophic for lysine or histidine" EXACT [PomBase:mah] synonym: "histidine or lysine auxotrophy" EXACT [PomBase:mah] is_a: FYPO:0000128 ! auxotrophy created_by: midori creation_date: 2014-09-12T15:55:36Z [Term] id: FYPO:0003817 name: abnormal ATP-dependent 5'-3' DNA helicase activity def: "A molecular function phenotype in which the observed rate of ATP-dependent 5'-3' DNA helicase activity is abnormal." [PomBase:mah] is_a: FYPO:0001167 ! abnormal ATPase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0043141 ! ATP-dependent 5'-3' DNA helicase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0043141 ! ATP-dependent 5'-3' DNA helicase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-09-12T16:00:55Z [Term] id: FYPO:0003818 name: abolished ATP-dependent 5'-3' DNA helicase activity def: "A molecular function phenotype in which ATP-dependent 5'-3' DNA helicase activity is absent." [PomBase:mah] synonym: "ATP-dependent 5'-3' DNA helicase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0003674 ! abolished ATPase activity is_a: FYPO:0003817 ! abnormal ATP-dependent 5'-3' DNA helicase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0043141 ! ATP-dependent 5'-3' DNA helicase activity relationship: towards GO:0043141 ! ATP-dependent 5'-3' DNA helicase activity created_by: midori creation_date: 2014-09-12T16:01:01Z [Term] id: FYPO:0003819 name: decreased ATP-dependent 5'-3' DNA helicase activity def: "A molecular function phenotype in which the observed rate of ATP-dependent 5'-3' DNA helicase activity is decreased." [PomBase:mah] synonym: "reduced ATP-dependent 5'-3' DNA helicase activity" EXACT [PomBase:mah] is_a: FYPO:0001168 ! decreased ATPase activity is_a: FYPO:0003817 ! abnormal ATP-dependent 5'-3' DNA helicase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0043141 ! ATP-dependent 5'-3' DNA helicase activity relationship: inheres_in GO:0043141 ! ATP-dependent 5'-3' DNA helicase activity created_by: midori creation_date: 2014-09-12T16:01:15Z [Term] id: FYPO:0003820 name: mitochondria present in decreased numbers during vegetative growth def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which a cell contains fewer mitochondria than normal." [PomBase:mah] synonym: "decreased number of mitochondria during vegetative growth" EXACT [PomBase:mah] synonym: "fewer mitochondria during vegetative growth" EXACT [PomBase:mah] synonym: "mitochondria present in decreased numbers during mitotic cell cycle" RELATED [PomBase:mah] synonym: "mitochondria present in reduced numbers during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: PATO:0002001 ! has fewer parts of type intersection_of: PATO:0002001 ! has fewer parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0005739 ! mitochondrion relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0005739 ! mitochondrion created_by: midori creation_date: 2014-09-12T16:10:08Z [Term] id: FYPO:0003821 name: abnormal ribonuclease activity def: "A molecular function phenotype in which the observed rate of a ribonuclease activity is abnormal." [PomBase:mah] is_a: FYPO:0003163 ! abnormal nuclease activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004540 ! ribonuclease activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004540 ! ribonuclease activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-09-12T16:15:37Z [Term] id: FYPO:0003822 name: decreased ribonuclease activity def: "A molecular function phenotype in which the observed rate of a ribonuclease activity is decreased." [PomBase:mah] synonym: "reduced ribonuclease activity" EXACT [PomBase:mah] is_a: FYPO:0003821 ! abnormal ribonuclease activity is_a: FYPO:0004253 ! decreased nuclease activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004540 ! ribonuclease activity relationship: inheres_in GO:0004540 ! ribonuclease activity created_by: midori creation_date: 2014-09-12T16:15:49Z [Term] id: FYPO:0003823 name: septation following abnormal chromosome segregation, with binucleate cell formation during cellular response to hydroxyurea def: "An inviable phenotype observed in the vegetative growth phase of the life cycle in which a cell undergoes septation despite abnormal chromosome segregation, producing inviable daughter cells, and in which the septum forms in a position that partitions both nuclei into one daughter cell, when a cell is exposed to hydroxyurea." [PomBase:mah, PomBase:vw] is_a: FYPO:0003166 ! septation following abnormal chromosome segregation, with anucleate cell formation created_by: midori creation_date: 2014-09-15T17:42:18Z [Term] id: FYPO:0003824 name: resistance to caffeine and rapamycin def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of higher concentrations of caffeine and rapamycin than normal." [PomBase:mah] synonym: "resistance to caffeine and rapamycin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to caffeine and rapamycin during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to caffeine and rapamycin" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth created_by: midori creation_date: 2014-09-18T16:15:41Z [Term] id: FYPO:0003825 name: inviable binucleate aseptate cell with mitotic cell cycle arrest in G2 before cell separation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell is inviable and has two nuclei but no septum, and the mitotic cell cycle is arrested with nuclei in G2 phase." [PomBase:mah] comment: This phenotype may indicate that the cytokinesis after mitosis checkpoint is activated. synonym: "inviable binucleate aseptate cell with mitotic cell cycle arrest in G2 before cytokinesis" EXACT [PomBase:mah] synonym: "inviable binucleate aseptate cell with mitotic cell cycle arrest in G2 phase before cell separation during vegetative growth" EXACT [PomBase:mah] synonym: "inviable binucleate cell with mitotic cell cycle arrest before septation" EXACT [PomBase:mah] synonym: "inviable binucleate cell with mitotic cell cycle arrest in G2 before barrier septum assembly" EXACT [GO:0000917] synonym: "inviable cell with mitotic G2 arrest after failed cytokinesis" RELATED [PomBase:vw] synonym: "inviable cell with nuclear division arrest in G2 without septation (normal cell length)" EXACT [PomBase:vw] synonym: "mitotic cell cycle arrest in G2 before cell separation with inviable binucleate aseptate cell" EXACT [PomBase:vw] is_a: FYPO:0004106 ! inviable multinucleate aseptate vegetative cell is_a: FYPO:0004562 ! binucleate aseptate vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000949 ! aseptate intersection_of: has_part FYPO:0001222 ! binucleate vegetative cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0002888 ! mitotic cell cycle arrest before cell separation intersection_of: has_part FYPO:0003373 ! abnormal cell cycle arrest in mitotic G2 phase relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000949 ! aseptate relationship: has_part FYPO:0001222 ! binucleate vegetative cell relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0002888 ! mitotic cell cycle arrest before cell separation relationship: has_part FYPO:0003373 ! abnormal cell cycle arrest in mitotic G2 phase created_by: midori creation_date: 2014-10-14T15:42:02Z [Term] id: FYPO:0003826 name: inviable elongated binucleate aseptate cell with mitotic cell cycle arrest in G2 before cell separation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell is inviable, is longer than normal, has two nuclei but no septum, and the mitotic cell cycle is arrested with nuclei in G2 phase." [PomBase:mah] comment: This phenotype may indicate that the cytokinesis after mitosis checkpoint is activated. synonym: "inviable cell with nuclear division arrest in G2 without septation (elongated cell)" EXACT [PomBase:vw] synonym: "inviable elongated binucleate aseptate cell with mitotic cell cycle arrest in G2 before cytokinesis" EXACT [PomBase:mah] synonym: "inviable elongated binucleate aseptate cell with mitotic cell cycle arrest in G2 phase before cell separation during vegetative growth" EXACT [PomBase:mah] synonym: "inviable elongated binucleate cell with mitotic cell cycle arrest before septation" EXACT [PomBase:mah] synonym: "inviable elongated binucleate cell with mitotic cell cycle arrest in G2 before barrier septum assembly" EXACT [GO:0000917] synonym: "mitotic cell cycle arrest in G2 before cell separation with inviable elongated binucleate aseptate cell" EXACT [PomBase:vw] synonym: "mitotic G2 arrest after failed cytokinesis, with inviable elongated cell" RELATED [PomBase:vw] is_a: FYPO:0001497 ! inviable elongated vegetative cell with mitotic cell cycle arrest in interphase is_a: FYPO:0003825 ! inviable binucleate aseptate cell with mitotic cell cycle arrest in G2 before cell separation is_a: FYPO:0004684 ! inviable elongated binucleate aseptate cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000949 ! aseptate intersection_of: has_part FYPO:0001122 ! elongated vegetative cell intersection_of: has_part FYPO:0001222 ! binucleate vegetative cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0002888 ! mitotic cell cycle arrest before cell separation intersection_of: has_part FYPO:0003373 ! abnormal cell cycle arrest in mitotic G2 phase relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000949 ! aseptate relationship: has_part FYPO:0001122 ! elongated vegetative cell relationship: has_part FYPO:0001222 ! binucleate vegetative cell relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0002888 ! mitotic cell cycle arrest before cell separation relationship: has_part FYPO:0003373 ! abnormal cell cycle arrest in mitotic G2 phase created_by: midori creation_date: 2014-10-14T15:54:06Z [Term] id: FYPO:0003827 name: decreased ribosomal S6 protein phosphorylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of the ribosomal small subunit protein S6 is decreased." [PMID:24463365, PomBase:mah] synonym: "decreased ribosome S6 phosphorylation" EXACT [PomBase:al] synonym: "reduced ribosomal S6 protein phosphorylation" EXACT [PomBase:mah] is_a: FYPO:0001838 ! decreased protein phosphorylation during vegetative growth created_by: midori creation_date: 2014-10-14T16:07:34Z [Term] id: FYPO:0003828 name: normal ribosomal S6 protein phosphorylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of the ribosomal small subunit protein S6 is normal (i.e. indistinguishable from wild type)." [PMID:24463365, PomBase:mah] synonym: "normal ribosome S6 phosphorylation" EXACT [PomBase:al] is_a: FYPO:0000776 ! normal protein phosphorylation during vegetative growth created_by: midori creation_date: 2014-10-14T16:09:42Z [Term] id: FYPO:0003829 name: abolished mitotic spindle elongation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitotic spindle elongation does not occur." [PomBase:mah] synonym: "abolished spindle elongation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "mitotic spindle elongation abolished" EXACT [PomBase:mah] synonym: "mitotic spindle elongation abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000131 ! abnormal mitotic spindle elongation is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0000022 ! mitotic spindle elongation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0000022 ! mitotic spindle elongation created_by: midori creation_date: 2014-10-14T16:26:09Z [Term] id: FYPO:0003830 name: abnormal cytokinesis checkpoint def: "A cell cycle checkpoint phenotype in which the cytokinesis after mitosis checkpoint of a mitotic cell cycle is abnormal. The cytokinesis after mitosis checkpoint normally delays the G2/M transition of a mitotic cell cycle if cytokinesis was not completed correctly in the previous cell cycle. In a mutant, the checkpoint may fail to arrest or delay cell cycle progression under appropriate conditions, or the incidence or duration of arrest or delay may differ from wild type under any specified set of conditions." [GO:0044878, PomBase:mah] synonym: "abnormal cytokinesis after mitosis checkpoint" EXACT [GO:0044878] synonym: "abnormal cytokinesis checkpoint activation" RELATED [PomBase:mah] synonym: "abnormal mitotic cell cycle cytokinesis checkpoint" EXACT [PomBase:mah] is_a: FYPO:0001704 ! abnormal mitotic cell cycle checkpoint intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0044878 ! cytokinesis checkpoint intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0044878 ! cytokinesis checkpoint relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-10-15T10:05:28Z [Term] id: FYPO:0003831 name: abolished response to cytokinesis checkpoint signaling def: "A cellular process phenotype in which a mitotic cell cycle arrest that normally occurs in response to the cytokinesis after mitosis checkpoint does not occur. The cytokinesis after mitosis checkpoint normally delays the G2/M transition of a mitotic cell cycle if cytokinesis was not completed correctly in the previous cell cycle. Abolished arrest may result from a problem with detection of conditions that normally trigger a checkpoint, transduction of the checkpoint signal, or the response to the checkpoint signal." [GO:0044878, PomBase:mah] comment: May indicate that a cell cycle checkpoint is not activated under conditions that normally trigger checkpoint signaling and subsequent cell cycle arrest. synonym: "abolished cytokinesis after mitosis checkpoint" RELATED [PomBase:mah] synonym: "abolished cytokinesis checkpoint activation" RELATED [PomBase:mah] synonym: "abolished cytokinesis checkpoint arrest" RELATED [PomBase:mah] synonym: "abolished response to cytokinesis after mitosis checkpoint signaling" EXACT [PomBase:mah] synonym: "abolished response to mitotic cell cycle cytokinesis checkpoint signaling" EXACT [PomBase:mah] synonym: "cell cycle arrest resulting from cytokinesis checkpoint activation abolished" EXACT [PomBase:mah] is_a: FYPO:0003830 ! abnormal cytokinesis checkpoint created_by: midori creation_date: 2014-10-15T10:24:37Z [Term] id: FYPO:0003832 name: normal cell cycle def: "A cellular process phenotype in which cell cycle progression is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "cell cycle progression: normal" EXACT [SGD:phenotype_annotation] synonym: "normal cell cycle progression" EXACT [PomBase:mah] synonym: "normal cell-division cycle" EXACT [GO:0007049, PomBase:mah] is_a: FYPO:0001319 ! normal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0007049 ! cell cycle intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0007049 ! cell cycle relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-10-15T11:01:20Z [Term] id: FYPO:0003833 name: normal cell cycle phase def: "A cellular process phenotype in which a cell proceeds normally through a specific cell cycle phase. A cell cycle phase is any of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GO:0022403, PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate is_a: FYPO:0003832 ! normal cell cycle intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0022403 ! cell cycle phase intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0022403 ! cell cycle phase relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-10-15T11:04:03Z [Term] id: FYPO:0003834 name: normal duration of meiotic interphase def: "A cell cycle phenotype in the duration of meiotic interphase, which begins after cytokinesis and ends when meiotic prophase begins, is normal (i.e. indistinguishable from wild type)." [GO:0051328, PomBase:mah] is_a: FYPO:0003833 ! normal cell cycle phase is_a: PATO:0001309 ! duration intersection_of: PATO:0001309 ! duration intersection_of: inheres_in GO:0051328 ! meiotic interphase intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0051328 ! meiotic interphase relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-10-15T11:05:28Z [Term] id: FYPO:0003835 name: normal horsetail movement def: "A cellular process phenotype in which horsetail movement is normal (i.e. indistinguishable from wild type). Horsetail movement is the oscillatory movement of the nucleus that takes place during meiotic prophase I." [GO:0030989, PomBase:mah] comment: Consider also annotating to 'normal horsetail nucleus morphology' (FYPO:0003562). synonym: "normal dynein-driven meiotic oscillatory nuclear movement" EXACT [GO:0030989] synonym: "normal horsetail nuclear movement" EXACT [GO:0030989] is_a: FYPO:0001071 ! normal transport is_a: FYPO:0001389 ! normal nucleus localization intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0030989 ! dynein-driven meiotic oscillatory nuclear movement intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0030989 ! dynein-driven meiotic oscillatory nuclear movement relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-10-15T11:08:48Z [Term] id: FYPO:0003836 name: decreased RNA polymerase II carboxy-terminal domain kinase activity def: "A molecular function phenotype in which the observed rate of RNA polymerase II carboxy-terminal domain kinase activity is decreased." [PomBase:mah] synonym: "reduced RNA polymerase II carboxy-terminal domain kinase activity" EXACT [PomBase:mah] is_a: FYPO:0001382 ! decreased protein kinase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0008353 ! RNA polymerase II carboxy-terminal domain kinase activity relationship: inheres_in GO:0008353 ! RNA polymerase II carboxy-terminal domain kinase activity created_by: midori creation_date: 2014-10-15T11:28:58Z [Term] id: FYPO:0003837 name: increased RNA polymerase II carboxy-terminal domain kinase activity def: "A molecular function phenotype in which the observed rate of RNA polymerase II carboxy-terminal domain kinase activity is increased." [PomBase:mah] is_a: FYPO:0002700 ! increased protein kinase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0008353 ! RNA polymerase II carboxy-terminal domain kinase activity relationship: inheres_in GO:0008353 ! RNA polymerase II carboxy-terminal domain kinase activity created_by: midori creation_date: 2014-10-15T11:29:13Z [Term] id: FYPO:0003838 name: abolished actomyosin contractile ring contraction def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which actomyosin contractile ring contraction does not occur. Contractile ring contraction is the part of cytokinesis in which the actomyosin contractile ring constricts." [GO:1902404, PomBase:mah] synonym: "abolished actomyosin contractile ring constriction" EXACT [PomBase:mah] synonym: "abolished actomyosin contractile ring contraction during vegetative growth" EXACT [PomBase:mah] synonym: "abolished cytokinetic contractile ring contraction" EXACT [PomBase:vw] synonym: "abolished mitotic actomyosin contractile ring contraction" EXACT [GO:1902404, PomBase:mah] synonym: "abolished mitotic contractile ring contraction" EXACT [PomBase:mah] synonym: "actomyosin contractile ring contraction abolished" EXACT [PomBase:mah] is_a: FYPO:0001364 ! abnormal actomyosin contractile ring contraction is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1902404 ! mitotic actomyosin contractile ring contraction relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1902404 ! mitotic actomyosin contractile ring contraction created_by: midori creation_date: 2014-10-15T13:54:53Z [Term] id: FYPO:0003839 name: abnormal protein localization to nucleolus during mitotic M phase def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleolus is abnormal during M phase of the mitotic cell cycle." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to nucleolus during mitotic M phase" EXACT [PomBase:mah] synonym: "abnormal protein localization to nucleolus during M phase of mitotic cell cycle" EXACT [PomBase:mah] synonym: "abnormal protein localization to nucleolus during mitotic M phase during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000443 ! abnormal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0000087 ! mitotic M phase intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902570 ! protein localization to nucleolus intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0000087 ! mitotic M phase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902570 ! protein localization to nucleolus relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-10-15T14:03:34Z [Term] id: FYPO:0003840 name: sensitive to carbendazim def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to carbendazim (mecarzole; MBC). Cells stop growing (and may die) at a concentration of carbendazim that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to carbendazim" EXACT [PomBase:mah] synonym: "sensitive to carbendazim during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to carbendazim during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to MBC" EXACT [CHEBI:3392, PomBase:mah] synonym: "sensitive to mecarzole" EXACT [CHEBI:3392] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:3392 ! carbendazim relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:3392 ! carbendazim created_by: midori creation_date: 2014-10-15T14:20:59Z [Term] id: FYPO:0003841 name: decreased protein localization to mitotic spindle midzone def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the mitotic spindle midzone is decreased. The mitotic spindle midzone is the area in the center of the mitotic spindle where the spindle microtubules from opposite poles overlap." [GO:1902967, GO:1990023, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to mitotic spindle midzone" EXACT [PomBase:mah] synonym: "decreased protein localization to spindle midzone during mitosis" EXACT [PomBase:mah] synonym: "decreased protein localization to spindle midzone during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to mitotic spindle midzone" EXACT [PomBase:mah] is_a: FYPO:0002825 ! decreased protein localization to mitotic spindle intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902967 ! protein localization to mitotic spindle midzone relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902967 ! protein localization to mitotic spindle midzone created_by: midori creation_date: 2014-10-16T11:19:29Z [Term] id: FYPO:0003842 name: inviable following spore germination, single cell division, abolished chromosome segregation def: "A phenotype in which a spore germinates to produce a cell that undergoes a single round of cell division in which chromosome segregation does not occur, and then dies." [PomBase:mah] synonym: "essential; germinating spore, single cell division, abolished chromosome segregation" RELATED [PomBase:jh, PomBase:vw] synonym: "inviable following spore germination, single cell division, abolished chromosome segregation" EXACT [PomBase:mah] synonym: "inviable germinated spore, single cell division, abolished chromosome segregation" EXACT [PomBase:mah] is_a: FYPO:0002280 ! inviable after spore germination, single cell division created_by: midori creation_date: 2014-10-16T11:30:08Z [Term] id: FYPO:0003843 name: inviable following spore germination, single cell division, unequal chromosome segregation def: "A phenotype in which a spore germinates to produce a cell that undergoes a single round of cell division during which chromosomes segregate unequally, and then dies." [PomBase:mah] synonym: "essential; germinating spore, single cell division, unequal chromosome segregation" RELATED [PomBase:jh, PomBase:vw] synonym: "inviable following spore germination, single cell division, unequal chromosome segregation" EXACT [PomBase:mah] synonym: "inviable germinated spore, single cell division, unequal chromosome segregation" EXACT [PomBase:mah] is_a: FYPO:0002280 ! inviable after spore germination, single cell division created_by: midori creation_date: 2014-10-16T11:37:02Z [Term] id: FYPO:0003844 name: abolished mitotic chromosome condensation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitotic chromosome condensation does not occur." [PomBase:mah] synonym: "abolished mitotic chromosome condensation during vegetative growth" EXACT [PomBase:mah] synonym: "mitotic chromosome condensation abolished" EXACT [PomBase:mah] is_a: FYPO:0000159 ! abnormal chromosome condensation is_a: FYPO:0001346 ! DNA metabolism phenotype during vegetative growth is_a: FYPO:0001353 ! abnormal cellular component organization during vegetative growth is_a: FYPO:0001363 ! abnormal metabolic process during vegetative growth is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0007076 ! mitotic chromosome condensation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0007076 ! mitotic chromosome condensation created_by: midori creation_date: 2014-10-16T11:42:21Z [Term] id: FYPO:0003845 name: normal protein localization to prospore membrane def: "A transport phenotype in which protein localization to the prospore membrane is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: Encompasses both targeting of proteins to the prospore membrane where they are not normally found and decreased or no targeting of proteins normally found in the prospore membrane. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to prospore membrane" EXACT [PomBase:mah] synonym: "normal protein localization to forespore membrane" EXACT [PomBase:mah] is_a: FYPO:0003627 ! normal protein localization intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:1902657 ! protein localization to prospore membrane intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:1902657 ! protein localization to prospore membrane relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-10-16T11:58:00Z [Term] id: FYPO:0003846 name: spores sensitive to acetone def: "A cell phenotype in which spores germinate to a lower extent than wild type following exposure to acetone." [PMID:24727291, PomBase:mah] is_a: FYPO:0003037 ! abnormal cell phenotype created_by: midori creation_date: 2014-10-16T12:02:04Z [Term] id: FYPO:0003847 name: h- specific sterility def: "A cellular process phenotype in which conjugation does not occur in cells of the h- mating type." [PMID:24727291, PomBase:mah] synonym: "h--specific sterility" EXACT [PomBase:mah] synonym: "h-minus-specific mating defect" RELATED [PMID:24727291] synonym: "h-minus-specific sterility" EXACT [PomBase:mah] is_a: FYPO:0000280 ! sterile created_by: midori creation_date: 2014-10-16T12:03:33Z [Term] id: FYPO:0003848 name: sensitive to hydrazinocurcumin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to hydrazinocurcumin. Cells stop growing (and may die) at a concentration of hydrazinocurcumin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to hydrazinocurcumin" EXACT [PomBase:mah] synonym: "sensitive to hydrazinocurcumin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to hydrazinocurcumin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:84340 ! hydrazinocurcumin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:84340 ! hydrazinocurcumin created_by: midori creation_date: 2014-10-16T13:30:30Z [Term] id: FYPO:0003849 name: normal growth on fluconazole def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing fluconazole." [PomBase:mah] synonym: "normal cell population growth in presence of fluconazole" EXACT [PomBase:mah] synonym: "normal cell population growth on fluconazole" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to fluconazole" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on fluconazole" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:46081 ! fluconazole relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:46081 ! fluconazole created_by: midori creation_date: 2014-10-16T14:32:42Z [Term] id: FYPO:0003850 name: normal growth on oligomycin def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing an oligomycin antibiotic." [PomBase:mah] synonym: "normal cell population growth in presence of oligomycin" EXACT [PomBase:mah] synonym: "normal cell population growth on oligomycin" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to oligomycin" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on oligomycin" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:25675 ! oligomycin relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:25675 ! oligomycin created_by: midori creation_date: 2014-10-16T14:33:29Z [Term] id: FYPO:0003851 name: normal growth on MTT def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide)." [PomBase:mah] synonym: "normal cell population growth in presence of MTT" EXACT [PomBase:mah] synonym: "normal cell population growth on MTT" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to MTT" RELATED [PomBase:al, PomBase:mah] synonym: "normal growth on 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide" EXACT [CHEBI:53233] synonym: "normal vegetative cell population growth on MTT" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:53233 ! 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:53233 ! 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide created_by: midori creation_date: 2014-10-16T14:34:37Z [Term] id: FYPO:0003852 name: normal growth on FR901464 def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing FR901464." [PomBase:mah] synonym: "normal cell population growth in presence of FR901464" EXACT [PomBase:mah] synonym: "normal cell population growth on FR901464" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to FR901464" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on FR901464" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:65915 ! FR901464 relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:65915 ! FR901464 created_by: midori creation_date: 2014-10-16T14:44:20Z [Term] id: FYPO:0003853 name: sensitive to fluconazole def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to fluconazole. Cells stop growing (and may die) at a concentration of fluconazole that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to fluconazole" EXACT [PomBase:mah] synonym: "sensitive to fluconazole during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to fluconazole during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:46081 ! fluconazole relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:46081 ! fluconazole created_by: midori creation_date: 2014-10-16T14:45:19Z [Term] id: FYPO:0003854 name: sensitive to oligomycin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to an oligomycin antibiotic. Cells stop growing (and may die) at a concentration of oligomycin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to oligomycin" EXACT [PomBase:mah] synonym: "sensitive to oligomycin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to oligomycin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:25675 ! oligomycin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:25675 ! oligomycin created_by: midori creation_date: 2014-10-16T14:45:52Z [Term] id: FYPO:0003855 name: sensitive to MTT def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide). Cells stop growing (and may die) at a concentration of MTT that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to MTT" EXACT [PomBase:mah] synonym: "sensitive to 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide" EXACT [CHEBI:53233] synonym: "sensitive to MTT during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to MTT during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:53233 ! 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:53233 ! 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide created_by: midori creation_date: 2014-10-16T14:46:36Z [Term] id: FYPO:0003856 name: sensitive to FR901464 def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to FR901464. Cells stop growing (and may die) at a concentration of FR901464 that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to FR901464" EXACT [PomBase:mah] synonym: "sensitive to FR901464 during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to FR901464 during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:65915 ! FR901464 relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:65915 ! FR901464 created_by: midori creation_date: 2014-10-16T14:48:53Z [Term] id: FYPO:0003857 name: sensitive to mevastatin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to mevastatin. Cells stop growing (and may die) at a concentration of mevastatin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to mevastatin" EXACT [PomBase:mah] synonym: "sensitive to compactin" EXACT [CHEBI:34848] synonym: "sensitive to mevastatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to mevastatin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:34848 ! mevastatin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:34848 ! mevastatin created_by: midori creation_date: 2014-10-16T14:49:41Z [Term] id: FYPO:0003858 name: sensitive to etoposide def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to etoposide. Cells stop growing (and may die) at a concentration of etoposide that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to etoposide" EXACT [PomBase:mah] synonym: "sensitive to etoposide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to etoposide during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:4911 ! etoposide relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:4911 ! etoposide created_by: midori creation_date: 2014-10-16T14:51:08Z [Term] id: FYPO:0003859 name: sensitive to wortmannin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to wortmannin. Cells stop growing (and may die) at a concentration of wortmannin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to wortmannin" EXACT [PomBase:mah] synonym: "sensitive to wortmannin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to wortmannin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:52289 ! wortmannin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:52289 ! wortmannin created_by: midori creation_date: 2014-10-16T14:51:47Z [Term] id: FYPO:0003860 name: resistance to miconazole def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of miconazole than normal." [PomBase:mah] synonym: "resistance to miconazole during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to miconazole during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to miconazole" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:6923 ! miconazole relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:6923 ! miconazole created_by: midori creation_date: 2014-10-16T14:53:07Z [Term] id: FYPO:0003861 name: normal acidification of growth medium in stationary phase def: "A cell population phenotype in which the pH of a growth medium in which a cell population grows to stationary phase decreases to a normal (i.e. indistinguishable from wild type) extent." [PMID:23874875, PomBase:mah] is_a: FYPO:0000003 ! cell population phenotype is_a: FYPO:0000257 ! normal phenotype created_by: midori creation_date: 2014-10-16T15:08:21Z [Term] id: FYPO:0003862 name: increased protein oxidation in stationary phase def: "A cellular process phenotype in which the occurrence of oxidation of one or more specific proteins, or of specific protein sites, is increased, resulting in the accumulation of proteins with oxidative modifications including carbonylated proteins, in cells in a population in stationary phase." [PMID:17986764, PomBase:mah] synonym: "accumulation of carbonylated proteins in stationary phase" RELATED [PomBase:mah] synonym: "increased level of disulfides in stationary phase" RELATED [PomBase:al] synonym: "increased level of oxidised thiols in proteins in stationary phase" RELATED [PomBase:al] synonym: "increased level of oxidized protein thiols in stationary phase" RELATED [PomBase:mah] is_a: FYPO:0003863 ! increased protein oxidation created_by: midori creation_date: 2014-10-16T15:12:03Z [Term] id: FYPO:0003863 name: increased protein oxidation def: "A cellular process phenotype in which the occurrence of oxidation of one or more specific proteins, or of specific protein sites, is increased, resulting in the accumulation of proteins with oxidative modifications including carbonylated proteins." [PomBase:mah] synonym: "accumulation of carbonylated proteins" RELATED [PomBase:mah] synonym: "increased level of disulfides" RELATED [PomBase:al] synonym: "increased level of oxidised thiols in proteins" RELATED [PomBase:al] synonym: "increased level of oxidized protein thiols" RELATED [PomBase:mah] is_a: FYPO:0002499 ! increased protein modification intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0018158 ! protein oxidation relationship: inheres_in GO:0018158 ! protein oxidation created_by: midori creation_date: 2014-10-16T15:14:29Z [Term] id: FYPO:0003864 name: decreased level of substance in cell during G0 def: "A cell phenotype in which the amount a specific substance measured in a cell is lower than normal when the cell is in G0 phase." [PomBase:mah] synonym: "decreased accumulation of substance in cell during G0" RELATED [PomBase:mah] synonym: "decreased level of substance in cell during cell quiescence" EXACT [PomBase:mah] synonym: "decreased substance level during G0" EXACT [PomBase:vw] synonym: "reduced level of substance in cell during G0" EXACT [PomBase:mah] is_a: FYPO:0000991 ! decreased level of substance in cell intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0044838 ! cell quiescence intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:24431 ! chemical entity relationship: exists_during GO:0044838 ! cell quiescence relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:24431 ! chemical entity created_by: midori creation_date: 2014-10-16T15:57:29Z [Term] id: FYPO:0003865 name: decreased protein level during G0 def: "A cell phenotype in which the amount of protein measured in a cell is lower than normal when the cell is in G0 phase. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability as well as changes in translation. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein accumulation during G0" RELATED [PomBase:mah] synonym: "decreased protein level during cell quiescence" EXACT [PomBase:mah] synonym: "reduced protein level during G0" EXACT [PomBase:mah] is_a: FYPO:0000835 ! decreased protein level is_a: FYPO:0003864 ! decreased level of substance in cell during G0 intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0044838 ! cell quiescence intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0044838 ! cell quiescence relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2014-10-16T16:00:08Z [Term] id: FYPO:0003866 name: increased protein level during G0 def: "A cell phenotype in which the amount of protein measured in a cell when the cell is in G0 phase is higher than normal. Total protein or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability as well as changes in translation. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein accumulation during G0" RELATED [PomBase:mah] synonym: "increased protein level during cell quiescence" EXACT [PomBase:mah] is_a: FYPO:0000836 ! increased protein level is_a: FYPO:0002949 ! increased level of substance in cell during G0 intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0044838 ! cell quiescence intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0044838 ! cell quiescence relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2014-10-16T16:00:59Z [Term] id: FYPO:0003867 name: increased level of ubiquitinated protein in cell during G0 def: "A cell phenotype in which the amount of ubiquitinated protein measured in the cell is higher than normal when the cell is in G0 phase. Total protein or a specific protein may be affected." [PMID:20133687, PomBase:mah] comment: Consider also annotating to 'increased protein ubiquitination' (FYPO:0002082) if the experiment directly assays the ubiquitination reaction(s). synonym: "increased accumulation of ubiquitinated protein in cell during G0" RELATED [PomBase:al] synonym: "increased level of ubiquitinated protein in cell during cell quiescence" EXACT [PomBase:mah] synonym: "increased ubiquitinated protein level during G0" EXACT [PomBase:mah] is_a: FYPO:0003866 ! increased protein level during G0 intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0044838 ! cell quiescence intersection_of: inheres_in GO:0005776 ! autophagosome intersection_of: towards PR:000037077 relationship: exists_during GO:0044838 ! cell quiescence relationship: inheres_in GO:0005776 ! autophagosome relationship: towards PR:000037077 created_by: midori creation_date: 2014-10-16T16:02:23Z [Term] id: FYPO:0003868 name: mitochondria present in decreased numbers during G0 def: "A physical cellular phenotype in which a cell contains fewer mitochondria than normal during G0 phase." [PMID:20133687, PomBase:mah] synonym: "decreased number of mitochondria during G0" EXACT [PomBase:mah] synonym: "fewer mitochondria during G0" EXACT [PomBase:mah] synonym: "mitochondria present in decreased numbers during cell quiescence" EXACT [PomBase:mah] synonym: "mitochondria present in reduced numbers during G0" EXACT [PomBase:mah] is_a: FYPO:0000287 ! abnormal subcellular component is_a: PATO:0002001 ! has fewer parts of type intersection_of: PATO:0002001 ! has fewer parts of type intersection_of: exists_during GO:0044838 ! cell quiescence intersection_of: towards GO:0005739 ! mitochondrion relationship: exists_during GO:0044838 ! cell quiescence relationship: towards GO:0005739 ! mitochondrion created_by: midori creation_date: 2014-10-16T16:08:56Z [Term] id: FYPO:0003869 name: increased level of hydrogen peroxide-induced proteins during G0 def: "A cell phenotype observed in which the amount of protein encoded by genes normally induced by exposure to hydrogen peroxide measured in a cell is higher than normal when the cell is in G0 phase." [PMID:20133687, PomBase:mah] synonym: "increased level of H2O2-induced proteins during G0" EXACT [PomBase:mah] synonym: "increased level of proteins expressed during cellular response to hydrogen peroxide during G0" EXACT [PomBase:mah] synonym: "increased level of proteins induced by hydrogen peroxide during G0" EXACT [PomBase:mah] synonym: "increased protein level of genes (normally) induced during H2O2 stress during G0" EXACT [PomBase:al] is_a: FYPO:0003866 ! increased protein level during G0 created_by: midori creation_date: 2014-10-16T16:17:59Z [Term] id: FYPO:0003870 name: increased level of cadmium-induced proteins during G0 def: "A cell phenotype observed in which the amount of protein encoded by genes normally induced by exposure to cadmium ions measured in a cell is higher than normal when the cell is in G0 phase." [PMID:20133687, PomBase:mah] synonym: "increased level of proteins expressed during cellular response to cadmium during G0" EXACT [PomBase:mah] synonym: "increased level of proteins induced by cadmium during G0" EXACT [PomBase:mah] synonym: "increased protein level of genes (normally) induced during cadmium stress during G0" EXACT [PomBase:al] is_a: FYPO:0003866 ! increased protein level during G0 created_by: midori creation_date: 2014-10-16T16:21:36Z [Term] id: FYPO:0003871 name: abnormal chromatin organization during G0 def: "A cellular process phenotype in which any process of chromatin organization is abnormal when the cell is in G0 phase. Chromatin organization results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GO:0006325, PMID:20133687, PomBase:mah] synonym: "abnormal chromatin organisation during G0" EXACT [PomBase:mah] synonym: "abnormal chromatin organization during cell quiescence" EXACT [PomBase:mah] is_a: FYPO:0000642 ! abnormal chromatin organization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0044838 ! cell quiescence intersection_of: inheres_in_part_of GO:0006325 ! chromatin organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0044838 ! cell quiescence relationship: inheres_in_part_of GO:0006325 ! chromatin organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-10-16T16:23:04Z [Term] id: FYPO:0003872 name: increased glutathione level during G0 def: "A cell phenotype in which the amount of glutathione measured in a cell is lower than normal when the cell is in G0 phase." [PMID:20133687, PomBase:mah] synonym: "increased glutathione accumulation during G0" RELATED [PomBase:mah] synonym: "increased glutathione level during cell quiescence" EXACT [PomBase:mah] is_a: FYPO:0002949 ! increased level of substance in cell during G0 intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0044838 ! cell quiescence intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:16856 ! glutathione relationship: exists_during GO:0044838 ! cell quiescence relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:16856 ! glutathione created_by: midori creation_date: 2014-10-16T16:24:07Z [Term] id: FYPO:0003873 name: increased reactive oxygen species level during G0 def: "A cell phenotype in which the amount of reactive oxygen species (ROS) measured in a cell is lower than normal when the cell is in G0 phase." [PMID:20133687, PomBase:mah] synonym: "increased cellular ROS level during G0" EXACT [PomBase:mah] synonym: "increased reactive oxygen species accumulation during G0" RELATED [PomBase:mah] synonym: "increased reactive oxygen species level during cell quiescence" EXACT [PomBase:mah] is_a: FYPO:0002142 ! altered cellular reactive oxygen species level is_a: FYPO:0002949 ! increased level of substance in cell during G0 intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0044838 ! cell quiescence intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:26523 ! reactive oxygen species relationship: exists_during GO:0044838 ! cell quiescence relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:26523 ! reactive oxygen species created_by: midori creation_date: 2014-10-16T16:31:04Z [Term] id: FYPO:0003874 name: abnormal dense body present in nucleus during G0 def: "A physical cellular phenotype observed in G0 phase in which the nucleus contains one or more structures of great electron density that are not found in wild type cells." [PMID:20133687, PomBase:mah] is_a: FYPO:0002403 ! abnormal nucleus created_by: midori creation_date: 2014-10-16T16:35:52Z [Term] id: FYPO:0003875 name: inviable elongated cell with mitotic G2/M transition delay and cell cycle arrest in M phase def: "A cell phenotype in which a cell is elongated and inviable, and prior to death the cell undergoes a mitotic G2/M transition that begins later than normal, followed by cell cycle arrest in M phase." [PMID:114458769, PomBase:mah, PomBase:vw] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "elongated inviable cell with mitotic G2/M transition delay and cell cycle arrest in M phase" EXACT [PomBase:mah] synonym: "elongated inviable cell with mitotic G2/M transition delay and cell cycle arrest in M phase during vegetative growth" EXACT [PomBase:mah] synonym: "elongated inviable cell with mitotic G2/M transition delay and M phase arrest" EXACT [PomBase:vw] synonym: "long inviable cell with mitotic G2/M transition delay and cell cycle arrest in M phase" EXACT [PomBase:vw] is_a: FYPO:0001490 ! inviable elongated vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000012 ! mitotic G2/M transition delay intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000608 ! abnormal cell cycle arrest in mitotic M phase intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000012 ! mitotic G2/M transition delay relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000608 ! abnormal cell cycle arrest in mitotic M phase relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2014-10-21T12:04:07Z [Term] id: FYPO:0003876 name: normal cytokinesis checkpoint def: "A cell cycle checkpoint phenotype in which the cytokinesis after mitosis checkpoint of a mitotic cell cycle is normal (i.e. indistinguishable from wild type). The cytokinesis after mitosis checkpoint normally delays the G2/M transition of a mitotic cell cycle if cytokinesis was not completed correctly in the previous cell cycle." [GO:0044878, PomBase:mah] synonym: "normal cytokinesis after mitosis checkpoint" EXACT [GO:0044878] synonym: "normal cytokinesis checkpoint activation" RELATED [PomBase:mah] synonym: "normal mitotic cell cycle cytokinesis checkpoint" EXACT [PomBase:mah] synonym: "normally activated cytokinesis checkpoint" RELATED [PomBase:vw] is_a: FYPO:0001703 ! normal mitotic cell cycle checkpoint intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0044878 ! cytokinesis checkpoint intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0044878 ! cytokinesis checkpoint relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-10-21T12:15:43Z [Term] id: FYPO:0003877 name: single cell division prior to G0 entry def: "A cellular process phenotype in which a cell undergoes one round of cell division, instead of the normal two rounds, prior to entering quiescence (G0)." [PMID:20133687, PomBase:al, PomBase:mah] synonym: "G0 to G1 transition after single cell division" EXACT [PomBase:mah] synonym: "one cell division prior to G0 entry" EXACT [PomBase:al] is_a: FYPO:0002955 ! abnormal G0 to G1 transition created_by: midori creation_date: 2014-10-21T12:22:15Z [Term] id: FYPO:0003878 name: sensitive to monensin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to monensin. Cells stop growing (and may die) at a concentration of monensin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to monensin" EXACT [PomBase:mah] synonym: "sensitive to monensin A" NARROW [CHEBI:27617] synonym: "sensitive to monensin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to monensin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:27617 ! monensin A relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:27617 ! monensin A created_by: midori creation_date: 2014-10-21T12:25:35Z [Term] id: FYPO:0003879 name: delayed age-related vacuolar changes def: "A cell phenotype in which changes in vacuolar morphology or function associated with cell aging begin later than normal. As cells age, vacuoles become fragmented and vacuolar acidity decreases. In a mutant, these changes may occur to a lesser extent as well as later than in wild type." [PMID:23521895, PomBase:mah] synonym: "delayed vacuolar changes during cell aging" EXACT [PomBase:mah] synonym: "increased vacuolar maintenance in aged cells" RELATED [PomBase:al] is_a: FYPO:0003037 ! abnormal cell phenotype created_by: midori creation_date: 2014-10-21T13:21:51Z [Term] id: FYPO:0003880 name: decreased chromatin silencing at telomere def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of chromatin silencing at telomeric regions is decreased." [PomBase:mah] synonym: "decreased chromatin silencing at telomere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased chromatin silencing at telomere during vegetative growth" EXACT [PomBase:mah] synonym: "reduced chromatin silencing at telomere" EXACT [PomBase:mah] is_a: FYPO:0002353 ! decreased chromatin silencing intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006348 ! chromatin silencing at telomere relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006348 ! chromatin silencing at telomere created_by: midori creation_date: 2014-10-21T13:36:57Z [Term] id: FYPO:0003881 name: mtDNA absent from cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of mitochondrial DNA measured in a cell is too low to detect." [PomBase:mah] synonym: "absent mtDNA" EXACT [PomBase:vw] synonym: "mitochondrial DNA absent from cell" EXACT [PMID:2894829] synonym: "mtDNA absent from cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "mtDNA absent from cell during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001208 ! substance absent from cell during vegetative growth is_a: FYPO:0003769 ! decreased cellular mtDNA level created_by: midori creation_date: 2014-10-21T13:43:19Z [Term] id: FYPO:0003882 name: increased cyclosporin A binding def: "A molecular function phenotype in which occurrence of cyclosporin A binding by a gene product (usually a protein) in a mutant is increased. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] comment: This term can mean that the mutated gene product itself binds cyclosporin A more than wild type, or that a mutation in one gene increases cyclosporin A binding by a second gene product. When using this term, it is therefore recommended to note the specific protein(s) affected. is_a: FYPO:0000707 ! abnormal molecular function is_a: FYPO:0001092 ! binding phenotype is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0016018 ! cyclosporin A binding relationship: inheres_in GO:0016018 ! cyclosporin A binding created_by: midori creation_date: 2014-10-21T13:58:50Z [Term] id: FYPO:0003883 name: increased sanglifehrin A binding def: "A molecular function phenotype in which occurrence of sanglifehrin A binding by a gene product (usually a protein) in a mutant is increased. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] comment: This term can mean that the mutated gene product itself binds sanglifehrin A more than wild type, or that a mutation in one gene increases sanglifehrin A binding by a second gene product. When using this term, it is therefore recommended to note the specific protein(s) affected. is_a: FYPO:0000707 ! abnormal molecular function is_a: FYPO:0001092 ! binding phenotype created_by: midori creation_date: 2014-10-21T13:59:37Z [Term] id: FYPO:0003884 name: abnormal NAD(P)H oxidase activity def: "A molecular function phenotype in which the observed rate of NAD(P)H oxidase activity is abnormal." [PomBase:mah] is_a: FYPO:0000689 ! abnormal oxidoreductase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0016174 ! NAD(P)H oxidase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0016174 ! NAD(P)H oxidase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-10-21T14:05:49Z [Term] id: FYPO:0003885 name: decreased NAD(P)H oxidase activity def: "A molecular function phenotype in which the observed rate of NAD(P)H oxidase activity is decreased." [PomBase:mah] synonym: "reduced NAD(P)H oxidase activity" EXACT [PomBase:mah] is_a: FYPO:0000690 ! decreased oxidoreductase activity is_a: FYPO:0003884 ! abnormal NAD(P)H oxidase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0016174 ! NAD(P)H oxidase activity relationship: inheres_in GO:0016174 ! NAD(P)H oxidase activity created_by: midori creation_date: 2014-10-21T14:05:54Z [Term] id: FYPO:0003886 name: abnormal endocytosis def: "A cellular process phenotype in which endocytosis is abnormal. Endocytosis is a vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. A phenotype may affect endocytosis of all cargoes, or of specific cargo such as a particular protein." [GO:0006897, PomBase:mah] synonym: "abnormal actin-mediated endocytosis" EXACT [PomBase:vw] synonym: "abnormal protein internalization" NARROW [PomBase:mah] synonym: "endocytosis defects" EXACT [PomBase:mah] synonym: "endocytosis: abnormal" EXACT [SGD:phenotype_annotation] is_a: FYPO:0001720 ! abnormal transport intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0006897 ! endocytosis intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0006897 ! endocytosis relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-10-21T14:16:25Z [Term] id: FYPO:0003887 name: abolished endocytosis during meiotic cell cycle def: "A cellular process phenotype in which endocytosis does not occur during a meiotic cell cycle. A phenotype may affect endocytosis of all cargoes, or of specific cargo such as a particular protein." [PomBase:mah] synonym: "abolished actin-mediated endocytosis during meiotic cell cycle" EXACT [PomBase:vw] synonym: "abolished protein internalization during meiotic cell cycle" NARROW [PomBase:vw] synonym: "absent endocytosis during meiotic cell cycle" EXACT [PomBase:mah] synonym: "endocytosis abolished during meiotic cell cycle" EXACT [PomBase:mah] synonym: "endocytosis: absent during meiotic cell cycle" EXACT [SGD:phenotype_annotation] is_a: FYPO:0003886 ! abnormal endocytosis is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0051321 ! meiotic cell cycle intersection_of: towards GO:0006897 ! endocytosis relationship: during GO:0051321 ! meiotic cell cycle relationship: towards GO:0006897 ! endocytosis created_by: midori creation_date: 2014-10-21T14:17:02Z [Term] id: FYPO:0003888 name: increased cell wall thickness at new end during vegetative growth def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the fungal-type cell wall is thicker than normal at the new end of the cell." [PMID:10547441, PomBase:mah] synonym: "increased cell wall thickness at new end during mitotic cell cycle" RELATED [PomBase:mah] synonym: "thickened cell wall at new end during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001035 ! increased cell wall thickness during vegetative growth created_by: midori creation_date: 2014-10-21T14:27:56Z [Term] id: FYPO:0003889 name: decreased cell wall thickness at old end during vegetative growth def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the fungal-type cell wall is thinner than normal at the old end of the cell." [PMID:10547441, PomBase:mah] synonym: "decreased cell wall thickness at old end during mitotic cell cycle" RELATED [PomBase:mah] synonym: "reduced cell wall thickness at old end during vegetative growth" EXACT [PomBase:mah] synonym: "thin cell wall at old end during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002163 ! decreased cell wall thickness during vegetative growth created_by: midori creation_date: 2014-10-21T14:29:12Z [Term] id: FYPO:0003890 name: abnormal primary cell septum biogenesis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which primary cell septum biogenesis is abnormal. Primary cell septum biogenesis results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of the primary cell septum during cytokinesis." [PomBase:mah] comment: Consider also annotating to 'abnormal contractile ring localization' (FYPO:0000033) because if the contractile ring forms in an abnormal location, the septum will also do so. The positions of both the contractile ring and the septum are determined by the processes that select the site of cell division. synonym: "abnormal primary cell septum biogenesis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal primary cell septum biogenesis during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal primary cell septum formation" RELATED [PomBase:mah] synonym: "abnormal primary septum biogenesis" EXACT [PomBase:mah] is_a: FYPO:0000117 ! abnormal septation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0031671 ! primary cell septum biogenesis intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0031671 ! primary cell septum biogenesis relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-10-21T14:30:09Z [Term] id: FYPO:0003891 name: normal intragenic meiotic recombination def: "A cellular process phenotype in which the occurrence of intragenic meiotic recombination is normal (i.e. indistinguishable from wild type). Intragenic meiotic recombination can result in gene conversion events." [PMID:11104907, PomBase:mah] synonym: "normal meiotic intragenic recombination" EXACT [PomBase:al] is_a: FYPO:0000627 ! normal cellular process created_by: midori creation_date: 2014-10-21T14:35:38Z [Term] id: FYPO:0003892 name: abnormal error-prone translesion synthesis def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which error-prone translesion synthesis is abnormal. Error-prone translesion synthesis a DNA repair process that results in the conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication." [GO:0042276, PomBase:mah] synonym: "abnormal error-prone translesion synthesis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal error-prone translesion synthesis during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000188 ! abnormal DNA repair intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0042276 ! error-prone translesion synthesis intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0042276 ! error-prone translesion synthesis relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-10-21T15:13:48Z [Term] id: FYPO:0003893 name: abolished incorporation of ATP opposite 8-oxo-dG def: "A cellular process phenotype in which the insertion of ATP opposite an 8-oxo-7,8-dihydroguanosine (8oxodG) residue in DNA does not occur. Normally, if a guanosine residue is damaged to form 8oxodG, ATP can be misincorporated into the opposite strand to form an 8oxodG:AMP mispair that is subsequently removed." [PMID:25106870, PomBase:mah] synonym: "abolished incorporation of ATP opposite 8-oxo-7,8-dihydroguanosine" EXACT [PomBase:mah] synonym: "abolished insertion of ATP opposite 8-oxo-dG" EXACT [PomBase:mah] synonym: "incorporation of ATP opposite 8-oxo-dG abolished" EXACT [PomBase:mah] is_a: FYPO:0003892 ! abnormal error-prone translesion synthesis created_by: midori creation_date: 2014-10-21T15:15:32Z [Term] id: FYPO:0003894 name: sensitive to rotenone def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to rotenone. Cells stop growing (and may die) at a concentration of rotenone that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to rotenone" EXACT [PomBase:mah] synonym: "sensitive to rotenone during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to rotenone during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:28201 ! rotenone relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:28201 ! rotenone created_by: midori creation_date: 2014-10-21T15:24:06Z [Term] id: FYPO:0003895 name: resistance to rotenone def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of rotenone than normal." [PomBase:mah] synonym: "resistance to rotenone during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to rotenone during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to rotenone" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:28201 ! rotenone relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:28201 ! rotenone created_by: midori creation_date: 2014-10-21T15:25:09Z [Term] id: FYPO:0003896 name: normal mitochondrial morphology def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of the mitochondrion is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: Note that an abnormal mitochondrion organization process may, but does not necessarily, result in abnormal mitochondrial morphology. synonym: "normal mitochondrial morphology during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal mitochondrial morphology during vegetative growth" EXACT [PomBase:mah] synonym: "normal mitochondrial tubular network morphology" EXACT [PMID:20655879, PomBase:al] is_a: FYPO:0001313 ! normal subcellular component during vegetative growth is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005739 ! mitochondrion intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005739 ! mitochondrion relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-10-21T15:37:07Z [Term] id: FYPO:0003897 name: mitochondrial aggregation at cell tip during cellular response to reactive oxygen species def: "An abnormal intracellular mitochondrion distribution phenotype observed in the vegetative growth phase of the life cycle in which mitochondria cluster together more than normal, with a cluster at one or both ends of the cell, during a cellular response to reactive oxygen species." [PomBase:mah] synonym: "aggregated mitochondria at cell tip during cellular response to reactive oxygen species" NARROW [PomBase:vw] synonym: "mitochondrial aggregation at cell tip during cellular response to reactive oxygen species during mitotic cell cycle" RELATED [PomBase:mah] synonym: "mitochondrial aggregation at cell tip during cellular response to reactive oxygen species during vegetative growth" EXACT [PomBase:mah] synonym: "mitochondrial aggregation at cell tip during cellular response to ROS" EXACT [GO:0034614] is_a: FYPO:0000896 ! mitochondrial aggregation at cell tip intersection_of: PATO:0001629 ! aggregated intersection_of: happens_during GO:0034614 ! cellular response to reactive oxygen species intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005739 ! mitochondrion intersection_of: occurs_at GO:0051286 ! cell tip relationship: happens_during GO:0034614 ! cellular response to reactive oxygen species relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005739 ! mitochondrion relationship: occurs_at GO:0051286 ! cell tip created_by: midori creation_date: 2014-10-21T15:51:32Z [Term] id: FYPO:0003898 name: normal growth on glycerol/ethanol carbon source def: "A vegetative cell population growth phenotype in which cells grow normally in a medium containing glycerol and ethanol as the carbon sources." [PomBase:mah] synonym: "normal cell population growth on glycerol/ethanol carbon source" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal vegetative cell population growth on glycerol/ethanol carbon source" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth created_by: midori creation_date: 2014-10-21T15:56:28Z [Term] id: FYPO:0003899 name: abnormal triphosphatase activity def: "A molecular function phenotype in which the observed rate of a triphosphatase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0050355 ! triphosphatase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0050355 ! triphosphatase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-10-21T15:58:12Z [Term] id: FYPO:0003900 name: decreased triphosphatase activity def: "A molecular function phenotype in which the observed rate of a triphosphatase activity is decreased." [PomBase:mah] synonym: "reduced triphosphatase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0003899 ! abnormal triphosphatase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0050355 ! triphosphatase activity relationship: inheres_in GO:0050355 ! triphosphatase activity created_by: midori creation_date: 2014-10-21T15:58:17Z [Term] id: FYPO:0003901 name: normal triphosphatase activity def: "A molecular function phenotype in which the observed rate of a triphosphatase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0050355 ! triphosphatase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0050355 ! triphosphatase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-10-21T15:58:37Z [Term] id: FYPO:0003902 name: resistance to etoposide def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of etoposide than normal." [PomBase:mah] synonym: "resistance to etoposide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to etoposide during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to etoposide" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:4911 ! etoposide relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:4911 ! etoposide created_by: midori creation_date: 2014-10-21T16:02:09Z [Term] id: FYPO:0003903 name: loss of viability at low temperature def: "A cell population phenotype in which a smaller than normal proportion of the population remains viable when are grown at a temperature lower than standard." [PomBase:mah] comment: For S. pombe, low temperature usually means below 25 degrees C. Use this term to annotate experiments in which a culture is grown at low temperature, and then the number of cells viable enough to form a colony upon return to standard or high temperature is measured and compared to wild type. synonym: "decreased viability at low temperature" EXACT [PomBase:mah] synonym: "loss of cell population viability at low temperature" EXACT [PomBase:mah] synonym: "loss of viability at restrictive temperature" RELATED [PomBase:mah] synonym: "reduced viability at low temperature" EXACT [PomBase:mah] is_a: FYPO:0001985 ! abnormal phenotype is_a: FYPO:0002057 ! cell population viability created_by: midori creation_date: 2014-10-22T10:30:48Z [Term] id: FYPO:0003904 name: normal plasma membrane morphology def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of the plasma membrane is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal plasma membrane morphology during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal plasma membrane morphology during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001313 ! normal subcellular component during vegetative growth is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005886 ! plasma membrane intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005886 ! plasma membrane relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-10-22T10:34:28Z [Term] id: FYPO:0003905 name: normal meiotic spindle pole body morphology during meiosis II def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of the spindle pole body is normal (i.e. indistinguishable from wild type) during the second meiotic nuclear division." [PomBase:mah] comment: Note that an abnormal spindle pole body organization process may, but does not necessarily, result in abnormal spindle pole body structure. synonym: "normal meiotic SPB morphology during meiosis II" EXACT [PomBase:mah] synonym: "normal meiotic spindle pole body structure during meiosis II" NARROW [PomBase:mah] synonym: "normal spindle pole body morphology during meiosis II" EXACT [PomBase:mah] synonym: "normal spindle pole body morphology during second meiotic nuclear division" EXACT [PomBase:mah] is_a: FYPO:0001313 ! normal subcellular component during vegetative growth is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0007135 ! meiosis II intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0035974 ! meiotic spindle pole body intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0007135 ! meiosis II relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0035974 ! meiotic spindle pole body relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-10-22T10:37:14Z [Term] id: FYPO:0003906 name: normal growth on bleomycin def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing bleomycin." [PomBase:mah] synonym: "normal cell population growth in presence of bleomycin" EXACT [PomBase:mah] synonym: "normal cell population growth on bleomycin" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to bleomycin" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on bleomycin" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:22907 ! bleomycin relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:22907 ! bleomycin created_by: midori creation_date: 2014-10-22T10:57:17Z [Term] id: FYPO:0003907 name: sensitive to okadaic acid def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to okadaic acid. Cells stop growing (and may die) at a concentration of okadaic acid that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to okadaic acid" EXACT [PomBase:mah] synonym: "sensitive to okadaic acid during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to okadaic acid during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:44658 ! okadaic acid relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:44658 ! okadaic acid created_by: midori creation_date: 2014-10-22T11:00:34Z [Term] id: FYPO:0003908 name: increased antisense RNA transcription at stress response genes def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which antisense RNA transcription occurs to a greater extent than normal at genes that are expressed in response to stress. All stress-responsive genes, or a specific subset of such genes, may be affected." [PomBase:mah] synonym: "increased antisense RNA transcription at stress response genes during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased antisense RNA transcription at stress response genes during vegetative growth" EXACT [PomBase:mah] synonym: "increased antisense transcription at stress response genes" EXACT [PomBase:mah] synonym: "increased antisense transcription at stress response genes during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002913 ! increased antisense RNA transcription created_by: midori creation_date: 2014-10-22T11:40:02Z [Term] id: FYPO:0003909 name: increased nucleosome occupancy at CRE site def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which nucleosome occupancy is greater than normal at promoters containing CRE sites. Nucleosome occupancy measures the tendency for DNA in a given region to be packaged into nucleosomes." [PMID:25122751, PomBase:mah] is_a: FYPO:0003812 ! abnormal nucleosome positioning at stress response genes created_by: midori creation_date: 2014-10-22T11:48:22Z [Term] id: FYPO:0003910 name: abolished VLP localization to nucleus during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of retrotransposon nucleocapsid complexes (also called virus-like particles, VLPs) to the nucleus is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished retrotransposon nucleocapsid localization to nucleus during vegetative growth" EXACT [GO:0000943] synonym: "abolished virus-like particle localization to nucleus during vegetative growth" EXACT [PomBase:mah] synonym: "abolished VLP localisation to nucleus during vegetative growth" EXACT [PomBase:mah] synonym: "abolished VLP localization in nucleus during vegetative growth" EXACT [PomBase:mah] synonym: "VLP localization to nucleus abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001424 ! abolished protein localization to nucleus during vegetative growth created_by: midori creation_date: 2014-10-22T13:59:34Z [Term] id: FYPO:0003911 name: UGA suppression def: "A translation phenotype in which a tRNA pairs with mRNA at the stop codon UGA, and incorporates an amino acid residue into the nascent polypeptide." [PomBase:mah] synonym: "opal suppression" EXACT [PomBase:mah] synonym: "opal suppressor" EXACT [PomBase:mah] synonym: "UGA suppressor" EXACT [PomBase:mah] is_a: FYPO:0001797 ! abnormal translation created_by: midori creation_date: 2014-10-22T14:37:43Z [Term] id: FYPO:0003912 name: decreased double-strand break repair via homologous recombination def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which double-strand break repair via homologous recombination occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased double-strand break repair via homologous recombination during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased double-strand break repair via homologous recombination during vegetative growth" EXACT [PomBase:mah] synonym: "reduced double-strand break repair via homologous recombination" EXACT [PomBase:mah] is_a: FYPO:0002340 ! decreased DNA recombination during vegetative growth is_a: FYPO:0003660 ! decreased double-strand break repair intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000724 ! double-strand break repair via homologous recombination relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000724 ! double-strand break repair via homologous recombination created_by: midori creation_date: 2014-10-22T14:54:20Z [Term] id: FYPO:0003913 name: decreased minichromosome loss during vegetative growth def: "A cell phenotype in which minichromosomes are lost at a lower frequency than normal during the vegetative growth phase of the life cycle. Minichromosome loss occurs when one or both daughter cells do not inherit copies of a minichromosome from the mother cell, and may result from failure of minichromosome replication or segregation." [PomBase:mah] comment: Note that in budding yeast, a plasmid loss phenotype is often called a minichromosome maintenance defect, because "minichromosome" is roughly synonymous with an autonomously replicated and segregated plasmid in that organism. In fission yeast, a minichromosome is a large portion of a chromosome, usually about half of chromosome 3, that replicates and segregates autonomously. For smaller autonomously replicating and segregating constructs, consider 'decreased plasmid loss' (FYPO:0001311). synonym: "decreased plasmid loss during mitotic cell cycle" EXACT [PomBase:mah] synonym: "reduced minichromosome loss during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001320 ! vegetative cell phenotype is_a: FYPO:0003037 ! abnormal cell phenotype created_by: midori creation_date: 2014-10-22T14:55:34Z [Term] id: FYPO:0003914 name: increased protein level in stationary phase def: "A cell phenotype in which the amount of protein measured in a cell is higher than normal when the population in which the cell is found is in stationary phase. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein accumulation in stationary phase" RELATED [PomBase:mah] is_a: FYPO:0000836 ! increased protein level created_by: midori creation_date: 2014-10-22T15:05:22Z [Term] id: FYPO:0003915 name: decreased mitochondrial protein level def: "A cell phenotype in which the amount of protein measured in the mitochondrion is lower than normal when the cell is in the vegetative growth phase of the life cycle. Total protein or a specific protein may be affected." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased level of mitochondrial proteins" EXACT [PomBase:al] synonym: "decreased mitochondrial protein level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased mitochondrial protein level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein level in mitochondrion during vegetative growth" EXACT [PomBase:mah] synonym: "reduced mitochondrial protein level" EXACT [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: FYPO:0001324 ! decreased protein level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005739 ! mitochondrion intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005739 ! mitochondrion relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2014-10-22T17:27:17Z [Term] id: FYPO:0003916 name: abnormal nonsense-mediated decay def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the degradation of messenger RNA (mRNA) molecules that contain nonsense mutations is abnormal." [PomBase:mah] synonym: "abnormal NMD" EXACT [PomBase:mah] synonym: "abnormal nonsense-mediated decay during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal nonsense-mediated decay during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" EXACT [GO:0000184] is_a: FYPO:0002136 ! abnormal RNA catabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-10-22T17:30:05Z [Term] id: FYPO:0003917 name: decreased nonsense-mediated decay def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the degradation of messenger RNA (mRNA) molecules that contain nonsense mutations is decreased." [PomBase:mah] synonym: "abolished nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" EXACT [GO:0000184] synonym: "decreased NMD" EXACT [PomBase:mah] synonym: "decreased nonsense-mediated decay during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased nonsense-mediated decay during vegetative growth" EXACT [PomBase:mah] synonym: "reduced nonsense-mediated decay" EXACT [PomBase:mah] is_a: FYPO:0002137 ! decreased RNA catabolic process during vegetative growth is_a: FYPO:0003916 ! abnormal nonsense-mediated decay intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay created_by: midori creation_date: 2014-10-22T17:30:30Z [Term] id: FYPO:0003918 name: abolished nonsense-mediated decay def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the degradation of messenger RNA (mRNA) molecules that contain nonsense mutations does not occur." [PomBase:mah] synonym: "abolished NMD" EXACT [PomBase:mah] synonym: "abolished nonsense-mediated decay during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished nonsense-mediated decay during vegetative growth" EXACT [PomBase:mah] synonym: "abolished nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" EXACT [GO:0000184] synonym: "nonsense-mediated decay abolished" EXACT [PomBase:mah] is_a: FYPO:0003916 ! abnormal nonsense-mediated decay is_a: FYPO:0003934 ! abolished nuclear mRNA catabolic process intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay created_by: midori creation_date: 2014-10-22T17:31:00Z [Term] id: FYPO:0003919 name: abolished protein localization to medial cortical node def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the medial cortical nodes is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to medial cortical node" EXACT [PomBase:mah] synonym: "abolished protein localization to cortical medial dot" EXACT [PomBase:mah] synonym: "abolished protein localization to cytokinetic nodes" RELATED [PomBase:mah] synonym: "abolished protein localization to medial cortical node during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to medial cortical node during vegetative growth" EXACT [PomBase:mah] synonym: "abolished protein localization to medial cortical nodes" EXACT [PomBase:mah] synonym: "protein localization to medial cortical node abolished" EXACT [PomBase:mah] is_a: FYPO:0002555 ! abolished protein localization to medial cortex during vegetative growth is_a: FYPO:0003289 ! abnormal protein localization to medial cortical node intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1902577 ! protein localization to medial cortical node relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1902577 ! protein localization to medial cortical node created_by: midori creation_date: 2014-10-23T15:16:21Z [Term] id: FYPO:0003920 name: increased replication fork arrest at mating-type locus def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which replication fork arrest at the mating-type locus occurs to a greater extent than normal." [PomBase:mah] synonym: "increased replication fork arrest at mating-type locus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased replication fork arrest at mating-type locus during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003083 ! abnormal replication fork arrest at mating-type locus is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0011000 ! replication fork arrest at mating type locus relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0011000 ! replication fork arrest at mating type locus created_by: midori creation_date: 2014-10-23T15:35:55Z [Term] id: FYPO:0003921 name: increased replication fork arrest at rDNA repeats def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which replication fork arrest at abnormal replication fork arrest at sites within the eukaryotic rDNA repeat spacer occurs to a greater extent than normal." [PomBase:mah] synonym: "increased replication fork arrest at rDNA repeats during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased replication fork arrest at rDNA repeats during vegetative growth" EXACT [PomBase:mah] synonym: "increased replication fork arrest at ribosomal DNA repeats" EXACT [PomBase:mah] is_a: FYPO:0003089 ! abnormal replication fork arrest at rDNA repeats is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0031582 ! replication fork arrest at rDNA repeats relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0031582 ! replication fork arrest at rDNA repeats created_by: midori creation_date: 2014-10-23T15:36:58Z [Term] id: FYPO:0003922 name: increased replication fork arrest at tRNA locus def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which replication fork arrest at abnormal replication fork arrest at sites within the eukaryotic tRNA transcription unit occurs to a greater extent than normal." [PomBase:mah] synonym: "increased replication fork arrest at tRNA genes" EXACT [PomBase:mah] synonym: "increased replication fork arrest at tRNA locus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased replication fork arrest at tRNA locus during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003088 ! abnormal replication fork arrest is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0090001 ! replication fork arrest at tRNA locus relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0090001 ! replication fork arrest at tRNA locus created_by: midori creation_date: 2014-10-23T15:37:50Z [Term] id: FYPO:0003923 name: decreased rate of DNA strand elongation involved in mitotic DNA replication def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the rate, or speed, of DNA strand elongation involved in mitotic DNA replication is decreased." [PomBase:mah] synonym: "decreased rate of DNA strand elongation involved in mitotic DNA replication during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased rate of DNA strand elongation involved in mitotic DNA replication during vegetative growth" EXACT [PomBase:mah] synonym: "reduced rate of DNA strand elongation involved in mitotic DNA replication during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001343 ! abnormal mitotic DNA replication is_a: FYPO:0001981 ! decreased rate of DNA replication intersection_of: PATO:0000911 ! decreased rate intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902983 ! DNA strand elongation involved in mitotic DNA replication relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902983 ! DNA strand elongation involved in mitotic DNA replication created_by: midori creation_date: 2014-10-23T15:45:04Z [Term] id: FYPO:0003924 name: increased DNA damage at stalled replication fork def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of DNA damage measured at arrested replication forks in a cell is greater than normal. The number, extent, or both of damage sites may be increased." [PomBase:mah] synonym: "increased DNA damage at arrested replication fork" EXACT [PomBase:mah] synonym: "increased DNA damage at stalled replication fork during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased DNA damage at stalled replication fork during vegetative growth" EXACT [PomBase:mah] synonym: "increased number of DNA lesions at stalled replication forks during vegetative growth" RELATED [PomBase:al] is_a: FYPO:0003547 ! increased DNA damage during vegetative growth created_by: midori creation_date: 2014-10-23T15:47:13Z [Term] id: FYPO:0003925 name: decreased rate of DNA strand elongation involved in mitotic DNA replication at highly transcribed RNA polymerase II genes def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the rate, or speed, of DNA strand elongation involved in mitotic DNA replication is decreased in regions where RNA polymerase II actively transcribes genes." [PMID:22426534, PomBase:mah] synonym: "decreased rate of DNA strand elongation at highly transcribed RNA polymerase II genes" EXACT [PomBase:mah] synonym: "decreased rate of DNA strand elongation at highly transcribed RNA polymerase II genes involved in mitotic DNA replication" EXACT [PomBase:mah] synonym: "decreased rate of DNA strand elongation at highly transcribed RNA polymerase II genes involved in mitotic DNA replication during vegetative growth" EXACT [PomBase:mah] synonym: "decreased rate of DNA strand elongation involved in mitotic DNA replication during mitotic cell cycle at highly transcribed RNA polymerase II genes" RELATED [PomBase:mah] synonym: "reduced rate of DNA strand elongation involved in mitotic DNA replication during vegetative growth at highly transcribed RNA polymerase II genes" EXACT [PomBase:mah] synonym: "slow replication fork progression through highly transcribed RNA polymerase II genes" RELATED [PomBase:mah] is_a: FYPO:0003923 ! decreased rate of DNA strand elongation involved in mitotic DNA replication created_by: midori creation_date: 2014-10-23T15:49:45Z [Term] id: FYPO:0003926 name: increased number of converged replication forks def: "A cell phenotype in which a cell contains a larger number of sites where replication forks have converged than normal. Additional converged forks are usually detected at sites that are normally replicated unidirectionally." [PMID:22426534, PomBase:mah] synonym: "increased converged forks" EXACT [PMID:22426534] synonym: "increased number of converged replication forks during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased number of converged replication forks during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003755 ! abnormal vegetative cell phenotype created_by: midori creation_date: 2014-10-28T16:14:25Z [Term] id: FYPO:0003927 name: decreased population viability in presence of persistent double-strand breaks def: "A cell population phenotype in which a smaller than normal proportion of the population is viable when double-strand breaks in DNA are continually made (for example, by constitutive expression of a nuclease)." [PMID:22093869, PomBase:mah] comment: This phenotype is commonly assayed by continuous expression of the HO endonuclease. synonym: "decreased frequency of HO survivors" NARROW [PMID:22093869] synonym: "decreased population viability in presence of nuclease" RELATED [PomBase:mah] synonym: "reduced population viability in presence of persistent double-strand breaks" EXACT [PomBase:mah] is_a: FYPO:0002057 ! cell population viability created_by: midori creation_date: 2014-10-28T16:27:07Z [Term] id: FYPO:0003928 name: altered double-strand break repair junction in presence of persistent double-strand breaks def: "A cell phenotype in which the repair of double-strand breaks in DNA that are continually made (for example, by constitutive expression of a nuclease) results in repair junctions that differ from wild type." [PMID:22093869, PomBase:mah] comment: This phenotype is commonly assayed using continuous expression of the HO endonuclease, and in mutant cells that survive constitutive DNA cleavage by HO, break repair patterns differ from those in wild type HO survivors. synonym: "abnormal double-strand break repair resulting in formation of altered repair junction" EXACT [PomBase:mah] synonym: "altered pattern of repair junctions in HO survivors" NARROW [PMID:22093869] is_a: FYPO:0000777 ! abnormal double-strand break repair created_by: midori creation_date: 2014-10-28T16:28:47Z [Term] id: FYPO:0003929 name: spores sensitive to ionizing radiation def: "A cell phenotype in which spores germinate to a lower extent than wild type following exposure to ionizing radiation." [PMID:24847916, PomBase:mah] synonym: "sensitive to ionizing radiation in the spore phase" EXACT [PMID:24847916] synonym: "spores sensitive to IR" EXACT [PomBase:mah] is_a: FYPO:0003037 ! abnormal cell phenotype created_by: midori creation_date: 2014-10-28T16:33:39Z [Term] id: FYPO:0003930 name: decreased protein level during cellular response to salt stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during a cellular response to salt stress is lower than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein accumulation during cellular response to salt stress" RELATED [PomBase:mah] synonym: "decreased protein level during cellular response to salt stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein level during cellular response to salt stress during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein level during cellular response to salt stress" EXACT [PomBase:mah] is_a: FYPO:0001324 ! decreased protein level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0071472 ! cellular response to salt stress intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0071472 ! cellular response to salt stress relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2014-10-28T16:36:52Z [Term] id: FYPO:0003931 name: inviable aseptate vegetative cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell has no septum and is inviable." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "inviable aseptate cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable aseptate cell during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000949 ! aseptate intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000949 ! aseptate relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2014-10-28T16:42:24Z [Term] id: FYPO:0003932 name: normal nuclear 5'-3' exonucleolytic mRNA catabolic process def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which an exonucleolytic RNA catabolic process that proceeds in the 5' to 3' direction to degrade mRNA encoded in the nucleus is normal (i.e. indistinguishable from wild type)." [GO:0034428, PomBase:mah] synonym: "normal 5'-3' exonucleolytic nuclear-transcribed mRNA catabolic process" EXACT [GO:0034428] synonym: "normal nuclear 5'-3' exonucleolytic mRNA catabolic process during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal nuclear 5'-3' exonucleolytic mRNA catabolic process during vegetative growth" EXACT [PomBase:mah] synonym: "normal nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3'" EXACT [GO:0034428] is_a: FYPO:0002939 ! normal nuclear mRNA catabolic process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034428 ! nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3' intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034428 ! nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3' relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-10-29T10:34:30Z [Term] id: FYPO:0003933 name: decreased nuclear 5'-3' exonucleolytic mRNA catabolic process def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of an exonucleolytic RNA catabolic process that proceeds in the 5' to 3' direction to degrade mRNA encoded in the nucleus is decreased." [GO:0034428, PomBase:mah] synonym: "decreased 5'-3' exonucleolytic nuclear-transcribed mRNA catabolic process" EXACT [GO:0034428] synonym: "decreased nuclear 5'-3' exonucleolytic mRNA catabolic process during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased nuclear 5'-3' exonucleolytic mRNA catabolic process during vegetative growth" EXACT [PomBase:mah] synonym: "decreased nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3'" EXACT [GO:0034428] synonym: "reduced nuclear 5'-3' exonucleolytic mRNA catabolic process" EXACT [PomBase:mah] is_a: FYPO:0002137 ! decreased RNA catabolic process during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034428 ! nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3' relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034428 ! nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3' created_by: midori creation_date: 2014-10-29T10:39:37Z [Term] id: FYPO:0003934 name: abolished nuclear mRNA catabolic process def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which an RNA catabolic process that degrades mRNA encoded in the nucleus does not occur. Total mRNA or a specific mRNA, such as the mRNA transcribed from a gene of interest, may be affected." [GO:0000956, PomBase:mah] synonym: "abolished nuclear mRNA breakdown" EXACT [GO:0000956] synonym: "abolished nuclear mRNA catabolic process during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished nuclear mRNA catabolic process during vegetative growth" EXACT [PomBase:mah] synonym: "abolished nuclear mRNA catabolism" EXACT [GO:0000956] synonym: "abolished nuclear mRNA degradation" EXACT [GO:0000956] synonym: "abolished nuclear-transcribed mRNA catabolic process" EXACT [GO:0000956] synonym: "nuclear mRNA catabolic process abolished" EXACT [PomBase:mah] is_a: FYPO:0001348 ! cellular metabolism phenotype during vegetative growth is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0000956 ! nuclear-transcribed mRNA catabolic process relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0000956 ! nuclear-transcribed mRNA catabolic process created_by: midori creation_date: 2014-10-29T10:42:42Z [Term] id: FYPO:0003935 name: decreased protein localization to Golgi apparatus, with protein mislocalized to endoplasmic reticulum def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the Golgi apparatus is decreased, and the protein is present in the endoplasmic reticulum instead." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to Golgi apparatus, with protein mislocalised to endoplasmic reticulum" EXACT [PomBase:mah] synonym: "decreased protein localization to Golgi apparatus, with protein mislocalized to endoplasmic reticulum during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to Golgi apparatus, with protein mislocalized to endoplasmic reticulum during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to Golgi apparatus, with protein mislocalized to endoplasmic reticulum" EXACT [PomBase:mah] is_a: FYPO:0004786 ! decreased protein localization to Golgi apparatus intersection_of: FYPO:0004786 ! decreased protein localization to Golgi apparatus intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0003657 ! protein mislocalized to endoplasmic reticulum relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0003657 ! protein mislocalized to endoplasmic reticulum created_by: midori creation_date: 2014-10-29T11:25:19Z [Term] id: FYPO:0003936 name: abnormal protein localization to Golgi apparatus def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the Golgi apparatus is abnormal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to Golgi apparatus" EXACT [PomBase:mah] synonym: "abnormal protein localization to Golgi apparatus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein localization to Golgi apparatus during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000443 ! abnormal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0034067 ! protein localization to Golgi apparatus intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0034067 ! protein localization to Golgi apparatus relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-10-29T11:26:09Z [Term] id: FYPO:0003937 name: increased cell population growth def: "A cell population phenotype in which cell population growth is increased relative to normal. Increased growth may reflect a reduced growth rate (i.e. faster growth), growth that occurs to a greater extent than normal, or both." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "fast aerobic cell population growth" NARROW [PomBase:mah] synonym: "increased aerobic cell population growth" NARROW [PomBase:mah] synonym: "increased growth" BROAD [PomBase:mah] is_a: FYPO:0000045 ! abnormal cell population growth is_a: FYPO:0002058 ! viable cell population created_by: midori creation_date: 2014-10-29T11:58:04Z [Term] id: FYPO:0003938 name: increased cell population growth during glucose limitation def: "A cell growth phenotype in which cell population growth is increased relative to normal under conditions of glucose limitation, such as in a medium that contains a low level of glucose and no other carbon source." [PomBase:mah] comment: Use this term if you have assayed growth of cells exposed to glucose limitation in culture. Note that glucose limitation differs from glucose starvation in that starvation results from complete absence of glucose, whereas limitation results from a shift from high to low glucose levels. Glucose concentrations below about 4.4 mM (0.08%) are typically regarded as limiting. synonym: "fast cell population growth during glucose limitation" NARROW [PomBase:mah] synonym: "increased cell population growth in response to glucose limitation" EXACT [PomBase:mah] synonym: "resistant to glucose limitation" RELATED [PomBase:mah] is_a: FYPO:0003937 ! increased cell population growth created_by: midori creation_date: 2014-10-29T11:58:39Z [Term] id: FYPO:0003939 name: abnormal m7G(5')pppN diphosphatase activity def: "A molecular function phenotype in which the observed rate of m7G(5')pppN diphosphatase activity is abnormal." [PomBase:mah] synonym: "abnormal mRNA decapping activity" RELATED [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0050072 ! m7G(5')pppN diphosphatase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0050072 ! m7G(5')pppN diphosphatase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-10-29T12:02:57Z [Term] id: FYPO:0003940 name: abolished m7G(5')pppN diphosphatase activity def: "A molecular function phenotype in which m7G(5')pppN diphosphatase activity is absent." [PomBase:mah] synonym: "abolished mRNA decapping activity" RELATED [PomBase:mah] synonym: "m7G(5')pppN diphosphatase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0003939 ! abnormal m7G(5')pppN diphosphatase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0050072 ! m7G(5')pppN diphosphatase activity relationship: towards GO:0050072 ! m7G(5')pppN diphosphatase activity created_by: midori creation_date: 2014-10-29T12:03:01Z [Term] id: FYPO:0003941 name: decreased m7G(5')pppN diphosphatase activity def: "A molecular function phenotype in which the observed rate of m7G(5')pppN diphosphatase activity is decreased." [PomBase:mah] synonym: "decreased mRNA decapping activity" RELATED [PomBase:mah] synonym: "reduced m7G(5')pppN diphosphatase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0003939 ! abnormal m7G(5')pppN diphosphatase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0050072 ! m7G(5')pppN diphosphatase activity relationship: inheres_in GO:0050072 ! m7G(5')pppN diphosphatase activity created_by: midori creation_date: 2014-10-29T12:03:06Z [Term] id: FYPO:0003942 name: normal m7G(5')pppN diphosphatase activity def: "A molecular function phenotype in which the observed rate of m7G(5')pppN diphosphatase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal mRNA decapping activity" RELATED [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0050072 ! m7G(5')pppN diphosphatase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0050072 ! m7G(5')pppN diphosphatase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-10-29T12:04:05Z [Term] id: FYPO:0003943 name: abnormal thioredoxin peroxidase activity def: "A molecular function phenotype in which the observed rate of thioredoxin peroxidase activity is abnormal." [PomBase:mah] is_a: FYPO:0000689 ! abnormal oxidoreductase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0008379 ! thioredoxin peroxidase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0008379 ! thioredoxin peroxidase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-10-29T12:12:01Z [Term] id: FYPO:0003944 name: increased thioredoxin peroxidase activity def: "A molecular function phenotype in which the observed rate of thioredoxin peroxidase activity is increased." [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0003943 ! abnormal thioredoxin peroxidase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0008379 ! thioredoxin peroxidase activity relationship: inheres_in GO:0008379 ! thioredoxin peroxidase activity created_by: midori creation_date: 2014-10-29T12:12:07Z [Term] id: FYPO:0003945 name: increased RNA catabolic process during cellular response to hydrogen peroxide def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of an RNA catabolic process is increased during a cellular response to hydrogen peroxide." [PomBase:mah] synonym: "increased RNA breakdown during cellular response to hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] synonym: "increased RNA catabolic process during cellular response to H2O2" RELATED [PomBase:mah] synonym: "increased RNA catabolic process during cellular response to hydrogen peroxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased RNA catabolism during cellular response to hydrogen peroxide" EXACT [GO:0006401] synonym: "increased RNA degradation during cellular response to hydrogen peroxide" EXACT [PomBase:mah] is_a: FYPO:0002138 ! increased RNA catabolic process during vegetative growth intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0070301 ! cellular response to hydrogen peroxide intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006401 ! RNA catabolic process relationship: happens_during GO:0070301 ! cellular response to hydrogen peroxide relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006401 ! RNA catabolic process created_by: midori creation_date: 2014-10-29T12:15:22Z [Term] id: FYPO:0003946 name: delayed protein localization to cell division site def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the site of cell division begins later than normal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "delayed protein localisation to cell division site" EXACT [PomBase:mah] synonym: "delayed protein localization to cell division site during mitotic cell cycle" RELATED [PomBase:mah] synonym: "delayed protein localization to cell division site during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001401 ! abnormal protein localization to cell division site is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072741 ! protein localization to cell division site relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072741 ! protein localization to cell division site created_by: midori creation_date: 2014-10-29T12:23:19Z [Term] id: FYPO:0003947 name: normal nonsense-mediated decay def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the degradation of messenger RNA (mRNA) molecules that contain nonsense mutations is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal NMD" EXACT [PomBase:mah] synonym: "normal nonsense-mediated decay during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal nonsense-mediated decay during vegetative growth" EXACT [PomBase:mah] synonym: "normal nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" EXACT [GO:0000184] is_a: FYPO:0000294 ! RNA metabolism phenotype is_a: FYPO:0002939 ! normal nuclear mRNA catabolic process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000184 ! nuclear-transcribed mRNA catabolic process, nonsense-mediated decay relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-10-29T13:19:05Z [Term] id: FYPO:0003948 name: abnormal sulfite reductase activity def: "A molecular function phenotype in which the observed rate of sulfite reductase activity is abnormal." [PomBase:mah] synonym: "abnormal sulphite reductase activity" EXACT [PomBase:mah] is_a: FYPO:0000689 ! abnormal oxidoreductase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0016002 ! sulfite reductase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0016002 ! sulfite reductase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-10-29T13:29:08Z [Term] id: FYPO:0003949 name: decreased sulfite reductase activity def: "A molecular function phenotype in which the observed rate of sulfite reductase activity is decreased." [PomBase:mah] synonym: "decreased sulphite reductase activity" EXACT [PomBase:mah] synonym: "reduced sulfite reductase activity" EXACT [PomBase:mah] is_a: FYPO:0000690 ! decreased oxidoreductase activity is_a: FYPO:0003948 ! abnormal sulfite reductase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0016002 ! sulfite reductase activity relationship: inheres_in GO:0016002 ! sulfite reductase activity created_by: midori creation_date: 2014-10-29T13:29:13Z [Term] id: FYPO:0003950 name: decreased protein localization to chromatin at replication origin def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to chromatin at replication origins is decreased." [PMID:12925774, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to chromatin at replication origin" EXACT [PomBase:mah] synonym: "decreased protein localization to chromatin at replication origins during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to chromatin at replication origins during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to chromatin at replication origin" EXACT [PomBase:mah] is_a: FYPO:0002909 ! decreased protein localization to chromatin during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071168 ! protein localization to chromatin intersection_of: occurs_at SO:0000296 ! origin_of_replication relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071168 ! protein localization to chromatin relationship: occurs_at SO:0000296 ! origin_of_replication created_by: midori creation_date: 2014-10-29T13:34:10Z [Term] id: FYPO:0003951 name: increased protein tyrosine phosphorylation during cellular response to heat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of tyrosine residues in one or more specific proteins, or of specific protein sites, occurs to a greater extent than normal during a cellular response to heat." [PomBase:mah] synonym: "increased peptidyl-tyrosine phosphorylation during cellular response to heat" EXACT [GO:0018108, PomBase:mah] synonym: "increased protein tyrosine phosphorylation during cellular response to heat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein tyrosine phosphorylation during cellular response to heat during vegetative growth" EXACT [PomBase:mah] synonym: "increased tyrosine phosphorylation during cellular response to heat" EXACT [PomBase:al] is_a: FYPO:0001180 ! increased protein tyrosine phosphorylation is_a: FYPO:0002129 ! increased protein phosphorylation during cellular response to heat intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0034605 ! cellular response to heat intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0018108 ! peptidyl-tyrosine phosphorylation relationship: happens_during GO:0034605 ! cellular response to heat relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0018108 ! peptidyl-tyrosine phosphorylation created_by: midori creation_date: 2014-10-29T13:36:45Z [Term] id: FYPO:0003952 name: delayed protein phosphorylation during cellular response to oxidative stress def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, begins later than normal during a cellular response to oxidative stress." [PomBase:mah] synonym: "delayed protein phosphorylation during cellular response to oxidative stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "delayed protein phosphorylation during cellular response to oxidative stress during vegetative growth" EXACT [PomBase:mah] synonym: "delayed protein/peptide phosphorylation during cellular response to oxidative stress" EXACT [PomBase:mah] is_a: FYPO:0002830 ! delayed protein phosphorylation during vegetative growth intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0034599 ! cellular response to oxidative stress intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0034599 ! cellular response to oxidative stress relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2014-10-29T13:38:00Z [Term] id: FYPO:0003953 name: abnormal triglyceride biosynthetic process def: "A metabolism phenotype observed in the vegetative growth phase of the life cycle in which triglyceride biosynthesis is abnormal." [PomBase:mah] synonym: "abnormal TAG biosynthetic process" EXACT [PomBase:mah] synonym: "abnormal triacylglycerol biosynthesis" EXACT [GO:0019432] synonym: "abnormal triacylglycerol biosynthetic process" EXACT [PomBase:mah] synonym: "abnormal triglyceride biosynthesis" EXACT [PomBase:mah] synonym: "abnormal triglyceride biosynthetic process during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal triglyceride biosynthetic process during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001363 ! abnormal metabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0019432 ! triglyceride biosynthetic process intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0019432 ! triglyceride biosynthetic process relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-10-29T13:51:09Z [Term] id: FYPO:0003954 name: decreased triglyceride biosynthetic process def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which triglyceride biosynthesis is decreased." [GO:0019493, PomBase:mah] synonym: "decreased TAG biosynthetic process" EXACT [PomBase:mah] synonym: "decreased triacylglycerol biosynthesis" EXACT [GO:0019432] synonym: "decreased triacylglycerol biosynthetic process" EXACT [PomBase:mah] synonym: "decreased triglyceride biosynthesis" EXACT [PomBase:mah] synonym: "decreased triglyceride biosynthetic process during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased triglyceride biosynthetic process during vegetative growth" EXACT [PomBase:mah] synonym: "reduced triglyceride biosynthetic process" EXACT [PomBase:mah] is_a: FYPO:0001348 ! cellular metabolism phenotype during vegetative growth is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0019432 ! triglyceride biosynthetic process relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0019432 ! triglyceride biosynthetic process created_by: midori creation_date: 2014-10-29T13:52:23Z [Term] id: FYPO:0003955 name: increased triglyceride biosynthetic process def: "A cellular metabolism phenotype observed in the vegetative growth phase of the life cycle in which triglyceride biosynthesis is increased." [PomBase:mah] synonym: "increased TAG biosynthetic process" EXACT [PomBase:mah] synonym: "increased triacylglycerol biosynthesis" EXACT [GO:0019432] synonym: "increased triacylglycerol biosynthetic process" EXACT [PomBase:mah] synonym: "increased triglyceride biosynthesis" EXACT [GO:0019432] synonym: "increased triglyceride biosynthetic process during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased triglyceride biosynthetic process during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001348 ! cellular metabolism phenotype during vegetative growth is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0019432 ! triglyceride biosynthetic process relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0019432 ! triglyceride biosynthetic process created_by: midori creation_date: 2014-10-29T13:54:00Z [Term] id: FYPO:0003956 name: UAA suppression def: "A translation phenotype in which a tRNA pairs with mRNA at the stop codon UAA, and incorporates an amino acid residue into the nascent polypeptide." [PomBase:mah] synonym: "ochre suppression" EXACT [PomBase:mah] synonym: "ochre suppressor" EXACT [PomBase:mah] synonym: "UAA suppressor" EXACT [PomBase:mah] is_a: FYPO:0001797 ! abnormal translation created_by: midori creation_date: 2014-10-29T14:18:36Z [Term] id: FYPO:0003957 name: abolished tRNA N2-guanine methylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the posttranscriptional addition of methyl groups to the N2 position of a guanine residue in a tRNA molecule is abolished. Normally, two methyl groups are transferred to the G26 residue." [PMID:10611485, PomBase:mah] synonym: "abolished tRNA methylation at N2 on G26" EXACT [PomBase:mah] synonym: "abolished tRNA N2-guanine dimethylation" EXACT [PMID:10611485, PomBase:mah] synonym: "abolished tRNA N2-guanine methylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished tRNA N2-guanine methylation during vegetative growth" EXACT [PomBase:mah] synonym: "tRNA N2-guanine methylation abolished" EXACT [PomBase:mah] is_a: FYPO:0000371 ! abolished RNA modification is_a: FYPO:0001766 ! abnormal tRNA methylation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0002940 ! tRNA N2-guanine methylation relationship: towards GO:0002940 ! tRNA N2-guanine methylation created_by: midori creation_date: 2014-10-29T14:49:53Z [Term] id: FYPO:0003958 name: abnormal diacylglycerol O-acyltransferase activity def: "A molecular function phenotype in which the observed rate of diacylglycerol O-acyltransferase activity is abnormal." [PomBase:mah] synonym: "abnormal DGAT activity" EXACT [PMID:12963726] synonym: "abnormal diacylglycerol acyltransferase activity" BROAD [PomBase:al] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004144 ! diacylglycerol O-acyltransferase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004144 ! diacylglycerol O-acyltransferase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-11-04T11:16:20Z [Term] id: FYPO:0003959 name: decreased diacylglycerol O-acyltransferase activity def: "A molecular function phenotype in which the observed rate of diacylglycerol O-acyltransferase activity is decreased." [PomBase:mah] synonym: "decreased DGAT activity" EXACT [PMID:12963726] synonym: "decreased diacylglycerol acyltransferase activity" BROAD [PomBase:al] synonym: "reduced diacylglycerol O-acyltransferase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0003958 ! abnormal diacylglycerol O-acyltransferase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004144 ! diacylglycerol O-acyltransferase activity relationship: inheres_in GO:0004144 ! diacylglycerol O-acyltransferase activity created_by: midori creation_date: 2014-11-04T11:16:25Z [Term] id: FYPO:0003960 name: increased diacylglycerol O-acyltransferase activity def: "A molecular function phenotype in which the observed rate of diacylglycerol O-acyltransferase activity is increased." [PomBase:mah] synonym: "increased DGAT activity" EXACT [PMID:12963726] synonym: "increased diacylglycerol acyltransferase activity" BROAD [PomBase:al] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0003958 ! abnormal diacylglycerol O-acyltransferase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0004144 ! diacylglycerol O-acyltransferase activity relationship: inheres_in GO:0004144 ! diacylglycerol O-acyltransferase activity created_by: midori creation_date: 2014-11-04T11:16:39Z [Term] id: FYPO:0003961 name: abnormal phospholipid:diacylglycerol acyltransferase activity def: "A molecular function phenotype in which the observed rate of phospholipid:diacylglycerol acyltransferase activity is abnormal." [PomBase:mah] synonym: "abnormal PDAT activity" EXACT [PMID:12963726] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0046027 ! phospholipid:diacylglycerol acyltransferase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0046027 ! phospholipid:diacylglycerol acyltransferase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-11-04T11:25:15Z [Term] id: FYPO:0003962 name: decreased phospholipid:diacylglycerol acyltransferase activity def: "A molecular function phenotype in which the observed rate of phospholipid:diacylglycerol acyltransferase activity is decreased." [PomBase:mah] synonym: "decreased PDAT activity" EXACT [PMID:12963726] synonym: "reduced phospholipid:diacylglycerol acyltransferase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0003961 ! abnormal phospholipid:diacylglycerol acyltransferase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0046027 ! phospholipid:diacylglycerol acyltransferase activity relationship: inheres_in GO:0046027 ! phospholipid:diacylglycerol acyltransferase activity created_by: midori creation_date: 2014-11-04T11:25:26Z [Term] id: FYPO:0003963 name: abnormal glutathione disulfide oxidoreductase activity def: "A molecular function phenotype in which the observed rate of a glutathione disulfide oxidoreductase activity is abnormal." [PomBase:mah] is_a: FYPO:0000689 ! abnormal oxidoreductase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0015038 ! glutathione disulfide oxidoreductase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0015038 ! glutathione disulfide oxidoreductase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-11-04T11:33:14Z [Term] id: FYPO:0003964 name: decreased glutathione disulfide oxidoreductase activity def: "A molecular function phenotype in which the observed rate of a glutathione disulfide oxidoreductase activity is decreased." [PomBase:mah] synonym: "reduced glutathione disulfide oxidoreductase activity" EXACT [PomBase:mah] is_a: FYPO:0000690 ! decreased oxidoreductase activity is_a: FYPO:0003963 ! abnormal glutathione disulfide oxidoreductase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0015038 ! glutathione disulfide oxidoreductase activity relationship: inheres_in GO:0015038 ! glutathione disulfide oxidoreductase activity created_by: midori creation_date: 2014-11-04T11:33:20Z [Term] id: FYPO:0003965 name: increased glutathione disulfide oxidoreductase activity def: "A molecular function phenotype in which the observed rate of a glutathione disulfide oxidoreductase activity is increased." [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0003963 ! abnormal glutathione disulfide oxidoreductase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0015038 ! glutathione disulfide oxidoreductase activity relationship: inheres_in GO:0015038 ! glutathione disulfide oxidoreductase activity created_by: midori creation_date: 2014-11-04T11:33:24Z [Term] id: FYPO:0003966 name: increased protein level during cellular response to salt stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during a cellular response to salt stress is higher than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein accumulation during cellular response to salt stress" RELATED [PomBase:mah] synonym: "increased protein level during cellular response to salt stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein level during cellular response to salt stress during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001327 ! increased protein level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0071472 ! cellular response to salt stress intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0071472 ! cellular response to salt stress relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2014-11-04T11:35:36Z [Term] id: FYPO:0003967 name: decreased protein level in stationary phase def: "A cell phenotype in which the amount of protein measured in a cell is lover than normal when the population in which the cell is found is in stationary phase. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein accumulation in stationary phase" RELATED [PomBase:mah] synonym: "reduced protein level in stationary phase" EXACT [PomBase:mah] is_a: FYPO:0000835 ! decreased protein level created_by: midori creation_date: 2014-11-04T11:37:03Z [Term] id: FYPO:0003968 name: inviable after spore germination, without cell division, with swollen elongated germ tube and bidirectional cell growth from spore body def: "A phenotype in which a spore germinates to produce an elongated germ tube that has a larger diameter and volume than normal, then initiates growth from the opposite end of the spore body, and does not go on to form a viable dividing cell. The cell may undergo one or two rounds of nuclear division, but does not undergo cytokinesis." [PMID:9105045, PomBase:mah, PomBase:vw] synonym: "inviable after spore germination, without cell division, with swollen elongated cell and bidirectional cell growth from spore body" EXACT [PomBase:mah] is_a: FYPO:0002911 ! inviable after spore germination, without cell division, with swollen elongated germ tube created_by: midori creation_date: 2014-11-04T11:48:40Z [Term] id: FYPO:0003969 name: mislocalized mitotic spindle def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which a cell forms a mitotic spindle in an abnormal location. The normal location is centered at the midpoint of, and parallel to, the long axis of the cell." [PomBase:mah] synonym: "mislocalised mitotic spindle" EXACT [PomBase:mah] synonym: "mislocalized mitotic spindle during vegetative growth" EXACT [PomBase:mah] synonym: "mislocalized spindle during mitosis" EXACT [PomBase:mah] is_a: FYPO:0000338 ! abnormal mitotic spindle is_a: PATO:0000628 ! mislocalised intersection_of: PATO:0000628 ! mislocalised intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0072686 ! mitotic spindle relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0072686 ! mitotic spindle created_by: midori creation_date: 2014-11-04T11:54:49Z [Term] id: FYPO:0003970 name: incomplete mitotic sister chromatid segregation, with chromatin bridge def: "A cellular process phenotype in which mitotic sister chromatid segregation stops before completing separation of chromosomes, and partially separated DNA masses are connected by one or more bridges formed of chromatin." [PMID:12455694, PomBase:mah] synonym: "incomplete mitotic sister chromatid segregation, with chromatin bridge, during vegetative growth" EXACT [PomBase:mah] synonym: "incomplete mitotic sister chromatid separation, with chromatin bridge" RELATED [PomBase:mah] is_a: FYPO:0003757 ! incomplete mitotic sister chromatid segregation created_by: midori creation_date: 2014-11-04T11:57:19Z [Term] id: FYPO:0003971 name: inviable after spore germination, multiple cell divisions, with abnormal cytokinetic cell separation and increased septum thickness def: "A phenotype in which a spore germinates to produce a cell of that undergoes two or more rounds of cell division in which cells do not completely separate upon cytokinesis, form septa that are thicker than normal, and then die." [PMID:9046095, PomBase:mah, PomBase:vw] synonym: "essential; germinating spore, multiple cell divisions, with abnormal cytokinetic cell separation and increased septum thickness" RELATED [PomBase:mah] synonym: "inviable after spore germination, multiple cell divisions, with abnormal cytokinetic cell separation and thick septa" EXACT [PomBase:mah] synonym: "inviable following spore germination, multiple cell divisions, with abnormal cytokinetic cell separation and increased septum thickness" EXACT [PomBase:mah] synonym: "inviable germinated spore, multiple cell divisions, with abnormal cytokinetic cell separation and increased septum thickness" EXACT [PomBase:mah] is_a: FYPO:0002430 ! inviable after spore germination, multiple cell divisions relationship: has_part FYPO:0001406 ! increased septum thickness relationship: has_part FYPO:0001972 ! abnormal cell separation after cytokinesis resulting in septated cell created_by: midori creation_date: 2014-11-04T12:16:20Z [Term] id: FYPO:0003972 name: abnormal exit from mitosis def: "A cellular process phenotype in which exit from mitosis is abnormal." [PomBase:mah] synonym: "abnormal exit from mitosis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal exit from mitosis during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal mitotic exit" EXACT [GO:0010458] is_a: FYPO:0000186 ! abnormal cell division is_a: FYPO:0002737 ! abnormal mitotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0010458 ! exit from mitosis intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0010458 ! exit from mitosis relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-11-04T15:32:11Z [Term] id: FYPO:0003973 name: abnormal nuclear pore distribution def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the spatial arrangement of nuclear pores within the nuclear envelope is abnormal." [PomBase:mah] synonym: "abnormal nuclear pore distribution during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal nuclear pore distribution during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000443 ! abnormal protein localization during vegetative growth is_a: FYPO:0000810 ! abnormal nucleus organization is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: FYPO:0001440 ! abnormal protein complex localization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0031081 ! nuclear pore distribution intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0031081 ! nuclear pore distribution relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-11-04T15:34:07Z [Term] id: FYPO:0003974 name: nuclear pore aggregation in cytoplasm def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which one or more clusters of nuclear pores, associated with membrane fragments derived from the nuclear envelope, are present in the cytoplasm." [PMID:7877997, PomBase:mah] synonym: "aggregated nuclear pores present in cytoplasm" EXACT [PomBase:mah] is_a: FYPO:0003973 ! abnormal nuclear pore distribution created_by: midori creation_date: 2014-11-04T15:39:11Z [Term] id: FYPO:0003975 name: fragmented nuclear envelope def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the nuclear envelope is broken into multiple small fragments, none of which completely surrounds the contents of the nucleus." [PMID:7877997, PomBase:mah] synonym: "disrupted nuclear envelope" RELATED [PomBase:mah] synonym: "disrupted nuclear membrane" RELATED [PomBase:mah] synonym: "fragmented nuclear envelope during mitotic cell cycle" RELATED [PomBase:mah] synonym: "fragmented nuclear envelope during vegetative growth" EXACT [PomBase:mah] synonym: "fragmented nuclear membrane" RELATED [PomBase:mah] is_a: FYPO:0000769 ! abnormal nuclear envelope morphology during vegetative growth is_a: FYPO:0001919 ! fragmented nucleus intersection_of: PATO:0001444 ! broken intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005635 ! nuclear envelope relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005635 ! nuclear envelope created_by: midori creation_date: 2014-11-04T15:44:30Z [Term] id: FYPO:0003976 name: inviable vegetative cell with fragmented nuclear envelope during mitotic telophase def: "A cell morphology phenotype in which a vegetatively growing cell is inviable, and has a nuclear envelope that is broken into multiple small fragments during mitotic telophase." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "inviable cell with fragmented nuclear envelope during mitotic telophase during vegetative growth" EXACT [PomBase:mah] synonym: "inviable vegetative cell with fragmented nuclear envelope during telophase of mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0000093 ! mitotic telophase intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0003975 ! fragmented nuclear envelope relationship: exists_during GO:0000093 ! mitotic telophase relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0003975 ! fragmented nuclear envelope created_by: midori creation_date: 2014-11-04T15:54:07Z [Term] id: FYPO:0003977 name: inviable vegetative cell with nuclear pore aggregation in cytoplasm during mitotic telophase def: "A cell morphology phenotype in which a vegetatively growing cell is inviable, and one or more clusters of nuclear pores are present in the cytoplasm during mitotic telophase." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "inviable cell with nuclear pore aggregation in cytoplasm during mitotic telophase during vegetative growth" EXACT [PomBase:mah] synonym: "inviable vegetative cell with aggregated nuclear pores in cytoplasm during mitotic telophase" RELATED [PomBase:mah] synonym: "inviable vegetative cell with nuclear pore aggregation in cytoplasm during telophase of mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0000093 ! mitotic telophase intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0003974 ! nuclear pore aggregation in cytoplasm relationship: exists_during GO:0000093 ! mitotic telophase relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0003974 ! nuclear pore aggregation in cytoplasm created_by: midori creation_date: 2014-11-04T15:56:47Z [Term] id: FYPO:0003978 name: inviable vegetative cell with fragmented nuclear envelope and nuclear pore aggregation in cytoplasm during mitotic telophase def: "A cell morphology phenotype in which a vegetatively growing cell is inviable, and has a nuclear envelope that is broken into multiple small fragments and one or more clusters of nuclear pores present in the cytoplasm during mitotic telophase." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "inviable cell with fragmented nuclear envelope and nuclear pore aggregation in cytoplasm during mitotic telophase during vegetative growth" EXACT [PomBase:mah] synonym: "inviable vegetative cell with fragmented nuclear envelope and nuclear pore aggregation in cytoplasm during telophase of mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0003976 ! inviable vegetative cell with fragmented nuclear envelope during mitotic telophase is_a: FYPO:0003977 ! inviable vegetative cell with nuclear pore aggregation in cytoplasm during mitotic telophase intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0000093 ! mitotic telophase intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0003974 ! nuclear pore aggregation in cytoplasm intersection_of: has_part FYPO:0003975 ! fragmented nuclear envelope relationship: exists_during GO:0000093 ! mitotic telophase relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0003974 ! nuclear pore aggregation in cytoplasm relationship: has_part FYPO:0003975 ! fragmented nuclear envelope created_by: midori creation_date: 2014-11-04T15:58:32Z [Term] id: FYPO:0003979 name: abnormal mitotic cell cycle arrest with condensed chromosomes, septated cell with 1C DNA content per nucleus def: "A cellular process phenotype in which progression through the mitotic cell cycle is arrested when cells have condensed chromosomes, a single, normally located septum, and 1C DNA content in each nucleus, under conditions where arrest does not normally occur." [PMID:8313905, PomBase:mah, PomBase:vw] comment: This phenotype arises when a cell fails to exit mitosis correctly, such that chromosomes remain condensed and cytokinesis is not completed. In wild-type cells, chromosomes are condensed only in M phase. This term can be used for mutants in which chromosomes are condensed but other normal features of M phase cells are not observed. synonym: "abnormal mitotic cell cycle arrest with condensed chromosomes, septated cell with 1C DNA content per nucleus during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal mitotic cell cycle arrest with condensed chromosomes, septated cell with 1C nuclei" EXACT [PomBase:mah] is_a: FYPO:0004719 ! abnormal mitotic cell cycle arrest with condensed chromosomes, septated cell relationship: output_of FYPO:0003972 ! abnormal exit from mitosis created_by: midori creation_date: 2014-11-04T16:04:34Z [Term] id: FYPO:0003980 name: abnormal glutathione transferase activity def: "A molecular function phenotype in which the observed rate of glutathione transferase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004364 ! glutathione transferase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004364 ! glutathione transferase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-11-04T16:13:56Z [Term] id: FYPO:0003981 name: increased glutathione transferase activity def: "A molecular function phenotype in which the observed rate of glutathione transferase activity is increased." [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0003980 ! abnormal glutathione transferase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0004364 ! glutathione transferase activity relationship: inheres_in GO:0004364 ! glutathione transferase activity created_by: midori creation_date: 2014-11-04T16:14:03Z [Term] id: FYPO:0003982 name: abnormal disulfide oxidoreductase activity def: "A molecular function phenotype in which the observed rate of disulfide oxidoreductase activity is abnormal." [PomBase:mah] is_a: FYPO:0000689 ! abnormal oxidoreductase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0015035 ! protein disulfide oxidoreductase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0015035 ! protein disulfide oxidoreductase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-11-04T16:15:59Z [Term] id: FYPO:0003983 name: increased disulfide oxidoreductase activity def: "A molecular function phenotype in which the observed rate of disulfide oxidoreductase activity is increased." [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0003982 ! abnormal disulfide oxidoreductase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0015035 ! protein disulfide oxidoreductase activity relationship: inheres_in GO:0015035 ! protein disulfide oxidoreductase activity created_by: midori creation_date: 2014-11-04T16:16:04Z [Term] id: FYPO:0003984 name: altered cellular amino acid level during vegetative growth def: "A cell phenotype in which the amount of an amino acid measured in a cell differs from normal when the cell is in the vegetative growth phase of the life cycle." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "abnormal cellular amino acid level during vegetative growth" EXACT [PomBase:mah] synonym: "altered cellular amino acid level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "altered level of amino acid in cell" EXACT [PomBase:mah] is_a: FYPO:0001323 ! altered level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:33709 ! amino acid relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:33709 ! amino acid created_by: midori creation_date: 2014-11-04T16:21:46Z [Term] id: FYPO:0003985 name: decreased cellular amino acid level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of an amino acid measured in the cell is lower than normal." [PomBase:mah] synonym: "decreased cellular amino acid level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular amino acid level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased level of amino acid in cell" EXACT [PomBase:mah] synonym: "reduced cellular amino acid level" EXACT [PomBase:mah] synonym: "reduced level of amino acid in cell" EXACT [PomBase:mah] is_a: FYPO:0001329 ! decreased level of substance in cell during vegetative growth is_a: FYPO:0003984 ! altered cellular amino acid level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33709 ! amino acid relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33709 ! amino acid created_by: midori creation_date: 2014-11-04T16:23:35Z [Term] id: FYPO:0003986 name: increased cellular amino acid level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of an amino acid measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular amino acid level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular amino acid level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth is_a: FYPO:0003984 ! altered cellular amino acid level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33709 ! amino acid relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33709 ! amino acid created_by: midori creation_date: 2014-11-04T16:24:49Z [Term] id: FYPO:0003987 name: abnormal actin cortical patch def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the amount, distribution, or morphology of actin cortical patches is abnormal." [PomBase:mah] synonym: "abnormal actin cortical patch during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal actin cortical patch during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal actin cortical patches" EXACT [PomBase:mah] is_a: FYPO:0002398 ! abnormal actin cytoskeleton during vegetative growth intersection_of: PATO:0001241 ! physical object quality intersection_of: inheres_in GO:0030479 ! actin cortical patch intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0030479 ! actin cortical patch relationship: output_of FYPO:0000790 ! abnormal actin cortical patch organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-11-05T10:41:05Z [Term] id: FYPO:0003988 name: mislocalized actin cortical patches def: "A physical cellular phenotype in which a cell has actin cortical patches in one or more abnormal locations." [PomBase:mah] synonym: "abnormal actin cortical patch location" EXACT [PomBase:mah] synonym: "abnormal actin cortical patch position" EXACT [PomBase:mah] synonym: "mislocalised actin cortical patches" EXACT [PomBase:mah] is_a: FYPO:0000136 ! cellular physical quality phenotype is_a: PATO:0000628 ! mislocalised intersection_of: PATO:0000628 ! mislocalised intersection_of: inheres_in GO:0030479 ! actin cortical patch relationship: inheres_in GO:0030479 ! actin cortical patch relationship: output_of FYPO:0000190 ! abnormal actin cortical patch localization created_by: midori creation_date: 2014-11-05T10:53:55Z [Term] id: FYPO:0003989 name: inviable stubby mononucleate vegetative cell def: "A cell morphology phenotype in which a vegetatively growing cell is inviable and has one nucleus, and the cell diameter is larger than normal and the cell length is shorter than normal." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "essential; stubby mononucleate vegetative cell" RELATED [PomBase:mah] synonym: "inviable stubby mononucleate cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable stubby mononucleate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable watermelon-shaped mononucleate vegetative cell" EXACT [PomBase:mah] synonym: "stubby mononucleate inviable vegetative cell" EXACT [PomBase:mah] is_a: FYPO:0002107 ! inviable stubby vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000024 ! stubby cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0002731 ! mononucleate relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000024 ! stubby cell relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0002731 ! mononucleate created_by: midori creation_date: 2014-11-05T11:44:54Z [Term] id: FYPO:0003990 name: sensitive to DNA damage during mitotic S phase def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to DNA damage during S phase of the mitotic cell cycle." [PMID:15643072, PomBase:mah] comment: Use this term if you have assayed growth of cells exposed to DNA damage in culture. If you have assayed the response to DNA damage at the subcellular or molecular level, consider annotating to 'abnormal cellular response to DNA damage stimulus' (FYPO:0000157). Also consider specific phenotype terms for sensitivity to substances or other stimuli that can damage DNA, e.g. 'sensitive to DNA damaging agents' (FYPO:0000266), 'sensitive to methyl methanesulfonate' (FYPO:0000089), 'sensitive to UV' (FYPO:0000268), etc. synonym: "hypersensitive to DNA damage during mitotic S phase" EXACT [PomBase:mah] synonym: "sensitive to DNA damage during mitotic S phase during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to DNA damage during S phase of mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000265 ! sensitive to DNA damage created_by: midori creation_date: 2014-11-05T14:33:34Z [Term] id: FYPO:0003991 name: increased RNA level in stationary phase def: "A cell phenotype in which the amount of RNA measured in a cell is higher than normal when the population in which the cell is found is in stationary phase. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased RNA accumulation in stationary phase" RELATED [PomBase:mah] is_a: FYPO:0001890 ! increased RNA level created_by: midori creation_date: 2014-11-05T15:01:20Z [Term] id: FYPO:0003992 name: normal RNA level during cellular response to menadione def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to menadione is normal (i.e. indistinguishable from wild type). Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [PomBase:mah] comment: We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "normal mRNA level during cellular response to menadione" NARROW [PomBase:mah] synonym: "normal RNA accumulation during cellular response to menadione" RELATED [PomBase:mah] synonym: "normal RNA level during cellular response to menadione during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal RNA level during cellular response to menadione during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001317 ! normal RNA level during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0036245 ! cellular response to menadione intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0036245 ! cellular response to menadione relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-11-05T15:02:45Z [Term] id: FYPO:0003993 name: decreased RNA level during cellular response to menadione def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to menadione is lower than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased RNA accumulation during cellular response to menadione" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to menadione during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to menadione during vegetative growth" EXACT [PomBase:mah] synonym: "decreased transcript level during cellular response to menadione" EXACT [PomBase:vw] synonym: "reduced RNA level during cellular response to menadione" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0036245 ! cellular response to menadione intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0036245 ! cellular response to menadione relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-11-05T15:33:14Z [Term] id: FYPO:0003994 name: normal succinate dehydrogenase activity def: "A molecular function phenotype in which the observed rate of succinate dehydrogenase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0000104 ! succinate dehydrogenase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0000104 ! succinate dehydrogenase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-11-05T15:36:33Z [Term] id: FYPO:0003995 name: abnormal DNA primase activity def: "A molecular function phenotype in which the observed rate of DNA primase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0003896 ! DNA primase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0003896 ! DNA primase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-11-12T13:06:54Z [Term] id: FYPO:0003996 name: abolished DNA primase activity def: "A molecular function phenotype in which DNA primase activity is absent." [PomBase:mah] synonym: "DNA primase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0003995 ! abnormal DNA primase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0003896 ! DNA primase activity relationship: towards GO:0003896 ! DNA primase activity created_by: midori creation_date: 2014-11-12T13:07:02Z [Term] id: FYPO:0003997 name: decreased DNA primase activity def: "A molecular function phenotype in which the observed rate of DNA primase activity is decreased." [PomBase:mah] synonym: "reduced DNA primase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0003995 ! abnormal DNA primase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0003896 ! DNA primase activity relationship: inheres_in GO:0003896 ! DNA primase activity created_by: midori creation_date: 2014-11-12T13:07:12Z [Term] id: FYPO:0003998 name: increased DNA primase activity def: "A molecular function phenotype in which the observed rate of DNA primase activity is increased." [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0003995 ! abnormal DNA primase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0003896 ! DNA primase activity relationship: inheres_in GO:0003896 ! DNA primase activity created_by: midori creation_date: 2014-11-12T13:07:16Z [Term] id: FYPO:0003999 name: increased glutathione synthase activity def: "A molecular function phenotype in which the observed rate of glutathione synthase activity is increased." [PomBase:mah] synonym: "increased glutathione synthetase activity" EXACT [GO:0004363] synonym: "increased GSH synthase activity" EXACT [GO:0004363] synonym: "increased phosphoribosylformylglycinamidine cyclo-ligase activity" EXACT [GO:0004363] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0002856 ! abnormal glutathione synthase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0004363 ! glutathione synthase activity relationship: inheres_in GO:0004363 ! glutathione synthase activity created_by: midori creation_date: 2014-11-12T13:19:40Z [Term] id: FYPO:0004000 name: increased glutamate-cysteine ligase activity def: "A molecular function phenotype in which the observed rate of glutamate-cysteine ligase activity is increased." [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0002853 ! abnormal glutamate-cysteine ligase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0004357 ! glutamate-cysteine ligase activity relationship: inheres_in GO:0004357 ! glutamate-cysteine ligase activity created_by: midori creation_date: 2014-11-12T13:22:27Z [Term] id: FYPO:0004001 name: normal cellular glutathione level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of glutathione (GSH) measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular glutathione level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cellular glutathione level during vegetative growth" EXACT [PomBase:mah] synonym: "normal cellular GSH level" EXACT [CHEBI:16856, PomBase:al] synonym: "normal cellular L-gamma-glutamyl-L-cysteinylglycine level" EXACT [CHEBI:16856] synonym: "normal cellular reduced glutathione level" EXACT [CHEBI:16856, PomBase:al] synonym: "normal glutathione accumulation" RELATED [PomBase:mah] is_a: FYPO:0001544 ! normal cellular sulfur level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:16856 ! glutathione relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:16856 ! glutathione created_by: midori creation_date: 2014-11-12T13:23:46Z [Term] id: FYPO:0004002 name: increased duration of protein phosphorylation during cellular response to hydroxyurea def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the duration of protein phosphorylation is increased during a cellular response to hydroxyurea. All phosphorylation may be affected, or only phosphorylation of specific proteins, or even specific sites within specific proteins." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased duration of protein phosphorylation during cellular response to HU" EXACT [PomBase:mah] synonym: "increased duration of protein phosphorylation during cellular response to hydroxyurea during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased duration of protein phosphorylation during cellular response to hydroxyurea during vegetative growth" EXACT [PomBase:mah] synonym: "prolonged protein phosphorylation during cellular response to hydroxyurea" EXACT [PomBase:mah] is_a: FYPO:0000548 ! increased duration of protein modification intersection_of: PATO:0000498 ! increased duration intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: happens_during GO:0072711 ! cellular response to hydroxyurea intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: happens_during GO:0072711 ! cellular response to hydroxyurea relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2014-11-12T13:32:38Z [Term] id: FYPO:0004003 name: delayed replication fork processing def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which replication fork processing begins later than normal. Replication fork processing is process in which a DNA replication fork that has stalled (due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes) is repaired and replication is restarted." [GO:0031297, PomBase:mah] synonym: "delayed collapsed replication fork processing" EXACT [GO:0031297] synonym: "delayed recovery from replication fork arrest" EXACT [GO:0031297] synonym: "delayed recovery from replication fork stalling" EXACT [GO:0031297] synonym: "delayed replication fork processing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "delayed replication fork processing during vegetative growth" EXACT [PomBase:mah] synonym: "delayed replication fork restart" RELATED [GO:0031297] synonym: "delayed replication restart" RELATED [GO:0031297] is_a: FYPO:0003586 ! abnormal replication fork processing is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0031297 ! replication fork processing relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0031297 ! replication fork processing created_by: midori creation_date: 2014-11-12T13:37:22Z [Term] id: FYPO:0004004 name: normal pre-replicative complex assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which pre-replicative complex assembly is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal pre-RC assembly" EXACT [PomBase:mah] synonym: "normal pre-replicative complex assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal pre-replicative complex assembly during vegetative growth" EXACT [PomBase:mah] synonym: "normal pre-replicative complex formation" EXACT [GO:0006267, PomBase:mah] is_a: FYPO:0001319 ! normal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006267 ! pre-replicative complex assembly involved in nuclear cell cycle DNA replication intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006267 ! pre-replicative complex assembly involved in nuclear cell cycle DNA replication relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-11-12T13:39:24Z [Term] id: FYPO:0004005 name: increased spatial extent of chromatin binding def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which a gene product binds chromatin over a larger portion of the chromosome than normal." [PMID:18753627, PomBase:mah] is_a: FYPO:0002576 ! abnormal chromatin binding created_by: midori creation_date: 2014-11-12T13:40:59Z [Term] id: FYPO:0004006 name: normal protein level during cellular response to menadione def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during a cellular response to menadione is normal (i.e. indistinguishable from wild type). Total protein or a specific protein may be affected." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein accumulation during cellular response to menadione" RELATED [PomBase:mah] synonym: "normal protein level during cellular response to menadione during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein level during cellular response to menadione during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000833 ! normal protein level during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0036245 ! cellular response to menadione intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0036245 ! cellular response to menadione relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2014-11-12T13:49:44Z [Term] id: FYPO:0004007 name: decreased protein level during cellular response to menadione def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during a cellular response to menadione is lower than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein accumulation during cellular response to menadione" RELATED [PomBase:mah] synonym: "decreased protein level during cellular response to menadione during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein level during cellular response to menadione during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein level during cellular response to menadione" EXACT [PomBase:mah] is_a: FYPO:0001324 ! decreased protein level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0036245 ! cellular response to menadione intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0036245 ! cellular response to menadione relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2014-11-12T13:53:46Z [Term] id: FYPO:0004008 name: normal rRNA transcription def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription of ribosomal DNA into ribosomal RNA occurs to a normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal rDNA transcription" EXACT [PomBase:mah] synonym: "normal ribosomal RNA transcription" EXACT [PomBase:mah] synonym: "normal rRNA transcription during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal rRNA transcription during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001855 ! normal transcription during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0009303 ! rRNA transcription intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0009303 ! rRNA transcription relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-11-12T14:04:59Z [Term] id: FYPO:0004009 name: decreased rRNA transcription def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription of ribosomal DNA into ribosomal RNA occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased rDNA transcription" EXACT [PomBase:mah] synonym: "decreased ribosomal RNA transcription" EXACT [PomBase:mah] synonym: "decreased rRNA transcription during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased rRNA transcription during vegetative growth" EXACT [PomBase:mah] synonym: "reduced rRNA transcription" EXACT [PomBase:mah] is_a: FYPO:0000781 ! decreased transcription during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0009303 ! rRNA transcription relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0009303 ! rRNA transcription created_by: midori creation_date: 2014-11-12T14:08:28Z [Term] id: FYPO:0004010 name: decreased translation of ribosomal proteins def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of translation of one or more ribosomal proteins is decreased." [PMID:2839305, PomBase:mah] synonym: "reduced translation of ribosomal proteins" EXACT [PomBase:mah] is_a: FYPO:0001798 ! decreased translation created_by: midori creation_date: 2014-11-12T14:10:21Z [Term] id: FYPO:0004011 name: increased degradation of ribosomal proteins def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of degradation of one or more ribosomal proteins is increased." [PMID:2839305, PomBase:mah] synonym: "increased degradation of ribosomal proteins during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased degradation of ribosomal proteins during vegetative growth" EXACT [GO:0030163, PomBase:mah] synonym: "increased ribosomal protein breakdown" EXACT [GO:0030163] synonym: "increased ribosomal protein catabolic process" EXACT [GO:0030163, PomBase:mah] synonym: "increased ribosomal protein catabolism" EXACT [GO:0030163, PomBase:mah] synonym: "increased ribosomal protein degradation cycle" RELATED [PomBase:mah] is_a: FYPO:0000847 ! increased protein degradation during vegetative growth created_by: midori creation_date: 2014-11-12T14:11:25Z [Term] id: FYPO:0004012 name: normal cell surface pyruvylated galactose level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of 4,6-pyruvylated D-galactose (4,6-O-[(1R)-1-carboxyethylidene]-D-galactose) measured at the cell surface is normal (i.e. indistinguishable from wild type). The cell surface refers to the external part of the cell wall and/or plasma membrane." [PMID:25195688, PomBase:mah] synonym: "normal cell surface 4,6-4,6-O-[(1R)-1-carboxyethylidene]-D-galactose level" EXACT [CHEBI:61747] synonym: "normal cell surface 4,6-pyruvylated D-galactose level" EXACT [CHEBI:4\,6-pyruvylated D-galactose, PomBase:mah] synonym: "normal cell surface PvGal level" EXACT [PMID:25195688] synonym: "normal cell surface pyruvylated galactose level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cell surface pyruvylated galactose level during vegetative growth" EXACT [PomBase:mah] synonym: "normal level of pyruvylated galactose at cell surface" EXACT [PomBase:mah] is_a: FYPO:0001313 ! normal subcellular component during vegetative growth is_a: FYPO:0001316 ! normal level of substance in cell during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0009986 ! cell surface intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:61747 ! 4,6-O-[(1R)-1-carboxyethylidene]-D-galactose relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0009986 ! cell surface relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:61747 ! 4,6-O-[(1R)-1-carboxyethylidene]-D-galactose created_by: midori creation_date: 2014-11-13T15:00:50Z [Term] id: FYPO:0004013 name: decreased cell surface pyruvylated galactose level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of 4,6-pyruvylated D-galactose (4,6-O-[(1R)-1-carboxyethylidene]-D-galactose) measured at the cell surface is lower than normal. The cell surface refers to the external part of the cell wall and/or plasma membrane." [PMID:25195688, PomBase:mah] synonym: "decreased cell surface 4,6-4,6-O-[(1R)-1-carboxyethylidene]-D-galactose level" EXACT [CHEBI:61747] synonym: "decreased cell surface 4,6-pyruvylated D-galactose level" EXACT [CHEBI:4\,6-pyruvylated D-galactose, PomBase:mah] synonym: "decreased cell surface PvGal level" EXACT [PMID:25195688] synonym: "decreased cell surface pyruvylated galactose level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cell surface pyruvylated galactose level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased level of pyruvylated galactose at cell surface" EXACT [PomBase:mah] synonym: "reduced cell surface pyruvylated galactose level" EXACT [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: FYPO:0001329 ! decreased level of substance in cell during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0009986 ! cell surface intersection_of: towards CHEBI:61747 ! 4,6-O-[(1R)-1-carboxyethylidene]-D-galactose relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0009986 ! cell surface relationship: towards CHEBI:61747 ! 4,6-O-[(1R)-1-carboxyethylidene]-D-galactose created_by: midori creation_date: 2014-11-13T15:06:16Z [Term] id: FYPO:0004014 name: normal mitotic cell cycle regulation during cellular response to UV def: "A cellular response phenotype observed in the vegetative growth phase of the life cycle in which the regulation of the mitotic cell cycle in response to ultraviolet light (UV) is normal (i.e. indistinguishable from wild type). Normally, cell cycle progression is slowed or arrested transiently following exposure to UV." [PMID:7957098, PomBase:mah] synonym: "normal cell cycle regulation during cellular response to UV" EXACT [PomBase:mah] synonym: "normal mitotic cell cycle delay following UV exposure" EXACT [PomBase:mah] synonym: "normal mitotic cell cycle regulation during cellular response to ultraviolet light" EXACT [PomBase:mah] synonym: "normal mitotic cell cycle regulation during cellular response to UV during vegetative growth" EXACT [PomBase:mah] synonym: "normal mitotic cell cycle regulation in response to UV" EXACT [PomBase:mah] is_a: FYPO:0001928 ! normal regulation of mitotic cell cycle intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0034644 ! cellular response to UV intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0007346 ! regulation of mitotic cell cycle intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0034644 ! cellular response to UV relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0007346 ! regulation of mitotic cell cycle relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-11-19T11:29:45Z [Term] id: FYPO:0004015 name: mitochondria present in normal numbers def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which a cell contains a normal number of mitochondria." [PMID:2065367, PomBase:mah] synonym: "mitochondria present in normal numbers during mitotic cell cycle" EXACT [PomBase:mah] synonym: "mitochondria present in normal numbers during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001313 ! normal subcellular component during vegetative growth is_a: PATO:0001905 ! has normal numbers of parts of type intersection_of: PATO:0001905 ! has normal numbers of parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005739 ! mitochondrion relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005739 ! mitochondrion created_by: midori creation_date: 2014-11-19T14:35:46Z [Term] id: FYPO:0004016 name: normal cellular mtDNA level def: "A cell phenotype in which the amount of mitochondrial DNA measured in a cell is normal (i.e. indistinguishable from wild type)." [PMID:2065367, PomBase:mah] synonym: "normal mitochondrial DNA content" EXACT [PomBase:mah] synonym: "normal mitochondrial DNA level" EXACT [PomBase:mah] synonym: "normal mtDNA level" EXACT [PomBase:mah] synonym: "normal mtDNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal mtDNA level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001383 ! normal DNA content created_by: midori creation_date: 2014-11-19T14:38:42Z [Term] id: FYPO:0004017 name: normal cytochrome-c oxidase activity def: "A molecular function phenotype in which the observed rate of cytochrome-c oxidase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: Also consider using the cellular process phenotype term 'normal cellular respiration' (FYPO:0000566). is_a: FYPO:0000660 ! normal catalytic activity is_a: FYPO:0002115 ! normal transporter activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004129 ! cytochrome-c oxidase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0004129 ! cytochrome-c oxidase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-11-19T14:41:26Z [Term] id: FYPO:0004018 name: normal mitochondrial electron transport, NADH to ubiquinone def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of mitochondrial electron transport from NADH to ubiquinone is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal mitochondrial electron transport, NADH to ubiquinone, during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal mitochondrial electron transport, NADH to ubiquinone, during vegetative growth" EXACT [PomBase:mah] synonym: "normal NADH cytochrome c oxidoreductase" RELATED [PMID:2065367] synonym: "normal NADH dehydrogenase (quinone) activity and ubiquinol-cytochrome-c reductase activity" RELATED [PMID:2065367, PomBase:vw] is_a: FYPO:0000859 ! normal metabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006120 ! mitochondrial electron transport, NADH to ubiquinone intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006120 ! mitochondrial electron transport, NADH to ubiquinone relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-11-19T14:42:56Z [Term] id: FYPO:0004019 name: normal mitochondrial electron transport, succinate to ubiquinone def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of mitochondrial electron transport from succinate to ubiquinone is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal mitochondrial electron transport, succinate to ubiquinone, during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal mitochondrial electron transport, succinate to ubiquinone, during vegetative growth" EXACT [PomBase:mah] synonym: "normal succinate cytochrome c oxidoreductase" RELATED [PMID:2065367] synonym: "normal succinate dehydrogenase (ubiquinone) activity and ubiquinol-cytochrome-c reductase activity" RELATED [PMID:2065367, PomBase:vw] is_a: FYPO:0000859 ! normal metabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006121 ! mitochondrial electron transport, succinate to ubiquinone intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006121 ! mitochondrial electron transport, succinate to ubiquinone relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-11-19T14:44:36Z [Term] id: FYPO:0004020 name: decreased mitochondrial electron transport, succinate to ubiquinone def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of mitochondrial electron transport from succinate to ubiquinone is decreased." [GO:0006121, PomBase:mah] synonym: "decreased mitochondrial electron transport, succinate to ubiquinone, during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased mitochondrial electron transport, succinate to ubiquinone, during vegetative growth" EXACT [PomBase:mah] synonym: "decreased succinate cytochrome c oxidoreductase" RELATED [PMID:2065367] synonym: "decreased succinate dehydrogenase (ubiquinone) activity and ubiquinol-cytochrome-c reductase activity" RELATED [PMID:2065367, PomBase:vw] synonym: "reduced mitochondrial electron transport, succinate to ubiquinone" EXACT [PomBase:mah] is_a: FYPO:0001348 ! cellular metabolism phenotype during vegetative growth is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006121 ! mitochondrial electron transport, succinate to ubiquinone relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006121 ! mitochondrial electron transport, succinate to ubiquinone created_by: midori creation_date: 2014-11-19T14:45:44Z [Term] id: FYPO:0004021 name: long polar microtubules def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells form polar microtubules that are longer than normal. Polar microtubules are the spindle microtubules that come from each pole and overlap at the spindle midzone." [GO:0005827, PomBase:mah] synonym: "elongated polar microtubules" EXACT [PomBase:mah] synonym: "long polar microtubules during mitotic cell cycle" RELATED [PomBase:mah] synonym: "long polar microtubules during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000055 ! long microtubules intersection_of: PATO:0000573 ! increased length intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005827 ! polar microtubule relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005827 ! polar microtubule created_by: midori creation_date: 2014-11-19T15:05:50Z [Term] id: FYPO:0004022 name: abnormal cell cycle arrest in mitotic metaphase with long polar microtubules def: "A cellular process phenotype in which progression through the mitotic cell cycle is arrested in metaphase under conditions where arrest does not normally occur, with polar microtubules that are longer than normal." [PMID:16079915, PomBase:mah] synonym: "abnormal cell cycle arrest in mitotic metaphase with condensed chromosomes and long polar microtubules" EXACT [Pombase:vw] synonym: "abnormal cell cycle arrest in mitotic metaphase with elongated polar microtubules" EXACT [PomBase:mah] synonym: "abnormal cell cycle arrest in mitotic metaphase with long polar microtubules during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal mitotic cell cycle arrest in metaphase with long polar microtubules" EXACT [GO:0000089] is_a: FYPO:0000620 ! abnormal cell cycle arrest in mitotic metaphase is_a: FYPO:0004040 ! mitotic cell cycle arrest phenotype intersection_of: during GO:0000089 ! mitotic metaphase intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0004021 ! long polar microtubules intersection_of: inheres_in GO:0071850 ! mitotic cell cycle arrest intersection_of: qualifier PATO:0000467 ! present relationship: during GO:0000089 ! mitotic metaphase relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0004021 ! long polar microtubules relationship: inheres_in GO:0071850 ! mitotic cell cycle arrest relationship: qualifier PATO:0000467 ! present created_by: midori creation_date: 2014-11-19T15:08:19Z [Term] id: FYPO:0004023 name: increased duration of protein localization to mitotic spindle def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which one or more proteins is localized to the mitotic spindle for a longer time than normal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased duration of protein localisation to mitotic spindle" EXACT [PomBase:mah] synonym: "increased duration of protein localization to spindle during vegetative growth" EXACT [PomBase:mah] synonym: "prolonged protein localization to mitotic spindle" EXACT [PomBase:vw] is_a: FYPO:0002824 ! abnormal protein localization to mitotic spindle is_a: PATO:0000498 ! increased duration intersection_of: PATO:0000498 ! increased duration intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902480 ! protein localization to mitotic spindle relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902480 ! protein localization to mitotic spindle created_by: midori creation_date: 2014-11-19T15:12:15Z [Term] id: FYPO:0004024 name: normal protein localization to cytoplasmic stress granule def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to cytoplasmic stress granules is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to cytoplasmic stress granule" EXACT [PomBase:mah] synonym: "normal protein localization to cytoplasmic stress granule during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to cytoplasmic stress granule during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein localization to stress granule" EXACT [GO:0010494] is_a: FYPO:0000644 ! normal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903608 ! protein localization to cytoplasmic stress granule intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903608 ! protein localization to cytoplasmic stress granule relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-11-19T15:13:47Z [Term] id: FYPO:0004025 name: resistance to carbendazim def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of the tubulin poison carbendazim (mecarzole; MBC) than normal." [PomBase:mah] synonym: "resistance to carbendazim during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to carbendazim during vegetative growth" EXACT [PomBase:mah] synonym: "resistance to MBC" EXACT [CHEBI:3392] synonym: "resistant to carbendazim" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:3392 ! carbendazim relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:3392 ! carbendazim created_by: midori creation_date: 2014-11-19T15:41:42Z [Term] id: FYPO:0004026 name: loss of template switch-mediated chromosomal rearrangement during replication fork processing def: "A cell phenotype in which the increase in gross chromosomal rearrangements that normally results from synthesis template switching during processing of arrested replication forks is diminished or abolished." [PMID:25313826, PomBase:mah] is_a: FYPO:0003587 ! loss of gross chromosomal rearrangement during replication fork processing created_by: midori creation_date: 2014-11-19T15:43:04Z [Term] id: FYPO:0004027 name: normal 5' deoxyribonuclease (pyrimidine dimer) activity def: "A molecular function phenotype in which the observed rate of 5' deoxyribonuclease (pyrimidine dimer) activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:1990043 ! 5' deoxyribonuclease (pyrimidine dimer) activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:1990043 ! 5' deoxyribonuclease (pyrimidine dimer) activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-11-19T17:24:06Z [Term] id: FYPO:0004028 name: abnormal 5' deoxyribonuclease (pyrimidine dimer) activity def: "A molecular function phenotype in which the observed rate of 5' deoxyribonuclease (pyrimidine dimer) activity is abnormal." [PomBase:mah] is_a: FYPO:0002036 ! abnormal endodeoxyribonuclease activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:1990043 ! 5' deoxyribonuclease (pyrimidine dimer) activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:1990043 ! 5' deoxyribonuclease (pyrimidine dimer) activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-11-19T17:25:49Z [Term] id: FYPO:0004029 name: abolished 5' deoxyribonuclease (pyrimidine dimer) activity def: "A molecular function phenotype in which 5' deoxyribonuclease (pyrimidine dimer) activity is absent." [PomBase:mah] synonym: "5' deoxyribonuclease (pyrimidine dimer) activity abolished" EXACT [PomBase:mah] is_a: FYPO:0003164 ! abolished nuclease activity is_a: FYPO:0004028 ! abnormal 5' deoxyribonuclease (pyrimidine dimer) activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:1990043 ! 5' deoxyribonuclease (pyrimidine dimer) activity relationship: towards GO:1990043 ! 5' deoxyribonuclease (pyrimidine dimer) activity created_by: midori creation_date: 2014-11-19T17:25:54Z [Term] id: FYPO:0004030 name: decreased 5' deoxyribonuclease (pyrimidine dimer) activity def: "A molecular function phenotype in which the observed rate of 5' deoxyribonuclease (pyrimidine dimer) activity is decreased." [PomBase:mah] synonym: "reduced 5' deoxyribonuclease (pyrimidine dimer) activity" EXACT [PomBase:mah] is_a: FYPO:0002037 ! decreased endodeoxyribonuclease activity is_a: FYPO:0004028 ! abnormal 5' deoxyribonuclease (pyrimidine dimer) activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:1990043 ! 5' deoxyribonuclease (pyrimidine dimer) activity relationship: inheres_in GO:1990043 ! 5' deoxyribonuclease (pyrimidine dimer) activity created_by: midori creation_date: 2014-11-19T17:26:08Z [Term] id: FYPO:0004031 name: decreased UV-damage excision repair def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which UV-damage excision repair occurs to a lower extent than normal. UV-damage excision repair is a DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site, and that acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs)." [GO:0070914, PomBase:mah] synonym: "decreased cyclobutane pyrimidine dimer repair" NARROW [GO:0070914] synonym: "decreased pyrimidine-pyrimidone 6-4 photoproduct repair" NARROW [GO:0070914] synonym: "decreased UV-damage excision repair during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased UV-damage excision repair during vegetative growth" EXACT [PomBase:mah] synonym: "reduced removal of 6-4 photoproducts" NARROW [GO:0070914, PomBase:vw] synonym: "reduced removal of cyclobutane pyrimidine dimers" NARROW [GO:0070914, PomBase:vw] synonym: "reduced UV-damage excision repair" EXACT [PomBase:mah] is_a: FYPO:0000188 ! abnormal DNA repair is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0070914 ! UV-damage excision repair relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0070914 ! UV-damage excision repair created_by: midori creation_date: 2014-11-19T17:29:31Z [Term] id: FYPO:0004032 name: increased protein localization to chromatin at rDNA def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to chromatin at ribosomal DNA repeat regions is increased." [PMID:25392932, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to chromatin at rDNA" EXACT [PomBase:mah] synonym: "increased protein localization to chromatin at rDNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein localization to chromatin at rDNA during vegetative growth" EXACT [PomBase:mah] synonym: "increased protein localization to chromatin at ribosomal DNA" EXACT [PomBase:mah] is_a: FYPO:0003011 ! increased protein localization to chromatin intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071168 ! protein localization to chromatin intersection_of: occurs_at SO:0001637 ! rRNA_gene relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071168 ! protein localization to chromatin relationship: occurs_at SO:0001637 ! rRNA_gene created_by: midori creation_date: 2014-11-25T10:59:45Z [Term] id: FYPO:0004033 name: increased protein localization to chromatin at tRNA genes def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to chromatin at tRNA genes is increased." [PMID:25392932, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to chromatin at tRNA genes" EXACT [PomBase:mah] synonym: "increased protein localization to chromatin at transfer RNA genes" EXACT [PomBase:mah] synonym: "increased protein localization to chromatin at tRNA genes during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein localization to chromatin at tRNA genes during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003011 ! increased protein localization to chromatin intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071168 ! protein localization to chromatin intersection_of: occurs_at SO:0001272 ! tRNA_gene relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071168 ! protein localization to chromatin relationship: occurs_at SO:0001272 ! tRNA_gene created_by: midori creation_date: 2014-11-25T11:03:58Z [Term] id: FYPO:0004034 name: decreased glutathione transferase activity def: "A molecular function phenotype in which the observed rate of glutathione transferase activity is decreased." [PomBase:mah] synonym: "reduced glutathione transferase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0003980 ! abnormal glutathione transferase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004364 ! glutathione transferase activity relationship: inheres_in GO:0004364 ! glutathione transferase activity created_by: midori creation_date: 2014-11-25T11:13:07Z [Term] id: FYPO:0004035 name: abnormal thioredoxin-disulfide reductase activity def: "A molecular function phenotype in which the observed rate of thioredoxin-disulfide reductase activity is abnormal." [PomBase:mah] is_a: FYPO:0000689 ! abnormal oxidoreductase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004791 ! thioredoxin-disulfide reductase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004791 ! thioredoxin-disulfide reductase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-11-25T11:14:45Z [Term] id: FYPO:0004036 name: increased thioredoxin-disulfide reductase activity def: "A molecular function phenotype in which the observed rate of thioredoxin-disulfide reductase activity is increased." [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0004035 ! abnormal thioredoxin-disulfide reductase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0004791 ! thioredoxin-disulfide reductase activity relationship: inheres_in GO:0004791 ! thioredoxin-disulfide reductase activity created_by: midori creation_date: 2014-11-25T11:14:50Z [Term] id: FYPO:0004037 name: decreased protein level during cellular response to mercury ion def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during a cellular response to mercury ions is lower than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein accumulation during cellular response to mercury ion" RELATED [PomBase:mah] synonym: "decreased protein level during cellular response to mercury" EXACT [PomBase:mah] synonym: "decreased protein level during cellular response to mercury ion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein level during cellular response to mercury ion during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein level during cellular response to mercury ion" EXACT [PomBase:mah] is_a: FYPO:0001324 ! decreased protein level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0071288 ! cellular response to mercury ion intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0071288 ! cellular response to mercury ion relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2014-11-25T11:17:44Z [Term] id: FYPO:0004038 name: delayed increase in RNA level during cellular response to hydrogen peroxide def: "A cell phenotype in which an increase in RNA level that occurs as part of a cellular response to hydrogen peroxide begins later than normal. Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [PMID:9450957, PomBase:mah] synonym: "delayed increase in RNA level during cellular response to H2O2" EXACT [PomBase:mah] synonym: "delayed increase in transcript level during cellular response to hydrogen peroxide" EXACT [PomBase:mah] is_a: FYPO:0000194 ! abnormal cellular response to hydrogen peroxide created_by: midori creation_date: 2014-12-16T14:47:06Z [Term] id: FYPO:0004039 name: abolished primary amine oxidase activity def: "A molecular function phenotype in which primary amine oxidase activity is absent." [PomBase:mah] synonym: "primary amine oxidase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0008131 ! primary amine oxidase activity relationship: towards GO:0008131 ! primary amine oxidase activity created_by: midori creation_date: 2014-11-25T11:22:59Z [Term] id: FYPO:0004040 name: mitotic cell cycle arrest phenotype def: "A cell cycle phenotype that affects or involves the normal or abnormal occurrence of mitotic cell cycle arrest. In mitotic cell cycle arrest, progression through the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, or M)." [PomBase:mah] synonym: "cell cycle arrest phenotype during mitotic cell cycle" EXACT [PomBase:mah] synonym: "cell cycle arrest phenotype during vegetative growth" EXACT [PomBase:mah] synonym: "fission yeast mitotic cell cycle arrest phenotype" EXACT [PomBase:mah] is_a: FYPO:0001024 ! cell cycle arrest phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: inheres_in GO:0071850 ! mitotic cell cycle arrest relationship: inheres_in GO:0071850 ! mitotic cell cycle arrest created_by: midori creation_date: 2014-11-27T12:18:23Z [Term] id: FYPO:0004041 name: normal primary amine oxidase activity def: "A molecular function phenotype in which the observed rate of a primary amine oxidase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0008131 ! primary amine oxidase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0008131 ! primary amine oxidase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-11-25T11:23:49Z [Term] id: FYPO:0004042 name: fragmented septum def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell forms pieces of a septum rather than a septum that completely bisects the cell." [PMID:21931816, PomBase:mah] synonym: "fragmented septum during mitotic cell cycle" RELATED [PomBase:mah] synonym: "fragmented septum during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002023 ! abnormal septum morphology during vegetative growth is_a: PATO:0001444 ! broken intersection_of: PATO:0001444 ! broken intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000935 ! barrier septum relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000935 ! barrier septum created_by: midori creation_date: 2014-11-25T11:51:06Z [Term] id: FYPO:0004043 name: tetranucleate vegetative cell def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which a cell contains four nuclei." [PomBase:mah] synonym: "tetranucleate cells during vegetative growth" EXACT [PomBase:al] synonym: "tetranucleate during vegetative growth" EXACT [PomBase:mah] synonym: "tetranucleate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000061 ! multinucleate vegetative cell created_by: midori creation_date: 2014-11-25T11:58:10Z [Term] id: FYPO:0004044 name: elongated tetranucleate vegetative cell def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which a cell contains four nuclei and is longer than normal." [PomBase:mah] synonym: "elongated tetranucleate cells during vegetative growth" EXACT [PomBase:al] synonym: "elongated tetranucleate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "long tetranucleate vegetative cell" EXACT [PomBase:mah] is_a: FYPO:0003342 ! elongated multinucleate cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: has_part FYPO:0001122 ! elongated vegetative cell intersection_of: has_part FYPO:0004043 ! tetranucleate vegetative cell relationship: has_part FYPO:0001122 ! elongated vegetative cell relationship: has_part FYPO:0004043 ! tetranucleate vegetative cell created_by: midori creation_date: 2014-11-25T11:59:21Z [Term] id: FYPO:0004045 name: elongated tetranucleate vegetative cell with fragmented septum def: "A cell morphology phenotype in which vegetative a cell is longer than normal, and contains four nuclei and pieces of a septum that does not completely bisect the cell." [PMID:21931816, PomBase:mah] synonym: "elongated tetranucleate cells with fragmented septum during vegetative growth" EXACT [PomBase:al] synonym: "elongated tetranucleate vegetative cell with fragmented septum during mitotic cell cycle" RELATED [PomBase:mah] synonym: "long tetranucleate vegetative cell with fragmented septum" EXACT [PomBase:mah] is_a: FYPO:0004044 ! elongated tetranucleate vegetative cell is_a: FYPO:0004046 ! tetranucleate vegetative cell with fragmented septum intersection_of: FYPO:0000002 ! cell phenotype intersection_of: has_part FYPO:0001122 ! elongated vegetative cell intersection_of: has_part FYPO:0004042 ! fragmented septum intersection_of: has_part FYPO:0004043 ! tetranucleate vegetative cell relationship: has_part FYPO:0001122 ! elongated vegetative cell relationship: has_part FYPO:0004042 ! fragmented septum relationship: has_part FYPO:0004043 ! tetranucleate vegetative cell created_by: midori creation_date: 2014-11-25T12:00:56Z [Term] id: FYPO:0004046 name: tetranucleate vegetative cell with fragmented septum def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which a cell contains four nuclei and pieces of a septum that does not completely bisect the cell." [PMID:21931816, PomBase:mah] synonym: "tetranucleate cells with fragmented septum during vegetative growth" EXACT [PomBase:mah] synonym: "tetranucleate vegetative cell with fragmented septum during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: has_part FYPO:0004042 ! fragmented septum intersection_of: has_part FYPO:0004043 ! tetranucleate vegetative cell relationship: has_part FYPO:0004042 ! fragmented septum relationship: has_part FYPO:0004043 ! tetranucleate vegetative cell created_by: midori creation_date: 2014-11-25T12:02:21Z [Term] id: FYPO:0004047 name: binucleate vegetative cell with fragmented septum def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which a cell contains two nuclei and pieces of a septum that does not completely bisect the cell." [PMID:21931816, PomBase:mah] synonym: "binucleate cells with fragmented septum during vegetative growth" EXACT [PomBase:mah] synonym: "binucleate vegetative cell with fragmented septum during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: has_part FYPO:0001222 ! binucleate vegetative cell intersection_of: has_part FYPO:0004042 ! fragmented septum relationship: has_part FYPO:0001222 ! binucleate vegetative cell relationship: has_part FYPO:0004042 ! fragmented septum created_by: midori creation_date: 2014-11-25T12:04:23Z [Term] id: FYPO:0004048 name: abnormal glutathione peroxidase activity def: "A molecular function phenotype in which the observed rate of glutathione peroxidase activity is abnormal." [PomBase:mah] is_a: FYPO:0000689 ! abnormal oxidoreductase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004602 ! glutathione peroxidase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004602 ! glutathione peroxidase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-11-25T12:11:36Z [Term] id: FYPO:0004049 name: increased glutathione peroxidase activity def: "A molecular function phenotype in which the observed rate of glutathione peroxidase activity is increased." [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0004048 ! abnormal glutathione peroxidase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0004602 ! glutathione peroxidase activity relationship: inheres_in GO:0004602 ! glutathione peroxidase activity created_by: midori creation_date: 2014-11-25T12:11:42Z [Term] id: FYPO:0004050 name: decreased glutathione transferase activity during stationary phase def: "A molecular function phenotype in which the observed rate of glutathione transferase activity is decreased in a cell culture in stationary phase." [PomBase:mah] synonym: "decreased glutathione transferase activity in stationary phase" EXACT [PomBase:mah] synonym: "reduced glutathione transferase activity during stationary phase" EXACT [PomBase:mah] is_a: FYPO:0004034 ! decreased glutathione transferase activity created_by: midori creation_date: 2014-11-25T12:49:00Z [Term] id: FYPO:0004051 name: increased glutathione transferase activity during stationary phase def: "A molecular function phenotype in which the observed rate of glutathione transferase activity is increased in a cell culture in stationary phase." [PomBase:mah] synonym: "increased glutathione transferase activity in stationary phase" EXACT [PomBase:mah] is_a: FYPO:0003981 ! increased glutathione transferase activity created_by: midori creation_date: 2014-11-25T12:52:09Z [Term] id: FYPO:0004052 name: RNA absent from cell during cellular response to hydrogen peroxide def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell is too low to detect during a cellular response to hydrogen peroxide. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "RNA absent from cell during cellular response to H2O2" EXACT [PomBase:mah] synonym: "RNA absent from cell during cellular response to hydrogen peroxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "RNA absent from cell during cellular response to hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] synonym: "transcripts absent from cell during cellular response to hydrogen peroxide" EXACT [PomBase:vw] synonym: "undetectable RNA level during cellular response to hydrogen peroxide" EXACT [PomBase:mah] is_a: FYPO:0001116 ! decreased RNA level during cellular response to hydrogen peroxide is_a: FYPO:0003161 ! RNA absent from cell during vegetative growth intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0070301 ! cellular response to hydrogen peroxide intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: during GO:0070301 ! cellular response to hydrogen peroxide relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-11-25T12:53:07Z [Term] id: FYPO:0004053 name: cut during cellular response to UV def: "A cut phenotype that is observed when a cell is exposed to ultraviolet light. In a cut phenotype, a cell undergoes septation despite abnormal chromosome segregation, such that the septum physically divides the nucleus into two parts, and produces inviable daughter cells." [PomBase:mah] synonym: "cut during cellular response to ultraviolet light" EXACT [PomBase:mah] synonym: "cut during cellular response to UV during mitotic cell cycle" RELATED [PomBase:mah] synonym: "cut during cellular response to UV during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003165 ! cut intersection_of: FYPO:0003165 ! cut intersection_of: during GO:0034644 ! cellular response to UV relationship: during GO:0034644 ! cellular response to UV created_by: midori creation_date: 2014-11-25T14:23:33Z [Term] id: FYPO:0004054 name: abolished protein localization to nucleus during cellular response to salt stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleus is abolished during a cellular response to salt stress." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to nucleus during cellular response to salt stress" EXACT [PomBase:mah] synonym: "abolished protein localization to nucleus during cellular response to salt stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to nucleus during cellular response to salt stress during vegetative growth" EXACT [PomBase:mah] synonym: "abolished protein localization to nucleus during salt stress" EXACT [PomBase:al] synonym: "protein localization to nucleus abolished during cellular response to salt stress" EXACT [PomBase:mah] is_a: FYPO:0001424 ! abolished protein localization to nucleus during vegetative growth intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0071472 ! cellular response to salt stress intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0034504 ! protein localization to nucleus relationship: during GO:0071472 ! cellular response to salt stress relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0034504 ! protein localization to nucleus created_by: midori creation_date: 2014-11-25T14:26:16Z [Term] id: FYPO:0004055 name: decreased protein localization to nucleus during cellular response to salt stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleus is decreased during a cellular response to salt stress." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to nucleus during cellular response to salt stress" EXACT [PomBase:mah] synonym: "decreased protein localization to nucleus during cellular response to salt stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to nucleus during cellular response to salt stress during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein localization to nucleus during salt stress" EXACT [PomBase:al] synonym: "reduced protein localization to nucleus during cellular response to salt stress" EXACT [PomBase:mah] is_a: FYPO:0001514 ! decreased protein localization to nucleus during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0071472 ! cellular response to salt stress intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034504 ! protein localization to nucleus relationship: happens_during GO:0071472 ! cellular response to salt stress relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034504 ! protein localization to nucleus created_by: midori creation_date: 2014-11-25T14:28:03Z [Term] id: FYPO:0004056 name: decreased protein localization to nucleus, with protein mislocalized to cytoplasm def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleus is decreased, and some of the protein is present in the cytoplasm instead." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to nucleus, with protein mislocalised to cytoplasm" EXACT [PomBase:mah] synonym: "decreased protein localization in nucleus, with protein mislocalized to cytoplasm" EXACT [GO:0034504] synonym: "decreased protein localization to nucleus, with protein mislocalized to cytoplasm, during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to nucleus, with protein mislocalized to cytoplasm, during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to nucleus, with protein mislocalized to cytoplasm" EXACT [PomBase:mah] is_a: FYPO:0001514 ! decreased protein localization to nucleus during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000783 ! protein mislocalized to cytoplasm intersection_of: inheres_in GO:0034504 ! protein localization to nucleus relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000783 ! protein mislocalized to cytoplasm relationship: inheres_in GO:0034504 ! protein localization to nucleus created_by: midori creation_date: 2014-11-25T14:28:46Z [Term] id: FYPO:0004057 name: increased intragenic meiotic recombination def: "A cellular process phenotype in which the occurrence of intragenic meiotic recombination is increased. Intragenic meiotic recombination can result in gene conversion events." [PMID:19436749, PomBase:mah] synonym: "increased intragenic meiotic recombination" EXACT [PomBase:mah] synonym: "increased meiotic intragenic recombination" EXACT [PomBase:al] is_a: FYPO:0000487 ! increased meiotic recombination created_by: midori creation_date: 2014-11-25T14:36:39Z [Term] id: FYPO:0004058 name: decreased meiotic recombination at M26 site def: "A cellular process phenotype in which the occurrence of reciprocal meiotic recombination at an M26 site in a chromosome is decreased." [PMID:19436749, PomBase:mah] synonym: "decreased meiotic recombination at M26 binding site" NARROW [PomBase:mah, SO:0001900] synonym: "reduced meiotic recombination at M26 site" EXACT [PomBase:mah] is_a: FYPO:0000485 ! decreased meiotic recombination intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0007131 ! reciprocal meiotic recombination intersection_of: occurs_at SO:0001900 ! M26_binding_site relationship: inheres_in GO:0007131 ! reciprocal meiotic recombination relationship: occurs_at SO:0001900 ! M26_binding_site created_by: midori creation_date: 2014-11-25T14:39:56Z [Term] id: FYPO:0004059 name: normal meiotic recombination at M26 site def: "A cellular process phenotype in which reciprocal meiotic recombination is normal (i.e. indistinguishable from wild type) at an M26 site in a chromosome." [PomBase:mah] synonym: "normal meiotic recombination at M26 binding site" EXACT [SO:0001900] is_a: FYPO:0000488 ! normal meiotic recombination intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0007131 ! reciprocal meiotic recombination intersection_of: occurs_at SO:0001900 ! M26_binding_site intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0007131 ! reciprocal meiotic recombination relationship: occurs_at SO:0001900 ! M26_binding_site relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-11-25T14:41:47Z [Term] id: FYPO:0004060 name: abolished endocytosis during meiotic interphase II def: "A cellular process phenotype in which endocytosis does not occur during meiotic interphase II, i.e. the phase between the end of meiosis I cytokinesis the beginning of meiosis II prophase. A phenotype may affect endocytosis of all cargoes, or of specific cargo such as a particular protein." [GO:0044844, PomBase:mah] synonym: "abolished actin-mediated endocytosis during meiotic interphase II" EXACT [PomBase:vw] synonym: "abolished protein internalization during meiotic interphase II" NARROW [PomBase:vw] synonym: "absent endocytosis during meiotic interphase II" EXACT [PomBase:mah] synonym: "endocytosis abolished during meiotic interphase II" EXACT [PomBase:mah] is_a: FYPO:0003886 ! abnormal endocytosis is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0044844 ! meiotic interphase II intersection_of: towards GO:0006897 ! endocytosis relationship: during GO:0044844 ! meiotic interphase II relationship: towards GO:0006897 ! endocytosis created_by: midori creation_date: 2014-11-25T15:47:31Z [Term] id: FYPO:0004061 name: decreased UV-damage excision repair during mitotic G1 phase def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which UV-damage excision repair occurs to a lower extent than normal during G1 phase of the mitotic cell cycle. UV-damage excision repair is a DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site, and that acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs)." [GO:0070914, PomBase:mah] synonym: "decreased UV-damage excision repair during G1 phase of mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased UV-damage excision repair during mitotic G1 during vegetative growth" EXACT [PomBase:mah] synonym: "reduced UV-damage excision repair during mitotic G1 phase" EXACT [PomBase:mah] is_a: FYPO:0004031 ! decreased UV-damage excision repair intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0000080 ! mitotic G1 phase intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0070914 ! UV-damage excision repair relationship: happens_during GO:0000080 ! mitotic G1 phase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0070914 ! UV-damage excision repair created_by: midori creation_date: 2014-11-25T16:13:13Z [Term] id: FYPO:0004062 name: increased duration of protein phosphorylation during cellular response to salt stress def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the duration of protein phosphorylation is increased during a cellular response to salt stress. All phosphorylation may be affected, or only phosphorylation of specific proteins, or even specific sites within specific proteins." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased duration of protein phosphorylation during cellular response to salt stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased duration of protein phosphorylation during cellular response to salt stress during vegetative growth" EXACT [PomBase:mah] synonym: "prolonged protein phosphorylation during cellular response to salt stress" EXACT [PomBase:mah] is_a: FYPO:0000548 ! increased duration of protein modification intersection_of: PATO:0000498 ! increased duration intersection_of: happens_during GO:0071472 ! cellular response to salt stress intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0071472 ! cellular response to salt stress relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2014-11-25T16:16:58Z [Term] id: FYPO:0004063 name: normal protein localization to cytoplasm during cellular response to salt stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to all or part of the cytoplasm is normal (i.e. indistinguishable from wild type) during a cellular response to salt stress." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to cytoplasm during cellular response to salt stress" EXACT [PomBase:mah] synonym: "normal protein localization to cytoplasm during cellular response to salt stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to cytoplasm during cellular response to salt stress during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein localization to cytoplasm during salt stress" EXACT [PomBase:al] is_a: FYPO:0001788 ! normal protein localization to cytoplasm intersection_of: FYPO:0001788 ! normal protein localization to cytoplasm intersection_of: happens_during GO:0071472 ! cellular response to salt stress relationship: happens_during GO:0071472 ! cellular response to salt stress created_by: midori creation_date: 2014-11-25T16:18:38Z [Term] id: FYPO:0004064 name: abnormal transcription def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription of RNA from one or more DNA templates is abnormal." [GO:0006351, PomBase:mah] synonym: "abnormal DNA-dependent transcription" EXACT [GO:0006351] synonym: "abnormal transcription during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal transcription during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal transcription, DNA-templated" EXACT [GO:0006351] is_a: FYPO:0000290 ! transcription phenotype during vegetative growth is_a: FYPO:0001363 ! abnormal metabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006351 ! transcription, DNA-templated intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006351 ! transcription, DNA-templated relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-11-25T16:38:51Z [Term] id: FYPO:0004065 name: abnormal transcription elongation from RNA polymerase II promoter def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the elongation of a transcript initiated from an RNA polymerase II promoter is abnormal." [GO:0006368, PomBase:mah] synonym: "abnormal RNA elongation from RNA polymerase II promoter" EXACT [GO:0006368] synonym: "abnormal transcription elongation from RNA polymerase II promoter during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal transcription elongation from RNA polymerase II promoter during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0004064 ! abnormal transcription intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006368 ! transcription elongation from RNA polymerase II promoter intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006368 ! transcription elongation from RNA polymerase II promoter relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-11-25T16:41:18Z [Term] id: FYPO:0004066 name: increased protein localization to chromatin at protein-coding genes def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to chromatin at one or more protein-coding genes is increased." [PMID:19328067, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to chromatin at protein-coding genes" EXACT [PomBase:mah] synonym: "increased protein localization to chromatin at protein-coding genes during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein localization to chromatin at protein-coding genes during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003011 ! increased protein localization to chromatin intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071168 ! protein localization to chromatin intersection_of: occurs_at SO:0001217 ! protein_coding_gene relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071168 ! protein localization to chromatin relationship: occurs_at SO:0001217 ! protein_coding_gene created_by: midori creation_date: 2014-11-25T16:43:55Z [Term] id: FYPO:0004067 name: decreased phosphorylation of RNA polymerase II C-terminal domain serine 2 residues def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of the serine residue at position 2 within one or more copies of the heptapeptide repeat (YSPTSPS) of the C-terminal domain of RNA polymerase II occurs to a lower extent than normal." [GO:0071619, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased phosphorylation of RNA polymerase II C-terminal domain serine 2 residues during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased phosphorylation of RNA polymerase II C-terminal domain serine 2 residues during vegetative growth" EXACT [PomBase:mah] synonym: "decreased phosphorylation of RNA polymerase II CTD serine 2 residues" EXACT [PomBase:mah] synonym: "reduced phosphorylation of RNA polymerase II C-terminal domain serine 2 residues" EXACT [PomBase:mah] is_a: FYPO:0002644 ! decreased protein serine phosphorylation during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071619 ! phosphorylation of RNA polymerase II C-terminal domain serine 2 residues relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071619 ! phosphorylation of RNA polymerase II C-terminal domain serine 2 residues created_by: midori creation_date: 2014-11-25T16:49:49Z [Term] id: FYPO:0004068 name: decreased phosphorylation of RNA polymerase II C-terminal domain serine 5 residues def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of the serine residue at position 5 within one or more copies of the heptapeptide repeat (YSPTSPS) of the C-terminal domain of RNA polymerase II occurs to a lower extent than normal." [GO:0071620, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased phosphorylation of RNA polymerase II C-terminal domain serine 5 residues during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased phosphorylation of RNA polymerase II C-terminal domain serine 5 residues during vegetative growth" EXACT [PomBase:mah] synonym: "decreased phosphorylation of RNA polymerase II CTD serine 5 residues" EXACT [PomBase:mah] synonym: "reduced phosphorylation of RNA polymerase II C-terminal domain serine 5 residues" EXACT [PomBase:mah] is_a: FYPO:0002644 ! decreased protein serine phosphorylation during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071620 ! phosphorylation of RNA polymerase II C-terminal domain serine 5 residues relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071620 ! phosphorylation of RNA polymerase II C-terminal domain serine 5 residues created_by: midori creation_date: 2014-11-25T16:51:53Z [Term] id: FYPO:0004069 name: abolished phosphorylation of RNA polymerase II C-terminal domain serine 2 residues def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of the serine residue at position 2 within one or more copies of the heptapeptide repeat (YSPTSPS) of the C-terminal domain of RNA polymerase II does not occur." [GO:0071619, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished phosphorylation of RNA polymerase II C-terminal domain serine 2 residues during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished phosphorylation of RNA polymerase II C-terminal domain serine 2 residues during vegetative growth" EXACT [PomBase:mah] synonym: "decreased phosphorylation of RNA polymerase II CTD serine 2 residues" EXACT [PomBase:mah] synonym: "phosphorylation of RNA polymerase II C-terminal domain serine 2 residues abolished" EXACT [PomBase:mah] is_a: FYPO:0002033 ! abolished protein phosphorylation during vegetative growth intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0071619 ! phosphorylation of RNA polymerase II C-terminal domain serine 2 residues relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0071619 ! phosphorylation of RNA polymerase II C-terminal domain serine 2 residues created_by: midori creation_date: 2014-11-25T16:53:04Z [Term] id: FYPO:0004070 name: RNA absent from cell during cellular response to copper ion starvation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell is too low to detect during a cellular response to copper ion starvation. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "RNA absent from cell during cellular response to copper ion starvation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "RNA absent from cell during cellular response to copper ion starvation during vegetative growth" EXACT [PomBase:mah] synonym: "RNA absent from cell during cellular response to copper starvation" EXACT [PomBase:mah] synonym: "transcripts absent from cell during cellular response to copper ion starvation" EXACT [PomBase:vw] synonym: "undetectable RNA level during cellular response to copper ion starvation" EXACT [PomBase:mah] is_a: FYPO:0003161 ! RNA absent from cell during vegetative growth is_a: FYPO:0003280 ! decreased RNA level during cellular response to copper ion starvation intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0035874 ! cellular response to copper ion starvation intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: during GO:0035874 ! cellular response to copper ion starvation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-11-27T14:03:28Z [Term] id: FYPO:0004071 name: decreased RNA level during cellular response to copper ion def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to copper ions is lower than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased RNA accumulation during cellular response to copper ion" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to copper" EXACT [PomBase:mah] synonym: "decreased RNA level during cellular response to copper ion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to copper ion during vegetative growth" EXACT [PomBase:mah] synonym: "decreased transcript level during cellular response to copper ion" EXACT [PomBase:vw] synonym: "reduced RNA level during cellular response to copper ion" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0071280 ! cellular response to copper ion intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0071280 ! cellular response to copper ion relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-11-27T14:06:20Z [Term] id: FYPO:0004072 name: RNA absent from cell during cellular response to pheromone def: "A cell phenotype in which the amount of RNA measured in a cell is too low to detect during a cellular response to a pheromone. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "transcripts absent from cell during cellular response to pheromone" EXACT [PomBase:vw] synonym: "undetectable RNA level during cellular response to pheromone" EXACT [PomBase:mah] is_a: FYPO:0001889 ! RNA absent from cell is_a: FYPO:0003426 ! decreased RNA level during cellular response to pheromone intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0071444 ! cellular response to pheromone intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: during GO:0071444 ! cellular response to pheromone relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-11-27T14:20:16Z [Term] id: FYPO:0004073 name: two cell divisions prior to cell cycle arrest in mitotic G1 phase in response to pheromone def: "A cellular process phenotype in which the occurrence of cell cycle arrest in response to a pheromone occurs in G1 phase, but begins only after the cells have undergone two rounds of cell division in the presence of the pheromone." [PMID:9034336, PomBase:mah] synonym: "two cell divisions prior to cell cycle arrest in mitotic G1 phase during cellular response to pheromone" EXACT [PomBase:mah] synonym: "two cell divisions prior to mitotic cell cycle arrest in G1 phase in response to pheromone" EXACT [PomBase:mah] synonym: "two cell divisions prior to mitotic G1 arrest in response to pheromone" EXACT [PomBase:mah] synonym: "two cell divisions prior to pheromone-induced G1 arrest" EXACT [PomBase:mah] is_a: FYPO:0004074 ! delayed cell cycle arrest in mitotic G1 phase in response to pheromone created_by: midori creation_date: 2014-11-27T14:27:50Z [Term] id: FYPO:0004074 name: delayed cell cycle arrest in mitotic G1 phase in response to pheromone def: "A cellular process phenotype in which the occurrence of cell cycle arrest in response to a pheromone occurs in G1 phase, but begins later than normal." [PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "delayed cell cycle arrest in mitotic G1 phase during cellular response to pheromone" EXACT [PomBase:mah] synonym: "delayed mitotic cell cycle arrest in G1 phase in response to pheromone" EXACT [PomBase:mah] synonym: "delayed mitotic G1 arrest in response to pheromone" EXACT [PomBase:mah] synonym: "delayed pheromone-induced G1 arrest" EXACT [PomBase:mah] is_a: FYPO:0000445 ! cell cycle arrest in mitotic G1 phase is_a: FYPO:0000530 ! abnormal mitotic cell cycle arrest in response to pheromone is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0000080 ! mitotic G1 phase intersection_of: inheres_in GO:0000751 ! mitotic cell cycle arrest in response to pheromone relationship: happens_during GO:0000080 ! mitotic G1 phase relationship: inheres_in GO:0000751 ! mitotic cell cycle arrest in response to pheromone created_by: midori creation_date: 2014-11-27T14:28:30Z [Term] id: FYPO:0004075 name: decreased cell growth def: "A cellular process phenotype in which cell growth is decreased. Cell growth is the irreversible increase in size over time by accretion and biosynthetic production of matter similar to that already present." [PomBase:mah] comment: Note that this term refers to growth, i.e. increase in size, of an individual cell. If you have measured the rate or extent of growth of a culture in liquid medium or on plates, use one of the 'cell population growth' terms. synonym: "reduced cell growth" EXACT [PomBase:mah] is_a: FYPO:0002862 ! abnormal cell growth is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0016049 ! cell growth relationship: inheres_in GO:0016049 ! cell growth created_by: midori creation_date: 2014-11-27T14:34:56Z [Term] id: FYPO:0004076 name: inviable after spore germination, single or double cell division, elongated multiseptate cell def: "A phenotype in which a spore germinates to produce a cell that is longer than normal, has more than one septum, and undergoes one or two rounds of cell division." [PomBase:mah] synonym: "essential; germinating spore, single or double cell division, elongated multiseptate cell" RELATED [PomBase:mah] synonym: "inviable following spore germination, single or double cell division, elongated multiseptate cell" EXACT [PomBase:mah] synonym: "inviable germinated spore, single or double cell division, elongated multiseptate cell" EXACT [PomBase:mah] is_a: FYPO:0002724 ! inviable after spore germination, single or double cell division, elongated cell created_by: midori creation_date: 2014-11-27T14:47:33Z [Term] id: FYPO:0004077 name: abnormal sporulation resulting in formation of ascus with single large spore def: "A sporulation phenotype that results in the formation of an ascus that contains a single spore that is larger than normal." [PMID:15331764, PomBase:mah, PomBase:vw] synonym: "abnormal ascospore formation resulting in formation of ascus with single large spore" EXACT [GO:0030437, PomBase:mah] synonym: "abnormal sporulation resulting in formation of single-spored asci" EXACT [PomBase:mah] is_a: FYPO:0003066 ! abnormal sporulation resulting in formation of ascus with fewer than four spores created_by: midori creation_date: 2014-11-27T14:57:32Z [Term] id: FYPO:0004078 name: normal growth on cyclosporin A def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing cyclosporin A." [PomBase:mah] synonym: "normal cell population growth in presence of cyclosporin A" EXACT [PomBase:mah] synonym: "normal cell population growth on cyclosporin A" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to cyclosporin A" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on cyclosporin A" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:4031 ! cyclosporin A relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:4031 ! cyclosporin A created_by: midori creation_date: 2014-11-27T15:00:41Z [Term] id: FYPO:0004079 name: normal histone H3-S10 phosphorylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which phosphorylation of serine at position 10 of histone H3 is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal histone H3 phosphorylation at S10" EXACT [GO:0043987] synonym: "normal histone H3-S10 phosphorylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal histone H3-S10 phosphorylation during vegetative growth" EXACT [PomBase:mah] synonym: "normal histone H3S10 phosphorylation" EXACT [GO:0043987] is_a: FYPO:0002595 ! normal histone phosphorylation is_a: FYPO:0003645 ! normal protein serine phosphorylation during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0043987 ! histone H3-S10 phosphorylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0043987 ! histone H3-S10 phosphorylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-11-27T15:02:21Z [Term] id: FYPO:0004080 name: increased histone H3-S10 phosphorylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which phosphorylation of serine at position 10 of histone H3 is increased." [PomBase:mah] synonym: "increased histone H3 phosphorylation at S10" EXACT [GO:0043987] synonym: "increased histone H3-S10 phosphorylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H3-S10 phosphorylation during vegetative growth" EXACT [PomBase:mah] synonym: "increased histone H3S10 phosphorylation" EXACT [GO:0043987] is_a: FYPO:0002594 ! increased histone phosphorylation is_a: FYPO:0004420 ! increased protein serine phosphorylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0043987 ! histone H3-S10 phosphorylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0043987 ! histone H3-S10 phosphorylation created_by: midori creation_date: 2014-11-27T15:05:52Z [Term] id: FYPO:0004081 name: decreased protein localization to chromatin at tRNA genes def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to chromatin at tRNA genes is decreased." [PMID:24945319, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to chromatin at tRNA genes" EXACT [PomBase:mah] synonym: "decreased protein localization to chromatin at transfer RNA genes" EXACT [PomBase:mah] synonym: "decreased protein localization to chromatin at tRNA genes during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to chromatin at tRNA genes during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to chromatin at tRNA genes" EXACT [PomBase:mah] is_a: FYPO:0004346 ! decreased protein localization to chromatin at ncRNA genes intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071168 ! protein localization to chromatin intersection_of: occurs_at SO:0001272 ! tRNA_gene relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071168 ! protein localization to chromatin relationship: occurs_at SO:0001272 ! tRNA_gene created_by: midori creation_date: 2014-11-27T15:06:59Z [Term] id: FYPO:0004082 name: normal protein phosphorylation during mitosis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins is normal (i.e. indistinguishable from wild type) during mitosis." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein phosphorylation during mitosis during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein phosphorylation during mitotic M phase" RELATED [PomBase:mah] synonym: "normal protein phosphorylation during mitotic nuclear division" EXACT [GO:0007067] is_a: FYPO:0000776 ! normal protein phosphorylation during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0007067 ! mitotic nuclear division intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0007067 ! mitotic nuclear division relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-11-27T15:08:39Z [Term] id: FYPO:0004083 name: normal protein level def: "A cell phenotype in which the amount of protein measured in a cell is normal (i.e. indistinguishable from wild type). Total protein or a specific protein may be affected." [PomBase:mah] subset: qc_do_not_manually_annotate synonym: "protein/peptide accumulation: normal" RELATED [SGD:phenotype_annotation] is_a: FYPO:0001076 ! normal level of substance in cell intersection_of: PATO:0001159 ! concentrated intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:36080 ! protein relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2014-11-27T15:14:06Z [Term] id: FYPO:0004084 name: normal protein level during nitrogen starvation def: "A cell phenotype in which the amount of protein measured in a cell that is subject to nitrogen starvation is normal (i.e. indistinguishable from wild type). Total protein or a specific protein may be affected." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal cellular protein level during nitrogen starvation" EXACT [PomBase:mah] synonym: "normal protein accumulation during nitrogen starvation" RELATED [PomBase:mah] synonym: "normal protein level during nitrogen depletion" EXACT [PomBase:vw] synonym: "normal protein level during nitrogen deprivation" EXACT [PomBase:vw] is_a: FYPO:0004083 ! normal protein level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2014-11-27T15:15:19Z [Term] id: FYPO:0004085 name: decreased vegetative cell growth def: "A cellular process phenotype in which cell growth is decreased during the vegetative growth phase of the life cycle. Cell growth is the irreversible increase in size over time by accretion and biosynthetic production of matter similar to that already present." [PomBase:mah] comment: Note that this term refers to growth, i.e. increase in size, of an individual cell. If you have measured the rate or extent of growth of a culture in liquid medium or on plates, use one of the 'cell population growth' terms. synonym: "reduced vegetative cell growth" EXACT [PomBase:mah] is_a: FYPO:0003154 ! abnormal vegetative cell growth is_a: FYPO:0004075 ! decreased cell growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0016049 ! cell growth relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0016049 ! cell growth created_by: midori creation_date: 2014-12-02T11:05:31Z [Term] id: FYPO:0004086 name: abnormal meiotic centromere clustering def: "A cellular process phenotype in which centromere clustering is abnormal during one or both meiotic nuclear divisions. Centromeres are normally located in one or two clusters away from the spindle pole body during meiosis." [PomBase:mah] synonym: "abnormal centromere clustering during meiosis" EXACT [GO:1990571] synonym: "increased unclustered centromeres during meiosis" RELATED [PomBase:vw] is_a: FYPO:0000641 ! abnormal chromosome organization is_a: FYPO:0001440 ! abnormal protein complex localization is_a: FYPO:0002739 ! abnormal meiotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:1990571 ! meiotic centromere clustering intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:1990571 ! meiotic centromere clustering relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-12-02T12:59:48Z [Term] id: FYPO:0004087 name: increased number of cells with astral spindle microtubules def: "A cell population phenotype in which astral microtubules are present in a greater than normal proportion of the cells that have mitotic spindles." [PMID:11694582, PomBase:mah] synonym: "increased fraction of cells with spindles with astral microtubules" EXACT [PomBase:mah] synonym: "increased fraction of spindles with astral microtubules" EXACT [PomBase:vw] synonym: "increased number of cells with spindles with astral microtubules" EXACT [PomBase:mah] synonym: "increased number of spindles with astral microtubules" EXACT [PomBase:mah] is_a: FYPO:0000003 ! cell population phenotype is_a: FYPO:0001985 ! abnormal phenotype created_by: midori creation_date: 2014-12-02T13:21:54Z [Term] id: FYPO:0004088 name: abnormal cytoplasmic microtubules def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the morphology of cytoplasmic microtubules is abnormal." [PomBase:mah] synonym: "abnormal cytoplasmic microtubule morphology" EXACT [PomBase:al] synonym: "abnormal cytoplasmic microtubule structure" NARROW [PomBase:mah] synonym: "abnormal cytoplasmic microtubules during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal cytoplasmic microtubules during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0004315 ! abnormal microtubule cytoskeleton during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005881 ! cytoplasmic microtubule intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005881 ! cytoplasmic microtubule relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-12-02T13:36:42Z [Term] id: FYPO:0004089 name: decreased meiotic recombination during zygotic meiosis def: "A cellular process phenotype in which the occurrence of meiotic recombination is decreased during a zygotic meiotic nuclear division. Zygotic meiosis takes place immediately after conjugation and karyogamy, without intervening vegetative growth and division of diploid cells." [PMID:11907273, PomBase:mah] synonym: "decreased meiotic recombination in zygotic nucleus" EXACT [PomBase:vw] synonym: "reduced meiotic recombination during zygotic meiosis" EXACT [PomBase:mah] is_a: FYPO:0000485 ! decreased meiotic recombination created_by: midori creation_date: 2014-12-02T13:46:23Z [Term] id: FYPO:0004090 name: abnormal protein localization to microtubule cytoskeleton def: "A cell phenotype in which the localization of a protein to the microtubule cytoskeleton is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found associated with the microtubule cytoskeleton and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to microtubule cytoskeleton" EXACT [PomBase:mah] is_a: FYPO:0001370 ! abnormal protein localization intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0072698 ! protein localization to microtubule cytoskeleton intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0072698 ! protein localization to microtubule cytoskeleton relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2012-04-02T03:52:49Z [Term] id: FYPO:0004091 name: abolished protein localization to microtubule cytoskeleton def: "A cell phenotype in which the localization of a protein to the microtubule cytoskeleton is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to microtubule cytoskeleton" EXACT [PomBase:mah] synonym: "protein localization to microtubule cytoskeleton abolished" EXACT [PomBase:mah] is_a: FYPO:0001375 ! protein localization abolished is_a: FYPO:0004090 ! abnormal protein localization to microtubule cytoskeleton intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0072698 ! protein localization to microtubule cytoskeleton relationship: towards GO:0072698 ! protein localization to microtubule cytoskeleton created_by: midori creation_date: 2014-12-02T14:06:34Z [Term] id: FYPO:0004092 name: abolished protein localization to horsetail-astral microtubule array def: "A cell phenotype in which the localization of a protein to the horsetail-astral microtubule array is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to horsetail-astral microtubule array" EXACT [PomBase:mah] synonym: "protein localization to horsetail-astral microtubule array abolished" EXACT [PomBase:mah] is_a: FYPO:0004266 ! abolished protein localization to cortical microtubule cytoskeleton intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:1903696 ! protein localization to horsetail-astral microtubule array relationship: towards GO:1903696 ! protein localization to horsetail-astral microtubule array created_by: midori creation_date: 2014-12-02T14:25:33Z [Term] id: FYPO:0004093 name: normal meiotic telomere clustering def: "A meiosis phenotype in which meiotic telomere clustering is normal (i.e. indistinguishable from wild type). Meiotic telomere clustering is the dynamic reorganization of telomeres in early meiotic prophase, during which meiotic chromosome ends are gathered in a bouquet arrangement at the inner surface of the nuclear envelope proximal to the spindle pole body." [GO:0045141, PomBase:mah] is_a: FYPO:0000138 ! localization phenotype is_a: FYPO:0000627 ! normal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0045141 ! meiotic telomere clustering intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0045141 ! meiotic telomere clustering relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-12-02T14:35:49Z [Term] id: FYPO:0004094 name: abnormal protein localization during meiotic cell cycle def: "A cell phenotype that affects the localization of a protein in a cell during the meiotic cell cycle. A protein may be observed in a place where it is not normally found, absent from a place where it is normally found, or both." [PomBase:mah] comment: We recommend using one of the more specific terms instead of annotating to this term directly, if possible. If this term is used, we recommend noting which protein(s) were used in the assay. synonym: "abnormal cellular protein localisation during meiotic cell cycle" EXACT [PomBase:mah] synonym: "abnormal cellular protein localization during meiotic cell cycle" EXACT [PomBase:mah] synonym: "abnormal protein localisation during meiotic cell cycle" EXACT [PomBase:mah] is_a: FYPO:0001370 ! abnormal protein localization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0051321 ! meiotic cell cycle intersection_of: inheres_in_part_of GO:0034613 ! cellular protein localization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0051321 ! meiotic cell cycle relationship: inheres_in_part_of GO:0034613 ! cellular protein localization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-12-02T14:37:50Z [Term] id: FYPO:0004095 name: normal protein localization during meiotic cell cycle def: "A cell phenotype in which the localization of a protein in a cell is normal (i.e. indistinguishable from wild type) during the meiotic cell cycle." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation during meiotic cell cycle" EXACT [PomBase:mah] is_a: FYPO:0003627 ! normal protein localization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0051321 ! meiotic cell cycle intersection_of: inheres_in GO:0034613 ! cellular protein localization intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0051321 ! meiotic cell cycle relationship: inheres_in GO:0034613 ! cellular protein localization relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-12-02T14:39:40Z [Term] id: FYPO:0004096 name: normal protein localization to cytoskeleton def: "A cell phenotype in which the localization of a protein to the cytoskeleton is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to cytoskeleton" EXACT [PomBase:mah] is_a: FYPO:0003627 ! normal protein localization intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0044380 ! protein localization to cytoskeleton intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0044380 ! protein localization to cytoskeleton relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-12-02T14:43:36Z [Term] id: FYPO:0004097 name: normal actomyosin contractile ring contraction def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which actomyosin contractile ring contraction is normal (i.e. indistinguishable from wild type). Contractile ring contraction is the part of cytokinesis in which the actomyosin contractile ring constricts." [GO:1902404, PomBase:mah] synonym: "normal actomyosin contractile ring constriction" EXACT [PomBase:vw] synonym: "normal actomyosin contractile ring contraction during vegetative growth" EXACT [PomBase:mah] synonym: "normal contractile ring contraction" EXACT [PomBase:vw] synonym: "normal cytokinetic contractile ring contraction" EXACT [PomBase:vw] synonym: "normal mitotic actomyosin contractile ring contraction" EXACT [GO:1902404, PomBase:mah] synonym: "normal mitotic contractile ring contraction" EXACT [PomBase:vw] is_a: FYPO:0002741 ! normal mitotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902404 ! mitotic actomyosin contractile ring contraction intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902404 ! mitotic actomyosin contractile ring contraction relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-12-02T15:24:02Z [Term] id: FYPO:0004098 name: incomplete mitotic sister chromatid segregation, with phi-shaped DNA mass def: "A cellular process phenotype in which mitotic sister chromatid segregation stops before completing separation of chromosomes, and most of the DNA remains in a single mass at or near the midpoint of the mitotic spindle, but portions of the chromosomes can separate along the spindle, resulting in the formation of a DNA mass shaped like the Greek letter phi." [PMID:12455694, PomBase:mah] synonym: "incomplete mitotic sister chromatid segregation, with phi-shaped DNA mass, during vegetative growth" EXACT [PomBase:mah] synonym: "incomplete mitotic sister chromatid separation, with phi-shaped DNA mass" RELATED [PomBase:mah] is_a: FYPO:0003757 ! incomplete mitotic sister chromatid segregation created_by: midori creation_date: 2014-12-02T15:25:35Z [Term] id: FYPO:0004099 name: normal mitotic chromosome condensation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitotic chromosome condensation is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal mitotic chromosome condensation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001346 ! DNA metabolism phenotype during vegetative growth is_a: FYPO:0002741 ! normal mitotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0007076 ! mitotic chromosome condensation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0007076 ! mitotic chromosome condensation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-12-02T15:27:37Z [Term] id: FYPO:0004100 name: inviable after spore germination, without cell division, elongated cell with abnormal nuclear morphology def: "A phenotype in which a spore germinates to produce an inviable cell that does not divide, is longer than normal, and contains a nucleus with abnormal morphology." [PMID:7957061, PomBase:mah] comment: Abnormal chromosome morphology is usually inferred from the abnormal nuclear morphology observed in this phenotype. synonym: "essential; germinating spore, without cell division, elongated cell with abnormal chromosome morphology" RELATED [PomBase:mah] synonym: "inviable following spore germination, without cell division, elongated cell with abnormal chromosome morphology" EXACT [PomBase:mah] synonym: "inviable germinated spore, without cell division, elongated cell with abnormal chromosome morphology" EXACT [PomBase:mah] is_a: FYPO:0004603 ! inviable after spore germination, without cell division, elongated cell created_by: midori creation_date: 2014-12-02T15:32:33Z [Term] id: FYPO:0004101 name: lagging mitotic chromosomes, with complete sister chromatid separation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which sister chromatids do not move towards the spindle poles at the same time during mitosis prior to completion of chromosome segregation. Although one or more chromosomes remain distant from the spindle pole after the bulk of the DNA has separated, mitotic sister chromatid segregation does eventually go on to complete separation of chromosomes." [PMID:17561805, PomBase:mah] comment: Consider also annotating to 'unequal mitotic sister chromatid segregation' (FYPO:0003241) or one of its descendants, because chromosomes that lag at anaphase are often missegregated at telophase. synonym: "chromosome segregation defects, lagging mitotic chromosomes, with complete sister chromatid separation" EXACT [PomBase:mah] synonym: "lagging chromosomes, with complete sister chromatid separation, during vegetative growth" EXACT [PomBase:mah] synonym: "lagging mitotic chromosomes, with complete chromosome separation" EXACT [PomBase:mah] synonym: "lagging mitotic sister chromatids, with complete sister chromatid separation" EXACT [PomBase:mah] is_a: FYPO:0000228 ! lagging mitotic chromosomes created_by: midori creation_date: 2014-12-02T15:38:56Z [Term] id: FYPO:0004102 name: decreased protein polyubiquitination def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of polyubiquitination of one or more specific proteins, or of specific protein sites, is decreased." [PomBase:mah] synonym: "decreased protein multiubiquitination" EXACT [PomBase:vw] synonym: "decreased protein polyubiquitination during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein polyubiquitination during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein polyubiquitinylation" EXACT [GO:0000209, PomBase:mah] synonym: "decreased protein polyubiquitylation" EXACT [GO:0000209, PomBase:mah] synonym: "reduced protein polyubiquitination" EXACT [PomBase:mah] is_a: FYPO:0002768 ! decreased protein ubiquitination intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000209 ! protein polyubiquitination relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000209 ! protein polyubiquitination created_by: midori creation_date: 2014-12-02T15:45:22Z [Term] id: FYPO:0004103 name: viable spherical vegetative cell def: "A cell morphology phenotype in which a vegetatively growing cell is viable, and shaped in the form of a sphere." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "spherical viable cell" EXACT [PomBase:mah] synonym: "viable spherical cell" EXACT [PomBase:mah] synonym: "viable spherical cell during vegetative growth" EXACT [PomBase:mah] synonym: "viable spherical vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0002380 ! viable spheroid vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000129 ! spherical vegetative cell intersection_of: has_part FYPO:0001491 ! viable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000129 ! spherical vegetative cell relationship: has_part FYPO:0001491 ! viable vegetative cell created_by: midori creation_date: 2014-12-02T15:47:54Z [Term] id: FYPO:0004104 name: inviable spherical vegetative cell def: "A cell morphology phenotype in which a vegetatively growing cell is inviable, and shaped in the form of a sphere." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "inviable spherical cell" EXACT [PomBase:mah] synonym: "inviable spherical cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable spherical vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "spherical inviable cell" EXACT [PomBase:mah] is_a: FYPO:0002482 ! inviable spheroid vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000129 ! spherical vegetative cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000129 ! spherical vegetative cell relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2014-12-02T15:48:31Z [Term] id: FYPO:0004105 name: abolished polar cell growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which polar cell growth does not occur. Cells grow without polarization, instead of growing only at the ends." [PMID:8187760, PomBase:mah] synonym: "abolished polar vegetative cell growth" EXACT [PomBase:mah] synonym: "abolished polarized cell growth" EXACT [PomBase:mah] synonym: "abolished unidimensional cell growth" EXACT [PomBase:mah] synonym: "depolarized cell growth" EXACT [PomBase:mah] is_a: FYPO:0003154 ! abnormal vegetative cell growth is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0009826 ! unidimensional cell growth relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0009826 ! unidimensional cell growth created_by: midori creation_date: 2014-12-02T15:50:35Z [Term] id: FYPO:0004106 name: inviable multinucleate aseptate vegetative cell def: "A cell morphology phenotype in which a vegetative cell is inviable, has no septum, and contains more than one nucleus." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "essential; multinucleate inviable vegetative cell" RELATED [PomBase:mah] synonym: "inviable multinucleate aseptate cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable multinucleate aseptate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "multinucleate aseptate inviable vegetative cell" EXACT [PomBase:mah] is_a: FYPO:0003931 ! inviable aseptate vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000061 ! multinucleate vegetative cell intersection_of: has_part FYPO:0000949 ! aseptate intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000061 ! multinucleate vegetative cell relationship: has_part FYPO:0000949 ! aseptate relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2014-12-02T16:29:48Z [Term] id: FYPO:0004107 name: normal protein level during mitotic G2 phase def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during G2 phase of the mitotic cell cycle is normal (i.e. indistinguishable from wild type). Total protein or a specific protein may be affected." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein accumulation during mitotic G2 phase" RELATED [PomBase:mah] synonym: "normal protein level during G2 phase of mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein level during mitotic G2 phase during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000833 ! normal protein level during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0000085 ! mitotic G2 phase intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0000085 ! mitotic G2 phase relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2014-12-02T16:32:23Z [Term] id: FYPO:0004108 name: increased protein level during mitotic G1 phase def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during G1 phase of the mitotic cell cycle is higher than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein accumulation during mitotic G1 phase" RELATED [PomBase:mah] synonym: "increased protein level during G1 phase of mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein level during mitotic G1 phase during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001327 ! increased protein level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0000080 ! mitotic G1 phase intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0000080 ! mitotic G1 phase relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2014-12-02T16:35:52Z [Term] id: FYPO:0004109 name: delayed activation of monopolar cell growth def: "A regulation phenotype observed in the vegetative growth phase of the life cycle in which the activation of monopolar cell growth, i.e. the initiation of growth at the old end of a cell following cell division, begins later than normal." [PomBase:mah] synonym: "delayed activation of monopolar vegetative cell growth" EXACT [PomBase:mah] is_a: FYPO:0001393 ! abnormal activation of monopolar cell growth is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051522 ! activation of monopolar cell growth relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051522 ! activation of monopolar cell growth created_by: midori creation_date: 2014-12-02T16:37:34Z [Term] id: FYPO:0004110 name: normal protein level during exit from mitosis def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during exit from mitosis is normal (i.e. indistinguishable from wild type). Total protein or a specific protein may be affected." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein accumulation during exit from mitosis" RELATED [PomBase:mah] synonym: "normal protein level during exit from mitosis during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein level during mitosis to G1 transition" EXACT [PomBase:vw] synonym: "normal protein level during mitotic exit" EXACT [PomBase:mah] is_a: FYPO:0000833 ! normal protein level during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0010458 ! exit from mitosis intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0010458 ! exit from mitosis relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2014-12-02T16:49:01Z [Term] id: FYPO:0004111 name: decreased protein phosphorylation during mitotic G2 phase def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal during G2 phase of the mitotic cell cycle." [PomBase:mah] synonym: "decreased protein phosphorylation during mitotic G2 phase during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein phosphorylation during mitotic G2-phase" EXACT [PomBase:vw] synonym: "decreased protein/peptide phosphorylation during mitotic G2 phase" EXACT [PomBase:mah] synonym: "reduced protein phosphorylation during mitotic G2 phase" EXACT [PomBase:mah] is_a: FYPO:0001838 ! decreased protein phosphorylation during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0000085 ! mitotic G2 phase intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0000085 ! mitotic G2 phase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2014-12-03T11:21:10Z [Term] id: FYPO:0004112 name: increased protein phosphorylation during mitotic G2 phase def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a greater extent than normal during G2 phase of the mitotic cell cycle." [PomBase:mah] synonym: "increased protein phosphorylation during mitotic G2 phase during vegetative growth" EXACT [PomBase:mah] synonym: "increased protein phosphorylation during mitotic G2-phase" EXACT [PomBase:vw] synonym: "increased protein/peptide phosphorylation during mitotic G2 phase" EXACT [PomBase:mah] is_a: FYPO:0001038 ! increased protein phosphorylation during vegetative growth intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0000085 ! mitotic G2 phase intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0000085 ! mitotic G2 phase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2014-12-03T11:22:02Z [Term] id: FYPO:0004113 name: inviable after spore germination, without cell division, small cell def: "A phenotype in which a spore germinates to produce an inviable cell that does not divide, and that is smaller than normal." [PomBase:mah] synonym: "essential; germinating spore, without cell division, small cell" RELATED [PomBase:mah] synonym: "inviable after spore germination, undivided small cell" EXACT [PomBase:mah] synonym: "inviable following spore germination, without cell division, small cell" EXACT [PomBase:mah] synonym: "inviable germinated spore, without cell division, small cell" EXACT [PomBase:mah] is_a: FYPO:0001991 ! inviable after spore germination, without cell division created_by: midori creation_date: 2014-12-03T11:24:29Z [Term] id: FYPO:0004114 name: inviable after spore germination, without cell division, abnormal septum morphology def: "A phenotype in which a spore germinates to produce an inviable cell that does not divide, and that has a septum with abnormal size, shape, or structure." [PMID:15116432, PomBase:mah] synonym: "essential; germinating spore, without cell division, abnormal septum morphology" RELATED [PomBase:mah] synonym: "inviable after spore germination, undivided cell, abnormal septum morphology" EXACT [PomBase:mah] synonym: "inviable after spore germination, without cell division, abnormal septum formation" EXACT [PomBase:mah] synonym: "inviable following spore germination, without cell division, abnormal septum morphology" EXACT [PomBase:mah] synonym: "inviable germinated spore, without cell division, abnormal septum morphology" EXACT [PomBase:mah] is_a: FYPO:0001991 ! inviable after spore germination, without cell division created_by: midori creation_date: 2014-12-03T11:49:43Z [Term] id: FYPO:0004115 name: inviable after spore germination, without cell division, abnormal septum morphology, enlarged nucleus def: "A phenotype in which a spore germinates to produce an inviable cell that does not divide, and that has a septum with abnormal size, shape, or structure and a nucleus that is larger than normal." [PMID:15116432, PomBase:mah] synonym: "essential; germinating spore, without cell division, abnormal septum morphology, enlarged nucleus" RELATED [PomBase:mah] synonym: "inviable after spore germination, undivided cell, abnormal septum morphology, enlarged nucleus" EXACT [PomBase:mah] synonym: "inviable after spore germination, without cell division, abnormal septum formation" EXACT [PomBase:mah] synonym: "inviable following spore germination, without cell division, abnormal septum morphology, enlarged nucleus" EXACT [PomBase:mah] synonym: "inviable germinated spore, without cell division, abnormal septum morphology, enlarged nucleus" EXACT [PomBase:mah] is_a: FYPO:0004114 ! inviable after spore germination, without cell division, abnormal septum morphology created_by: midori creation_date: 2014-12-03T11:52:09Z [Term] id: FYPO:0004116 name: inviable after spore germination, without cell division, cell enlarged around nucleus def: "A phenotype in which a spore germinates to produce an inviable cell that does not divide, and that has a diameter larger than normal only near the middle of the cell, around the nucleus." [PMID:15116432, PomBase:mah] synonym: "essential; germinating spore, without cell division, cell enlarged around nucleus" RELATED [PomBase:mah] synonym: "inviable after spore germination, undivided cell, cell enlarged around nucleus" EXACT [PomBase:mah] synonym: "inviable after spore germination, without cell division, cell enlarged around nucleus" EXACT [PomBase:mah] synonym: "inviable following spore germination, without cell division, cell enlarged around nucleus" EXACT [PomBase:mah] synonym: "inviable germinated spore, without cell division, cell enlarged around nucleus" EXACT [PomBase:mah] is_a: FYPO:0001991 ! inviable after spore germination, without cell division created_by: midori creation_date: 2014-12-03T11:53:10Z [Term] id: FYPO:0004117 name: inviable after spore germination, without cell division, normal septum morphology def: "A phenotype in which a spore germinates to produce an inviable cell that does not divide, and that has a septum with normal size, shape, or structure." [PMID:15116432, PomBase:mah] synonym: "essential; germinating spore, without cell division, normal septum morphology" RELATED [PomBase:mah] synonym: "inviable after spore germination, undivided cell, normal septum morphology" EXACT [PomBase:mah] synonym: "inviable after spore germination, without cell division, normal septum formation" EXACT [PomBase:mah] synonym: "inviable following spore germination, without cell division, normal septum morphology" EXACT [PomBase:mah] synonym: "inviable germinated spore, without cell division, normal septum morphology" EXACT [PomBase:mah] is_a: FYPO:0001991 ! inviable after spore germination, without cell division created_by: midori creation_date: 2014-12-03T11:55:19Z [Term] id: FYPO:0004118 name: inviable after spore germination, multiple cell divisions, normal septum morphology def: "A phenotype in which a spore germinates to produce an inviable cell that has one or more septa with normal size, shape, or structure, and that undergoes two or more rounds of cell division, and then dies." [PMID:15116432, PomBase:mah] synonym: "essential; germinating spore, multiple cell divisions, normal septum morphology" RELATED [PomBase:mah] synonym: "inviable after spore germination, multiple cell divisions, normal septum morphology" EXACT [PomBase:mah] synonym: "inviable following spore germination, multiple cell divisions, normal septum morphology" EXACT [PomBase:mah] synonym: "inviable germinated spore, multiple cell divisions, normal septum morphology" EXACT [PomBase:mah] is_a: FYPO:0002430 ! inviable after spore germination, multiple cell divisions created_by: midori creation_date: 2014-12-03T11:56:13Z [Term] id: FYPO:0004119 name: inviable after spore germination, multiple cell divisions, elongated multinucleate cell with abnormal septum morphology def: "A phenotype in which a spore germinates to produce an inviable cell that is longer than normal, has more than one nucleus, has one or more septa with abnormal size, shape, or structure, and that undergoes two or more rounds of cell division, and then dies." [PMID:15116432, PomBase:mah] synonym: "essential; germinating spore, multiple cell divisions, elongated multinucleate cell with abnormal septum morphology" RELATED [PomBase:mah] synonym: "inviable after spore germination, multiple cell divisions, elongated multinucleate cell with abnormal septum morphology" EXACT [PomBase:mah] synonym: "inviable following spore germination, multiple cell divisions, elongated multinucleate cell with abnormal septum morphology" EXACT [PomBase:mah] synonym: "inviable germinated spore, multiple cell divisions, elongated multinucleate cell with abnormal septum formation" EXACT [PomBase:mah] is_a: FYPO:0002262 ! inviable after spore germination, multiple cell divisions, elongated cell created_by: midori creation_date: 2014-12-03T11:57:40Z [Term] id: FYPO:0004120 name: inviable after spore germination, multiple cell divisions, small cell with abnormal septum morphology def: "A phenotype in which a spore germinates to produce an inviable cell that is smaller than normal, has a septum with abnormal size, shape, or structure, and that undergoes two or more rounds of cell division, and then dies." [PMID:15116432, PomBase:mah] synonym: "essential; germinating spore, multiple cell divisions, small cell with abnormal septum morphology" RELATED [PomBase:mah] synonym: "inviable after spore germination, multiple cell divisions, small cell with abnormal septum formation" EXACT [PomBase:mah] synonym: "inviable following spore germination, multiple cell divisions, small cell with abnormal septum morphology" EXACT [PomBase:mah] synonym: "inviable germinated spore, multiple cell divisions, small cell with abnormal septum morphology" EXACT [PomBase:mah] is_a: FYPO:0002262 ! inviable after spore germination, multiple cell divisions, elongated cell created_by: midori creation_date: 2014-12-03T12:01:11Z [Term] id: FYPO:0004121 name: normal protein import into nucleus def: "A transport phenotype observed in the vegetative growth phase of the life cycle in which the import of protein into the nucleus is normal (i.e. indistinguishable from wild type). Import of all proteins or a specific protein may be assayed." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein import into nucleus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein import into nucleus during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000516 ! normal nuclear import is_a: FYPO:0000838 ! normal protein localization to nucleus intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006606 ! protein import into nucleus intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006606 ! protein import into nucleus relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-12-03T12:12:16Z [Term] id: FYPO:0004122 name: cut during cellular response to thiabendazole def: "A cut phenotype that is observed when a cell is exposed to thiabendazole. In a cut phenotype, a cell undergoes septation despite abnormal chromosome segregation, such that the septum physically divides the nucleus into two parts, and produces inviable daughter cells." [PomBase:mah] synonym: "cut during cellular response to TBZ" EXACT [CHEBI:45979, PomBase:mah] synonym: "cut during cellular response to thiabendazole during mitotic cell cycle" RELATED [PomBase:mah] synonym: "cut during cellular response to thiabendazole during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003165 ! cut intersection_of: FYPO:0003165 ! cut intersection_of: during GO:0072713 ! cellular response to thiabendazole relationship: during GO:0072713 ! cellular response to thiabendazole created_by: midori creation_date: 2014-12-03T12:13:31Z [Term] id: FYPO:0004123 name: normal glutathione disulfide oxidoreductase activity def: "A molecular function phenotype in which the observed rate of a glutathione disulfide oxidoreductase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0015038 ! glutathione disulfide oxidoreductase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0015038 ! glutathione disulfide oxidoreductase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-12-03T12:26:59Z [Term] id: FYPO:0004124 name: decreased protein level during cellular response to cadmium ion def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during a cellular response to cadmium ions is lower than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein accumulation during cellular response to cadmium ion" RELATED [PomBase:mah] synonym: "decreased protein level during cellular response to cadmium" EXACT [PomBase:mah] synonym: "decreased protein level during cellular response to cadmium ion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein level during cellular response to cadmium ion during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein level during cellular response to cadmium ion" EXACT [PomBase:mah] is_a: FYPO:0001324 ! decreased protein level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0071276 ! cellular response to cadmium ion intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0071276 ! cellular response to cadmium ion relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2014-12-03T12:30:14Z [Term] id: FYPO:0004125 name: abolished histone H3-K4 dimethylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which dimethylation of lysine at position 4 of histone H3 does not occur." [PomBase:mah] synonym: "abolished histone H3 K4 dimethylation" EXACT [GO:0044648, PomBase:mah] synonym: "abolished histone H3-K4 dimethylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished histone H3-K4 dimethylation during vegetative growth" EXACT [PomBase:mah] synonym: "abolished histone H3K4me2" EXACT [PomBase:mah] synonym: "abolished histone lysine H3 K4 dimethylation" EXACT [GO:0044648, PomBase:mah] synonym: "histone H3-K4 dimethylation abolished" EXACT [PomBase:mah] synonym: "histone H3-K4 dimethylation absent" EXACT [PomBase:mah] is_a: FYPO:0002917 ! abolished histone H3-K4 methylation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0044648 ! histone H3-K4 dimethylation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0044648 ! histone H3-K4 dimethylation created_by: midori creation_date: 2014-12-03T12:35:34Z [Term] id: FYPO:0004126 name: abolished histone H3-K4 trimethylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which trimethylation of lysine at position 4 of histone H3 does not occur." [PomBase:mah] synonym: "abolished histone H3 K4 trimethylation" EXACT [PomBase:mah] synonym: "abolished histone H3-K4 trimethylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished histone H3-K4 trimethylation during vegetative growth" EXACT [PomBase:mah] synonym: "abolished histone H3K4me3" EXACT [PomBase:mah] synonym: "abolished histone lysine H3 K4 trimethylation" EXACT [PomBase:mah] synonym: "histone H3-K4 trimethylation abolished" EXACT [PomBase:mah] synonym: "histone H3-K4 trimethylation absent" EXACT [PomBase:mah] is_a: FYPO:0002917 ! abolished histone H3-K4 methylation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0080182 ! histone H3-K4 trimethylation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0080182 ! histone H3-K4 trimethylation created_by: midori creation_date: 2014-12-03T12:37:05Z [Term] id: FYPO:0004127 name: decreased histone H3-K4 dimethylation at protein coding gene def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the dimethylation of lysine at position 4 of histone H3 at protein-coding genes occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased histone H3 K4 dimethylation at protein coding gene" EXACT [GO:0044648, PomBase:mah] synonym: "decreased histone H3-K4 dimethylation at protein coding gene during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H3-K4 dimethylation at protein coding gene during vegetative growth" EXACT [PomBase:mah] synonym: "decreased histone H3K4 dimethylation at protein coding gene" EXACT [PomBase:vw] synonym: "decreased histone H3K4me2 at protein coding gene" EXACT [PomBase:mah] synonym: "decreased histone lysine H3 K4 dimethylation at protein coding gene" EXACT [GO:0044648, PomBase:mah] synonym: "reduced histone H3-K4 dimethylation at protein coding gene" EXACT [PomBase:mah] is_a: FYPO:0002330 ! abnormal histone H3-K4 methylation is_a: FYPO:0002367 ! decreased histone H3-K4 dimethylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0044648 ! histone H3-K4 dimethylation intersection_of: occurs_at SO:0001217 ! protein_coding_gene relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0044648 ! histone H3-K4 dimethylation relationship: occurs_at SO:0001217 ! protein_coding_gene created_by: midori creation_date: 2014-12-03T12:38:48Z [Term] id: FYPO:0004128 name: abnormal cysteine-type peptidase activity def: "A molecular function phenotype in which the observed rate of a cysteine-type peptidase activity is abnormal." [PomBase:mah] synonym: "abnormal cysteine protease activity" EXACT [PomBase:mah] is_a: FYPO:0000666 ! abnormal peptidase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004197 ! cysteine-type endopeptidase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004197 ! cysteine-type endopeptidase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-12-03T12:46:21Z [Term] id: FYPO:0004129 name: increased cysteine-type peptidase activity def: "A molecular function phenotype in which the observed rate of a cysteine-type peptidase activity is increased." [PomBase:mah] synonym: "increased cysteine protease activity" EXACT [PomBase:mah] is_a: FYPO:0000667 ! increased peptidase activity is_a: FYPO:0004128 ! abnormal cysteine-type peptidase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0004197 ! cysteine-type endopeptidase activity relationship: inheres_in GO:0004197 ! cysteine-type endopeptidase activity created_by: midori creation_date: 2014-12-03T12:46:36Z [Term] id: FYPO:0004130 name: decreased succinate dehydrogenase (ubiquinone) activity def: "A molecular function phenotype in which the observed rate of succinate dehydrogenase (ubiquinone) activity is decreased." [PomBase:mah] synonym: "reduced succinate dehydrogenase (ubiquinone) activity" EXACT [PomBase:mah] is_a: FYPO:0000690 ! decreased oxidoreductase activity is_a: FYPO:0003322 ! abnormal succinate dehydrogenase (ubiquinone) activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0008177 ! succinate dehydrogenase (ubiquinone) activity relationship: inheres_in GO:0008177 ! succinate dehydrogenase (ubiquinone) activity created_by: midori creation_date: 2014-12-09T11:35:33Z [Term] id: FYPO:0004131 name: increased succinate dehydrogenase (ubiquinone) activity def: "A molecular function phenotype in which the observed rate of succinate dehydrogenase (ubiquinone) activity is increased." [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0003322 ! abnormal succinate dehydrogenase (ubiquinone) activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0008177 ! succinate dehydrogenase (ubiquinone) activity relationship: inheres_in GO:0008177 ! succinate dehydrogenase (ubiquinone) activity created_by: midori creation_date: 2014-12-09T11:35:44Z [Term] id: FYPO:0004132 name: normal sulfite reductase activity def: "A molecular function phenotype in which the observed rate of sulfite reductase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal sulphite reductase activity" EXACT [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0016002 ! sulfite reductase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0016002 ! sulfite reductase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-12-09T11:43:30Z [Term] id: FYPO:0004133 name: normal reactive oxygen species level during nitrogen starvation def: "A cell phenotype in which the amount of reactive oxygen species (ROS) measured in a cell that is subject to nitrogen starvation is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cellular reactive oxygen species level during nitrogen starvation" EXACT [PomBase:mah] synonym: "normal reactive oxygen species level during nitrogen depletion" EXACT [PomBase:vw] synonym: "normal reactive oxygen species level during nitrogen deprivation" EXACT [PomBase:vw] synonym: "normal ROS accumulation during nitrogen starvation" RELATED [PomBase:mah] synonym: "normal ROS level during nitrogen starvation" EXACT [PomBase:mah] is_a: FYPO:0001076 ! normal level of substance in cell intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:26523 ! reactive oxygen species relationship: exists_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:26523 ! reactive oxygen species created_by: midori creation_date: 2014-12-09T11:47:25Z [Term] id: FYPO:0004134 name: decreased RNA level during cellular response to diethyl maleate def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to diethyl maleate is lower than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased mRNA level during cellular response to diethyl maleate" NARROW [PomBase:mah] synonym: "decreased RNA accumulation during cellular response to diethyl maleate" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to DEM" EXACT [PomBase:al] synonym: "decreased RNA level during cellular response to diethyl maleate during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to diethyl maleate during vegetative growth" EXACT [PomBase:mah] synonym: "decreased transcript level during cellular response to diethyl maleate" EXACT [PomBase:vw] synonym: "reduced RNA level during cellular response to diethyl maleate" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: exists_during GO:1902112 ! cellular response to diethyl maleate intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: exists_during GO:1902112 ! cellular response to diethyl maleate relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-12-09T11:52:45Z [Term] id: FYPO:0004135 name: resistance to copper def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of copper ions than normal." [PomBase:mah] synonym: "resistance to copper during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to copper during vegetative growth" EXACT [PomBase:mah] synonym: "resistance to copper ion" EXACT [PomBase:mah] synonym: "resistant to copper" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:23378 ! copper cation relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:23378 ! copper cation created_by: midori creation_date: 2014-12-09T11:56:58Z [Term] id: FYPO:0004136 name: abolished histone H3-K9 dimethylation at telomere def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which dimethylation of lysine at position 9 of histone H3 in telomeric regions does not occur." [PomBase:mah] synonym: "abolished histone H3 K9 dimethylation at telomere" EXACT [GO:0036123, PomBase:mah] synonym: "abolished histone H3-K9 dimethylation at telomere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished histone H3-K9 dimethylation at telomere during vegetative growth" EXACT [PomBase:mah] synonym: "abolished histone H3-K9 dimethylation at telomeric region" EXACT [PomBase:vw] synonym: "abolished histone H3K9me2 at telomere" EXACT [PomBase:mah] synonym: "abolished histone lysine H3 K9 dimethylation at telomere" EXACT [GO:0036123, PomBase:mah] synonym: "abolished telomeric histone H3-K9 dimethylation" EXACT [PomBase:mah] synonym: "histone H3-K9 dimethylation abolished at telomere" EXACT [PomBase:mah] synonym: "histone H3-K9 dimethylation absent at telomere" EXACT [PomBase:al] is_a: FYPO:0002820 ! abolished histone H3-K9 methylation at telomere intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: occurs_at SO:0000624 ! telomere intersection_of: towards GO:0036123 ! histone H3-K9 dimethylation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: occurs_at SO:0000624 ! telomere relationship: towards GO:0036123 ! histone H3-K9 dimethylation created_by: midori creation_date: 2014-12-09T11:58:04Z [Term] id: FYPO:0004137 name: decreased histone H3-K9 dimethylation at subtelomeric heterochromatin def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which dimethylation of lysine at position 9 of histone H3 in heterochromatin at subtelomeric regions occurs to a lower extent than normal." [PMID:25245948, PomBase:mah] synonym: "decreased histone H3 K9 dimethylation at subtelomeric heterochromatin" EXACT [GO:0036123, PomBase:mah] synonym: "decreased histone H3-K9 dimethylation at subtelomeres" EXACT [PomBase:al] synonym: "decreased histone H3-K9 dimethylation at subtelomeric heterochromatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H3-K9 dimethylation at subtelomeric heterochromatin during vegetative growth" EXACT [PomBase:mah] synonym: "decreased histone H3K9me2 at subtelomeric heterochromatin" EXACT [PomBase:mah] synonym: "decreased histone lysine H3 K9 dimethylation at subtelomeric heterochromatin" EXACT [GO:0036123, PomBase:mah] synonym: "reduced histone H3-K9 dimethylation at subtelomeric heterochromatin" EXACT [PomBase:mah] is_a: FYPO:0000876 ! decreased histone H3-K9 dimethylation is_a: FYPO:0003572 ! decreased histone H3-K9 methylation at subtelomeric heterochromatin intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0036123 ! histone H3-K9 dimethylation intersection_of: occurs_in GO:1990421 ! subtelomeric heterochromatin relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0036123 ! histone H3-K9 dimethylation relationship: occurs_in GO:1990421 ! subtelomeric heterochromatin created_by: midori creation_date: 2014-12-09T12:06:04Z [Term] id: FYPO:0004138 name: increased histone H3-K9 dimethylation at telomere def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the dimethylation of lysine at position 9 of histone H3 in telomeric regions occurs to a greater extent than normal." [PomBase:mah] synonym: "increased histone H3 K9 dimethylation at telomere" EXACT [GO:0036123, PomBase:mah] synonym: "increased histone H3-K9 dimethylation at telomere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H3-K9 dimethylation at telomere during vegetative growth" EXACT [PomBase:mah] synonym: "increased histone H3K9 dimethylation at telomere" EXACT [PomBase:vw] synonym: "increased histone H3K9me2 at telomere" EXACT [PomBase:mah] synonym: "increased histone lysine H3 K9 dimethylation at telomere" EXACT [GO:0036123, PomBase:mah] synonym: "increased telomeric histone H3-K9 dimethylation" EXACT [PomBase:mah] is_a: FYPO:0000873 ! increased histone H3-K9 dimethylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0036123 ! histone H3-K9 dimethylation intersection_of: occurs_at SO:0000624 ! telomere relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0036123 ! histone H3-K9 dimethylation relationship: occurs_at SO:0000624 ! telomere created_by: midori creation_date: 2014-12-09T12:08:36Z [Term] id: FYPO:0004139 name: altered level of substance in cell during nitrogen starvation def: "A cell phenotype in which the amount of a specific substance measured in a cell that is subject to nitrogen starvation differs from normal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "abnormal level of substance in cell during nitrogen starvation" EXACT [PomBase:mah] is_a: FYPO:0000989 ! altered level of substance in cell intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in CL:0000000 ! cell intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:24431 ! chemical entity relationship: exists_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in CL:0000000 ! cell relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:24431 ! chemical entity created_by: midori creation_date: 2014-12-09T12:14:06Z [Term] id: FYPO:0004140 name: increased cellular glutathione level during nitrogen starvation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of glutathione (GSH) measured in a cell that is subject to nitrogen starvation is higher than normal." [PomBase:mah] synonym: "increased cellular glutathione level during nitrogen depletion" EXACT [PomBase:mah] synonym: "increased cellular glutathione level during nitrogen deprivation" EXACT [PomBase:mah] synonym: "increased cellular GSH level during nitrogen starvation" EXACT [CHEBI:16856, PomBase:al] synonym: "increased cellular L-gamma-glutamyl-L-cysteinylglycine level during nitrogen starvation" EXACT [CHEBI:16856] synonym: "increased cellular reduced glutathione level during nitrogen starvation" EXACT [CHEBI:16856, PomBase:al] synonym: "increased glutathione accumulation during nitrogen starvation" RELATED [PomBase:mah] is_a: FYPO:0000990 ! increased level of substance in cell is_a: FYPO:0004139 ! altered level of substance in cell during nitrogen starvation intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:16856 ! glutathione relationship: exists_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:16856 ! glutathione created_by: midori creation_date: 2014-12-09T12:21:47Z [Term] id: FYPO:0004141 name: decreased cellular glutathione level during nitrogen starvation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of glutathione (GSH) measured in a cell that is subject to nitrogen starvation is lower than normal." [PomBase:mah] synonym: "decreased cellular glutathione level during nitrogen depletion" EXACT [PomBase:mah] synonym: "decreased cellular glutathione level during nitrogen deprivation" EXACT [PomBase:mah] synonym: "decreased cellular GSH level during nitrogen starvation" EXACT [CHEBI:16856, PomBase:al] synonym: "decreased cellular L-gamma-glutamyl-L-cysteinylglycine level during nitrogen starvation" EXACT [CHEBI:16856] synonym: "decreased cellular reduced glutathione level during nitrogen starvation" EXACT [CHEBI:16856, PomBase:al] synonym: "decreased glutathione accumulation during nitrogen starvation" RELATED [PomBase:mah] synonym: "reduced cellular glutathione level during nitrogen starvation" EXACT [PomBase:mah] is_a: FYPO:0000991 ! decreased level of substance in cell is_a: FYPO:0004139 ! altered level of substance in cell during nitrogen starvation intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:16856 ! glutathione relationship: exists_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:16856 ! glutathione created_by: midori creation_date: 2014-12-09T12:24:06Z [Term] id: FYPO:0004142 name: decreased RNA polymerase II core promoter proximal region sequence-specific DNA binding def: "A molecular function phenotype in which DNA binding at an RNA polymerase II core promoter proximal region by a gene product is decreased, when a gene or the bound DNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene. An RNA polymerase II core promoter proximal region is a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II." [GO:0000978, PomBase:mah] synonym: "decreased transcription factor binding to promoter region" RELATED [PomBase:al] synonym: "reduced RNA polymerase II core promoter proximal region sequence-specific DNA binding" EXACT [PomBase:mah] is_a: FYPO:0000658 ! decreased DNA binding intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0000978 ! RNA polymerase II core promoter proximal region sequence-specific DNA binding relationship: inheres_in GO:0000978 ! RNA polymerase II core promoter proximal region sequence-specific DNA binding created_by: midori creation_date: 2014-12-09T12:29:29Z [Term] id: FYPO:0004143 name: increased cellular nitrite level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of nitrite (NO2-) ions measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular nitrite accumulation" RELATED [PomBase:mah] synonym: "increased cellular nitrite ion level" EXACT [PomBase:al] synonym: "increased cellular nitrite level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular nitrite level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:16301 ! nitrite relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:16301 ! nitrite created_by: midori creation_date: 2014-12-09T12:46:07Z [Term] id: FYPO:0004144 name: decreased catalase activity during cellular response to nitrosative stress def: "A molecular function phenotype in which the observed rate of catalase activity is decreased during a cellular response to nitrosative stress." [PomBase:mah] synonym: "decreased catalase activity during nitrosative stress" EXACT [PomBase:al] synonym: "reduced catalase activity during cellular response to nitrosative stress" EXACT [PomBase:mah] is_a: FYPO:0003387 ! decreased catalase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: during GO:0071500 ! cellular response to nitrosative stress intersection_of: inheres_in GO:0004096 ! catalase activity relationship: during GO:0071500 ! cellular response to nitrosative stress relationship: inheres_in GO:0004096 ! catalase activity created_by: midori creation_date: 2014-12-09T12:48:20Z [Term] id: FYPO:0004145 name: abnormal pyridoxine:NADP 4-dehydrogenase activity def: "A molecular function phenotype in which the observed rate of pyridoxine:NADP 4-dehydrogenase activity is abnormal." [PomBase:mah] is_a: FYPO:0000689 ! abnormal oxidoreductase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0050236 ! pyridoxine:NADP 4-dehydrogenase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0050236 ! pyridoxine:NADP 4-dehydrogenase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-12-09T13:01:24Z [Term] id: FYPO:0004146 name: decreased pyridoxine:NADP 4-dehydrogenase activity def: "A molecular function phenotype in which the observed rate of pyridoxine:NADP 4-dehydrogenase activity is decreased." [PomBase:mah] synonym: "reduced pyridoxine:NADP 4-dehydrogenase activity" EXACT [PomBase:mah] is_a: FYPO:0000690 ! decreased oxidoreductase activity is_a: FYPO:0004145 ! abnormal pyridoxine:NADP 4-dehydrogenase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0050236 ! pyridoxine:NADP 4-dehydrogenase activity relationship: inheres_in GO:0050236 ! pyridoxine:NADP 4-dehydrogenase activity created_by: midori creation_date: 2014-12-09T13:01:30Z [Term] id: FYPO:0004147 name: increased pyridoxine:NADP 4-dehydrogenase activity def: "A molecular function phenotype in which the observed rate of pyridoxine:NADP 4-dehydrogenase activity is increased." [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0004145 ! abnormal pyridoxine:NADP 4-dehydrogenase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0050236 ! pyridoxine:NADP 4-dehydrogenase activity relationship: inheres_in GO:0050236 ! pyridoxine:NADP 4-dehydrogenase activity created_by: midori creation_date: 2014-12-09T13:01:35Z [Term] id: FYPO:0004148 name: normal pyridoxamine-phosphate oxidase activity def: "A molecular function phenotype in which the observed rate of pyridoxamine-phosphate oxidase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004733 ! pyridoxamine-phosphate oxidase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0004733 ! pyridoxamine-phosphate oxidase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-12-09T13:03:25Z [Term] id: FYPO:0004149 name: normal pyridoxal kinase activity def: "A molecular function phenotype in which the observed rate of pyridoxal kinase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0008478 ! pyridoxal kinase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0008478 ! pyridoxal kinase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-12-09T13:04:09Z [Term] id: FYPO:0004150 name: decreased cellular pyridoxamine 5'-phosphate level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of pyridoxamine 5'-phosphate measured in a cell is lower than normal." [PomBase:mah] synonym: "decreased cellular pyridoxamine 5'-phosphate level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular pyridoxamine 5'-phosphate level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased pyridoxamine 5'-phosphate accumulation" RELATED [PomBase:al] synonym: "reduced cellular pyridoxamine 5'-phosphate level" EXACT [PomBase:mah] is_a: FYPO:0001329 ! decreased level of substance in cell during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:18335 ! pyridoxamine 5'-phosphate relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:18335 ! pyridoxamine 5'-phosphate created_by: midori creation_date: 2014-12-09T13:16:47Z [Term] id: FYPO:0004151 name: decreased cellular pyridoxine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of pyridoxine measured in a cell is lower than normal." [PomBase:mah] synonym: "decreased cellular pyridoxine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular pyridoxine level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased pyridoxine accumulation" RELATED [PomBase:al] synonym: "reduced cellular pyridoxine level" EXACT [PomBase:mah] is_a: FYPO:0001329 ! decreased level of substance in cell during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:16709 ! pyridoxine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:16709 ! pyridoxine created_by: midori creation_date: 2014-12-09T13:19:20Z [Term] id: FYPO:0004152 name: increased cellular pyridoxal level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of pyridoxal measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular pyridoxal level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular pyridoxal level during vegetative growth" EXACT [PomBase:mah] synonym: "increased pyridoxal accumulation" RELATED [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:17310 ! pyridoxal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:17310 ! pyridoxal created_by: midori creation_date: 2014-12-09T13:20:26Z [Term] id: FYPO:0004153 name: increased flocculation in stationary phase def: "A cell population phenotype that reflects increased occurrence of flocculation when the population is in stationary phase. Flocculation is the non-sexual aggregation of single cells." [PMID:15047724, PomBase:mah] is_a: FYPO:0000155 ! increased flocculation created_by: midori creation_date: 2014-12-09T13:21:34Z [Term] id: FYPO:0004154 name: normal protein phosphorylation during cellular response to heat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins is normal (i.e. indistinguishable from wild type) during a cellular response to heat." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein phosphorylation during cellular response to heat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein phosphorylation during cellular response to heat during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000776 ! normal protein phosphorylation during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0034605 ! cellular response to heat intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0034605 ! cellular response to heat relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-12-09T13:37:08Z [Term] id: FYPO:0004155 name: increased protein tyrosine phosphorylation during mitotic G1 phase def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of tyrosine residues in one or more specific proteins, or of specific protein sites, occurs to a greater extent than normal during G1 phase of the mitotic cell cycle." [PomBase:mah] synonym: "increased peptidyl-tyrosine phosphorylation during mitotic G1 phase" EXACT [GO:0018108, PomBase:mah] synonym: "increased protein tyrosine phosphorylation during cellular response to heat during G1 phase during vegetative growth" EXACT [PomBase:mah] synonym: "increased protein tyrosine phosphorylation during cellular response to heat during G1 phase of mitotic cell cycle" EXACT [PomBase:mah] synonym: "increased tyrosine phosphorylation during mitotic G1 phase" EXACT [PomBase:al] is_a: FYPO:0001180 ! increased protein tyrosine phosphorylation is_a: FYPO:0004354 ! increased protein phosphorylation during mitotic G1 phase intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0000080 ! mitotic G1 phase intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0018108 ! peptidyl-tyrosine phosphorylation relationship: happens_during GO:0000080 ! mitotic G1 phase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0018108 ! peptidyl-tyrosine phosphorylation created_by: midori creation_date: 2014-12-09T13:38:08Z [Term] id: FYPO:0004156 name: decreased protein level during mitosis def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during mitosis is lower than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein accumulation during mitosis" RELATED [PomBase:mah] synonym: "decreased protein level during mitosis during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein level during mitotic M phase" EXACT [PomBase:mah] synonym: "decreased protein level during mitotic nuclear division" EXACT [GO:0007067] synonym: "reduced protein level during mitosis" EXACT [PomBase:mah] is_a: FYPO:0001324 ! decreased protein level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0007067 ! mitotic nuclear division intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0007067 ! mitotic nuclear division relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2014-12-09T13:42:41Z [Term] id: FYPO:0004157 name: increased protein level during mitosis def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during mitosis is higher than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein accumulation during mitosis" RELATED [PomBase:mah] synonym: "increased protein level during mitosis during vegetative growth" EXACT [PomBase:mah] synonym: "increased protein level during mitotic M phase" EXACT [PomBase:mah] synonym: "increased protein level during mitotic nuclear division" EXACT [GO:0007067] is_a: FYPO:0001327 ! increased protein level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0007067 ! mitotic nuclear division intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0007067 ! mitotic nuclear division relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2014-12-09T13:44:15Z [Term] id: FYPO:0004158 name: elongated vegetative cell with fragmented septum and more than four nuclei def: "A cell morphology phenotype in which vegetative a cell is longer than normal, and contains more than four nuclei and pieces of a septum that does not completely bisect the cell." [PMID:21931816, PomBase:mah] synonym: "elongated cell with fragmented septum and more than four nuclei during mitotic cell cycle" RELATED [PomBase:mah] synonym: "elongated cell with fragmented septum and more than four nuclei during vegetative growth" EXACT [PomBase:mah] synonym: "long vegetative cell with fragmented septum and more than four nuclei" EXACT [PomBase:mah] is_a: FYPO:0000133 ! elongated multinucleate vegetative cell created_by: midori creation_date: 2014-12-09T14:09:30Z [Term] id: FYPO:0004159 name: abnormal homologous chromosome segregation def: "A cellular process phenotype in which homologous chromosome segregation is abnormal. Homologous chromosome segregation is the process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle." [GO:0045143, PomBase:mah] synonym: "abnormal chromosome segregation during meiosis I" EXACT [PomBase:mah] is_a: FYPO:0000051 ! abnormal meiosis is_a: FYPO:0000151 ! abnormal meiotic chromosome segregation intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0045143 ! homologous chromosome segregation intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0045143 ! homologous chromosome segregation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-12-09T14:12:55Z [Term] id: FYPO:0004160 name: normal meiotic spindle def: "A physical cellular phenotype in which the meiotic spindle is normal (i.e. indistinguishable from wild type) with respect to structure, composition, location, and orientation." [PomBase:mah] synonym: "normal spindle during meiosis" EXACT [PomBase:mah] synonym: "normal spindle during meiotic nuclear division" EXACT [PomBase:mah] is_a: FYPO:0001231 ! normal cell cortex morphology is_a: FYPO:0004568 ! normal spindle intersection_of: PATO:0000001 ! quality intersection_of: exists_during GO:0007067 ! mitotic nuclear division intersection_of: inheres_in GO:0072687 ! meiotic spindle intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0007067 ! mitotic nuclear division relationship: inheres_in GO:0072687 ! meiotic spindle relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-12-09T14:23:08Z [Term] id: FYPO:0004161 name: decreased protein localization to chromatin at RNA polymerase II-regulated genes during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to regions of chromatin containing genes that can be transcribed by RNA polymerase II is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to chromatin at RNA polymerase II-regulated genes during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein localization to chromatin at polymerase II regulated genes" EXACT [PomBase:vw] synonym: "decreased protein localization to chromatin at RNA polymerase II-regulated genes during mitotic cell cycle" RELATED [PomBase:mah] synonym: "reduced protein localization to chromatin at RNA polymerase II-regulated genes during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002909 ! decreased protein localization to chromatin during vegetative growth created_by: midori creation_date: 2014-12-09T14:30:07Z [Term] id: FYPO:0004162 name: loss of viability upon glucose starvation def: "A cell population phenotype in which a smaller than normal proportion of the population remains viable when cells the population are subject to glucose starvation." [PomBase:mah] synonym: "decreased viability upon glucose starvation" EXACT [PomBase:mah] synonym: "loss of cell population viability upon glucose starvation" EXACT [PomBase:mah] synonym: "loss of viability upon glucose depletion" EXACT [PomBase:al] synonym: "loss of viability upon glucose deprivation" EXACT [PomBase:mah] synonym: "reduced viability upon glucose starvation" EXACT [PomBase:mah] is_a: FYPO:0000244 ! loss of viability upon nutrient depletion created_by: midori creation_date: 2014-12-09T14:38:44Z [Term] id: FYPO:0004163 name: increased viability upon glucose starvation def: "A cell population phenotype in which a larger than normal proportion of the population remains viable when cells the population are subject to glucose starvation." [PomBase:mah] synonym: "increased cell population viability upon glucose starvation" EXACT [PomBase:mah] synonym: "increased viability during glucose starvation" EXACT [PomBase:mah] synonym: "increased viability upon glucose depletion" EXACT [PomBase:al] synonym: "increased viability upon glucose deprivation" EXACT [PomBase:mah] is_a: FYPO:0002057 ! cell population viability created_by: midori creation_date: 2014-12-09T14:42:38Z [Term] id: FYPO:0004164 name: increased cellular reactive oxygen species level in stationary phase def: "A cell phenotype in which the amount of reactive oxygen species (ROS) measured in a cell is higher than normal when the population in which the cell is found is in stationary phase." [PomBase:mah] synonym: "increased cellular reactive oxygen species accumulation in stationary phase" RELATED [PomBase:mah] synonym: "increased cellular ROS accumulation in stationary phase" RELATED [PomBase:mah] synonym: "increased cellular ROS level in stationary phase" EXACT [PomBase:mah] synonym: "increased ROS accumulation in stationary phase" RELATED [PomBase:al] is_a: FYPO:0002142 ! altered cellular reactive oxygen species level created_by: midori creation_date: 2014-12-09T14:49:31Z [Term] id: FYPO:0004165 name: normal glucose consumption def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the amount of glucose consumed by cells in a given time is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal glucose uptake" RELATED [PomBase:vw] is_a: FYPO:0000257 ! normal phenotype is_a: FYPO:0001348 ! cellular metabolism phenotype during vegetative growth created_by: midori creation_date: 2014-12-09T14:50:40Z [Term] id: FYPO:0004166 name: increased oxygen consumption def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the amount of oxygen consumed by cells in a given time is higher than in wild type." [PomBase:mah] comment: Also see 'increased cellular respiration' (FYPO:0000565). synonym: "increased oxygen uptake" RELATED [PomBase:vw] is_a: FYPO:0001348 ! cellular metabolism phenotype during vegetative growth created_by: midori creation_date: 2014-12-09T14:54:31Z [Term] id: FYPO:0004167 name: increased cell population growth on glycerol carbon source def: "A vegetative cell population growth phenotype in which cell growth is increased relative to normal in a medium containing glycerol as the carbon source." [PomBase:al, PomBase:mah] comment: Note that trace amounts of another carbon source are usually required for S. pombe growth on glycerol; yeast extract-based rich medium supplies the trace substance, but minimal medium must be supplemented. It is therefore important to annotate the growth medium as an experimental condition when using this term. Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "increased growth on glycerol carbon source" BROAD [PomBase:mah] synonym: "increased vegetative cell growth on glycerol carbon source" EXACT [PomBase:mah] is_a: FYPO:0003937 ! increased cell population growth intersection_of: FYPO:0003937 ! increased cell population growth intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:17754 ! glycerol relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:17754 ! glycerol created_by: midori creation_date: 2014-12-09T15:00:22Z [Term] id: FYPO:0004168 name: normal viability in stationary phase during glucose limitation def: "A cell population phenotype in which a normal proportion of the population remains viable after entering stationary phase, under conditions of glucose limitation, such as in a medium that contains a low level of glucose and no other carbon source." [PomBase:mah] comment: Use this term if you have assayed growth of cells exposed to glucose limitation in culture. Note that glucose limitation differs from glucose starvation in that starvation results from complete absence of glucose, whereas limitation results from a shift from high to low glucose levels. Glucose concentrations below about 4.4 mM (0.08%) are typically regarded as limiting. synonym: "normal cell population viability in stationary phase during glucose limitation" EXACT [PomBase:mah] is_a: FYPO:0001310 ! normal viability in stationary phase created_by: midori creation_date: 2014-12-09T15:02:19Z [Term] id: FYPO:0004169 name: decreased RNA level in stationary phase def: "A cell phenotype in which the amount of RNA measured in a cell is lower than normal when the population in which the cell is found is in stationary phase. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased RNA accumulation in stationary phase" RELATED [PomBase:mah] synonym: "reduced RNA level in stationary phase" EXACT [PomBase:mah] is_a: FYPO:0000826 ! decreased RNA level created_by: midori creation_date: 2014-12-09T15:05:27Z [Term] id: FYPO:0004170 name: abolished histone H3-K9 dimethylation at centromere def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which dimethylation of lysine at position 9 of histone H3 in centromeric regions does not occur." [PomBase:mah] synonym: "abolished centromeric histone H3-K9 dimethylation" EXACT [PomBase:mah] synonym: "abolished histone H3 K9 dimethylation at centromere" EXACT [GO:0036123, PomBase:mah] synonym: "abolished histone H3-K9 dimethylation at centromere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished histone H3-K9 dimethylation at centromere during vegetative growth" EXACT [PomBase:mah] synonym: "abolished histone H3-K9 dimethylation at centromeric region" EXACT [PomBase:vw] synonym: "abolished histone H3K9me2 at centromere" EXACT [PomBase:mah] synonym: "abolished histone lysine H3 K9 dimethylation at centromere" EXACT [GO:0036123, PomBase:mah] synonym: "histone H3-K9 dimethylation abolished at centromere" EXACT [PomBase:mah] synonym: "histone H3-K9 dimethylation absent at centromere" EXACT [PomBase:al] is_a: FYPO:0002566 ! abolished histone H3-K9 methylation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: occurs_at SO:0001795 ! regional_centromere intersection_of: towards GO:0036123 ! histone H3-K9 dimethylation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: occurs_at SO:0001795 ! regional_centromere relationship: towards GO:0036123 ! histone H3-K9 dimethylation created_by: midori creation_date: 2014-12-09T15:23:37Z [Term] id: FYPO:0004171 name: normal RNA level during glucose starvation def: "A cell phenotype in which the amount of RNA measured in a cell that is subject to glucose starvation is normal (i.e. indistinguishable from wild type). Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "normal cellular RNA level during glucose starvation" EXACT [PomBase:mah] synonym: "normal mRNA level during glucose starvation" NARROW [PomBase:mah] synonym: "normal RNA accumulation during glucose starvation" RELATED [PomBase:mah] synonym: "normal RNA level during glucose depletion" EXACT [PomBase:vw] synonym: "normal RNA level during glucose deprivation" EXACT [PomBase:vw] is_a: FYPO:0000840 ! normal RNA level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0042149 ! cellular response to glucose starvation intersection_of: inheres_in CL:0000000 ! cell intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0042149 ! cellular response to glucose starvation relationship: inheres_in CL:0000000 ! cell relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-12-09T15:27:27Z [Term] id: FYPO:0004172 name: decreased protein kinase activity during cellular response to heat def: "A molecular function phenotype in which the observed rate of a protein kinase activity is decreased during a cellular response to heat." [PomBase:mah] synonym: "decreased protein kinase activity during cellular response to heat stress" EXACT [GO:0034605] synonym: "reduced protein kinase activity during cellular response to heat" EXACT [PomBase:mah] is_a: FYPO:0001382 ! decreased protein kinase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: during GO:0034605 ! cellular response to heat intersection_of: inheres_in GO:0004672 ! protein kinase activity relationship: during GO:0034605 ! cellular response to heat relationship: inheres_in GO:0004672 ! protein kinase activity created_by: midori creation_date: 2014-12-16T14:49:39Z [Term] id: FYPO:0004173 name: decreased protein phosphorylation during cellular response to heat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal during a cellular response to heat." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein phosphorylation during cellular response to heat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein phosphorylation during cellular response to heat during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein phosphorylation during cellular response to heat stress" EXACT [GO:0034605] synonym: "reduced protein phosphorylation during cellular response to heat" EXACT [PomBase:mah] is_a: FYPO:0001838 ! decreased protein phosphorylation during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0034605 ! cellular response to heat intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0034605 ! cellular response to heat relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2014-12-16T15:05:28Z [Term] id: FYPO:0004174 name: h+ specific sterility def: "A cellular process phenotype in which conjugation does not occur in cells of the h+ mating type." [PMID:9003326, PomBase:mah] synonym: "h+-specific sterility" EXACT [PomBase:mah] synonym: "h-plus-specific mating defect" RELATED [PMID:24727291] synonym: "h-plus-specific sterility" EXACT [PomBase:mah] is_a: FYPO:0000280 ! sterile created_by: midori creation_date: 2014-12-16T15:14:55Z [Term] id: FYPO:0004175 name: decreased mating efficiency in h- cells def: "A biological process phenotype in which the observed mating efficiency is lower than normal in cells of the h- mating type." [PMID:8668157, PomBase:al, PomBase:mah] comment: Note that mating efficiency is often measured by counting zygotes plus asci, sometimes also including spores, so a change in measured mating efficiency may reflect a change in conjugation frequency (see FYPO:0000031 and its descendants), a change in sporulation (see FYPO:0000121 and its descendants), or both. For this reason, this term is not a child of 'mating phenotype' (FYPO:0000031). synonym: "reduced mating efficiency in h- cells" EXACT [PomBase:mah] is_a: FYPO:0000708 ! decreased mating efficiency created_by: midori creation_date: 2014-12-16T15:16:01Z [Term] id: FYPO:0004176 name: decreased RNA level during cellular response to pheromone and nitrogen starvation def: "A cell phenotype in which the amount of RNA measured in a cell during a cellular response to a pheromone that occurs when the cell is subject to nitrogen starvation is lower than normal. Total RNA or a specific RNA may be affected." [PMID:8668157, PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased RNA accumulation during cellular response to pheromone and nitrogen starvation" RELATED [PomBase:mah] synonym: "decreased transcript level during cellular response to pheromone and nitrogen starvation" EXACT [PomBase:vw] synonym: "reduced RNA level during cellular response to pheromone and nitrogen starvation" EXACT [PomBase:mah] is_a: FYPO:0001152 ! decreased RNA level during nitrogen starvation is_a: FYPO:0003426 ! decreased RNA level during cellular response to pheromone intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: exists_during GO:0071444 ! cellular response to pheromone intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0006995 ! cellular response to nitrogen starvation relationship: exists_during GO:0071444 ! cellular response to pheromone relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-12-16T15:26:56Z [Term] id: FYPO:0004177 name: increased RNA level during nitrogen starvation in h- cells def: "A cell phenotype in which the amount of RNA measured in a cell of the h- mating type when the cell is subject to nitrogen starvation is higher than normal. Total RNA or a specific RNA may be affected." [PMID:8668157, PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased RNA accumulation during nitrogen starvation in h- cells" RELATED [PomBase:mah] synonym: "increased RNA level during nitrogen depletion in h- cells" EXACT [PomBase:vw] synonym: "increased RNA level during nitrogen deprivation in h- cells" EXACT [PomBase:vw] synonym: "increased transcript level during nitrogen starvation in h- cells" EXACT [PomBase:vw] is_a: FYPO:0002020 ! increased RNA level during nitrogen starvation intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in CL:0002674 ! H minus intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in CL:0002674 ! H minus relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-12-16T15:28:56Z [Term] id: FYPO:0004178 name: increased RNA level during nitrogen starvation in h+ cells def: "A cell phenotype in which the amount of RNA measured in a cell of the h+ mating type when the cell is subject to nitrogen starvation is higher than normal. Total RNA or a specific RNA may be affected." [PMID:8668157, PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased RNA accumulation during nitrogen starvation in h+ cells" RELATED [PomBase:mah] synonym: "increased RNA level during nitrogen depletion in h+ cells" EXACT [PomBase:vw] synonym: "increased RNA level during nitrogen deprivation in h+ cells" EXACT [PomBase:vw] synonym: "increased transcript level during nitrogen starvation in h+ cells" EXACT [PomBase:vw] is_a: FYPO:0002020 ! increased RNA level during nitrogen starvation intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in CL:0002675 ! H plus intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in CL:0002675 ! H plus relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-12-16T15:34:31Z [Term] id: FYPO:0004179 name: decreased protein aggregate fusion def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which small aggregates of misfolded protein fuse into larger aggregates to a lower extent than normal." [PMID:24936793, PomBase:mah] synonym: "reduced protein aggregate fusion" EXACT [PomBase:mah] is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth created_by: midori creation_date: 2014-12-16T15:49:33Z [Term] id: FYPO:0004180 name: increased cellular protein aggregate level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein present as aggregates of misfolded protein is greater than normal." [PMID:24936793, PomBase:mah] is_a: FYPO:0001327 ! increased protein level during vegetative growth created_by: midori creation_date: 2014-12-16T15:52:38Z [Term] id: FYPO:0004181 name: normal protein localization to cell-cell contact point during conjugation def: "A cell phenotype in which the localization of a protein to the region of contact between two cells undergoing conjugation is normal (i.e. indistinguishable from wild type)." [PMID:24514900, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to cell-cell contact point during conjugation" EXACT [PomBase:mah] is_a: FYPO:0003627 ! normal protein localization created_by: midori creation_date: 2014-12-16T15:57:02Z [Term] id: FYPO:0004182 name: normal vegetative growth on papuamide B def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing papuamide B." [PomBase:mah] synonym: "normal cellular response to papuamide B during vegetative growth" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth in presence of papuamide B" EXACT [PomBase:mah] synonym: "normal vegetative cell population growth on papuamide B" EXACT [PomBase:al, PomBase:mah, PomBase:vw] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:83265 ! papuamide B relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:83265 ! papuamide B created_by: midori creation_date: 2014-12-16T16:00:05Z [Term] id: FYPO:0004183 name: normal growth on papuamide B during mating def: "A phenotype in which cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing papuamide B when cells in the population are undergoing conjugation." [PomBase:mah] synonym: "normal cell population growth in presence of papuamide B during mating" EXACT [PomBase:mah] synonym: "normal cell population growth on papuamide B during mating" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to papuamide B during mating" RELATED [PomBase:al, PomBase:mah] synonym: "normal growth on papuamide B during conjugation with cellular fusion" EXACT [GO:0000747] is_a: FYPO:0000047 ! normal cell population growth intersection_of: FYPO:0000047 ! normal cell population growth intersection_of: happens_during GO:0000747 ! conjugation with cellular fusion intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:83265 ! papuamide B relationship: happens_during GO:0000747 ! conjugation with cellular fusion relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:83265 ! papuamide B created_by: midori creation_date: 2014-12-16T16:02:45Z [Term] id: FYPO:0004184 name: sensitive to papuamide B during vegetative growth def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to papuamide B. Cells stop growing (and may die) at a concentration of papuamide B that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to papuamide B during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to papuamide B during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:83265 ! papuamide B relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:83265 ! papuamide B created_by: midori creation_date: 2014-12-16T16:08:57Z [Term] id: FYPO:0004185 name: sensitive to myriocin during mating def: "A phenotype in which cells show increased sensitivity to myriocin during mating. Cells stop growing (and may die) at a concentration of myriocin that allows wild type cells to grow." [PMID:24514900, PomBase:mah] synonym: "sensitive to myriocin during conjugation with cellular fusion" EXACT [GO:0000747] synonym: "sensitivity to chemicals interfering with lipids during mating" BROAD [PMID:24514900] is_a: FYPO:0002683 ! increased sensitivity to chemical intersection_of: FYPO:0002683 ! increased sensitivity to chemical intersection_of: during GO:0000747 ! conjugation with cellular fusion intersection_of: towards CHEBI:582124 ! myriocin relationship: during GO:0000747 ! conjugation with cellular fusion relationship: towards CHEBI:582124 ! myriocin created_by: midori creation_date: 2014-12-16T16:10:07Z [Term] id: FYPO:0004186 name: normal vegetative growth on myriocin def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing myriocin." [PomBase:mah] synonym: "normal cellular response to myriocin during vegetative growth" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth in presence of myriocin" EXACT [PomBase:mah] synonym: "normal vegetative cell population growth on myriocin" EXACT [PomBase:al, PomBase:mah, PomBase:vw] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:582124 ! myriocin relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:582124 ! myriocin created_by: midori creation_date: 2014-12-16T16:16:39Z [Term] id: FYPO:0004187 name: abolished protein export from nucleus during cellular response to hydroxyurea def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which protein export from the nucleus does not occur during a cellular response to hydroxyurea. Export of all proteins or a specific protein may be affected." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein export from nucleus during cellular response to hydroxyurea during mitotic cell cycle" RELATED [PomBase:mah] synonym: "absent protein export from nucleus during cellular response to hydroxyurea" EXACT [PomBase:mah] synonym: "protein export from nucleus abolished during cellular response to hydroxyurea" EXACT [PomBase:mah] synonym: "protein export from nucleus abolished during cellular response to hydroxyurea during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001921 ! abolished protein export from nucleus intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: during GO:0072711 ! cellular response to hydroxyurea intersection_of: towards GO:0006611 ! protein export from nucleus relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: during GO:0072711 ! cellular response to hydroxyurea relationship: towards GO:0006611 ! protein export from nucleus created_by: midori creation_date: 2014-12-16T16:19:00Z [Term] id: FYPO:0004188 name: abolished protein localization to nucleus during cellular response to hydroxyurea def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleus is abolished during a cellular response to hydroxyurea." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to nucleus during cellular response to hydroxyurea" EXACT [PomBase:mah] synonym: "abolished protein localization to nucleus during cellular response to HU" EXACT [PomBase:al] synonym: "abolished protein localization to nucleus during cellular response to hydroxyurea during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to nucleus during cellular response to hydroxyurea during vegetative growth" EXACT [PomBase:mah] synonym: "protein localization to nucleus abolished during cellular response to hydroxyurea" EXACT [PomBase:mah] is_a: FYPO:0001424 ! abolished protein localization to nucleus during vegetative growth intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: during GO:0072711 ! cellular response to hydroxyurea intersection_of: towards GO:0034504 ! protein localization to nucleus relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: during GO:0072711 ! cellular response to hydroxyurea relationship: towards GO:0034504 ! protein localization to nucleus created_by: midori creation_date: 2014-12-16T16:21:30Z [Term] id: FYPO:0004189 name: increased protein level during cellular response to hydroxyurea def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during a cellular response to hydroxyurea is higher than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein accumulation during cellular response to hydroxyurea" RELATED [PomBase:mah] synonym: "increased protein level during cellular response to HU" EXACT [PomBase:mah] synonym: "increased protein level during cellular response to hydroxyurea during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein level during cellular response to hydroxyurea during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001327 ! increased protein level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: exists_during GO:0072711 ! cellular response to hydroxyurea intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: exists_during GO:0072711 ! cellular response to hydroxyurea relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2014-12-16T16:23:00Z [Term] id: FYPO:0004190 name: decreased protein level during cellular response to ionizing radiation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during a cellular response to ionizing radiation is lower than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein accumulation during cellular response to ionizing radiation" RELATED [PomBase:mah] synonym: "decreased protein level during cellular response to ionizing radiation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein level during cellular response to ionizing radiation during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein level during cellular response to ionizing radiation" EXACT [PomBase:mah] is_a: FYPO:0001324 ! decreased protein level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0071480 ! cellular response to gamma radiation intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0071480 ! cellular response to gamma radiation relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2014-12-16T16:25:07Z [Term] id: FYPO:0004191 name: increased RNA level during cellular response to hydroxyurea def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to hydroxyurea is higher than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased mRNA level during cellular response to hydroxyurea" NARROW [PomBase:mah] synonym: "increased RNA accumulation during cellular response to hydroxyurea" RELATED [PomBase:mah] synonym: "increased RNA level during cellular response to HU" EXACT [PomBase:mah] synonym: "increased RNA level during cellular response to hydroxyurea during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased RNA level during cellular response to hydroxyurea during vegetative growth" EXACT [PomBase:mah] synonym: "increased transcript level during cellular response to hydroxyurea" EXACT [PomBase:vw] is_a: FYPO:0000825 ! increased RNA level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: exists_during GO:0072711 ! cellular response to hydroxyurea intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: exists_during GO:0072711 ! cellular response to hydroxyurea relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-12-16T16:26:11Z [Term] id: FYPO:0004192 name: decreased RNA level during cellular response to ionizing radiation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to ionizing radiation is lower than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased RNA accumulation during cellular response to ionizing radiation" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to ionizing radiation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to ionizing radiation during vegetative growth" EXACT [PomBase:mah] synonym: "decreased transcript level during cellular response to ionizing radiation" EXACT [PomBase:vw] synonym: "reduced RNA level during cellular response to ionizing radiation" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0071480 ! cellular response to gamma radiation intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0071480 ! cellular response to gamma radiation relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2014-12-17T11:46:42Z [Term] id: FYPO:0004193 name: decreased protein level during mitotic S phase def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during S phase of the mitotic cell cycle is lower than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein accumulation during mitotic S phase" RELATED [PomBase:mah] synonym: "decreased protein level during mitotic S phase during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein level during S phase of mitotic cell cycle" EXACT [PomBase:mah] synonym: "reduced protein level during mitotic S phase" EXACT [PomBase:mah] is_a: FYPO:0001324 ! decreased protein level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0000084 ! mitotic S phase intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0000084 ! mitotic S phase relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2014-12-17T12:02:18Z [Term] id: FYPO:0004194 name: decreased protein level during cellular response to hydroxyurea def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during a cellular response to hydroxyurea is lower than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein accumulation during cellular response to hydroxyurea" RELATED [PomBase:mah] synonym: "decreased protein level during cellular response to HU" EXACT [PomBase:mah] synonym: "decreased protein level during cellular response to hydroxyurea during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein level during cellular response to hydroxyurea during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein level during cellular response to hydroxyurea" EXACT [PomBase:mah] is_a: FYPO:0001324 ! decreased protein level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: exists_during GO:0072711 ! cellular response to hydroxyurea intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: exists_during GO:0072711 ! cellular response to hydroxyurea relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2014-12-17T12:03:24Z [Term] id: FYPO:0004195 name: normal protein localization to telomere during meiosis def: "A cell phenotype in which the localization of a protein to the telomere of a chromosome is normal (i.e. indistinguishable from wild type) during one or both meiotic nuclear divisions." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to chromosome, telomeric region, during meiosis" EXACT [GO:0070198, PomBase:mah] synonym: "normal protein localisation to telomere during meiosis" EXACT [PomBase:mah] synonym: "normal protein localization to chromosome, telomeric region, during meiosis" EXACT [GO:0070198, PomBase:mah] synonym: "normal protein localization to telomere during meiotic nuclear division" EXACT [PomBase:mah] is_a: FYPO:0003790 ! normal protein localization during meiosis intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0007126 ! meiotic nuclear division intersection_of: inheres_in GO:0070198 ! protein localization to chromosome, telomeric region intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0007126 ! meiotic nuclear division relationship: inheres_in GO:0070198 ! protein localization to chromosome, telomeric region relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-12-17T12:34:00Z [Term] id: FYPO:0004196 name: inviable after spore germination, single or double cell division, elongated multiseptate cell with fragmented nucleus def: "A phenotype in which a spore germinates to produce a cell that is longer than normal, has more than one septum and a nucleus that is broken into multiple small fragments, and undergoes one or two rounds of cell division." [PomBase:mah] synonym: "essential; germinating spore, single or double cell division, elongated multiseptate cell with fragmented nucleus" RELATED [PomBase:mah] synonym: "inviable following spore germination, single or double cell division, elongated multiseptate cell with fragmented nucleus" EXACT [PomBase:mah] synonym: "inviable germinated spore, single or double cell division, elongated multiseptate cell with fragmented nucleus" EXACT [PomBase:mah] is_a: FYPO:0004076 ! inviable after spore germination, single or double cell division, elongated multiseptate cell created_by: midori creation_date: 2014-12-17T13:22:48Z [Term] id: FYPO:0004197 name: inviable elongated vegetative cell with fragmented nucleus and mitotic cell cycle arrest in interphase def: "A cell morphology phenotype in which a vegetative cell is inviable and longer than normal, has a nucleus that is broken into multiple small fragments, and progress through the mitotic cell cycle is arrested in interphase. The cell contains no septum." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "elongated inviable cell with fragmented nucleus and mitotic cell cycle arrest in interphase during vegetative growth" EXACT [PomBase:mah] synonym: "elongated inviable vegetative cell with fragmented nucleus and mitotic cell cycle arrest in interphase" EXACT [PomBase:mah] synonym: "essential; elongated vegetative cell with fragmented nucleus and mitotic cell cycle arrest in interphase" RELATED [PomBase:mah] synonym: "inviable elongated mononucleate aseptate vegetative cell with fragmented nucleus and cell cycle arrest in mitotic interphase" EXACT [PomBase:vw] synonym: "mitotic cell cycle arrest in interphase and elongated inviable cell with fragmented nucleus" EXACT [PomBase:vw] synonym: "mitotic interphase arrested elongated inviable vegetative cell" EXACT [PomBase:mah] is_a: FYPO:0001497 ! inviable elongated vegetative cell with mitotic cell cycle arrest in interphase intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000837 ! cell cycle arrest in mitotic interphase intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0001919 ! fragmented nucleus relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000837 ! cell cycle arrest in mitotic interphase relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0001919 ! fragmented nucleus created_by: midori creation_date: 2014-12-17T13:28:37Z [Term] id: FYPO:0004198 name: decreased protein degradation during mitosis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of protein degradation is decreased during mitosis." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein breakdown during mitosis" EXACT [GO:0030163, PomBase:mah] synonym: "decreased protein catabolic process during mitosis" EXACT [GO:0030163, PomBase:mah] synonym: "decreased protein catabolism during mitosis" EXACT [GO:0030163, PomBase:mah] synonym: "decreased protein degradation during mitotic M phase" RELATED [PomBase:mah] synonym: "decreased protein degradation during mitotic nuclear division" EXACT [GO:0007067] synonym: "reduced protein degradation during mitosis" EXACT [PomBase:mah] is_a: FYPO:0000846 ! decreased protein degradation during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0007067 ! mitotic nuclear division intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0030163 ! protein catabolic process relationship: happens_during GO:0007067 ! mitotic nuclear division relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0030163 ! protein catabolic process created_by: midori creation_date: 2014-12-17T13:44:14Z [Term] id: FYPO:0004199 name: increased protein degradation during mitosis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of protein degradation is increased during mitosis." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein breakdown during mitosis" EXACT [GO:0030163, PomBase:mah] synonym: "increased protein catabolic process during mitosis" EXACT [GO:0030163, PomBase:mah] synonym: "increased protein catabolism during mitosis" EXACT [GO:0030163, PomBase:mah] synonym: "increased protein degradation during mitotic M phase" RELATED [PomBase:mah] synonym: "increased protein degradation during mitotic nuclear division" EXACT [GO:0007067] is_a: FYPO:0000847 ! increased protein degradation during vegetative growth intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0007067 ! mitotic nuclear division intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0030163 ! protein catabolic process relationship: happens_during GO:0007067 ! mitotic nuclear division relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0030163 ! protein catabolic process created_by: midori creation_date: 2014-12-17T13:46:11Z [Term] id: FYPO:0004200 name: increased protein degradation during mitotic G1 phase def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of protein degradation is increased during G1 phase of the mitotic cell cycle." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein breakdown during mitotic G1 phase" EXACT [GO:0030163, PomBase:mah] synonym: "increased protein catabolic process during mitotic G1 phase" EXACT [GO:0030163, PomBase:mah] synonym: "increased protein catabolism during mitotic G1 phase during vegetative growth" EXACT [GO:0030163, PomBase:mah] synonym: "increased protein degradation during G1 phase of mitotic cell cycle" EXACT [PomBase:mah] is_a: FYPO:0000847 ! increased protein degradation during vegetative growth intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0000080 ! mitotic G1 phase intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0030163 ! protein catabolic process relationship: happens_during GO:0000080 ! mitotic G1 phase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0030163 ! protein catabolic process created_by: midori creation_date: 2014-12-17T13:47:17Z [Term] id: FYPO:0004201 name: decreased centromeric outer repeat transcript-derived siRNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which small interfering RNA transcripts derived from the centromere outer repeat region are present at lower levels than normal." [PMID:20211136, PomBase:mah] comment: This term refers specifically to siRNAs derived by dicer-mediated processing of RNA from the centromere outer repeat region. Use this term only for levels of RNA transcribed from endogenous centromere outer repeat sequences. synonym: "decreased accumulation of centromeric outer repeat transcript-derived siRNA" EXACT [PomBase:mah] synonym: "decreased accumulation of siRNAs homologous to outer repeats" RELATED [PomBase:vw] synonym: "decreased centromere outer repeat transcript-derived siRNA level" EXACT [PomBase:mah] synonym: "decreased centromeric outer repeat transcript-derived siRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased centromeric outer repeat transcript-derived siRNA level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased level of centromeric outer repeat transcript-derived siRNA" EXACT [PomBase:mah] synonym: "decreased level of siRNAs homologous to outer repeats" EXACT [PomBase:vw] synonym: "reduced centromeric outer repeat transcript-derived siRNA level" EXACT [PomBase:mah] is_a: FYPO:0003094 ! decreased centromeric outer repeat transcript level is_a: FYPO:0004205 ! decreased siRNA level created_by: midori creation_date: 2014-12-17T14:54:21Z [Term] id: FYPO:0004202 name: decreased spliced cen-dg RNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which spliced forms of RNAs transcribed from dg repeats in the centromere outer repeat region are present at lower levels than normal." [PMID:25274039, PomBase:mah] synonym: "decreased level of spliced cen-dg RNA" EXACT [PomBase:mah] synonym: "decreased level of spliced cen-dg transcripts" EXACT [PomBase:mah] synonym: "decreased level of spliced centromeric dg repeat RNA" EXACT [PomBase:mah] synonym: "decreased level of spliced centromeric dg repeat transcripts" EXACT [PomBase:mah] synonym: "decreased spliced cen-dg RNA accumulation" RELATED [PomBase:mah] synonym: "decreased spliced cen-dg RNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased spliced cen-dg RNA level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased spliced cen-dg transcript level" EXACT [PomBase:mah] synonym: "reduced spliced cen-dg RNA level" EXACT [PomBase:mah] is_a: FYPO:0003094 ! decreased centromeric outer repeat transcript level created_by: midori creation_date: 2014-12-17T14:57:59Z [Term] id: FYPO:0004203 name: increased calcium import def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of calcium ions into a cell occurs to a greater extent than normal." [PomBase:mah] synonym: "increased calcium import during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased calcium import during vegetative growth" EXACT [PomBase:mah] synonym: "increased calcium import into cell" EXACT [PomBase:mah] synonym: "increased calcium ion import" EXACT [PomBase:mah] synonym: "increased calcium uptake" EXACT [PomBase:mah] synonym: "increased calcium uptake into intracellular compartments" RELATED [PomBase:vw] synonym: "increased cellular calcium import" EXACT [PomBase:al] is_a: FYPO:0001953 ! abnormal calcium import is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990035 ! calcium ion import into cell relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990035 ! calcium ion import into cell created_by: midori creation_date: 2014-12-17T15:05:32Z [Term] id: FYPO:0004204 name: decreased snRNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of mature snRNA measured in a cell is lower than normal." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased mature snRNA level" EXACT [PomBase:mah] synonym: "decreased small nuclear RNA level" EXACT [PomBase:mah] synonym: "decreased snRNA accumulation" RELATED [PomBase:mah] synonym: "decreased snRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased snRNA level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased snRNA transcript level" BROAD [PomBase:vw] synonym: "reduced snRNA level" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards SO:0000274 ! snRNA relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards SO:0000274 ! snRNA created_by: midori creation_date: 2014-12-19T10:48:11Z [Term] id: FYPO:0004205 name: decreased siRNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of mature siRNA measured in a cell is lower than normal." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased mature siRNA level" EXACT [PomBase:mah] synonym: "decreased siRNA accumulation" RELATED [PomBase:mah] synonym: "decreased siRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased siRNA level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased small interfering RNA level" EXACT [PomBase:mah] synonym: "reduced siRNA level" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards SO:0000646 ! siRNA relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards SO:0000646 ! siRNA created_by: midori creation_date: 2014-12-19T10:49:16Z [Term] id: FYPO:0004206 name: increased snRNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of mature snRNA measured in a cell is higher than normal." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased mature snRNA level" EXACT [PomBase:mah] synonym: "increased small nuclear RNA level" EXACT [PomBase:mah] synonym: "increased snRNA accumulation" RELATED [PomBase:mah] synonym: "increased snRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased snRNA level during vegetative growth" EXACT [PomBase:mah] synonym: "increased snRNA transcript level" BROAD [PomBase:vw] is_a: FYPO:0000825 ! increased RNA level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards SO:0000274 ! snRNA relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards SO:0000274 ! snRNA created_by: midori creation_date: 2014-12-19T10:50:02Z [Term] id: FYPO:0004207 name: increased siRNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of mature siRNA measured in a cell is higher than normal." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased mature siRNA level" EXACT [PomBase:mah] synonym: "increased siRNA accumulation" RELATED [PomBase:mah] synonym: "increased siRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased siRNA level during vegetative growth" EXACT [PomBase:mah] synonym: "increased small interfering RNA level" EXACT [PomBase:mah] is_a: FYPO:0000825 ! increased RNA level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards SO:0000646 ! siRNA relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards SO:0000646 ! siRNA created_by: midori creation_date: 2014-12-19T10:50:41Z [Term] id: FYPO:0004208 name: abnormal histone methyltransferase activity (H3-K4 specific) def: "A molecular function phenotype in which the observed rate of H3-K4 specific histone methyltransferase activity is abnormal." [PomBase:mah] is_a: FYPO:0004783 ! abnormal histone methyltransferase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0042800 ! histone methyltransferase activity (H3-K4 specific) intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0042800 ! histone methyltransferase activity (H3-K4 specific) relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-12-19T11:30:25Z [Term] id: FYPO:0004209 name: abolished histone methyltransferase activity (H3-K4 specific) def: "A molecular function phenotype in which H3-K4 specific histone methyltransferase activity is absent." [PomBase:mah] synonym: "histone methyltransferase activity (H3-K4 specific) abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0004208 ! abnormal histone methyltransferase activity (H3-K4 specific) intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0042800 ! histone methyltransferase activity (H3-K4 specific) relationship: towards GO:0042800 ! histone methyltransferase activity (H3-K4 specific) created_by: midori creation_date: 2014-12-19T11:30:30Z [Term] id: FYPO:0004210 name: incomplete mitotic sister chromatid segregation, with unseparated DNA and centromeric DNA dissociated from spindle def: "A cellular process phenotype in which mitotic sister chromatid segregation stops before completing separation of chromosomes, DNA remains in a single mass at or near the midpoint of the mitotic spindle, and centromeric DNA is not closely associated with the mitotic spindle." [PMID:16855021, PomBase:mah] synonym: "incomplete mitotic sister chromatid segregation, with unseparated DNA and centromeric DNA dissociated from spindle during vegetative growth" EXACT [PomBase:mah] synonym: "incomplete mitotic sister chromatid separation, with unseparated DNA and centromeric DNA dissociated from spindle" RELATED [PomBase:mah] is_a: FYPO:0003758 ! incomplete mitotic sister chromatid segregation, with unseparated DNA created_by: midori creation_date: 2014-12-19T12:42:19Z [Term] id: FYPO:0004211 name: incomplete mitotic sister chromatid segregation, with unseparated DNA and centromeric DNA associated with spindle def: "A cellular process phenotype in which mitotic sister chromatid segregation stops before completing separation of chromosomes, DNA remains in a single mass at or near the midpoint of the mitotic spindle, and centromeric DNA is closely associated with the mitotic spindle." [PomBase:mah, PomBase:vw] synonym: "incomplete mitotic sister chromatid segregation, with unseparated DNA and centromeric DNA associated with spindle during vegetative growth" EXACT [PomBase:mah] synonym: "incomplete mitotic sister chromatid separation, with unseparated DNA and centromeric DNA associated with spindle" RELATED [PomBase:mah] is_a: FYPO:0003758 ! incomplete mitotic sister chromatid segregation, with unseparated DNA created_by: midori creation_date: 2014-12-19T12:51:21Z [Term] id: FYPO:0004212 name: decreased protein localization to kinetochore during meiosis I def: "A cell phenotype in which the localization of a protein to the kinetochore of a chromosome is decreased during the first meiotic nuclear division." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to kinetochore during meiosis I" EXACT [PomBase:mah] synonym: "decreased protein localization to kinetochore during first meiotic nuclear division" EXACT [PomBase:mah] synonym: "decreased protein localization to meiotic kinetochore during meiosis I" EXACT [PomBase:vw] synonym: "reduced protein localization to kinetochore during meiosis I" EXACT [PomBase:mah] is_a: FYPO:0004762 ! abnormal protein localization to kinetochore during meiosis is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0007127 ! meiosis I intersection_of: inheres_in GO:0034501 ! protein localization to kinetochore relationship: happens_during GO:0007127 ! meiosis I relationship: inheres_in GO:0034501 ! protein localization to kinetochore created_by: midori creation_date: 2014-12-19T13:00:18Z [Term] id: FYPO:0004213 name: abnormal attachment of mitotic spindle microtubules to kinetochore def: "A cellular process phenotype in which the physical attachment of sister chromatids to mitotic spindle microtubules is abnormal." [PomBase:mah] comment: This term is less specific than 'abnormal sister chromatid biorientation' (FYPO:0000326) because sister chromatid biorientation normally occurs only as part of metaphase plate congression, not during other stages of mitosis. FYPO:0004213 can be used for abnormal attachment observed at any time during mitosis. synonym: "abnormal attachment of mitotic spindle microtubules to kinetochore during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal attachment of spindle microtubules to kinetochore during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal attachment of spindle microtubules to kinetochore mitosis" EXACT [PomBase:mah] is_a: FYPO:0000325 ! abnormal attachment of spindle microtubules to kinetochore is_a: FYPO:0002737 ! abnormal mitotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0051315 ! attachment of mitotic spindle microtubules to kinetochore intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0051315 ! attachment of mitotic spindle microtubules to kinetochore relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-12-19T13:09:48Z [Term] id: FYPO:0004214 name: normal protein localization to kinetochore during meiosis I def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the kinetochore of a chromosome is normal (i.e. indistinguishable from wild type) during the first meiotic nuclear division." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to kinetochore during meiosis I" EXACT [PomBase:mah] synonym: "normal protein localization to kinetochore during first meiotic nuclear division" EXACT [PomBase:mah] is_a: FYPO:0003790 ! normal protein localization during meiosis intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0007127 ! meiosis I intersection_of: inheres_in GO:0034501 ! protein localization to kinetochore intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0007127 ! meiosis I relationship: inheres_in GO:0034501 ! protein localization to kinetochore relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-12-19T13:43:10Z [Term] id: FYPO:0004215 name: abnormal histone H4-K20 methylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which methylation of lysine at position 20 of histone H4 is abnormal." [PomBase:mah] synonym: "abnormal histone H4 K20 methylation" EXACT [GO:0034770, PomBase:mah] synonym: "abnormal histone H4-K20 methylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal histone H4-K20 methylation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal histone H4K20me" EXACT [GO:0034770, PomBase:mah] synonym: "abnormal histone lysine H4 K20 methylation" EXACT [GO:0034770, PomBase:mah] is_a: FYPO:0000457 ! abnormal histone methylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0034770 ! histone H4-K20 methylation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0034770 ! histone H4-K20 methylation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-12-19T14:50:23Z [Term] id: FYPO:0004216 name: abolished histone H4-K20 monomethylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which monomethylation of lysine at position 20 of histone H4 does not occur." [PomBase:mah] synonym: "abolished histone H4 K20 monomethylation" EXACT [GO:0034771, PomBase:mah] synonym: "abolished histone H4-K20 monomethylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished histone H4-K20 monomethylation during vegetative growth" EXACT [PomBase:mah] synonym: "abolished histone H4K20me1" EXACT [PomBase:mah] synonym: "abolished histone lysine H4 K20 monomethylation" EXACT [GO:0034771, PomBase:mah] synonym: "histone H4-K20 monomethylation abolished" EXACT [PomBase:mah] synonym: "histone H4-K20 monomethylation absent" EXACT [PomBase:al] is_a: FYPO:0002565 ! abolished histone methylation is_a: FYPO:0004215 ! abnormal histone H4-K20 methylation is_a: FYPO:0004488 ! abolished protein lysine methylation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0034771 ! histone H4-K20 monomethylation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0034771 ! histone H4-K20 monomethylation created_by: midori creation_date: 2014-12-19T14:52:43Z [Term] id: FYPO:0004217 name: abolished histone H4-K20 dimethylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which dimethylation of lysine at position 20 of histone H4 does not occur." [PomBase:mah] synonym: "abolished histone H4 K20 dimethylation" EXACT [GO:0034772, PomBase:mah] synonym: "abolished histone H4-K20 dimethylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished histone H4-K20 dimethylation during vegetative growth" EXACT [PomBase:mah] synonym: "abolished histone H4K20me2" EXACT [PomBase:mah] synonym: "abolished histone lysine H4 K20 dimethylation" EXACT [GO:0034772, PomBase:mah] synonym: "histone H4-K20 dimethylation abolished" EXACT [PomBase:mah] synonym: "histone H4-K20 dimethylation absent" EXACT [PomBase:al] is_a: FYPO:0002565 ! abolished histone methylation is_a: FYPO:0004215 ! abnormal histone H4-K20 methylation is_a: FYPO:0004488 ! abolished protein lysine methylation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0034772 ! histone H4-K20 dimethylation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0034772 ! histone H4-K20 dimethylation created_by: midori creation_date: 2014-12-19T15:00:01Z [Term] id: FYPO:0004218 name: abolished histone H4-K20 trimethylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which trimethylation of lysine at position 20 of histone H4 does not occur." [PomBase:mah] synonym: "abolished histone H4 K20 trimethylation" EXACT [GO:0034773, PomBase:mah] synonym: "abolished histone H4-K20 trimethylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished histone H4-K20 trimethylation during vegetative growth" EXACT [PomBase:mah] synonym: "abolished histone H4K20me3" EXACT [PomBase:mah] synonym: "abolished histone lysine H4 K20 trimethylation" EXACT [GO:0034773, PomBase:mah] synonym: "histone H4-K20 trimethylation abolished" EXACT [PomBase:mah] synonym: "histone H4-K20 trimethylation absent" EXACT [PomBase:al] is_a: FYPO:0002565 ! abolished histone methylation is_a: FYPO:0004215 ! abnormal histone H4-K20 methylation is_a: FYPO:0004488 ! abolished protein lysine methylation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0034773 ! histone H4-K20 trimethylation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0034773 ! histone H4-K20 trimethylation created_by: midori creation_date: 2014-12-19T15:04:26Z [Term] id: FYPO:0004219 name: normal histone H4-K20 methylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which methylation of lysine at position 20 of histone H4 is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal histone H4 K20 methylation" EXACT [GO:0034470, PomBase:mah] synonym: "normal histone H4-K20 methylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal histone H4-K20 methylation during vegetative growth" EXACT [PomBase:mah] synonym: "normal histone H4K20me" EXACT [GO:0034770, PomBase:mah] synonym: "normal histone lysine H4 K20 methylation" EXACT [GO:0034770, PomBase:mah] is_a: FYPO:0000861 ! normal histone methylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034770 ! histone H4-K20 methylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034770 ! histone H4-K20 methylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-12-19T15:15:59Z [Term] id: FYPO:0004220 name: normal histone H4-K20 monomethylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which monomethylation of lysine at position 20 of histone H4 is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal histone H4 K20 monomethylation" EXACT [GO:0034471, PomBase:mah] synonym: "normal histone H4-K20 monomethylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal histone H4-K20 monomethylation during vegetative growth" EXACT [PomBase:mah] synonym: "normal histone H4K20me1" EXACT [PomBase:mah] synonym: "normal histone lysine H4 K20 monomethylation" EXACT [GO:0034771, PomBase:mah] is_a: FYPO:0004219 ! normal histone H4-K20 methylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034771 ! histone H4-K20 monomethylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034771 ! histone H4-K20 monomethylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-12-19T15:17:45Z [Term] id: FYPO:0004221 name: normal histone H4-K20 dimethylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which dimethylation of lysine at position 20 of histone H4 is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal histone H4 K20 dimethylation" EXACT [GO:0034472, PomBase:mah] synonym: "normal histone H4-K20 dimethylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal histone H4-K20 dimethylation during vegetative growth" EXACT [PomBase:mah] synonym: "normal histone H4K20me2" EXACT [PomBase:mah] synonym: "normal histone lysine H4 K20 dimethylation" EXACT [GO:0034772, PomBase:mah] is_a: FYPO:0004219 ! normal histone H4-K20 methylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034772 ! histone H4-K20 dimethylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034772 ! histone H4-K20 dimethylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-12-19T15:19:09Z [Term] id: FYPO:0004222 name: normal histone H4-K20 trimethylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which trimethylation of lysine at position 20 of histone H4 is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal histone H4 K20 trimethylation" EXACT [GO:0034473, PomBase:mah] synonym: "normal histone H4-K20 trimethylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal histone H4-K20 trimethylation during vegetative growth" EXACT [PomBase:mah] synonym: "normal histone H4K20me3" EXACT [PomBase:mah] synonym: "normal histone lysine H4 K20 trimethylation" EXACT [GO:0034773, PomBase:mah] is_a: FYPO:0004219 ! normal histone H4-K20 methylation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034773 ! histone H4-K20 trimethylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034773 ! histone H4-K20 trimethylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-12-19T15:20:23Z [Term] id: FYPO:0004223 name: increased H4-K20 monomethylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which monomethylation of lysine at position 20 of histone H4 occurs to a greater extent than normal." [PomBase:mah] synonym: "increased histone H4-K20 monomethylation" EXACT [GO:0034771, PomBase:mah] synonym: "increased histone H4-K20 monomethylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H4-K20 monomethylation during vegetative growth" EXACT [PomBase:mah] synonym: "increased histone H4K20me1" EXACT [PomBase:mah] synonym: "increased histone lysine H4-K20 monomethylation" EXACT [GO:0034771, PomBase:mah] is_a: FYPO:0000869 ! increased histone methylation is_a: FYPO:0004215 ! abnormal histone H4-K20 methylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034771 ! histone H4-K20 monomethylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034771 ! histone H4-K20 monomethylation created_by: midori creation_date: 2014-12-19T15:21:57Z [Term] id: FYPO:0004224 name: decreased H4-K20 trimethylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which trimethylation of lysine at position 20 of histone H4 occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased H4K20me3" EXACT [PomBase:mah] synonym: "decreased histone H4-K20 trimethylation" EXACT [GO:0034773, PomBase:mah] synonym: "decreased histone H4-K20 trimethylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H4-K20 trimethylation during vegetative growth" EXACT [PomBase:mah] synonym: "decreased histone lysine H4-K20 trimethylation" EXACT [GO:0034773, PomBase:mah] synonym: "reduced histone H4-K20 trimethylation" EXACT [PomBase:mah] is_a: FYPO:0000870 ! decreased histone methylation is_a: FYPO:0004215 ! abnormal histone H4-K20 methylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034773 ! histone H4-K20 trimethylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034773 ! histone H4-K20 trimethylation created_by: midori creation_date: 2014-12-19T15:22:07Z [Term] id: FYPO:0004225 name: abnormal nucleosome binding def: "A molecular function phenotype in which occurrence of nucleosome binding by a gene product (usually a protein) in a mutant is abnormal. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] is_a: FYPO:0002576 ! abnormal chromatin binding is_a: FYPO:0003591 ! abnormal protein complex binding intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0031491 ! nucleosome binding intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0031491 ! nucleosome binding relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-12-19T15:30:06Z [Term] id: FYPO:0004226 name: abolished nucleosome binding def: "A molecular function phenotype in which nucleosome binding by a gene product (usually a protein) in a mutant does not occur. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "nucleosome binding abolished" EXACT [PomBase:mah] is_a: FYPO:0000705 ! abolished protein binding is_a: FYPO:0001093 ! abolished chromatin binding is_a: FYPO:0004225 ! abnormal nucleosome binding intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0031491 ! nucleosome binding relationship: towards GO:0031491 ! nucleosome binding created_by: midori creation_date: 2014-12-19T15:30:10Z [Term] id: FYPO:0004227 name: decreased nucleosome binding def: "A molecular function phenotype in which occurrence of nucleosome binding by a gene product (usually a protein) in a mutant is decreased. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "reduced nucleosome binding" EXACT [PomBase:mah] is_a: FYPO:0001645 ! decreased protein binding is_a: FYPO:0002577 ! decreased chromatin binding is_a: FYPO:0004225 ! abnormal nucleosome binding intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0031491 ! nucleosome binding relationship: inheres_in GO:0031491 ! nucleosome binding created_by: midori creation_date: 2014-12-19T15:30:29Z [Term] id: FYPO:0004228 name: decreased protein phosphorylation during cellular response to UV def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal during a cellular response to ultraviolet light." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein phosphorylation during cellular response to ultraviolet light" EXACT [PomBase:mah] synonym: "decreased protein phosphorylation during cellular response to UV during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein phosphorylation during cellular response to UV during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein phosphorylation during cellular response to UV" EXACT [PomBase:mah] is_a: FYPO:0001838 ! decreased protein phosphorylation during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0034644 ! cellular response to UV intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0034644 ! cellular response to UV relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2014-12-19T15:34:43Z [Term] id: FYPO:0004229 name: normal growth during cellular response to ionizing radiation def: "A cell growth phenotype in which cell population growth is normal (i.e. indistinguishable from wild type) during a cellular response to ionizing radiation." [PomBase:mah] synonym: "normal cell population growth during cellular response to ionizing radiation" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cell population growth during cellular response to IR" EXACT [PomBase:mah] synonym: "normal cellular response to ionizing radiation" RELATED [PomBase:mah] synonym: "normal sensitivity to ionizing radiation" RELATED [PomBase:vw] synonym: "normal vegetative cell population growth during cellular response to ionizing radiation" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: happens_during GO:0071479 ! cellular response to ionizing radiation relationship: happens_during GO:0071479 ! cellular response to ionizing radiation created_by: midori creation_date: 2014-12-19T15:38:05Z [Term] id: FYPO:0004230 name: normal protein phosphorylation during cellular response to UV def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins is normal (i.e. indistinguishable from wild type) during a cellular response to ultraviolet light." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein phosphorylation during cellular response to ultraviolet light" RELATED [PomBase:mah] synonym: "normal protein phosphorylation during cellular response to UV during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein phosphorylation during cellular response to UV during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000776 ! normal protein phosphorylation during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0034644 ! cellular response to UV intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0034644 ! cellular response to UV relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2014-12-19T15:40:25Z [Term] id: FYPO:0004231 name: abnormal methylated histone binding def: "A molecular function phenotype in which occurrence of methylated histone binding by a gene product (usually a protein) in a mutant is abnormal. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] comment: This term can mean that the mutated gene product itself binds one or more methylated histone(s) differently from wild type, or that a mutation in one gene affects methylated histone binding by a second gene product. When using this term, it is therefore recommended to note the specific protein(s) affected. is_a: FYPO:0000704 ! abnormal protein binding intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0035064 ! methylated histone binding intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0035064 ! methylated histone binding relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2014-12-19T15:44:56Z [Term] id: FYPO:0004232 name: abolished methylated histone binding def: "A molecular function phenotype in which methylated histone binding by a gene product (usually a protein) in a mutant does not occur. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "methylated histone binding abolished" EXACT [PomBase:mah] is_a: FYPO:0000705 ! abolished protein binding is_a: FYPO:0004231 ! abnormal methylated histone binding intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0035064 ! methylated histone binding relationship: towards GO:0035064 ! methylated histone binding created_by: midori creation_date: 2014-12-19T15:45:21Z [Term] id: FYPO:0004233 name: decreased and delayed cell cycle arrest in mitotic G1 phase in response to nitrogen starvation def: "A cellular process phenotype in which cell cycle arrest in response to nitrogen starvation occurs in G1 phase, but its occurrence is decreased and begins later than normal." [PMID:21118960, PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "decreased and delayed cell cycle arrest in mitotic G1 phase during cellular response to nitrogen starvation" EXACT [PomBase:mah] synonym: "decreased and delayed cell cycle arrest in mitotic G1 phase in response to nitrogen depletion" EXACT [PomBase:vw] synonym: "decreased and delayed cell cycle arrest in mitotic G1 phase in response to nitrogen deprivation" EXACT [PomBase:vw] synonym: "decreased and delayed mitotic cell cycle arrest in G1 phase in response to nitrogen starvation" EXACT [PomBase:mah] synonym: "decreased and delayed mitotic G1 arrest in response to nitrogen starvation" EXACT [PomBase:mah] synonym: "decreased and delayed nitrogen deprivation-induced G1 arrest" EXACT [PomBase:vw] synonym: "reduced and delayed cell cycle arrest in mitotic G1 phase in response to nitrogen starvation" EXACT [PomBase:mah] is_a: FYPO:0000711 ! decreased cell cycle arrest in mitotic G1 phase in response to nitrogen starvation is_a: FYPO:0000712 ! delayed cell cycle arrest in mitotic G1 phase in response to nitrogen starvation created_by: midori creation_date: 2014-12-19T15:53:01Z [Term] id: FYPO:0004234 name: increased duration of mitosis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the duration of mitosis is increased." [PomBase:mah] synonym: "increased duration of mitosis during vegetative growth" EXACT [PomBase:mah] synonym: "increased duration of mitotic nuclear division" EXACT [GO:0007067] synonym: "prolonged mitosis" EXACT [PomBase:mah] is_a: FYPO:0000337 ! abnormal mitosis is_a: PATO:0000498 ! increased duration intersection_of: PATO:0000498 ! increased duration intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0007067 ! mitotic nuclear division relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0007067 ! mitotic nuclear division created_by: midori creation_date: 2014-12-19T15:56:30Z [Term] id: FYPO:0004235 name: normal RNA level oscillation during mitotic cell cycle def: "A gene expression phenotype in which RNA levels vary over the course of the mitotic cell cycle normally (i.e. levels are indistinguishable from wild type at any assayed point). Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [PMID:21118960, PomBase:mah] comment: We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "normal periodic expression of RNA during mitotic cell cycle" EXACT [PomBase:al] synonym: "normal RNA level fluctuation during mitotic cell cycle" EXACT [PomBase:mah] is_a: FYPO:0000257 ! normal phenotype is_a: FYPO:0001333 ! gene expression regulation phenotype during vegetative growth created_by: midori creation_date: 2014-12-19T16:08:33Z [Term] id: FYPO:0004236 name: thin mitotic spindle midzone def: "A spindle phenotype in which the mitotic spindle is not of uniform thickness, but instead the spindle midzone is thinner than normal." [PMID:17442892, PomBase:mah] synonym: "thin mitotic spindle midzone during vegetative growth" EXACT [PomBase:mah] synonym: "thin spindle midzone during mitosis" EXACT [PomBase:mah] is_a: FYPO:0001574 ! abnormal bipolar mitotic spindle is_a: FYPO:0003607 ! abnormal spindle morphology is_a: PATO:0000592 ! decreased thickness intersection_of: PATO:0000592 ! decreased thickness intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990023 ! mitotic spindle midzone relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990023 ! mitotic spindle midzone created_by: midori creation_date: 2014-12-19T16:21:43Z [Term] id: FYPO:0004237 name: increased protein localization to heterochromatin at centromere outer repeat def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to heterochromatin at centromere outer repeat regions of a chromosome is decreased." [PMID:20299449, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to heterochromatin at centromere otr" EXACT [PomBase:mah] synonym: "increased protein localisation to heterochromatin at centromere outer repeat" EXACT [PomBase:mah] synonym: "increased protein localisation to heterochromatin at centromeric outer repeat region" EXACT [PomBase:mah] synonym: "increased protein localisation to heterochromatin at pericentric region" RELATED [PomBase:mah] synonym: "increased protein localisation to heterochromatin at pericentromeric region" RELATED [PomBase:mah] synonym: "increased protein localization to heterochromatin at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein localization to heterochromatin at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001131 ! abnormal protein localization to heterochromatin during vegetative growth is_a: FYPO:0003009 ! increased protein localization to centromere outer repeat is_a: FYPO:0003011 ! increased protein localization to chromatin intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0097355 ! protein localization to heterochromatin intersection_of: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0097355 ! protein localization to heterochromatin relationship: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region created_by: midori creation_date: 2015-01-07T10:46:02Z [Term] id: FYPO:0004238 name: increased histone H3-K4 acetylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which acetylation of lysine at position 4 of histone H3 occurs to a greater extent than normal." [PomBase:mah] synonym: "increased histone H3-K4 acetylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H3-K4 acetylation during vegetative growth" EXACT [PomBase:mah] synonym: "increased histone H3K4 acetylation" EXACT [GO:0043973] is_a: FYPO:0002363 ! increased histone H3 acetylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0043973 ! histone H3-K4 acetylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0043973 ! histone H3-K4 acetylation created_by: midori creation_date: 2015-01-07T11:15:51Z [Term] id: FYPO:0004239 name: decreased histone H3-K4 acetylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which acetylation of lysine at position 4 of histone H3 occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased histone H3-K4 acetylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H3-K4 acetylation during vegetative growth" EXACT [PomBase:mah] synonym: "decreased histone H3K4 acetylation" EXACT [GO:0043973] synonym: "reduced histone H3-K4 acetylation" RELATED [PomBase:mah] is_a: FYPO:0002362 ! decreased histone H3 acetylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0043973 ! histone H3-K4 acetylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0043973 ! histone H3-K4 acetylation created_by: midori creation_date: 2015-01-07T11:17:08Z [Term] id: FYPO:0004240 name: decreased histone H3-K56 acetylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which acetylation of lysine at position 56 of histone H3 occurs to a lower extent than normal." [PomBase:mah] synonym: "decreased histone H3-56 acetylation during vegetative growth" EXACT [PomBase:mah] synonym: "decreased histone H3-K56 acetylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H3K56 acetylation" EXACT [PomBase:mah] synonym: "reduced histone H3-K56 acetylation" RELATED [PomBase:mah] is_a: FYPO:0002362 ! decreased histone H3 acetylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0097043 ! histone H3-K56 acetylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0097043 ! histone H3-K56 acetylation created_by: midori creation_date: 2015-01-07T11:18:00Z [Term] id: FYPO:0004241 name: decreased rate of DNA replication during cellular response to DNA damage def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the rate, or speed, of DNA replication is decreased during a cellular response to DNA damage." [PomBase:mah] synonym: "decreased rate of DNA replication during cellular response to DNA damage during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased rate of DNA replication during cellular response to DNA damage during vegetative growth" EXACT [PomBase:mah] synonym: "decreased rate of DNA replication in response to DNA damage" RELATED [PomBase:vw] synonym: "reduced rate of DNA replication during cellular response to DNA damage" EXACT [PomBase:mah] is_a: FYPO:0001982 ! decreased rate of DNA replication during vegetative growth intersection_of: PATO:0000911 ! decreased rate intersection_of: happens_during GO:0006974 ! cellular response to DNA damage stimulus intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902969 ! mitotic DNA replication relationship: happens_during GO:0006974 ! cellular response to DNA damage stimulus relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902969 ! mitotic DNA replication created_by: midori creation_date: 2015-01-07T11:21:55Z [Term] id: FYPO:0004242 name: decreased protein kinase activity during mitotic S phase def: "A molecular function phenotype in which the observed rate of a protein kinase activity is decreased during the S phase of the mitotic cell cycle." [PomBase:mah] synonym: "reduced protein kinase activity during mitotic S phase" EXACT [PomBase:mah] is_a: FYPO:0003331 ! decreased protein kinase activity during mitotic interphase intersection_of: PATO:0002052 ! decreased occurrence intersection_of: during GO:0000084 ! mitotic S phase intersection_of: inheres_in GO:0004672 ! protein kinase activity relationship: during GO:0000084 ! mitotic S phase relationship: inheres_in GO:0004672 ! protein kinase activity created_by: midori creation_date: 2015-01-07T11:52:30Z [Term] id: FYPO:0004243 name: decreased protein kinase activity during cellular response to DNA damage def: "A molecular function phenotype in which the observed rate of a protein kinase activity is decreased during a cellular response to DNA damage." [PomBase:mah] synonym: "decreased protein kinase activity in response to DNA damage" RELATED [PomBase:vw] synonym: "reduced protein kinase activity during cellular response to DNA damage" EXACT [PomBase:mah] is_a: FYPO:0001382 ! decreased protein kinase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: during GO:0006974 ! cellular response to DNA damage stimulus intersection_of: inheres_in GO:0004672 ! protein kinase activity relationship: during GO:0006974 ! cellular response to DNA damage stimulus relationship: inheres_in GO:0004672 ! protein kinase activity created_by: midori creation_date: 2015-01-07T12:02:39Z [Term] id: FYPO:0004244 name: decreased protein kinase activity during mitotic S phase during cellular response to DNA damage def: "A molecular function phenotype in which the observed rate of a protein kinase activity is decreased during S phase of the mitotic cell cycle during a cellular response to DNA damage." [PomBase:mah] synonym: "decreased protein kinase activity during mitotic S phase in response to DNA damage" RELATED [PomBase:vw] synonym: "reduced protein kinase activity during mitotic S phase during cellular response to DNA damage" EXACT [PomBase:mah] is_a: FYPO:0004242 ! decreased protein kinase activity during mitotic S phase is_a: FYPO:0004243 ! decreased protein kinase activity during cellular response to DNA damage intersection_of: PATO:0002052 ! decreased occurrence intersection_of: during GO:0000084 ! mitotic S phase intersection_of: during GO:0006974 ! cellular response to DNA damage stimulus intersection_of: inheres_in GO:0004672 ! protein kinase activity relationship: during GO:0000084 ! mitotic S phase relationship: during GO:0006974 ! cellular response to DNA damage stimulus relationship: inheres_in GO:0004672 ! protein kinase activity created_by: midori creation_date: 2015-01-07T12:03:45Z [Term] id: FYPO:0004245 name: normal protein kinase activity during mitotic S phase during cellular response to DNA damage def: "A molecular function phenotype in which the observed rate of a protein kinase activity is normal (i.e. indistinguishable from wild type) during S phase of the mitotic cell cycle during a cellular response to DNA damage." [PomBase:mah] synonym: "normal protein kinase activity during mitotic S phase in response to DNA damage" RELATED [PomBase:vw] is_a: FYPO:0003075 ! normal protein kinase activity intersection_of: PATO:0000001 ! quality intersection_of: during GO:0000084 ! mitotic S phase intersection_of: during GO:0006974 ! cellular response to DNA damage stimulus intersection_of: inheres_in GO:0004672 ! protein kinase activity intersection_of: qualifier PATO:0000461 ! normal relationship: during GO:0000084 ! mitotic S phase relationship: during GO:0006974 ! cellular response to DNA damage stimulus relationship: inheres_in GO:0004672 ! protein kinase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-01-07T12:10:54Z [Term] id: FYPO:0004246 name: abnormal microtubule cytoskeleton morphology during prophase I def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of the microtubule cytoskeleton is abnormal during prophase of the first meiotic nuclear division." [PMID:11907273, PomBase:mah] comment: Note that an abnormal microtubule cytoskeleton organization process may, but does not necessarily, result in abnormal microtubule cytoskeleton morphology. synonym: "abnormal microtubule cytoskeleton morphology during meiotic prophase I" EXACT [PomBase:mah] is_a: FYPO:0003064 ! abnormal microtubule cytoskeleton morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0007128 ! meiotic prophase I intersection_of: inheres_in GO:0015630 ! microtubule cytoskeleton intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0007128 ! meiotic prophase I relationship: inheres_in GO:0015630 ! microtubule cytoskeleton relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-01-07T12:18:35Z [Term] id: FYPO:0004247 name: normal vacuolar morphology during vegetative growth def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of the fungal-type vacuole is normal (i.e. indistinguishable from wild type).." [PomBase:mah] synonym: "normal vacuolar morphology during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001313 ! normal subcellular component during vegetative growth is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-01-07T13:07:33Z [Term] id: FYPO:0004248 name: normal protein localization to vacuolar membrane def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the vacuolar membrane is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to vacuolar membrane" EXACT [PomBase:mah] synonym: "normal protein localization in vacuolar membrane" EXACT [GO:1903778] synonym: "normal protein localization to vacuolar membrane during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to vacuolar membrane during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000644 ! normal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903778 ! protein localization to vacuolar membrane intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903778 ! protein localization to vacuolar membrane relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-01-07T13:16:32Z [Term] id: FYPO:0004249 name: abnormal protein localization to vacuolar membrane def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the vacuolar membrane is abnormal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to vacuolar membrane" EXACT [PomBase:mah] synonym: "abnormal protein localization in vacuolar membrane" EXACT [GO:1903778] synonym: "abnormal protein localization to vacuolar membrane during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein localization to vacuolar membrane during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000443 ! abnormal protein localization during vegetative growth is_a: FYPO:0001351 ! abnormal membrane organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1903778 ! protein localization to vacuolar membrane intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1903778 ! protein localization to vacuolar membrane relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-01-07T13:18:23Z [Term] id: FYPO:0004250 name: abolished protein localization to vacuolar membrane def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the vacuolar membrane is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to vacuolar membrane" EXACT [PomBase:mah] synonym: "abolished protein localization in vacuolar membrane" EXACT [GO:1903778] synonym: "abolished protein localization to vacuolar membrane during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to vacuolar membrane during vegetative growth" EXACT [PomBase:mah] synonym: "protein localization to vacuolar membrane abolished" EXACT [PomBase:mah] is_a: FYPO:0001179 ! protein localization abolished during vegetative growth is_a: FYPO:0004249 ! abnormal protein localization to vacuolar membrane intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1903778 ! protein localization to vacuolar membrane relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1903778 ! protein localization to vacuolar membrane created_by: midori creation_date: 2015-01-07T13:18:29Z [Term] id: FYPO:0004251 name: increased DNA resection during replication fork processing def: "A cell phenotype in which the extent of DNA resection upstream of a stalled replication fork is greater than normal. DNA resection is the 5'-to-3' degradation of one strand of DNA, leaving a stretch of single-stranded DNA." [PMID:20051983, PMID:24806966, PomBase:mah] synonym: "increased DNA resectioning during replication fork processing" EXACT [PomBase:amc] synonym: "increased extent of DNA resection during replication fork processing" EXACT [PomBase:mah] synonym: "increased extent of exonucleolytic DNA cleavage during replication fork processing" EXACT [PomBase:mah] is_a: FYPO:0003586 ! abnormal replication fork processing created_by: midori creation_date: 2015-01-07T14:13:46Z [Term] id: FYPO:0004252 name: normal regulation of DNA replication during replication fork arrest def: "A regulation phenotype observed in the vegetative growth phase of the life cycle in which regulation of DNA replication is normal (i.e. indistinguishable from wild type) when one or more replication forks arrest." [PMID:24806966, PomBase:mah] synonym: "normal regulation of DNA replication during replication fork arrest during mitotic cell cycle" EXACT [PomBase:mah] synonym: "normal regulation of DNA replication during replication fork arrest during vegetative growth" EXACT [PomBase:mah] synonym: "normal regulation of nuclear cell cycle DNA replication during replication fork arrest" EXACT [GO:0033262] is_a: FYPO:0002995 ! normal regulation of DNA replication intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0043111 ! replication fork arrest intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0033262 ! regulation of nuclear cell cycle DNA replication intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0043111 ! replication fork arrest relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0033262 ! regulation of nuclear cell cycle DNA replication relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-01-07T14:53:56Z [Term] id: FYPO:0004253 name: decreased nuclease activity def: "A molecular function phenotype in which the observed rate of a nuclease activity is decreased." [PomBase:mah] synonym: "reduced nuclease activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0003163 ! abnormal nuclease activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004518 ! nuclease activity relationship: inheres_in GO:0004518 ! nuclease activity created_by: midori creation_date: 2015-01-07T15:00:06Z [Term] id: FYPO:0004254 name: abnormal mitotic cell cycle regulation during cellular response to UV def: "A cellular response phenotype observed in the vegetative growth phase of the life cycle in which the regulation of the mitotic cell cycle in response to ultraviolet light (UV) is abnormal. Normally, cell cycle progression is slowed or arrested transiently following exposure to UV. The most common abnormality is for the cell cycle to progress as in the absence of UV exposure." [PomBase:mah] synonym: "abnormal cell cycle regulation during cellular response to UV" EXACT [PomBase:mah] synonym: "abnormal mitotic cell cycle delay following UV exposure" EXACT [PomBase:al] synonym: "abnormal mitotic cell cycle regulation during cellular response to ultraviolet light" EXACT [PomBase:mah] synonym: "abnormal mitotic cell cycle regulation in response to UV" EXACT [PomBase:mah] is_a: FYPO:0000148 ! abnormal regulation of mitotic cell cycle is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0034644 ! cellular response to UV intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0007346 ! regulation of mitotic cell cycle intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0034644 ! cellular response to UV relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0007346 ! regulation of mitotic cell cycle relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-01-07T15:01:50Z [Term] id: FYPO:0004255 name: inviable elongated mononucleate vegetative cell def: "A cell phenotype in which a cell contains one nucleus, is elongated, and is inviable." [PomBase:mah, PomBase:vw] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "inviable elongated mononucleate cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable elongated mononucleate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable long mononucleate vegetative cell" EXACT [PomBase:vw] synonym: "inviable vegetative elongated mononucleate cell" EXACT [PomBase:mah] is_a: FYPO:0001490 ! inviable elongated vegetative cell is_a: FYPO:0001916 ! elongated mononucleate vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000060 ! mononucleate vegetative cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000060 ! mononucleate vegetative cell relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2015-01-07T15:09:10Z [Term] id: FYPO:0004256 name: viable lemon-shaped cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a single cell is viable, and grows in the form of a lemon. A lemon shape is defined mathematically as having a quadric surface in three dimensions obtained by rotating less than half of a circular arc about an axis passing through the endpoints of the arc." [http://mathworld.wolfram.com/Lemon.html, PomBase:mah] synonym: "viable lemon-shaped cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "viable lemon-shaped cell during vegetative growth" EXACT [PomBase:mah] synonym: "viable lemon-shaped vegetative cell" EXACT [PomBase:mah] is_a: FYPO:0002197 ! viable vegetative cell with abnormal cell shape intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000224 ! lemon-shaped cell intersection_of: has_part FYPO:0001491 ! viable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000224 ! lemon-shaped cell relationship: has_part FYPO:0001491 ! viable vegetative cell created_by: midori creation_date: 2015-01-07T15:34:48Z [Term] id: FYPO:0004257 name: swollen multinucleate vegetative cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell contains more than one nucleus and has a larger volume than normal." [PMID:10503548, PomBase:mah] synonym: "enlarged multinucleate cell" RELATED [PomBase:mah] synonym: "large multinucleate cell" RELATED [PomBase:vw] synonym: "multinucleate cell with increased cell size" RELATED [PomBase:vw] synonym: "multinucleate cell with increased cell volume" EXACT [PomBase:mah] synonym: "swollen multinucleate cell during vegetative growth" EXACT [PomBase:mah] synonym: "swollen multinucleate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000025 ! swollen cell intersection_of: has_part FYPO:0000061 ! multinucleate vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000025 ! swollen cell relationship: has_part FYPO:0000061 ! multinucleate vegetative cell created_by: midori creation_date: 2015-01-07T15:46:08Z [Term] id: FYPO:0004258 name: decreased protein tyrosine phosphorylation during cellular response to hydroxyurea def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of tyrosine residues in one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal during a cellular response to hydroxyurea." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased peptidyl-tyrosine phosphorylation during cellular response to hydroxyurea" EXACT [GO:0018108, PomBase:mah] synonym: "decreased protein tyrosine phosphorylation during cellular response to HU" EXACT [PomBase:mah] synonym: "decreased protein tyrosine phosphorylation during cellular response to hydroxyurea during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein tyrosine phosphorylation during cellular response to hydroxyurea during vegetative growth" EXACT [PomBase:mah] synonym: "decreased tyrosine phosphorylation during cellular response to hydroxyurea" EXACT [PomBase:al] synonym: "reduced protein tyrosine phosphorylation during cellular response to hydroxyurea" EXACT [PomBase:mah] is_a: FYPO:0002098 ! decreased protein phosphorylation during cellular response to hydroxyurea is_a: FYPO:0002375 ! decreased protein tyrosine phosphorylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: happens_during GO:0072711 ! cellular response to hydroxyurea intersection_of: inheres_in GO:0018108 ! peptidyl-tyrosine phosphorylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: happens_during GO:0072711 ! cellular response to hydroxyurea relationship: inheres_in GO:0018108 ! peptidyl-tyrosine phosphorylation created_by: midori creation_date: 2015-01-07T15:58:13Z [Term] id: FYPO:0004259 name: abolished mitotic G2 DNA damage checkpoint def: "A cell cycle checkpoint phenotype in which cell cycle regulation mediated by the mitotic G2 DNA damage checkpoint does not occur under conditions that normally trigger the checkpoint signaling and response. Normally, the mitotic G2 DNA damage checkpoint negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GO:0007095, PMID:21098122, PomBase:mah] is_a: FYPO:0004373 ! abnormal mitotic G2 DNA damage checkpoint is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0007095 ! mitotic G2 DNA damage checkpoint relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0007095 ! mitotic G2 DNA damage checkpoint created_by: midori creation_date: 2015-01-07T16:18:15Z [Term] id: FYPO:0004260 name: increased duration of protein localization to double-strand break site def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a protein is localized to the region of a chromosome at which a DNA double-strand break has occurred for longer than normal." [PMID:21098122, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased duration of protein localisation to double-strand break site" EXACT [PomBase:mah] synonym: "increased duration of protein localization to double-strand break site during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased duration of protein localization to double-strand break site during vegetative growth" EXACT [PomBase:mah] synonym: "increased duration of protein localization to DSB site" EXACT [PomBase:al] synonym: "increased duration of protein localization to site of double-strand break" EXACT [GO:0035861, PomBase:mah] synonym: "prolonged protein localization to double-strand break site" EXACT [PomBase:mah] is_a: FYPO:0002473 ! abnormal protein localization to double-strand break site is_a: PATO:0000498 ! increased duration intersection_of: PATO:0000498 ! increased duration intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990166 ! protein localization to site of double-strand break relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990166 ! protein localization to site of double-strand break created_by: midori creation_date: 2015-01-07T16:34:48Z [Term] id: FYPO:0004261 name: decreased protein phosphorylation during mitotic G2 phase during cellular response to ionizing radiation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal during G2 phase of the mitotic cell cycle and during a cellular response to ionizing radiation." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein phosphorylation during cellular response to ionizing radiation during G2 phase of mitotic cell cycle" EXACT [PomBase:mah] synonym: "decreased protein phosphorylation during cellular response to ionizing radiation during mitotic G2 phase" EXACT [PomBase:mah] synonym: "decreased protein phosphorylation during mitotic G2 phase during cellular response to ionizing radiation during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein phosphorylation during mitotic G2 phase during cellular response to IR" EXACT [PomBase:mah] synonym: "reduced protein phosphorylation during cellular response to IR" EXACT [PomBase:mah] synonym: "reduced protein phosphorylation during mitotic G2 phase during cellular response to ionizing radiation" EXACT [PomBase:mah] is_a: FYPO:0002470 ! decreased protein phosphorylation during cellular response to ionizing radiation is_a: FYPO:0004111 ! decreased protein phosphorylation during mitotic G2 phase intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0000085 ! mitotic G2 phase intersection_of: happens_during GO:0071479 ! cellular response to ionizing radiation intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0000085 ! mitotic G2 phase relationship: happens_during GO:0071479 ! cellular response to ionizing radiation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2015-01-07T16:38:24Z [Term] id: FYPO:0004262 name: abolished protein phosphorylation during mitotic G2 phase during cellular response to ionizing radiation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, does not occur during G2 phase of the mitotic cell cycle and during a cellular response to ionizing radiation." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein phosphorylation during cellular response to ionizing radiation during G2 phase of mitotic cell cycle" EXACT [PomBase:mah] synonym: "abolished protein phosphorylation during cellular response to ionizing radiation during mitotic G2 phase" EXACT [PomBase:mah] synonym: "abolished protein phosphorylation during mitotic G2 phase during cellular response to ionizing radiation during vegetative growth" EXACT [PomBase:mah] synonym: "abolished protein phosphorylation during mitotic G2 phase during cellular response to IR" EXACT [PomBase:mah] synonym: "protein phosphorylation abolished during mitotic G2 phase during cellular response to ionizing radiation" EXACT [PomBase:mah] is_a: FYPO:0002471 ! abolished protein phosphorylation during cellular response to ionizing radiation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0000085 ! mitotic G2 phase intersection_of: during GO:0071479 ! cellular response to ionizing radiation intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0006468 ! protein phosphorylation relationship: during GO:0000085 ! mitotic G2 phase relationship: during GO:0071479 ! cellular response to ionizing radiation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2015-01-07T16:41:21Z [Term] id: FYPO:0004263 name: normal viability in stationary phase during nitrogen limitation def: "A cell population phenotype in which a normal proportion of the population remains viable after entering stationary phase, under conditions of nitrogen limitation, such as in a medium that contains a low level of NH4Cl and no other nitrogen source." [PomBase:mah] comment: Use this term if you have assayed growth of cells exposed to nitrogen limitation in culture. Note that nitrogen limitation differs from nitrogen starvation in that starvation results from complete absence of nitrogen, whereas limitation results from a shift from high to low nitrogen levels. synonym: "normal cell population viability in stationary phase during nitrogen limitation" EXACT [PomBase:mah] is_a: FYPO:0001310 ! normal viability in stationary phase created_by: midori creation_date: 2015-01-07T16:52:15Z [Term] id: FYPO:0004264 name: decreased cAMP-dependent protein kinase activity def: "A molecular function phenotype in which the observed rate of cAMP-dependent protein kinase activity is decreased." [PomBase:mah] synonym: "reduced cAMP-dependent protein kinase activity" EXACT [PomBase:mah] is_a: FYPO:0001382 ! decreased protein kinase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004691 ! cAMP-dependent protein kinase activity relationship: inheres_in GO:0004691 ! cAMP-dependent protein kinase activity created_by: midori creation_date: 2015-01-07T16:56:02Z [Term] id: FYPO:0004265 name: abnormal protein localization to cortical microtubule cytoskeleton def: "A cell phenotype in which the localization of a protein to the cortical microtubule cytoskeleton is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found associated with the cortical microtubule cytoskeleton and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to cortical microtubule cytoskeleton" EXACT [PomBase:mah] is_a: FYPO:0004090 ! abnormal protein localization to microtubule cytoskeleton intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0072699 ! protein localization to cortical microtubule cytoskeleton intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0072699 ! protein localization to cortical microtubule cytoskeleton relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-01-14T12:28:35Z [Term] id: FYPO:0004266 name: abolished protein localization to cortical microtubule cytoskeleton def: "A cell phenotype in which the localization of a protein to the cortical microtubule cytoskeleton does not occur." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to cortical microtubule cytoskeleton" EXACT [PomBase:mah] synonym: "protein absent from cortical microtubule cytoskeleton" RELATED [PomBase:mah] synonym: "protein localization to cortical microtubule cytoskeleton abolished" EXACT [PomBase:mah] is_a: FYPO:0004091 ! abolished protein localization to microtubule cytoskeleton is_a: FYPO:0004265 ! abnormal protein localization to cortical microtubule cytoskeleton intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0072699 ! protein localization to cortical microtubule cytoskeleton relationship: towards GO:0072699 ! protein localization to cortical microtubule cytoskeleton created_by: midori creation_date: 2015-01-14T12:34:09Z [Term] id: FYPO:0004267 name: normal septum disassembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which primary cell septum disassembly is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal septum disassembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal septum disassembly during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001319 ! normal cellular process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0030994 ! primary cell septum disassembly intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0030994 ! primary cell septum disassembly relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-01-14T12:55:16Z [Term] id: FYPO:0004268 name: decreased septum disassembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of septum disassembly is decreased." [PomBase:mah] synonym: "decreased septum disassembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased septum disassembly during vegetative growth" EXACT [PomBase:mah] synonym: "reduced septum disassembly" EXACT [PomBase:mah] is_a: FYPO:0000132 ! abnormal septum disassembly is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0030994 ! primary cell septum disassembly relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0030994 ! primary cell septum disassembly created_by: midori creation_date: 2015-01-14T13:09:37Z [Term] id: FYPO:0004269 name: abnormal cell septum edging catabolic process def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the dissolution of the cell septum edging material is abnormal; may result in the formation of chains of attached cells." [PomBase:mah] synonym: "abnormal cell septum edging catabolic process during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal cell septum edging catabolic process during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal cell septum edging catabolism" EXACT [PomBase:mah] synonym: "abnormal cell septum edging hydrolysis" EXACT [GO:0030995] synonym: "chained cells" RELATED [PomBase:mah] is_a: FYPO:0001353 ! abnormal cellular component organization during vegetative growth is_a: FYPO:0001363 ! abnormal metabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0030995 ! cell septum edging catabolic process intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0030995 ! cell septum edging catabolic process relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-01-14T13:18:47Z [Term] id: FYPO:0004270 name: decreased cell septum edging catabolic process def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the dissolution of the cell septum edging material is decreased." [PomBase:mah] synonym: "decreased cell septum edging catabolic process during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cell septum edging catabolic process during vegetative growth" EXACT [PomBase:mah] synonym: "decreased cell septum edging hydrolysis" EXACT [GO:030995] synonym: "reduced cell septum edging catabolic process" EXACT [PomBase:mah] is_a: FYPO:0004269 ! abnormal cell septum edging catabolic process is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0030995 ! cell septum edging catabolic process relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0030995 ! cell septum edging catabolic process created_by: midori creation_date: 2015-01-14T13:18:53Z [Term] id: FYPO:0004271 name: normal cell septum edging catabolic process def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the dissolution of the cell septum edging material is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cell septum edging catabolic process during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cell septum edging catabolic process during vegetative growth" EXACT [PomBase:mah] synonym: "normal cell septum edging catabolism" EXACT [PomBase:mah] synonym: "normal cell septum edging hydrolysis" EXACT [GO:0030995] is_a: FYPO:0000859 ! normal metabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0030995 ! cell septum edging catabolic process intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0030995 ! cell septum edging catabolic process relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-01-14T13:22:29Z [Term] id: FYPO:0004272 name: abnormal ascospore release from ascus def: "A cellular process phenotype in which ascospore release from an ascus is abnormal." [GO:0071998, PomBase:mah] is_a: FYPO:0000679 ! developmental process phenotype is_a: FYPO:0002739 ! abnormal meiotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0071998 ! ascospore release from ascus intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0071998 ! ascospore release from ascus relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-01-14T13:27:27Z [Term] id: FYPO:0004273 name: decreased ascospore release from ascus def: "A cellular process phenotype in which the occurrence of ascospore release from an ascus is decreased." [GO:0071998, PomBase:mah] synonym: "reduced ascospore release from ascus" EXACT [PomBase:mah] is_a: FYPO:0004272 ! abnormal ascospore release from ascus is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0071998 ! ascospore release from ascus relationship: inheres_in GO:0071998 ! ascospore release from ascus created_by: midori creation_date: 2015-01-14T13:27:37Z [Term] id: FYPO:0004274 name: abolished ascospore release from ascus def: "A cellular process phenotype in which ascospore release from an ascus does not occur." [GO:0071998, PomBase:mah] synonym: "absent ascospore release from ascus" EXACT [PomBase:mah] synonym: "ascospore release from ascus abolished" EXACT [PomBase:mah] is_a: FYPO:0004272 ! abnormal ascospore release from ascus is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0071998 ! ascospore release from ascus relationship: towards GO:0071998 ! ascospore release from ascus created_by: midori creation_date: 2015-01-14T13:27:37Z [Term] id: FYPO:0004275 name: abnormal positive regulation of transcription during G0 phase def: "A transcription regulation phenotype in which any process of positive regulation of transcription is abnormal during G0 phase." [PomBase:mah] synonym: "abnormal activation of gene-specific transcription during G0 phase" RELATED [GO:0045893, PomBase:mah] synonym: "abnormal activation of transcription, DNA-dependent, during G0 phase" NARROW [GO:0045893, PomBase:mah] synonym: "abnormal positive regulation of cellular transcription, DNA-dependent, during G0 phase" EXACT [GO:0045893, PomBase:mah] synonym: "abnormal positive regulation of gene-specific transcription during G0 phase" RELATED [GO:0045893, PomBase:mah] synonym: "abnormal positive regulation of transcription, DNA-dependent, during G0 phase" EXACT [GO:0045893, PomBase:mah] synonym: "abnormal stimulation of gene-specific transcription during G0 phase" NARROW [GO:0045893, PomBase:mah] synonym: "abnormal stimulation of transcription, DNA-dependent, during G0 phase" NARROW [GO:0045893, PomBase:mah] synonym: "abnormal up regulation of gene-specific transcription during G0 phase" RELATED [GO:0045893, PomBase:mah] synonym: "abnormal up regulation of transcription, DNA-dependent, during G0 phase" EXACT [GO:0045893, PomBase:mah] synonym: "abnormal up-regulation of gene-specific transcription during G0 phase" RELATED [GO:0045893, PomBase:mah] synonym: "abnormal up-regulation of transcription, DNA-dependent during G0 phase" EXACT [GO:0045893, PomBase:mah] synonym: "abnormal upregulation of gene-specific transcription during G0 phase" RELATED [GO:0045893, PomBase:mah] synonym: "abnormal upregulation of transcription, DNA-dependent, during G0 phase" EXACT [GO:0045893, PomBase:mah] is_a: FYPO:0000623 ! abnormal positive regulation of transcription is_a: FYPO:0004526 ! abnormal regulation of transcription intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0044838 ! cell quiescence intersection_of: inheres_in_part_of GO:0045893 ! positive regulation of transcription, DNA-templated intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0044838 ! cell quiescence relationship: inheres_in_part_of GO:0045893 ! positive regulation of transcription, DNA-templated relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-01-14T13:32:28Z [Term] id: FYPO:0004276 name: abnormal negative regulation of transcription during G0 phase def: "A transcription regulation phenotype in which any process of negative regulation of transcription is abnormal during G0 phase." [PomBase:mah] synonym: "abnormal down regulation of gene-specific transcription during G0 phase" RELATED [GO:0045892, PomBase:mah] synonym: "abnormal down regulation of transcription, DNA-dependent, during G0 phase" EXACT [GO:0045892, PomBase:mah] synonym: "abnormal down-regulation of gene-specific transcription during G0 phase" RELATED [GO:0045892, PomBase:mah] synonym: "abnormal down-regulation of transcription, DNA-dependent, during G0 phase" EXACT [GO:0045892, PomBase:mah] synonym: "abnormal downregulation of gene-specific transcription during G0 phase" RELATED [GO:0045892, PomBase:mah] synonym: "abnormal downregulation of transcription, DNA-dependent, during G0 phase" EXACT [GO:0045892, PomBase:mah] synonym: "abnormal inhibition of gene-specific transcription during G0 phase" RELATED [GO:0045892, PomBase:mah] synonym: "abnormal inhibition of transcription, DNA-dependent, during G0 phase" NARROW [GO:0045892, PomBase:mah] synonym: "abnormal negative regulation of cellular transcription, DNA-dependent, during G0 phase" EXACT [GO:0045892, PomBase:mah] synonym: "abnormal negative regulation of gene-specific transcription during G0 phase" RELATED [GO:0045892, PomBase:mah] synonym: "abnormal negative regulation of transcription, DNA-dependent, during G0 phase" EXACT [GO:0045892, PomBase:mah] is_a: FYPO:0004526 ! abnormal regulation of transcription intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0044838 ! cell quiescence intersection_of: inheres_in_part_of GO:0045892 ! negative regulation of transcription, DNA-templated intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0044838 ! cell quiescence relationship: inheres_in_part_of GO:0045892 ! negative regulation of transcription, DNA-templated relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-01-14T13:34:50Z [Term] id: FYPO:0004277 name: abnormal uracil DNA N-glycosylase activity def: "A molecular function phenotype in which the observed rate of uracil DNA N-glycosylase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004844 ! uracil DNA N-glycosylase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004844 ! uracil DNA N-glycosylase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-01-14T13:44:14Z [Term] id: FYPO:0004278 name: decreased uracil DNA N-glycosylase activity def: "A molecular function phenotype in which the observed rate of uracil DNA N-glycosylase activity is decreased." [PomBase:mah] synonym: "reduced uracil DNA N-glycosylase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0004277 ! abnormal uracil DNA N-glycosylase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004844 ! uracil DNA N-glycosylase activity relationship: inheres_in GO:0004844 ! uracil DNA N-glycosylase activity created_by: midori creation_date: 2015-01-14T13:44:21Z [Term] id: FYPO:0004279 name: abnormal hypoxanthine DNA N-glycosylase activity def: "A molecular function phenotype in which the observed rate of hypoxanthine DNA N-glycosylase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0097507 ! hypoxanthine DNA N-glycosylase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0097507 ! hypoxanthine DNA N-glycosylase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-01-14T13:46:33Z [Term] id: FYPO:0004280 name: decreased hypoxanthine DNA N-glycosylase activity def: "A molecular function phenotype in which the observed rate of hypoxanthine DNA N-glycosylase activity is decreased." [PomBase:mah] synonym: "reduced hypoxanthine DNA N-glycosylase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0004279 ! abnormal hypoxanthine DNA N-glycosylase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0097507 ! hypoxanthine DNA N-glycosylase activity relationship: inheres_in GO:0097507 ! hypoxanthine DNA N-glycosylase activity created_by: midori creation_date: 2015-01-14T13:46:42Z [Term] id: FYPO:0004281 name: abnormal xanthine DNA N-glycosylase activity def: "A molecular function phenotype in which the observed rate of xanthine DNA N-glycosylase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0097508 ! xanthine DNA N-glycosylase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0097508 ! xanthine DNA N-glycosylase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-01-14T13:47:41Z [Term] id: FYPO:0004282 name: decreased xanthine DNA N-glycosylase activity def: "A molecular function phenotype in which the observed rate of xanthine DNA N-glycosylase activity is decreased." [PomBase:mah] synonym: "reduced xanthine DNA N-glycosylase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0004281 ! abnormal xanthine DNA N-glycosylase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0097508 ! xanthine DNA N-glycosylase activity relationship: inheres_in GO:0097508 ! xanthine DNA N-glycosylase activity created_by: midori creation_date: 2015-01-14T13:47:45Z [Term] id: FYPO:0004283 name: abnormal oxanine DNA N-glycosylase activity def: "A molecular function phenotype in which the observed rate of oxanine DNA N-glycosylase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0097509 ! oxanine DNA N-glycosylase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0097509 ! oxanine DNA N-glycosylase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-01-14T13:48:23Z [Term] id: FYPO:0004284 name: decreased oxanine DNA N-glycosylase activity def: "A molecular function phenotype in which the observed rate of oxanine DNA N-glycosylase activity is decreased." [PomBase:mah] synonym: "reduced oxanine DNA N-glycosylase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0004283 ! abnormal oxanine DNA N-glycosylase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0097509 ! oxanine DNA N-glycosylase activity relationship: inheres_in GO:0097509 ! oxanine DNA N-glycosylase activity created_by: midori creation_date: 2015-01-14T13:48:26Z [Term] id: FYPO:0004285 name: normal growth on mitomycin C def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing mitomycin C." [PomBase:mah] synonym: "normal cell population growth in presence of mitomycin C" EXACT [PomBase:mah] synonym: "normal cell population growth on mitomycin C" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal vegetative cell population growth on mitomycin C" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:27504 ! mitomycin C relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:27504 ! mitomycin C created_by: midori creation_date: 2015-01-14T14:04:16Z [Term] id: FYPO:0004286 name: normal double-strand break repair via nonhomologous end joining def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of double-strand break repair via nonhomologous end joining (NHEJ) is normal (i.e. indistinguishable from wild type). NHEJ is the repair of double-strand breaks in DNA in which the two broken ends are rejoined with little or no sequence complementarity." [GO:0006303, PomBase:mah] synonym: "normal double-strand break repair via nonhomologous end joining during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal double-strand break repair via nonhomologous end joining during vegetative growth" EXACT [PomBase:mah] synonym: "normal NHEJ" EXACT [GO:0006303] synonym: "normal nonhomologous end joining" EXACT [PomBase:mah] is_a: FYPO:0001033 ! normal double-strand break repair intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006303 ! double-strand break repair via nonhomologous end joining intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006303 ! double-strand break repair via nonhomologous end joining relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-01-14T14:06:23Z [Term] id: FYPO:0004287 name: decreased double-strand break repair via nonhomologous end joining def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of double-strand break repair via nonhomologous end joining (NHEJ) is decreased. NHEJ is the repair of double-strand breaks in DNA in which the two broken ends are rejoined with little or no sequence complementarity." [GO:0006303, PomBase:mah] synonym: "decreased double-strand break repair via nonhomologous end joining during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased double-strand break repair via nonhomologous end joining during vegetative growth" EXACT [PomBase:mah] synonym: "decreased NHEJ" EXACT [GO:0006303] synonym: "decreased nonhomologous end joining" EXACT [PomBase:mah] synonym: "reduced double-strand break repair via nonhomologous end joining" EXACT [PomBase:mah] is_a: FYPO:0003660 ! decreased double-strand break repair intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006303 ! double-strand break repair via nonhomologous end joining relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006303 ! double-strand break repair via nonhomologous end joining created_by: midori creation_date: 2015-01-14T14:07:13Z [Term] id: FYPO:0004288 name: decreased GT repeat stability def: "A cell phenotype in which the number of GT dinucleotide microsatellite repeats present in a sequence varies more than normal." [PMID:18062930, PomBase:al, PomBase:mah] synonym: "decreased GT dinucleotide repeat stability" EXACT [SO:0001862] synonym: "decreased GT microsatellite repeat stability" EXACT [PMID:18062930] synonym: "reduced GT repeat stability" EXACT [PomBase:mah] is_a: FYPO:0001320 ! vegetative cell phenotype is_a: FYPO:0003037 ! abnormal cell phenotype created_by: midori creation_date: 2015-01-14T14:09:12Z [Term] id: FYPO:0004289 name: decreased GU repeat RNA binding def: "A molecular function phenotype in which occurrence of RNA binding to GU repeat regions by a gene product is decreased, when a gene or the bound RNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "reduced GU repeat RNA binding" EXACT [PomBase:mah] is_a: FYPO:0002132 ! abnormal RNA binding created_by: midori creation_date: 2015-01-14T14:25:05Z [Term] id: FYPO:0004290 name: decreased microsatellite DNA binding def: "A molecular function phenotype in which occurrence of DNA binding at microsatellite repeat regions by a gene product is decreased, when a gene or the bound DNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "decreased microsatellite repeat binding" EXACT [PomBase:mah] synonym: "reduced microsatellite DNA binding" EXACT [PomBase:mah] is_a: FYPO:0000658 ! decreased DNA binding intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0035939 ! microsatellite binding relationship: inheres_in GO:0035939 ! microsatellite binding created_by: midori creation_date: 2015-01-14T14:30:06Z [Term] id: FYPO:0004291 name: decreased GT microsatellite DNA binding def: "A molecular function phenotype in which occurrence of DNA binding at GT dinucleotide microsatellite repeat regions by a gene product is decreased, when a gene or the bound DNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "decreased GT dinucleotide microsatellite repeat binding" EXACT [PomBase:mah, SO:0001862] synonym: "decreased microsatellite (GT) DNA binding" EXACT [PomBase:al] synonym: "reduced GT microsatellite DNA binding" EXACT [PomBase:mah] is_a: FYPO:0004290 ! decreased microsatellite DNA binding created_by: midori creation_date: 2015-01-14T14:31:59Z [Term] id: FYPO:0004292 name: abnormal septum def: "A physical cellular phenotype in which the position or morphology of all or part of the septum is abnormal." [PomBase:mah] comment: Note that an abnormal septum organization process may, but does not necessarily, result in a physically abnormal septum. synonym: "abnormal septum physical object quality" EXACT [PomBase:mah] is_a: FYPO:0000287 ! abnormal subcellular component intersection_of: PATO:0001241 ! physical object quality intersection_of: inheres_in GO:0000935 ! barrier septum intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0000935 ! barrier septum relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-01-14T14:54:41Z [Term] id: FYPO:0004293 name: mislocalized septum def: "A physical cellular phenotype in which a cell has a septum in an abnormal location. The normal location is at the midpoint of the long axis of the cell." [PomBase:mah] comment: Note that the location of the septum is determined by the location of the contractile ring, which in turn is determined by the location of the cell division site, so an abnormality in cell division site determination can be inferred from this phenotype. synonym: "abnormal septum localization" RELATED [PomBase:mah] synonym: "abnormal septum location" EXACT [PomBase:mah] synonym: "abnormal septum position" EXACT [PomBase:mah] synonym: "abnormal septum positioning" RELATED [PomBase:mah] synonym: "asymmetric septum" EXACT [PomBase:mah] synonym: "asymmetrically located septum" EXACT [PomBase:mah] synonym: "mislocalised septum" EXACT [PomBase:mah] synonym: "misplaced septum" EXACT [PomBase:vw] is_a: FYPO:0004292 ! abnormal septum is_a: PATO:0000628 ! mislocalised intersection_of: PATO:0000628 ! mislocalised intersection_of: inheres_in GO:0000935 ! barrier septum relationship: inheres_in GO:0000935 ! barrier septum created_by: midori creation_date: 2015-01-14T14:55:00Z [Term] id: FYPO:0004294 name: mislocalized septum in stationary phase def: "A cell phenotype in which a cell has a septum in an abnormal location when the population in which the cell is found is in stationary phase." [PomBase:mah] synonym: "abnormal septum localization in stationary phase" RELATED [PomBase:mah] synonym: "abnormal septum location in stationary phase" EXACT [PomBase:mah] synonym: "abnormal septum position in stationary phase" EXACT [PomBase:mah] synonym: "abnormal septum positioning in stationary phase" RELATED [PomBase:mah] synonym: "asymmetric septum in stationary phase" EXACT [PomBase:mah] synonym: "asymmetrically located septum in stationary phase" EXACT [PomBase:mah] synonym: "mislocalised septum in stationary phase" EXACT [PomBase:mah] synonym: "misplaced septum in stationary phase" EXACT [PomBase:vw] is_a: FYPO:0004293 ! mislocalized septum created_by: midori creation_date: 2015-01-14T15:03:00Z [Term] id: FYPO:0004295 name: multiseptate cell def: "A physical cellular phenotype characterized by the presence of more than one septum in a cell." [PomBase:mah] is_a: FYPO:0000287 ! abnormal subcellular component is_a: FYPO:0004296 ! septated cell is_a: FYPO:0004639 ! abnormal cellular physical quality phenotype during vegetative growth is_a: PATO:0002002 ! has extra parts of type intersection_of: PATO:0002002 ! has extra parts of type intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards GO:0000935 ! barrier septum relationship: inheres_in CL:0000000 ! cell relationship: towards GO:0000935 ! barrier septum created_by: midori creation_date: 2015-01-14T15:06:08Z [Term] id: FYPO:0004296 name: septated cell def: "A physical cellular phenotype in which the cell contains one or more septa." [PomBase:mah] synonym: "septum present" EXACT [PomBase:mah] is_a: FYPO:0001321 ! cellular physical quality phenotype during vegetative growth intersection_of: FYPO:0001321 ! cellular physical quality phenotype during vegetative growth intersection_of: inheres_in CL:0000000 ! cell intersection_of: qualifier PATO:0000467 ! present intersection_of: towards GO:0000935 ! barrier septum relationship: inheres_in CL:0000000 ! cell relationship: qualifier PATO:0000467 ! present relationship: towards GO:0000935 ! barrier septum created_by: midori creation_date: 2015-01-14T15:10:27Z [Term] id: FYPO:0004297 name: multiseptate cell in stationary phase def: "A cell phenotype in which a cell contains more than one septum when the population in which the cell is found is in stationary phase." [PomBase:mah] is_a: FYPO:0004295 ! multiseptate cell created_by: midori creation_date: 2015-01-14T15:15:18Z [Term] id: FYPO:0004298 name: abnormal polynucleotide 5'-phosphatase activity def: "A molecular function phenotype in which the observed rate of polynucleotide 5'-phosphatase activity is abnormal." [PomBase:mah] is_a: FYPO:0004302 ! abnormal phosphatase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004651 ! polynucleotide 5'-phosphatase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004651 ! polynucleotide 5'-phosphatase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-01-14T15:27:37Z [Term] id: FYPO:0004299 name: abolished polynucleotide 5'-phosphatase activity def: "A molecular function phenotype in which polynucleotide 5'-phosphatase activity is absent." [PomBase:mah] synonym: "polynucleotide 5'-phosphatase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0004298 ! abnormal polynucleotide 5'-phosphatase activity is_a: FYPO:0004303 ! abolished phosphatase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0004651 ! polynucleotide 5'-phosphatase activity relationship: towards GO:0004651 ! polynucleotide 5'-phosphatase activity created_by: midori creation_date: 2015-01-14T15:27:43Z [Term] id: FYPO:0004300 name: normal ATPase activity def: "A molecular function phenotype in which the observed rate of an ATPase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0016887 ! ATPase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0016887 ! ATPase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-01-14T15:34:37Z [Term] id: FYPO:0004301 name: normal mitotic sister chromatid separation def: "A cellular process phenotype in which mitotic sister chromatid separation is normal (i.e. indistinguishable from wild type). Mitotic sister chromatid separation is the process in which sister chromatids are physically detached from each other during mitosis." [GO:0051306, PomBase:mah] synonym: "normal mitotic chromosome separation" EXACT [PomBase:mah] synonym: "normal mitotic sister chromatid separation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002741 ! normal mitotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051306 ! mitotic sister chromatid separation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051306 ! mitotic sister chromatid separation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-01-14T15:40:03Z [Term] id: FYPO:0004302 name: abnormal phosphatase activity def: "A molecular function phenotype in which the observed rate of a phosphatase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0016791 ! phosphatase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0016791 ! phosphatase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-01-14T15:47:31Z [Term] id: FYPO:0004303 name: abolished phosphatase activity def: "A molecular function phenotype in which a phosphatase activity is absent." [PomBase:mah] synonym: "phosphatase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0004302 ! abnormal phosphatase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0016791 ! phosphatase activity relationship: towards GO:0016791 ! phosphatase activity created_by: midori creation_date: 2015-01-14T15:47:36Z [Term] id: FYPO:0004304 name: decreased phosphatase activity def: "A molecular function phenotype in which the observed rate of a phosphatase activity is decreased." [PomBase:mah] synonym: "reduced phosphatase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0004302 ! abnormal phosphatase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0016791 ! phosphatase activity relationship: inheres_in GO:0016791 ! phosphatase activity created_by: midori creation_date: 2015-01-14T15:47:44Z [Term] id: FYPO:0004305 name: abnormal CTD phosphatase activity def: "A molecular function phenotype in which the observed rate of CTD phosphatase activity is abnormal." [PomBase:mah] is_a: FYPO:0001756 ! abnormal protein phosphatase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0008420 ! CTD phosphatase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0008420 ! CTD phosphatase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-01-14T15:49:49Z [Term] id: FYPO:0004306 name: decreased CTD phosphatase activity def: "A molecular function phenotype in which the observed rate of CTD phosphatase activity is decreased." [PomBase:mah] synonym: "reduced CTD phosphatase activity" EXACT [PomBase:mah] is_a: FYPO:0001757 ! decreased protein phosphatase activity is_a: FYPO:0004305 ! abnormal CTD phosphatase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0008420 ! CTD phosphatase activity relationship: inheres_in GO:0008420 ! CTD phosphatase activity created_by: midori creation_date: 2015-01-14T15:50:09Z [Term] id: FYPO:0004307 name: long mitotic spindle during metaphase def: "A spindle phenotype in which the mitotic spindle is longer than normal during metaphase." [PMID:10398680, PomBase:mah] synonym: "elongated mitotic spindle during metaphase" EXACT [PomBase:mah] synonym: "increased mitotic spindle length during metaphase" EXACT [PomBase:vw] synonym: "long bipolar mitotic spindle during metaphase" EXACT [PomBase:vw] synonym: "long mitotic spindle during metaphase during vegetative growth" EXACT [PomBase:mah] synonym: "long mitotic spindles during metaphase" EXACT [PomBase:mah] synonym: "long spindle during metaphase of mitosis" EXACT [PomBase:mah] synonym: "long spindle during mitotic metaphase" EXACT [PomBase:mah] is_a: FYPO:0000733 ! long mitotic spindle intersection_of: PATO:0000573 ! increased length intersection_of: exists_during GO:0000089 ! mitotic metaphase intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072686 ! mitotic spindle relationship: exists_during GO:0000089 ! mitotic metaphase relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072686 ! mitotic spindle created_by: midori creation_date: 2015-01-14T16:46:02Z [Term] id: FYPO:0004308 name: abnormal CENP-A containing chromatin organization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which CENP-A-containing chromatin organization is abnormal." [GO:0061641, PMID:9230309, PomBase:mah, PomBase:vw] synonym: "abnormal CENP-A containing chromatin organization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal CENP-A containing chromatin organization during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal chromatin organization at centromere central core " RELATED [PomBase:vw] is_a: FYPO:0001352 ! abnormal chromatin organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0061641 ! CENP-A containing chromatin organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0061641 ! CENP-A containing chromatin organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-01-14T17:08:06Z [Term] id: FYPO:0004309 name: delayed mitotic anaphase B def: "A cellular process phenotype in which anaphase B of mitosis begins later than normal. Anaphase B is the mitotic cell cycle phase during which the polar microtubules elongate and the two poles of the spindle move farther apart." [GO:0000092, PomBase:mah] synonym: "delayed mitotic anaphase B during vegetative growth" EXACT [PomBase:mah] synonym: "delayed onset of mitotic anaphase " EXACT [PomBase:mah] synonym: "mitotic anaphase B delay" EXACT [PomBase:mah] is_a: FYPO:0000616 ! abnormal mitotic anaphase progression is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000092 ! mitotic anaphase B relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000092 ! mitotic anaphase B created_by: midori creation_date: 2015-01-19T11:24:09Z [Term] id: FYPO:0004310 name: normal duration of mitotic M phase def: "A cell cycle phenotype in the duration of M phase of the mitotic cell cycle is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0002740 ! normal mitotic cell cycle phase is_a: PATO:0001309 ! duration intersection_of: PATO:0001309 ! duration intersection_of: inheres_in GO:0000087 ! mitotic M phase intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0000087 ! mitotic M phase relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-01-19T11:37:06Z [Term] id: FYPO:0004311 name: abnormal protein localization to CENP-A containing chromatin def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to CENP-A containing chromatin is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found associated with heterochromatin and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to CENP-A containing chromatin" EXACT [PomBase:mah] synonym: "abnormal protein localization to CENP-A containing chromatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein localization to CENP-A containing chromatin during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal protein localization to centromeric core region chromatin" EXACT [GO:0061638] is_a: FYPO:0000449 ! abnormal protein localization to centromere is_a: FYPO:0000452 ! abnormal protein localization to chromatin during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0061644 ! protein localization to CENP-A containing chromatin intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0061644 ! protein localization to CENP-A containing chromatin relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-01-19T11:48:30Z [Term] id: FYPO:0004312 name: abolished protein localization to CENP-A containing chromatin def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to CENP-A containing chromatin is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to CENP-A containing chromatin" EXACT [PomBase:mah] synonym: "abolished protein localization to CENP-A containing chromatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to CENP-A containing chromatin during vegetative growth" EXACT [PomBase:mah] synonym: "abolished protein localization to centromeric core region chromatin" EXACT [GO:0061638] synonym: "protein localization to CENP-A containing chromatin abolished" EXACT [PomBase:mah] is_a: FYPO:0000634 ! abolished protein localization to centromere is_a: FYPO:0001508 ! abolished protein localization to chromatin during vegetative growth is_a: FYPO:0004311 ! abnormal protein localization to CENP-A containing chromatin intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0061644 ! protein localization to CENP-A containing chromatin relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0061644 ! protein localization to CENP-A containing chromatin created_by: midori creation_date: 2015-01-19T11:49:05Z [Term] id: FYPO:0004313 name: decreased protein localization to CENP-A containing chromatin def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to CENP-A containing chromatin is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to CENP-A containing chromatin" EXACT [PomBase:mah] synonym: "decreased protein localization to CENP-A containing chromatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to CENP-A containing chromatin during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein localization to centromeric core region chromatin" EXACT [GO:0061638] synonym: "reduced protein localization to CENP-A containing chromatin" EXACT [PomBase:mah] is_a: FYPO:0000450 ! decreased protein localization to centromere is_a: FYPO:0002909 ! decreased protein localization to chromatin during vegetative growth is_a: FYPO:0004311 ! abnormal protein localization to CENP-A containing chromatin intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0061644 ! protein localization to CENP-A containing chromatin relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0061644 ! protein localization to CENP-A containing chromatin created_by: midori creation_date: 2015-01-19T11:49:39Z [Term] id: FYPO:0004314 name: normal protein localization to CENP-A containing chromatin def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the CENP-A containing chromatin is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to CENP-A containing chromatin" EXACT [PomBase:mah] synonym: "normal protein localization to CENP-A containing chromatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to CENP-A containing chromatin during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein localization to centromeric core region chromatin" EXACT [GO:0061638] is_a: FYPO:0001509 ! normal protein localization to chromatin is_a: FYPO:0002574 ! normal protein localization to centromere intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0061644 ! protein localization to CENP-A containing chromatin intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0061644 ! protein localization to CENP-A containing chromatin relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-01-19T11:51:16Z [Term] id: FYPO:0004315 name: abnormal microtubule cytoskeleton during vegetative growth def: "A physical cellular phenotype in which the amount, distribution, or morphology of all or part of the microtubule cytoskeleton is abnormal." [PomBase:mah] comment: Note that an abnormal microtubule cytoskeleton organization process may, but does not necessarily, result in a physically abnormal microtubule cytoskeleton. synonym: "abnormal microtubule cytoskeleton during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal microtubule cytoskeleton physical object quality during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth is_a: FYPO:0002399 ! abnormal microtubule cytoskeleton intersection_of: PATO:0001241 ! physical object quality intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0015630 ! microtubule cytoskeleton intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0015630 ! microtubule cytoskeleton relationship: output_of FYPO:0001350 ! abnormal microtubule cytoskeleton organization during vegetative growth relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-01-19T12:11:31Z [Term] id: FYPO:0004316 name: abnormal post-anaphase array def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the amount, distribution, or morphology of all or part of the post-anaphase array of microtubules is abnormal." [PomBase:mah] comment: Note that an abnormal post-anaphase microtubule array organization process may, but does not necessarily, result in abnormal post-anaphase microtubule array structure. synonym: "abnormal post-anaphase array during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal post-anaphase array physical object quality during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal post-anaphase microtubule array during vegetative growth" EXACT [GO:1990295] is_a: FYPO:0004315 ! abnormal microtubule cytoskeleton during vegetative growth intersection_of: PATO:0001241 ! physical object quality intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990295 ! post-anaphase microtubule array intersection_of: qualifier PATO:0000460 ! abnormal relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990295 ! post-anaphase microtubule array relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-01-19T12:17:46Z [Term] id: FYPO:0004317 name: abnormal post-anaphase array morphology def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, or structure of the post-anaphase array of microtubules is abnormal." [PomBase:mah] comment: Note that an abnormal post-anaphase microtubule array organization process may, but does not necessarily, result in abnormal post-anaphase microtubule array structure. synonym: "abnormal microtubule cytoskeleton morphology during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal post-anaphase array morphology during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal post-anaphase microtubule array morphology" EXACT [GO:1990295] is_a: FYPO:0001418 ! abnormal microtubule cytoskeleton morphology during vegetative growth is_a: FYPO:0004316 ! abnormal post-anaphase array intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990295 ! post-anaphase microtubule array intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990295 ! post-anaphase microtubule array relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-01-19T12:18:25Z [Term] id: FYPO:0004318 name: abolished mitotic cell cycle spindle assembly checkpoint def: "A cell cycle checkpoint phenotype in which cell cycle regulation mediated by the mitotic cell cycle spindle assembly checkpoint does not occur under conditions that normally trigger the checkpoint signaling and response. Normally, the mitotic spindle assembly checkpoint delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GO:0007094, PMID:11432827, PomBase:mah] is_a: FYPO:0000168 ! abnormal mitotic cell cycle spindle assembly checkpoint is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0007094 ! mitotic spindle assembly checkpoint relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0007094 ! mitotic spindle assembly checkpoint created_by: midori creation_date: 2015-01-19T12:30:47Z [Term] id: FYPO:0004319 name: increased cyclin-dependent protein kinase activity def: "A molecular function phenotype in which the observed rate of a cyclin-dependent protein kinase activity is increased." [PomBase:mah] is_a: FYPO:0002700 ! increased protein kinase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0097472 ! cyclin-dependent protein kinase activity relationship: inheres_in GO:0097472 ! cyclin-dependent protein kinase activity created_by: midori creation_date: 2015-01-21T11:46:31Z [Term] id: FYPO:0004320 name: altered DNA level def: "A cell phenotype in which the amount of DNA measured in a cell differs from normal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate synonym: "abnormal DNA content" EXACT [PomBase:mah] synonym: "abnormal DNA level" EXACT [PomBase:mah] synonym: "altered cellular DNA level" EXACT [PomBase:mah] is_a: FYPO:0000989 ! altered level of substance in cell intersection_of: PATO:0001159 ! concentrated intersection_of: inheres_in CL:0000000 ! cell intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:16991 ! deoxyribonucleic acid relationship: inheres_in CL:0000000 ! cell relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:16991 ! deoxyribonucleic acid created_by: midori creation_date: 2015-01-21T13:48:16Z [Term] id: FYPO:0004321 name: altered DNA level during vegetative growth def: "A cell phenotype in which the amount of DNA measured in a cell differs from normal when the cell is in the vegetative growth phase of the life cycle." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "abnormal DNA content during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal DNA level during vegetative growth" EXACT [PomBase:mah] synonym: "altered cellular DNA level during vegetative growth" EXACT [PomBase:mah] synonym: "altered DNA level during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001323 ! altered level of substance in cell during vegetative growth is_a: FYPO:0004320 ! altered DNA level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000460 ! abnormal intersection_of: towards CHEBI:16991 ! deoxyribonucleic acid relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000460 ! abnormal relationship: towards CHEBI:16991 ! deoxyribonucleic acid created_by: midori creation_date: 2015-01-21T13:48:25Z [Term] id: FYPO:0004322 name: decreased spatial extent of CENP-A containing nucleosome assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which nucleosomes containing the histone H3 variant CenH3 (also called CENP-A; Cnp1 in S. pombe) are assembled over a smaller portion of the chromosome than normal. CENP-A-containing nucleosomes are normally assembled into chromatin around centromeres, encompassing the central core and centromeric inner repeat regions." [GO:0034080, PMID:18493607, PomBase:mah, PomBase:vw] synonym: "decreased extent of CENP-A containing nucleosome" RELATED [PomBase:vw] synonym: "decreased spatial extent of CenH3-containing nucleosome assembly at centromere" RELATED [GO:0034080] synonym: "decreased spatial extent of CENP-A containing nucleosome assembly at centromere" EXACT [GO:0034080] synonym: "decreased spatial extent of CENP-A containing nucleosome assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased spatial extent of CENP-A containing nucleosome assembly during vegetative growth" EXACT [PomBase:mah] synonym: "decreased spatial extent of CENP-A deposition" RELATED [GO:0034080] synonym: "decreased spatial extent of CENP-A loading" RELATED [GO:0034080] synonym: "decreased spatial extent of centromere-specific histone exchange" EXACT [GO:0034080] synonym: "decreased spatial extent of centromere-specific nucleosome assembly" EXACT [GO:0034080] synonym: "decreased spatial extent of centromeric DNA replication-independent nucleosome assembly" EXACT [GO:0034080] synonym: "decreased spatial extent of DNA replication-independent nucleosome assembly at centromere" EXACT [GO:0034080] synonym: "reduced spatial extent of CENP-A containing nucleosome assembly" EXACT [PomBase:mah] is_a: FYPO:0003409 ! abnormal CENP-A containing nucleosome assembly created_by: midori creation_date: 2015-01-21T14:17:27Z [Term] id: FYPO:0004323 name: increased histone H4-K5, H4-K8, H4-K12 and H4-K16 acetylation at centromere central core def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which acetylation of lysine at positions 5, 8, 12 and 16 of histone H4 in at the centromere central core occurs to a greater extent than normal." [PMID:18493607, PomBase:mah] comment: Modifications detected by antibody (see http://www.millipore.com/coa.nsf/a73664f9f981af8c852569b9005b4eee/aa10134d44ac430a8525730600550ec4/$FILE/06-866-19336.pdf). synonym: "increased histone H4 acetylation (K5, K8, K12 and K16) at centromere central core" EXACT [PomBase:mah] synonym: "increased histone H4-K5, H4-K8, H4-K12 and H4-K16 acetylation at centromere central core during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H4-K5, H4-K8, H4-K12 and H4-K16 acetylation at centromere central core during vegetative growth" EXACT [PomBase:mah] synonym: "increased histone H4K5, H4K8, H4K12 and H4K16 acetylation at centromere central core" EXACT [PomBase:mah] is_a: FYPO:0000332 ! increased histone acetylation created_by: midori creation_date: 2015-01-21T14:19:15Z [Term] id: FYPO:0004324 name: increased histone H4-K16 acetylation at centromere central core def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which acetylation of lysine at position 16 of histone H4 in at the centromere central core occurs to a greater extent than normal." [PMID:18493607, PomBase:mah] synonym: "increased histone H4-K16 acetylation at centromere central core during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H4-K16 acetylation at centromere central core during vegetative growth" EXACT [PomBase:mah] synonym: "increased histone H4K16 acetylation at centromere central core" EXACT [PomBase:mah] is_a: FYPO:0002365 ! increased histone H4 acetylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0043984 ! histone H4-K16 acetylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0043984 ! histone H4-K16 acetylation created_by: midori creation_date: 2015-01-21T14:22:48Z [Term] id: FYPO:0004325 name: sensitive to 5-fluorouracil def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to 5-fluorouracil. Cells stop growing (and may die) at a concentration of 5-fluorouracil that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to 5-fluorouracil" EXACT [PomBase:mah] synonym: "sensitive to 5-fluorouracil during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to 5-fluorouracil during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:46345 ! 5-fluorouracil relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:46345 ! 5-fluorouracil created_by: midori creation_date: 2015-01-21T14:40:59Z [Term] id: FYPO:0004326 name: increased duration of protein phosphorylation during cellular response to methylglyoxal def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the duration of protein phosphorylation is increased during a cellular response to methylglyoxal. All phosphorylation may be affected, or only phosphorylation of specific proteins, or even specific sites within specific proteins." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased duration of protein phosphorylation during cellular response to methylglyoxal during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased duration of protein phosphorylation during cellular response to methylglyoxal during vegetative growth" EXACT [PomBase:mah] synonym: "prolonged protein phosphorylation during cellular response to methylglyoxal" EXACT [PomBase:mah] is_a: FYPO:0000548 ! increased duration of protein modification intersection_of: PATO:0000498 ! increased duration intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: happens_during GO:0097238 ! cellular response to methylglyoxal intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: happens_during GO:0097238 ! cellular response to methylglyoxal relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2015-01-21T14:43:13Z [Term] id: FYPO:0004327 name: normal protein phosphorylation during cellular response to sorbitol def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins is normal (i.e. indistinguishable from wild type) during a cellular response to sorbitol." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein phosphorylation during cellular response to sorbitol during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein phosphorylation during cellular response to sorbitol during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000776 ! normal protein phosphorylation during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: happens_during GO:0072709 ! cellular response to sorbitol intersection_of: inheres_in GO:0006468 ! protein phosphorylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: happens_during GO:0072709 ! cellular response to sorbitol relationship: inheres_in GO:0006468 ! protein phosphorylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-01-21T14:44:18Z [Term] id: FYPO:0004328 name: normal protein localization during mitosis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which cellular protein localization is normal (i.e. indistinguishable from wild type) during mitosis." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal cellular protein localization during mitosis" EXACT [PomBase:mah] synonym: "normal protein localisation during mitosis during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein localization during mitotic M phase" EXACT [PomBase:mah] synonym: "normal protein localization during mitotic nuclear division" EXACT [GO:0007067] is_a: FYPO:0000644 ! normal protein localization during vegetative growth is_a: FYPO:0001071 ! normal transport intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0007067 ! mitotic nuclear division intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034613 ! cellular protein localization intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0007067 ! mitotic nuclear division relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034613 ! cellular protein localization relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-01-29T11:18:47Z [Term] id: FYPO:0004329 name: normal mitotic rDNA separation def: "A cellular process phenotype in which mitotic sister chromatid separation is normal (i.e. indistinguishable from wild type) in regions containing ribosomal DNA (rDNA). Mitotic sister chromatid separation is the process in which sister chromatids are physically detached from each other during mitosis." [GO:0051306, PMID:17032733, PomBase:mah] synonym: "normal mitotic chromosome separation at rDNA" EXACT [PomBase:mah] synonym: "normal mitotic rDNA separation during vegetative growth" EXACT [PomBase:mah] synonym: "normal mitotic ribosomal DNA separation" EXACT [PomBase:mah] synonym: "normal mitotic sister chromatid separation at rDNA" EXACT [GO:0051306] is_a: FYPO:0004301 ! normal mitotic sister chromatid separation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051306 ! mitotic sister chromatid separation intersection_of: occurs_at SO:0001637 ! rRNA_gene intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051306 ! mitotic sister chromatid separation relationship: occurs_at SO:0001637 ! rRNA_gene relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-01-29T11:23:10Z [Term] id: FYPO:0004330 name: normal mitotic telomere separation def: "A cellular process phenotype in which mitotic sister chromatid separation is normal (i.e. indistinguishable from wild type) at telomeres. Mitotic sister chromatid separation is the process in which sister chromatids are physically detached from each other during mitosis." [GO:0051306, PMID:17032733, PomBase:mah] synonym: "normal mitotic chromosome separation at telomere" EXACT [PomBase:mah] synonym: "normal mitotic sister chromatid separation at telomere" EXACT [GO:0051306] synonym: "normal mitotic telomere separation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0004301 ! normal mitotic sister chromatid separation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051306 ! mitotic sister chromatid separation intersection_of: occurs_at GO:0000781 ! chromosome, telomeric region intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051306 ! mitotic sister chromatid separation relationship: occurs_at GO:0000781 ! chromosome, telomeric region relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-01-29T11:25:47Z [Term] id: FYPO:0004331 name: normal chromatin silencing at centromere central core def: "A transcription regulation phenotype observed in the vegetative growth phase of the life cycle in which chromatin silencing at the central core of the centromeric regions is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: Note that the centromere central core corresponds to SO:0001796. synonym: "normal centromere central core chromatin silencing" EXACT [PomBase:mah] synonym: "normal chromatin silencing at centromere central core during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal chromatin silencing at centromere central core during vegetative growth" EXACT [PomBase:mah] synonym: "normal chromatin silencing at centromeric central core" EXACT [PomBase:mah] is_a: FYPO:0002360 ! normal chromatin silencing at centromere intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072692 ! chromatin silencing at centromere central core intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072692 ! chromatin silencing at centromere central core relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-01-29T11:31:51Z [Term] id: FYPO:0004332 name: delayed protein degradation during mitosis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which protein degradation begins later than normal during mitosis." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "delayed protein breakdown during mitosis" EXACT [GO:0030163] synonym: "delayed protein catabolic process during mitosis" EXACT [GO:0030163] synonym: "delayed protein catabolism during mitosis" EXACT [GO:0030163, PomBase:mah] synonym: "delayed protein degradation during mitosis" EXACT [GO:0030163, PomBase:mah] synonym: "delayed protein degradation during mitotic M phase" EXACT [PomBase:mah] synonym: "delayed protein degradation during mitotic nuclear division" EXACT [GO:0007067] is_a: FYPO:0000845 ! abnormal protein degradation during vegetative growth is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0007067 ! mitotic nuclear division intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071596 ! ubiquitin-dependent protein catabolic process via the N-end rule pathway relationship: happens_during GO:0007067 ! mitotic nuclear division relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071596 ! ubiquitin-dependent protein catabolic process via the N-end rule pathway created_by: midori creation_date: 2015-01-29T12:03:37Z [Term] id: FYPO:0004333 name: increased protein phosphorylation during cellular response to hydrogen peroxide def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a greater extent than normal during a cellular response to hydrogen peroxide." [PMID:22139357, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein phosphorylation during cellular response to H2O2" EXACT [PomBase:mah] synonym: "increased protein phosphorylation during cellular response to hydrogen peroxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein phosphorylation during cellular response to hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003692 ! increased protein phosphorylation during cellular response to oxidative stress intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0070301 ! cellular response to hydrogen peroxide intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0070301 ! cellular response to hydrogen peroxide relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2015-01-29T13:34:48Z [Term] id: FYPO:0004334 name: increased protein localization to nucleus during cellular response to hydrogen peroxide def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleus is increased during a cellular response to hydrogen peroxide." [PMID:22139357, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to nucleus during cellular response to hydrogen peroxide" EXACT [GO:0034504, PomBase:mah] synonym: "increased protein localization to nucleus during cellular response to H2O2" EXACT [PomBase:mah] synonym: "increased protein localization to nucleus during cellular response to hydrogen peroxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein localization to nucleus during cellular response to hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001130 ! increased protein localization to nucleus during vegetative growth intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0070301 ! cellular response to hydrogen peroxide intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034504 ! protein localization to nucleus relationship: happens_during GO:0070301 ! cellular response to hydrogen peroxide relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034504 ! protein localization to nucleus created_by: midori creation_date: 2015-01-29T13:39:28Z [Term] id: FYPO:0004335 name: abolished protein binding during cellular response to hydrogen peroxide def: "A molecular function phenotype in which the binding of one protein to another does not occur during a cellular response to hydrogen peroxide. The relevant proteins may include the one encoded by the mutated gene, or may both be encoded by different genes." [PMID:22139357, PomBase:mah] comment: This term can be used for any protein-protein interaction that is affected by a mutation, whether or not the mutated gene product is one of the interacting proteins. We recommend noting which proteins were used in the assay when annotating to this term. synonym: "abolished protein binding during cellular response to H2O2" EXACT [PomBase:mah] synonym: "abolished protein-protein interaction during cellular response to hydrogen peroxide" EXACT [PomBase:mah] synonym: "protein binding abolished during cellular response to hydrogen peroxide" EXACT [PomBase:mah] is_a: FYPO:0003425 ! abolished protein binding during cellular response to rapamycin intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0070301 ! cellular response to hydrogen peroxide intersection_of: during GO:0072752 ! cellular response to rapamycin intersection_of: towards GO:0005515 ! protein binding relationship: during GO:0070301 ! cellular response to hydrogen peroxide relationship: during GO:0072752 ! cellular response to rapamycin relationship: towards GO:0005515 ! protein binding created_by: midori creation_date: 2015-01-29T13:42:03Z [Term] id: FYPO:0004336 name: abnormal protein localization to mitochondrion def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the mitochondrion is abnormal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to mitochondrion" EXACT [PomBase:mah] synonym: "abnormal protein localization to mitochondria" EXACT [PomBase:mah] synonym: "abnormal protein localization to mitochondrion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein localization to mitochondrion during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000443 ! abnormal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0070585 ! protein localization to mitochondrion intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0070585 ! protein localization to mitochondrion relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-01-29T13:59:03Z [Term] id: FYPO:0004337 name: abolished protein localization to mitochondrion def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the mitochondrion does not occur." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to mitochondrion" EXACT [PomBase:mah] synonym: "abolished protein localization to mitochondrion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein absent from mitochondrion" RELATED [PomBase:mah] synonym: "protein localization to mitochondrion abolished" EXACT [PomBase:mah] synonym: "protein localization to mitochondrion abolished during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001179 ! protein localization abolished during vegetative growth is_a: FYPO:0004336 ! abnormal protein localization to mitochondrion intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0070585 ! protein localization to mitochondrion relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0070585 ! protein localization to mitochondrion created_by: midori creation_date: 2015-01-29T14:05:52Z [Term] id: FYPO:0004338 name: abolished cell population growth on ethanol carbon source def: "A vegetative cell population growth phenotype in which a cell population does not grow in a medium containing ethanol as the carbon source." [PMID:22139357, PomBase:mah] comment: Use this term for a population of cells that does not grow with ethanol as the carbon source, but does grow using a different carbon source (a cell population that does not grow on any media would be considered inviable). Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "abolished ethanol utilization" RELATED [PomBase:mah, PomBase:vw] synonym: "abolished growth on ethanol carbon source" BROAD [PomBase:mah] synonym: "abolished vegetative cell population growth on ethanol carbon source" EXACT [PomBase:mah] synonym: "cell population growth on ethanol carbon source abolished" EXACT [PomBase:mah] is_a: FYPO:0001575 ! abolished vegetative cell population growth intersection_of: FYPO:0001575 ! abolished vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:16236 ! ethanol relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:16236 ! ethanol created_by: midori creation_date: 2015-01-29T14:07:32Z [Term] id: FYPO:0004339 name: decreased protein localization to nucleus during cellular response to hydrogen peroxide def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleus is decreased during a cellular response to hydrogen peroxide." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to nucleus during cellular response to hydrogen peroxide" EXACT [GO:0034504, PomBase:mah] synonym: "decreased protein localization to nucleus during cellular response to H2O2" EXACT [PomBase:mah] synonym: "decreased protein localization to nucleus during cellular response to hydrogen peroxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to nucleus during cellular response to hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to nucleus during cellular response to hydrogen peroxide" EXACT [PomBase:mah] is_a: FYPO:0001514 ! decreased protein localization to nucleus during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0070301 ! cellular response to hydrogen peroxide intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034504 ! protein localization to nucleus relationship: happens_during GO:0070301 ! cellular response to hydrogen peroxide relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034504 ! protein localization to nucleus created_by: midori creation_date: 2015-01-29T14:09:16Z [Term] id: FYPO:0004340 name: abnormal mitochondrial fission def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitochondrial fission, the division of a mitochondrion into two or more separate compartments, is abnormal." [GO:0000266, PomBase:mah] synonym: "abnormal mitochondrial division" EXACT [GO:0000266, PomBase:mah] synonym: "abnormal mitochondrial fission during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal mitochondrial fission during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal mitochondrial proliferation" RELATED [GO:0000266, PomBase:mah] is_a: FYPO:0000809 ! abnormal mitochondrion organization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000266 ! mitochondrial fission intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000266 ! mitochondrial fission relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-01-29T14:11:28Z [Term] id: FYPO:0004341 name: delayed mitochondrial fission during cellular response to hydrogen peroxide def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitochondrial fission, the division of a mitochondrion into two or more separate compartments, begins later than normal during a cellular response to hydrogen peroxide." [PMID:22139357, PomBase:mah] synonym: "delayed mitochondrial division" EXACT [GO:0000266, PomBase:mah] synonym: "delayed mitochondrial fission during cellular response to H2O2" EXACT [PomBase:mah] synonym: "delayed mitochondrial fission during cellular response to hydrogen peroxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "delayed mitochondrial fission during cellular response to hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] synonym: "delayed mitochondrial fission during mitotic cell cycle" RELATED [PomBase:mah] synonym: "delayed mitochondrial fission during vegetative growth" EXACT [PomBase:mah] synonym: "delayed mitochondrial proliferation" RELATED [GO:0000266, PomBase:mah] is_a: FYPO:0004340 ! abnormal mitochondrial fission is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0070301 ! cellular response to hydrogen peroxide intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000266 ! mitochondrial fission relationship: happens_during GO:0070301 ! cellular response to hydrogen peroxide relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000266 ! mitochondrial fission created_by: midori creation_date: 2015-01-29T14:13:00Z [Term] id: FYPO:0004342 name: increased LTR-derived RNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of any RNA transcribed from long terminal repeat elements (LTRs) measured in a cell is higher than normal." [PMID:24095277, PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased accumulation of LTR-derived RNAs" RELATED [PomBase:vw] synonym: "increased long terminal repeat-derived RNA level" EXACT [PomBase:mah] synonym: "increased LTR-derived RNA accumulation" RELATED [PomBase:mah] synonym: "increased LTR-derived RNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased LTR-derived RNA level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003558 ! increased repeat element RNA level created_by: midori creation_date: 2015-01-29T14:47:36Z [Term] id: FYPO:0004343 name: increased wtf-derived RNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of any RNA transcribed from wtf elements measured in a cell is higher than normal." [PMID:24095277, PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased accumulation of wtf-derived RNAs" RELATED [PomBase:vw] synonym: "increased wtf element-derived RNA level" EXACT [PomBase:mah] synonym: "increased wtf-derived RNA accumulation" RELATED [PomBase:mah] synonym: "increased wtf-derived RNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased wtf-derived RNA level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003558 ! increased repeat element RNA level created_by: midori creation_date: 2015-01-29T14:50:29Z [Term] id: FYPO:0004344 name: increased viability upon nitrogen starvation def: "A cell population phenotype in which a larger than normal proportion of the population remains viable when cells the population are subject to nitrogen starvation." [PomBase:mah] synonym: " increased viability during nitrogen starvation" EXACT [PomBase:al] synonym: "increased cell population viability upon nitrogen starvation" EXACT [PomBase:mah] synonym: "increased viability upon nitrogen depletion" EXACT [PomBase:al] synonym: "increased viability upon nitrogen deprivation" EXACT [PomBase:mah] is_a: FYPO:0002057 ! cell population viability created_by: midori creation_date: 2015-01-29T14:54:06Z [Term] id: FYPO:0004345 name: decreased protein localization to chromatin at LTRs def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to chromatin at long terminal repeats is decreased." [PMID:25002536, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to chromatin at LTRs" EXACT [PomBase:mah] synonym: "decreased protein localization to chromatin at long terminal repeats" EXACT [PomBase:mah] synonym: "decreased protein localization to chromatin at LTRs during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to chromatin at LTRs during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to chromatin at LTRs" EXACT [PomBase:mah] is_a: FYPO:0002909 ! decreased protein localization to chromatin during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071168 ! protein localization to chromatin intersection_of: occurs_at SO:0000286 ! long_terminal_repeat relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071168 ! protein localization to chromatin relationship: occurs_at SO:0000286 ! long_terminal_repeat created_by: midori creation_date: 2015-01-29T14:58:45Z [Term] id: FYPO:0004346 name: decreased protein localization to chromatin at ncRNA genes def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to chromatin at non-coding RNA genes is decreased." [PMID:25002536, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to chromatin at ncRNA genes" EXACT [PomBase:mah] synonym: "decreased protein localization to chromatin at ncRNA genes during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to chromatin at ncRNA genes during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein localization to chromatin at non-coding RNA genes" EXACT [PomBase:mah] synonym: "reduced protein localization to chromatin at ncRNA genes" EXACT [PomBase:mah] is_a: FYPO:0002909 ! decreased protein localization to chromatin during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071168 ! protein localization to chromatin intersection_of: occurs_at SO:0001263 ! ncRNA_gene relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071168 ! protein localization to chromatin relationship: occurs_at SO:0001263 ! ncRNA_gene created_by: midori creation_date: 2015-01-29T15:00:04Z [Term] id: FYPO:0004347 name: increased histone H3-K9 acetylation at protein coding gene def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which acetylation of lysine at position 9 of histone H3 occurs to a greater extent than normal in regions containing protein-coding genes." [PomBase:mah] synonym: "increased histone H3-K9 acetylation at protein coding gene during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H3-K9 acetylation at protein coding gene during vegetative growth" EXACT [PomBase:mah] synonym: "increased histone H3-K9 acetylation at protein-coding gene" EXACT [PomBase:mah] synonym: "increased histone H3K9 acetylation at protein coding gene" EXACT [GO:0043970, PomBase:mah] is_a: FYPO:0000892 ! increased histone H3-K9 acetylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0043970 ! histone H3-K9 acetylation intersection_of: occurs_at SO:0001217 ! protein_coding_gene relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0043970 ! histone H3-K9 acetylation relationship: occurs_at SO:0001217 ! protein_coding_gene created_by: midori creation_date: 2015-01-29T15:02:24Z [Term] id: FYPO:0004348 name: normal growth on methylglyoxal def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing methylglyoxal." [PomBase:mah] synonym: "normal cell population growth in presence of methylglyoxal" EXACT [PomBase:mah] synonym: "normal cell population growth on methylglyoxal" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to methylglyoxal" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on methylglyoxal" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:17158 ! methylglyoxal relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:17158 ! methylglyoxal created_by: midori creation_date: 2015-01-29T15:17:53Z [Term] id: FYPO:0004349 name: decreased RNA level during cellular response to methylglyoxal def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to methylglyoxal is lower than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased RNA accumulation during cellular response to methylglyoxal" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to methylglyoxal during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to methylglyoxal during vegetative growth" EXACT [PomBase:mah] synonym: "decreased transcript level during cellular response to methylglyoxal" EXACT [PomBase:vw] synonym: "reduced RNA level during cellular response to methylglyoxal" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: exists_during GO:0097238 ! cellular response to methylglyoxal intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: exists_during GO:0097238 ! cellular response to methylglyoxal relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2015-01-29T15:20:59Z [Term] id: FYPO:0004350 name: normal RNA level during cellular response to methylglyoxal def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to methylglyoxal is normal (i.e. indistinguishable from wild type). Total RNA or a specific RNA, such as the mRNA transcribed from a gene of interest, may be affected." [PomBase:mah] comment: We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "normal mRNA level during cellular response to methylglyoxal" NARROW [PomBase:mah] synonym: "normal RNA accumulation during cellular response to methylglyoxal" RELATED [PomBase:mah] synonym: "normal RNA level during cellular response to methylglyoxal during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal RNA level during cellular response to methylglyoxal during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001317 ! normal RNA level during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: exists_during GO:0097238 ! cellular response to methylglyoxal intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: exists_during GO:0097238 ! cellular response to methylglyoxal relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2015-01-29T15:23:34Z [Term] id: FYPO:0004351 name: increased protein localization to nucleus during cellular response to methylglyoxal def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleus is increased during a cellular response to methylglyoxal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to nucleus during cellular response to methylglyoxal" EXACT [GO:0034504, PomBase:mah] synonym: "increased protein localization to nucleus during cellular response to methylglyoxal during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein localization to nucleus during cellular response to methylglyoxal during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001130 ! increased protein localization to nucleus during vegetative growth intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: happens_during GO:0097238 ! cellular response to methylglyoxal intersection_of: inheres_in GO:0034504 ! protein localization to nucleus relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: happens_during GO:0097238 ! cellular response to methylglyoxal relationship: inheres_in GO:0034504 ! protein localization to nucleus created_by: midori creation_date: 2015-01-29T15:24:30Z [Term] id: FYPO:0004352 name: decreased protein localization to nucleus during cellular response to methylglyoxal def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleus is decreased during a cellular response to methylglyoxal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to nucleus during cellular response to methylglyoxal" EXACT [PomBase:mah] synonym: "decreased protein localization to nucleus during cellular response to methylglyoxal during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to nucleus during cellular response to methylglyoxal during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to nucleus during cellular response to methylglyoxal" EXACT [PomBase:mah] is_a: FYPO:0001514 ! decreased protein localization to nucleus during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: happens_during GO:0097238 ! cellular response to methylglyoxal intersection_of: inheres_in GO:0034504 ! protein localization to nucleus relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: happens_during GO:0097238 ! cellular response to methylglyoxal relationship: inheres_in GO:0034504 ! protein localization to nucleus created_by: midori creation_date: 2015-01-29T15:25:11Z [Term] id: FYPO:0004353 name: increased protein phosphorylation during mitotic S phase def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a greater extent than normal during S phase of the mitotic cell cycle." [PomBase:mah] synonym: "increased protein phosphorylation during mitotic S phase during vegetative growth" EXACT [PomBase:mah] synonym: "increased protein phosphorylation during mitotic S-phase" EXACT [PomBase:vw] synonym: "increased protein/peptide phosphorylation during mitotic S phase" EXACT [PomBase:mah] is_a: FYPO:0001038 ! increased protein phosphorylation during vegetative growth intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0000084 ! mitotic S phase intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0000084 ! mitotic S phase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2015-01-29T15:32:00Z [Term] id: FYPO:0004354 name: increased protein phosphorylation during mitotic G1 phase def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a greater extent than normal during G1 phase of the mitotic cell cycle." [PomBase:mah] synonym: "increased protein phosphorylation during mitotic G1 phase during vegetative growth" EXACT [PomBase:mah] synonym: "increased protein phosphorylation during mitotic G1-phase" EXACT [PomBase:vw] synonym: "increased protein/peptide phosphorylation during mitotic G1 phase" EXACT [PomBase:mah] is_a: FYPO:0001038 ! increased protein phosphorylation during vegetative growth intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0000080 ! mitotic G1 phase intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0000080 ! mitotic G1 phase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2015-01-29T15:32:39Z [Term] id: FYPO:0004355 name: increased protein phosphorylation during mitosis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a greater extent than normal during mitosis." [PomBase:mah] synonym: "increased protein phosphorylation during mitosis during vegetative growth" EXACT [PomBase:mah] synonym: "increased protein phosphorylation during mitotic M phase" EXACT [PomBase:mah] synonym: "increased protein phosphorylation during mitotic nuclear division" EXACT [GO:0007067] synonym: "increased protein/peptide phosphorylation during mitosis" EXACT [PomBase:mah] is_a: FYPO:0001038 ! increased protein phosphorylation during vegetative growth intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0007067 ! mitotic nuclear division intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0007067 ! mitotic nuclear division relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2015-01-29T15:33:18Z [Term] id: FYPO:0004356 name: increased protein localization to nucleolus def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleolus is increased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to nucleolus" EXACT [PomBase:mah] synonym: "increased protein localization to nucleolus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein localization to nucleolus during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001130 ! increased protein localization to nucleus during vegetative growth is_a: FYPO:0003687 ! abnormal protein localization to nucleolus intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902570 ! protein localization to nucleolus relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902570 ! protein localization to nucleolus created_by: midori creation_date: 2015-01-29T15:36:57Z [Term] id: FYPO:0004357 name: decreased protein phosphorylation during mitosis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal during mitosis." [PomBase:mah] synonym: "decreased protein phosphorylation during mitosis during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein phosphorylation during mitotic M phase" EXACT [PomBase:mah] synonym: "decreased protein phosphorylation during mitotic nuclear division" EXACT [GO:0007067] synonym: "decreased protein/peptide phosphorylation during mitosis" EXACT [PomBase:mah] synonym: "reduced protein phosphorylation during mitosis" EXACT [PomBase:mah] is_a: FYPO:0002832 ! decreased protein phosphorylation during mitotic M phase intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0007067 ! mitotic nuclear division intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0007067 ! mitotic nuclear division relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2015-01-29T15:40:46Z [Term] id: FYPO:0004358 name: increased protein phosphatase activity during mitosis def: "A molecular function phenotype in which the observed rate of a protein phosphatase activity is increased during mitosis." [PomBase:mah] synonym: "increased phosphoprotein phosphatase activity during mitosis" EXACT [GO:0004721, PomBase:mah] synonym: "increased protein phosphatase activity during mitotic M phase" EXACT [PomBase:mah] synonym: "increased protein phosphatase activity during mitotic nuclear division" EXACT [GO:0007067] is_a: FYPO:0001758 ! increased protein phosphatase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0007067 ! mitotic nuclear division intersection_of: inheres_in GO:0004721 ! phosphoprotein phosphatase activity relationship: happens_during GO:0007067 ! mitotic nuclear division relationship: inheres_in GO:0004721 ! phosphoprotein phosphatase activity created_by: midori creation_date: 2015-01-29T15:43:00Z [Term] id: FYPO:0004359 name: abolished mitotic cell cycle DNA replication checkpoint def: "A cell cycle checkpoint phenotype in which cell cycle regulation mediated by the mitotic cell cycle DNA replication checkpoint does not occur under conditions that normally trigger the checkpoint signaling and response. The DNA replication checkpoint normally prevents the initiation of mitosis until DNA replication is complete." [GO:0033314, PMID:11988741, PomBase:mah] is_a: FYPO:0000173 ! abnormal mitotic cell cycle DNA replication checkpoint is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0033314 ! mitotic DNA replication checkpoint relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0033314 ! mitotic DNA replication checkpoint created_by: midori creation_date: 2015-01-29T15:48:14Z [Term] id: FYPO:0004360 name: decreased duration of mitotic cell cycle DNA replication checkpoint def: "A cell cycle checkpoint phenotype in which the duration of mitotic cell cycle arrest or delay due to regulation by the DNA replication checkpoint is shorter than normal. The DNA replication checkpoint normally prevents the initiation of mitosis until DNA replication is complete." [PomBase:mah] synonym: "decreased duration of DNA replication checkpoint" BROAD [PomBase:mah] synonym: "decreased duration of mitotic cell cycle DNA replication checkpoint activation" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "reduced duration of mitotic cell cycle DNA replication checkpoint" EXACT [PomBase:mah] is_a: FYPO:0000173 ! abnormal mitotic cell cycle DNA replication checkpoint is_a: PATO:0000499 ! decreased duration intersection_of: PATO:0000499 ! decreased duration intersection_of: inheres_in GO:0033314 ! mitotic DNA replication checkpoint relationship: inheres_in GO:0033314 ! mitotic DNA replication checkpoint created_by: midori creation_date: 2015-01-29T15:49:40Z [Term] id: FYPO:0004361 name: meiosis and sporulation in haploid during nitrogen starvation def: "A cellular process phenotype in which haploid cells undergo meiotic division and attempt to sporulate when the cells are subject to nitrogen starvation. Haploid meiosis often results in the formation of a structure that resembles an azygotic ascus. Spores produced from a haploid cell have poor viability and appear to contain only 1/2C DNA on average." [DOI:10.1007/BF00332932, PomBase:mah] synonym: "haploid meiosis during nitrogen starvation" RELATED [PomBase:al] synonym: "haploid sporulation during nitrogen starvation" RELATED [PomBase:al] synonym: "increased haploid meiosis during nitrogen starvation" RELATED [PomBase:mah] synonym: "meiosis in haploid during nitrogen starvation" RELATED [PomBase:mah] synonym: "sporulation in haploid during nitrogen starvation" RELATED [PomBase:mah] is_a: FYPO:0001886 ! meiosis and sporulation in haploid created_by: midori creation_date: 2015-01-29T15:56:24Z [Term] id: FYPO:0004362 name: increased protein localization to old growing cell tip def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to an old growing cell tip is increased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to old growing cell tip" EXACT [GO:0035840, PomBase:mah] synonym: "increased protein localization to old growing cell end" EXACT [PomBase:mah] synonym: "increased protein localization to old growing cell tip during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein localization to old growing cell tip during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002852 ! increased protein localization to cell tip intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903858 ! protein localization to old growing cell tip relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903858 ! protein localization to old growing cell tip created_by: midori creation_date: 2015-02-02T16:15:35Z [Term] id: FYPO:0004363 name: altered level of stress responsive gene mRNA during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more messenger RNAs that are normally expressed during a cellular response to stress measured in a cell differs from normal (i.e. is higher or lower than observed in wild-type cells during vegetative growth)." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "abnormal level of stress responsive gene mRNA during vegetative growth" EXACT [PomBase:mah] synonym: "altered level of cellular response to stress responsive gene mRNA" EXACT [PomBase:al] synonym: "altered level of stress responsive gene mRNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "altered level of stress responsive gene transcripts during vegetative growth" EXACT [PomBase:vw] synonym: "altered mRNA level of stress responsive genes during vegetative growth" EXACT [PomBase:al] synonym: "altered stress responsive gene mRNA accumulation during vegetative growth" RELATED [PomBase:mah] is_a: FYPO:0002934 ! altered mRNA level during vegetative growth created_by: midori creation_date: 2015-02-10T12:15:37Z [Term] id: FYPO:0004364 name: abnormal dioxygenase activity def: "A molecular function phenotype in which the observed rate of a dioxygenase activity is abnormal." [PomBase:mah] is_a: FYPO:0000689 ! abnormal oxidoreductase activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0051213 ! dioxygenase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0051213 ! dioxygenase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-02-10T12:26:02Z [Term] id: FYPO:0004365 name: abolished dioxygenase activity def: "A molecular function phenotype in which a dioxygenase activity is absent." [PomBase:mah] synonym: "dioxygenase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0004364 ! abnormal dioxygenase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0051213 ! dioxygenase activity relationship: towards GO:0051213 ! dioxygenase activity created_by: midori creation_date: 2015-02-10T12:26:07Z [Term] id: FYPO:0004366 name: syntelic kinetochore attachment during mitosis def: "A cellular process phenotype in which the attachment of spindle microtubules to the kinetochore during a mitotic nuclear division results in the connection of both sister kinetochores to microtubules from the same spindle pole." [PMID:17426725] comment: Syntelic attachment activates the spindle assembly checkpoint, presumably due to lack of tension between the sister chromatids. If uncorrected, syntelic attachment will result in segregation of both sister chromatids to the same daughter cell, generating aneuploidy. synonym: "syntelic attachment of spindle microtubules to kinetochore during mitosis" EXACT [PomBase:mah] synonym: "syntelic kinetochore attachment during mitotic M phase" EXACT [PomBase:mah] synonym: "syntelic kinetochore attachment during mitotic nuclear division" EXACT [GO:0007067] synonym: "syntelic kinetochore attachment during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0004213 ! abnormal attachment of mitotic spindle microtubules to kinetochore created_by: midori creation_date: 2015-02-10T12:37:25Z [Term] id: FYPO:0004367 name: normal mitotic spindle assembly def: "A cellular process phenotype in which assembly of the mitotic spindle is normal (i.e. indistinguishable from wild type). Spindle assembly is the aggregation, arrangement and bonding together of a set of components to form the spindle." [PomBase:mah] synonym: "normal mitotic spindle assembly during vegetative growth" EXACT [PomBase:mah] synonym: "normal spindle assembly during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000899 ! normal microtubule cytoskeleton organization is_a: FYPO:0002741 ! normal mitotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0090307 ! mitotic spindle assembly intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_output FYPO:0001399 ! normal mitotic spindle relationship: inheres_in GO:0090307 ! mitotic spindle assembly relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-02-10T13:22:16Z [Term] id: FYPO:0004368 name: normal growth on arsenic def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing an arsenic-containing substance." [PomBase:mah] synonym: "normal cell population growth in presence of arsenic" EXACT [PomBase:mah] synonym: "normal cell population growth on arsenic" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to arsenic" RELATED [PomBase:al, PomBase:mah] synonym: "normal growth on arsenic molecular entity" EXACT [CHEBI:22632] synonym: "normal growth on arsenic-containing substance" EXACT [PomBase:mah] synonym: "normal vegetative cell population growth on arsenic" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:22632 ! arsenic molecular entity relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:22632 ! arsenic molecular entity created_by: midori creation_date: 2015-02-10T13:48:12Z [Term] id: FYPO:0004369 name: decreased vacuolar phytochelatin level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of phytochelatin measured in the vacuole is lower than normal." [PomBase:mah] synonym: "decreased level of phytochelatin in vacuole" EXACT [PomBase:mah] synonym: "decreased vacuolar phytochelatin level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased vacuolar phytochelatin level during vegetative growth" EXACT [PomBase:mah] synonym: "reduced level of phytochelatin in vacuole" EXACT [PomBase:mah] synonym: "reduced vacuolar phytochelatin level" EXACT [PomBase:mah] is_a: FYPO:0001602 ! decreased level of substance in vacuole is_a: FYPO:0002829 ! decreased cellular phytochelatin level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: towards CHEBI:60836 ! phytochelatin relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: towards CHEBI:60836 ! phytochelatin created_by: midori creation_date: 2015-02-10T13:57:23Z [Term] id: FYPO:0004370 name: decreased cadmium ion import into vacuole def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the import of cadmium ions into the vacuole occurs to a lower extent than normal." [GO:0036249, PomBase:mah] synonym: "decreased cadmium import into vacuole" EXACT [PomBase:al] synonym: "decreased cadmium ion import into vacuole during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cadmium ion import into vacuole during vegetative growth" EXACT [PomBase:mah] synonym: "reduced cadmium ion import into vacuole" EXACT [PomBase:mah] is_a: FYPO:0000598 ! decreased vacuolar transport intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0036249 ! cadmium ion import into vacuole relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0036249 ! cadmium ion import into vacuole created_by: midori creation_date: 2015-02-10T14:05:17Z [Term] id: FYPO:0004371 name: decreased duration of S-phase DNA damage checkpoint def: "A cell cycle checkpoint phenotype in which the duration of cell cycle arrest or delay due to regulation by the S-phase DNA damage checkpoint is lower than in wild type." [PomBase:mah] synonym: "decreased duration of intra-S DNA damage checkpoint" EXACT [PomBase:mah] synonym: "decreased duration of S-phase DNA damage checkpoint activation" RELATED [PomBase:mah] synonym: "decreased duration of S-phase DNA damage checkpoint during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased duration of S-phase DNA damage checkpoint during vegetative growth" EXACT [PomBase:mah] synonym: "premature S-phase DNA damage checkpoint deactivation" RELATED [PomBase:mah] synonym: "reduced duration of S-phase DNA damage checkpoint" EXACT [PomBase:mah] is_a: FYPO:0000006 ! abnormal DNA damage checkpoint is_a: PATO:0000499 ! decreased duration intersection_of: PATO:0000499 ! decreased duration intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0031573 ! intra-S DNA damage checkpoint relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0031573 ! intra-S DNA damage checkpoint created_by: midori creation_date: 2015-02-10T14:07:50Z [Term] id: FYPO:0004372 name: decreased response to mitotic G2 DNA damage checkpoint signaling def: "A cellular process phenotype in which a mitotic cell cycle arrest that normally occurs in response to the mitotic G2 DNA damage checkpoint is decreased. The mitotic G2 DNA damage checkpoint negatively regulates progression through the G2/M transition of the mitotic cell cycle in response to DNA damage. In a mutant, the checkpoint may fail to arrest or delay cell cycle progression under appropriate conditions, or the incidence or duration of arrest or delay may differ from wild type under any specified set of conditions." [GO:0072435, PomBase:mah] synonym: "decreased G2 DNA damage checkpoint during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased mitotic G2 DNA damage checkpoint during vegetative growth" EXACT [PomBase:mah] synonym: "reduced response to mitotic G2 DNA damage checkpoint signaling" EXACT [PomBase:mah] is_a: FYPO:0004373 ! abnormal mitotic G2 DNA damage checkpoint is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072435 ! response to mitotic G2 DNA damage checkpoint signaling relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072435 ! response to mitotic G2 DNA damage checkpoint signaling created_by: midori creation_date: 2015-02-10T14:20:52Z [Term] id: FYPO:0004373 name: abnormal mitotic G2 DNA damage checkpoint def: "A cell cycle checkpoint phenotype in which the mitotic G2 DNA damage checkpoint is abnormal. The mitotic G2 DNA damage checkpoint negatively regulates progression through the G2/M transition of the mitotic cell cycle in response to DNA damage. In a mutant, the checkpoint may fail to arrest or delay cell cycle progression under appropriate conditions, or the incidence or duration of arrest or delay may differ from wild type under any specified set of conditions." [GO:0007095, PomBase:mah] synonym: "abnormal G2 DNA damage checkpoint during mitotic cell cycle" EXACT [PomBase:mah] synonym: "abnormal mitotic cell cycle G2/M transition DNA damage checkpoint" EXACT [GO:0007095] synonym: "abnormal mitotic G2 DNA damage checkpoint activation" RELATED [PomBase:mah] synonym: "abnormal mitotic G2 DNA damage checkpoint during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000006 ! abnormal DNA damage checkpoint is_a: FYPO:0000166 ! abnormal regulation of G2/M transition of mitotic cell cycle intersection_of: PATO:0000001 ! quality intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0007095 ! mitotic G2 DNA damage checkpoint intersection_of: qualifier PATO:0000460 ! abnormal relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0007095 ! mitotic G2 DNA damage checkpoint relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-02-10T14:21:16Z [Term] id: FYPO:0004374 name: abolished protein localization to cytoplasm during glucose starvation def: "A cell phenotype in which the localization of a protein to the cytoplasm is abolished when the cell is subject to glucose starvation." [PomBase:al, PomBase:mah] synonym: "abolished protein localisation to cytoplasm during glucose starvation" EXACT [PomBase:mah] synonym: "abolished protein localization to cytoplasm during glucose depletion" EXACT [PomBase:mah] synonym: "abolished protein localization to cytoplasm during glucose deprivation" EXACT [PomBase:mah] synonym: "protein localization to cytoplasm abolished during glucose starvation" EXACT [PomBase:mah] is_a: FYPO:0001375 ! protein localization abolished created_by: midori creation_date: 2015-02-12T11:09:56Z [Term] id: FYPO:0004375 name: sensitive to Ku-0063794 def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to Ku-0063794. Cells stop growing (and may die) at a concentration of Ku-0063794 that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to Ku-0063794" EXACT [PomBase:mah] synonym: "sensitive to KU 0063794" EXACT [PomBase:al] synonym: "sensitive to Ku-0063794 during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to Ku-0063794 during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:85572 relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:85572 created_by: midori creation_date: 2015-02-12T11:28:29Z [Term] id: FYPO:0004376 name: increased chromatin silencing at silent mating-type cassette def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of chromatin silencing at the silent mating-type cassettes is increased." [PomBase:mah] synonym: "increased chromatin silencing at silent mating-type cassette during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased chromatin silencing at silent mating-type cassette during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0004540 ! increased chromatin silencing intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0030466 ! chromatin silencing at silent mating-type cassette relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0030466 ! chromatin silencing at silent mating-type cassette created_by: midori creation_date: 2015-02-12T11:31:31Z [Term] id: FYPO:0004377 name: increased protein localization to mating-type region heterochromatin def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to heterochromatin at the silenced mating-type region is increased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to heterochromatin at mating-type region" EXACT [PomBase:mah] synonym: "increased protein localization to heterochromatin at mating-type region" EXACT [PomBase:mah] synonym: "increased protein localization to heterochromatin at mating-type region during vegetative growth" EXACT [PomBase:mah] synonym: "increased protein localization to mating-type region heterochromatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein localization to mating-type region heterochromatin during vegetative growth" EXACT [PomBase:al] synonym: "increased protein localization to silent mating type heterochromatin" EXACT [PomBase:al] is_a: FYPO:0001131 ! abnormal protein localization to heterochromatin during vegetative growth is_a: FYPO:0003011 ! increased protein localization to chromatin intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903212 ! protein localization to mating-type region heterochromatin relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903212 ! protein localization to mating-type region heterochromatin created_by: midori creation_date: 2015-02-12T11:56:51Z [Term] id: FYPO:0004378 name: normal protein localization to mating-type region heterochromatin def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to heterochromatin at the silenced mating-type region is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to heterochromatin at mating-type region" EXACT [PomBase:mah] synonym: "normal protein localization to heterochromatin at mating-type region" EXACT [PomBase:mah] synonym: "normal protein localization to heterochromatin at mating-type region during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein localization to mating-type region heterochromatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to mating-type region heterochromatin during vegetative growth" EXACT [PomBase:al] synonym: "normal protein localization to silent mating type heterochromatin" EXACT [PomBase:al] is_a: FYPO:0001509 ! normal protein localization to chromatin intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903212 ! protein localization to mating-type region heterochromatin intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903212 ! protein localization to mating-type region heterochromatin relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-02-12T11:59:22Z [Term] id: FYPO:0004379 name: increased protein localization to subtelomeric heterochromatin def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to heterochromatin in subtelomeric regions is increased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to subtelomeric heterochromatin" EXACT [PomBase:mah] synonym: "increased protein localization to heterochromatin at subtelomere" EXACT [PomBase:mah] synonym: "increased protein localization to subtelomeric heterochromatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein localization to subtelomeric heterochromatin during vegetative growth" EXACT [PomBase:al] is_a: FYPO:0001131 ! abnormal protein localization to heterochromatin during vegetative growth is_a: FYPO:0003011 ! increased protein localization to chromatin intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903213 ! protein localization to subtelomeric heterochromatin relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903213 ! protein localization to subtelomeric heterochromatin created_by: midori creation_date: 2015-02-12T12:07:43Z [Term] id: FYPO:0004380 name: increased protein localization to pericentric heterochromatin def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to heterochromatin in pericentric regions is increased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to pericentric heterochromatin" EXACT [PomBase:mah] synonym: "increased protein localization to nuclear pericentric heterochromatin" EXACT [GO:1902682] synonym: "increased protein localization to pericentric heterochromatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein localization to pericentric heterochromatin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000451 ! increased protein localization to centromere is_a: FYPO:0001130 ! increased protein localization to nucleus during vegetative growth is_a: FYPO:0003011 ! increased protein localization to chromatin intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902682 ! protein localization to nuclear pericentric heterochromatin relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902682 ! protein localization to nuclear pericentric heterochromatin created_by: midori creation_date: 2015-02-12T12:09:55Z [Term] id: FYPO:0004381 name: merotelic kinetochore attachment during mitosis def: "A cellular process phenotype in which the attachment of spindle microtubules to the kinetochore during a mitotic or nuclear division results in the connection of a single kinetochore to both spindle poles." [PMID:17426725, PMID:21306900, PomBase:mah] synonym: "merotelic attachment of spindle microtubules to kinetochore during mitosis" EXACT [PomBase:mah] synonym: "merotelic kinetochore attachment during mitotic M phase" EXACT [PomBase:mah] synonym: "merotelic kinetochore attachment during mitotic nuclear division" EXACT [GO:0007067] is_a: FYPO:0002651 ! merotelic kinetochore attachment is_a: FYPO:0004213 ! abnormal attachment of mitotic spindle microtubules to kinetochore created_by: midori creation_date: 2015-02-12T13:14:50Z [Term] id: FYPO:0004382 name: meroterically attached lagging mitotic chromosomes def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which a single kinetochore becomes attached to both spindle poles, and sister chromatids do not move towards the spindle poles at the same time during mitosis prior to completion of chromosome segregation." [PMID:20935472, PomBase:mah] synonym: "abnormal mitotic sister chromatid segregation, with merotelic kinetochore attachment and lagging mitotic chromosomes" EXACT [PomBase:mah] synonym: "lagging mitotic chromosomes with merotelic kinetochore attachment" EXACT [PomBase:mah] synonym: "lagging mitotic sister chromatids, with merotelic kinetochore attachment" EXACT [PomBase:mah] synonym: "merotelic kinetochore attachment with lagging mitotic chromosomes" EXACT [PomBase:mah] synonym: "meroterically attached lagging mitotic chromosomes during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000141 ! abnormal mitotic sister chromatid segregation relationship: has_part FYPO:0000228 ! lagging mitotic chromosomes relationship: has_part FYPO:0004381 ! merotelic kinetochore attachment during mitosis created_by: midori creation_date: 2015-02-12T13:17:18Z [Term] id: FYPO:0004383 name: premature protein localization to mitotic spindle def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the mitotic spindle begins earlier than normal." [PMID:20935472, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "advanced protein localization to mitotic spindle" EXACT [PomBase:mah] synonym: "precocious protein localization to mitotic spindle" RELATED [PATO:0000694, PMID:20935472] synonym: "premature protein localisation to mitotic spindle" EXACT [PomBase:mah] synonym: "premature protein localization to spindle during mitosis" EXACT [PomBase:mah] synonym: "premature protein localization to spindle during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002824 ! abnormal protein localization to mitotic spindle is_a: PATO:0000694 ! premature intersection_of: PATO:0000694 ! premature intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902480 ! protein localization to mitotic spindle relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902480 ! protein localization to mitotic spindle created_by: midori creation_date: 2015-02-12T13:24:05Z [Term] id: FYPO:0004384 name: normal single-stranded DNA binding def: "A molecular function phenotype in which occurrence of single-stranded DNA binding by a gene product is normal (i.e. indistinguishable from wild type). The relevant gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "normal ssDNA binding" EXACT [GO:0003697] is_a: FYPO:0000655 ! normal DNA binding intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0003697 ! single-stranded DNA binding intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0003697 ! single-stranded DNA binding relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-02-12T16:23:46Z [Term] id: FYPO:0004385 name: decreased single-stranded DNA binding def: "A molecular function phenotype in which occurrence of single-stranded DNA binding by a gene product is decreased, when a gene or the bound DNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "decreased ssDNA binding" EXACT [GO:0003697] synonym: "reduced single-stranded DNA binding" EXACT [PomBase:mah] is_a: FYPO:0000658 ! decreased DNA binding intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0003697 ! single-stranded DNA binding relationship: inheres_in GO:0003697 ! single-stranded DNA binding created_by: midori creation_date: 2015-02-12T16:25:06Z [Term] id: FYPO:0004386 name: abolished single-stranded DNA binding def: "A molecular function phenotype in which single-stranded DNA binding by a gene product does not occur, when a gene or the bound DNA sequence is mutated. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] synonym: "abolished ssDNA binding" EXACT [GO:0003697] synonym: "single-stranded DNA binding abolished" EXACT [PomBase:mah] is_a: FYPO:0000659 ! abolished DNA binding intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0003697 ! single-stranded DNA binding relationship: towards GO:0003697 ! single-stranded DNA binding created_by: midori creation_date: 2015-02-12T16:25:42Z [Term] id: FYPO:0004387 name: decreased positive regulation of DNA-directed DNA polymerase activity def: "A regulation phenotype observed in the vegetative growth phase of the life cycle in which positive regulation of DNA-directed DNA polymerase activity occurs to a lower extent than normal." [PMID:14766746, PomBase:mah] synonym: "decreased activation of DNA-directed DNA polymerase activity" NARROW [GO:1900264] synonym: "decreased positive regulation of DNA polymerase activity" BROAD [PomBase:mah] synonym: "reduced positive regulation of DNA-directed DNA polymerase activity" EXACT [PomBase:mah] is_a: FYPO:0000682 ! abnormal regulation of molecular function is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:1900264 ! positive regulation of DNA-directed DNA polymerase activity relationship: inheres_in GO:1900264 ! positive regulation of DNA-directed DNA polymerase activity created_by: midori creation_date: 2015-02-12T16:28:05Z [Term] id: FYPO:0004388 name: increased level of pyrimidine salvage gene RNA during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more pyrimidine salvage RNAs measured in a cell is higher than normal (i.e. higher than observed in wild-type cells). Pyrimidine salvage RNAs are transcribed from genes whose products are involved in pyrimidine salvage." [PMID:23695302, PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "increased level of pyrimidine salvage gene RNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased level of pyrimidine salvage gene transcripts during vegetative growth" EXACT [PomBase:vw] synonym: "increased pyrimidine salvage gene RNA accumulation during vegetative growth" RELATED [PomBase:mah] is_a: FYPO:0000825 ! increased RNA level during vegetative growth created_by: midori creation_date: 2015-02-12T16:35:02Z [Term] id: FYPO:0004389 name: increased level of amino acid catabolism gene RNA during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more amino acid catabolism RNAs measured in a cell is higher than normal (i.e. higher than observed in wild-type cells). Amino acid catabolism RNAs are transcribed from genes whose products are involved in amino acid catabolism." [PMID:23695302, PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "increased amino acid catabolism gene RNA accumulation during vegetative growth" RELATED [PomBase:mah] synonym: "increased level of amino acid catabolism gene RNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased level of amino acid catabolism gene transcripts during vegetative growth" EXACT [PomBase:vw] is_a: FYPO:0002743 ! increased level of amino acid metabolism gene RNA during vegetative growth created_by: midori creation_date: 2015-02-12T16:37:09Z [Term] id: FYPO:0004390 name: increased level of arginine catabolism gene RNA during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more arginine catabolism RNAs measured in a cell is higher than normal (i.e. higher than observed in wild-type cells). Arginine catabolism RNAs are transcribed from genes whose products are involved in arginine catabolism." [PMID:23695302, PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "increased arginine catabolism gene RNA accumulation during vegetative growth" RELATED [PomBase:mah] synonym: "increased level of arginine catabolism gene RNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased level of arginine catabolism gene transcripts during vegetative growth" EXACT [PomBase:vw] is_a: FYPO:0004389 ! increased level of amino acid catabolism gene RNA during vegetative growth created_by: midori creation_date: 2015-02-12T16:38:01Z [Term] id: FYPO:0004391 name: abolished cell population growth on uracil nitrogen source def: "A vegetative cell population growth phenotype in which a cell population does not grow in a medium containing uracil as the nitrogen source." [PomBase:mah] comment: Use this term for a population of cells that does not grow with uracil as the nitrogen source, but does grow using a different nitrogen source (a cell population that does not grow on any media would be considered inviable). Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "abolished growth on uracil nitrogen source" BROAD [PomBase:mah] synonym: "abolished uracil utilization" RELATED [PomBase:mah, PomBase:vw] synonym: "abolished vegetative cell population growth on uracil nitrogen source" EXACT [PomBase:mah] synonym: "cell population growth on uracil nitrogen source abolished" EXACT [PomBase:mah] is_a: FYPO:0001575 ! abolished vegetative cell population growth created_by: midori creation_date: 2015-02-12T16:39:43Z [Term] id: FYPO:0004392 name: abolished positive regulation of DNA-directed DNA polymerase activity def: "A regulation phenotype observed in the vegetative growth phase of the life cycle in which positive regulation of DNA-directed DNA polymerase activity does not occur." [PMID:14766746, PomBase:mah] synonym: "abolished activation of DNA-directed DNA polymerase activity" NARROW [GO:1900264] synonym: "positive regulation of DNA-directed DNA polymerase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000682 ! abnormal regulation of molecular function is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1900264 ! positive regulation of DNA-directed DNA polymerase activity relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1900264 ! positive regulation of DNA-directed DNA polymerase activity created_by: midori creation_date: 2015-02-12T16:49:04Z [Term] id: FYPO:0004393 name: lagging chromosomes during meiosis I def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which homologous chromosomes or sister chromatids do not move towards the spindle poles at the same time during meiosis I, but instead one or more chromosomes remain distant from the spindle pole after the bulk of the DNA has separated. Segregation may stop before completing separation of chromosomes, or may eventually be completed." [PomBase:mah] synonym: "lagging chromosomes during first meiotic nuclear division" EXACT [PomBase:mah] is_a: FYPO:0002091 ! lagging meiotic chromosomes created_by: midori creation_date: 2015-02-17T12:22:32Z [Term] id: FYPO:0004394 name: lagging chromosomes during meiosis II def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which homologous chromosomes or sister chromatids do not move towards the spindle poles at the same time during meiosis II, but instead one or more chromosomes remain distant from the spindle pole after the bulk of the DNA has separated. Segregation may stop before completing separation of chromosomes, or may eventually be completed." [PomBase:mah] synonym: "lagging chromosomes during second meiotic nuclear division" EXACT [PomBase:mah] is_a: FYPO:0002091 ! lagging meiotic chromosomes created_by: midori creation_date: 2015-02-17T12:23:19Z [Term] id: FYPO:0004395 name: short mitotic spindle during metaphase def: "A spindle phenotype in which the mitotic spindle is shorter than normal during metaphase." [PomBase:mah] synonym: "decreased mitotic spindle length during metaphase" EXACT [PomBase:mah] synonym: "short bipolar mitotic spindle during metaphase" EXACT [PomBase:vw] synonym: "short mitotic spindle during metaphase during vegetative growth" EXACT [PomBase:mah] synonym: "short mitotic spindles during metaphase" EXACT [PomBase:mah] synonym: "short spindle during mitotic metaphase" EXACT [PomBase:mah] is_a: FYPO:0000732 ! short mitotic spindle intersection_of: PATO:0000574 ! decreased length intersection_of: exists_during GO:0000089 ! mitotic metaphase intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072686 ! mitotic spindle relationship: exists_during GO:0000089 ! mitotic metaphase relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072686 ! mitotic spindle created_by: midori creation_date: 2015-02-17T14:17:40Z [Term] id: FYPO:0004396 name: normal mitotic spindle elongation def: "A spindle phenotype in which mitotic spindle elongation, i.e. the process of lengthening the distance between poles of the mitotic spindle, is normal (i.e. indistinguishable from wild type)." [GO:0000022, PomBase:mah] synonym: "normal mitotic spindle elongation during vegetative growth" EXACT [PomBase:mah] synonym: "normal spindle elongation during mitosis" EXACT [PomBase:mah] is_a: FYPO:0002741 ! normal mitotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000022 ! mitotic spindle elongation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000022 ! mitotic spindle elongation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-02-17T14:40:51Z [Term] id: FYPO:0004397 name: normal protein export from nucleus def: "A transport phenotype observed in the vegetative growth phase of the life cycle in which the export of protein from the nucleus is normal (i.e. indistinguishable from wild type). Export of all proteins or a specific protein may be assayed." [PomBase:mah] synonym: "normal protein export from nucleus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein export from nucleus during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000509 ! normal nuclear export intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006611 ! protein export from nucleus intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006611 ! protein export from nucleus relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-02-17T14:47:14Z [Term] id: FYPO:0004398 name: resistance to phenylarsine oxide def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of phenylarsine oxide than normal." [PomBase:mah] synonym: "resistance to phenylarsine oxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to phenylarsine oxide during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to phenylarsine oxide" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:75253 ! phenylarsine oxide relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:75253 ! phenylarsine oxide created_by: midori creation_date: 2015-02-17T14:50:01Z [Term] id: FYPO:0004399 name: normal growth on KT5720 def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing the protein kinase inhibitor KT5720." [PomBase:mah] synonym: "normal cell population growth in presence of KT5720" EXACT [PomBase:mah] synonym: "normal cell population growth on KT5720" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to KT5720" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on KT5720" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:85085 relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:85085 created_by: midori creation_date: 2015-02-17T15:03:10Z [Term] id: FYPO:0004400 name: normal growth on KT5823 def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing the protein kinase inhibitor KT5823." [PomBase:mah] synonym: "normal cell population growth in presence of KT5823" EXACT [PomBase:mah] synonym: "normal cell population growth on KT5823" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to KT5823" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on KT5823" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:85113 relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:85113 created_by: midori creation_date: 2015-02-17T15:04:00Z [Term] id: FYPO:0004401 name: normal growth on KT5926 def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing the protein kinase inhibitor KT5926." [PomBase:mah] synonym: "normal cell population growth in presence of KT5926" EXACT [PomBase:mah] synonym: "normal cell population growth on KT5926" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to KT5926" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on KT5926" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:78763 ! EC 2.7.11.18 (myosin-light-chain kinase) inhibitor relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:78763 ! EC 2.7.11.18 (myosin-light-chain kinase) inhibitor created_by: midori creation_date: 2015-02-17T15:04:37Z [Term] id: FYPO:0004402 name: sensitive to JM216 def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to JM216 (also called satraplatin). Cells stop growing (and may die) at a concentration of JM216 that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to JM216" EXACT [PomBase:mah] synonym: "sensitive to JM216 during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to JM216 during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to satraplatin" EXACT [CHEBI:85609, PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:85609 relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:85609 created_by: midori creation_date: 2015-02-17T15:19:23Z [Term] id: FYPO:0004403 name: resistance to JM216 def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of JM216 (also called satraplatin) than normal." [PomBase:mah] synonym: "resistance to JM216 during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to JM216 during vegetative growth" EXACT [PomBase:mah] synonym: "resistance to satraplatin" EXACT [PomBase:mah] synonym: "resistant to JM216" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:85609 relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:85609 created_by: midori creation_date: 2015-02-17T15:31:56Z [Term] id: FYPO:0004404 name: normal growth on JM216 def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing JM216 (also called satraplatin)." [PomBase:mah] synonym: "normal cell population growth in presence of JM216" EXACT [PomBase:mah] synonym: "normal cell population growth on JM216" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cell population growth on satraplatin" EXACT [PomBase:mah] synonym: "normal cellular response to JM216" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on JM216" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:85609 relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:85609 created_by: midori creation_date: 2015-02-17T15:32:53Z [Term] id: FYPO:0004405 name: sensitive to JM335 def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to JM335. Cells stop growing (and may die) at a concentration of JM335 that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to JM335" EXACT [PomBase:mah] synonym: "sensitive to JM335 during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to JM335 during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:85610 relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:85610 created_by: midori creation_date: 2015-02-17T15:40:47Z [Term] id: FYPO:0004406 name: normal growth on JM335 def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing JM335." [PomBase:mah] synonym: "normal cell population growth in presence of JM335" EXACT [PomBase:mah] synonym: "normal cell population growth on JM335" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to JM335" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on JM335" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:85610 relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:85610 created_by: midori creation_date: 2015-02-17T15:42:00Z [Term] id: FYPO:0004407 name: sensitive to triplatin tetranitrate def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to triplatin tetranitrate (also called BBR 3464). Cells stop growing (and may die) at a concentration of triplatin tetranitrate that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to triplatin tetranitrate" EXACT [PomBase:mah] synonym: "sensitive to BBR 3464" EXACT [PomBase:mah] synonym: "sensitive to triplatin tetranitrate during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to triplatin tetranitrate during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:85611 relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:85611 created_by: midori creation_date: 2015-02-17T15:43:49Z [Term] id: FYPO:0004408 name: normal growth on triplatin tetranitrate def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing triplatin tetranitrate (also called BBR 3464)." [PomBase:mah] synonym: "normal cell population growth in presence of triplatin tetranitrate" EXACT [PomBase:mah] synonym: "normal cell population growth on BBR 3464" EXACT [PomBase:mah] synonym: "normal cell population growth on triplatin tetranitrate" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to triplatin tetranitrate" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on triplatin tetranitrate" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:85611 relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:85611 created_by: midori creation_date: 2015-02-17T15:47:54Z [Term] id: FYPO:0004409 name: sensitive to tetraplatin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to tetraplatin. Cells stop growing (and may die) at a concentration of tetraplatin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to tetraplatin" EXACT [PomBase:mah] synonym: "sensitive to tetraplatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to tetraplatin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:85577 relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:85577 created_by: midori creation_date: 2015-02-17T15:51:03Z [Term] id: FYPO:0004410 name: normal growth on tetraplatin def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing tetraplatin." [PomBase:mah] synonym: "normal cell population growth in presence of tetraplatin" EXACT [PomBase:mah] synonym: "normal cell population growth on tetraplatin" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to tetraplatin" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on tetraplatin" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:85577 relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:85577 created_by: midori creation_date: 2015-02-17T15:52:00Z [Term] id: FYPO:0004411 name: normal growth on oxaliplatin def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing oxaliplatin." [PomBase:mah] synonym: "normal cell population growth in presence of oxaliplatin" EXACT [PomBase:mah] synonym: "normal cell population growth on oxaliplatin" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cellular response to oxaliplatin" RELATED [PomBase:al, PomBase:mah] synonym: "normal vegetative cell population growth on oxaliplatin" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:31941 ! oxaliplatin relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:31941 ! oxaliplatin created_by: midori creation_date: 2015-02-17T15:52:29Z [Term] id: FYPO:0004412 name: abolished protein localization to mitotic spindle midzone during anaphase def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the mitotic spindle midzone during anaphase does not occur. The mitotic spindle midzone is the area in the center of the mitotic spindle where the spindle microtubules from opposite poles overlap. Anaphase is the stage of mitosis in which chromosomes separate and migrate towards the poles of the spindle." [GO:0000090, GO:1902967, GO:1990023, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "protein absent from mitotic spindle midzone during anaphase" RELATED [PomBase:mah] synonym: "protein localisation to mitotic spindle midzone abolished during anaphase" EXACT [PomBase:mah] synonym: "protein localization to mitotic spindle midzone abolished during anaphase" EXACT [PomBase:mah] synonym: "protein localization to spindle midzone abolished during anaphase during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003484 ! abolished protein localization to mitotic spindle midzone intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0000090 ! mitotic anaphase intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1902967 ! protein localization to mitotic spindle midzone relationship: during GO:0000090 ! mitotic anaphase relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1902967 ! protein localization to mitotic spindle midzone created_by: midori creation_date: 2015-02-17T16:00:11Z [Term] id: FYPO:0004413 name: decreased phosphatase activity during cellular response to phosphate starvation def: "A molecular function phenotype in which the observed rate of a phosphatase activity is decreased during a cellular response to phosphate starvation." [PomBase:mah] synonym: "decreased phosphatase activity during phosphate starvation" EXACT [PomBase:al] synonym: "reduced phosphatase activity during cellular response to phosphate starvation" EXACT [PomBase:mah] is_a: FYPO:0004304 ! decreased phosphatase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: during GO:0016036 ! cellular response to phosphate starvation intersection_of: inheres_in GO:0016791 ! phosphatase activity relationship: during GO:0016036 ! cellular response to phosphate starvation relationship: inheres_in GO:0016791 ! phosphatase activity created_by: midori creation_date: 2015-02-17T16:15:43Z [Term] id: FYPO:0004414 name: increased phosphatase activity during cellular response to phosphate starvation def: "A molecular function phenotype in which the observed rate of a phosphatase activity is increased during a cellular response to phosphate starvation." [PomBase:mah] synonym: "increased phosphatase activity during phosphate starvation" EXACT [PomBase:al] is_a: FYPO:0004415 ! increased phosphatase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: during GO:0016036 ! cellular response to phosphate starvation intersection_of: inheres_in GO:0016791 ! phosphatase activity relationship: during GO:0016036 ! cellular response to phosphate starvation relationship: inheres_in GO:0016791 ! phosphatase activity created_by: midori creation_date: 2015-02-17T16:16:42Z [Term] id: FYPO:0004415 name: increased phosphatase activity def: "A molecular function phenotype in which the observed rate of a phosphatase activity is increased." [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0004302 ! abnormal phosphatase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0016791 ! phosphatase activity relationship: inheres_in GO:0016791 ! phosphatase activity created_by: midori creation_date: 2015-02-17T16:17:01Z [Term] id: FYPO:0004416 name: decreased RNA level during cellular response to phosphate starvation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to phosphate starvation is lower than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased mRNA level during cellular response to phosphate starvation" NARROW [PomBase:mah] synonym: "decreased RNA accumulation during cellular response to phosphate starvation" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to phosphate depletion" EXACT [PomBase:vw] synonym: "decreased RNA level during cellular response to phosphate deprivation" EXACT [PomBase:vw] synonym: "decreased RNA level during cellular response to phosphate starvation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to phosphate starvation during vegetative growth" EXACT [PomBase:mah] synonym: "decreased RNA level during phosphate starvation" EXACT [PomBase:al] synonym: "decreased transcript level during cellular response to phosphate starvation" EXACT [PomBase:vw] synonym: "reduced RNA level during cellular response to phosphate starvation" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth is_a: FYPO:0003195 ! altered RNA level during cellular response to phosphate starvation intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0016036 ! cellular response to phosphate starvation intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0016036 ! cellular response to phosphate starvation relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2015-02-17T16:29:12Z [Term] id: FYPO:0004417 name: normal RNA level during cellular response to phosphate starvation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to phosphate starvation is normal (i.e. indistinguishable from wild type). Total RNA or a specific RNA may be affected." [PomBase:mah] comment: We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "normal mRNA level during cellular response to phosphate starvation" NARROW [PomBase:mah] synonym: "normal RNA accumulation during cellular response to phosphate starvation" RELATED [PomBase:mah] synonym: "normal RNA level during cellular response to phosphate starvation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal RNA level during cellular response to phosphate starvation during vegetative growth" EXACT [PomBase:mah] synonym: "normal RNA level during phosphate starvation" EXACT [PomBase:al] is_a: FYPO:0001317 ! normal RNA level during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0016036 ! cellular response to phosphate starvation intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0016036 ! cellular response to phosphate starvation relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2015-02-17T16:31:11Z [Term] id: FYPO:0004418 name: cut cell with decreased poly(A)+ mRNA export from nucleus def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell undergoes septation despite abnormal chromosome segregation, such that the septum physically divides the nucleus into two parts, and in which the export of polyadenylated mRNA from the nucleus is decreased. The daughter cells produced by septation are both inviable. Export of all polyadenylated mRNAs or a specific mRNA may be affected." [PMID:14511667, PomBase:mah, PomBase:vw] synonym: "cut cell with reduced poly(A)+ mRNA export from nucleus" EXACT [PomBase:mah] synonym: "cut with decreased poly(A)+ mRNA export from nucleus" EXACT [PomBase:mah] synonym: "decreased poly(A) mRNA export in cut" EXACT [PomBase:vw] is_a: FYPO:0003755 ! abnormal vegetative cell phenotype intersection_of: FYPO:0003755 ! abnormal vegetative cell phenotype intersection_of: has_part FYPO:0002522 ! decreased poly(A)+ mRNA export from nucleus intersection_of: has_part FYPO:0003165 ! cut relationship: has_part FYPO:0002522 ! decreased poly(A)+ mRNA export from nucleus relationship: has_part FYPO:0003165 ! cut created_by: midori creation_date: 2015-02-19T11:10:36Z [Term] id: FYPO:0004419 name: abolished protein localization to cytoplasm with increased protein localization to nucleus def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the cytoplasm is abolished, and the protein is instead present in the nucleus at a greater level than normal." [PMID:17362205, PomBase:al, PomBase:mah] synonym: "abolished protein localisation to cytoplasm with increased protein localisation to nucleus" RELATED [PomBase:mah] synonym: "abolished protein localization to cytoplasm with increased protein localization to nucleus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to cytoplasm with increased protein localization to nucleus during vegetative growth" EXACT [PomBase:mah] synonym: "protein localization to cytoplasm abolished with increased protein localization to nucleus" EXACT [PomBase:mah] is_a: FYPO:0001179 ! protein localization abolished during vegetative growth created_by: midori creation_date: 2015-02-19T11:29:22Z [Term] id: FYPO:0004420 name: increased protein serine phosphorylation def: "A cellular process phenotype in which the phosphorylation of serine residues in one or more specific proteins, or of specific protein sites, occurs to a greater extent than normal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased peptidyl-serine phosphorylation" EXACT [GO:0018105, PomBase:mah] synonym: "increased serine phosphorylation" EXACT [PomBase:al] is_a: FYPO:0002680 ! increased protein phosphorylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0018105 ! peptidyl-serine phosphorylation relationship: inheres_in GO:0018105 ! peptidyl-serine phosphorylation created_by: midori creation_date: 2015-02-19T11:38:00Z [Term] id: FYPO:0004421 name: increased protein serine phosphorylation during nitrogen starvation def: "A cellular process phenotype in which the phosphorylation of serine residues in one or more specific proteins, or of specific protein sites, occurs to a greater extent than normal when the cell is subject to nitrogen starvation." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased peptidyl-serine phosphorylation during nitrogen starvation" EXACT [GO:0018105, PomBase:mah] synonym: "increased protein serine phosphorylation during cellular response to nitrogen starvation" EXACT [PomBase:mah] synonym: "increased protein serine phosphorylation during nitrogen depletion" EXACT [PomBase:mah] synonym: "increased protein serine phosphorylation during nitrogen deprivation" EXACT [PomBase:mah] synonym: "increased serine phosphorylation during nitrogen starvation" EXACT [PomBase:al] is_a: FYPO:0002681 ! increased protein phosphorylation during nitrogen starvation is_a: FYPO:0004420 ! increased protein serine phosphorylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in GO:0018105 ! peptidyl-serine phosphorylation relationship: happens_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in GO:0018105 ! peptidyl-serine phosphorylation created_by: midori creation_date: 2015-02-19T11:46:24Z [Term] id: FYPO:0004422 name: normal protein phosphorylation def: "A cellular process phenotype in which the phosphorylation of one or more specific proteins is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. is_a: FYPO:0002495 ! normal protein modification intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0006468 ! protein phosphorylation intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0006468 ! protein phosphorylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-02-19T11:48:19Z [Term] id: FYPO:0004423 name: normal protein threonine phosphorylation def: "A cellular process phenotype in which the phosphorylation of threonine residues of one or more specific proteins is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal peptidyl-threonine phosphorylation" EXACT [GO:0018107] is_a: FYPO:0004422 ! normal protein phosphorylation intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0018107 ! peptidyl-threonine phosphorylation intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0018107 ! peptidyl-threonine phosphorylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-02-19T11:49:56Z [Term] id: FYPO:0004424 name: increased protein threonine phosphorylation def: "A cellular process phenotype in which the phosphorylation of threonine residues in one or more specific proteins, or of specific protein sites, occurs to a greater extent than normal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased peptidyl-threonine phosphorylation" EXACT [GO:0018107, PomBase:mah] synonym: "increased threonine phosphorylation" EXACT [PomBase:al] is_a: FYPO:0002680 ! increased protein phosphorylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0018107 ! peptidyl-threonine phosphorylation relationship: inheres_in GO:0018107 ! peptidyl-threonine phosphorylation created_by: midori creation_date: 2015-02-19T11:53:50Z [Term] id: FYPO:0004425 name: abolished protein threonine phosphorylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of threonine residues in one or more specific proteins, or of specific protein sites, does not occur." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished peptidyl-threonine phosphorylation" EXACT [GO:0018107] synonym: "protein threonine phosphorylation abolished" EXACT [PomBase:mah] is_a: FYPO:0002678 ! abolished protein phosphorylation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0018107 ! peptidyl-threonine phosphorylation relationship: towards GO:0018107 ! peptidyl-threonine phosphorylation created_by: midori creation_date: 2015-02-19T11:54:57Z [Term] id: FYPO:0004426 name: abnormal protein dephosphorylation def: "A cellular process phenotype in which the dephosphorylation of one or more specific proteins is abnormal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. is_a: FYPO:0002494 ! abnormal protein modification intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0006470 ! protein dephosphorylation intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0006470 ! protein dephosphorylation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-02-19T14:17:17Z [Term] id: FYPO:0004427 name: delayed ribosomal S6 protein dephosphorylation during cellular response to nitrogen starvation def: "A cellular process phenotype in which the dephosphorylation of the ribosomal small subunit protein S6 begins later than normal when the cell is subject to nitrogen starvation." [PMID:24247430, PomBase:mah] synonym: "delayed dephosphorylation of ribosomal S6 during cellular response to nitrogen starvation" EXACT [PomBase:mah] synonym: "delayed ribosomal S6 dephosphorylation during cellular response to nitrogen starvation" EXACT [PomBase:al] is_a: FYPO:0004426 ! abnormal protein dephosphorylation created_by: midori creation_date: 2015-02-19T14:21:45Z [Term] id: FYPO:0004428 name: increased rate of cytokinesis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the rate, or speed, of mitotic cytokinesis is increased." [PomBase:mah] synonym: "increased rate of cytokinesis during vegetative growth" EXACT [PomBase:mah] synonym: "increased rate of mitotic cytokinesis" EXACT [GO:0000281, PomBase:mah] is_a: FYPO:0000032 ! abnormal cytokinesis is_a: PATO:0000912 ! increased rate intersection_of: PATO:0000912 ! increased rate intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000281 ! mitotic cytokinesis relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000281 ! mitotic cytokinesis created_by: midori creation_date: 2015-02-19T14:29:27Z [Term] id: FYPO:0004429 name: normal rate of mitotic spindle elongation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the rate, or speed, of mitotic spindle elongation is normal (i.e. indistinguishable from wild type)." [PMID:19029336, PomBase:mah] synonym: "normal mitotic spindle elongation rate" EXACT [PomBase:mah] synonym: "normal rate of mitotic spindle elongation during vegetative growth" EXACT [PomBase:mah] synonym: "normal rate of spindle elongation during mitosis" EXACT [PomBase:mah] is_a: FYPO:0004396 ! normal mitotic spindle elongation is_a: PATO:0000161 ! rate intersection_of: PATO:0000161 ! rate intersection_of: inheres_in GO:0000022 ! mitotic spindle elongation intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0000022 ! mitotic spindle elongation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-02-19T14:31:51Z [Term] id: FYPO:0004430 name: premature actomyosin contractile ring contraction def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which actomyosin contractile ring contraction begins earlier than normal, e.g. before the mitotic spindle has completely disassembled. Contractile ring contraction is the part of cytokinesis in which the actomyosin contractile ring constricts." [GO:1902404, PMID:19029336, PomBase:mah] synonym: "advanced actomyosin contractile ring contraction" EXACT [PomBase:mah] synonym: "premature actomyosin contractile ring constriction" EXACT [PomBase:mah] synonym: "premature actomyosin contractile ring contraction during vegetative growth" EXACT [PomBase:mah] synonym: "premature contractile ring contraction" EXACT [PomBase:vw] synonym: "premature cytokinetic contractile ring contraction" EXACT [PomBase:vw] synonym: "premature mitotic actomyosin contractile ring contraction" EXACT [GO:1902404, PomBase:mah] synonym: "premature mitotic contractile ring contraction" EXACT [PomBase:vw] is_a: FYPO:0001364 ! abnormal actomyosin contractile ring contraction is_a: PATO:0000694 ! premature intersection_of: PATO:0000694 ! premature intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902404 ! mitotic actomyosin contractile ring contraction relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902404 ! mitotic actomyosin contractile ring contraction created_by: midori creation_date: 2015-02-19T14:35:04Z [Term] id: FYPO:0004431 name: sensitive to 2-bromo-2-(((4-methylphenyl)sulfonyl)methyl)-1-indanone def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to 2-bromo-2-(((4-methylphenyl)sulfonyl)methyl)-1-indanone. Cells stop growing (and may die) at a concentration of 2-bromo-2-(((4-methylphenyl)sulfonyl)methyl)-1-indanone that allows wild type cells to grow." [PMID:18204818, PomBase:mah] synonym: "hypersensitive to 2-bromo-2-(((4-methylphenyl)sulfonyl)methyl)-1-indanone" EXACT [PomBase:mah] synonym: "sensitive to 2-bromo-2-(((4-methylphenyl)sulfonyl)methyl)-1-indanone during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to 2-bromo-2-(((4-methylphenyl)sulfonyl)methyl)-1-indanone during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:85613 relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:85613 created_by: midori creation_date: 2015-02-19T14:41:03Z [Term] id: FYPO:0004432 name: sensitive to 2-bromo-1-(4-methoxyphenyl)-3-((4-methylphenyl)sulfonyl)-1-propanone def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to 2-bromo-1-(4-methoxyphenyl)-3-((4-methylphenyl)sulfonyl)-1-propanone. Cells stop growing (and may die) at a concentration of 2-bromo-1-(4-methoxyphenyl)-3-((4-methylphenyl)sulfonyl)-1-propanone that allows wild type cells to grow." [PMID:18204818, PomBase:mah] synonym: "hypersensitive to 2-bromo-1-(4-methoxyphenyl)-3-((4-methylphenyl)sulfonyl)-1-propanone" EXACT [PomBase:mah] synonym: "sensitive to 2-bromo-1-(4-methoxyphenyl)-3-((4-methylphenyl)sulfonyl)-1-propanone during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to 2-bromo-1-(4-methoxyphenyl)-3-((4-methylphenyl)sulfonyl)-1-propanone during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:85615 relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:85615 created_by: midori creation_date: 2015-02-19T14:42:56Z [Term] id: FYPO:0004433 name: sensitive to viridicatumtoxin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to viridicatumtoxin. Cells stop growing (and may die) at a concentration of viridicatumtoxin that allows wild type cells to grow." [PMID:18204818, PomBase:mah] synonym: "hypersensitive to viridicatumtoxin" EXACT [PomBase:mah] synonym: "sensitive to viridicatumtoxin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to viridicatumtoxin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:85616 relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:85616 created_by: midori creation_date: 2015-02-19T14:43:41Z [Term] id: FYPO:0004434 name: sensitive to 4-amino-1-methyl-1H-imidazole-5-carboselenoamide def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to 4-amino-1-methyl-1H-imidazole-5-carboselenoamide. Cells stop growing (and may die) at a concentration of 4-amino-1-methyl-1H-imidazole-5-carboselenoamide that allows wild type cells to grow." [PMID:18204818, PomBase:mah] synonym: "hypersensitive to 4-amino-1-methyl-1H-imidazole-5-carboselenoamide" EXACT [PomBase:mah] synonym: "sensitive to 4-amino-1-methyl-1H-imidazole-5-carboselenoamide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to 4-amino-1-methyl-1H-imidazole-5-carboselenoamide during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:85619 relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:85619 created_by: midori creation_date: 2015-02-19T14:44:21Z [Term] id: FYPO:0004435 name: sensitive to tingenone def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to tingenone. Cells stop growing (and may die) at a concentration of tingenone that allows wild type cells to grow." [PMID:18204818, PomBase:mah] synonym: "hypersensitive to tingenone" EXACT [PomBase:mah] synonym: "sensitive to tingenone during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to tingenone during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:9602 ! Tingenone relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:9602 ! Tingenone created_by: midori creation_date: 2015-02-19T14:44:58Z [Term] id: FYPO:0004436 name: increased error-prone translesion synthesis def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which error-prone translesion synthesis occurs to a greater extent than normal. Error-prone translesion synthesis a DNA repair process that results in the conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication." [PMID:17515930, PomBase:mah] synonym: "increased DNA repair via error-prone translesion synthesis" EXACT [PomBase:al] synonym: "increased error-prone translesion synthesis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased error-prone translesion synthesis during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003892 ! abnormal error-prone translesion synthesis is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0042276 ! error-prone translesion synthesis relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0042276 ! error-prone translesion synthesis created_by: midori creation_date: 2015-02-19T15:18:27Z [Term] id: FYPO:0004437 name: normal mitotic recombination frequency def: "A cellular process phenotype in which the frequency of occurrence of mitotic recombination is normal (i.e. indistinguishable from wild type)." [PMID:17515930, PomBase:mah] synonym: "normal mitotic recombination frequency during vegetative growth" EXACT [PomBase:mah] synonym: "normal occurrence of mitotic recombination" EXACT [PomBase:mah] is_a: FYPO:0000503 ! normal mitotic recombination is_a: PATO:0000057 ! occurrence intersection_of: PATO:0000057 ! occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006312 ! mitotic recombination intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006312 ! mitotic recombination relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-02-19T15:24:04Z [Term] id: FYPO:0004438 name: long mitotic spindle during anaphase def: "A spindle phenotype in which the mitotic spindle is longer than normal during anaphase." [PMID:17352737, PomBase:mah] synonym: "elongated mitotic spindle during anaphase" EXACT [PomBase:mah] synonym: "increased mitotic spindle length during anaphase" EXACT [PomBase:vw] synonym: "long bipolar mitotic spindle during anaphase" EXACT [PomBase:vw] synonym: "long mitotic spindle during anaphase during vegetative growth" EXACT [PomBase:mah] synonym: "long mitotic spindles during anaphase" EXACT [PomBase:mah] synonym: "long spindle during anaphase of mitosis" EXACT [PomBase:mah] synonym: "long spindle during mitotic anaphase" EXACT [PomBase:mah] is_a: FYPO:0000733 ! long mitotic spindle intersection_of: PATO:0000573 ! increased length intersection_of: exists_during GO:0000090 ! mitotic anaphase intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072686 ! mitotic spindle relationship: exists_during GO:0000090 ! mitotic anaphase relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072686 ! mitotic spindle created_by: midori creation_date: 2015-02-19T15:28:58Z [Term] id: FYPO:0004439 name: long curved mitotic spindle during anaphase def: "A spindle phenotype in which the mitotic spindle is curved longer than normal during anaphase." [PMID:17352737, PomBase:mah] comment: In this phenotype, the spindle curves when it becomes longer than the long axis of the cell. synonym: "curved mitotic spindle with increased mitotic spindle length during anaphase" EXACT [PomBase:vw] synonym: "elongated curved mitotic spindle during anaphase" EXACT [PomBase:mah] synonym: "long curved bipolar mitotic spindle during anaphase" EXACT [PomBase:vw] synonym: "long curved mitotic spindle during anaphase during vegetative growth" EXACT [PomBase:mah] synonym: "long curved mitotic spindles during anaphase" EXACT [PomBase:mah] synonym: "long curved spindle during anaphase of mitosis" EXACT [PomBase:mah] synonym: "long curved spindle during mitotic anaphase" EXACT [PomBase:mah] synonym: "long mitotic spindle during anaphase, elongating beyond cell end resulting in long curved spindle" EXACT [PomBase:vw] is_a: FYPO:0000733 ! long mitotic spindle created_by: midori creation_date: 2015-02-19T15:34:08Z [Term] id: FYPO:0004440 name: normal cytosolic calcium level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of calcium ion measured in the cytosol is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cytosolic calcium accumulation" RELATED [PomBase:mah] synonym: "normal cytosolic calcium ion level" EXACT [PomBase:mah] synonym: "normal cytosolic calcium level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cytosolic calcium level during vegetative growth" EXACT [PomBase:mah] synonym: "normal levels of free cytosolic calcium" EXACT [PomBase:vw] is_a: FYPO:0001199 ! normal cellular calcium level is_a: FYPO:0001606 ! normal level of substance in cytosol intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005829 ! cytosol intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:29108 ! calcium(2+) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005829 ! cytosol relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:29108 ! calcium(2+) created_by: midori creation_date: 2015-02-19T15:54:52Z [Term] id: FYPO:0004441 name: decreased cytosolic calcium level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of calcium ion measured in the cytosol is lower than normal." [PomBase:mah] synonym: "decreased cytosolic calcium ion level" EXACT [PomBase:mah] synonym: "decreased cytosolic calcium ion level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased cytosolic calcium level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased level of calcium ions in cytosol" EXACT [PomBase:mah] synonym: "decreased levels of free cytosolic calcium" EXACT [PomBase:vw] synonym: "reduced cytosolic calcium level" EXACT [PomBase:mah] is_a: FYPO:0001197 ! decreased cellular calcium level is_a: FYPO:0001605 ! decreased level of substance in cytosol intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005829 ! cytosol intersection_of: towards CHEBI:29108 ! calcium(2+) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005829 ! cytosol relationship: towards CHEBI:29108 ! calcium(2+) created_by: midori creation_date: 2015-02-19T15:56:25Z [Term] id: FYPO:0004442 name: decreased protein localization to prospore membrane def: "A cell phenotype in which the localization of a protein to the prospore membrane is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to prospore membrane" EXACT [PomBase:mah] synonym: "decreased protein localization to forespore membrane" EXACT [PomBase:mah] synonym: "reduced protein localization to prospore membrane" EXACT [PomBase:mah] is_a: FYPO:0000677 ! abnormal protein localization to prospore membrane is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:1902657 ! protein localization to prospore membrane relationship: inheres_in GO:1902657 ! protein localization to prospore membrane created_by: midori creation_date: 2015-02-19T16:00:51Z [Term] id: FYPO:0004443 name: decreased protein localization to prospore membrane during meiosis II def: "A cell phenotype in which the localization of a protein to the prospore membrane is decreased during the second meiotic nuclear division." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to prospore membrane during meiosis II" EXACT [PomBase:mah] synonym: "decreased protein localization to forespore membrane during meiosis II" EXACT [PomBase:mah] synonym: "decreased protein localization to prospore membrane during second meiotic nuclear division" EXACT [PomBase:mah] synonym: "reduced protein localization to prospore membrane during meiosis II" EXACT [PomBase:mah] is_a: FYPO:0003549 ! abnormal protein localization during meiosis is_a: FYPO:0004442 ! decreased protein localization to prospore membrane intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0007135 ! meiosis II intersection_of: inheres_in GO:1902657 ! protein localization to prospore membrane relationship: happens_during GO:0007135 ! meiosis II relationship: inheres_in GO:1902657 ! protein localization to prospore membrane created_by: midori creation_date: 2015-02-19T16:03:02Z [Term] id: FYPO:0004444 name: decreased protein localization to prospore membrane during meiosis II with protein mislocalized to plasma membrane def: "A cell phenotype in which the localization of a protein to the prospore membrane is decreased, and the protein is instead present in the plasma membrane, during the second meiotic nuclear division." [PMID:21832151, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to prospore membrane during meiosis II with protein mislocalized to plasma membrane" EXACT [PomBase:mah] synonym: "decreased protein localization to forespore membrane during meiosis II with protein mislocalized to plasma membrane" EXACT [PomBase:mah] synonym: "decreased protein localization to prospore membrane during second meiotic nuclear division with protein mislocalized to plasma membrane" EXACT [PomBase:mah] synonym: "decreased protein localization to prospore membrane with protein mislocalized to plasma membrane during meiosis II" RELATED [PomBase:mah] synonym: "reduced protein localization to prospore membrane during meiosis II with protein mislocalized to plasma membrane" EXACT [PomBase:mah] is_a: FYPO:0003549 ! abnormal protein localization during meiosis is_a: FYPO:0004442 ! decreased protein localization to prospore membrane created_by: midori creation_date: 2015-02-19T16:04:24Z [Term] id: FYPO:0004445 name: abolished protein localization to prospore membrane during meiosis II with protein mislocalized to plasma membrane def: "A cell phenotype in which the localization of a protein to the prospore membrane does not occur, and the protein is instead present in the plasma membrane, during the second meiotic nuclear division." [PMID:21832151, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to prospore membrane during meiosis II with protein mislocalized to plasma membrane" EXACT [PomBase:mah] synonym: "abolished protein localization to forespore membrane during meiosis II with protein mislocalized to plasma membrane" EXACT [PomBase:mah] synonym: "abolished protein localization to prospore membrane during second meiotic nuclear division with protein mislocalized to plasma membrane" EXACT [PomBase:mah] synonym: "abolished protein localization to prospore membrane with protein mislocalized to plasma membrane during meiosis II" RELATED [PomBase:mah] synonym: "protein localization to prospore membrane abolished during meiosis II with protein mislocalized to plasma membrane" EXACT [PomBase:mah] is_a: FYPO:0000677 ! abnormal protein localization to prospore membrane is_a: FYPO:0001375 ! protein localization abolished is_a: FYPO:0003549 ! abnormal protein localization during meiosis created_by: midori creation_date: 2015-02-19T16:06:06Z [Term] id: FYPO:0004446 name: decreased endocytosis during meiotic cell cycle def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of endocytosis is decreased during the meiotic cell cycle. A phenotype may affect endocytosis of all cargoes, or of specific cargo such as a particular protein." [PomBase:mah] synonym: "reduced actin-mediated endocytosis during meiotic cell cycle" EXACT [PomBase:vw] synonym: "reduced endocytosis during meiotic cell cycle" EXACT [PomBase:mah] is_a: FYPO:0003886 ! abnormal endocytosis is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0051321 ! meiotic cell cycle intersection_of: inheres_in GO:0006897 ! endocytosis relationship: happens_during GO:0051321 ! meiotic cell cycle relationship: inheres_in GO:0006897 ! endocytosis created_by: midori creation_date: 2015-02-19T16:08:40Z [Term] id: FYPO:0004447 name: protein mislocalized to prospore membrane def: "A cell phenotype in which a protein that is not normally found in the prospore membrane is observed there." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "protein mislocalised to prospore membrane" EXACT [PomBase:mah] synonym: "protein mislocalized to forespore membrane" EXACT [PomBase:mah] is_a: FYPO:0003452 ! mislocalized protein intersection_of: PATO:0000628 ! mislocalised intersection_of: inheres_in CHEBI:36080 ! protein intersection_of: towards GO:0005628 ! prospore membrane relationship: inheres_in CHEBI:36080 ! protein relationship: towards GO:0005628 ! prospore membrane created_by: midori creation_date: 2015-02-19T16:13:35Z [Term] id: FYPO:0004448 name: mislocalized protein during meiotic cell cycle def: "A cell phenotype in which a protein is observed in a particular location where it is not normally found during the meiotic cell cycle." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "mislocalised protein during meiotic cell cycle" EXACT [PomBase:mah] is_a: FYPO:0003452 ! mislocalized protein intersection_of: PATO:0000628 ! mislocalised intersection_of: exists_during GO:0051321 ! meiotic cell cycle intersection_of: inheres_in CHEBI:36080 ! protein relationship: exists_during GO:0051321 ! meiotic cell cycle relationship: inheres_in CHEBI:36080 ! protein relationship: output_of FYPO:0001370 ! abnormal protein localization created_by: midori creation_date: 2015-02-19T16:16:17Z [Term] id: FYPO:0004449 name: decreased protein phosphorylation during mitotic metaphase def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal during metaphase of mitosis." [PomBase:mah] synonym: "decreased protein phosphorylation during metaphase of mitosis" EXACT [PomBase:mah] synonym: "decreased protein phosphorylation during mitotic metaphase during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein/peptide phosphorylation during mitotic metaphase" EXACT [PomBase:mah] synonym: "reduced protein phosphorylation during mitotic metaphase" EXACT [PomBase:mah] is_a: FYPO:0004357 ! decreased protein phosphorylation during mitosis intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0000089 ! mitotic metaphase intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0000089 ! mitotic metaphase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2015-02-24T10:42:13Z [Term] id: FYPO:0004450 name: normal protein phosphorylation during cellular response to calcium ion def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins is normal (i.e. indistinguishable from wild type) during a cellular response to calcium ions." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein phosphorylation during cellular response to calcium" EXACT [PomBase:mah] synonym: "normal protein phosphorylation during cellular response to calcium ion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein phosphorylation during cellular response to calcium ion during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000776 ! normal protein phosphorylation during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0071277 ! cellular response to calcium ion intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0071277 ! cellular response to calcium ion relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-02-24T10:49:31Z [Term] id: FYPO:0004451 name: decreased protein level during cellular response to calcium ion def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein measured in a cell during a cellular response to calcium ions is lower than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein accumulation during cellular response to calcium ion" RELATED [PomBase:mah] synonym: "decreased protein level during cellular response to calcium" EXACT [PomBase:mah] synonym: "decreased protein level during cellular response to calcium ion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein level during cellular response to calcium ion during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein level during cellular response to calcium ion" EXACT [PomBase:mah] is_a: FYPO:0001324 ! decreased protein level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0071277 ! cellular response to calcium ion intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0071277 ! cellular response to calcium ion relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2015-02-24T10:50:52Z [Term] id: FYPO:0004452 name: decreased transcription from CDRE promoter in response to calcium ion def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription from a calcineurin-dependent response element (CDRE)-containing promoter is decreased following a calcium ion stimulus." [PMID:25081204, PomBase:mah] synonym: "decreased transcription from CDRE promoter in response to calcium ion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased transcription from CDRE promoter in response to calcium ion during vegetative growth" EXACT [PomBase:mah] synonym: "reduced transcription from CDRE promoter in response to calcium ion" EXACT [PomBase:mah] is_a: FYPO:0000781 ! decreased transcription during vegetative growth created_by: midori creation_date: 2015-02-24T10:53:45Z [Term] id: FYPO:0004453 name: decreased protein localization to nucleus during cellular response to calcium ion def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleus is decreased during a cellular response to calcium ions." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to nucleus during cellular response to calcium ion" EXACT [PomBase:mah] synonym: "decreased protein localization to nucleus during cellular response to calcium ion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to nucleus during cellular response to calcium ion during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to nucleus during cellular response to calcium ion" EXACT [PomBase:mah] is_a: FYPO:0001514 ! decreased protein localization to nucleus during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0071277 ! cellular response to calcium ion intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034504 ! protein localization to nucleus relationship: happens_during GO:0071277 ! cellular response to calcium ion relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034504 ! protein localization to nucleus created_by: midori creation_date: 2015-02-24T11:46:02Z [Term] id: FYPO:0004454 name: resistance to calcium def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of calcium ions than normal." [PomBase:mah] synonym: "resistance to calcium during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to calcium during vegetative growth" EXACT [PomBase:mah] synonym: "resistance to calcium ion" EXACT [PomBase:mah] synonym: "resistant to calcium" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:29108 ! calcium(2+) relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:29108 ! calcium(2+) created_by: midori creation_date: 2015-02-24T11:47:45Z [Term] id: FYPO:0004455 name: decreased protein localization to nucleus def: "A cell phenotype in which the localization of a protein to the nucleus is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to nucleus" EXACT [PomBase:mah] synonym: "reduced protein localization to nucleus" EXACT [PomBase:mah] is_a: FYPO:0002956 ! abnormal protein localization to nucleus is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0034504 ! protein localization to nucleus relationship: inheres_in GO:0034504 ! protein localization to nucleus created_by: midori creation_date: 2015-02-24T12:07:32Z [Term] id: FYPO:0004456 name: increased protein localization to nucleus def: "A cell phenotype in which the localization of a protein to the nucleus is increased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to nucleus" EXACT [PomBase:mah] is_a: FYPO:0002956 ! abnormal protein localization to nucleus is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0034504 ! protein localization to nucleus relationship: inheres_in GO:0034504 ! protein localization to nucleus created_by: midori creation_date: 2015-02-24T12:07:58Z [Term] id: FYPO:0004457 name: decreased protein localization to nucleus during nitrogen starvation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleus is decreased when the cell is subject to nitrogen starvation." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to nucleus during nitrogen starvation" EXACT [PomBase:mah] synonym: "decreased protein localization to nucleus during nitrogen depletion" EXACT [PomBase:mah] synonym: "decreased protein localization to nucleus during nitrogen deprivation" EXACT [PomBase:mah] synonym: "reduced protein localization to nucleus during nitrogen starvation" EXACT [PomBase:mah] is_a: FYPO:0004455 ! decreased protein localization to nucleus intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in GO:0034504 ! protein localization to nucleus relationship: happens_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in GO:0034504 ! protein localization to nucleus created_by: midori creation_date: 2015-02-24T12:10:47Z [Term] id: FYPO:0004458 name: increased level of DNA replication gene RNA during nitrogen starvation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more DNA replication RNAs measured in a cell is higher than normal (i.e. higher than observed in wild-type cells) when the cell is subject to nitrogen starvation. DNA replication RNAs are transcribed from genes whose products are involved in DNA replication." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "increased DNA replication gene RNA accumulation during nitrogen starvation" RELATED [PomBase:mah] synonym: "increased level of DNA replication gene RNA during nitrogen depletion" EXACT [PomBase:mah] synonym: "increased level of DNA replication gene RNA during nitrogen deprivation" EXACT [PomBase:mah] synonym: "increased level of DNA replication gene transcripts nitrogen starvation" EXACT [PomBase:vw] is_a: FYPO:0002020 ! increased RNA level during nitrogen starvation created_by: midori creation_date: 2015-02-24T13:19:36Z [Term] id: FYPO:0004459 name: increased level of translation gene RNA during nitrogen starvation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more translation RNAs measured in a cell is higher than normal (i.e. higher than observed in wild-type cells) when the cell is subject to nitrogen starvation. Translation RNAs are transcribed from genes whose products are involved in translation." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "increased level of translation gene RNA during nitrogen depletion" EXACT [PomBase:mah] synonym: "increased level of translation gene RNA during nitrogen deprivation" EXACT [PomBase:mah] synonym: "increased level of translation gene transcripts nitrogen starvation" EXACT [PomBase:vw] synonym: "increased translation gene RNA accumulation during nitrogen starvation" RELATED [PomBase:mah] is_a: FYPO:0002020 ! increased RNA level during nitrogen starvation created_by: midori creation_date: 2015-02-24T13:34:12Z [Term] id: FYPO:0004460 name: decreased level of regulation of mitotic cell cycle gene RNA during nitrogen starvation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more regulation of mitotic cell cycle RNAs measured in a cell is lower than normal (i.e. lower than observed in wild-type cells) when the cell is subject to nitrogen starvation. Regulation of mitotic cell cycle RNAs are transcribed from genes whose products are involved in regulation of the mitotic cell cycle." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "decreased level of mitotic cell cycle regulation gene RNA during nitrogen starvation" EXACT [PomBase:mah] synonym: "decreased level of regulation of mitotic cell cycle gene RNA during nitrogen depletion" EXACT [PomBase:mah] synonym: "decreased level of regulation of mitotic cell cycle gene RNA during nitrogen deprivation" EXACT [PomBase:mah] synonym: "decreased level of regulation of mitotic cell cycle gene transcripts nitrogen starvation" EXACT [PomBase:vw] synonym: "decreased regulation of mitotic cell cycle gene RNA accumulation during nitrogen starvation" RELATED [PomBase:mah] synonym: "reduced level of regulation of mitotic cell cycle gene RNA during nitrogen starvation" EXACT [PomBase:mah] is_a: FYPO:0001152 ! decreased RNA level during nitrogen starvation created_by: midori creation_date: 2015-02-24T13:52:28Z [Term] id: FYPO:0004461 name: decreased level of regulation of sexual differentiation gene RNA during nitrogen starvation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more regulation of sexual differentiation RNAs measured in a cell is lower than normal (i.e. lower than observed in wild-type cells) when the cell is subject to nitrogen starvation. Sexual differentiation RNAs are transcribed from genes whose products are involved in sexual differentiation, i.e. mating and sporulation." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "decreased level of regulation of sexual differentiation gene RNA during nitrogen depletion" EXACT [PomBase:mah] synonym: "decreased level of regulation of sexual differentiation gene RNA during nitrogen deprivation" EXACT [PomBase:mah] synonym: "decreased level of regulation of sexual differentiation gene transcripts nitrogen starvation" EXACT [PomBase:vw] synonym: "decreased level of sexual differentiation regulation gene RNA during nitrogen starvation" EXACT [PomBase:mah] synonym: "decreased regulation of sexual differentiation gene RNA accumulation during nitrogen starvation" RELATED [PomBase:mah] synonym: "reduced level of regulation of sexual differentiation gene RNA during nitrogen starvation" EXACT [PomBase:mah] is_a: FYPO:0001152 ! decreased RNA level during nitrogen starvation created_by: midori creation_date: 2015-02-24T14:08:59Z [Term] id: FYPO:0004462 name: abolished protein localization to nucleus during nitrogen starvation def: "A cell phenotype in which the localization of a protein to the nucleus is abolished when the cell is subject to nitrogen starvation." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to nucleus during nitrogen starvation" EXACT [PomBase:mah] synonym: "abolished protein localization to nucleus during nitrogen depletion" EXACT [PomBase:mah] synonym: "abolished protein localization to nucleus during nitrogen deprivation" EXACT [PomBase:al] synonym: "protein localization to nucleus abolished during nitrogen starvation" EXACT [PomBase:mah] is_a: FYPO:0003450 ! abolished protein localization to nucleus intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0006995 ! cellular response to nitrogen starvation intersection_of: towards GO:0034504 ! protein localization to nucleus relationship: during GO:0006995 ! cellular response to nitrogen starvation relationship: towards GO:0034504 ! protein localization to nucleus created_by: midori creation_date: 2015-02-24T14:17:14Z [Term] id: FYPO:0004463 name: abolished protein localization to nucleus during glucose starvation def: "A cell phenotype in which the localization of a protein to the nucleus is abolished when the cell is subject to glucose starvation." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to nucleus during glucose starvation" EXACT [PomBase:mah] synonym: "abolished protein localization to nucleus during glucose depletion" EXACT [PomBase:mah] synonym: "abolished protein localization to nucleus during glucose deprivation" EXACT [PomBase:al] synonym: "protein localization to nucleus abolished during glucose starvation" EXACT [PomBase:mah] is_a: FYPO:0003450 ! abolished protein localization to nucleus intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0042149 ! cellular response to glucose starvation intersection_of: towards GO:0034504 ! protein localization to nucleus relationship: during GO:0042149 ! cellular response to glucose starvation relationship: towards GO:0034504 ! protein localization to nucleus created_by: midori creation_date: 2015-02-24T14:19:19Z [Term] id: FYPO:0004464 name: decreased protein phosphorylation during cellular response to camptothecin def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal during a cellular response to camptothecin." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein phosphorylation during cellular response to camptothecin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein phosphorylation during cellular response to camptothecin during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein phosphorylation during cellular response to CPT" EXACT [PomBase:mah] synonym: "reduced protein phosphorylation during cellular response to camptothecin" EXACT [PomBase:mah] is_a: FYPO:0001838 ! decreased protein phosphorylation during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: happens_during GO:0072757 ! cellular response to camptothecin intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: happens_during GO:0072757 ! cellular response to camptothecin relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2015-02-24T14:31:35Z [Term] id: FYPO:0004465 name: normal protein phosphorylation during cellular response to camptothecin def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins is normal (i.e. indistinguishable from wild type) during a cellular response to camptothecin." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein phosphorylation during cellular response to camptothecin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein phosphorylation during cellular response to camptothecin during vegetative growth" EXACT [PomBase:mah] synonym: "normal protein phosphorylation during cellular response to CPT" EXACT [PomBase:mah] is_a: FYPO:0000776 ! normal protein phosphorylation during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: happens_during GO:0072757 ! cellular response to camptothecin intersection_of: inheres_in GO:0006468 ! protein phosphorylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: happens_during GO:0072757 ! cellular response to camptothecin relationship: inheres_in GO:0006468 ! protein phosphorylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-02-24T14:32:51Z [Term] id: FYPO:0004466 name: increased number of Rad52 foci during cellular response to camptothecin def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the number of sites at which the protein Rad52 (also called Rad22) accumulates is greater than normal during a cellular response to camptothecin." [PMID:22064477, PomBase:mah] comment: Because Rad22 often accumulates at double-strand breaks, consider also annotating to 'accumulation of double-strand break sites' (FYPO:0000455). synonym: "increased number of Rad22 foci during cellular response to camptothecin" EXACT [PomBase:mah] synonym: "increased number of Rad52 foci during cellular response to camptothecin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased number of Rad52 foci during cellular response to camptothecin during vegetative growth" EXACT [PomBase:mah] synonym: "increased number of Rad52 foci during cellular response to CPT" EXACT [PomBase:mah] is_a: FYPO:0000972 ! increased number of Rad52 foci during vegetative growth created_by: midori creation_date: 2015-02-24T14:33:53Z [Term] id: FYPO:0004467 name: normal protein localization to cell tip during cellular response to salt stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the cell tip is normal (i.e. indistinguishable from wild type) during a cellular response to salt stress." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to cell tip during cellular response to salt stress" EXACT [PomBase:mah] synonym: "normal protein localization to cell tip during cellular response to salt stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to cell tip during cellular response to salt stress during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001587 ! normal protein localization to cell tip intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0071472 ! cellular response to salt stress intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990151 ! protein localization to cell tip intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0071472 ! cellular response to salt stress relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990151 ! protein localization to cell tip relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-02-24T15:38:17Z [Term] id: FYPO:0004468 name: decreased protein localization to cell tip during cellular response to salt stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the cell tip is decreased during a cellular response to salt stress." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to cell tip during cellular response to salt stress" EXACT [GO:0034504, PomBase:mah] synonym: "decreased protein localization to cell tip during cellular response to salt stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to cell tip during cellular response to salt stress during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to cell tip during cellular response to salt stress" EXACT [PomBase:mah] is_a: FYPO:0001586 ! decreased protein localization to cell tip intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0071472 ! cellular response to salt stress intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990151 ! protein localization to cell tip relationship: happens_during GO:0071472 ! cellular response to salt stress relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990151 ! protein localization to cell tip created_by: midori creation_date: 2015-02-24T15:41:04Z [Term] id: FYPO:0004469 name: normal phosphatase activity def: "A molecular function phenotype in which the observed rate of a phosphatase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0016791 ! phosphatase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0016791 ! phosphatase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-02-26T11:21:01Z [Term] id: FYPO:0004470 name: decreased protein localization to actomyosin contractile ring during mitotic anaphase def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the actomyosin contractile ring is decreased during anaphase of mitosis." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to actomyosin contractile ring during mitotic anaphase" EXACT [PomBase:mah] synonym: "decreased protein localization to actomyosin contractile ring during anaphase during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein localization to actomyosin contractile ring during anaphase of mitosis" EXACT [PomBase:mah] synonym: "decreased protein localization to actomyosin contractile ring involved in mitotic cytokinesis during mitotic anaphase" EXACT [GO:1904498] synonym: "decreased protein localization to cytokinetic contractile ring during mitotic anaphase" EXACT [PomBase:vw] synonym: "decreased protein localization to mitotic contractile ring during mitotic anaphase" EXACT [PomBase:vw] synonym: "reduced protein localization to actomyosin contractile ring during mitotic anaphase" EXACT [PomBase:mah] is_a: FYPO:0002699 ! decreased protein localization to actomyosin contractile ring intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0000090 ! mitotic anaphase intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1904498 ! protein localization to actomyosin contractile ring involved in mitotic cytokinesis relationship: happens_during GO:0000090 ! mitotic anaphase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1904498 ! protein localization to actomyosin contractile ring involved in mitotic cytokinesis created_by: midori creation_date: 2015-02-26T11:22:18Z [Term] id: FYPO:0004471 name: protein mislocalized to nucleolus during mitotic telophase def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a protein that is not normally found in the nucleolus is observed there during telophase of mitosis." [PomBase:mah] comment: Note that this term can be used to annotate any case where a protein is found in the nucleolus in a mutant, but not in wild type. In some cases, there may be enough additional information to annotate to 'abnormal protein localization' (FYPO:0000443) or one of its descendants. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "ectopic protein localization to nucleolus during mitotic telophase" EXACT [PomBase:vw] synonym: "protein mislocalised to nucleolus during mitotic telophase" EXACT [PomBase:mah] synonym: "protein mislocalised to nucleolus during telophase during vegetative growth" EXACT [PomBase:mah] synonym: "protein mislocalized to nucleolus during mitotic telophase during vegetative growth" EXACT [PomBase:mah] synonym: "protein mislocalized to nucleolus during telophase of mitosis" EXACT [PomBase:mah] is_a: FYPO:0000782 ! mislocalized protein during vegetative growth intersection_of: PATO:0000628 ! mislocalised intersection_of: exists_during GO:0000093 ! mitotic telophase intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CHEBI:36080 ! protein intersection_of: towards GO:0005730 ! nucleolus relationship: exists_during GO:0000093 ! mitotic telophase relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CHEBI:36080 ! protein relationship: towards GO:0005730 ! nucleolus created_by: midori creation_date: 2015-02-26T11:25:05Z [Term] id: FYPO:0004472 name: abolished protein localization to cytoplasm with protein mislocalized to nucleolus during cellular response to latrunculin B def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the cytoplasm is abolished, and the protein is instead present in the nucleolus, during a cellular response to latrunculin B." [PMID:18951025, PomBase:al, PomBase:mah] synonym: "abolished protein localisation to cytoplasm with protein mislocalised to nucleolus during cellular response to latrunculin B" RELATED [PomBase:mah] synonym: "abolished protein localization to cytoplasm with protein mislocalized to nucleolus during cellular response to latrunculin B during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to cytoplasm with protein mislocalized to nucleolus during cellular response to latrunculin B during vegetative growth" EXACT [PomBase:mah] synonym: "protein localization to cytoplasm abolished with protein mislocalized to nucleolus during cellular response to latrunculin B" EXACT [PomBase:mah] is_a: FYPO:0001179 ! protein localization abolished during vegetative growth created_by: midori creation_date: 2015-02-26T11:28:29Z [Term] id: FYPO:0004473 name: inviable after spore germination, without cell division, cell cycle arrest with unreplicated DNA def: "A phenotype in which a spore germinates to produce a cell that enters the cell cycle but then undergoes cell cycle arrest with unreplicated DNA, and eventually dies." [PMID:9356477, PomBase:mah] synonym: "essential; germinating spore, without cell division, cell cycle arrest with unreplicated DNA" RELATED [PomBase:mah] synonym: "inviable following spore germination, without cell division, cell cycle arrest with unreplicated DNA" EXACT [PomBase:mah] synonym: "inviable germinated spore, without cell division, cell cycle arrest with unreplicated DNA" EXACT [PomBase:mah] is_a: FYPO:0001924 ! inviable after spore germination, without cell division, cell cycle arrest intersection_of: FYPO:0000316 ! inviable after spore germination intersection_of: has_part FYPO:0001430 ! abnormal mitotic cell cycle arrest with unreplicated DNA relationship: has_part FYPO:0001430 ! abnormal mitotic cell cycle arrest with unreplicated DNA created_by: midori creation_date: 2015-02-26T11:41:02Z [Term] id: FYPO:0004474 name: normal mitotic cell cycle DNA replication checkpoint def: "A cell cycle checkpoint phenotype in which the mitotic cell cycle DNA replication checkpoint is normal (i.e. indistinguishable from wild type). The mitotic DNA replication checkpoint normally prevents the initiation of mitosis until DNA replication is complete." [PomBase:mah] synonym: "normal DNA replication checkpoint during mitotic cell cycle" EXACT [PomBase:mah] synonym: "normal DNA replication checkpoint during vegetative growth" EXACT [PomBase:mah] synonym: "normal mitotic DNA replication checkpoint activation" EXACT [PomBase:mah] is_a: FYPO:0001703 ! normal mitotic cell cycle checkpoint intersection_of: PATO:0000001 ! quality intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0033314 ! mitotic DNA replication checkpoint intersection_of: qualifier PATO:0000461 ! normal relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0033314 ! mitotic DNA replication checkpoint relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-02-26T11:44:01Z [Term] id: FYPO:0004475 name: decreased mitotic DNA replication initiation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the initiation of nuclear DNA replication is decreased. Initiation may be affected at one or more origins." [PMID:22970243, PomBase:mah] synonym: "decreased DNA replication initiation during mitotic cell cycle" EXACT [PomBase:mah] synonym: "decreased DNA replication initiation during vegetative growth" EXACT [PomBase:mah] synonym: "reduced mitotic DNA replication initiation" EXACT [PomBase:mah] is_a: FYPO:0001344 ! abnormal mitotic DNA replication initiation is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902975 ! mitotic DNA replication initiation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902975 ! mitotic DNA replication initiation created_by: midori creation_date: 2015-02-26T14:29:51Z [Term] id: FYPO:0004476 name: decreased protein phosphorylation during cellular response to calcium ion def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal during a cellular response to calcium ions." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein phosphorylation during cellular response to calcium" EXACT [PomBase:mah] synonym: "decreased protein phosphorylation during cellular response to calcium ion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein phosphorylation during cellular response to calcium ion during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein phosphorylation during cellular response to calcium ion" EXACT [PomBase:mah] is_a: FYPO:0001838 ! decreased protein phosphorylation during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0071277 ! cellular response to calcium ion intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0071277 ! cellular response to calcium ion relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2015-02-26T14:48:35Z [Term] id: FYPO:0004477 name: decreased RNA level during cellular response to calcium ion def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to calcium ions is lower than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased RNA accumulation during cellular response to calcium ion" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to calcium" EXACT [PomBase:mah] synonym: "decreased RNA level during cellular response to calcium ion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased RNA level during cellular response to calcium ion during vegetative growth" EXACT [PomBase:mah] synonym: "decreased transcript level during cellular response to calcium ion" EXACT [PomBase:vw] synonym: "reduced RNA level during cellular response to calcium ion" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0071277 ! cellular response to calcium ion intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0071277 ! cellular response to calcium ion relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2015-02-26T14:50:10Z [Term] id: FYPO:0004478 name: protein mislocalized to mitochondrion def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a protein that is not normally found in the mitochondrion is observed there." [PomBase:mah] comment: Note that this term can be used to annotate any case where a protein is found in the mitochondrion in a mutant, but not in wild type. In some cases, there may be enough additional information to annotate to 'abnormal protein localization' (FYPO:0000443) or one of its descendants. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "ectopic protein localization to mitochondrion" EXACT [PomBase:vw] synonym: "protein mislocalised to mitochondrion" EXACT [PomBase:mah] synonym: "protein mislocalised to mitochondrion during vegetative growth" EXACT [PomBase:mah] synonym: "protein mislocalized to mitochondrion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein mislocalized to mitochondrion during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000782 ! mislocalized protein during vegetative growth intersection_of: PATO:0000628 ! mislocalised intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CHEBI:36080 ! protein intersection_of: towards GO:0005739 ! mitochondrion relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CHEBI:36080 ! protein relationship: towards GO:0005739 ! mitochondrion created_by: midori creation_date: 2015-02-26T15:24:49Z [Term] id: FYPO:0004479 name: decreased transcription from CDRE promoter in response to salt stress def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription from a calcineurin-dependent response element (CDRE)-containing promoter is decreased during a cellular response to salt stress." [PMID:16928959, PomBase:mah] synonym: "decreased transcription from CDRE promoter during cellular response to salt stress" EXACT [PomBase:mah] synonym: "decreased transcription from CDRE promoter in response to salt stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased transcription from CDRE promoter in response to salt stress during vegetative growth" EXACT [PomBase:mah] synonym: "reduced transcription from CDRE promoter in response to salt stress" EXACT [PomBase:mah] is_a: FYPO:0000781 ! decreased transcription during vegetative growth created_by: midori creation_date: 2015-03-09T16:00:10Z [Term] id: FYPO:0004480 name: decreased transcription from CDRE promoter in response to micafungin def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription from a calcineurin-dependent response element (CDRE)-containing promoter is decreased during a cellular response to micafungin." [PMID:16928959, PomBase:mah] synonym: "decreased transcription from CDRE promoter during cellular response to micafungin" EXACT [PomBase:mah] synonym: "decreased transcription from CDRE promoter in response to micafungin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased transcription from CDRE promoter in response to micafungin during vegetative growth" EXACT [PomBase:mah] synonym: "reduced transcription from CDRE promoter in response to micafungin" EXACT [PomBase:mah] is_a: FYPO:0000781 ! decreased transcription during vegetative growth created_by: midori creation_date: 2015-03-09T16:01:31Z [Term] id: FYPO:0004481 name: abolished cell population growth at high temperature def: "A vegetative cell population growth phenotype in which a cell population does not grow at high temperatures." [PomBase:mah] comment: For fission yeast, high temperature usually corresponds to above 32 degrees Celsius. Use this term for a population of cells that does not grow at high temperature, but does grow at a lower temperature (a cell population that does not grow at any temperature would be considered inviable). Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "abolished growth at high temperature" BROAD [PomBase:mah] synonym: "abolished vegetative cell population growth at high temperature" EXACT [PomBase:mah] synonym: "cell population growth at high temperature abolished" EXACT [PomBase:mah] synonym: "heat sensitive" RELATED [PomBase:mah] synonym: "hypersensitive to high temperature" RELATED [PomBase:mah] synonym: "sensitive to heat" RELATED [PomBase:mah] synonym: "sensitive to high temperature" RELATED [PomBase:mah] synonym: "sensitive to high temperature during vegetative growth" RELATED [PomBase:mah] synonym: "temperature sensitive" RELATED [PomBase:mah] is_a: FYPO:0001575 ! abolished vegetative cell population growth created_by: midori creation_date: 2015-03-09T16:35:54Z [Term] id: FYPO:0004482 name: abnormal vacuole fusion def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which vacuole fusion, the merging of two vacuole membranes to form a single vacuole, is abnormal." [GO:0042144, PomBase:mah] synonym: "abnormal homotypic vacuole fusion" EXACT [GO:0042144] synonym: "abnormal vacuole fusion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal vacuole fusion during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal vacuole fusion, non-autophagic" EXACT [GO:0042144] is_a: FYPO:0000812 ! abnormal vacuole organization during vegetative growth is_a: FYPO:0001351 ! abnormal membrane organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0042144 ! vacuole fusion, non-autophagic intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0042144 ! vacuole fusion, non-autophagic relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-03-10T09:33:48Z [Term] id: FYPO:0004483 name: abnormal vacuole fusion during cellular hypotonic response def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which vacuole fusion is abnormal during a cellular response to a hypotonic environment." [PomBase:mah] synonym: "abnormal homotypic vacuole fusion during cellular hypotonic response" EXACT [GO:0042144] synonym: "abnormal vacuole fusion during cellular hypotonic response during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal vacuole fusion during cellular hypotonic response during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal vacuole fusion during hypotonic stress" EXACT [PomBase:al] synonym: "abnormal vacuole fusion, non-autophagic, during cellular hypotonic response" EXACT [GO:0042144] is_a: FYPO:0004482 ! abnormal vacuole fusion intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0071476 ! cellular hypotonic response intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0042144 ! vacuole fusion, non-autophagic intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0071476 ! cellular hypotonic response relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0042144 ! vacuole fusion, non-autophagic relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-03-10T09:33:54Z [Term] id: FYPO:0004484 name: abolished protein localization to prospore membrane def: "A cell phenotype in which the localization of a protein to the prospore membrane is abolished." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to prospore membrane" EXACT [PomBase:mah] synonym: "abolished protein localization to forespore membrane" EXACT [PomBase:mah] synonym: "protein localization to prospore membrane abolished" EXACT [PomBase:mah] is_a: FYPO:0000677 ! abnormal protein localization to prospore membrane is_a: FYPO:0001375 ! protein localization abolished intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:1902657 ! protein localization to prospore membrane relationship: towards GO:1902657 ! protein localization to prospore membrane created_by: midori creation_date: 2015-03-10T09:36:38Z [Term] id: FYPO:0004485 name: abnormal protein deacetylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the deacetylation of one or more specific proteins is abnormal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein deacetylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein deacetylation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000329 ! abnormal protein modification during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006476 ! protein deacetylation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006476 ! protein deacetylation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-03-10T09:55:57Z [Term] id: FYPO:0004486 name: abolished protein deacetylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the deacetylation of one or more specific proteins, or of specific protein sites, does not occur." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein deacetylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein deacetylation during vegetative growth" EXACT [PomBase:mah] synonym: "protein deacetylation abolished" EXACT [PomBase:mah] synonym: "protein deacetylation absent" EXACT [PomBase:al] is_a: FYPO:0000544 ! abolished protein modification during vegetative growth is_a: FYPO:0004485 ! abnormal protein deacetylation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0006476 ! protein deacetylation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0006476 ! protein deacetylation created_by: midori creation_date: 2015-03-10T09:56:05Z [Term] id: FYPO:0004487 name: increased protein acetylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the acetylation of one or more specific proteins, or of specific protein sites, occurs to a greater extent than normal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein acetylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein acetylation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000547 ! increased protein modification during vegetative growth is_a: FYPO:0002392 ! abnormal protein acetylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006473 ! protein acetylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006473 ! protein acetylation created_by: midori creation_date: 2015-03-10T09:56:30Z [Term] id: FYPO:0004488 name: abolished protein lysine methylation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the methylation of one or more lysine residues in specific proteins, or at specific protein sites, does not occur." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished peptidyl-lysine methylation" EXACT [GO:0018022] synonym: "abolished protein acetylation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein acetylation during vegetative growth" EXACT [PomBase:mah] synonym: "protein lysine methylation abolished" EXACT [PomBase:mah] synonym: "protein lysine methylation absent" EXACT [PomBase:al] is_a: FYPO:0000544 ! abolished protein modification during vegetative growth is_a: FYPO:0002392 ! abnormal protein acetylation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0018022 ! peptidyl-lysine methylation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0018022 ! peptidyl-lysine methylation created_by: midori creation_date: 2015-03-10T09:59:28Z [Term] id: FYPO:0004489 name: increased level of amino acid biosynthesis gene RNA during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more amino acid biosynthesis RNAs measured in a cell is higher than normal (i.e. higher than observed in wild-type cells). Amino acid biosynthesis RNAs are transcribed from genes whose products are involved in amino acid biosynthetic processes." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "increased amino acid biosynthesis gene RNA accumulation during vegetative growth" RELATED [PomBase:mah] synonym: "increased level of amino acid biosynthesis gene RNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased level of amino acid biosynthesis gene transcripts during vegetative growth" EXACT [PomBase:vw] is_a: FYPO:0000825 ! increased RNA level during vegetative growth created_by: midori creation_date: 2015-03-10T10:33:21Z [Term] id: FYPO:0004490 name: increased level of transport gene RNA during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more transport RNAs measured in a cell is higher than normal (i.e. higher than observed in wild-type cells). Transport RNAs are transcribed from genes whose products are involved in one or more transport processes." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "increased level of transport gene RNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased level of transport gene transcripts during vegetative growth" EXACT [PomBase:vw] synonym: "increased transport gene RNA accumulation during vegetative growth" RELATED [PomBase:mah] is_a: FYPO:0000825 ! increased RNA level during vegetative growth created_by: midori creation_date: 2015-03-10T10:35:08Z [Term] id: FYPO:0004491 name: decreased nucleosome occupancy def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which nucleosome occupancy is lower than normal at one or more specific sites. Nucleosome occupancy measures the tendency for DNA in a given region to be packaged into nucleosomes." [PMID:17446861, PomBase:mah] synonym: "reduced nucleosome occupancy" EXACT [PomBase:mah] is_a: FYPO:0000854 ! abnormal nucleosome positioning in euchromatin created_by: midori creation_date: 2015-03-10T10:36:57Z [Term] id: FYPO:0004492 name: abnormal RNA 5'-end processing def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which formation of the mature 5' end of an RNA molecule is abnormal." [GO:0000967, PomBase:mah] synonym: "abnormal RNA 5'-end processing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal RNA 5'-end processing during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001553 ! abnormal RNA processing intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0000967 ! rRNA 5'-end processing intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0000967 ! rRNA 5'-end processing relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-03-10T10:56:33Z [Term] id: FYPO:0004493 name: inviable after spore germination, single cell division, small cell def: "A phenotype in which a spore germinates to produce a cell that undergoes a single round of cell division to produce daughter cells that are smaller than normal, which then die." [PMID:8367300, PomBase:jh, PomBase:mah, PomBase:vw] synonym: "essential; germinating spore, single cell division, small cell" RELATED [PomBase:mah] synonym: "inviable following spore germination, single cell division, small cell" EXACT [PomBase:mah] synonym: "inviable germinated spore, single cell division, small cell" EXACT [PomBase:mah] is_a: FYPO:0002280 ! inviable after spore germination, single cell division created_by: midori creation_date: 2015-03-10T11:24:28Z [Term] id: FYPO:0004494 name: inviable branched, swollen, elongated vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is inviable, branched, septated, and has a larger volume and is longer, than normal. In a swollen cell, both length and diameter are greater than normal, although the cell is only considered elongated if the length:width ratio is also greater than normal." [PomBase:jh, PomBase:mah] synonym: "inviable branched, elongated, swollen vegetative cell" EXACT [PomBase:vw] synonym: "inviable branched, swollen, elongated cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable branched, swollen, elongated vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001490 ! inviable elongated vegetative cell is_a: FYPO:0001512 ! branched, elongated cell is_a: FYPO:0002251 ! inviable swollen elongated vegetative cell is_a: FYPO:0002415 ! inviable swollen vegetative cell with abnormal cell shape intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000015 ! branched vegetative cell intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000025 ! swollen cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000015 ! branched vegetative cell relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000025 ! swollen cell relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2015-03-11T16:01:12Z [Term] id: FYPO:0004495 name: inviable branched, swollen, elongated, multiseptate vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is inviable, branched, has more than one septum, and has a larger volume and is longer, than normal. In a swollen cell, both length and diameter are greater than normal, although the cell is only considered elongated if the length:width ratio is also greater than normal." [PomBase:jh, PomBase:mah] synonym: "inviable branched, elongated, swollen, multiseptate vegetative cell" EXACT [PomBase:vw] synonym: "inviable branched, swollen, elongated, multiseptate cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable branched, swollen, elongated, multiseptate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0004494 ! inviable branched, swollen, elongated vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000015 ! branched vegetative cell intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000025 ! swollen cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0004295 ! multiseptate cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000015 ! branched vegetative cell relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000025 ! swollen cell relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0004295 ! multiseptate cell created_by: midori creation_date: 2015-03-11T16:04:12Z [Term] id: FYPO:0004496 name: small multiseptate cell during stationary phase def: "A cell morphology phenotype in which a cell is smaller than normal and contains more than one septum, when the cell is in a culture in stationary phase." [PMID:8292390, PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: has_part FYPO:0000023 ! small cell intersection_of: has_part FYPO:0004297 ! multiseptate cell in stationary phase relationship: has_part FYPO:0000023 ! small cell relationship: has_part FYPO:0004297 ! multiseptate cell in stationary phase created_by: midori creation_date: 2015-03-11T16:31:01Z [Term] id: FYPO:0004497 name: small binucleate cell during stationary phase def: "A cell morphology phenotype in which a cell is smaller than normal and contains two nuclei, when the cell is in a culture in stationary phase." [PMID:8292390, PomBase:mah] is_a: FYPO:0000023 ! small cell is_a: FYPO:0003341 ! multinucleate created_by: midori creation_date: 2015-03-11T16:33:41Z [Term] id: FYPO:0004498 name: normal positive regulation of DNA-directed DNA polymerase activity def: "A regulation phenotype observed in the vegetative growth phase of the life cycle in which positive regulation of DNA-directed DNA polymerase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal positive regulation of DNA-directed DNA polymerase activity during mitotic cell cycle" EXACT [PomBase:mah] synonym: "normal positive regulation of DNA-directed DNA polymerase activity during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001319 ! normal cellular process during vegetative growth is_a: FYPO:0001334 ! regulation phenotype during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1900264 ! positive regulation of DNA-directed DNA polymerase activity intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1900264 ! positive regulation of DNA-directed DNA polymerase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-03-12T16:03:38Z [Term] id: FYPO:0004499 name: abnormal DNA polymerase processivity factor activity def: "A molecular function phenotype in which the rate or occurrence of DNA polymerase processivity factor activity is abnormal." [PomBase:mah] is_a: FYPO:0000707 ! abnormal molecular function is_a: FYPO:0001092 ! binding phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0030337 ! DNA polymerase processivity factor activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0030337 ! DNA polymerase processivity factor activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-03-12T16:06:53Z [Term] id: FYPO:0004500 name: decreased DNA polymerase processivity factor activity def: "A molecular function phenotype in which the rate or occurrence of DNA polymerase processivity factor activity is decreased." [PomBase:mah] synonym: "reduced DNA polymerase processivity factor activity" EXACT [PomBase:mah] is_a: FYPO:0004499 ! abnormal DNA polymerase processivity factor activity is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0030337 ! DNA polymerase processivity factor activity relationship: inheres_in GO:0030337 ! DNA polymerase processivity factor activity created_by: midori creation_date: 2015-03-12T16:06:58Z [Term] id: FYPO:0004501 name: normal DNA polymerase processivity factor activity def: "A molecular function phenotype in which the rate and occurrence of DNA polymerase processivity factor activity are normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000706 ! normal molecular function is_a: FYPO:0001092 ! binding phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0030337 ! DNA polymerase processivity factor activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0030337 ! DNA polymerase processivity factor activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-03-12T16:11:26Z [Term] id: FYPO:0004502 name: normal positive regulation of ATPase activity def: "A regulation phenotype observed in the vegetative growth phase of the life cycle in which positive regulation of an ATPase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal positive regulation of ATPase activity during mitotic cell cycle" EXACT [PomBase:mah] synonym: "normal positive regulation of ATPase activity during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001319 ! normal cellular process during vegetative growth is_a: FYPO:0001334 ! regulation phenotype during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0032781 ! positive regulation of ATPase activity intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0032781 ! positive regulation of ATPase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-03-12T16:12:30Z [Term] id: FYPO:0004503 name: increased cellular HMW ubiquitin conjugate level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein having high molecular mass due to polyubiquitin conjugation is greater than normal." [PMID:16149916, PMID:8247131, PomBase:mah] synonym: "accumulation of high molecular mass ubiquitin conjugates" EXACT [PomBase:vw] synonym: "accumulation of high molecular weight ubiquitin conjugates" EXACT [PomBase:vw] synonym: "accumulation of HMW ubiquitin conjugates" EXACT [PomBase:vw] synonym: "increased cellular high molecular mass ubiquitin conjugate level during vegetative growth" EXACT [PomBase:mah] synonym: "increased cellular high molecular weight ubiquitin conjugate level during vegetative growth" EXACT [PomBase:mah] synonym: "increased cellular HMW ubiquitin conjugate level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular HMW ubiquitin conjugate level during vegetative growth" EXACT [PomBase:mah] synonym: "increased HMW ubiquitin conjugate accumulation during cellular response to pheromone" RELATED [PomBase:mah] is_a: FYPO:0001327 ! increased protein level during vegetative growth created_by: midori creation_date: 2015-03-12T16:26:44Z [Term] id: FYPO:0004504 name: normal proteasome localization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which proteasome localization is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal proteasome localisation" EXACT [PomBase:mah] synonym: "normal proteasome localization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal proteasome localization during vegetative growth" EXACT [PomBase:mah] synonym: "normal proteasome location" RELATED [PomBase:mah] is_a: FYPO:0000644 ! normal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0031144 ! proteasome localization intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0031144 ! proteasome localization relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-03-16T11:53:35Z [Term] id: FYPO:0004505 name: abnormal nucleolar chromatin organization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which nucleolar chromatin organization is abnormal." [GO:1990700, PMID:18362178, PomBase:mah] synonym: "abnormal chromatin organization at nucleolus" RELATED [PomBase:mah] synonym: "abnormal nucleolar chromatin organization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal nucleolar chromatin organization during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001352 ! abnormal chromatin organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1990700 ! nucleolar chromatin organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1990700 ! nucleolar chromatin organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-03-16T13:48:33Z [Term] id: FYPO:0004506 name: abnormal nucleolar chromatin organization resulting in peripheral chromatin distribution def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which nucleolar chromatin organization is abnormal, such that nucleolar chromatin is distributed in a ring-shaped structure around the nuclear periphery rather than in a crescent-shaped structure on one side of the nucleus." [GO:1990700, PMID:18362178, PomBase:mah] synonym: "abnormal chromatin organization at nucleolus resulting in peripheral chromatin distribution" RELATED [PomBase:mah] synonym: "abnormal nucleolar chromatin organization resulting in peripheral chromatin distribution during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal nucleolar chromatin organization resulting in peripheral chromatin distribution during vegetative growth" EXACT [PomBase:mah] synonym: "nucleolar chromatin abnormally dispersed around nuclear periphery" RELATED [PomBase:vw] is_a: FYPO:0004505 ! abnormal nucleolar chromatin organization created_by: midori creation_date: 2015-03-16T13:58:17Z [Term] id: FYPO:0004507 name: abolished centromeric DNA separation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitotic sister chromatid separation does not occur at the centromeric regions. The remainder of the sister chromatids may or may not separate." [PMID:18362178, PomBase:mah] synonym: "abolished centromeric DNA separation during mitosis" EXACT [PomBase:mah] synonym: "abolished centromeric DNA separation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished centromeric DNA separation during vegetative growth" EXACT [PomBase:mah] synonym: "abolished DNA separation at centromere" EXACT [PomBase:mah] synonym: "abolished mitotic sister chromatid separation at centromere" EXACT [PomBase:mah] synonym: "abolished segregation of centromeric DNA" RELATED [PomBase:mah] synonym: "abolished sister kinetochore separation" RELATED [PomBase:vw] is_a: FYPO:0000670 ! abnormal mitotic sister chromatid separation created_by: midori creation_date: 2015-03-16T14:15:54Z [Term] id: FYPO:0004508 name: abolished rDNA separation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitotic sister chromatid separation does not occur at the rDNA repeat regions. The remainder of the sister chromatids may or may not separate." [PomBase:mah] synonym: "abolished mitotic sister chromatid separation at rDNA" EXACT [PomBase:mah] synonym: "abolished rDNA separation during mitosis" EXACT [PomBase:mah] synonym: "abolished rDNA separation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished rDNA separation during vegetative growth" EXACT [PomBase:mah] synonym: "abolished ribosomal DNA separation" EXACT [PomBase:mah] synonym: "abolished segregation of nucleolar rDNA" RELATED [PomBase:mah] is_a: FYPO:0000671 ! abnormal rDNA separation created_by: midori creation_date: 2015-03-16T14:23:50Z [Term] id: FYPO:0004509 name: mRNA absent from cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of messenger RNA (mRNA) measured in a cell is too low to detect. Total mRNA or a specific mRNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "messenger RNA absent from cell" EXACT [PomBase:mah] synonym: "mRNA absent from cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "mRNA absent from cell during vegetative growth" EXACT [PomBase:mah] synonym: "mRNA transcripts absent from cell" EXACT [PomBase:vw] synonym: "undetectable mRNA level" EXACT [PomBase:mah] is_a: FYPO:0002935 ! decreased mRNA level during vegetative growth is_a: FYPO:0003161 ! RNA absent from cell during vegetative growth intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards SO:0000234 ! mRNA relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000000 ! cell relationship: towards SO:0000234 ! mRNA created_by: midori creation_date: 2015-03-16T14:41:10Z [Term] id: FYPO:0004510 name: abnormal spindle assembly during meiosis II def: "A cellular process phenotype in which assembly of the meiotic spindle is abnormal during the second meiotic nuclear division." [PomBase:mah] synonym: "abnormal meiosis II spindle assembly" EXACT [PomBase:mah] synonym: "abnormal meiotic spindle assembly during meiosis II" EXACT [PomBase:mah] synonym: "abnormal spindle assembly at meiosis II" EXACT [PomBase:vw] synonym: "abnormal spindle assembly involved in meiosis II" EXACT [PomBase:mah] is_a: FYPO:0000737 ! abnormal meiotic spindle assembly intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0007135 ! meiosis II intersection_of: inheres_in_part_of GO:0090306 ! spindle assembly involved in meiosis intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0007135 ! meiosis II relationship: has_output FYPO:0000734 ! abnormal meiotic spindle relationship: inheres_in_part_of GO:0090306 ! spindle assembly involved in meiosis relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-03-16T14:52:17Z [Term] id: FYPO:0004511 name: long curved cytoplasmic microtubules def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells form cytoplasmic microtubules that are longer than normal and are curved, i.e. follow a smooth bend rather than a straight line." [PomBase:mah] comment: In severe instances of this phenotype, microtubules grow long enough to curve around the cell tip. synonym: "elongated curved cytoplasmic microtubules" EXACT [PomBase:mah] synonym: "long curved cytoplasmic microtubules during mitotic cell cycle" RELATED [PomBase:mah] synonym: "long curved cytoplasmic microtubules during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0004638 ! abnormal cellular physical quality phenotype intersection_of: FYPO:0004638 ! abnormal cellular physical quality phenotype intersection_of: has_part FYPO:0000233 ! long cytoplasmic microtubules intersection_of: has_part FYPO:0003327 ! curved cytoplasmic microtubules relationship: has_part FYPO:0000233 ! long cytoplasmic microtubules relationship: has_part FYPO:0003327 ! curved cytoplasmic microtubules created_by: midori creation_date: 2015-03-24T11:57:56Z [Term] id: FYPO:0004512 name: sensitive to EGTA def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to EGTA. Cells stop growing (and may die) at a concentration of EGTA that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to EGTA" EXACT [PomBase:mah] synonym: "sensitive to EGTA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to EGTA during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to ethylene glycol bis(2-aminoethyl)tetraacetic acid" EXACT [CHEBI:30740] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:30740 ! ethylene glycol bis(2-aminoethyl)tetraacetic acid relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:30740 ! ethylene glycol bis(2-aminoethyl)tetraacetic acid created_by: midori creation_date: 2015-03-24T12:13:26Z [Term] id: FYPO:0004513 name: resistance to latrunculin A def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of latrunculin A than normal." [PomBase:mah] synonym: "resistance to latrunculin A during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to latrunculin A during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to latrunculin A" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:69136 ! latrunculin A relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:69136 ! latrunculin A created_by: midori creation_date: 2015-03-24T12:15:08Z [Term] id: FYPO:0004514 name: viable elongated aseptate cell def: "A cell phenotype in which a cell has no septum, is elongated, and is viable." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'inviable cell population' (FYPO:0002059) or one of its descendants. synonym: "viable elongated aseptate cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "viable elongated aseptate cell during vegetative growth" EXACT [PomBase:mah] synonym: "viable long aseptate cell" EXACT [PomBase:vw] is_a: FYPO:0000950 ! elongated aseptate cell is_a: FYPO:0001492 ! viable elongated vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000949 ! aseptate intersection_of: has_part FYPO:0001491 ! viable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000949 ! aseptate relationship: has_part FYPO:0001491 ! viable vegetative cell created_by: midori creation_date: 2015-03-24T12:16:09Z [Term] id: FYPO:0004515 name: abnormal chromosome morphology, indistinct DNA def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which DNA is not visible in a distinct structure corresponding to the nucleus, but is instead diffuse or not visible at all." [PMID:25552606, PomBase:mah] is_a: FYPO:0000848 ! abnormal chromosome morphology created_by: midori creation_date: 2015-03-24T12:26:57Z [Term] id: FYPO:0004516 name: decreased number of Rad52 foci during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the number of sites at which the protein Rad52 (also called Rad22) accumulates is lower than normal." [PMID:22064477, PomBase:mah] synonym: "decreased number of Rad22 foci during vegetative growth" EXACT [PomBase:mah] synonym: "decreased number of Rad52 foci during mitotic cell cycle" RELATED [PomBase:mah] synonym: "reduced number of Rad52 foci during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001321 ! cellular physical quality phenotype during vegetative growth created_by: midori creation_date: 2015-03-24T12:28:30Z [Term] id: FYPO:0004517 name: viable vegetative cell enlarged around nucleus def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is viable and has a diameter larger than normal only near the middle of the cell, around the nucleus." [PMID:25552606, PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "viable cell enlarged around nucleus during vegetative growth" EXACT [PomBase:mah] synonym: "viable vegetative cell enlarged around nucleus during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0002197 ! viable vegetative cell with abnormal cell shape created_by: midori creation_date: 2015-03-24T12:30:06Z [Term] id: FYPO:0004518 name: inviable after spore germination, multiple cell divisions, branched, curved, elongated cell def: "A phenotype in which a spore germinates to produce a cell that is elongated and branched (and septated) and is curved along the long axis, and undergoes two or more rounds of cell division and then dies." [PomBase:al, PomBase:mah] synonym: "essential; germinating spore, multiple cell divisions, branched, curved, elongated cell" RELATED [PomBase:mah] synonym: "inviable after spore germination, multiple cell divisions, elongated, curved and branched cell" EXACT [PomBase:al] synonym: "inviable following spore germination, multiple cell divisions, branched, curved, elongated cell" EXACT [PomBase:mah] synonym: "inviable germinated spore, multiple cell divisions, branched, curved, elongated cell" EXACT [PomBase:mah] is_a: FYPO:0002170 ! inviable after spore germination, multiple cell divisions, branched, elongated cell created_by: midori creation_date: 2015-03-31T12:12:54Z [Term] id: FYPO:0004519 name: abnormal DNA-directed DNA polymerase activity def: "A molecular function phenotype in which the observed rate or other catalytic property of a DNA-directed DNA polymerase activity is abnormal." [PomBase:mah] synonym: "abnormal DNA polymerase activity" BROAD [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0003887 ! DNA-directed DNA polymerase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0003887 ! DNA-directed DNA polymerase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-03-31T12:23:55Z [Term] id: FYPO:0004520 name: decreased DNA-directed DNA polymerase processivity def: "A molecular function phenotype in which the observed processivity of a DNA-directed DNA polymerase activity is abnormal. Processivity refers to the number of nucleotides incorporated into a nascent DNA strand per polymerase-DNA binding event." [DOI:10.1038/npg.els.0001052, PomBase:mah] synonym: "decreased DNA polymerase processivity" BROAD [PomBase:mah] synonym: "reduced DNA-directed DNA polymerase processivity" EXACT [PomBase:mah] is_a: FYPO:0004519 ! abnormal DNA-directed DNA polymerase activity created_by: midori creation_date: 2015-03-31T12:26:08Z [Term] id: FYPO:0004521 name: inviable after spore germination, single or double cell division, branched, elongated cell def: "A phenotype in which a spore germinates to produce a cell that is elongated and branched (and septated), and undergoes one or two rounds of cell division and then dies." [PomBase:mah] synonym: "essential; germinating spore, single or double cell division, branched, elongated cell" RELATED [PomBase:mah] synonym: "inviable after spore germination, single or double cell division, elongated and branched cell" EXACT [PomBase:al] synonym: "inviable following spore germination, single or double cell division, branched, elongated cell" EXACT [PomBase:mah] synonym: "inviable germinated spore, single or double cell division, branched, elongated cell" EXACT [PomBase:mah] is_a: FYPO:0002724 ! inviable after spore germination, single or double cell division, elongated cell created_by: midori creation_date: 2015-03-31T13:05:06Z [Term] id: FYPO:0004522 name: inviable after spore germination, single or double cell division, branched, curved, elongated cell def: "A phenotype in which a spore germinates to produce a cell that is elongated and branched (and septated) and is curved along the long axis, and undergoes one or two rounds of cell division and then dies." [PomBase:mah] synonym: "essential; germinating spore, single or double cell division, branched, curved, elongated cell" RELATED [PomBase:mah] synonym: "inviable after spore germination, single or double cell division, elongated, curved and branched cell" EXACT [PomBase:al] synonym: "inviable following spore germination, single or double cell division, branched, curved, elongated cell" EXACT [PomBase:mah] synonym: "inviable germinated spore, single or double cell division, branched, curved, elongated cell" EXACT [PomBase:mah] is_a: FYPO:0004521 ! inviable after spore germination, single or double cell division, branched, elongated cell is_a: FYPO:0004523 ! inviable after spore germination, single or double cell division, curved, elongated cell created_by: midori creation_date: 2015-03-31T13:05:36Z [Term] id: FYPO:0004523 name: inviable after spore germination, single or double cell division, curved, elongated cell def: "A phenotype in which a spore germinates to produce a cell that is elongated and is curved along the long axis, and undergoes one or two rounds of cell division and then dies." [PomBase:mah] synonym: "essential; germinating spore, single or double cell division, curved, elongated cell" RELATED [PomBase:mah] synonym: "inviable after spore germination, single or double cell division, elongated and curved cell" EXACT [PomBase:al] synonym: "inviable following spore germination, single or double cell division, curved, elongated cell" EXACT [PomBase:mah] synonym: "inviable germinated spore, single or double cell division, curved, elongated cell" EXACT [PomBase:mah] is_a: FYPO:0002724 ! inviable after spore germination, single or double cell division, elongated cell created_by: midori creation_date: 2015-03-31T13:06:12Z [Term] id: FYPO:0004524 name: decreased number of Rad54 foci during cellular response to doxorubicin def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the number of sites at which the protein Rad54 (also called Rhp54) accumulates is lower than normal." [PMID:25701403, PomBase:mah] synonym: "decreased number of Rad54 foci during cellular response to doxorubicin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased number of Rad54 foci during cellular response to doxorubicin during vegetative growth" EXACT [PomBase:mah] synonym: "decreased number of Rhp54 foci during cellular response to doxorubicin" EXACT [PomBase:mah] synonym: "reduced number of Rad54 foci during cellular response to doxorubicin" EXACT [PomBase:mah] is_a: FYPO:0001321 ! cellular physical quality phenotype during vegetative growth created_by: midori creation_date: 2015-03-31T13:20:50Z [Term] id: FYPO:0004525 name: abnormal membrane organization during conjugation def: "A cellular process phenotype in which cellular membrane organization is abnormal during mating." [PomBase:mah] synonym: "abnormal cellular membrane organization during conjugation" EXACT [GO:0061024, PomBase:mah] synonym: "abnormal membrane organisation during conjugation" EXACT [PomBase:mah] synonym: "abnormal membrane organization during conjugation with cellular fusion" EXACT [GO:0000747] synonym: "abnormal membrane organization during mating" EXACT [PomBase:mah] is_a: FYPO:0001013 ! abnormal membrane organization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0000747 ! conjugation with cellular fusion intersection_of: inheres_in_part_of GO:0061024 ! membrane organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0000747 ! conjugation with cellular fusion relationship: inheres_in_part_of GO:0061024 ! membrane organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-03-31T13:30:32Z [Term] id: FYPO:0004526 name: abnormal regulation of transcription def: "A transcription regulation phenotype in which any process of regulation of transcription is abnormal." [PomBase:mah] synonym: "abnormal regulation of cellular transcription, DNA-dependent" EXACT [GO:0006355, PomBase:mah] synonym: "abnormal regulation of gene-specific transcription" RELATED [GO:006355, PomBase:mah] synonym: "abnormal regulation of transcription, DNA-dependent" EXACT [GO:0006355, PomBase:mah] is_a: FYPO:0000143 ! transcription regulation phenotype is_a: FYPO:0000628 ! abnormal cellular process intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0044838 ! cell quiescence intersection_of: inheres_in_part_of GO:0006355 ! regulation of transcription, DNA-templated intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0044838 ! cell quiescence relationship: inheres_in_part_of GO:0006355 ! regulation of transcription, DNA-templated relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-03-31T13:35:07Z [Term] id: FYPO:0004527 name: abnormal regulation of transcription during vegetative growth def: "A transcription regulation phenotype in which any process of regulation of transcription is abnormal in the vegetative growth phase of the life cycle." [PomBase:mah] synonym: "abnormal regulation of cellular transcription, DNA-dependent during vegetative growth" EXACT [GO:0006355, PomBase:mah] synonym: "abnormal regulation of gene-specific transcription during vegetative growth" RELATED [GO:006355, PomBase:mah] synonym: "abnormal regulation of transcription during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal regulation of transcription, DNA-dependent during vegetative growth" EXACT [GO:0006355, PomBase:mah] is_a: FYPO:0001335 ! transcription regulation phenotype during vegetative growth is_a: FYPO:0001362 ! abnormal cellular process during vegetative growth is_a: FYPO:0004526 ! abnormal regulation of transcription intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0044838 ! cell quiescence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0006355 ! regulation of transcription, DNA-templated intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0044838 ! cell quiescence relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0006355 ! regulation of transcription, DNA-templated relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-03-31T13:37:24Z [Term] id: FYPO:0004528 name: abnormal mitochondrial translation def: "A metabolism phenotype observed in the vegetative growth phase of the life cycle in which mitochondrial translation is abnormal." [PomBase:mah] comment: Note that this term should be used only when an experiment measures protein synthesis directly, e.g. by measuring incorporation of a radiolabeled amino acid. Consider annotating to 'altered protein level' (FYPO:0000834) or one of its descendants. synonym: "abnormal mitochondrial protein biosynthesis" EXACT [GO:0032543] synonym: "abnormal mitochondrial protein synthesis" EXACT [GO:0032543] synonym: "abnormal mitochondrial translation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal mitochondrial translation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000632 ! mitochondrial translation phenotype is_a: FYPO:0000809 ! abnormal mitochondrion organization is_a: FYPO:0001797 ! abnormal translation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0032543 ! mitochondrial translation intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0032543 ! mitochondrial translation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-03-31T13:41:31Z [Term] id: FYPO:0004529 name: normal mitochondrial translation def: "A metabolism phenotype observed in the vegetative growth phase of the life cycle in which mitochondrial translation is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: Note that this term should be used only when an experiment measures protein synthesis directly, e.g. by measuring incorporation of a radiolabeled amino acid. synonym: "normal mitochondrial protein biosynthesis" EXACT [GO:0032543] synonym: "normal mitochondrial protein synthesis" EXACT [GO:0032543] synonym: "normal mitochondrial translation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal mitochondrial translation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000859 ! normal metabolic process during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0032543 ! mitochondrial translation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0032543 ! mitochondrial translation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-03-31T13:46:55Z [Term] id: FYPO:0004530 name: abolished mitochondrial translation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitochondrial translation does not occur." [PomBase:mah] comment: Note that this term should be used only when an experiment measures mitochondrial protein synthesis directly, e.g. by measuring incorporation of a radiolabeled amino acid. Consider annotating to 'decreased protein level' (FYPO:0000835) or one of its descendants. synonym: "abolished mitochondrial protein biosynthesis" EXACT [GO:0032543] synonym: "abolished mitochondrial protein synthesis" EXACT [GO:0032543] synonym: "abolished mitochondrial translation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished mitochondrial translation during vegetative growth" EXACT [PomBase:mah] synonym: "mitochondrial translation abolished" EXACT [PomBase:mah] is_a: FYPO:0004528 ! abnormal mitochondrial translation is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0032543 ! mitochondrial translation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0032543 ! mitochondrial translation created_by: midori creation_date: 2015-03-31T13:47:36Z [Term] id: FYPO:0004531 name: inviable after spore germination, single or double cell division, small cell def: "A phenotype in which a spore germinates to produce a cell that is smaller than normal and undergoes one or two rounds of cell division." [PomBase:mah] synonym: "essential; germinating spore, single or double cell division, small cell" RELATED [PomBase:mah] synonym: "inviable following spore germination, single or double cell division, small cell" EXACT [PomBase:mah] synonym: "inviable germinated spore, single cell or double division, small cell" EXACT [PomBase:mah] is_a: FYPO:0001042 ! inviable after spore germination, single or double cell division created_by: midori creation_date: 2015-03-31T13:52:55Z [Term] id: FYPO:0004532 name: abnormal cell cycle arrest in mitotic metaphase with abnormal spindle def: "A cellular process phenotype in which progression through the mitotic cell cycle is arrested in metaphase under conditions where arrest does not normally occur, and the position or morphology of the mitotic spindle is abnormal." [PomBase:mah] comment: Metaphase is defined as the part of mitosis when chromosomes are aligned in the middle of the spindle. If no spindle is present, do not use this term, but consider 'abnormal cell cycle arrest in mitotic prophase' (FYPO:0003145). If you cannot tell whether a spindle is present, or if metaphase cannot be clearly detected, annotate to the more general term 'abnormal cell cycle arrest in mitotic M phase' (FYPO:0000608). synonym: "abnormal cell cycle arrest in mitotic metaphase with abnormal mitotic spindle" EXACT [PomBase:mah] synonym: "abnormal cell cycle arrest in mitotic metaphase with abnormal spindle during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal cell cycle arrest in mitotic metaphase with condensed chromosomes and abnormal spindle" EXACT [Pombase:vw] synonym: "abnormal mitotic cell cycle arrest in metaphase with abnormal spindle" EXACT [GO:0000089] is_a: FYPO:0000620 ! abnormal cell cycle arrest in mitotic metaphase intersection_of: FYPO:0001320 ! vegetative cell phenotype intersection_of: has_part FYPO:0000338 ! abnormal mitotic spindle intersection_of: has_part FYPO:0000620 ! abnormal cell cycle arrest in mitotic metaphase relationship: has_part FYPO:0000338 ! abnormal mitotic spindle relationship: has_part FYPO:0000620 ! abnormal cell cycle arrest in mitotic metaphase created_by: midori creation_date: 2015-03-31T14:23:17Z [Term] id: FYPO:0004533 name: normal cell wall beta-glucan level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of beta-D-glucan measured in the cell wall is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal cell wall beta-D-glucan level" EXACT [CHEBI:28793, PomBase:mah] synonym: "normal cell wall beta-glucan accumulation" RELATED [PomBase:mah] synonym: "normal cell wall beta-glucan level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal cell wall beta-glucan level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001078 ! normal beta-glucan level is_a: FYPO:0001313 ! normal subcellular component during vegetative growth intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0009277 ! fungal-type cell wall intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:28793 ! beta-D-glucan relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0009277 ! fungal-type cell wall relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:28793 ! beta-D-glucan created_by: midori creation_date: 2015-03-31T14:37:09Z [Term] id: FYPO:0004534 name: premature ascospore release from ascus def: "A cellular process phenotype in which the occurrence of ascospore release from an ascus begins earlier than normal." [GO:0071998, PMID:16751704, PomBase:mah] synonym: "accelerated ascospore release from ascus" RELATED [PomBase:al] synonym: "advanced ascospore release from ascus" EXACT [PomBase:mah] is_a: FYPO:0004272 ! abnormal ascospore release from ascus is_a: PATO:0000694 ! premature intersection_of: PATO:0000694 ! premature intersection_of: inheres_in GO:0071998 ! ascospore release from ascus relationship: inheres_in GO:0071998 ! ascospore release from ascus created_by: midori creation_date: 2015-03-31T14:39:36Z [Term] id: FYPO:0004535 name: inviable small spore with abnormal shape def: "A viability phenotype in which a spore is unable to survive under conditions in which wild type spores survive, and has a smaller volume than normal and an abnormal shape. An inviable spore does not germinate." [PomBase:mah] synonym: "inviable small abnormally shaped spore" EXACT [PomBase:mah] synonym: "inviable small spore with abnormal morphology" EXACT [PomBase:mah] synonym: "inviable spore with decreased size and abnormal shape" RELATED [PomBase:vw] synonym: "inviable spore with decreased spore size and abnormal shape" RELATED [PomBase:vw] synonym: "inviable spore with decreased spore volume and abnormal shape" EXACT [PomBase:mah] synonym: "inviable spore with decreased volume and abnormal shape" EXACT [PomBase:mah] synonym: "spore germination abolished, small misshapen spores" RELATED [PomBase:mah] synonym: "spore germination abolished, small spore with abnormal shape" RELATED [PomBase:mah] synonym: "spore germination abolished, spore with abnormal shape and decreased cell size" RELATED [PomBase:vw] synonym: "spore germination abolished, spore with abnormal shape and decreased cell volume" EXACT [PomBase:mah] is_a: FYPO:0000307 ! inviable small spore is_a: FYPO:0002427 ! inviable spore with abnormal shape intersection_of: FYPO:0000002 ! cell phenotype intersection_of: has_part FYPO:0000346 ! small spores intersection_of: has_part FYPO:0001126 ! abnormal cell shape intersection_of: has_part FYPO:0002151 ! inviable spore relationship: has_part FYPO:0000346 ! small spores relationship: has_part FYPO:0001126 ! abnormal cell shape relationship: has_part FYPO:0002151 ! inviable spore created_by: midori creation_date: 2015-04-02T13:48:30Z [Term] id: FYPO:0004536 name: abnormal response to mitotic cell cycle spindle assembly checkpoint signaling def: "A cellular process phenotype in which a mitotic cell cycle arrest that normally occurs in response to mitotic cell cycle spindle assembly checkpoint signaling is abnormal (does not occur, or occurs abnormally). Abnormal arrest may result from a problem with detection of conditions that normally trigger a checkpoint, transduction of the checkpoint signal, or the response to the checkpoint signal." [PomBase:mah] synonym: "abnormal mitotic cell cycle spindle assembly checkpoint arrest" RELATED [PomBase:mah] synonym: "abnormal occurrence of mitotic cell cycle arrest resulting from spindle assembly checkpoint activation" RELATED [PomBase:mah] synonym: "abnormal occurrence of mitotic cell cycle arrest resulting from spindle assembly defective checkpoint activation" RELATED [PomBase:vw] synonym: "abnormal response to mitotic spindle assembly checkpoint signaling" EXACT [PomBase:mah] is_a: FYPO:0002517 ! abnormal response to mitotic cell cycle checkpoint signaling intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0072476 ! response to mitotic spindle checkpoint signaling intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0072476 ! response to mitotic spindle checkpoint signaling relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-04-02T14:00:45Z [Term] id: FYPO:0004537 name: mitotic spindle assembly checkpoint override def: "A cellular process phenotype in which a mitotic cell cycle arrest that normally occurs in response to mitotic cell cycle spindle assembly checkpoint signaling does not occur. As a result, the septation initiation network (SIN) signaling pathway is activated despite activation of the mitotic spindle assembly checkpoint (SAC). Normally, under conditions that activate the SAC, SIN activation is inhibited and the cell cycle arrests in anaphase. In this phenotype, premature SIN activation leads to premature cytokinesis and the formation of cut cells." [PMID:11952833, PomBase:mah, PomBase:vw] synonym: "abolished response to mitotic cell cycle spindle assembly checkpoint signaling" EXACT [PomBase:mah] synonym: "mitotic cell cycle spindle assembly checkpoint override" EXACT [PomBase:mah] synonym: "mitotic SAC override" EXACT [PomBase:mah] synonym: "septation initiation signaling activation in presence of active mitotic spindle assembly checkpoint" EXACT [PomBase:mah] synonym: "SIN activation in presence of active mitotic SAC" EXACT [PomBase:mah] is_a: FYPO:0002518 ! abolished response to mitotic cell cycle checkpoint signaling is_a: FYPO:0004536 ! abnormal response to mitotic cell cycle spindle assembly checkpoint signaling intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0072476 ! response to mitotic spindle checkpoint signaling relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_output FYPO:0003165 ! cut relationship: has_output FYPO:0003250 ! premature septation relationship: towards GO:0072476 ! response to mitotic spindle checkpoint signaling created_by: midori creation_date: 2015-04-02T14:10:40Z [Term] id: FYPO:0004538 name: microtubules present in greater numbers def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells contain more microtubules than normal." [PomBase:mah] synonym: "increased level of MTs" EXACT [PomBase:mah] synonym: "microtubules present in increased numbers" EXACT [PomBase:mah] is_a: FYPO:0004315 ! abnormal microtubule cytoskeleton during vegetative growth is_a: PATO:0002002 ! has extra parts of type intersection_of: PATO:0002002 ! has extra parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0005874 ! microtubule relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0005874 ! microtubule created_by: midori creation_date: 2015-04-02T14:31:19Z [Term] id: FYPO:0004539 name: short cytoplasmic microtubules present in greater numbers def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell contains more, and shorter, cytoplasmic microtubules than normal." [PomBase:mah] synonym: "broken cytoplasmic microtubules" RELATED [PomBase:vw] synonym: "short cytoplasmic microtubules present in greater numbers during mitotic cell cycle" RELATED [PomBase:mah] synonym: "short cytoplasmic microtubules present in greater numbers during vegetative growth" EXACT [PomBase:mah] synonym: "short cytoplasmic microtubules present in increased numbers" EXACT [PomBase:mah] is_a: FYPO:0004638 ! abnormal cellular physical quality phenotype intersection_of: FYPO:0004638 ! abnormal cellular physical quality phenotype intersection_of: has_part FYPO:0002760 ! short cytoplasmic microtubules intersection_of: has_part FYPO:0004538 ! microtubules present in greater numbers relationship: has_part FYPO:0002760 ! short cytoplasmic microtubules relationship: has_part FYPO:0004538 ! microtubules present in greater numbers created_by: midori creation_date: 2015-04-02T14:32:10Z [Term] id: FYPO:0004540 name: increased chromatin silencing def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of chromatin silencing is increased." [PomBase:mah] synonym: "increased chromatin silencing during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased chromatin silencing during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000144 ! abnormal chromatin silencing is_a: FYPO:0000577 ! increased gene silencing intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006342 ! chromatin silencing relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006342 ! chromatin silencing created_by: midori creation_date: 2015-04-02T15:08:22Z [Term] id: FYPO:0004541 name: increased chromatin silencing at centromere inner repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of chromatin silencing at centromere inner repeat regions is increased." [PomBase:mah] synonym: "increased chromatin silencing at centromere imr" EXACT [PomBase:mah] synonym: "increased chromatin silencing at centromere inner repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased chromatin silencing at centromere inner repeat during vegetative growth" EXACT [PomBase:mah] synonym: "increased chromatin silencing at centromeric inner repeat region" EXACT [PomBase:mah] synonym: "increased heterochromatin silencing at centromere inner repeat" EXACT [PomBase:mah] is_a: FYPO:0004540 ! increased chromatin silencing intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0030702 ! chromatin silencing at centromere intersection_of: occurs_at SO:0001798 ! regional_centromere_inner_repeat_region relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0030702 ! chromatin silencing at centromere relationship: occurs_at SO:0001798 ! regional_centromere_inner_repeat_region created_by: midori creation_date: 2015-04-02T15:08:31Z [Term] id: FYPO:0004542 name: increased chromatin silencing at telomere def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of chromatin silencing at telomeric regions is increased." [PomBase:mah] synonym: "increased chromatin silencing at telomere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased chromatin silencing at telomere during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0004540 ! increased chromatin silencing intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006348 ! chromatin silencing at telomere relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006348 ! chromatin silencing at telomere created_by: midori creation_date: 2015-04-02T15:08:36Z [Term] id: FYPO:0004543 name: abnormal heterochromatin organization during vegetative growth def: "A cellular process phenotype in which any process of heterochromatin organization is abnormal in the vegetative growth phase of the life cycle. Heterochromatin organization results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin." [GO:0070828, PomBase:mah] synonym: "abnormal heterochromatin organisation during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal heterochromatin organization during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001352 ! abnormal chromatin organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0070828 ! heterochromatin organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0070828 ! heterochromatin organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-04-02T15:13:19Z [Term] id: FYPO:0004544 name: increased duration of heterochromatin maintenance def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the duration of heterochromatin maintenance is increased. Heterochromatin maintenance is the process that preserves heterochromatin in a stable functional or structural state." [GO:0070829, PomBase:mah] synonym: "increased duration of heterochromatin maintenance during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased duration of heterochromatin maintenance during vegetative growth" EXACT [PomBase:mah] synonym: "prolonged heterochromatin maintenance" EXACT [PomBase:mah] is_a: FYPO:0004543 ! abnormal heterochromatin organization during vegetative growth is_a: PATO:0000498 ! increased duration intersection_of: PATO:0000498 ! increased duration intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0070829 ! heterochromatin maintenance relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0070829 ! heterochromatin maintenance created_by: midori creation_date: 2015-04-02T15:14:36Z [Term] id: FYPO:0004545 name: decreased proteasomal ubiquitin-dependent protein degradation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of ubiquitin-dependent protein degradation via the N-end rule pathway is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased proteasomal ubiquitin-dependent protein breakdown" EXACT [GO:0043161] synonym: "decreased proteasomal ubiquitin-dependent protein catabolic process" EXACT [GO:0043161, PomBase:mah] synonym: "decreased proteasomal ubiquitin-dependent protein catabolism" EXACT [GO:0043161, PomBase:mah] synonym: "decreased proteasomal ubiquitin-dependent protein degradation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased proteasomal ubiquitin-dependent protein degradation during vegetative growth" EXACT [PomBase:mah] synonym: "decreased proteasome-mediated ubiquitin-dependent protein catabolic process" EXACT [GO:0043161] synonym: "reduced proteasomal ubiquitin-dependent protein degradation" EXACT [PomBase:mah] is_a: FYPO:0000846 ! decreased protein degradation during vegetative growth intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process created_by: midori creation_date: 2015-04-02T15:25:01Z [Term] id: FYPO:0004546 name: cut during cellular response to methyl methanesulfonate def: "A cut phenotype that is observed when a cell is exposed to methyl methanesulfonate. In a cut phenotype, a cell undergoes septation despite abnormal chromosome segregation, such that the septum physically divides the nucleus into two parts, and produces inviable daughter cells." [PomBase:mah] synonym: "cut during cellular response to methyl methanesulfonate during mitotic cell cycle" RELATED [PomBase:mah] synonym: "cut during cellular response to methyl methanesulfonate during vegetative growth" EXACT [PomBase:mah] synonym: "cut during cellular response to MMS" EXACT [PomBase:mah] is_a: FYPO:0003165 ! cut intersection_of: FYPO:0003165 ! cut intersection_of: during GO:0072703 ! cellular response to methyl methanesulfonate relationship: during GO:0072703 ! cellular response to methyl methanesulfonate created_by: midori creation_date: 2015-04-08T16:04:01Z [Term] id: FYPO:0004547 name: increased protein localization to mitochondrion def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the mitochondrion is increased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to mitochondrion" EXACT [PomBase:mah] synonym: "increased protein localization to mitochondrion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein localization to mitochondrion during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0004336 ! abnormal protein localization to mitochondrion is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0070585 ! protein localization to mitochondrion relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0070585 ! protein localization to mitochondrion created_by: midori creation_date: 2015-04-14T15:39:58Z [Term] id: FYPO:0004548 name: normal protein kinase activity during cellular response to hydroxyurea def: "A molecular function phenotype in which the observed rate of a protein kinase activity is normal (i.e. indistinguishable from wild type) during a cellular response to hydroxyurea." [PomBase:mah] synonym: "normal protein kinase activity in response to hydroxyurea" RELATED [PomBase:vw] is_a: FYPO:0003075 ! normal protein kinase activity intersection_of: PATO:0000001 ! quality intersection_of: during GO:0000084 ! mitotic S phase intersection_of: during GO:0072711 ! cellular response to hydroxyurea intersection_of: inheres_in GO:0004672 ! protein kinase activity intersection_of: qualifier PATO:0000461 ! normal relationship: during GO:0000084 ! mitotic S phase relationship: during GO:0072711 ! cellular response to hydroxyurea relationship: inheres_in GO:0004672 ! protein kinase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-04-14T15:48:01Z [Term] id: FYPO:0004549 name: normal S-phase DNA damage checkpoint during cellular response to UV def: "A cell cycle checkpoint phenotype in which the S-phase DNA damage checkpoint (also known as the intra-S phase DNA damage checkpoint) is normal (i.e. indistinguishable from wild type) when the cell is exposed to ultraviolet light. The S phase DNA damage checkpoint slows progression through S phase in response to DNA damage." [PomBase:mah] synonym: "normal intra-S phase DNA damage checkpoint during cellular response to UV" EXACT [GO:0031573] synonym: "normal S-phase DNA damage checkpoint activation during cellular response to UV" EXACT [PomBase:al] synonym: "normal S-phase DNA damage checkpoint during cellular response to ultraviolet light" EXACT [PomBase:mah] synonym: "normal S-phase DNA damage checkpoint during cellular response to UV during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal S-phase DNA damage checkpoint during cellular response to UV during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002102 ! normal DNA damage checkpoint during cellular response to UV is_a: FYPO:0003530 ! normal S-phase DNA damage checkpoint intersection_of: PATO:0000001 ! quality intersection_of: during GO:0034644 ! cellular response to UV intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0031573 ! intra-S DNA damage checkpoint intersection_of: qualifier PATO:0000461 ! normal relationship: during GO:0034644 ! cellular response to UV relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0031573 ! intra-S DNA damage checkpoint relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-04-14T15:50:36Z [Term] id: FYPO:0004550 name: abolished protein phosphorylation during cellular response to hydroxyurea def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, does not occur during a cellular response to hydroxyurea." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein phosphorylation during cellular response to hydroxyurea during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein phosphorylation during cellular response to hydroxyurea during vegetative growth" EXACT [PomBase:mah] synonym: "protein phosphorylation abolished during cellular response to hydroxyurea" EXACT [PomBase:mah] is_a: FYPO:0002033 ! abolished protein phosphorylation during vegetative growth intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: during GO:0072711 ! cellular response to hydroxyurea intersection_of: towards GO:0006468 ! protein phosphorylation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: during GO:0072711 ! cellular response to hydroxyurea relationship: towards GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2015-04-14T15:54:04Z [Term] id: FYPO:0004551 name: abnormal mitotic cell cycle regulation during cellular response to ionizing radiation during mitotic S phase def: "A cellular response phenotype observed in the vegetative growth phase of the life cycle in which the regulation of the mitotic cell cycle in response to ionizing radiation exposure during mitotic S phase is abnormal. Normally, cell cycle progression is slowed or arrested transiently following exposure to ionizing radiation. The most common abnormality is for the cell cycle to progress as in the absence of ionizing radiation." [PomBase:mah] synonym: "abnormal cell cycle regulation during cellular response to ionizing radiation during mitotic S phase" EXACT [PomBase:mah] synonym: "abnormal mitotic cell cycle delay following ionizing radiation during mitotic S phase" EXACT [PomBase:al] synonym: "abnormal mitotic cell cycle regulation during cellular response to IR during mitotic S phase" EXACT [PomBase:mah] synonym: "abnormal mitotic cell cycle regulation in response to ionizing radiation during mitotic S phase" EXACT [PomBase:mah] is_a: FYPO:0003489 ! abnormal mitotic cell cycle regulation during cellular response to ionizing radiation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0000084 ! mitotic S phase intersection_of: happens_during GO:0071479 ! cellular response to ionizing radiation intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0007346 ! regulation of mitotic cell cycle intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0000084 ! mitotic S phase relationship: happens_during GO:0071479 ! cellular response to ionizing radiation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0007346 ! regulation of mitotic cell cycle relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-04-14T15:54:49Z [Term] id: FYPO:0004552 name: normal cell cycle regulation during cellular response to ionizing radiation during mitotic G2 phase def: "A cellular response phenotype observed in the vegetative growth phase of the life cycle in which the regulation of the mitotic cell cycle in response to ionizing radiation exposure during mitotic G2 phase is normal (i.e. indistinguishable from wild type). Normally, cell cycle progression is slowed or arrested transiently following exposure to ionizing radiation." [PomBase:mah] synonym: "normal cell cycle delay following ionizing radiation during mitotic G2 phase" EXACT [PomBase:al] synonym: "normal cell cycle regulation during cellular response to ionizing radiation during mitotic G2 phase during vegetative growth" EXACT [PomBase:mah] synonym: "normal cell cycle regulation in response to ionizing radiation during mitotic G2 phase" EXACT [PomBase:mah] synonym: "normal mitotic cell cycle regulation during cellular response to ionizing radiation during G2 phase" EXACT [PomBase:mah] is_a: FYPO:0001927 ! normal cell cycle regulation during cellular response to ionizing radiation intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0000085 ! mitotic G2 phase intersection_of: happens_during GO:0071480 ! cellular response to gamma radiation intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0007346 ! regulation of mitotic cell cycle intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0000085 ! mitotic G2 phase relationship: happens_during GO:0071480 ! cellular response to gamma radiation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0007346 ! regulation of mitotic cell cycle relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-04-14T16:05:18Z [Term] id: FYPO:0004553 name: cut during cellular response to ionizing radiation during mitotic S phase def: "A cut phenotype that is observed when a cell is exposed to ionizing radiation during mitotic S phase. In a cut phenotype, a cell undergoes septation despite abnormal chromosome segregation, such that the septum physically divides the nucleus into two parts, and produces inviable daughter cells." [PomBase:mah] synonym: "cut during cellular response to ionizing radiation during mitotic S phase during vegetative growth" EXACT [PomBase:mah] synonym: "cut during cellular response to ionizing radiation during S phase of mitotic cell cycle" RELATED [PomBase:mah] synonym: "cut during cellular response to IR during mitotic S phase" EXACT [PomBase:mah] is_a: FYPO:0003487 ! cut during cellular response to ionizing radiation intersection_of: FYPO:0003165 ! cut intersection_of: during GO:0000084 ! mitotic S phase intersection_of: during GO:0071479 ! cellular response to ionizing radiation relationship: during GO:0000084 ! mitotic S phase relationship: during GO:0071479 ! cellular response to ionizing radiation created_by: midori creation_date: 2015-04-14T16:22:56Z [Term] id: FYPO:0004554 name: decreased protein phosphorylation during mitotic S phase during cellular response to ionizing radiation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of one or more specific proteins, or of specific protein sites, occurs to a lower extent than normal during S phase of the mitotic cell cycle and during a cellular response to ionizing radiation." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein phosphorylation during cellular response to ionizing radiation during mitotic S phase" EXACT [PomBase:mah] synonym: "decreased protein phosphorylation during cellular response to ionizing radiation during S phase of mitotic cell cycle" EXACT [PomBase:mah] synonym: "decreased protein phosphorylation during mitotic S phase during cellular response to ionizing radiation during vegetative growth" EXACT [PomBase:mah] synonym: "decreased protein phosphorylation during mitotic S phase during cellular response to IR" EXACT [PomBase:mah] synonym: "reduced protein phosphorylation during cellular response to IR during mitotic S phase" EXACT [PomBase:mah] synonym: "reduced protein phosphorylation during mitotic S phase during cellular response to ionizing radiation" EXACT [PomBase:mah] is_a: FYPO:0004261 ! decreased protein phosphorylation during mitotic G2 phase during cellular response to ionizing radiation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0000084 ! mitotic S phase intersection_of: happens_during GO:0071479 ! cellular response to ionizing radiation intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0000084 ! mitotic S phase relationship: happens_during GO:0071479 ! cellular response to ionizing radiation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2015-04-14T16:24:55Z [Term] id: FYPO:0004555 name: growth auxotrophic for choline def: "Auxotrophy in which a cell is unable to synthesize choline, and therefore requires choline in the medium for vegetative cell growth." [PomBase:mah] synonym: "choline auxotrophy" EXACT [PomBase:mah] synonym: "growth auxotrophic for choline during mitotic cell cycle" RELATED [PomBase:mah] synonym: "growth auxotrophic for choline during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000128 ! auxotrophy is_a: PATO:0000422 ! auxotrophic intersection_of: PATO:0000422 ! auxotrophic intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:15354 ! choline relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:15354 ! choline created_by: midori creation_date: 2015-04-14T16:35:19Z [Term] id: FYPO:0004556 name: decreased cellular phosphatidylcholine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of phosphatidylcholine measured in a cell is lower than normal." [PomBase:mah] synonym: "decreased cellular PC level" EXACT [PomBase:mah] synonym: "decreased cellular phosphatidylcholine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cellular phosphatidylcholine level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased phosphatidylcholine accumulation" RELATED [PomBase:al] synonym: "reduced cellular phosphatidylcholine level" EXACT [PomBase:mah] is_a: FYPO:0001329 ! decreased level of substance in cell during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:49183 ! phosphatidylcholine(1+) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:49183 ! phosphatidylcholine(1+) created_by: midori creation_date: 2015-04-14T16:41:55Z [Term] id: FYPO:0004557 name: increased vegetative cell population growth def: "A cell growth phenotype in which vegetative cell population growth is increased relative to normal. Increased growth may reflect a reduced growth rate (i.e. faster growth), growth that occurs to a greater extent than normal, or both." [PomBase:mah] synonym: "fast aerobic vegetative cell population growth" NARROW [PomBase:mah] synonym: "fast vegetative cell population growth" NARROW [PomBase:mah] synonym: "increased aerobic vegetative cell population growth" NARROW [PomBase:mah] is_a: FYPO:0003937 ! increased cell population growth created_by: midori creation_date: 2015-04-14T16:42:49Z [Term] id: FYPO:0004558 name: inviable after spore germination, without cell division, with abnormal cell morphology and abnormal actin cortical patch localization def: "A phenotype in which a spore germinates to produce an inviable cell that does not divide, has an abnormal morphology, and in which actin cortical patch localization is abnormal." [PMID:9765059, PomBase:mah] synonym: "essential; germinating spore, without cell division, with abnormal cell morphology and abnormal actin cortical patch localization" RELATED [PomBase:mah] synonym: "inviable after spore germination, undivided cell, with abnormal cell morphology and abnormal actin cortical patch localization" EXACT [PomBase:mah] synonym: "inviable after spore germination, without cell division, with abnormal cell morphology and abnormal actin cortical patch localisation" EXACT [PomBase:mah] synonym: "inviable after spore germination, without cell division, with abnormal cell morphology and abnormal actin cortical patch localization" EXACT [PomBase:mah] synonym: "inviable following spore germination, without cell division, with abnormal cell morphology and abnormal actin cortical patch localization" EXACT [PomBase:mah] synonym: "inviable germinated spore, without cell division, with abnormal cell morphology and abnormal actin cortical patch localization" EXACT [PomBase:mah] is_a: FYPO:0001991 ! inviable after spore germination, without cell division created_by: midori creation_date: 2015-04-14T16:49:44Z [Term] id: FYPO:0004559 name: viable swollen spheroid vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is viable, is shaped in the form of a spheroid, and has a larger volume than normal. In a swollen cell, both length and diameter are greater than normal, although the cell is only considered elongated if the length:width ratio is also greater than normal." [PomBase:mah] synonym: "viable enlarged spheroid vegetative cell" RELATED [PomBase:mah] synonym: "viable enlarged volume spheroid vegetative cell" EXACT [PomBase:mah] synonym: "viable large spheroid vegetative cell" RELATED [PomBase:vw] synonym: "viable swollen rounded vegetative cell" EXACT [PomBase:mah] synonym: "viable swollen spheroid cell during vegetative growth" EXACT [PomBase:mah] synonym: "viable swollen spheroid vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000945 ! swollen spheroid vegetative cell is_a: FYPO:0002380 ! viable spheroid vegetative cell is_a: FYPO:0002402 ! viable swollen vegetative cell with abnormal cell shape intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000021 ! spheroid vegetative cell intersection_of: has_part FYPO:0000025 ! swollen cell intersection_of: has_part FYPO:0001491 ! viable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000021 ! spheroid vegetative cell relationship: has_part FYPO:0000025 ! swollen cell relationship: has_part FYPO:0001491 ! viable vegetative cell created_by: midori creation_date: 2015-04-21T11:02:12Z [Term] id: FYPO:0004560 name: sensitive to BE49385A def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to BE49385A (a GPI synthesis inhibitor, also called YW3548). Cells stop growing (and may die) at a concentration of BE49385A that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to BE49385A" EXACT [PomBase:mah] synonym: "sensitive to BE49385A during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to BE49385A during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to YW3548" EXACT [CHEBI:79385, PMID:11297516] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:79385 ! YW3548 relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:79385 ! YW3548 created_by: midori creation_date: 2015-04-21T11:17:51Z [Term] id: FYPO:0004561 name: resistance to BE49385A def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of BE49385A (a GPI synthesis inhibitor, also called YW3548) than normal." [PomBase:mah] synonym: "resistance to BE49385A during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to BE49385A during vegetative growth" EXACT [PomBase:mah] synonym: "resistance to YW3548" EXACT [CHEBI:79385, PMID:11297516] synonym: "resistant to BE49385A" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:79385 ! YW3548 relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:79385 ! YW3548 created_by: midori creation_date: 2015-04-21T11:23:28Z [Term] id: FYPO:0004562 name: binucleate aseptate vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell has two nuclei and no septum." [PomBase:mah] synonym: "binucleate aseptate cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "binucleate aseptate cell during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000949 ! aseptate intersection_of: has_part FYPO:0001222 ! binucleate vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000949 ! aseptate relationship: has_part FYPO:0001222 ! binucleate vegetative cell created_by: midori creation_date: 2015-04-21T11:29:09Z [Term] id: FYPO:0004563 name: abnormal alpha-galactosidase activity def: "A molecular function phenotype in which the observed rate of alpha-galactosidase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004557 ! alpha-galactosidase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004557 ! alpha-galactosidase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-04-21T11:42:08Z [Term] id: FYPO:0004564 name: increased alpha-galactosidase activity def: "A molecular function phenotype in which the observed rate of alpha-galactosidase activity is increased." [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0004563 ! abnormal alpha-galactosidase activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0004557 ! alpha-galactosidase activity relationship: inheres_in GO:0004557 ! alpha-galactosidase activity created_by: midori creation_date: 2015-04-21T11:42:13Z [Term] id: FYPO:0004565 name: increased transcription of pheromone response gene RNA during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which transcription of pheromone response genes is increased. Pheromone response genes are normally transcribed in response to a pheromone stimulus." [PMID:15580593, PomBase:al, PomBase:mah] synonym: "increased transcription of pheromone response gene RNA during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000780 ! increased transcription during vegetative growth created_by: midori creation_date: 2015-04-21T11:54:28Z [Term] id: FYPO:0004566 name: sensitive to caffeine during meiosis II def: "A phenotype in which cells show increased sensitivity to caffeine during the second meiotic nuclear division. Cells stop growing (and may die) at a concentration of caffeine that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to caffeine during meiosis II" EXACT [PomBase:mah] synonym: "sensitive to caffeine during second meiotic nuclear division" EXACT [PomBase:mah] is_a: FYPO:0002683 ! increased sensitivity to chemical intersection_of: FYPO:0002683 ! increased sensitivity to chemical intersection_of: during GO:0007135 ! meiosis II intersection_of: towards CHEBI:27732 ! caffeine relationship: during GO:0007135 ! meiosis II relationship: towards CHEBI:27732 ! caffeine created_by: midori creation_date: 2015-04-21T12:19:16Z [Term] id: FYPO:0004567 name: fragmented spindle during meiosis II def: "A cell phenotype which the spindle is broken into fragments during the second meiotic nuclear division." [PomBase:mah] synonym: "fragmented meiotic spindle during meiosis II" EXACT [PomBase:mah] synonym: "fragmented spindle during second meiotic nuclear division" EXACT [PomBase:mah] synonym: "fragmented spindle pole body during mitotic cell cycle" RELATED [PomBase:mah] synonym: "spindle fragmentation during meiosis II" EXACT [PomBase:vw] is_a: FYPO:0000734 ! abnormal meiotic spindle is_a: FYPO:0003607 ! abnormal spindle morphology is_a: PATO:0001444 ! broken intersection_of: PATO:0001444 ! broken intersection_of: exists_during GO:0007135 ! meiosis II intersection_of: inheres_in GO:0072687 ! meiotic spindle relationship: exists_during GO:0007135 ! meiosis II relationship: inheres_in GO:0072687 ! meiotic spindle created_by: midori creation_date: 2015-04-21T12:45:06Z [Term] id: FYPO:0004568 name: normal spindle def: "A physical cellular phenotype in which the presence, distribution, or morphology of the mitotic or meiotic spindle is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0001233 ! normal subcellular component intersection_of: PATO:0001241 ! physical object quality intersection_of: inheres_in GO:0005819 ! spindle intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0005819 ! spindle relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-04-21T12:59:45Z [Term] id: FYPO:0004569 name: normal spindle during meiosis I def: "A physical cellular phenotype in which the presence, distribution, or morphology of the meiotic spindle is normal (i.e. indistinguishable from wild type) during the first meiotic nuclear division." [PomBase:mah] synonym: "normal meiosis I spindle" EXACT [PomBase:al] synonym: "normal meiotic spindle during meiosis I" EXACT [PomBase:mah] synonym: "normal spindle during first meiotic nuclear division" RELATED [PomBase:mah] is_a: FYPO:0004568 ! normal spindle intersection_of: PATO:0001241 ! physical object quality intersection_of: exists_during GO:0007127 ! meiosis I intersection_of: inheres_in GO:0072687 ! meiotic spindle intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0007127 ! meiosis I relationship: inheres_in GO:0072687 ! meiotic spindle relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-04-21T13:01:43Z [Term] id: FYPO:0004570 name: decreased meiotic sister chromatid separation def: "A cellular process phenotype in which the occurrence of meiotic sister chromatid separation is decreased." [PomBase:mah] synonym: "decreased chromosome separation during meiosis II" EXACT [PomBase:al] synonym: "reduced meiotic sister chromatid separation" EXACT [PomBase:mah] is_a: FYPO:0000151 ! abnormal meiotic chromosome segregation is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0051757 ! meiotic sister chromatid separation relationship: inheres_in GO:0051757 ! meiotic sister chromatid separation created_by: midori creation_date: 2015-04-21T13:22:43Z [Term] id: FYPO:0004571 name: increased RNA level during cellular response to hydrogen peroxide def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to hydrogen peroxide is higher than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased mRNA level during cellular response to hydrogen peroxide" NARROW [PomBase:mah] synonym: "increased RNA accumulation during cellular response to hydrogen peroxide" RELATED [PomBase:mah] synonym: "increased RNA level during cellular response to H2O2" EXACT [PomBase:mah] synonym: "increased RNA level during cellular response to hydrogen peroxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased RNA level during cellular response to hydrogen peroxide during vegetative growth" EXACT [PomBase:mah] synonym: "increased transcript level during cellular response to hydrogen peroxide" EXACT [PomBase:vw] is_a: FYPO:0001279 ! increased RNA level during cellular response to oxidative stress intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0070301 ! cellular response to hydrogen peroxide intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0070301 ! cellular response to hydrogen peroxide relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2015-04-21T13:36:54Z [Term] id: FYPO:0004572 name: decreased exocytosis def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which exocytosis occurs to a lower extent than normal. Exocytosis is the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. A phenotype may affect exocytosis of all cargoes, or of specific cargo such as a particular protein." [GO:0006887, PomBase:mah] synonym: "decreased exocytosis during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased exocytosis during vegetative growth" EXACT [PomBase:mah] synonym: "reduced exocytosis" EXACT [PomBase:mah] is_a: FYPO:0002089 ! abnormal exocytosis is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006887 ! exocytosis relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006887 ! exocytosis created_by: midori creation_date: 2015-04-21T13:38:15Z [Term] id: FYPO:0004573 name: increased telomeric transcript level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of non-coding RNA transcribed from telomeric regions measured in a cell is higher than normal." [PMID:25398909, PomBase:mah, SO:0001927] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased telomeric lncRNA level" EXACT [PomBase:al] synonym: "increased telomeric transcript accumulation" RELATED [PomBase:mah] synonym: "increased telomeric transcript level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased telomeric transcript level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000825 ! increased RNA level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards SO:0001927 ! telomeric_transcript relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards SO:0001927 ! telomeric_transcript created_by: midori creation_date: 2015-04-21T13:59:10Z [Term] id: FYPO:0004574 name: increased subtelomere-derived RNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of any RNA transcribed from sub-telomeric regions measured in a cell is higher than normal." [PMID:25398909, PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "accumulation of subtelomere-derived RNA transcripts" RELATED [PomBase:vw] synonym: "increased subtelomere-derived RNA accumulation" RELATED [PomBase:mah] synonym: "increased subtelomere-derived RNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased subtelomere-derived RNA level during vegetative growth" EXACT [PomBase:mah] synonym: "increased subtelomere-derived RNA transcript level" EXACT [PomBase:vw] is_a: FYPO:0000825 ! increased RNA level during vegetative growth created_by: midori creation_date: 2015-04-21T14:11:01Z [Term] id: FYPO:0004575 name: increased histone H3-K9 acetylation at subtelomere def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which acetylation of lysine at position 9 of histone H3 in subtelomeric regions occurs to a greater extent than normal." [PMID:25398909, PomBase:mah] synonym: "increased histone H3-K9 acetylation at subtelomere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H3-K9 acetylation at subtelomere during vegetative growth" EXACT [PomBase:mah] synonym: "increased histone H3-K9 acetylation at subtelomeric region" EXACT [PomBase:vw] synonym: "increased histone H3K9 acetylation at subtelomere" EXACT [GO:0043970, PomBase:mah] synonym: "increased subtelomeric histone H3K9 acetylation" EXACT [GO:0043970, PomBase:mah] is_a: FYPO:0000892 ! increased histone H3-K9 acetylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0043970 ! histone H3-K9 acetylation intersection_of: occurs_at SO:0001997 ! subtelomere relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0043970 ! histone H3-K9 acetylation relationship: occurs_at SO:0001997 ! subtelomere created_by: midori creation_date: 2015-04-21T14:13:15Z [Term] id: FYPO:0004576 name: decreased histone H3-K9 acetylation at subtelomere def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which acetylation of lysine at position 9 of histone H3 in subtelomeric regions occurs to a lower extent than normal." [PMID:25398909, PomBase:mah] synonym: "decreased histone H3-K9 acetylation at subtelomere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H3-K9 acetylation at subtelomere during vegetative growth" EXACT [PomBase:mah] synonym: "decreased histone H3-K9 acetylation at subtelomeric region" EXACT [PomBase:vw] synonym: "decreased histone H3K9 acetylation at subtelomere" EXACT [GO:0043970, PomBase:mah] synonym: "decreased subtelomeric histone H3K9 acetylation" EXACT [GO:0043970, PomBase:mah] synonym: "reduced histone H3-K9 acetylation at subtelomere" EXACT [PomBase:mah] is_a: FYPO:0001442 ! decreased histone H3-K9 acetylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0043970 ! histone H3-K9 acetylation intersection_of: occurs_at SO:0001997 ! subtelomere relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0043970 ! histone H3-K9 acetylation relationship: occurs_at SO:0001997 ! subtelomere created_by: midori creation_date: 2015-04-21T14:14:18Z [Term] id: FYPO:0004577 name: decreased histone H3-K9 trimethylation at subtelomere def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which trimethylation of lysine at position 9 of histone H3 in subtelomeric regions occurs to a lower extent than normal." [PMID:25398909, PomBase:mah] synonym: "decreased histone H3-K9 trimethylation at subtelomere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone H3-K9 trimethylation at subtelomere during vegetative growth" EXACT [PomBase:mah] synonym: "decreased histone H3-K9 trimethylation at subtelomeric region" EXACT [PomBase:vw] synonym: "decreased histone H3K9 trimethylation at subtelomere" EXACT [GO:0036124, PomBase:mah] synonym: "decreased subtelomeric histone H3K9 trimethylation" EXACT [GO:0036124, PomBase:mah] synonym: "reduced histone H3-K9 trimethylation at subtelomere" EXACT [PomBase:mah] is_a: FYPO:0000882 ! decreased histone H3-K9 trimethylation intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0036124 ! histone H3-K9 trimethylation intersection_of: occurs_at SO:0001997 ! subtelomere relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0036124 ! histone H3-K9 trimethylation relationship: occurs_at SO:0001997 ! subtelomere created_by: midori creation_date: 2015-04-21T14:15:38Z [Term] id: FYPO:0004578 name: decreased level of histone H3 in cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of histone H3 measured in the cell is lower than normal." [PomBase:mah] synonym: "decreased accumulation of histone H3 in cell" RELATED [PomBase:mah] synonym: "decreased cellular histone H3 level" EXACT [PomBase:mah] synonym: "decreased histone H3 level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased level of histone H3 in cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased level of histone H3 in cell during vegetative growth" EXACT [PomBase:mah] synonym: "reduced level of histone H3 in cell" EXACT [PomBase:mah] is_a: FYPO:0001324 ! decreased protein level during vegetative growth intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards PR:000027594 relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards PR:000027594 created_by: midori creation_date: 2015-04-21T14:20:31Z [Term] id: FYPO:0004579 name: normal transposable element-derived small RNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of small RNA (such as siRNA) derived from transposable element transcripts measured in a cell normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal transposable element-derived small RNA accumulation" RELATED [PomBase:mah] synonym: "normal transposable element-derived small RNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal transposable element-derived small RNA level during vegetative growth" EXACT [PomBase:mah] synonym: "normal transposable element-derived small RNA transcript level" EXACT [PomBase:vw] is_a: FYPO:0001317 ! normal RNA level during vegetative growth created_by: midori creation_date: 2015-04-21T14:23:38Z [Term] id: FYPO:0004580 name: increased number of plasmid catenanes def: "A cell phenotype in which a cell contains a larger number plasmid catenanes than normal. Plasmid catenanes are structures formed by two or more copies of a circular plasmid DNA molecule catenated together." [PMID:15957215, PomBase:mah] synonym: "increased number of catenated plasmids" EXACT [PomBase:mah] synonym: "increased number of plasmid catenanes during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased number of plasmid catenanes during vegetative growth" EXACT [PomBase:mah] synonym: "increased plasmid catenane level" EXACT [PomBase:mah] is_a: FYPO:0003755 ! abnormal vegetative cell phenotype created_by: midori creation_date: 2015-04-21T15:00:53Z [Term] id: FYPO:0004581 name: increased transcriptional response to pheromone def: "A transcription regulation phenotype in which pheromone-responsive positive regulation of transcription from an RNA polymerase II promoter is increased." [GO:0007329, PomBase:mah] synonym: "increased positive regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [GO:0007329] is_a: FYPO:0000623 ! abnormal positive regulation of transcription is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0007329 ! positive regulation of transcription from RNA polymerase II promoter by pheromones relationship: inheres_in GO:0007329 ! positive regulation of transcription from RNA polymerase II promoter by pheromones created_by: midori creation_date: 2015-04-21T15:25:40Z [Term] id: FYPO:0004582 name: increased cell cycle arrest in mitotic G1 phase in response to nitrogen starvation def: "A cellular process phenotype in which cell cycle arrest in response to nitrogen starvation occurs in G1 phase, but its occurrence is increased." [PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "increased cell cycle arrest in mitotic G1 phase during cellular response to nitrogen starvation" EXACT [PomBase:mah] synonym: "increased cell cycle arrest in mitotic G1 phase in response to nitrogen depletion" EXACT [PomBase:vw] synonym: "increased cell cycle arrest in mitotic G1 phase in response to nitrogen deprivation" EXACT [PomBase:vw] synonym: "increased mitotic cell cycle arrest in G1 phase in response to nitrogen starvation" EXACT [PomBase:mah] synonym: "increased mitotic G1 arrest in response to nitrogen starvation" EXACT [PomBase:mah] synonym: "increased nitrogen deprivation-induced G1 arrest" EXACT [PomBase:vw] is_a: FYPO:0000445 ! cell cycle arrest in mitotic G1 phase is_a: FYPO:0000710 ! abnormal mitotic cell cycle arrest in response to nitrogen starvation is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0030996 ! mitotic cell cycle arrest in response to nitrogen starvation relationship: inheres_in GO:0030996 ! mitotic cell cycle arrest in response to nitrogen starvation created_by: midori creation_date: 2015-04-21T15:28:40Z [Term] id: FYPO:0004583 name: abnormal meiotic chromosome condensation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which meiotic chromosome condensation is abnormal." [PMID:23263988, PomBase:mah] synonym: "abnormal chromosome condensation during meiosis I" EXACT [PMID:23263988, PomBase:mah] synonym: "abnormal chromosome condensation during meiotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000159 ! abnormal chromosome condensation is_a: FYPO:0002739 ! abnormal meiotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0010032 ! meiotic chromosome condensation intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0010032 ! meiotic chromosome condensation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-04-29T11:04:41Z [Term] id: FYPO:0004584 name: abnormally arrested meiosis I with four spindle pole bodies def: "A cellular process phenotype in which the first meiotic nuclear division is arrested under conditions where arrest does not normally occur, and in which arrested cells contain four spindle pole bodies. Cells may contain one or two spindles, but the nucleus does not divide." [PMID:9763441, PomBase:mah] synonym: "abnormally arrested meiosis I with duplicated spindle pole bodies" EXACT [PomBase:al] synonym: "abnormally arrested meiosis I with four SPBs" EXACT [PomBase:mah] synonym: "cell cycle arrest in meiosis I with four spindle pole bodies" EXACT [PomBase:mah] is_a: FYPO:0002817 ! abnormally arrested meiosis I relationship: has_part FYPO:0004609 ! spindle pole bodies present in greater numbers during meiosis created_by: midori creation_date: 2015-04-29T11:15:56Z [Term] id: FYPO:0004585 name: abnormal linear element morphology def: "A physical cellular phenotype in which the size, shape, or structure of linear elements is abnormal." [PomBase:mah] is_a: FYPO:0000287 ! abnormal subcellular component is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: inheres_in GO:0030998 ! linear element intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0030998 ! linear element relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-04-29T11:21:08Z [Term] id: FYPO:0004586 name: sensitive to caffeine and hydroxyurea def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to a combination of caffeine and rapamycin. Cells stop growing (and may die) at concentrations of caffeine and rapamycin that allows wild type cells to grow." [PMID:10757807, PomBase:mah] synonym: "hypersensitive to caffeine and hydroxyurea" EXACT [PomBase:mah] synonym: "sensitive to caffeine and HU" EXACT [PomBase:mah] synonym: "sensitive to caffeine and hydroxyurea during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to caffeine and hydroxyurea during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth created_by: midori creation_date: 2015-04-29T11:46:35Z [Term] id: FYPO:0004587 name: abolished cell population growth on urea nitrogen source def: "A vegetative cell population growth phenotype in which a cell population does not grow in a medium containing urea as the nitrogen source." [PomBase:mah] comment: Use this term for a population of cells that does not grow with urea as the nitrogen source, but does grow using a different nitrogen source (a cell population that does not grow on any media would be considered inviable). Note that cell growth terms refer to growth under aerobic conditions unless stated otherwise. synonym: "abolished urea utilization" RELATED [PomBase:mah, PomBase:vw] synonym: "abolished vegetative cell population growth on urea nitrogen source" EXACT [PomBase:mah] synonym: "cell population growth on urea nitrogen source abolished" EXACT [PomBase:mah] is_a: FYPO:0001575 ! abolished vegetative cell population growth created_by: midori creation_date: 2015-04-29T11:59:27Z [Term] id: FYPO:0004588 name: abnormal mitosis following normal mitosis def: "A cellular process phenotype in which mitosis takes place abnormally after the cell has undergone a normal mitotic nuclear division and passed through the subsequent mitotic interphase." [PomBase:mah] comment: This phenotype affects the second round of mitosis to take place after a mutation exerts its effect. For example, if a conditional mutant is shifted to restrictive conditions in G1 or S phase and the first mitosis thereafter is normal, but the second is not (even if cells are returned to permissive conditions in the second G1 or S phase), this term is applicable. synonym: "abnormal mitosis following normal mitosis and interphase" EXACT [PomBase:mah] synonym: "abnormal mitosis following normal mitosis and passage through mitotic G1 phase" EXACT [PomBase:vw] synonym: "abnormal mitosis following normal mitosis during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal mitotic nuclear division following normal mitotic nuclear division" EXACT [GO:0007067] synonym: "abnormal nuclear division following normal nuclear division during mitotic cell cycle" EXACT [PomBase:mah] is_a: FYPO:0000337 ! abnormal mitosis is_a: FYPO:0004593 ! abnormal vegetative cell phenotype following normal mitosis created_by: midori creation_date: 2015-04-29T12:16:40Z [Term] id: FYPO:0004589 name: abnormal gamma-tubulin complex localization to mitotic spindle pole body def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which localization of the gamma-tubulin complex to the spindle pole body is abnormal." [PomBase:mah] synonym: "abnormal gamma-tubulin complex localisation to mitotic spindle pole body" EXACT [PomBase:mah] synonym: "abnormal gamma-tubulin complex localization to mitotic SPB" EXACT [PomBase:mah] synonym: "abnormal gamma-tubulin complex localization to mitotic spindle pole body during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal gamma-tubulin complex localization to spindle pole body during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000939 ! abnormal protein localization to mitotic spindle pole body is_a: FYPO:0001440 ! abnormal protein complex localization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1990735 ! gamma-tubulin complex localization to mitotic spindle pole body intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1990735 ! gamma-tubulin complex localization to mitotic spindle pole body relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-04-29T15:36:44Z [Term] id: FYPO:0004590 name: abnormal gamma-tubulin complex localization to mitotic spindle pole body following normal mitosis def: "A cellular process phenotype in which localization of the gamma-tubulin complex to the spindle pole body takes place abnormally after the cell has undergone a normal mitotic nuclear division and passed through the subsequent mitotic interphase." [PomBase:mah] synonym: "abnormal gamma-tubulin complex localisation to mitotic spindle pole body following normal mitosis" EXACT [PomBase:mah] synonym: "abnormal gamma-tubulin complex localization to mitotic SPB following normal mitosis" EXACT [PomBase:mah] synonym: "abnormal gamma-tubulin complex localization to mitotic spindle pole body following normal mitosis and interphase" EXACT [PomBase:mah] synonym: "abnormal gamma-tubulin complex localization to mitotic spindle pole body following normal mitosis and passage through mitotic G1 phase" EXACT [PomBase:vw] synonym: "abnormal gamma-tubulin complex localization to mitotic spindle pole body following normal mitosis during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal gamma-tubulin complex localization to mitotic spindle pole body nuclear division following normal mitotic nuclear division" EXACT [GO:0007067] synonym: "abnormal gamma-tubulin complex localization to spindle pole body following normal nuclear division during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0004589 ! abnormal gamma-tubulin complex localization to mitotic spindle pole body is_a: FYPO:0004593 ! abnormal vegetative cell phenotype following normal mitosis created_by: midori creation_date: 2015-04-29T15:40:33Z [Term] id: FYPO:0004591 name: monopolar mitotic spindle following normal mitosis def: "A physical cellular phenotype in which the mitotic spindle forms with microtubules emanating from only one pole after the cell has undergone a normal mitotic nuclear division and passed through the subsequent mitotic interphase." [PomBase:mah] comment: This phenotype affects the second round of mitosis to take place after a mutation exerts its effect. For example, if a conditional mutant is shifted to restrictive conditions in G1 or S phase and the first mitosis thereafter is normal, but the spindle becomes monopolar in the second (even if cells are returned to permissive conditions in the second G1 or S phase), this term is applicable. synonym: "monopolar mitotic spindle following normal mitosis and interphase" EXACT [PomBase:mah] synonym: "monopolar mitotic spindle following normal mitosis and passage through mitotic G1 phase" EXACT [PomBase:vw] synonym: "monopolar mitotic spindle following normal mitosis during vegetative growth" EXACT [PomBase:mah] synonym: "monopolar mitotic spindle following normal mitotic nuclear division" EXACT [GO:0007067] synonym: "monopolar mitotic spindle following normal nuclear division during mitotic cell cycle" EXACT [PomBase:mah] is_a: FYPO:0000276 ! monopolar mitotic spindle is_a: FYPO:0004593 ! abnormal vegetative cell phenotype following normal mitosis created_by: midori creation_date: 2015-04-29T15:54:05Z [Term] id: FYPO:0004592 name: cut following normal mitosis def: "An inviable phenotype observed in the vegetative growth phase of the life cycle in which a cell becomes cut after it has undergone a normal mitotic nuclear division and passed through the subsequent mitotic interphase. In a cut phenotype, a cell undergoes septation despite abnormal chromosome segregation, such that the septum physically divides the nucleus into two parts, and produces inviable daughter cells." [PomBase:mah] comment: This phenotype affects the second round of mitosis to take place after a mutation exerts its effect. For example, if a conditional mutant is shifted to restrictive conditions in G1 or S phase and the first mitosis thereafter is normal, but the second results in a cut cell (even if cells are returned to permissive conditions in the second G1 or S phase), this term is applicable. synonym: "cut following normal mitosis and interphase" EXACT [PomBase:mah] synonym: "cut following normal mitosis and passage through mitotic G1 phase" EXACT [PomBase:vw] synonym: "cut following normal mitosis during vegetative growth" EXACT [PomBase:mah] synonym: "cut following normal mitotic nuclear division" EXACT [GO:0007067] synonym: "cut following normal nuclear division during mitotic cell cycle" EXACT [PomBase:mah] is_a: FYPO:0003165 ! cut is_a: FYPO:0004593 ! abnormal vegetative cell phenotype following normal mitosis created_by: midori creation_date: 2015-04-29T15:56:48Z [Term] id: FYPO:0004593 name: abnormal vegetative cell phenotype following normal mitosis def: "A phenotype that shows detectable differences from normal at the level of an individual cell, when the cell is in the vegetative growth phase of the cell cycle, and after it has undergone a normal mitotic nuclear division and passed through the subsequent mitotic interphase." [PomBase:mah] comment: This phenotype affects the second round of mitosis to take place after a mutation exerts its effect. For example, if a conditional mutant is shifted to restrictive conditions in G1 or S phase and the first mitosis thereafter is normal, but an abnormality arises in the second (even if cells are returned to permissive conditions in the second G1 or S phase), a descendant of this term is applicable. subset: qc_do_not_manually_annotate synonym: "abnormal cell phenotype following normal mitosis during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal vegetative cell phenotype following normal mitosis and interphase" EXACT [PomBase:mah] synonym: "abnormal vegetative cell phenotype following normal mitosis and passage through mitotic G1 phase" EXACT [PomBase:vw] synonym: "abnormal vegetative cell phenotype following normal mitotic nuclear division" EXACT [GO:0007067] synonym: "abnormal vegetative cell phenotype following normal nuclear division during mitotic cell cycle" EXACT [PomBase:mah] is_a: FYPO:0003755 ! abnormal vegetative cell phenotype created_by: midori creation_date: 2015-04-29T15:59:40Z [Term] id: FYPO:0004594 name: branched, elongated, septated cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is branched, septated and longer than normal." [PomBase:jh, PomBase:mah, PomBase:vw] comment: These cells often form a branch at a non-right angle to the long axis of the mother cell, near the septum. synonym: "branched, elongated, septated cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "branched, elongated, septated cell during vegetative growth" EXACT [PomBase:mah] synonym: "branched, elongated, septated vegetative cell" EXACT [PomBase:mah] synonym: "branched, long, septated cell" EXACT [PomBase:vw] is_a: FYPO:0001512 ! branched, elongated cell is_a: FYPO:0004750 ! elongated septated vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000015 ! branched vegetative cell intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0002342 ! septated vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000015 ! branched vegetative cell relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0002342 ! septated vegetative cell created_by: midori creation_date: 2015-04-29T16:37:35Z [Term] id: FYPO:0004595 name: abnormal gamma-tubulin complex assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which gamma-tubulin complex assembly is abnormal." [PomBase:mah] synonym: "abnormal gamma-tubulin complex assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal gamma-tubulin complex assembly during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000447 ! abnormal protein complex assembly intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1902481 ! gamma-tubulin complex assembly intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1902481 ! gamma-tubulin complex assembly relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-04-29T16:57:11Z [Term] id: FYPO:0004596 name: abnormal negative regulation of DNA replication initiation during mitotic G2 phase resulting in complete rereplication def: "A regulation phenotype observed in the vegetative growth phase of the life cycle in which negative regulation of the initiation of DNA-dependent DNA replication is abnormal during G2 phase of the mitotic cell cycle, resulting in one or more rounds of rereplication of the entire genome." [PMID:11532929, PomBase:mah] synonym: "abnormal negative regulation of DNA replication initiation during G2 phase resulting in complete rereplication during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal negative regulation of DNA replication initiation during mitotic G2 phase during vegetative growth, resulting in complete rereplication" EXACT [PomBase:mah] synonym: "abnormal negative regulation of DNA replication initiation during mitotic G2 phase resulting in complete re-replication" EXACT [PomBase:mah] synonym: "abnormal negative regulation of DNA-dependent DNA replication initiation during mitotic G2 phase resulting in complete rereplication" EXACT [PomBase:mah] is_a: FYPO:0001425 ! abnormal negative regulation of mitotic DNA replication initiation resulting in complete rereplication created_by: midori creation_date: 2015-04-29T16:58:57Z [Term] id: FYPO:0004597 name: replication origin firing during mitotic G2 phase def: "A regulation phenotype observed in the vegetative growth phase of the life cycle in which DNA replication is initiated at one or more origins during G2 phase of the mitotic cell cycle." [PMID:11532929, PomBase:mah] synonym: "replication origin firing during G2 phase of mitotic cell cycle" EXACT [PomBase:mah] synonym: "replication origin firing during mitotic G2 phase during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001248 ! abnormal regulation of mitotic DNA replication initiation created_by: midori creation_date: 2015-04-29T17:01:38Z [Term] id: FYPO:0004598 name: increased protein localization to chromatin during mitotic G2 phase def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to chromatin is increased during G2 phase of the mitotic cell cycle." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to chromatin during mitotic G2 phase" EXACT [PomBase:mah] synonym: "increased protein localization to chromatin during mitotic G2 phase during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003011 ! increased protein localization to chromatin intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0000085 ! mitotic G2 phase intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0071168 ! protein localization to chromatin relationship: happens_during GO:0000085 ! mitotic G2 phase relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0071168 ! protein localization to chromatin created_by: midori creation_date: 2015-04-29T17:03:36Z [Term] id: FYPO:0004599 name: increased rate of DNA replication during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the rate, or speed, of DNA replication is increased." [PomBase:mah] synonym: "increased rate of DNA replication during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001343 ! abnormal mitotic DNA replication is_a: PATO:0000912 ! increased rate intersection_of: PATO:0000912 ! increased rate intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902969 ! mitotic DNA replication relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902969 ! mitotic DNA replication created_by: midori creation_date: 2015-04-29T17:06:18Z [Term] id: FYPO:0004600 name: normal transcriptional response to pheromone def: "A conjugation phenotype in which regulation of transcription in response to mating pheromone is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [GO:0046019, PomBase:mah] is_a: FYPO:0000627 ! normal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0046019 ! regulation of transcription from RNA polymerase II promoter by pheromones intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0046019 ! regulation of transcription from RNA polymerase II promoter by pheromones relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-04-29T17:08:24Z [Term] id: FYPO:0004601 name: normal S-phase DNA damage checkpoint during cellular response to hydroxyurea def: "A cell cycle checkpoint phenotype in which the S-phase DNA damage checkpoint (also known as the intra-S phase DNA damage checkpoint) is normal (i.e. indistinguishable from wild type) when the cell is exposed to hydroxyurea. The S phase DNA damage checkpoint slows progression through S phase in response to DNA damage." [PomBase:mah] synonym: "normal intra-S phase DNA damage checkpoint during cellular response to hydroxyurea" EXACT [GO:0031573] synonym: "normal S-phase DNA damage checkpoint activation during cellular response to hydroxyurea" EXACT [PomBase:al] synonym: "normal S-phase DNA damage checkpoint during cellular response to HU" EXACT [PomBase:mah] synonym: "normal S-phase DNA damage checkpoint during cellular response to hydroxyurea during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal S-phase DNA damage checkpoint during cellular response to hydroxyurea during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001929 ! normal cell cycle regulation during cellular response to hydroxyurea is_a: FYPO:0003530 ! normal S-phase DNA damage checkpoint intersection_of: PATO:0000001 ! quality intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: during GO:0072711 ! cellular response to hydroxyurea intersection_of: inheres_in GO:0031573 ! intra-S DNA damage checkpoint intersection_of: qualifier PATO:0000461 ! normal relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: during GO:0072711 ! cellular response to hydroxyurea relationship: inheres_in GO:0031573 ! intra-S DNA damage checkpoint relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-04-30T15:20:21Z [Term] id: FYPO:0004602 name: normal linear element morphology def: "A physical cellular phenotype in which the size, shape, or structure of all or part of the linear element is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0001233 ! normal subcellular component is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: inheres_in GO:0030998 ! linear element intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0030998 ! linear element relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-04-30T15:25:23Z [Term] id: FYPO:0004603 name: inviable after spore germination, without cell division, elongated cell def: "A phenotype in which a spore germinates to produce an inviable cell that does not divide and is longer than normal." [PMID:7957061, PomBase:mah] synonym: "essential; germinating spore, without cell division, elongated cell" RELATED [PomBase:mah] synonym: "inviable following spore germination, without cell division, elongated cell" EXACT [PomBase:mah] synonym: "inviable germinated spore, without cell division, elongated cell" EXACT [PomBase:mah] is_a: FYPO:0001490 ! inviable elongated vegetative cell is_a: FYPO:0001991 ! inviable after spore germination, without cell division created_by: midori creation_date: 2015-05-01T14:49:23Z [Term] id: FYPO:0004604 name: decreased chromatin silencing at subtelomere def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of chromatin silencing at subtelomeric regions is decreased." [PomBase:mah] synonym: "decreased chromatin silencing at subtelomere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased chromatin silencing at subtelomere during vegetative growth" EXACT [PomBase:mah] synonym: "reduced chromatin silencing at subtelomere" EXACT [PomBase:mah] is_a: FYPO:0002353 ! decreased chromatin silencing created_by: midori creation_date: 2015-05-01T14:58:39Z [Term] id: FYPO:0004605 name: decreased horsetail movement def: "A cellular process phenotype in which the occurrence of horsetail movement is decreased. Horsetail movement is the oscillatory movement of the nucleus that takes place during meiotic prophase I." [GO:0030989, PomBase:mah] synonym: "decreased dynein-driven meiotic oscillatory nuclear movement" EXACT [GO:0030989] synonym: "decreased horsetail nuclear movement" EXACT [GO:0030989] synonym: "reduced horsetail movement" EXACT [PomBase:mah] is_a: FYPO:0000197 ! abnormal horsetail movement is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0030989 ! dynein-driven meiotic oscillatory nuclear movement relationship: inheres_in GO:0030989 ! dynein-driven meiotic oscillatory nuclear movement created_by: midori creation_date: 2015-05-01T15:08:53Z [Term] id: FYPO:0004606 name: normal protein level during meiotic cell cycle def: "A cell phenotype in which the amount of protein measured in a cell during the meiotic cell cycle is normal (i.e. indistinguishable from wild type). Total protein or a specific protein may be affected." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal cellular protein level during meiotic cell cycle" EXACT [PomBase:mah] synonym: "normal protein accumulation during meiotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0004083 ! normal protein level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0051321 ! meiotic cell cycle intersection_of: inheres_in CL:0000000 ! cell intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0051321 ! meiotic cell cycle relationship: inheres_in CL:0000000 ! cell relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2015-05-01T15:22:58Z [Term] id: FYPO:0004607 name: abnormal spindle pole body morphology def: "A physical cellular phenotype in which the size, shape, or structure of the spindle pole body is abnormal." [PomBase:mah] comment: Note that an abnormal spindle pole body organization process may, but does not necessarily, result in abnormal spindle pole body structure. synonym: "abnormal SPB morphology" EXACT [PomBase:mah] synonym: "abnormal spindle pole body structure" NARROW [PomBase:mah] is_a: FYPO:0000287 ! abnormal subcellular component is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: inheres_in GO:0005816 ! spindle pole body intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0005816 ! spindle pole body relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-05-01T15:25:17Z [Term] id: FYPO:0004608 name: abnormal spindle pole body morphology during meiosis II def: "A physical cellular phenotype in which the size, shape, or structure of the spindle pole body is abnormal during the second meiotic nuclear division." [PomBase:mah] comment: Note that an abnormal spindle pole body organization process may, but does not necessarily, result in abnormal spindle pole body structure. synonym: "abnormal SPB morphology during meiosis II" EXACT [PomBase:mah] synonym: "abnormal spindle pole body morphology during second meiotic nuclear division" EXACT [PomBase:mah] synonym: "abnormal spindle pole body structure during meiosis II" NARROW [PomBase:mah] is_a: FYPO:0004607 ! abnormal spindle pole body morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0007135 ! meiosis II intersection_of: inheres_in GO:0035974 ! meiotic spindle pole body intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0007135 ! meiosis II relationship: inheres_in GO:0035974 ! meiotic spindle pole body relationship: output_of FYPO:0003561 ! abnormal prospore-specific spindle pole body remodeling relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-05-01T15:25:51Z [Term] id: FYPO:0004609 name: spindle pole bodies present in greater numbers during meiosis def: "A physical cellular phenotype in which cells contain more spindle pole bodies (SPBs) than normal during one or both meiotic nuclear divisions. In this phenotype, extra SPBs typically contain normal components but seldom attach to spindle microtubules." [PMID:15569158, PomBase:mah] synonym: "excess meiotic spindle pole bodies present" EXACT [PomBase:mah] synonym: "excess spindle pole bodies present during meiosis" EXACT [PomBase:mah] synonym: "extra spindle pole bodies present during meiosis" EXACT [PomBase:mah] synonym: "pseudo-SPBs present during meiosis" EXACT [PMID:15569158] synonym: "SPBs present in greater numbers during meiosis" EXACT [PomBase:mah] is_a: FYPO:0000287 ! abnormal subcellular component is_a: PATO:0002002 ! has extra parts of type intersection_of: PATO:0002002 ! has extra parts of type intersection_of: towards GO:0035974 ! meiotic spindle pole body relationship: towards GO:0035974 ! meiotic spindle pole body created_by: midori creation_date: 2015-05-01T15:50:12Z [Term] id: FYPO:0004610 name: increased duration of meiotic prophase I def: "A cellular process phenotype in which the duration of prophase of the first meiotic nuclear division is longer than normal." [PomBase:mah] synonym: "long meiotic prophase I" EXACT [PomBase:mah] synonym: "prolonged meiotic prophase I" EXACT [PomBase:mah] is_a: FYPO:0000051 ! abnormal meiosis is_a: FYPO:0000408 ! increased duration of cell cycle phase intersection_of: PATO:0000498 ! increased duration intersection_of: inheres_in GO:0007128 ! meiotic prophase I relationship: inheres_in GO:0007128 ! meiotic prophase I created_by: midori creation_date: 2015-05-01T16:10:09Z [Term] id: FYPO:0004611 name: long cytoplasmic interphase microtubules def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells form cytoplasmic microtubules that are longer than normal during interphase of the mitotic cell cycle." [PomBase:mah] synonym: "elongated cytoplasmic interphase microtubules" EXACT [PomBase:mah] synonym: "long cytoplasmic interphase microtubules during vegetative growth" EXACT [PomBase:mah] synonym: "long cytoplasmic microtubules during interphase of mitotic cell cycle" EXACT [PomBase:mah] synonym: "long cytoplasmic microtubules during mitotic interphase" EXACT [PomBase:mah] is_a: FYPO:0000233 ! long cytoplasmic microtubules is_a: FYPO:0003625 ! abnormal microtubule cytoskeleton morphology during mitotic interphase intersection_of: PATO:0000573 ! increased length intersection_of: exists_during GO:0051329 ! mitotic interphase intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005881 ! cytoplasmic microtubule relationship: exists_during GO:0051329 ! mitotic interphase relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005881 ! cytoplasmic microtubule created_by: midori creation_date: 2015-05-01T16:15:17Z [Term] id: FYPO:0004612 name: long astral microtubules def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells form astral microtubules that are longer than normal." [PomBase:mah] synonym: "elongated astral microtubules" EXACT [PomBase:mah] synonym: "long astral microtubules during mitotic cell cycle" RELATED [PomBase:mah] synonym: "long astral microtubules during vegetative growth" EXACT [PomBase:mah] synonym: "long cytoplasmic astral microtubules" EXACT [PomBase:vw] is_a: FYPO:0000233 ! long cytoplasmic microtubules intersection_of: PATO:0000573 ! increased length intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000235 ! astral microtubule relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000235 ! astral microtubule created_by: midori creation_date: 2015-05-01T16:23:12Z [Term] id: FYPO:0004613 name: spindle pole body detached from cytoplasmic microtubules def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the spindle pole body is not attached to any cytoplasmic microtubules. Normally, the spindle pole body is attached to a single cytoplasmic microtubule bundle." [PMID:15772152, PomBase:mah] comment: This phenotype may result from either absence of the microtubule bundle that would normally attach to the SPB, or from a problem with the SPB-microtubule attachment process. synonym: "cytoplasmic microtubules absent from mitotic spindle pole body" EXACT [PomBase:vw] synonym: "SPB detached from cytoplasmic microtubules" EXACT [PomBase:mah] synonym: "spindle pole body detached from cytoplasmic microtubules during mitotic cell cycle" RELATED [PomBase:mah] synonym: "spindle pole body detached from cytoplasmic microtubules during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001474 ! abnormal spindle pole body morphology during vegetative growth is_a: PATO:0001453 ! detached from intersection_of: PATO:0001453 ! detached from intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0044732 ! mitotic spindle pole body intersection_of: towards GO:0005881 ! cytoplasmic microtubule relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0044732 ! mitotic spindle pole body relationship: towards GO:0005881 ! cytoplasmic microtubule created_by: midori creation_date: 2015-05-05T13:11:24Z [Term] id: FYPO:0004614 name: abnormal microtubule polymerization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which microtubule polymerization, i.e. the addition of tubulin dimers to the plus end of a microtubule, is abnormal." [GO:0046785, PomBase:mah] synonym: "abnormal microtubule polymerization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal microtubule polymerization during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000901 ! abnormal microtubule polymerization or depolymerization intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0046785 ! microtubule polymerization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0046785 ! microtubule polymerization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-05-05T13:33:03Z [Term] id: FYPO:0004615 name: increased rate of cytoplasmic microtubule polymerization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which cytoplasmic microtubule polymerization, i.e. the addition of tubulin dimers to the plus end of a cytoplasmic microtubule, occurs at a higher rate, or speed, than normal." [GO:0046785, PomBase:mah] synonym: "increased cytoplasmic microtubule polymerization rate" EXACT [PomBase:mah] synonym: "increased microtubule plus end growth rate" EXACT [PomBase:vw] synonym: "increased rate of cytoplasmic microtubule polymerization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased rate of cytoplasmic microtubule polymerization during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0004614 ! abnormal microtubule polymerization is_a: PATO:0000912 ! increased rate intersection_of: PATO:0000912 ! increased rate intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0046785 ! microtubule polymerization relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0046785 ! microtubule polymerization created_by: midori creation_date: 2015-05-05T13:39:51Z [Term] id: FYPO:0004616 name: abolished cytoplasmic microtubule depolymerization at plus end at cell tip def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which cytoplasmic microtubule depolymerization, i.e. the removal of tubulin dimers from a cytoplasmic microtubule, does not occur at the plus end of the microtubule at the cell tip. Normally, rapid depolymerization takes place when the growing plus end of the microtubule reaches the cell tip." [GO:0070462, PMID:15772152, PomBase:mah] synonym: "abolished cytoplasmic microtubule depolymerization at plus end at cell tip during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished cytoplasmic microtubule depolymerization at plus end at cell tip during vegetative growth" EXACT [PomBase:mah] synonym: "abolished microtubule catastrophe at cell tip" RELATED [PomBase:vw] synonym: "abolished microtubule plus end shrinkage at cell tip" RELATED [PomBase:vw] synonym: "abolished plus-end specific microtubule depolymerization at cell tip" EXACT [GO:0070462] synonym: "cytoplasmic microtubule depolymerization at plus end at cell tip abolished" EXACT [PomBase:mah] is_a: FYPO:0000902 ! abnormal microtubule depolymerization created_by: midori creation_date: 2015-05-05T13:59:40Z [Term] id: FYPO:0004617 name: increased rate of microtubule depolymerization at minus end def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which minus-end specific microtubule depolymerization, i.e. the removal of tubulin dimers from the minus end of a microtubule, occurs at a greater rate, or speed, than normal." [GO:0036078, PomBase:mah] synonym: "decreased microtubule stability" RELATED [PomBase:vw] synonym: "increased microtubule depolymerization rate at minus end" EXACT [PomBase:mah] synonym: "increased microtubule minus end shrinkage" RELATED [PomBase:vw] synonym: "increased rate of microtubule depolymerization at minus end during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased rate of microtubule depolymerization at minus end during vegetative growth" EXACT [PomBase:mah] synonym: "increased rate of minus-end specific microtubule depolymerization" EXACT [GO:0036078] is_a: FYPO:0003194 ! increased rate of microtubule depolymerization intersection_of: PATO:0000912 ! increased rate intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0036078 ! minus-end specific microtubule depolymerization relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0036078 ! minus-end specific microtubule depolymerization created_by: midori creation_date: 2015-05-05T14:03:39Z [Term] id: FYPO:0004618 name: astral microtubules absent from cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the cell does not contain detectable astral microtubules." [PomBase:mah] synonym: "absent astral microtubules" EXACT [PomBase:mah] synonym: "astral microtubules absent from cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "astral microtubules absent from cell during vegetative growth" EXACT [PomBase:mah] synonym: "cytoplasmic astral microtubules absent from cell" EXACT [PomBase:vw] is_a: FYPO:0004702 ! cytoplasmic microtubules absent from cell intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards GO:0000235 ! astral microtubule relationship: inheres_in CL:0000000 ! cell relationship: towards GO:0000235 ! astral microtubule created_by: midori creation_date: 2015-05-05T14:20:14Z [Term] id: FYPO:0004619 name: cytoplasmic microtubules nucleated from equatorial microtubule organizing center absent from cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the cell does not contain detectable cytoplasmic microtubules nucleated from the equatorial microtubule organizing center." [PMID:15772152, PomBase:mah] synonym: "cytoplasmic microtubules nucleated from eMTOC absent from cell" EXACT [PomBase:mah] synonym: "cytoplasmic microtubules nucleated from equatorial microtubule organizing center absent from cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "cytoplasmic microtubules nucleated from equatorial microtubule organizing center absent from cell during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0004702 ! cytoplasmic microtubules absent from cell created_by: midori creation_date: 2015-05-05T15:03:04Z [Term] id: FYPO:0004620 name: abnormal spindle disassembly def: "A cellular process phenotype in which spindle disassembly is abnormal. Spindle disassembly is the controlled breakdown of the spindle." [GO:0051230, PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_manually_annotate is_a: FYPO:0000054 ! abnormal microtubule cytoskeleton organization is_a: FYPO:0002734 ! abnormal cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0051230 ! spindle disassembly intersection_of: qualifier PATO:0000460 ! abnormal relationship: has_output FYPO:0004438 ! long mitotic spindle during anaphase relationship: inheres_in_part_of GO:0051230 ! spindle disassembly relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-05-05T15:09:51Z [Term] id: FYPO:0004621 name: abnormal mitotic spindle disassembly def: "A cellular process phenotype in which disassembly of the mitotic spindle is abnormal." [PomBase:mah] synonym: "abnormal spindle disassembly during mitosis" EXACT [PomBase:mah] synonym: "abnormal spindle disassembly during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001350 ! abnormal microtubule cytoskeleton organization during vegetative growth is_a: FYPO:0002737 ! abnormal mitotic cell cycle process is_a: FYPO:0004620 ! abnormal spindle disassembly intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0051228 ! mitotic spindle disassembly intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0051228 ! mitotic spindle disassembly relationship: part_of FYPO:0000337 ! abnormal mitosis relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-05-05T15:10:09Z [Term] id: FYPO:0004622 name: abolished mitotic spindle disassembly def: "A cell phenotype in which mitotic spindle disassembly does not occur." [PomBase:mah] comment: When the mitotic spindle is not disassembled, it can become bent or S-shaped, and remains present in the cell after anaphase. synonym: "abolished mitotic spindle disassembly during vegetative growth" EXACT [PomBase:mah] synonym: "spindle disassembly involved in mitosis abolished" EXACT [PomBase:mah] is_a: FYPO:0004621 ! abnormal mitotic spindle disassembly is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0051228 ! mitotic spindle disassembly relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0051228 ! mitotic spindle disassembly created_by: midori creation_date: 2015-05-05T15:11:01Z [Term] id: FYPO:0004623 name: abolished astral microtubule anchoring at mitotic spindle pole body def: "A cell phenotype in which astral microtubule anchoring at the mitotic spindle pole body does not occur." [PMID:15004232, PomBase:mah] synonym: "abolished astral microtubule anchoring at mitotic spindle pole body during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished astral microtubule anchoring at mitotic spindle pole body during vegetative growth" EXACT [PomBase:mah] synonym: "astral microtubule anchoring at mitotic spindle pole body abolished" EXACT [PomBase:mah] is_a: FYPO:0000054 ! abnormal microtubule cytoskeleton organization is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1990734 ! astral microtubule anchoring at mitotic spindle pole body relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1990734 ! astral microtubule anchoring at mitotic spindle pole body created_by: midori creation_date: 2015-05-05T15:20:37Z [Term] id: FYPO:0004624 name: abolished equatorial microtubule organizing center assembly def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which equatorial microtubule organizing center (eMTOC) assembly does not occur. eMTOC assembly is the aggregation, arrangement and bonding together of a set of components to form an equatorial microtubule organizing center." [GO:1904185, PMID:15004232, PomBase:mah] synonym: "abolished eMTOC assembly" EXACT [GO:1904185] synonym: "abolished eMTOC formation" EXACT [PomBase:mah] synonym: "abolished equatorial microtubule organizing center assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished equatorial microtubule organizing center assembly during vegetative growth" EXACT [PomBase:mah] synonym: "abolished equatorial microtubule organizing center formation" EXACT [GO:1904185] synonym: "equatorial microtubule organizing center assembly abolished" EXACT [PomBase:mah] is_a: FYPO:0001350 ! abnormal microtubule cytoskeleton organization during vegetative growth is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1904185 ! equatorial microtubule organizing center assembly relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1904185 ! equatorial microtubule organizing center assembly created_by: midori creation_date: 2015-05-05T15:24:59Z [Term] id: FYPO:0004625 name: abnormal post-anaphase microtubule array organization def: "A microtubule cytoskeleton organization phenotype observed in the vegetative growth phase of the life cycle in which post-anaphase microtubule array organization is abnormal. Post-anaphase microtubule array organization is a cellular process that results in the assembly, arrangement of constituent parts, or disassembly of the post-anaphase microtubule array." [PMID:1904186, PomBase:mah] comment: Note that an abnormal post-anaphase microtubule array organization process may, but does not necessarily, result in abnormal post-anaphase microtubule array structure. synonym: "abnormal PAA organization" EXACT [GO:1904186] synonym: "abnormal post-anaphase array organization" EXACT [GO:1904186] synonym: "abnormal post-anaphase microtubule array organization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal post-anaphase microtubule array organization during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001350 ! abnormal microtubule cytoskeleton organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1904186 ! post-anaphase microtubule array organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1904186 ! post-anaphase microtubule array organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-05-05T15:38:26Z [Term] id: FYPO:0004626 name: inviable curved elongated mononucleate vegetative cell def: "A cell morphology phenotype in which a vegetatively growing cell is inviable, is longer than normal, is curved along the long axis, and contains one nucleus. In a curved cell, the long axis follows a smooth bend rather than a straight line." [PomBase:mah] synonym: "essential; curved elongated mononucleate vegetative cell" RELATED [PomBase:mah] synonym: "inviable curved elongated mononucleate cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable curved elongated mononucleate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0002411 ! inviable curved elongated vegetative cell is_a: FYPO:0004255 ! inviable elongated mononucleate vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000016 ! curved vegetative cell intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000060 ! mononucleate vegetative cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000016 ! curved vegetative cell relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000060 ! mononucleate vegetative cell relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2015-05-05T17:43:34Z [Term] id: FYPO:0004627 name: inviable after spore germination, multiple cell divisions, chromosome fragmentation upon segregation def: "A phenotype in which a spore germinates to produce a cell that undergoes two or more rounds of cell division during which chromosomes are broken during mitotic chromosome segregation, and then dies." [PMID:10572171, PomBase:al, PomBase:mah] synonym: "essential; germinating spore, multiple cell divisions,chromosome fragmentation upon segregation" RELATED [PomBase:mah] synonym: "inviable following spore germination, multiple cell divisions, chromosome fragmentation upon segregation" EXACT [PomBase:mah] synonym: "inviable germinated spore, multiple cell divisions, chromosome fragmentation upon segregation" EXACT [PomBase:mah] is_a: FYPO:0002430 ! inviable after spore germination, multiple cell divisions created_by: midori creation_date: 2015-05-06T14:14:53Z [Term] id: FYPO:0004628 name: delayed premeiotic DNA replication def: "A cellular process phenotype in which premeiotic DNA replication begins later than normal." [PomBase:mah] is_a: FYPO:0000625 ! abnormal premeiotic DNA replication is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: inheres_in GO:0006279 ! premeiotic DNA replication relationship: inheres_in GO:0006279 ! premeiotic DNA replication created_by: midori creation_date: 2015-05-06T14:17:00Z [Term] id: FYPO:0004629 name: normal mitotic DNA replication def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitotic DNA replication is normal." [PomBase:mah] synonym: "normal DNA replication during mitotic cell cycle" EXACT [PomBase:mah] synonym: "normal DNA replication during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001133 ! normal DNA replication is_a: FYPO:0002741 ! normal mitotic cell cycle process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:1902969 ! mitotic DNA replication intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:1902969 ! mitotic DNA replication relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-05-06T14:18:54Z [Term] id: FYPO:0004630 name: decreased RNA level during meiotic cell cycle def: "A cell phenotype in which the amount of RNA measured in a cell is lower than normal during the meiotic cell cycle. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "decreased RNA accumulation during meiotic cell cycle" RELATED [PomBase:mah] synonym: "decreased transcript level during meiotic cell cycle" EXACT [PomBase:vw] synonym: "reduced RNA level during meiotic cell cycle" EXACT [PomBase:mah] is_a: FYPO:0000826 ! decreased RNA level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0051321 ! meiotic cell cycle intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0051321 ! meiotic cell cycle relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2015-05-06T14:26:55Z [Term] id: FYPO:0004631 name: decreased protein level during meiotic anaphase I def: "A cell phenotype in which the amount of protein measured in a cell during anaphase of the first meiotic nuclear division is lower than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein accumulation during meiotic anaphase I" RELATED [PomBase:mah] synonym: "decreased protein level during anaphase of first meiotic nuclear division" EXACT [PomBase:mah] synonym: "reduced protein level during meiotic anaphase I" EXACT [PomBase:mah] is_a: FYPO:0000835 ! decreased protein level intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0007133 ! meiotic anaphase I intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0007133 ! meiotic anaphase I relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2015-05-06T16:23:38Z [Term] id: FYPO:0004632 name: decreased protein level during meiosis II def: "A cell phenotype in which the amount of protein measured in a cell during the second meiotic nuclear division is lower than normal. Total protein or a specific protein may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal translation or abnormal regulation of translation, but note that changes in protein levels may result from changes in protein stability or degradation as well as changes in protein synthesis. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein accumulation during meiosis II" RELATED [PomBase:mah] synonym: "decreased protein level during second meiotic nuclear division" EXACT [PomBase:mah] synonym: "reduced protein level during meiosis II" EXACT [PomBase:mah] is_a: FYPO:0003550 ! decreased protein level during meiosis intersection_of: PATO:0001163 ! decreased concentration intersection_of: exists_during GO:0007135 ! meiosis II intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0007135 ! meiosis II relationship: inheres_in CL:0000000 ! cell relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2015-05-06T16:25:03Z [Term] id: FYPO:0004633 name: decreased protein kinase activity during meiosis II def: "A molecular function phenotype in which the observed rate of a protein kinase activity is decreased during the second meiotic nuclear division." [PomBase:mah] synonym: "decreased protein kinase activity during second meiotic nuclear division" EXACT [PomBase:mah] synonym: "reduced protein kinase activity during meiosis II" EXACT [PomBase:mah] is_a: FYPO:0001382 ! decreased protein kinase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: during GO:0007135 ! meiosis II intersection_of: inheres_in GO:0004672 ! protein kinase activity relationship: during GO:0007135 ! meiosis II relationship: inheres_in GO:0004672 ! protein kinase activity created_by: midori creation_date: 2015-05-06T16:26:26Z [Term] id: FYPO:0004634 name: normal protein level during meiosis def: "A cell phenotype in which the amount of protein measured in a cell during one or both meiotic nuclear divisions is normal (i.e. indistinguishable from wild type). Total protein or a specific protein may be affected." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal cellular protein level during meiosis" EXACT [PomBase:mah] synonym: "normal protein accumulation during meiosis" RELATED [PomBase:mah] is_a: FYPO:0004083 ! normal protein level intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0007126 ! meiotic nuclear division intersection_of: inheres_in CL:0000000 ! cell intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards CHEBI:36080 ! protein relationship: exists_during GO:0007126 ! meiotic nuclear division relationship: inheres_in CL:0000000 ! cell relationship: qualifier PATO:0000461 ! normal relationship: towards CHEBI:36080 ! protein created_by: midori creation_date: 2015-05-06T16:28:14Z [Term] id: FYPO:0004635 name: increased protein localization to mitotic spindle def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the mitotic spindle is increased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to mitotic spindle" EXACT [PomBase:mah] synonym: "increased protein localization to spindle during mitosis" EXACT [PomBase:mah] synonym: "increased protein localization to spindle during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000932 ! increased protein localization to microtubule cytoskeleton during vegetative growth is_a: FYPO:0002824 ! abnormal protein localization to mitotic spindle intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902480 ! protein localization to mitotic spindle relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902480 ! protein localization to mitotic spindle created_by: midori creation_date: 2015-05-06T16:38:04Z [Term] id: FYPO:0004636 name: decreased 14-3-3 protein binding def: "A molecular function phenotype in which the binding of a protein to a 14-3-3 protein occurs to a lower extent than normal. The affected protein may be encoded by the mutated gene, or by a different gene." [PomBase:mah] comment: This term can be used for any interaction with actin filaments that is affected by a mutation, whether or not the mutated gene product is one of the interacting proteins. We recommend noting which proteins were used in the assay when annotating to this term. synonym: "reduced 14-3-3 protein binding" EXACT [PomBase:mah] is_a: FYPO:0001645 ! decreased protein binding intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0071889 ! 14-3-3 protein binding relationship: inheres_in GO:0071889 ! 14-3-3 protein binding created_by: midori creation_date: 2015-05-08T12:02:36Z [Term] id: FYPO:0004637 name: normal DNA polymerase activity def: "A molecular function phenotype in which the observed rate and other catalytic properties of a DNA polymerase activity are normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0003887 ! DNA-directed DNA polymerase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0003887 ! DNA-directed DNA polymerase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-05-08T12:04:03Z [Term] id: FYPO:0004638 name: abnormal cellular physical quality phenotype def: "A phenotype in which any physical object quality, such as morphology, number, location, etc., of a cell or a cellular component is abnormal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "abnormal cellular physical object quality" EXACT [PATO:0001241] is_a: FYPO:0000136 ! cellular physical quality phenotype is_a: FYPO:0001985 ! abnormal phenotype intersection_of: PATO:0001241 ! physical object quality intersection_of: inheres_in_part_of GO:0005575 ! cellular_component intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0005575 ! cellular_component relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-05-08T14:33:25Z [Term] id: FYPO:0004639 name: abnormal cellular physical quality phenotype during vegetative growth def: "A phenotype observed in the vegetative growth phase of the life cycle in which any physical object quality, such as morphology, number, location, etc., of a cell or a cellular component is abnormal." [PomBase:mah] comment: This is a high-level term whose primary purpose is to organize terms beneath it in the ontology, and we expect that it will not be used for direct annotations. Please consider using a more specific term to annotate each phenotype. subset: qc_do_not_annotate subset: qc_do_not_manually_annotate synonym: "abnormal cellular physical object quality during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal cellular physical quality phenotype during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001321 ! cellular physical quality phenotype during vegetative growth is_a: FYPO:0004638 ! abnormal cellular physical quality phenotype intersection_of: PATO:0001241 ! physical object quality intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:0005575 ! cellular_component intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:0005575 ! cellular_component relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-05-08T15:13:46Z [Term] id: FYPO:0004640 name: abnormal CAAX-protein geranylgeranyltransferase activity def: "A molecular function phenotype in which the observed rate of CAAX-protein geranylgeranyltransferase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004662 ! CAAX-protein geranylgeranyltransferase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004662 ! CAAX-protein geranylgeranyltransferase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-05-11T15:55:06Z [Term] id: FYPO:0004641 name: decreased CAAX-protein geranylgeranyltransferase activity def: "A molecular function phenotype in which the observed rate of CAAX-protein geranylgeranyltransferase activity is decreased." [PomBase:mah] synonym: "reduced CAAX-protein geranylgeranyltransferase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0004640 ! abnormal CAAX-protein geranylgeranyltransferase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004662 ! CAAX-protein geranylgeranyltransferase activity relationship: inheres_in GO:0004662 ! CAAX-protein geranylgeranyltransferase activity created_by: midori creation_date: 2015-05-11T15:55:13Z [Term] id: FYPO:0004642 name: normal protein farnesyltransferase activity def: "A molecular function phenotype in which the observed rate of a protein farnesyltransferase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004660 ! protein farnesyltransferase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0004660 ! protein farnesyltransferase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-05-11T15:56:44Z [Term] id: FYPO:0004643 name: normal Rab geranylgeranyltransferase activity def: "A molecular function phenotype in which the observed rate of Rab geranylgeranyltransferase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004663 ! Rab geranylgeranyltransferase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0004663 ! Rab geranylgeranyltransferase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-05-11T15:57:27Z [Term] id: FYPO:0004644 name: abnormal bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity def: "A molecular function phenotype in which the observed rate of bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity is abnormal." [PomBase:mah] synonym: "abnormal cysteine protease activity" EXACT [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004081 ! bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004081 ! bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-05-11T15:59:47Z [Term] id: FYPO:0004645 name: increased bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity def: "A molecular function phenotype in which the observed rate of bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity is increased." [PomBase:mah] is_a: FYPO:0000662 ! increased catalytic activity is_a: FYPO:0004644 ! abnormal bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity intersection_of: PATO:0002051 ! increased occurrence intersection_of: inheres_in GO:0004081 ! bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity relationship: inheres_in GO:0004081 ! bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity created_by: midori creation_date: 2015-05-11T15:59:52Z [Term] id: FYPO:0004646 name: normal duration of mitotic anaphase def: "A cell cycle phenotype in the duration of anaphase of mitosis normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0002740 ! normal mitotic cell cycle phase is_a: PATO:0001309 ! duration intersection_of: PATO:0001309 ! duration intersection_of: inheres_in GO:0000090 ! mitotic anaphase intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0000090 ! mitotic anaphase relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-05-11T16:17:31Z [Term] id: FYPO:0004647 name: increased RNA level during cellular response to copper ion def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to copper ions is higher than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased RNA accumulation during cellular response to copper ion" RELATED [PomBase:mah] synonym: "increased RNA level during cellular response to copper" EXACT [PomBase:mah] synonym: "increased RNA level during cellular response to copper ion during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased RNA level during cellular response to copper ion during vegetative growth" EXACT [PomBase:mah] synonym: "increased transcript level during cellular response to copper ion" EXACT [PomBase:vw] is_a: FYPO:0000825 ! increased RNA level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0071280 ! cellular response to copper ion intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0071280 ! cellular response to copper ion relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2015-05-12T16:26:01Z [Term] id: FYPO:0004648 name: delayed mitotic spindle assembly def: "A cellular process phenotype in which assembly of the mitotic spindle begins later than normal." [GO:0090307, PomBase:mah] synonym: "delayed abnormal mitotic spindle assembly during vegetative growth" EXACT [PomBase:mah] synonym: "delayed bipolar mitotic spindle formation" EXACT [PomBase:al] synonym: "delayed spindle assembly during mitotic cell cycle" EXACT [PomBase:mah] synonym: "delayed spindle assembly during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000177 ! abnormal mitotic spindle assembly is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0090307 ! mitotic spindle assembly relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0090307 ! mitotic spindle assembly created_by: midori creation_date: 2015-05-27T14:25:46Z [Term] id: FYPO:0004649 name: abolished protein localization to mitotic spindle pole body during metaphase def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the mitotic spindle pole body during metaphase does not occur." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "protein absent from mitotic spindle pole body during metaphase" RELATED [PomBase:mah] synonym: "protein localisation to mitotic spindle pole body abolished during metaphase" EXACT [PomBase:mah] synonym: "protein localization to mitotic SPB abolished during metaphase" EXACT [PomBase:mah] synonym: "protein localization to mitotic spindle pole body abolished during metaphase" EXACT [PomBase:mah] synonym: "protein localization to spindle pole body abolished during metaphase during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000941 ! abolished protein localization to mitotic spindle pole body intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0000089 ! mitotic metaphase intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1902440 ! protein localization to mitotic spindle pole body relationship: during GO:0000089 ! mitotic metaphase relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1902440 ! protein localization to mitotic spindle pole body created_by: midori creation_date: 2015-05-27T14:40:16Z [Term] id: FYPO:0004650 name: decreased mitotic spindle microtubule depolymerization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitotic spindle microtubule depolymerization, i.e. the removal of tubulin dimers from a microtubule in the mitotic spindle, occurs to a lesser extent than normal." [PomBase:mah] synonym: "decreased mitotic spindle microtubule depolymerisation" EXACT [PomBase:mah] synonym: "decreased mitotic spindle microtubule depolymerization during vegetative growth" EXACT [PomBase:mah] synonym: "decreased spindle microtubule depolymerization during mitotic cell cycle" EXACT [PomBase:mah] synonym: "reduced decreased mitotic spindle microtubule depolymerization" EXACT [PomBase:mah] is_a: FYPO:0000902 ! abnormal microtubule depolymerization is_a: FYPO:0000904 ! decreased microtubule polymerization or depolymerization intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1990755 ! mitotic spindle microtubule depolymerization relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1990755 ! mitotic spindle microtubule depolymerization created_by: midori creation_date: 2015-05-27T14:42:39Z [Term] id: FYPO:0004651 name: decreased secondary cell septum thickness def: "A septation phenotype observed in the vegetative growth phase of the life cycle in which a cell forms a secondary septum that is thinner than normal." [PomBase:mah] synonym: "decreased secondary cell septum thickness during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased secondary cell septum thickness during vegetative growth" EXACT [PomBase:mah] synonym: "decreased secondary septum thickness" EXACT [PomBase:mah] synonym: "reduced secondary cell septum thickness" EXACT [PomBase:mah] synonym: "thin secondary septum" EXACT [PomBase:mah] is_a: FYPO:0002023 ! abnormal septum morphology during vegetative growth is_a: PATO:0000592 ! decreased thickness intersection_of: PATO:0000592 ! decreased thickness intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051077 ! secondary cell septum relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051077 ! secondary cell septum created_by: midori creation_date: 2015-05-27T15:47:50Z [Term] id: FYPO:0004652 name: normal actomyosin contractile ring morphology def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the size, shape, and structure of the actomyosin contractile ring is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal actomyosin contractile ring morphology during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal actomyosin contractile ring morphology during vegetative growth" EXACT [PomBase:mah] synonym: "normal mitotic contractile ring morphology" EXACT [PomBase:vw] is_a: FYPO:0004740 ! normal actomyosin contractile ring is_a: PATO:0000051 ! morphology intersection_of: PATO:0000051 ! morphology intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005826 ! actomyosin contractile ring intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005826 ! actomyosin contractile ring relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-05-27T15:52:51Z [Term] id: FYPO:0004653 name: delayed actomyosin contractile ring contraction def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which actomyosin contractile ring contraction begins later than normal." [PomBase:mah] synonym: "delayed actomyosin contractile ring contraction during vegetative growth" EXACT [PomBase:mah] synonym: "delayed mitotic actomyosin contractile ring contraction" EXACT [GO:1902404, PomBase:mah] synonym: "delayed mitotic contractile ring contraction" EXACT [PomBase:vw] is_a: FYPO:0001364 ! abnormal actomyosin contractile ring contraction is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902404 ! mitotic actomyosin contractile ring contraction relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902404 ! mitotic actomyosin contractile ring contraction created_by: midori creation_date: 2015-05-27T15:54:37Z [Term] id: FYPO:0004654 name: thin, incomplete secondary cell septum def: "A septation phenotype observed in the vegetative growth phase of the life cycle in which a cell forms a secondary septum that is thinner than normal and does not extend over the entire cell division site." [PMID:25473118, PomBase:mah] synonym: "incomplete secondary cell septum with decreased thickness" EXACT [PomBase:mah] synonym: "incomplete secondary cell septum with reduced thickness" EXACT [PomBase:mah] synonym: "thin, discontinuous secondary septum" EXACT [PMID:25473118] synonym: "thin, incomplete secondary cell septum during mitotic cell cycle" RELATED [PomBase:mah] synonym: "thin, incomplete secondary cell septum during vegetative growth" EXACT [PomBase:mah] synonym: "thin, incomplete secondary septum" EXACT [PomBase:mah] is_a: FYPO:0002023 ! abnormal septum morphology during vegetative growth relationship: has_part FYPO:0004651 ! decreased secondary cell septum thickness created_by: midori creation_date: 2015-05-27T16:07:02Z [Term] id: FYPO:0004655 name: increased protein localization to cell division site def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the site of cell division is increased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to cell division site" EXACT [PomBase:mah] synonym: "increased protein localization to cell division site during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein localization to cell division site during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001401 ! abnormal protein localization to cell division site is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0072741 ! protein localization to cell division site relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0072741 ! protein localization to cell division site created_by: midori creation_date: 2015-05-27T16:15:46Z [Term] id: FYPO:0004656 name: increased protein localization to telomere def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the telomere of a chromosome is increased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased protein localisation to chromosome, telomeric region" EXACT [GO:0070198, PomBase:mah] synonym: "increased protein localisation to telomere" EXACT [PomBase:mah] synonym: "increased protein localization to chromosome, telomeric region" EXACT [GO:0070198, PomBase:mah] synonym: "increased protein localization to telomere during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased protein localization to telomere during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002840 ! increased protein localization to chromosome is_a: FYPO:0003108 ! abnormal protein localization to telomere intersection_of: PATO:0002051 ! increased occurrence intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0070198 ! protein localization to chromosome, telomeric region relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0070198 ! protein localization to chromosome, telomeric region created_by: midori creation_date: 2015-05-27T16:16:34Z [Term] id: FYPO:0004657 name: inviable mononucleate multiseptate vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is inviable, and has one nucleus and more than one septum." [PomBase:mah] synonym: "inviable mononucleate multiseptate cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable mononucleate multiseptate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000060 ! mononucleate vegetative cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0004295 ! multiseptate cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000060 ! mononucleate vegetative cell relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0004295 ! multiseptate cell created_by: midori creation_date: 2015-05-27T16:23:27Z [Term] id: FYPO:0004658 name: inviable binucleate multiseptate vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is inviable, and has two nuclei and more than one septum." [PomBase:mah] synonym: "inviable binucleate multiseptate cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable binucleate multiseptate vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0001222 ! binucleate vegetative cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell intersection_of: has_part FYPO:0004295 ! multiseptate cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0001222 ! binucleate vegetative cell relationship: has_part FYPO:0001489 ! inviable vegetative cell relationship: has_part FYPO:0004295 ! multiseptate cell created_by: midori creation_date: 2015-05-27T16:24:42Z [Term] id: FYPO:0004659 name: abolished protein tyrosine phosphorylation during cellular response to UV def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of tyrosine residues in one or more specific proteins, or of specific protein sites, does not occur during a cellular response to ultraviolet light." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein tyrosine phosphorylation during cellular response to ultraviolet light" EXACT [PomBase:mah] synonym: "abolished protein tyrosine phosphorylation during cellular response to UV during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein tyrosine phosphorylation during cellular response to UV during vegetative growth" EXACT [PomBase:mah] synonym: "protein phosphorylation abolished during cellular response to UV" EXACT [PomBase:mah] is_a: FYPO:0002288 ! abolished protein tyrosine phosphorylation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0034644 ! cellular response to UV intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0018108 ! peptidyl-tyrosine phosphorylation relationship: during GO:0034644 ! cellular response to UV relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0018108 ! peptidyl-tyrosine phosphorylation created_by: midori creation_date: 2015-05-27T16:25:40Z [Term] id: FYPO:0004660 name: abolished protein tyrosine phosphorylation during cellular response to methyl methanesulfonate def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of tyrosine residues in one or more specific proteins, or of specific protein sites, does not occur during a cellular response to methyl methanesulfonate." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein tyrosine phosphorylation during cellular response to methyl methanesulfonate during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein tyrosine phosphorylation during cellular response to methyl methanesulfonate during vegetative growth" EXACT [PomBase:mah] synonym: "abolished protein tyrosine phosphorylation during cellular response to methyl methanesulphonate" EXACT [PomBase:mah] synonym: "abolished protein tyrosine phosphorylation during cellular response to MMS" EXACT [PomBase:mah] synonym: "protein phosphorylation abolished during cellular response to methyl methanesulfonate" EXACT [PomBase:mah] is_a: FYPO:0002288 ! abolished protein tyrosine phosphorylation intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: during GO:0072703 ! cellular response to methyl methanesulfonate intersection_of: towards GO:0018108 ! peptidyl-tyrosine phosphorylation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: during GO:0072703 ! cellular response to methyl methanesulfonate relationship: towards GO:0018108 ! peptidyl-tyrosine phosphorylation created_by: midori creation_date: 2015-05-27T16:40:39Z [Term] id: FYPO:0004661 name: normal protein tyrosine phosphorylation during vegetative growth def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of tyrosine residues of one or more specific proteins is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein tyrosine phosphorylation during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0000776 ! normal protein phosphorylation during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0018108 ! peptidyl-tyrosine phosphorylation intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0018108 ! peptidyl-tyrosine phosphorylation relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-05-27T16:42:15Z [Term] id: FYPO:0004662 name: normal viability following cellular response to UV def: "A cell population phenotype in which a normal proportion of the population remains viable after exposure to ultraviolet light." [PomBase:mah] synonym: "normal cell population viability following cellular response to UV" EXACT [PomBase:mah] synonym: "normal viability following cellular response to ultraviolet light" EXACT [PomBase:mah] synonym: "normal viability following UV exposure" EXACT [PomBase:mah] is_a: FYPO:0000257 ! normal phenotype is_a: FYPO:0002057 ! cell population viability created_by: midori creation_date: 2015-05-27T16:44:03Z [Term] id: FYPO:0004663 name: normal viability following cellular response to methyl methanesulfonate def: "A cell population phenotype in which a normal proportion of the population remains viable after exposure to methyl methanesulfonate." [PomBase:mah] synonym: "normal cell population viability following cellular response to methyl methanesulfonate" EXACT [PomBase:mah] synonym: "normal viability following cellular response to methyl methanesulphonate" EXACT [PomBase:mah] synonym: "normal viability following cellular response to MMS" EXACT [PomBase:mah] synonym: "normal viability following MMS exposure" EXACT [PomBase:mah] is_a: FYPO:0000257 ! normal phenotype is_a: FYPO:0002057 ! cell population viability created_by: midori creation_date: 2015-05-27T16:45:37Z [Term] id: FYPO:0004664 name: increased duration of protein tyrosine phosphorylation during cellular response to salt stress def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the duration of protein phosphorylation on tyrosine residues is increased during a cellular response to salt stress. All protein tyrosine phosphorylation may be affected, or tyrosine residues in one or more specific proteins, or at specific protein sites, or even specific sites within specific proteins." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased duration of protein tyrosine phosphorylation during cellular response to salt stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased duration of protein tyrosine phosphorylation during cellular response to salt stress during vegetative growth" EXACT [PomBase:mah] synonym: "prolonged protein tyrosine phosphorylation during cellular response to salt stress" EXACT [PomBase:mah] is_a: FYPO:0000548 ! increased duration of protein modification intersection_of: PATO:0000498 ! increased duration intersection_of: happens_during GO:0018108 ! peptidyl-tyrosine phosphorylation intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006468 ! protein phosphorylation relationship: happens_during GO:0018108 ! peptidyl-tyrosine phosphorylation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006468 ! protein phosphorylation created_by: midori creation_date: 2015-05-27T17:11:02Z [Term] id: FYPO:0004665 name: linear elements absent from cell def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which linear elements are absent from the cell." [PomBase:mah] comment: In the absence of filamentous actin, a ring structure may form, but is not considered a contractile ring. synonym: "absent linear elements" EXACT [PomBase:al] synonym: "linear elements absent" EXACT [PomBase:mah] is_a: FYPO:0000287 ! abnormal subcellular component is_a: PATO:0002000 ! lacks all parts of type intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards GO:0030998 ! linear element relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards GO:0030998 ! linear element created_by: midori creation_date: 2015-05-28T11:33:11Z [Term] id: FYPO:0004666 name: decreased meiotic sister chromatid cohesion along chromosome arms def: "A cellular process phenotype in which cohesion between sister chromatids is decreased along the length of the chromosome arms during meiosis." [PomBase:mah] synonym: "abnormal sister chromatid cohesion along chromosome arms during meiosis" EXACT [PomBase:mah] synonym: "decreased meiotic sister chromatid cohesion, arms" EXACT [GO:0051760] synonym: "reduced meiotic sister chromatid cohesion along chromosome arms" EXACT [PomBase:mah] is_a: FYPO:0002093 ! decreased meiotic sister chromatid cohesion intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0051760 ! meiotic sister chromatid cohesion, arms relationship: inheres_in GO:0051760 ! meiotic sister chromatid cohesion, arms created_by: midori creation_date: 2015-05-28T11:36:49Z [Term] id: FYPO:0004667 name: normal meiotic sister chromatid cohesion at centromere def: "A cellular process phenotype in which cohesion between sister chromatids is normal (i.e. indistinguishable from wild type) at the centromeric regions during meiosis." [PomBase:mah] synonym: "normal meiotic sister chromatid cohesion, centromeric" EXACT [GO:0051754] synonym: "normal sister chromatid cohesion at centromere during meiosis" EXACT [PomBase:mah] is_a: FYPO:0002094 ! normal meiotic sister chromatid cohesion intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0051754 ! meiotic sister chromatid cohesion, centromeric intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0051754 ! meiotic sister chromatid cohesion, centromeric relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-05-28T11:39:16Z [Term] id: FYPO:0004668 name: premature homologous chromosome segregation def: "A cellular process phenotype in which homologous chromosome segregation begins earlier than normal." [PomBase:mah] synonym: "advanced homologous chromosome segregation" EXACT [PomBase:mah] synonym: "premature chromosome segregation during meiosis I" EXACT [PomBase:mah] is_a: FYPO:0004159 ! abnormal homologous chromosome segregation is_a: PATO:0000694 ! premature intersection_of: PATO:0000694 ! premature intersection_of: inheres_in GO:0045143 ! homologous chromosome segregation relationship: inheres_in GO:0045143 ! homologous chromosome segregation created_by: midori creation_date: 2015-05-28T11:47:12Z [Term] id: FYPO:0004669 name: sensitive to ferrozine def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to ferrozine. Cells stop growing (and may die) at a concentration of ferrozine that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to ferrozine" EXACT [PomBase:mah] synonym: "sensitive to ferrozine during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to ferrozine during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to ferrozine(2-)" EXACT [CHEBI:63945] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:63945 ! ferrozine(2-) relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:63945 ! ferrozine(2-) created_by: midori creation_date: 2015-05-28T12:17:33Z [Term] id: FYPO:0004670 name: abnormal autophagy during nitrogen starvation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which autophagy is abnormal when the cell is subject to nitrogen starvation. Autophagy is the process in which cells digest parts of their own cytoplasm." [GO:0006914, PomBase:mah] synonym: "abnormal autophagy during nitrogen depletion" EXACT [PomBase:mah] synonym: "abnormal autophagy during nitrogen deprivation" EXACT [PomBase:mah] is_a: FYPO:0000163 ! abnormal autophagy intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0006995 ! cellular response to nitrogen starvation intersection_of: inheres_in_part_of GO:0006914 ! autophagy intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0006995 ! cellular response to nitrogen starvation relationship: inheres_in_part_of GO:0006914 ! autophagy relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-05-28T12:26:18Z [Term] id: FYPO:0004671 name: abolished protein localization to vacuole during nitrogen starvation def: "A cell phenotype in which the localization of a protein to the vacuole is abolished when the cell is subject to nitrogen starvation." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to vacuole during nitrogen starvation" EXACT [PomBase:mah] synonym: "abolished protein localization to vacuole during nitrogen depletion" EXACT [PomBase:mah] synonym: "abolished protein localization to vacuole during nitrogen deprivation" EXACT [PomBase:mah] synonym: "protein localization to vacuole abolished during nitrogen starvation" EXACT [PomBase:mah] is_a: FYPO:0001375 ! protein localization abolished intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0006995 ! cellular response to nitrogen starvation intersection_of: towards GO:0072665 ! protein localization to vacuole relationship: during GO:0006995 ! cellular response to nitrogen starvation relationship: towards GO:0072665 ! protein localization to vacuole created_by: midori creation_date: 2015-05-28T12:29:17Z [Term] id: FYPO:0004672 name: inviable elongated vegetative cell with fragmented DNA def: "A cell morphology phenotype in which a vegetatively growing cell is inviable, is longer than normal, and contains DNA broken into small fragments." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "elongated inviable cell with fragmented DNA" EXACT [PomBase:mah] synonym: "inviable elongated cell with fragmented DNA during vegetative growth" EXACT [PomBase:mah] synonym: "inviable elongated vegetative cell with fragmented DNA" EXACT [PomBase:mah, PomBase:vw] synonym: "inviable elongated vegetative cell with fragmented DNA during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001490 ! inviable elongated vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000160 ! fragmented DNA intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000160 ! fragmented DNA relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2015-05-28T13:10:33Z [Term] id: FYPO:0004673 name: inviable elongated multiseptate vegetative cell with fragmented DNA def: "A cell morphology phenotype in which a vegetatively growing cell is inviable, is longer than normal, contains more than one septum, and contains DNA broken into small fragments." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "elongated inviable multiseptate cell with fragmented DNA" EXACT [PomBase:mah] synonym: "inviable elongated multiseptate cell with fragmented DNA during vegetative growth" EXACT [PomBase:mah] synonym: "inviable elongated multiseptate vegetative cell with fragmented DNA during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001493 ! inviable elongated multinucleate vegetative cell is_a: FYPO:0004672 ! inviable elongated vegetative cell with fragmented DNA intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000061 ! multinucleate vegetative cell intersection_of: has_part FYPO:0000160 ! fragmented DNA intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000061 ! multinucleate vegetative cell relationship: has_part FYPO:0000160 ! fragmented DNA relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2015-05-28T13:16:02Z [Term] id: FYPO:0004674 name: sensitive to dimethyl sulfoxide def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to dimethyl sulfoxide. Cells stop growing (and may die) at a concentration of dimethyl sulfoxide that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to dimethyl sulfoxide" EXACT [PomBase:mah] synonym: "sensitive to dimethyl sulfoxide during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to dimethyl sulfoxide during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to dimethyl sulphoxide" EXACT [PomBase:mah] synonym: "sensitive to DMSO" EXACT [CHEBI:28262, PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:28262 ! dimethyl sulfoxide relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:28262 ! dimethyl sulfoxide created_by: midori creation_date: 2015-05-28T13:23:24Z [Term] id: FYPO:0004675 name: normal growth on dimethyl sulfoxide def: "A phenotype in which vegetative cell population growth is normal (i.e. indistinguishable from wild type) in a medium containing dimethyl sulfoxide." [PomBase:mah] synonym: "normal cell population growth in presence of dimethyl sulfoxide" EXACT [PomBase:mah] synonym: "normal cell population growth on dimethyl sulfoxide" EXACT [PomBase:al, PomBase:mah, PomBase:vw] synonym: "normal cell population growth on DMSO" EXACT [CHEBI:28262] synonym: "normal cellular response to dimethyl sulfoxide" RELATED [PomBase:al, PomBase:mah] synonym: "normal growth on dimethyl sulphoxide" EXACT [PomBase:mah] synonym: "normal vegetative cell population growth on dimethyl sulfoxide" EXACT [PomBase:mah] is_a: FYPO:0001357 ! normal vegetative cell population growth intersection_of: FYPO:0001357 ! normal vegetative cell population growth intersection_of: inheres_in BTO:0000316 ! culture medium intersection_of: qualifier PATO:0000467 ! present intersection_of: towards CHEBI:28262 ! dimethyl sulfoxide relationship: inheres_in BTO:0000316 ! culture medium relationship: qualifier PATO:0000467 ! present relationship: towards CHEBI:28262 ! dimethyl sulfoxide created_by: midori creation_date: 2015-05-28T13:25:59Z [Term] id: FYPO:0004676 name: abnormal purine-specific mismatch base pair DNA N-glycosylase activity def: "A molecular function phenotype in which the observed rate of purine-specific mismatch base pair DNA N-glycosylase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0000701 ! purine-specific mismatch base pair DNA N-glycosylase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0000701 ! purine-specific mismatch base pair DNA N-glycosylase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-05-28T13:33:44Z [Term] id: FYPO:0004677 name: abolished purine-specific mismatch base pair DNA N-glycosylase activity def: "A molecular function phenotype in which purine-specific mismatch base pair DNA N-glycosylase activity is absent." [PomBase:mah] synonym: "purine-specific mismatch base pair DNA N-glycosylase activity abolished" EXACT [PomBase:mah] is_a: FYPO:0000664 ! abolished catalytic activity is_a: FYPO:0004676 ! abnormal purine-specific mismatch base pair DNA N-glycosylase activity intersection_of: PATO:0001558 ! lacking processual parts intersection_of: towards GO:0000701 ! purine-specific mismatch base pair DNA N-glycosylase activity relationship: towards GO:0000701 ! purine-specific mismatch base pair DNA N-glycosylase activity created_by: midori creation_date: 2015-05-28T13:33:58Z [Term] id: FYPO:0004678 name: increased polyadenylated 25S rRNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of mature, polyadenylated 25S rRNA measured in a cell is higher than normal." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "increased mature polyadenylated 25S rRNA transcript" EXACT [PomBase:vw] synonym: "increased polyadenylated 25S rRNA accumulation" RELATED [PomBase:mah] synonym: "increased polyadenylated 25S rRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased polyadenylated 25S rRNA level during vegetative growth" EXACT [PomBase:mah] synonym: "increased polyadenylated 25S rRNA transcript level" EXACT [PomBase:vw] is_a: FYPO:0000825 ! increased RNA level during vegetative growth created_by: midori creation_date: 2015-05-28T13:51:41Z [Term] id: FYPO:0004679 name: polyadenylated 25S rRNA absent from cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of polyadenylated 25S rRNA measured in a cell is too low to detect." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "polyadenylated 25S rRNA absent from cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "polyadenylated 25S rRNA absent from cell during vegetative growth" EXACT [PomBase:mah] synonym: "polyadenylated 25S rRNA transcripts absent from cell during vegetative growth" EXACT [PomBase:vw] synonym: "undetectable polyadenylated 25S rRNA level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003161 ! RNA absent from cell during vegetative growth created_by: midori creation_date: 2015-05-28T13:55:12Z [Term] id: FYPO:0004680 name: normal polyadenylated 5.8S rRNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of polyadenylated 5.8S rRNA measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal polyadenylated 5.8S rRNA accumulation" RELATED [PomBase:mah] synonym: "normal polyadenylated 5.8S rRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal polyadenylated 5.8S rRNA level during vegetative growth" EXACT [PomBase:mah] synonym: "normal polyadenylated 5.8S rRNA transcript level" EXACT [PomBase:vw] is_a: FYPO:0001317 ! normal RNA level during vegetative growth created_by: midori creation_date: 2015-05-28T14:19:07Z [Term] id: FYPO:0004681 name: decreased polyadenylated 5.8S rRNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of the mature polyadenylated 5.8S rRNA measured in a cell is lower than normal." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "decreased 5.8S rRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased mature polyadenylated 5.8S rRNA transcript" EXACT [PomBase:vw] synonym: "decreased polyadenylated 5.8S rRNA accumulation" RELATED [PomBase:mah] synonym: "decreased polyadenylated 5.8S rRNA level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased polyadenylated 5.8S rRNA transcript level" EXACT [PomBase:vw] synonym: "reduced polyadenylated 5.8S rRNA level" EXACT [PomBase:mah] is_a: FYPO:0001138 ! decreased 5.8S rRNA level created_by: midori creation_date: 2015-05-28T14:20:04Z [Term] id: FYPO:0004682 name: normal polyadenylated 5S rRNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of polyadenylated 5S rRNA measured in a cell is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal polyadenylated 5S rRNA accumulation" RELATED [PomBase:mah] synonym: "normal polyadenylated 5S rRNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal polyadenylated 5S rRNA level during vegetative growth" EXACT [PomBase:mah] synonym: "normal polyadenylated 5S rRNA transcript level" EXACT [PomBase:vw] is_a: FYPO:0001317 ! normal RNA level during vegetative growth created_by: midori creation_date: 2015-05-28T14:21:38Z [Term] id: FYPO:0004683 name: unequal nucleolus inheritance def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the nucleolus is partitioned to daughter cells unequally during cell division." [PMID:16478992, PomBase:mah] synonym: "unequal mitotic nucleolar partitioning" EXACT [PomBase:al] synonym: "unequal mitotic nucleolar segregation" EXACT [PomBase:al] synonym: "unequal nucleolar inheritance" EXACT [PomBase:mah] synonym: "unequal nucleolus distribution" EXACT [PomBase:mah] synonym: "unequal nucleolus inheritance during mitotic cell cycle" RELATED [PomBase:mah] synonym: "unequal nucleolus inheritance during vegetative growth" EXACT [PomBase:mah] synonym: "unequal nucleolus partitioning" EXACT [PomBase:mah] synonym: "unequal nucleolus segregation" EXACT [PomBase:mah] is_a: FYPO:0001331 ! cellular process phenotype during vegetative growth created_by: midori creation_date: 2015-05-28T14:22:40Z [Term] id: FYPO:0004684 name: inviable elongated binucleate aseptate cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell is inviable, is longer than normal, and has two nuclei but no septum." [PomBase:mah] comment: This phenotype may indicate that the cytokinesis after mitosis checkpoint is activated. synonym: "inviable elongated binucleate aseptate cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable elongated binucleate aseptate vegetative cell" EXACT [PomBase:mah] is_a: FYPO:0002024 ! inviable elongated multinucleate aseptate vegetative cell is_a: FYPO:0004562 ! binucleate aseptate vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000949 ! aseptate intersection_of: has_part FYPO:0001122 ! elongated vegetative cell intersection_of: has_part FYPO:0001222 ! binucleate vegetative cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000949 ! aseptate relationship: has_part FYPO:0001122 ! elongated vegetative cell relationship: has_part FYPO:0001222 ! binucleate vegetative cell relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2015-06-02T13:22:25Z [Term] id: FYPO:0004685 name: sensitive to radicicol def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to radicicol. Cells stop growing (and may die) at a concentration of radicicol that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to radicicol" EXACT [PomBase:mah] synonym: "sensitive to radicicol during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to radicicol during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:556075 ! radicicol relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:556075 ! radicicol created_by: midori creation_date: 2015-06-08T13:48:45Z [Term] id: FYPO:0004686 name: sensitive to streptothricin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to streptothricin. Cells stop growing (and may die) at a concentration of streptothricin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to streptothricin" EXACT [PomBase:mah] synonym: "sensitive to streptothricin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to streptothricin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:26789 ! streptothricin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:26789 ! streptothricin created_by: midori creation_date: 2015-06-08T13:50:14Z [Term] id: FYPO:0004687 name: sensitive to lovastatin def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to lovastatin. Cells stop growing (and may die) at a concentration of lovastatin that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to lovastatin" EXACT [PomBase:mah] synonym: "sensitive to lovastatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to lovastatin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:40303 ! lovastatin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:40303 ! lovastatin created_by: midori creation_date: 2015-06-08T13:50:58Z [Term] id: FYPO:0004688 name: decreased cytosolic large ribosomal subunit level def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells contain fewer free large ribosomal subunits in the cytosol than normal." [PomBase:mah] synonym: "cytosolic large ribosomal subunit present at decreased level" EXACT [PomBase:mah] synonym: "decreased 60S ribosomal subunit level" EXACT [PomBase:mah] synonym: "decreased cytosolic large ribosomal subunit level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cytosolic large ribosomal subunit level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased large ribosomal subunit level" BROAD [PomBase:mah] synonym: "decreased level of cytosolic large ribosomal subunits" RELATED [PomBase:al] synonym: "reduced cytosolic large ribosomal subunit level" EXACT [PomBase:mah] is_a: FYPO:0003684 ! altered level of macromolecular complex is_a: PATO:0002001 ! has fewer parts of type intersection_of: PATO:0002001 ! has fewer parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0022625 ! cytosolic large ribosomal subunit relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0022625 ! cytosolic large ribosomal subunit created_by: midori creation_date: 2015-06-08T13:59:13Z [Term] id: FYPO:0004689 name: increased cenH-derived RNA level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA transcribed from cenH measured in a cell is higher than normal. cenH is a region located between mat2-P and mat3-M that is homologous to centromeric repeats, and that produces non-coding RNAs and small interfering RNAs." [PMID:21253571, PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "accumulation of cenH-derived RNA transcripts" RELATED [PomBase:vw] synonym: "increased cenH RNA level" EXACT [PomBase:al] synonym: "increased cenH-derived RNA accumulation" RELATED [PomBase:mah] synonym: "increased cenH-derived RNA level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cenH-derived RNA level during vegetative growth" EXACT [PomBase:mah] synonym: "increased cenH-derived RNA transcript level" EXACT [PomBase:vw] is_a: FYPO:0000825 ! increased RNA level during vegetative growth created_by: midori creation_date: 2015-06-09T10:59:17Z [Term] id: FYPO:0004690 name: increased histone H3-K9 acetylation at silent mating-type cassette def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which acetylation of lysine at position 9 of histone H3 at the silent mating-type cassettes occurs to a greater extent than normal." [PomBase:mah] synonym: "increased histone H3-K9 acetylation at silent mating-type cassette during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone H3-K9 acetylation at silent mating-type cassette during vegetative growth" EXACT [PomBase:mah] synonym: "increased histone H3K9 acetylation at silent mating-type cassette" EXACT [GO:0043970, PomBase:mah] is_a: FYPO:0000892 ! increased histone H3-K9 acetylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0043970 ! histone H3-K9 acetylation intersection_of: occurs_at SO:0001984 ! silent_mating_type_cassette_array relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0043970 ! histone H3-K9 acetylation relationship: occurs_at SO:0001984 ! silent_mating_type_cassette_array created_by: midori creation_date: 2015-06-09T11:01:24Z [Term] id: FYPO:0004691 name: inviable swollen spherical vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is inviable, is shaped in the form of a sphere, and has a larger volume than normal. In a swollen cell, both length and diameter are greater than normal, although the cell is only considered elongated if the length:width ratio is also greater than normal." [PomBase:mah] synonym: "essential; swollen spherical vegetative cell" RELATED [PomBase:mah] synonym: "inviable enlarged spherical vegetative cell" RELATED [PomBase:mah] synonym: "inviable enlarged volume spherical vegetative cell" EXACT [PomBase:mah] synonym: "inviable large spherical vegetative cell" RELATED [PomBase:vw] synonym: "inviable swollen spherical cell during vegetative growth" EXACT [PomBase:mah] synonym: "inviable swollen spherical vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "inviable, increased spherical vegetative cell size" RELATED [PomBase:vw] synonym: "inviable, increased spherical vegetative cell volume" EXACT [PomBase:mah] is_a: FYPO:0000947 ! swollen spherical vegetative cell is_a: FYPO:0002190 ! inviable swollen spheroid vegetative cell is_a: FYPO:0004104 ! inviable spherical vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000025 ! swollen cell intersection_of: has_part FYPO:0000129 ! spherical vegetative cell intersection_of: has_part FYPO:0001489 ! inviable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000025 ! swollen cell relationship: has_part FYPO:0000129 ! spherical vegetative cell relationship: has_part FYPO:0001489 ! inviable vegetative cell created_by: midori creation_date: 2015-06-09T11:16:29Z [Term] id: FYPO:0004692 name: normal protein localization to mitotic spindle midzone def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the mitotic spindle midzone is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to mitotic spindle midzone" EXACT [PomBase:mah] synonym: "normal protein localization to mitotic spindle midzone during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002966 ! normal protein localization to mitotic spindle intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902967 ! protein localization to mitotic spindle midzone intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902967 ! protein localization to mitotic spindle midzone relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-06-09T11:32:39Z [Term] id: FYPO:0004693 name: normal viability following cellular response to hydroxyurea def: "A cell population phenotype in which a normal proportion of the population remains viable after exposure to hydroxyurea." [PomBase:mah] synonym: "normal cell population viability following cellular response to hydroxyurea" EXACT [PomBase:mah] synonym: "normal viability following cellular response to HU" EXACT [PomBase:mah] synonym: "normal viability following HU exposure" EXACT [PomBase:mah] is_a: FYPO:0000257 ! normal phenotype is_a: FYPO:0002057 ! cell population viability created_by: midori creation_date: 2015-06-09T15:08:04Z [Term] id: FYPO:0004694 name: fragmented DNA during stationary phase def: "A cell phenotype in which DNA is broken into small fragments when the population in which the cell is found is in stationary phase." [PMID:12963726, PomBase:mah] comment: This term can be used for any circumstances in which cells are starved for nitrogen. Note that cells may enter G0 (quiescence) when subjected to prolonged nitrogen starvation; this term is not restricted to G0. synonym: "DNA fragmentation during stationary phase" EXACT [PomBase:mah] is_a: FYPO:0000160 ! fragmented DNA created_by: midori creation_date: 2015-06-12T13:45:52Z [Term] id: FYPO:0004695 name: increased cellular diglyceride level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more diglycerides measured in a cell is higher than normal." [PomBase:mah] synonym: "increased cellular DAG level" EXACT [PomBase:mah] synonym: "increased cellular diacylglycerol level" EXACT [CHEBI:18035] synonym: "increased cellular diglyceride level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cellular diglyceride level during vegetative growth" EXACT [PomBase:mah] synonym: "increased diglyceride accumulation" RELATED [PomBase:mah] is_a: FYPO:0001330 ! increased level of substance in cell during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:18035 ! diglyceride relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:18035 ! diglyceride created_by: midori creation_date: 2015-06-12T13:52:54Z [Term] id: FYPO:0004696 name: sensitive to fatty acid def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to one or more fatty acids (usually supplied as the corresponding anions). Cells stop growing (and may die) at a concentration of fatty acid that allows wild type cells to grow." [PMID:12963726, PomBase:mah] synonym: "hypersensitive to fatty acid" EXACT [PomBase:mah] synonym: "sensitive to fatty acid anion" EXACT [CHEBI:28868, CHEBI:35366] synonym: "sensitive to fatty acid during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to fatty acid during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to free fatty acids" EXACT [PomBase:al] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth intersection_of: PATO:0001551 ! increased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:28868 ! fatty acid anion relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:28868 ! fatty acid anion created_by: midori creation_date: 2015-06-12T14:33:27Z [Term] id: FYPO:0004697 name: sensitive to 1,2-dioctanoyl-sn-glycerol def: "A phenotype observed in the vegetative growth phase of the life cycle in which cells show increased sensitivity to 1,2-dioctanoyl-sn-glycerol (DiC8 DAG). Cells stop growing (and may die) at a concentration of 1,2-dioctanoyl-sn-glycerol that allows wild type cells to grow." [PomBase:mah] synonym: "hypersensitive to 1,2-dioctanoyl-sn-glycerol" EXACT [PomBase:mah] synonym: "sensitive to 1,2-dioctanoyl-sn-glycerol during mitotic cell cycle" RELATED [PomBase:mah] synonym: "sensitive to 1,2-dioctanoyl-sn-glycerol during vegetative growth" EXACT [PomBase:mah] synonym: "sensitive to DiC8 DAG" EXACT [PMID:12963726] is_a: FYPO:0000127 ! increased sensitivity to chemical during vegetative growth created_by: midori creation_date: 2015-06-12T14:54:29Z [Term] id: FYPO:0004698 name: decreased heme binding def: "A molecular function phenotype in which occurrence of heme binding by a gene product (usually a protein) in a mutant is decreased. The affected gene product may be encoded by the mutated gene, or by a different gene." [PomBase:mah] comment: This term can mean that the mutated gene product itself binds heme more than wild type, or that a mutation in one gene increases heme binding by a second gene product. When using this term, it is therefore recommended to note the specific protein(s) affected. synonym: "decreased haem binding" EXACT [PomBase:mah] is_a: FYPO:0000707 ! abnormal molecular function is_a: FYPO:0001092 ! binding phenotype is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0020037 ! heme binding relationship: inheres_in GO:0020037 ! heme binding created_by: midori creation_date: 2015-06-12T15:05:16Z [Term] id: FYPO:0004699 name: monoseptate vegetative cell with binucleate and anucleate compartments def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell has two nuclei and one septum, but both nuclei are in a single compartment on one side of the septum." [PomBase:mah] synonym: "binucleate monoseptate cell with nuclei grouped" RELATED [PomBase:al] synonym: "monoseptate cell with binucleate and anucleate compartments during vegetative growth" EXACT [PomBase:mah] synonym: "monoseptate vegetative cell with binucleate and anucleate compartments during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001225 ! monoseptate relationship: has_part FYPO:0002071 ! mislocalized nucleus during vegetative growth created_by: midori creation_date: 2015-07-08T16:07:58Z [Term] id: FYPO:0004700 name: bent vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which a cell is bent along the long axis. In a bent cell, the long axis has one or more angles, rather than following a straight line." [PomBase:mah] synonym: "bent cell" EXACT [PomBase:mah] synonym: "bent cell during vegetative growth" EXACT [PomBase:mah] synonym: "bent vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "cell morphology, bent" EXACT [PomBase:mah] is_a: FYPO:0002196 ! abnormal vegetative cell shape is_a: PATO:0000617 ! bent intersection_of: PATO:0000617 ! bent intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) created_by: midori creation_date: 2015-07-08T16:24:25Z [Term] id: FYPO:0004701 name: abolished cell division timing change upon nitrogen source shift def: "A phenotype in which a cell does not alter the timing or rate of cell division when shifted from one nitrogen source to another. Normally, cell division is delayed upon shifting from a poor to a rich nitrogen source, and accelerated upon shifting from a rich to a poor nitrogen source." [PMID:689088, PMID:872891, PomBase:mah] comment: This phenotype is typically observed at the population level. synonym: "abolished cell division rate change upon nitrogen source shift" RELATED [PomBase:mah] synonym: "abolished change in cell division rate upon nitrogen source shift" RELATED [PomBase:mah] synonym: "abolished change in cell division timing upon nitrogen source shift" EXACT [PomBase:mah] synonym: "abolished nutritional modulation of cell division" RELATED [PomBase:mah] synonym: "unchanged cell division timing upon nitrogen source shift" RELATED [PomBase:mah] is_a: FYPO:0000003 ! cell population phenotype created_by: midori creation_date: 2015-07-10T14:37:09Z [Term] id: FYPO:0004702 name: cytoplasmic microtubules absent from cell def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the cell does not contain detectable cytoplasmic microtubules." [PomBase:mah] synonym: "absent cytoplasmic microtubules" EXACT [PomBase:mah] synonym: "cytoplasmic microtubules absent from cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "cytoplasmic microtubules absent from cell during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0002004 ! microtubules absent from cell intersection_of: PATO:0002000 ! lacks all parts of type intersection_of: inheres_in CL:0000000 ! cell intersection_of: towards GO:0005881 ! cytoplasmic microtubule relationship: inheres_in CL:0000000 ! cell relationship: towards GO:0005881 ! cytoplasmic microtubule created_by: midori creation_date: 2015-07-10T14:49:27Z [Term] id: FYPO:0004703 name: viable curved, elongated, swollen vegetative cell def: "A cell morphology phenotype in which a vegetatively growing cell is viable, is longer and has a larger volume than normal, and is curved along the long axis. In a curved cell, the long axis follows a smooth bend rather than a straight line." [PomBase:mah] comment: Note that if you have done an experiment that assays the viability of a population of cells, such as looking at colony growth or growth in liquid culture, you should also annotate to 'viable cell population' (FYPO:0002058) or one of its descendants. synonym: "curved elongated swollen viable cell" EXACT [PomBase:mah] synonym: "viable curved swollen elongated cell" EXACT [PomBase:mah] synonym: "viable curved, elongated, swollen cell during vegetative growth" EXACT [PomBase:mah] synonym: "viable curved, elongated, swollen vegetative cell during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0002215 ! viable curved elongated vegetative cell is_a: FYPO:0002402 ! viable swollen vegetative cell with abnormal cell shape is_a: FYPO:0002479 ! viable swollen elongated vegetative cell intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000016 ! curved vegetative cell intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0000025 ! swollen cell intersection_of: has_part FYPO:0001491 ! viable vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000016 ! curved vegetative cell relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0000025 ! swollen cell relationship: has_part FYPO:0001491 ! viable vegetative cell created_by: midori creation_date: 2015-07-10T15:04:39Z [Term] id: FYPO:0004704 name: cytoplasmic microtubules present in greater numbers def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells contain more cytoplasmic microtubules than normal." [PomBase:mah] synonym: "cytoplasmic microtubules present in increased numbers" EXACT [PomBase:mah] synonym: "increased level of cytoplasmic MTs" EXACT [PomBase:mah] is_a: FYPO:0004538 ! microtubules present in greater numbers intersection_of: PATO:0002002 ! has extra parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0005881 ! cytoplasmic microtubule relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0005881 ! cytoplasmic microtubule created_by: midori creation_date: 2015-07-10T15:07:06Z [Term] id: FYPO:0004705 name: delayed mitotic sister chromatid separation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitotic sister chromatid separation begins later than normal." [PomBase:mah] synonym: "delayed mitotic sister chromatid separation during vegetative growth" EXACT [PomBase:mah] synonym: "delayed sister chromatid separation during mitosis" EXACT [PomBase:mah] is_a: FYPO:0000670 ! abnormal mitotic sister chromatid separation is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0051306 ! mitotic sister chromatid separation relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0051306 ! mitotic sister chromatid separation created_by: midori creation_date: 2015-07-10T15:10:03Z [Term] id: FYPO:0004706 name: decreased cytosolic monomeric ribosome level def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells contain fewer monomeric ribosomes (80S monosomes) in the cytosol than normal." [PMID:26122634, PomBase:mah] synonym: "cytosolic monomeric ribosomes present at decreased level" EXACT [PomBase:mah] synonym: "decreased cytosolic 80S monosome level" EXACT [PomBase:mah] synonym: "decreased cytosolic monomeric 80S ribosome level" EXACT [PomBase:mah] synonym: "decreased cytosolic monomeric ribosome level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cytosolic monomeric ribosome level during vegetative growth" EXACT [PomBase:mah] synonym: "decreased cytosolic ribosome level" BROAD [PomBase:mah] synonym: "decreased level of cytosolic monomeric ribosomes" EXACT [PomBase:al] synonym: "reduced cytosolic monomeric ribosome level" EXACT [PomBase:mah] is_a: FYPO:0003684 ! altered level of macromolecular complex created_by: midori creation_date: 2015-07-10T15:17:13Z [Term] id: FYPO:0004707 name: increased cytosolic half-mer polysome level def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells contain more half-mer polysomes in the cytosol than normal. A half-mer polysome is a complex consisting of an mRNA bound to a single small ribosomal subunit, followed by one or more complete bound ribosomes." [PMID:18611858, PMID:19806183, PMID:26122634, PomBase:mah] synonym: "cytosolic half-mer polysomes present at increased level" EXACT [PomBase:mah] synonym: "increased cytosolic half-mer polysome level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased cytosolic half-mer polysome level during vegetative growth" EXACT [PomBase:mah] synonym: "increased cytosolic halfmer polysome level" EXACT [PomBase:mah] synonym: "increased level of cytosolic half-mer polysomes" RELATED [PomBase:al] is_a: FYPO:0003684 ! altered level of macromolecular complex created_by: midori creation_date: 2015-07-10T15:20:10Z [Term] id: FYPO:0004708 name: decreased cytosolic large:small ribosomal subunit ratio def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the ratio of large to small ribosomal subunits present in the cytosol is lower than normal.." [PMID:26122634, PomBase:mah] synonym: "decreased 60S:40S cytosolic ribosomal subunit ratio" EXACT [PomBase:mah] synonym: "decreased cytosolic 60S:40S ribosomal subunit ratio" EXACT [PomBase:mah] synonym: "decreased cytosolic large:small ribosomal subunit ratio during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased cytosolic large:small ribosomal subunit ratio during vegetative growth" EXACT [PomBase:mah] synonym: "decreased cytosolic ribosomal large:small subunit ratio" EXACT [PomBase:mah] synonym: "reduced cytosolic large:small ribosomal subunit ratio" EXACT [PomBase:mah] is_a: FYPO:0004638 ! abnormal cellular physical quality phenotype created_by: midori creation_date: 2015-07-10T15:23:17Z [Term] id: FYPO:0004709 name: increased number of Rad52 foci def: "A cell phenotype in which the number of sites at which the protein Rad52 (also called Rad22) accumulates is greater than normal." [PMID:22064477, PomBase:mah] comment: Because Rad22 often accumulates at double-strand breaks, consider also annotating to 'accumulation of double-strand break sites' (FYPO:0000455). synonym: "increased number of Rad22 foci" EXACT [PomBase:mah] is_a: FYPO:0000136 ! cellular physical quality phenotype created_by: midori creation_date: 2015-07-14T11:51:29Z [Term] id: FYPO:0004710 name: increased number of Rad52 foci during G0 to G1 transition def: "A cell phenotype observed when the cell undergoes transition from G0 phase to G1 in which the number of sites at which the protein Rad52 (also called Rad22) accumulates is greater than normal." [PMID:19197239, PomBase:mah] comment: Because Rad22 often accumulates at double-strand breaks, consider also annotating to 'accumulation of double-strand break sites' (FYPO:0000455). synonym: "increased number of Rad22 foci during G0 to G1 transition" EXACT [PomBase:mah] synonym: "increased number of Rad52 foci during cell cycle re-entry" EXACT [PomBase:mah] synonym: "increased number of Rad52 foci during cell quiescence to G1 transition" EXACT [PomBase:mah] synonym: "increased number of Rad52 foci during exit from cell quiescence" EXACT [PomBase:mah] synonym: "increased number of Rad52 foci during quiescence to G1 transition" EXACT [PomBase:mah] is_a: FYPO:0004709 ! increased number of Rad52 foci created_by: midori creation_date: 2015-07-14T12:03:46Z [Term] id: FYPO:0004711 name: decreased level of translation gene RNA during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more translation RNAs measured in a cell is lower than normal (i.e. lower than observed in wild-type cells). Translation RNAs are transcribed from genes whose products are involved in translation." [PMID:18203864, PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "decreased level of translation gene RNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased level of translation gene transcripts during vegetative growth" EXACT [PomBase:vw] synonym: "decreased translation gene RNA accumulation during vegetative growth" RELATED [PomBase:mah] synonym: "reduced level of translation gene RNA during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth created_by: midori creation_date: 2015-07-15T15:27:26Z [Term] id: FYPO:0004712 name: decreased level of nucleotide metabolism gene RNA during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more nucleotide metabolism RNAs measured in a cell is lower than normal (i.e. lower than observed in wild-type cells). Nucleotide metabolism RNAs are transcribed from genes whose products are involved in any nucleotide metabolic process." [PMID:18203864, PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "decreased level of nucleotide metabolism gene RNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased level of nucleotide metabolism gene transcripts during vegetative growth" EXACT [PomBase:vw] synonym: "decreased nucleotide metabolism gene RNA accumulation during vegetative growth" RELATED [PomBase:mah] synonym: "reduced level of nucleotide metabolism gene RNA during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth created_by: midori creation_date: 2015-07-15T15:29:26Z [Term] id: FYPO:0004713 name: decreased level of amino acid biosynthesis gene RNA during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more amino acid biosynthesis RNAs measured in a cell is lower than normal (i.e. lower than observed in wild-type cells). Amino acid biosynthesis RNAs are transcribed from genes whose products are involved in amino acid biosynthetic processes." [PMID:18203864, PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "decreased amino acid biosynthesis gene RNA accumulation during vegetative growth" RELATED [PomBase:mah] synonym: "decreased level of amino acid biosynthesis gene RNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased level of amino acid biosynthesis gene transcripts during vegetative growth" EXACT [PomBase:vw] synonym: "reduced level of amino acid biosynthesis gene RNA during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth created_by: midori creation_date: 2015-07-15T15:45:30Z [Term] id: FYPO:0004714 name: decreased level of amino acid import gene RNA during vegetative growth def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of one or more amino acid import RNAs measured in a cell is lower than normal (i.e. lower than observed in wild-type cells). Amino acid import RNAs are transcribed from genes whose products are involved in amino acid import into the cell or an organelle." [PMID:18203864, PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. synonym: "decreased amino acid import gene RNA accumulation during vegetative growth" RELATED [PomBase:mah] synonym: "decreased level of amino acid import gene RNA during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased level of amino acid import gene transcripts during vegetative growth" EXACT [PomBase:vw] synonym: "reduced level of amino acid import gene RNA during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001117 ! decreased RNA level during vegetative growth created_by: midori creation_date: 2015-07-15T15:46:19Z [Term] id: FYPO:0004715 name: large vacuoles present in decreased numbers during salt stress def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a cell contains fewer, but larger, vacuoles than normal when the cell is subject to salt stress." [PomBase:mah] synonym: "enlarged vacuoles present in decreased numbers during salt stress" EXACT [PomBase:mah] synonym: "large vacuoles present in decreased numbers during salt stress during mitotic cell cycle" RELATED [PomBase:mah] synonym: "large vacuoles present in decreased numbers during salt stress during vegetative growth" EXACT [PomBase:mah] synonym: "large vacuoles present in reduced numbers during salt stress" EXACT [PomBase:mah] is_a: FYPO:0002795 ! large vacuoles present in decreased numbers during vegetative growth intersection_of: FYPO:0004638 ! abnormal cellular physical quality phenotype intersection_of: exists_during GO:0071472 ! cellular response to salt stress intersection_of: has_part FYPO:0000123 ! large vacuoles during vegetative growth intersection_of: has_part FYPO:0002793 ! vacuoles present in decreased numbers during vegetative growth relationship: exists_during GO:0071472 ! cellular response to salt stress relationship: has_part FYPO:0000123 ! large vacuoles during vegetative growth relationship: has_part FYPO:0002793 ! vacuoles present in decreased numbers during vegetative growth created_by: midori creation_date: 2015-07-15T15:49:58Z [Term] id: FYPO:0004716 name: decreased protein localization to telomeric heterochromatin during horsetail movement def: "A cell phenotype in which the localization of a protein to heterochromatin at telomeres is decreased during the part of meiotic prophase I in which horsetail nuclear movement takes place." [PMID:11676925, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to heterochromatin at telomere during horsetail movement" EXACT [PomBase:mah] synonym: "decreased protein localization to heterochromatin at telomere during horsetail movement" EXACT [PomBase:mah] synonym: "decreased protein localization to heterochromatin at telomere during horsetail nuclear movement" EXACT [GO:0030989] synonym: "decreased protein localization to telomeric heterochromatin during dynein-driven meiotic oscillatory nuclear movement" EXACT [GO:0030989] synonym: "decreased protein localization to telomeric heterochromatin during meiotic horsetail phase" RELATED [PomBase:al] synonym: "reduced protein localization to heterochromatin at telomere during horsetail movement" EXACT [PomBase:mah] is_a: FYPO:0004717 ! abnormal protein localization to heterochromatin during meiosis is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0030989 ! dynein-driven meiotic oscillatory nuclear movement intersection_of: inheres_in GO:1990152 ! protein localization to telomeric heterochromatin relationship: happens_during GO:0030989 ! dynein-driven meiotic oscillatory nuclear movement relationship: inheres_in GO:1990152 ! protein localization to telomeric heterochromatin created_by: midori creation_date: 2015-07-20T15:28:12Z [Term] id: FYPO:0004717 name: abnormal protein localization to heterochromatin during meiosis def: "A cell phenotype in which the localization of a protein to heterochromatin is abnormal during one or both meiotic nuclear divisions." [PomBase:mah] comment: Encompasses both presence of proteins not normally found associated with heterochromatin and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to heterochromatin during meiosis" EXACT [PomBase:mah] synonym: "abnormal protein localization to heterochromatin during meiotic nuclear division" EXACT [GO:0007126] is_a: FYPO:0003549 ! abnormal protein localization during meiosis is_a: FYPO:0004718 ! abnormal protein localization to heterochromatin intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0007126 ! meiotic nuclear division intersection_of: inheres_in_part_of GO:0097355 ! protein localization to heterochromatin intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0007126 ! meiotic nuclear division relationship: inheres_in_part_of GO:0097355 ! protein localization to heterochromatin relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-07-20T15:30:34Z [Term] id: FYPO:0004718 name: abnormal protein localization to heterochromatin def: "A cell phenotype in which the localization of a protein to heterochromatin is abnormal." [PomBase:mah] comment: Encompasses both presence of proteins not normally found associated with heterochromatin and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to heterochromatin" EXACT [PomBase:mah] is_a: FYPO:0001679 ! abnormal protein localization to chromatin intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0097355 ! protein localization to heterochromatin intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0097355 ! protein localization to heterochromatin relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-07-20T15:32:11Z [Term] id: FYPO:0004719 name: abnormal mitotic cell cycle arrest with condensed chromosomes, septated cell def: "A cellular process phenotype in which progression through the mitotic cell cycle is arrested when cells have condensed chromosomes and a single, normally located septum, under conditions where arrest does not normally occur." [PMID:8387358, PomBase:al, PomBase:mah] comment: In wild-type cells, chromosomes are condensed only in M phase. This term can be used for mutants in which chromosomes are condensed but other normal features of M phase cells are not observed. synonym: "abnormal mitotic cell cycle arrest with condensed chromosomes, septated cell during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal mitotic cell cycle arrest with condensed chromosomes, septated vegetative cell" EXACT [PomBase:mah] is_a: FYPO:0003738 ! abnormal mitotic cell cycle arrest with condensed chromosomes created_by: midori creation_date: 2015-07-20T16:00:02Z [Term] id: FYPO:0004720 name: normal viability following cellular response to heat shock def: "A cell population phenotype in which a normal proportion of the population remains viable after exposure to heat shock. Heat shock is a form of heat stress in which cells are briefly exposed to a very high temperature." [PMID:11711540, PomBase:mah] synonym: "normal cell population viability following heat shock" EXACT [PomBase:mah] is_a: FYPO:0000257 ! normal phenotype is_a: FYPO:0002057 ! cell population viability created_by: midori creation_date: 2015-07-20T16:10:01Z [Term] id: FYPO:0004721 name: decreased rate of microtubule depolymerization at minus end def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which minus-end specific microtubule depolymerization, i.e. the removal of tubulin dimers from the minus end of a microtubule, occurs at a lower rate, or speed, than normal." [GO:0036078, PomBase:mah] synonym: "decreased microtubule depolymerization rate at minus end" EXACT [PomBase:mah] synonym: "decreased microtubule minus end shrinkage" RELATED [PomBase:vw] synonym: "decreased rate of microtubule depolymerization at minus end during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased rate of microtubule depolymerization at minus end during vegetative growth" EXACT [PomBase:mah] synonym: "decreased rate of minus-end specific microtubule depolymerization" EXACT [GO:0036078] synonym: "increased microtubule stability" RELATED [PomBase:vw] synonym: "reduced rate of microtubule depolymerization at minus end" EXACT [PomBase:mah] is_a: FYPO:0000903 ! decreased rate of microtubule depolymerization intersection_of: PATO:0000911 ! decreased rate intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0036078 ! minus-end specific microtubule depolymerization relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0036078 ! minus-end specific microtubule depolymerization created_by: midori creation_date: 2015-07-27T11:56:31Z [Term] id: FYPO:0004722 name: normal nuclear microtubules def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the morphology of nuclear microtubules is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal nuclear microtubule morphology" EXACT [PomBase:al] synonym: "normal nuclear microtubule structure" NARROW [PomBase:mah] synonym: "normal nuclear microtubules during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal nuclear microtubules during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001313 ! normal subcellular component during vegetative growth is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005880 ! nuclear microtubule intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005880 ! nuclear microtubule relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-07-27T12:06:15Z [Term] id: FYPO:0004723 name: transiently misoriented mitotic spindle def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the mitotic spindle is assembled in an incorrect orientation. Spindle orientation is later corrected so that the spindle is parallel to the long axis of the cell." [PMID:15772152, PomBase:mah] comment: In wild-type cells, the spindle is initially misoriented in a small number of cells (typically around 8% of a cell population). Use this term if the frequency of spindle misorientation is increased above the wild-type occurrence. synonym: "transient abnormal mitotic spindle orientation" EXACT [PomBase:mah] synonym: "transient mitotic spindle misorientation" EXACT [PomBase:mah] synonym: "transiently misoriented mitotic spindle during vegetative growth" EXACT [PomBase:mah] synonym: "transiently misoriented spindle during mitotic cell cycle" EXACT [PomBase:mah] is_a: FYPO:0000338 ! abnormal mitotic spindle created_by: midori creation_date: 2015-07-27T12:29:27Z [Term] id: FYPO:0004724 name: long nuclear microtubules protruding through nuclear envelope during interphase def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells form nuclear microtubules during interphase of the mitotic cell cycle that are longer than normal, and are partially or completely surrounded by an extension of the nuclear envelope. These microtubules usually have one end in close proximity to a spindle pole body, and may puncture the nuclear envelope to extent into the cytoplasm." [PMID:15772152, PomBase:mah] synonym: "long nuclear microtubules during interphase, with nuclear envelope protrusion" EXACT [PomBase:vw] synonym: "long nuclear microtubules protruding through nuclear envelope at interphase" EXACT [PomBase:vw] synonym: "long nuclear microtubules protruding through nuclear envelope during interphase during mitotic cell cycle" RELATED [PomBase:mah] synonym: "long nuclear microtubules protruding through nuclear envelope during interphase during vegetative growth" EXACT [PomBase:mah] synonym: "long nuclear microtubules protruding through nuclear envelope during mitotic interphase" EXACT [PomBase:vw] synonym: "nuclear envelope protrusion with long mitotic spindle microtubules protruding beyond spindle pole body" EXACT [PomBase:vw] is_a: FYPO:0000055 ! long microtubules relationship: has_part FYPO:0004725 ! nuclear envelope protrusion present during interphase created_by: midori creation_date: 2015-07-27T12:51:58Z [Term] id: FYPO:0004725 name: nuclear envelope protrusion present during interphase def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the nuclear envelope has one or more extensions that protrude into the cytoplasm during interphase of the mitotic cell cycle." [PMID:15772152, PomBase:mah] comment: This term differs from 'lobate nuclear envelope' (FYPO:0002005) in that a lobate envelope has a few deep fissures extending inward from the cytoplasm that appear to partially divide the nucleus into portions, whereas protrusions are smaller and extend outward from the bulk of the nucleus. synonym: "nuclear envelope protrusion present during interphase during mitotic cell cycle" RELATED [PomBase:mah] synonym: "nuclear envelope protrusion present during interphase during vegetative growth" EXACT [PomBase:mah] synonym: "nuclear envelope protrusion present during mitotic interphase" EXACT [PomBase:mah] synonym: "protruding nuclear envelope during mitotic interphase" EXACT [PomBase:mah] is_a: FYPO:0000769 ! abnormal nuclear envelope morphology during vegetative growth is_a: PATO:0001598 ! protruding intersection_of: PATO:0001598 ! protruding intersection_of: exists_during GO:0051329 ! mitotic interphase intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005635 ! nuclear envelope relationship: exists_during GO:0051329 ! mitotic interphase relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005635 ! nuclear envelope created_by: midori creation_date: 2015-07-27T12:52:58Z [Term] id: FYPO:0004726 name: normal mitotic spindle orientation correction def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which mitotic spindle orientation correction is normal (i.e. indistinguishable from wild type). Spindle orientation correction is the process by which a spindle that has formed in, or moved into, an incorrect orientation is restored to the correct orientation (parallel to the long axis of the cell)." [PMID:15772152, PomBase:mah] comment: The mitotic spindle may form in an incorrect orientation infrequently in wild-type cells, or at a higher frequency in some mutants. Use this term for mutants in which the process of correcting the orientation of a misoriented spindle is the same as wild type, even if the initial misorientation occurs more frequently than in wild type. synonym: "normal correction of mitotic spindle orientation" EXACT [PomBase:mah] synonym: "normal mitotic spindle orientation correction during vegetative growth" EXACT [PomBase:mah] synonym: "normal spindle orientation correction during mitosis" EXACT [PomBase:mah] is_a: FYPO:0001319 ! normal cellular process during vegetative growth created_by: midori creation_date: 2015-07-27T13:11:51Z [Term] id: FYPO:0004727 name: cytoplasmic microtubule formation from nuclear microtubules def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which cytoplasmic microtubules are formed from existing nuclear microtubules. Normally, cytoplasmic microtubules are nucleated from microtubule organizing centers in the cytoplasm." [PMID:15772152, PomBase:mah] synonym: "cytoplasmic microtubule formation from nuclear microtubules during mitotic cell cycle" RELATED [PomBase:mah] synonym: "cytoplasmic microtubule formation from nuclear microtubules during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001350 ! abnormal microtubule cytoskeleton organization during vegetative growth created_by: midori creation_date: 2015-07-27T13:32:05Z [Term] id: FYPO:0004728 name: cytoplasmic microtubule formation from nuclear microtubules following nuclear envelope breakthrough def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which cytoplasmic microtubules are formed by the extension of existing nuclear microtubules through a puncture in the nuclear envelope. Normally, cytoplasmic microtubules are nucleated from microtubule organizing centers in the cytoplasm." [PMID:15772152, PomBase:mah] comment: Also see 'long nuclear microtubules protruding through nuclear envelope during interphase' (FYPO:0004724). synonym: "cytoplasmic microtubule formation from nuclear microtubules following nuclear envelope breakthrough during mitotic cell cycle" RELATED [PomBase:mah] synonym: "cytoplasmic microtubule formation from nuclear microtubules following nuclear envelope breakthrough during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0004727 ! cytoplasmic microtubule formation from nuclear microtubules created_by: midori creation_date: 2015-07-27T13:38:44Z [Term] id: FYPO:0004729 name: cytoplasmic microtubule formation from nuclear microtubules following spindle microtubule fragmentation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which cytoplasmic microtubules are formed by the extension of existing nuclear microtubules arising from fragmentation of the mitotic spindle. Normally, cytoplasmic microtubules are nucleated from microtubule organizing centers in the cytoplasm." [PMID:15772152, PomBase:mah] synonym: "cytoplasmic microtubule formation from nuclear microtubules following mitotic spindle microtubule fragmentation" EXACT [PomBase:mah] synonym: "cytoplasmic microtubule formation from nuclear microtubules following spindle microtubule fragmentation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "cytoplasmic microtubule formation from nuclear microtubules following spindle microtubule fragmentation during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0004727 ! cytoplasmic microtubule formation from nuclear microtubules created_by: midori creation_date: 2015-07-27T13:40:38Z [Term] id: FYPO:0004730 name: protein mislocalized to lateral cell cortex def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which a protein that is not normally found at the lateral cell cortex is observed there. The lateral cell cortex is the region directly beneath the plasma membrane of the lateral portion of the cell." [GO:0097575, PomBase:mah] comment: Note that this term can be used to annotate any case where a protein is found in the lateral cell cortex in a mutant, but not in wild type. In some cases, there may be enough additional information to annotate to 'abnormal protein localization' (FYPO:0000443) or one of its descendants. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "ectopic protein localization to lateral cell cortex" EXACT [PomBase:vw] synonym: "protein mislocalised to lateral cell cortex" EXACT [PomBase:mah] synonym: "protein mislocalised to lateral cell cortex during vegetative growth" EXACT [PomBase:mah] synonym: "protein mislocalized to cell side during vegetative growth" RELATED [PomBase:vw] synonym: "protein mislocalized to lateral cell cortex during mitotic cell cycle" RELATED [PomBase:mah] synonym: "protein mislocalized to lateral cell cortex during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000782 ! mislocalized protein during vegetative growth intersection_of: PATO:0000628 ! mislocalised intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CHEBI:36080 ! protein intersection_of: towards GO:0097575 ! lateral cell cortex relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CHEBI:36080 ! protein relationship: towards GO:0097575 ! lateral cell cortex created_by: midori creation_date: 2015-07-27T13:55:26Z [Term] id: FYPO:0004731 name: normal protein localization to cytoplasmic microtubule plus-end def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the plus-end of a cytoplasmic microtubule is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to cytoplasmic microtubule plus-end" EXACT [PomBase:mah] synonym: "normal protein localization to cytoplasmic microtubule plus end" EXACT [PomBase:mah] synonym: "normal protein localization to cytoplasmic microtubule plus-end during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal protein localization to cytoplasmic microtubule plus-end during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001321 ! cellular physical quality phenotype during vegetative growth is_a: FYPO:0003184 ! normal protein localization to cytoskeleton during vegetative growth intersection_of: PATO:0001241 ! physical object quality intersection_of: happens__during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1904518 ! protein localization to cytoplasmic microtubule plus-end intersection_of: qualifier PATO:0000461 ! normal relationship: happens__during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1904518 ! protein localization to cytoplasmic microtubule plus-end relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-07-27T14:07:56Z [Term] id: FYPO:0004732 name: astral microtubules present in decreased numbers def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells contain fewer astral microtubules than normal." [PomBase:mah] synonym: "astral microtubules present in decreased numbers during mitotic cell cycle" RELATED [PomBase:mah] synonym: "astral microtubules present in decreased numbers during vegetative growth" EXACT [PomBase:mah] synonym: "astral microtubules present in reduced numbers" EXACT [PomBase:mah] synonym: "decreased level of astral microtubules" EXACT [PomBase:mah] synonym: "reduced number of astral microtubules" EXACT [PomBase:vw] is_a: FYPO:0003430 ! microtubules present in decreased numbers intersection_of: PATO:0002001 ! has fewer parts of type intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0000235 ! astral microtubule relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0000235 ! astral microtubule created_by: midori creation_date: 2015-07-27T14:26:14Z [Term] id: FYPO:0004733 name: cytoplasmic microtubules nucleated from equatorial microtubule organizing center present in decreased numbers def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the cell contains fewer cytoplasmic microtubules nucleated from the equatorial microtubule organizing center than normal." [PMID:15772152, PomBase:mah] synonym: "cytoplasmic microtubules nucleated from eMTOC present in decreased numbers" EXACT [PomBase:mah] synonym: "cytoplasmic microtubules nucleated from equatorial microtubule organizing center present in decreased numbers during mitotic cell cycle" RELATED [PomBase:mah] synonym: "cytoplasmic microtubules nucleated from equatorial microtubule organizing center present in decreased numbers during vegetative growth" EXACT [PomBase:mah] synonym: "cytoplasmic microtubules nucleated from equatorial microtubule organizing center present in reduced numbers" EXACT [PomBase:mah] synonym: "decreased number of cytoplasmic microtubules nucleated from equatorial microtubule organizing center" EXACT [PomBase:vw] synonym: "reduced number of cytoplasmic microtubules nucleated from equatorial microtubule organizing center" EXACT [PomBase:vw] is_a: FYPO:0003430 ! microtubules present in decreased numbers created_by: midori creation_date: 2015-07-27T14:39:08Z [Term] id: FYPO:0004734 name: decreased misfolded protein degradation def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the occurrence of degradation of misfolded or incompletely synthesized protein is decreased." [GO:0006515, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased misfolded or incompletely synthesized protein catabolic process" EXACT [GO:0006515, PomBase:mah] synonym: "decreased misfolded or incompletely synthesized protein degradation" EXACT [GO:0006515] synonym: "decreased misfolded protein degradation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased misfolded protein degradation during vegetative growth" EXACT [PomBase:mah] synonym: "misfolded or incompletely synthesized protein catabolism" EXACT [GO:0006515, PomBase:mah] synonym: "reduced misfolded protein degradation" EXACT [PomBase:mah] is_a: FYPO:0000845 ! abnormal protein degradation during vegetative growth is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0006515 ! misfolded or incompletely synthesized protein catabolic process relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0006515 ! misfolded or incompletely synthesized protein catabolic process created_by: midori creation_date: 2015-07-27T14:43:44Z [Term] id: FYPO:0004735 name: abolished protein localization to medial cortical node, with protein mislocalized to cytoplasm def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the medial cortical nodes is abolished, and the protein is present in the cytoplasm instead." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to medial cortical node, with protein mislocalised to cytoplasm" EXACT [PomBase:mah] synonym: "abolished protein localization to cortical medial dot, with protein mislocalized to cytoplasm" EXACT [PomBase:mah] synonym: "abolished protein localization to cytokinetic nodes, with protein mislocalized to cytoplasm" RELATED [PomBase:mah] synonym: "abolished protein localization to medial cortical node, with protein mislocalized to cytoplasm, during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to medial cortical node, with protein mislocalized to cytoplasm, during vegetative growth" EXACT [PomBase:mah] synonym: "abolished protein localization to medial cortical nodes, with protein mislocalized to cytoplasm" EXACT [PomBase:mah] synonym: "protein localization to medial cortical node abolished, with protein mislocalized to cytoplasm" EXACT [PomBase:mah] is_a: FYPO:0003919 ! abolished protein localization to medial cortical node intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000783 ! protein mislocalized to cytoplasm intersection_of: towards GO:1902577 ! protein localization to medial cortical node relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000783 ! protein mislocalized to cytoplasm relationship: towards GO:1902577 ! protein localization to medial cortical node created_by: midori creation_date: 2015-07-27T16:10:36Z [Term] id: FYPO:0004736 name: abnormal actomyosin contractile ring def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the position, composition or morphology of the actomyosin contractile ring is abnormal." [PomBase:mah] synonym: "abnormal actomyosin contractile ring during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal actomyosin contractile ring during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal contractile ring" EXACT [PomBase:mah] synonym: "abnormal cytokinetic contractile ring" EXACT [PomBase:vw] synonym: "abnormal mitotic contractile ring" EXACT [PomBase:vw] is_a: FYPO:0002398 ! abnormal actin cytoskeleton during vegetative growth intersection_of: PATO:0001241 ! physical object quality intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005826 ! actomyosin contractile ring intersection_of: qualifier PATO:0000460 ! abnormal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005826 ! actomyosin contractile ring relationship: output_of FYPO:0004738 ! abnormal actomyosin contractile ring organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-07-27T16:17:26Z [Term] id: FYPO:0004737 name: decreased F-actin level in actomyosin contractile ring during early mitosis def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the amount of filamentous actin (F-actin) in the actomyosin contractile ring is lower than normal during early mitosis (before anaphase)." [PMID:25688133, PomBase:mah] synonym: "decreased abundance of F-actin in the actomyosin contractile ring in early mitosis" EXACT [PomBase:vw] synonym: "decreased actomyosin contractile ring F-actin level during early mitosis" EXACT [PomBase:mah] synonym: "decreased F-actin level in mitotic contractile ring during early mitosis" EXACT [PomBase:vw] synonym: "decreased filamentous actin level in actomyosin contractile ring during early mitosis" EXACT [PomBase:mah] is_a: FYPO:0004736 ! abnormal actomyosin contractile ring created_by: midori creation_date: 2015-07-27T16:19:11Z [Term] id: FYPO:0004738 name: abnormal actomyosin contractile ring organization def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which actin cable organization is abnormal. The process normally results in the assembly, arrangement of constituent parts, or disassembly of the actomyosin contractile ring." [GO:0044837, PomBase:mah] synonym: "abnormal actomyosin contractile ring organisation" EXACT [PomBase:mah] synonym: "abnormal actomyosin contractile ring organization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal actomyosin contractile ring organization during vegetative growth" EXACT [PomBase:mah] synonym: "abnormal contractile ring organization" EXACT [PomBase:mah] synonym: "abnormal mitotic contractile ring organization" EXACT [PomBase:vw] is_a: FYPO:0000801 ! abnormal actin cytoskeleton organization during vegetative growth is_a: FYPO:0001354 ! abnormal cellular component assembly during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0044837 ! actomyosin contractile ring organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0044837 ! actomyosin contractile ring organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-07-27T16:38:21Z [Term] id: FYPO:0004739 name: normal actin cytoskeleton during vegetative growth def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the amount, distribution, or morphology of the actin cytoskeleton is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal actin cytoskeleton during mitotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0001313 ! normal subcellular component during vegetative growth intersection_of: PATO:0001241 ! physical object quality intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0015629 ! actin cytoskeleton intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0015629 ! actin cytoskeleton relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-07-27T16:44:24Z [Term] id: FYPO:0004740 name: normal actomyosin contractile ring def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the position, composition or morphology of the of the actomyosin contractile ring is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal actomyosin contractile ring during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal actomyosin contractile ring during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001313 ! normal subcellular component during vegetative growth intersection_of: PATO:0001241 ! physical object quality intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005826 ! actomyosin contractile ring intersection_of: qualifier PATO:0000461 ! normal relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005826 ! actomyosin contractile ring relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-07-27T16:46:48Z [Term] id: FYPO:0004741 name: normal F-actin level in actomyosin contractile ring during anaphase B def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the amount of filamentous actin (F-actin) in the actomyosin contractile ring is normal (i.e. indistinguishable from wild type) during mitotic anaphase B." [PMID:25688133, PomBase:mah] synonym: "normal abundance of actin in actomyosin contractile ring in anaphase B" EXACT [PomBase:vw] synonym: "normal actomyosin contractile ring F-actin level during anaphase B" EXACT [PomBase:mah] synonym: "normal F-actin level in contractile ring during anaphase B" EXACT [PomBase:al] synonym: "normal F-actin level in cytokinetic contractile ring during anaphase B" EXACT [PomBase:vw] synonym: "normal filamentous actin level in actomyosin contractile ring during anaphase B" EXACT [PomBase:mah] is_a: FYPO:0004740 ! normal actomyosin contractile ring is_a: PATO:0001159 ! concentrated intersection_of: PATO:0001159 ! concentrated intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0005826 ! actomyosin contractile ring intersection_of: qualifier PATO:0000461 ! normal intersection_of: towards GO:0031941 ! filamentous actin relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0005826 ! actomyosin contractile ring relationship: qualifier PATO:0000461 ! normal relationship: towards GO:0031941 ! filamentous actin created_by: midori creation_date: 2015-07-27T16:48:34Z [Term] id: FYPO:0004742 name: normal chromatin silencing at centromere outer repeat def: "A transcription regulation phenotype observed in the vegetative growth phase of the life cycle in which chromatin silencing at the outer repeat region of the centromere is normal (i.e. indistinguishable from wild type)." [PomBase:mah] comment: Note that the centromere outer repeat region corresponds to SO:0001799. synonym: "normal centromere outer repeat region chromatin silencing" EXACT [PomBase:mah] synonym: "normal chromatin silencing at centromere otr" EXACT [PomBase:mah] synonym: "normal chromatin silencing at centromere outer repeat region" EXACT [GO:1990141] synonym: "normal chromatin silencing at centromere outer repeat region during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal chromatin silencing at centromere outer repeat region during vegetative growth" EXACT [PomBase:mah] synonym: "normal chromatin silencing at centromeric outer repeat region" EXACT [PomBase:mah] synonym: "normal chromatin silencing at pericentric region" RELATED [PomBase:mah] synonym: "normal chromatin silencing at pericentromeric region" RELATED [PomBase:mah] synonym: "normal heterochromatic silencing at centromere outer repeat region" EXACT [PomBase:mah] synonym: "normal heterochromatin silencing at centromere outer repeat region" EXACT [PomBase:mah] is_a: FYPO:0001319 ! normal cellular process during vegetative growth is_a: FYPO:0001335 ! transcription regulation phenotype during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in_part_of GO:1990141 ! chromatin silencing at centromere outer repeat region intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in_part_of GO:1990141 ! chromatin silencing at centromere outer repeat region relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-07-28T11:03:58Z [Term] id: FYPO:0004743 name: normal histone H3-K9 dimethylation at centromere outer repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the dimethylation of lysine at position 9 of histone H3 in centromere outer repeat regions is normal (i.e. indistinguishable from wild type)." [PomBase:mah] synonym: "normal histone H3-K9 dimethylation at centromere otr" EXACT [PomBase:mah] synonym: "normal histone H3-K9 dimethylation at centromere outer repeat region" EXACT [PomBase:mah] synonym: "normal histone H3-K9 dimethylation at centromere outer repeat region during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal histone H3-K9 dimethylation at centromere outer repeat region during vegetative growth" EXACT [PomBase:mah] synonym: "normal histone H3-K9 dimethylation at pericentric region" RELATED [PomBase:mah] synonym: "normal histone H3-K9 dimethylation at pericentromeric region" RELATED [PomBase:mah] synonym: "normal histone H3K9me2 at centromere outer repeat" EXACT [PomBase:mah] is_a: FYPO:0000862 ! normal histone H3-K9 dimethylation at centromere is_a: FYPO:0003235 ! normal histone H3-K9 methylation at centromere outer repeat intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0036123 ! histone H3-K9 dimethylation intersection_of: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0036123 ! histone H3-K9 dimethylation relationship: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-07-28T11:13:39Z [Term] id: FYPO:0004744 name: normal heterochromatin maintenance involved in chromatin silencing at centromere outer repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which heterochromatin maintenance is normal (i.e. indistinguishable from wild type) in the context of chromatin silencing at centromere outer repeat regions." [GO:1902368, PMID:24240238, PomBase:mah] synonym: "normal heterochromatin maintenance involved in chromatin silencing at centromere otr" EXACT [PomBase:mah] synonym: "normal heterochromatin maintenance involved in chromatin silencing at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "normal heterochromatin maintenance involved in chromatin silencing at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] synonym: "normal heterochromatin maintenance involved in chromatin silencing at centromere outer repeat region" EXACT [GO:1902368, PomBase:mah] synonym: "normal heterochromatin maintenance involved in chromatin silencing at pericentric region" RELATED [PomBase:mah] synonym: "normal heterochromatin maintenance involved in chromatin silencing at pericentromeric region" RELATED [PomBase:mah] is_a: FYPO:0002892 ! normal heterochromatin organization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902368 ! heterochromatin maintenance involved in chromatin silencing at centromere outer repeat region intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902368 ! heterochromatin maintenance involved in chromatin silencing at centromere outer repeat region relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-07-28T11:25:15Z [Term] id: FYPO:0004745 name: abolished histone H3-K9 dimethylation at centromere outer repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which dimethylation of lysine at position 9 of histone H3 in centromere outer repeat regions does not occur." [PomBase:mah] synonym: "abolished histone H3 K9 dimethylation at centromere outer repeat" EXACT [GO:0036123, PomBase:mah] synonym: "abolished histone H3-K9 dimethylation at centromere otr" EXACT [PomBase:mah] synonym: "abolished histone H3-K9 dimethylation at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished histone H3-K9 dimethylation at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] synonym: "abolished histone H3-K9 dimethylation at centromere outer repeat region" EXACT [PomBase:vw] synonym: "abolished histone H3-K9 dimethylation at pericentric region" RELATED [PomBase:mah] synonym: "abolished histone H3-K9 dimethylation at pericentromeric region" RELATED [PomBase:mah] synonym: "abolished histone H3K9me2 at centromere outer repeat" EXACT [PomBase:mah] synonym: "abolished histone lysine H3 K9 dimethylation at centromere outer repeat" EXACT [GO:0036123, PomBase:mah] synonym: "histone H3-K9 dimethylation abolished at centromere outer repeat" EXACT [PomBase:mah] synonym: "histone H3-K9 dimethylation absent at centromere outer repeat" EXACT [PomBase:al] is_a: FYPO:0003097 ! abolished histone H3-K9 methylation at centromere outer repeat is_a: FYPO:0004170 ! abolished histone H3-K9 dimethylation at centromere intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region intersection_of: towards GO:0036123 ! histone H3-K9 dimethylation relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: occurs_at SO:0001799 ! regional_centromere_outer_repeat_region relationship: towards GO:0036123 ! histone H3-K9 dimethylation created_by: midori creation_date: 2015-07-28T11:28:54Z [Term] id: FYPO:0004746 name: abolished heterochromatin assembly involved in chromatin silencing at centromere outer repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which heterochromatin assembly involved in chromatin silencing at the centromere outer repeat region does not occur." [GO:1904497, PMID:24240238, PomBase:mah] synonym: "abolished heterochromatin assembly involved in chromatin silencing at centromere otr" EXACT [PomBase:mah] synonym: "abolished heterochromatin assembly involved in chromatin silencing at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished heterochromatin assembly involved in chromatin silencing at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] synonym: "abolished heterochromatin assembly involved in chromatin silencing at centromere outer repeat region" EXACT [GO:1904497] synonym: "abolished heterochromatin assembly involved in chromatin silencing at pericentric region" RELATED [PomBase:mah] synonym: "abolished heterochromatin assembly involved in chromatin silencing at pericentromeric region" RELATED [PomBase:mah] synonym: "heterochromatin assembly involved in chromatin silencing at centromere outer repeat abolished" EXACT [PomBase:mah] is_a: FYPO:0003098 ! abnormal heterochromatin assembly at centromere outer repeat is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1904497 ! heterochromatin assembly involved in chromatin silencing at centromere outer repeat region relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1904497 ! heterochromatin assembly involved in chromatin silencing at centromere outer repeat region created_by: midori creation_date: 2015-07-28T11:34:43Z [Term] id: FYPO:0004747 name: actin cortical patches present in greater numbers at cell tip during early mitosis def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which cells contain more actin cortical patches at one or both cell tips than normal during early mitosis (before anaphase)." [PMID:25688133, PomBase:mah] synonym: "accumulation of actin cortical patches at cell tip during early mitosis" RELATED [PomBase:vw] synonym: "actin cortical patches in greater numbers at cell tip during early mitosis during vegetative growth" EXACT [PomBase:mah] synonym: "actin cortical patches present in greater numbers at cell tip during cell growth during early mitotic nuclear division" EXACT [GO:0007067] synonym: "actin patches present in greater numbers at cell tip during early mitosis" EXACT [PomBase:vw] synonym: "additional actin cortical patches present at cell tip during early mitosis" EXACT [PomBase:mah] synonym: "extra actin cortical patches at cell tip during early mitosis" EXACT [PomBase:mah] synonym: "increased number of actin patches at cell tip in early mitosis" EXACT [PomBase:vw] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth created_by: midori creation_date: 2015-07-28T11:49:16Z [Term] id: FYPO:0004748 name: decreased histone exchange at pericentric heterochromatin def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone exchange occurs to a lower extent than normal in regions of pericentric heterochromatin. Histone exchange is replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits." [GO:0005721, GO:0043486, PMID:24095277, PomBase:mah] synonym: "decreased histone exchange at dh repeat" NARROW [PomBase:al] synonym: "decreased histone exchange at pericentric heterochromatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased histone exchange at pericentric heterochromatin during vegetative growth" EXACT [PomBase:mah] synonym: "reduced histone exchange at pericentric heterochromatin" EXACT [PomBase:mah] is_a: FYPO:0001352 ! abnormal chromatin organization during vegetative growth is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0043486 ! histone exchange intersection_of: occurs_at GO:0005721 ! pericentric heterochromatin relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0043486 ! histone exchange relationship: occurs_at GO:0005721 ! pericentric heterochromatin created_by: midori creation_date: 2015-07-28T12:20:18Z [Term] id: FYPO:0004749 name: increased spatial extent of telomeric heterochromatin assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which heterochromatin is assembled over a larger portion of the telomeric region of the chromosome than normal." [GO:0031509, PMID:25774602, PomBase:mah] synonym: "increased spatial extent of heterochromatin assembly at telomere" EXACT [PomBase:mah] synonym: "increased spatial extent of telomeric heterochromatin assembly during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased spatial extent of telomeric heterochromatin assembly during vegetative growth" EXACT [PomBase:mah] synonym: "increased spatial extent of telomeric heterochromatin formation" EXACT [GO:0031509] synonym: "telomeric heterochromatin spreading" RELATED [PMID:25774602] is_a: FYPO:0003044 ! abnormal heterochromatin assembly created_by: midori creation_date: 2015-07-28T12:26:06Z [Term] id: FYPO:0004750 name: elongated septated vegetative cell def: "A cell morphology phenotype observed in the vegetative growth phase of the life cycle in which cells are elongated and have one or more septa per cell." [PomBase:mah] synonym: "elongated septated cell during mitotic cell cycle" RELATED [PomBase:mah] synonym: "elongated septated cells during vegetative growth" EXACT [PomBase:mah] synonym: "long septated cells" EXACT [PomBase:vw] is_a: FYPO:0000002 ! cell phenotype intersection_of: FYPO:0000002 ! cell phenotype intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000017 ! elongated cell intersection_of: has_part FYPO:0002342 ! septated vegetative cell relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000017 ! elongated cell relationship: has_part FYPO:0002342 ! septated vegetative cell created_by: midori creation_date: 2015-07-28T12:45:02Z [Term] id: FYPO:0004751 name: resistance to G418 def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of G418 than normal." [PomBase:mah] synonym: "resistance to G418 during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to G418 during vegetative growth" EXACT [PomBase:mah] synonym: "resistance to Geneticin" EXACT [CHEBI:42768, PomBase:mah] synonym: "resistant to G418" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:42768 ! geneticin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:42768 ! geneticin created_by: midori creation_date: 2015-07-28T13:01:45Z [Term] id: FYPO:0004752 name: resistance to phleomycin def: "An increased chemical resistance phenotype observed in the vegetative growth phase of the life cycle in which cells grow in the presence of a higher concentration of phleomycin than normal." [PomBase:mah] synonym: "resistance to phleomycin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "resistance to phleomycin during vegetative growth" EXACT [PomBase:mah] synonym: "resistant to phleomycin" EXACT [PomBase:mah] is_a: FYPO:0000126 ! increased resistance to chemical during vegetative growth intersection_of: PATO:0001552 ! decreased sensitivity of a process intersection_of: inheres_in GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards CHEBI:75044 ! phleomycin relationship: inheres_in GO:0072690 ! single-celled organism vegetative growth phase relationship: towards CHEBI:75044 ! phleomycin created_by: midori creation_date: 2015-07-28T13:02:43Z [Term] id: FYPO:0004753 name: abolished protein localization to nucleus during mitotic interphase def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleus is abolished during interphase of the mitotic cell cycle." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to nucleus during mitotic interphase" EXACT [PomBase:mah] synonym: "abolished protein localization to nucleus during interphase during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished protein localization to nucleus during mitotic interphase during vegetative growth" EXACT [PomBase:mah] synonym: "protein localization to nucleus abolished during mitotic interphase" EXACT [PomBase:mah] is_a: FYPO:0001424 ! abolished protein localization to nucleus during vegetative growth intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0051329 ! mitotic interphase intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0034504 ! protein localization to nucleus relationship: during GO:0051329 ! mitotic interphase relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0034504 ! protein localization to nucleus created_by: midori creation_date: 2015-07-28T13:33:52Z [Term] id: FYPO:0004754 name: abolished protein localization to mitotic spindle during mitosis def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the mitotic spindle does not occur during mitosis." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localization to mitotic spindle during mitotic M phase" RELATED [PomBase:mah] synonym: "abolished protein localization to mitotic spindle during mitotic M-phase" RELATED [PomBase:vw] synonym: "abolished protein localization to mitotic spindle during mitotic nuclear division" EXACT [GO:0007067] synonym: "abolished protein localization to mitotic spindle pole body during mitotic M phase" EXACT [PomBase:mah] synonym: "protein absent from mitotic spindle during mitosis" RELATED [PomBase:mah] synonym: "protein localisation to mitotic spindle abolished during mitosis" EXACT [PomBase:mah] synonym: "protein localization to mitotic spindle abolished during mitosis" EXACT [PomBase:mah] synonym: "protein localization to spindle abolished during mitosis during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0003186 ! abolished protein localization to mitotic spindle intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0007067 ! mitotic nuclear division intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:1902480 ! protein localization to mitotic spindle relationship: during GO:0007067 ! mitotic nuclear division relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:1902480 ! protein localization to mitotic spindle created_by: midori creation_date: 2015-07-28T13:43:04Z [Term] id: FYPO:0004755 name: abnormal protein localization to microtubule minus-end def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the minus ends of microtubules is abnormal." [PMID:25987607, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localization to microtubule minus end" EXACT [PomBase:mah] synonym: "abnormal protein localization to microtubule minus-end during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal protein localization to microtubule minus-end during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000931 ! abnormal protein localization to microtubule cytoskeleton during vegetative growth is_a: FYPO:0004639 ! abnormal cellular physical quality phenotype during vegetative growth intersection_of: PATO:0001241 ! physical object quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1904519 ! protein localization to microtubule minus-end intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1904519 ! protein localization to microtubule minus-end relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-07-28T13:54:16Z [Term] id: FYPO:0004756 name: abnormal regulation of DNA replication initiation def: "A regulation phenotype in which regulation of the initiation of DNA-dependent DNA replication is abnormal." [PomBase:mah] synonym: "abnormal regulation of DNA replication initiation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal regulation of DNA-dependent DNA replication initiation" EXACT [GO:0006270, PomBase:mah] is_a: FYPO:0000145 ! regulation phenotype is_a: FYPO:0000628 ! abnormal cellular process intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0030174 ! regulation of DNA-dependent DNA replication initiation intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0030174 ! regulation of DNA-dependent DNA replication initiation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-07-28T14:00:03Z [Term] id: FYPO:0004757 name: abnormal negative regulation of DNA replication initiation def: "A regulation phenotype in which negative regulation of the initiation of DNA-dependent DNA replication is abnormal. May result in re-replication of all or part of the genome." [PomBase:mah] synonym: "abnormal negative regulation of DNA-dependent DNA replication initiation" EXACT [PomBase:mah] synonym: "DNA re-replication" RELATED [PomBase:mah] synonym: "DNA replication defects, endoreduplication" RELATED [PomBase:mah] synonym: "DNA rereplication" RELATED [PomBase:mah] is_a: FYPO:0004756 ! abnormal regulation of DNA replication initiation intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0032297 ! negative regulation of DNA-dependent DNA replication initiation intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0032297 ! negative regulation of DNA-dependent DNA replication initiation relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-07-28T14:00:54Z [Term] id: FYPO:0004758 name: abnormal negative regulation of premeiotic DNA replication initiation def: "A regulation phenotype in which negative regulation of the initiation of premeiotic DNA replication is abnormal. May result in re-replication of all or part of the genome." [PomBase:mah] synonym: "abnormal negative regulation of initiation of premeiotic DNA replication" EXACT [GO:1904513] synonym: "premeiotic DNA re-replication" RELATED [PomBase:mah] synonym: "premeiotic DNA rereplication" RELATED [PomBase:mah] is_a: FYPO:0004757 ! abnormal negative regulation of DNA replication initiation intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:1904513 ! negative regulation of initiation of premeiotic DNA replication intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:1904513 ! negative regulation of initiation of premeiotic DNA replication relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-07-28T14:15:28Z [Term] id: FYPO:0004759 name: abnormal negative regulation of premeiotic DNA replication initiation resulting in complete rereplication def: "A regulation phenotype observed in the vegetative growth phase of the life cycle in which negative regulation of the initiation of premeiotic DNA replication is abnormal, resulting in one or more rounds of rereplication of the entire genome." [PMID:10388806, PomBase:mah] synonym: "abnormal negative regulation of DNA replication initiation resulting in complete rereplication during meiotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal negative regulation of initiation of premeiotic DNA replication, resulting in complete rereplication" EXACT [GO:1904513] synonym: "abnormal negative regulation of premeiotic DNA replication initiation resulting in complete re-replication" EXACT [PomBase:mah] synonym: "complete premeiotic DNA re-replication" RELATED [PomBase:mah] synonym: "complete premeiotic DNA rereplication" RELATED [PomBase:mah] is_a: FYPO:0004758 ! abnormal negative regulation of premeiotic DNA replication initiation created_by: midori creation_date: 2015-07-28T14:16:58Z [Term] id: FYPO:0004760 name: abnormal sporulation resulting in formation of azygotic ascus with more than four spores def: "A sporulation phenotype in which azygotic asci that contain more than four, and up to eight, spores form following conjugation, diploid growth, and subsequent azygotic sporulation. Azygotic ascus formation occurs when meiosis takes place within a diploid cell rather than in a zygote produced by sporulation. Zygotes can resume vegetative growth and form colonies of diploid cells if returned to rich media before commitment to meiosis; under nitrogen starvation, diploid cells heterozygous for mating type will undergo azygotic meiosis. Azygotic asci have a characteristic linear morphology resembling that of a single vegetatively growing cell." [PomBase:mah, PomBase:vw] synonym: "8-spored azygotic asci" RELATED [PomBase:vw] synonym: "abnormal azygotic ascospore formation resulting in formation of asci with more than four spores" EXACT [GO:0030437, PomBase:mah] synonym: "abnormal sporulation resulting in formation of azygotic asci with more than four spores" EXACT [PomBase:mah] synonym: "azygotic asci with increased number of spores" EXACT [PomBase:vw] synonym: "eight-spored azygotic asci" RELATED [PomBase:vw] is_a: FYPO:0001893 ! abnormal sporulation resulting in formation of azygotic ascus with more or fewer than four spores is_a: FYPO:0003263 ! abnormal sporulation resulting in formation of ascus with more than four spores created_by: midori creation_date: 2015-07-28T14:26:07Z [Term] id: FYPO:0004761 name: increased histone exchange at pericentric heterochromatin def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which histone exchange occurs to a greater extent than normal in regions of pericentric heterochromatin. Histone exchange is replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits." [GO:0005721, GO:0043486, PMID:24095277, PomBase:mah] synonym: "increased histone exchange at dh repeat" NARROW [PomBase:al] synonym: "increased histone exchange at pericentric heterochromatin during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased histone exchange at pericentric heterochromatin during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001352 ! abnormal chromatin organization during vegetative growth is_a: PATO:0002051 ! increased occurrence intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0043486 ! histone exchange intersection_of: occurs_at GO:0005721 ! pericentric heterochromatin relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0043486 ! histone exchange relationship: occurs_at GO:0005721 ! pericentric heterochromatin created_by: midori creation_date: 2015-07-29T15:54:04Z [Term] id: FYPO:0004762 name: abnormal protein localization to kinetochore during meiosis def: "A cell phenotype in which the localization of a protein to the kinetochore is abnormal during one or both meiotic nuclear divisions." [PomBase:mah] comment: Encompasses both presence of proteins not normally found associated with the kinetochore and decreased levels or absence of proteins normally found there, and describes defects in a localization process. We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to kinetochore during meiosis" EXACT [PomBase:mah] synonym: "abnormal protein localization to kinetochore during meiotic nuclear division" EXACT [GO:0007126] synonym: "abnormal protein localization to meiotic kinetochore" EXACT [PomBase:vw] is_a: FYPO:0003549 ! abnormal protein localization during meiosis intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0007126 ! meiotic nuclear division intersection_of: inheres_in_part_of GO:0034501 ! protein localization to kinetochore intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0007126 ! meiotic nuclear division relationship: inheres_in_part_of GO:0034501 ! protein localization to kinetochore relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-07-29T16:05:37Z [Term] id: FYPO:0004763 name: abolished protein localization to kinetochore during meiosis I def: "A cell phenotype in which the localization of a protein to the kinetochore of a chromosome does not occur during the first meiotic nuclear division." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abolished protein localisation to kinetochore during meiosis I" EXACT [PomBase:mah] synonym: "abolished protein localization to kinetochore during first meiotic nuclear division" EXACT [PomBase:mah] synonym: "abolished protein localization to meiotic kinetochore during meiosis I" EXACT [PomBase:vw] synonym: "protein localization to kinetochore during meiosis I abolished" EXACT [PomBase:mah] is_a: FYPO:0001375 ! protein localization abolished is_a: FYPO:0004762 ! abnormal protein localization to kinetochore during meiosis intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0007127 ! meiosis I intersection_of: towards GO:0034501 ! protein localization to kinetochore relationship: during GO:0007127 ! meiosis I relationship: towards GO:0034501 ! protein localization to kinetochore created_by: midori creation_date: 2015-07-29T16:07:30Z [Term] id: FYPO:0004764 name: normal protein localization to meiotic spindle pole body during meiosis I def: "A cell phenotype in which the localization of a protein to the meiotic spindle pole body is normal (i.e. indistinguishable from wild type) during the first meiotic nuclear division." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "normal protein localisation to meiotic spindle pole body during meiosis I" EXACT [PomBase:mah] synonym: "normal protein localization to meiotic SPB during meiosis I" EXACT [PomBase:mah] synonym: "normal protein localization to meiotic spindle pole body during first meiotic nuclear division" EXACT [PomBase:mah] is_a: FYPO:0003541 ! normal protein localization to meiotic spindle pole body intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0007127 ! meiosis I intersection_of: inheres_in GO:1902441 ! protein localization to meiotic spindle pole body intersection_of: qualifier PATO:0000461 ! normal relationship: happens_during GO:0007127 ! meiosis I relationship: inheres_in GO:1902441 ! protein localization to meiotic spindle pole body relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-07-29T16:10:12Z [Term] id: FYPO:0004765 name: normal cell population growth during glucose limitation def: "A cell growth phenotype in which cell population growth is normal (i.e. indistinguishable from wild type) under conditions of glucose limitation, such as in a medium that contains a low level of glucose and no other carbon source." [PomBase:mah] comment: Use this term if you have assayed growth of cells exposed to glucose limitation in culture. Note that glucose limitation differs from glucose starvation in that starvation results from complete absence of glucose, whereas limitation results from a shift from high to low glucose levels. Glucose concentrations below about 4.4 mM (0.08%) are typically regarded as limiting. synonym: "normal growth during glucose limitation" BROAD [PomBase:mah] is_a: FYPO:0000047 ! normal cell population growth created_by: midori creation_date: 2015-07-29T16:20:55Z [Term] id: FYPO:0004766 name: abolished interphase microtubule nucleation def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which microtubule nucleation by the interphase microtubule organizing center during interphase does not occur." [GO:0051415, PMID:15772152, PomBase:mah] synonym: "abolished interphase microtubule nucleation by iMTOC" EXACT [PomBase:mah] synonym: "abolished interphase microtubule nucleation by interphase microtubule organizing center" EXACT [GO:0051415] synonym: "abolished interphase microtubule nucleation during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abolished interphase microtubule nucleation during vegetative growth" EXACT [PomBase:mah] synonym: "abolished microtubule nucleation during mitotic interphase" EXACT [PomBase:mah] synonym: "interphase microtubule nucleation abolished" EXACT [PomBase:mah] is_a: FYPO:0001350 ! abnormal microtubule cytoskeleton organization during vegetative growth is_a: PATO:0001558 ! lacking processual parts intersection_of: PATO:0001558 ! lacking processual parts intersection_of: during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: towards GO:0051415 ! interphase microtubule nucleation by interphase microtubule organizing center relationship: during GO:0072690 ! single-celled organism vegetative growth phase relationship: towards GO:0051415 ! interphase microtubule nucleation by interphase microtubule organizing center created_by: midori creation_date: 2015-08-03T13:36:32Z [Term] id: FYPO:0004767 name: increased vacuolar alanine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-alanine measured in the vacuole is higher than normal." [PomBase:mah] synonym: "increased level of alanine in vacuole" EXACT [PomBase:mah] synonym: "increased vacuolar alanine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased vacuolar alanine level during vegetative growth" EXACT [PomBase:mah] synonym: "increased vacuolar L-alanine level" EXACT [PomBase:mah] is_a: FYPO:0001730 ! increased level of substance in vacuole is_a: FYPO:0003986 ! increased cellular amino acid level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: towards CHEBI:16977 ! L-alanine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: towards CHEBI:16977 ! L-alanine created_by: midori creation_date: 2015-08-03T14:03:37Z [Term] id: FYPO:0004768 name: increased vacuolar arginine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-arginine measured in the vacuole is higher than normal." [PomBase:mah] synonym: "increased level of arginine in vacuole" EXACT [PomBase:mah] synonym: "increased vacuolar arginine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased vacuolar arginine level during vegetative growth" EXACT [PomBase:mah] synonym: "increased vacuolar L-arginine level" EXACT [PomBase:mah] is_a: FYPO:0001730 ! increased level of substance in vacuole is_a: FYPO:0003986 ! increased cellular amino acid level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: towards CHEBI:16467 ! L-arginine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: towards CHEBI:16467 ! L-arginine created_by: midori creation_date: 2015-08-03T14:03:43Z [Term] id: FYPO:0004769 name: increased vacuolar asparagine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-asparagine measured in the vacuole is higher than normal." [PomBase:mah] synonym: "increased level of asparagine in vacuole" EXACT [PomBase:mah] synonym: "increased vacuolar asparagine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased vacuolar asparagine level during vegetative growth" EXACT [PomBase:mah] synonym: "increased vacuolar L-asparagine level" EXACT [PomBase:mah] is_a: FYPO:0001730 ! increased level of substance in vacuole is_a: FYPO:0003986 ! increased cellular amino acid level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: towards CHEBI:17196 ! L-asparagine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: towards CHEBI:17196 ! L-asparagine created_by: midori creation_date: 2015-08-03T14:03:46Z [Term] id: FYPO:0004770 name: increased vacuolar glutamine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-glutamine measured in the vacuole is higher than normal." [PomBase:mah] synonym: "increased level of glutamine in vacuole" EXACT [PomBase:mah] synonym: "increased vacuolar glutamine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased vacuolar glutamine level during vegetative growth" EXACT [PomBase:mah] synonym: "increased vacuolar L-glutamine level" EXACT [PomBase:mah] is_a: FYPO:0001730 ! increased level of substance in vacuole is_a: FYPO:0003986 ! increased cellular amino acid level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: towards CHEBI:18050 ! L-glutamine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: towards CHEBI:18050 ! L-glutamine created_by: midori creation_date: 2015-08-03T14:03:50Z [Term] id: FYPO:0004771 name: increased vacuolar glycine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of glycine measured in the vacuole is higher than normal." [PomBase:mah] synonym: "increased level of glycine in vacuole" EXACT [PomBase:mah] synonym: "increased vacuolar glycine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased vacuolar glycine level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001730 ! increased level of substance in vacuole is_a: FYPO:0003986 ! increased cellular amino acid level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: towards CHEBI:15428 ! glycine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: towards CHEBI:15428 ! glycine created_by: midori creation_date: 2015-08-03T14:04:01Z [Term] id: FYPO:0004772 name: increased vacuolar histidine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-histidine measured in the vacuole is higher than normal." [PomBase:mah] synonym: "increased level of histidine in vacuole" EXACT [PomBase:mah] synonym: "increased vacuolar histidine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased vacuolar histidine level during vegetative growth" EXACT [PomBase:mah] synonym: "increased vacuolar L-histidine level" EXACT [PomBase:mah] is_a: FYPO:0001567 ! increased cellular histidine level is_a: FYPO:0001730 ! increased level of substance in vacuole intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: towards CHEBI:15971 ! L-histidine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: towards CHEBI:15971 ! L-histidine created_by: midori creation_date: 2015-08-03T14:04:08Z [Term] id: FYPO:0004773 name: increased vacuolar lysine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-lysine measured in the vacuole is higher than normal." [PomBase:mah] synonym: "increased level of lysine in vacuole" EXACT [PomBase:mah] synonym: "increased vacuolar L-lysine level" EXACT [PomBase:mah] synonym: "increased vacuolar lysine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased vacuolar lysine level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001730 ! increased level of substance in vacuole is_a: FYPO:0003986 ! increased cellular amino acid level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: towards CHEBI:18019 ! L-lysine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: towards CHEBI:18019 ! L-lysine created_by: midori creation_date: 2015-08-03T14:04:12Z [Term] id: FYPO:0004774 name: increased vacuolar proline level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-proline measured in the vacuole is higher than normal." [PomBase:mah] synonym: "increased level of proline in vacuole" EXACT [PomBase:mah] synonym: "increased vacuolar L-proline level" EXACT [PomBase:mah] synonym: "increased vacuolar proline level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased vacuolar proline level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001730 ! increased level of substance in vacuole is_a: FYPO:0003986 ! increased cellular amino acid level intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: towards CHEBI:17203 ! L-proline relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: towards CHEBI:17203 ! L-proline created_by: midori creation_date: 2015-08-03T14:04:16Z [Term] id: FYPO:0004775 name: increased vacuolar serine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-serine measured in the vacuole is higher than normal." [PomBase:mah] synonym: "increased level of serine in vacuole" EXACT [PomBase:mah] synonym: "increased vacuolar L-serine level" EXACT [PomBase:mah] synonym: "increased vacuolar serine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased vacuolar serine level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001728 ! increased cellular serine level is_a: FYPO:0001730 ! increased level of substance in vacuole intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: towards CHEBI:17115 ! L-serine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: towards CHEBI:17115 ! L-serine created_by: midori creation_date: 2015-08-03T14:04:20Z [Term] id: FYPO:0004776 name: increased vacuolar threonine level def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of L-threonine measured in the vacuole is higher than normal." [PomBase:mah] synonym: "increased level of threonine in vacuole" EXACT [PomBase:mah] synonym: "increased vacuolar L-threonine level" EXACT [PomBase:mah] synonym: "increased vacuolar threonine level during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased vacuolar threonine level during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001565 ! increased cellular threonine level is_a: FYPO:0001730 ! increased level of substance in vacuole intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0000324 ! fungal-type vacuole intersection_of: towards CHEBI:16857 ! L-threonine relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0000324 ! fungal-type vacuole relationship: towards CHEBI:16857 ! L-threonine created_by: midori creation_date: 2015-08-03T14:04:23Z [Term] id: FYPO:0004777 name: abnormal farnesyltranstransferase activity def: "A molecular function phenotype in which the observed rate of farnesyltranstransferase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004311 ! farnesyltranstransferase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0004311 ! farnesyltranstransferase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-08-03T14:32:39Z [Term] id: FYPO:0004778 name: decreased farnesyltranstransferase activity def: "A molecular function phenotype in which the observed rate of farnesyltranstransferase activity is decreased." [PomBase:mah] synonym: "reduced farnesyltranstransferase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0004777 ! abnormal farnesyltranstransferase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0004311 ! farnesyltranstransferase activity relationship: inheres_in GO:0004311 ! farnesyltranstransferase activity created_by: midori creation_date: 2015-08-03T14:32:45Z [Term] id: FYPO:0004779 name: normal farnesyltranstransferase activity def: "A molecular function phenotype in which the observed rate of farnesyltranstransferase activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0004311 ! farnesyltranstransferase activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:0004311 ! farnesyltranstransferase activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-08-03T14:34:21Z [Term] id: FYPO:0004780 name: decreased protein localization to plasma membrane, with protein mislocalized to cytoplasm def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the plasma membrane is decreased, and some of the protein is present in the cytoplasm instead." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to plasma membrane, with protein mislocalised to cytoplasm" EXACT [PomBase:mah] synonym: "decreased protein localization in plasma membrane, with protein mislocalized to cytoplasm" EXACT [GO:0072659] synonym: "decreased protein localization to plasma membrane, with protein mislocalized to cytoplasm, during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to plasma membrane, with protein mislocalized to cytoplasm, during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to plasma membrane, with protein mislocalized to cytoplasm" EXACT [PomBase:mah] is_a: FYPO:0002125 ! abnormal protein localization to plasma membrane is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: has_part FYPO:0000783 ! protein mislocalized to cytoplasm intersection_of: inheres_in GO:0072659 ! protein localization to plasma membrane relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: has_part FYPO:0000783 ! protein mislocalized to cytoplasm relationship: inheres_in GO:0072659 ! protein localization to plasma membrane created_by: midori creation_date: 2015-08-03T14:35:38Z [Term] id: FYPO:0004781 name: delayed mitotic G2 DNA damage checkpoint def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the mitotic G2 DNA damage checkpoint begins later than normal under conditions that normally trigger the checkpoint signaling and response. Normally, the mitotic G2 DNA damage checkpoint negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [PomBase:mah] synonym: "delayed G2 DNA damage checkpoint during mitotic cell cycle" EXACT [PomBase:mah] synonym: "delayed mitotic G2 DNA damage checkpoint during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0004373 ! abnormal mitotic G2 DNA damage checkpoint is_a: PATO:0000502 ! delayed intersection_of: PATO:0000502 ! delayed intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0007095 ! mitotic G2 DNA damage checkpoint relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0007095 ! mitotic G2 DNA damage checkpoint created_by: midori creation_date: 2015-08-03T14:43:09Z [Term] id: FYPO:0004782 name: spores resistant to ionizing radiation def: "A cell phenotype in which spores germinate to a greater extent than wild type following exposure to ionizing radiation." [PMID:25533340, PomBase:mah] synonym: "resistant to ionizing radiation in spore phase" EXACT [PomBase:mah] synonym: "spores resistant to IR" EXACT [PomBase:mah] is_a: FYPO:0003037 ! abnormal cell phenotype created_by: midori creation_date: 2015-08-03T14:54:34Z [Term] id: FYPO:0004783 name: abnormal histone methyltransferase activity def: "A molecular function phenotype in which the observed rate of a histone methyltransferase activity is abnormal." [PomBase:mah] is_a: FYPO:0000661 ! abnormal catalytic activity intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:0042054 ! histone methyltransferase activity intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in GO:0042054 ! histone methyltransferase activity relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-08-03T15:05:05Z [Term] id: FYPO:0004784 name: decreased histone methyltransferase activity def: "A molecular function phenotype in which the observed rate of a histone methyltransferase activity is decreased." [PomBase:mah] synonym: "reduced histone methyltransferase activity" EXACT [PomBase:mah] is_a: FYPO:0000663 ! decreased catalytic activity is_a: FYPO:0004783 ! abnormal histone methyltransferase activity intersection_of: PATO:0002052 ! decreased occurrence intersection_of: inheres_in GO:0042054 ! histone methyltransferase activity relationship: inheres_in GO:0042054 ! histone methyltransferase activity created_by: midori creation_date: 2015-08-03T15:05:12Z [Term] id: FYPO:0004785 name: increased RNA level during cellular response to menadione def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of RNA measured in a cell during a cellular response to menadione is higher than normal. Total RNA or a specific RNA may be affected." [PomBase:mah] comment: Consider annotating to a term describing abnormal transcription or abnormal regulation of transcription, but note that changes in RNA levels may result from changes in RNA stability as well as changes in transcription. We recommend noting which RNA(s) were used in the assay when annotating to this term. synonym: "increased mRNA level during cellular response to menadione" NARROW [PomBase:mah] synonym: "increased RNA accumulation during cellular response to menadione" RELATED [PomBase:mah] synonym: "increased RNA level during cellular response to menadione during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased RNA level during cellular response to menadione during vegetative growth" EXACT [PomBase:mah] synonym: "increased transcript level during cellular response to menadione" EXACT [PomBase:vw] is_a: FYPO:0000825 ! increased RNA level during vegetative growth intersection_of: PATO:0001162 ! increased concentration intersection_of: exists_during GO:0036245 ! cellular response to menadione intersection_of: exists_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) intersection_of: towards CHEBI:33697 ! ribonucleic acid relationship: exists_during GO:0036245 ! cellular response to menadione relationship: exists_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in CL:0000334 ! vegetative cell (sensu Fungi) relationship: towards CHEBI:33697 ! ribonucleic acid created_by: midori creation_date: 2015-08-03T15:14:58Z [Term] id: FYPO:0004786 name: decreased protein localization to Golgi apparatus def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the Golgi apparatus is decreased." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to Golgi apparatus" EXACT [PomBase:mah] synonym: "decreased protein localization to Golgi apparatus during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased protein localization to Golgi apparatus during vegetative growth" EXACT [PomBase:mah] synonym: "reduced protein localization to Golgi apparatus" EXACT [PomBase:mah] is_a: FYPO:0003936 ! abnormal protein localization to Golgi apparatus is_a: PATO:0002052 ! decreased occurrence intersection_of: PATO:0002052 ! decreased occurrence intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:0034067 ! protein localization to Golgi apparatus relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:0034067 ! protein localization to Golgi apparatus created_by: midori creation_date: 2015-08-05T11:59:24Z [Term] id: FYPO:0004787 name: normal DNA/DNA annealing activity def: "A molecular function phenotype in which the observed rate of a DNA/DNA annealing activity is normal (i.e. indistinguishable from wild type)." [PomBase:mah] is_a: FYPO:0000660 ! normal catalytic activity is_a: FYPO:0001092 ! binding phenotype intersection_of: PATO:0000001 ! quality intersection_of: inheres_in GO:1990814 ! DNA/DNA annealing activity intersection_of: qualifier PATO:0000461 ! normal relationship: inheres_in GO:1990814 ! DNA/DNA annealing activity relationship: qualifier PATO:0000461 ! normal created_by: midori creation_date: 2015-08-05T12:12:51Z [Term] id: FYPO:0004788 name: increased protein serine phosphorylation during glucose starvation def: "A cellular process phenotype in which the phosphorylation of serine residues in one or more specific proteins, or of specific protein sites, occurs to a greater extent than normal when the cell is subject to glucose starvation." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "increased peptidyl-serine phosphorylation during glucose starvation" EXACT [GO:0018105, PomBase:mah] synonym: "increased protein serine phosphorylation during cellular response to glucose starvation" EXACT [PomBase:mah] synonym: "increased protein serine phosphorylation during glucose depletion" EXACT [PomBase:mah] synonym: "increased protein serine phosphorylation during glucose deprivation" EXACT [PomBase:mah] synonym: "increased serine phosphorylation during glucose starvation" EXACT [PomBase:al] is_a: FYPO:0004420 ! increased protein serine phosphorylation intersection_of: PATO:0002051 ! increased occurrence intersection_of: happens_during GO:0042149 ! cellular response to glucose starvation intersection_of: inheres_in GO:0018105 ! peptidyl-serine phosphorylation relationship: happens_during GO:0042149 ! cellular response to glucose starvation relationship: inheres_in GO:0018105 ! peptidyl-serine phosphorylation created_by: midori creation_date: 2015-08-05T12:13:36Z [Term] id: FYPO:0004789 name: circularized chromosome during mitotic G2 phase def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which telomeres have fused, forming circular chromosomes, during G2 phase of the mitotic cell cycle." [PMID:25533340, PomBase:mah] synonym: "circular chromosomes during mitotic G2 phase" EXACT [PomBase:mah] synonym: "circularised chromosome during mitotic G2 phase" EXACT [PomBase:mah] synonym: "circularized chromosome during G2 during vegetative growth" EXACT [PomBase:mah] synonym: "fused telomeres during mitotic G2 phase" RELATED [PomBase:mah] synonym: "telomere end fusion during mitotic G2 phase" RELATED [PomBase:mah] synonym: "telomere fusion during mitotic G2 phase" RELATED [PomBase:mah] synonym: "telomeres fused during mitotic G2 phase" RELATED [PomBase:mah] is_a: FYPO:0002702 ! circularized chromosome created_by: midori creation_date: 2015-08-05T12:16:51Z [Term] id: FYPO:0004790 name: abnormal telomere-nuclear envelope distance def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the distance between one or more telomeres and the nuclear envelope is abnormal (i.e. greater or less than the distance in wild type cells)." [PMID:22959349, PomBase:mah] synonym: "abnormal distance between telomeres and nuclear envelope" EXACT [PomBase:mah] synonym: "abnormal telomere-nuclear envelope distance during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal telomere-nuclear envelope distance during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0001322 ! abnormal subcellular component during vegetative growth relationship: output_of FYPO:0001515 ! abnormal telomere tethering at nuclear periphery created_by: midori creation_date: 2015-08-05T12:22:07Z [Term] id: FYPO:0004791 name: increased telomere-nuclear envelope distance during mitotic G2 phase def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the distance between one or more telomeres and the nuclear envelope is greater than normal during G2 phase of the mitotic cell cycle." [PMID:22959349, PomBase:mah] synonym: "increased distance between telomeres and nuclear envelope during mitotic G2 phase" EXACT [PomBase:mah] synonym: "increased telomere-nuclear envelope distance during G2 phase during mitotic cell cycle" RELATED [PomBase:mah] synonym: "increased telomere-nuclear envelope distance during mitotic G2 phase during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0004790 ! abnormal telomere-nuclear envelope distance created_by: midori creation_date: 2015-08-05T12:29:09Z [Term] id: FYPO:0004792 name: decreased telomere-nuclear envelope distance during mitotic G2 phase def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the distance between one or more telomeres and the nuclear envelope is smaller than normal during G2 phase of the mitotic cell cycle." [PMID:22959349, PomBase:mah] synonym: "decreased distance between telomeres and nuclear envelope during mitotic G2 phase" EXACT [PomBase:mah] synonym: "decreased telomere-nuclear envelope distance during G2 phase during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased telomere-nuclear envelope distance during mitotic G2 phase during vegetative growth" EXACT [PomBase:mah] synonym: "reduced telomere-nuclear envelope distance during mitotic G2 phase" EXACT [PomBase:mah] is_a: FYPO:0004790 ! abnormal telomere-nuclear envelope distance created_by: midori creation_date: 2015-08-05T12:31:42Z [Term] id: FYPO:0004793 name: decreased telomere-nuclear envelope distance during mitotic M phase def: "A physical cellular phenotype observed in the vegetative growth phase of the life cycle in which the distance between one or more telomeres and the nuclear envelope is smaller than normal during M phase of the mitotic cell cycle." [PMID:22959349, PomBase:mah] synonym: "decreased distance between telomeres and nuclear envelope during mitotic M phase" EXACT [PomBase:mah] synonym: "decreased telomere-nuclear envelope distance during M phase during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased telomere-nuclear envelope distance during mitotic M phase during vegetative growth" EXACT [PomBase:mah] synonym: "reduced telomere-nuclear envelope distance during mitotic M phase" EXACT [PomBase:mah] is_a: FYPO:0004790 ! abnormal telomere-nuclear envelope distance created_by: midori creation_date: 2015-08-05T12:32:21Z [Term] id: FYPO:0004794 name: decreased protein phosphorylation at Ser/Thr-Pro site def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which the phosphorylation of serine or threonine residues N-terminal to proline residues (i.e. in Ser/Thr-Pro sequences) occurs to a lower extent than normal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein phosphorylation at S/TP site" EXACT [PomBase:mah] synonym: "decreased protein phosphorylation at serine/threonine-proline site" EXACT [PomBase:mah] synonym: "decreased protein serine or threonine phosphorylation at Ser/Thr-Pro site" EXACT [PomBase:mah] synonym: "reduced protein phosphorylation at Ser/Thr-Pro site" EXACT [PomBase:mah] is_a: FYPO:0001838 ! decreased protein phosphorylation during vegetative growth created_by: midori creation_date: 2015-08-05T12:56:27Z [Term] id: FYPO:0004795 name: normal zygotic meiosis def: "A cellular process phenotype in which the meiotic nuclear divisions are normal (i.e. indistinguishable from wild type) during a cycle of zygotic meiosis and sporulation. Zygotic meiosis and sporulation take place under conditions of continuous nitrogen starvation, in which haploid cells of the opposite mating types conjugate to form diploid zygotes that proceed immediately to undergo meiosis and sporulation." [PMID:22558440, PMID:25891897, PomBase:mah] synonym: "normal meiosis during zygotic meiosis" EXACT [PomBase:vw] synonym: "normal zygotic meiotic nuclear division" EXACT [GO:0007126] is_a: FYPO:0000478 ! normal meiosis created_by: midori creation_date: 2015-08-07T11:44:07Z [Term] id: FYPO:0004796 name: normal azygotic meiosis def: "A cellular process phenotype in which the meiotic nuclear divisions are normal (i.e. indistinguishable from wild type) during a cycle of azygotic meiosis and sporulation. Azygotic meiosis and sporulation occur when meiosis takes place within a diploid cell rather than in a zygote produced by sporulation. Zygotes can resume vegetative growth and form colonies of diploid cells if returned to rich media before commitment to meiosis; under nitrogen starvation, diploid cells heterozygous for mating type will undergo azygotic meiosis. Azygotic asci have a characteristic linear morphology resembling that of a single vegetatively growing cell." [PMID:22558440, PMID:25891897, PomBase:mah] synonym: "normal azygotic meiotic nuclear division" EXACT [GO:0007126] synonym: "normal meiosis during azygotic meiosis" EXACT [PomBase:vw] is_a: FYPO:0000478 ! normal meiosis created_by: midori creation_date: 2015-08-07T11:55:56Z [Term] id: FYPO:0004797 name: normal azygotic meiosis I def: "A cellular process phenotype in which the first meiotic nuclear division is normal (i.e. indistinguishable from wild type) during a cycle of azygotic meiosis and sporulation. Azygotic meiosis and sporulation occur when meiosis takes place within a diploid cell rather than in a zygote produced by sporulation. Zygotes can resume vegetative growth and form colonies of diploid cells if returned to rich media before commitment to meiosis; under nitrogen starvation, diploid cells heterozygous for mating type will undergo azygotic meiosis. Azygotic asci have a characteristic linear morphology resembling that of a single vegetatively growing cell." [PMID:22558440, PMID:25891897, PomBase:mah] synonym: "normal azygotic first meiotic nuclear division" EXACT [GO:0007126] synonym: "normal meiosis I during azygotic meiosis" EXACT [PomBase:vw] is_a: FYPO:0003563 ! normal meiosis I created_by: midori creation_date: 2015-08-07T11:57:35Z [Term] id: FYPO:0004798 name: abolished azygotic meiosis II def: "A cellular process phenotype in which the second meiotic nuclear division does not occur during a cycle of azygotic meiosis and sporulation. Azygotic meiosis and sporulation occur when meiosis takes place within a diploid cell rather than in a zygote produced by sporulation. Zygotes can resume vegetative growth and form colonies of diploid cells if returned to rich media before commitment to meiosis; under nitrogen starvation, diploid cells heterozygous for mating type will undergo azygotic meiosis. Azygotic asci have a characteristic linear morphology resembling that of a single vegetatively growing cell." [PMID:22558440, PMID:25891897, PomBase:mah] synonym: "abolished azygotic second meiotic nuclear division" EXACT [GO:0007126] synonym: "abolished meiosis II during azygotic meiosis" EXACT [PomBase:vw] is_a: FYPO:0003379 ! abolished meiosis II created_by: midori creation_date: 2015-08-07T11:59:50Z [Term] id: FYPO:0004799 name: abolished zygotic meiosis II def: "A cellular process phenotype in which the second meiotic nuclear division does not occur during a cycle of zygotic meiosis and sporulation. Zygotic meiosis and sporulation take place under conditions of continuous nitrogen starvation, in which haploid cells of the opposite mating types conjugate to form diploid zygotes that proceed immediately to undergo meiosis and sporulation." [PMID:22558440, PMID:25891897, PomBase:mah] synonym: "abolished meiosis II during zygotic meiosis" EXACT [PomBase:vw] synonym: "abolished zygotic second meiotic nuclear division" EXACT [GO:0007126] is_a: FYPO:0003379 ! abolished meiosis II created_by: midori creation_date: 2015-08-07T12:01:35Z [Term] id: FYPO:0004800 name: abolished premeiotic DNA replication during azygotic meiosis def: "A cellular process phenotype in which premeiotic DNA replication does not occur during a cycle of azygotic meiosis and sporulation. Azygotic meiosis and sporulation occur when meiosis takes place within a diploid cell rather than in a zygote produced by sporulation. Zygotes can resume vegetative growth and form colonies of diploid cells if returned to rich media before commitment to meiosis; under nitrogen starvation, diploid cells heterozygous for mating type will undergo azygotic meiosis. Azygotic asci have a characteristic linear morphology resembling that of a single vegetatively growing cell." [PMID:22558440, PMID:25891897, PomBase:mah] synonym: "abolished DNA replication before azygotic meiosis" EXACT [PomBase:mah] synonym: "abolished premeiotic DNA replication during azygotic meiosis and sporulation" EXACT [PomBase:mah] synonym: "abolished premeiotic DNA replication during azygotic meiotic cell cycle" RELATED [PomBase:mah] synonym: "absent premeiotic DNA replication during azygotic meiosis" EXACT [PomBase:mah] synonym: "premeiotic DNA replication abolished during azygotic meiosis" EXACT [PomBase:mah] is_a: FYPO:0002044 ! abolished premeiotic DNA replication created_by: midori creation_date: 2015-08-07T12:03:30Z [Term] id: FYPO:0004801 name: delayed premeiotic DNA replication during azygotic meiosis def: "A cellular process phenotype in which premeiotic DNA replication begins later than normal during a cycle of azygotic meiosis and sporulation. Azygotic meiosis and sporulation occur when meiosis takes place within a diploid cell rather than in a zygote produced by sporulation. Zygotes can resume vegetative growth and form colonies of diploid cells if returned to rich media before commitment to meiosis; under nitrogen starvation, diploid cells heterozygous for mating type will undergo azygotic meiosis. Azygotic asci have a characteristic linear morphology resembling that of a single vegetatively growing cell." [PMID:22558440, PMID:25891897, PomBase:mah] synonym: "delayed DNA replication before azygotic meiosis" EXACT [PomBase:mah] synonym: "delayed premeiotic DNA replication during azygotic meiosis and sporulation" EXACT [PomBase:mah] synonym: "delayed premeiotic DNA replication during azygotic meiotic cell cycle" RELATED [PomBase:mah] is_a: FYPO:0004628 ! delayed premeiotic DNA replication created_by: midori creation_date: 2015-08-07T12:06:12Z [Term] id: FYPO:0004802 name: abnormal protein localization to shmoo tip def: "A cell phenotype in which the localization of a protein to the tip of a shmoo, or mating projection, is abnormal." [PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "abnormal protein localisation to shmoo tip" EXACT [PomBase:mah] synonym: "abnormal protein localization to mating projection tip" EXACT [PomBase:mah] synonym: "abnormal protein localization to shmoo projection" EXACT [PomBase:al] is_a: FYPO:0000443 ! abnormal protein localization during vegetative growth intersection_of: PATO:0000001 ! quality intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1903260 ! protein localization to mating projection tip intersection_of: qualifier PATO:0000460 ! abnormal relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1903260 ! protein localization to mating projection tip relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-08-11T14:49:17Z [Term] id: FYPO:0004803 name: abnormal actin cytoskeleton organization def: "A cellular process phenotype in which actin cytoskeleton organization is abnormal." [GO:0030036, PMID:19713940, PomBase:mah] comment: Consider annotating to 'abnormal actin cytoskeleton' (FYPO:0002398), but note that an abnormal actin cytoskeleton organization process may, but does not necessarily, result in a physically abnormal actin cytoskeleton. synonym: "abnormal actin cytoskeleton organisation" EXACT [PomBase:mah] synonym: "abnormal actin cytoskeleton organization during mitotic cell cycle" RELATED [PomBase:mah] synonym: "abnormal actin cytoskeleton organization during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0000296 ! actin cytoskeleton organization phenotype is_a: FYPO:0000802 ! abnormal cytoskeleton organization intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0030036 ! actin cytoskeleton organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0030036 ! actin cytoskeleton organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-08-11T14:55:28Z [Term] id: FYPO:0004804 name: abolished actin fusion focus assembly def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in which actin fusion focus assembly does not occur. An actin fusion focus normally forms during mating at the site where the two cells will fuse." [PMID:25825517, PomBase:mah] synonym: "abolished actin fusion focus formation" EXACT [PomBase:mah] synonym: "actin fusion focus assembly abolished" EXACT [PomBase:mah] is_a: FYPO:0004803 ! abnormal actin cytoskeleton organization created_by: midori creation_date: 2015-08-11T14:59:56Z [Term] id: FYPO:0004805 name: abnormal cell wall organization def: "A cellular process phenotype in which cell wall organization is abnormal. Cell wall organization results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall." [GO:0031505, PomBase:mah] synonym: "abnormal cell wall organisation" RELATED [PomBase:mah] synonym: "abnormal fungal-type cell wall organization" EXACT [PomBase:mah] is_a: FYPO:0000335 ! abnormal cellular component organization intersection_of: PATO:0000001 ! quality intersection_of: inheres_in_part_of GO:0031505 ! fungal-type cell wall organization intersection_of: qualifier PATO:0000460 ! abnormal relationship: inheres_in_part_of GO:0031505 ! fungal-type cell wall organization relationship: qualifier PATO:0000460 ! abnormal created_by: midori creation_date: 2015-08-11T15:06:43Z [Term] id: FYPO:0004806 name: incomplete cell wall disassembly at cell fusion site def: "A cellular process phenotype in which the cell wall is broken down to a lesser extent than in wild type at the site of cell-cell fusion during mating." [PMID:25825517, PomBase:mah] synonym: "incomplete cell wall disassembly at cell fusion site during conjugation with cellular fusion" EXACT [PomBase:mah] synonym: "incomplete cell wall disassembly at cell fusion site during mating" EXACT [PomBase:mah] synonym: "incomplete cell wall disassembly at cell-cell fusion focus" EXACT [PomBase:al] synonym: "incomplete cell wall disassembly at cell-cell fusion site" EXACT [PomBase:mah] synonym: "incomplete fungal-type cell wall disassembly at cell fusion site" EXACT [GO:0071853] is_a: FYPO:0004805 ! abnormal cell wall organization created_by: midori creation_date: 2015-08-11T15:08:11Z [Term] id: FYPO:0004807 name: narrow cell fusion site following conjugation with cellular fusion def: "A cell morphology phenotype in which the cell is narrower than normal at the point where cell fusion occurred during mating. Normlly, the cell expands at the fusion site after fusion takes place." [PMID:25825517, PomBase:mah] synonym: "narrow cell fusion site following mating" EXACT [PomBase:mah] synonym: "narrow cell-cell fusion site following conjugation with cellular fusion" EXACT [PomBase:mah] is_a: FYPO:0001126 ! abnormal cell shape created_by: midori creation_date: 2015-08-11T15:13:53Z [Term] id: FYPO:0004808 name: increased cellular protein aggregate level during cellular response to heat def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the amount of protein present as aggregates of misfolded protein is greater than normal during a cellular response to heat." [PMID:25543137, PomBase:mah] is_a: FYPO:0003152 ! increased protein level during cellular response to heat is_a: FYPO:0004180 ! increased cellular protein aggregate level created_by: midori creation_date: 2015-08-11T15:18:43Z [Term] id: FYPO:0004809 name: decreased duration of heterochromatin maintenance involved in chromatin silencing at centromere outer repeat def: "A cellular process phenotype observed in the vegetative growth phase of the life cycle in in which the duration of heterochromatin maintenance is decreased in the context of chromatin silencing at centromere outer repeat regions." [GO:1902368, PMID:25543137, PomBase:mah] synonym: "decreased duration of heterochromatin maintenance involved in chromatin silencing at centromere otr" EXACT [PomBase:mah] synonym: "decreased duration of heterochromatin maintenance involved in chromatin silencing at centromere outer repeat during mitotic cell cycle" RELATED [PomBase:mah] synonym: "decreased duration of heterochromatin maintenance involved in chromatin silencing at centromere outer repeat during vegetative growth" EXACT [PomBase:mah] synonym: "decreased duration of heterochromatin maintenance involved in chromatin silencing at centromere outer repeat region" EXACT [GO:1902368, PomBase:mah] synonym: "decreased duration of heterochromatin maintenance involved in chromatin silencing at pericentric region" RELATED [PomBase:mah] synonym: "decreased duration of heterochromatin maintenance involved in chromatin silencing at pericentromeric region" RELATED [PomBase:mah] synonym: "reduced duration of heterochromatin maintenance involved in chromatin silencing at centromere outer repeat" EXACT [PomBase:mah] is_a: FYPO:0004543 ! abnormal heterochromatin organization during vegetative growth is_a: PATO:0000499 ! decreased duration intersection_of: PATO:0000499 ! decreased duration intersection_of: happens_during GO:0072690 ! single-celled organism vegetative growth phase intersection_of: inheres_in GO:1902368 ! heterochromatin maintenance involved in chromatin silencing at centromere outer repeat region relationship: happens_during GO:0072690 ! single-celled organism vegetative growth phase relationship: inheres_in GO:1902368 ! heterochromatin maintenance involved in chromatin silencing at centromere outer repeat region created_by: midori creation_date: 2015-08-11T15:20:50Z [Term] id: FYPO:0004810 name: decreased protein localization to nucleus, with protein mislocalized to cytoplasmic foci def: "A cell phenotype observed in the vegetative growth phase of the life cycle in which the localization of a protein to the nucleus is decreased, and the protein is instead visible in one or a few foci or dots in the cytoplasm." [PMID:25543137, PomBase:mah] comment: We recommend noting which protein(s) were used in the assay when annotating to this term. synonym: "decreased protein localisation to nucleus, with protein mislocalised to cytoplasmic foci" EXACT [PomBase:mah] synonym: "decreased protein localization to nucleus, with protein mislocalized to cytoplasmic foci, during mitotic interphase" EXACT [PomBase:mah] synonym: "decreased protein localization to nucleus, with protein mislocalized to cytoplasmic foci, during vegetative growth" EXACT [PomBase:mah] is_a: FYPO:0004056 ! decreased protein localization to nucleus, with protein mislocalized to cytoplasm created_by: midori creation_date: 2015-08-11T15:23:29Z [Term] id: GO:0000001 name: mitochondrion inheritance namespace: biological_process def: "The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:11389764] synonym: "mitochondrial inheritance" EXACT [] is_a: GO:0048308 ! organelle inheritance is_a: GO:0048311 ! mitochondrion distribution property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000002 name: mitochondrial genome maintenance namespace: biological_process def: "The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome." [GOC:ai, GOC:vw] is_a: GO:0007005 ! mitochondrion organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000003 name: reproduction namespace: biological_process alt_id: GO:0019952 alt_id: GO:0050876 def: "The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms." [GOC:go_curators, GOC:isa_complete, GOC:jl, ISBN:0198506732] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "reproductive physiological process" EXACT [] xref: Wikipedia:Reproduction is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000022 name: mitotic spindle elongation namespace: biological_process def: "The cell cycle process in which the distance is lengthened between poles of the spindle. Spindle elongation begins during prophase and ends during anaphase B." [GOC:mtg_cell_cycle, GOC:vw] synonym: "spindle elongation during mitosis" EXACT [] is_a: GO:0051231 ! spindle elongation is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0051231 ! spindle elongation intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0007052 ! mitotic spindle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000023 name: maltose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose), an intermediate in the catabolism of glycogen and starch." [GOC:jl, ISBN:0198506732] subset: gosubset_prok synonym: "malt sugar metabolic process" EXACT [] synonym: "malt sugar metabolism" EXACT [] synonym: "maltose metabolism" EXACT [] is_a: GO:0005984 ! disaccharide metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000041 name: transition metal ion transport namespace: biological_process def: "The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732] subset: gosubset_prok synonym: "transition metal transport" EXACT [] is_a: GO:0030001 ! metal ion transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000070 name: mitotic sister chromatid segregation namespace: biological_process alt_id: GO:0016359 def: "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl] synonym: "mitotic chromosome segregation" EXACT [] synonym: "mitotic sister-chromatid adhesion release" NARROW [] is_a: GO:0000819 ! sister chromatid segregation is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0098813 ! nuclear chromosome segregation intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0007067 ! mitotic nuclear division property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000073 name: spindle pole body separation namespace: biological_process alt_id: GO:0030475 def: "A largely uncharacterized process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that may be severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar mitotic spindle to assemble." [GOC:sgd_curators] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0051300 ! spindle pole body organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000075 name: cell cycle checkpoint namespace: biological_process alt_id: GO:0031576 alt_id: GO:0071779 def: "A cell cycle process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction." [GOC:mtg_cell_cycle] comment: This term should not be used in direct manual annotation as it should always be possible to minimally designate mitotic or meiotic checkpoint, and usually to additionally specify the checkpoint (i.e mitotic spindle assembly checkpoint, mitotic DNA damage checkpoint etc). Note also that the effector processes are not part of the checkpoint but are positively regulated by the checkpoint signaling and should not be annotated here. subset: gocheck_do_not_manually_annotate synonym: "G1/S checkpoint" NARROW [] synonym: "G1/S transition checkpoint" NARROW [] synonym: "G2/M checkpoint" NARROW [] synonym: "G2/M transition checkpoint" NARROW [] xref: Reactome:REACT_100401 "Cell Cycle Checkpoints, Gallus gallus" xref: Reactome:REACT_102145 "Cell Cycle Checkpoints, Saccharomyces cerevisiae" xref: Reactome:REACT_102175 "Cell Cycle Checkpoints, Canis familiaris" xref: Reactome:REACT_106487 "Cell Cycle Checkpoints, Rattus norvegicus" xref: Reactome:REACT_109101 "Cell Cycle Checkpoints, Drosophila melanogaster" xref: Reactome:REACT_1538 "Cell Cycle Checkpoints, Homo sapiens" xref: Reactome:REACT_29957 "Cell Cycle Checkpoints, Bos taurus" xref: Reactome:REACT_31789 "Cell Cycle Checkpoints, Dictyostelium discoideum" xref: Reactome:REACT_33305 "Cell Cycle Checkpoints, Oryza sativa" xref: Reactome:REACT_79078 "Cell Cycle Checkpoints, Sus scrofa" xref: Reactome:REACT_84460 "Cell Cycle Checkpoints, Arabidopsis thaliana" xref: Reactome:REACT_89660 "Cell Cycle Checkpoints, Xenopus tropicalis" xref: Reactome:REACT_90285 "Cell Cycle Checkpoints, Mus musculus" xref: Reactome:REACT_90465 "Cell Cycle Checkpoints, Caenorhabditis elegans" xref: Reactome:REACT_92239 "Cell Cycle Checkpoints, Danio rerio" xref: Reactome:REACT_96499 "Cell Cycle Checkpoints, Taeniopygia guttata" xref: Reactome:REACT_99737 "Cell Cycle Checkpoints, Schizosaccharomyces pombe" xref: Wikipedia:Cell_cycle_checkpoint is_a: GO:0022402 ! cell cycle process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000076 name: DNA replication checkpoint namespace: biological_process def: "A cell cycle checkpoint that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:curators, GOC:rn, PMID:11728327, PMID:12537518] is_a: GO:0031570 ! DNA integrity checkpoint property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000077 name: DNA damage checkpoint namespace: biological_process def: "A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds." [GOC:mtg_cell_cycle] synonym: "DNA damage response, signal transduction resulting in cell cycle arrest" NARROW [] xref: Wikipedia:DNA_damage_checkpoint xref: Wikipedia:Postreplication_checkpoint is_a: GO:0006974 ! cellular response to DNA damage stimulus is_a: GO:0031570 ! DNA integrity checkpoint property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000080 name: mitotic G1 phase namespace: biological_process def: "The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "G1 phase of mitotic cell cycle" EXACT [] xref: Reactome:REACT_101162 "G1 Phase, Bos taurus" xref: Reactome:REACT_1590 "G1 Phase, Homo sapiens" xref: Reactome:REACT_29795 "G1 Phase, Taeniopygia guttata" xref: Reactome:REACT_34060 "G1 Phase, Canis familiaris" xref: Reactome:REACT_78665 "G1 Phase, Gallus gallus" xref: Reactome:REACT_78866 "G1 Phase, Sus scrofa" xref: Reactome:REACT_83686 "G1 Phase, Danio rerio" xref: Reactome:REACT_91654 "G1 Phase, Mus musculus" xref: Reactome:REACT_93384 "G1 Phase, Rattus norvegicus" xref: Reactome:REACT_93574 "G1 Phase, Xenopus tropicalis" is_a: GO:0051318 ! G1 phase is_a: GO:0098763 ! mitotic cell cycle phase relationship: part_of GO:0051329 ! mitotic interphase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000082 name: G1/S transition of mitotic cell cycle namespace: biological_process def: "The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle] xref: Reactome:REACT_101799 "G1/S Transition, Taeniopygia guttata" xref: Reactome:REACT_102687 "G1/S Transition, Arabidopsis thaliana" xref: Reactome:REACT_104020 "G1/S Transition, Canis familiaris" xref: Reactome:REACT_104529 "G1/S Transition, Schizosaccharomyces pombe" xref: Reactome:REACT_104577 "G1/S Transition, Saccharomyces cerevisiae" xref: Reactome:REACT_106054 "G1/S Transition, Mus musculus" xref: Reactome:REACT_107492 "G1/S Transition, Dictyostelium discoideum" xref: Reactome:REACT_109784 "G1/S Transition, Oryza sativa" xref: Reactome:REACT_109821 "G1/S Transition, Danio rerio" xref: Reactome:REACT_110917 "G1/S Transition, Plasmodium falciparum" xref: Reactome:REACT_1783 "G1/S Transition, Homo sapiens" xref: Reactome:REACT_28713 "G1/S Transition, Xenopus tropicalis" xref: Reactome:REACT_45711 "G1/S Transition, Caenorhabditis elegans" xref: Reactome:REACT_84226 "G1/S Transition, Gallus gallus" xref: Reactome:REACT_85355 "G1/S Transition, Sus scrofa" xref: Reactome:REACT_87037 "G1/S Transition, Drosophila melanogaster" xref: Reactome:REACT_88046 "G1/S Transition, Bos taurus" xref: Reactome:REACT_95294 "G1/S Transition, Rattus norvegicus" is_a: GO:0044772 ! mitotic cell cycle phase transition is_a: GO:0044843 ! cell cycle G1/S phase transition property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000083 name: regulation of transcription involved in G1/S transition of mitotic cell cycle namespace: biological_process def: "Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] xref: Reactome:REACT_683 "G1/S-Specific Transcription, Homo sapiens" is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0006357 ! regulation of transcription from RNA polymerase II promoter intersection_of: part_of GO:0000082 ! G1/S transition of mitotic cell cycle relationship: part_of GO:0000082 ! G1/S transition of mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000084 name: mitotic S phase namespace: biological_process def: "The cell cycle phase, following G1, during which DNA synthesis takes place as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "S phase of mitotic cell cycle" EXACT [] synonym: "S-phase of mitotic cell cycle" EXACT [] xref: Reactome:REACT_105829 "S Phase, Caenorhabditis elegans" xref: Reactome:REACT_108550 "S Phase, Rattus norvegicus" xref: Reactome:REACT_110039 "S Phase, Schizosaccharomyces pombe" xref: Reactome:REACT_28988 "S Phase, Taeniopygia guttata" xref: Reactome:REACT_32013 "S Phase, Mycobacterium tuberculosis" xref: Reactome:REACT_34043 "S Phase, Oryza sativa" xref: Reactome:REACT_78838 "S Phase, Plasmodium falciparum" xref: Reactome:REACT_78845 "S Phase, Xenopus tropicalis" xref: Reactome:REACT_81914 "S Phase, Saccharomyces cerevisiae" xref: Reactome:REACT_82813 "S Phase, Arabidopsis thaliana" xref: Reactome:REACT_85811 "S Phase, Sus scrofa" xref: Reactome:REACT_89318 "S Phase, Drosophila melanogaster" xref: Reactome:REACT_899 "S Phase, Homo sapiens" xref: Reactome:REACT_92500 "S Phase, Mus musculus" xref: Reactome:REACT_92759 "S Phase, Canis familiaris" xref: Reactome:REACT_95174 "S Phase, Gallus gallus" xref: Reactome:REACT_96081 "S Phase, Dictyostelium discoideum" xref: Reactome:REACT_97603 "S Phase, Danio rerio" xref: Reactome:REACT_99645 "S Phase, Bos taurus" is_a: GO:0051320 ! S phase is_a: GO:0098763 ! mitotic cell cycle phase relationship: part_of GO:0051329 ! mitotic interphase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000085 name: mitotic G2 phase namespace: biological_process def: "The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by mitosis." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "G2 phase of mitotic cell cycle" EXACT [] xref: Reactome:REACT_105223 "G2 Phase, Mus musculus" xref: Reactome:REACT_105307 "G2 Phase, Canis familiaris" xref: Reactome:REACT_106415 "G2 Phase, Xenopus tropicalis" xref: Reactome:REACT_106836 "G2 Phase, Bos taurus" xref: Reactome:REACT_1915 "G2 Phase, Homo sapiens" xref: Reactome:REACT_28975 "G2 Phase, Rattus norvegicus" xref: Reactome:REACT_85928 "G2 Phase, Sus scrofa" xref: Reactome:REACT_96332 "G2 Phase, Danio rerio" is_a: GO:0051319 ! G2 phase is_a: GO:0098763 ! mitotic cell cycle phase relationship: part_of GO:0051329 ! mitotic interphase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000086 name: G2/M transition of mitotic cell cycle namespace: biological_process def: "The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex." [GOC:mtg_cell_cycle] synonym: "mitotic G2/M transition" EXACT [] xref: Reactome:REACT_100942 "G2/M Transition, Danio rerio" xref: Reactome:REACT_103766 "G2/M Transition, Schizosaccharomyces pombe" xref: Reactome:REACT_107882 "G2/M Transition, Sus scrofa" xref: Reactome:REACT_114616 "G2/M Transition, Arabidopsis thaliana" xref: Reactome:REACT_2203 "G2/M Transition, Homo sapiens" xref: Reactome:REACT_28929 "G2/M Transition, Xenopus tropicalis" xref: Reactome:REACT_30388 "G2/M Transition, Gallus gallus" xref: Reactome:REACT_34062 "G2/M Transition, Mus musculus" xref: Reactome:REACT_77778 "G2/M Transition, Taeniopygia guttata" xref: Reactome:REACT_83880 "G2/M Transition, Drosophila melanogaster" xref: Reactome:REACT_87036 "G2/M Transition, Saccharomyces cerevisiae" xref: Reactome:REACT_87230 "G2/M Transition, Canis familiaris" xref: Reactome:REACT_87807 "G2/M Transition, Dictyostelium discoideum" xref: Reactome:REACT_88018 "G2/M Transition, Caenorhabditis elegans" xref: Reactome:REACT_88369 "G2/M Transition, Rattus norvegicus" xref: Reactome:REACT_92702 "G2/M Transition, Bos taurus" is_a: GO:0044772 ! mitotic cell cycle phase transition is_a: GO:0044839 ! cell cycle G2/M phase transition intersection_of: GO:0044839 ! cell cycle G2/M phase transition intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000278 ! mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000087 name: mitotic M phase namespace: biological_process def: "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "M phase of mitotic cell cycle" EXACT [] synonym: "M-phase of mitotic cell cycle" EXACT [] xref: Reactome:REACT_105412 "M Phase, Mus musculus" xref: Reactome:REACT_107095 "M Phase, Dictyostelium discoideum" xref: Reactome:REACT_109059 "M Phase, Saccharomyces cerevisiae" xref: Reactome:REACT_29488 "M Phase, Canis familiaris" xref: Reactome:REACT_33490 "M Phase, Caenorhabditis elegans" xref: Reactome:REACT_82055 "M Phase, Rattus norvegicus" xref: Reactome:REACT_87132 "M Phase, Bos taurus" xref: Reactome:REACT_88263 "M Phase, Xenopus tropicalis" xref: Reactome:REACT_910 "M Phase, Homo sapiens" xref: Reactome:REACT_92998 "M Phase, Danio rerio" xref: Reactome:REACT_93131 "M Phase, Schizosaccharomyces pombe" xref: Reactome:REACT_93566 "M Phase, Gallus gallus" xref: Reactome:REACT_93720 "M Phase, Drosophila melanogaster" xref: Reactome:REACT_94536 "M Phase, Taeniopygia guttata" is_a: GO:0000279 ! M phase is_a: GO:0098763 ! mitotic cell cycle phase intersection_of: GO:0000279 ! M phase intersection_of: happens_during GO:0000278 ! mitotic cell cycle relationship: happens_during GO:0000278 ! mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000088 name: mitotic prophase namespace: biological_process def: "The cell cycle phase which is the first stage of M phase of mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Reactome:REACT_100605 "Mitotic Prophase, Saccharomyces cerevisiae" xref: Reactome:REACT_102122 "Mitotic Prophase, Mus musculus" xref: Reactome:REACT_105127 "Mitotic Prophase, Danio rerio" xref: Reactome:REACT_106058 "Mitotic Prophase, Drosophila melanogaster" xref: Reactome:REACT_28443 "Mitotic Prophase, Taeniopygia guttata" xref: Reactome:REACT_28607 "Mitotic Prophase, Rattus norvegicus" xref: Reactome:REACT_32677 "Mitotic Prophase, Xenopus tropicalis" xref: Reactome:REACT_765 "Mitotic Prophase, Homo sapiens" xref: Reactome:REACT_79474 "Mitotic Prophase, Caenorhabditis elegans" xref: Reactome:REACT_80300 "Mitotic Prophase, Gallus gallus" xref: Reactome:REACT_83888 "Mitotic Prophase, Dictyostelium discoideum" xref: Reactome:REACT_90347 "Mitotic Prophase, Canis familiaris" xref: Reactome:REACT_90481 "Mitotic Prophase, Schizosaccharomyces pombe" is_a: GO:0051324 ! prophase is_a: GO:0098763 ! mitotic cell cycle phase relationship: part_of GO:0000087 ! mitotic M phase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000089 name: mitotic metaphase namespace: biological_process def: "The cell cycle phase, following prophase, during which chromosomes become aligned on the equatorial plate of the cell as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Reactome:REACT_434 "Mitotic Metaphase, Homo sapiens" is_a: GO:0051323 ! metaphase is_a: GO:0098763 ! mitotic cell cycle phase relationship: part_of GO:0000087 ! mitotic M phase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000090 name: mitotic anaphase namespace: biological_process def: "The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Reactome:REACT_1275 "Mitotic Anaphase, Homo sapiens" is_a: GO:0051322 ! anaphase is_a: GO:0098763 ! mitotic cell cycle phase relationship: part_of GO:0000087 ! mitotic M phase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000091 name: mitotic anaphase A namespace: biological_process def: "The cell cycle phase during which the kinetochore microtubules shorten as chromosomes move toward the spindle poles as part of mitosis." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0000090 ! mitotic anaphase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000092 name: mitotic anaphase B namespace: biological_process def: "The cell cycle phase during which the polar microtubules elongate and the two poles of the spindle move farther apart as part of mitosis." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0000090 ! mitotic anaphase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000093 name: mitotic telophase namespace: biological_process def: "The cell cycle phase which follows anaphase during M phase of mitosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051326 ! telophase is_a: GO:0098763 ! mitotic cell cycle phase relationship: part_of GO:0000087 ! mitotic M phase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000096 name: sulfur amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine." [GOC:ai] subset: gosubset_prok synonym: "sulfur amino acid metabolism" EXACT [] synonym: "sulphur amino acid metabolic process" EXACT [] synonym: "sulphur amino acid metabolism" EXACT [] xref: Reactome:REACT_115639 "Sulfur amino acid metabolism, Homo sapiens" xref: Reactome:REACT_118084 "Sulfur amino acid metabolism, Rattus norvegicus" xref: Reactome:REACT_118094 "Sulfur amino acid metabolism, Bos taurus" xref: Reactome:REACT_118099 "Sulfur amino acid metabolism, Escherichia coli" xref: Reactome:REACT_118166 "Sulfur amino acid metabolism, Taeniopygia guttata" xref: Reactome:REACT_118184 "Sulfur amino acid metabolism, Canis familiaris" xref: Reactome:REACT_118203 "Sulfur amino acid metabolism, Sus scrofa" xref: Reactome:REACT_118227 "Sulfur amino acid metabolism, Mycobacterium tuberculosis" xref: Reactome:REACT_118256 "Sulfur amino acid metabolism, Staphylococcus aureus N315" xref: Reactome:REACT_118291 "Sulfur amino acid metabolism, Caenorhabditis elegans" xref: Reactome:REACT_118309 "Sulfur amino acid metabolism, Gallus gallus" xref: Reactome:REACT_118314 "Sulfur amino acid metabolism, Arabidopsis thaliana" xref: Reactome:REACT_118323 "Sulfur amino acid metabolism, Xenopus tropicalis" xref: Reactome:REACT_118328 "Sulfur amino acid metabolism, Drosophila melanogaster" xref: Reactome:REACT_118349 "Sulfur amino acid metabolism, Oryza sativa" xref: Reactome:REACT_118370 "Sulfur amino acid metabolism, Mus musculus" xref: Reactome:REACT_118388 "Sulfur amino acid metabolism, Saccharomyces cerevisiae" xref: Reactome:REACT_118463 "Sulfur amino acid metabolism, Schizosaccharomyces pombe" xref: Reactome:REACT_118518 "Sulfur amino acid metabolism, Dictyostelium discoideum" xref: Reactome:REACT_118541 "Sulfur amino acid metabolism, Danio rerio" xref: Reactome:REACT_27187 "Sulfur amino acid metabolism, Mycobacterium tuberculosis" is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000097 name: sulfur amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine." [GOC:ai] subset: gosubset_prok synonym: "sulfur amino acid anabolism" EXACT [] synonym: "sulfur amino acid biosynthesis" EXACT [] synonym: "sulfur amino acid formation" EXACT [] synonym: "sulfur amino acid synthesis" EXACT [] synonym: "sulphur amino acid biosynthesis" EXACT [] synonym: "sulphur amino acid biosynthetic process" EXACT [] is_a: GO:0000096 ! sulfur amino acid metabolic process is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000101 name: sulfur amino acid transport namespace: biological_process def: "The directed movement of amino acids containing sulfur (cystine, methionine and their derivatives) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "sulphur amino acid transport" EXACT [] is_a: GO:0006865 ! amino acid transport is_a: GO:0072348 ! sulfur compound transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000104 name: succinate dehydrogenase activity namespace: molecular_function alt_id: GO:0019739 def: "Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor." [EC:1.3.99.1, GOC:kd] subset: gosubset_prok synonym: "fumarate dehydrogenase activity" EXACT [EC:1.3.99.1] synonym: "fumarate reductase activity" EXACT [EC:1.3.99.1] synonym: "fumaric hydrogenase activity" EXACT [EC:1.3.99.1] synonym: "succinate oxidoreductase activity" EXACT [EC:1.3.99.1] synonym: "succinate:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.1] synonym: "succinate:acceptor oxidoreductase activity" EXACT [EC:1.3.99.1] synonym: "succinic acid dehydrogenase activity" EXACT [EC:1.3.99.1] synonym: "succinic dehydrogenase activity" BROAD [EC:1.3.99.1] synonym: "succinodehydrogenase activity" EXACT [EC:1.3.99.1] synonym: "succinyl dehydrogenase activity" EXACT [EC:1.3.99.1] xref: EC:1.3.99.1 xref: MetaCyc:SUCC-FUM-OXRED-RXN xref: RHEA:16360 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000122 name: negative regulation of transcription from RNA polymerase II promoter namespace: biological_process alt_id: GO:0010553 alt_id: GO:0045816 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] synonym: "down regulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "down regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "down-regulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "down-regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "downregulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "downregulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "inhibition of global transcription from RNA polymerase II promoter" RELATED [] synonym: "inhibition of transcription from RNA polymerase II promoter" EXACT [] synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [] synonym: "negative regulation of global transcription from Pol II promoter" RELATED [] synonym: "negative regulation of transcription from Pol II promoter" EXACT [] synonym: "negative regulation of transcription from RNA polymerase II promoter, global" RELATED [] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0045892 ! negative regulation of transcription, DNA-templated intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006366 ! transcription from RNA polymerase II promoter relationship: negatively_regulates GO:0006366 ! transcription from RNA polymerase II promoter property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000128 name: flocculation namespace: biological_process def: "The reversible, non-sexual aggregation of single-celled organisms in suspension to form aggregates of many cells known as flocs." [GOC:jl, GOC:vw, PMID:21114594, PMID:8740415] comment: The word floc derives from the Latin word floccus, which means a tuft of wool. subset: goslim_pir subset: gosubset_prok xref: Wikipedia:Flocculation is_a: GO:0098630 ! aggregation of unicellular organisms property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000147 name: actin cortical patch assembly namespace: biological_process def: "Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells." [GOC:mah] is_a: GO:0022607 ! cellular component assembly is_a: GO:0030866 ! cortical actin cytoskeleton organization is_a: GO:0044396 ! actin cortical patch organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000165 name: MAPK cascade namespace: biological_process def: "An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:mtg_signaling_feb11, PMID:20811974, PMID:9561267] comment: MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier. synonym: "ERK/MAPK cascade" NARROW [] synonym: "MAP kinase cascade" EXACT [] synonym: "MAP kinase kinase kinase cascade" EXACT [] synonym: "MAPK signal transduction" EXACT [GOC:signaling] synonym: "MAPK signaling" RELATED [] synonym: "MAPK signalling" RELATED [] synonym: "MAPKKK cascade" EXACT [GOC:curators] synonym: "MAPKKK cascade during sporulation" NARROW [] synonym: "mitogen-activated protein kinase cascade" EXACT [GOC:bf] xref: Reactome:REACT_101634 "RAF/MAP kinase cascade, Bos taurus" xref: Reactome:REACT_107261 "RAF/MAP kinase cascade, Saccharomyces cerevisiae" xref: Reactome:REACT_107863 "RAF/MAP kinase cascade, Canis familiaris" xref: Reactome:REACT_108330 "RAF/MAP kinase cascade, Xenopus tropicalis" xref: Reactome:REACT_112235 "RAF/MAP kinase cascade, Dictyostelium discoideum" xref: Reactome:REACT_112942 "RAF/MAP kinase cascade, Arabidopsis thaliana" xref: Reactome:REACT_113285 "RAF/MAP kinase cascade, Oryza sativa" xref: Reactome:REACT_634 "RAF/MAP kinase cascade, Homo sapiens" xref: Reactome:REACT_79658 "RAF/MAP kinase cascade, Schizosaccharomyces pombe" xref: Reactome:REACT_85806 "RAF/MAP kinase cascade, Drosophila melanogaster" xref: Reactome:REACT_87028 "RAF/MAP kinase cascade, Danio rerio" xref: Reactome:REACT_87232 "RAF/MAP kinase cascade, Mus musculus" xref: Reactome:REACT_87855 "RAF/MAP kinase cascade, Rattus norvegicus" xref: Reactome:REACT_92078 "RAF/MAP kinase cascade, Sus scrofa" xref: Reactome:REACT_92987 "RAF/MAP kinase cascade, Caenorhabditis elegans" xref: Reactome:REACT_94585 "RAF/MAP kinase cascade, Taeniopygia guttata" xref: Reactome:REACT_94805 "RAF/MAP kinase cascade, Gallus gallus" xref: Wikipedia:MAPK_cascade xref: Wikipedia:Mitogen-activated_protein_kinase is_a: GO:0023014 ! signal transduction by protein phosphorylation is_a: GO:0035556 ! intracellular signal transduction property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000166 name: nucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: gosubset_prok is_a: GO:0036094 ! small molecule binding is_a: GO:1901265 ! nucleoside phosphate binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000175 name: 3'-5'-exoribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684] subset: gosubset_prok synonym: "3'-5' exoribonuclease activity" EXACT [] xref: EC:3.1.13.- xref: Reactome:REACT_102966 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Schizosaccharomyces pombe" xref: Reactome:REACT_108214 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Sus scrofa" xref: Reactome:REACT_20588 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Homo sapiens" xref: Reactome:REACT_33991 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Dictyostelium discoideum" xref: Reactome:REACT_34078 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Danio rerio" xref: Reactome:REACT_78363 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Bos taurus" xref: Reactome:REACT_82118 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Rattus norvegicus" xref: Reactome:REACT_88115 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Arabidopsis thaliana" xref: Reactome:REACT_89880 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Oryza sativa" xref: Reactome:REACT_92153 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Caenorhabditis elegans" xref: Reactome:REACT_93499 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Drosophila melanogaster" xref: Reactome:REACT_95913 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Canis familiaris" xref: Reactome:REACT_95921 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Mus musculus" xref: Reactome:REACT_96267 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Taeniopygia guttata" xref: Reactome:REACT_99422 "3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex, Xenopus tropicalis" is_a: GO:0008408 ! 3'-5' exonuclease activity is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000183 name: chromatin silencing at rDNA namespace: biological_process def: "Repression of transcription of ribosomal DNA by altering the structure of chromatin." [PMID:10219245] synonym: "chromatin silencing at ribosomal DNA" EXACT [] synonym: "heterochromatic silencing at rDNA" EXACT [] synonym: "rDNA chromatin silencing" EXACT [GOC:mah] is_a: GO:0006342 ! chromatin silencing property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000184 name: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay namespace: biological_process def: "The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395] synonym: "mRNA breakdown, nonsense-mediated decay" EXACT [] synonym: "mRNA catabolic process, nonsense-mediated" EXACT [] synonym: "mRNA catabolism, nonsense-mediated" EXACT [] synonym: "mRNA degradation, nonsense-mediated decay" EXACT [] synonym: "nonsense-mediated mRNA decay" EXACT [] synonym: "nuclear mRNA catabolic process, nonsense-mediated decay" EXACT [] xref: Reactome:REACT_75886 "Nonsense-Mediated Decay, Homo sapiens" xref: Wikipedia:Nonsense-mediated_decay xref: Wikipedia:Nonsense-mediated_mRNA_decay is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000196 name: MAPK cascade involved in cell wall organization or biogenesis namespace: biological_process def: "A MAPK cascade that contributes to cell wall organization or biogenesis." [PMID:9561267] synonym: "cell integrity MAPK pathway" EXACT [GOC:vw, PMID:23934882] synonym: "cell wall biogenesis, MAPKKK cascade" EXACT [] synonym: "MAPK cascade involved in cell wall biogenesis" NARROW [GOC:vw] synonym: "MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:signaling] synonym: "Mpk1 cascade" NARROW [PMID:10523653] synonym: "Pmk1 MAPK cell integrity signaling" NARROW [PMID:20032302] synonym: "Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [PMID:23934882] synonym: "PMK1-MAPK signal transduction pathway" NARROW [PMID:23454094] synonym: "Slt2 cascade" NARROW [PMID:10523653] is_a: GO:0000165 ! MAPK cascade intersection_of: GO:0000165 ! MAPK cascade intersection_of: part_of GO:0071554 ! cell wall organization or biogenesis relationship: part_of GO:0071554 ! cell wall organization or biogenesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000209 name: protein polyubiquitination namespace: biological_process def: "Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194] synonym: "polyubiquitin" RELATED [] synonym: "protein polyubiquitinylation" EXACT [] synonym: "protein polyubiquitylation" EXACT [] xref: Reactome:REACT_75842 "Antigen processing: Ubiquitination & Proteasome degradation, Homo sapiens" is_a: GO:0016567 ! protein ubiquitination property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000212 name: meiotic spindle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle." [GOC:mah] synonym: "meiotic spindle organisation" EXACT [GOC:curators] synonym: "meiotic spindle organization and biogenesis" RELATED [GOC:mah] synonym: "spindle organization during meiosis" EXACT [GOC:mah] is_a: GO:0007051 ! spindle organization is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0007051 ! spindle organization intersection_of: part_of GO:0051321 ! meiotic cell cycle relationship: part_of GO:0051321 ! meiotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000224 name: peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity namespace: molecular_function def: "Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue." [EC:3.5.1.52] subset: gosubset_prok synonym: "glycopeptidase activity" BROAD [EC:3.5.1.52] synonym: "glycopeptide N-glycosidase activity" BROAD [EC:3.5.1.52] synonym: "jack-bean glycopeptidase" NARROW [EC:3.5.1.52] synonym: "N-glycanase activity" RELATED [EC:3.5.1.52] synonym: "N-linked-glycopeptide-(N-acetyl-beta-D-glucosaminyl)-L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.52] synonym: "N-oligosaccharide glycopeptidase activity" RELATED [EC:3.5.1.52] synonym: "peptide:N-glycanase" RELATED [] synonym: "PNGase" EXACT [] synonym: "PNGase A" RELATED [EC:3.5.1.52] synonym: "PNGase F" RELATED [EC:3.5.1.52] xref: EC:3.5.1.52 xref: MetaCyc:3.5.1.52-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000226 name: microtubule cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] synonym: "microtubule cytoskeleton organisation" EXACT [GOC:mah] synonym: "microtubule cytoskeleton organization and biogenesis" RELATED [GOC:mah] synonym: "microtubule dynamics" EXACT [GOC:dph, GOC:tb] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0007017 ! microtubule-based process is_a: GO:1902589 ! single-organism organelle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000228 name: nuclear chromosome namespace: cellular_component def: "A chromosome found in the nucleus of a eukaryotic cell." [GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "nuclear interphase chromosome" NARROW [] is_a: GO:0005694 ! chromosome is_a: GO:0044428 ! nuclear part intersection_of: GO:0005694 ! chromosome intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0005634 ! nucleus relationship: part_of GO:0031981 ! nuclear lumen property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000235 name: astral microtubule namespace: cellular_component def: "Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [ISBN:0815316194] is_a: GO:0005876 ! spindle microtubule is_a: GO:0005881 ! cytoplasmic microtubule intersection_of: GO:0005876 ! spindle microtubule intersection_of: part_of GO:0005818 ! aster relationship: part_of GO:0005818 ! aster property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000236 name: mitotic prometaphase namespace: biological_process def: "The cell cycle phase in higher eukaryotes which follows mitotic prophase and during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Reactome:REACT_102823 "Mitotic Prometaphase, Mus musculus" xref: Reactome:REACT_104270 "Mitotic Prometaphase, Bos taurus" xref: Reactome:REACT_105082 "Mitotic Prometaphase, Dictyostelium discoideum" xref: Reactome:REACT_114704 "Mitotic Prometaphase, Schizosaccharomyces pombe" xref: Reactome:REACT_118069 "Mitotic Prometaphase, Gallus gallus" xref: Reactome:REACT_118526 "Mitotic Prometaphase, Saccharomyces cerevisiae" xref: Reactome:REACT_118539 "Mitotic Prometaphase, Taeniopygia guttata" xref: Reactome:REACT_31336 "Mitotic Prometaphase, Danio rerio" xref: Reactome:REACT_31385 "Mitotic Prometaphase, Caenorhabditis elegans" xref: Reactome:REACT_682 "Mitotic Prometaphase, Homo sapiens" xref: Reactome:REACT_79351 "Mitotic Prometaphase, Rattus norvegicus" xref: Reactome:REACT_83126 "Mitotic Prometaphase, Drosophila melanogaster" xref: Reactome:REACT_98905 "Mitotic Prometaphase, Xenopus tropicalis" xref: Reactome:REACT_99376 "Mitotic Prometaphase, Canis familiaris" is_a: GO:0098763 ! mitotic cell cycle phase relationship: happens_during GO:0000278 ! mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000245 name: spliceosomal complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions." [PMID:9476892] synonym: "spliceosome assembly" BROAD [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000398 ! mRNA splicing, via spliceosome property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000266 name: mitochondrial fission namespace: biological_process def: "The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [PMID:11038192] synonym: "mitochondrial division" EXACT [] synonym: "mitochondrial proliferation" RELATED [] is_a: GO:0007005 ! mitochondrion organization is_a: GO:0048285 ! organelle fission property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000271 name: polysaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:go_curators] subset: gosubset_prok synonym: "glycan biosynthesis" EXACT [] synonym: "glycan biosynthetic process" EXACT [] synonym: "polysaccharide anabolism" EXACT [] synonym: "polysaccharide biosynthesis" EXACT [] synonym: "polysaccharide formation" EXACT [] synonym: "polysaccharide synthesis" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0016051 ! carbohydrate biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000272 name: polysaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:go_curators] subset: gosubset_prok synonym: "polysaccharide breakdown" EXACT [] synonym: "polysaccharide catabolism" EXACT [] synonym: "polysaccharide degradation" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0016052 ! carbohydrate catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000278 name: mitotic cell cycle namespace: biological_process def: "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278] subset: goslim_yeast xref: Reactome:REACT_100451 "Cell Cycle, Mitotic, Taeniopygia guttata" xref: Reactome:REACT_104035 "Cell Cycle, Mitotic, Sus scrofa" xref: Reactome:REACT_104195 "Cell Cycle, Mitotic, Canis familiaris" xref: Reactome:REACT_105856 "Cell Cycle, Mitotic, Danio rerio" xref: Reactome:REACT_108233 "Cell Cycle, Mitotic, Saccharomyces cerevisiae" xref: Reactome:REACT_152 "Cell Cycle, Mitotic, Homo sapiens" xref: Reactome:REACT_28464 "Cell Cycle, Mitotic, Xenopus tropicalis" xref: Reactome:REACT_28953 "Cell Cycle, Mitotic, Bos taurus" xref: Reactome:REACT_33388 "Cell Cycle, Mitotic, Rattus norvegicus" xref: Reactome:REACT_53493 "Cell Cycle, Mitotic, Plasmodium falciparum" xref: Reactome:REACT_79085 "Cell Cycle, Mitotic, Schizosaccharomyces pombe" xref: Reactome:REACT_84794 "Cell Cycle, Mitotic, Caenorhabditis elegans" xref: Reactome:REACT_85137 "Cell Cycle, Mitotic, Gallus gallus" xref: Reactome:REACT_85950 "Cell Cycle, Mitotic, Arabidopsis thaliana" xref: Reactome:REACT_90332 "Cell Cycle, Mitotic, Mus musculus" xref: Reactome:REACT_90846 "Cell Cycle, Mitotic, Oryza sativa" xref: Reactome:REACT_96281 "Cell Cycle, Mitotic, Drosophila melanogaster" xref: Reactome:REACT_97744 "Cell Cycle, Mitotic, Dictyostelium discoideum" xref: Reactome:REACT_98208 "Cell Cycle, Mitotic, Mycobacterium tuberculosis" is_a: GO:0007049 ! cell cycle intersection_of: GO:0007049 ! cell cycle intersection_of: has_part GO:0007067 ! mitotic nuclear division relationship: has_part GO:0007067 ! mitotic nuclear division property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000279 name: M phase namespace: biological_process def: "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "M-phase" EXACT [] xref: Wikipedia:M_phase is_a: GO:0022403 ! cell cycle phase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000280 name: nuclear division namespace: biological_process def: "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." [GOC:mah] subset: goslim_pir synonym: "karyokinesis" RELATED [] is_a: GO:0048285 ! organelle fission property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000281 name: mitotic cytokinesis namespace: biological_process def: "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] subset: goslim_pombe synonym: "cytokinesis after mitosis" EXACT [] is_a: GO:0061640 ! cytoskeleton-dependent cytokinesis is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0061640 ! cytoskeleton-dependent cytokinesis intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000278 ! mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000291 name: nuclear-transcribed mRNA catabolic process, exonucleolytic namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail." [GOC:krc] synonym: "exonucleolytic degradation of mRNA" EXACT [] synonym: "mRNA breakdown, exonucleolytic" EXACT [] synonym: "mRNA degradation, exonucleolytic" EXACT [] synonym: "nuclear mRNA catabolic process, exonucleolytic" EXACT [] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000293 name: ferric-chelate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 Fe2+ + NAD+ = 2 Fe3+ + NADH + H(+)." [EC:1.16.1.7] comment: Note that this function was formerly EC:1.6.99.13. synonym: "Fe(II):NAD+ oxidoreductase activity" EXACT [EC:1.16.1.7] synonym: "ferric chelate reductase activity" EXACT [EC:1.16.1.7] synonym: "iron chelate reductase activity" RELATED [EC:1.16.1.7] synonym: "NADH2:Fe3+ oxidoreductase activity" EXACT [EC:1.16.1.7] synonym: "NADH:Fe(3+) oxidoreductase activity" EXACT [EC:1.16.1.7] synonym: "NADH:Fe(3+)-EDTA reductase activity" EXACT [EC:1.16.1.7] synonym: "NADH:Fe3+ oxidoreductase activity" EXACT [EC:1.16.1.7] synonym: "NADH:Fe3+-EDTA reductase activity" EXACT [EC:1.16.1.7] xref: EC:1.16.1.7 xref: MetaCyc:FERRIC-CHELATE-REDUCTASE-RXN xref: RHEA:15064 is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000302 name: response to reactive oxygen species namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:krc] subset: gosubset_prok synonym: "response to active oxygen species" EXACT [] synonym: "response to AOS" EXACT [] synonym: "response to reactive oxidative species" EXACT [] synonym: "response to reactive oxygen intermediate" EXACT [] synonym: "response to ROI" EXACT [] synonym: "response to ROS" EXACT [] is_a: GO:0006979 ! response to oxidative stress is_a: GO:1901700 ! response to oxygen-containing compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000303 name: response to superoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion." [GOC:krc, ISBN:0198506732] subset: gosubset_prok is_a: GO:0000305 ! response to oxygen radical property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000305 name: response to oxygen radical namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion." [GOC:krc, ISBN:0124325653] subset: gosubset_prok is_a: GO:0000302 ! response to reactive oxygen species is_a: GO:0010035 ! response to inorganic substance property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000320 name: re-entry into mitotic cell cycle namespace: biological_process def: "The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state." [GOC:krc] is_a: GO:0022402 ! cell cycle process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000321 name: re-entry into mitotic cell cycle after pheromone arrest namespace: biological_process def: "The resumption of the mitotic cell division cycle by pheromone-arrested cells that have not mated. An example of this process is found in Saccharomyces cerevisiae." [GOC:krc, PMID:9927449] is_a: GO:0000320 ! re-entry into mitotic cell cycle is_a: GO:0000754 ! adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000322 name: storage vacuole namespace: cellular_component def: "A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules." [GOC:krc] is_a: GO:0005773 ! vacuole property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000323 name: lytic vacuole namespace: cellular_component def: "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc] is_a: GO:0005773 ! vacuole property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000324 name: fungal-type vacuole namespace: cellular_component def: "A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure." [GOC:mah, GOC:mtg_sensu, ISBN:0879693649] synonym: "vacuole, cell cycle-correlated morphology" EXACT [] is_a: GO:0000322 ! storage vacuole is_a: GO:0000323 ! lytic vacuole property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000375 name: RNA splicing, via transesterification reactions namespace: biological_process alt_id: GO:0000385 alt_id: GO:0031202 def: "Splicing of RNA via a series of two transesterification reactions." [GOC:krc] comment: Note that nuclear mRNA, Group I, Group II, and Group III introns are all spliced by a series of two transesterification reactions that occur within the RNA itself, or between two RNAs in trans splicing. Some of these require one or more proteins to stabilize the catalytic conformation, while others are autocatalytic. Note that tRNA introns are spliced by a different catalytic mechanism. subset: gosubset_prok synonym: "pre-mRNA splicing factor activity" RELATED [GOC:krc, GOC:mah] synonym: "RNA splicing factor activity, transesterification mechanism" RELATED [GOC:krc, GOC:mah] synonym: "spliceosomal catalysis" RELATED [] is_a: GO:0008380 ! RNA splicing property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000377 name: RNA splicing, via transesterification reactions with bulged adenosine as nucleophile namespace: biological_process def: "Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure." [GOC:krc, PMID:11377794] subset: gosubset_prok synonym: "lariat RNA biosynthesis" RELATED [] synonym: "lariat RNA formation" RELATED [] is_a: GO:0000375 ! RNA splicing, via transesterification reactions property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000394 name: RNA splicing, via endonucleolytic cleavage and ligation namespace: biological_process def: "Splicing of RNA via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897] comment: Note that while typically associated with tRNA splicing, this mechanism of splicing is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis. subset: gosubset_prok synonym: "mRNA splicing" BROAD [] is_a: GO:0008380 ! RNA splicing property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000398 name: mRNA splicing, via spliceosome namespace: biological_process alt_id: GO:0006374 alt_id: GO:0006375 def: "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] comment: Note that although the many U12-type introns have the sequence AT-AC at the intron termini, some introns with these terminal sequences are spliced by the U2-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron. Note that although the majority of U2-type introns have the sequence GU-AG at the intron termini, some introns with these terminal sequences are spliced by the U12-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron. synonym: "mRNA splicing" BROAD [] synonym: "nuclear mRNA splicing via U12-type spliceosome" NARROW [] synonym: "nuclear mRNA splicing via U2-type spliceosome" NARROW [] synonym: "nuclear mRNA splicing, via spliceosome" EXACT [GOC:krc, GOC:vw] synonym: "pre-mRNA splicing" BROAD [] synonym: "splicing AT-AC intron" RELATED [] synonym: "splicing GT-AG intron" RELATED [] xref: Reactome:REACT_101135 "mRNA Splicing - Minor Pathway, Drosophila melanogaster" xref: Reactome:REACT_101749 "mRNA Splicing - Minor Pathway, Caenorhabditis elegans" xref: Reactome:REACT_106268 "mRNA Splicing - Major Pathway, Gallus gallus" xref: Reactome:REACT_107907 "mRNA Splicing - Minor Pathway, Schizosaccharomyces pombe" xref: Reactome:REACT_109091 "mRNA Splicing - Minor Pathway, Rattus norvegicus" xref: Reactome:REACT_112200 "mRNA Splicing - Major Pathway, Arabidopsis thaliana" xref: Reactome:REACT_114266 "mRNA Splicing - Major Pathway, Oryza sativa" xref: Reactome:REACT_114738 "mRNA Splicing - Major Pathway, Taeniopygia guttata" xref: Reactome:REACT_1753 "mRNA Splicing - Minor Pathway, Homo sapiens" xref: Reactome:REACT_30984 "mRNA Splicing - Minor Pathway, Plasmodium falciparum" xref: Reactome:REACT_32449 "mRNA Splicing - Minor Pathway, Canis familiaris" xref: Reactome:REACT_34020 "mRNA Splicing - Minor Pathway, Dictyostelium discoideum" xref: Reactome:REACT_467 "mRNA Splicing - Major Pathway, Homo sapiens" xref: Reactome:REACT_81417 "mRNA Splicing - Major Pathway, Canis familiaris" xref: Reactome:REACT_82149 "mRNA Splicing - Minor Pathway, Danio rerio" xref: Reactome:REACT_85452 "mRNA Splicing - Major Pathway, Bos taurus" xref: Reactome:REACT_86489 "mRNA Splicing - Minor Pathway, Mus musculus" xref: Reactome:REACT_88186 "mRNA Splicing - Minor Pathway, Oryza sativa" xref: Reactome:REACT_89168 "mRNA Splicing - Minor Pathway, Gallus gallus" xref: Reactome:REACT_90296 "mRNA Splicing - Major Pathway, Danio rerio" xref: Reactome:REACT_91088 "mRNA Splicing - Minor Pathway, Arabidopsis thaliana" xref: Reactome:REACT_91611 "mRNA Splicing - Major Pathway, Drosophila melanogaster" xref: Reactome:REACT_91773 "mRNA Splicing - Minor Pathway, Bos taurus" xref: Reactome:REACT_93740 "mRNA Splicing - Major Pathway, Caenorhabditis elegans" xref: Reactome:REACT_93843 "mRNA Splicing - Major Pathway, Rattus norvegicus" xref: Reactome:REACT_95764 "mRNA Splicing - Major Pathway, Mus musculus" xref: Reactome:REACT_99123 "mRNA Splicing - Major Pathway, Xenopus tropicalis" xref: Reactome:REACT_99763 "mRNA Splicing - Minor Pathway, Xenopus tropicalis" is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile is_a: GO:0006397 ! mRNA processing property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000422 name: mitophagy namespace: biological_process def: "The autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344] synonym: "mitochondrion autophagy" EXACT [GOC:autophagy] xref: Wikipedia:Autophagy_(cellular)#Selective_autophagy xref: Wikipedia:Mitophagy is_a: GO:0007005 ! mitochondrion organization is_a: GO:0016236 ! macroautophagy is_a: GO:0061726 ! mitochondrion disassembly property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000481 name: maturation of 5S rRNA namespace: biological_process def: "Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule." [GOC:curators] is_a: GO:0006364 ! rRNA processing property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000495 name: box H/ACA snoRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a box H/ACA snoRNA molecule." [GOC:krc] synonym: "box H/ACA snoRNA 3' end processing" EXACT [] is_a: GO:0031126 ! snoRNA 3'-end processing is_a: GO:0034964 ! box H/ACA snoRNA processing property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000501 name: flocculation via cell wall protein-carbohydrate interaction namespace: biological_process def: "The reversible, non-sexual aggregation of cells mediated by the binding of proteins in the cell wall of one cell to carbohydrates in the cell wall of another cell. An example of this process is found in Saccharomyces cerevisiae, in which it is pH- and calcium-dependent." [GOC:mcc, GOC:sgd_curators, GOC:vw, PMID:21114594] subset: gosubset_prok is_a: GO:0000128 ! flocculation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000502 name: proteasome complex namespace: cellular_component def: "A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, http://en.wikipedia.org/wiki/Proteasome] subset: goslim_pir synonym: "26S proteasome" NARROW [] synonym: "proteasome" EXACT [GOC:cjm] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000700 name: mismatch base pair DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:9224623] is_a: GO:0019104 ! DNA N-glycosylase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000701 name: purine-specific mismatch base pair DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site." [GOC:elh, PMID:9224623] synonym: "A/G-specific adenine DNA glycosylase activity" NARROW [] xref: EC:3.2.2.- is_a: GO:0000700 ! mismatch base pair DNA N-glycosylase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000714 name: meiotic strand displacement namespace: biological_process def: "The cell cycle process in which the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA is rejected. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. This occurs during meiosis." [GOC:elh, PMID:10357855] synonym: "meiotic D-loop dissociation" RELATED [GOC:mah, GOC:vw] synonym: "meiotic D-loop processing" RELATED [GOC:mah, GOC:vw] synonym: "meiotic displacement loop dissociation" RELATED [GOC:mah, GOC:vw] synonym: "meiotic displacement loop processing" RELATED [GOC:mah, GOC:vw] is_a: GO:0000732 ! strand displacement is_a: GO:0044710 ! single-organism metabolic process is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0000732 ! strand displacement intersection_of: part_of GO:0051321 ! meiotic cell cycle relationship: part_of GO:0007127 ! meiosis I relationship: part_of GO:0051321 ! meiotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000723 name: telomere maintenance namespace: biological_process def: "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831] synonym: "regulation of telomere length" RELATED [GOC:dph, GOC:tb] xref: Reactome:REACT_102051 "Telomere Maintenance, Sus scrofa" xref: Reactome:REACT_102166 "Telomere Maintenance, Schizosaccharomyces pombe" xref: Reactome:REACT_103257 "Telomere Maintenance, Bos taurus" xref: Reactome:REACT_103618 "Telomere Maintenance, Canis familiaris" xref: Reactome:REACT_104398 "Telomere Maintenance, Dictyostelium discoideum" xref: Reactome:REACT_105276 "Disassociation of Processive Complex and Completed Telomere End, Canis familiaris" xref: Reactome:REACT_105401 "Packaging Of Telomere Ends, Rattus norvegicus" xref: Reactome:REACT_105641 "Disassociation of Processive Complex and Completed Telomere End, Mus musculus" xref: Reactome:REACT_107344 "Disassociation of Processive Complex and Completed Telomere End, Xenopus tropicalis" xref: Reactome:REACT_109055 "Disassociation of Processive Complex and Completed Telomere End, Schizosaccharomyces pombe" xref: Reactome:REACT_110319 "Telomere Maintenance, Rattus norvegicus" xref: Reactome:REACT_115102 "Packaging Of Telomere Ends, Canis familiaris" xref: Reactome:REACT_115503 "Packaging Of Telomere Ends, Danio rerio" xref: Reactome:REACT_115535 "Telomere maintenance, Gallus gallus" xref: Reactome:REACT_31996 "Disassociation of Processive Complex and Completed Telomere End, Rattus norvegicus" xref: Reactome:REACT_32322 "Packaging Of Telomere Ends, Sus scrofa" xref: Reactome:REACT_78001 "Telomere Maintenance, Danio rerio" xref: Reactome:REACT_78680 "Telomere Maintenance, Saccharomyces cerevisiae" xref: Reactome:REACT_7954 "Disassociation of Processive Complex and Completed Telomere End, Homo sapiens" xref: Reactome:REACT_7963 "Packaging Of Telomere Ends, Homo sapiens" xref: Reactome:REACT_7970 "Telomere Maintenance, Homo sapiens" xref: Reactome:REACT_80940 "Telomere Maintenance, Plasmodium falciparum" xref: Reactome:REACT_82431 "Disassociation of Processive Complex and Completed Telomere End, Danio rerio" xref: Reactome:REACT_83277 "Disassociation of Processive Complex and Completed Telomere End, Bos taurus" xref: Reactome:REACT_84888 "Telomere Maintenance, Mus musculus" xref: Reactome:REACT_85317 "Disassociation of Processive Complex and Completed Telomere End, Oryza sativa" xref: Reactome:REACT_85782 "Telomere Maintenance, Arabidopsis thaliana" xref: Reactome:REACT_86038 "Telomere Maintenance, Drosophila melanogaster" xref: Reactome:REACT_86194 "Disassociation of Processive Complex and Completed Telomere End, Arabidopsis thaliana" xref: Reactome:REACT_87184 "Telomere Maintenance, Caenorhabditis elegans" xref: Reactome:REACT_88530 "Packaging Of Telomere Ends, Mus musculus" xref: Reactome:REACT_94176 "Telomere Maintenance, Gallus gallus" xref: Reactome:REACT_94707 "Telomere Maintenance, Oryza sativa" xref: Reactome:REACT_96013 "Telomere Maintenance, Taeniopygia guttata" xref: Reactome:REACT_96166 "Telomere Maintenance, Xenopus tropicalis" is_a: GO:0006259 ! DNA metabolic process is_a: GO:0032200 ! telomere organization is_a: GO:0044710 ! single-organism metabolic process is_a: GO:0060249 ! anatomical structure homeostasis is_a: GO:1902589 ! single-organism organelle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000724 name: double-strand break repair via homologous recombination namespace: biological_process alt_id: GO:0016924 def: "The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855] subset: gosubset_prok synonym: "HDR" EXACT [GOC:vk] synonym: "homologous recombinational repair" EXACT [] synonym: "homology-directed repair" EXACT [GOC:vk] synonym: "HRR" EXACT [] synonym: "Rad51-dependent recombinational repair" EXACT [GOC:mah] synonym: "Rhp51-dependent recombinational repair" EXACT [] xref: Reactome:REACT_103005 "Homologous Recombination Repair, Caenorhabditis elegans" xref: Reactome:REACT_108237 "Homologous Recombination Repair, Saccharomyces cerevisiae" xref: Reactome:REACT_115539 "Recruitment of repair and signaling proteins to double-strand breaks, Gallus gallus" xref: Reactome:REACT_115585 "Homologous recombination repair of replication-dependent double-strand breaks, Gallus gallus" xref: Reactome:REACT_115626 "Homologous DNA pairing and strand exchange, Gallus gallus" xref: Reactome:REACT_115651 "ATM mediated response to DNA double-strand break, Gallus gallus" xref: Reactome:REACT_115715 "ATM mediated phosphorylation of repair proteins, Gallus gallus" xref: Reactome:REACT_115769 "Homologous recombination repair, Gallus gallus" xref: Reactome:REACT_115931 "Processing of DNA double-strand break ends, Gallus gallus" xref: Reactome:REACT_115936 "Homologous recombination repair (HRR) of replication-independent double-strand breaks, Gallus gallus" xref: Reactome:REACT_1874 "Homologous Recombination Repair, Homo sapiens" xref: Reactome:REACT_29815 "Homologous Recombination Repair, Sus scrofa" xref: Reactome:REACT_33853 "Homologous Recombination Repair, Oryza sativa" xref: Reactome:REACT_42307 "Homologous Recombination Repair, Gallus gallus" xref: Reactome:REACT_80576 "Homologous Recombination Repair, Schizosaccharomyces pombe" xref: Reactome:REACT_82771 "Homologous Recombination Repair, Xenopus tropicalis" xref: Reactome:REACT_83941 "Homologous Recombination Repair, Plasmodium falciparum" xref: Reactome:REACT_84594 "Homologous Recombination Repair, Dictyostelium discoideum" xref: Reactome:REACT_84793 "Homologous Recombination Repair, Danio rerio" xref: Reactome:REACT_85965 "Homologous Recombination Repair, Drosophila melanogaster" xref: Reactome:REACT_87979 "Homologous Recombination Repair, Mycobacterium tuberculosis" xref: Reactome:REACT_90944 "Homologous Recombination Repair, Mus musculus" xref: Reactome:REACT_92384 "Homologous Recombination Repair, Canis familiaris" xref: Reactome:REACT_92897 "Homologous Recombination Repair, Arabidopsis thaliana" xref: Reactome:REACT_97339 "Homologous Recombination Repair, Taeniopygia guttata" xref: Reactome:REACT_99066 "Homologous Recombination Repair, Rattus norvegicus" xref: Reactome:REACT_99423 "Homologous Recombination Repair, Bos taurus" is_a: GO:0000725 ! recombinational repair is_a: GO:0006302 ! double-strand break repair property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000725 name: recombinational repair namespace: biological_process def: "A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA." [GOC:elh] subset: gosubset_prok xref: Wikipedia:Recombinational_repair is_a: GO:0006281 ! DNA repair is_a: GO:0006310 ! DNA recombination property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000726 name: non-recombinational repair namespace: biological_process def: "A DNA repair process in which that does not require the exchange of genetic material between the broken DNA molecule and a homologous region of DNA." [GOC:elh] subset: gosubset_prok is_a: GO:0006281 ! DNA repair property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000728 name: gene conversion at mating-type locus, DNA double-strand break formation namespace: biological_process def: "The site-specific endonucleolytic cleavage of DNA at the mating-type locus which initiates the conversion of one mating-type allele to another." [GOC:elh, PMID:7646483] is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis relationship: part_of GO:0007534 ! gene conversion at mating-type locus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000729 name: DNA double-strand break processing namespace: biological_process def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang." [PMID:10357855] xref: Reactome:REACT_172 "Resection of double-strand break ends, Homo sapiens" is_a: GO:0006259 ! DNA metabolic process relationship: has_part GO:0035312 ! 5'-3' exodeoxyribonuclease activity relationship: part_of GO:0006302 ! double-strand break repair property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000732 name: strand displacement namespace: biological_process def: "The rejection of the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules." [PMID:10357855] subset: gosubset_prok synonym: "D-loop dissociation" RELATED [GOC:mah, GOC:vw] synonym: "D-loop processing" RELATED [GOC:mah, GOC:vw] synonym: "displacement loop dissociation" RELATED [GOC:mah, GOC:vw] synonym: "displacement loop processing" RELATED [GOC:mah, GOC:vw] xref: Reactome:REACT_287 "Dissociation of the extended strands, Homo sapiens" is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006310 ! DNA recombination property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000741 name: karyogamy namespace: biological_process alt_id: GO:0007335 def: "The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei." [GOC:elh] synonym: "nuclear fusion" EXACT [] synonym: "nuclear fusion during karyogamy" EXACT [] xref: Wikipedia:Karyogamy is_a: GO:0048284 ! organelle fusion relationship: part_of GO:0006997 ! nucleus organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000742 name: karyogamy involved in conjugation with cellular fusion namespace: biological_process def: "During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after cytogamy." [GOC:elh] synonym: "karyogamy during conjugation with cellular fusion" RELATED [GOC:dph, GOC:tb] is_a: GO:0000741 ! karyogamy intersection_of: GO:0000741 ! karyogamy intersection_of: part_of GO:0000747 ! conjugation with cellular fusion relationship: part_of GO:0000747 ! conjugation with cellular fusion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000743 name: nuclear migration involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0006946 def: "The microtubule-based movement of nuclei towards one another as a prelude to karyogamy in organisms undergoing conjugation with cellular fusion." [GOC:clt, GOC:vw, PMID:16380440] synonym: "nuclear congression" EXACT [GOC:vw] synonym: "nuclear migration during conjugation with cellular fusion" RELATED [GOC:dph, GOC:tb] is_a: GO:0030473 ! nuclear migration along microtubule intersection_of: GO:0007097 ! nuclear migration intersection_of: part_of GO:0000747 ! conjugation with cellular fusion relationship: part_of GO:0000747 ! conjugation with cellular fusion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000746 name: conjugation namespace: biological_process def: "The union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms." [GOC:elh] subset: goslim_aspergillus subset: goslim_candida subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast subset: gosubset_prok xref: Wikipedia:Conjugation is_a: GO:0044764 ! multi-organism cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000747 name: conjugation with cellular fusion namespace: biological_process alt_id: GO:0007322 alt_id: GO:0007333 alt_id: GO:0030461 alt_id: GO:0030477 def: "A conjugation process that results in the union of cellular and genetic information from compatible mating types. An example of this process is found in Saccharomyces cerevisiae." [GOC:elh] subset: goslim_pombe synonym: "cell fusion" RELATED [] synonym: "mating" RELATED [] is_a: GO:0000746 ! conjugation is_a: GO:0019953 ! sexual reproduction property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000749 name: response to pheromone involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0007328 alt_id: GO:0030434 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that contributes to the process of conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt] synonym: "response to pheromone during conjugation with cellular fusion" RELATED [GOC:dph] is_a: GO:0071444 ! cellular response to pheromone intersection_of: GO:0019236 ! response to pheromone intersection_of: part_of GO:0000747 ! conjugation with cellular fusion relationship: part_of GO:0000747 ! conjugation with cellular fusion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000751 name: mitotic cell cycle arrest in response to pheromone namespace: biological_process alt_id: GO:0030571 def: "The cell cycle regulatory process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of a pheromone stimulus. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt, GOC:dph, GOC:mah, GOC:tb] synonym: "cell cycle arrest in response to pheromone" BROAD [] is_a: GO:0071850 ! mitotic cell cycle arrest relationship: part_of GO:0000749 ! response to pheromone involved in conjugation with cellular fusion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000752 name: agglutination involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0007334 def: "During conjugation with cellular fusion, the aggregation or adhesion of compatible mating types via complementary cell-cell interactions. An example of this process is agglutination in Saccharomyces cerevisiae." [GOC:elh] synonym: "agglutination" BROAD [] synonym: "cell-cell adhesion during conjugation with cellular fusion" EXACT [] synonym: "cell-cell adhesion during mating" EXACT [] is_a: GO:0000771 ! agglutination involved in conjugation is_a: GO:0098630 ! aggregation of unicellular organisms intersection_of: GO:0098610 ! adhesion between unicellular organisms intersection_of: part_of GO:0000747 ! conjugation with cellular fusion relationship: part_of GO:0000747 ! conjugation with cellular fusion relationship: part_of GO:0000749 ! response to pheromone involved in conjugation with cellular fusion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000753 name: cell morphogenesis involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0007332 def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation cellular fusion." [GOC:clt] synonym: "shmoo orientation" NARROW [] synonym: "shmooing" NARROW [] is_a: GO:0000767 ! cell morphogenesis involved in conjugation is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0044702 ! single organism reproductive process intersection_of: GO:0000902 ! cell morphogenesis intersection_of: part_of GO:0000747 ! conjugation with cellular fusion relationship: part_of GO:0000747 ! conjugation with cellular fusion relationship: part_of GO:0000749 ! response to pheromone involved in conjugation with cellular fusion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000754 name: adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0007331 alt_id: GO:0030453 def: "In organisms that undergo conjugation with cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses. An example of this is the adaptation to pheromone during conjugation with cellular fusion in Saccharomyces cerevisiae." [GOC:clt] synonym: "adaptation of signalling pathway by response to pheromone involved in conjugation with cellular fusion" EXACT [GOC:mah] synonym: "adaptation to pheromone during conjugation with cellular fusion" RELATED [GOC:dph, GOC:tb] synonym: "desensitization to pheromone during conjugation with cellular fusion" EXACT [] is_a: GO:0023058 ! adaptation of signaling pathway relationship: part_of GO:0000749 ! response to pheromone involved in conjugation with cellular fusion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000755 name: cytogamy namespace: biological_process alt_id: GO:0000218 alt_id: GO:0030462 def: "During conjugation with cellular fusion, the process resulting in creating a single cell from complementary mating types. The localized remodeling and dissolution of external protective structures allow the fusion of the plasma membranes and cytoplasmic mixing. An example of this process is found in Saccharomyces cerevisiae." [GOC:elh] synonym: "zygote formation" RELATED [] is_a: GO:0022413 ! reproductive process in single-celled organism relationship: part_of GO:0000747 ! conjugation with cellular fusion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000767 name: cell morphogenesis involved in conjugation namespace: biological_process def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types." [GOC:elh] is_a: GO:0000902 ! cell morphogenesis intersection_of: GO:0000902 ! cell morphogenesis intersection_of: part_of GO:0000746 ! conjugation relationship: part_of GO:0000746 ! conjugation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000771 name: agglutination involved in conjugation namespace: biological_process def: "The aggregation or adhesion of compatible mating types via complementary cell-cell interactions prior to the formation of irreversible cellular contacts during conjugation." [GOC:elh] is_a: GO:0007157 ! heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules is_a: GO:0098610 ! adhesion between unicellular organisms intersection_of: GO:0098610 ! adhesion between unicellular organisms intersection_of: part_of GO:0000746 ! conjugation relationship: part_of GO:0000746 ! conjugation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000775 name: chromosome, centromeric region namespace: cellular_component alt_id: GO:0097521 def: "The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr] comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. synonym: "centromere" RELATED [] synonym: "centromere complex" EXACT [] synonym: "chromosome, centric region" EXACT [] synonym: "chromosome, pericentric region" RELATED [] is_a: GO:0098687 ! chromosomal region property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000776 name: kinetochore namespace: cellular_component alt_id: GO:0005699 def: "A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh] comment: Note that the kinetochore overlaps the centromeric DNA, but centromeric DNA is not part of the kinetochore. subset: goslim_pir xref: Wikipedia:Kinetochore is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000775 ! chromosome, centromeric region property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000781 name: chromosome, telomeric region namespace: cellular_component def: "The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins." [GOC:elh] comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. synonym: "telomere" RELATED [] is_a: GO:0098687 ! chromosomal region property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000785 name: chromatin namespace: cellular_component alt_id: GO:0005717 def: "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. synonym: "chromosome scaffold" RELATED [] xref: NIF_Subcellular:sao1615953555 is_a: GO:0032991 ! macromolecular complex is_a: GO:0044427 ! chromosomal part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000790 name: nuclear chromatin namespace: cellular_component def: "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus." [GOC:elh, PMID:20404130] is_a: GO:0000785 ! chromatin is_a: GO:0044454 ! nuclear chromosome part intersection_of: GO:0000785 ! chromatin intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0005634 ! nucleus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000791 name: euchromatin namespace: cellular_component def: "A dispersed and relatively uncompacted form of chromatin." [GOC:elh] xref: NIF_Subcellular:sao445485807 xref: Wikipedia:Euchromatin is_a: GO:0000785 ! chromatin property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000792 name: heterochromatin namespace: cellular_component def: "A compact and highly condensed form of chromatin." [GOC:elh] xref: NIF_Subcellular:sao581845896 xref: Wikipedia:Heterochromatin is_a: GO:0000785 ! chromatin property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000793 name: condensed chromosome namespace: cellular_component def: "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh] comment: Note that this term can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes an 'open mitosis' in which the nuclear envelope breaks down during mitosis. synonym: "cytoplasmic mitotic chromosome" RELATED [] synonym: "metaphase chromosome" RELATED [] synonym: "mitotic chromosome" RELATED [] is_a: GO:0005694 ! chromosome property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000794 name: condensed nuclear chromosome namespace: cellular_component def: "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure that remains in the nucleus." [GOC:elh] comment: Note that this term and its children can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes a 'closed mitosis' in which the nuclear envelope does not break down during mitosis and for gene products that localize to a meiotic chromosome. synonym: "meiotic chromosome" RELATED [] synonym: "nuclear mitotic chromosome" RELATED [] is_a: GO:0000228 ! nuclear chromosome is_a: GO:0000793 ! condensed chromosome intersection_of: GO:0000793 ! condensed chromosome intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0005634 ! nucleus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000808 name: origin recognition complex namespace: cellular_component def: "A multisubunit complex that is located at the replication origins of a chromosome." [GOC:elh] subset: goslim_pir subset: gosubset_prok synonym: "ORC" EXACT [] synonym: "origin of replication recognition complex" EXACT [] xref: Wikipedia:Origin_recognition_complex is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000811 name: GINS complex namespace: cellular_component def: "A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks." [GOC:rb, GOC:rn, PMID:12730134, PMID:16990792, PMID:17467990] synonym: "Go, Ichi, Ni and San complex" EXACT [] is_a: GO:0031261 ! DNA replication preinitiation complex is_a: GO:0044454 ! nuclear chromosome part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000819 name: sister chromatid segregation namespace: biological_process def: "The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets." [GOC:ai, GOC:elh] is_a: GO:0051276 ! chromosome organization is_a: GO:0098813 ! nuclear chromosome segregation is_a: GO:1902589 ! single-organism organelle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000902 name: cell morphogenesis namespace: biological_process alt_id: GO:0007148 alt_id: GO:0045790 alt_id: GO:0045791 def: "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast subset: gosubset_prok synonym: "cellular morphogenesis" EXACT [] is_a: GO:0032989 ! cellular component morphogenesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000906 name: 6,7-dimethyl-8-ribityllumazine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxy-2-butanone-4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate." [EC:5.4.-.-, PMID:7559556] synonym: "lumazine synthase activity" BROAD [MetaCyc:LUMAZINESYN-CPLX] xref: EC:5.4.-.- is_a: GO:0016867 ! intramolecular transferase activity, transferring acyl groups property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000910 name: cytokinesis namespace: biological_process alt_id: GO:0007104 alt_id: GO:0016288 alt_id: GO:0033205 def: "The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells." [GOC:mtg_cell_cycle] comment: Note that when annotating eukaryotic species, mitotic or meiotic cytokinesis should always be specified for manual annotation and for prokaryotic species use 'FtsZ-dependent cytokinesis ; GO:0043093' or Cdv-dependent cytokinesis ; GO:0061639. Also, note that cytokinesis does not necessarily result in physical separation and detachment of the two daughter cells from each other. subset: gocheck_do_not_manually_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_yeast subset: gosubset_prok synonym: "cell cycle cytokinesis" EXACT [] synonym: "cytokinesis involved in cell cycle" EXACT [GOC:dph, GOC:tb] xref: Reactome:REACT_101918 "Mitotic Telophase /Cytokinesis, Mus musculus" xref: Reactome:REACT_108805 "Mitotic Telophase /Cytokinesis, Dictyostelium discoideum" xref: Reactome:REACT_1932 "Mitotic Telophase /Cytokinesis, Homo sapiens" xref: Reactome:REACT_30667 "Mitotic Telophase /Cytokinesis, Schizosaccharomyces pombe" xref: Reactome:REACT_32636 "Mitotic Telophase /Cytokinesis, Bos taurus" xref: Reactome:REACT_78494 "Mitotic Telophase /Cytokinesis, Danio rerio" xref: Reactome:REACT_84722 "Mitotic Telophase /Cytokinesis, Gallus gallus" xref: Reactome:REACT_87726 "Mitotic Telophase /Cytokinesis, Xenopus tropicalis" xref: Reactome:REACT_92849 "Mitotic Telophase /Cytokinesis, Taeniopygia guttata" xref: Reactome:REACT_93374 "Mitotic Telophase /Cytokinesis, Canis familiaris" xref: Reactome:REACT_94382 "Mitotic Telophase /Cytokinesis, Drosophila melanogaster" xref: Reactome:REACT_98952 "Mitotic Telophase /Cytokinesis, Rattus norvegicus" xref: Reactome:REACT_99118 "Mitotic Telophase /Cytokinesis, Caenorhabditis elegans" xref: Wikipedia:Cytokinesis is_a: GO:0022402 ! cell cycle process relationship: has_part GO:0090148 ! membrane fission relationship: part_of GO:0051301 ! cell division property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000912 name: assembly of actomyosin apparatus involved in cytokinesis namespace: biological_process def: "The assembly and arrangement of an apparatus composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:mtg_cell_cycle] synonym: "actomyosin apparatus assembly involved in cytokinesis" EXACT [GOC:mah] synonym: "cytokinesis, formation of actomyosin apparatus" EXACT [GOC:dph, GOC:tb] synonym: "formation of actomyosin apparatus involved in cytokinesis" RELATED [GOC:dph] is_a: GO:0022607 ! cellular component assembly is_a: GO:0032506 ! cytokinetic process relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000915 name: actomyosin contractile ring assembly namespace: biological_process alt_id: GO:0045573 def: "The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:dph, GOC:tb] synonym: "constriction ring assembly" NARROW [] synonym: "contractile ring assembly" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "cytokinesis, actomyosin contractile ring assembly" EXACT [] synonym: "cytokinesis, actomyosin contractile ring formation" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "cytokinesis, actomyosin ring biosynthesis" RELATED [] synonym: "cytokinesis, actomyosin ring formation" RELATED [] synonym: "cytokinesis, contractile ring assembly" RELATED [GOC:mah] is_a: GO:0000912 ! assembly of actomyosin apparatus involved in cytokinesis is_a: GO:0044837 ! actomyosin contractile ring organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000916 name: actomyosin contractile ring contraction namespace: biological_process def: "The process of an actomyosin ring getting smaller in diameter, in the context of cytokinesis that takes place as part of a cell cycle." [GOC:clt, GOC:dph, GOC:mah, GOC:tb] synonym: "contractile ring constriction" BROAD [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "contractile ring contraction involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw] synonym: "cytokinesis, actomyosin ring contraction" EXACT [] synonym: "cytokinesis, contractile ring contraction" BROAD [GOC:dph, GOC:tb] is_a: GO:0036213 ! contractile ring contraction relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000917 name: barrier septum assembly namespace: biological_process alt_id: GO:0071937 alt_id: GO:1902411 def: "The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a barrier septum are not able to exchange intracellular material." [GOC:mtg_cell_cycle] synonym: "barrier septum assembly involved in cell cycle cytokinesis" EXACT [] synonym: "barrier septum assembly involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "barrier septum formation" EXACT [GOC:mah] synonym: "barrier septum formation involved in cell cycle cytokinesis" EXACT [] synonym: "barrier septum formation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "barrier septum formation involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "formation of barrier septum" EXACT [] synonym: "formation of barrier septum involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "mitotic barrier septum assembly" EXACT [] synonym: "septation" BROAD [] synonym: "septin assembly and septum biosynthesis" RELATED [] synonym: "septin assembly and septum biosynthesis involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "septin assembly and septum formation" RELATED [] synonym: "septin assembly and septum formation involved in mitotic cell cycle" RELATED [GOC:TermGenie] is_a: GO:0090529 ! cell septum assembly is_a: GO:1902410 ! mitotic cytokinetic process relationship: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000281 ! mitotic cytokinesis relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000918 name: barrier septum site selection namespace: biological_process def: "The process of marking the site where a barrier septum will form." [GOC:clt] synonym: "selection of site for barrier cell septum biosynthesis" EXACT [] synonym: "selection of site for barrier cell septum formation" EXACT [] synonym: "selection of site for barrier septum formation" EXACT [GOC:curators] synonym: "septin assembly and septum biosynthesis" BROAD [] synonym: "septin assembly and septum formation" BROAD [] synonym: "septum positioning" EXACT [] is_a: GO:1902410 ! mitotic cytokinetic process relationship: part_of GO:0000917 ! barrier septum assembly property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000920 name: cell separation after cytokinesis namespace: biological_process alt_id: GO:1902409 alt_id: GO:2000695 def: "The process of physically separating progeny cells after cytokinesis; this may involve enzymatic digestion of septum or cell wall components." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "cell separation following cytokinesis" EXACT [GOC:dph, GOC:tb] synonym: "cytokinetic cell separation" RELATED [] synonym: "mitotic cytokinetic cell separation" EXACT [] synonym: "rotokinesis" NARROW [] is_a: GO:0009987 ! cellular process relationship: part_of GO:0051301 ! cell division property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000922 name: spindle pole namespace: cellular_component alt_id: GO:0030615 def: "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt] is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0005819 ! spindle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000923 name: equatorial microtubule organizing center namespace: cellular_component def: "A microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis." [PMID:11792817] synonym: "EMTOC" EXACT [] synonym: "equatorial microtubule organising centre" EXACT [] is_a: GO:0005815 ! microtubule organizing center is_a: GO:0032155 ! cell division site part intersection_of: GO:0005815 ! microtubule organizing center intersection_of: part_of GO:0032153 ! cell division site relationship: part_of GO:0032153 ! cell division site property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000932 name: cytoplasmic mRNA processing body namespace: cellular_component def: "A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci." [GOC:clt, PMID:12730603] synonym: "cytoplasmic foci" RELATED [] synonym: "P body" EXACT [] synonym: "P-body" EXACT [] xref: Wikipedia:P_body is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000935 name: barrier septum namespace: cellular_component def: "A septum which spans a cell and does not allow exchange of organelles or cytoplasm between compartments." [GOC:clt] synonym: "complete septum" EXACT [] is_a: GO:0030428 ! cell septum property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000936 name: primary cell septum namespace: cellular_component def: "A cell septum that forms following nuclear division." [GOC:clt, ISBN:0471940526] synonym: "primary septum" BROAD [] is_a: GO:0030428 ! cell septum property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000956 name: nuclear-transcribed mRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells." [GOC:krc] synonym: "nuclear mRNA breakdown" EXACT [] synonym: "nuclear mRNA catabolism" EXACT [] synonym: "nuclear mRNA degradation" EXACT [] is_a: GO:0006402 ! mRNA catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000959 name: mitochondrial RNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah] is_a: GO:0016070 ! RNA metabolic process intersection_of: GO:0016070 ! RNA metabolic process intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000963 name: mitochondrial RNA processing namespace: biological_process def: "The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion." [GOC:krc, GOC:mah] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006396 ! RNA processing is_a: GO:0007005 ! mitochondrion organization is_a: GO:0044710 ! single-organism metabolic process is_a: GO:1902589 ! single-organism organelle organization intersection_of: GO:0006396 ! RNA processing intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000965 name: mitochondrial RNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion." [GOC:krc, GOC:mah] synonym: "mitochondrial RNA 3' end processing" RELATED [] is_a: GO:0000963 ! mitochondrial RNA processing is_a: GO:0031123 ! RNA 3'-end processing intersection_of: GO:0031123 ! RNA 3'-end processing intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000966 name: RNA 5'-end processing namespace: biological_process def: "Any process involved in forming the mature 5' end of an RNA molecule." [GOC:krc] synonym: "RNA 5' end processing" EXACT [] is_a: GO:0006396 ! RNA processing property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000967 name: rRNA 5'-end processing namespace: biological_process def: "Any process involved in forming the mature 5' end of an rRNA molecule." [GOC:krc] synonym: "rRNA 5' end processing" EXACT [] is_a: GO:0006364 ! rRNA processing is_a: GO:0034471 ! ncRNA 5'-end processing property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0000975 name: regulatory region DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA region that regulates a DNA-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH] is_a: GO:0001067 ! regulatory region nucleic acid binding is_a: GO:0003677 ! DNA binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: kchris creation_date: 2010-08-10T10:56:24Z [Term] id: GO:0000976 name: transcription regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". is_a: GO:0043565 ! sequence-specific DNA binding is_a: GO:0044212 ! transcription regulatory region DNA binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: kchris creation_date: 2010-08-10T11:00:02Z [Term] id: GO:0000977 name: RNA polymerase II regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH] comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding is_a: GO:0001012 ! RNA polymerase II regulatory region DNA binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: kchris creation_date: 2010-08-10T11:05:36Z [Term] id: GO:0000978 name: RNA polymerase II core promoter proximal region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II." [GOC:txnOH] comment: Note that the phrase "upstream activating sequence", or UAS is often used in S. cerevisiae literature to refer to regulatory sequences that occur in the region upstream and proximal to the core promoter. In contrast, in bacteria such as E. coli, the phrase "upstream activating sequence", or UAS is a synonym for "enhancer". synonym: "RNA polymerase II upstream activating sequence (UAS) sequence-specific DNA binding" RELATED [] is_a: GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding is_a: GO:0000987 ! core promoter proximal region sequence-specific DNA binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: kchris creation_date: 2010-08-10T02:17:19Z [Term] id: GO:0000987 name: core promoter proximal region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding is_a: GO:0001159 ! core promoter proximal region DNA binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: kchris creation_date: 2010-08-10T03:40:16Z [Term] id: GO:0001012 name: RNA polymerase II regulatory region DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase II. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH, GOC:vw] is_a: GO:0044212 ! transcription regulatory region DNA binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: kchris creation_date: 2010-08-19T09:43:58Z [Term] id: GO:0001067 name: regulatory region nucleic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH] is_a: GO:0003676 ! nucleic acid binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: kchris creation_date: 2010-10-21T04:08:56Z [Term] id: GO:0001101 name: response to acid chemical namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:go_curators, GOC:rn, http://en.wikipedia.org/wiki/Acid] comment: This term should be used to describe a response to a specific acid as a chemical. E.g., if an organism were responding to glutamate, then the response would be glutamate-specific; the organism is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0010447 'response to acidic pH' instead. subset: gocheck_do_not_manually_annotate synonym: "response to acid" BROAD [] synonym: "response to acid anion" RELATED [] synonym: "response to oxoanion" RELATED [] is_a: GO:0042221 ! response to chemical property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0001159 name: core promoter proximal region DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] is_a: GO:0044212 ! transcription regulatory region DNA binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: kchris creation_date: 2011-01-28T03:37:52Z [Term] id: GO:0001207 name: histone displacement namespace: biological_process def: "The removal of histones, including histone dimers, from nucleosomes within chromatin." [GOC:krc, PMID:15525516, PMID:17496903, PMID:21807128] is_a: GO:0034728 ! nucleosome organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: karen creation_date: 2012-03-27T10:56:56Z [Term] id: GO:0001510 name: RNA methylation namespace: biological_process def: "Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor." [GOC:hjd] subset: gosubset_prok is_a: GO:0009451 ! RNA modification is_a: GO:0043414 ! macromolecule methylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0001558 name: regulation of cell growth namespace: biological_process def: "Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators] subset: gosubset_prok xref: Reactome:REACT_6201 "DTOR is positively regulated by DRheb-GTP, Drosophila melanogaster" is_a: GO:0040008 ! regulation of growth is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016049 ! cell growth relationship: regulates GO:0016049 ! cell growth property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0001578 name: microtubule bundle formation namespace: biological_process def: "A process that results in a parallel arrangement of microtubules." [GOC:dph] synonym: "microtubule bundling" EXACT [] is_a: GO:0000226 ! microtubule cytoskeleton organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0001666 name: response to hypoxia namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] comment: Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%. synonym: "response to hypoxic stress" EXACT [] synonym: "response to lowered oxygen tension" EXACT [] is_a: GO:0006950 ! response to stress is_a: GO:0036293 ! response to decreased oxygen levels property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0001676 name: long-chain fatty acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:ajp] subset: gosubset_prok synonym: "long-chain fatty acid metabolism" EXACT [] is_a: GO:0006631 ! fatty acid metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0001678 name: cellular glucose homeostasis namespace: biological_process def: "A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment." [GOC:dph, GOC:go_curators, GOC:tb] subset: gosubset_prok synonym: "cell glucose homeostasis" EXACT [GOC:dph, GOC:tb] is_a: GO:0042593 ! glucose homeostasis is_a: GO:0055082 ! cellular chemical homeostasis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0001882 name: nucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose." [GOC:hjd] subset: goslim_pir subset: gosubset_prok is_a: GO:0036094 ! small molecule binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:0097367 ! carbohydrate derivative binding is_a: GO:1901363 ! heterocyclic compound binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0001883 name: purine nucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose." [GOC:hjd] is_a: GO:0001882 ! nucleoside binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0001932 name: regulation of protein phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd] subset: gosubset_prok synonym: "regulation of protein amino acid phosphorylation" EXACT [GOC:bf] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0042325 ! regulation of phosphorylation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006468 ! protein phosphorylation relationship: regulates GO:0006468 ! protein phosphorylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0002097 name: tRNA wobble base modification namespace: biological_process def: "The process in which the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X] is_a: GO:0006400 ! tRNA modification property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0002098 name: tRNA wobble uridine modification namespace: biological_process def: "The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X] is_a: GO:0002097 ! tRNA wobble base modification property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0002180 name: 5-lipoxygenase complex namespace: cellular_component def: "An nuclear membrane protein complex having arachidonate 5-lipoxygenase activity." [PMID:19075240] is_a: GO:0044453 ! nuclear membrane part is_a: GO:0098796 ! membrane protein complex is_a: GO:1990204 ! oxidoreductase complex property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: hjd creation_date: 2011-06-09T01:05:53Z [Term] id: GO:0002181 name: cytoplasmic translation namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd] comment: Note that this term applies to translation performed by cytoplasmic ribosomes, which is distinct from translation performed by organellar ribosomes. For mitochondrial translation, consider GO:0032543 'mitochondrial translation' or its child terms. subset: goslim_pombe subset: goslim_yeast is_a: GO:0006412 ! translation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: hjd creation_date: 2011-06-09T03:11:53Z [Term] id: GO:0002183 name: cytoplasmic translational initiation namespace: biological_process def: "The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:hjd] is_a: GO:0006413 ! translational initiation relationship: part_of GO:0002181 ! cytoplasmic translation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: hjd creation_date: 2011-06-09T03:15:48Z [Term] id: GO:0002926 name: tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis. namespace: biological_process def: "The process whereby a wobble base uridine residue in a tRNA is modified to 5-methoxycarbonylmethyl-2-thiouridine." [GOC:hjd, UniPathway:UPA00988] synonym: "mcm5s2U34 biosynthesis" EXACT [] is_a: GO:0002098 ! tRNA wobble uridine modification property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: hjd creation_date: 2012-01-17T02:50:54Z [Term] id: GO:0002940 name: tRNA N2-guanine methylation namespace: biological_process def: "The process whereby a guanine in a tRNA is methylated at the N2 position of guanine." [ISBN:155581073X, ISBN:1555811337] synonym: "tRNA m2-guanine biosynthesis" RELATED [] is_a: GO:0030488 ! tRNA methylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: hjd creation_date: 2012-11-09T16:23:41Z [Term] id: GO:0003006 name: developmental process involved in reproduction namespace: biological_process def: "A developmental process in which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring." [GOC:dph, GOC:isa_complete] synonym: "puberty" NARROW [GOC:dph] synonym: "reproductive developmental process" RELATED [GOC:dph, GOC:tb] is_a: GO:0022414 ! reproductive process is_a: GO:0032502 ! developmental process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0003674 name: molecular_function namespace: molecular_function alt_id: GO:0005554 def: "Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions." [GOC:go_curators] comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. Note that when this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "molecular function" EXACT [] property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0003676 name: nucleic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: gosubset_prok is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0003677 name: DNA binding namespace: molecular_function def: "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "microtubule/chromatin interaction" RELATED [] synonym: "plasmid binding" NARROW [] is_a: GO:0003676 ! nucleic acid binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0003678 name: DNA helicase activity namespace: molecular_function alt_id: GO:0003679 def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah] subset: gosubset_prok xref: Reactome:REACT_116013 "BRIP1 (FANCJ) helicase functions in direct unwinding of DNA, Gallus gallus" is_a: GO:0004386 ! helicase activity relationship: part_of GO:0032508 ! DNA duplex unwinding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0003682 name: chromatin binding namespace: molecular_function def: "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] subset: goslim_chembl subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "lamin/chromatin binding" BROAD [] synonym: "microtubule/chromatin interaction" RELATED [] synonym: "nuclear membrane vesicle binding to chromatin" NARROW [] is_a: GO:0044877 ! macromolecular complex binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0003688 name: DNA replication origin binding namespace: molecular_function def: "Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally." [GOC:curators] subset: gosubset_prok synonym: "ARS binding" NARROW [] is_a: GO:0043565 ! sequence-specific DNA binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0003696 name: satellite DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA." [GOC:jl, SO:0000005] is_a: GO:0043565 ! sequence-specific DNA binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0003697 name: single-stranded DNA binding namespace: molecular_function alt_id: GO:0003698 alt_id: GO:0003699 def: "Interacting selectively and non-covalently with single-stranded DNA." [GOC:elh] comment: Note that this term is restricted to those cases where the binding is to a single-stranded DNA molecule, not to one of the stands of double-stranded DNA. subset: gosubset_prok synonym: "ssDNA binding" EXACT [GOC:mah] is_a: GO:0043566 ! structure-specific DNA binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0003723 name: RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: Reactome:REACT_101703 "Exportin-5 recognizes 3' overhang of pre-miRNA, Xenopus tropicalis" xref: Reactome:REACT_103323 "Exportin-5 recognizes 3' overhang of pre-miRNA, Dictyostelium discoideum" xref: Reactome:REACT_106430 "Exportin-5 recognizes 3' overhang of pre-miRNA, Mus musculus" xref: Reactome:REACT_107757 "Exportin-5 recognizes 3' overhang of pre-miRNA, Drosophila melanogaster" xref: Reactome:REACT_108232 "Exportin-5 recognizes 3' overhang of pre-miRNA, Oryza sativa" xref: Reactome:REACT_108368 "Exportin-5 recognizes 3' overhang of pre-miRNA, Saccharomyces cerevisiae" xref: Reactome:REACT_109723 "Exportin-5 recognizes 3' overhang of pre-miRNA, Arabidopsis thaliana" xref: Reactome:REACT_12458 "Exportin-5 recognizes 3' overhang of pre-miRNA, Homo sapiens" xref: Reactome:REACT_29965 "Exportin-5 recognizes 3' overhang of pre-miRNA, Canis familiaris" xref: Reactome:REACT_77167 "Exportin-5 recognizes 3' overhang of pre-miRNA, Gallus gallus" xref: Reactome:REACT_78197 "Exportin-5 recognizes 3' overhang of pre-miRNA, Sus scrofa" xref: Reactome:REACT_87164 "Exportin-5 recognizes 3' overhang of pre-miRNA, Schizosaccharomyces pombe" xref: Reactome:REACT_89329 "Exportin-5 recognizes 3' overhang of pre-miRNA, Rattus norvegicus" xref: Reactome:REACT_90531 "Exportin-5 recognizes 3' overhang of pre-miRNA, Danio rerio" xref: Reactome:REACT_98683 "Exportin-5 recognizes 3' overhang of pre-miRNA, Taeniopygia guttata" is_a: GO:0003676 ! nucleic acid binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0003727 name: single-stranded RNA binding namespace: molecular_function alt_id: GO:0003728 def: "Interacting selectively and non-covalently with single-stranded RNA." [GOC:jl] synonym: "ssRNA binding" EXACT [GOC:mah] is_a: GO:0003723 ! RNA binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0003779 name: actin binding namespace: molecular_function def: "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] synonym: "membrane associated actin binding" NARROW [] is_a: GO:0008092 ! cytoskeletal protein binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0003824 name: catalytic activity namespace: molecular_function def: "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732] subset: goslim_chembl subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "enzyme activity" EXACT [GOC:dph, GOC:tb] xref: Wikipedia:Enzyme is_a: GO:0003674 ! molecular_function relationship: part_of GO:0008152 ! metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0003840 name: gamma-glutamyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid." [EC:2.3.2.2] subset: gosubset_prok synonym: "(5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase activity" EXACT [EC:2.3.2.2] synonym: "alpha-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] synonym: "gamma-glutamyl peptidyltransferase activity" EXACT [EC:2.3.2.2] synonym: "gamma-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] synonym: "gamma-GPT" RELATED [EC:2.3.2.2] synonym: "gamma-GT" RELATED [EC:2.3.2.2] synonym: "gamma-GTP" RELATED [EC:2.3.2.2] synonym: "glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] synonym: "L-gamma-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] synonym: "L-gamma-glutamyltransferase activity" EXACT [EC:2.3.2.2] synonym: "L-glutamyltransferase activity" EXACT [EC:2.3.2.2] xref: EC:2.3.2.2 xref: KEGG:R04159 xref: MetaCyc:GAMMA-GLUTAMYLTRANSFERASE-RXN xref: Reactome:REACT_105103 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Taeniopygia guttata" xref: Reactome:REACT_107509 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Xenopus tropicalis" xref: Reactome:REACT_108503 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Escherichia coli" xref: Reactome:REACT_109920 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Oryza sativa" xref: Reactome:REACT_114722 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Caenorhabditis elegans" xref: Reactome:REACT_15356 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Homo sapiens" xref: Reactome:REACT_28900 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Saccharomyces cerevisiae" xref: Reactome:REACT_29202 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Bos taurus" xref: Reactome:REACT_75920 "Glutathione is hydrolyzed, Homo sapiens" xref: Reactome:REACT_79594 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Danio rerio" xref: Reactome:REACT_80649 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Sus scrofa" xref: Reactome:REACT_82062 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Arabidopsis thaliana" xref: Reactome:REACT_85164 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Schizosaccharomyces pombe" xref: Reactome:REACT_92059 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Canis familiaris" xref: Reactome:REACT_97168 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Mus musculus" xref: Reactome:REACT_99498 "Cleavage of the gamma-glutamyl bond of LTC4 forms LTD4, Gallus gallus" is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0003843 name: 1,3-beta-D-glucan synthase activity namespace: molecular_function alt_id: GO:0009981 def: "Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + [(1->3)-beta-D-glucosyl](n+1)." [EC:2.4.1.34] synonym: "(1,3)-beta-glucan (callose) synthase activity" EXACT [EC:2.4.1.34] synonym: "1,3-beta-D-glucan synthetase activity" EXACT [EC:2.4.1.34] synonym: "1,3-beta-D-glucan-UDP glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "1,3-beta-glucan synthase activity" EXACT [EC:2.4.1.34] synonym: "1,3-beta-glucan-uridine diphosphoglucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "beta-1,3-glucan synthase activity" EXACT [] synonym: "beta-1,3-glucan synthetase activity" EXACT [EC:2.4.1.34] synonym: "callose synthase activity" EXACT [] synonym: "callose synthetase activity" EXACT [EC:2.4.1.34] synonym: "GS-II" RELATED [EC:2.4.1.34] synonym: "paramylon synthetase" RELATED [EC:2.4.1.34] synonym: "UDP-glucose-1,3-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDP-glucose-1,3-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDP-glucose-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDP-glucose:(1,3)beta-glucan synthase activity" EXACT [EC:2.4.1.34] synonym: "UDP-glucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDPglucose-1,3-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDPglucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] xref: EC:2.4.1.34 xref: MetaCyc:13-BETA-GLUCAN-SYNTHASE-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0003882 name: CDP-diacylglycerol-serine O-phosphatidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine." [EC:2.7.8.8] subset: gosubset_prok synonym: "CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "phosphatidylserine synthase activity" EXACT [EC:2.7.8.8] synonym: "phosphatidylserine synthetase activity" EXACT [EC:2.7.8.8] synonym: "PS synthase activity" EXACT [EC:2.7.8.8] synonym: "serine exchange enzyme" BROAD [] xref: EC:2.7.8.8 xref: MetaCyc:PHOSPHASERSYN-RXN xref: RHEA:16916 is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0003887 name: DNA-directed DNA polymerase activity namespace: molecular_function alt_id: GO:0003888 alt_id: GO:0003889 alt_id: GO:0003890 alt_id: GO:0003891 alt_id: GO:0003893 alt_id: GO:0003894 alt_id: GO:0003895 alt_id: GO:0008723 alt_id: GO:0015999 alt_id: GO:0016000 alt_id: GO:0016448 alt_id: GO:0016449 alt_id: GO:0016450 alt_id: GO:0016451 alt_id: GO:0016452 alt_id: GO:0019984 def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684] subset: gosubset_prok synonym: "alpha DNA polymerase activity" NARROW [] synonym: "beta DNA polymerase activity" NARROW [] synonym: "delta DNA polymerase activity" NARROW [] synonym: "deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleic acid duplicase activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleic duplicase activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleic polymerase I" NARROW [EC:2.7.7.7] synonym: "DNA duplicase activity" EXACT [EC:2.7.7.7] synonym: "DNA nucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.7] synonym: "DNA polymerase alpha" NARROW [EC:2.7.7.7] synonym: "DNA polymerase beta" NARROW [EC:2.7.7.7] synonym: "DNA polymerase gamma" NARROW [EC:2.7.7.7] synonym: "DNA polymerase I" NARROW [EC:2.7.7.7] synonym: "DNA polymerase II" NARROW [EC:2.7.7.7] synonym: "DNA polymerase III" NARROW [EC:2.7.7.7] synonym: "DNA polymerase V activity" NARROW [] synonym: "DNA replicase activity" EXACT [EC:2.7.7.7] synonym: "DNA-dependent DNA polymerase activity" EXACT [EC:2.7.7.7] synonym: "duplicase" BROAD [EC:2.7.7.7] synonym: "epsilon DNA polymerase activity" NARROW [] synonym: "eta DNA polymerase activity" NARROW [] synonym: "gamma DNA-directed DNA polymerase activity" NARROW [] synonym: "iota DNA polymerase activity" NARROW [] synonym: "kappa DNA polymerase activity" NARROW [] synonym: "Klenow fragment" NARROW [EC:2.7.7.7] synonym: "lambda DNA polymerase activity" NARROW [] synonym: "mu DNA polymerase activity" NARROW [] synonym: "nu DNA polymerase activity" NARROW [] synonym: "sequenase" RELATED [EC:2.7.7.7] synonym: "sigma DNA polymerase activity" NARROW [] synonym: "Taq DNA polymerase" NARROW [EC:2.7.7.7] synonym: "Taq Pol I" NARROW [EC:2.7.7.7] synonym: "Tca DNA polymerase" NARROW [EC:2.7.7.7] synonym: "theta DNA polymerase activity" NARROW [] synonym: "zeta DNA polymerase activity" NARROW [] xref: EC:2.7.7.7 xref: MetaCyc:DNA-DIRECTED-DNA-POLYMERASE-RXN xref: Reactome:REACT_101168 "Misinsertion of bases opposite to the lesion by HREV1, Drosophila melanogaster" xref: Reactome:REACT_101456 "Elongation by HREV1 protein, Arabidopsis thaliana" xref: Reactome:REACT_101578 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Schizosaccharomyces pombe" xref: Reactome:REACT_102164 "DNA strand displacement synthesis, Arabidopsis thaliana" xref: Reactome:REACT_1024 "Formation of Okazaki fragments, Homo sapiens" xref: Reactome:REACT_102850 "Elongation by Pol eta, Sus scrofa" xref: Reactome:REACT_102905 "Resynthesis of excised residue, Mus musculus" xref: Reactome:REACT_103072 "POL Beta mediated incorporation of the first replacement nucleotide, Taeniopygia guttata" xref: Reactome:REACT_103285 "Elongation by Pol zeta complex, Sus scrofa" xref: Reactome:REACT_103439 "Misinsertion of bases opposite to the lesion by HREV1, Taeniopygia guttata" xref: Reactome:REACT_103520 "Elongation by Pol zeta complex, Mus musculus" xref: Reactome:REACT_103531 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Arabidopsis thaliana" xref: Reactome:REACT_104153 "Formation of Okazaki fragments, Arabidopsis thaliana" xref: Reactome:REACT_104851 "Elongation by HREV1 protein, Drosophila melanogaster" xref: Reactome:REACT_104914 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Rattus norvegicus" xref: Reactome:REACT_104973 "Elongation by Pol eta, Arabidopsis thaliana" xref: Reactome:REACT_105070 "Insertion of correct bases opposite to the lesion by Pol eta, Saccharomyces cerevisiae" xref: Reactome:REACT_105462 "Formation of C-strand Okazaki fragments, Sus scrofa" xref: Reactome:REACT_105659 "Repair synthesis of patch ~27-30 bases long by DNA Pol Delta, Danio rerio" xref: Reactome:REACT_105733 "Elongation by HREV1 protein, Canis familiaris" xref: Reactome:REACT_105794 "Insertion of correct bases opposite to the lesion by Pol eta, Arabidopsis thaliana" xref: Reactome:REACT_105961 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Bos taurus" xref: Reactome:REACT_106002 "Resynthesis of excised residue, Rattus norvegicus" xref: Reactome:REACT_106057 "Insertion of correct bases opposite to the lesion by Pol eta, Drosophila melanogaster" xref: Reactome:REACT_106334 "Repair synthesis for gap-filling by DNA pol delta in TC-NER, Canis familiaris" xref: Reactome:REACT_106776 "Elongation by HREV1 protein, Caenorhabditis elegans" xref: Reactome:REACT_106994 "Formation of C-strand Okazaki fragments, Schizosaccharomyces pombe" xref: Reactome:REACT_107125 "Elongation by HREV1 protein, Rattus norvegicus" xref: Reactome:REACT_107358 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Danio rerio" xref: Reactome:REACT_107480 "Elongation by HREV1 protein, Schizosaccharomyces pombe" xref: Reactome:REACT_107781 "Misinsertion of bases opposite to the lesion by HREV1, Rattus norvegicus" xref: Reactome:REACT_107879 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Canis familiaris" xref: Reactome:REACT_107930 "Formation of Okazaki fragments, Mus musculus" xref: Reactome:REACT_108241 "Elongation by HREV1 protein, Xenopus tropicalis" xref: Reactome:REACT_108640 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Drosophila melanogaster" xref: Reactome:REACT_108802 "Elongation by Pol eta, Rattus norvegicus" xref: Reactome:REACT_109069 "Formation of Okazaki fragments, Oryza sativa" xref: Reactome:REACT_109329 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Bos taurus" xref: Reactome:REACT_109542 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Xenopus tropicalis" xref: Reactome:REACT_109593 "Formation of C-strand Okazaki fragments, Mus musculus" xref: Reactome:REACT_109749 "Repair synthesis of patch ~27-30 bases long by DNA Pol Delta, Rattus norvegicus" xref: Reactome:REACT_109858 "Insertion of correct bases opposite to the lesion by Pol eta, Bos taurus" xref: Reactome:REACT_109873 "Repair synthesis for gap-filling by DNA pol delta in TC-NER, Xenopus tropicalis" xref: Reactome:REACT_109947 "Misinsertion of bases opposite to the lesion by HREV1, Xenopus tropicalis" xref: Reactome:REACT_110252 "Formation of C-strand Okazaki fragments, Canis familiaris" xref: Reactome:REACT_112231 "Elongation by Pol zeta complex, Xenopus tropicalis" xref: Reactome:REACT_112289 "Elongation by Pol zeta complex, Taeniopygia guttata" xref: Reactome:REACT_112468 "Elongation by Pol zeta complex, Dictyostelium discoideum" xref: Reactome:REACT_1196 "Repair synthesis for gap-filling by DNA pol delta in TC-NER, Homo sapiens" xref: Reactome:REACT_1324 "Elongation by Pol zeta complex, Homo sapiens" xref: Reactome:REACT_1479 "Elongation by Pol eta, Homo sapiens" xref: Reactome:REACT_2016 "Insertion of correct bases opposite to the lesion by Pol eta, Homo sapiens" xref: Reactome:REACT_2214 "Misinsertion of bases opposite to the lesion by HREV1, Homo sapiens" xref: Reactome:REACT_2224 "POL Beta mediated incorporation of the first replacement nucleotide, Homo sapiens" xref: Reactome:REACT_28103 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Schizosaccharomyces pombe" xref: Reactome:REACT_28619 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Rattus norvegicus" xref: Reactome:REACT_28865 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Dictyostelium discoideum" xref: Reactome:REACT_29011 "Elongation by Pol zeta complex, Gallus gallus" xref: Reactome:REACT_29030 "Formation of C-strand Okazaki fragments, Danio rerio" xref: Reactome:REACT_292 "Resynthesis of excised residue, Homo sapiens" xref: Reactome:REACT_29783 "Insertion of correct bases opposite to the lesion by Pol eta, Gallus gallus" xref: Reactome:REACT_31346 "Elongation by Pol eta, Drosophila melanogaster" xref: Reactome:REACT_31460 "Misinsertion of bases opposite to the lesion by HREV1, Oryza sativa" xref: Reactome:REACT_31614 "POL Beta mediated incorporation of the first replacement nucleotide, Danio rerio" xref: Reactome:REACT_31809 "POL Beta mediated incorporation of the first replacement nucleotide, Mus musculus" xref: Reactome:REACT_32473 "Elongation by Pol eta, Gallus gallus" xref: Reactome:REACT_32478 "Formation of Okazaki fragments, Xenopus tropicalis" xref: Reactome:REACT_32689 "Misinsertion of bases opposite to the lesion by HREV1, Gallus gallus" xref: Reactome:REACT_32853 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Canis familiaris" xref: Reactome:REACT_33072 "Insertion of correct bases opposite to the lesion by Pol eta, Taeniopygia guttata" xref: Reactome:REACT_33294 "Insertion of correct bases opposite to the lesion by Pol eta, Sus scrofa" xref: Reactome:REACT_33524 "Repair synthesis of patch ~27-30 bases long by DNA Pol Delta, Canis familiaris" xref: Reactome:REACT_34369 "Elongation by Pol eta, Caenorhabditis elegans" xref: Reactome:REACT_34392 "Misinsertion of bases opposite to the lesion by HREV1, Sus scrofa" xref: Reactome:REACT_34531 "DNA strand displacement synthesis, Danio rerio" xref: Reactome:REACT_353 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Homo sapiens" xref: Reactome:REACT_36881 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Canis familiaris" xref: Reactome:REACT_41 "DNA strand displacement synthesis, Homo sapiens" xref: Reactome:REACT_465 "Repair synthesis of patch ~27-30 bases long by DNA Pol Delta, Homo sapiens" xref: Reactome:REACT_54850 "POL Beta mediated incorporation of the first replacement nucleotide, Canis familiaris" xref: Reactome:REACT_677 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Homo sapiens" xref: Reactome:REACT_68438 "Formation of Okazaki fragments, Schizosaccharomyces pombe" xref: Reactome:REACT_77128 "Formation of C-strand Okazaki fragments, Oryza sativa" xref: Reactome:REACT_77463 "Misinsertion of bases opposite to the lesion by HREV1, Caenorhabditis elegans" xref: Reactome:REACT_77925 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Plasmodium falciparum" xref: Reactome:REACT_78145 "Resynthesis of excised residue, Canis familiaris" xref: Reactome:REACT_78146 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Taeniopygia guttata" xref: Reactome:REACT_78405 "Formation of Okazaki fragments, Danio rerio" xref: Reactome:REACT_78413 "Misinsertion of bases opposite to the lesion by HREV1, Schizosaccharomyces pombe" xref: Reactome:REACT_78425 "DNA strand displacement synthesis, Xenopus tropicalis" xref: Reactome:REACT_78678 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Mus musculus" xref: Reactome:REACT_78735 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Gallus gallus" xref: Reactome:REACT_78796 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Caenorhabditis elegans" xref: Reactome:REACT_79308 "Elongation by Pol eta, Taeniopygia guttata" xref: Reactome:REACT_79568 "Elongation by HREV1 protein, Mycobacterium tuberculosis" xref: Reactome:REACT_79756 "Resynthesis of excised residue, Bos taurus" xref: Reactome:REACT_79977 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Saccharomyces cerevisiae" xref: Reactome:REACT_80037 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Danio rerio" xref: Reactome:REACT_8004 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Homo sapiens" xref: Reactome:REACT_80054 "Elongation by Pol eta, Bos taurus" xref: Reactome:REACT_80171 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Taeniopygia guttata" xref: Reactome:REACT_8029 "Formation of C-strand Okazaki fragments, Homo sapiens" xref: Reactome:REACT_80471 "Repair synthesis of patch ~27-30 bases long by DNA Pol Delta, Mus musculus" xref: Reactome:REACT_80487 "Elongation by Pol eta, Schizosaccharomyces pombe" xref: Reactome:REACT_80495 "Insertion of correct bases opposite to the lesion by Pol eta, Mus musculus" xref: Reactome:REACT_80499 "Elongation by Pol eta, Mycobacterium tuberculosis" xref: Reactome:REACT_80513 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Dictyostelium discoideum" xref: Reactome:REACT_80712 "Misinsertion of bases opposite to the lesion by HREV1, Mus musculus" xref: Reactome:REACT_80802 "Resynthesis of excised residue, Dictyostelium discoideum" xref: Reactome:REACT_81020 "Insertion of correct bases opposite to the lesion by Pol eta, Caenorhabditis elegans" xref: Reactome:REACT_81188 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Gallus gallus" xref: Reactome:REACT_81625 "DNA strand displacement synthesis, Oryza sativa" xref: Reactome:REACT_81807 "Insertion of correct bases opposite to the lesion by Pol eta, Mycobacterium tuberculosis" xref: Reactome:REACT_81927 "Resynthesis of excised residue, Danio rerio" xref: Reactome:REACT_81968 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Sus scrofa" xref: Reactome:REACT_82001 "Misinsertion of bases opposite to the lesion by HREV1, Arabidopsis thaliana" xref: Reactome:REACT_82035 "Misinsertion of bases opposite to the lesion by HREV1, Canis familiaris" xref: Reactome:REACT_82077 "Insertion of correct bases opposite to the lesion by Pol eta, Danio rerio" xref: Reactome:REACT_82208 "Elongation by HREV1 protein, Sus scrofa" xref: Reactome:REACT_82246 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Drosophila melanogaster" xref: Reactome:REACT_82557 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Mus musculus" xref: Reactome:REACT_82934 "Elongation by Pol zeta complex, Rattus norvegicus" xref: Reactome:REACT_83390 "Elongation by HREV1 protein, Gallus gallus" xref: Reactome:REACT_83447 "Elongation by Pol zeta complex, Canis familiaris" xref: Reactome:REACT_83674 "Elongation by Pol eta, Saccharomyces cerevisiae" xref: Reactome:REACT_83763 "Elongation by Pol eta, Mus musculus" xref: Reactome:REACT_83918 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Sus scrofa" xref: Reactome:REACT_84028 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Rattus norvegicus" xref: Reactome:REACT_84123 "DNA strand displacement synthesis, Mus musculus" xref: Reactome:REACT_84407 "Elongation by HREV1 protein, Saccharomyces cerevisiae" xref: Reactome:REACT_84633 "Formation of Okazaki fragments, Canis familiaris" xref: Reactome:REACT_84853 "Misinsertion of bases opposite to the lesion by HREV1, Danio rerio" xref: Reactome:REACT_84864 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Mus musculus" xref: Reactome:REACT_85325 "Formation of Okazaki fragments, Bos taurus" xref: Reactome:REACT_85611 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Saccharomyces cerevisiae" xref: Reactome:REACT_86134 "Insertion of correct bases opposite to the lesion by Pol eta, Schizosaccharomyces pombe" xref: Reactome:REACT_86652 "Elongation by HREV1 protein, Mus musculus" xref: Reactome:REACT_867 "Elongation by HREV1 protein, Homo sapiens" xref: Reactome:REACT_86753 "Repair synthesis of patch ~27-30 bases long by DNA Pol Delta, Xenopus tropicalis" xref: Reactome:REACT_87271 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Xenopus tropicalis" xref: Reactome:REACT_87439 "DNA strand displacement synthesis, Bos taurus" xref: Reactome:REACT_87801 "Misinsertion of bases opposite to the lesion by HREV1, Mycobacterium tuberculosis" xref: Reactome:REACT_88067 "Elongation by Pol zeta complex, Bos taurus" xref: Reactome:REACT_88473 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Oryza sativa" xref: Reactome:REACT_88663 "Insertion of correct bases opposite to the lesion by Pol eta, Oryza sativa" xref: Reactome:REACT_88811 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Danio rerio" xref: Reactome:REACT_88997 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Plasmodium falciparum" xref: Reactome:REACT_89118 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Mus musculus" xref: Reactome:REACT_89129 "DNA strand displacement synthesis, Canis familiaris" xref: Reactome:REACT_89399 "Formation of Okazaki fragments, Rattus norvegicus" xref: Reactome:REACT_89782 "POL Beta mediated incorporation of the first replacement nucleotide, Rattus norvegicus" xref: Reactome:REACT_89896 "Formation of C-strand Okazaki fragments, Bos taurus" xref: Reactome:REACT_8992 "Synthesis of full-length duplex viral DNA with a discontinuous plus strand, Homo sapiens" xref: Reactome:REACT_90310 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Xenopus tropicalis" xref: Reactome:REACT_90511 "Misinsertion of bases opposite to the lesion by HREV1, Saccharomyces cerevisiae" xref: Reactome:REACT_90564 "DNA strand displacement synthesis, Sus scrofa" xref: Reactome:REACT_90691 "Insertion of correct bases opposite to the lesion by Pol eta, Canis familiaris" xref: Reactome:REACT_9075 "3' PPT-primed initiation of plus-strand DNA synthesis, Homo sapiens" xref: Reactome:REACT_91 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Homo sapiens" xref: Reactome:REACT_91123 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin, Danio rerio" xref: Reactome:REACT_91124 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Caenorhabditis elegans" xref: Reactome:REACT_91218 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Oryza sativa" xref: Reactome:REACT_91365 "Formation of C-strand Okazaki fragments, Rattus norvegicus" xref: Reactome:REACT_91536 "Elongation by Pol eta, Oryza sativa" xref: Reactome:REACT_91619 "Elongation by Pol eta, Canis familiaris" xref: Reactome:REACT_91873 "POL Beta mediated incorporation of the first replacement nucleotide, Xenopus tropicalis" xref: Reactome:REACT_91890 "Repair synthesis for gap-filling by DNA pol delta in TC-NER, Rattus norvegicus" xref: Reactome:REACT_92243 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Rattus norvegicus" xref: Reactome:REACT_92358 "POL Beta mediated incorporation of the first replacement nucleotide, Sus scrofa" xref: Reactome:REACT_92410 "POL Beta mediated incorporation of the first replacement nucleotide, Dictyostelium discoideum" xref: Reactome:REACT_92575 "Repair synthesis for gap-filling by DNA pol epsilon in TC-NER, Bos taurus" xref: Reactome:REACT_92627 "Elongation by Pol eta, Danio rerio" xref: Reactome:REACT_92680 "Elongation by Pol zeta complex, Arabidopsis thaliana" xref: Reactome:REACT_93171 "Repair synthesis for gap-filling by DNA pol delta in TC-NER, Mus musculus" xref: Reactome:REACT_93535 "Formation of C-strand Okazaki fragments, Arabidopsis thaliana" xref: Reactome:REACT_93828 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Canis familiaris" xref: Reactome:REACT_94081 "Elongation by Pol zeta complex, Drosophila melanogaster" xref: Reactome:REACT_94622 "POL Beta mediated incorporation of the first replacement nucleotide, Bos taurus" xref: Reactome:REACT_95001 "Formation of Okazaki fragments, Sus scrofa" xref: Reactome:REACT_95443 "DNA strand displacement synthesis, Rattus norvegicus" xref: Reactome:REACT_95853 "Resynthesis of excised residue, Xenopus tropicalis" xref: Reactome:REACT_96429 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Arabidopsis thaliana" xref: Reactome:REACT_96549 "Repair synthesis for gap-filling by DNA pol delta in TC-NER, Bos taurus" xref: Reactome:REACT_97064 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere, Bos taurus" xref: Reactome:REACT_97260 "Formation of C-strand Okazaki fragments, Xenopus tropicalis" xref: Reactome:REACT_97598 "Elongation by Pol zeta complex, Schizosaccharomyces pombe" xref: Reactome:REACT_97861 "Elongation by HREV1 protein, Taeniopygia guttata" xref: Reactome:REACT_97874 "Elongation by HREV1 protein, Oryza sativa" xref: Reactome:REACT_97969 "Insertion of correct bases opposite to the lesion by Pol eta, Rattus norvegicus" xref: Reactome:REACT_97975 "Repair synthesis for gap-filling by DNA pol delta in TC-NER, Danio rerio" xref: Reactome:REACT_98393 "Repair synthesis of patch ~27-30 bases long by DNA Pol Delta, Bos taurus" xref: Reactome:REACT_98499 "Repair synthesis of ~27-30 bases long patch by DNA Pol Epsilon, Xenopus tropicalis" xref: Reactome:REACT_98529 "Elongation by HREV1 protein, Danio rerio" xref: Reactome:REACT_99265 "Elongation by Pol zeta complex, Danio rerio" is_a: GO:0034061 ! DNA polymerase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0003896 name: DNA primase activity namespace: molecular_function alt_id: GO:0003897 alt_id: GO:0003898 def: "Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases." [GOC:mah, GOC:mcc, ISBN:0716720094, PMID:26184436] subset: gosubset_prok xref: EC:2.7.7.- is_a: GO:0003899 ! DNA-directed RNA polymerase activity relationship: part_of GO:0006269 ! DNA replication, synthesis of RNA primer property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0003899 name: DNA-directed RNA polymerase activity namespace: molecular_function alt_id: GO:0000129 def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6] subset: gosubset_prok synonym: "C ribonucleic acid formation factors" RELATED [EC:2.7.7.6] synonym: "C RNA formation factors" RELATED [EC:2.7.7.6] synonym: "deoxyribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [EC:2.7.7.6] synonym: "DNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.6] synonym: "DNA-dependent RNA nucleotidyltransferase activity" EXACT [EC:2.7.7.6] synonym: "DNA-dependent RNA polymerase activity" EXACT [EC:2.7.7.6] synonym: "DNA-directed RNA polymerase I activity" NARROW [] synonym: "DNA-directed RNA polymerase II activity" NARROW [] synonym: "DNA-directed RNA polymerase III activity" NARROW [] synonym: "nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.6] synonym: "RNA nucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.6] synonym: "RNA polymerase I activity" NARROW [EC:2.7.7.6] synonym: "RNA polymerase II activity" NARROW [EC:2.7.7.6] synonym: "RNA polymerase III activity" NARROW [EC:2.7.7.6] synonym: "transcriptase" BROAD [EC:2.7.7.6] xref: EC:2.7.7.6 xref: MetaCyc:DNA-DIRECTED-RNA-POLYMERASE-RXN xref: Reactome:REACT_100344 "Addition of Nucleotides 5 through 9 on the growing Transcript, Drosophila melanogaster" xref: Reactome:REACT_100410 "Addition of nucleotides between position +11 and +30, Bos taurus" xref: Reactome:REACT_101111 "Addition of the third nucleotide on the nascent transcript, Saccharomyces cerevisiae" xref: Reactome:REACT_101858 "Elongation of pre-rRNA transcript, Taeniopygia guttata" xref: Reactome:REACT_101953 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Oryza sativa" xref: Reactome:REACT_101994 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Xenopus tropicalis" xref: Reactome:REACT_102121 "Addition of the third nucleotide on the nascent transcript, Rattus norvegicus" xref: Reactome:REACT_102441 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Gallus gallus" xref: Reactome:REACT_102466 "Addition of nucleotides between position +11 and +30, Rattus norvegicus" xref: Reactome:REACT_102706 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Rattus norvegicus" xref: Reactome:REACT_102769 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Schizosaccharomyces pombe" xref: Reactome:REACT_102802 "Pol II mediated transcription of microRNA genes, Saccharomyces cerevisiae" xref: Reactome:REACT_102951 "Elongation of pre-rRNA transcript, Drosophila melanogaster" xref: Reactome:REACT_103006 "Elongation of pre-rRNA transcript, Rattus norvegicus" xref: Reactome:REACT_103501 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Xenopus tropicalis" xref: Reactome:REACT_103871 "Addition of nucleotides between position +11 and +30, Gallus gallus" xref: Reactome:REACT_103959 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Rattus norvegicus" xref: Reactome:REACT_104171 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Danio rerio" xref: Reactome:REACT_104334 "Addition of nucleotides between position +11 and +30, Canis familiaris" xref: Reactome:REACT_104618 "Pol II mediated transcription of microRNA genes, Oryza sativa" xref: Reactome:REACT_105022 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Drosophila melanogaster" xref: Reactome:REACT_105177 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Mus musculus" xref: Reactome:REACT_105539 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Gallus gallus" xref: Reactome:REACT_105890 "Pol II mediated transcription of microRNA genes, Taeniopygia guttata" xref: Reactome:REACT_106497 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Plasmodium falciparum" xref: Reactome:REACT_106762 "Addition of Nucleotides 5 through 9 on the growing Transcript, Mus musculus" xref: Reactome:REACT_106790 "Addition of Nucleotides 5 through 9 on the growing Transcript, Danio rerio" xref: Reactome:REACT_108159 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Dictyostelium discoideum" xref: Reactome:REACT_1082 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Homo sapiens" xref: Reactome:REACT_108279 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Rattus norvegicus" xref: Reactome:REACT_108323 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Plasmodium falciparum" xref: Reactome:REACT_108648 "Addition of the third nucleotide on the nascent transcript, Arabidopsis thaliana" xref: Reactome:REACT_109090 "Addition of nucleotides between position +11 and +30, Saccharomyces cerevisiae" xref: Reactome:REACT_109161 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Arabidopsis thaliana" xref: Reactome:REACT_110305 "Pol II mediated transcription of microRNA genes, Danio rerio" xref: Reactome:REACT_110458 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Canis familiaris" xref: Reactome:REACT_110741 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Saccharomyces cerevisiae" xref: Reactome:REACT_112737 "Addition of Nucleotides 5 through 9 on the growing Transcript, Gallus gallus" xref: Reactome:REACT_112968 "Elongation of pre-rRNA transcript, Oryza sativa" xref: Reactome:REACT_113943 "Elongation of pre-rRNA transcript, Gallus gallus" xref: Reactome:REACT_12505 "Pol II mediated transcription of microRNA genes, Homo sapiens" xref: Reactome:REACT_1611 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Homo sapiens" xref: Reactome:REACT_1817 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Homo sapiens" xref: Reactome:REACT_209 "Addition of nucleotides between position +11 and +30, Homo sapiens" xref: Reactome:REACT_28131 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Drosophila melanogaster" xref: Reactome:REACT_28303 "Addition of nucleotides between position +11 and +30, Arabidopsis thaliana" xref: Reactome:REACT_28467 "Pol II mediated transcription of microRNA genes, Caenorhabditis elegans" xref: Reactome:REACT_28810 "Addition of the third nucleotide on the nascent transcript, Oryza sativa" xref: Reactome:REACT_28970 "Addition of nucleotides between position +11 and +30, Oryza sativa" xref: Reactome:REACT_29155 "Addition of the third nucleotide on the nascent transcript, Drosophila melanogaster" xref: Reactome:REACT_29681 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Oryza sativa" xref: Reactome:REACT_29818 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Oryza sativa" xref: Reactome:REACT_30335 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Caenorhabditis elegans" xref: Reactome:REACT_31554 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Schizosaccharomyces pombe" xref: Reactome:REACT_31831 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Caenorhabditis elegans" xref: Reactome:REACT_32533 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Caenorhabditis elegans" xref: Reactome:REACT_32905 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Arabidopsis thaliana" xref: Reactome:REACT_34518 "Elongation of pre-rRNA transcript, Sus scrofa" xref: Reactome:REACT_40 "Addition of the third nucleotide on the nascent transcript, Homo sapiens" xref: Reactome:REACT_581 "Addition of Nucleotides 5 through 9 on the growing Transcript, Homo sapiens" xref: Reactome:REACT_6172 "Addition of nucleotides 5 through 9 on the growing HIV-1 transcript, Homo sapiens" xref: Reactome:REACT_6184 "Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition, Homo sapiens" xref: Reactome:REACT_6208 "Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition, Homo sapiens" xref: Reactome:REACT_6240 "Addition of nucleotides between position +11 and +30 on HIV-1 transcript, Homo sapiens" xref: Reactome:REACT_6325 "Addition of the third nucleotide on the nascent HIV-1 transcript, Homo sapiens" xref: Reactome:REACT_77161 "Pol II mediated transcription of microRNA genes, Gallus gallus" xref: Reactome:REACT_77417 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Danio rerio" xref: Reactome:REACT_77879 "Addition of nucleotides between position +11 and +30, Drosophila melanogaster" xref: Reactome:REACT_78158 "Elongation of pre-rRNA transcript, Bos taurus" xref: Reactome:REACT_79759 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Mus musculus" xref: Reactome:REACT_7998 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Homo sapiens" xref: Reactome:REACT_80162 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Xenopus tropicalis" xref: Reactome:REACT_80268 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Danio rerio" xref: Reactome:REACT_80325 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Danio rerio" xref: Reactome:REACT_80396 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Mus musculus" xref: Reactome:REACT_80464 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Dictyostelium discoideum" xref: Reactome:REACT_80532 "Addition of the third nucleotide on the nascent transcript, Gallus gallus" xref: Reactome:REACT_80605 "Addition of the third nucleotide on the nascent transcript, Mus musculus" xref: Reactome:REACT_80768 "Elongation of pre-rRNA transcript, Schizosaccharomyces pombe" xref: Reactome:REACT_80999 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Schizosaccharomyces pombe" xref: Reactome:REACT_81126 "Addition of the third nucleotide on the nascent transcript, Schizosaccharomyces pombe" xref: Reactome:REACT_81250 "Elongation of pre-rRNA transcript, Canis familiaris" xref: Reactome:REACT_81257 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Schizosaccharomyces pombe" xref: Reactome:REACT_82798 "Addition of nucleotides between position +11 and +30, Schizosaccharomyces pombe" xref: Reactome:REACT_83185 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Canis familiaris" xref: Reactome:REACT_83805 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Drosophila melanogaster" xref: Reactome:REACT_84137 "Pol II mediated transcription of microRNA genes, Plasmodium falciparum" xref: Reactome:REACT_84172 "Pol II mediated transcription of microRNA genes, Xenopus tropicalis" xref: Reactome:REACT_85303 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Arabidopsis thaliana" xref: Reactome:REACT_85444 "Pol II mediated transcription of microRNA genes, Bos taurus" xref: Reactome:REACT_86290 "Elongation of pre-rRNA transcript, Mus musculus" xref: Reactome:REACT_86701 "Pol II mediated transcription of microRNA genes, Dictyostelium discoideum" xref: Reactome:REACT_86831 "Elongation of pre-rRNA transcript, Xenopus tropicalis" xref: Reactome:REACT_87150 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Rattus norvegicus" xref: Reactome:REACT_872 "Elongation of pre-rRNA transcript, Homo sapiens" xref: Reactome:REACT_87708 "Addition of nucleotides between position +11 and +30, Mus musculus" xref: Reactome:REACT_88237 "Addition of nucleotides between position +11 and +30, Xenopus tropicalis" xref: Reactome:REACT_88362 "Addition of the third nucleotide on the nascent transcript, Caenorhabditis elegans" xref: Reactome:REACT_88577 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Arabidopsis thaliana" xref: Reactome:REACT_89363 "Addition of the third nucleotide on the nascent transcript, Xenopus tropicalis" xref: Reactome:REACT_89527 "Addition of Nucleotides 5 through 9 on the growing Transcript, Rattus norvegicus" xref: Reactome:REACT_89539 "Pol II mediated transcription of microRNA genes, Arabidopsis thaliana" xref: Reactome:REACT_90076 "Addition of nucleotides between position +11 and +30, Caenorhabditis elegans" xref: Reactome:REACT_90432 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Caenorhabditis elegans" xref: Reactome:REACT_90456 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Xenopus tropicalis" xref: Reactome:REACT_91185 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Bos taurus" xref: Reactome:REACT_91186 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Drosophila melanogaster" xref: Reactome:REACT_91701 "Pol II mediated transcription of microRNA genes, Drosophila melanogaster" xref: Reactome:REACT_91945 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Saccharomyces cerevisiae" xref: Reactome:REACT_93006 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Bos taurus" xref: Reactome:REACT_93214 "Addition of Nucleotides 5 through 9 on the growing Transcript, Xenopus tropicalis" xref: Reactome:REACT_93674 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Dictyostelium discoideum" xref: Reactome:REACT_94323 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere, Canis familiaris" xref: Reactome:REACT_95240 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Saccharomyces cerevisiae" xref: Reactome:REACT_95273 "Pol II mediated transcription of microRNA genes, Canis familiaris" xref: Reactome:REACT_95718 "Pol II mediated transcription of microRNA genes, Rattus norvegicus" xref: Reactome:REACT_95942 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Saccharomyces cerevisiae" xref: Reactome:REACT_96380 "Addition of nucleotides between position +11 and +30, Danio rerio" xref: Reactome:REACT_97333 "Pol II mediated transcription of microRNA genes, Schizosaccharomyces pombe" xref: Reactome:REACT_97557 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Bos taurus" xref: Reactome:REACT_97977 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Mus musculus" xref: Reactome:REACT_98273 "Addition of the third nucleotide on the nascent transcript, Dictyostelium discoideum" xref: Reactome:REACT_98842 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition, Dictyostelium discoideum" xref: Reactome:REACT_98844 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin, Oryza sativa" xref: Reactome:REACT_98898 "Pol II mediated transcription of microRNA genes, Mus musculus" xref: Reactome:REACT_99037 "Elongation of pre-rRNA transcript, Caenorhabditis elegans" xref: Reactome:REACT_99120 "Addition of the third nucleotide on the nascent transcript, Danio rerio" xref: Reactome:REACT_99215 "Addition of nucleotides between position +11 and +30, Dictyostelium discoideum" xref: Reactome:REACT_99300 "Addition of Nucleotides 5 through 9 on the growing Transcript, Bos taurus" xref: Reactome:REACT_99424 "Elongation of pre-rRNA transcript, Danio rerio" is_a: GO:0034062 ! RNA polymerase activity relationship: part_of GO:0032774 ! RNA biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0003905 name: alkylbase DNA N-glycosylase activity namespace: molecular_function alt_id: GO:0004036 def: "Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site." [EC:3.2.2.21, GOC:elh, PMID:10872450, PMID:9224623] subset: gosubset_prok synonym: "3-methyladenine DNA glycosylase II" RELATED [EC:3.2.2.21] synonym: "AlkA" RELATED [EC:3.2.2.21] synonym: "alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)" BROAD [EC:3.2.2.21] synonym: "alkylbase DNA glycosidase activity" EXACT [] synonym: "deoxyribonucleate 3-methyladenine glycosidase II" RELATED [EC:3.2.2.21] synonym: "DNA glycosidase II activity" EXACT [EC:3.2.2.21] synonym: "DNA-3-methyladenine glycosidase II activity" EXACT [] synonym: "DNA-3-methyladenine glycosylase II" RELATED [EC:3.2.2.21] xref: EC:3.2.2.21 xref: MetaCyc:3.2.2.21-RXN is_a: GO:0019104 ! DNA N-glycosylase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0003916 name: DNA topoisomerase activity namespace: molecular_function alt_id: GO:0009387 def: "Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA." [GOC:mah, PMID:8811192] subset: gosubset_prok xref: EC:5.99.1.- xref: MetaCyc:5.99.1.2-RXN is_a: GO:0016853 ! isomerase activity relationship: has_part GO:0003677 ! DNA binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0003917 name: DNA topoisomerase type I activity namespace: molecular_function def: "Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle." [PMID:8811192] comment: Note that a further distinction, between type IA and type IB topoisomerases, is based on sequence or structural similarity between gene products that possess type I catalytic activity. subset: gosubset_prok synonym: "deoxyribonucleate topoisomerase" BROAD [EC:5.99.1.2] synonym: "DNA topoisomerase I activity" NARROW [] synonym: "nicking-closing enzyme activity" RELATED [EC:5.99.1.2] synonym: "omega-protein activity" RELATED [EC:5.99.1.2] synonym: "relaxing enzyme activity" RELATED [EC:5.99.1.2] synonym: "swivelase activity" RELATED [EC:5.99.1.2] synonym: "topoisomerase" BROAD [EC:5.99.1.2] synonym: "type I DNA topoisomerase activity" EXACT [] synonym: "type I topoisomerase activity" EXACT [] synonym: "untwisting enzyme activity" RELATED [EC:5.99.1.2] xref: EC:5.99.1.2 xref: MetaCyc:5.99.1.2-RXN is_a: GO:0003916 ! DNA topoisomerase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0003924 name: GTPase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast subset: gosubset_prok synonym: "ARF small monomeric GTPase activity" NARROW [] synonym: "dynamin GTPase activity" NARROW [] synonym: "heterotrimeric G-protein GTPase activity" NARROW [] synonym: "heterotrimeric G-protein GTPase, alpha-subunit" RELATED [] synonym: "heterotrimeric G-protein GTPase, beta-subunit" RELATED [] synonym: "heterotrimeric G-protein GTPase, gamma-subunit" RELATED [] synonym: "hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement" BROAD [] synonym: "protein-synthesizing GTPase activity" NARROW [] synonym: "protein-synthesizing GTPase activity, elongation" NARROW [] synonym: "protein-synthesizing GTPase activity, initiation" NARROW [] synonym: "protein-synthesizing GTPase activity, termination" NARROW [] synonym: "Rab small monomeric GTPase activity" NARROW [] synonym: "Ran small monomeric GTPase activity" NARROW [] synonym: "Ras small monomeric GTPase activity" NARROW [] synonym: "RHEB small monomeric GTPase activity" NARROW [] synonym: "Rho small monomeric GTPase activity" NARROW [] synonym: "Sar small monomeric GTPase activity" NARROW [] synonym: "signal-recognition-particle GTPase activity" NARROW [] synonym: "small monomeric GTPase activity" NARROW [] synonym: "tubulin GTPase activity" NARROW [] xref: Reactome:REACT_100432 "trans-Golgi Network Vesicle Scission, Mus musculus" xref: Reactome:REACT_100708 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Bos taurus" xref: Reactome:REACT_101121 "trans-Golgi Network Vesicle Scission, Rattus norvegicus" xref: Reactome:REACT_101520 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Drosophila melanogaster" xref: Reactome:REACT_101563 "Loss of Sar1b GTPase, Arabidopsis thaliana" xref: Reactome:REACT_101678 "G-protein alpha subunit is inactivated, Gallus gallus" xref: Reactome:REACT_102040 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Xenopus tropicalis" xref: Reactome:REACT_102208 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Danio rerio" xref: Reactome:REACT_102307 "Adenylate cyclase increases the GTPase activity of Gi alpha, Gallus gallus" xref: Reactome:REACT_102371 "Vesicle Uncoating, Oryza sativa" xref: Reactome:REACT_102510 "trans-Golgi Network Vesicle Scission, Bos taurus" xref: Reactome:REACT_102532 "Loss of Sar1b GTPase, Danio rerio" xref: Reactome:REACT_103518 "trans-Golgi Network Lysosomal Vesicle Scission, Sus scrofa" xref: Reactome:REACT_104081 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Mus musculus" xref: Reactome:REACT_104477 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Canis familiaris" xref: Reactome:REACT_104739 "Loss of Sar1b GTPase, Dictyostelium discoideum" xref: Reactome:REACT_105323 "trans-Golgi Network Vesicle Scission, Canis familiaris" xref: Reactome:REACT_105697 "G-protein alpha subunit is inactivated, Saccharomyces cerevisiae" xref: Reactome:REACT_105708 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Xenopus tropicalis" xref: Reactome:REACT_105854 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Taeniopygia guttata" xref: Reactome:REACT_106121 "Vesicle Uncoating, Saccharomyces cerevisiae" xref: Reactome:REACT_106217 "Hydrolysis of eEF1A:GTP, Dictyostelium discoideum" xref: Reactome:REACT_106301 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Mus musculus" xref: Reactome:REACT_106528 "trans-Golgi Network Lysosomal Vesicle Scission, Canis familiaris" xref: Reactome:REACT_107176 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Taeniopygia guttata" xref: Reactome:REACT_107306 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Rattus norvegicus" xref: Reactome:REACT_107730 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Saccharomyces cerevisiae" xref: Reactome:REACT_107820 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Canis familiaris" xref: Reactome:REACT_108363 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Drosophila melanogaster" xref: Reactome:REACT_108653 "G-protein alpha subunit is inactivated, Bos taurus" xref: Reactome:REACT_108825 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Drosophila melanogaster" xref: Reactome:REACT_108837 "trans-Golgi Network Vesicle Scission, Xenopus tropicalis" xref: Reactome:REACT_109360 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Sus scrofa" xref: Reactome:REACT_109897 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Danio rerio" xref: Reactome:REACT_110131 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Gallus gallus" xref: Reactome:REACT_110443 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Xenopus tropicalis" xref: Reactome:REACT_110557 "trans-Golgi Network Vesicle Scission, Danio rerio" xref: Reactome:REACT_110859 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Caenorhabditis elegans" xref: Reactome:REACT_110879 "G-protein alpha subunit is inactivated, Canis familiaris" xref: Reactome:REACT_110931 "G-protein alpha subunit is inactivated, Sus scrofa" xref: Reactome:REACT_111994 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Xenopus tropicalis" xref: Reactome:REACT_112104 "Endocytosis (internalization) of clathrin-coated vesicle, Sus scrofa" xref: Reactome:REACT_112254 "Endocytosis (internalization) of clathrin-coated vesicle, Xenopus tropicalis" xref: Reactome:REACT_112389 "Disassembly of COPII coated vesicle, Gallus gallus" xref: Reactome:REACT_112587 "trans-Golgi Network Vesicle Scission, Schizosaccharomyces pombe" xref: Reactome:REACT_112651 "Vesicle Uncoating, Xenopus tropicalis" xref: Reactome:REACT_112671 "Vesicle Uncoating, Plasmodium falciparum" xref: Reactome:REACT_113058 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Saccharomyces cerevisiae" xref: Reactome:REACT_113209 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Schizosaccharomyces pombe" xref: Reactome:REACT_113727 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Saccharomyces cerevisiae" xref: Reactome:REACT_113832 "Formation of clathrin coated vesicle, Bos taurus" xref: Reactome:REACT_113952 "Formation of clathrin coated vesicle, Schizosaccharomyces pombe" xref: Reactome:REACT_113954 "Endocytosis (internalization) of clathrin-coated vesicle, Schizosaccharomyces pombe" xref: Reactome:REACT_114148 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Schizosaccharomyces pombe" xref: Reactome:REACT_114153 "Loss of Sar1b GTPase, Xenopus tropicalis" xref: Reactome:REACT_114188 "Formation of clathrin coated vesicle, Sus scrofa" xref: Reactome:REACT_114210 "G-protein alpha subunit is inactivated, Schizosaccharomyces pombe" xref: Reactome:REACT_114331 "trans-Golgi Network Vesicle Scission, Taeniopygia guttata" xref: Reactome:REACT_114379 "Formation of clathrin coated vesicle, Taeniopygia guttata" xref: Reactome:REACT_114384 "Hydrolysis of eEF1A:GTP, Gallus gallus" xref: Reactome:REACT_114532 "Formation of clathrin coated vesicle, Xenopus tropicalis" xref: Reactome:REACT_114620 "Endocytosis (internalization) of clathrin-coated vesicle, Taeniopygia guttata" xref: Reactome:REACT_114824 "trans-Golgi Network Lysosomal Vesicle Scission, Taeniopygia guttata" xref: Reactome:REACT_115229 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Schizosaccharomyces pombe" xref: Reactome:REACT_115324 "Endocytosis (internalization) of clathrin-coated vesicle, Bos taurus" xref: Reactome:REACT_12396 "Loss of Sar1b GTPase, Homo sapiens" xref: Reactome:REACT_12397 "Endocytosis (internalization) of clathrin-coated vesicle, Homo sapiens" xref: Reactome:REACT_12456 "Vesicle Uncoating, Homo sapiens" xref: Reactome:REACT_12612 "Endocytosis of clathrin-coated vesicle, Rattus norvegicus" xref: Reactome:REACT_15316 "G-protein alpha subunit is inactivated, Homo sapiens" xref: Reactome:REACT_15335 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Homo sapiens" xref: Reactome:REACT_15449 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Homo sapiens" xref: Reactome:REACT_15495 "Adenylate cyclase increases the GTPase activity of Gi alpha, Homo sapiens" xref: Reactome:REACT_19123 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Homo sapiens" xref: Reactome:REACT_19178 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Homo sapiens" xref: Reactome:REACT_19186 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Homo sapiens" xref: Reactome:REACT_19194 "trans-Golgi Network Lysosomal Vesicle Scission, Homo sapiens" xref: Reactome:REACT_19219 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Homo sapiens" xref: Reactome:REACT_19255 "trans-Golgi Network Vesicle Scission, Homo sapiens" xref: Reactome:REACT_19317 "G alpha (i)1 auto-inactivates by hydrolysing GTP to GDP, Rattus norvegicus" xref: Reactome:REACT_22359 "Formation of clathrin coated vesicle, Homo sapiens" xref: Reactome:REACT_28065 "Vesicle Uncoating, Sus scrofa" xref: Reactome:REACT_28251 "Hydrolysis of eEF1A:GTP, Danio rerio" xref: Reactome:REACT_28269 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Gallus gallus" xref: Reactome:REACT_29162 "trans-Golgi Network Lysosomal Vesicle Scission, Mus musculus" xref: Reactome:REACT_30456 "Hydrolysis of eEF1A:GTP, Plasmodium falciparum" xref: Reactome:REACT_30463 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Bos taurus" xref: Reactome:REACT_30562 "Endocytosis (internalization) of clathrin-coated vesicle, Caenorhabditis elegans" xref: Reactome:REACT_30687 "G-protein alpha subunit is inactivated, Xenopus tropicalis" xref: Reactome:REACT_30707 "trans-Golgi Network Vesicle Scission, Caenorhabditis elegans" xref: Reactome:REACT_30942 "Vesicle Uncoating, Rattus norvegicus" xref: Reactome:REACT_31226 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Mus musculus" xref: Reactome:REACT_31474 "Formation of clathrin coated vesicle, Danio rerio" xref: Reactome:REACT_31530 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Caenorhabditis elegans" xref: Reactome:REACT_31599 "trans-Golgi Network Lysosomal Vesicle Scission, Danio rerio" xref: Reactome:REACT_31709 "Hydrolysis of eEF1A:GTP, Drosophila melanogaster" xref: Reactome:REACT_31727 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Taeniopygia guttata" xref: Reactome:REACT_31850 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Gallus gallus" xref: Reactome:REACT_32006 "Loss of Sar1b GTPase, Canis familiaris" xref: Reactome:REACT_32028 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Danio rerio" xref: Reactome:REACT_32914 "Vesicle Uncoating, Dictyostelium discoideum" xref: Reactome:REACT_33948 "trans-Golgi Network Lysosomal Vesicle Scission, Rattus norvegicus" xref: Reactome:REACT_34113 "Vesicle Uncoating, Schizosaccharomyces pombe" xref: Reactome:REACT_34480 "G-protein alpha subunit is inactivated, Caenorhabditis elegans" xref: Reactome:REACT_34592 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Xenopus tropicalis" xref: Reactome:REACT_34735 "Adenylate cyclase increases the GTPase activity of Gi alpha, Taeniopygia guttata" xref: Reactome:REACT_348 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Homo sapiens" xref: Reactome:REACT_36834 "trans-Golgi Network Lysosomal Vesicle Scission, Bos taurus" xref: Reactome:REACT_37542 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Sus scrofa" xref: Reactome:REACT_552 "Hydrolysis of eEF1A:GTP, Homo sapiens" xref: Reactome:REACT_6171 "Hydrolysis of Ran:GTP to Ran:GDP, Homo sapiens" xref: Reactome:REACT_712 "Hydrolysis of reEF1A:GTP, Oryctolagus cuniculus" xref: Reactome:REACT_75799 "Disassembly of COPII coated vesicle, Homo sapiens" xref: Reactome:REACT_77032 "Hydrolysis of eEF1A:GTP, Canis familiaris" xref: Reactome:REACT_77303 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Danio rerio" xref: Reactome:REACT_78069 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Caenorhabditis elegans" xref: Reactome:REACT_78231 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Taeniopygia guttata" xref: Reactome:REACT_78653 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Bos taurus" xref: Reactome:REACT_78945 "G-protein alpha subunit is inactivated, Rattus norvegicus" xref: Reactome:REACT_79558 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Taeniopygia guttata" xref: Reactome:REACT_79620 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Mus musculus" xref: Reactome:REACT_80275 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Bos taurus" xref: Reactome:REACT_80612 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Canis familiaris" xref: Reactome:REACT_81304 "Loss of Sar1b GTPase, Taeniopygia guttata" xref: Reactome:REACT_81448 "Endocytosis (internalization) of clathrin-coated vesicle, Canis familiaris" xref: Reactome:REACT_81580 "Disassembly of COPII coated vesicle, Mus musculus" xref: Reactome:REACT_81664 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Caenorhabditis elegans" xref: Reactome:REACT_81879 "Vesicle Uncoating, Drosophila melanogaster" xref: Reactome:REACT_82203 "Formation of clathrin coated vesicle, Canis familiaris" xref: Reactome:REACT_82263 "G-protein alpha subunit is inactivated, Taeniopygia guttata" xref: Reactome:REACT_82457 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Taeniopygia guttata" xref: Reactome:REACT_82603 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Canis familiaris" xref: Reactome:REACT_82704 "Loss of Sar1b GTPase, Rattus norvegicus" xref: Reactome:REACT_83308 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Rattus norvegicus" xref: Reactome:REACT_83403 "G-protein alpha subunit is inactivated, Drosophila melanogaster" xref: Reactome:REACT_83440 "Hydrolysis of eEF1A:GTP, Schizosaccharomyces pombe" xref: Reactome:REACT_83730 "Loss of Sar1b GTPase, Plasmodium falciparum" xref: Reactome:REACT_84204 "Endocytosis (internalization) of clathrin-coated vesicle, Danio rerio" xref: Reactome:REACT_84553 "Vesicle Uncoating, Canis familiaris" xref: Reactome:REACT_84696 "G-protein alpha subunit is inactivated, Danio rerio" xref: Reactome:REACT_84712 "Hydrolysis of eEF1A:GTP, Saccharomyces cerevisiae" xref: Reactome:REACT_84735 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Rattus norvegicus" xref: Reactome:REACT_85008 "Vesicle Uncoating, Danio rerio" xref: Reactome:REACT_85418 "Loss of Sar1b GTPase, Gallus gallus" xref: Reactome:REACT_85769 "Disassembly of COPII coated vesicle, Danio rerio" xref: Reactome:REACT_85972 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Canis familiaris" xref: Reactome:REACT_86227 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Dictyostelium discoideum" xref: Reactome:REACT_86358 "trans-Golgi Network Lysosomal Vesicle Scission, Caenorhabditis elegans" xref: Reactome:REACT_86400 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Dictyostelium discoideum" xref: Reactome:REACT_86630 "Vesicle Uncoating, Mus musculus" xref: Reactome:REACT_86760 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Gallus gallus" xref: Reactome:REACT_86972 "Loss of Sar1b GTPase, Mus musculus" xref: Reactome:REACT_87409 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Dictyostelium discoideum" xref: Reactome:REACT_87506 "Formation of clathrin coated vesicle, Rattus norvegicus" xref: Reactome:REACT_87558 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Mus musculus" xref: Reactome:REACT_87653 "Endocytosis (internalization) of clathrin-coated vesicle, Mus musculus" xref: Reactome:REACT_87661 "Formation of clathrin coated vesicle, Drosophila melanogaster" xref: Reactome:REACT_88045 "Vesicle Uncoating, Gallus gallus" xref: Reactome:REACT_88357 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Canis familiaris" xref: Reactome:REACT_89231 "Loss of Sar1b GTPase, Bos taurus" xref: Reactome:REACT_89292 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Gallus gallus" xref: Reactome:REACT_89416 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Bos taurus" xref: Reactome:REACT_89668 "trans-Golgi Network Lysosomal Vesicle Scission, Xenopus tropicalis" xref: Reactome:REACT_89763 "Vesicle Uncoating, Taeniopygia guttata" xref: Reactome:REACT_90050 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Mus musculus" xref: Reactome:REACT_90064 "Hydrolysis of eEF1A:GTP, Mus musculus" xref: Reactome:REACT_90517 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Xenopus tropicalis" xref: Reactome:REACT_90703 "G-protein alpha subunit is inactivated, Dictyostelium discoideum" xref: Reactome:REACT_91199 "Adenylate cyclase increases the GTPase activity of Gi alpha, Bos taurus" xref: Reactome:REACT_91588 "trans-Golgi Network Vesicle Scission, Drosophila melanogaster" xref: Reactome:REACT_92176 "Endocytosis (internalization) of clathrin-coated vesicle, Drosophila melanogaster" xref: Reactome:REACT_92197 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Bos taurus" xref: Reactome:REACT_92198 "Loss of Sar1b GTPase, Oryza sativa" xref: Reactome:REACT_92450 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Danio rerio" xref: Reactome:REACT_93249 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Dictyostelium discoideum" xref: Reactome:REACT_93305 "Loss of Sar1b GTPase, Sus scrofa" xref: Reactome:REACT_93641 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Gallus gallus" xref: Reactome:REACT_93742 "G-protein alpha subunit is inactivated, Mus musculus" xref: Reactome:REACT_93772 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Gallus gallus" xref: Reactome:REACT_94019 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Sus scrofa" xref: Reactome:REACT_94095 "trans-Golgi Network Vesicle Scission, Sus scrofa" xref: Reactome:REACT_94305 "Adenylate cyclase increases the GTPase activity of Gi alpha, Xenopus tropicalis" xref: Reactome:REACT_94760 "Adenylate cyclase increases the GTPase activity of Gi alpha, Danio rerio" xref: Reactome:REACT_95238 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Rattus norvegicus" xref: Reactome:REACT_95563 "Adenylate cyclase increases the GTPase activity of Gi alpha, Canis familiaris" xref: Reactome:REACT_96019 "Loss of Sar1b GTPase, Drosophila melanogaster" xref: Reactome:REACT_96132 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Drosophila melanogaster" xref: Reactome:REACT_96223 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Sus scrofa" xref: Reactome:REACT_96612 "Adenylate cyclase increases the GTPase activity of Gi alpha, Rattus norvegicus" xref: Reactome:REACT_96881 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Xenopus tropicalis" xref: Reactome:REACT_97284 "Loss of Sar1b GTPase, Saccharomyces cerevisiae" xref: Reactome:REACT_97405 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Taeniopygia guttata" xref: Reactome:REACT_97595 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Danio rerio" xref: Reactome:REACT_97794 "Loss of Sar1b GTPase, Schizosaccharomyces pombe" xref: Reactome:REACT_98431 "Formation of clathrin coated vesicle, Caenorhabditis elegans" xref: Reactome:REACT_98556 "Vesicle Uncoating, Bos taurus" xref: Reactome:REACT_98837 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Canis familiaris" xref: Reactome:REACT_98859 "Adenylate cyclase increases the GTPase activity of Gi alpha, Mus musculus" xref: Reactome:REACT_99479 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Mus musculus" xref: Reactome:REACT_99533 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Sus scrofa" xref: Reactome:REACT_99616 "Formation of clathrin coated vesicle, Mus musculus" xref: RHEA:19672 is_a: GO:0017111 ! nucleoside-triphosphatase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0003937 name: IMP cyclohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide." [EC:3.5.4.10] subset: gosubset_prok synonym: "IMP 1,2-hydrolase (decyclizing)" EXACT [EC:3.5.4.10] synonym: "IMP synthetase activity" EXACT [EC:3.5.4.10] synonym: "inosinate cyclohydrolase activity" EXACT [EC:3.5.4.10] synonym: "inosinicase activity" EXACT [EC:3.5.4.10] xref: EC:3.5.4.10 xref: MetaCyc:IMPCYCLOHYDROLASE-RXN xref: Reactome:REACT_100264 "FAICAR => IMP + H2O, Mycobacterium tuberculosis" xref: Reactome:REACT_101327 "FAICAR => IMP + H2O, Oryza sativa" xref: Reactome:REACT_101441 "FAICAR => IMP + H2O, Canis familiaris" xref: Reactome:REACT_101852 "FAICAR => IMP + H2O, Caenorhabditis elegans" xref: Reactome:REACT_105279 "FAICAR => IMP + H2O, Danio rerio" xref: Reactome:REACT_107619 "FAICAR => IMP + H2O, Rattus norvegicus" xref: Reactome:REACT_110740 "FAICAR => IMP + H2O, Gallus gallus" xref: Reactome:REACT_116131 "5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) <=> inosine 5'-monophosphate + H2O, Gallus gallus" xref: Reactome:REACT_263 "FAICAR => IMP + H2O, Homo sapiens" xref: Reactome:REACT_29038 "FAICAR => IMP + H2O, Xenopus tropicalis" xref: Reactome:REACT_30340 "FAICAR => IMP + H2O, Bos taurus" xref: Reactome:REACT_30737 "FAICAR => IMP + H2O, Arabidopsis thaliana" xref: Reactome:REACT_79659 "FAICAR => IMP + H2O, Schizosaccharomyces pombe" xref: Reactome:REACT_80364 "FAICAR => IMP + H2O, Dictyostelium discoideum" xref: Reactome:REACT_80795 "FAICAR => IMP + H2O, Sus scrofa" xref: Reactome:REACT_80881 "FAICAR => IMP + H2O, Mus musculus" xref: Reactome:REACT_83814 "FAICAR => IMP + H2O, Drosophila melanogaster" xref: Reactome:REACT_93074 "FAICAR => IMP + H2O, Escherichia coli" xref: Reactome:REACT_93482 "FAICAR => IMP + H2O, Taeniopygia guttata" xref: Reactome:REACT_94292 "FAICAR => IMP + H2O, Staphylococcus aureus N315" xref: Reactome:REACT_98029 "FAICAR => IMP + H2O, Saccharomyces cerevisiae" xref: RHEA:18448 is_a: GO:0019238 ! cyclohydrolase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0003954 name: NADH dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3] subset: gosubset_prok synonym: "beta-NADH dehydrogenase dinucleotide activity" EXACT [EC:1.6.99.3] synonym: "cytochrome c reductase activity" RELATED [EC:1.6.99.3] synonym: "diaphorase activity" BROAD [EC:1.6.99.3] synonym: "dihydrocodehydrogenase I dehydrogenase activity" EXACT [EC:1.6.99.3] synonym: "dihydronicotinamide adenine dinucleotide dehydrogenase activity" EXACT [EC:1.6.99.3] synonym: "diphosphopyridine diaphorase activity" EXACT [EC:1.6.99.3] synonym: "diphosphopyrinase activity" EXACT [EC:1.6.99.3] synonym: "DPNH diaphorase activity" EXACT [EC:1.6.99.3] synonym: "NADH diaphorase activity" EXACT [EC:1.6.99.3] synonym: "NADH hydrogenase activity" EXACT [EC:1.6.99.3] synonym: "NADH oxidoreductase activity" EXACT [EC:1.6.99.3] synonym: "NADH-menadione oxidoreductase activity" NARROW [EC:1.6.99.3] synonym: "NADH2 dehydrogenase activity" EXACT [EC:1.6.99.3] synonym: "NADH:(acceptor) oxidoreductase activity" EXACT [EC:1.6.99.3] synonym: "NADH:acceptor oxidoreductase activity" EXACT [EC:1.6.99.3] synonym: "NADH:cytochrome c oxidoreductase activity" NARROW [EC:1.6.99.3] synonym: "reduced diphosphopyridine nucleotide diaphorase activity" EXACT [EC:1.6.99.3] synonym: "type 1 dehydrogenase activity" RELATED [EC:1.6.99.3] synonym: "type I dehydrogenase activity" RELATED [EC:1.6.99.3] xref: EC:1.6.99.3 xref: MetaCyc:NADH-DEHYDROGENASE-RXN xref: RHEA:11359 is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0003958 name: NADPH-hemoprotein reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein." [EC:1.6.2.4] subset: gosubset_prok synonym: "aldehyde reductase (NADPH-dependent) activity" RELATED [EC:1.6.2.4] synonym: "CPR activity" RELATED [EC:1.6.2.4] synonym: "cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent) activity" NARROW [EC:1.6.2.4] synonym: "cytochrome P-450 reductase activity" EXACT [EC:1.6.2.4] synonym: "cytochrome P450 reductase activity" NARROW [EC:1.6.2.4] synonym: "dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "FAD-cytochrome c reductase activity" RELATED [EC:1.6.2.4] synonym: "ferrihemoprotein P-450 reductase activity" RELATED [EC:1.6.2.4] synonym: "NADP--cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "NADP--cytochrome reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--cytochrome c oxidoreductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--cytochrome P450 oxidoreductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--cytochrome P450 reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--ferricytochrome c oxidoreductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--ferrihemoprotein reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH-cytochrome P-450 oxidoreductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH-cytochrome p-450 reductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH-dependent cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH-ferrihemoprotein reductase activity" EXACT [] synonym: "NADPH:cytochrome c reductase activity" EXACT [] synonym: "NADPH:cytochrome P450 reductase activity" EXACT [] synonym: "NADPH:ferrihemoprotein oxidoreductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH:hemoprotein oxidoreductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH:P-450 reductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH:P450 reductase activity" NARROW [EC:1.6.2.4] synonym: "POR" RELATED [EC:1.6.2.4] synonym: "reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate) activity" NARROW [EC:1.6.2.4] synonym: "TPNH(2) cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "TPNH-cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "TPNH2 cytochrome c reductase activity" EXACT [EC:1.6.2.4] xref: EC:1.6.2.4 xref: MetaCyc:NADPH--FERRIHEMOPROTEIN-REDUCTASE-RXN is_a: GO:0016653 ! oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0003975 name: UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol." [EC:2.7.8.15] subset: gosubset_prok synonym: "chitobiosylpyrophosphoryldolichol synthase activity" EXACT [EC:2.7.8.15] synonym: "dolichol phosphate N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.15] synonym: "GlcNAc-1-P transferase activity" EXACT [EC:2.7.8.15] synonym: "N-acetylglucosamine-1-phosphate transferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-acetylglucosamine-dolichol phosphate acetylglucosamine phosphotransferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-acetylglucosamine-dolichol phosphate acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase activity" EXACT [] synonym: "uridine diphosphoacetylglucosamine-dolichyl phosphate acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.15] xref: EC:2.7.8.15 xref: MetaCyc:2.7.8.15-RXN xref: Reactome:REACT_22147 "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate, Homo sapiens" xref: RHEA:13292 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0003993 name: acid phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2] subset: gosubset_prok synonym: "acid monophosphatase activity" EXACT [EC:3.1.3.2] synonym: "acid nucleoside diphosphate phosphatase activity" EXACT [EC:3.1.3.2] synonym: "acid phosphohydrolase activity" EXACT [EC:3.1.3.2] synonym: "acid phosphomonoester hydrolase activity" EXACT [EC:3.1.3.2] synonym: "acid phosphomonoesterase activity" EXACT [EC:3.1.3.2] synonym: "glycerophosphatase activity" BROAD [EC:3.1.3.2] synonym: "orthophosphoric-monoester phosphohydrolase (acid optimum)" EXACT [EC:3.1.3.2] synonym: "phosphate-monoester phosphohydrolase (acid optimum)" EXACT [EC:3.1.3.2] synonym: "phosphomonoesterase activity" BROAD [EC:3.1.3.2] synonym: "uteroferrin" RELATED [EC:3.1.3.2] xref: EC:3.1.3.2 xref: MetaCyc:ACID-PHOSPHATASE-RXN xref: Reactome:REACT_104847 "FMN can be hydrolyzed back to riboflavin, Mus musculus" xref: Reactome:REACT_11171 "FMN can be hydrolyzed back to riboflavin, Homo sapiens" xref: Reactome:REACT_80951 "FMN can be hydrolyzed back to riboflavin, Plasmodium falciparum" xref: Reactome:REACT_82194 "FMN can be hydrolyzed back to riboflavin, Bos taurus" xref: Reactome:REACT_82472 "FMN can be hydrolyzed back to riboflavin, Xenopus tropicalis" xref: Reactome:REACT_83480 "FMN can be hydrolyzed back to riboflavin, Caenorhabditis elegans" xref: Reactome:REACT_83568 "FMN can be hydrolyzed back to riboflavin, Canis familiaris" xref: Reactome:REACT_84333 "FMN can be hydrolyzed back to riboflavin, Sus scrofa" xref: Reactome:REACT_97154 "FMN can be hydrolyzed back to riboflavin, Danio rerio" xref: Reactome:REACT_97735 "FMN can be hydrolyzed back to riboflavin, Arabidopsis thaliana" xref: Reactome:REACT_99971 "FMN can be hydrolyzed back to riboflavin, Oryza sativa" is_a: GO:0016791 ! phosphatase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0003994 name: aconitate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate." [EC:4.2.1.3, GOC:pde, GOC:vw] comment: This is a process composed of two reactions represented by the terms 'GO:0052632 : citrate hydro-lyase (cis-aconitate-forming) activity' and 'GO:0052633 : isocitrate hydro-lyase (cis-aconitate-forming) activity'. subset: gosubset_prok synonym: "aconitase activity" EXACT [] synonym: "cis-aconitase activity" EXACT [EC:4.2.1.3] synonym: "citrate hydro-lyase activity" BROAD [EC:4.2.1.3] synonym: "citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [EC:4.2.1.3] synonym: "citrate(isocitrate) hydro-lyase activity" EXACT [EC:4.2.1.3] xref: EC:4.2.1.3 xref: Reactome:REACT_106698 "citrate <=> isocitrate, Saccharomyces cerevisiae" xref: Reactome:REACT_115701 "citrate <=> isocitrate, Gallus gallus" xref: Reactome:REACT_116024 "isocitrate <=> citrate, Gallus gallus" xref: Reactome:REACT_1898 "citrate <=> isocitrate, Homo sapiens" xref: Reactome:REACT_21262 "isocitrate <=> citrate, Homo sapiens" xref: Reactome:REACT_30406 "citrate <=> isocitrate, Caenorhabditis elegans" xref: Reactome:REACT_32627 "citrate <=> isocitrate, Rattus norvegicus" xref: Reactome:REACT_46526 "citrate <=> isocitrate, Schizosaccharomyces pombe" xref: Reactome:REACT_77059 "citrate <=> isocitrate, Bos taurus" xref: Reactome:REACT_77875 "citrate <=> isocitrate, Canis familiaris" xref: Reactome:REACT_77983 "citrate <=> isocitrate, Dictyostelium discoideum" xref: Reactome:REACT_78997 "citrate <=> isocitrate, Taeniopygia guttata" xref: Reactome:REACT_81376 "citrate <=> isocitrate, Mus musculus" xref: Reactome:REACT_82548 "citrate <=> isocitrate, Xenopus tropicalis" xref: Reactome:REACT_83980 "citrate <=> isocitrate, Gallus gallus" xref: Reactome:REACT_86078 "citrate <=> isocitrate, Danio rerio" xref: Reactome:REACT_90644 "citrate <=> isocitrate, Drosophila melanogaster" xref: Reactome:REACT_97737 "citrate <=> isocitrate, Sus scrofa" xref: RHEA:10339 is_a: GO:0016836 ! hydro-lyase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004003 name: ATP-dependent DNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix." [EC:3.6.1.3, GOC:jl] subset: gosubset_prok is_a: GO:0003678 ! DNA helicase activity is_a: GO:0008026 ! ATP-dependent helicase activity is_a: GO:0008094 ! DNA-dependent ATPase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004016 name: adenylate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [EC:4.6.1.1] subset: gosubset_prok synonym: "3',5'-cyclic AMP synthetase activity" EXACT [EC:4.6.1.1] synonym: "adenyl cyclase activity" EXACT [EC:4.6.1.1] synonym: "adenylyl cyclase activity" EXACT [] synonym: "adenylylcyclase activity" EXACT [EC:4.6.1.1] synonym: "ATP diphosphate-lyase (cyclizing) activity" EXACT [EC:4.6.1.1] synonym: "ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity" EXACT [EC:4.6.1.1] synonym: "ATP pyrophosphate-lyase activity" EXACT [EC:4.6.1.1] synonym: "cAMP generating peptide activity" RELATED [] xref: EC:4.6.1.1 xref: MetaCyc:ADENYLATECYC-RXN xref: Reactome:REACT_101083 "Activated Adenylate cyclase catalyses cAMP synthesis, Gallus gallus" xref: Reactome:REACT_103498 "Production of Cyclic AMP by Activated Adenylyl Cyclase, Sus scrofa" xref: Reactome:REACT_104211 "Adenylate cyclase converts ATP into cyclic AMP, Drosophila melanogaster" xref: Reactome:REACT_106348 "Activated Adenylate cyclase catalyses cAMP synthesis, Taeniopygia guttata" xref: Reactome:REACT_110132 "Production of Cyclic AMP by Activated Adenylyl Cyclase, Bos taurus" xref: Reactome:REACT_110346 "Adenylate cyclase converts ATP into cyclic AMP, Caenorhabditis elegans" xref: Reactome:REACT_114273 "Production of Cyclic AMP by Activated Adenylyl Cyclase, Xenopus tropicalis" xref: Reactome:REACT_114694 "Production of Cyclic AMP by Activated Adenylyl Cyclase, Drosophila melanogaster" xref: Reactome:REACT_1292 "Activated Adenylate cyclase catalyses cAMP synthesis, Homo sapiens" xref: Reactome:REACT_15399 "Adenylate cyclase converts ATP into cyclic AMP, Homo sapiens" xref: Reactome:REACT_18321 "Production of Cyclic AMP by Activated Adenylyl Cyclase, Homo sapiens" xref: Reactome:REACT_19249 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Homo sapiens" xref: Reactome:REACT_19407 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Canis familiaris" xref: Reactome:REACT_20564 "Activation of Adenylate Cyclase, Homo sapiens" xref: Reactome:REACT_28885 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Bos taurus" xref: Reactome:REACT_28984 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Caenorhabditis elegans" xref: Reactome:REACT_30072 "Production of Cyclic AMP by Activated Adenylyl Cyclase, Danio rerio" xref: Reactome:REACT_30354 "Activated Adenylate cyclase catalyses cAMP synthesis, Caenorhabditis elegans" xref: Reactome:REACT_32296 "Adenylate cyclase converts ATP into cyclic AMP, Bos taurus" xref: Reactome:REACT_77589 "Activated Adenylate cyclase catalyses cAMP synthesis, Danio rerio" xref: Reactome:REACT_77648 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Danio rerio" xref: Reactome:REACT_77920 "Adenylate cyclase converts ATP into cyclic AMP, Canis familiaris" xref: Reactome:REACT_78464 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Taeniopygia guttata" xref: Reactome:REACT_78878 "Production of Cyclic AMP by Activated Adenylyl Cyclase, Taeniopygia guttata" xref: Reactome:REACT_79135 "Adenylate cyclase converts ATP into cyclic AMP, Mus musculus" xref: Reactome:REACT_79837 "Adenylate cyclase converts ATP into cyclic AMP, Taeniopygia guttata" xref: Reactome:REACT_80253 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Drosophila melanogaster" xref: Reactome:REACT_80404 "Activated Adenylate cyclase catalyses cAMP synthesis, Mus musculus" xref: Reactome:REACT_80465 "Activated Adenylate cyclase catalyses cAMP synthesis, Drosophila melanogaster" xref: Reactome:REACT_80777 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Rattus norvegicus" xref: Reactome:REACT_81089 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Sus scrofa" xref: Reactome:REACT_81527 "Production of Cyclic AMP by Activated Adenylyl Cyclase, Canis familiaris" xref: Reactome:REACT_81605 "Adenylate cyclase converts ATP into cyclic AMP, Rattus norvegicus" xref: Reactome:REACT_84068 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Mus musculus" xref: Reactome:REACT_84304 "Adenylate cyclase converts ATP into cyclic AMP, Gallus gallus" xref: Reactome:REACT_84639 "Activated Adenylate cyclase catalyses cAMP synthesis, Canis familiaris" xref: Reactome:REACT_85469 "Adenylate cyclase converts ATP into cyclic AMP, Xenopus tropicalis" xref: Reactome:REACT_85953 "Adenylate cyclase converts ATP into cyclic AMP, Danio rerio" xref: Reactome:REACT_86733 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Xenopus tropicalis" xref: Reactome:REACT_87138 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Gallus gallus" xref: Reactome:REACT_92664 "Production of Cyclic AMP by Activated Adenylyl Cyclase, Mus musculus" xref: Reactome:REACT_92794 "Activated Adenylate cyclase catalyses cAMP synthesis, Sus scrofa" xref: Reactome:REACT_93757 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate, Mycobacterium tuberculosis" xref: Reactome:REACT_94136 "Activated Adenylate cyclase catalyses cAMP synthesis, Xenopus tropicalis" xref: Reactome:REACT_97516 "Activated Adenylate cyclase catalyses cAMP synthesis, Bos taurus" xref: RHEA:15392 is_a: GO:0009975 ! cyclase activity is_a: GO:0016849 ! phosphorus-oxygen lyase activity relationship: part_of GO:0006171 ! cAMP biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004017 name: adenylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3] subset: gosubset_prok synonym: "5'-AMP-kinase activity" EXACT [EC:2.7.4.3] synonym: "adenylic kinase activity" EXACT [EC:2.7.4.3] synonym: "adenylokinase activity" EXACT [EC:2.7.4.3] synonym: "ATP:AMP phosphotransferase activity" EXACT [EC:2.7.4.3] synonym: "myokinase activity" NARROW [EC:2.7.4.3] xref: EC:2.7.4.3 xref: MetaCyc:ADENYL-KIN-RXN xref: Reactome:REACT_100300 "AMP + ATP <=> ADP + ADP [AK2], Schizosaccharomyces pombe" xref: Reactome:REACT_100354 "ADP + ADP <=> AMP + ATP [AK2], Dictyostelium discoideum" xref: Reactome:REACT_100509 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Drosophila melanogaster" xref: Reactome:REACT_100999 "ADP + ADP <=> AMP + ATP [AK2], Canis familiaris" xref: Reactome:REACT_101925 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Canis familiaris" xref: Reactome:REACT_101986 "ADP + ADP <=> AMP + ATP [AK2], Mus musculus" xref: Reactome:REACT_102985 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Sus scrofa" xref: Reactome:REACT_103652 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Mus musculus" xref: Reactome:REACT_104314 "ADP + ADP <=> AMP + ATP [AK2], Rattus norvegicus" xref: Reactome:REACT_106139 "ADP + ADP <=> AMP + ATP [AK2], Saccharomyces cerevisiae" xref: Reactome:REACT_107217 "ADP + ADP <=> AMP + ATP [AK2], Taeniopygia guttata" xref: Reactome:REACT_109890 "ADP + ADP <=> AMP + ATP [AK2], Oryza sativa" xref: Reactome:REACT_110965 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Drosophila melanogaster" xref: Reactome:REACT_114340 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Escherichia coli" xref: Reactome:REACT_114949 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Escherichia coli" xref: Reactome:REACT_2031 "ADP + ADP <=> AMP + ATP [AK2], Homo sapiens" xref: Reactome:REACT_29050 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Danio rerio" xref: Reactome:REACT_29136 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Caenorhabditis elegans" xref: Reactome:REACT_31416 "AMP + ATP <=> ADP + ADP [AK2], Bos taurus" xref: Reactome:REACT_31539 "ADP + ADP <=> AMP + ATP [AK2], Danio rerio" xref: Reactome:REACT_32379 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Taeniopygia guttata" xref: Reactome:REACT_32517 "AMP + ATP <=> ADP + ADP [AK2], Drosophila melanogaster" xref: Reactome:REACT_33002 "AMP + ATP <=> ADP + ADP [AK2], Rattus norvegicus" xref: Reactome:REACT_33987 "AMP + ATP <=> ADP + ADP [AK2], Danio rerio" xref: Reactome:REACT_34796 "ADP + ADP <=> AMP + ATP [AK2], Bos taurus" xref: Reactome:REACT_390 "AMP + ATP <=> ADP + ADP [AK2], Homo sapiens" xref: Reactome:REACT_643 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Homo sapiens" xref: Reactome:REACT_763 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Homo sapiens" xref: Reactome:REACT_78886 "AMP + ATP <=> ADP + ADP [AK2], Gallus gallus" xref: Reactome:REACT_78917 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Danio rerio" xref: Reactome:REACT_79891 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Mus musculus" xref: Reactome:REACT_80849 "AMP + ATP <=> ADP + ADP [AK2], Saccharomyces cerevisiae" xref: Reactome:REACT_80989 "AMP + ATP <=> ADP + ADP [AK2], Dictyostelium discoideum" xref: Reactome:REACT_82847 "AMP + ATP <=> ADP + ADP [AK2], Mus musculus" xref: Reactome:REACT_84010 "AMP + ATP <=> ADP + ADP [AK2], Arabidopsis thaliana" xref: Reactome:REACT_84704 "ADP + ADP <=> AMP + ATP [AK2], Xenopus tropicalis" xref: Reactome:REACT_85367 "ADP + ADP <=> AMP + ATP [AK2], Drosophila melanogaster" xref: Reactome:REACT_85846 "ADP + ADP <=> AMP + ATP [AK2], Gallus gallus" xref: Reactome:REACT_87077 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Caenorhabditis elegans" xref: Reactome:REACT_87621 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Canis familiaris" xref: Reactome:REACT_88917 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Bos taurus" xref: Reactome:REACT_88924 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Taeniopygia guttata" xref: Reactome:REACT_90905 "AMP + ATP <=> ADP + ADP [AK2], Escherichia coli" xref: Reactome:REACT_91426 "ADP + ADP <=> AMP + ATP [AK2], Caenorhabditis elegans" xref: Reactome:REACT_91927 "AMP + ATP <=> ADP + ADP [AK2], Oryza sativa" xref: Reactome:REACT_92343 "ADP + ADP <=> AMP + ATP [AK2], Arabidopsis thaliana" xref: Reactome:REACT_92843 "ADP + ADP <=> AMP + ATP [AK2], Schizosaccharomyces pombe" xref: Reactome:REACT_92937 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Xenopus tropicalis" xref: Reactome:REACT_93851 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Xenopus tropicalis" xref: Reactome:REACT_94373 "AMP + ATP <=> ADP + ADP [AK2], Canis familiaris" xref: Reactome:REACT_95537 "AMP + ATP <=> ADP + ADP [AK2], Taeniopygia guttata" xref: Reactome:REACT_96203 "AMP + ATP <=> ADP + ADP [AK2], Xenopus tropicalis" xref: Reactome:REACT_96441 "(d)AMP + ATP <=> (d)ADP + ADP [AK1], Bos taurus" xref: Reactome:REACT_97658 "AMP + ATP <=> ADP + ADP [AK2], Caenorhabditis elegans" xref: Reactome:REACT_98806 "ADP + ADP <=> AMP + ATP [AK2], Escherichia coli" xref: Reactome:REACT_99365 "(d)ADP + ADP <=> (d)AMP + ATP [AK1], Sus scrofa" xref: RHEA:12976 is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor is_a: GO:0019201 ! nucleotide kinase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004022 name: alcohol dehydrogenase (NAD) activity namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [EC:1.1.1.1] subset: gosubset_prok synonym: "ADH" RELATED [EC:1.1.1.1] synonym: "alcohol dehydrogenase activity" BROAD [GOC:mah] synonym: "alcohol:NAD+ oxidoreductase" EXACT [EC:1.1.1.1] synonym: "aldehyde dehydrogenase (NAD) activity" NARROW [] synonym: "aldo-keto reductase (NAD) activity" EXACT [] synonym: "aliphatic alcohol dehydrogenase" NARROW [EC:1.1.1.1] synonym: "ethanol dehydrogenase" NARROW [EC:1.1.1.1] synonym: "NAD-dependent alcohol dehydrogenase" EXACT [EC:1.1.1.1] synonym: "NAD-specific aromatic alcohol dehydrogenase" EXACT [EC:1.1.1.1] synonym: "NADH-alcohol dehydrogenase" EXACT [EC:1.1.1.1] synonym: "NADH-aldehyde dehydrogenase" EXACT [EC:1.1.1.1] synonym: "primary alcohol dehydrogenase" BROAD [EC:1.1.1.1] synonym: "yeast alcohol dehydrogenase" NARROW [EC:1.1.1.1] xref: EC:1.1.1.1 xref: MetaCyc:ALCOHOL-DEHYDROG-GENERIC-RXN xref: UM-BBD_enzymeID:e0023 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004033 name: aldo-keto reductase (NADP) activity namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+." [GOC:ai] subset: gosubset_prok synonym: "alcohol dehydrogenase (NADP+) activity" NARROW [] synonym: "aldo-keto reductase (NADP+) activity" EXACT [] synonym: "aldo-keto reductase activity" EXACT [] synonym: "NADPH-dependent aldo-keto reductase activity" EXACT [GOC:vw] xref: EC:1.1.1.- xref: Reactome:REACT_10008 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol, Homo sapiens" xref: Reactome:REACT_10018 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Homo sapiens" xref: Reactome:REACT_10038 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol, Homo sapiens" xref: Reactome:REACT_10044 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol, Homo sapiens" xref: Reactome:REACT_100460 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Canis familiaris" xref: Reactome:REACT_10048 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Homo sapiens" xref: Reactome:REACT_10054 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol, Homo sapiens" xref: Reactome:REACT_10068 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol, Homo sapiens" xref: Reactome:REACT_10086 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Homo sapiens" xref: Reactome:REACT_10102 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Homo sapiens" xref: Reactome:REACT_10120 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol, Homo sapiens" xref: Reactome:REACT_10131 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Homo sapiens" xref: Reactome:REACT_101534 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Bos taurus" xref: Reactome:REACT_101629 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Rattus norvegicus" xref: Reactome:REACT_101931 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Mus musculus" xref: Reactome:REACT_104573 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol, Mus musculus" xref: Reactome:REACT_104664 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Xenopus tropicalis" xref: Reactome:REACT_104786 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Mus musculus" xref: Reactome:REACT_105193 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Rattus norvegicus" xref: Reactome:REACT_106036 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol, Xenopus tropicalis" xref: Reactome:REACT_106194 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Mus musculus" xref: Reactome:REACT_106928 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Taeniopygia guttata" xref: Reactome:REACT_108439 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol, Mus musculus" xref: Reactome:REACT_108757 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Saccharomyces cerevisiae" xref: Reactome:REACT_110383 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Xenopus tropicalis" xref: Reactome:REACT_110687 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol, Mus musculus" xref: Reactome:REACT_110920 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Canis familiaris" xref: Reactome:REACT_11100 "Reduction of semidehydroascorbate to ascorbate, Homo sapiens" xref: Reactome:REACT_111993 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Dictyostelium discoideum" xref: Reactome:REACT_112004 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Dictyostelium discoideum" xref: Reactome:REACT_112078 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol, Drosophila melanogaster" xref: Reactome:REACT_112094 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Dictyostelium discoideum" xref: Reactome:REACT_112136 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Drosophila melanogaster" xref: Reactome:REACT_112164 "Reduction of semidehydroascorbate to ascorbate, Dictyostelium discoideum" xref: Reactome:REACT_112352 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol, Dictyostelium discoideum" xref: Reactome:REACT_112380 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Oryza sativa" xref: Reactome:REACT_112446 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol, Arabidopsis thaliana" xref: Reactome:REACT_112477 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol, Drosophila melanogaster" xref: Reactome:REACT_112538 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Oryza sativa" xref: Reactome:REACT_112546 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol, Arabidopsis thaliana" xref: Reactome:REACT_112547 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol, Arabidopsis thaliana" xref: Reactome:REACT_112635 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol, Dictyostelium discoideum" xref: Reactome:REACT_112765 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol, Oryza sativa" xref: Reactome:REACT_112786 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol, Drosophila melanogaster" xref: Reactome:REACT_112971 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol, Drosophila melanogaster" xref: Reactome:REACT_113067 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol, Dictyostelium discoideum" xref: Reactome:REACT_113108 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Dictyostelium discoideum" xref: Reactome:REACT_113453 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Oryza sativa" xref: Reactome:REACT_113482 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Drosophila melanogaster" xref: Reactome:REACT_113545 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Drosophila melanogaster" xref: Reactome:REACT_113590 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Arabidopsis thaliana" xref: Reactome:REACT_113657 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol, Arabidopsis thaliana" xref: Reactome:REACT_113694 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Drosophila melanogaster" xref: Reactome:REACT_113742 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol, Dictyostelium discoideum" xref: Reactome:REACT_113762 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol, Oryza sativa" xref: Reactome:REACT_113791 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Arabidopsis thaliana" xref: Reactome:REACT_113879 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Oryza sativa" xref: Reactome:REACT_113982 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol, Arabidopsis thaliana" xref: Reactome:REACT_114182 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Drosophila melanogaster" xref: Reactome:REACT_114303 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol, Arabidopsis thaliana" xref: Reactome:REACT_114413 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol, Oryza sativa" xref: Reactome:REACT_114451 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol, Oryza sativa" xref: Reactome:REACT_114529 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol, Drosophila melanogaster" xref: Reactome:REACT_114561 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol, Oryza sativa" xref: Reactome:REACT_114574 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol, Dictyostelium discoideum" xref: Reactome:REACT_114601 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Dictyostelium discoideum" xref: Reactome:REACT_114670 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Arabidopsis thaliana" xref: Reactome:REACT_114682 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Oryza sativa" xref: Reactome:REACT_114688 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol, Drosophila melanogaster" xref: Reactome:REACT_114788 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Oryza sativa" xref: Reactome:REACT_114934 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol, Oryza sativa" xref: Reactome:REACT_114943 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Dictyostelium discoideum" xref: Reactome:REACT_114951 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol, Dictyostelium discoideum" xref: Reactome:REACT_115178 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Drosophila melanogaster" xref: Reactome:REACT_115352 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Arabidopsis thaliana" xref: Reactome:REACT_115369 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Arabidopsis thaliana" xref: Reactome:REACT_115407 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Arabidopsis thaliana" xref: Reactome:REACT_28191 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol, Saccharomyces cerevisiae" xref: Reactome:REACT_28575 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol, Saccharomyces cerevisiae" xref: Reactome:REACT_28637 "Reduction of semidehydroascorbate to ascorbate, Caenorhabditis elegans" xref: Reactome:REACT_28655 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Saccharomyces cerevisiae" xref: Reactome:REACT_28677 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Xenopus tropicalis" xref: Reactome:REACT_28850 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Canis familiaris" xref: Reactome:REACT_28933 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol, Xenopus tropicalis" xref: Reactome:REACT_29682 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Mus musculus" xref: Reactome:REACT_30872 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Gallus gallus" xref: Reactome:REACT_31905 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Saccharomyces cerevisiae" xref: Reactome:REACT_31910 "Reduction of semidehydroascorbate to ascorbate, Canis familiaris" xref: Reactome:REACT_32080 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Gallus gallus" xref: Reactome:REACT_32937 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Canis familiaris" xref: Reactome:REACT_33063 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Bos taurus" xref: Reactome:REACT_33464 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Rattus norvegicus" xref: Reactome:REACT_77287 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Mus musculus" xref: Reactome:REACT_79323 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Saccharomyces cerevisiae" xref: Reactome:REACT_79627 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Mus musculus" xref: Reactome:REACT_79990 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol, Xenopus tropicalis" xref: Reactome:REACT_81316 "Reduction of semidehydroascorbate to ascorbate, Sus scrofa" xref: Reactome:REACT_82437 "Reduction of semidehydroascorbate to ascorbate, Danio rerio" xref: Reactome:REACT_82926 "Reduction of semidehydroascorbate to ascorbate, Mus musculus" xref: Reactome:REACT_82973 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Bos taurus" xref: Reactome:REACT_82990 "Reduction of semidehydroascorbate to ascorbate, Taeniopygia guttata" xref: Reactome:REACT_83001 "Reduction of semidehydroascorbate to ascorbate, Gallus gallus" xref: Reactome:REACT_83433 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Saccharomyces cerevisiae" xref: Reactome:REACT_83731 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Canis familiaris" xref: Reactome:REACT_84395 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Rattus norvegicus" xref: Reactome:REACT_84566 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Taeniopygia guttata" xref: Reactome:REACT_84799 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Bos taurus" xref: Reactome:REACT_85106 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Taeniopygia guttata" xref: Reactome:REACT_85206 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Taeniopygia guttata" xref: Reactome:REACT_85231 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol, Saccharomyces cerevisiae" xref: Reactome:REACT_85587 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol, Saccharomyces cerevisiae" xref: Reactome:REACT_85900 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Saccharomyces cerevisiae" xref: Reactome:REACT_86109 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Taeniopygia guttata" xref: Reactome:REACT_86399 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Rattus norvegicus" xref: Reactome:REACT_87189 "Reduction of semidehydroascorbate to ascorbate, Bos taurus" xref: Reactome:REACT_87397 "Reduction of semidehydroascorbate to ascorbate, Drosophila melanogaster" xref: Reactome:REACT_87734 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol, Saccharomyces cerevisiae" xref: Reactome:REACT_89410 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Xenopus tropicalis" xref: Reactome:REACT_90460 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol, Xenopus tropicalis" xref: Reactome:REACT_91267 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Bos taurus" xref: Reactome:REACT_91578 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Taeniopygia guttata" xref: Reactome:REACT_92005 "Reduction of semidehydroascorbate to ascorbate, Rattus norvegicus" xref: Reactome:REACT_92354 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol, Mus musculus" xref: Reactome:REACT_92749 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Gallus gallus" xref: Reactome:REACT_92830 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Bos taurus" xref: Reactome:REACT_93550 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol, Mus musculus" xref: Reactome:REACT_93907 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Canis familiaris" xref: Reactome:REACT_94094 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one, Xenopus tropicalis" xref: Reactome:REACT_94919 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one, Xenopus tropicalis" xref: Reactome:REACT_95441 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol, Mus musculus" xref: Reactome:REACT_95886 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol, Saccharomyces cerevisiae" xref: Reactome:REACT_96852 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one, Rattus norvegicus" xref: Reactome:REACT_97815 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol, Xenopus tropicalis" xref: Reactome:REACT_98175 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol, Xenopus tropicalis" xref: Reactome:REACT_98269 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one, Gallus gallus" xref: Reactome:REACT_98473 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one, Gallus gallus" xref: Reactome:REACT_98695 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Gallus gallus" xref: Reactome:REACT_99599 "Reduction of semidehydroascorbate to ascorbate, Xenopus tropicalis" xref: Reactome:REACT_9972 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one, Homo sapiens" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004043 name: L-aminoadipate-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+." [EC:1.2.1.31] subset: gosubset_prok synonym: "2-aminoadipate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "2-aminoadipic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "AAR" EXACT [EC:1.2.1.31] synonym: "alpha-aminoadipate reductase activity" EXACT [EC:1.2.1.31] synonym: "alpha-aminoadipate-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "aminoadipate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "aminoadipate-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase" EXACT [EC:1.2.1.31] synonym: "L-alpha-aminoadipate delta-semialdehyde oxidoreductase activity" EXACT [EC:1.2.1.31] synonym: "L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase activity" EXACT [EC:1.2.1.31] synonym: "L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase activity" EXACT [EC:1.2.1.31] xref: EC:1.2.1.31 xref: MetaCyc:1.2.1.31-RXN xref: Reactome:REACT_110440 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Arabidopsis thaliana" xref: Reactome:REACT_1540 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Homo sapiens" xref: Reactome:REACT_34232 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Danio rerio" xref: Reactome:REACT_34396 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Mycobacterium tuberculosis" xref: Reactome:REACT_77435 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Oryza sativa" xref: Reactome:REACT_79544 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Dictyostelium discoideum" xref: Reactome:REACT_80215 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Caenorhabditis elegans" xref: Reactome:REACT_80324 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Canis familiaris" xref: Reactome:REACT_81404 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Gallus gallus" xref: Reactome:REACT_84541 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Sus scrofa" xref: Reactome:REACT_86291 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Drosophila melanogaster" xref: Reactome:REACT_88752 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Taeniopygia guttata" xref: Reactome:REACT_92070 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Rattus norvegicus" xref: Reactome:REACT_92791 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Bos taurus" xref: Reactome:REACT_95793 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Xenopus tropicalis" xref: Reactome:REACT_97958 "alpha-aminoadipic semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+, Mus musculus" is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004081 name: bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity namespace: molecular_function def: "Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate." [EC:3.6.1.17, PMID:4955726] subset: gosubset_prok synonym: "1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.17] synonym: "Ap(4)A hydrolase activity" BROAD [EC:3.6.1.17] synonym: "Ap(4)Aase activity" BROAD [EC:3.6.1.17] synonym: "Ap4A hydrolase activity" BROAD [EC:3.6.1.17] synonym: "Ap4Aase activity" BROAD [EC:3.6.1.17] synonym: "bis(5'-adenosyl)-tetraphosphatase activity" NARROW [EC:3.6.1.17] synonym: "bis(5'-guanosyl)-tetraphosphatase activity" NARROW [EC:3.6.1.17] synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate asymmetrical hydrolase activity" EXACT [EC:3.6.1.17] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase activity" EXACT [EC:3.6.1.17] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase" NARROW [] synonym: "diadenosine P1,P4-tetraphosphatase activity" EXACT [EC:3.6.1.17] synonym: "diadenosinetetraphosphatase (asymmetrical) activity" NARROW [EC:3.6.1.17] synonym: "diguanosinetetraphosphatase (asymmetrical) activity" NARROW [EC:3.6.1.17] synonym: "dinucleoside tetraphosphatase activity" EXACT [EC:3.6.1.17] synonym: "dinucleosidetetraphosphatase (asymmetrical) activity" EXACT [EC:3.6.1.17] synonym: "P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.17] xref: EC:3.6.1.17 xref: MetaCyc:3.6.1.17-RXN xref: RHEA:22487 is_a: GO:0008796 ! bis(5'-nucleosyl)-tetraphosphatase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004096 name: catalase activity namespace: molecular_function alt_id: GO:0016952 alt_id: GO:0016953 def: "Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O." [EC:1.11.1.6] subset: gosubset_prok synonym: "bacterial catalase-peroxidase activity" NARROW [] synonym: "caperase activity" EXACT [EC:1.11.1.6] synonym: "CAT" RELATED [EC:1.11.1.6] synonym: "catalase reaction" EXACT [] synonym: "catalase-peroxidase activity" EXACT [EC:1.11.1.6] synonym: "equilase activity" EXACT [EC:1.11.1.6] synonym: "haem catalase activity" NARROW [] synonym: "heme catalase activity" NARROW [] synonym: "hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.6] synonym: "manganese catalase activity" NARROW [] synonym: "optidase activity" EXACT [EC:1.11.1.6] xref: EC:1.11.1.6 xref: MetaCyc:CATAL-RXN xref: Reactome:REACT_101648 "2 H2O2 => O2 + 2 H2O, Gallus gallus" xref: Reactome:REACT_108235 "2 H2O2 => O2 + 2 H2O, Saccharomyces cerevisiae" xref: Reactome:REACT_112160 "2 H2O2 => O2 + 2 H2O, Caenorhabditis elegans" xref: Reactome:REACT_30681 "2 H2O2 => O2 + 2 H2O, Escherichia coli" xref: Reactome:REACT_30704 "2 H2O2 => O2 + 2 H2O, Drosophila melanogaster" xref: Reactome:REACT_30957 "2 H2O2 => O2 + 2 H2O, Mus musculus" xref: Reactome:REACT_615 "2 H2O2 => O2 + 2 H2O, Homo sapiens" xref: Reactome:REACT_79013 "2 H2O2 => O2 + 2 H2O, Taeniopygia guttata" xref: Reactome:REACT_79757 "2 H2O2 => O2 + 2 H2O, Schizosaccharomyces pombe" xref: Reactome:REACT_85074 "2 H2O2 => O2 + 2 H2O, Staphylococcus aureus N315" xref: Reactome:REACT_85170 "2 H2O2 => O2 + 2 H2O, Bos taurus" xref: Reactome:REACT_87638 "2 H2O2 => O2 + 2 H2O, Dictyostelium discoideum" xref: Reactome:REACT_89864 "2 H2O2 => O2 + 2 H2O, Sus scrofa" xref: Reactome:REACT_90743 "2 H2O2 => O2 + 2 H2O, Rattus norvegicus" xref: Reactome:REACT_91037 "2 H2O2 => O2 + 2 H2O, Danio rerio" xref: Reactome:REACT_91307 "2 H2O2 => O2 + 2 H2O, Canis familiaris" xref: Reactome:REACT_96832 "2 H2O2 => O2 + 2 H2O, Xenopus tropicalis" xref: RHEA:20312 xref: UM-BBD_enzymeID:e0834 is_a: GO:0004601 ! peroxidase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004108 name: citrate (Si)-synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group." [EC:2.3.3.1, ISBN:0121227073] comment: Note that this function was formerly EC:4.1.3.7. subset: gosubset_prok synonym: "(R)-citric synthase activity" EXACT [EC:2.3.3.1] synonym: "acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming]" RELATED [EC:2.3.3.1] synonym: "citrate condensing enzyme activity" EXACT [EC:2.3.3.1] synonym: "citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity" EXACT [EC:2.3.3.1] synonym: "citrate oxaloacetate-lyase ((pro-3S)-CH2COO-rightacetyl-CoA)" EXACT [EC:2.3.3.1] synonym: "citrate oxaloacetate-lyase [(pro-3S)-CH2COOrightacetyl-CoA]" RELATED [EC:2.3.3.1] synonym: "citrate oxaloacetate-lyase, CoA-acetylating activity" EXACT [EC:2.3.3.1] synonym: "citrate synthase activity" BROAD [EC:2.3.3.1] synonym: "citrate synthetase activity" EXACT [EC:2.3.3.1] synonym: "citric synthase activity" EXACT [EC:2.3.3.1] synonym: "citric-condensing enzyme activity" EXACT [EC:2.3.3.1] synonym: "citrogenase activity" EXACT [EC:2.3.3.1] synonym: "condensing enzyme activity" BROAD [EC:2.3.3.1] synonym: "oxalacetic transacetase activity" EXACT [EC:2.3.3.1] synonym: "oxaloacetate transacetase activity" EXACT [EC:2.3.3.1] xref: EC:2.3.3.1 xref: MetaCyc:CITSYN-RXN xref: Reactome:REACT_100557 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Mus musculus" xref: Reactome:REACT_100736 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Staphylococcus aureus N315" xref: Reactome:REACT_103631 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Xenopus tropicalis" xref: Reactome:REACT_107569 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Rattus norvegicus" xref: Reactome:REACT_108814 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Bos taurus" xref: Reactome:REACT_115605 "acetyl-CoA + H2O + oxaloacetate => citrate + CoA, Gallus gallus" xref: Reactome:REACT_1282 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Homo sapiens" xref: Reactome:REACT_32191 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Drosophila melanogaster" xref: Reactome:REACT_33399 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Danio rerio" xref: Reactome:REACT_81174 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Dictyostelium discoideum" xref: Reactome:REACT_81802 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Plasmodium falciparum" xref: Reactome:REACT_83386 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Oryza sativa" xref: Reactome:REACT_87177 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Arabidopsis thaliana" xref: Reactome:REACT_88391 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Caenorhabditis elegans" xref: Reactome:REACT_91540 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Canis familiaris" xref: Reactome:REACT_94285 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Schizosaccharomyces pombe" xref: Reactome:REACT_96879 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA, Sus scrofa" is_a: GO:0036440 ! citrate synthase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004124 name: cysteine synthase activity namespace: molecular_function def: "Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate." [EC:4.2.99.8] comment: Note that this function was formerly 4.2.99.8. subset: gosubset_prok synonym: "3-O-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.47] synonym: "acetylserine sulfhydrylase activity" EXACT [EC:2.5.1.47] synonym: "cysteine synthetase activity" EXACT [EC:2.5.1.47] synonym: "O(3)-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide) activity" EXACT [EC:2.5.1.47] synonym: "O-acetyl-L-serine sulfhydrylase activity" EXACT [EC:2.5.1.47] synonym: "O-acetyl-L-serine sulfohydrolase activity" EXACT [EC:2.5.1.47] synonym: "O-acetylserine (thiol)-lyase A activity" NARROW [EC:2.5.1.47] synonym: "O-acetylserine (thiol)-lyase activity" EXACT [EC:2.5.1.47] synonym: "O-acetylserine sulfhydrylase activity" EXACT [EC:2.5.1.47] synonym: "O3-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide)" EXACT [EC:2.5.1.47] synonym: "O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.47] synonym: "OAS sulfhydrylase activity" EXACT [EC:2.5.1.47] xref: EC:2.5.1.47 xref: MetaCyc:ACSERLY-RXN xref: Reactome:REACT_27172 "deacetylation of O-acetylserine and sulfhydrylation using CysK2, Mycobacterium tuberculosis" xref: Reactome:REACT_27282 "deacetylation of O-acetylserine and sulfhydrylation using CysK1, Mycobacterium tuberculosis" xref: RHEA:14832 is_a: GO:0016835 ! carbon-oxygen lyase activity relationship: part_of GO:0019344 ! cysteine biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004129 name: cytochrome-c oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] comment: The reduction of O2 to water is accompanied by the extrusion of four protons from the intramitochondrial compartment. subset: gosubset_prok synonym: "aa3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "ba3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "caa3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "cbb3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "complex IV (mitochondrial electron transport) activity" RELATED [EC:1.9.3.1] synonym: "cytochrome a3 activity" NARROW [EC:1.9.3.1] synonym: "cytochrome aa3 activity" NARROW [EC:1.9.3.1] synonym: "cytochrome c oxidase activity" EXACT [GOC:tb] synonym: "cytochrome oxidase activity" RELATED [EC:1.9.3.1] synonym: "ferrocytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "ferrocytochrome-c:oxygen oxidoreductase" NARROW [EC:1.9.3.1] synonym: "indophenol oxidase" NARROW [EC:1.9.3.1] synonym: "indophenolase" NARROW [EC:1.9.3.1] synonym: "NADH cytochrome c oxidase" EXACT [EC:1.9.3.1] synonym: "warburg's respiratory enzyme activity" RELATED [EC:1.9.3.1] xref: EC:1.9.3.1 xref: MetaCyc:CYTOCHROME-C-OXIDASE-RXN xref: Reactome:REACT_113276 "Electron transfer from reduced cytochrome c to molecular oxygen, Bos taurus" xref: Reactome:REACT_113311 "Electron transfer from reduced cytochrome c to molecular oxygen, Sus scrofa" xref: Reactome:REACT_113736 "Electron transfer from reduced cytochrome c to molecular oxygen, Canis familiaris" xref: Reactome:REACT_115027 "Electron transfer from reduced cytochrome c to molecular oxygen, Rattus norvegicus" xref: Reactome:REACT_33608 "Electron transfer from reduced cytochrome c to molecular oxygen, Danio rerio" xref: Reactome:REACT_6149 "Electron transfer from reduced cytochrome c to molecular oxygen, Homo sapiens" xref: Reactome:REACT_78871 "Electron transfer from reduced cytochrome c to molecular oxygen, Gallus gallus" xref: Reactome:REACT_99789 "Electron transfer from reduced cytochrome c to molecular oxygen, Mus musculus" is_a: GO:0009055 ! electron carrier activity is_a: GO:0015002 ! heme-copper terminal oxidase activity is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity is_a: GO:0016676 ! oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004144 name: diacylglycerol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol." [EC:2.3.1.20] subset: gosubset_prok synonym: "1,2-diacylglycerol acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "acyl-CoA:1,2-diacylglycerol O-acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "diacylglycerol acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "diglyceride acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "diglyceride O-acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase activity" EXACT [EC:2.3.1.20] xref: EC:2.3.1.20 xref: MetaCyc:DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN xref: Reactome:REACT_100155 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Rattus norvegicus" xref: Reactome:REACT_103886 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Taeniopygia guttata" xref: Reactome:REACT_104139 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Sus scrofa" xref: Reactome:REACT_104875 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Mus musculus" xref: Reactome:REACT_110678 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Xenopus tropicalis" xref: Reactome:REACT_112540 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Arabidopsis thaliana" xref: Reactome:REACT_112715 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Schizosaccharomyces pombe" xref: Reactome:REACT_114635 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Oryza sativa" xref: Reactome:REACT_22179 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Homo sapiens" xref: Reactome:REACT_28123 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Plasmodium falciparum" xref: Reactome:REACT_28392 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Sus scrofa" xref: Reactome:REACT_31769 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Rattus norvegicus" xref: Reactome:REACT_32550 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Drosophila melanogaster" xref: Reactome:REACT_659 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Homo sapiens" xref: Reactome:REACT_77149 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Oryza sativa" xref: Reactome:REACT_77431 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Canis familiaris" xref: Reactome:REACT_81790 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Bos taurus" xref: Reactome:REACT_88501 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Caenorhabditis elegans" xref: Reactome:REACT_89294 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Danio rerio" xref: Reactome:REACT_89429 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Canis familiaris" xref: Reactome:REACT_92156 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Dictyostelium discoideum" xref: Reactome:REACT_92925 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Gallus gallus" xref: Reactome:REACT_93842 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Xenopus tropicalis" xref: Reactome:REACT_95845 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Bos taurus" xref: Reactome:REACT_96341 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Mus musculus" xref: Reactome:REACT_98065 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Arabidopsis thaliana" xref: Reactome:REACT_98763 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Saccharomyces cerevisiae" xref: Reactome:REACT_99469 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2], Danio rerio" xref: Reactome:REACT_99733 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1], Dictyostelium discoideum" xref: RHEA:10871 is_a: GO:0016411 ! acylglycerol O-acyltransferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004175 name: endopeptidase activity namespace: molecular_function alt_id: GO:0016809 def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] subset: gosubset_prok synonym: "elastase activity" RELATED [GOC:krc] synonym: "endoprotease activity" EXACT [] synonym: "proteasome endopeptidase activity" NARROW [] synonym: "proteinase" BROAD [] xref: Reactome:REACT_10017 "Degradation of ubiquitinated -beta catenin by the proteasome, Homo sapiens" xref: Reactome:REACT_101348 "Degradation of multiubiquitinated Cdh1, Rattus norvegicus" xref: Reactome:REACT_101866 "Ubiquitinated Cdc6 is degraded by the proteasome, Canis familiaris" xref: Reactome:REACT_101873 "Degradation of multiubiquitinated cell cycle proteins, Mus musculus" xref: Reactome:REACT_102952 "Degradation of multiubiquitinated Cdh1, Bos taurus" xref: Reactome:REACT_103814 "Degradation multiubiquitinated Cyclin A, Xenopus tropicalis" xref: Reactome:REACT_104331 "Ubiquitinated geminin is degraded by the proteasome, Mus musculus" xref: Reactome:REACT_104435 "Proteasome mediated degradation of Cyclin D1, Rattus norvegicus" xref: Reactome:REACT_104684 "Degradation of multiubiquitinated Cdh1, Danio rerio" xref: Reactome:REACT_104793 "Ubiquitinated Cdc6 is degraded by the proteasome, Mus musculus" xref: Reactome:REACT_105135 "Degradation of ubiquitinated -beta catenin by the proteasome, Canis familiaris" xref: Reactome:REACT_105245 "Ubiquitinated Orc1 is degraded by the proteasome, Danio rerio" xref: Reactome:REACT_105748 "APC/C:Cdh1-mediated degradation of Skp2, Canis familiaris" xref: Reactome:REACT_106234 "Ubiquitinated Orc1 is degraded by the proteasome, Mus musculus" xref: Reactome:REACT_106385 "Proteasome mediated degradation of COP1, Xenopus tropicalis" xref: Reactome:REACT_106617 "gamma-secretase cleaves the p75NTR transmembrane domain, Bos taurus" xref: Reactome:REACT_106687 "SCF-mediated degradation of Emi1, Bos taurus" xref: Reactome:REACT_107139 "Ubiquitinated geminin is degraded by the proteasome, Canis familiaris" xref: Reactome:REACT_107146 "Ubiquitinated Orc1 is degraded by the proteasome, Bos taurus" xref: Reactome:REACT_108185 "Ubiquitinated Orc1 is degraded by the proteasome, Oryza sativa" xref: Reactome:REACT_108448 "Proteasome mediated degradation of PAK-2p34, Mus musculus" xref: Reactome:REACT_108642 "Ubiquitinated geminin is degraded by the proteasome, Xenopus tropicalis" xref: Reactome:REACT_109047 "Degradation of multiubiquitinated Cdh1, Oryza sativa" xref: Reactome:REACT_109186 "Ubiquitinated Cdc6 is degraded by the proteasome, Danio rerio" xref: Reactome:REACT_109261 "Degradation of multiubiquitinated cell cycle proteins, Oryza sativa" xref: Reactome:REACT_110165 "Degradation of ubiquitinated p27/p21 by the 26S proteasome, Danio rerio" xref: Reactome:REACT_110191 "26S proteosome degrades ODC holoenzyme complex, Canis familiaris" xref: Reactome:REACT_110448 "Proteolytic degradation of ubiquitinated-Cdc25A, Xenopus tropicalis" xref: Reactome:REACT_110469 "gamma-secretase cleaves the p75NTR transmembrane domain, Rattus norvegicus" xref: Reactome:REACT_110487 "Proteolytic degradation of ubiquitinated-Cdc25A, Danio rerio" xref: Reactome:REACT_110752 "gamma-secretase cleaves the p75NTR transmembrane domain, Canis familiaris" xref: Reactome:REACT_111098 "Processing of SCF isoform 1, Homo sapiens" xref: Reactome:REACT_111104 "Proteasomal cleavage of substrate, Homo sapiens" xref: Reactome:REACT_111172 "Proteasomal clevage of exogenous antigen, Homo sapiens" xref: Reactome:REACT_112076 "Ubiquitinated Cdc6 is degraded by the proteasome, Sus scrofa" xref: Reactome:REACT_113623 "Ubiquitinated geminin is degraded by the proteasome, Sus scrofa" xref: Reactome:REACT_113749 "Ubiquitinated Orc1 is degraded by the proteasome, Sus scrofa" xref: Reactome:REACT_114002 "Proteasome mediated degradation of PAK-2p34, Sus scrofa" xref: Reactome:REACT_114449 "Proteasome mediated degradation of Cyclin D1, Sus scrofa" xref: Reactome:REACT_114993 "Proteasome mediated degradation of COP1, Sus scrofa" xref: Reactome:REACT_115363 "Proteasome mediated degradation of Cyclin D1, Oryza sativa" xref: Reactome:REACT_115913 "Cleavage of ERBB4m80 by gamma-scretase complex, Homo sapiens" xref: Reactome:REACT_1210 "Ubiquitinated Cdc6 is degraded by the proteasome, Homo sapiens" xref: Reactome:REACT_13413 "Proteasome mediated degradation of PAK-2p34, Homo sapiens" xref: Reactome:REACT_13491 "26S proteosome degrades ODC holoenzyme complex, Homo sapiens" xref: Reactome:REACT_13505 "Proteasome mediated degradation of PAK-2p34, Homo sapiens" xref: Reactome:REACT_1355 "Insulin degradation, Homo sapiens" xref: Reactome:REACT_13609 "gamma-secretase cleaves the p75NTR transmembrane domain, Homo sapiens" xref: Reactome:REACT_1471 "Ubiquitinated geminin is degraded by the proteasome, Homo sapiens" xref: Reactome:REACT_15476 "Corticotropin cleavage from POMC, Homo sapiens" xref: Reactome:REACT_1673 "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex, Homo sapiens" xref: Reactome:REACT_20637 "Proteasome mediated degradation of COP1, Homo sapiens" xref: Reactome:REACT_2142 "Proteasome mediated degradation of Cyclin D1, Homo sapiens" xref: Reactome:REACT_25343 "Destruction of AUF1 and mRNA, Homo sapiens" xref: Reactome:REACT_28448 "Ubiquitinated Orc1 is degraded by the proteasome, Dictyostelium discoideum" xref: Reactome:REACT_28452 "Proteasome mediated degradation of COP1, Bos taurus" xref: Reactome:REACT_28694 "Proteasome mediated degradation of Cyclin D1, Bos taurus" xref: Reactome:REACT_29497 "Corticotropin cleavage from POMC, Rattus norvegicus" xref: Reactome:REACT_29888 "Proteasome mediated degradation of COP1, Dictyostelium discoideum" xref: Reactome:REACT_30554 "APC/C:Cdh1-mediated degradation of Skp2, Mus musculus" xref: Reactome:REACT_31644 "Degradation of ubiquitinated -beta catenin by the proteasome, Mus musculus" xref: Reactome:REACT_32286 "Corticotropin cleavage from POMC, Gallus gallus" xref: Reactome:REACT_32345 "Proteasome mediated degradation of COP1, Rattus norvegicus" xref: Reactome:REACT_32454 "Corticotropin cleavage from POMC, Mus musculus" xref: Reactome:REACT_33103 "26S proteosome degrades ODC holoenzyme complex, Xenopus tropicalis" xref: Reactome:REACT_33361 "Degradation of multiubiquitinated Securin, Xenopus tropicalis" xref: Reactome:REACT_33702 "Proteasome mediated degradation of PAK-2p34, Drosophila melanogaster" xref: Reactome:REACT_34207 "Proteasome mediated degradation of PAK-2p34, Canis familiaris" xref: Reactome:REACT_34441 "Proteolytic degradation of ubiquitinated-Cdc25A, Rattus norvegicus" xref: Reactome:REACT_38775 "Ubiquitinated geminin is degraded by the proteasome, Bos taurus" xref: Reactome:REACT_480 "Ubiquitinated Orc1 is degraded by the proteasome, Homo sapiens" xref: Reactome:REACT_6715 "Degradation of multiubiquitinated Cdh1, Homo sapiens" xref: Reactome:REACT_6777 "Degradation of multiubiquitinated Securin, Homo sapiens" xref: Reactome:REACT_6826 "Degradation of multiubiquitinated cell cycle proteins, Homo sapiens" xref: Reactome:REACT_6878 "SCF-mediated degradation of Emi1, Homo sapiens" xref: Reactome:REACT_6937 "Degradation multiubiquitinated Cyclin A, Homo sapiens" xref: Reactome:REACT_75798 "Trimming of peptides in ER, Homo sapiens" xref: Reactome:REACT_75871 "Proteasomal cleavage of substrate, Homo sapiens" xref: Reactome:REACT_78097 "Proteasome mediated degradation of COP1, Canis familiaris" xref: Reactome:REACT_78726 "gamma-secretase cleaves the p75NTR transmembrane domain, Xenopus tropicalis" xref: Reactome:REACT_78745 "Proteasome mediated degradation of Cyclin D1, Drosophila melanogaster" xref: Reactome:REACT_78867 "Degradation multiubiquitinated Cyclin A, Rattus norvegicus" xref: Reactome:REACT_79225 "Degradation of multiubiquitinated Cdh1, Canis familiaris" xref: Reactome:REACT_79268 "Degradation of ubiquitinated -beta catenin by the proteasome, Drosophila melanogaster" xref: Reactome:REACT_79271 "Proteasome mediated degradation of Cyclin D1, Canis familiaris" xref: Reactome:REACT_79593 "Corticotropin cleavage from POMC, Xenopus tropicalis" xref: Reactome:REACT_79599 "26S proteosome degrades ODC holoenzyme complex, Danio rerio" xref: Reactome:REACT_79815 "gamma-secretase cleaves the p75NTR transmembrane domain, Gallus gallus" xref: Reactome:REACT_79882 "APC/C:Cdh1-mediated degradation of Skp2, Rattus norvegicus" xref: Reactome:REACT_80109 "gamma-secretase cleaves the p75NTR transmembrane domain, Danio rerio" xref: Reactome:REACT_80331 "APC/C:Cdh1-mediated degradation of Skp2, Xenopus tropicalis" xref: Reactome:REACT_80442 "Ubiquitinated Cdc6 is degraded by the proteasome, Drosophila melanogaster" xref: Reactome:REACT_80463 "Degradation of multiubiquitinated Securin, Danio rerio" xref: Reactome:REACT_80748 "Degradation multiubiquitinated Cyclin A, Bos taurus" xref: Reactome:REACT_80774 "Degradation of multiubiquitinated cell cycle proteins, Rattus norvegicus" xref: Reactome:REACT_80978 "Proteasome mediated degradation of PAK-2p34, Xenopus tropicalis" xref: Reactome:REACT_81238 "Corticotropin cleavage from POMC, Bos taurus" xref: Reactome:REACT_81327 "SCF-mediated degradation of Emi1, Mus musculus" xref: Reactome:REACT_81867 "Ubiquitinated Cdc6 is degraded by the proteasome, Bos taurus" xref: Reactome:REACT_81958 "Degradation of ubiquitinated p27/p21 by the 26S proteasome, Canis familiaris" xref: Reactome:REACT_82043 "Ubiquitinated Orc1 is degraded by the proteasome, Canis familiaris" xref: Reactome:REACT_82474 "Ubiquitinated Cdc6 is degraded by the proteasome, Dictyostelium discoideum" xref: Reactome:REACT_82600 "Degradation of multiubiquitinated cell cycle proteins, Xenopus tropicalis" xref: Reactome:REACT_82845 "26S proteosome degrades ODC holoenzyme complex, Rattus norvegicus" xref: Reactome:REACT_82963 "Degradation of multiubiquitinated cell cycle proteins, Drosophila melanogaster" xref: Reactome:REACT_83099 "Degradation of ubiquitinated p27/p21 by the 26S proteasome, Bos taurus" xref: Reactome:REACT_83216 "gamma-secretase cleaves the p75NTR transmembrane domain, Sus scrofa" xref: Reactome:REACT_83748 "Degradation of multiubiquitinated Cdh1, Drosophila melanogaster" xref: Reactome:REACT_84139 "Proteasome mediated degradation of COP1, Danio rerio" xref: Reactome:REACT_85078 "APC/C:Cdh1-mediated degradation of Skp2, Drosophila melanogaster" xref: Reactome:REACT_86353 "Corticotropin cleavage from POMC, Danio rerio" xref: Reactome:REACT_86565 "SCF-mediated degradation of Emi1, Rattus norvegicus" xref: Reactome:REACT_873 "Proteolytic degradation of ubiquitinated-Cdc25A, Homo sapiens" xref: Reactome:REACT_88382 "Proteasome mediated degradation of COP1, Mus musculus" xref: Reactome:REACT_88509 "Proteasome mediated degradation of Cyclin D1, Mus musculus" xref: Reactome:REACT_88535 "Ubiquitinated Orc1 is degraded by the proteasome, Plasmodium falciparum" xref: Reactome:REACT_88610 "Degradation multiubiquitinated Cyclin A, Canis familiaris" xref: Reactome:REACT_88818 "Degradation multiubiquitinated Cyclin A, Drosophila melanogaster" xref: Reactome:REACT_88854 "Corticotropin cleavage from POMC, Taeniopygia guttata" xref: Reactome:REACT_89011 "Ubiquitinated Orc1 is degraded by the proteasome, Rattus norvegicus" xref: Reactome:REACT_89036 "Ubiquitinated geminin is degraded by the proteasome, Danio rerio" xref: Reactome:REACT_89437 "26S proteosome degrades ODC holoenzyme complex, Bos taurus" xref: Reactome:REACT_89505 "Corticotropin cleavage from POMC, Sus scrofa" xref: Reactome:REACT_89706 "Degradation of multiubiquitinated Cdh1, Xenopus tropicalis" xref: Reactome:REACT_90062 "SCF-mediated degradation of Emi1, Canis familiaris" xref: Reactome:REACT_9018 "Degradation of ubiquitinated CD4, Homo sapiens" xref: Reactome:REACT_9034 "Degradation of ubiquitinated p27/p21 by the 26S proteasome, Homo sapiens" xref: Reactome:REACT_9035 "APC/C:Cdh1-mediated degradation of Skp2, Homo sapiens" xref: Reactome:REACT_90527 "SCF-mediated degradation of Emi1, Drosophila melanogaster" xref: Reactome:REACT_90608 "Proteasome mediated degradation of Cyclin D1, Danio rerio" xref: Reactome:REACT_91284 "Degradation of ubiquitinated -beta catenin by the proteasome, Bos taurus" xref: Reactome:REACT_91685 "Degradation of ubiquitinated -beta catenin by the proteasome, Rattus norvegicus" xref: Reactome:REACT_91903 "Ubiquitinated Cdc6 is degraded by the proteasome, Rattus norvegicus" xref: Reactome:REACT_92046 "Corticotropin cleavage from POMC, Canis familiaris" xref: Reactome:REACT_92221 "Ubiquitinated Cdc6 is degraded by the proteasome, Xenopus tropicalis" xref: Reactome:REACT_92347 "Proteasome mediated degradation of COP1, Oryza sativa" xref: Reactome:REACT_92586 "Degradation of ubiquitinated p27/p21 by the 26S proteasome, Xenopus tropicalis" xref: Reactome:REACT_92969 "Proteolytic degradation of ubiquitinated-Cdc25A, Bos taurus" xref: Reactome:REACT_93063 "Proteasome mediated degradation of PAK-2p34, Danio rerio" xref: Reactome:REACT_93174 "SCF-mediated degradation of Emi1, Xenopus tropicalis" xref: Reactome:REACT_93453 "Degradation of multiubiquitinated Cdh1, Mus musculus" xref: Reactome:REACT_93935 "gamma-secretase cleaves the p75NTR transmembrane domain, Mus musculus" xref: Reactome:REACT_94290 "Degradation of ubiquitinated p27/p21 by the 26S proteasome, Rattus norvegicus" xref: Reactome:REACT_9466 "Proteosome-mediated degradation of APOBEC3G, Homo sapiens" xref: Reactome:REACT_94694 "Degradation of multiubiquitinated Securin, Canis familiaris" xref: Reactome:REACT_95326 "Degradation of multiubiquitinated cell cycle proteins, Canis familiaris" xref: Reactome:REACT_95413 "Degradation of multiubiquitinated cell cycle proteins, Danio rerio" xref: Reactome:REACT_95513 "Proteolytic degradation of ubiquitinated-Cdc25A, Canis familiaris" xref: Reactome:REACT_95865 "Proteolytic degradation of ubiquitinated-Cdc25A, Mus musculus" xref: Reactome:REACT_96387 "Degradation multiubiquitinated Cyclin A, Mus musculus" xref: Reactome:REACT_96712 "Degradation of multiubiquitinated Securin, Drosophila melanogaster" xref: Reactome:REACT_96853 "Ubiquitinated Orc1 is degraded by the proteasome, Xenopus tropicalis" xref: Reactome:REACT_96908 "Ubiquitinated Orc1 is degraded by the proteasome, Drosophila melanogaster" xref: Reactome:REACT_97049 "Ubiquitinated Cdc6 is degraded by the proteasome, Oryza sativa" xref: Reactome:REACT_97235 "APC/C:Cdh1-mediated degradation of Skp2, Danio rerio" xref: Reactome:REACT_97302 "Proteasome mediated degradation of Cyclin D1, Xenopus tropicalis" xref: Reactome:REACT_97473 "Degradation of ubiquitinated p27/p21 by the 26S proteasome, Mus musculus" xref: Reactome:REACT_97709 "Degradation multiubiquitinated Cyclin A, Danio rerio" xref: Reactome:REACT_97826 "Degradation of multiubiquitinated cell cycle proteins, Bos taurus" xref: Reactome:REACT_97966 "APC/C:Cdh1-mediated degradation of Skp2, Oryza sativa" xref: Reactome:REACT_98412 "APC/C:Cdh1-mediated degradation of Skp2, Bos taurus" xref: Reactome:REACT_98429 "Degradation of ubiquitinated -beta catenin by the proteasome, Xenopus tropicalis" xref: Reactome:REACT_98617 "Degradation of multiubiquitinated Securin, Mus musculus" xref: Reactome:REACT_98707 "Proteasome mediated degradation of PAK-2p34, Rattus norvegicus" xref: Reactome:REACT_98822 "Degradation of multiubiquitinated Securin, Rattus norvegicus" xref: Reactome:REACT_98901 "Degradation of multiubiquitinated Securin, Bos taurus" xref: Reactome:REACT_98932 "Ubiquitinated geminin is degraded by the proteasome, Rattus norvegicus" xref: Reactome:REACT_99506 "26S proteosome degrades ODC holoenzyme complex, Mus musculus" xref: Reactome:REACT_99644 "Proteolytic degradation of ubiquitinated-Cdc25A, Drosophila melanogaster" is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004197 name: cysteine-type endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] subset: gosubset_prok synonym: "caspase activity" NARROW [GOC:mtg_apoptosis] synonym: "lysosomal cysteine-type endopeptidase" NARROW [] synonym: "metacaspase activity" NARROW [GOC:mtg_apoptosis] synonym: "thiol endopeptidase activity" EXACT [] xref: EC:3.4.22 xref: Reactome:REACT_100050 "Caspase-mediated cleavage of plectin-1, Mus musculus" xref: Reactome:REACT_100093 "Cleavage of Procaspase-7 by the apoptosome, Danio rerio" xref: Reactome:REACT_100258 "Caspase-mediated cleavage of PKC theta, Bos taurus" xref: Reactome:REACT_100371 "Caspase mediated cleavage of HIP-55, Rattus norvegicus" xref: Reactome:REACT_100591 "Caspase mediated cleavage of C-IAP1, Danio rerio" xref: Reactome:REACT_100749 "Caspase-mediated cleavage of vimentin at DSVD (85), Sus scrofa" xref: Reactome:REACT_100786 "Caspase mediated cleavage of BAP31, Sus scrofa" xref: Reactome:REACT_100806 "Caspase-mediated cleavage of E-Cadherin, Mus musculus" xref: Reactome:REACT_101275 "Caspase-mediated cleavage of claspin, Bos taurus" xref: Reactome:REACT_101388 "Caspase-mediated cleavage of Rock-1, Danio rerio" xref: Reactome:REACT_101482 "Caspase-mediated cleavage of vimentin at TNLD (429), Taeniopygia guttata" xref: Reactome:REACT_101496 "Caspase-mediated cleavage of Etk, Mus musculus" xref: Reactome:REACT_101535 "Caspase mediated cleavage of C-IAP1, Xenopus tropicalis" xref: Reactome:REACT_101617 "Caspase-mediated cleavage of GAS2, Danio rerio" xref: Reactome:REACT_102211 "Caspase-mediated cleavage of Desmoglein 2, Rattus norvegicus" xref: Reactome:REACT_102224 "Caspase-mediated cleavage of Lamin B1, Bos taurus" xref: Reactome:REACT_102308 "Caspase mediated cleavage of HIP-55, Sus scrofa" xref: Reactome:REACT_102448 "Cleavage of Procaspase-9 to Caspase-9, Gallus gallus" xref: Reactome:REACT_102624 "Caspase mediated cleavage of C-IAP1, Bos taurus" xref: Reactome:REACT_102731 "Caspase mediated cleavage of beta-catenin, Mus musculus" xref: Reactome:REACT_102903 "Caspase-mediated cleavage of FADK 1, Canis familiaris" xref: Reactome:REACT_103130 "Cleavage of Procaspase-7 by the apoptosome, Xenopus tropicalis" xref: Reactome:REACT_103265 "Cleavage of Satb1, Taeniopygia guttata" xref: Reactome:REACT_103288 "Caspase-mediated cleavage of Lamin B1, Xenopus tropicalis" xref: Reactome:REACT_103478 "Caspase mediated cleavage of APC, Danio rerio" xref: Reactome:REACT_103480 "Caspase-mediated cleavage of Tau, Sus scrofa" xref: Reactome:REACT_103527 "Cleavage of PAK-2 at 212, Sus scrofa" xref: Reactome:REACT_103538 "Caspase mediated cleavage of alpha-II-Fodrin, Gallus gallus" xref: Reactome:REACT_103796 "Caspase-mediated cleavage of Desmoglein 3, Taeniopygia guttata" xref: Reactome:REACT_103879 "Cleavage of Satb1, Gallus gallus" xref: Reactome:REACT_103993 "Cleavage of PAK-2 at 212, Mus musculus" xref: Reactome:REACT_103997 "Caspase-mediated cleavage of plectin-1, Danio rerio" xref: Reactome:REACT_104056 "Caspase mediated cleavage of APC, Taeniopygia guttata" xref: Reactome:REACT_104095 "Caspase-mediated cleavage of alpha adducin, Mus musculus" xref: Reactome:REACT_104234 "Caspase-mediated cleavage of Desmoglein 1, Mus musculus" xref: Reactome:REACT_104249 "Caspase mediated cleavage of alpha-II-Fodrin, Danio rerio" xref: Reactome:REACT_104338 "Legumain degrades DBP, Mus musculus" xref: Reactome:REACT_104344 "Caspase-mediated cleavage of Tau, Gallus gallus" xref: Reactome:REACT_104391 "Cleavage of Procaspase-7 by the apoptosome, Taeniopygia guttata" xref: Reactome:REACT_104407 "Caspase-mediated cleavage of Lamin B1, Danio rerio" xref: Reactome:REACT_104493 "Caspase-mediated cleavage of E-Cadherin, Rattus norvegicus" xref: Reactome:REACT_104700 "Caspase 3-mediated cleavage of PKC delta, Canis familiaris" xref: Reactome:REACT_104895 "Caspase-8 activates BID by cleavage, Mus musculus" xref: Reactome:REACT_105045 "Caspase-mediated cleavage of E-Cadherin, Gallus gallus" xref: Reactome:REACT_105170 "Caspase mediated cleavage of alpha-II-Fodrin, Mus musculus" xref: Reactome:REACT_105481 "Caspase-mediated cleavage of alpha adducin, Gallus gallus" xref: Reactome:REACT_105581 "Caspase-mediated cleavage of plectin-1, Bos taurus" xref: Reactome:REACT_105957 "Caspase-mediated cleavage of Rock-1, Rattus norvegicus" xref: Reactome:REACT_105958 "Caspase-mediated cleavage of MASK, Mus musculus" xref: Reactome:REACT_106680 "Caspase-mediated cleavage of GAS2, Rattus norvegicus" xref: Reactome:REACT_107019 "Caspase mediated cleavage of beta-catenin, Taeniopygia guttata" xref: Reactome:REACT_107128 "Cleavage of Satb1, Danio rerio" xref: Reactome:REACT_107302 "Caspase-mediated cleavage of Rock-1, Bos taurus" xref: Reactome:REACT_107511 "Caspase-mediated cleavage of Lamin A, Sus scrofa" xref: Reactome:REACT_107529 "Caspase-mediated cleavage of Lamin B1, Sus scrofa" xref: Reactome:REACT_107629 "Caspase-mediated cleavage of Lamin A, Drosophila melanogaster" xref: Reactome:REACT_107758 "Caspase mediated cleavage of beta-catenin, Danio rerio" xref: Reactome:REACT_107853 "Caspase-mediated cleavage of GAS2, Bos taurus" xref: Reactome:REACT_108026 "Caspase mediated cleavage of vimentin at IDVD (259), Taeniopygia guttata" xref: Reactome:REACT_108198 "Caspase-mediated cleavage of Lamin B1, Rattus norvegicus" xref: Reactome:REACT_108258 "Caspase-mediated cleavage of FADK 1, Taeniopygia guttata" xref: Reactome:REACT_108537 "Caspase-mediated cleavage of gelsolin, Mus musculus" xref: Reactome:REACT_108621 "Caspase mediated cleavage of beta-catenin, Sus scrofa" xref: Reactome:REACT_108783 "Caspase mediated cleavage of vimentin at IDVD (259), Danio rerio" xref: Reactome:REACT_108820 "Caspase-mediated cleavage of MASK, Canis familiaris" xref: Reactome:REACT_108938 "Caspase-mediated cleavage of MASK, Rattus norvegicus" xref: Reactome:REACT_108946 "Caspase-mediated cleavage of Lamin A, Gallus gallus" xref: Reactome:REACT_109026 "Caspase-mediated cleavage of PKC theta, Sus scrofa" xref: Reactome:REACT_109078 "Caspase-mediated cleavage of MASK, Taeniopygia guttata" xref: Reactome:REACT_109269 "Caspase-mediated cleavage of Etk, Canis familiaris" xref: Reactome:REACT_109374 "Caspase-mediated cleavage of Desmoglein 1, Danio rerio" xref: Reactome:REACT_109414 "Caspase mediated cleavage of APC, Xenopus tropicalis" xref: Reactome:REACT_109547 "Caspase-mediated cleavage of vimentin at DSVD (85), Taeniopygia guttata" xref: Reactome:REACT_109908 "Activation of caspase-3, Canis familiaris" xref: Reactome:REACT_110043 "Caspase-mediated cleavage of vimentin at TNLD (429), Danio rerio" xref: Reactome:REACT_110086 "Caspase-mediated cleavage of Desmoglein 2, Mus musculus" xref: Reactome:REACT_110544 "Caspase mediated cleavage of BAP31, Canis familiaris" xref: Reactome:REACT_110842 "Caspase-mediated cleavage of vimentin at DSVD (85), Xenopus tropicalis" xref: Reactome:REACT_111140 "Antigen processing by cathepsin S in endosoytic vesicle, Homo sapiens" xref: Reactome:REACT_111954 "Cleavage of Procaspase-7 by the apoptosome, Rattus norvegicus" xref: Reactome:REACT_112287 "Activation of caspase-3, Xenopus tropicalis" xref: Reactome:REACT_112363 "Cleavage of Procaspase-9 to Caspase-9, Sus scrofa" xref: Reactome:REACT_112407 "Caspase mediated cleavage of vimentin at IDVD (259), Caenorhabditis elegans" xref: Reactome:REACT_112426 "Caspase-mediated cleavage of Desmoglein 1, Xenopus tropicalis" xref: Reactome:REACT_112597 "Caspase-mediated cleavage of Desmoglein 3, Xenopus tropicalis" xref: Reactome:REACT_112616 "Cleavage of Procaspase-7 by the apoptosome, Sus scrofa" xref: Reactome:REACT_112859 "Cleavage of Procaspase-7 by the apoptosome, Canis familiaris" xref: Reactome:REACT_113141 "Cleavage of Procaspase-9 to Caspase-9, Canis familiaris" xref: Reactome:REACT_113588 "Caspase-mediated cleavage of Desmoglein 2, Xenopus tropicalis" xref: Reactome:REACT_114270 "Caspase mediated cleavage of alpha-II-Fodrin, Xenopus tropicalis" xref: Reactome:REACT_114571 "Cleavage of Procaspase-7 by the apoptosome, Bos taurus" xref: Reactome:REACT_114579 "Cleavage of Procaspase-9 to Caspase-9, Rattus norvegicus" xref: Reactome:REACT_114638 "Caspase-mediated cleavage of Acinus, Xenopus tropicalis" xref: Reactome:REACT_114872 "Caspase mediated cleavage of BAP31, Caenorhabditis elegans" xref: Reactome:REACT_115070 "Caspase-mediated cleavage of Rock-1, Canis familiaris" xref: Reactome:REACT_115318 "Caspase-mediated cleavage of plectin-1, Taeniopygia guttata" xref: Reactome:REACT_115379 "Cleavage of Procaspase-9 to Caspase-9, Bos taurus" xref: Reactome:REACT_11997 "Caspase-mediated cleavage of Desmoglein 1, Homo sapiens" xref: Reactome:REACT_12004 "Caspase-mediated cleavage of GAS2, Homo sapiens" xref: Reactome:REACT_12012 "Caspase mediated cleavage of APC, Homo sapiens" xref: Reactome:REACT_12014 "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha, Homo sapiens" xref: Reactome:REACT_12021 "Caspase-mediated cleavage of FADK 1, Homo sapiens" xref: Reactome:REACT_12022 "Caspase mediated cleavage of beta-catenin, Homo sapiens" xref: Reactome:REACT_12024 "Caspase mediated cleavage of alpha-II-Fodrin, Homo sapiens" xref: Reactome:REACT_12025 "Caspase mediated cleavage of HIP-55, Homo sapiens" xref: Reactome:REACT_12044 "Caspase-mediated cleavage of alpha adducin, Homo sapiens" xref: Reactome:REACT_12045 "Caspase mediated cleavage of C-IAP1, Homo sapiens" xref: Reactome:REACT_12072 "Caspase-mediated cleavage of E-Cadherin, Homo sapiens" xref: Reactome:REACT_12082 "Caspase-mediated cleavage of Desmoglein 3, Homo sapiens" xref: Reactome:REACT_12404 "Cleavage of DFF45 (224) by caspase-3, Homo sapiens" xref: Reactome:REACT_12450 "Caspase-mediated cleavage of Acinus, Homo sapiens" xref: Reactome:REACT_12471 "Caspase 3-mediated cleavage of PKC delta, Homo sapiens" xref: Reactome:REACT_12531 "Caspase-mediated cleavage of Rock-1, Homo sapiens" xref: Reactome:REACT_12544 "Caspase 3-mediated cleavage of DFF45 (117), Homo sapiens" xref: Reactome:REACT_12638 "Caspase-mediated cleavage of PKC theta, Homo sapiens" xref: Reactome:REACT_1320 "Caspase-8 activates BID by cleavage, Homo sapiens" xref: Reactome:REACT_13414 "Caspase-mediated cleavage of Tau, Homo sapiens" xref: Reactome:REACT_13417 "Caspase-mediated cleavage of Etk, Homo sapiens" xref: Reactome:REACT_13418 "Caspase-mediated cleavage of plakophilin-1, Homo sapiens" xref: Reactome:REACT_13428 "Caspase-mediated cleavage of vimentin at DSVD (85), Homo sapiens" xref: Reactome:REACT_13466 "Cleavage of PAK-2 at 212, Oryctolagus cuniculus" xref: Reactome:REACT_13468 "Caspase-mediated cleavage of MST3, Homo sapiens" xref: Reactome:REACT_13476 "Caspase-mediated cleavage of Lamin A, Homo sapiens" xref: Reactome:REACT_13484 "Caspase-mediated cleavage of Lamin B1, Homo sapiens" xref: Reactome:REACT_13489 "Caspase mediated cleavage of vimentin at IDVD (259), Homo sapiens" xref: Reactome:REACT_13519 "Caspase-mediated cleavage of vimentin at TNLD (429), Homo sapiens" xref: Reactome:REACT_13522 "Caspase-mediated cleavage of plectin-1, Homo sapiens" xref: Reactome:REACT_13549 "Caspase-mediated cleavage of occludin, Homo sapiens" xref: Reactome:REACT_13554 "Caspase mediated cleavage of BAP31, Homo sapiens" xref: Reactome:REACT_13587 "Caspase-mediated cleavage of Z0-1, Homo sapiens" xref: Reactome:REACT_13598 "Caspase-mediated cleavage of Desmoglein 2, Homo sapiens" xref: Reactome:REACT_13605 "Caspase-mediated cleavage of Desmoplakin, Homo sapiens" xref: Reactome:REACT_13636 "Caspase-mediated cleavage of MASK, Homo sapiens" xref: Reactome:REACT_13652 "Caspase-mediated cleavage of claspin, Homo sapiens" xref: Reactome:REACT_13664 "Legumain degrades DBP, Homo sapiens" xref: Reactome:REACT_13747 "Cleavage of PAK-2 at 212, Homo sapiens" xref: Reactome:REACT_13795 "Caspase-mediated cleavage of gelsolin, Homo sapiens" xref: Reactome:REACT_13813 "Caspase-mediated cleavage of Z0-2, Homo sapiens" xref: Reactome:REACT_2116 "Cleavage of Procaspase-9 to Caspase-9, Homo sapiens" xref: Reactome:REACT_2165 "Cleavage of Procaspase-7 by the apoptosome, Homo sapiens" xref: Reactome:REACT_22184 "Caspase cleavage of UNC5A, Homo sapiens" xref: Reactome:REACT_22225 "Cleavage of Satb1, Homo sapiens" xref: Reactome:REACT_22343 "Caspase cleavage of UNC5B, Homo sapiens" xref: Reactome:REACT_22367 "Caspase cleavage of Unc5h1, Mus musculus" xref: Reactome:REACT_22412 "Activation of caspase-3, Homo sapiens" xref: Reactome:REACT_22420 "Caspase cleavage of Unc5h2, Mus musculus" xref: Reactome:REACT_22440 "Caspase cleavage of DCC, Homo sapiens" xref: Reactome:REACT_24999 "Processing of caspases, Homo sapiens" xref: Reactome:REACT_28312 "Caspase-mediated cleavage of PKC theta, Rattus norvegicus" xref: Reactome:REACT_28479 "Caspase-mediated cleavage of Etk, Bos taurus" xref: Reactome:REACT_28628 "Caspase-mediated cleavage of alpha adducin, Canis familiaris" xref: Reactome:REACT_28846 "Caspase-mediated cleavage of Acinus, Mus musculus" xref: Reactome:REACT_28869 "Cleavage of Procaspase-7 by the apoptosome, Gallus gallus" xref: Reactome:REACT_29115 "Caspase-8 activates BID by cleavage, Canis familiaris" xref: Reactome:REACT_29150 "Caspase mediated cleavage of vimentin at IDVD (259), Canis familiaris" xref: Reactome:REACT_29160 "Caspase 3-mediated cleavage of DFF45 (117), Sus scrofa" xref: Reactome:REACT_29351 "Cleavage of Procaspase-9 to Caspase-9, Danio rerio" xref: Reactome:REACT_29430 "Caspase-mediated cleavage of claspin, Canis familiaris" xref: Reactome:REACT_29547 "Caspase mediated cleavage of HIP-55, Bos taurus" xref: Reactome:REACT_29647 "Caspase-mediated cleavage of claspin, Gallus gallus" xref: Reactome:REACT_29743 "Caspase-mediated cleavage of GAS2, Taeniopygia guttata" xref: Reactome:REACT_29821 "Caspase-mediated cleavage of Lamin B1, Canis familiaris" xref: Reactome:REACT_30047 "Caspase mediated cleavage of APC, Mus musculus" xref: Reactome:REACT_30276 "Legumain degrades DBP, Gallus gallus" xref: Reactome:REACT_30300 "Caspase mediated cleavage of APC, Sus scrofa" xref: Reactome:REACT_30513 "Caspase mediated cleavage of APC, Rattus norvegicus" xref: Reactome:REACT_30561 "Legumain degrades DBP, Canis familiaris" xref: Reactome:REACT_30860 "Caspase-mediated cleavage of FADK 1, Danio rerio" xref: Reactome:REACT_31037 "Activation of caspase-3, Danio rerio" xref: Reactome:REACT_31043 "Caspase mediated cleavage of beta-catenin, Canis familiaris" xref: Reactome:REACT_31510 "Caspase-mediated cleavage of gelsolin, Bos taurus" xref: Reactome:REACT_31594 "Caspase mediated cleavage of beta-catenin, Xenopus tropicalis" xref: Reactome:REACT_31912 "Caspase 3-mediated cleavage of PKC delta, Taeniopygia guttata" xref: Reactome:REACT_31993 "Cleavage of PAK-2 at 212, Danio rerio" xref: Reactome:REACT_32081 "Caspase-mediated cleavage of E-Cadherin, Canis familiaris" xref: Reactome:REACT_32092 "Caspase mediated cleavage of C-IAP1, Canis familiaris" xref: Reactome:REACT_32303 "Cleavage of Satb1, Canis familiaris" xref: Reactome:REACT_32343 "Legumain degrades DBP, Danio rerio" xref: Reactome:REACT_32649 "Caspase mediated cleavage of vimentin at IDVD (259), Mus musculus" xref: Reactome:REACT_32982 "Caspase-mediated cleavage of Desmoglein 3, Rattus norvegicus" xref: Reactome:REACT_33284 "Caspase mediated cleavage of HIP-55, Xenopus tropicalis" xref: Reactome:REACT_33786 "Caspase-mediated cleavage of Desmoglein 2, Danio rerio" xref: Reactome:REACT_33971 "Caspase-mediated cleavage of FADK 1, Rattus norvegicus" xref: Reactome:REACT_34082 "Caspase mediated cleavage of alpha-II-Fodrin, Taeniopygia guttata" xref: Reactome:REACT_34279 "Caspase-mediated cleavage of Desmoglein 2, Taeniopygia guttata" xref: Reactome:REACT_34342 "Caspase mediated cleavage of vimentin at IDVD (259), Rattus norvegicus" xref: Reactome:REACT_34469 "Caspase-mediated cleavage of MASK, Danio rerio" xref: Reactome:REACT_34743 "Cleavage of Procaspase-9 to Caspase-9, Xenopus tropicalis" xref: Reactome:REACT_34768 "Caspase-mediated cleavage of plectin-1, Rattus norvegicus" xref: Reactome:REACT_34770 "Caspase 3-mediated cleavage of PKC delta, Bos taurus" xref: Reactome:REACT_40493 "Caspase 3-mediated cleavage of PKC delta, Mus musculus" xref: Reactome:REACT_45490 "Caspase 3-mediated cleavage of DFF45 (117), Canis familiaris" xref: Reactome:REACT_65200 "Caspase mediated cleavage of HIP-55, Mus musculus" xref: Reactome:REACT_66649 "Caspase-mediated cleavage of FADK 1, Gallus gallus" xref: Reactome:REACT_69471 "Caspase-mediated cleavage of Lamin B1, Mus musculus" xref: Reactome:REACT_77064 "Cleavage of DFF45 (224) by caspase-3, Sus scrofa" xref: Reactome:REACT_77154 "Caspase-mediated cleavage of Lamin A, Bos taurus" xref: Reactome:REACT_77197 "Caspase 3-mediated cleavage of DFF45 (117), Taeniopygia guttata" xref: Reactome:REACT_77210 "Caspase-mediated cleavage of FADK 1, Sus scrofa" xref: Reactome:REACT_77248 "Cleavage of PAK-2 at 212, Taeniopygia guttata" xref: Reactome:REACT_77301 "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha, Taeniopygia guttata" xref: Reactome:REACT_77309 "Caspase mediated cleavage of HIP-55, Canis familiaris" xref: Reactome:REACT_77343 "Caspase-mediated cleavage of Acinus, Sus scrofa" xref: Reactome:REACT_77434 "Caspase 3-mediated cleavage of DFF45 (117), Gallus gallus" xref: Reactome:REACT_77678 "Caspase-mediated cleavage of Rock-1, Mus musculus" xref: Reactome:REACT_77795 "Cleavage of Satb1, Xenopus tropicalis" xref: Reactome:REACT_77916 "Caspase-mediated cleavage of vimentin at TNLD (429), Bos taurus" xref: Reactome:REACT_77921 "Caspase mediated cleavage of APC, Bos taurus" xref: Reactome:REACT_78072 "Cleavage of DFF45 (224) by caspase-3, Xenopus tropicalis" xref: Reactome:REACT_78179 "Caspase-8 activates BID by cleavage, Rattus norvegicus" xref: Reactome:REACT_78180 "Caspase-mediated cleavage of Lamin B1, Gallus gallus" xref: Reactome:REACT_78322 "Caspase mediated cleavage of C-IAP1, Taeniopygia guttata" xref: Reactome:REACT_78407 "Caspase mediated cleavage of beta-catenin, Rattus norvegicus" xref: Reactome:REACT_78676 "Caspase-mediated cleavage of Rock-1, Xenopus tropicalis" xref: Reactome:REACT_78896 "Caspase-mediated cleavage of Lamin A, Canis familiaris" xref: Reactome:REACT_78931 "Caspase-mediated cleavage of E-Cadherin, Taeniopygia guttata" xref: Reactome:REACT_78958 "Caspase 3-mediated cleavage of PKC delta, Xenopus tropicalis" xref: Reactome:REACT_79257 "Caspase-mediated cleavage of claspin, Xenopus tropicalis" xref: Reactome:REACT_79283 "Caspase-mediated cleavage of Acinus, Bos taurus" xref: Reactome:REACT_79470 "Caspase mediated cleavage of BAP31, Rattus norvegicus" xref: Reactome:REACT_79514 "Cleavage of Satb1, Bos taurus" xref: Reactome:REACT_79541 "Caspase-mediated cleavage of vimentin at DSVD (85), Canis familiaris" xref: Reactome:REACT_79778 "Caspase-mediated cleavage of vimentin at TNLD (429), Rattus norvegicus" xref: Reactome:REACT_79895 "Caspase-mediated cleavage of vimentin at TNLD (429), Xenopus tropicalis" xref: Reactome:REACT_79950 "Caspase mediated cleavage of APC, Canis familiaris" xref: Reactome:REACT_80378 "Caspase mediated cleavage of HIP-55, Gallus gallus" xref: Reactome:REACT_80953 "Caspase-mediated cleavage of Desmoglein 3, Mus musculus" xref: Reactome:REACT_80998 "Caspase mediated cleavage of C-IAP1, Mus musculus" xref: Reactome:REACT_81124 "Caspase-mediated cleavage of Desmoglein 2, Gallus gallus" xref: Reactome:REACT_81156 "Caspase-mediated cleavage of vimentin at TNLD (429), Mus musculus" xref: Reactome:REACT_81371 "Caspase-mediated cleavage of vimentin at DSVD (85), Mus musculus" xref: Reactome:REACT_81496 "Caspase-mediated cleavage of GAS2, Canis familiaris" xref: Reactome:REACT_81521 "Caspase 3-mediated cleavage of DFF45 (117), Mus musculus" xref: Reactome:REACT_81570 "Caspase-mediated cleavage of Tau, Mus musculus" xref: Reactome:REACT_81606 "Caspase mediated cleavage of alpha-II-Fodrin, Bos taurus" xref: Reactome:REACT_81720 "Cleavage of Procaspase-9 to Caspase-9, Mus musculus" xref: Reactome:REACT_81816 "Cleavage of DFF45 (224) by caspase-3, Danio rerio" xref: Reactome:REACT_81951 "Caspase mediated cleavage of BAP31, Danio rerio" xref: Reactome:REACT_82352 "Cleavage of Satb1, Sus scrofa" xref: Reactome:REACT_82992 "Caspase-mediated cleavage of MASK, Gallus gallus" xref: Reactome:REACT_83002 "Cleavage of Procaspase-9 to Caspase-9, Taeniopygia guttata" xref: Reactome:REACT_83106 "Caspase-mediated cleavage of FADK 1, Mus musculus" xref: Reactome:REACT_83519 "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha, Mus musculus" xref: Reactome:REACT_83624 "Caspase-mediated cleavage of MASK, Xenopus tropicalis" xref: Reactome:REACT_83683 "Caspase-mediated cleavage of vimentin at TNLD (429), Gallus gallus" xref: Reactome:REACT_84133 "Caspase-mediated cleavage of plectin-1, Canis familiaris" xref: Reactome:REACT_84494 "Caspase-mediated cleavage of Desmoglein 2, Canis familiaris" xref: Reactome:REACT_84645 "Caspase 3-mediated cleavage of DFF45 (117), Rattus norvegicus" xref: Reactome:REACT_84845 "Cleavage of PAK-2 at 212, Canis familiaris" xref: Reactome:REACT_84872 "Caspase-mediated cleavage of Acinus, Danio rerio" xref: Reactome:REACT_84905 "Caspase-8 activates BID by cleavage, Taeniopygia guttata" xref: Reactome:REACT_84967 "Caspase-mediated cleavage of Desmoglein 1, Canis familiaris" xref: Reactome:REACT_84971 "Cleavage of PAK-2 at 212, Xenopus tropicalis" xref: Reactome:REACT_85027 "Caspase-mediated cleavage of Tau, Rattus norvegicus" xref: Reactome:REACT_85032 "Caspase mediated cleavage of HIP-55, Danio rerio" xref: Reactome:REACT_85270 "Caspase mediated cleavage of BAP31, Mus musculus" xref: Reactome:REACT_85285 "Caspase-mediated cleavage of alpha adducin, Sus scrofa" xref: Reactome:REACT_85370 "Caspase-mediated cleavage of vimentin at DSVD (85), Bos taurus" xref: Reactome:REACT_85432 "Cleavage of PAK-2 at 212, Gallus gallus" xref: Reactome:REACT_85447 "Caspase-mediated cleavage of Tau, Canis familiaris" xref: Reactome:REACT_85559 "Caspase-mediated cleavage of Desmoglein 1, Gallus gallus" xref: Reactome:REACT_85681 "Caspase-mediated cleavage of alpha adducin, Xenopus tropicalis" xref: Reactome:REACT_85820 "Caspase 3-mediated cleavage of PKC delta, Rattus norvegicus" xref: Reactome:REACT_85958 "Caspase-mediated cleavage of Etk, Gallus gallus" xref: Reactome:REACT_86010 "Caspase-mediated cleavage of Desmoglein 3, Gallus gallus" xref: Reactome:REACT_86094 "Caspase-mediated cleavage of vimentin at TNLD (429), Sus scrofa" xref: Reactome:REACT_86100 "Caspase-mediated cleavage of Rock-1, Taeniopygia guttata" xref: Reactome:REACT_86150 "Caspase mediated cleavage of alpha-II-Fodrin, Rattus norvegicus" xref: Reactome:REACT_86362 "Caspase-mediated cleavage of MASK, Bos taurus" xref: Reactome:REACT_86384 "Caspase-mediated cleavage of PKC theta, Mus musculus" xref: Reactome:REACT_86398 "Caspase mediated cleavage of C-IAP1, Rattus norvegicus" xref: Reactome:REACT_86436 "Caspase-mediated cleavage of claspin, Rattus norvegicus" xref: Reactome:REACT_86545 "Caspase mediated cleavage of vimentin at IDVD (259), Sus scrofa" xref: Reactome:REACT_86791 "Caspase-mediated cleavage of Tau, Taeniopygia guttata" xref: Reactome:REACT_86903 "Caspase mediated cleavage of HIP-55, Taeniopygia guttata" xref: Reactome:REACT_86932 "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha, Canis familiaris" xref: Reactome:REACT_87309 "Legumain degrades DBP, Rattus norvegicus" xref: Reactome:REACT_87440 "Caspase-mediated cleavage of vimentin at DSVD (85), Gallus gallus" xref: Reactome:REACT_87658 "Caspase mediated cleavage of vimentin at IDVD (259), Bos taurus" xref: Reactome:REACT_87895 "Caspase-mediated cleavage of claspin, Mus musculus" xref: Reactome:REACT_87973 "Caspase-mediated cleavage of FADK 1, Xenopus tropicalis" xref: Reactome:REACT_88107 "Caspase-mediated cleavage of claspin, Danio rerio" xref: Reactome:REACT_88165 "Cleavage of DFF45 (224) by caspase-3, Gallus gallus" xref: Reactome:REACT_88929 "Caspase-8 activates BID by cleavage, Sus scrofa" xref: Reactome:REACT_89449 "Caspase-mediated cleavage of alpha adducin, Taeniopygia guttata" xref: Reactome:REACT_89531 "Caspase 3-mediated cleavage of PKC delta, Danio rerio" xref: Reactome:REACT_89573 "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha, Rattus norvegicus" xref: Reactome:REACT_89708 "Cleavage of DFF45 (224) by caspase-3, Rattus norvegicus" xref: Reactome:REACT_90001 "Caspase-mediated cleavage of FADK 1, Bos taurus" xref: Reactome:REACT_90025 "Caspase-mediated cleavage of PKC theta, Taeniopygia guttata" xref: Reactome:REACT_90026 "Caspase-mediated cleavage of vimentin at DSVD (85), Danio rerio" xref: Reactome:REACT_90780 "Cleavage of Procaspase-7 by the apoptosome, Mus musculus" xref: Reactome:REACT_90840 "Caspase-mediated cleavage of Desmoglein 3, Danio rerio" xref: Reactome:REACT_90898 "Caspase-mediated cleavage of Lamin A, Danio rerio" xref: Reactome:REACT_91339 "Cleavage of Satb1, Rattus norvegicus" xref: Reactome:REACT_91358 "Caspase 3-mediated cleavage of DFF45 (117), Xenopus tropicalis" xref: Reactome:REACT_91380 "Caspase-mediated cleavage of gelsolin, Canis familiaris" xref: Reactome:REACT_91436 "Caspase-mediated cleavage of Lamin A, Xenopus tropicalis" xref: Reactome:REACT_91694 "Caspase-mediated cleavage of claspin, Sus scrofa" xref: Reactome:REACT_91811 "Caspase-mediated cleavage of claspin, Taeniopygia guttata" xref: Reactome:REACT_91825 "Caspase-mediated cleavage of GAS2, Mus musculus" xref: Reactome:REACT_91992 "Caspase-mediated cleavage of Lamin B1, Taeniopygia guttata" xref: Reactome:REACT_92095 "Cleavage of DFF45 (224) by caspase-3, Taeniopygia guttata" xref: Reactome:REACT_92317 "Caspase mediated cleavage of alpha-II-Fodrin, Sus scrofa" xref: Reactome:REACT_92549 "Caspase-mediated cleavage of Acinus, Rattus norvegicus" xref: Reactome:REACT_92604 "Caspase mediated cleavage of BAP31, Bos taurus" xref: Reactome:REACT_92733 "Caspase-mediated cleavage of E-Cadherin, Danio rerio" xref: Reactome:REACT_93115 "Caspase-mediated cleavage of vimentin at TNLD (429), Canis familiaris" xref: Reactome:REACT_93215 "Caspase-mediated cleavage of gelsolin, Rattus norvegicus" xref: Reactome:REACT_93489 "Caspase-mediated cleavage of Acinus, Canis familiaris" xref: Reactome:REACT_93620 "Caspase-mediated cleavage of E-Cadherin, Bos taurus" xref: Reactome:REACT_93838 "Cleavage of DFF45 (224) by caspase-3, Bos taurus" xref: Reactome:REACT_93845 "Caspase-mediated cleavage of Desmoglein 1, Rattus norvegicus" xref: Reactome:REACT_93876 "Caspase-mediated cleavage of Tau, Danio rerio" xref: Reactome:REACT_94219 "Cleavage of DFF45 (224) by caspase-3, Canis familiaris" xref: Reactome:REACT_94280 "Caspase-mediated cleavage of Desmoglein 1, Taeniopygia guttata" xref: Reactome:REACT_94301 "Caspase-8 activates BID by cleavage, Gallus gallus" xref: Reactome:REACT_94351 "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha, Danio rerio" xref: Reactome:REACT_94538 "Caspase 3-mediated cleavage of PKC delta, Gallus gallus" xref: Reactome:REACT_94598 "Caspase 3-mediated cleavage of DFF45 (117), Bos taurus" xref: Reactome:REACT_94641 "Caspase-mediated cleavage of alpha adducin, Rattus norvegicus" xref: Reactome:REACT_94673 "Caspase-8 activates BID by cleavage, Bos taurus" xref: Reactome:REACT_94680 "Caspase-mediated cleavage of Tau, Bos taurus" xref: Reactome:REACT_95121 "Caspase-mediated cleavage of GAS2, Gallus gallus" xref: Reactome:REACT_95172 "Caspase mediated cleavage of beta-catenin, Gallus gallus" xref: Reactome:REACT_95220 "Caspase-mediated cleavage of Tau, Xenopus tropicalis" xref: Reactome:REACT_95222 "Caspase-mediated cleavage of Desmoglein 3, Canis familiaris" xref: Reactome:REACT_95242 "Caspase mediated cleavage of alpha-II-Fodrin, Canis familiaris" xref: Reactome:REACT_95283 "Caspase-mediated cleavage of alpha adducin, Bos taurus" xref: Reactome:REACT_95420 "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha, Bos taurus" xref: Reactome:REACT_95652 "Caspase mediated cleavage of APC, Gallus gallus" xref: Reactome:REACT_95884 "Caspase mediated cleavage of beta-catenin, Bos taurus" xref: Reactome:REACT_95944 "Caspase-mediated cleavage of PKC theta, Canis familiaris" xref: Reactome:REACT_95948 "Caspase-mediated cleavage of Rock-1, Gallus gallus" xref: Reactome:REACT_96025 "Caspase-mediated cleavage of GAS2, Xenopus tropicalis" xref: Reactome:REACT_96048 "Caspase 3-mediated cleavage of DFF45 (117), Danio rerio" xref: Reactome:REACT_96146 "Caspase-mediated cleavage of PKC theta, Gallus gallus" xref: Reactome:REACT_96219 "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha, Xenopus tropicalis" xref: Reactome:REACT_96672 "Caspase-mediated cleavage of gelsolin, Danio rerio" xref: Reactome:REACT_96721 "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha, Gallus gallus" xref: Reactome:REACT_96744 "Caspase-mediated cleavage of vimentin at DSVD (85), Rattus norvegicus" xref: Reactome:REACT_96941 "Cleavage of Satb1, Mus musculus" xref: Reactome:REACT_97519 "Cleavage of PAK-2 at 212, Rattus norvegicus" xref: Reactome:REACT_97541 "Caspase-mediated cleavage of PKC theta, Xenopus tropicalis" xref: Reactome:REACT_97621 "Caspase mediated cleavage of vimentin at IDVD (259), Gallus gallus" xref: Reactome:REACT_97639 "Caspase-mediated cleavage of Lamin B1, Drosophila melanogaster" xref: Reactome:REACT_97875 "Legumain degrades DBP, Xenopus tropicalis" xref: Reactome:REACT_97995 "Caspase-mediated cleavage of Lamin A, Taeniopygia guttata" xref: Reactome:REACT_98036 "Activation of caspase-3, Rattus norvegicus" xref: Reactome:REACT_98139 "Caspase-mediated cleavage of Desmoglein 3, Bos taurus" xref: Reactome:REACT_98180 "Cleavage of DFF45 (224) by caspase-3, Mus musculus" xref: Reactome:REACT_98289 "Caspase-mediated cleavage of Lamin A, Mus musculus" xref: Reactome:REACT_98423 "Caspase-mediated cleavage of Desmoglein 2, Bos taurus" xref: Reactome:REACT_98483 "Caspase-mediated cleavage of Etk, Rattus norvegicus" xref: Reactome:REACT_98534 "Caspase-mediated cleavage of Lamin A, Rattus norvegicus" xref: Reactome:REACT_98703 "Caspase-mediated cleavage of alpha adducin, Danio rerio" xref: Reactome:REACT_98831 "Caspase mediated cleavage of C-IAP1, Gallus gallus" xref: Reactome:REACT_98986 "Caspase-mediated cleavage of gelsolin, Gallus gallus" xref: Reactome:REACT_99229 "Caspase-mediated cleavage of PKC theta, Danio rerio" xref: Reactome:REACT_99392 "Caspase-mediated cleavage of Etk, Sus scrofa" xref: Reactome:REACT_99637 "Activation of caspase-3, Mus musculus" xref: Reactome:REACT_99764 "Caspase-mediated cleavage of Desmoglein 1, Bos taurus" is_a: GO:0004175 ! endopeptidase activity is_a: GO:0008234 ! cysteine-type peptidase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004311 name: farnesyltranstransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate." [EC:2.5.1.29, RHEA:17656] comment: The catalyzed reaction forms (free) geranylgeranyl diphosphate. There is no relationship between this activity and protein farnesyltransferase activity, GO:0004660, where the catalyzed reaction transfers a farnesyl group from farnesyl diphosphate to a target protein. subset: gosubset_prok synonym: "farnesyltransferase activity" BROAD [EC:2.5.1.29] synonym: "geranylgeranyl pyrophosphate synthase activity" EXACT [EC:2.5.1.29] synonym: "geranylgeranyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.29] synonym: "geranylgeranyl-diphosphate synthase activity" EXACT [EC:2.5.1.29] synonym: "geranylgeranyl-PP synthetase activity" EXACT [EC:2.5.1.29] synonym: "trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity" EXACT [EC:2.5.1.29] xref: EC:2.5.1.29 xref: KEGG:R02061 xref: MetaCyc:FARNESYLTRANSTRANSFERASE-RXN xref: RHEA:17656 is_a: GO:0004659 ! prenyltransferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004312 name: fatty acid synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+." [EC:2.3.1.85] subset: gosubset_prok synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)" EXACT [EC:2.3.1.85] synonym: "fatty-acid synthase activity" EXACT [] xref: EC:2.3.1.85 xref: MetaCyc:FATTY-ACID-SYNTHASE-RXN xref: Reactome:REACT_112198 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Mycobacterium tuberculosis" xref: Reactome:REACT_113128 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Dictyostelium discoideum" xref: Reactome:REACT_1497 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Homo sapiens" xref: Reactome:REACT_28371 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Danio rerio" xref: Reactome:REACT_78047 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Xenopus tropicalis" xref: Reactome:REACT_81687 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Mus musculus" xref: Reactome:REACT_81811 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Drosophila melanogaster" xref: Reactome:REACT_83657 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Gallus gallus" xref: Reactome:REACT_83733 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Canis familiaris" xref: Reactome:REACT_91445 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Taeniopygia guttata" xref: Reactome:REACT_96308 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Bos taurus" xref: Reactome:REACT_97636 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O, Caenorhabditis elegans" is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004352 name: glutamate dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+." [EC:1.4.1.2] subset: gosubset_prok synonym: "glutamate dehydrogenase (NAD)" EXACT [EC:1.4.1.2] synonym: "glutamate oxidoreductase activity" EXACT [EC:1.4.1.2] synonym: "glutamic acid dehydrogenase" BROAD [EC:1.4.1.2] synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.2] synonym: "L-glutamate dehydrogenase" BROAD [EC:1.4.1.2] synonym: "L-glutamate:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.2] synonym: "NAD-dependent glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-dependent glutamic dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-linked glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-linked glutamic dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-specific glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-specific glutamic dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD:glutamate oxidoreductase activity" EXACT [EC:1.4.1.2] synonym: "NADH-linked glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] xref: EC:1.4.1.2 xref: MetaCyc:GLUTAMATE-DEHYDROGENASE-RXN xref: RHEA:15136 is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004354 name: glutamate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+." [EC:1.4.1.4] subset: gosubset_prok synonym: "dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))" EXACT [EC:1.4.1.4] synonym: "glutamic acid dehydrogenase" BROAD [EC:1.4.1.4] synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.4] synonym: "L-glutamate dehydrogenase" BROAD [EC:1.4.1.4] synonym: "L-glutamate:NADP+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.4] synonym: "L-glutamic acid dehydrogenase activity" EXACT [EC:1.4.1.4] synonym: "NAD(P)-glutamate dehydrogenase activity" EXACT [EC:1.4.1.4] synonym: "NAD(P)H-dependent glutamate dehydrogenase activity" EXACT [EC:1.4.1.4] xref: EC:1.4.1.4 xref: MetaCyc:GLUTDEHYD-RXN xref: MetaCyc:GLUTSYNIII-PWY xref: RHEA:11615 is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004356 name: glutamate-ammonia ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + ATP + NH(4)(+) = L-glutamine + ADP + 2 H(+) + phosphate." [EC:6.3.1.2, RHEA:16172] subset: gosubset_prok synonym: "glutamine synthetase activity" EXACT [] synonym: "glutamylhydroxamic synthetase activity" EXACT [EC:6.3.1.2] synonym: "L-glutamate:ammonia ligase (ADP-forming)" EXACT [EC:6.3.1.2] synonym: "L-glutamine synthetase activity" EXACT [EC:6.3.1.2] xref: EC:6.3.1.2 xref: KEGG:R00253 xref: MetaCyc:GLUTAMINESYN-RXN xref: Reactome:REACT_104006 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Danio rerio" xref: Reactome:REACT_104940 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Drosophila melanogaster" xref: Reactome:REACT_110265 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Gallus gallus" xref: Reactome:REACT_112105 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Oryza sativa" xref: Reactome:REACT_115035 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Arabidopsis thaliana" xref: Reactome:REACT_1171 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Homo sapiens" xref: Reactome:REACT_28913 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Sus scrofa" xref: Reactome:REACT_33705 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Canis familiaris" xref: Reactome:REACT_34384 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Saccharomyces cerevisiae" xref: Reactome:REACT_39662 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Caenorhabditis elegans" xref: Reactome:REACT_77424 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Bos taurus" xref: Reactome:REACT_77661 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Schizosaccharomyces pombe" xref: Reactome:REACT_86685 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Xenopus tropicalis" xref: Reactome:REACT_90402 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Mus musculus" xref: Reactome:REACT_90408 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Taeniopygia guttata" xref: Reactome:REACT_92620 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL], Rattus norvegicus" xref: RHEA:16172 is_a: GO:0016211 ! ammonia ligase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004357 name: glutamate-cysteine ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate." [EC:6.3.2.2, RHEA:13288] subset: gosubset_prok synonym: "gamma-glutamyl-L-cysteine synthetase activity" EXACT [EC:6.3.2.2] synonym: "gamma-glutamylcysteine synthetase activity" EXACT [EC:6.3.2.2] synonym: "gamma-glutamylcysteinyl synthetase activity" EXACT [EC:6.3.2.2] synonym: "L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity" EXACT [EC:6.3.2.2] xref: EC:6.3.2.2 xref: KEGG:R00894 xref: MetaCyc:GLUTCYSLIG-RXN xref: Reactome:REACT_28974 "Glutamate and cysteine combine, Schizosaccharomyces pombe" xref: Reactome:REACT_29140 "Glutamate and cysteine combine, Sus scrofa" xref: Reactome:REACT_30350 "Glutamate and cysteine combine, Mus musculus" xref: Reactome:REACT_32418 "Glutamate and cysteine combine, Rattus norvegicus" xref: Reactome:REACT_6970 "Glutamate and cysteine combine, Homo sapiens" xref: Reactome:REACT_79569 "Glutamate and cysteine combine, Canis familiaris" xref: Reactome:REACT_82470 "Glutamate and cysteine combine, Xenopus tropicalis" xref: Reactome:REACT_88007 "Glutamate and cysteine combine, Gallus gallus" xref: Reactome:REACT_90345 "Glutamate and cysteine combine, Taeniopygia guttata" xref: Reactome:REACT_91026 "Glutamate and cysteine combine, Danio rerio" xref: Reactome:REACT_96699 "Glutamate and cysteine combine, Drosophila melanogaster" xref: Reactome:REACT_99078 "Glutamate and cysteine combine, Caenorhabditis elegans" xref: RHEA:13288 is_a: GO:0016881 ! acid-amino acid ligase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004362 name: glutathione-disulfide reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+." [EC:1.8.1.7, ISBN:0198506732] comment: Note that this function was formerly EC:1.6.4.2. subset: gosubset_prok synonym: "glutathione reductase (NADPH) activity" EXACT [] synonym: "glutathione reductase activity" EXACT [] synonym: "glutathione S-reductase activity" EXACT [EC:1.8.1.7] synonym: "glutathione-disulphide reductase activity" EXACT [] synonym: "glutathione:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.7] synonym: "GSH reductase activity" EXACT [EC:1.8.1.7] synonym: "GSSG reductase activity" EXACT [EC:1.8.1.7] synonym: "NADPH-glutathione reductase activity" EXACT [EC:1.8.1.7] synonym: "NADPH-GSSG reductase activity" EXACT [EC:1.8.1.7] synonym: "NADPH:oxidized-glutathione oxidoreductase activity" EXACT [EC:1.8.1.7] synonym: "oxidized glutathione reduction" RELATED [] xref: EC:1.8.1.7 xref: MetaCyc:GLUTATHIONE-REDUCT-NADPH-RXN xref: Reactome:REACT_100755 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Plasmodium falciparum" xref: Reactome:REACT_105351 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Mus musculus" xref: Reactome:REACT_106052 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Escherichia coli" xref: Reactome:REACT_107331 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Bos taurus" xref: Reactome:REACT_108894 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Xenopus tropicalis" xref: Reactome:REACT_2220 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Homo sapiens" xref: Reactome:REACT_31135 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Canis familiaris" xref: Reactome:REACT_33636 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Sus scrofa" xref: Reactome:REACT_34766 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Dictyostelium discoideum" xref: Reactome:REACT_82516 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Rattus norvegicus" xref: Reactome:REACT_87466 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Mycobacterium tuberculosis" xref: Reactome:REACT_91212 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Schizosaccharomyces pombe" xref: Reactome:REACT_91373 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Danio rerio" xref: Reactome:REACT_93897 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Caenorhabditis elegans" xref: Reactome:REACT_95299 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Saccharomyces cerevisiae" xref: Reactome:REACT_95410 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Gallus gallus" xref: Reactome:REACT_98360 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+, Taeniopygia guttata" xref: RHEA:11743 is_a: GO:0015038 ! glutathione disulfide oxidoreductase activity is_a: GO:0016209 ! antioxidant activity is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004363 name: glutathione synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate." [EC:6.3.2.3, RHEA:13560] subset: gosubset_prok synonym: "gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)" EXACT [EC:6.3.2.3] synonym: "glutathione synthetase activity" EXACT [EC:6.3.2.3] synonym: "GSH synthetase activity" EXACT [EC:6.3.2.3] xref: EC:6.3.2.3 xref: KEGG:R00497 xref: MetaCyc:GLUTATHIONE-SYN-RXN xref: Reactome:REACT_100394 "gamma-glutamylcysteine combines with glycine to form glutathione, Caenorhabditis elegans" xref: Reactome:REACT_104397 "gamma-glutamylcysteine combines with glycine to form glutathione, Saccharomyces cerevisiae" xref: Reactome:REACT_105605 "gamma-glutamylcysteine combines with glycine to form glutathione, Bos taurus" xref: Reactome:REACT_105891 "gamma-glutamylcysteine combines with glycine to form glutathione, Taeniopygia guttata" xref: Reactome:REACT_108106 "gamma-glutamylcysteine combines with glycine to form glutathione, Sus scrofa" xref: Reactome:REACT_108848 "gamma-glutamylcysteine combines with glycine to form glutathione, Rattus norvegicus" xref: Reactome:REACT_6886 "gamma-glutamylcysteine combines with glycine to form glutathione, Homo sapiens" xref: Reactome:REACT_80709 "gamma-glutamylcysteine combines with glycine to form glutathione, Arabidopsis thaliana" xref: Reactome:REACT_81099 "gamma-glutamylcysteine combines with glycine to form glutathione, Canis familiaris" xref: Reactome:REACT_82957 "gamma-glutamylcysteine combines with glycine to form glutathione, Drosophila melanogaster" xref: Reactome:REACT_84994 "gamma-glutamylcysteine combines with glycine to form glutathione, Mus musculus" xref: Reactome:REACT_86625 "gamma-glutamylcysteine combines with glycine to form glutathione, Schizosaccharomyces pombe" xref: Reactome:REACT_86921 "gamma-glutamylcysteine combines with glycine to form glutathione, Oryza sativa" xref: Reactome:REACT_87951 "gamma-glutamylcysteine combines with glycine to form glutathione, Xenopus tropicalis" xref: Reactome:REACT_90100 "gamma-glutamylcysteine combines with glycine to form glutathione, Dictyostelium discoideum" xref: Reactome:REACT_93797 "gamma-glutamylcysteine combines with glycine to form glutathione, Gallus gallus" xref: Reactome:REACT_99493 "gamma-glutamylcysteine combines with glycine to form glutathione, Danio rerio" xref: Reactome:REACT_99980 "gamma-glutamylcysteine combines with glycine to form glutathione, Plasmodium falciparum" xref: RHEA:13560 is_a: GO:0016881 ! acid-amino acid ligase activity relationship: part_of GO:0006750 ! glutathione biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004364 name: glutathione transferase activity namespace: molecular_function def: "Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18] subset: gosubset_prok synonym: "glutathione conjugation reaction" EXACT [] synonym: "glutathione S-alkyl transferase activity" EXACT [EC:2.5.1.18] synonym: "glutathione S-alkyltransferase activity" EXACT [EC:2.5.1.18] synonym: "glutathione S-aralkyltransferase activity" EXACT [EC:2.5.1.18] synonym: "glutathione S-aryltransferase activity" EXACT [EC:2.5.1.18] synonym: "glutathione S-transferase activity" EXACT [EC:2.5.1.18] synonym: "RX:glutathione R-transferase activity" EXACT [EC:2.5.1.18] synonym: "S-(hydroxyalkyl)glutathione lyase activity" EXACT [EC:2.5.1.18] xref: EC:2.5.1.18 xref: MetaCyc:GSHTRAN-RXN xref: Reactome:REACT_100785 "Glutathione conjugation of luminal substrates, Oryza sativa" xref: Reactome:REACT_101029 "Glutathione conjugation of luminal substrates, Canis familiaris" xref: Reactome:REACT_108390 "Glutathione conjugation of luminal substrates, Gallus gallus" xref: Reactome:REACT_110631 "Glutathione conjugation of luminal substrates, Xenopus tropicalis" xref: Reactome:REACT_113981 "Glutathione conjugation of cytosolic substrates, Oryza sativa" xref: Reactome:REACT_114178 "Glutathione conjugation of luminal substrates, Plasmodium falciparum" xref: Reactome:REACT_114437 "Glutathione conjugation of cytosolic substrates, Arabidopsis thaliana" xref: Reactome:REACT_114776 "Glutathione conjugation of cytosolic substrates, Plasmodium falciparum" xref: Reactome:REACT_30282 "Glutathione conjugation of cytosolic substrates, Canis familiaris" xref: Reactome:REACT_32347 "Glutathione conjugation of cytosolic substrates, Sus scrofa" xref: Reactome:REACT_6854 "Glutathione conjugation of cytosolic substrates, Homo sapiens" xref: Reactome:REACT_6947 "Glutathione conjugation of luminal substrates, Homo sapiens" xref: Reactome:REACT_78100 "Glutathione conjugation of cytosolic substrates, Caenorhabditis elegans" xref: Reactome:REACT_78483 "Glutathione conjugation of cytosolic substrates, Gallus gallus" xref: Reactome:REACT_80590 "Glutathione conjugation of cytosolic substrates, Taeniopygia guttata" xref: Reactome:REACT_83452 "Glutathione conjugation of luminal substrates, Sus scrofa" xref: Reactome:REACT_84786 "Glutathione conjugation of cytosolic substrates, Danio rerio" xref: Reactome:REACT_84896 "Glutathione conjugation of cytosolic substrates, Xenopus tropicalis" xref: Reactome:REACT_85283 "Glutathione conjugation of cytosolic substrates, Mus musculus" xref: Reactome:REACT_85369 "Glutathione conjugation of cytosolic substrates, Rattus norvegicus" xref: Reactome:REACT_87985 "Glutathione conjugation of luminal substrates, Bos taurus" xref: Reactome:REACT_89910 "Glutathione conjugation of cytosolic substrates, Drosophila melanogaster" xref: Reactome:REACT_92411 "Glutathione conjugation of luminal substrates, Arabidopsis thaliana" xref: Reactome:REACT_93234 "Glutathione conjugation of luminal substrates, Rattus norvegicus" xref: Reactome:REACT_93830 "Glutathione conjugation of luminal substrates, Danio rerio" xref: Reactome:REACT_94550 "Glutathione conjugation of cytosolic substrates, Bos taurus" xref: Reactome:REACT_97954 "Glutathione conjugation of luminal substrates, Mus musculus" xref: Reactome:REACT_98524 "Glutathione conjugation of luminal substrates, Drosophila melanogaster" xref: Reactome:REACT_99142 "Glutathione conjugation of luminal substrates, Taeniopygia guttata" is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004382 name: guanosine-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: GDP + H2O = GMP + phosphate." [EC:3.6.1.42, PMID:2989286] synonym: "GDP phosphohydrolase activity" EXACT [EC:3.6.1.42] synonym: "GDPase activity" EXACT [EC:3.6.1.42] synonym: "guanosine 5'-diphosphatase activity" EXACT [EC:3.6.1.6] synonym: "guanosine diphosphatase activity" EXACT [] xref: EC:3.6.1.42 xref: MetaCyc:GUANOSINE-DIPHOSPHATASE-RXN xref: RHEA:22159 is_a: GO:0017110 ! nucleoside-diphosphatase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004386 name: helicase activity namespace: molecular_function def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] comment: Note that most helicases catalyze processive duplex unwinding. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast subset: gosubset_prok xref: Reactome:REACT_101111 "Addition of the third nucleotide on the nascent transcript, Saccharomyces cerevisiae" xref: Reactome:REACT_101247 "Formation of open bubble structure in DNA by helicases, Bos taurus" xref: Reactome:REACT_101622 "MCM8 mediated fork unwinding, Danio rerio" xref: Reactome:REACT_101644 "Formation of open bubble structure in DNA by helicases, Oryza sativa" xref: Reactome:REACT_101823 "MCM2-7 mediated fork unwinding, Plasmodium falciparum" xref: Reactome:REACT_101994 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Xenopus tropicalis" xref: Reactome:REACT_102121 "Addition of the third nucleotide on the nascent transcript, Rattus norvegicus" xref: Reactome:REACT_102441 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Gallus gallus" xref: Reactome:REACT_102560 "MCM2-7 mediated fork unwinding, Oryza sativa" xref: Reactome:REACT_1033 "Formation of open bubble structure in DNA by helicases, Homo sapiens" xref: Reactome:REACT_103861 "MCM8 mediated fork unwinding, Bos taurus" xref: Reactome:REACT_103881 "RNA Polymerase II Promoter Opening: First Transition, Dictyostelium discoideum" xref: Reactome:REACT_103897 "MCM8 mediated fork unwinding, Mus musculus" xref: Reactome:REACT_103959 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Rattus norvegicus" xref: Reactome:REACT_104221 "MCM2-7 mediated fork unwinding, Rattus norvegicus" xref: Reactome:REACT_105950 "MCM2-7 mediated fork unwinding, Xenopus tropicalis" xref: Reactome:REACT_106346 "Formation of open bubble structure in DNA by helicases, Taeniopygia guttata" xref: Reactome:REACT_107072 "Formation of open bubble structure in DNA by helicases, Mus musculus" xref: Reactome:REACT_107495 "RNA Polymerase II Promoter Opening: First Transition, Taeniopygia guttata" xref: Reactome:REACT_108159 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Dictyostelium discoideum" xref: Reactome:REACT_108648 "Addition of the third nucleotide on the nascent transcript, Arabidopsis thaliana" xref: Reactome:REACT_108654 "MCM2-7 mediated fork unwinding, Schizosaccharomyces pombe" xref: Reactome:REACT_109035 "RNA Polymerase II Promoter Opening: First Transition, Schizosaccharomyces pombe" xref: Reactome:REACT_109161 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Arabidopsis thaliana" xref: Reactome:REACT_110588 "MCM8 mediated fork unwinding, Xenopus tropicalis" xref: Reactome:REACT_110827 "Formation of open bubble structure in DNA by helicases, Danio rerio" xref: Reactome:REACT_110845 "Cap-bound mRNA is activated by helicases, Mus musculus" xref: Reactome:REACT_112208 "MCM8 mediated fork unwinding, Drosophila melanogaster" xref: Reactome:REACT_112817 "Cap-bound mRNA is activated by helicases, Schizosaccharomyces pombe" xref: Reactome:REACT_113177 "Formation of open bubble structure in DNA by helicases, Caenorhabditis elegans" xref: Reactome:REACT_1521 "Cap-bound mRNA is activated by helicases, Homo sapiens" xref: Reactome:REACT_1817 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Homo sapiens" xref: Reactome:REACT_1844 "RNA Polymerase II Promoter Opening: First Transition, Homo sapiens" xref: Reactome:REACT_28131 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Drosophila melanogaster" xref: Reactome:REACT_28343 "MCM2-7 mediated fork unwinding, Danio rerio" xref: Reactome:REACT_28810 "Addition of the third nucleotide on the nascent transcript, Oryza sativa" xref: Reactome:REACT_28880 "MCM2-7 mediated fork unwinding, Drosophila melanogaster" xref: Reactome:REACT_29155 "Addition of the third nucleotide on the nascent transcript, Drosophila melanogaster" xref: Reactome:REACT_29217 "Formation of open bubble structure in DNA by helicases, Xenopus tropicalis" xref: Reactome:REACT_29818 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Oryza sativa" xref: Reactome:REACT_29850 "RNA Polymerase II Promoter Opening: First Transition, Saccharomyces cerevisiae" xref: Reactome:REACT_30013 "MCM8 mediated fork unwinding, Rattus norvegicus" xref: Reactome:REACT_30989 "MCM8 mediated fork unwinding, Arabidopsis thaliana" xref: Reactome:REACT_31034 "Cap-bound mRNA is activated by helicases, Danio rerio" xref: Reactome:REACT_31090 "MCM2-7 mediated fork unwinding, Gallus gallus" xref: Reactome:REACT_31554 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Schizosaccharomyces pombe" xref: Reactome:REACT_32533 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Caenorhabditis elegans" xref: Reactome:REACT_33205 "MCM8 mediated fork unwinding, Canis familiaris" xref: Reactome:REACT_34016 "Formation of open bubble structure in DNA by helicases, Rattus norvegicus" xref: Reactome:REACT_34089 "MCM2-7 mediated fork unwinding, Dictyostelium discoideum" xref: Reactome:REACT_34560 "MCM8 mediated fork unwinding, Sus scrofa" xref: Reactome:REACT_40 "Addition of the third nucleotide on the nascent transcript, Homo sapiens" xref: Reactome:REACT_6134 "HIV-1 Promoter Opening: First Transition, Homo sapiens" xref: Reactome:REACT_6184 "Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition, Homo sapiens" xref: Reactome:REACT_6325 "Addition of the third nucleotide on the nascent HIV-1 transcript, Homo sapiens" xref: Reactome:REACT_6758 "Xenopus Mcm8 mediated fork unwinding, Xenopus laevis" xref: Reactome:REACT_6768 "MCM8 mediated fork unwinding, Homo sapiens" xref: Reactome:REACT_6853 "Yeast Mcm2-7 mediated fork unwinding, Saccharomyces cerevisiae" xref: Reactome:REACT_6922 "MCM2-7 mediated fork unwinding, Homo sapiens" xref: Reactome:REACT_78086 "RNA Polymerase II Promoter Opening: First Transition, Rattus norvegicus" xref: Reactome:REACT_78462 "Formation of open bubble structure in DNA by helicases, Drosophila melanogaster" xref: Reactome:REACT_78667 "MCM2-7 mediated fork unwinding, Canis familiaris" xref: Reactome:REACT_78771 "MCM8 mediated fork unwinding, Dictyostelium discoideum" xref: Reactome:REACT_79759 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Mus musculus" xref: Reactome:REACT_80107 "RNA Polymerase II Promoter Opening: First Transition, Arabidopsis thaliana" xref: Reactome:REACT_80325 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Danio rerio" xref: Reactome:REACT_80500 "MCM8 mediated fork unwinding, Gallus gallus" xref: Reactome:REACT_80532 "Addition of the third nucleotide on the nascent transcript, Gallus gallus" xref: Reactome:REACT_80605 "Addition of the third nucleotide on the nascent transcript, Mus musculus" xref: Reactome:REACT_81126 "Addition of the third nucleotide on the nascent transcript, Schizosaccharomyces pombe" xref: Reactome:REACT_81335 "RNA Polymerase II Promoter Opening: First Transition, Gallus gallus" xref: Reactome:REACT_81427 "MCM8 mediated fork unwinding, Taeniopygia guttata" xref: Reactome:REACT_81441 "MCM8 mediated fork unwinding, Oryza sativa" xref: Reactome:REACT_81682 "Formation of open bubble structure in DNA by helicases, Canis familiaris" xref: Reactome:REACT_82776 "RNA Polymerase II Promoter Opening: First Transition, Danio rerio" xref: Reactome:REACT_83794 "Formation of open bubble structure in DNA by helicases, Gallus gallus" xref: Reactome:REACT_84565 "Formation of open bubble structure in DNA by helicases, Schizosaccharomyces pombe" xref: Reactome:REACT_84574 "Cap-bound mRNA is activated by helicases, Canis familiaris" xref: Reactome:REACT_84809 "MCM2-7 mediated fork unwinding, Mus musculus" xref: Reactome:REACT_84907 "MCM2-7 mediated fork unwinding, Taeniopygia guttata" xref: Reactome:REACT_85111 "Cap-bound mRNA is activated by helicases, Drosophila melanogaster" xref: Reactome:REACT_85172 "MCM2-7 mediated fork unwinding, Arabidopsis thaliana" xref: Reactome:REACT_86220 "MCM2-7 mediated fork unwinding, Caenorhabditis elegans" xref: Reactome:REACT_88362 "Addition of the third nucleotide on the nascent transcript, Caenorhabditis elegans" xref: Reactome:REACT_89000 "MCM2-7 mediated fork unwinding, Bos taurus" xref: Reactome:REACT_89030 "Formation of open bubble structure in DNA by helicases, Saccharomyces cerevisiae" xref: Reactome:REACT_89363 "Addition of the third nucleotide on the nascent transcript, Xenopus tropicalis" xref: Reactome:REACT_89694 "RNA Polymerase II Promoter Opening: First Transition, Drosophila melanogaster" xref: Reactome:REACT_91822 "MCM8 mediated fork unwinding, Plasmodium falciparum" xref: Reactome:REACT_93391 "RNA Polymerase II Promoter Opening: First Transition, Oryza sativa" xref: Reactome:REACT_93711 "RNA Polymerase II Promoter Opening: First Transition, Mus musculus" xref: Reactome:REACT_94645 "RNA Polymerase II Promoter Opening: First Transition, Xenopus tropicalis" xref: Reactome:REACT_94679 "RNA Polymerase II Promoter Opening: First Transition, Caenorhabditis elegans" xref: Reactome:REACT_95942 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition, Saccharomyces cerevisiae" xref: Reactome:REACT_95993 "Formation of open bubble structure in DNA by helicases, Arabidopsis thaliana" xref: Reactome:REACT_98273 "Addition of the third nucleotide on the nascent transcript, Dictyostelium discoideum" xref: Reactome:REACT_98302 "Formation of open bubble structure in DNA by helicases, Sus scrofa" xref: Reactome:REACT_98745 "Cap-bound mRNA is activated by helicases, Xenopus tropicalis" xref: Reactome:REACT_99120 "Addition of the third nucleotide on the nascent transcript, Danio rerio" is_a: GO:0017111 ! nucleoside-triphosphatase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004407 name: histone deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes." [EC:3.5.1.98, PMID:9893272] xref: EC:3.5.1.98 xref: MetaCyc:3.5.1.98-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0033558 ! protein deacetylase activity relationship: part_of GO:0016575 ! histone deacetylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004410 name: homocitrate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H(2)O = CoA + H(+) + homocitrate." [EC:2.3.3.14, RHEA:12932] comment: Note that this function was formerly EC:4.1.3.21. subset: gosubset_prok synonym: "2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating) activity" EXACT [EC:2.3.3.14] synonym: "2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating)" EXACT [EC:2.3.3.14] synonym: "acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)" EXACT [EC:2.3.3.14] synonym: "acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase activity" EXACT [EC:2.3.3.14] synonym: "homocitrate synthetase activity" EXACT [EC:2.3.3.14] xref: EC:2.3.3.14 xref: KEGG:R00271 xref: MetaCyc:HOMOCITRATE-SYNTHASE-RXN xref: RHEA:12932 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004420 name: hydroxymethylglutaryl-CoA reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH." [EC:1.1.1.34, RHEA:15992] subset: gosubset_prok synonym: "3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [EC:1.1.1.34] synonym: "HMG-CoA reductase activity" BROAD [EC:1.1.1.34] xref: EC:1.1.1.34 xref: KEGG:R02082 xref: MetaCyc:1.1.1.34-RXN xref: Reactome:REACT_100813 "Reduction of HMG-CoA produces mevalonate, Arabidopsis thaliana" xref: Reactome:REACT_103521 "Reduction of HMG-CoA produces mevalonate, Caenorhabditis elegans" xref: Reactome:REACT_103848 "Reduction of HMG-CoA produces mevalonate, Saccharomyces cerevisiae" xref: Reactome:REACT_105607 "Reduction of HMG-CoA produces mevalonate, Gallus gallus" xref: Reactome:REACT_106886 "Reduction of HMG-CoA produces mevalonate, Bos taurus" xref: Reactome:REACT_109306 "Reduction of HMG-CoA produces mevalonate, Dictyostelium discoideum" xref: Reactome:REACT_111022 "Reduction of HMG-CoA produces mevalonate, Drosophila melanogaster" xref: Reactome:REACT_29404 "Reduction of HMG-CoA produces mevalonate, Canis familiaris" xref: Reactome:REACT_30181 "Reduction of HMG-CoA produces mevalonate, Taeniopygia guttata" xref: Reactome:REACT_80613 "Reduction of HMG-CoA produces mevalonate, Mus musculus" xref: Reactome:REACT_85139 "Reduction of HMG-CoA produces mevalonate, Xenopus tropicalis" xref: Reactome:REACT_89068 "Reduction of HMG-CoA produces mevalonate, Schizosaccharomyces pombe" xref: Reactome:REACT_91015 "Reduction of HMG-CoA produces mevalonate, Oryza sativa" xref: Reactome:REACT_91582 "Reduction of HMG-CoA produces mevalonate, Danio rerio" xref: Reactome:REACT_9482 "Reduction of HMG-CoA produces mevalonate, Homo sapiens" xref: Reactome:REACT_97829 "Reduction of HMG-CoA produces mevalonate, Sus scrofa" xref: Reactome:REACT_99024 "Reduction of HMG-CoA produces mevalonate, Rattus norvegicus" xref: RHEA:15992 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004448 name: isocitrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: isocitrate + acceptor = 2-oxoglutarate + CO2 + reduced acceptor." [EC:1.1.1.41, EC:1.1.1.42] subset: gosubset_prok synonym: "beta-ketoglutaric-isocitric carboxylase activity" EXACT [EC:1.1.1.-] synonym: "IDH activity" EXACT [EC:1.1.1.-] synonym: "IDP activity" EXACT [EC:1.1.1.-] synonym: "IDP1" RELATED [EC:1.1.1.-] synonym: "IDP2" RELATED [EC:1.1.1.-] synonym: "IDP3" RELATED [EC:1.1.1.-] synonym: "isocitric acid dehydrogenase activity" EXACT [EC:1.1.1.-] synonym: "isocitric dehydrogenase activity" EXACT [EC:1.1.1.-] synonym: "oxalosuccinate carboxylase activity" EXACT [EC:1.1.1.-] synonym: "oxalosuccinate decarboxylase activity" EXACT [EC:1.1.1.-] synonym: "oxalsuccinic decarboxylase activity" EXACT [EC:1.1.1.-] xref: EC:1.1.1.- xref: MetaCyc:ISOCITDEH-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004449 name: isocitrate dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+." [EC:1.1.1.41] subset: gosubset_prok synonym: "isocitrate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.41] synonym: "isocitrate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.41] synonym: "NAD dependent isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] synonym: "NAD isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] synonym: "NAD isocitric dehydrogenase activity" EXACT [EC:1.1.1.41] synonym: "NAD-linked isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] synonym: "NAD-specific isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] synonym: "nicotinamide adenine dinucleotide isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] xref: EC:1.1.1.41 xref: MetaCyc:ISOCITRATE-DEHYDROGENASE-NAD+-RXN xref: Reactome:REACT_103757 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3], Xenopus tropicalis" xref: Reactome:REACT_104411 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3], Mus musculus" xref: Reactome:REACT_105047 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3], Caenorhabditis elegans" xref: Reactome:REACT_1068 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3], Homo sapiens" xref: Reactome:REACT_112010 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3], Bos taurus" xref: Reactome:REACT_113241 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3], Canis familiaris" xref: Reactome:REACT_115988 "isocitrate + NAD+ => 2-oxoglutarate (alpha-ketoglutarate) + CO2 + NADH + H+, Gallus gallus" xref: Reactome:REACT_33751 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3], Dictyostelium discoideum" xref: Reactome:REACT_34198 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3], Arabidopsis thaliana" xref: Reactome:REACT_34664 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3], Danio rerio" xref: Reactome:REACT_78963 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3], Drosophila melanogaster" xref: Reactome:REACT_81678 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3], Oryza sativa" xref: Reactome:REACT_86659 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3], Schizosaccharomyces pombe" xref: Reactome:REACT_90578 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3], Saccharomyces cerevisiae" xref: Reactome:REACT_91953 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3], Rattus norvegicus" xref: Reactome:REACT_98704 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3], Sus scrofa" xref: RHEA:23635 is_a: GO:0004448 ! isocitrate dehydrogenase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004467 name: long-chain fatty acid-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, EC:6.2.1.3] subset: gosubset_prok synonym: "ACS3" NARROW [EC:6.2.1.3] synonym: "acyl-activating enzyme activity" BROAD [EC:6.2.1.3] synonym: "acyl-CoA synthetase activity" EXACT [EC:6.2.1.3] synonym: "arachidonyl-CoA synthetase" NARROW [EC:6.2.1.3] synonym: "FAA1" NARROW [EC:6.2.1.3] synonym: "fatty acid thiokinase (long chain) activity" EXACT [EC:6.2.1.3] synonym: "fatty acid thiokinase (long-chain) activity" EXACT [EC:6.2.1.3] synonym: "LCFA synthetase activity" EXACT [EC:6.2.1.3] synonym: "lignoceroyl-CoA synthase activity" EXACT [EC:6.2.1.3] synonym: "long chain fatty acyl-CoA synthetase activity" EXACT [EC:6.2.1.3] synonym: "long-chain acyl CoA synthetase activity" EXACT [EC:6.2.1.3] synonym: "long-chain acyl-CoA synthetase activity" EXACT [] synonym: "long-chain acyl-CoA synthetase I" NARROW [EC:6.2.1.3] synonym: "long-chain acyl-CoA synthetase II" NARROW [EC:6.2.1.3] synonym: "long-chain acyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.3] synonym: "long-chain fatty acid activation" RELATED [] synonym: "long-chain fatty acyl coenzyme A synthetase activity" EXACT [EC:6.2.1.3] synonym: "long-chain-fatty-acid-CoA ligase activity" EXACT [] synonym: "long-chain-fatty-acyl-CoA synthetase activity" EXACT [] synonym: "oleoyl-CoA synthetase" NARROW [EC:6.2.1.3] synonym: "palmitoyl coenzyme A synthetase" NARROW [EC:6.2.1.3] synonym: "palmitoyl-CoA ligase" NARROW [EC:6.2.1.3] synonym: "palmitoyl-CoA synthase" NARROW [EC:6.2.1.3] synonym: "pristanoyl-CoA synthetase" NARROW [EC:6.2.1.3] synonym: "stearoyl-CoA synthetase" NARROW [EC:6.2.1.3] synonym: "thiokinase" RELATED [EC:6.2.1.3] xref: EC:6.2.1.3 xref: MetaCyc:ACYLCOASYN-RXN xref: MetaCyc:PWY-5143 xref: Reactome:REACT_10000 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS), Homo sapiens" xref: Reactome:REACT_100146 "THCA is conjugated with Coenzyme A (SLC27A5 BACS), Danio rerio" xref: Reactome:REACT_10020 "THCA is conjugated with Coenzyme A (SLC27A5 BACS), Homo sapiens" xref: Reactome:REACT_10034 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS), Homo sapiens" xref: Reactome:REACT_100377 "THCA is conjugated with Coenzyme A (SLC27A5 BACS), Bos taurus" xref: Reactome:REACT_10049 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Homo sapiens" xref: Reactome:REACT_10064 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS), Homo sapiens" xref: Reactome:REACT_10087 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS), Homo sapiens" xref: Reactome:REACT_10106 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Homo sapiens" xref: Reactome:REACT_10119 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Homo sapiens" xref: Reactome:REACT_101550 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS), Gallus gallus" xref: Reactome:REACT_102048 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Bos taurus" xref: Reactome:REACT_102674 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Danio rerio" xref: Reactome:REACT_102719 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS), Taeniopygia guttata" xref: Reactome:REACT_102779 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Gallus gallus" xref: Reactome:REACT_103147 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1], Canis familiaris" xref: Reactome:REACT_103154 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Canis familiaris" xref: Reactome:REACT_103348 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS), Rattus norvegicus" xref: Reactome:REACT_104228 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS), Mus musculus" xref: Reactome:REACT_104748 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Xenopus tropicalis" xref: Reactome:REACT_105072 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Taeniopygia guttata" xref: Reactome:REACT_105167 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS), Rattus norvegicus" xref: Reactome:REACT_105842 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Gallus gallus" xref: Reactome:REACT_106315 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS), Taeniopygia guttata" xref: Reactome:REACT_106400 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Xenopus tropicalis" xref: Reactome:REACT_106582 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Bos taurus" xref: Reactome:REACT_107010 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Bos taurus" xref: Reactome:REACT_107065 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Mus musculus" xref: Reactome:REACT_107825 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS), Gallus gallus" xref: Reactome:REACT_108040 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Drosophila melanogaster" xref: Reactome:REACT_108152 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Mus musculus" xref: Reactome:REACT_108327 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Bos taurus" xref: Reactome:REACT_108413 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Arabidopsis thaliana" xref: Reactome:REACT_109181 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS), Rattus norvegicus" xref: Reactome:REACT_109281 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Oryza sativa" xref: Reactome:REACT_109377 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS), Canis familiaris" xref: Reactome:REACT_109580 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Taeniopygia guttata" xref: Reactome:REACT_110284 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS), Taeniopygia guttata" xref: Reactome:REACT_110400 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Mycobacterium tuberculosis" xref: Reactome:REACT_110600 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS), Bos taurus" xref: Reactome:REACT_110635 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Bos taurus" xref: Reactome:REACT_11137 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1], Homo sapiens" xref: Reactome:REACT_112002 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS), Saccharomyces cerevisiae" xref: Reactome:REACT_112185 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Dictyostelium discoideum" xref: Reactome:REACT_112197 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Mycobacterium tuberculosis" xref: Reactome:REACT_112234 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Dictyostelium discoideum" xref: Reactome:REACT_112314 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Taeniopygia guttata" xref: Reactome:REACT_112696 "THCA is conjugated with Coenzyme A (SLC27A5 BACS), Saccharomyces cerevisiae" xref: Reactome:REACT_113165 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Saccharomyces cerevisiae" xref: Reactome:REACT_113283 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Saccharomyces cerevisiae" xref: Reactome:REACT_113402 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Taeniopygia guttata" xref: Reactome:REACT_113433 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Plasmodium falciparum" xref: Reactome:REACT_113477 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS), Saccharomyces cerevisiae" xref: Reactome:REACT_113562 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS), Saccharomyces cerevisiae" xref: Reactome:REACT_113604 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Taeniopygia guttata" xref: Reactome:REACT_114408 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Saccharomyces cerevisiae" xref: Reactome:REACT_114641 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS), Saccharomyces cerevisiae" xref: Reactome:REACT_114941 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Saccharomyces cerevisiae" xref: Reactome:REACT_115449 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Taeniopygia guttata" xref: Reactome:REACT_115464 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Xenopus tropicalis" xref: Reactome:REACT_22247 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL6], Homo sapiens" xref: Reactome:REACT_22376 "arachidonate + CoASH + ATP => arachidonoyl-CoA + AMP + pyrophosphate + H2O [ACSL4], Homo sapiens" xref: Reactome:REACT_22410 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Homo sapiens" xref: Reactome:REACT_28244 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Danio rerio" xref: Reactome:REACT_28477 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Rattus norvegicus" xref: Reactome:REACT_28700 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Rattus norvegicus" xref: Reactome:REACT_29173 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS), Canis familiaris" xref: Reactome:REACT_30197 "THCA is conjugated with Coenzyme A (SLC27A5 BACS), Canis familiaris" xref: Reactome:REACT_30265 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Mycobacterium tuberculosis" xref: Reactome:REACT_32832 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Mycobacterium tuberculosis" xref: Reactome:REACT_33155 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Sus scrofa" xref: Reactome:REACT_33243 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS), Mus musculus" xref: Reactome:REACT_34606 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Xenopus tropicalis" xref: Reactome:REACT_34728 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1], Gallus gallus" xref: Reactome:REACT_77878 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Mus musculus" xref: Reactome:REACT_78613 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Danio rerio" xref: Reactome:REACT_79153 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS), Danio rerio" xref: Reactome:REACT_79206 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Mus musculus" xref: Reactome:REACT_79554 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1], Danio rerio" xref: Reactome:REACT_79937 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1], Bos taurus" xref: Reactome:REACT_80135 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Canis familiaris" xref: Reactome:REACT_80410 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Sus scrofa" xref: Reactome:REACT_80584 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS), Mus musculus" xref: Reactome:REACT_82148 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS), Bos taurus" xref: Reactome:REACT_82230 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Saccharomyces cerevisiae" xref: Reactome:REACT_82547 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1], Xenopus tropicalis" xref: Reactome:REACT_83689 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1], Rattus norvegicus" xref: Reactome:REACT_83959 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Caenorhabditis elegans" xref: Reactome:REACT_84131 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Canis familiaris" xref: Reactome:REACT_84943 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Rattus norvegicus" xref: Reactome:REACT_85114 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS), Rattus norvegicus" xref: Reactome:REACT_85507 "THCA is conjugated with Coenzyme A (SLC27A5 BACS), Rattus norvegicus" xref: Reactome:REACT_86419 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS), Canis familiaris" xref: Reactome:REACT_86526 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS), Mycobacterium tuberculosis" xref: Reactome:REACT_86586 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS), Mycobacterium tuberculosis" xref: Reactome:REACT_86823 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1], Taeniopygia guttata" xref: Reactome:REACT_86910 "THCA is conjugated with Coenzyme A (SLC27A5 BACS), Mycobacterium tuberculosis" xref: Reactome:REACT_87364 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS), Bos taurus" xref: Reactome:REACT_87672 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Schizosaccharomyces pombe" xref: Reactome:REACT_87771 "THCA is conjugated with Coenzyme A (SLC27A5 BACS), Gallus gallus" xref: Reactome:REACT_88190 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS), Danio rerio" xref: Reactome:REACT_88276 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS), Bos taurus" xref: Reactome:REACT_88286 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Sus scrofa" xref: Reactome:REACT_88806 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Danio rerio" xref: Reactome:REACT_89212 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Rattus norvegicus" xref: Reactome:REACT_89373 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Mus musculus" xref: Reactome:REACT_89406 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS), Mus musculus" xref: Reactome:REACT_89639 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Mycobacterium tuberculosis" xref: Reactome:REACT_89817 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Rattus norvegicus" xref: Reactome:REACT_89907 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS), Taeniopygia guttata" xref: Reactome:REACT_89914 "THCA is conjugated with Coenzyme A (SLC27A5 BACS), Taeniopygia guttata" xref: Reactome:REACT_90120 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS), Mycobacterium tuberculosis" xref: Reactome:REACT_90313 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Sus scrofa" xref: Reactome:REACT_91245 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Canis familiaris" xref: Reactome:REACT_91297 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Mus musculus" xref: Reactome:REACT_91342 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Canis familiaris" xref: Reactome:REACT_91481 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS), Gallus gallus" xref: Reactome:REACT_92094 "THCA is conjugated with Coenzyme A (SLC27A5 BACS), Mus musculus" xref: Reactome:REACT_92380 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Caenorhabditis elegans" xref: Reactome:REACT_930 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Homo sapiens" xref: Reactome:REACT_94093 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1], Mus musculus" xref: Reactome:REACT_94281 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Rattus norvegicus" xref: Reactome:REACT_95456 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS), Mycobacterium tuberculosis" xref: Reactome:REACT_96062 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Sus scrofa" xref: Reactome:REACT_96718 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Xenopus tropicalis" xref: Reactome:REACT_97075 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Sus scrofa" xref: Reactome:REACT_97472 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL5], Canis familiaris" xref: Reactome:REACT_97742 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL1], Sus scrofa" xref: Reactome:REACT_97937 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS), Gallus gallus" xref: Reactome:REACT_98426 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS), Danio rerio" xref: Reactome:REACT_98486 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Bos taurus" xref: Reactome:REACT_98598 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS), Danio rerio" xref: Reactome:REACT_98628 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Danio rerio" xref: Reactome:REACT_98739 "palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O [ACSL3], Danio rerio" xref: Reactome:REACT_98845 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS), Xenopus tropicalis" xref: Reactome:REACT_99260 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS), Canis familiaris" xref: Reactome:REACT_9970 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS), Homo sapiens" xref: UM-BBD_enzymeID:e0025 is_a: GO:0015645 ! fatty acid ligase activity relationship: part_of GO:0001676 ! long-chain fatty acid metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004470 name: malic enzyme activity namespace: molecular_function def: "Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate." [ISBN:0198506732] subset: gosubset_prok synonym: "pyruvic-malic carboxylase activity" EXACT [EC:1.1.1.39] is_a: GO:0016615 ! malate dehydrogenase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004471 name: malate dehydrogenase (decarboxylating) (NAD+) activity namespace: molecular_function alt_id: GO:0004472 alt_id: GO:0016619 def: "Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+." [EC:1.1.1.38, EC:1.1.1.39] comment: For decarboxylation of oxaloacetate (the second substrate listed in EC:1.1.1.38), see 'oxaloacetate decarboxylase activity ; GO:0008948'. subset: gosubset_prok synonym: "'malic' enzyme" RELATED [EC:1.1.1.38, EC:1.1.1.39] synonym: "(S)-malate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.39] synonym: "(S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [EC:1.1.1.38] synonym: "malate dehydrogenase (decarboxylating) activity" EXACT [EC:1.1.1.39] synonym: "malate dehydrogenase (oxaloacetate-decarboxylating) activity" EXACT [] synonym: "NAD-linked malic enzyme" RELATED [EC:1.1.1.38] synonym: "NAD-malic enzyme activity" BROAD [EC:1.1.1.38, EC:1.1.1.39] synonym: "NAD-specific malic enzyme" RELATED [EC:1.1.1.38, EC:1.1.1.39] xref: EC:1.1.1.38 xref: EC:1.1.1.39 xref: KEGG:R00214 xref: MetaCyc:1.1.1.39-RXN xref: MetaCyc:MALIC-NAD-RXN xref: RHEA:12656 is_a: GO:0004470 ! malic enzyme activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004489 name: methylenetetrahydrofolate reductase (NAD(P)H) activity namespace: molecular_function alt_id: GO:0008702 def: "Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+." [EC:1.5.1.20] comment: Includes EC 1.7.99.5. subset: gosubset_prok synonym: "1.7.99.5" RELATED [] synonym: "5,10-CH(2)-H(4)folate reductase activity" EXACT [EC:1.5.1.20] synonym: "5,10-CH2-H4folate reductase activity" EXACT [EC:1.5.1.20] synonym: "5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [EC:1.5.1.20] synonym: "5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [] synonym: "5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [] synonym: "5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [EC:1.5.1.20] synonym: "5,10-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] synonym: "5,10-methylenetetrahydrofolic acid reductase activity" BROAD [EC:1.5.1.20] synonym: "5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "MetF" RELATED [EC:1.5.1.20] synonym: "methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.5.1.20] synonym: "methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [EC:1.5.1.20] synonym: "methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [EC:1.5.1.20] synonym: "methylenetetrahydrofolate reductase (NADPH2)" EXACT [EC:1.5.1.20] synonym: "methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [EC:1.5.1.20] synonym: "methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] synonym: "methylenetetrahydrofolic acid reductase activity" BROAD [EC:1.5.1.20] synonym: "MTHFR activity" BROAD [EC:1.5.1.20] synonym: "N(5),N(10)-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] synonym: "N(5,10)-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] synonym: "N5,10-methylenetetrahydrofolate reductase activity" EXACT [EC:1.5.1.20] synonym: "N5,N10-methylenetetrahydrofolate reductase activity" EXACT [EC:1.5.1.20] xref: EC:1.5.1.20 xref: KEGG:R01224 xref: KEGG:R07168 xref: MetaCyc:1.5.1.20-RXN xref: Reactome:REACT_100929 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+, Sus scrofa" xref: Reactome:REACT_102712 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+, Gallus gallus" xref: Reactome:REACT_106752 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+, Taeniopygia guttata" xref: Reactome:REACT_106770 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+, Dictyostelium discoideum" xref: Reactome:REACT_109034 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+, Xenopus tropicalis" xref: Reactome:REACT_110093 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+, Danio rerio" xref: Reactome:REACT_110152 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+, Mus musculus" xref: Reactome:REACT_11102 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+, Homo sapiens" xref: Reactome:REACT_29352 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+, Rattus norvegicus" xref: Reactome:REACT_30478 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+, Canis familiaris" xref: Reactome:REACT_33585 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+, Escherichia coli" xref: Reactome:REACT_78371 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+, Caenorhabditis elegans" xref: Reactome:REACT_96333 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+, Bos taurus" xref: Reactome:REACT_97871 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+, Oryza sativa" xref: Reactome:REACT_98681 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+, Drosophila melanogaster" xref: RHEA:19820 xref: RHEA:19824 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004518 name: nuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] comment: Note that 'tRNA nucleotidyltransferase activity ; GO:0009022', also known as 'ribonuclease PH', does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: EC:3.1.-.- is_a: GO:0016788 ! hydrolase activity, acting on ester bonds relationship: part_of GO:0090305 ! nucleic acid phosphodiester bond hydrolysis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004519 name: endonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] subset: gosubset_prok xref: Reactome:REACT_100654 "3'- incision of DNA by XPG in GG-NER, Arabidopsis thaliana" xref: Reactome:REACT_101397 "3'- incision of DNA by XPG in GG-NER, Danio rerio" xref: Reactome:REACT_103600 "3'- incision of DNA by XPG in GG-NER, Gallus gallus" xref: Reactome:REACT_106502 "3'- incision of DNA by XPG in GG-NER, Rattus norvegicus" xref: Reactome:REACT_108614 "3'- incision of DNA by XPG in GG-NER, Taeniopygia guttata" xref: Reactome:REACT_110731 "3'- incision of DNA by XPG in GG-NER, Xenopus tropicalis" xref: Reactome:REACT_112366 "Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Danio rerio" xref: Reactome:REACT_1124 "3'- incision of DNA by XPG in GG-NER, Homo sapiens" xref: Reactome:REACT_112509 "Cleavage of mRNA at the 3'-end, Arabidopsis thaliana" xref: Reactome:REACT_112615 "Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Rattus norvegicus" xref: Reactome:REACT_112782 "Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Xenopus tropicalis" xref: Reactome:REACT_113127 "Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Taeniopygia guttata" xref: Reactome:REACT_113480 "Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Gallus gallus" xref: Reactome:REACT_113819 "Cleavage of mRNA at the 3'-end, Drosophila melanogaster" xref: Reactome:REACT_114931 "Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Canis familiaris" xref: Reactome:REACT_115221 "Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Mus musculus" xref: Reactome:REACT_115226 "Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Bos taurus" xref: Reactome:REACT_115382 "Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Sus scrofa" xref: Reactome:REACT_115937 "Displacement of DNA glycosylase and endonucleolytic cleavage by DNA-lyase, Gallus gallus" xref: Reactome:REACT_116011 "Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Gallus gallus" xref: Reactome:REACT_1914 "Cleavage of mRNA at the 3'-end, Homo sapiens" xref: Reactome:REACT_34610 "Cleavage of mRNA at the 3'-end, Bos taurus" xref: Reactome:REACT_6746 "Removal of 3'-phosphate moiety from DSB ends, Homo sapiens" xref: Reactome:REACT_6774 "Removal of 3'-phosphoglycolate (PG) moiety from DSB ends, Homo sapiens" xref: Reactome:REACT_77706 "Cleavage of mRNA at the 3'-end, Taeniopygia guttata" xref: Reactome:REACT_78624 "3'- incision of DNA by XPG in GG-NER, Canis familiaris" xref: Reactome:REACT_79198 "Cleavage of mRNA at the 3'-end, Canis familiaris" xref: Reactome:REACT_80387 "3'- incision of DNA by XPG in GG-NER, Caenorhabditis elegans" xref: Reactome:REACT_80628 "3'- incision of DNA by XPG in GG-NER, Saccharomyces cerevisiae" xref: Reactome:REACT_80681 "3'- incision of DNA by XPG in GG-NER, Bos taurus" xref: Reactome:REACT_80797 "Cleavage of mRNA at the 3'-end, Mus musculus" xref: Reactome:REACT_81714 "3'- incision of DNA by XPG in GG-NER, Oryza sativa" xref: Reactome:REACT_87541 "Cleavage of mRNA at the 3'-end, Xenopus tropicalis" xref: Reactome:REACT_89800 "3'- incision of DNA by XPG in GG-NER, Schizosaccharomyces pombe" xref: Reactome:REACT_90034 "3'- incision of DNA by XPG in GG-NER, Mus musculus" xref: Reactome:REACT_90935 "3'- incision of DNA by XPG in GG-NER, Sus scrofa" xref: Reactome:REACT_92894 "3'- incision of DNA by XPG in GG-NER, Drosophila melanogaster" is_a: GO:0004518 ! nuclease activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004520 name: endodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684] subset: gosubset_prok synonym: "DNA nicking activity" RELATED [GOC:mah] synonym: "endonuclease G activity" RELATED [] xref: Reactome:REACT_101184 "5'-incision of DNA by ERCC1-XPF in GG-NER, Danio rerio" xref: Reactome:REACT_101250 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Caenorhabditis elegans" xref: Reactome:REACT_101987 "APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Dictyostelium discoideum" xref: Reactome:REACT_103441 "APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Rattus norvegicus" xref: Reactome:REACT_103771 "3' incision of the lesioned strand of DNA in TC-NER, Xenopus tropicalis" xref: Reactome:REACT_104010 "APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Danio rerio" xref: Reactome:REACT_104673 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Schizosaccharomyces pombe" xref: Reactome:REACT_104703 "APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Taeniopygia guttata" xref: Reactome:REACT_104968 "APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Sus scrofa" xref: Reactome:REACT_106756 "3' incision of the lesioned strand of DNA in TC-NER, Drosophila melanogaster" xref: Reactome:REACT_109040 "3' incision of the lesioned strand of DNA in TC-NER, Canis familiaris" xref: Reactome:REACT_109537 "APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Xenopus tropicalis" xref: Reactome:REACT_109692 "3' incision of the lesioned strand of DNA in TC-NER, Sus scrofa" xref: Reactome:REACT_110386 "3' incision of the lesioned strand of DNA in TC-NER, Danio rerio" xref: Reactome:REACT_112122 "5'-incision of DNA by ERCC1-XPF in GG-NER, Xenopus tropicalis" xref: Reactome:REACT_112152 "3' incision of the lesioned strand of DNA in TC-NER, Taeniopygia guttata" xref: Reactome:REACT_115154 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Gallus gallus" xref: Reactome:REACT_115463 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Taeniopygia guttata" xref: Reactome:REACT_115479 "3' incision of the lesioned strand of DNA in TC-NER, Gallus gallus" xref: Reactome:REACT_1274 "3' incision of the lesioned strand of DNA in TC-NER, Homo sapiens" xref: Reactome:REACT_1311 "5'-incision of DNA by ERCC1-XPF in GG-NER, Homo sapiens" xref: Reactome:REACT_1964 "APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Homo sapiens" xref: Reactome:REACT_27164 "Removal of SPO11 and Resection of 5' Ends of DNA (yeast), Saccharomyces cerevisiae" xref: Reactome:REACT_27209 "Removal of SPO11 and Resection of 5' Ends of DNA, Homo sapiens" xref: Reactome:REACT_28610 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Bos taurus" xref: Reactome:REACT_28960 "3' incision of the lesioned strand of DNA in TC-NER, Rattus norvegicus" xref: Reactome:REACT_30718 "3' incision of the lesioned strand of DNA in TC-NER, Dictyostelium discoideum" xref: Reactome:REACT_31162 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Arabidopsis thaliana" xref: Reactome:REACT_31548 "APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Caenorhabditis elegans" xref: Reactome:REACT_31660 "3' incision of the lesioned strand of DNA in TC-NER, Schizosaccharomyces pombe" xref: Reactome:REACT_31823 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Oryza sativa" xref: Reactome:REACT_32833 "3' incision of the lesioned strand of DNA in TC-NER, Saccharomyces cerevisiae" xref: Reactome:REACT_33043 "3' incision of the lesioned strand of DNA in TC-NER, Bos taurus" xref: Reactome:REACT_78421 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Sus scrofa" xref: Reactome:REACT_79265 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Dictyostelium discoideum" xref: Reactome:REACT_80173 "APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Mus musculus" xref: Reactome:REACT_80298 "3' incision of the lesioned strand of DNA in TC-NER, Caenorhabditis elegans" xref: Reactome:REACT_80967 "3' incision of the lesioned strand of DNA in TC-NER, Oryza sativa" xref: Reactome:REACT_811 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Homo sapiens" xref: Reactome:REACT_81197 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Mus musculus" xref: Reactome:REACT_82925 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Canis familiaris" xref: Reactome:REACT_83838 "5'-incision of DNA by ERCC1-XPF in GG-NER, Rattus norvegicus" xref: Reactome:REACT_85019 "APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Drosophila melanogaster" xref: Reactome:REACT_88339 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Rattus norvegicus" xref: Reactome:REACT_90087 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Danio rerio" xref: Reactome:REACT_92741 "3' incision of the lesioned strand of DNA in TC-NER, Arabidopsis thaliana" xref: Reactome:REACT_94592 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Drosophila melanogaster" xref: Reactome:REACT_94820 "APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Canis familiaris" xref: Reactome:REACT_95903 "5'-incision of DNA by ERCC1-XPF in GG-NER, Mus musculus" xref: Reactome:REACT_97114 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Xenopus tropicalis" xref: Reactome:REACT_98405 "5' incision leading to excision of DNA fragment with lesion in TC-NER, Saccharomyces cerevisiae" xref: Reactome:REACT_98417 "APE1 mediated endonucleolytic cleavage at the 5' side of the base-free deoxyribose residue, Bos taurus" xref: Reactome:REACT_99783 "3' incision of the lesioned strand of DNA in TC-NER, Mus musculus" is_a: GO:0004519 ! endonuclease activity is_a: GO:0004536 ! deoxyribonuclease activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004527 name: exonuclease activity namespace: molecular_function alt_id: GO:0008857 def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] subset: gosubset_prok synonym: "exonuclease IX activity" NARROW [] is_a: GO:0004518 ! nuclease activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004528 name: phosphodiesterase I activity namespace: molecular_function def: "Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides." [EC:3.1.4.1] subset: gosubset_prok synonym: "5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" EXACT [EC:3.1.4.1] synonym: "5'-exonuclease activity" RELATED [EC:3.1.4.1] synonym: "5'-NPDase activity" RELATED [EC:3.1.4.1] synonym: "5'-nucleotide phosphodiesterase activity" RELATED [EC:3.1.4.1] synonym: "5'-PDase activity" RELATED [EC:3.1.4.1] synonym: "5'-PDE activity" RELATED [EC:3.1.4.1] synonym: "5'-phosphodiesterase activity" RELATED [EC:3.1.4.1] synonym: "5'NPDE activity" RELATED [EC:3.1.4.1] synonym: "alkaline phosphodiesterase activity" RELATED [EC:3.1.4.1] synonym: "exonuclease I activity" RELATED [EC:3.1.4.1] synonym: "nucleotide pyrophosphatase/phosphodiesterase I activity" EXACT [EC:3.1.4.1] synonym: "oligonucleate 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.1] synonym: "orthophosphoric diester phosphohydrolase activity" EXACT [EC:3.1.4.1] synonym: "PDE I activity" EXACT [EC:3.1.4.1] synonym: "phosphodiesterase activity" BROAD [EC:3.1.4.1] xref: EC:3.1.4.1 xref: MetaCyc:3.1.4.1-RXN is_a: GO:0004527 ! exonuclease activity is_a: GO:0008081 ! phosphoric diester hydrolase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004529 name: exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule." [GOC:mah, ISBN:0198547684] subset: gosubset_prok is_a: GO:0004527 ! exonuclease activity is_a: GO:0004536 ! deoxyribonuclease activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004532 name: exoribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684] subset: gosubset_prok xref: Reactome:REACT_109605 "Scavenging of the 7-methylguanosine Cap by DCPS, Sus scrofa" xref: Reactome:REACT_109680 "Scavenging of the 7-methylguanosine Cap by DCPS, Rattus norvegicus" xref: Reactome:REACT_20556 "Scavenging of the 7-methylguanosine Cap by DCPS, Homo sapiens" xref: Reactome:REACT_29104 "Scavenging of the 7-methylguanosine Cap by DCPS, Danio rerio" xref: Reactome:REACT_32104 "Scavenging of the 7-methylguanosine Cap by DCPS, Bos taurus" xref: Reactome:REACT_78260 "Scavenging of the 7-methylguanosine Cap by DCPS, Xenopus tropicalis" xref: Reactome:REACT_79364 "Scavenging of the 7-methylguanosine Cap by DCPS, Gallus gallus" xref: Reactome:REACT_79874 "Scavenging of the 7-methylguanosine Cap by DCPS, Taeniopygia guttata" xref: Reactome:REACT_87278 "Scavenging of the 7-methylguanosine Cap by DCPS, Drosophila melanogaster" xref: Reactome:REACT_88925 "Scavenging of the 7-methylguanosine Cap by DCPS, Caenorhabditis elegans" xref: Reactome:REACT_90233 "Scavenging of the 7-methylguanosine Cap by DCPS, Canis familiaris" xref: Reactome:REACT_94168 "Scavenging of the 7-methylguanosine Cap by DCPS, Schizosaccharomyces pombe" xref: Reactome:REACT_99687 "Scavenging of the 7-methylguanosine Cap by DCPS, Mus musculus" xref: Reactome:REACT_99790 "Scavenging of the 7-methylguanosine Cap by DCPS, Saccharomyces cerevisiae" is_a: GO:0004527 ! exonuclease activity is_a: GO:0004540 ! ribonuclease activity relationship: part_of GO:0090503 ! RNA phosphodiester bond hydrolysis, exonucleolytic property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004536 name: deoxyribonuclease activity namespace: molecular_function alt_id: GO:0004537 def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah, ISBN:0198547684] subset: gosubset_prok synonym: "caspase-activated deoxyribonuclease activity" NARROW [] xref: Reactome:REACT_100642 "Cleavage of DNA by DFF40, Xenopus tropicalis" xref: Reactome:REACT_101208 "Cleavage of DNA by DFF40, Bos taurus" xref: Reactome:REACT_110575 "Cleavage of DNA by DFF40, Sus scrofa" xref: Reactome:REACT_13702 "Cleavage of DNA by DFF40, Homo sapiens" xref: Reactome:REACT_29722 "Cleavage of DNA by DFF40, Danio rerio" xref: Reactome:REACT_31853 "Cleavage of DNA by DFF40, Taeniopygia guttata" xref: Reactome:REACT_90424 "Cleavage of DNA by DFF40, Gallus gallus" xref: Reactome:REACT_95359 "Cleavage of DNA by DFF40, Rattus norvegicus" xref: Reactome:REACT_98682 "Cleavage of DNA by DFF40, Canis familiaris" is_a: GO:0004518 ! nuclease activity relationship: part_of GO:0006259 ! DNA metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004540 name: ribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684] subset: gosubset_prok is_a: GO:0004518 ! nuclease activity relationship: part_of GO:0090501 ! RNA phosphodiester bond hydrolysis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004550 name: nucleoside diphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6] subset: gosubset_prok synonym: "ATP:nucleoside-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.6] synonym: "NDK activity" EXACT [EC:2.7.4.6] synonym: "nucleoside 5'-diphosphate kinase activity" EXACT [EC:2.7.4.6] synonym: "nucleoside 5'-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.6] synonym: "nucleoside diphosphate (UDP) kinase activity" EXACT [EC:2.7.4.6] synonym: "nucleoside diphosphokinase activity" EXACT [EC:2.7.4.6] synonym: "nucleoside-diphosphate kinase activity" EXACT [] synonym: "nucleotide phosphate kinase activity" EXACT [EC:2.7.4.6] synonym: "UDP kinase activity" EXACT [EC:2.7.4.6] synonym: "uridine diphosphate kinase activity" EXACT [EC:2.7.4.6] xref: EC:2.7.4.6 xref: MetaCyc:NUCLEOSIDE-DIP-KIN-RXN xref: Reactome:REACT_21273 "(d)NTP + ADP <=> (d)NDP + ATP [NME1,2,3], Homo sapiens" xref: Reactome:REACT_21292 "(d)NTP + ADP <=> (d)NDP + ATP [NME4], Homo sapiens" xref: Reactome:REACT_21362 "(d)NDP + ATP <=> (d)NTP + ADP [NME4], Homo sapiens" xref: Reactome:REACT_21416 "(d)NDP + ATP <=> (d)NTP + ADP [NME1,2,3], Homo sapiens" is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor is_a: GO:0019205 ! nucleobase-containing compound kinase activity relationship: part_of GO:0006165 ! nucleoside diphosphate phosphorylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004551 name: nucleotide diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides." [EC:3.6.1.9] subset: gosubset_prok synonym: "dinucleotide nucleotidohydrolase activity" EXACT [EC:3.6.1.9] synonym: "nucleotide pyrophosphatase activity" EXACT [] synonym: "nucleotide-sugar pyrophosphatase activity" EXACT [EC:3.6.1.9] xref: EC:3.6.1.9 xref: MetaCyc:NUCLEOTIDE-PYROPHOSPHATASE-RXN xref: Reactome:REACT_100849 "FAD can be hydrolyzed back to FMN, Saccharomyces cerevisiae" xref: Reactome:REACT_101743 "FAD can be hydrolyzed back to FMN, Dictyostelium discoideum" xref: Reactome:REACT_105775 "FAD can be hydrolyzed back to FMN, Schizosaccharomyces pombe" xref: Reactome:REACT_11150 "FAD can be hydrolyzed back to FMN, Homo sapiens" xref: Reactome:REACT_114734 "FAD can be hydrolyzed back to FMN, Xenopus tropicalis" xref: Reactome:REACT_31241 "FAD can be hydrolyzed back to FMN, Bos taurus" xref: Reactome:REACT_32231 "FAD can be hydrolyzed back to FMN, Danio rerio" xref: Reactome:REACT_32788 "FAD can be hydrolyzed back to FMN, Mus musculus" xref: Reactome:REACT_79725 "FAD can be hydrolyzed back to FMN, Taeniopygia guttata" xref: Reactome:REACT_81072 "FAD can be hydrolyzed back to FMN, Oryza sativa" xref: Reactome:REACT_85470 "FAD can be hydrolyzed back to FMN, Sus scrofa" xref: Reactome:REACT_88676 "FAD can be hydrolyzed back to FMN, Rattus norvegicus" xref: Reactome:REACT_90125 "FAD can be hydrolyzed back to FMN, Canis familiaris" xref: Reactome:REACT_90152 "FAD can be hydrolyzed back to FMN, Arabidopsis thaliana" xref: Reactome:REACT_93217 "FAD can be hydrolyzed back to FMN, Gallus gallus" is_a: GO:0016462 ! pyrophosphatase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004553 name: hydrolase activity, hydrolyzing O-glycosyl compounds namespace: molecular_function alt_id: GO:0016800 def: "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] subset: gosubset_prok synonym: "O-glucosyl hydrolase activity" EXACT [] xref: EC:3.2.1 is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004555 name: alpha,alpha-trehalase activity namespace: molecular_function def: "Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose." [EC:3.2.1.28] subset: gosubset_prok synonym: "alpha,alpha-trehalose glucohydrolase activity" EXACT [EC:3.2.1.28] xref: EC:3.2.1.28 xref: MetaCyc:TREHALA-RXN xref: Reactome:REACT_100752 "trehalose + H2O => 2 D-glucose, Dictyostelium discoideum" xref: Reactome:REACT_107937 "trehalose + H2O => 2 D-glucose, Caenorhabditis elegans" xref: Reactome:REACT_108455 "trehalose + H2O => 2 D-glucose, Mus musculus" xref: Reactome:REACT_113083 "trehalose + H2O => 2 D-glucose, Escherichia coli" xref: Reactome:REACT_28802 "trehalose + H2O => 2 D-glucose, Rattus norvegicus" xref: Reactome:REACT_33073 "trehalose + H2O => 2 D-glucose, Bos taurus" xref: Reactome:REACT_62235 "trehalose + H2O => 2 D-glucose, Canis familiaris" xref: Reactome:REACT_83023 "trehalose + H2O => 2 D-glucose, Oryza sativa" xref: Reactome:REACT_85697 "trehalose + H2O => 2 D-glucose, Xenopus tropicalis" xref: Reactome:REACT_86912 "trehalose + H2O => 2 D-glucose, Schizosaccharomyces pombe" xref: Reactome:REACT_88617 "trehalose + H2O => 2 D-glucose, Danio rerio" xref: Reactome:REACT_91694 "trehalose + H2O => 2 D-glucose, Arabidopsis thaliana" xref: Reactome:REACT_9425 "trehalose + H2O => 2 D-glucose, Homo sapiens" xref: Reactome:REACT_9495 "trehalose + H2O => 2 D-glucose, Oryctolagus cuniculus" xref: Reactome:REACT_96425 "trehalose + H2O => 2 D-glucose, Drosophila melanogaster" xref: RHEA:20871 is_a: GO:0015927 ! trehalase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004557 name: alpha-galactosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactohydrolase." [EC:3.2.1.22] subset: gosubset_prok synonym: "alpha-D-galactosidase activity" EXACT [EC:3.2.1.22] synonym: "alpha-D-galactoside galactohydrolase activity" EXACT [EC:3.2.1.22] synonym: "alpha-galactosidase A" RELATED [EC:3.2.1.22] synonym: "alpha-galactoside galactohydrolase activity" EXACT [EC:3.2.1.22] synonym: "melibiase activity" EXACT [] xref: EC:3.2.1.22 xref: MetaCyc:ALPHAGALACTOSID-RXN xref: Reactome:REACT_115752 "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers, Homo sapiens" is_a: GO:0015925 ! galactosidase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004558 name: alpha-1,4-glucosidase activity namespace: molecular_function alt_id: GO:0004562 alt_id: GO:0016982 def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose." [EC:3.2.1.20] subset: gosubset_prok synonym: "acid maltase activity" EXACT [EC:3.2.1.20] synonym: "alpha-1,4-glucosidase activity" EXACT [EC:3.2.1.20] synonym: "alpha-D-glucosidase activity" EXACT [EC:3.2.1.20] synonym: "alpha-D-glucoside glucohydrolase activity" EXACT [EC:3.2.1.20] synonym: "alpha-glucopyranosidase activity" EXACT [EC:3.2.1.20] synonym: "alpha-glucosidase II" RELATED [] synonym: "alpha-glucoside hydrolase activity" EXACT [EC:3.2.1.20] synonym: "glucoinvertase activity" EXACT [EC:3.2.1.20] synonym: "glucosidoinvertase activity" EXACT [EC:3.2.1.20] synonym: "glucosidosucrase activity" EXACT [EC:3.2.1.20] synonym: "lysosomal alpha-glucosidase activity" BROAD [EC:3.2.1.20] synonym: "maltase-glucoamylase activity" EXACT [EC:3.2.1.20] xref: EC:3.2.1.20 xref: MetaCyc:MALTODEXGLUCOSID-RXN xref: Reactome:REACT_100920 "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose, Rattus norvegicus" xref: Reactome:REACT_102012 "maltose + H2O => 2 D-glucose (sucrase-isomaltase), Canis familiaris" xref: Reactome:REACT_103965 "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase), Sus scrofa" xref: Reactome:REACT_103976 "maltose + H2O => 2 D-glucose (sucrase-isomaltase), Danio rerio" xref: Reactome:REACT_108880 "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase), Rattus norvegicus" xref: Reactome:REACT_112486 "maltose + H2O => 2 D-glucose (sucrase-isomaltase), Taeniopygia guttata" xref: Reactome:REACT_113312 "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose, Taeniopygia guttata" xref: Reactome:REACT_114036 "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase), Taeniopygia guttata" xref: Reactome:REACT_32591 "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase), Bos taurus" xref: Reactome:REACT_53202 "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose, Sus scrofa" xref: Reactome:REACT_80032 "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose, Canis familiaris" xref: Reactome:REACT_82469 "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose, Mus musculus" xref: Reactome:REACT_82683 "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase), Mus musculus" xref: Reactome:REACT_84778 "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose, Bos taurus" xref: Reactome:REACT_84962 "maltose + H2O => 2 D-glucose (sucrase-isomaltase), Xenopus tropicalis" xref: Reactome:REACT_88169 "maltose + H2O => 2 D-glucose (sucrase-isomaltase), Rattus norvegicus" xref: Reactome:REACT_88678 "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase), Xenopus tropicalis" xref: Reactome:REACT_88835 "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose, Xenopus tropicalis" xref: Reactome:REACT_89837 "maltose + H2O => 2 D-glucose (sucrase-isomaltase), Bos taurus" xref: Reactome:REACT_94010 "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase), Danio rerio" xref: Reactome:REACT_9414 "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose, Homo sapiens" xref: Reactome:REACT_9424 "maltose + H2O => 2 D-glucose (maltase-glucoamylase), Homo sapiens" xref: Reactome:REACT_9426 "maltose + H2O => 2 D-glucose (sucrase-isomaltase), Homo sapiens" xref: Reactome:REACT_9479 "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase), Homo sapiens" xref: Reactome:REACT_9506 "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase), Homo sapiens" xref: Reactome:REACT_95331 "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase), Canis familiaris" xref: Reactome:REACT_97286 "maltose + H2O => 2 D-glucose (sucrase-isomaltase), Mus musculus" xref: Reactome:REACT_97290 "maltose + H2O => 2 D-glucose (sucrase-isomaltase), Sus scrofa" xref: Reactome:REACT_97456 "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose, Danio rerio" is_a: GO:0090599 ! alpha-glucosidase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004585 name: ornithine carbamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline." [EC:2.1.3.3] subset: gosubset_prok synonym: "carbamoyl-phosphate:L-ornithine carbamoyltransferase activity" EXACT [EC:2.1.3.3] synonym: "carbamylphosphate-ornithine transcarbamylase activity" EXACT [EC:2.1.3.3] synonym: "citrulline phosphorylase activity" EXACT [EC:2.1.3.3] synonym: "L-ornithine carbamoyltransferase activity" EXACT [EC:2.1.3.3] synonym: "L-ornithine carbamyltransferase activity" EXACT [EC:2.1.3.3] synonym: "L-ornithine transcarbamylase activity" EXACT [EC:2.1.3.3] synonym: "ornithine carbamyltransferase activity" EXACT [EC:2.1.3.3] synonym: "ornithine transcarbamylase activity" EXACT [EC:2.1.3.3] synonym: "OTC activity" EXACT [EC:2.1.3.3] synonym: "OTCase activity" EXACT [EC:2.1.3.3] xref: EC:2.1.3.3 xref: MetaCyc:ORNCARBAMTRANSFER-RXN xref: Reactome:REACT_102870 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Arabidopsis thaliana" xref: Reactome:REACT_105226 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Saccharomyces cerevisiae" xref: Reactome:REACT_106259 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Canis familiaris" xref: Reactome:REACT_108269 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Mus musculus" xref: Reactome:REACT_108782 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Danio rerio" xref: Reactome:REACT_115561 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Gallus gallus" xref: Reactome:REACT_29449 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Gallus gallus" xref: Reactome:REACT_30313 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Rattus norvegicus" xref: Reactome:REACT_30784 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Mycobacterium tuberculosis" xref: Reactome:REACT_32381 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Xenopus tropicalis" xref: Reactome:REACT_32826 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Escherichia coli" xref: Reactome:REACT_75706 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Schizosaccharomyces pombe" xref: Reactome:REACT_77338 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Bos taurus" xref: Reactome:REACT_78698 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Staphylococcus aureus N315" xref: Reactome:REACT_801 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Homo sapiens" xref: Reactome:REACT_83411 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Plasmodium falciparum" xref: Reactome:REACT_91782 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Sus scrofa" xref: Reactome:REACT_95450 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Taeniopygia guttata" xref: Reactome:REACT_96735 "carbamoyl phosphate + ornithine => citrulline + orthophosphate, Oryza sativa" xref: RHEA:19516 is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity relationship: part_of GO:0006591 ! ornithine metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004596 name: peptide alpha-N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein." [EC:2.3.1.88, GOC:mah] subset: gosubset_prok synonym: "acetyl-CoA:peptide alpha-N-acetyltransferase activity" EXACT [EC:2.3.1.88] synonym: "acetyl-CoA:peptide nalpha-acetyltransferase activity" EXACT [EC:2.3.1.88] synonym: "amino-terminal amino acid-acetylating enzyme activity" RELATED [EC:2.3.1.88] synonym: "beta-endorphin acetyltransferase activity" NARROW [EC:2.3.1.88] synonym: "N(alpha)-acetyltransferase activity" RELATED [EC:2.3.1.88] synonym: "nalpha-acetyltransferase activity" EXACT [EC:2.3.1.88] synonym: "NAT activity" RELATED [EC:2.3.1.88] synonym: "peptide acetyltransferase activity" RELATED [EC:2.3.1.88] synonym: "protein N-terminal acetyltransferase activity" EXACT [EC:2.3.1.88] xref: EC:2.3.1.88 xref: MetaCyc:PEPTIDE-ALPHA-N-ACETYLTRANSFERASE-RXN is_a: GO:0034212 ! peptide N-acetyltransferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004601 name: peroxidase activity namespace: molecular_function alt_id: GO:0016685 alt_id: GO:0016686 alt_id: GO:0016687 alt_id: GO:0016693 def: "Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7] subset: gosubset_prok synonym: "bacterial catalase-peroxidase activity" NARROW [] synonym: "donor:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.7] synonym: "eosinophil peroxidase activity" NARROW [] synonym: "extensin peroxidase" NARROW [EC:1.11.1.7] synonym: "guaiacol peroxidase" NARROW [EC:1.11.1.7] synonym: "heme peroxidase" NARROW [EC:1.11.1.7] synonym: "horseradish peroxidase (HRP)" NARROW [EC:1.11.1.7] synonym: "japanese radish peroxidase" NARROW [EC:1.11.1.7] synonym: "lactoperoxidase activity" NARROW [] synonym: "MPO" RELATED [EC:1.11.1.7] synonym: "myeloperoxidase activity" NARROW [] synonym: "oxyperoxidase activity" EXACT [EC:1.11.1.7] synonym: "peroxidase reaction" EXACT [] synonym: "protoheme peroxidase" NARROW [EC:1.11.1.7] synonym: "pyrocatechol peroxidase" NARROW [EC:1.11.1.7] synonym: "scopoletin peroxidase" NARROW [EC:1.11.1.7] synonym: "secretory plant peroxidase activity" NARROW [] synonym: "thiocyanate peroxidase" NARROW [EC:1.11.1.7] synonym: "verdoperoxidase" NARROW [EC:1.11.1.7] xref: EC:1.11.1.7 xref: KEGG:R03532 xref: MetaCyc:PEROXID-RXN xref: Reactome:REACT_100373 "Peroxidative reduction of PGG2 to PGH2, Bos taurus" xref: Reactome:REACT_101046 "DIT and MIT combine to form triiodothyronine, Sus scrofa" xref: Reactome:REACT_101589 "Tyrosine is diiodinated, Rattus norvegicus" xref: Reactome:REACT_102144 "Peroxidative reduction of PGG2 to PGH2, Taeniopygia guttata" xref: Reactome:REACT_104442 "Tyrosine is diiodinated, Canis familiaris" xref: Reactome:REACT_105725 "Peroxidative reduction of PGG2 to PGH2, Mus musculus" xref: Reactome:REACT_106670 "Tyrosine is diiodinated, Mus musculus" xref: Reactome:REACT_108020 "Iodide is organified, Rattus norvegicus" xref: Reactome:REACT_108229 "Peroxidative reduction of PGG2 to PGH2, Gallus gallus" xref: Reactome:REACT_111983 "Tyrosine is monoiodinated, Dictyostelium discoideum" xref: Reactome:REACT_112213 "Iodide is organified, Danio rerio" xref: Reactome:REACT_112249 "Tyrosine is diiodinated, Dictyostelium discoideum" xref: Reactome:REACT_113235 "Tyrosine is diiodinated, Danio rerio" xref: Reactome:REACT_113904 "DIT and MIT combine to form triiodothyronine, Dictyostelium discoideum" xref: Reactome:REACT_113988 "Two DITs combine to form thyroxine, Dictyostelium discoideum" xref: Reactome:REACT_114100 "Iodide is organified, Dictyostelium discoideum" xref: Reactome:REACT_114351 "Tyrosine is monoiodinated, Danio rerio" xref: Reactome:REACT_114796 "DIT and MIT combine to form triiodothyronine, Danio rerio" xref: Reactome:REACT_115058 "Two DITs combine to form thyroxine, Danio rerio" xref: Reactome:REACT_15360 "DIT and MIT combine to form triiodothyronine, Homo sapiens" xref: Reactome:REACT_15430 "Two DITs combine to form thyroxine, Homo sapiens" xref: Reactome:REACT_15445 "Tyrosine is monoiodinated, Homo sapiens" xref: Reactome:REACT_15455 "Tyrosine is diiodinated, Homo sapiens" xref: Reactome:REACT_15539 "Iodide is organified, Homo sapiens" xref: Reactome:REACT_28086 "Tyrosine is monoiodinated, Canis familiaris" xref: Reactome:REACT_28372 "Two DITs combine to form thyroxine, Taeniopygia guttata" xref: Reactome:REACT_29881 "Peroxidative reduction of PGG2 to PGH2, Canis familiaris" xref: Reactome:REACT_30736 "Two DITs combine to form thyroxine, Rattus norvegicus" xref: Reactome:REACT_30826 "DIT and MIT combine to form triiodothyronine, Rattus norvegicus" xref: Reactome:REACT_31807 "Peroxidative reduction of PGG2 to PGH2, Sus scrofa" xref: Reactome:REACT_32140 "Peroxidative reduction of PGG2 to PGH2, Xenopus tropicalis" xref: Reactome:REACT_32854 "Peroxidative reduction of PGG2 to PGH2, Danio rerio" xref: Reactome:REACT_33827 "Two DITs combine to form thyroxine, Sus scrofa" xref: Reactome:REACT_33837 "Tyrosine is monoiodinated, Taeniopygia guttata" xref: Reactome:REACT_76985 "Iodide is organified, Mus musculus" xref: Reactome:REACT_78273 "DIT and MIT combine to form triiodothyronine, Xenopus tropicalis" xref: Reactome:REACT_78937 "Iodide is organified, Gallus gallus" xref: Reactome:REACT_79084 "Tyrosine is diiodinated, Xenopus tropicalis" xref: Reactome:REACT_79114 "DIT and MIT combine to form triiodothyronine, Canis familiaris" xref: Reactome:REACT_810 "Peroxidative reduction of PGG2 to PGH2, Homo sapiens" xref: Reactome:REACT_81922 "Two DITs combine to form thyroxine, Canis familiaris" xref: Reactome:REACT_82000 "Tyrosine is monoiodinated, Rattus norvegicus" xref: Reactome:REACT_85332 "Two DITs combine to form thyroxine, Mus musculus" xref: Reactome:REACT_85339 "Iodide is organified, Xenopus tropicalis" xref: Reactome:REACT_85899 "Tyrosine is diiodinated, Taeniopygia guttata" xref: Reactome:REACT_86613 "Tyrosine is monoiodinated, Mus musculus" xref: Reactome:REACT_87489 "Iodide is organified, Canis familiaris" xref: Reactome:REACT_87731 "Tyrosine is diiodinated, Gallus gallus" xref: Reactome:REACT_88313 "Iodide is organified, Taeniopygia guttata" xref: Reactome:REACT_90277 "Two DITs combine to form thyroxine, Gallus gallus" xref: Reactome:REACT_90987 "Tyrosine is diiodinated, Sus scrofa" xref: Reactome:REACT_91636 "Tyrosine is monoiodinated, Gallus gallus" xref: Reactome:REACT_91853 "Tyrosine is monoiodinated, Xenopus tropicalis" xref: Reactome:REACT_92128 "DIT and MIT combine to form triiodothyronine, Mus musculus" xref: Reactome:REACT_94963 "Tyrosine is monoiodinated, Sus scrofa" xref: Reactome:REACT_96008 "DIT and MIT combine to form triiodothyronine, Taeniopygia guttata" xref: Reactome:REACT_97146 "Iodide is organified, Sus scrofa" xref: Reactome:REACT_97248 "Two DITs combine to form thyroxine, Xenopus tropicalis" xref: Reactome:REACT_97539 "Peroxidative reduction of PGG2 to PGH2, Rattus norvegicus" xref: Reactome:REACT_98848 "DIT and MIT combine to form triiodothyronine, Gallus gallus" xref: RHEA:23637 is_a: GO:0016209 ! antioxidant activity is_a: GO:0016684 ! oxidoreductase activity, acting on peroxide as acceptor property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004602 name: glutathione peroxidase activity namespace: molecular_function alt_id: GO:0016224 def: "Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9] subset: gosubset_prok synonym: "glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.9] synonym: "GSH peroxidase activity" EXACT [EC:1.11.1.9] synonym: "non-selenium glutathione peroxidase activity" NARROW [] synonym: "reduced glutathione peroxidase activity" EXACT [EC:1.11.1.9] synonym: "selenium-glutathione peroxidase activity" EXACT [EC:1.11.1.9] xref: EC:1.11.1.9 xref: MetaCyc:GLUTATHIONE-PEROXIDASE-RXN xref: Reactome:REACT_106570 "2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O, Mus musculus" xref: Reactome:REACT_112920 "2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O, Danio rerio" xref: Reactome:REACT_113573 "2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O, Plasmodium falciparum" xref: Reactome:REACT_114008 "2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O, Escherichia coli" xref: Reactome:REACT_2037 "2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O, Homo sapiens" xref: Reactome:REACT_81396 "2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O, Taeniopygia guttata" xref: Reactome:REACT_96265 "2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O, Canis familiaris" xref: RHEA:16836 is_a: GO:0004601 ! peroxidase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004619 name: phosphoglycerate mutase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate." [EC:5.4.2.1] subset: gosubset_prok synonym: "bisphosphoglyceromutase" RELATED [EC:5.4.2.1] synonym: "D-phosphoglycerate 2,3-phosphomutase activity" EXACT [EC:5.4.2.1] synonym: "diphosphoglycomutase" RELATED [EC:5.4.2.1] synonym: "GriP mutase" NARROW [EC:5.4.2.1] synonym: "monophosphoglycerate mutase activity" EXACT [EC:5.4.2.1] synonym: "monophosphoglyceromutase activity" EXACT [EC:5.4.2.1] synonym: "MPGM" RELATED [EC:5.4.2.1] synonym: "PGA mutase activity" EXACT [EC:5.4.2.1] synonym: "PGAM activity" EXACT [EC:5.4.2.1] synonym: "PGM" EXACT [] synonym: "phosphoglycerate phosphomutase activity" EXACT [EC:5.4.2.1] synonym: "phosphoglyceromutase activity" EXACT [EC:5.4.2.1] xref: EC:5.4.2.1 xref: MetaCyc:3PGAREARR-RXN xref: Reactome:REACT_103744 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Oryza sativa" xref: Reactome:REACT_104989 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Staphylococcus aureus N315" xref: Reactome:REACT_105247 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Danio rerio" xref: Reactome:REACT_106697 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Sus scrofa" xref: Reactome:REACT_111991 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Plasmodium falciparum" xref: Reactome:REACT_112712 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Plasmodium falciparum" xref: Reactome:REACT_112969 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Escherichia coli" xref: Reactome:REACT_114968 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Dictyostelium discoideum" xref: Reactome:REACT_115206 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Dictyostelium discoideum" xref: Reactome:REACT_115355 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Escherichia coli" xref: Reactome:REACT_116032 "3-phosphoglycerate <=> 2-phosphoglycerate, Gallus gallus" xref: Reactome:REACT_116142 "2-phosphoglycerate <=> 3-phosphoglycerate, Gallus gallus" xref: Reactome:REACT_29464 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Bos taurus" xref: Reactome:REACT_29474 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Drosophila melanogaster" xref: Reactome:REACT_31484 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Rattus norvegicus" xref: Reactome:REACT_576 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Homo sapiens" xref: Reactome:REACT_766 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Homo sapiens" xref: Reactome:REACT_80395 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Bos taurus" xref: Reactome:REACT_81431 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Arabidopsis thaliana" xref: Reactome:REACT_81432 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Rattus norvegicus" xref: Reactome:REACT_82081 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Mus musculus" xref: Reactome:REACT_82507 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Canis familiaris" xref: Reactome:REACT_88463 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Oryza sativa" xref: Reactome:REACT_89277 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Staphylococcus aureus N315" xref: Reactome:REACT_91956 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Drosophila melanogaster" xref: Reactome:REACT_92327 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Xenopus tropicalis" xref: Reactome:REACT_92964 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Sus scrofa" xref: Reactome:REACT_94038 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Danio rerio" xref: Reactome:REACT_94108 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Mus musculus" xref: Reactome:REACT_94205 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Xenopus tropicalis" xref: Reactome:REACT_95665 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Schizosaccharomyces pombe" xref: Reactome:REACT_96558 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Arabidopsis thaliana" xref: Reactome:REACT_96674 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate, Canis familiaris" xref: Reactome:REACT_96785 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate, Schizosaccharomyces pombe" xref: RHEA:15904 is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004637 name: phosphoribosylamine-glycine ligase activity namespace: molecular_function def: "Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate." [EC:6.3.4.13, RHEA:17456] subset: gosubset_prok synonym: "2-amino-N-ribosylacetamide 5'-phosphate kinosynthase activity" EXACT [EC:6.3.4.13] synonym: "5'-phosphoribosylglycinamide synthetase activity" EXACT [EC:6.3.4.13] synonym: "5-phospho-D-ribosylamine:glycine ligase (ADP-forming)" EXACT [EC:6.3.4.13] synonym: "GAR" RELATED [EC:6.3.4.13] synonym: "GAR synthetase activity" EXACT [EC:6.3.4.13] synonym: "GARS activity" EXACT [EC:6.3.4.13] synonym: "glycinamide ribonucleotide synthetase activity" EXACT [EC:6.3.4.13] synonym: "glycineamide ribonucleotide synthetase activity" EXACT [EC:6.3.4.13] synonym: "phosphoribosylglycinamide synthetase activity" EXACT [EC:6.3.4.13] synonym: "phosphoribosylglycineamide synthetase activity" EXACT [EC:6.3.4.13] xref: EC:6.3.4.13 xref: KEGG:R04144 xref: MetaCyc:GLYRIBONUCSYN-RXN xref: Reactome:REACT_103071 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Drosophila melanogaster" xref: Reactome:REACT_104076 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Taeniopygia guttata" xref: Reactome:REACT_106192 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Mus musculus" xref: Reactome:REACT_108489 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Gallus gallus" xref: Reactome:REACT_115925 "5-phosphoribosylamine + glycine + ATP <=> 5-phosphoribosylglycinamide (GAR) + adenosine 5'-diphosphate + orthophosphate, Gallus gallus" xref: Reactome:REACT_285 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Homo sapiens" xref: Reactome:REACT_28848 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Canis familiaris" xref: Reactome:REACT_29216 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Arabidopsis thaliana" xref: Reactome:REACT_77588 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Danio rerio" xref: Reactome:REACT_81216 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Xenopus tropicalis" xref: Reactome:REACT_85338 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Rattus norvegicus" xref: Reactome:REACT_86072 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Saccharomyces cerevisiae" xref: Reactome:REACT_87636 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Escherichia coli" xref: Reactome:REACT_88947 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Staphylococcus aureus N315" xref: Reactome:REACT_90292 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Schizosaccharomyces pombe" xref: Reactome:REACT_93235 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Dictyostelium discoideum" xref: Reactome:REACT_93559 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Caenorhabditis elegans" xref: Reactome:REACT_97521 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Bos taurus" xref: Reactome:REACT_99517 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi, Mycobacterium tuberculosis" xref: RHEA:17456 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004641 name: phosphoribosylformylglycinamidine cyclo-ligase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate." [EC:6.3.3.1, RHEA:23035] subset: gosubset_prok synonym: "2-(formamido)-1-N-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.1] synonym: "2-(formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.1] synonym: "5'-aminoimidazole ribonucleotide synthetase activity" EXACT [EC:6.3.3.1] synonym: "AIR synthase activity" EXACT [EC:6.3.3.1] synonym: "AIR synthetase activity" EXACT [EC:6.3.3.1] synonym: "AIRS activity" EXACT [EC:6.3.3.1] synonym: "phosphoribosyl-aminoimidazole synthetase activity" EXACT [EC:6.3.3.1] synonym: "phosphoribosylaminoimidazole synthetase activity" EXACT [EC:6.3.3.1] xref: EC:6.3.3.1 xref: KEGG:R04208 xref: MetaCyc:AIRS-RXN xref: Reactome:REACT_105364 "FGAM + ATP => AIR + ADP + Pi, Xenopus tropicalis" xref: Reactome:REACT_106728 "FGAM + ATP => AIR + ADP + Pi, Taeniopygia guttata" xref: Reactome:REACT_115615 "5'-phosphoribosylformylglycinamidine (FGAM) + ATP => 5'-phosphoribosyl-5-aminoimidazole (AIR) + ADP + orthophosphate, Gallus gallus" xref: Reactome:REACT_1917 "FGAM + ATP => AIR + ADP + Pi, Homo sapiens" xref: Reactome:REACT_30018 "FGAM + ATP => AIR + ADP + Pi, Arabidopsis thaliana" xref: Reactome:REACT_33275 "FGAM + ATP => AIR + ADP + Pi, Escherichia coli" xref: Reactome:REACT_78085 "FGAM + ATP => AIR + ADP + Pi, Mus musculus" xref: Reactome:REACT_81338 "FGAM + ATP => AIR + ADP + Pi, Saccharomyces cerevisiae" xref: Reactome:REACT_82181 "FGAM + ATP => AIR + ADP + Pi, Drosophila melanogaster" xref: Reactome:REACT_82307 "FGAM + ATP => AIR + ADP + Pi, Dictyostelium discoideum" xref: Reactome:REACT_83744 "FGAM + ATP => AIR + ADP + Pi, Canis familiaris" xref: Reactome:REACT_86553 "FGAM + ATP => AIR + ADP + Pi, Caenorhabditis elegans" xref: Reactome:REACT_87634 "FGAM + ATP => AIR + ADP + Pi, Rattus norvegicus" xref: Reactome:REACT_88385 "FGAM + ATP => AIR + ADP + Pi, Mycobacterium tuberculosis" xref: Reactome:REACT_89870 "FGAM + ATP => AIR + ADP + Pi, Gallus gallus" xref: Reactome:REACT_93152 "FGAM + ATP => AIR + ADP + Pi, Danio rerio" xref: Reactome:REACT_94295 "FGAM + ATP => AIR + ADP + Pi, Staphylococcus aureus N315" xref: Reactome:REACT_96653 "FGAM + ATP => AIR + ADP + Pi, Bos taurus" xref: Reactome:REACT_99755 "FGAM + ATP => AIR + ADP + Pi, Schizosaccharomyces pombe" xref: RHEA:23035 is_a: GO:0016882 ! cyclo-ligase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004643 name: phosphoribosylaminoimidazolecarboxamide formyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide." [EC:2.1.2.3] subset: gosubset_prok synonym: "10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazole-carboxamide N-formyltransferase activity" EXACT [EC:2.1.2.3] synonym: "10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity" EXACT [EC:2.1.2.3] synonym: "5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity" EXACT [EC:2.1.2.3] synonym: "5-amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase activity" EXACT [EC:2.1.2.3] synonym: "5-amino-4-imidazolecarboxamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.3] synonym: "5-amino-4-imidazolecarboxamide ribotide transformylase activity" EXACT [EC:2.1.2.3] synonym: "AICAR formyltransferase activity" EXACT [EC:2.1.2.3] synonym: "AICAR transformylase activity" EXACT [EC:2.1.2.3] synonym: "aminoimidazolecarboxamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.3] xref: EC:2.1.2.3 xref: MetaCyc:AICARTRANSFORM-RXN xref: Reactome:REACT_100136 "AICAR + 10-Formyl-THF => FAICAR + THF, Saccharomyces cerevisiae" xref: Reactome:REACT_105746 "AICAR + 10-Formyl-THF => FAICAR + THF, Gallus gallus" xref: Reactome:REACT_106017 "AICAR + 10-Formyl-THF => FAICAR + THF, Xenopus tropicalis" xref: Reactome:REACT_106129 "AICAR + 10-Formyl-THF => FAICAR + THF, Taeniopygia guttata" xref: Reactome:REACT_109989 "AICAR + 10-Formyl-THF => FAICAR + THF, Schizosaccharomyces pombe" xref: Reactome:REACT_115711 "5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate, Gallus gallus" xref: Reactome:REACT_29929 "AICAR + 10-Formyl-THF => FAICAR + THF, Oryza sativa" xref: Reactome:REACT_33070 "AICAR + 10-Formyl-THF => FAICAR + THF, Staphylococcus aureus N315" xref: Reactome:REACT_79901 "AICAR + 10-Formyl-THF => FAICAR + THF, Mus musculus" xref: Reactome:REACT_812 "AICAR + 10-Formyl-THF => FAICAR + THF, Homo sapiens" xref: Reactome:REACT_82475 "AICAR + 10-Formyl-THF => FAICAR + THF, Mycobacterium tuberculosis" xref: Reactome:REACT_82717 "AICAR + 10-Formyl-THF => FAICAR + THF, Danio rerio" xref: Reactome:REACT_82943 "AICAR + 10-Formyl-THF => FAICAR + THF, Arabidopsis thaliana" xref: Reactome:REACT_83688 "AICAR + 10-Formyl-THF => FAICAR + THF, Canis familiaris" xref: Reactome:REACT_84114 "AICAR + 10-Formyl-THF => FAICAR + THF, Drosophila melanogaster" xref: Reactome:REACT_89291 "AICAR + 10-Formyl-THF => FAICAR + THF, Bos taurus" xref: Reactome:REACT_91865 "AICAR + 10-Formyl-THF => FAICAR + THF, Sus scrofa" xref: Reactome:REACT_93995 "AICAR + 10-Formyl-THF => FAICAR + THF, Escherichia coli" xref: Reactome:REACT_96335 "AICAR + 10-Formyl-THF => FAICAR + THF, Caenorhabditis elegans" xref: Reactome:REACT_97799 "AICAR + 10-Formyl-THF => FAICAR + THF, Rattus norvegicus" xref: Reactome:REACT_98007 "AICAR + 10-Formyl-THF => FAICAR + THF, Dictyostelium discoideum" xref: RHEA:22195 is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004651 name: polynucleotide 5'-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate." [EC:3.1.3.33] synonym: "5'-polynucleotidase activity" EXACT [EC:3.1.3.33] synonym: "polynucleotide 5'-phosphohydrolase activity" EXACT [EC:3.1.3.33] synonym: "polynucleotide 5'-triphosphatase activity" EXACT [EC:3.1.3.33] xref: EC:3.1.3.33 xref: MetaCyc:POLYNUCLEOTIDE-5-PHOSPHATASE-RXN xref: Reactome:REACT_105600 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme, Xenopus tropicalis" xref: Reactome:REACT_1368 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme, Homo sapiens" xref: Reactome:REACT_29083 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme, Danio rerio" xref: Reactome:REACT_29917 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme, Saccharomyces cerevisiae" xref: Reactome:REACT_30977 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme, Schizosaccharomyces pombe" xref: Reactome:REACT_31847 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme, Rattus norvegicus" xref: Reactome:REACT_78922 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme, Caenorhabditis elegans" xref: Reactome:REACT_79151 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme, Mus musculus" xref: Reactome:REACT_81068 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme, Drosophila melanogaster" xref: Reactome:REACT_81973 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme, Dictyostelium discoideum" xref: Reactome:REACT_82462 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme, Gallus gallus" xref: Reactome:REACT_84900 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme, Bos taurus" xref: Reactome:REACT_85239 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme, Arabidopsis thaliana" xref: Reactome:REACT_92870 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme, Canis familiaris" xref: Reactome:REACT_94470 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme, Oryza sativa" is_a: GO:0098518 ! polynucleotide phosphatase activity relationship: part_of GO:0098507 ! polynucleotide 5' dephosphorylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004659 name: prenyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor)." [GOC:mah] subset: gosubset_prok xref: EC:2.5.1.- xref: MetaCyc:GPPSYN-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004660 name: protein farnesyltransferase activity namespace: molecular_function alt_id: GO:0018223 def: "Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate." [EC:2.5.1.58, PMID:8621375] comment: The catalyzed reaction transfers a farnesyl group from farnesyl diphosphate to a target protein. There is no relationship between this activity and farnesyltransferase activity, GO:0004311, where the catalyzed reaction forms (free) geranylgeranyl diphosphate. synonym: "CAAX farnesyltransferase activity" NARROW [EC:2.5.1.58] synonym: "farnesyl-diphosphate:protein-cysteine farnesyltransferase activity" EXACT [EC:2.5.1.58] synonym: "FTase activity" EXACT [EC:2.5.1.58] synonym: "protein-cysteine farnesyltransferase activity" EXACT [] xref: EC:2.5.1.58 xref: MetaCyc:2.5.1.58-RXN is_a: GO:0008318 ! protein prenyltransferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004661 name: protein geranylgeranyltransferase activity namespace: molecular_function alt_id: GO:0018224 def: "Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein." [PMID:8621375] synonym: "protein-cysteine geranylgeranyltransferase activity" EXACT [] xref: EC:2.5.1.- is_a: GO:0008318 ! protein prenyltransferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004662 name: CAAX-protein geranylgeranyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families." [EC:2.5.1.59, PMID:8621375] synonym: "geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity" EXACT [] synonym: "geranylgeranyltransferase type I activity" EXACT [] synonym: "GGTase-I activity" EXACT [] synonym: "GGTaseI activity" EXACT [] synonym: "protein geranylgeranyltransferase type I" RELATED [EC:2.5.1.59] synonym: "type I protein geranyl-geranyltransferase activity" EXACT [EC:2.5.1.59] xref: EC:2.5.1.59 xref: MetaCyc:2.5.1.60-RXN xref: MetaCyc:RXN-3701 is_a: GO:0004661 ! protein geranylgeranyltransferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004663 name: Rab geranylgeranyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family." [EC:2.5.1.60, GOC:mah, PMID:8621375] synonym: "geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity" EXACT [] synonym: "GGTase-II activity" EXACT [] synonym: "GGTaseII activity" EXACT [] synonym: "protein geranylgeranyltransferase type II activity" EXACT [] synonym: "Rab-protein geranylgeranyltransferase activity" EXACT [] synonym: "RabGGTase activity" EXACT [] synonym: "type II protein geranyl-geranyltransferase activity" EXACT [EC:2.5.1.60] xref: EC:2.5.1.60 xref: MetaCyc:2.5.1.60-RXN xref: MetaCyc:RXN-3701 is_a: GO:0004661 ! protein geranylgeranyltransferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004672 name: protein kinase activity namespace: molecular_function alt_id: GO:0050222 def: "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] comment: Note that triphosphate is used as a phosphate donor by at least one kinase. subset: goslim_aspergillus subset: goslim_candida subset: goslim_metagenomics subset: gosubset_prok synonym: "protamine kinase activity" NARROW [] xref: MetaCyc:PROTEIN-KINASE-RXN xref: Reactome:REACT_100389 "Phosphorylation and Release of IRF3 or IRF7, Bos taurus" xref: Reactome:REACT_100723 "Phosphorylation of p130Cas by SRC-FADK1 complex, Canis familiaris" xref: Reactome:REACT_100866 "Phosphorylation and activation of Ezrin, Gallus gallus" xref: Reactome:REACT_101171 "Phosphorylation and release of IRF3/IRF7, Rattus norvegicus" xref: Reactome:REACT_101316 "Autophosphorylation of FADK1 at Y397, Rattus norvegicus" xref: Reactome:REACT_102340 "Activated Src activates ERK, Danio rerio" xref: Reactome:REACT_102368 "Phosphorylation and Release of IRF3 or IRF7, Gallus gallus" xref: Reactome:REACT_104931 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Gallus gallus" xref: Reactome:REACT_104987 "Phosphorylation of pFADK1 by SRC, Danio rerio" xref: Reactome:REACT_105344 "Phosphorylation of p130Cas by SRC-FADK1 complex, Sus scrofa" xref: Reactome:REACT_106425 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Taeniopygia guttata" xref: Reactome:REACT_106633 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Sus scrofa" xref: Reactome:REACT_107161 "Phosphorylation and release of IRF3/IRF7, Taeniopygia guttata" xref: Reactome:REACT_107646 "Phosphorylation and release of IRF3/IRF7, Canis familiaris" xref: Reactome:REACT_107914 "(Frs2)Rap1-GTP binds to and activates B-Raf, Xenopus tropicalis" xref: Reactome:REACT_108319 "Activated Src activates ERK, Xenopus tropicalis" xref: Reactome:REACT_108693 "Phosphorylation and release of IRF3/IRF7, Mus musculus" xref: Reactome:REACT_109624 "Phosphorylation of p130Cas by SRC-FADK1 complex, Rattus norvegicus" xref: Reactome:REACT_110105 "Phosphorylation and activation of Ezrin, Canis familiaris" xref: Reactome:REACT_110177 "Autophosphorylation of FADK1 at Y397, Mus musculus" xref: Reactome:REACT_110248 "Activated Src activates ERK, Canis familiaris" xref: Reactome:REACT_111075 "Phosphorylation of LIN52 component of MuvB by DYRK1A, Homo sapiens" xref: Reactome:REACT_111995 "Phosphorylation of p130Cas by SRC-FADK1 complex, Drosophila melanogaster" xref: Reactome:REACT_112267 "Autophosphorylation of FADK1 at Y397, Drosophila melanogaster" xref: Reactome:REACT_112918 "Phosphorylation and activation of Ezrin, Caenorhabditis elegans" xref: Reactome:REACT_113100 "Activated Src activates ERK, Drosophila melanogaster" xref: Reactome:REACT_113334 "PKC phosphorylates GRK2, Caenorhabditis elegans" xref: Reactome:REACT_113440 "Phosphorylation and release of IRF3/IRF7, Xenopus tropicalis" xref: Reactome:REACT_113589 "Phosphorylation of pFADK1 by SRC, Drosophila melanogaster" xref: Reactome:REACT_113821 "Activated Src activates ERK, Caenorhabditis elegans" xref: Reactome:REACT_114093 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Danio rerio" xref: Reactome:REACT_114693 "Phosphorylation of pFADK1 by SRC, Xenopus tropicalis" xref: Reactome:REACT_115673 "PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR, Homo sapiens" xref: Reactome:REACT_115712 "Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers, Homo sapiens" xref: Reactome:REACT_115868 "Phosphorylation of c-Abl and Arg by ATM, Gallus gallus" xref: Reactome:REACT_116057 "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1, Homo sapiens" xref: Reactome:REACT_116116 "PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3, Homo sapiens" xref: Reactome:REACT_12050 "(Frs2)Rap1-GTP binds to and activates B-Raf, Homo sapiens" xref: Reactome:REACT_1325 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Homo sapiens" xref: Reactome:REACT_15368 "Phosphorylation of pFADK1 by SRC, Homo sapiens" xref: Reactome:REACT_15375 "Phosphorylation of p130Cas by SRC-FADK1 complex, Homo sapiens" xref: Reactome:REACT_15534 "PKC phosphorylates GRK2, Homo sapiens" xref: Reactome:REACT_15535 "Autophosphorylation of FADK1 at Y397, Homo sapiens" xref: Reactome:REACT_161 "rLkb-1 (Stk-11) activates AMPK by phosphorylation, Rattus norvegicus" xref: Reactome:REACT_1825 "INF-gamma induced phosphorylation of L13a, Homo sapiens" xref: Reactome:REACT_19374 "Phosphorylation of Plexin-A, Mus musculus" xref: Reactome:REACT_22301 "Phosphorylation and activation of Ezrin, Homo sapiens" xref: Reactome:REACT_22305 "Phosphorylation of FADK1, Mus musculus" xref: Reactome:REACT_23900 "Activated Src activates ERK, Homo sapiens" xref: Reactome:REACT_24935 "Activation of IKK by MEKK1, Homo sapiens" xref: Reactome:REACT_25200 "IRAK1 phosphorylates Pellino, Homo sapiens" xref: Reactome:REACT_25213 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:Mal:activated TLR complex, Homo sapiens" xref: Reactome:REACT_25241 "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation, Homo sapiens" xref: Reactome:REACT_25327 "Phosphorylation and release of IRF7, Homo sapiens" xref: Reactome:REACT_25368 "Phosphorylation and release of IRF3/IRF7, Homo sapiens" xref: Reactome:REACT_27151 "Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR, Homo sapiens" xref: Reactome:REACT_27163 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex, Homo sapiens" xref: Reactome:REACT_27165 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex, Homo sapiens" xref: Reactome:REACT_27228 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR, Homo sapiens" xref: Reactome:REACT_29590 "PKC phosphorylates GRK2, Rattus norvegicus" xref: Reactome:REACT_29816 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Drosophila melanogaster" xref: Reactome:REACT_30885 "Phosphorylation of p130Cas by SRC-FADK1 complex, Bos taurus" xref: Reactome:REACT_31028 "Autophosphorylation of FADK1 at Y397, Sus scrofa" xref: Reactome:REACT_31157 "Phosphorylation of pFADK1 by SRC, Canis familiaris" xref: Reactome:REACT_31403 "Autophosphorylation of FADK1 at Y397, Gallus gallus" xref: Reactome:REACT_32448 "Phosphorylation of pFADK1 by SRC, Bos taurus" xref: Reactome:REACT_32744 "PKC phosphorylates GRK2, Mus musculus" xref: Reactome:REACT_33098 "PKC phosphorylates GRK2, Canis familiaris" xref: Reactome:REACT_33973 "Phosphorylation and Release of IRF3 or IRF7, Canis familiaris" xref: Reactome:REACT_34630 "(Frs2)Rap1-GTP binds to and activates B-Raf, Danio rerio" xref: Reactome:REACT_6227 "Activated DTOR also phosphorylates D4EBP, Drosophila melanogaster" xref: Reactome:REACT_6236 "Activated DTOR phosphorylates DS6K, Drosophila melanogaster" xref: Reactome:REACT_6842 "Phosphorylation and Release of IRF3 or IRF7, Homo sapiens" xref: Reactome:REACT_6862 "Multiple IRAK1 autophosphorylation steps, Homo sapiens" xref: Reactome:REACT_72123 "PKC phosphorylates GRK2, Sus scrofa" xref: Reactome:REACT_75763 "Phosphorylation and release of IRF3, Gallus gallus" xref: Reactome:REACT_75767 "Phosphorylation of IKKs complex mediated by MEKK1, Gallus gallus" xref: Reactome:REACT_77320 "Phosphorylation and release of IRF3/IRF7, Gallus gallus" xref: Reactome:REACT_77352 "Phosphorylation of p130Cas by SRC-FADK1 complex, Danio rerio" xref: Reactome:REACT_78568 "Phosphorylation and activation of Ezrin, Danio rerio" xref: Reactome:REACT_79546 "Activated Src activates ERK, Gallus gallus" xref: Reactome:REACT_80382 "Phosphorylation and activation of Ezrin, Mus musculus" xref: Reactome:REACT_81116 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Canis familiaris" xref: Reactome:REACT_81601 "Autophosphorylation of FADK1 at Y397, Bos taurus" xref: Reactome:REACT_81960 "PKC phosphorylates GRK2, Drosophila melanogaster" xref: Reactome:REACT_82440 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Xenopus tropicalis" xref: Reactome:REACT_82942 "Activated Src activates ERK, Bos taurus" xref: Reactome:REACT_83498 "Activated Src activates ERK, Taeniopygia guttata" xref: Reactome:REACT_83992 "(Frs2)Rap1-GTP binds to and activates B-Raf, Mus musculus" xref: Reactome:REACT_84298 "Autophosphorylation of FADK1 at Y397, Danio rerio" xref: Reactome:REACT_84426 "Phosphorylation and Release of IRF3 or IRF7, Taeniopygia guttata" xref: Reactome:REACT_85334 "PKC phosphorylates GRK2, Bos taurus" xref: Reactome:REACT_85934 "Autophosphorylation of FADK1 at Y397, Canis familiaris" xref: Reactome:REACT_86784 "Autophosphorylation of FADK1 at Y397, Taeniopygia guttata" xref: Reactome:REACT_86846 "Activated Src activates ERK, Mus musculus" xref: Reactome:REACT_87050 "Phosphorylation of pFADK1 by SRC, Mus musculus" xref: Reactome:REACT_87514 "Phosphorylation and activation of Ezrin, Sus scrofa" xref: Reactome:REACT_87874 "Phosphorylation of pFADK1 by SRC, Sus scrofa" xref: Reactome:REACT_87926 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Bos taurus" xref: Reactome:REACT_88017 "PKC phosphorylates GRK2, Taeniopygia guttata" xref: Reactome:REACT_88090 "Phosphorylation and release of IRF3/IRF7, Bos taurus" xref: Reactome:REACT_88178 "Phosphorylation and release of IRF3/IRF7, Sus scrofa" xref: Reactome:REACT_88344 "(Frs2)Rap1-GTP binds to and activates B-Raf, Sus scrofa" xref: Reactome:REACT_88685 "Phosphorylation of p130Cas by SRC-FADK1 complex, Xenopus tropicalis" xref: Reactome:REACT_89390 "(Frs2)Rap1-GTP binds to and activates B-Raf, Bos taurus" xref: Reactome:REACT_90060 "Autophosphorylation of FADK1 at Y397, Xenopus tropicalis" xref: Reactome:REACT_90671 "Phosphorylation and activation of Ezrin, Xenopus tropicalis" xref: Reactome:REACT_90879 "Phosphorylation of p130Cas by SRC-FADK1 complex, Gallus gallus" xref: Reactome:REACT_91096 "Activated Src activates ERK, Sus scrofa" xref: Reactome:REACT_93160 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Mus musculus" xref: Reactome:REACT_93476 "(Frs2)Rap1-GTP binds to and activates B-Raf, Canis familiaris" xref: Reactome:REACT_93547 "Activated Src activates ERK, Rattus norvegicus" xref: Reactome:REACT_94091 "Phosphorylation and activation of Ezrin, Bos taurus" xref: Reactome:REACT_95384 "Phosphorylation and Release of IRF3 or IRF7, Mus musculus" xref: Reactome:REACT_96044 "Phosphorylation of p130Cas by SRC-FADK1 complex, Mus musculus" xref: Reactome:REACT_96155 "Phosphorylation and release of IRF3/IRF7, Danio rerio" xref: Reactome:REACT_96307 "Phosphorylation and Release of IRF3 or IRF7, Danio rerio" xref: Reactome:REACT_96320 "Phosphorylation and activation of Ezrin, Rattus norvegicus" xref: Reactome:REACT_96822 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Dictyostelium discoideum" xref: Reactome:REACT_96873 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer, Caenorhabditis elegans" xref: Reactome:REACT_97267 "PKC phosphorylates GRK2, Gallus gallus" xref: Reactome:REACT_97501 "(Frs2)Rap1-GTP binds to and activates B-Raf, Taeniopygia guttata" xref: Reactome:REACT_97784 "Phosphorylation and activation of Ezrin, Taeniopygia guttata" xref: Reactome:REACT_98334 "Phosphorylation of pFADK1 by SRC, Rattus norvegicus" xref: Reactome:REACT_98994 "(Frs2)Rap1-GTP binds to and activates B-Raf, Gallus gallus" xref: Reactome:REACT_99274 "Phosphorylation of p130Cas by SRC-FADK1 complex, Taeniopygia guttata" is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor relationship: part_of GO:0006468 ! protein phosphorylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004674 name: protein serine/threonine kinase activity namespace: molecular_function alt_id: GO:0004695 alt_id: GO:0004696 alt_id: GO:0004700 def: "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] subset: gosubset_prok synonym: "protein kinase (phosphorylating) activity" NARROW [EC:2.7.11.1] synonym: "protein phosphokinase activity" NARROW [EC:2.7.11.1] synonym: "protein serine kinase activity" NARROW [EC:2.7.11.1] synonym: "protein serine-threonine kinase activity" EXACT [EC:2.7.11.1] synonym: "protein-serine kinase activity" NARROW [EC:2.7.11.1] synonym: "serine kinase activity" NARROW [EC:2.7.11.1] synonym: "serine protein kinase activity" NARROW [EC:2.7.11.1] synonym: "serine(threonine) protein kinase activity" EXACT [EC:2.7.11.1] synonym: "serine-specific protein kinase activity" NARROW [EC:2.7.11.1] synonym: "serine/threonine protein kinase activity" EXACT [EC:2.7.11.1] synonym: "threonine-specific protein kinase activity" NARROW [EC:2.7.11.1] xref: EC:2.7.11 xref: Reactome:REACT_100117 "Phosphorylation of eIF2-alpha by PERK, Xenopus tropicalis" xref: Reactome:REACT_100192 "AKT phosphorylates IKKalpha, Canis familiaris" xref: Reactome:REACT_100209 "ERK1/2/5 activate RSK1/2/3, Canis familiaris" xref: Reactome:REACT_100224 "Activation of cytosolic AMPK by phosphorylation, Bos taurus" xref: Reactome:REACT_100446 "Activation of cytosolic AMPK by phosphorylation, Rattus norvegicus" xref: Reactome:REACT_100588 "ERK5 activates the transcription factor MEF2, Xenopus tropicalis" xref: Reactome:REACT_100590 "AKT phosphorylates IKKalpha, Xenopus tropicalis" xref: Reactome:REACT_100784 "AKT phosphorylates IKKalpha, Rattus norvegicus" xref: Reactome:REACT_100870 "Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex, Bos taurus" xref: Reactome:REACT_100918 "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding, Mus musculus" xref: Reactome:REACT_100989 "Autophosphorylation of IRE1 dimer, Saccharomyces cerevisiae" xref: Reactome:REACT_101264 "Phosphorylated MAPKs phosphorylate ATF-2, Sus scrofa" xref: Reactome:REACT_101280 "Activation of claspin, Xenopus tropicalis" xref: Reactome:REACT_101291 "Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex, Danio rerio" xref: Reactome:REACT_101497 "Activation of claspin, Bos taurus" xref: Reactome:REACT_101896 "ERK1/2 phosphorylates MSK1, Canis familiaris" xref: Reactome:REACT_101920 "Inactivation of MEK1 by p34cdc2, Drosophila melanogaster" xref: Reactome:REACT_101930 "Inactivation of MEK1 by p34cdc2, Caenorhabditis elegans" xref: Reactome:REACT_102053 "MEK1 phosphorylates ERK-1, Saccharomyces cerevisiae" xref: Reactome:REACT_102074 "AKT phosphorylates caspase-9, Mus musculus" xref: Reactome:REACT_102078 "Phosphorylation of Cdc25C at Ser 216 by Chk1, Canis familiaris" xref: Reactome:REACT_102096 "Activation of cytosolic AMPK by phosphorylation, Gallus gallus" xref: Reactome:REACT_102133 "Phosphorylated MAPKs phosphorylate ATF-2, Mus musculus" xref: Reactome:REACT_102370 "AKT can phosphorylate NUR77, Mus musculus" xref: Reactome:REACT_102455 "Active p38 MAPK phosphorylates MAPKAPK2 or 3, Canis familiaris" xref: Reactome:REACT_102500 "AKT can phosphorylate RSK, Rattus norvegicus" xref: Reactome:REACT_102718 "Active p38 MAPK phosphorylates MAPKAPK2 or 3, Bos taurus" xref: Reactome:REACT_102778 "ERK1/2/5 activate RSK1/2/3, Gallus gallus" xref: Reactome:REACT_102791 "Activation of NF-kB complex, Xenopus tropicalis" xref: Reactome:REACT_102943 "Phosphorylated MAPKs phosphorylate ATF-2, Rattus norvegicus" xref: Reactome:REACT_102975 "LIM kinase phosphorylation by ROCK, Danio rerio" xref: Reactome:REACT_103109 "Phosphorylation of CRMPs by Cdk5, Xenopus tropicalis" xref: Reactome:REACT_103162 "Myosin regulatory light chain phosphorylation by ROCK, Xenopus tropicalis" xref: Reactome:REACT_103217 "Phosphorylation of PKC theta, Xenopus tropicalis" xref: Reactome:REACT_103304 "Phosphorylation of FANCI by ATM/ATR, Danio rerio" xref: Reactome:REACT_103449 "PDK1 phosphorylates AKT at T308, Caenorhabditis elegans" xref: Reactome:REACT_103541 "Activated TAK1 mediates phosphorylation of the IKK Complex, Sus scrofa" xref: Reactome:REACT_103596 "MEK1 phosphorylates ERK-1, Bos taurus" xref: Reactome:REACT_103658 "Phosphorylation of MARCKS by Protein kinase C, alpha type, Bos taurus" xref: Reactome:REACT_103882 "Phosphorylation of CRY and PER Proteins, Sus scrofa" xref: Reactome:REACT_104102 "Active p38 MAPK phosphorylates MAPKAPK2 or 3, Mus musculus" xref: Reactome:REACT_104121 "LIM kinase phosphorylation by ROCK, Drosophila melanogaster" xref: Reactome:REACT_104145 "PDK1 phosphorylates AKT at T308, Canis familiaris" xref: Reactome:REACT_104284 "Active p38 MAPK phosphorylates MAPKAPK2 or 3, Xenopus tropicalis" xref: Reactome:REACT_104288 "Phosphorylation of FANCI by ATM/ATR, Drosophila melanogaster" xref: Reactome:REACT_104416 "ERK1/2 activates ELK1, Canis familiaris" xref: Reactome:REACT_104521 "MEK1 phosphorylates ERK-1, Mus musculus" xref: Reactome:REACT_104525 "Phosphorylation of PKC theta, Taeniopygia guttata" xref: Reactome:REACT_104547 "Recruitment and activation of Chk1, Gallus gallus" xref: Reactome:REACT_104549 "Phosphorylation of Bcl10, Gallus gallus" xref: Reactome:REACT_104564 "AKT phosphorylates caspase-9, Bos taurus" xref: Reactome:REACT_104874 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9, Mus musculus" xref: Reactome:REACT_104906 "Myosin regulatory light chain phosphorylation by ROCK, Mus musculus" xref: Reactome:REACT_104932 "AKT can phosphorylate NUR77, Canis familiaris" xref: Reactome:REACT_104985 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP, Rattus norvegicus" xref: Reactome:REACT_105016 "p38MAPK phosphorylates MSK1, Saccharomyces cerevisiae" xref: Reactome:REACT_105038 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP, Sus scrofa" xref: Reactome:REACT_105077 "Phosphorylation of MARCKS by Protein kinase C, alpha type, Mus musculus" xref: Reactome:REACT_105298 "Activation of IKK complex, Danio rerio" xref: Reactome:REACT_105447 "Phosphorylation of CARMA1, Xenopus tropicalis" xref: Reactome:REACT_105470 "Phosphorylation of FANCD2 by ATR/ATM, Gallus gallus" xref: Reactome:REACT_105502 "AKT interacts and phosphorylates Cot, Taeniopygia guttata" xref: Reactome:REACT_105534 "p38MAPK phosphorylates MSK1, Drosophila melanogaster" xref: Reactome:REACT_105602 "MSK1 activates CREB, Sus scrofa" xref: Reactome:REACT_105625 "AKT can phosphorylate forkhead box transcription factors, Canis familiaris" xref: Reactome:REACT_105894 "PKA phosphorylates CREB, Canis familiaris" xref: Reactome:REACT_106015 "Phosphorylation of Bcl10, Bos taurus" xref: Reactome:REACT_106033 "ERK1/2/5 activate RSK1/2/3, Danio rerio" xref: Reactome:REACT_106141 "AKT phosphorylates IKKalpha, Bos taurus" xref: Reactome:REACT_106200 "PKA phosphorylates CREB, Danio rerio" xref: Reactome:REACT_106255 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP, Mus musculus" xref: Reactome:REACT_106263 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9, Bos taurus" xref: Reactome:REACT_106338 "ERK1/2/5 activate RSK1/2/3, Xenopus tropicalis" xref: Reactome:REACT_106350 "Phosphorylation of CRY and PER Proteins, Xenopus tropicalis" xref: Reactome:REACT_106414 "CERT + ATP => monophospho-CERT + ADP, Taeniopygia guttata" xref: Reactome:REACT_106418 "IRAK is activated, Canis familiaris" xref: Reactome:REACT_106434 "Activation of claspin, Canis familiaris" xref: Reactome:REACT_106501 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9, Canis familiaris" xref: Reactome:REACT_106556 "Activation of TAK1-TAB2 complex, Xenopus tropicalis" xref: Reactome:REACT_106557 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9, Taeniopygia guttata" xref: Reactome:REACT_106566 "Phosphorylation of CARMA1, Rattus norvegicus" xref: Reactome:REACT_106589 "MEK1 phosphorylates ERK-1, Schizosaccharomyces pombe" xref: Reactome:REACT_106643 "Autophosphorylation of IRE1 dimer, Danio rerio" xref: Reactome:REACT_106685 "Myosin regulatory light chain phosphorylation by ROCK, Rattus norvegicus" xref: Reactome:REACT_106700 "AKT phosphorylates PRAS40, Rattus norvegicus" xref: Reactome:REACT_106730 "Phosphorylation of Cdc25C at Ser 216 by Chk1, Mus musculus" xref: Reactome:REACT_106732 "Recruitment and activation of Chk1, Canis familiaris" xref: Reactome:REACT_106789 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9, Rattus norvegicus" xref: Reactome:REACT_106853 "Phosphorylation of MARCKS by Protein kinase C, alpha type, Rattus norvegicus" xref: Reactome:REACT_106862 "Phosphorylation of MARCKS by Protein kinase C, alpha type, Xenopus tropicalis" xref: Reactome:REACT_106985 "Phosphorylation of LIMK-1 by PAK, Danio rerio" xref: Reactome:REACT_107087 "IKKbeta is activated, Bos taurus" xref: Reactome:REACT_107170 "Phosphorylation of cofilin by LIMK-1, Canis familiaris" xref: Reactome:REACT_107216 "MSK1 activates CREB, Rattus norvegicus" xref: Reactome:REACT_107249 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9, Danio rerio" xref: Reactome:REACT_107265 "Phosphorylation of eIF2-alpha by PERK, Bos taurus" xref: Reactome:REACT_107488 "Phosphorylation of L1 by p90rsk, Gallus gallus" xref: Reactome:REACT_107608 "Phosphorylation of CRMPs by GSK3beta, Sus scrofa" xref: Reactome:REACT_107764 "Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex, Rattus norvegicus" xref: Reactome:REACT_107768 "Transphosphorylation of pLIMK1, Mus musculus" xref: Reactome:REACT_107779 "AKT phosphorylates p21Cip1 and p27Kip1, Rattus norvegicus" xref: Reactome:REACT_107780 "TORC2 (mTOR) phosphorylates AKT at S473, Canis familiaris" xref: Reactome:REACT_1078 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP, Homo sapiens" xref: Reactome:REACT_108016 "ALOX5 is phosphorylated by MAPKAP2, Gallus gallus" xref: Reactome:REACT_108133 "Active p38 MAPK phosphorylates MAPKAPK2 or 3, Rattus norvegicus" xref: Reactome:REACT_108154 "Phosphorylation of FANCD2 by ATR/ATM, Oryza sativa" xref: Reactome:REACT_108328 "Phosphorylation of CRMPs by GSK3beta, Bos taurus" xref: Reactome:REACT_108433 "Autophosphorylation of PAK, Taeniopygia guttata" xref: Reactome:REACT_108435 "CERT + ATP => monophospho-CERT + ADP, Gallus gallus" xref: Reactome:REACT_108461 "Recruitment and activation of Chk1, Bos taurus" xref: Reactome:REACT_108511 "p38MAPK phosphorylates MSK1, Danio rerio" xref: Reactome:REACT_108538 "MAPKAPK2 phosphorylates CREB at Serine 133, Sus scrofa" xref: Reactome:REACT_108605 "PKA phosphorylates CREB, Mus musculus" xref: Reactome:REACT_108670 "MEK2 phosphorylates ERK-2, Gallus gallus" xref: Reactome:REACT_108671 "ALOX5 is phosphorylated by MAPKAP2, Mus musculus" xref: Reactome:REACT_108839 "Transphosphorylation of pLIMK1, Dictyostelium discoideum" xref: Reactome:REACT_108994 "Phosphorylation of cPLA2 by MAPK p38 alpha, Taeniopygia guttata" xref: Reactome:REACT_109076 "MEK2 phosphorylates ERK-2, Danio rerio" xref: Reactome:REACT_109135 "Active p38 MAPK phosphorylates MAPKAPK2 or 3, Taeniopygia guttata" xref: Reactome:REACT_109768 "Phosphorylation of Cdc25C at Ser 216 by Chk1, Rattus norvegicus" xref: Reactome:REACT_109859 "p38MAPK phosphorylates MSK1, Mus musculus" xref: Reactome:REACT_110031 "Phosphorylation of L1 by p90rsk, Danio rerio" xref: Reactome:REACT_110083 "Autophosphorylation of PAK, Gallus gallus" xref: Reactome:REACT_110087 "MAPKAPK2 phosphorylates CREB at Serine 133, Bos taurus" xref: Reactome:REACT_110094 "AKT can phosphorylate RSK, Taeniopygia guttata" xref: Reactome:REACT_110138 "Inactivation of MEK1 by p34cdc2, Taeniopygia guttata" xref: Reactome:REACT_110166 "AKT can phosphorylate forkhead box transcription factors, Xenopus tropicalis" xref: Reactome:REACT_110216 "ERK1/2 phosphorylates MSK1, Mus musculus" xref: Reactome:REACT_110270 "Autophosphorylation of IRE1 dimer, Canis familiaris" xref: Reactome:REACT_110312 "Phosphorylation of FANCI by ATM/ATR, Mus musculus" xref: Reactome:REACT_110374 "Phosphorylated MAPKs phosphorylate ATF-2, Gallus gallus" xref: Reactome:REACT_110431 "Phosphorylation of FANCD2 by ATR/ATM, Sus scrofa" xref: Reactome:REACT_110457 "Myosin regulatory light chain phosphorylation by ROCK, Danio rerio" xref: Reactome:REACT_110470 "Phosphorylation of L1 by p90rsk, Canis familiaris" xref: Reactome:REACT_110479 "AKT phosphorylates TSC2, inhibiting it, Mus musculus" xref: Reactome:REACT_110532 "Inactivation of MEK1 by p34cdc2, Danio rerio" xref: Reactome:REACT_110554 "MEK1 phosphorylates ERK-1, Drosophila melanogaster" xref: Reactome:REACT_110695 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP, Caenorhabditis elegans" xref: Reactome:REACT_110719 "Phosphorylation of CARMA1, Gallus gallus" xref: Reactome:REACT_110757 "Autophosphorylation of PAK, Rattus norvegicus" xref: Reactome:REACT_110789 "MAP kinase activates MAPKAPK2, MAPKAPK3 and MSK1, Sus scrofa" xref: Reactome:REACT_110890 "Phosphorylation of cPLA2 by MAPK p38 alpha, Danio rerio" xref: Reactome:REACT_110921 "Activation of TAK1-TAB2 complex, Sus scrofa" xref: Reactome:REACT_110930 "ERK1/2 phosphorylates MSK1, Saccharomyces cerevisiae" xref: Reactome:REACT_111058 "Phosphorylation of Smad2 by Nodal Receptor, Homo sapiens" xref: Reactome:REACT_111063 "SPRY2 is phosphorylated by phosphorylated MNK1, Homo sapiens" xref: Reactome:REACT_111068 "ACVR2A/B (ActRIIA/B) Phosphorylates ACVR1B (ActRIB, ALK4) in Response to Activin, Homo sapiens" xref: Reactome:REACT_111117 "p-MEK phosphorylates ERK, Homo sapiens" xref: Reactome:REACT_111130 "Type II Activin Receptor (ActRIIB/ACVR2B) Phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in Response to NODAL, Homo sapiens" xref: Reactome:REACT_111131 "Type II Activin Receptor (ActRII/ACVR2) Phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in Response to NODAL, Homo sapiens" xref: Reactome:REACT_111138 "Phosphorylation of R-SMAD2/3 by NODAL Receptor, Homo sapiens" xref: Reactome:REACT_111196 "PKC alpha interacts with and phosphorylates KIT, Homo sapiens" xref: Reactome:REACT_11174 "Phosphorylation of Cyclin D1 on Thr-286 by GSK-3 beta, Mus musculus" xref: Reactome:REACT_11183 "Activation of cytosolic AMPK by phosphorylation, Homo sapiens" xref: Reactome:REACT_111939 "Activated TAK1 mediates phosphorylation of the IKK Complex, Xenopus tropicalis" xref: Reactome:REACT_111972 "Autophosphorylation of IRE1 dimer, Arabidopsis thaliana" xref: Reactome:REACT_112003 "Phosphorylation of PKC theta, Saccharomyces cerevisiae" xref: Reactome:REACT_112061 "Phosphorylation of Cdc25C at Ser 216 by Chk1, Schizosaccharomyces pombe" xref: Reactome:REACT_112107 "AKT phosphorylates caspase-9, Gallus gallus" xref: Reactome:REACT_112321 "Phosphorylation of L1 by p90rsk, Schizosaccharomyces pombe" xref: Reactome:REACT_112392 "AKT phosphorylates FOXO1A, Canis familiaris" xref: Reactome:REACT_112393 "AKT phosphorylates p21Cip1 and p27Kip1, Gallus gallus" xref: Reactome:REACT_112404 "Inactivation of MEK1 by p34cdc2, Saccharomyces cerevisiae" xref: Reactome:REACT_112488 "Inactivation of MEK1 by p34cdc2, Schizosaccharomyces pombe" xref: Reactome:REACT_112501 "Phosphorylation of L1 by p90rsk, Saccharomyces cerevisiae" xref: Reactome:REACT_112505 "TORC2 (mTOR) phosphorylates AKT at S473, Schizosaccharomyces pombe" xref: Reactome:REACT_112514 "Activation of IKK complex, Xenopus tropicalis" xref: Reactome:REACT_112516 "TORC2 (mTOR) phosphorylates AKT at S473, Saccharomyces cerevisiae" xref: Reactome:REACT_112550 "AKT phosphorylates GSK3, Schizosaccharomyces pombe" xref: Reactome:REACT_112561 "AKT phosphorylates FOXO1A, Bos taurus" xref: Reactome:REACT_112583 "AKT phosphorylates GSK3, Gallus gallus" xref: Reactome:REACT_112607 "AKT can phosphorylate RSK, Schizosaccharomyces pombe" xref: Reactome:REACT_112628 "AKT phosphorylates FOXO1A, Taeniopygia guttata" xref: Reactome:REACT_112928 "Autophosphorylation of IRE1 dimer, Xenopus tropicalis" xref: Reactome:REACT_112965 "AKT can phosphorylate RSK, Saccharomyces cerevisiae" xref: Reactome:REACT_113006 "ERK1/2 phosphorylates MSK1, Oryza sativa" xref: Reactome:REACT_113045 "AKT phosphorylates FOXO1A, Drosophila melanogaster" xref: Reactome:REACT_113059 "Autophosphorylation of IRE1 dimer, Dictyostelium discoideum" xref: Reactome:REACT_113062 "CERT + ATP => monophospho-CERT + ADP, Sus scrofa" xref: Reactome:REACT_113187 "ERK1/2 phosphorylates MSK1, Dictyostelium discoideum" xref: Reactome:REACT_113199 "Activation of NF-kB complex, Taeniopygia guttata" xref: Reactome:REACT_113389 "AKT phosphorylates FOXO1A, Mus musculus" xref: Reactome:REACT_113424 "PDK1 phosphorylates AKT at T308, Gallus gallus" xref: Reactome:REACT_113479 "ERK1/2 activates ELK1, Taeniopygia guttata" xref: Reactome:REACT_113486 "AKT phosphorylates TSC2, inhibiting it, Gallus gallus" xref: Reactome:REACT_113508 "AKT phosphorylates GSK3, Drosophila melanogaster" xref: Reactome:REACT_113549 "ERK1/2/5 activate RSK1/2/3, Oryza sativa" xref: Reactome:REACT_113560 "AKT interacts and phosphorylates Cot, Gallus gallus" xref: Reactome:REACT_113575 "MEK1 phosphorylates ERK-1, Arabidopsis thaliana" xref: Reactome:REACT_113600 "Phosphorylation of PKC theta, Schizosaccharomyces pombe" xref: Reactome:REACT_113619 "PDK1 phosphorylates AKT at T308, Saccharomyces cerevisiae" xref: Reactome:REACT_113634 "Activated TAK1 mediates phosphorylation of the IKK Complex, Drosophila melanogaster" xref: Reactome:REACT_113693 "MEK1 phosphorylates ERK-1, Oryza sativa" xref: Reactome:REACT_113717 "AKT can phosphorylate NUR77, Drosophila melanogaster" xref: Reactome:REACT_113719 "ERK1/2 phosphorylates MSK1, Schizosaccharomyces pombe" xref: Reactome:REACT_113729 "AKT phosphorylates TSC2, inhibiting it, Schizosaccharomyces pombe" xref: Reactome:REACT_113732 "p38MAPK phosphorylates MSK1, Arabidopsis thaliana" xref: Reactome:REACT_113744 "ERK1/2/5 activate RSK1/2/3, Schizosaccharomyces pombe" xref: Reactome:REACT_113764 "Phosphorylation of cofilin by LIMK-1, Danio rerio" xref: Reactome:REACT_113794 "Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex, Xenopus tropicalis" xref: Reactome:REACT_113810 "Phosphorylation of Bcl10, Xenopus tropicalis" xref: Reactome:REACT_113830 "MEK1 phosphorylates ERK-1, Dictyostelium discoideum" xref: Reactome:REACT_113835 "Transphosphorylation of pLIMK1, Taeniopygia guttata" xref: Reactome:REACT_113900 "CERT + ATP => monophospho-CERT + ADP, Caenorhabditis elegans" xref: Reactome:REACT_113949 "p38MAPK phosphorylates MSK1, Schizosaccharomyces pombe" xref: Reactome:REACT_114044 "Autophosphorylation of IRE1 dimer, Oryza sativa" xref: Reactome:REACT_114079 "PDK1 phosphorylates AKT at T308, Schizosaccharomyces pombe" xref: Reactome:REACT_114092 "AKT phosphorylates CREB, Gallus gallus" xref: Reactome:REACT_114136 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP, Caenorhabditis elegans" xref: Reactome:REACT_114306 "ERK1/2 phosphorylates MSK1, Arabidopsis thaliana" xref: Reactome:REACT_114321 "AKT phosphorylates IKKalpha, Gallus gallus" xref: Reactome:REACT_114322 "AKT phosphorylates FOXO1A, Rattus norvegicus" xref: Reactome:REACT_114335 "MSK1 activates CREB, Xenopus tropicalis" xref: Reactome:REACT_114476 "p38MAPK phosphorylates MSK1, Dictyostelium discoideum" xref: Reactome:REACT_114479 "AKT can phosphorylate NUR77, Caenorhabditis elegans" xref: Reactome:REACT_114548 "AKT phosphorylates MDM2, Gallus gallus" xref: Reactome:REACT_114581 "AKT can phosphorylate forkhead box transcription factors, Gallus gallus" xref: Reactome:REACT_114650 "ERK1/2 phosphorylates MSK1, Xenopus tropicalis" xref: Reactome:REACT_114660 "ERK1/2 activates ELK1, Xenopus tropicalis" xref: Reactome:REACT_114718 "ERK1/2 activates ELK1, Caenorhabditis elegans" xref: Reactome:REACT_114782 "ERK1/2/5 activate RSK1/2/3, Dictyostelium discoideum" xref: Reactome:REACT_114835 "AKT can phosphorylate forkhead box transcription factors, Drosophila melanogaster" xref: Reactome:REACT_114899 "MSK1 activates ATF1, Xenopus tropicalis" xref: Reactome:REACT_114971 "Phosphorylation of MARCKS by Protein kinase C, alpha type, Drosophila melanogaster" xref: Reactome:REACT_115073 "TORC2 (mTOR) phosphorylates AKT at S473, Gallus gallus" xref: Reactome:REACT_115253 "p38MAPK phosphorylates MSK1, Xenopus tropicalis" xref: Reactome:REACT_115290 "p38MAPK phosphorylates MSK1, Oryza sativa" xref: Reactome:REACT_115293 "Phosphorylation of Cdc25C at Ser 216 by Chk1, Saccharomyces cerevisiae" xref: Reactome:REACT_115340 "AKT phosphorylates FOXO1A, Gallus gallus" xref: Reactome:REACT_115364 "CERT + ATP => monophospho-CERT + ADP, Drosophila melanogaster" xref: Reactome:REACT_115391 "ERK1/2/5 activate RSK1/2/3, Arabidopsis thaliana" xref: Reactome:REACT_115462 "Phosphorylation of Cdc25C at Ser 216 by Chk1, Caenorhabditis elegans" xref: Reactome:REACT_115474 "AKT phosphorylates BAD, Xenopus tropicalis" xref: Reactome:REACT_115576 "Phosphorylation of NBS1 by ATM, Gallus gallus" xref: Reactome:REACT_115647 "Phosphorylation of FANCG at S7, Gallus gallus" xref: Reactome:REACT_115840 "Phosphorylation of Chk1 by ATM upon DNA damage, Gallus gallus" xref: Reactome:REACT_115981 "Phosphorylation of RPA2 by CDC2 kinase, Gallus gallus" xref: Reactome:REACT_115987 "Phosphorylation of Chk1 by ATR, Gallus gallus" xref: Reactome:REACT_116006 "PKA phosphorylates CREB, Rattus norvegicus" xref: Reactome:REACT_116016 "Phosphorylation of Chk2 by ATM upon DNA damage, Gallus gallus" xref: Reactome:REACT_116065 "Phosphorylation of USP8 by P-AKT, Homo sapiens" xref: Reactome:REACT_1170 "Phosphorylation of Cdc25C at Ser 216 by Chk1, Homo sapiens" xref: Reactome:REACT_12032 "MAP kinase activates MAPKAPK2, MAPKAPK3 and MSK1, Homo sapiens" xref: Reactome:REACT_12383 "AKT phosphorylates PRAS40, Homo sapiens" xref: Reactome:REACT_12391 "TORC2 (mTOR) phosphorylates AKT at S473, Homo sapiens" xref: Reactome:REACT_12395 "AKT phosphorylates caspase-9, Homo sapiens" xref: Reactome:REACT_12399 "Activation of NF-kB complex, Homo sapiens" xref: Reactome:REACT_12406 "ERK1/2 activates ELK1, Homo sapiens" xref: Reactome:REACT_12413 "ERK5 activates the transcription factor MEF2, Homo sapiens" xref: Reactome:REACT_12416 "ERK1/2 activates ELK1, Mus musculus" xref: Reactome:REACT_12420 "AKT phosphorylates p21Cip1 and p27Kip1, Homo sapiens" xref: Reactome:REACT_12429 "Akt1 phosphorylates GSK3, Rattus norvegicus" xref: Reactome:REACT_12430 "AKT phosphorylates FOXO1A, Homo sapiens" xref: Reactome:REACT_12437 "MSK1 activates ATF1, Homo sapiens" xref: Reactome:REACT_12461 "AKT phosphorylates IKKalpha, Homo sapiens" xref: Reactome:REACT_12485 "AKT can phosphorylate RSK, Homo sapiens" xref: Reactome:REACT_12487 "ERK1/2/5 activate RSK1/2/3, Homo sapiens" xref: Reactome:REACT_12518 "Activation of TAK1-TAB2 complex, Homo sapiens" xref: Reactome:REACT_12532 "AKT phosphorylates TSC2, inhibiting it, Homo sapiens" xref: Reactome:REACT_12537 "AKT phosphorylates MDM2, Homo sapiens" xref: Reactome:REACT_12546 "p38MAPK phosphorylates MSK1, Homo sapiens" xref: Reactome:REACT_12549 "AKT phosphorylates GSK3, Homo sapiens" xref: Reactome:REACT_12557 "Phosphorylation of PKC theta, Homo sapiens" xref: Reactome:REACT_12565 "AKT phosphorylates BAD, Homo sapiens" xref: Reactome:REACT_12572 "AKT can phosphorylate forkhead box transcription factors, Homo sapiens" xref: Reactome:REACT_12573 "Phosphorylation of CARMA1, Homo sapiens" xref: Reactome:REACT_12576 "ERK1/2 phosphorylates MSK1, Homo sapiens" xref: Reactome:REACT_12581 "Activation of IKK complex, Homo sapiens" xref: Reactome:REACT_12584 "PDK1 phosphorylates AKT at T308, Homo sapiens" xref: Reactome:REACT_12586 "MAPKAPK2 phosphorylates CREB at Serine 133, Homo sapiens" xref: Reactome:REACT_12597 "AKT phosphorylates CREB, Homo sapiens" xref: Reactome:REACT_12614 "AKT can phosphorylate NUR77, Homo sapiens" xref: Reactome:REACT_12619 "Phosphorylation of Bcl10, Homo sapiens" xref: Reactome:REACT_12622 "RSK1/2/3 phosphorylates CREB at Serine 133, Homo sapiens" xref: Reactome:REACT_12625 "ERK5 activates the transcription factor MEF2, Rattus norvegicus" xref: Reactome:REACT_12631 "MSK1 activates CREB, Homo sapiens" xref: Reactome:REACT_13421 "Irak is activated, Rattus norvegicus" xref: Reactome:REACT_13502 "IKKbeta phosphorylates IkB causing NF-kB to dissociate, Homo sapiens" xref: Reactome:REACT_136 "MEK1 phosphorylates ERK-1, Homo sapiens" xref: Reactome:REACT_13726 "IKKbeta is activated, Homo sapiens" xref: Reactome:REACT_13775 "IRAK is activated, Homo sapiens" xref: Reactome:REACT_1469 "perilipin + 3 ATP -> phosphorylated perilipin + 3 ADP, Rattus norvegicus" xref: Reactome:REACT_15377 "PKA phosphorylates CREB, Homo sapiens" xref: Reactome:REACT_1621 "perilipin + 3 ATP -> phosphorylated perilipin + 3 ADP, Mus musculus" xref: Reactome:REACT_1734 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP, Homo sapiens" xref: Reactome:REACT_18263 "Phosphorylation of MARCKS by Protein kinase C, alpha type, Homo sapiens" xref: Reactome:REACT_18275 "Phosphorylation of eIF2-alpha by PERK, Homo sapiens" xref: Reactome:REACT_18293 "Phosphorylation of FANCD2 by ATR/ATM, Homo sapiens" xref: Reactome:REACT_18335 "Phosphorylation of FANCI by ATM/ATR, Homo sapiens" xref: Reactome:REACT_1836 "Inactivation of MEK1 by p34cdc2, Homo sapiens" xref: Reactome:REACT_18399 "Autophosphorylation of IRE1 dimer, Homo sapiens" xref: Reactome:REACT_19152 "CERT + ATP => monophospho-CERT + ADP, Homo sapiens" xref: Reactome:REACT_19154 "Myosin regulatory light chain phosphorylation by Rock2, Gallus gallus" xref: Reactome:REACT_19156 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP, Homo sapiens" xref: Reactome:REACT_19168 "Transphosphorylation of pLIMK1, Homo sapiens" xref: Reactome:REACT_19191 "Myosin regulatory light chain phosphorylation by ROCK, Homo sapiens" xref: Reactome:REACT_19197 "Autophosphorylation of PAK, Homo sapiens" xref: Reactome:REACT_19221 "Phosphorylation of LIMK-1 by PAK, Homo sapiens" xref: Reactome:REACT_19232 "AKT interacts and phosphorylates Cot, Homo sapiens" xref: Reactome:REACT_19276 "Phosphorylation of cofilin by LIMK-1, Homo sapiens" xref: Reactome:REACT_19282 "LIM kinase phosphorylation by ROCK, Homo sapiens" xref: Reactome:REACT_19285 "Phosphorylation of CRMPs by Cdk5, Homo sapiens" xref: Reactome:REACT_19311 "ROCK1 activates LIM kinase 2 (rat), Homo sapiens" xref: Reactome:REACT_19321 "Phosphorylation of CRMPs by GSK3beta, Homo sapiens" xref: Reactome:REACT_19361 "Phosphorylation of cofilin by LIMK-1, Mus musculus" xref: Reactome:REACT_20541 "Phosphorylation of cPLA2 by MAPK p38 alpha, Homo sapiens" xref: Reactome:REACT_21251 "c-FOS activation by phospho ERK1/2, Homo sapiens" xref: Reactome:REACT_21276 "Phosphorylation of MEF2 proteins by p38, Homo sapiens" xref: Reactome:REACT_21321 "Phosphorylation of E proteins by p38 MAPK, Homo sapiens" xref: Reactome:REACT_21334 "Phosphorylation of E47 by p38 MAPK, Mus musculus" xref: Reactome:REACT_21338 "activated human TAK1 phosphorylates MKK3/MKK6, Homo sapiens" xref: Reactome:REACT_21367 "Activated TAK1 phosphorylates MKK4/MKK7, Homo sapiens" xref: Reactome:REACT_21375 "Active p38 MAPK phosphorylates MAPKAPK2 or 3, Homo sapiens" xref: Reactome:REACT_22101 "Phosphorylation of L1 by p90rsk, Homo sapiens" xref: Reactome:REACT_22105 "ALOX5 is phosphorylated by MAPKAP2, Homo sapiens" xref: Reactome:REACT_22125 "IRAK4 phosphorylates IRAK1, Homo sapiens" xref: Reactome:REACT_22162 "IRAK4-activated IRAK1 autophosphorylates, Homo sapiens" xref: Reactome:REACT_22240 "Phosphorylation of L1 by p90rsk, Homo sapiens" xref: Reactome:REACT_22325 "IRAK1 and 4 can phosphorylate Pellino-1 and 2., Homo sapiens" xref: Reactome:REACT_22371 "Interaction of PAK1 with Rac1-GTP, Homo sapiens" xref: Reactome:REACT_2247 "MEK2 phosphorylates ERK-2, Homo sapiens" xref: Reactome:REACT_23849 "PKA/PKG phosphorylate Rap1GAP2, Homo sapiens" xref: Reactome:REACT_24004 "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding, Homo sapiens" xref: Reactome:REACT_24917 "Phosphorylation of MKK4 by activated TAK1, Gallus gallus" xref: Reactome:REACT_24948 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9, Homo sapiens" xref: Reactome:REACT_24965 "Phosphorylation of KSRP by MAP kinase p38, Homo sapiens" xref: Reactome:REACT_25002 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9, Homo sapiens" xref: Reactome:REACT_25011 "IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9, Homo sapiens" xref: Reactome:REACT_25016 "Phosphorylation of HuR by PKCalpha, Homo sapiens" xref: Reactome:REACT_25040 "Activation of recruited TAK1, Gallus gallus" xref: Reactome:REACT_25086 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9, Homo sapiens" xref: Reactome:REACT_25096 "activated MEK2 phosphorylates ERK2, Gallus gallus" xref: Reactome:REACT_25097 "IRAK4 autophosphorylation in the complex with activated TLR:MyD88:Mal, Homo sapiens" xref: Reactome:REACT_25125 "Phosphorylation of CRY and PER Proteins, Homo sapiens" xref: Reactome:REACT_25161 "phosphorylation of IRAK2 by activated IRAK4, Gallus gallus" xref: Reactome:REACT_25171 "Phosphorylation of Tristetraproline (TTP) by MK2, Homo sapiens" xref: Reactome:REACT_25174 "Phosphorylation of IKKs complex by activated TAK1, Gallus gallus" xref: Reactome:REACT_25184 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9, Homo sapiens" xref: Reactome:REACT_25187 "Phosphorylation of KSRP by Protein Kinase B/Akt, Homo sapiens" xref: Reactome:REACT_25189 "chicken RIP1 facilitates IKKs complex activation, Gallus gallus" xref: Reactome:REACT_25202 "Phosphorylation of HuR by PKCdelta, Homo sapiens" xref: Reactome:REACT_25204 "activated IKKs phosphorylates IkB alpha causing the NFkB complex to dissociate from the phospho-IkB, Gallus gallus" xref: Reactome:REACT_25231 "Phosphorylation of IRF3 by IKK epsilon(IKBKE) complexed with activated TLR3., Gallus gallus" xref: Reactome:REACT_25285 "Phosphorylation of BRF1 by MK2, Homo sapiens" xref: Reactome:REACT_25288 "Activation of TAK1 complex bound to activated TLR4:TRAM:TRIF:pUb-TRAF6, Homo sapiens" xref: Reactome:REACT_25307 "Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1, Gallus gallus" xref: Reactome:REACT_25326 "Phosphorylation of Khsrp by p38 (mouse), Mus musculus" xref: Reactome:REACT_25335 "Phosphorylation of BRF1 by Protein Kinase B/Akt, Homo sapiens" xref: Reactome:REACT_25346 "Phosphorylation of IRF3 by TBK1 complexed with activated TLR3, Gallus gallus" xref: Reactome:REACT_25356 "Phosphorylation of Cry and Per Proteins, Mus musculus" xref: Reactome:REACT_25369 "Phosphorylation of STAT1 at Ser727, Homo sapiens" xref: Reactome:REACT_25375 "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3, Homo sapiens" xref: Reactome:REACT_25376 "Phosphorylation of MKK3/MKK6 by activated TAK1, Gallus gallus" xref: Reactome:REACT_25384 "Activation of JNK by DSCAM, Homo sapiens" xref: Reactome:REACT_25394 "Autophosphorylation of chicken IRAK4, Gallus gallus" xref: Reactome:REACT_27158 "IRAK4 binds to activated TLR5 or 15., Gallus gallus" xref: Reactome:REACT_27180 "IRAK4 autophosphorylation within the complex activated TLR:MyD88, Homo sapiens" xref: Reactome:REACT_27211 "Activation of recruited TAK1 within the complex p-IRAK2: pUb-TRAF6:TAB2/TAB3:TAB1:TAK1 upon TLR7 or 21 stimulation, Gallus gallus" xref: Reactome:REACT_27238 "IRAK2 phosphorylation bound to the activated TLR7 (or TLR21) complex, Gallus gallus" xref: Reactome:REACT_27261 "Autophosphorylation of IRAK4 bound to the activated TLR7 or 21complex., Gallus gallus" xref: Reactome:REACT_27299 "Activated IRAK4 bound to activated TLR : MyD88 complex phosphorylates IRAK2, Gallus gallus" xref: Reactome:REACT_28085 "AKT phosphorylates caspase-9, Taeniopygia guttata" xref: Reactome:REACT_28092 "Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex, Sus scrofa" xref: Reactome:REACT_28112 "MSK1 activates CREB, Gallus gallus" xref: Reactome:REACT_28138 "Activation of cytosolic AMPK by phosphorylation, Danio rerio" xref: Reactome:REACT_28220 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP, Sus scrofa" xref: Reactome:REACT_28367 "AKT phosphorylates caspase-9, Rattus norvegicus" xref: Reactome:REACT_28572 "Activation of recruited TAK1 within the complex viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:Ub-TAB2:Ub-TAB3: TAK1, Rattus norvegicus" xref: Reactome:REACT_28620 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP, Canis familiaris" xref: Reactome:REACT_28729 "Activation of TAK1-TAB2 complex, Gallus gallus" xref: Reactome:REACT_28738 "Active p38 MAPK phosphorylates MAPKAPK2 or 3, Drosophila melanogaster" xref: Reactome:REACT_28805 "ERK1/2 activates ELK1, Danio rerio" xref: Reactome:REACT_28809 "Active p38 MAPK phosphorylates MAPKAPK2 or 3, Sus scrofa" xref: Reactome:REACT_28822 "MEK2 phosphorylates ERK-2, Mus musculus" xref: Reactome:REACT_28827 "LIM kinase phosphorylation by ROCK, Canis familiaris" xref: Reactome:REACT_28936 "Activation of NF-kB complex, Bos taurus" xref: Reactome:REACT_29008 "Phosphorylation of FANCI by ATM/ATR, Oryza sativa" xref: Reactome:REACT_29035 "IKKbeta phosphorylates IkB causing NF-kB to dissociate, Mus musculus" xref: Reactome:REACT_29159 "RSK1/2/3 phosphorylates CREB at Serine 133, Canis familiaris" xref: Reactome:REACT_29403 "Phosphorylation of cPLA2 by MAPK p38 alpha, Gallus gallus" xref: Reactome:REACT_29503 "Phosphorylation of PKC theta, Caenorhabditis elegans" xref: Reactome:REACT_29509 "AKT phosphorylates p21Cip1 and p27Kip1, Mus musculus" xref: Reactome:REACT_29530 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9, Mus musculus" xref: Reactome:REACT_29733 "Phosphorylation of FANCI by ATM/ATR, Taeniopygia guttata" xref: Reactome:REACT_29781 "Phosphorylation of eIF2-alpha by PERK, Taeniopygia guttata" xref: Reactome:REACT_29936 "Phosphorylation of CRY and PER Proteins, Danio rerio" xref: Reactome:REACT_29959 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP, Canis familiaris" xref: Reactome:REACT_29999 "AKT interacts and phosphorylates Cot, Bos taurus" xref: Reactome:REACT_30143 "Inactivation of MEK1 by p34cdc2, Bos taurus" xref: Reactome:REACT_30149 "Activation of claspin, Rattus norvegicus" xref: Reactome:REACT_30175 "Phosphorylation of FANCI by ATM/ATR, Sus scrofa" xref: Reactome:REACT_30231 "AKT phosphorylates MDM2, Bos taurus" xref: Reactome:REACT_30415 "Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex, Canis familiaris" xref: Reactome:REACT_30432 "Autophosphorylation of IRE1 dimer, Drosophila melanogaster" xref: Reactome:REACT_30441 "LIM kinase phosphorylation by ROCK, Taeniopygia guttata" xref: Reactome:REACT_30475 "Activation of cytosolic AMPK by phosphorylation, Taeniopygia guttata" xref: Reactome:REACT_30512 "ERK1/2/5 activate RSK1/2/3, Rattus norvegicus" xref: Reactome:REACT_30534 "Phosphorylation of FANCD2 by ATR/ATM, Taeniopygia guttata" xref: Reactome:REACT_30570 "Activation of recruited TAK1 within the complex viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:Ub-TAB2:Ub-TAB3: TAK1, Xenopus tropicalis" xref: Reactome:REACT_30575 "MAP kinase activates MAPKAPK2, MAPKAPK3 and MSK1, Rattus norvegicus" xref: Reactome:REACT_30766 "MEK1 phosphorylates ERK-1, Canis familiaris" xref: Reactome:REACT_30848 "ERK1/2/5 activate RSK1/2/3, Sus scrofa" xref: Reactome:REACT_31008 "Phosphorylation of FANCI by ATM/ATR, Canis familiaris" xref: Reactome:REACT_31108 "MAPKAPK2 phosphorylates CREB at Serine 133, Xenopus tropicalis" xref: Reactome:REACT_31283 "Activation of cytosolic AMPK by phosphorylation, Canis familiaris" xref: Reactome:REACT_31328 "IKKbeta phosphorylates IkB causing NF-kB to dissociate, Bos taurus" xref: Reactome:REACT_31357 "Inactivation of MEK1 by p34cdc2, Gallus gallus" xref: Reactome:REACT_31513 "Activation of cytosolic AMPK by phosphorylation, Caenorhabditis elegans" xref: Reactome:REACT_31523 "Phosphorylation of PKC theta, Mus musculus" xref: Reactome:REACT_31662 "Phosphorylation of cPLA2 by MAPK p38 alpha, Canis familiaris" xref: Reactome:REACT_31760 "AKT phosphorylates caspase-9, Xenopus tropicalis" xref: Reactome:REACT_31783 "Phosphorylation of FANCI by ATM/ATR, Arabidopsis thaliana" xref: Reactome:REACT_31812 "AKT phosphorylates PRAS40, Canis familiaris" xref: Reactome:REACT_31857 "Phosphorylation of MARCKS by Protein kinase C, alpha type, Danio rerio" xref: Reactome:REACT_31893 "IKKbeta is activated, Sus scrofa" xref: Reactome:REACT_32225 "Phosphorylation of Bcl10, Taeniopygia guttata" xref: Reactome:REACT_32250 "AKT phosphorylates caspase-9, Canis familiaris" xref: Reactome:REACT_32384 "Activated TAK1 mediates phosphorylation of the IKK Complex, Bos taurus" xref: Reactome:REACT_32525 "AKT phosphorylates p21Cip1 and p27Kip1, Bos taurus" xref: Reactome:REACT_32572 "Activated TAK1 mediates phosphorylation of the IKK Complex, Rattus norvegicus" xref: Reactome:REACT_32621 "TORC2 (mTOR) phosphorylates AKT at S473, Bos taurus" xref: Reactome:REACT_32932 "Recruitment and activation of Chk1, Taeniopygia guttata" xref: Reactome:REACT_32954 "Phosphorylation of eIF2-alpha by PERK, Drosophila melanogaster" xref: Reactome:REACT_32974 "AKT phosphorylates IKKalpha, Taeniopygia guttata" xref: Reactome:REACT_33231 "Phosphorylation of cPLA2 by MAPK p38 alpha, Rattus norvegicus" xref: Reactome:REACT_33306 "p38MAPK phosphorylates MSK1, Rattus norvegicus" xref: Reactome:REACT_33413 "IKKbeta is activated, Danio rerio" xref: Reactome:REACT_33562 "Phosphorylation of L1 by p90rsk, Taeniopygia guttata" xref: Reactome:REACT_33594 "MAP kinase activates MAPKAPK2, MAPKAPK3 and MSK1, Taeniopygia guttata" xref: Reactome:REACT_33640 "Phosphorylation of CRY and PER Proteins, Canis familiaris" xref: Reactome:REACT_33709 "Phosphorylation of eIF2-alpha by PERK, Rattus norvegicus" xref: Reactome:REACT_33874 "Recruitment and activation of Chk1, Xenopus tropicalis" xref: Reactome:REACT_33935 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP, Canis familiaris" xref: Reactome:REACT_33943 "PDK1 phosphorylates AKT at T308, Taeniopygia guttata" xref: Reactome:REACT_34025 "IKKbeta is activated, Rattus norvegicus" xref: Reactome:REACT_34068 "AKT interacts and phosphorylates Cot, Canis familiaris" xref: Reactome:REACT_34104 "RSK1/2/3 phosphorylates CREB at Serine 133, Sus scrofa" xref: Reactome:REACT_34451 "Activation of cytosolic AMPK by phosphorylation, Sus scrofa" xref: Reactome:REACT_34455 "MEK1 phosphorylates ERK-1, Rattus norvegicus" xref: Reactome:REACT_34482 "MAPKAPK2 phosphorylates CREB at Serine 133, Danio rerio" xref: Reactome:REACT_34576 "Phosphorylation of CRY and PER Proteins, Bos taurus" xref: Reactome:REACT_34701 "AKT can phosphorylate RSK, Bos taurus" xref: Reactome:REACT_34785 "IKKbeta phosphorylates IkB causing NF-kB to dissociate, Canis familiaris" xref: Reactome:REACT_38602 "AKT phosphorylates IKKalpha, Mus musculus" xref: Reactome:REACT_388 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP, Rattus norvegicus" xref: Reactome:REACT_40374 "MSK1 activates ATF1, Gallus gallus" xref: Reactome:REACT_51458 "Active p38 MAPK phosphorylates MAPKAPK2 or 3, Gallus gallus" xref: Reactome:REACT_51558 "AKT can phosphorylate forkhead box transcription factors, Mus musculus" xref: Reactome:REACT_53247 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9, Gallus gallus" xref: Reactome:REACT_54933 "CERT + ATP => monophospho-CERT + ADP, Rattus norvegicus" xref: Reactome:REACT_60400 "AKT phosphorylates GSK3, Bos taurus" xref: Reactome:REACT_6197 "Activated DAkt1 phosphorylates TSC2 which inhibits the TSC1/2 complex, Drosophila melanogaster" xref: Reactome:REACT_6263 "DAkt1-mediated phosphorylation inactivates DFOXO, Drosophila melanogaster" xref: Reactome:REACT_62985 "Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex, Mus musculus" xref: Reactome:REACT_6719 "Phosphorylated MAPKs phosphorylate ATF-2, Homo sapiens" xref: Reactome:REACT_6728 "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR4 complex, Homo sapiens" xref: Reactome:REACT_6730 "Activation of recruited TAK1 within the complex viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:Ub-TAB2:Ub-TAB3: TAK1, Homo sapiens" xref: Reactome:REACT_6750 "Activation of claspin, Homo sapiens" xref: Reactome:REACT_6794 "Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal, Homo sapiens" xref: Reactome:REACT_6833 "First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal, Homo sapiens" xref: Reactome:REACT_6848 "Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex, Homo sapiens" xref: Reactome:REACT_6869 "Recruitment and activation of Chk1, Homo sapiens" xref: Reactome:REACT_69155 "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding, Canis familiaris" xref: Reactome:REACT_6935 "Activated TAK1 mediates phosphorylation of the IKK Complex, Homo sapiens" xref: Reactome:REACT_75759 "Atr Phosphorylates Histone H2A.X at Unsynapsed Regions, Mus musculus" xref: Reactome:REACT_75904 "ATR Phosphorylates Histone H2A.X at Unsynapsed Regions, Homo sapiens" xref: Reactome:REACT_75910 "SMG1 Phosphorylates UPF1 (Enhanced by Exon Junction Complex), Homo sapiens" xref: Reactome:REACT_77037 "LIM kinase phosphorylation by ROCK, Gallus gallus" xref: Reactome:REACT_77098 "Phosphorylation of cPLA2 by MAPK p38 alpha, Xenopus tropicalis" xref: Reactome:REACT_77159 "ALOX5 is phosphorylated by MAPKAP2, Danio rerio" xref: Reactome:REACT_77220 "ERK1/2 activates ELK1, Rattus norvegicus" xref: Reactome:REACT_77282 "AKT can phosphorylate NUR77, Xenopus tropicalis" xref: Reactome:REACT_77423 "AKT phosphorylates TSC2, inhibiting it, Drosophila melanogaster" xref: Reactome:REACT_77580 "Phosphorylation of MARCKS by Protein kinase C, alpha type, Sus scrofa" xref: Reactome:REACT_77617 "AKT phosphorylates MDM2, Taeniopygia guttata" xref: Reactome:REACT_77748 "Myosin regulatory light chain phosphorylation by ROCK, Bos taurus" xref: Reactome:REACT_77752 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP, Danio rerio" xref: Reactome:REACT_77909 "PKA phosphorylates CREB, Taeniopygia guttata" xref: Reactome:REACT_77980 "AKT phosphorylates MDM2, Xenopus tropicalis" xref: Reactome:REACT_78070 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP, Drosophila melanogaster" xref: Reactome:REACT_78202 "AKT phosphorylates BAD, Mus musculus" xref: Reactome:REACT_78246 "Phosphorylation of CRMPs by GSK3beta, Canis familiaris" xref: Reactome:REACT_78283 "MSK1 activates ATF1, Bos taurus" xref: Reactome:REACT_78357 "Inactivation of MEK1 by p34cdc2, Rattus norvegicus" xref: Reactome:REACT_78364 "Phosphorylation of LIMK-1 by PAK, Taeniopygia guttata" xref: Reactome:REACT_78401 "MEK1 phosphorylates ERK-1, Danio rerio" xref: Reactome:REACT_78606 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9, Canis familiaris" xref: Reactome:REACT_78657 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP, Bos taurus" xref: Reactome:REACT_78797 "Phosphorylation of PKC theta, Danio rerio" xref: Reactome:REACT_78839 "MEK2 phosphorylates ERK-2, Bos taurus" xref: Reactome:REACT_78999 "TORC2 (mTOR) phosphorylates AKT at S473, Mus musculus" xref: Reactome:REACT_79009 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9, Xenopus tropicalis" xref: Reactome:REACT_79017 "IRAK is activated, Bos taurus" xref: Reactome:REACT_79041 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9, Taeniopygia guttata" xref: Reactome:REACT_79081 "Autophosphorylation of IRE1 dimer, Caenorhabditis elegans" xref: Reactome:REACT_79082 "Phosphorylation of CRMPs by Cdk5, Danio rerio" xref: Reactome:REACT_79223 "Activation of IKK complex, Canis familiaris" xref: Reactome:REACT_79270 "MAP kinase activates MAPKAPK2, MAPKAPK3 and MSK1, Mus musculus" xref: Reactome:REACT_79290 "MSK1 activates ATF1, Canis familiaris" xref: Reactome:REACT_79294 "Autophosphorylation of PAK, Canis familiaris" xref: Reactome:REACT_79368 "Phosphorylated MAPKs phosphorylate ATF-2, Xenopus tropicalis" xref: Reactome:REACT_79396 "AKT phosphorylates CREB, Xenopus tropicalis" xref: Reactome:REACT_79454 "AKT phosphorylates p21Cip1 and p27Kip1, Xenopus tropicalis" xref: Reactome:REACT_79465 "Phosphorylation of cofilin by LIMK-1, Dictyostelium discoideum" xref: Reactome:REACT_79487 "MEK1 phosphorylates ERK-1, Caenorhabditis elegans" xref: Reactome:REACT_79578 "AKT can phosphorylate NUR77, Taeniopygia guttata" xref: Reactome:REACT_79606 "Phosphorylation of FANCD2 by ATR/ATM, Bos taurus" xref: Reactome:REACT_79732 "AKT phosphorylates p21Cip1 and p27Kip1, Canis familiaris" xref: Reactome:REACT_79796 "p38MAPK phosphorylates MSK1, Bos taurus" xref: Reactome:REACT_79838 "Activation of TAK1-TAB2 complex, Rattus norvegicus" xref: Reactome:REACT_79875 "LIM kinase phosphorylation by ROCK, Xenopus tropicalis" xref: Reactome:REACT_79905 "TORC2 (mTOR) phosphorylates AKT at S473, Drosophila melanogaster" xref: Reactome:REACT_80036 "Phosphorylation of FANCI by ATM/ATR, Gallus gallus" xref: Reactome:REACT_80060 "PKA phosphorylates CREB, Xenopus tropicalis" xref: Reactome:REACT_80149 "Phosphorylation of FANCD2 by ATR/ATM, Caenorhabditis elegans" xref: Reactome:REACT_80188 "p38MAPK phosphorylates MSK1, Sus scrofa" xref: Reactome:REACT_80214 "AKT phosphorylates TSC2, inhibiting it, Canis familiaris" xref: Reactome:REACT_80294 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9, Xenopus tropicalis" xref: Reactome:REACT_80369 "Activation of NF-kB complex, Rattus norvegicus" xref: Reactome:REACT_80488 "AKT phosphorylates p21Cip1 and p27Kip1, Taeniopygia guttata" xref: Reactome:REACT_80566 "RSK1/2/3 phosphorylates CREB at Serine 133, Rattus norvegicus" xref: Reactome:REACT_80571 "Activation of claspin, Mus musculus" xref: Reactome:REACT_80638 "MSK1 activates ATF1, Rattus norvegicus" xref: Reactome:REACT_80833 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9, Bos taurus" xref: Reactome:REACT_80847 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP, Bos taurus" xref: Reactome:REACT_80870 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9, Bos taurus" xref: Reactome:REACT_80884 "Inactivation of MEK1 by p34cdc2, Xenopus tropicalis" xref: Reactome:REACT_80885 "Phosphorylation of CARMA1, Danio rerio" xref: Reactome:REACT_80896 "Recruitment and activation of Chk1, Sus scrofa" xref: Reactome:REACT_80942 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9, Canis familiaris" xref: Reactome:REACT_80981 "Autophosphorylation of PAK, Danio rerio" xref: Reactome:REACT_80994 "ALOX5 is phosphorylated by MAPKAP2, Xenopus tropicalis" xref: Reactome:REACT_81006 "Phosphorylated MAPKs phosphorylate ATF-2, Taeniopygia guttata" xref: Reactome:REACT_81015 "Autophosphorylation of PAK, Mus musculus" xref: Reactome:REACT_81028 "Activation of recruited TAK1 within the complex viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:Ub-TAB2:Ub-TAB3: TAK1, Mus musculus" xref: Reactome:REACT_81170 "Phosphorylation of CARMA1, Bos taurus" xref: Reactome:REACT_81226 "AKT phosphorylates BAD, Bos taurus" xref: Reactome:REACT_81279 "Activation of TAK1-TAB2 complex, Mus musculus" xref: Reactome:REACT_81426 "Autophosphorylation of IRE1 dimer, Schizosaccharomyces pombe" xref: Reactome:REACT_81514 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP, Taeniopygia guttata" xref: Reactome:REACT_81917 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9, Gallus gallus" xref: Reactome:REACT_81999 "CERT + ATP => monophospho-CERT + ADP, Mus musculus" xref: Reactome:REACT_82094 "AKT can phosphorylate RSK, Canis familiaris" xref: Reactome:REACT_82308 "AKT phosphorylates TSC2, inhibiting it, Taeniopygia guttata" xref: Reactome:REACT_82341 "MEK2 phosphorylates ERK-2, Sus scrofa" xref: Reactome:REACT_82426 "Phosphorylation of CRMPs by GSK3beta, Xenopus tropicalis" xref: Reactome:REACT_82465 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9, Sus scrofa" xref: Reactome:REACT_82486 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9, Danio rerio" xref: Reactome:REACT_82487 "Transphosphorylation of pLIMK1, Gallus gallus" xref: Reactome:REACT_82570 "Autophosphorylation of IRE1 dimer, Gallus gallus" xref: Reactome:REACT_82577 "Phosphorylation of FANCD2 by ATR/ATM, Danio rerio" xref: Reactome:REACT_82668 "AKT phosphorylates CREB, Taeniopygia guttata" xref: Reactome:REACT_82929 "Phosphorylated MAPKs phosphorylate ATF-2, Canis familiaris" xref: Reactome:REACT_82960 "Activation of IKK complex, Rattus norvegicus" xref: Reactome:REACT_82976 "ALOX5 is phosphorylated by MAPKAP2, Canis familiaris" xref: Reactome:REACT_82982 "PDK1 phosphorylates AKT at T308, Bos taurus" xref: Reactome:REACT_83066 "ERK1/2/5 activate RSK1/2/3, Bos taurus" xref: Reactome:REACT_83075 "Phosphorylation of CARMA1, Taeniopygia guttata" xref: Reactome:REACT_83134 "IKKbeta phosphorylates IkB causing NF-kB to dissociate, Rattus norvegicus" xref: Reactome:REACT_83280 "AKT can phosphorylate NUR77, Bos taurus" xref: Reactome:REACT_83306 "RSK1/2/3 phosphorylates CREB at Serine 133, Gallus gallus" xref: Reactome:REACT_83327 "Autophosphorylation of PAK, Sus scrofa" xref: Reactome:REACT_83341 "Phosphorylation of cPLA2 by MAPK p38 alpha, Mus musculus" xref: Reactome:REACT_83437 "AKT phosphorylates BAD, Rattus norvegicus" xref: Reactome:REACT_83704 "Activation of recruited TAK1 within the complex viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:Ub-TAB2:Ub-TAB3: TAK1, Sus scrofa" xref: Reactome:REACT_83820 "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding, Rattus norvegicus" xref: Reactome:REACT_83896 "Phosphorylation of LIMK-1 by PAK, Canis familiaris" xref: Reactome:REACT_83924 "Phosphorylation of CRMPs by Cdk5, Canis familiaris" xref: Reactome:REACT_83927 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP, Sus scrofa" xref: Reactome:REACT_84390 "Phosphorylation of LIMK-1 by PAK, Rattus norvegicus" xref: Reactome:REACT_84454 "Phosphorylation of LIMK-1 by PAK, Gallus gallus" xref: Reactome:REACT_84496 "Phosphorylation of Cdc25C at Ser 216 by Chk1, Sus scrofa" xref: Reactome:REACT_84727 "Phosphorylation of Cdc25C at Ser 216 by Chk1, Xenopus tropicalis" xref: Reactome:REACT_84803 "Phosphorylation of CRMPs by GSK3beta, Rattus norvegicus" xref: Reactome:REACT_84957 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9, Xenopus tropicalis" xref: Reactome:REACT_84970 "AKT phosphorylates IKKalpha, Drosophila melanogaster" xref: Reactome:REACT_85026 "Inactivation of MEK1 by p34cdc2, Mus musculus" xref: Reactome:REACT_85069 "Phosphorylation of CRMPs by Cdk5, Bos taurus" xref: Reactome:REACT_85146 "MAP kinase activates MAPKAPK2, MAPKAPK3 and MSK1, Drosophila melanogaster" xref: Reactome:REACT_85195 "IRAK is activated, Xenopus tropicalis" xref: Reactome:REACT_85259 "ALOX5 is phosphorylated by MAPKAP2, Sus scrofa" xref: Reactome:REACT_85327 "AKT phosphorylates CREB, Mus musculus" xref: Reactome:REACT_85429 "MAPKAPK2 phosphorylates CREB at Serine 133, Gallus gallus" xref: Reactome:REACT_85676 "Activation of NF-kB complex, Mus musculus" xref: Reactome:REACT_85714 "IKKbeta phosphorylates IkB causing NF-kB to dissociate, Sus scrofa" xref: Reactome:REACT_85726 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP, Xenopus tropicalis" xref: Reactome:REACT_85756 "ERK1/2 phosphorylates MSK1, Bos taurus" xref: Reactome:REACT_85863 "Phosphorylated MAPKs phosphorylate ATF-2, Danio rerio" xref: Reactome:REACT_86006 "ERK5 activates the transcription factor MEF2, Oryza sativa" xref: Reactome:REACT_86021 "Phosphorylation of FANCD2 by ATR/ATM, Drosophila melanogaster" xref: Reactome:REACT_86110 "Activation of TAK1-TAB2 complex, Canis familiaris" xref: Reactome:REACT_86121 "Phosphorylation of Bcl10, Danio rerio" xref: Reactome:REACT_86147 "AKT phosphorylates CREB, Rattus norvegicus" xref: Reactome:REACT_86151 "Activation of TAK1-TAB2 complex, Taeniopygia guttata" xref: Reactome:REACT_86231 "TORC2 (mTOR) phosphorylates AKT at S473, Xenopus tropicalis" xref: Reactome:REACT_86283 "PDK1 phosphorylates AKT at T308, Drosophila melanogaster" xref: Reactome:REACT_86598 "PKA phosphorylates CREB, Sus scrofa" xref: Reactome:REACT_86646 "Autophosphorylation of IRE1 dimer, Sus scrofa" xref: Reactome:REACT_86677 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP, Danio rerio" xref: Reactome:REACT_86724 "AKT can phosphorylate forkhead box transcription factors, Bos taurus" xref: Reactome:REACT_86739 "Recruitment and activation of Chk1, Rattus norvegicus" xref: Reactome:REACT_86841 "AKT phosphorylates PRAS40, Mus musculus" xref: Reactome:REACT_86847 "Phosphorylation of FANCI by ATM/ATR, Rattus norvegicus" xref: Reactome:REACT_86929 "LIM kinase phosphorylation by ROCK, Rattus norvegicus" xref: Reactome:REACT_86978 "Activated TAK1 mediates phosphorylation of the IKK Complex, Canis familiaris" xref: Reactome:REACT_86988 "Phosphorylation of FANCD2 by ATR/ATM, Arabidopsis thaliana" xref: Reactome:REACT_87026 "Phosphorylation of CRMPs by Cdk5, Mus musculus" xref: Reactome:REACT_87041 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9, Taeniopygia guttata" xref: Reactome:REACT_87092 "Phosphorylation of CRY and PER Proteins, Rattus norvegicus" xref: Reactome:REACT_87111 "ERK1/2 activates ELK1, Bos taurus" xref: Reactome:REACT_87190 "Activation of IKK complex, Bos taurus" xref: Reactome:REACT_87348 "Phosphorylation of PKC theta, Gallus gallus" xref: Reactome:REACT_87421 "Phosphorylation of cofilin by LIMK-1, Drosophila melanogaster" xref: Reactome:REACT_87451 "AKT interacts and phosphorylates Cot, Rattus norvegicus" xref: Reactome:REACT_87456 "IRAK is activated, Mus musculus" xref: Reactome:REACT_87461 "Autophosphorylation of PAK, Xenopus tropicalis" xref: Reactome:REACT_87481 "Activation of cytosolic AMPK by phosphorylation, Mus musculus" xref: Reactome:REACT_87543 "AKT phosphorylates CREB, Canis familiaris" xref: Reactome:REACT_87575 "CERT + ATP => monophospho-CERT + ADP, Xenopus tropicalis" xref: Reactome:REACT_87625 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9, Sus scrofa" xref: Reactome:REACT_87637 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP, Gallus gallus" xref: Reactome:REACT_87667 "AKT interacts and phosphorylates Cot, Xenopus tropicalis" xref: Reactome:REACT_87833 "PDK1 phosphorylates AKT at T308, Rattus norvegicus" xref: Reactome:REACT_87846 "ERK1/2/5 activate RSK1/2/3, Saccharomyces cerevisiae" xref: Reactome:REACT_87861 "Phosphorylation of PKC theta, Rattus norvegicus" xref: Reactome:REACT_87870 "Phosphorylated MAPKs phosphorylate ATF-2, Schizosaccharomyces pombe" xref: Reactome:REACT_87896 "ALOX5 is phosphorylated by MAPKAP2, Bos taurus" xref: Reactome:REACT_88189 "MSK1 activates ATF1, Mus musculus" xref: Reactome:REACT_88241 "AKT can phosphorylate forkhead box transcription factors, Rattus norvegicus" xref: Reactome:REACT_88277 "Activation of cytosolic AMPK by phosphorylation, Xenopus tropicalis" xref: Reactome:REACT_88488 "Phosphorylation of L1 by p90rsk, Bos taurus" xref: Reactome:REACT_88490 "Myosin regulatory light chain phosphorylation by ROCK, Caenorhabditis elegans" xref: Reactome:REACT_88529 "Activation of claspin, Gallus gallus" xref: Reactome:REACT_88559 "Phosphorylation of FANCD2 by ATR/ATM, Xenopus tropicalis" xref: Reactome:REACT_88591 "Activated TAK1 mediates phosphorylation of the IKK Complex, Danio rerio" xref: Reactome:REACT_88650 "MSK1 activates ATF1, Taeniopygia guttata" xref: Reactome:REACT_88937 "IKKbeta is activated, Mus musculus" xref: Reactome:REACT_88973 "Phosphorylation of L1 by p90rsk, Mus musculus" xref: Reactome:REACT_89047 "AKT phosphorylates MDM2, Rattus norvegicus" xref: Reactome:REACT_89054 "RSK1/2/3 phosphorylates CREB at Serine 133, Xenopus tropicalis" xref: Reactome:REACT_89078 "MSK1 activates CREB, Danio rerio" xref: Reactome:REACT_89089 "Phosphorylation of L1 by p90rsk, Caenorhabditis elegans" xref: Reactome:REACT_89170 "Phosphorylation of FANCI by ATM/ATR, Bos taurus" xref: Reactome:REACT_89266 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP, Danio rerio" xref: Reactome:REACT_89355 "Activation of claspin, Danio rerio" xref: Reactome:REACT_89389 "Transphosphorylation of pLIMK1, Xenopus tropicalis" xref: Reactome:REACT_89425 "AKT phosphorylates BAD, Canis familiaris" xref: Reactome:REACT_89433 "Phosphorylated MAPKs phosphorylate ATF-2, Bos taurus" xref: Reactome:REACT_89557 "RSK1/2/3 phosphorylates CREB at Serine 133, Taeniopygia guttata" xref: Reactome:REACT_89611 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9, Mus musculus" xref: Reactome:REACT_89699 "IRAK is activated, Danio rerio" xref: Reactome:REACT_89806 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP, Xenopus tropicalis" xref: Reactome:REACT_89830 "Activation of TAK1-TAB2 complex, Danio rerio" xref: Reactome:REACT_89908 "ERK5 activates the transcription factor MEF2, Bos taurus" xref: Reactome:REACT_89984 "Phosphorylation of PKC theta, Sus scrofa" xref: Reactome:REACT_90010 "Phosphorylation of eIF2-alpha by PERK, Canis familiaris" xref: Reactome:REACT_90071 "Phosphorylation of eIF2-alpha by PERK, Gallus gallus" xref: Reactome:REACT_90165 "Phosphorylation of PKC theta, Canis familiaris" xref: Reactome:REACT_90173 "TORC2 (mTOR) phosphorylates AKT at S473, Rattus norvegicus" xref: Reactome:REACT_90268 "p38MAPK phosphorylates MSK1, Taeniopygia guttata" xref: Reactome:REACT_90319 "PDK1 phosphorylates AKT at T308, Mus musculus" xref: Reactome:REACT_90333 "AKT phosphorylates GSK3, Canis familiaris" xref: Reactome:REACT_90350 "Activation of NF-kB complex, Canis familiaris" xref: Reactome:REACT_90442 "MAP kinase activates MAPKAPK2, MAPKAPK3 and MSK1, Canis familiaris" xref: Reactome:REACT_90464 "Phosphorylation of LIMK-1 by PAK, Xenopus tropicalis" xref: Reactome:REACT_90486 "AKT phosphorylates TSC2, inhibiting it, Rattus norvegicus" xref: Reactome:REACT_90546 "Active p38 MAPK phosphorylates MAPKAPK2 or 3, Danio rerio" xref: Reactome:REACT_90590 "MAPKAPK2 phosphorylates CREB at Serine 133, Mus musculus" xref: Reactome:REACT_90752 "TORC2 (mTOR) phosphorylates AKT at S473, Caenorhabditis elegans" xref: Reactome:REACT_91042 "Transphosphorylation of pLIMK1, Rattus norvegicus" xref: Reactome:REACT_91083 "Phosphorylation of PKC theta, Bos taurus" xref: Reactome:REACT_91184 "Recruitment and activation of Chk1, Danio rerio" xref: Reactome:REACT_91247 "Phosphorylation of cofilin by LIMK-1, Xenopus tropicalis" xref: Reactome:REACT_91489 "Autophosphorylation of IRE1 dimer, Taeniopygia guttata" xref: Reactome:REACT_91679 "Activation of TAK1-TAB2 complex, Bos taurus" xref: Reactome:REACT_91687 "Phosphorylation of FANCI by ATM/ATR, Xenopus tropicalis" xref: Reactome:REACT_91695 "AKT phosphorylates GSK3, Taeniopygia guttata" xref: Reactome:REACT_91715 "AKT phosphorylates GSK3, Mus musculus" xref: Reactome:REACT_91808 "Autophosphorylation of IRE1 dimer, Mus musculus" xref: Reactome:REACT_91830 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9, Sus scrofa" xref: Reactome:REACT_92125 "Activation of IKK complex, Mus musculus" xref: Reactome:REACT_92263 "TORC2 (mTOR) phosphorylates AKT at S473, Taeniopygia guttata" xref: Reactome:REACT_92406 "Phosphorylation of CRMPs by Cdk5, Sus scrofa" xref: Reactome:REACT_92416 "ERK1/2 phosphorylates MSK1, Caenorhabditis elegans" xref: Reactome:REACT_92486 "AKT phosphorylates CREB, Bos taurus" xref: Reactome:REACT_92872 "PKA phosphorylates CREB, Bos taurus" xref: Reactome:REACT_92890 "ERK1/2/5 activate RSK1/2/3, Taeniopygia guttata" xref: Reactome:REACT_92893 "ERK1/2 phosphorylates MSK1, Sus scrofa" xref: Reactome:REACT_93044 "MSK1 activates CREB, Mus musculus" xref: Reactome:REACT_93073 "Autophosphorylation of IRE1 dimer, Rattus norvegicus" xref: Reactome:REACT_93082 "ERK5 activates the transcription factor MEF2, Danio rerio" xref: Reactome:REACT_93212 "RSK1/2/3 phosphorylates CREB at Serine 133, Bos taurus" xref: Reactome:REACT_93229 "Activation of recruited TAK1 within the complex viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:Ub-TAB2:Ub-TAB3: TAK1, Canis familiaris" xref: Reactome:REACT_93303 "ERK1/2 phosphorylates MSK1, Taeniopygia guttata" xref: Reactome:REACT_93390 "MAP kinase activates MAPKAPK2, MAPKAPK3 and MSK1, Gallus gallus" xref: Reactome:REACT_93505 "Phosphorylation of L1 by p90rsk, Drosophila melanogaster" xref: Reactome:REACT_93588 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP, Taeniopygia guttata" xref: Reactome:REACT_93911 "ERK5 activates the transcription factor MEF2, Canis familiaris" xref: Reactome:REACT_93914 "LIM kinase phosphorylation by ROCK, Mus musculus" xref: Reactome:REACT_93919 "Activation of recruited TAK1 within the complex viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:Ub-TAB2:Ub-TAB3: TAK1, Bos taurus" xref: Reactome:REACT_93998 "AKT can phosphorylate RSK, Caenorhabditis elegans" xref: Reactome:REACT_94044 "Phosphorylation of CARMA1, Canis familiaris" xref: Reactome:REACT_94069 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9, Gallus gallus" xref: Reactome:REACT_94072 "Phosphorylation of L1 by p90rsk, Rattus norvegicus" xref: Reactome:REACT_94250 "AKT phosphorylates PRAS40, Bos taurus" xref: Reactome:REACT_94366 "Phosphorylation of CRMPs by GSK3beta, Danio rerio" xref: Reactome:REACT_94474 "Activation of recruited TAK1 within the complex viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:Ub-TAB2:Ub-TAB3: TAK1, Danio rerio" xref: Reactome:REACT_94526 "AKT phosphorylates TSC2, inhibiting it, Bos taurus" xref: Reactome:REACT_94639 "Autophosphorylation of IRE1 dimer, Bos taurus" xref: Reactome:REACT_94736 "p38MAPK phosphorylates MSK1, Gallus gallus" xref: Reactome:REACT_95091 "AKT phosphorylates MDM2, Mus musculus" xref: Reactome:REACT_95131 "CERT + ATP => monophospho-CERT + ADP, Bos taurus" xref: Reactome:REACT_95329 "Activation of claspin, Taeniopygia guttata" xref: Reactome:REACT_95335 "Phosphorylation of Bcl10, Rattus norvegicus" xref: Reactome:REACT_95356 "MEK2 phosphorylates ERK-2, Taeniopygia guttata" xref: Reactome:REACT_95369 "AKT phosphorylates PRAS40, Xenopus tropicalis" xref: Reactome:REACT_95525 "Transphosphorylation of pLIMK1, Canis familiaris" xref: Reactome:REACT_95566 "Phosphorylation of eIF2-alpha by PERK, Mus musculus" xref: Reactome:REACT_95602 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP, Mus musculus" xref: Reactome:REACT_95622 "Activation of recruited TAK1 within the complex viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:Ub-TAB2:Ub-TAB3: TAK1, Taeniopygia guttata" xref: Reactome:REACT_95641 "PDK1 phosphorylates AKT at T308, Xenopus tropicalis" xref: Reactome:REACT_95651 "Transphosphorylation of pLIMK1, Danio rerio" xref: Reactome:REACT_95762 "Phosphorylation of FANCD2 by ATR/ATM, Dictyostelium discoideum" xref: Reactome:REACT_95795 "ERK1/2/5 activate RSK1/2/3, Drosophila melanogaster" xref: Reactome:REACT_95850 "Phosphorylation of L1 by p90rsk, Xenopus tropicalis" xref: Reactome:REACT_95931 "MAP kinase activates MAPKAPK2, MAPKAPK3 and MSK1, Bos taurus" xref: Reactome:REACT_95935 "AKT phosphorylates TSC2, inhibiting it, Xenopus tropicalis" xref: Reactome:REACT_95951 "AKT can phosphorylate forkhead box transcription factors, Taeniopygia guttata" xref: Reactome:REACT_95952 "ERK5 activates the transcription factor MEF2, Mus musculus" xref: Reactome:REACT_96092 "p38MAPK phosphorylates MSK1, Canis familiaris" xref: Reactome:REACT_96204 "ERK1/2 phosphorylates MSK1, Rattus norvegicus" xref: Reactome:REACT_96268 "Phosphorylation of FANCD2 by ATR/ATM, Mus musculus" xref: Reactome:REACT_96340 "MEK2 phosphorylates ERK-2, Rattus norvegicus" xref: Reactome:REACT_96427 "AKT can phosphorylate RSK, Drosophila melanogaster" xref: Reactome:REACT_96505 "ERK1/2 phosphorylates MSK1, Gallus gallus" xref: Reactome:REACT_96534 "Phosphorylation of CRY and PER Proteins, Taeniopygia guttata" xref: Reactome:REACT_96546 "CERT + ATP => monophospho-CERT + ADP, Danio rerio" xref: Reactome:REACT_96553 "IKKbeta phosphorylates IkB causing NF-kB to dissociate, Xenopus tropicalis" xref: Reactome:REACT_96657 "MSK1 activates CREB, Canis familiaris" xref: Reactome:REACT_96659 "Phosphorylation of CARMA1, Mus musculus" xref: Reactome:REACT_96804 "Recruitment and activation of Chk1, Mus musculus" xref: Reactome:REACT_96823 "AKT can phosphorylate NUR77, Rattus norvegicus" xref: Reactome:REACT_96825 "IRAK is activated, Sus scrofa" xref: Reactome:REACT_96850 "MAPKAPK2 phosphorylates CREB at Serine 133, Rattus norvegicus" xref: Reactome:REACT_97199 "Phosphorylation of CRMPs by Cdk5, Rattus norvegicus" xref: Reactome:REACT_97207 "AKT phosphorylates GSK3, Xenopus tropicalis" xref: Reactome:REACT_97335 "ERK5 activates the transcription factor MEF2, Arabidopsis thaliana" xref: Reactome:REACT_97343 "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding, Bos taurus" xref: Reactome:REACT_97347 "ERK1/2/5 activate RSK1/2/3, Caenorhabditis elegans" xref: Reactome:REACT_97394 "CERT + ATP => monophospho-CERT + ADP, Canis familiaris" xref: Reactome:REACT_97476 "Phosphorylation of LIMK-1 by PAK, Mus musculus" xref: Reactome:REACT_97497 "IKKbeta is activated, Xenopus tropicalis" xref: Reactome:REACT_97544 "MSK1 activates CREB, Taeniopygia guttata" xref: Reactome:REACT_97593 "Phosphorylation of Cdc25C at Ser 216 by Chk1, Drosophila melanogaster" xref: Reactome:REACT_97635 "Phosphorylation of cPLA2 by MAPK p38 alpha, Bos taurus" xref: Reactome:REACT_97792 "Phosphorylation of Bcl10, Mus musculus" xref: Reactome:REACT_97842 "IKKbeta is activated, Gallus gallus" xref: Reactome:REACT_97853 "AKT can phosphorylate RSK, Mus musculus" xref: Reactome:REACT_98007 "ERK1/2 phosphorylates MSK1, Danio rerio" xref: Reactome:REACT_98032 "Inactivation of MEK1 by p34cdc2, Canis familiaris" xref: Reactome:REACT_98044 "Phosphorylation of FANCD2 by ATR/ATM, Canis familiaris" xref: Reactome:REACT_98057 "ALOX5 is phosphorylated by MAPKAP2, Rattus norvegicus" xref: Reactome:REACT_98110 "ERK1/2 phosphorylates MSK1, Drosophila melanogaster" xref: Reactome:REACT_98114 "Autophosphorylation of PAK, Bos taurus" xref: Reactome:REACT_98193 "MSK1 activates ATF1, Danio rerio" xref: Reactome:REACT_98197 "RSK1/2/3 phosphorylates CREB at Serine 133, Danio rerio" xref: Reactome:REACT_98215 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9, Rattus norvegicus" xref: Reactome:REACT_98244 "Activated TAK1 mediates phosphorylation of the IKK Complex, Mus musculus" xref: Reactome:REACT_98255 "ERK1/2/5 activate RSK1/2/3, Mus musculus" xref: Reactome:REACT_98315 "Activation of cytosolic AMPK by phosphorylation, Drosophila melanogaster" xref: Reactome:REACT_98317 "Phosphorylation of Cdc25C at Ser 216 by Chk1, Bos taurus" xref: Reactome:REACT_98318 "AKT interacts and phosphorylates Cot, Mus musculus" xref: Reactome:REACT_98411 "Activation of IKK complex, Sus scrofa" xref: Reactome:REACT_98629 "MEK2 phosphorylates ERK-2, Canis familiaris" xref: Reactome:REACT_98897 "RSK1/2/3 phosphorylates CREB at Serine 133, Mus musculus" xref: Reactome:REACT_98965 "Phosphorylation of L1 by p90rsk, Sus scrofa" xref: Reactome:REACT_98966 "MSK1 activates CREB, Bos taurus" xref: Reactome:REACT_99035 "Activation of NF-kB complex, Sus scrofa" xref: Reactome:REACT_99196 "Phosphorylation of CRMPs by GSK3beta, Mus musculus" xref: Reactome:REACT_99214 "Phosphorylation of PKC theta, Drosophila melanogaster" xref: Reactome:REACT_99234 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9, Rattus norvegicus" xref: Reactome:REACT_99270 "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding, Sus scrofa" xref: Reactome:REACT_99324 "Phosphorylation of eIF2-alpha by PERK, Danio rerio" xref: Reactome:REACT_99345 "AKT phosphorylates MDM2, Canis familiaris" xref: Reactome:REACT_99388 "Phosphorylation of FANCD2 by ATR/ATM, Rattus norvegicus" xref: Reactome:REACT_99466 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP, Bos taurus" xref: Reactome:REACT_99563 "MAP kinase activates MAPKAPK2, MAPKAPK3 and MSK1, Danio rerio" xref: Reactome:REACT_99566 "IKKbeta is activated, Canis familiaris" xref: Reactome:REACT_99606 "Phosphorylation of eIF2-alpha by PERK, Sus scrofa" xref: Reactome:REACT_99613 "PKA phosphorylates CREB, Gallus gallus" xref: Reactome:REACT_99631 "IRAK is activated, Gallus gallus" xref: Reactome:REACT_99778 "MAPKAPK2 phosphorylates CREB at Serine 133, Canis familiaris" xref: Reactome:REACT_99808 "MAP kinase activates MAPKAPK2, MAPKAPK3 and MSK1, Xenopus tropicalis" xref: Reactome:REACT_99812 "ERK1/2 activates ELK1, Sus scrofa" xref: Reactome:REACT_99873 "Activation of recruited TAK1 within the complex viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:Ub-TAB2:Ub-TAB3: TAK1, Gallus gallus" xref: Reactome:REACT_99884 "Phosphorylation of Bcl10, Canis familiaris" xref: Reactome:REACT_99943 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9, Danio rerio" is_a: GO:0004672 ! protein kinase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004690 name: cyclic nucleotide-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of a cyclic nucleotide." [GOC:mah] xref: EC:2.7.11.- is_a: GO:0004674 ! protein serine/threonine kinase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004691 name: cAMP-dependent protein kinase activity namespace: molecular_function alt_id: GO:0008602 def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cAMP." [EC:2.7.11.11] synonym: "3',5' cAMP-dependent protein kinase activity" EXACT [] synonym: "3',5'-cAMP-dependent protein kinase activity" EXACT [] synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase activity" EXACT [] synonym: "AMPK" RELATED [EC:2.7.11.11] synonym: "ATP:protein phosphotransferase (cAMP-dependent) activity" EXACT [EC:2.7.11.11] synonym: "cAMP-dependent protein kinase, intrinsic catalyst activity" EXACT [] synonym: "cyclic AMP-dependent protein kinase activity" EXACT [] synonym: "PKA" RELATED [EC:2.7.11.11] synonym: "PKA C" RELATED [EC:2.7.11.11] synonym: "protein kinase A activity" BROAD [EC:2.7.11.11] synonym: "STK22" RELATED [EC:2.7.11.11] xref: EC:2.7.11.11 xref: MetaCyc:2.7.11.11-RXN xref: Reactome:REACT_102063 "PKA phosphorylates PDE4B, Mus musculus" xref: Reactome:REACT_102147 "PKA phosphorylates DARPP-32 on Thr34, Canis familiaris" xref: Reactome:REACT_105123 "Phosphorylation of PF2K-Pase by PKA catalytic subunit, Taeniopygia guttata" xref: Reactome:REACT_106524 "PKA phosphorylates DARPP-32 on Thr34, Mus musculus" xref: Reactome:REACT_106641 "PKA phosphorylates DARPP-32 on Thr34, Rattus norvegicus" xref: Reactome:REACT_107015 "Phosphorylation of ChREBP at Thr(666) by PKA, Gallus gallus" xref: Reactome:REACT_108468 "Phosphorylation of PF2K-Pase by PKA catalytic subunit, Schizosaccharomyces pombe" xref: Reactome:REACT_108471 "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA), Sus scrofa" xref: Reactome:REACT_109379 "Phosphorylation of PF2K-Pase by PKA catalytic subunit, Canis familiaris" xref: Reactome:REACT_110878 "Phosphorylation of ChREBP at Thr(666) by PKA, Sus scrofa" xref: Reactome:REACT_112372 "Phosphorylation of ChREBP at Thr(666) by PKA, Xenopus tropicalis" xref: Reactome:REACT_112409 "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA), Xenopus tropicalis" xref: Reactome:REACT_112611 "Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA, Xenopus tropicalis" xref: Reactome:REACT_113680 "Phosphorylation of PF2K-Pase by PKA catalytic subunit, Gallus gallus" xref: Reactome:REACT_114719 "PKA phosphorylates DARPP-32 on Thr34, Xenopus tropicalis" xref: Reactome:REACT_114883 "PKA phosphorylates PDE4B, Plasmodium falciparum" xref: Reactome:REACT_115177 "PKA phosphorylates PDE4B, Caenorhabditis elegans" xref: Reactome:REACT_115301 "PKA phosphorylates PDE4B, Dictyostelium discoideum" xref: Reactome:REACT_15519 "PKA phosphorylates PDE4B, Homo sapiens" xref: Reactome:REACT_15529 "PKA phosphorylates DARPP-32 on Thr34, Homo sapiens" xref: Reactome:REACT_1620 "Phosphorylation of mpChREBP (Thr 666) at Ser(196) by mPKA, Mus musculus" xref: Reactome:REACT_1761 "Phosphorylation of rPF2K-Pase by rPKA, Rattus norvegicus" xref: Reactome:REACT_2128 "Phosphorylation of PF2K-Pase by PKA catalytic subunit, Homo sapiens" xref: Reactome:REACT_23840 "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA), Homo sapiens" xref: Reactome:REACT_23999 "IL3RB is phosphorylated on Ser-585, Homo sapiens" xref: Reactome:REACT_28818 "Phosphorylation of PF2K-Pase by PKA catalytic subunit, Xenopus tropicalis" xref: Reactome:REACT_304 "Phosphorylation of ChREBP at Thr(666) by PKA, Homo sapiens" xref: Reactome:REACT_32440 "PKA phosphorylates DARPP-32 on Thr34, Sus scrofa" xref: Reactome:REACT_33420 "Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA, Canis familiaris" xref: Reactome:REACT_483 "Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA, Homo sapiens" xref: Reactome:REACT_523 "Phosphorylation of mChREBP at Thr (666) residue by mPKA, Mus musculus" xref: Reactome:REACT_77745 "Phosphorylation of ChREBP at Thr(666) by PKA, Bos taurus" xref: Reactome:REACT_77754 "Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA, Gallus gallus" xref: Reactome:REACT_79168 "PKA phosphorylates DARPP-32 on Thr34, Bos taurus" xref: Reactome:REACT_79281 "PKA phosphorylates DARPP-32 on Thr34, Danio rerio" xref: Reactome:REACT_79968 "Phosphorylation of ChREBP at Thr(666) by PKA, Taeniopygia guttata" xref: Reactome:REACT_80822 "PKA phosphorylates PDE4B, Rattus norvegicus" xref: Reactome:REACT_82788 "Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA, Danio rerio" xref: Reactome:REACT_86025 "PKA phosphorylates PDE4B, Xenopus tropicalis" xref: Reactome:REACT_86837 "Phosphorylation of PF2K-Pase by PKA catalytic subunit, Dictyostelium discoideum" xref: Reactome:REACT_86948 "Phosphorylation of PF2K-Pase by PKA catalytic subunit, Sus scrofa" xref: Reactome:REACT_87068 "PKA phosphorylates PDE4B, Bos taurus" xref: Reactome:REACT_87322 "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA), Taeniopygia guttata" xref: Reactome:REACT_88087 "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA), Saccharomyces cerevisiae" xref: Reactome:REACT_88176 "PKA phosphorylates PDE4B, Danio rerio" xref: Reactome:REACT_88555 "Phosphorylation of ChREBP at Thr(666) by PKA, Danio rerio" xref: Reactome:REACT_88759 "Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA, Taeniopygia guttata" xref: Reactome:REACT_89633 "PKA phosphorylates PDE4B, Canis familiaris" xref: Reactome:REACT_90568 "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA), Gallus gallus" xref: Reactome:REACT_92518 "Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA, Sus scrofa" xref: Reactome:REACT_93136 "Phosphorylation of PF2K-Pase by PKA catalytic subunit, Bos taurus" xref: Reactome:REACT_93846 "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA), Bos taurus" xref: Reactome:REACT_94203 "Phosphorylation of PF2K-Pase by PKA catalytic subunit, Saccharomyces cerevisiae" xref: Reactome:REACT_94372 "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA), Rattus norvegicus" xref: Reactome:REACT_95670 "Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA, Bos taurus" xref: Reactome:REACT_96593 "Phosphorylation of PF2K-Pase by PKA catalytic subunit, Mus musculus" xref: Reactome:REACT_97814 "Phosphorylation of ChREBP at Thr(666) by PKA, Canis familiaris" xref: Reactome:REACT_97831 "Phosphorylation of PF2K-Pase by PKA catalytic subunit, Danio rerio" xref: Reactome:REACT_98768 "PKA phosphorylates PDE4B, Sus scrofa" xref: Reactome:REACT_99116 "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA), Mus musculus" is_a: GO:0004690 ! cyclic nucleotide-dependent protein kinase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004721 name: phosphoprotein phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684] subset: gosubset_prok synonym: "phosphoprotein phosphohydrolase activity" EXACT [EC:3.1.3.16] synonym: "protein phosphatase activity" EXACT [] synonym: "protein phosphatase-1 activity" NARROW [EC:3.1.3.16] synonym: "protein phosphatase-2A activity" NARROW [EC:3.1.3.16] synonym: "protein phosphatase-2B activity" NARROW [EC:3.1.3.16] synonym: "protein phosphatase-2C activity" NARROW [EC:3.1.3.16] xref: EC:3.1.3.16 xref: MetaCyc:3.1.3.16-RXN xref: Reactome:REACT_100556 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Canis familiaris" xref: Reactome:REACT_101161 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Bos taurus" xref: Reactome:REACT_101258 "Dephosphorylation of phospho-Cdh1, Taeniopygia guttata" xref: Reactome:REACT_101308 "Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Mus musculus" xref: Reactome:REACT_101537 "Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Drosophila melanogaster" xref: Reactome:REACT_102055 "Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Bos taurus" xref: Reactome:REACT_102521 "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Canis familiaris" xref: Reactome:REACT_103107 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Danio rerio" xref: Reactome:REACT_105948 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Rattus norvegicus" xref: Reactome:REACT_106256 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Xenopus tropicalis" xref: Reactome:REACT_107500 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Taeniopygia guttata" xref: Reactome:REACT_107570 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Drosophila melanogaster" xref: Reactome:REACT_108174 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Gallus gallus" xref: Reactome:REACT_109144 "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Drosophila melanogaster" xref: Reactome:REACT_109225 "Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Rattus norvegicus" xref: Reactome:REACT_109310 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Rattus norvegicus" xref: Reactome:REACT_109345 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Mus musculus" xref: Reactome:REACT_109732 "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Rattus norvegicus" xref: Reactome:REACT_110596 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Canis familiaris" xref: Reactome:REACT_111148 "Dephosphorylation of p107 (RBL1) by PP2A, Homo sapiens" xref: Reactome:REACT_111170 "Dephosphorylation of p130 (RBL2) by PP2A, Homo sapiens" xref: Reactome:REACT_112020 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Drosophila melanogaster" xref: Reactome:REACT_112348 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Saccharomyces cerevisiae" xref: Reactome:REACT_112617 "Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Saccharomyces cerevisiae" xref: Reactome:REACT_112795 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Saccharomyces cerevisiae" xref: Reactome:REACT_112811 "Pp2a mediated localization of Rb protein in chromatin, Xenopus tropicalis" xref: Reactome:REACT_112981 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Schizosaccharomyces pombe" xref: Reactome:REACT_113855 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Schizosaccharomyces pombe" xref: Reactome:REACT_114200 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Schizosaccharomyces pombe" xref: Reactome:REACT_114550 "Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Schizosaccharomyces pombe" xref: Reactome:REACT_115084 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Saccharomyces cerevisiae" xref: Reactome:REACT_1251 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Homo sapiens" xref: Reactome:REACT_28268 "Dephosphorylation of phospho-Cdh1, Xenopus tropicalis" xref: Reactome:REACT_28473 "Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Canis familiaris" xref: Reactome:REACT_28474 "Pp2a mediated localization of Rb protein in chromatin, Canis familiaris" xref: Reactome:REACT_28606 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Gallus gallus" xref: Reactome:REACT_29645 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Mus musculus" xref: Reactome:REACT_30225 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Xenopus tropicalis" xref: Reactome:REACT_33423 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Drosophila melanogaster" xref: Reactome:REACT_421 "Pp2a mediated localization of Rb protein in chromatin, Homo sapiens" xref: Reactome:REACT_592 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Homo sapiens" xref: Reactome:REACT_59811 "Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Canis familiaris" xref: Reactome:REACT_6175 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Homo sapiens" xref: Reactome:REACT_6206 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Homo sapiens" xref: Reactome:REACT_6255 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Homo sapiens" xref: Reactome:REACT_6257 "Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Homo sapiens" xref: Reactome:REACT_6294 "Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Homo sapiens" xref: Reactome:REACT_6910 "Dephosphorylation of phospho-Cdh1, Homo sapiens" xref: Reactome:REACT_77578 "Dephosphorylation of phospho-Cdh1, Rattus norvegicus" xref: Reactome:REACT_77594 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Caenorhabditis elegans" xref: Reactome:REACT_77793 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Danio rerio" xref: Reactome:REACT_78412 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Mus musculus" xref: Reactome:REACT_78414 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Saccharomyces cerevisiae" xref: Reactome:REACT_80229 "Dephosphorylation of phospho-Cdh1, Bos taurus" xref: Reactome:REACT_80518 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Rattus norvegicus" xref: Reactome:REACT_81016 "Dephosphorylation of phospho-Cdh1, Sus scrofa" xref: Reactome:REACT_81195 "Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Xenopus tropicalis" xref: Reactome:REACT_81980 "Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Bos taurus" xref: Reactome:REACT_83073 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Xenopus tropicalis" xref: Reactome:REACT_83503 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Danio rerio" xref: Reactome:REACT_83605 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Dictyostelium discoideum" xref: Reactome:REACT_83812 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Drosophila melanogaster" xref: Reactome:REACT_83951 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Bos taurus" xref: Reactome:REACT_84291 "Pp2a mediated localization of Rb protein in chromatin, Mus musculus" xref: Reactome:REACT_84834 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Danio rerio" xref: Reactome:REACT_84882 "Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Gallus gallus" xref: Reactome:REACT_86262 "Dephosphorylation of phospho-Cdh1, Schizosaccharomyces pombe" xref: Reactome:REACT_86293 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Arabidopsis thaliana" xref: Reactome:REACT_86738 "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Xenopus tropicalis" xref: Reactome:REACT_89601 "Dephosphorylation of phospho-Cdh1, Gallus gallus" xref: Reactome:REACT_89607 "Dephosphorylation of cyclin B2:phospho-Cdc2 (Thr 14) by Cdc25, Xenopus tropicalis" xref: Reactome:REACT_9062 "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Homo sapiens" xref: Reactome:REACT_90978 "Pp2a mediated localization of Rb protein in chromatin, Taeniopygia guttata" xref: Reactome:REACT_91918 "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Danio rerio" xref: Reactome:REACT_91996 "Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Danio rerio" xref: Reactome:REACT_92154 "Dephosphorylation of phospho-Cdh1, Canis familiaris" xref: Reactome:REACT_92312 "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Bos taurus" xref: Reactome:REACT_92765 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Oryza sativa" xref: Reactome:REACT_93167 "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2, Mus musculus" xref: Reactome:REACT_93324 "Pp2a mediated localization of Rb protein in chromatin, Dictyostelium discoideum" xref: Reactome:REACT_94004 "Dephosphorylation of phospho-Cdh1, Danio rerio" xref: Reactome:REACT_95049 "Dephosphorylation of phospho-Cdh1, Mus musculus" xref: Reactome:REACT_95090 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Mus musculus" xref: Reactome:REACT_95688 "Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Drosophila melanogaster" xref: Reactome:REACT_95930 "Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Xenopus tropicalis" xref: Reactome:REACT_95992 "Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Mus musculus" xref: Reactome:REACT_97239 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Canis familiaris" xref: Reactome:REACT_97616 "Dephosphorylation of nuclear Cyclin A:phosph-Cdc2 complexes, Taeniopygia guttata" xref: Reactome:REACT_98140 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A, Bos taurus" xref: Reactome:REACT_98946 "Dephosphorylation of phospho-Cdh1, Saccharomyces cerevisiae" xref: Reactome:REACT_98958 "Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Rattus norvegicus" xref: Reactome:REACT_98967 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Schizosaccharomyces pombe" xref: Reactome:REACT_99508 "Dephosphorylation of cytoplasmic Cyclin B1:phospho-Cdc2 (Thr 14, Tyr 15) complexes by Cdc25 phosphatases, Danio rerio" xref: Reactome:REACT_99511 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein, Taeniopygia guttata" xref: Reactome:REACT_99512 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases, Rattus norvegicus" is_a: GO:0016791 ! phosphatase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004722 name: protein serine/threonine phosphatase activity namespace: molecular_function alt_id: GO:0000158 alt_id: GO:0000163 alt_id: GO:0008598 alt_id: GO:0008600 alt_id: GO:0015071 alt_id: GO:0030357 alt_id: GO:0030358 alt_id: GO:0030360 alt_id: GO:0030361 def: "Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf] subset: gosubset_prok synonym: "3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase" NARROW [EC:3.1.3.16] synonym: "Aspergillus awamori acid protein phosphatase" NARROW [EC:3.1.3.16] synonym: "BCKDH phosphatase" NARROW [EC:3.1.3.16] synonym: "branched-chain alpha-keto acid dehydrogenase phosphatase" NARROW [EC:3.1.3.16] synonym: "calcineurin" NARROW [] synonym: "casein phosphatase" NARROW [EC:3.1.3.16] synonym: "HMG-CoA reductase phosphatase" NARROW [EC:3.1.3.16] synonym: "phosphatase 2A" NARROW [EC:3.1.3.16] synonym: "phosphatase 2B" NARROW [EC:3.1.3.16] synonym: "phosphatase C-II" NARROW [EC:3.1.3.16] synonym: "phosphatase H-II" NARROW [EC:3.1.3.16] synonym: "phosphatase I" NARROW [EC:3.1.3.16] synonym: "phosphatase IB" NARROW [EC:3.1.3.16] synonym: "phosphatase II" NARROW [EC:3.1.3.16] synonym: "phosphatase III" NARROW [EC:3.1.3.16] synonym: "phosphatase IV" NARROW [EC:3.1.3.16] synonym: "phosphatase SP" NARROW [EC:3.1.3.16] synonym: "phosphopyruvate dehydrogenase phosphatase" NARROW [EC:3.1.3.16] synonym: "phosphospectrin phosphatase" NARROW [EC:3.1.3.16] synonym: "polycation modulated (PCM-) phosphatase" NARROW [EC:3.1.3.16] synonym: "protein D phosphatase" NARROW [EC:3.1.3.16] synonym: "protein phosphatase type 1 activity" NARROW [] synonym: "protein phosphatase type 1, intrinsic catalyst activity" NARROW [] synonym: "protein phosphatase type 2A activity" NARROW [] synonym: "protein phosphatase type 2A, intrinsic catalyst activity" NARROW [] synonym: "protein phosphatase type 2B activity" NARROW [] synonym: "protein phosphatase type 2B, intrinsic catalyst activity" NARROW [] synonym: "protein phosphatase type 2C activity" NARROW [] synonym: "protein phosphatase type 4 activity" NARROW [] synonym: "protein phosphatase type 4, intrinsic catalyst activity" NARROW [] synonym: "protein phosphatase X" NARROW [] synonym: "serine/threonine specific protein phosphatase activity" EXACT [] xref: Reactome:REACT_102328 "AMPK is dephosphorylated, Gallus gallus" xref: Reactome:REACT_103273 "AMPK is dephosphorylated, Danio rerio" xref: Reactome:REACT_104935 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate, Rattus norvegicus" xref: Reactome:REACT_105168 "ERKs are inactivated by protein phosphatase 2A, Bos taurus" xref: Reactome:REACT_105744 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate, Gallus gallus" xref: Reactome:REACT_106758 "phosphorylated perilipin + H2O -> perilipin + orthophosphate, Taeniopygia guttata" xref: Reactome:REACT_108076 "DARPP-32 is dephosphorylated on Thr34 by PP2B, Sus scrofa" xref: Reactome:REACT_108095 "phosphorylated perilipin + H2O -> perilipin + orthophosphate, Danio rerio" xref: Reactome:REACT_109701 "AMPK is dephosphorylated, Caenorhabditis elegans" xref: Reactome:REACT_110128 "AMPK is dephosphorylated, Sus scrofa" xref: Reactome:REACT_111094 "PPA2A dephosphorylates SPRY2, Homo sapiens" xref: Reactome:REACT_112525 "PHLPP dephosphorylates S473 in AKT, Gallus gallus" xref: Reactome:REACT_112659 "AMPK is dephosphorylated, Saccharomyces cerevisiae" xref: Reactome:REACT_113935 "PHLPP dephosphorylates S473 in AKT, Xenopus tropicalis" xref: Reactome:REACT_114990 "DARPP-32 is dephosphorylated on Thr34 by PP2B, Xenopus tropicalis" xref: Reactome:REACT_116150 "PP2B dephosphorylates DARPP-32 on T34, Rattus norvegicus" xref: Reactome:REACT_12403 "PHLPP dephosphorylates S473 in AKT, Homo sapiens" xref: Reactome:REACT_12539 "ERKs are inactivated by protein phosphatase 2A, Homo sapiens" xref: Reactome:REACT_15438 "DARPP-32 is dephosphorylated on Thr75 by PP2A, Homo sapiens" xref: Reactome:REACT_15494 "DARPP-32 is dephosphorylated on Thr34 by PP2B, Homo sapiens" xref: Reactome:REACT_1705 "phosphorylated perilipin + H2O -> perilipin + orthophosphate, Rattus norvegicus" xref: Reactome:REACT_19304 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate, Homo sapiens" xref: Reactome:REACT_21418 "AMPK is dephosphorylated, Homo sapiens" xref: Reactome:REACT_29362 "DARPP-32 is dephosphorylated on Thr75 by PP2A, Rattus norvegicus" xref: Reactome:REACT_30903 "DARPP-32 is dephosphorylated on Thr75 by PP2A, Canis familiaris" xref: Reactome:REACT_31424 "DARPP-32 is dephosphorylated on Thr75 by PP2A, Bos taurus" xref: Reactome:REACT_31944 "AMPK is dephosphorylated, Taeniopygia guttata" xref: Reactome:REACT_32258 "ERKs are inactivated by protein phosphatase 2A, Taeniopygia guttata" xref: Reactome:REACT_33433 "PHLPP dephosphorylates S473 in AKT, Rattus norvegicus" xref: Reactome:REACT_33609 "DARPP-32 is dephosphorylated on Thr34 by PP2B, Mus musculus" xref: Reactome:REACT_403 "phosphorylated perilipin + H2O -> perilipin + orthophosphate, Homo sapiens" xref: Reactome:REACT_60521 "phosphorylated perilipin + H2O -> perilipin + orthophosphate, Sus scrofa" xref: Reactome:REACT_75794 "Decay of mRNA in SMG6:SMG5:SMG7:mRNA Complex, Homo sapiens" xref: Reactome:REACT_77118 "DARPP-32 is dephosphorylated on Thr34 by PP2B, Bos taurus" xref: Reactome:REACT_77285 "PHLPP dephosphorylates S473 in AKT, Drosophila melanogaster" xref: Reactome:REACT_77773 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate, Bos taurus" xref: Reactome:REACT_79893 "AMPK is dephosphorylated, Drosophila melanogaster" xref: Reactome:REACT_80418 "PHLPP dephosphorylates S473 in AKT, Taeniopygia guttata" xref: Reactome:REACT_81032 "ERKs are inactivated by protein phosphatase 2A, Dictyostelium discoideum" xref: Reactome:REACT_82252 "AMPK is dephosphorylated, Mus musculus" xref: Reactome:REACT_82455 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate, Taeniopygia guttata" xref: Reactome:REACT_82736 "ERKs are inactivated by protein phosphatase 2A, Mus musculus" xref: Reactome:REACT_82848 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate, Danio rerio" xref: Reactome:REACT_83123 "AMPK is dephosphorylated, Canis familiaris" xref: Reactome:REACT_84149 "phosphorylated perilipin + H2O -> perilipin + orthophosphate, Canis familiaris" xref: Reactome:REACT_84173 "AMPK is dephosphorylated, Rattus norvegicus" xref: Reactome:REACT_87477 "phosphorylated perilipin + H2O -> perilipin + orthophosphate, Xenopus tropicalis" xref: Reactome:REACT_87535 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate, Mus musculus" xref: Reactome:REACT_87738 "ERKs are inactivated by protein phosphatase 2A, Rattus norvegicus" xref: Reactome:REACT_89253 "phosphorylated perilipin + H2O -> perilipin + orthophosphate, Mus musculus" xref: Reactome:REACT_92068 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate, Xenopus tropicalis" xref: Reactome:REACT_92797 "AMPK is dephosphorylated, Xenopus tropicalis" xref: Reactome:REACT_93522 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate, Drosophila melanogaster" xref: Reactome:REACT_93551 "PHLPP dephosphorylates S473 in AKT, Mus musculus" xref: Reactome:REACT_93922 "phosphorylated perilipin + H2O -> perilipin + orthophosphate, Bos taurus" xref: Reactome:REACT_94309 "ERKs are inactivated by protein phosphatase 2A, Drosophila melanogaster" xref: Reactome:REACT_94590 "ERKs are inactivated by protein phosphatase 2A, Canis familiaris" xref: Reactome:REACT_94855 "PHLPP dephosphorylates S473 in AKT, Canis familiaris" xref: Reactome:REACT_95676 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate, Canis familiaris" xref: Reactome:REACT_96055 "DARPP-32 is dephosphorylated on Thr34 by PP2B, Danio rerio" xref: Reactome:REACT_96980 "DARPP-32 is dephosphorylated on Thr75 by PP2A, Mus musculus" xref: Reactome:REACT_98890 "phosphorylated perilipin + H2O -> perilipin + orthophosphate, Gallus gallus" is_a: GO:0004721 ! phosphoprotein phosphatase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004733 name: pyridoxamine-phosphate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + hydrogen peroxide." [EC:1.4.3.5] subset: gosubset_prok synonym: "PdxH" RELATED [EC:1.4.3.5] synonym: "PMP oxidase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxal 5'-phosphate synthase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxamine 5'-phosphate oxidase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxamine phosphate oxidase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxamine-5'-phosphate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.5] synonym: "pyridoxaminephosphate oxidase (EC 1.4.3.5: deaminating)" EXACT [EC:1.4.3.5] synonym: "pyridoxine (pyridoxamine) 5'-phosphate oxidase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxine (pyridoxamine)phosphate oxidase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxol-5'-phosphate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.5] xref: EC:1.4.3.5 xref: MetaCyc:PMPOXI-RXN xref: Reactome:REACT_25127 "PLP from oxidation of pyridoxamine phosphate, Homo sapiens" xref: Reactome:REACT_25348 "PLP from oxidation of pyridoxine phosphate, Homo sapiens" xref: RHEA:15820 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor relationship: part_of GO:0042823 ! pyridoxal phosphate biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004738 name: pyruvate dehydrogenase activity namespace: molecular_function def: "Catalysis of the oxidative decarboxylation of pyruvate." [ISBN:0716020094] subset: gosubset_prok synonym: "pyruvic acid dehydrogenase activity" EXACT [EC:1.2.4.1] synonym: "pyruvic dehydrogenase activity" EXACT [EC:1.2.4.1] xref: MetaCyc:PYRUVOXID-RXN xref: MetaCyc:RXN0-1134 xref: Reactome:REACT_100036 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Schizosaccharomyces pombe" xref: Reactome:REACT_102216 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Xenopus tropicalis" xref: Reactome:REACT_102641 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Arabidopsis thaliana" xref: Reactome:REACT_108497 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Caenorhabditis elegans" xref: Reactome:REACT_109621 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Mus musculus" xref: Reactome:REACT_77363 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Taeniopygia guttata" xref: Reactome:REACT_81144 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Gallus gallus" xref: Reactome:REACT_85583 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Danio rerio" xref: Reactome:REACT_88103 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Sus scrofa" xref: Reactome:REACT_91141 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Dictyostelium discoideum" xref: Reactome:REACT_93329 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Canis familiaris" xref: Reactome:REACT_93801 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Bos taurus" xref: Reactome:REACT_95829 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Saccharomyces cerevisiae" xref: Reactome:REACT_96649 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Oryza sativa" xref: Reactome:REACT_96724 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Rattus norvegicus" xref: Reactome:REACT_983 "pyruvate + CoASH + NAD+ => acetylCoA + CO2 + NADH + H+, Homo sapiens" is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004753 name: saccharopine dehydrogenase activity namespace: molecular_function def: "Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor." [GOC:mah] subset: gosubset_prok synonym: "lysine-2-oxoglutarate reductase activity" EXACT [EC:1.5.1.-] synonym: "lysine-ketoglutarate reductase activity" EXACT [EC:1.5.1.-] xref: EC:1.5.1.- is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004784 name: superoxide dismutase activity namespace: molecular_function alt_id: GO:0004785 alt_id: GO:0008382 alt_id: GO:0008383 alt_id: GO:0016954 def: "Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." [EC:1.15.1.1, GOC:vw, PMID:15064408] subset: gosubset_prok synonym: "copper, zinc superoxide dismutase activity" NARROW [] synonym: "Cu,Zn-SOD" RELATED [EC:1.15.1.1] synonym: "Cu-Zn superoxide dismutase activity" NARROW [EC:1.15.1.1] synonym: "cuprein" RELATED [EC:1.15.1.1] synonym: "cytocuprein" RELATED [EC:1.15.1.1] synonym: "erythrocuprein" RELATED [EC:1.15.1.1] synonym: "Fe-SOD" RELATED [EC:1.15.1.1] synonym: "ferrisuperoxide dismutase activity" NARROW [EC:1.15.1.1] synonym: "hemocuprein" RELATED [EC:1.15.1.1] synonym: "hepatocuprein" RELATED [EC:1.15.1.1] synonym: "iron superoxide dismutase activity" NARROW [] synonym: "iron superoxide oxidoreductase" RELATED [] synonym: "manganese superoxide dismutase activity" NARROW [] synonym: "manganese superoxide oxidoreductase" RELATED [] synonym: "Mn, Fe superoxide dismutase" NARROW [] synonym: "Mn-SOD" RELATED [EC:1.15.1.1] synonym: "nickel superoxide dismutase activity" NARROW [] synonym: "nickel superoxide oxidoreductase" RELATED [] synonym: "SOD" RELATED [EC:1.15.1.1] synonym: "SOD-1" RELATED [EC:1.15.1.1] synonym: "SOD-2" RELATED [EC:1.15.1.1] synonym: "SOD-3" RELATED [EC:1.15.1.1] synonym: "SOD-4" RELATED [EC:1.15.1.1] synonym: "SODF" RELATED [EC:1.15.1.1] synonym: "SODS" RELATED [EC:1.15.1.1] synonym: "superoxide dismutase I" RELATED [EC:1.15.1.1] synonym: "superoxide dismutase II" RELATED [EC:1.15.1.1] synonym: "superoxide:superoxide oxidoreductase activity" EXACT [] synonym: "zinc superoxide oxidoreductase" RELATED [] xref: EC:1.15.1.1 xref: MetaCyc:SUPEROX-DISMUT-RXN xref: RHEA:20699 is_a: GO:0016209 ! antioxidant activity is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor relationship: part_of GO:0019430 ! removal of superoxide radicals property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004788 name: thiamine diphosphokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + thiamine = AMP + thiamine diphosphate." [EC:2.7.6.2] subset: gosubset_prok synonym: "ATP:thiamin pyrophosphotransferase activity" EXACT [EC:2.7.6.2] synonym: "ATP:thiamine diphosphotransferase activity" EXACT [EC:2.7.6.2] synonym: "thiamin diphosphokinase activity" EXACT [GOC:curators] synonym: "thiamin pyrophosphokinase activity" EXACT [] synonym: "thiamin pyrophosphotransferase activity" EXACT [EC:2.7.6.2] synonym: "thiamin:ATP pyrophosphotransferase activity" EXACT [EC:2.7.6.2] synonym: "thiamine pyrophosphokinase activity" EXACT [] synonym: "thiaminokinase activity" EXACT [EC:2.7.6.2] synonym: "TPTase activity" EXACT [EC:2.7.6.2] xref: EC:2.7.6.2 xref: MetaCyc:THIAMIN-PYROPHOSPHOKINASE-RXN xref: Reactome:REACT_102242 "Thiamin is pyrophosphorylated, Mus musculus" xref: Reactome:REACT_104766 "Thiamin is pyrophosphorylated, Canis familiaris" xref: Reactome:REACT_108061 "Thiamin is pyrophosphorylated, Saccharomyces cerevisiae" xref: Reactome:REACT_11233 "Thiamin is pyrophosphorylated, Homo sapiens" xref: Reactome:REACT_29181 "Thiamin is pyrophosphorylated, Oryza sativa" xref: Reactome:REACT_29244 "Thiamin is pyrophosphorylated, Bos taurus" xref: Reactome:REACT_30803 "Thiamin is pyrophosphorylated, Rattus norvegicus" xref: Reactome:REACT_32304 "Thiamin is pyrophosphorylated, Sus scrofa" xref: Reactome:REACT_32784 "Thiamin is pyrophosphorylated, Caenorhabditis elegans" xref: Reactome:REACT_78592 "Thiamin is pyrophosphorylated, Taeniopygia guttata" xref: Reactome:REACT_84784 "Thiamin is pyrophosphorylated, Xenopus tropicalis" xref: Reactome:REACT_87137 "Thiamin is pyrophosphorylated, Drosophila melanogaster" xref: Reactome:REACT_87156 "Thiamin is pyrophosphorylated, Danio rerio" xref: Reactome:REACT_89139 "Thiamin is pyrophosphorylated, Plasmodium falciparum" xref: Reactome:REACT_89462 "Thiamin is pyrophosphorylated, Arabidopsis thaliana" xref: Reactome:REACT_96391 "Thiamin is pyrophosphorylated, Dictyostelium discoideum" xref: Reactome:REACT_99319 "Thiamin is pyrophosphorylated, Gallus gallus" xref: RHEA:11579 is_a: GO:0016778 ! diphosphotransferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004791 name: thioredoxin-disulfide reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide." [EC:1.8.1.9, RHEA:20348] subset: gosubset_prok synonym: "NADP--thioredoxin reductase activity" EXACT [EC:1.8.1.9] synonym: "NADPH--thioredoxin reductase activity" EXACT [EC:1.8.1.9] synonym: "NADPH2:oxidized thioredoxin oxidoreductase activity" EXACT [EC:1.8.1.9] synonym: "NADPH:oxidized thioredoxin oxidoreductase activity" EXACT [EC:1.8.1.9] synonym: "thioredoxin disulfide reductase activity" EXACT [] synonym: "thioredoxin reductase (NADPH) activity" EXACT [] synonym: "thioredoxin-disulphide reductase activity" EXACT [] synonym: "thioredoxin:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.9] xref: EC:1.8.1.9 xref: KEGG:R02016 xref: MetaCyc:THIOREDOXIN-REDUCT-NADPH-RXN xref: Reactome:REACT_101101 "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+, Bos taurus" xref: Reactome:REACT_102076 "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+, Taeniopygia guttata" xref: Reactome:REACT_105790 "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+, Rattus norvegicus" xref: Reactome:REACT_114582 "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+, Caenorhabditis elegans" xref: Reactome:REACT_1609 "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+, Homo sapiens" xref: Reactome:REACT_54247 "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+, Mus musculus" xref: Reactome:REACT_79311 "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+, Gallus gallus" xref: Reactome:REACT_88338 "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+, Sus scrofa" xref: Reactome:REACT_94140 "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+, Canis familiaris" xref: Reactome:REACT_97505 "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+, Xenopus tropicalis" xref: RHEA:20348 is_a: GO:0016209 ! antioxidant activity is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004842 name: ubiquitin-protein transferase activity namespace: molecular_function alt_id: GO:0004840 alt_id: GO:0004841 def: "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] synonym: "anaphase-promoting complex activity" NARROW [GOC:dph, GOC:tb] synonym: "E2" RELATED [] synonym: "E3" RELATED [] synonym: "ubiquitin conjugating enzyme activity" NARROW [] synonym: "ubiquitin ligase activity" NARROW [] synonym: "ubiquitin protein ligase activity" NARROW [] synonym: "ubiquitin protein-ligase activity" NARROW [] synonym: "ubiquitin-conjugating enzyme activity" NARROW [] xref: KEGG:R03876 xref: MetaCyc:UBIQUITIN--PROTEIN-LIGASE-RXN xref: Reactome:REACT_100004 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Canis familiaris" xref: Reactome:REACT_100102 "Ubiquitination of stimulated EGFR (CBL:GRB2), Rattus norvegicus" xref: Reactome:REACT_100126 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8, Taeniopygia guttata" xref: Reactome:REACT_100359 "Monoubiquitination of FANCI by the FA ubiquitin ligase complex, Mus musculus" xref: Reactome:REACT_100699 "Activated TRAF6 recruits TAK1complex by binding to ubiquitin receptors of TAB2/TAB3, Sus scrofa" xref: Reactome:REACT_100823 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Mus musculus" xref: Reactome:REACT_100856 "CBL ubiquitinates Sprouty, Danio rerio" xref: Reactome:REACT_101110 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Mus musculus" xref: Reactome:REACT_101216 "CBL ubiquitinates Sprouty, Rattus norvegicus" xref: Reactome:REACT_101217 "CBL binds and ubiquitinates phosphorylated Sprouty, Rattus norvegicus" xref: Reactome:REACT_101822 "Ubiquitin-dependent degradation controls basal levels of SMAD2/3, Mus musculus" xref: Reactome:REACT_101849 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8, Drosophila melanogaster" xref: Reactome:REACT_102186 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8, Xenopus tropicalis" xref: Reactome:REACT_102220 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling, Xenopus tropicalis" xref: Reactome:REACT_102841 "Ubiquitination of stimulated EGFR (CBL:GRB2), Bos taurus" xref: Reactome:REACT_103261 "Autoubiquitination of phospho-COP1(Ser-387 ), Bos taurus" xref: Reactome:REACT_103376 "Ubiquitin-dependent degradation controls basal levels of SMAD2/3, Taeniopygia guttata" xref: Reactome:REACT_103483 "Ubiquitination of PER Proteins, Gallus gallus" xref: Reactome:REACT_103721 "CBL-mediated ubiquitination of CIN85, Rattus norvegicus" xref: Reactome:REACT_103809 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Xenopus tropicalis" xref: Reactome:REACT_104185 "Monoubiquitination of FANCD2 by the FA ubiquitin ligase complex, Canis familiaris" xref: Reactome:REACT_104518 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Taeniopygia guttata" xref: Reactome:REACT_104803 "CBL ubiquitinates Sprouty, Canis familiaris" xref: Reactome:REACT_104984 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8, Danio rerio" xref: Reactome:REACT_104994 "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling, Mus musculus" xref: Reactome:REACT_105370 "Multiubiquitination of APC/C-associated Cdh1, Danio rerio" xref: Reactome:REACT_105620 "Multiubiquitination of APC/C-associated Cdh1, Taeniopygia guttata" xref: Reactome:REACT_106156 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Rattus norvegicus" xref: Reactome:REACT_106407 "CBL binds and ubiquitinates phosphorylated Sprouty, Mus musculus" xref: Reactome:REACT_106416 "Ubiquitin-dependent degradation controls basal levels of SMAD2/3, Sus scrofa" xref: Reactome:REACT_106527 "Ubiquitin-dependent degradation controls basal levels of SMAD2/3, Gallus gallus" xref: Reactome:REACT_106906 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Xenopus tropicalis" xref: Reactome:REACT_107379 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Xenopus tropicalis" xref: Reactome:REACT_107643 "Ubiquitination of phospho-p27/p21, Danio rerio" xref: Reactome:REACT_107829 "Multiubiquitination of APC/C-associated Cdh1, Rattus norvegicus" xref: Reactome:REACT_108396 "TRAF6 polyubiquitinates NRIF, Bos taurus" xref: Reactome:REACT_108446 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Danio rerio" xref: Reactome:REACT_108589 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Mus musculus" xref: Reactome:REACT_108657 "Activated TRAF6 recruits TAK1complex by binding to ubiquitin receptors of TAB2/TAB3, Danio rerio" xref: Reactome:REACT_109007 "Monoubiquitination of FANCD2 by the FA ubiquitin ligase complex, Gallus gallus" xref: Reactome:REACT_109071 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Drosophila melanogaster" xref: Reactome:REACT_109354 "Ubiquitination of Emi1 by SCF-beta-TrCP, Rattus norvegicus" xref: Reactome:REACT_109539 "Ubiquitination of Emi1 by SCF-beta-TrCP, Canis familiaris" xref: Reactome:REACT_109637 "Autoubiquitination of phospho-COP1(Ser-387 ), Oryza sativa" xref: Reactome:REACT_109798 "CBL-mediated ubiquitination of CIN85, Mus musculus" xref: Reactome:REACT_110158 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Gallus gallus" xref: Reactome:REACT_110535 "Autoubiquitination of phospho-COP1(Ser-387 ), Xenopus tropicalis" xref: Reactome:REACT_110749 "Activated TRAF6 recruits TAK1complex by binding to ubiquitin receptors of TAB2/TAB3, Rattus norvegicus" xref: Reactome:REACT_111089 "Ubiquitination of p130 (RBL2) by SCF (Skp2), Homo sapiens" xref: Reactome:REACT_111141 "Phosphorylated SPRY2 is ubiquitinated by CBL, Homo sapiens" xref: Reactome:REACT_111231 "CBL ubiquitinates FRS2 and FGFR, Homo sapiens" xref: Reactome:REACT_112355 "Auto-ubiquitination of TRAF6, Bos taurus" xref: Reactome:REACT_112414 "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling, Danio rerio" xref: Reactome:REACT_112448 "Ubiquitination of NEMO by TRAF6, Xenopus tropicalis" xref: Reactome:REACT_112669 "CBL ubiquitinates Sprouty, Drosophila melanogaster" xref: Reactome:REACT_113192 "CBL ubiquitinates Sprouty, Bos taurus" xref: Reactome:REACT_113956 "Monoubiquitination of FANCI by the FA ubiquitin ligase complex, Xenopus tropicalis" xref: Reactome:REACT_114042 "Auto-ubiquitination of TRAF6, Gallus gallus" xref: Reactome:REACT_114074 "CBL ubiquitinates Sprouty, Gallus gallus" xref: Reactome:REACT_114376 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Oryza sativa" xref: Reactome:REACT_114678 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling, Danio rerio" xref: Reactome:REACT_115172 "Multiubiquitination of Nek2A, Dictyostelium discoideum" xref: Reactome:REACT_115175 "Ubiquitination of NEMO by TRAF6, Bos taurus" xref: Reactome:REACT_115543 "ISGylation of E2 conjugating enzymes, Homo sapiens" xref: Reactome:REACT_115557 "CUL5 mediates ubiquitination of ERBB2, Homo sapiens" xref: Reactome:REACT_115599 "RNF41 ubiquitinates activated ERBB3, Homo sapiens" xref: Reactome:REACT_115658 "ISGylation of host protein filamin B, Homo sapiens" xref: Reactome:REACT_115732 "Inefficient ubiquitination of ligand-responsive EGFR mutants by phosphorylated CBL, Homo sapiens" xref: Reactome:REACT_115802 "Monoubiquitination of FancD2, Gallus gallus" xref: Reactome:REACT_115843 "ISGylation of protein phosphatase 1 beta (PP2CB), Homo sapiens" xref: Reactome:REACT_115889 "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer, Homo sapiens" xref: Reactome:REACT_115890 "ISGylation of host proteins, Homo sapiens" xref: Reactome:REACT_115934 "ISGylation of IRF3, Homo sapiens" xref: Reactome:REACT_115952 "RNF41 ubiquitinates ERBB3, Homo sapiens" xref: Reactome:REACT_115963 "Self-ubiquitination of RNF41, Homo sapiens" xref: Reactome:REACT_115965 "ISGylation of viral protein NS1, Homo sapiens" xref: Reactome:REACT_116015 "CHIP (STUB1) mediates ubiquitination of ERBB2, Homo sapiens" xref: Reactome:REACT_116054 "ERBB4 ubiquitination by WWP1/ITCH, Homo sapiens" xref: Reactome:REACT_116086 "Monoubiquitination of PCNA, Gallus gallus" xref: Reactome:REACT_116132 "Activation of ISG15 by UBE1L E1 ligase, Homo sapiens" xref: Reactome:REACT_12038 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8, Homo sapiens" xref: Reactome:REACT_12048 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling, Homo sapiens" xref: Reactome:REACT_12381 "CBL ubiquitinates Sprouty, Homo sapiens" xref: Reactome:REACT_12432 "CBL binds and ubiquitinates phosphorylated Sprouty, Homo sapiens" xref: Reactome:REACT_12451 "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix, Homo sapiens" xref: Reactome:REACT_12515 "Ubiquitination of stimulated EGFR (CBL), Homo sapiens" xref: Reactome:REACT_12520 "CBL-mediated ubiquitination of CIN85, Homo sapiens" xref: Reactome:REACT_12553 "Ubiquitination of NEMO by TRAF6, Homo sapiens" xref: Reactome:REACT_12562 "Ubiquitination of stimulated EGFR (CBL:GRB2), Homo sapiens" xref: Reactome:REACT_12595 "Auto-ubiquitination of TRAF6, Homo sapiens" xref: Reactome:REACT_13487 "Ubiquitination of PAK-2p34, Oryctolagus cuniculus" xref: Reactome:REACT_13488 "TRAF6 polyubiquitinates NRIF, Homo sapiens" xref: Reactome:REACT_13600 "Ubiquitination of PAK-2p34, Homo sapiens" xref: Reactome:REACT_18367 "Monoubiquitination of FANCI by the FA ubiquitin ligase complex, Homo sapiens" xref: Reactome:REACT_18429 "Monoubiquitination of FANCD2 by the FA ubiquitin ligase complex, Homo sapiens" xref: Reactome:REACT_20581 "Autoubiquitination of phospho-COP1(Ser-387 ), Homo sapiens" xref: Reactome:REACT_21364 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation, Homo sapiens" xref: Reactome:REACT_22381 "Pellino ubiquitinates IRAK1, Homo sapiens" xref: Reactome:REACT_22407 "Beta-TrCP ubiquitinates then dissociates from p-NFKB p105, Homo sapiens" xref: Reactome:REACT_22430 "TRAF6 auto-ubiquitinates with Lys63-linked polyubiquitin chains, Homo sapiens" xref: Reactome:REACT_24932 "PIN1 mediated IRF3 degradation, Homo sapiens" xref: Reactome:REACT_24996 "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane, Homo sapiens" xref: Reactome:REACT_25022 "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2, Homo sapiens" xref: Reactome:REACT_25090 "TRAF6 ubiquitinqtes IRF7 in a K63-dependent manner following TLR7/8 or 9 stimulation, Homo sapiens" xref: Reactome:REACT_25128 "Auto ubiquitination of oligo TRAF6 bound to p-IRAK2, Gallus gallus" xref: Reactome:REACT_25143 "Ubiquitination of PER Proteins, Homo sapiens" xref: Reactome:REACT_25177 "RNF125 mediated ubiquitination of RIG-I, MDA5 and IPS-1, Mus musculus" xref: Reactome:REACT_25220 "K-63-linked polyubiquitination of RIG-I, Homo sapiens" xref: Reactome:REACT_25252 "RNF125 mediated ubiquitination of RIG-I, MDA5 and IPS-1, Homo sapiens" xref: Reactome:REACT_25317 "Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex dsRNA :TLR3 :TIKAM1, Gallus gallus" xref: Reactome:REACT_25362 "Activated TRAF6 synthesizes unanchored polyubiquitin chains, Homo sapiens" xref: Reactome:REACT_25377 "Auto ubiquitination of the TRAF6 within the complex viral dsRNA:TLR3:TIKAM1:TRAF6, Gallus gallus" xref: Reactome:REACT_25386 "Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex p-IRAK2:pUb_oligo TRAF6, Gallus gallus" xref: Reactome:REACT_25398 "Recruitment of AIP4 and K-48 ubiquitination of MAVS/IPS-1, Homo sapiens" xref: Reactome:REACT_27202 "Autoubiquitination of oligoTRAF6 bound to p-IRAK2, Gallus gallus" xref: Reactome:REACT_28038 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8, Mus musculus" xref: Reactome:REACT_28057 "Ubiquitination of NEMO by TRAF6, Danio rerio" xref: Reactome:REACT_28632 "Monoubiquitination of FANCI by the FA ubiquitin ligase complex, Gallus gallus" xref: Reactome:REACT_28669 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Drosophila melanogaster" xref: Reactome:REACT_28992 "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling, Bos taurus" xref: Reactome:REACT_29045 "CBL ubiquitinates Sprouty, Xenopus tropicalis" xref: Reactome:REACT_30173 "Monoubiquitination of FANCI by the FA ubiquitin ligase complex, Danio rerio" xref: Reactome:REACT_30590 "Ubiquitination of PER Proteins, Rattus norvegicus" xref: Reactome:REACT_30651 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8, Canis familiaris" xref: Reactome:REACT_30747 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Bos taurus" xref: Reactome:REACT_31133 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling, Bos taurus" xref: Reactome:REACT_31520 "TRAF6 polyubiquitinates NRIF, Gallus gallus" xref: Reactome:REACT_31622 "Monoubiquitination of FANCD2 by the FA ubiquitin ligase complex, Mus musculus" xref: Reactome:REACT_31985 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Danio rerio" xref: Reactome:REACT_32642 "CBL ubiquitinates Sprouty, Taeniopygia guttata" xref: Reactome:REACT_32728 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Gallus gallus" xref: Reactome:REACT_32748 "Multiubiquitination of APC/C-associated Cdh1, Mus musculus" xref: Reactome:REACT_33018 "Auto-ubiquitination of TRAF6, Xenopus tropicalis" xref: Reactome:REACT_33373 "Monoubiquitination of FANCI by the FA ubiquitin ligase complex, Taeniopygia guttata" xref: Reactome:REACT_33406 "Ubiquitination of NEMO by TRAF6, Mus musculus" xref: Reactome:REACT_33468 "Multiubiquitination of APC/C-associated Cdh1, Bos taurus" xref: Reactome:REACT_33488 "CBL binds and ubiquitinates phosphorylated Sprouty, Danio rerio" xref: Reactome:REACT_34498 "Multiubiquitination of Nek2A, Taeniopygia guttata" xref: Reactome:REACT_62571 "Ubiquitination of stimulated EGFR (CBL:GRB2), Gallus gallus" xref: Reactome:REACT_6723 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Homo sapiens" xref: Reactome:REACT_6735 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Homo sapiens" xref: Reactome:REACT_6786 "Ubiquitin-dependent degradation controls basal levels of SMAD2/3, Homo sapiens" xref: Reactome:REACT_6791 "Multiubiquitination of APC/C-associated Cdh1, Homo sapiens" xref: Reactome:REACT_6824 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Homo sapiens" xref: Reactome:REACT_6827 "Ubiquitination of Emi1 by SCF-beta-TrCP, Homo sapiens" xref: Reactome:REACT_6857 "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling, Homo sapiens" xref: Reactome:REACT_6914 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Homo sapiens" xref: Reactome:REACT_6921 "Activated TRAF6 recruits TAK1complex by binding to ubiquitin receptors of TAB2/TAB3, Homo sapiens" xref: Reactome:REACT_715 "Ubiquitination of Cyclin D1, Homo sapiens" xref: Reactome:REACT_75782 "E1 mediated ubiquitin activation, Homo sapiens" xref: Reactome:REACT_75847 "Polyubiquitination of substrate, Homo sapiens" xref: Reactome:REACT_75901 "Transfer of Ub from E2 to substrate and release of E2, Homo sapiens" xref: Reactome:REACT_75924 "RIP2 induces K63-linked ubiquitination of NEMO, Homo sapiens" xref: Reactome:REACT_76990 "Autoubiquitination of phospho-COP1(Ser-387 ), Gallus gallus" xref: Reactome:REACT_77058 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Bos taurus" xref: Reactome:REACT_78171 "Ubiquitin-dependent degradation controls basal levels of SMAD2/3, Canis familiaris" xref: Reactome:REACT_78216 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Rattus norvegicus" xref: Reactome:REACT_78347 "Ubiquitination of PER Proteins, Canis familiaris" xref: Reactome:REACT_78373 "Ubiquitination of stimulated EGFR (CBL), Xenopus tropicalis" xref: Reactome:REACT_78391 "TRAF6 polyubiquitinates NRIF, Mus musculus" xref: Reactome:REACT_78475 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Taeniopygia guttata" xref: Reactome:REACT_79393 "Multiubiquitination of APC/C-associated Cdh1, Drosophila melanogaster" xref: Reactome:REACT_79631 "Autoubiquitination of phospho-COP1(Ser-387 ), Danio rerio" xref: Reactome:REACT_79673 "Ubiquitination of phospho-p27/p21, Rattus norvegicus" xref: Reactome:REACT_79773 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Xenopus tropicalis" xref: Reactome:REACT_79781 "Multiubiquitination of APC/C-associated Cdh1, Oryza sativa" xref: Reactome:REACT_7995 "Multiubiquitination of Nek2A, Homo sapiens" xref: Reactome:REACT_80157 "Multiubiquitination of APC/C-associated Cdh1, Xenopus tropicalis" xref: Reactome:REACT_80228 "Monoubiquitination of FANCI by the FA ubiquitin ligase complex, Rattus norvegicus" xref: Reactome:REACT_80230 "Auto-ubiquitination of TRAF6, Mus musculus" xref: Reactome:REACT_80243 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Taeniopygia guttata" xref: Reactome:REACT_80572 "CBL-mediated ubiquitination of CIN85, Taeniopygia guttata" xref: Reactome:REACT_80798 "Autoubiquitination of phospho-COP1(Ser-387 ), Canis familiaris" xref: Reactome:REACT_80813 "Ubiquitin-dependent degradation controls basal levels of SMAD2/3, Rattus norvegicus" xref: Reactome:REACT_81041 "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix, Mus musculus" xref: Reactome:REACT_81332 "Ubiquitination of phospho-p27/p21, Mus musculus" xref: Reactome:REACT_81489 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8, Bos taurus" xref: Reactome:REACT_81526 "Ubiquitin-dependent degradation controls basal levels of SMAD2/3, Bos taurus" xref: Reactome:REACT_81796 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Canis familiaris" xref: Reactome:REACT_81809 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Gallus gallus" xref: Reactome:REACT_82103 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling, Sus scrofa" xref: Reactome:REACT_82502 "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling, Xenopus tropicalis" xref: Reactome:REACT_82956 "CBL-mediated ubiquitination of CIN85, Bos taurus" xref: Reactome:REACT_83121 "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling, Drosophila melanogaster" xref: Reactome:REACT_83886 "Ubiquitination of Emi1 by SCF-beta-TrCP, Mus musculus" xref: Reactome:REACT_83914 "Ubiquitination of phospho-p27/p21, Bos taurus" xref: Reactome:REACT_84110 "Multiubiquitination of Nek2A, Drosophila melanogaster" xref: Reactome:REACT_84282 "Ubiquitination of stimulated EGFR (CBL), Danio rerio" xref: Reactome:REACT_84479 "Multiubiquitination of Nek2A, Rattus norvegicus" xref: Reactome:REACT_84482 "Multiubiquitination of Nek2A, Xenopus tropicalis" xref: Reactome:REACT_84826 "Ubiquitination of stimulated EGFR (CBL), Mus musculus" xref: Reactome:REACT_85057 "Autoubiquitination of phospho-COP1(Ser-387 ), Taeniopygia guttata" xref: Reactome:REACT_85163 "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling, Rattus norvegicus" xref: Reactome:REACT_85194 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Drosophila melanogaster" xref: Reactome:REACT_85337 "CBL binds and ubiquitinates phosphorylated Sprouty, Canis familiaris" xref: Reactome:REACT_85348 "CBL-mediated ubiquitination of CIN85, Gallus gallus" xref: Reactome:REACT_85498 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8, Rattus norvegicus" xref: Reactome:REACT_86043 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Danio rerio" xref: Reactome:REACT_86192 "Ubiquitination of phospho-p27/p21, Canis familiaris" xref: Reactome:REACT_86281 "Ubiquitination of Emi1 by SCF-beta-TrCP, Bos taurus" xref: Reactome:REACT_86879 "Ubiquitin-dependent degradation controls basal levels of SMAD2/3, Danio rerio" xref: Reactome:REACT_87217 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Gallus gallus" xref: Reactome:REACT_87236 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling, Mus musculus" xref: Reactome:REACT_87349 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Taeniopygia guttata" xref: Reactome:REACT_87486 "Monoubiquitination of FANCI by the FA ubiquitin ligase complex, Bos taurus" xref: Reactome:REACT_87663 "Multiubiquitination of Nek2A, Gallus gallus" xref: Reactome:REACT_87845 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling, Rattus norvegicus" xref: Reactome:REACT_88589 "Autoubiquitination of phospho-COP1(Ser-387 ), Rattus norvegicus" xref: Reactome:REACT_88911 "CBL ubiquitinates Sprouty, Mus musculus" xref: Reactome:REACT_88971 "Monoubiquitination of FANCD2 by the FA ubiquitin ligase complex, Rattus norvegicus" xref: Reactome:REACT_89066 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex, Mus musculus" xref: Reactome:REACT_89086 "Ubiquitination of stimulated EGFR (CBL), Canis familiaris" xref: Reactome:REACT_89128 "TRAF6 polyubiquitinates NRIF, Rattus norvegicus" xref: Reactome:REACT_89304 "Ubiquitination of Emi1 by SCF-beta-TrCP, Drosophila melanogaster" xref: Reactome:REACT_89324 "CBL-mediated ubiquitination of CIN85, Danio rerio" xref: Reactome:REACT_89540 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling, Drosophila melanogaster" xref: Reactome:REACT_9026 "Ubiquitination of phospho-p27/p21, Homo sapiens" xref: Reactome:REACT_90441 "CBL-mediated ubiquitination of CIN85, Canis familiaris" xref: Reactome:REACT_90505 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8, Gallus gallus" xref: Reactome:REACT_9063 "Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex, Homo sapiens" xref: Reactome:REACT_90742 "Ubiquitination of PER Proteins, Drosophila melanogaster" xref: Reactome:REACT_90880 "Monoubiquitination of FANCD2 by the FA ubiquitin ligase complex, Danio rerio" xref: Reactome:REACT_91216 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Oryza sativa" xref: Reactome:REACT_91336 "Multiubiquitination of APC/C-associated Cdh1, Gallus gallus" xref: Reactome:REACT_91446 "Ubiquitination of stimulated EGFR (CBL:GRB2), Xenopus tropicalis" xref: Reactome:REACT_91686 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Bos taurus" xref: Reactome:REACT_91754 "Multiubiquitination of Nek2A, Danio rerio" xref: Reactome:REACT_91854 "Activated TRAF6 recruits TAK1complex by binding to ubiquitin receptors of TAB2/TAB3, Bos taurus" xref: Reactome:REACT_91885 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Rattus norvegicus" xref: Reactome:REACT_92022 "Multiubiquitination of Nek2A, Bos taurus" xref: Reactome:REACT_92097 "Activated TRAF6 recruits TAK1complex by binding to ubiquitin receptors of TAB2/TAB3, Gallus gallus" xref: Reactome:REACT_92278 "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix, Rattus norvegicus" xref: Reactome:REACT_92341 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Dictyostelium discoideum" xref: Reactome:REACT_92445 "CBL binds and ubiquitinates phosphorylated Sprouty, Xenopus tropicalis" xref: Reactome:REACT_92638 "Autoubiquitination of phospho-COP1(Ser-387 ), Sus scrofa" xref: Reactome:REACT_92641 "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling, Sus scrofa" xref: Reactome:REACT_92734 "Autoubiquitination of phospho-COP1(Ser-387 ), Dictyostelium discoideum" xref: Reactome:REACT_92878 "Multiubiquitination of APC/C-associated Cdh1, Canis familiaris" xref: Reactome:REACT_93 "Ubiquitination of phosphorylated Cdc25A, Homo sapiens" xref: Reactome:REACT_93088 "Autoubiquitination of phospho-COP1(Ser-387 ), Mus musculus" xref: Reactome:REACT_93091 "Monoubiquitination of FANCI by the FA ubiquitin ligase complex, Canis familiaris" xref: Reactome:REACT_93808 "Ubiquitination of stimulated EGFR (CBL:GRB2), Danio rerio" xref: Reactome:REACT_93823 "Ubiquitination of PER Proteins, Xenopus tropicalis" xref: Reactome:REACT_93940 "CBL-mediated ubiquitination of CIN85, Drosophila melanogaster" xref: Reactome:REACT_93965 "Monoubiquitination of FANCD2 by the FA ubiquitin ligase complex, Bos taurus" xref: Reactome:REACT_94143 "TRAF6 polyubiquitinates NRIF, Taeniopygia guttata" xref: Reactome:REACT_94165 "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix, Danio rerio" xref: Reactome:REACT_94183 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8, Sus scrofa" xref: Reactome:REACT_94202 "Multiubiquitination of Nek2A, Canis familiaris" xref: Reactome:REACT_94479 "Ubiquitination of PER Proteins, Bos taurus" xref: Reactome:REACT_94486 "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling, Canis familiaris" xref: Reactome:REACT_94525 "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix, Xenopus tropicalis" xref: Reactome:REACT_94687 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Bos taurus" xref: Reactome:REACT_9471 "Multi-ubiquitination of APOBEC3G, Homo sapiens" xref: Reactome:REACT_94788 "Monoubiquitination of FANCD2 by the FA ubiquitin ligase complex, Taeniopygia guttata" xref: Reactome:REACT_94789 "Ubiquitin-dependent degradation controls basal levels of SMAD2/3, Drosophila melanogaster" xref: Reactome:REACT_94816 "Activated TRAF6 recruits TAK1complex by binding to ubiquitin receptors of TAB2/TAB3, Taeniopygia guttata" xref: Reactome:REACT_94864 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex, Canis familiaris" xref: Reactome:REACT_95005 "Ubiquitination of phospho-p27/p21, Sus scrofa" xref: Reactome:REACT_95022 "Multiubiquitination of Nek2A, Mus musculus" xref: Reactome:REACT_95267 "Ubiquitination of phospho-p27/p21, Xenopus tropicalis" xref: Reactome:REACT_95302 "Ubiquitination of Emi1 by SCF-beta-TrCP, Taeniopygia guttata" xref: Reactome:REACT_95501 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex, Canis familiaris" xref: Reactome:REACT_95529 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling, Canis familiaris" xref: Reactome:REACT_95866 "Ubiquitination of stimulated EGFR (CBL:GRB2), Taeniopygia guttata" xref: Reactome:REACT_96059 "Ubiquitination of stimulated EGFR (CBL:GRB2), Canis familiaris" xref: Reactome:REACT_96134 "Activated TRAF6 recruits TAK1complex by binding to ubiquitin receptors of TAB2/TAB3, Xenopus tropicalis" xref: Reactome:REACT_96591 "CBL-mediated ubiquitination of CIN85, Xenopus tropicalis" xref: Reactome:REACT_96771 "Ubiquitin-dependent degradation controls basal levels of SMAD2/3, Xenopus tropicalis" xref: Reactome:REACT_97330 "Ubiquitination of Emi1 by SCF-beta-TrCP, Xenopus tropicalis" xref: Reactome:REACT_97494 "Ubiquitination of stimulated EGFR (CBL:GRB2), Mus musculus" xref: Reactome:REACT_97971 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Drosophila melanogaster" xref: Reactome:REACT_98364 "Auto-ubiquitination of TRAF6, Danio rerio" xref: Reactome:REACT_98491 "Activated TRAF6 recruits TAK1complex by binding to ubiquitin receptors of TAB2/TAB3, Mus musculus" xref: Reactome:REACT_98502 "Activated TRAF6 recruits TAK1complex by binding to ubiquitin receptors of TAB2/TAB3, Canis familiaris" xref: Reactome:REACT_98894 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Rattus norvegicus" xref: Reactome:REACT_98993 "Ubiquitination of PER Proteins, Taeniopygia guttata" xref: Reactome:REACT_99285 "Ubiquitination of stimulated EGFR (CBL), Rattus norvegicus" xref: Reactome:REACT_99567 "Ubiquitination of Emi1 by SCF-beta-TrCP, Gallus gallus" xref: Reactome:REACT_99825 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex, Danio rerio" is_a: GO:0019787 ! ubiquitin-like protein transferase activity relationship: part_of GO:0016567 ! protein ubiquitination property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0004844 name: uracil DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine." [GOC:elh, GOC:pr, PMID:9224623] subset: gosubset_prok synonym: "uracil-DNA glycosylase activity" EXACT [] xref: EC:3.2.2.- xref: Reactome:REACT_1015 "Cleavage of 5-hydroxyluracil by UNG2 glycosylase, Homo sapiens" xref: Reactome:REACT_104182 "Cleavage of uracil by UNG2 glycosylase, Mus musculus" xref: Reactome:REACT_104724 "Cleavage of uracil by UNG2 glycosylase, Sus scrofa" xref: Reactome:REACT_105882 "Cleavage of 5-hydroxyluracil by UNG2 glycosylase, Sus scrofa" xref: Reactome:REACT_107541 "Cleavage of 5-hydroxyluracil by UNG2 glycosylase, Xenopus tropicalis" xref: Reactome:REACT_115592 "Cleavage of uracil by Uracil-glycosylase, Gallus gallus" xref: Reactome:REACT_115960 "Uracil glycosylase mediated recognition and binding of uracil opposite guanine, Gallus gallus" xref: Reactome:REACT_239 "Cleavage of uracil by UNG2 glycosylase, Homo sapiens" xref: Reactome:REACT_32493 "Cleavage of uracil by UNG2 glycosylase, Rattus norvegicus" xref: Reactome:REACT_79037 "Cleavage of uracil by UNG2 glycosylase, Canis familiaris" xref: Reactome:REACT_79415 "Cleavage of 5-hydroxyluracil by UNG2 glycosylase, Canis familiaris" xref: Reactome:REACT_80373 "Cleavage of 5-hydroxyluracil by UNG2 glycosylase, Mus musculus" xref: Reactome:REACT_91708 "Cleavage of uracil by UNG2 glycosylase, Xenopus tropicalis" xref: Reactome:REACT_92819 "Cleavage of 5-hydroxyluracil by UNG2 glycosylase, Rattus norvegicus" is_a: GO:0097506 ! deaminated base DNA N-glycosylase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005215 name: transporter activity namespace: molecular_function alt_id: GO:0005478 def: "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "small-molecule carrier or transporter" RELATED [] xref: Reactome:REACT_6315 "Virion-associated M2 protein mediated ion infusion, Homo sapiens" is_a: GO:0003674 ! molecular_function relationship: part_of GO:0006810 ! transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005451 name: monovalent cation:proton antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent cation(out) + H+(in) = monovalent cation(in) + H+(out)." [GOC:ai] subset: gosubset_prok synonym: "monovalent cation:hydrogen antiporter activity" EXACT [] is_a: GO:0015299 ! solute:proton antiporter activity is_a: GO:0015491 ! cation:cation antiporter activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005488 name: binding namespace: molecular_function def: "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732] comment: Note that this term is in the subset of terms that should not be used for direct, manual gene product annotation. Please choose a more specific child term, or request a new one if no suitable term is available. For ligands that bind to signal transducing receptors, consider the molecular function term 'receptor binding ; GO:0005102' and its children. subset: gocheck_do_not_manually_annotate subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "ligand" NARROW [] xref: Wikipedia:Binding_(molecular) is_a: GO:0003674 ! molecular_function property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005496 name: steroid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene." [GOC:jl, ISBN:0198506732] subset: goslim_pir subset: gosubset_prok is_a: GO:0008289 ! lipid binding is_a: GO:0097159 ! organic cyclic compound binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005504 name: fatty acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198506732] subset: gosubset_prok is_a: GO:0008289 ! lipid binding is_a: GO:0033293 ! monocarboxylic acid binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005515 name: protein binding namespace: molecular_function alt_id: GO:0045308 def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "alpha-2 macroglobulin receptor-associated protein activity" RELATED [] synonym: "protein amino acid binding" EXACT [] synonym: "protein degradation tagging activity" RELATED [] synonym: "protein folding chaperone" NARROW [GOC:dph, GOC:mah, GOC:tb] synonym: "protein tagging activity" RELATED [] xref: Reactome:REACT_100287 "Formation of the IGF:IGFBP-4 Complex, Canis familiaris" xref: Reactome:REACT_101129 "Formation of the IGF:IGFBP-3:ALS Complex, Rattus norvegicus" xref: Reactome:REACT_102084 "Formation of the IGF:IGFBP-5:ALS Complex, Mus musculus" xref: Reactome:REACT_102457 "An anchoring protein, SARA, recruits SMAD2/3, Canis familiaris" xref: Reactome:REACT_103972 "Type II receptor recruits type I receptor, Xenopus tropicalis" xref: Reactome:REACT_104029 "Formation of the IGF:IGFBP-6 Complex, Bos taurus" xref: Reactome:REACT_104599 "Type II receptor recruits type I receptor, Sus scrofa" xref: Reactome:REACT_105776 "Formation of the IGF:IGFBP-3:ALS Complex, Danio rerio" xref: Reactome:REACT_105895 "Formation of the IGF:IGFBP-4 Complex, Bos taurus" xref: Reactome:REACT_106168 "Formation of the IGF:IGFBP-2 Complex, Bos taurus" xref: Reactome:REACT_106189 "Formation of the IGF:IGFBP-5:ALS Complex, Gallus gallus" xref: Reactome:REACT_107402 "Formation of the IGF:IGFBP-4 Complex, Mus musculus" xref: Reactome:REACT_108283 "Formation of the IGF:IGFBP-4 Complex, Xenopus tropicalis" xref: Reactome:REACT_109392 "Formation of the IGF:IGFBP-3:ALS Complex, Gallus gallus" xref: Reactome:REACT_110419 "Type II receptor recruits type I receptor, Bos taurus" xref: Reactome:REACT_110570 "Formation of the IGF:IGFBP-3:ALS Complex, Sus scrofa" xref: Reactome:REACT_15321 "Formation of the IGF:IGFBP-1 Complex, Homo sapiens" xref: Reactome:REACT_15325 "Formation of the IGF:IGFBP-4 Complex, Homo sapiens" xref: Reactome:REACT_15355 "Formation of the IGF:IGFBP-5:ALS Complex, Homo sapiens" xref: Reactome:REACT_15417 "Formation of the IGF:IGFBP-3:ALS Complex, Homo sapiens" xref: Reactome:REACT_15419 "Formation of the IGF:IGFBP-2 Complex, Homo sapiens" xref: Reactome:REACT_15506 "Formation of the IGF:IGFBP-6 Complex, Homo sapiens" xref: Reactome:REACT_15541 "Traversal of the cortical actin network and docking at plasma membrane, Homo sapiens" xref: Reactome:REACT_20509 "Exocytosis of Insulin, Mus musculus" xref: Reactome:REACT_20539 "Traversal of the cortical actin network., Mus musculus" xref: Reactome:REACT_28794 "Formation of the IGF:IGFBP-4 Complex, Sus scrofa" xref: Reactome:REACT_30571 "Formation of the IGF:IGFBP-6 Complex, Danio rerio" xref: Reactome:REACT_30672 "Formation of the IGF:IGFBP-2 Complex, Taeniopygia guttata" xref: Reactome:REACT_31305 "Formation of the IGF:IGFBP-3:ALS Complex, Taeniopygia guttata" xref: Reactome:REACT_31537 "Formation of the IGF:IGFBP-6 Complex, Rattus norvegicus" xref: Reactome:REACT_31641 "Type II receptor recruits type I receptor, Danio rerio" xref: Reactome:REACT_31648 "An anchoring protein, SARA, recruits SMAD2/3, Mus musculus" xref: Reactome:REACT_32973 "Formation of the IGF:IGFBP-1 Complex, Canis familiaris" xref: Reactome:REACT_33135 "An anchoring protein, SARA, recruits SMAD2/3, Rattus norvegicus" xref: Reactome:REACT_34719 "Formation of the IGF:IGFBP-1 Complex, Danio rerio" xref: Reactome:REACT_6923 "An anchoring protein, SARA, recruits SMAD2/3, Homo sapiens" xref: Reactome:REACT_6945 "Type II receptor recruits type I receptor, Homo sapiens" xref: Reactome:REACT_78382 "Formation of the IGF:IGFBP-1 Complex, Mus musculus" xref: Reactome:REACT_78466 "Formation of the IGF:IGFBP-6 Complex, Canis familiaris" xref: Reactome:REACT_79634 "Formation of the IGF:IGFBP-5:ALS Complex, Canis familiaris" xref: Reactome:REACT_80470 "Formation of the IGF:IGFBP-1 Complex, Rattus norvegicus" xref: Reactome:REACT_80778 "Type II receptor recruits type I receptor, Mus musculus" xref: Reactome:REACT_83147 "Type II receptor recruits type I receptor, Rattus norvegicus" xref: Reactome:REACT_83165 "Formation of the IGF:IGFBP-5:ALS Complex, Sus scrofa" xref: Reactome:REACT_83532 "Formation of the IGF:IGFBP-2 Complex, Xenopus tropicalis" xref: Reactome:REACT_85250 "Formation of the IGF:IGFBP-2 Complex, Canis familiaris" xref: Reactome:REACT_85858 "Formation of the IGF:IGFBP-2 Complex, Gallus gallus" xref: Reactome:REACT_85975 "An anchoring protein, SARA, recruits SMAD2/3, Danio rerio" xref: Reactome:REACT_87187 "An anchoring protein, SARA, recruits SMAD2/3, Xenopus tropicalis" xref: Reactome:REACT_87374 "Formation of the IGF:IGFBP-6 Complex, Sus scrofa" xref: Reactome:REACT_87652 "Formation of the IGF:IGFBP-5:ALS Complex, Bos taurus" xref: Reactome:REACT_88068 "Formation of the IGF:IGFBP-3:ALS Complex, Canis familiaris" xref: Reactome:REACT_88138 "Formation of the IGF:IGFBP-5:ALS Complex, Danio rerio" xref: Reactome:REACT_88223 "Formation of the IGF:IGFBP-1 Complex, Sus scrofa" xref: Reactome:REACT_89261 "Formation of the IGF:IGFBP-4 Complex, Taeniopygia guttata" xref: Reactome:REACT_90027 "Formation of the IGF:IGFBP-2 Complex, Rattus norvegicus" xref: Reactome:REACT_90105 "Formation of the IGF:IGFBP-1 Complex, Xenopus tropicalis" xref: Reactome:REACT_90666 "An anchoring protein, SARA, recruits SMAD2/3, Sus scrofa" xref: Reactome:REACT_91560 "Type II receptor recruits type I receptor, Canis familiaris" xref: Reactome:REACT_92029 "Formation of the IGF:IGFBP-4 Complex, Rattus norvegicus" xref: Reactome:REACT_93175 "Formation of the IGF:IGFBP-1 Complex, Gallus gallus" xref: Reactome:REACT_93938 "Formation of the IGF:IGFBP-5:ALS Complex, Rattus norvegicus" xref: Reactome:REACT_94522 "Formation of the IGF:IGFBP-5:ALS Complex, Taeniopygia guttata" xref: Reactome:REACT_94808 "Formation of the IGF:IGFBP-6 Complex, Mus musculus" xref: Reactome:REACT_95241 "Formation of the IGF:IGFBP-3:ALS Complex, Mus musculus" xref: Reactome:REACT_95561 "Formation of the IGF:IGFBP-5:ALS Complex, Xenopus tropicalis" xref: Reactome:REACT_95647 "Formation of the IGF:IGFBP-3:ALS Complex, Bos taurus" xref: Reactome:REACT_96236 "Formation of the IGF:IGFBP-2 Complex, Mus musculus" xref: Reactome:REACT_96264 "Formation of the IGF:IGFBP-2 Complex, Danio rerio" xref: Reactome:REACT_98028 "Formation of the IGF:IGFBP-1 Complex, Taeniopygia guttata" xref: Reactome:REACT_98807 "An anchoring protein, SARA, recruits SMAD2/3, Bos taurus" is_a: GO:0005488 ! binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005524 name: ATP binding namespace: molecular_function def: "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] subset: gosubset_prok xref: Reactome:REACT_102029 "Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels), Bos taurus" xref: Reactome:REACT_107997 "Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels), Taeniopygia guttata" xref: Reactome:REACT_115254 "Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels), Drosophila melanogaster" xref: Reactome:REACT_16883 "Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels), Homo sapiens" xref: Reactome:REACT_29298 "Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels), Danio rerio" xref: Reactome:REACT_79910 "Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels), Gallus gallus" xref: Reactome:REACT_85335 "Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels), Canis familiaris" xref: Reactome:REACT_93991 "Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels), Mus musculus" xref: Reactome:REACT_99051 "Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels), Sus scrofa" xref: Reactome:REACT_99955 "Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels), Rattus norvegicus" is_a: GO:0032550 ! purine ribonucleoside binding is_a: GO:0032559 ! adenyl ribonucleotide binding is_a: GO:0035639 ! purine ribonucleoside triphosphate binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005525 name: GTP binding namespace: molecular_function def: "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] subset: gosubset_prok xref: Reactome:REACT_100336 "The receptor:G-protein complex binds GTP, Xenopus tropicalis" xref: Reactome:REACT_101169 "The receptor:G-protein complex binds GTP, Rattus norvegicus" xref: Reactome:REACT_15491 "The receptor:G-protein complex binds GTP, Homo sapiens" xref: Reactome:REACT_28426 "The receptor:G-protein complex binds GTP, Sus scrofa" xref: Reactome:REACT_32895 "The receptor:G-protein complex binds GTP, Taeniopygia guttata" xref: Reactome:REACT_84605 "The receptor:G-protein complex binds GTP, Gallus gallus" xref: Reactome:REACT_84948 "The receptor:G-protein complex binds GTP, Bos taurus" xref: Reactome:REACT_87202 "The receptor:G-protein complex binds GTP, Canis familiaris" xref: Reactome:REACT_87916 "The receptor:G-protein complex binds GTP, Danio rerio" xref: Reactome:REACT_90887 "The receptor:G-protein complex binds GTP, Mus musculus" is_a: GO:0032550 ! purine ribonucleoside binding is_a: GO:0032561 ! guanyl ribonucleotide binding is_a: GO:0035639 ! purine ribonucleoside triphosphate binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005534 name: galactose binding namespace: molecular_function def: "Interacting selectively and non-covalently with the aldohexose galactose (galacto-hexose), a common constituent of many oligo- and polysaccharides." [CHEBI:28260, GOC:jl, ISBN:0198506732] subset: gosubset_prok synonym: "galactose binding lectin" RELATED [] is_a: GO:0048029 ! monosaccharide binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005536 name: glucose binding namespace: molecular_function def: "Interacting selectively and non-covalently with the D- or L-enantiomer of glucose." [CHEBI:17234, GOC:jl] subset: gosubset_prok is_a: GO:0048029 ! monosaccharide binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005537 name: mannose binding namespace: molecular_function def: "Interacting selectively and non-covalently with mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans." [CHEBI:37684, GOC:jl, ISBN:0192800981] subset: goslim_chembl subset: gosubset_prok synonym: "mannose binding lectin" RELATED [] xref: Reactome:REACT_25176 "Transport of glycoproteins with Man8 (or Man9) N-glycans to the Golgi, Homo sapiens" is_a: GO:0048029 ! monosaccharide binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005575 name: cellular_component namespace: cellular_component alt_id: GO:0008372 def: "The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together." [GOC:go_curators, NIF_Subcellular:sao-1337158144] comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. Note that when this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "cell or subcellular entity" EXACT [] synonym: "cellular component" EXACT [] synonym: "subcellular entity" RELATED [NIF_Subcellular:nlx_subcell_100315] xref: NIF_Subcellular:sao-1337158144 xref: NIF_Subcellular:sao1337158144 property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005618 name: cell wall namespace: cellular_component def: "The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins." [GOC:giardia, http://en.wikipedia.org/wiki/Microbial_cyst, ISBN:0198547684, PMID:15134259] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: Wikipedia:Cell_wall is_a: GO:0030312 ! external encapsulating structure property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005619 name: ascospore wall namespace: cellular_component def: "The specialized cell wall of the ascospore (spore), which is the product of meiotic division. Examples of this component are found in Fungi." [GOC:vw, ISBN:0879693568] synonym: "fungal-type spore wall" BROAD [GOC:mah] is_a: GO:0009277 ! fungal-type cell wall is_a: GO:0031160 ! spore wall property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005622 name: intracellular namespace: cellular_component def: "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "internal to cell" EXACT [] synonym: "nucleocytoplasm" RELATED [GOC:mah] synonym: "protoplasm" EXACT [] synonym: "protoplast" RELATED [GOC:mah] xref: Wikipedia:Intracellular is_a: GO:0044464 ! cell part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005623 name: cell namespace: cellular_component def: "The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:go_curators] subset: goslim_chembl subset: goslim_generic subset: goslim_plant subset: gosubset_prok xref: NIF_Subcellular:sao1813327414 xref: Wikipedia:Cell_(biology) is_a: GO:0005575 ! cellular_component property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl property_value: IAO:0000589 "cell and encapsulating structures" xsd:string [Term] id: GO:0005628 name: prospore membrane namespace: cellular_component def: "The prospore membrane is a double-membraned structure that extends from the cytoplasmic face of the spindle pole bodies to encompass the spindle pole bodies and the four nuclear lobes that are formed during meiosis. It helps isolate the meiotic nuclei from the cytoplasm during spore formation and serves as a foundation for the formation of the spore walls. An example of this component is found in Schizosaccharomyces pombe." [ISBN:0879693649] subset: gosubset_prok synonym: "ascospore-type prospore membrane" EXACT [GOC:mah] synonym: "forespore membrane" RELATED [] synonym: "FSM" EXACT [] is_a: GO:0016020 ! membrane is_a: GO:0044464 ! cell part relationship: part_of GO:0042764 ! ascospore-type prospore property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005634 name: nucleus namespace: cellular_component def: "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "cell nucleus" EXACT [] xref: NIF_Subcellular:sao1702920020 xref: Wikipedia:Cell_nucleus is_a: GO:0043231 ! intracellular membrane-bounded organelle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005635 name: nuclear envelope namespace: cellular_component alt_id: GO:0005636 def: "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684] subset: goslim_chembl subset: goslim_generic subset: goslim_plant xref: Wikipedia:Nuclear_envelope is_a: GO:0031967 ! organelle envelope is_a: GO:0044428 ! nuclear part relationship: part_of GO:0012505 ! endomembrane system property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005637 name: nuclear inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope." [GOC:ma] synonym: "inner envelope" BROAD [] synonym: "inner nuclear membrane" EXACT [GOC:kmv, GOC:vw, PMID:21411627] xref: NIF_Subcellular:sao1612527463 is_a: GO:0019866 ! organelle inner membrane is_a: GO:0031965 ! nuclear membrane property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005643 name: nuclear pore namespace: cellular_component alt_id: GO:0005644 def: "Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684] subset: goslim_pir synonym: "NPC" EXACT [] synonym: "nuclear pore complex" EXACT [] synonym: "nuclear pore membrane protein" NARROW [] synonym: "nucleopore" EXACT [GOC:al, PMID:7603572] xref: NIF_Subcellular:sao220861693 xref: Wikipedia:Nuclear_pore is_a: GO:0044428 ! nuclear part is_a: GO:0046930 ! pore complex relationship: part_of GO:0005635 ! nuclear envelope property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005654 name: nucleoplasm namespace: cellular_component def: "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] subset: goslim_chembl subset: goslim_generic subset: goslim_plant xref: NIF_Subcellular:sao661522542 xref: Wikipedia:Nucleoplasm is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031981 ! nuclear lumen property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005656 name: nuclear pre-replicative complex namespace: cellular_component def: "A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins." [PMID:15222894] synonym: "eukaryotic pre-replicative complex" EXACT [GOC:bf, GOC:bhm, GOC:jh2] synonym: "pre-RC" RELATED [] synonym: "pre-replicative complex" BROAD [GOC:bf, GOC:bhm, GOC:jh2] is_a: GO:0036387 ! pre-replicative complex is_a: GO:0044451 ! nucleoplasm part relationship: has_part GO:0000808 ! origin recognition complex relationship: has_part GO:0042555 ! MCM complex property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005657 name: replication fork namespace: cellular_component def: "The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684] subset: gosubset_prok synonym: "replication focus" RELATED [] xref: Wikipedia:Replication_fork is_a: GO:0044427 ! chromosomal part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005681 name: spliceosomal complex namespace: cellular_component def: "Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890] subset: goslim_pir synonym: "spliceosome" BROAD [] synonym: "spliceosome complex" EXACT [] xref: Wikipedia:Spliceosome is_a: GO:0030529 ! ribonucleoprotein complex is_a: GO:0044428 ! nuclear part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005682 name: U5 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U5." [GOC:krc, GOC:mah] synonym: "snRNP U5" EXACT [GOC:mah] is_a: GO:0097525 ! spliceosomal snRNP complex property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005684 name: U2-type spliceosomal complex namespace: cellular_component def: "Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends." [GOC:krc, GOC:mah, PMID:11343900] comment: A U2-type complex refers to any of the snRNP-based complexes that form during splicing that uses U2 (as opposed to U12). There are complexes that form during U2-splicing that don't necessarily contain the U2 snRNP. synonym: "GT-AG spliceosome" NARROW [GOC:krc, GOC:mah] synonym: "major (U2-type) spliceosomal complex" EXACT [GOC:krc, GOC:mah] synonym: "major spliceosomal complex" EXACT [GOC:krc, GOC:mah] is_a: GO:0005681 ! spliceosomal complex property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005686 name: U2 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U2." [GOC:krc, GOC:mah] comment: U2 snRNP refers to the U2 small nuclear RNA and the proteins that associate with it. U2 snRNP is not considered to be a type of spliceosomal complex by itself. synonym: "17S U2 snRNP" NARROW [] synonym: "snRNP U2" EXACT [GOC:mah] is_a: GO:0097525 ! spliceosomal snRNP complex property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005688 name: U6 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U6." [GOC:krc, GOC:mah] synonym: "snRNP U6" EXACT [GOC:mah] is_a: GO:0097525 ! spliceosomal snRNP complex property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005694 name: chromosome namespace: cellular_component def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "chromatid" RELATED [] synonym: "interphase chromosome" NARROW [] synonym: "prophase chromosome" NARROW [] xref: Wikipedia:Chromosome is_a: GO:0043232 ! intracellular non-membrane-bounded organelle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005720 name: nuclear heterochromatin namespace: cellular_component def: "A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin." [ISBN:0198506732] is_a: GO:0000790 ! nuclear chromatin is_a: GO:0000792 ! heterochromatin intersection_of: GO:0000792 ! heterochromatin intersection_of: part_of GO:0000228 ! nuclear chromosome relationship: part_of GO:0000228 ! nuclear chromosome property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005721 name: pericentric heterochromatin namespace: cellular_component def: "Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3." [PMID:12019236, PMID:20206496, PMID:22729156] synonym: "centric heterochromatin" EXACT [] synonym: "centromeric heterochromatin" EXACT [GOC:dph] is_a: GO:0000792 ! heterochromatin intersection_of: GO:0000792 ! heterochromatin intersection_of: part_of GO:0000775 ! chromosome, centromeric region relationship: part_of GO:0000775 ! chromosome, centromeric region property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005730 name: nucleolus namespace: cellular_component def: "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: NIF_Subcellular:sao1820400233 xref: Wikipedia:Nucleolus is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031981 ! nuclear lumen property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005737 name: cytoplasm namespace: cellular_component def: "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: Wikipedia:Cytoplasm is_a: GO:0044424 ! intracellular part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005739 name: mitochondrion namespace: cellular_component def: "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] comment: Some anaerobic or microaerophilic organisms (e.g. Entamoeba histolytica, Giardia intestinalis and several Microsporidia species) do not have mitochondria, and contain mitochondrion-related organelles (MROs) instead, called mitosomes or hydrogenosomes, very likely derived from mitochondria. To annotate gene products located in these mitochondrial relics in species such as Entamoeba histolytica, Giardia intestinalis or others, please use GO:0032047 'mitosome' or GO:0042566 'hydrogenosome'. (See PMID:24316280 for a list of species currently known to contain mitochondrion-related organelles.) subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "mitochondria" EXACT [] xref: NIF_Subcellular:sao1860313010 xref: Wikipedia:Mitochondrion is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005740 name: mitochondrial envelope namespace: cellular_component def: "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz] subset: goslim_candida subset: goslim_yeast is_a: GO:0031967 ! organelle envelope is_a: GO:0044429 ! mitochondrial part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005743 name: mitochondrial inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] synonym: "inner mitochondrial membrane" EXACT [] xref: NIF_Subcellular:sao1371347282 xref: Wikipedia:Inner_mitochondrial_membrane is_a: GO:0019866 ! organelle inner membrane is_a: GO:0031966 ! mitochondrial membrane property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005746 name: mitochondrial respiratory chain namespace: cellular_component def: "The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:curators, GOC:ecd, ISBN:0198547684] synonym: "mitochondrial electron transport chain" EXACT [] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0070469 ! respiratory chain intersection_of: GO:0070469 ! respiratory chain intersection_of: part_of GO:0005743 ! mitochondrial inner membrane relationship: part_of GO:0005743 ! mitochondrial inner membrane property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005751 name: mitochondrial respiratory chain complex IV namespace: cellular_component alt_id: GO:0005752 def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [GOC:mtg_sensu, ISBN:0198547684] is_a: GO:0045277 ! respiratory chain complex IV is_a: GO:0098800 ! inner mitochondrial membrane protein complex intersection_of: GO:0045277 ! respiratory chain complex IV intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005746 ! mitochondrial respiratory chain property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005759 name: mitochondrial matrix namespace: cellular_component alt_id: GO:0031980 def: "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] synonym: "mitochondrial lumen" EXACT [] synonym: "mitochondrial stroma" NARROW [] xref: NIF_Subcellular:sao-1899375636 xref: NIF_Subcellular:sao1804523077 xref: Wikipedia:Mitochondrial_matrix is_a: GO:0044429 ! mitochondrial part is_a: GO:0070013 ! intracellular organelle lumen property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005773 name: vacuole namespace: cellular_component def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "vacuolar carboxypeptidase Y" RELATED [] xref: Wikipedia:Vacuole is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005776 name: autophagosome namespace: cellular_component def: "A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the vacuole/lysosome for degradation as part of macroautophagy." [GOC:autophagy, ISBN:0198547684, PMID:11099404] synonym: "autophagic vacuole" EXACT [NIF_Subcellular:sao8663416959] synonym: "initial autophagic vacuole" RELATED [NIF_Subcellular:sao8663416959] xref: NIF_Subcellular:sao8663416959 is_a: GO:0005773 ! vacuole property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005777 name: peroxisome namespace: cellular_component alt_id: GO:0019818 def: "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_plant subset: goslim_yeast synonym: "peroxisomal" RELATED [GOC:curators] synonym: "peroxisome vesicle" BROAD [] xref: NIF_Subcellular:sao499555322 xref: Wikipedia:Peroxisome is_a: GO:0042579 ! microbody property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005783 name: endoplasmic reticulum namespace: cellular_component def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "ER" EXACT [] xref: NIF_Subcellular:sao1036339110 xref: Wikipedia:Endoplasmic_reticulum is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0012505 ! endomembrane system property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005789 name: endoplasmic reticulum membrane namespace: cellular_component def: "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] synonym: "ER membrane" EXACT [] is_a: GO:0044425 ! membrane part is_a: GO:0044432 ! endoplasmic reticulum part is_a: GO:0098588 ! bounding membrane of organelle relationship: part_of GO:0042175 ! nuclear outer membrane-endoplasmic reticulum membrane network property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005794 name: Golgi apparatus namespace: cellular_component def: "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "Golgi" BROAD [] synonym: "Golgi complex" EXACT [] synonym: "Golgi ribbon" NARROW [] xref: NIF_Subcellular:sao451912436 xref: Wikipedia:Golgi_apparatus is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0012505 ! endomembrane system property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005795 name: Golgi stack namespace: cellular_component alt_id: GO:0016940 def: "The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194] synonym: "dictyosome" NARROW [] synonym: "Golgi cisternae" EXACT [] is_a: GO:0098791 ! Golgi subcompartment relationship: part_of GO:0005794 ! Golgi apparatus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005811 name: lipid particle namespace: cellular_component def: "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] comment: Note that this term does not refer to vesicles, but instead to structures in which lipids do not necessarily form bilayers. subset: goslim_chembl subset: goslim_generic synonym: "adiposome" EXACT [] synonym: "lipid body" EXACT [] synonym: "lipid droplet" EXACT [] is_a: GO:0043232 ! intracellular non-membrane-bounded organelle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005815 name: microtubule organizing center namespace: cellular_component def: "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, http://en.wikipedia.org/wiki/Microtubule_organizing_center, ISBN:0815316194, PMID:17072892, PMID:17245416] subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "microtubule organising centre" EXACT [] synonym: "MTOC" EXACT [] xref: Wikipedia:Microtubule_organizing_center is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015630 ! microtubule cytoskeleton property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005816 name: spindle pole body namespace: cellular_component def: "The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome." [ISBN:0879693568] synonym: "SPB" EXACT [GOC:mah] xref: Wikipedia:Spindle_pole_body is_a: GO:0005815 ! microtubule organizing center relationship: part_of GO:0000922 ! spindle pole property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005818 name: aster namespace: cellular_component def: "An array of microtubules emanating from a spindle pole MTOC that do not connect to kinetochores." [GOC:clt] is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0043234 ! protein complex is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0005819 ! spindle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005819 name: spindle namespace: cellular_component def: "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] xref: Wikipedia:Spindle_apparatus is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015630 ! microtubule cytoskeleton property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005826 name: actomyosin contractile ring namespace: cellular_component alt_id: GO:0030480 def: "A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells. In animal cells, the contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms beneath the plasma membrane at the mother-bud neck before mitosis." [GOC:expert_jrp, GOC:sgd_curators, ISBN:0805319409, ISBN:0815316194] synonym: "actomyosin ring" RELATED [] synonym: "CAR" EXACT [] synonym: "constriction ring" RELATED [] synonym: "contractile actomyosin ring" EXACT [] synonym: "cytokinetic ring" RELATED [] is_a: GO:0032155 ! cell division site part is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044448 ! cell cortex part is_a: GO:0070938 ! contractile ring relationship: part_of GO:0030864 ! cortical actin cytoskeleton property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005827 name: polar microtubule namespace: cellular_component def: "Any of the spindle microtubules that come from each pole and overlap at the spindle midzone. This interdigitating structure consisting of antiparallel microtubules is responsible for pushing the poles of the spindle apart." [ISBN:0815316194] synonym: "pole-to-pole microtubule" EXACT [] is_a: GO:0005876 ! spindle microtubule intersection_of: GO:0005876 ! spindle microtubule intersection_of: part_of GO:0000922 ! spindle pole relationship: part_of GO:0000922 ! spindle pole property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005829 name: cytosol namespace: cellular_component def: "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hgd, GOC:jl] subset: goslim_aspergillus subset: goslim_chembl subset: goslim_generic subset: goslim_plant subset: gosubset_prok xref: NIF_Subcellular:sao101633890 xref: Wikipedia:Cytosol is_a: GO:0044444 ! cytoplasmic part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005840 name: ribosome namespace: cellular_component alt_id: GO:0033279 def: "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "free ribosome" NARROW [NIF_Subcellular:sao1139385046] synonym: "membrane bound ribosome" NARROW [NIF_Subcellular:sao1291545653] synonym: "ribosomal RNA" RELATED [] xref: NIF_Subcellular:sao1429207766 xref: Wikipedia:Ribosome is_a: GO:0030529 ! ribonucleoprotein complex is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005856 name: cytoskeleton namespace: cellular_component def: "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: Wikipedia:Cytoskeleton is_a: GO:0043232 ! intracellular non-membrane-bounded organelle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005874 name: microtubule namespace: cellular_component def: "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] synonym: "microtubuli" EXACT [] synonym: "microtubulus" EXACT [] synonym: "neurotubule" NARROW [NIF_Subcellular:sao248349196] xref: NIF_Subcellular:sao1846835077 xref: Wikipedia:Microtubule is_a: GO:0043234 ! protein complex is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015630 ! microtubule cytoskeleton property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005876 name: spindle microtubule namespace: cellular_component def: "Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194] is_a: GO:0005874 ! microtubule intersection_of: GO:0005874 ! microtubule intersection_of: part_of GO:0005819 ! spindle relationship: part_of GO:0005819 ! spindle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005880 name: nuclear microtubule namespace: cellular_component def: "Any microtubule in the nucleus of a cell." [GOC:mah] is_a: GO:0005874 ! microtubule is_a: GO:0044428 ! nuclear part intersection_of: GO:0005874 ! microtubule intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0005634 ! nucleus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005881 name: cytoplasmic microtubule namespace: cellular_component def: "Any microtubule in the cytoplasm of a cell." [GOC:mah] synonym: "non-spindle-associated astral microtubule" NARROW [] is_a: GO:0005874 ! microtubule is_a: GO:0044444 ! cytoplasmic part intersection_of: GO:0005874 ! microtubule intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005737 ! cytoplasm property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005884 name: actin filament namespace: cellular_component def: "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339] synonym: "microfilament" EXACT [] xref: FMA:63850 xref: NIF_Subcellular:sao1588493326 xref: Wikipedia:Actin is_a: GO:0043234 ! protein complex is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015629 ! actin cytoskeleton property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005886 name: plasma membrane namespace: cellular_component alt_id: GO:0005904 def: "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "bacterial inner membrane" NARROW [] synonym: "cell membrane" EXACT [] synonym: "cellular membrane" EXACT [NIF_Subcellular:sao6433132645] synonym: "cytoplasmic membrane" EXACT [] synonym: "inner endospore membrane" NARROW [] synonym: "juxtamembrane" BROAD [] synonym: "plasma membrane lipid bilayer" NARROW [GOC:mah] synonym: "plasmalemma" EXACT [] xref: NIF_Subcellular:sao1663586795 xref: Wikipedia:Cell_membrane is_a: GO:0016020 ! membrane is_a: GO:0044464 ! cell part relationship: part_of GO:0071944 ! cell periphery property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005937 name: mating projection namespace: cellular_component def: "The projection formed by unicellular fungi in response to mating pheromone." [GOC:mcc] subset: goslim_pir synonym: "conjugation tube" NARROW [] synonym: "shmoo" NARROW [] is_a: GO:0042995 ! cell projection property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005938 name: cell cortex namespace: cellular_component def: "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] subset: goslim_aspergillus subset: goslim_candida subset: goslim_yeast synonym: "cell periphery" RELATED [] synonym: "peripheral cytoplasm" RELATED [] xref: Wikipedia:Cell_cortex is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0071944 ! cell periphery property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005975 name: carbohydrate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "carbohydrate metabolism" EXACT [] xref: Reactome:REACT_102834 "Metabolism of carbohydrates, Mus musculus" xref: Reactome:REACT_103806 "Metabolism of carbohydrates, Mycobacterium tuberculosis" xref: Reactome:REACT_104502 "Metabolism of carbohydrates, Gallus gallus" xref: Reactome:REACT_105321 "Metabolism of carbohydrates, Escherichia coli" xref: Reactome:REACT_106046 "Metabolism of carbohydrates, Drosophila melanogaster" xref: Reactome:REACT_107409 "Metabolism of carbohydrates, Caenorhabditis elegans" xref: Reactome:REACT_115733 "Carbohydrate metabolism, Gallus gallus" xref: Reactome:REACT_28218 "Metabolism of carbohydrates, Xenopus tropicalis" xref: Reactome:REACT_32291 "Metabolism of carbohydrates, Staphylococcus aureus N315" xref: Reactome:REACT_33141 "Metabolism of carbohydrates, Taeniopygia guttata" xref: Reactome:REACT_33953 "Metabolism of carbohydrates, Rattus norvegicus" xref: Reactome:REACT_34800 "Metabolism of carbohydrates, Danio rerio" xref: Reactome:REACT_474 "Metabolism of carbohydrates, Homo sapiens" xref: Reactome:REACT_77669 "Metabolism of carbohydrates, Plasmodium falciparum" xref: Reactome:REACT_81945 "Metabolism of carbohydrates, Schizosaccharomyces pombe" xref: Reactome:REACT_83038 "Metabolism of carbohydrates, Arabidopsis thaliana" xref: Reactome:REACT_83329 "Metabolism of carbohydrates, Saccharomyces cerevisiae" xref: Reactome:REACT_88330 "Metabolism of carbohydrates, Bos taurus" xref: Reactome:REACT_88558 "Metabolism of carbohydrates, Canis familiaris" xref: Reactome:REACT_90099 "Metabolism of carbohydrates, Sus scrofa" xref: Reactome:REACT_96375 "Metabolism of carbohydrates, Dictyostelium discoideum" xref: Reactome:REACT_98394 "Metabolism of carbohydrates, Oryza sativa" xref: Wikipedia:Carbohydrate_metabolism is_a: GO:0044238 ! primary metabolic process is_a: GO:0071704 ! organic substance metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005976 name: polysaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, ISBN:0198547684] subset: goslim_pir subset: gosubset_prok synonym: "glycan metabolic process" EXACT [] synonym: "glycan metabolism" EXACT [] synonym: "polysaccharide metabolism" EXACT [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0043170 ! macromolecule metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0005984 name: disaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any disaccharide, sugars composed of two monosaccharide units." [GOC:jl, ISBN:01928006X] subset: gosubset_prok synonym: "disaccharide metabolism" EXACT [] is_a: GO:0009311 ! oligosaccharide metabolic process is_a: GO:0044262 ! cellular carbohydrate metabolic process is_a: GO:0044763 ! single-organism cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006066 name: alcohol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732] subset: goslim_pir subset: gosubset_prok synonym: "alcohol metabolism" EXACT [] is_a: GO:0044281 ! small molecule metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006073 name: cellular glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues." [ISBN:0198547684] subset: gosubset_prok synonym: "cellular glucan metabolism" EXACT [] is_a: GO:0044042 ! glucan metabolic process is_a: GO:0044264 ! cellular polysaccharide metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006081 name: cellular aldehyde metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells." [GOC:go_curators, ISBN:0198506732] subset: goslim_pir subset: gosubset_prok synonym: "aldehyde metabolism" EXACT [] synonym: "alkanal metabolic process" EXACT [] synonym: "alkanal metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process is_a: GO:0044710 ! single-organism metabolic process is_a: GO:0044763 ! single-organism cellular process is_a: GO:0071704 ! organic substance metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006082 name: organic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] subset: goslim_pir subset: gosubset_prok synonym: "organic acid metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0044763 ! single-organism cellular process is_a: GO:0071704 ! organic substance metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006089 name: lactate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lactate, the anion of lactic acid." [ISBN:0198547684] subset: gosubset_prok synonym: "2-hydroxypropanoate metabolic process" EXACT [] synonym: "2-hydroxypropanoate metabolism" EXACT [] synonym: "alpha-hydroxypropionate metabolic process" EXACT [] synonym: "alpha-hydroxypropionate metabolism" EXACT [] synonym: "lactate metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006091 name: generation of precursor metabolites and energy namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl] subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "energy pathways" BROAD [] synonym: "intermediary metabolism" RELATED [GOC:mah] synonym: "metabolic energy generation" RELATED [] is_a: GO:0044237 ! cellular metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006113 name: fermentation namespace: biological_process def: "The anaerobic enzymatic conversion of organic compounds, especially carbohydrates, coupling the oxidation and reduction of NAD/H and the generation of adenosine triphosphate (ATP)." [GOC:curators, ISBN:0201090910, ISBN:124925502, MetaCyc:Fermentation] subset: goslim_pir subset: gosubset_prok xref: MetaCyc:FERMENTATION-PWY xref: Wikipedia:Fermentation_(biochemistry) is_a: GO:0015980 ! energy derivation by oxidation of organic compounds property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006119 name: oxidative phosphorylation namespace: biological_process def: "The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [ISBN:0198506732, ISBN:0471331309] subset: goslim_pir subset: gosubset_prok synonym: "respiratory-chain phosphorylation" EXACT [] xref: Wikipedia:Oxidative_phosphorylation is_a: GO:0006091 ! generation of precursor metabolites and energy is_a: GO:0016310 ! phosphorylation is_a: GO:0046034 ! ATP metabolic process relationship: has_part GO:0015986 ! ATP synthesis coupled proton transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006120 name: mitochondrial electron transport, NADH to ubiquinone namespace: biological_process def: "The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I." [ISBN:0716731363] synonym: "complex I (NADH to ubiquinone)" RELATED [] synonym: "oxidative phosphorylation, NADH to ubiquinone" EXACT [] xref: Reactome:REACT_102400 "NADH enters the respiratory chain at Complex I, Gallus gallus" xref: Reactome:REACT_33391 "NADH enters the respiratory chain at Complex I, Rattus norvegicus" xref: Reactome:REACT_6310 "NADH enters the respiratory chain at Complex I, Homo sapiens" xref: Reactome:REACT_81770 "NADH enters the respiratory chain at Complex I, Canis familiaris" xref: Reactome:REACT_81943 "NADH enters the respiratory chain at Complex I, Mus musculus" xref: Reactome:REACT_84378 "NADH enters the respiratory chain at Complex I, Bos taurus" xref: Reactome:REACT_86959 "NADH enters the respiratory chain at Complex I, Danio rerio" xref: Reactome:REACT_96903 "NADH enters the respiratory chain at Complex I, Sus scrofa" xref: Reactome:REACT_98202 "NADH enters the respiratory chain at Complex I, Drosophila melanogaster" is_a: GO:0022904 ! respiratory electron transport chain relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006121 name: mitochondrial electron transport, succinate to ubiquinone namespace: biological_process def: "The transfer of electrons from succinate to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex II." [ISBN:0716731363] synonym: "complex II (succinate to ubiquinone)" RELATED [] synonym: "mitochondrial electron transport, succinate to coenzyme Q" EXACT [] synonym: "oxidative phosphorylation, succinate to ubiquinone" EXACT [] xref: Reactome:REACT_103505 "Transfer of electrons through the succinate dehydrogenase complex, Danio rerio" xref: Reactome:REACT_6292 "Transfer of electrons through the bovine succinate dehydrogenase complex, Bos taurus" xref: Reactome:REACT_6360 "Transfer of electrons through the succinate dehydrogenase complex, Homo sapiens" xref: Reactome:REACT_80248 "Transfer of electrons through the succinate dehydrogenase complex, Schizosaccharomyces pombe" xref: Reactome:REACT_83108 "Transfer of electrons through the succinate dehydrogenase complex, Caenorhabditis elegans" xref: Reactome:REACT_84221 "Transfer of electrons through the succinate dehydrogenase complex, Canis familiaris" xref: Reactome:REACT_88562 "Transfer of electrons through the succinate dehydrogenase complex, Saccharomyces cerevisiae" xref: Reactome:REACT_88611 "Transfer of electrons through the succinate dehydrogenase complex, Drosophila melanogaster" xref: Reactome:REACT_90176 "Transfer of electrons through the succinate dehydrogenase complex, Taeniopygia guttata" xref: Reactome:REACT_92395 "Transfer of electrons through the succinate dehydrogenase complex, Mus musculus" xref: Reactome:REACT_92514 "Transfer of electrons through the succinate dehydrogenase complex, Xenopus tropicalis" xref: Reactome:REACT_97027 "Transfer of electrons through the succinate dehydrogenase complex, Rattus norvegicus" xref: Reactome:REACT_98347 "Transfer of electrons through the succinate dehydrogenase complex, Gallus gallus" xref: Reactome:REACT_99727 "Transfer of electrons through the succinate dehydrogenase complex, Dictyostelium discoideum" is_a: GO:0022904 ! respiratory electron transport chain relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006139 name: nucleobase-containing compound metabolic process namespace: biological_process alt_id: GO:0055134 def: "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] synonym: "nucleobase, nucleoside and nucleotide metabolic process" RELATED [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0044238 ! primary metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006163 name: purine nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "purine metabolic process" NARROW [] synonym: "purine metabolism" NARROW [] synonym: "purine nucleotide metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0072521 ! purine-containing compound metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006164 name: purine nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "purine nucleotide anabolism" EXACT [] synonym: "purine nucleotide biosynthesis" EXACT [] synonym: "purine nucleotide formation" EXACT [] synonym: "purine nucleotide synthesis" EXACT [] xref: MetaCyc:DENOVOPURINE2-PWY is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0072522 ! purine-containing compound biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006165 name: nucleoside diphosphate phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate." [GOC:ai] subset: gosubset_prok is_a: GO:0009132 ! nucleoside diphosphate metabolic process is_a: GO:0046939 ! nucleotide phosphorylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006171 name: cAMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732] subset: gosubset_prok synonym: "3',5' cAMP biosynthesis" EXACT [] synonym: "3',5' cAMP biosynthetic process" EXACT [] synonym: "3',5'-cAMP biosynthesis" EXACT [] synonym: "3',5'-cAMP biosynthetic process" EXACT [] synonym: "adenosine 3',5'-cyclophosphate biosynthesis" EXACT [] synonym: "adenosine 3',5'-cyclophosphate biosynthetic process" EXACT [] synonym: "cAMP anabolism" EXACT [] synonym: "cAMP biosynthesis" EXACT [] synonym: "cAMP formation" EXACT [] synonym: "cAMP synthesis" EXACT [] synonym: "cyclic AMP biosynthesis" EXACT [] synonym: "cyclic AMP biosynthetic process" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0046058 ! cAMP metabolic process is_a: GO:0052652 ! cyclic purine nucleotide metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006220 name: pyrimidine nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "pyrimidine metabolic process" BROAD [] synonym: "pyrimidine metabolism" BROAD [] synonym: "pyrimidine nucleotide metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0072527 ! pyrimidine-containing compound metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006221 name: pyrimidine nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "pyrimidine nucleotide anabolism" EXACT [] synonym: "pyrimidine nucleotide biosynthesis" EXACT [] synonym: "pyrimidine nucleotide formation" EXACT [] synonym: "pyrimidine nucleotide synthesis" EXACT [] is_a: GO:0006220 ! pyrimidine nucleotide metabolic process is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0072528 ! pyrimidine-containing compound biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006235 name: dTTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate." [ISBN:0198506732] subset: gosubset_prok synonym: "dTTP anabolism" EXACT [] synonym: "dTTP biosynthesis" EXACT [] synonym: "dTTP formation" EXACT [] synonym: "dTTP synthesis" EXACT [] is_a: GO:0009212 ! pyrimidine deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process is_a: GO:0046075 ! dTTP metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006259 name: DNA metabolic process namespace: biological_process alt_id: GO:0055132 def: "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "cellular DNA metabolism" EXACT [] synonym: "DNA metabolism" EXACT [] is_a: GO:0044260 ! cellular macromolecule metabolic process is_a: GO:0090304 ! nucleic acid metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006260 name: DNA replication namespace: biological_process alt_id: GO:0055133 def: "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] comment: See also the biological process terms 'DNA-dependent DNA replication ; GO:0006261' and 'RNA-dependent DNA replication ; GO:0006278'. subset: goslim_pir subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok xref: Reactome:REACT_100559 "Activation of ATR in response to replication stress, Mus musculus" xref: Reactome:REACT_101280 "Activation of claspin, Xenopus tropicalis" xref: Reactome:REACT_101497 "Activation of claspin, Bos taurus" xref: Reactome:REACT_102679 "Activation of ATR in response to replication stress, Gallus gallus" xref: Reactome:REACT_103614 "Stalling of DNA replication fork and RPA binding, Taeniopygia guttata" xref: Reactome:REACT_104547 "Recruitment and activation of Chk1, Gallus gallus" xref: Reactome:REACT_105292 "Activation of ATR in response to replication stress, Xenopus tropicalis" xref: Reactome:REACT_105467 "Loading of claspin onto DNA during replication origin firing, Danio rerio" xref: Reactome:REACT_105835 "Stalling of DNA replication fork and RPA binding, Gallus gallus" xref: Reactome:REACT_106018 "Recruitment of Rad17-RFC complex to DNA, Gallus gallus" xref: Reactome:REACT_106104 "Binding of ATR-ATRIP to the RPA-ssDNA complex, Bos taurus" xref: Reactome:REACT_106382 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Drosophila melanogaster" xref: Reactome:REACT_106434 "Activation of claspin, Canis familiaris" xref: Reactome:REACT_106732 "Recruitment and activation of Chk1, Canis familiaris" xref: Reactome:REACT_107075 "Activation of ATR in response to replication stress, Danio rerio" xref: Reactome:REACT_107423 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Caenorhabditis elegans" xref: Reactome:REACT_108461 "Recruitment and activation of Chk1, Bos taurus" xref: Reactome:REACT_108634 "Loading of claspin onto DNA during replication origin firing, Mus musculus" xref: Reactome:REACT_108739 "Binding of ATR-ATRIP to the RPA-ssDNA complex, Xenopus tropicalis" xref: Reactome:REACT_108768 "Activation of ATR in response to replication stress, Bos taurus" xref: Reactome:REACT_108929 "Activation of ATR in response to replication stress, Drosophila melanogaster" xref: Reactome:REACT_109137 "Stalling of DNA replication fork and RPA binding, Rattus norvegicus" xref: Reactome:REACT_112472 "Activation of ATR in response to replication stress, Saccharomyces cerevisiae" xref: Reactome:REACT_113703 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Gallus gallus" xref: Reactome:REACT_29423 "Activation of ATR in response to replication stress, Schizosaccharomyces pombe" xref: Reactome:REACT_29444 "Binding of ATR-ATRIP to the RPA-ssDNA complex, Taeniopygia guttata" xref: Reactome:REACT_29691 "Activation of ATR in response to replication stress, Rattus norvegicus" xref: Reactome:REACT_29764 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Taeniopygia guttata" xref: Reactome:REACT_30149 "Activation of claspin, Rattus norvegicus" xref: Reactome:REACT_31024 "Recruitment of Rad17-RFC complex to DNA, Xenopus tropicalis" xref: Reactome:REACT_31919 "Loading of claspin onto DNA during replication origin firing, Rattus norvegicus" xref: Reactome:REACT_32546 "Recruitment of Rad17-RFC complex to DNA, Mus musculus" xref: Reactome:REACT_32932 "Recruitment and activation of Chk1, Taeniopygia guttata" xref: Reactome:REACT_33572 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Dictyostelium discoideum" xref: Reactome:REACT_33874 "Recruitment and activation of Chk1, Xenopus tropicalis" xref: Reactome:REACT_50018 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Rattus norvegicus" xref: Reactome:REACT_53588 "Loading of claspin onto DNA during replication origin firing, Canis familiaris" xref: Reactome:REACT_6729 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Homo sapiens" xref: Reactome:REACT_6738 "Loading of claspin onto DNA during replication origin firing, Homo sapiens" xref: Reactome:REACT_6750 "Activation of claspin, Homo sapiens" xref: Reactome:REACT_6769 "Activation of ATR in response to replication stress, Homo sapiens" xref: Reactome:REACT_6798 "Recruitment of Rad17-RFC complex to DNA, Homo sapiens" xref: Reactome:REACT_6869 "Recruitment and activation of Chk1, Homo sapiens" xref: Reactome:REACT_6936 "Stalling of DNA replication fork and RPA binding, Homo sapiens" xref: Reactome:REACT_6939 "Binding of ATR-ATRIP to the RPA-ssDNA complex, Homo sapiens" xref: Reactome:REACT_77532 "Stalling of DNA replication fork and RPA binding, Canis familiaris" xref: Reactome:REACT_79188 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Canis familiaris" xref: Reactome:REACT_79450 "Activation of ATR in response to replication stress, Dictyostelium discoideum" xref: Reactome:REACT_80432 "Loading of claspin onto DNA during replication origin firing, Taeniopygia guttata" xref: Reactome:REACT_80571 "Activation of claspin, Mus musculus" xref: Reactome:REACT_80896 "Recruitment and activation of Chk1, Sus scrofa" xref: Reactome:REACT_80988 "Loading of claspin onto DNA during replication origin firing, Bos taurus" xref: Reactome:REACT_81803 "Recruitment of Rad17-RFC complex to DNA, Canis familiaris" xref: Reactome:REACT_83095 "Recruitment of Rad17-RFC complex to DNA, Danio rerio" xref: Reactome:REACT_84829 "Binding of ATR-ATRIP to the RPA-ssDNA complex, Danio rerio" xref: Reactome:REACT_85561 "Binding of ATR-ATRIP to the RPA-ssDNA complex, Rattus norvegicus" xref: Reactome:REACT_86410 "Stalling of DNA replication fork and RPA binding, Mus musculus" xref: Reactome:REACT_86739 "Recruitment and activation of Chk1, Rattus norvegicus" xref: Reactome:REACT_87233 "Binding of ATR-ATRIP to the RPA-ssDNA complex, Canis familiaris" xref: Reactome:REACT_87449 "Recruitment of Rad17-RFC complex to DNA, Rattus norvegicus" xref: Reactome:REACT_87590 "Recruitment of Rad17-RFC complex to DNA, Bos taurus" xref: Reactome:REACT_88085 "Binding of ATR-ATRIP to the RPA-ssDNA complex, Gallus gallus" xref: Reactome:REACT_88384 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Schizosaccharomyces pombe" xref: Reactome:REACT_88529 "Activation of claspin, Gallus gallus" xref: Reactome:REACT_89355 "Activation of claspin, Danio rerio" xref: Reactome:REACT_89439 "Activation of ATR in response to replication stress, Sus scrofa" xref: Reactome:REACT_89725 "Loading of claspin onto DNA during replication origin firing, Drosophila melanogaster" xref: Reactome:REACT_90512 "Stalling of DNA replication fork and RPA binding, Bos taurus" xref: Reactome:REACT_90809 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Danio rerio" xref: Reactome:REACT_90838 "Recruitment of Rad17-RFC complex to DNA, Taeniopygia guttata" xref: Reactome:REACT_91184 "Recruitment and activation of Chk1, Danio rerio" xref: Reactome:REACT_91302 "Activation of ATR in response to replication stress, Canis familiaris" xref: Reactome:REACT_92527 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Mus musculus" xref: Reactome:REACT_92644 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Xenopus tropicalis" xref: Reactome:REACT_92706 "Stalling of DNA replication fork and RPA binding, Danio rerio" xref: Reactome:REACT_94983 "Stalling of DNA replication fork and RPA binding, Xenopus tropicalis" xref: Reactome:REACT_95253 "Activation of ATR in response to replication stress, Taeniopygia guttata" xref: Reactome:REACT_95329 "Activation of claspin, Taeniopygia guttata" xref: Reactome:REACT_96115 "Binding of ATR-ATRIP to the RPA-ssDNA complex, Mus musculus" xref: Reactome:REACT_96804 "Recruitment and activation of Chk1, Mus musculus" xref: Reactome:REACT_96998 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA, Bos taurus" xref: Reactome:REACT_97204 "Loading of claspin onto DNA during replication origin firing, Gallus gallus" xref: Reactome:REACT_97726 "Activation of ATR in response to replication stress, Caenorhabditis elegans" xref: Reactome:REACT_99948 "Loading of claspin onto DNA during replication origin firing, Xenopus tropicalis" xref: Wikipedia:DNA_replication is_a: GO:0006259 ! DNA metabolic process is_a: GO:0034645 ! cellular macromolecule biosynthetic process relationship: has_part GO:0071897 ! DNA biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006261 name: DNA-dependent DNA replication namespace: biological_process alt_id: GO:0006262 alt_id: GO:0006263 def: "A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732] subset: gosubset_prok is_a: GO:0006260 ! DNA replication property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006267 name: pre-replicative complex assembly involved in nuclear cell cycle DNA replication namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the nuclear pre-replicative complex, a protein-DNA complex that forms at the eukaryotic DNA replication origin and is required for replication initiation." [GOC:mtg_cell_cycle] synonym: "nuclear pre-replicative complex assembly" EXACT [] synonym: "pre-RC complex assembly" BROAD [] synonym: "pre-replicative complex assembly" BROAD [GOC:bf, GOC:bhm, GOC:jh2] synonym: "pre-replicative complex formation" BROAD [] is_a: GO:1902299 ! pre-replicative complex assembly involved in cell cycle DNA replication relationship: part_of GO:0033260 ! nuclear DNA replication property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006269 name: DNA replication, synthesis of RNA primer namespace: biological_process def: "The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA as a template; the RNA then serves as a primer from which DNA polymerases extend synthesis." [PMID:11395402] subset: gosubset_prok synonym: "replication priming" RELATED [] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0032774 ! RNA biosynthetic process relationship: part_of GO:0006261 ! DNA-dependent DNA replication property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006270 name: DNA replication initiation namespace: biological_process alt_id: GO:0042024 def: "The process in which DNA-dependent DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action." [ISBN:071673706X, ISBN:0815316194] subset: gosubset_prok synonym: "DNA endoreduplication initiation" NARROW [] synonym: "DNA re-replication initiation" NARROW [] synonym: "DNA-dependent DNA replication initiation" EXACT [GOC:vw] xref: Reactome:REACT_102345 "DNA replication initiation, Plasmodium falciparum" xref: Reactome:REACT_104509 "DNA replication initiation, Caenorhabditis elegans" xref: Reactome:REACT_2244 "DNA replication initiation, Homo sapiens" xref: Reactome:REACT_29293 "DNA replication initiation, Bos taurus" xref: Reactome:REACT_30671 "DNA replication initiation, Arabidopsis thaliana" xref: Reactome:REACT_31785 "DNA replication initiation, Xenopus tropicalis" xref: Reactome:REACT_51432 "DNA replication initiation, Mus musculus" xref: Reactome:REACT_77017 "DNA replication initiation, Sus scrofa" xref: Reactome:REACT_80370 "DNA replication initiation, Dictyostelium discoideum" xref: Reactome:REACT_89418 "DNA replication initiation, Saccharomyces cerevisiae" xref: Reactome:REACT_89696 "DNA replication initiation, Danio rerio" xref: Reactome:REACT_94747 "DNA replication initiation, Schizosaccharomyces pombe" xref: Reactome:REACT_95351 "DNA replication initiation, Oryza sativa" xref: Reactome:REACT_96273 "DNA replication initiation, Canis familiaris" xref: Reactome:REACT_97560 "DNA replication initiation, Drosophila melanogaster" xref: Reactome:REACT_97787 "DNA replication initiation, Rattus norvegicus" is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006261 ! DNA-dependent DNA replication property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006271 name: DNA strand elongation involved in DNA replication namespace: biological_process def: "The process in which a DNA strand is synthesized from template DNA during replication by the action of polymerases, which add nucleotides to the 3' end of the nascent DNA strand." [ISBN:071673706X, ISBN:0815316194] subset: gosubset_prok synonym: "DNA replication elongation" EXACT [] synonym: "DNA strand elongation during DNA replication" RELATED [GOC:dph, GOC:tb] xref: Reactome:REACT_100837 "DNA strand elongation, Schizosaccharomyces pombe" xref: Reactome:REACT_102588 "DNA strand elongation, Canis familiaris" xref: Reactome:REACT_103840 "DNA strand elongation, Danio rerio" xref: Reactome:REACT_104474 "DNA strand elongation, Mus musculus" xref: Reactome:REACT_107311 "DNA strand elongation, Saccharomyces cerevisiae" xref: Reactome:REACT_30657 "DNA strand elongation, Rattus norvegicus" xref: Reactome:REACT_76948 "DNA strand elongation, Plasmodium falciparum" xref: Reactome:REACT_83094 "DNA strand elongation, Caenorhabditis elegans" xref: Reactome:REACT_83610 "DNA strand elongation, Dictyostelium discoideum" xref: Reactome:REACT_84115 "DNA strand elongation, Oryza sativa" xref: Reactome:REACT_84140 "DNA strand elongation, Drosophila melanogaster" xref: Reactome:REACT_85176 "DNA strand elongation, Mycobacterium tuberculosis" xref: Reactome:REACT_85667 "DNA strand elongation, Arabidopsis thaliana" xref: Reactome:REACT_88125 "DNA strand elongation, Bos taurus" xref: Reactome:REACT_92780 "DNA strand elongation, Gallus gallus" xref: Reactome:REACT_932 "DNA strand elongation, Homo sapiens" xref: Reactome:REACT_95055 "DNA strand elongation, Sus scrofa" xref: Reactome:REACT_99290 "DNA strand elongation, Xenopus tropicalis" xref: Reactome:REACT_99340 "DNA strand elongation, Taeniopygia guttata" is_a: GO:0022616 ! DNA strand elongation intersection_of: GO:0022616 ! DNA strand elongation intersection_of: part_of GO:0006260 ! DNA replication relationship: part_of GO:0006260 ! DNA replication relationship: part_of GO:0006261 ! DNA-dependent DNA replication property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006275 name: regulation of DNA replication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA replication." [GOC:go_curators] subset: gosubset_prok is_a: GO:0051052 ! regulation of DNA metabolic process is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006260 ! DNA replication relationship: regulates GO:0006260 ! DNA replication property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006279 name: premeiotic DNA replication namespace: biological_process alt_id: GO:1902968 def: "The replication of DNA that precedes meiotic cell division." [GO_REF:0000060, GOC:ai, GOC:TermGenie] synonym: "DNA replication during S phase involved in meiotic cell cycle" RELATED [GOC:TermGenie] synonym: "DNA replication involved in S phase involved in meiotic cell cycle" EXACT [GOC:TermGenie] synonym: "DNA replication involved in S-phase involved in meiotic cell cycle" EXACT [GOC:TermGenie] synonym: "meiotic cell cycle DNA replication" EXACT [] synonym: "meiotic DNA replication" RELATED [GOC:mah] synonym: "meiotic DNA synthesis" RELATED [GOC:mah] synonym: "meiotic nuclear cell cycle DNA replication" EXACT [] synonym: "nuclear cell cycle DNA replication involved in meiotic cell cycle" EXACT [] synonym: "premeiotic DNA synthesis" RELATED [GOC:mah] is_a: GO:0033260 ! nuclear DNA replication is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0033260 ! nuclear DNA replication intersection_of: part_of GO:0051321 ! meiotic cell cycle relationship: part_of GO:0051321 ! meiotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006281 name: DNA repair namespace: biological_process def: "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] subset: goslim_pir subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok xref: Reactome:REACT_102034 "DNA Repair, Staphylococcus aureus N315" xref: Reactome:REACT_106650 "DNA Damage Reversal, Taeniopygia guttata" xref: Reactome:REACT_107446 "DNA Repair, Arabidopsis thaliana" xref: Reactome:REACT_107692 "DNA Damage Reversal, Gallus gallus" xref: Reactome:REACT_107752 "DNA Repair, Plasmodium falciparum" xref: Reactome:REACT_108864 "DNA Damage Reversal, Rattus norvegicus" xref: Reactome:REACT_108881 "DNA Damage Reversal, Bos taurus" xref: Reactome:REACT_108903 "DNA Repair, Xenopus tropicalis" xref: Reactome:REACT_109956 "DNA Repair, Gallus gallus" xref: Reactome:REACT_115642 "DNA repair, Gallus gallus" xref: Reactome:REACT_115836 "Fanconi Anemia Pathway in DNA repair, Gallus gallus" xref: Reactome:REACT_127 "DNA Damage Reversal, Homo sapiens" xref: Reactome:REACT_216 "DNA Repair, Homo sapiens" xref: Reactome:REACT_29531 "DNA Damage Reversal, Saccharomyces cerevisiae" xref: Reactome:REACT_29636 "DNA Damage Reversal, Staphylococcus aureus N315" xref: Reactome:REACT_78051 "DNA Damage Reversal, Canis familiaris" xref: Reactome:REACT_82907 "DNA Repair, Oryza sativa" xref: Reactome:REACT_83608 "DNA Damage Reversal, Caenorhabditis elegans" xref: Reactome:REACT_83660 "DNA Repair, Escherichia coli" xref: Reactome:REACT_84835 "DNA Damage Reversal, Dictyostelium discoideum" xref: Reactome:REACT_85522 "DNA Repair, Mus musculus" xref: Reactome:REACT_86513 "DNA Repair, Mycobacterium tuberculosis" xref: Reactome:REACT_86902 "DNA Repair, Danio rerio" xref: Reactome:REACT_88201 "DNA Repair, Drosophila melanogaster" xref: Reactome:REACT_88946 "DNA Damage Reversal, Mycobacterium tuberculosis" xref: Reactome:REACT_89524 "DNA Damage Reversal, Drosophila melanogaster" xref: Reactome:REACT_90385 "DNA Repair, Canis familiaris" xref: Reactome:REACT_90952 "DNA Damage Reversal, Arabidopsis thaliana" xref: Reactome:REACT_91094 "DNA Repair, Rattus norvegicus" xref: Reactome:REACT_91330 "DNA Repair, Bos taurus" xref: Reactome:REACT_91442 "DNA Repair, Caenorhabditis elegans" xref: Reactome:REACT_91576 "DNA Damage Reversal, Oryza sativa" xref: Reactome:REACT_92707 "DNA Repair, Taeniopygia guttata" xref: Reactome:REACT_93704 "DNA Repair, Saccharomyces cerevisiae" xref: Reactome:REACT_94204 "DNA Repair, Sus scrofa" xref: Reactome:REACT_94769 "DNA Repair, Schizosaccharomyces pombe" xref: Reactome:REACT_95050 "DNA Damage Reversal, Sus scrofa" xref: Reactome:REACT_95158 "DNA Damage Reversal, Xenopus tropicalis" xref: Reactome:REACT_96052 "DNA Repair, Dictyostelium discoideum" xref: Reactome:REACT_96452 "DNA Damage Reversal, Danio rerio" xref: Reactome:REACT_99277 "DNA Damage Reversal, Mus musculus" xref: Wikipedia:DNA_repair is_a: GO:0006259 ! DNA metabolic process is_a: GO:0006974 ! cellular response to DNA damage stimulus is_a: GO:0044710 ! single-organism metabolic process is_a: GO:0044763 ! single-organism cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006289 name: nucleotide-excision repair namespace: biological_process alt_id: GO:0045001 def: "A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977] comment: Note that although intrastrand cross-link repair is not exactly synonymous with nucleotide excision repair, nucleotide excision repair includes the repair of intrastrand cross-links. The synonym field is being used to reflect the broad substrate specificity of nucleotide excision repair. subset: gosubset_prok synonym: "intrastrand cross-link repair" RELATED [] synonym: "NER" EXACT [] synonym: "pyrimidine-dimer repair, DNA damage excision" EXACT [] xref: Reactome:REACT_103880 "Nucleotide Excision Repair, Canis familiaris" xref: Reactome:REACT_103962 "Nucleotide Excision Repair, Schizosaccharomyces pombe" xref: Reactome:REACT_106982 "Nucleotide Excision Repair, Drosophila melanogaster" xref: Reactome:REACT_109142 "Nucleotide Excision Repair, Rattus norvegicus" xref: Reactome:REACT_110113 "Nucleotide Excision Repair, Plasmodium falciparum" xref: Reactome:REACT_1826 "Nucleotide Excision Repair, Homo sapiens" xref: Reactome:REACT_30685 "Nucleotide Excision Repair, Sus scrofa" xref: Reactome:REACT_31605 "Nucleotide Excision Repair, Danio rerio" xref: Reactome:REACT_71449 "Nucleotide Excision Repair, Gallus gallus" xref: Reactome:REACT_77033 "Nucleotide Excision Repair, Oryza sativa" xref: Reactome:REACT_79939 "Nucleotide Excision Repair, Xenopus tropicalis" xref: Reactome:REACT_81923 "Nucleotide Excision Repair, Taeniopygia guttata" xref: Reactome:REACT_84438 "Nucleotide Excision Repair, Caenorhabditis elegans" xref: Reactome:REACT_85405 "Nucleotide Excision Repair, Dictyostelium discoideum" xref: Reactome:REACT_88933 "Nucleotide Excision Repair, Saccharomyces cerevisiae" xref: Reactome:REACT_91101 "Nucleotide Excision Repair, Mus musculus" xref: Reactome:REACT_96106 "Nucleotide Excision Repair, Arabidopsis thaliana" xref: Reactome:REACT_98428 "Nucleotide Excision Repair, Bos taurus" xref: Reactome:REACT_98432 "Nucleotide Excision Repair, Mycobacterium tuberculosis" is_a: GO:0006281 ! DNA repair property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006301 name: postreplication repair namespace: biological_process def: "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication." [GOC:elh] subset: gosubset_prok synonym: "postreplication DNA repair" EXACT [GOC:curators] xref: Wikipedia:Postreplication_repair is_a: GO:0006281 ! DNA repair property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006302 name: double-strand break repair namespace: biological_process def: "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh] comment: Note that the processes of nuclear double-strand break repair and mitochondrial double-strand break repair are genetically separable (PMID:22214610). To annotate gene products involved in mitochondrial double-strand break repair, please use GO:0097551 'mitochondrial double-strand break repair'. subset: gosubset_prok xref: Reactome:REACT_103570 "Double-Strand Break Repair, Mycobacterium tuberculosis" xref: Reactome:REACT_103800 "Double-Strand Break Repair, Gallus gallus" xref: Reactome:REACT_107286 "Double-Strand Break Repair, Canis familiaris" xref: Reactome:REACT_116061 "Double strand break repair, Gallus gallus" xref: Reactome:REACT_2054 "Double-Strand Break Repair, Homo sapiens" xref: Reactome:REACT_30484 "Double-Strand Break Repair, Arabidopsis thaliana" xref: Reactome:REACT_31577 "Double-Strand Break Repair, Schizosaccharomyces pombe" xref: Reactome:REACT_33123 "Double-Strand Break Repair, Oryza sativa" xref: Reactome:REACT_74735 "Double-Strand Break Repair, Dictyostelium discoideum" xref: Reactome:REACT_77568 "Double-Strand Break Repair, Xenopus tropicalis" xref: Reactome:REACT_79557 "Double-Strand Break Repair, Rattus norvegicus" xref: Reactome:REACT_79999 "Double-Strand Break Repair, Plasmodium falciparum" xref: Reactome:REACT_83524 "Double-Strand Break Repair, Taeniopygia guttata" xref: Reactome:REACT_84402 "Double-Strand Break Repair, Saccharomyces cerevisiae" xref: Reactome:REACT_85859 "Double-Strand Break Repair, Sus scrofa" xref: Reactome:REACT_95411 "Double-Strand Break Repair, Mus musculus" xref: Reactome:REACT_96237 "Double-Strand Break Repair, Drosophila melanogaster" xref: Reactome:REACT_97002 "Double-Strand Break Repair, Caenorhabditis elegans" xref: Reactome:REACT_97010 "Double-Strand Break Repair, Bos taurus" xref: Reactome:REACT_97122 "Double-Strand Break Repair, Danio rerio" is_a: GO:0006281 ! DNA repair property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006303 name: double-strand break repair via nonhomologous end joining namespace: biological_process def: "The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear." [GOC:rph, PMID:10827453, PMID:24837021] subset: gosubset_prok synonym: "NHEJ" EXACT [] xref: Reactome:REACT_100151 "Nonhomologous End-joining (NHEJ), Danio rerio" xref: Reactome:REACT_1022 "Nonhomologous End-joining (NHEJ), Homo sapiens" xref: Reactome:REACT_105598 "Nonhomologous End-joining (NHEJ), Mus musculus" xref: Reactome:REACT_108059 "Nonhomologous End-joining (NHEJ), Arabidopsis thaliana" xref: Reactome:REACT_108116 "Nonhomologous End-joining (NHEJ), Caenorhabditis elegans" xref: Reactome:REACT_108372 "Nonhomologous End-joining (NHEJ), Sus scrofa" xref: Reactome:REACT_109687 "Nonhomologous End-joining (NHEJ), Schizosaccharomyces pombe" xref: Reactome:REACT_110441 "Nonhomologous End-joining (NHEJ), Oryza sativa" xref: Reactome:REACT_114794 "Nonhomologous End-joining (NHEJ), Xenopus tropicalis" xref: Reactome:REACT_115694 "Non-homologous end joining (NHEJ), Gallus gallus" xref: Reactome:REACT_78453 "Nonhomologous End-joining (NHEJ), Dictyostelium discoideum" xref: Reactome:REACT_79261 "Nonhomologous End-joining (NHEJ), Rattus norvegicus" xref: Reactome:REACT_83788 "Nonhomologous End-joining (NHEJ), Taeniopygia guttata" xref: Reactome:REACT_86175 "Nonhomologous End-joining (NHEJ), Drosophila melanogaster" xref: Reactome:REACT_93170 "Nonhomologous End-joining (NHEJ), Gallus gallus" xref: Reactome:REACT_93631 "Nonhomologous End-joining (NHEJ), Canis familiaris" xref: Reactome:REACT_97194 "Nonhomologous End-joining (NHEJ), Bos taurus" is_a: GO:0000726 ! non-recombinational repair is_a: GO:0006302 ! double-strand break repair property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006310 name: DNA recombination namespace: biological_process def: "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok is_a: GO:0006259 ! DNA metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006312 name: mitotic recombination namespace: biological_process def: "The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous region of DNA that occurs during mitotic cell cycles." [GOC:elh] xref: Wikipedia:Mitotic_crossover is_a: GO:0006310 ! DNA recombination property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006323 name: DNA packaging namespace: biological_process def: "Any process in which DNA and associated proteins are formed into a compact, orderly structure." [GOC:mah, ISBN:0815316194] subset: goslim_pir synonym: "DNA condensation" EXACT [] synonym: "DNA organisation" EXACT [GOC:curators] synonym: "DNA organization" EXACT [GOC:curators] is_a: GO:0071103 ! DNA conformation change relationship: has_part GO:0008301 ! DNA binding, bending property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006325 name: chromatin organization namespace: biological_process def: "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GOC:mah] subset: goslim_pombe subset: goslim_yeast synonym: "chromatin organisation" EXACT [GOC:mah] synonym: "establishment or maintenance of chromatin architecture" EXACT [GOC:mah] is_a: GO:0043933 ! macromolecular complex subunit organization relationship: part_of GO:0051276 ! chromosome organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006333 name: chromatin assembly or disassembly namespace: biological_process def: "The formation or destruction of chromatin structures." [GOC:mah] synonym: "chromatin assembly/disassembly" EXACT [] is_a: GO:0006325 ! chromatin organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006334 name: nucleosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] synonym: "histone chaperone" RELATED [GOC:vw] synonym: "nucleosome modeling" EXACT [] xref: Reactome:REACT_22344 "Nucleosome assembly, Homo sapiens" is_a: GO:0006461 ! protein complex assembly is_a: GO:0034728 ! nucleosome organization is_a: GO:0065004 ! protein-DNA complex assembly relationship: part_of GO:0031497 ! chromatin assembly property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006336 name: DNA replication-independent nucleosome assembly namespace: biological_process def: "The formation of nucleosomes outside the context of DNA replication." [GOC:mah] synonym: "transcription-coupled nucleosome assembly" EXACT [] is_a: GO:0006334 ! nucleosome assembly is_a: GO:0034724 ! DNA replication-independent nucleosome organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006338 name: chromatin remodeling namespace: biological_process def: "Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820] synonym: "chromatin modeling" EXACT [] synonym: "chromatin modelling" EXACT [] synonym: "chromatin remodelling" EXACT [] is_a: GO:0016568 ! chromatin modification property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006342 name: chromatin silencing namespace: biological_process alt_id: GO:0016440 def: "Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245] comment: Note that this process is the opposite of chromatin-mediated maintenance of transcription. This regulation is exemplified by members of the Polycomb group, which maintain the inactive state of homeotic gene transcription. synonym: "chromatin-mediated maintenance of transcriptional inactivation" EXACT [] synonym: "chromatin-mediated silencing" EXACT [] synonym: "heterochromatic silencing" RELATED [] synonym: "TGS" EXACT [] synonym: "transcriptional gene silencing" EXACT [] is_a: GO:0016458 ! gene silencing is_a: GO:0045814 ! negative regulation of gene expression, epigenetic is_a: GO:0045892 ! negative regulation of transcription, DNA-templated property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006348 name: chromatin silencing at telomere namespace: biological_process def: "Repression of transcription of telomeric DNA by altering the structure of chromatin." [PMID:10219245] synonym: "heterochromatic silencing at telomere" EXACT [] synonym: "telomere chromatin silencing" EXACT [GOC:mah] synonym: "telomeric silencing" EXACT [GOC:bf] is_a: GO:0006342 ! chromatin silencing property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006351 name: transcription, DNA-templated namespace: biological_process alt_id: GO:0006350 alt_id: GO:0061018 alt_id: GO:0061022 def: "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] subset: goslim_aspergillus subset: goslim_metagenomics subset: goslim_pombe subset: gosubset_prok synonym: "cellular transcription" BROAD [] synonym: "cellular transcription, DNA-dependent" EXACT [] synonym: "DNA-dependent transcription" EXACT [] synonym: "transcription" BROAD [] synonym: "transcription regulator activity" RELATED [] synonym: "transcription, DNA-dependent" EXACT [GOC:txnOH] xref: Wikipedia:Transcription_(genetics) is_a: GO:0034645 ! cellular macromolecule biosynthetic process is_a: GO:0097659 ! nucleic acid-templated transcription relationship: part_of GO:0010467 ! gene expression property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006352 name: DNA-templated transcription, initiation namespace: biological_process def: "Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161] comment: Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation. subset: goslim_yeast subset: gosubset_prok synonym: "DNA-dependent RNA polymerase complex assembly at promoter" EXACT [] synonym: "DNA-dependent transcription, initiation" EXACT [GOC:txnOH] synonym: "initiation of DNA-dependent transcription" EXACT [GOC:jh2] synonym: "initiation of transcription, DNA-dependent" EXACT [GOC:mah] synonym: "transcription initiation factor activity" RELATED [] synonym: "transcription initiation, DNA-dependent" RELATED [GOC:jh2] is_a: GO:0032774 ! RNA biosynthetic process relationship: part_of GO:0006351 ! transcription, DNA-templated property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006353 name: DNA-templated transcription, termination namespace: biological_process def: "The cellular process that completes DNA-templated transcription; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:txnOH, ISBN:0716720094, PMID:15020047, PMID:18280161] subset: goslim_yeast subset: gosubset_prok synonym: "DNA-dependent transcription, termination" EXACT [GOC:txnOH] synonym: "termination of DNA-dependent transcription" EXACT [GOC:jh2] synonym: "termination of transcription, DNA-dependent" EXACT [GOC:mah] synonym: "transcription termination factor activity" RELATED [] synonym: "transcription termination, DNA-dependent" RELATED [GOC:jh2] synonym: "transcriptional complex disassembly" BROAD [] is_a: GO:0032774 ! RNA biosynthetic process relationship: part_of GO:0006351 ! transcription, DNA-templated property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006354 name: DNA-templated transcription, elongation namespace: biological_process def: "The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase." [GOC:mah, GOC:txnOH, PMID:15020047, PMID:18280161] subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "DNA-dependent transcription, elongation" EXACT [GOC:txnOH] synonym: "RNA elongation" BROAD [] synonym: "transcription elongation, DNA-dependent" EXACT [GOC:jh2] synonym: "transcriptional elongation, DNA-dependent" EXACT [] is_a: GO:0032774 ! RNA biosynthetic process relationship: part_of GO:0006351 ! transcription, DNA-templated property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006355 name: regulation of transcription, DNA-templated namespace: biological_process alt_id: GO:0032583 alt_id: GO:0045449 alt_id: GO:0061019 def: "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] subset: goslim_pombe subset: gosubset_prok synonym: "regulation of cellular transcription, DNA-dependent" EXACT [] synonym: "regulation of gene-specific transcription" RELATED [] synonym: "regulation of transcription, DNA-dependent" EXACT [GOC:txnOH] synonym: "transcriptional control" BROAD [] is_a: GO:0010468 ! regulation of gene expression is_a: GO:1903506 ! regulation of nucleic acid-templated transcription is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006351 ! transcription, DNA-templated relationship: regulates GO:0006351 ! transcription, DNA-templated property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006357 name: regulation of transcription from RNA polymerase II promoter namespace: biological_process alt_id: GO:0006358 alt_id: GO:0010551 def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] synonym: "global transcription regulation from Pol II promoter" RELATED [] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [] synonym: "regulation of global transcription from Pol II promoter" RELATED [] synonym: "regulation of transcription from Pol II promoter" EXACT [] synonym: "regulation of transcription from RNA polymerase II promoter, global" RELATED [] is_a: GO:0006355 ! regulation of transcription, DNA-templated intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006366 ! transcription from RNA polymerase II promoter relationship: regulates GO:0006366 ! transcription from RNA polymerase II promoter property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006364 name: rRNA processing namespace: biological_process alt_id: GO:0006365 def: "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators] subset: goslim_yeast subset: gosubset_prok synonym: "35S primary transcript processing" NARROW [] is_a: GO:0016072 ! rRNA metabolic process is_a: GO:0034470 ! ncRNA processing relationship: part_of GO:0042254 ! ribosome biogenesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006366 name: transcription from RNA polymerase II promoter namespace: biological_process alt_id: GO:0032568 alt_id: GO:0032569 def: "The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] subset: goslim_yeast synonym: "gene-specific transcription from RNA polymerase II promoter" RELATED [] synonym: "general transcription from RNA polymerase II promoter" RELATED [] synonym: "RNA polymerase II transcription factor activity" RELATED [] synonym: "specific transcription from RNA polymerase II promoter" RELATED [GOC:mah] synonym: "transcription from Pol II promoter" EXACT [] xref: Reactome:REACT_105738 "RNA Polymerase II Transcription, Bos taurus" xref: Reactome:REACT_106213 "RNA Polymerase II Transcription, Caenorhabditis elegans" xref: Reactome:REACT_108012 "RNA Polymerase II Transcription, Canis familiaris" xref: Reactome:REACT_109421 "RNA Polymerase II Transcription, Xenopus tropicalis" xref: Reactome:REACT_1366 "RNA Polymerase II Transcription, Homo sapiens" xref: Reactome:REACT_31558 "RNA Polymerase II Transcription, Taeniopygia guttata" xref: Reactome:REACT_32943 "RNA Polymerase II Transcription, Danio rerio" xref: Reactome:REACT_33538 "RNA Polymerase II Transcription, Rattus norvegicus" xref: Reactome:REACT_33583 "RNA Polymerase II Transcription, Sus scrofa" xref: Reactome:REACT_34720 "RNA Polymerase II Transcription, Schizosaccharomyces pombe" xref: Reactome:REACT_79747 "RNA Polymerase II Transcription, Plasmodium falciparum" xref: Reactome:REACT_89454 "RNA Polymerase II Transcription, Oryza sativa" xref: Reactome:REACT_89916 "RNA Polymerase II Transcription, Mus musculus" xref: Reactome:REACT_97471 "RNA Polymerase II Transcription, Arabidopsis thaliana" xref: Reactome:REACT_97536 "RNA Polymerase II Transcription, Gallus gallus" xref: Reactome:REACT_99228 "RNA Polymerase II Transcription, Drosophila melanogaster" xref: Reactome:REACT_99748 "RNA Polymerase II Transcription, Dictyostelium discoideum" xref: Reactome:REACT_99950 "RNA Polymerase II Transcription, Saccharomyces cerevisiae" is_a: GO:0006351 ! transcription, DNA-templated property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006368 name: transcription elongation from RNA polymerase II promoter namespace: biological_process def: "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH] synonym: "RNA elongation from Pol II promoter" EXACT [] synonym: "RNA polymerase II transcription elongation factor activity" RELATED [] xref: Reactome:REACT_100066 "RNA Polymerase II Transcription Elongation, Rattus norvegicus" xref: Reactome:REACT_100727 "Formation of the Early Elongation Complex, Gallus gallus" xref: Reactome:REACT_101279 "Formation of the Early Elongation Complex, Caenorhabditis elegans" xref: Reactome:REACT_101816 "Formation of the Early Elongation Complex, Schizosaccharomyces pombe" xref: Reactome:REACT_104824 "RNA Polymerase II Promoter Escape, Xenopus tropicalis" xref: Reactome:REACT_104937 "RNA Polymerase II Transcription Elongation, Mus musculus" xref: Reactome:REACT_106139 "RNA Polymerase II Promoter Escape, Danio rerio" xref: Reactome:REACT_106149 "RNA Polymerase II Promoter Escape, Oryza sativa" xref: Reactome:REACT_107633 "RNA Polymerase II Transcription Elongation, Arabidopsis thaliana" xref: Reactome:REACT_107789 "RNA Polymerase II Promoter Escape, Saccharomyces cerevisiae" xref: Reactome:REACT_108831 "Formation of RNA Pol II elongation complex, Xenopus tropicalis" xref: Reactome:REACT_109274 "RNA Polymerase II Promoter Escape, Caenorhabditis elegans" xref: Reactome:REACT_109291 "Formation of the Early Elongation Complex, Mus musculus" xref: Reactome:REACT_110182 "Formation of RNA Pol II elongation complex, Mus musculus" xref: Reactome:REACT_110507 "RNA Polymerase II Transcription Elongation, Danio rerio" xref: Reactome:REACT_112408 "Formation of RNA Pol II elongation complex, Drosophila melanogaster" xref: Reactome:REACT_112630 "Formation of RNA Pol II elongation complex, Schizosaccharomyces pombe" xref: Reactome:REACT_113325 "Formation of RNA Pol II elongation complex, Caenorhabditis elegans" xref: Reactome:REACT_115524 "Formation of RNA Pol II elongation complex, Danio rerio" xref: Reactome:REACT_1845 "Formation of RNA Pol II elongation complex, Homo sapiens" xref: Reactome:REACT_2089 "RNA Polymerase II Promoter Escape, Homo sapiens" xref: Reactome:REACT_28524 "Formation of RNA Pol II elongation complex, Bos taurus" xref: Reactome:REACT_28692 "Formation of the Early Elongation Complex, Danio rerio" xref: Reactome:REACT_28768 "RNA Polymerase II Transcription Elongation, Xenopus tropicalis" xref: Reactome:REACT_29367 "RNA Polymerase II Transcription Elongation, Taeniopygia guttata" xref: Reactome:REACT_29380 "Formation of the Early Elongation Complex, Arabidopsis thaliana" xref: Reactome:REACT_31308 "Formation of the Early Elongation Complex, Rattus norvegicus" xref: Reactome:REACT_31396 "RNA Polymerase II Promoter Escape, Mus musculus" xref: Reactome:REACT_31533 "RNA Polymerase II Transcription Elongation, Canis familiaris" xref: Reactome:REACT_32311 "RNA Polymerase II Transcription Elongation, Bos taurus" xref: Reactome:REACT_32712 "Formation of RNA Pol II elongation complex, Canis familiaris" xref: Reactome:REACT_32829 "RNA Polymerase II Promoter Escape, Arabidopsis thaliana" xref: Reactome:REACT_55595 "RNA Polymerase II Promoter Escape, Schizosaccharomyces pombe" xref: Reactome:REACT_6274 "HIV-1 Transcription Elongation, Homo sapiens" xref: Reactome:REACT_66965 "RNA Polymerase II Promoter Escape, Dictyostelium discoideum" xref: Reactome:REACT_77610 "RNA Polymerase II Promoter Escape, Bos taurus" xref: Reactome:REACT_78366 "Formation of RNA Pol II elongation complex, Rattus norvegicus" xref: Reactome:REACT_81662 "RNA Polymerase II Promoter Escape, Drosophila melanogaster" xref: Reactome:REACT_81750 "RNA Polymerase II Transcription Elongation, Saccharomyces cerevisiae" xref: Reactome:REACT_81845 "RNA Polymerase II Promoter Escape, Rattus norvegicus" xref: Reactome:REACT_833 "RNA Polymerase II Transcription Elongation, Homo sapiens" xref: Reactome:REACT_83871 "Formation of the Early Elongation Complex, Dictyostelium discoideum" xref: Reactome:REACT_84247 "Formation of the Early Elongation Complex, Taeniopygia guttata" xref: Reactome:REACT_84349 "Formation of the Early Elongation Complex, Oryza sativa" xref: Reactome:REACT_846 "Formation of the Early Elongation Complex, Homo sapiens" xref: Reactome:REACT_87946 "RNA Polymerase II Transcription Elongation, Caenorhabditis elegans" xref: Reactome:REACT_89781 "RNA Polymerase II Transcription Elongation, Gallus gallus" xref: Reactome:REACT_90242 "RNA Polymerase II Promoter Escape, Gallus gallus" xref: Reactome:REACT_91644 "Formation of the Early Elongation Complex, Xenopus tropicalis" xref: Reactome:REACT_92647 "Formation of the Early Elongation Complex, Canis familiaris" xref: Reactome:REACT_92836 "RNA Polymerase II Transcription Elongation, Drosophila melanogaster" xref: Reactome:REACT_93156 "Formation of the Early Elongation Complex, Bos taurus" xref: Reactome:REACT_93741 "RNA Polymerase II Transcription Elongation, Schizosaccharomyces pombe" xref: Reactome:REACT_94090 "RNA Polymerase II Transcription Elongation, Oryza sativa" xref: Reactome:REACT_96685 "RNA Polymerase II Promoter Escape, Canis familiaris" xref: Reactome:REACT_97522 "Formation of the Early Elongation Complex, Drosophila melanogaster" xref: Reactome:REACT_99278 "RNA Polymerase II Transcription Elongation, Dictyostelium discoideum" xref: Reactome:REACT_99528 "Formation of the Early Elongation Complex, Saccharomyces cerevisiae" is_a: GO:0006354 ! DNA-templated transcription, elongation relationship: part_of GO:0006366 ! transcription from RNA polymerase II promoter property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006383 name: transcription from RNA polymerase III promoter namespace: biological_process def: "The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH] subset: goslim_yeast subset: gosubset_prok synonym: "RNA polymerase III transcription factor activity" RELATED [] synonym: "transcription from Pol III promoter" EXACT [] xref: Reactome:REACT_100945 "Initiation of RNA Polymerase III Productive Transcription, Schizosaccharomyces pombe" xref: Reactome:REACT_101038 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters, Rattus norvegicus" xref: Reactome:REACT_101551 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Canis familiaris" xref: Reactome:REACT_101656 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters, Rattus norvegicus" xref: Reactome:REACT_101661 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Mus musculus" xref: Reactome:REACT_101700 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters, Sus scrofa" xref: Reactome:REACT_101771 "RNA Polymerase III Promoter Opening at Type 1 Promoters, Gallus gallus" xref: Reactome:REACT_101901 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Danio rerio" xref: Reactome:REACT_102138 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters, Bos taurus" xref: Reactome:REACT_102603 "RNA Polymerase III Transcription, Gallus gallus" xref: Reactome:REACT_102683 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters, Rattus norvegicus" xref: Reactome:REACT_103091 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Caenorhabditis elegans" xref: Reactome:REACT_103169 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters, Taeniopygia guttata" xref: Reactome:REACT_103226 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters, Drosophila melanogaster" xref: Reactome:REACT_103412 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters, Mus musculus" xref: Reactome:REACT_103650 "RNA Polymerase III Transcription, Taeniopygia guttata" xref: Reactome:REACT_103786 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters, Sus scrofa" xref: Reactome:REACT_104805 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Schizosaccharomyces pombe" xref: Reactome:REACT_105112 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters, Sus scrofa" xref: Reactome:REACT_105558 "Resumption of RNA Polymerase III Productive Transcription, Dictyostelium discoideum" xref: Reactome:REACT_105661 "RNA Polymerase III Transcription, Schizosaccharomyces pombe" xref: Reactome:REACT_106059 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters, Caenorhabditis elegans" xref: Reactome:REACT_1061 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters, Homo sapiens" xref: Reactome:REACT_106142 "Initiation of RNA Polymerase III Productive Transcription, Gallus gallus" xref: Reactome:REACT_106447 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters, Caenorhabditis elegans" xref: Reactome:REACT_106560 "Initiation of RNA Polymerase III Productive Transcription, Sus scrofa" xref: Reactome:REACT_106688 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters, Bos taurus" xref: Reactome:REACT_106837 "Resumption of RNA Polymerase III Productive Transcription, Mus musculus" xref: Reactome:REACT_107790 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters, Taeniopygia guttata" xref: Reactome:REACT_107815 "RNA Polymerase III Transcription, Saccharomyces cerevisiae" xref: Reactome:REACT_108150 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Gallus gallus" xref: Reactome:REACT_108254 "RNA Polymerase III Promoter Opening at Type 1 Promoters, Mus musculus" xref: Reactome:REACT_108736 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Sus scrofa" xref: Reactome:REACT_108779 "Initiation of RNA Polymerase III Productive Transcription, Canis familiaris" xref: Reactome:REACT_109038 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters, Xenopus tropicalis" xref: Reactome:REACT_109056 "Resumption of RNA Polymerase III Productive Transcription, Schizosaccharomyces pombe" xref: Reactome:REACT_109134 "Initiation of RNA Polymerase III Productive Transcription, Drosophila melanogaster" xref: Reactome:REACT_109293 "RNA Polymerase III Productive Transcription, Mus musculus" xref: Reactome:REACT_109350 "Resumption of RNA Polymerase III Productive Transcription, Drosophila melanogaster" xref: Reactome:REACT_109707 "RNA Polymerase III Productive Transcription, Xenopus tropicalis" xref: Reactome:REACT_109747 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters, Drosophila melanogaster" xref: Reactome:REACT_109934 "RNA Polymerase III Promoter Opening at Type 1 Promoters, Drosophila melanogaster" xref: Reactome:REACT_109938 "Initiation of RNA Polymerase III Productive Transcription, Oryza sativa" xref: Reactome:REACT_110233 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Taeniopygia guttata" xref: Reactome:REACT_110354 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Drosophila melanogaster" xref: Reactome:REACT_110533 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters, Rattus norvegicus" xref: Reactome:REACT_110624 "Initiation of RNA Polymerase III Productive Transcription, Danio rerio" xref: Reactome:REACT_112623 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters, Drosophila melanogaster" xref: Reactome:REACT_112804 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters, Dictyostelium discoideum" xref: Reactome:REACT_113692 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters, Dictyostelium discoideum" xref: Reactome:REACT_114988 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters, Drosophila melanogaster" xref: Reactome:REACT_1179 "Initiation of RNA Polymerase III Productive Transcription, Homo sapiens" xref: Reactome:REACT_118261 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters, Caenorhabditis elegans" xref: Reactome:REACT_118310 "RNA Polymerase III Promoter Opening at Type 1 Promoters, Caenorhabditis elegans" xref: Reactome:REACT_118481 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters, Caenorhabditis elegans" xref: Reactome:REACT_1241 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters, Homo sapiens" xref: Reactome:REACT_1371 "RNA Polymerase III Transcription, Homo sapiens" xref: Reactome:REACT_1374 "Resumption of RNA Polymerase III Productive Transcription, Homo sapiens" xref: Reactome:REACT_1616 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters, Homo sapiens" xref: Reactome:REACT_2178 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters, Homo sapiens" xref: Reactome:REACT_2210 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters, Homo sapiens" xref: Reactome:REACT_2248 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Homo sapiens" xref: Reactome:REACT_2251 "RNA Polymerase III Productive Transcription, Homo sapiens" xref: Reactome:REACT_251 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters, Homo sapiens" xref: Reactome:REACT_28871 "RNA Polymerase III Productive Transcription, Canis familiaris" xref: Reactome:REACT_28926 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Xenopus tropicalis" xref: Reactome:REACT_29249 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Bos taurus" xref: Reactome:REACT_29589 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters, Canis familiaris" xref: Reactome:REACT_30206 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters, Canis familiaris" xref: Reactome:REACT_30383 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters, Taeniopygia guttata" xref: Reactome:REACT_30530 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters, Canis familiaris" xref: Reactome:REACT_30710 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters, Taeniopygia guttata" xref: Reactome:REACT_30749 "RNA Polymerase III Promoter Opening at Type 1 Promoters, Rattus norvegicus" xref: Reactome:REACT_30852 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters, Drosophila melanogaster" xref: Reactome:REACT_30868 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters, Canis familiaris" xref: Reactome:REACT_31576 "Resumption of RNA Polymerase III Productive Transcription, Xenopus tropicalis" xref: Reactome:REACT_31708 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters, Drosophila melanogaster" xref: Reactome:REACT_32551 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters, Mus musculus" xref: Reactome:REACT_32580 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters, Canis familiaris" xref: Reactome:REACT_34048 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters, Bos taurus" xref: Reactome:REACT_43442 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters, Bos taurus" xref: Reactome:REACT_50555 "RNA Polymerase III Promoter Opening at Type 1 Promoters, Bos taurus" xref: Reactome:REACT_76991 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters, Rattus norvegicus" xref: Reactome:REACT_77583 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters, Gallus gallus" xref: Reactome:REACT_77734 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters, Rattus norvegicus" xref: Reactome:REACT_77763 "RNA Polymerase III Productive Transcription, Rattus norvegicus" xref: Reactome:REACT_77942 "Initiation of RNA Polymerase III Productive Transcription, Mus musculus" xref: Reactome:REACT_78034 "Resumption of RNA Polymerase III Productive Transcription, Taeniopygia guttata" xref: Reactome:REACT_78101 "Resumption of RNA Polymerase III Productive Transcription, Danio rerio" xref: Reactome:REACT_78330 "RNA Polymerase III Promoter Opening at Type 1 Promoters, Xenopus tropicalis" xref: Reactome:REACT_78526 "RNA Polymerase III Productive Transcription, Taeniopygia guttata" xref: Reactome:REACT_79030 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Rattus norvegicus" xref: Reactome:REACT_79212 "Resumption of RNA Polymerase III Productive Transcription, Rattus norvegicus" xref: Reactome:REACT_79230 "RNA Polymerase III Transcription, Caenorhabditis elegans" xref: Reactome:REACT_796 "RNA Polymerase III Promoter Opening at Type 1 Promoters, Homo sapiens" xref: Reactome:REACT_79674 "RNA Polymerase III Transcription, Xenopus tropicalis" xref: Reactome:REACT_79928 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters, Canis familiaris" xref: Reactome:REACT_80506 "RNA Polymerase III Productive Transcription, Gallus gallus" xref: Reactome:REACT_80530 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters, Danio rerio" xref: Reactome:REACT_80924 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Arabidopsis thaliana" xref: Reactome:REACT_81033 "RNA Polymerase III Productive Transcription, Schizosaccharomyces pombe" xref: Reactome:REACT_81681 "Resumption of RNA Polymerase III Productive Transcription, Canis familiaris" xref: Reactome:REACT_82476 "RNA Polymerase III Productive Transcription, Sus scrofa" xref: Reactome:REACT_82823 "RNA Polymerase III Transcription, Bos taurus" xref: Reactome:REACT_82958 "RNA Polymerase III Transcription, Rattus norvegicus" xref: Reactome:REACT_83072 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters, Gallus gallus" xref: Reactome:REACT_83162 "Resumption of RNA Polymerase III Productive Transcription, Gallus gallus" xref: Reactome:REACT_83237 "RNA Polymerase III Transcription, Danio rerio" xref: Reactome:REACT_83573 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters, Danio rerio" xref: Reactome:REACT_83679 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters, Mus musculus" xref: Reactome:REACT_83791 "RNA Polymerase III Promoter Opening at Type 1 Promoters, Taeniopygia guttata" xref: Reactome:REACT_84005 "RNA Polymerase III Transcription, Sus scrofa" xref: Reactome:REACT_84052 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters, Xenopus tropicalis" xref: Reactome:REACT_84174 "RNA Polymerase III Transcription, Canis familiaris" xref: Reactome:REACT_84770 "RNA Polymerase III Transcription, Arabidopsis thaliana" xref: Reactome:REACT_85321 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters, Gallus gallus" xref: Reactome:REACT_85665 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters, Danio rerio" xref: Reactome:REACT_85700 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters, Sus scrofa" xref: Reactome:REACT_85938 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters, Gallus gallus" xref: Reactome:REACT_86188 "Initiation of RNA Polymerase III Productive Transcription, Dictyostelium discoideum" xref: Reactome:REACT_86214 "RNA Polymerase III Productive Transcription, Danio rerio" xref: Reactome:REACT_86477 "Resumption of RNA Polymerase III Productive Transcription, Sus scrofa" xref: Reactome:REACT_86680 "RNA Polymerase III Productive Transcription, Bos taurus" xref: Reactome:REACT_87495 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters, Danio rerio" xref: Reactome:REACT_88180 "RNA Polymerase III Promoter Opening at Type 1 Promoters, Canis familiaris" xref: Reactome:REACT_88328 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters, Taeniopygia guttata" xref: Reactome:REACT_89113 "Initiation of RNA Polymerase III Productive Transcription, Bos taurus" xref: Reactome:REACT_89159 "RNA Polymerase III Productive Transcription, Drosophila melanogaster" xref: Reactome:REACT_89744 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters, Mus musculus" xref: Reactome:REACT_90232 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters, Mus musculus" xref: Reactome:REACT_90884 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters, Sus scrofa" xref: Reactome:REACT_90929 "Initiation of RNA Polymerase III Productive Transcription, Taeniopygia guttata" xref: Reactome:REACT_90945 "Initiation of RNA Polymerase III Productive Transcription, Arabidopsis thaliana" xref: Reactome:REACT_90947 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters, Danio rerio" xref: Reactome:REACT_91182 "RNA Polymerase III Transcription, Drosophila melanogaster" xref: Reactome:REACT_91223 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters, Taeniopygia guttata" xref: Reactome:REACT_91433 "Initiation of RNA Polymerase III Productive Transcription, Rattus norvegicus" xref: Reactome:REACT_92510 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters, Bos taurus" xref: Reactome:REACT_92565 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters, Gallus gallus" xref: Reactome:REACT_92674 "RNA Polymerase III Promoter Opening at Type 1 Promoters, Sus scrofa" xref: Reactome:REACT_92814 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters, Xenopus tropicalis" xref: Reactome:REACT_92970 "RNA Polymerase III Transcription, Oryza sativa" xref: Reactome:REACT_93003 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters, Xenopus tropicalis" xref: Reactome:REACT_93041 "RNA Polymerase III Productive Transcription, Oryza sativa" xref: Reactome:REACT_93262 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Oryza sativa" xref: Reactome:REACT_93305 "Resumption of RNA Polymerase III Productive Transcription, Arabidopsis thaliana" xref: Reactome:REACT_93548 "RNA Polymerase III Transcription, Dictyostelium discoideum" xref: Reactome:REACT_93709 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites, Dictyostelium discoideum" xref: Reactome:REACT_93754 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters, Gallus gallus" xref: Reactome:REACT_93859 "RNA Polymerase III Productive Transcription, Arabidopsis thaliana" xref: Reactome:REACT_94189 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters, Xenopus tropicalis" xref: Reactome:REACT_94421 "RNA Polymerase III Transcription, Mus musculus" xref: Reactome:REACT_94567 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters, Xenopus tropicalis" xref: Reactome:REACT_94753 "Resumption of RNA Polymerase III Productive Transcription, Oryza sativa" xref: Reactome:REACT_96798 "Resumption of RNA Polymerase III Productive Transcription, Caenorhabditis elegans" xref: Reactome:REACT_97406 "Initiation of RNA Polymerase III Productive Transcription, Xenopus tropicalis" xref: Reactome:REACT_97559 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters, Sus scrofa" xref: Reactome:REACT_98079 "RNA Polymerase III Productive Transcription, Dictyostelium discoideum" xref: Reactome:REACT_98254 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters, Bos taurus" xref: Reactome:REACT_98466 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters, Danio rerio" xref: Reactome:REACT_98470 "Resumption of RNA Polymerase III Productive Transcription, Bos taurus" xref: Reactome:REACT_98660 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters, Mus musculus" xref: Reactome:REACT_98770 "RNA Polymerase III Productive Transcription, Caenorhabditis elegans" xref: Reactome:REACT_99332 "RNA Polymerase III Promoter Opening at Type 1 Promoters, Danio rerio" xref: Reactome:REACT_99492 "Initiation of RNA Polymerase III Productive Transcription, Caenorhabditis elegans" is_a: GO:0006351 ! transcription, DNA-templated property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006384 name: transcription initiation from RNA polymerase III promoter namespace: biological_process def: "Any process involved in the assembly of the RNA polymerase III preinitiation complex (PIC) at an RNA polymerase III promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH] comment: Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation. synonym: "transcription initiation from Pol III promoter" EXACT [] is_a: GO:0006352 ! DNA-templated transcription, initiation relationship: part_of GO:0006383 ! transcription from RNA polymerase III promoter property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006385 name: transcription elongation from RNA polymerase III promoter namespace: biological_process def: "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase III promoter by the addition of ribonucleotides catalyzed by RNA polymerase III." [GOC:mah, GOC:txnOH] synonym: "RNA elongation from Pol III promoter" EXACT [] synonym: "RNA polymerase III transcription elongation factor activity" RELATED [] xref: Reactome:REACT_100029 "RNA Polymerase III Chain Elongation, Danio rerio" xref: Reactome:REACT_104942 "RNA Polymerase III Chain Elongation, Caenorhabditis elegans" xref: Reactome:REACT_109063 "RNA Polymerase III Chain Elongation, Taeniopygia guttata" xref: Reactome:REACT_28198 "RNA Polymerase III Chain Elongation, Bos taurus" xref: Reactome:REACT_33298 "RNA Polymerase III Chain Elongation, Oryza sativa" xref: Reactome:REACT_33917 "RNA Polymerase III Chain Elongation, Arabidopsis thaliana" xref: Reactome:REACT_756 "RNA Polymerase III Chain Elongation, Homo sapiens" xref: Reactome:REACT_77630 "RNA Polymerase III Chain Elongation, Dictyostelium discoideum" xref: Reactome:REACT_78831 "RNA Polymerase III Chain Elongation, Saccharomyces cerevisiae" xref: Reactome:REACT_78988 "RNA Polymerase III Chain Elongation, Xenopus tropicalis" xref: Reactome:REACT_79358 "RNA Polymerase III Chain Elongation, Canis familiaris" xref: Reactome:REACT_83012 "RNA Polymerase III Chain Elongation, Drosophila melanogaster" xref: Reactome:REACT_89687 "RNA Polymerase III Chain Elongation, Rattus norvegicus" xref: Reactome:REACT_91878 "RNA Polymerase III Chain Elongation, Mus musculus" xref: Reactome:REACT_94842 "RNA Polymerase III Chain Elongation, Schizosaccharomyces pombe" xref: Reactome:REACT_94891 "RNA Polymerase III Chain Elongation, Gallus gallus" xref: Reactome:REACT_97511 "RNA Polymerase III Chain Elongation, Sus scrofa" is_a: GO:0006354 ! DNA-templated transcription, elongation relationship: part_of GO:0006383 ! transcription from RNA polymerase III promoter property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006388 name: tRNA splicing, via endonucleolytic cleavage and ligation namespace: biological_process def: "Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897, PMID:9582290] comment: Note that while typically associated with tRNA splicing, splicing via endonucleolytic cleavages and subsequent ligation of the free exon ends is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis. subset: gosubset_prok synonym: "tRNA-Y splicing" NARROW [] is_a: GO:0000394 ! RNA splicing, via endonucleolytic cleavage and ligation is_a: GO:0008033 ! tRNA processing property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006396 name: RNA processing namespace: biological_process alt_id: GO:0006394 def: "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] subset: goslim_pir subset: gosubset_prok xref: Wikipedia:Post-transcriptional_modification is_a: GO:0016070 ! RNA metabolic process relationship: part_of GO:0010467 ! gene expression property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006397 name: mRNA processing namespace: biological_process def: "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast subset: gosubset_prok synonym: "mRNA maturation" RELATED [] xref: Reactome:REACT_100203 "Processing of Capped Intronless Pre-mRNA, Dictyostelium discoideum" xref: Reactome:REACT_107308 "Processing of Capped Intronless Pre-mRNA, Xenopus tropicalis" xref: Reactome:REACT_109953 "Processing of Capped Intronless Pre-mRNA, Canis familiaris" xref: Reactome:REACT_113864 "Processing of Capped Intronless Pre-mRNA, Saccharomyces cerevisiae" xref: Reactome:REACT_114358 "Processing of Capped Intronless Pre-mRNA, Schizosaccharomyces pombe" xref: Reactome:REACT_115262 "Processing of Capped Intronless Pre-mRNA, Arabidopsis thaliana" xref: Reactome:REACT_1768 "Processing of Capped Intronless Pre-mRNA, Homo sapiens" xref: Reactome:REACT_32742 "Processing of Capped Intronless Pre-mRNA, Bos taurus" xref: Reactome:REACT_33642 "Processing of Capped Intronless Pre-mRNA, Caenorhabditis elegans" xref: Reactome:REACT_82691 "Processing of Capped Intronless Pre-mRNA, Gallus gallus" xref: Reactome:REACT_90366 "Processing of Capped Intronless Pre-mRNA, Drosophila melanogaster" xref: Reactome:REACT_91511 "Processing of Capped Intronless Pre-mRNA, Danio rerio" xref: Reactome:REACT_93186 "Processing of Capped Intronless Pre-mRNA, Sus scrofa" xref: Reactome:REACT_94083 "Processing of Capped Intronless Pre-mRNA, Taeniopygia guttata" xref: Reactome:REACT_96661 "Processing of Capped Intronless Pre-mRNA, Oryza sativa" xref: Reactome:REACT_97412 "Processing of Capped Intronless Pre-mRNA, Rattus norvegicus" xref: Reactome:REACT_97436 "Processing of Capped Intronless Pre-mRNA, Mus musculus" is_a: GO:0006396 ! RNA processing is_a: GO:0016071 ! mRNA metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006399 name: tRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established." [ISBN:0198506732] subset: goslim_chembl subset: goslim_generic subset: goslim_pombe subset: gosubset_prok synonym: "tRNA metabolism" EXACT [] is_a: GO:0034660 ! ncRNA metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006400 name: tRNA modification namespace: biological_process alt_id: GO:0016549 def: "The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators] comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'. subset: gosubset_prok synonym: "tRNA editing" NARROW [GOC:hjd] is_a: GO:0008033 ! tRNA processing is_a: GO:0009451 ! RNA modification property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006401 name: RNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] subset: goslim_yeast subset: gosubset_prok synonym: "RNA breakdown" EXACT [] synonym: "RNA catabolism" EXACT [] synonym: "RNA degradation" EXACT [] is_a: GO:0016070 ! RNA metabolic process is_a: GO:0034655 ! nucleobase-containing compound catabolic process is_a: GO:0044265 ! cellular macromolecule catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006402 name: mRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] subset: gosubset_prok synonym: "mRNA breakdown" EXACT [] synonym: "mRNA catabolism" EXACT [] synonym: "mRNA decay" RELATED [GOC:ascb_2010, GOC:dph, GOC:tb] synonym: "mRNA degradation" EXACT [] is_a: GO:0006401 ! RNA catabolic process is_a: GO:0016071 ! mRNA metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006403 name: RNA localization namespace: biological_process def: "A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai] subset: gosubset_prok synonym: "establishment and maintenance of RNA localization" EXACT [] synonym: "RNA localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006405 name: RNA export from nucleus namespace: biological_process def: "The directed movement of RNA from the nucleus to the cytoplasm." [GOC:ma] synonym: "RNA export from cell nucleus" EXACT [] synonym: "RNA export out of nucleus" EXACT [] synonym: "RNA transport from nucleus to cytoplasm" EXACT [] synonym: "RNA-nucleus export" EXACT [] xref: Reactome:REACT_1004 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC, Homo sapiens" xref: Reactome:REACT_104043 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC, Danio rerio" xref: Reactome:REACT_108003 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC, Bos taurus" xref: Reactome:REACT_114184 "Recruitment of TAP to the EJC, Drosophila melanogaster" xref: Reactome:REACT_1334 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC, Homo sapiens" xref: Reactome:REACT_29222 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC, Mus musculus" xref: Reactome:REACT_30837 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC, Rattus norvegicus" xref: Reactome:REACT_30884 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC, Xenopus tropicalis" xref: Reactome:REACT_53 "Recruitment of TAP to the EJC, Homo sapiens" xref: Reactome:REACT_78063 "Recruitment of TAP to the EJC, Xenopus tropicalis" xref: Reactome:REACT_80132 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC, Xenopus tropicalis" xref: Reactome:REACT_80198 "Recruitment of TAP to the EJC, Mus musculus" xref: Reactome:REACT_80579 "Recruitment of TAP to the EJC, Danio rerio" xref: Reactome:REACT_81658 "Recruitment of TAP to the EJC, Bos taurus" xref: Reactome:REACT_82156 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC, Bos taurus" xref: Reactome:REACT_82661 "Recruitment of TAP to the EJC, Canis familiaris" xref: Reactome:REACT_84373 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC, Danio rerio" xref: Reactome:REACT_84418 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC, Canis familiaris" xref: Reactome:REACT_85495 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC, Canis familiaris" xref: Reactome:REACT_86488 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC, Canis familiaris" xref: Reactome:REACT_87758 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC, Xenopus tropicalis" xref: Reactome:REACT_89603 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC, Rattus norvegicus" xref: Reactome:REACT_904 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC, Homo sapiens" xref: Reactome:REACT_90560 "Recruitment of TAP to the EJC, Rattus norvegicus" xref: Reactome:REACT_91473 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC, Rattus norvegicus" xref: Reactome:REACT_92226 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC, Mus musculus" xref: Reactome:REACT_95332 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC, Bos taurus" xref: Reactome:REACT_98342 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC, Mus musculus" xref: Reactome:REACT_99708 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC, Danio rerio" is_a: GO:0050658 ! RNA transport is_a: GO:0051168 ! nuclear export property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006406 name: mRNA export from nucleus namespace: biological_process def: "The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma] synonym: "mRNA export from cell nucleus" EXACT [] synonym: "mRNA export out of nucleus" EXACT [] synonym: "mRNA transport from nucleus to cytoplasm" EXACT [] synonym: "mRNA-nucleus export" EXACT [] xref: Reactome:REACT_100171 "Release of the SLBP independent Histone mRNA from the NPC, Canis familiaris" xref: Reactome:REACT_100279 "Transport of the export-competent complex through the NPC, Drosophila melanogaster" xref: Reactome:REACT_100965 "Transport of Mature Transcript to Cytoplasm, Canis familiaris" xref: Reactome:REACT_102835 "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC, Xenopus tropicalis" xref: Reactome:REACT_102954 "Transport of Mature Transcript to Cytoplasm, Rattus norvegicus" xref: Reactome:REACT_103864 "Release of the SLBP independent Histone mRNA from the NPC, Rattus norvegicus" xref: Reactome:REACT_103981 "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex, Danio rerio" xref: Reactome:REACT_1044 "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex, Homo sapiens" xref: Reactome:REACT_104948 "Transport of Mature mRNAs Derived from Intronless Transcripts, Danio rerio" xref: Reactome:REACT_105234 "Transport of the export-competent complex through the NPC, Rattus norvegicus" xref: Reactome:REACT_105457 "Docking of Mature Replication Dependent Histone mRNA with the NPC, Canis familiaris" xref: Reactome:REACT_106001 "Release from the NPC and Disassembly of the mRNP, Canis familiaris" xref: Reactome:REACT_106656 "Transport of Mature Transcript to Cytoplasm, Bos taurus" xref: Reactome:REACT_107365 "Transport of Mature mRNA derived from an Intron-Containing Transcript, Taeniopygia guttata" xref: Reactome:REACT_107514 "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex, Mus musculus" xref: Reactome:REACT_108228 "Transport of Mature mRNA derived from an Intron-Containing Transcript, Bos taurus" xref: Reactome:REACT_108856 "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex, Rattus norvegicus" xref: Reactome:REACT_109933 "Docking of Mature Replication Dependent Histone mRNA with the NPC, Rattus norvegicus" xref: Reactome:REACT_109937 "Docking of Mature Histone mRNA complex:TAP at the NPC, Mus musculus" xref: Reactome:REACT_112057 "Docking of Mature Replication Dependent Histone mRNA with the NPC, Danio rerio" xref: Reactome:REACT_113695 "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC, Danio rerio" xref: Reactome:REACT_114603 "Docking of Mature Histone mRNA complex:TAP at the NPC, Danio rerio" xref: Reactome:REACT_1228 "Release from the NPC and Disassembly of the mRNP, Homo sapiens" xref: Reactome:REACT_1281 "Transport of Mature Transcript to Cytoplasm, Homo sapiens" xref: Reactome:REACT_1356 "Release of the SLBP independent Histone mRNA from the NPC, Homo sapiens" xref: Reactome:REACT_138 "Docking of the TAP:EJC Complex with the NPC, Homo sapiens" xref: Reactome:REACT_1597 "Transport of Mature mRNA derived from an Intron-Containing Transcript, Homo sapiens" xref: Reactome:REACT_1604 "Docking of Mature Replication Dependent Histone mRNA with the NPC, Homo sapiens" xref: Reactome:REACT_1799 "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC, Homo sapiens" xref: Reactome:REACT_1897 "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC, Homo sapiens" xref: Reactome:REACT_2104 "Transport of the export-competent complex through the NPC, Homo sapiens" xref: Reactome:REACT_29248 "Docking of Mature Histone mRNA complex:TAP at the NPC, Xenopus tropicalis" xref: Reactome:REACT_30031 "Docking of Mature Histone mRNA complex:TAP at the NPC, Rattus norvegicus" xref: Reactome:REACT_30081 "Docking of Mature Histone mRNA complex:TAP at the NPC, Canis familiaris" xref: Reactome:REACT_30429 "Transport of Mature Transcript to Cytoplasm, Drosophila melanogaster" xref: Reactome:REACT_30966 "Transport of Mature Transcript to Cytoplasm, Taeniopygia guttata" xref: Reactome:REACT_33590 "Transport of Mature Transcript to Cytoplasm, Mus musculus" xref: Reactome:REACT_338 "Transport of Mature mRNAs Derived from Intronless Transcripts, Homo sapiens" xref: Reactome:REACT_34117 "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC, Canis familiaris" xref: Reactome:REACT_52228 "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC, Bos taurus" xref: Reactome:REACT_61073 "Docking of Mature Replication Dependent Histone mRNA with the NPC, Bos taurus" xref: Reactome:REACT_696 "Docking of Mature Histone mRNA complex:TAP at the NPC, Homo sapiens" xref: Reactome:REACT_78291 "Docking of Mature Replication Dependent Histone mRNA with the NPC, Xenopus tropicalis" xref: Reactome:REACT_80859 "Release of the SLBP independent Histone mRNA from the NPC, Xenopus tropicalis" xref: Reactome:REACT_81039 "Release of the SLBP independent Histone mRNA from the NPC, Danio rerio" xref: Reactome:REACT_81535 "Transport of Mature mRNA derived from an Intron-Containing Transcript, Xenopus tropicalis" xref: Reactome:REACT_81663 "Docking of Mature Replication Dependent Histone mRNA with the NPC, Mus musculus" xref: Reactome:REACT_81712 "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC, Mus musculus" xref: Reactome:REACT_82141 "Transport of Mature mRNA derived from an Intron-Containing Transcript, Rattus norvegicus" xref: Reactome:REACT_82514 "Transport of Mature mRNAs Derived from Intronless Transcripts, Rattus norvegicus" xref: Reactome:REACT_82894 "Transport of Mature mRNAs Derived from Intronless Transcripts, Bos taurus" xref: Reactome:REACT_83050 "Release of the SLBP independent Histone mRNA from the NPC, Bos taurus" xref: Reactome:REACT_83394 "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC, Canis familiaris" xref: Reactome:REACT_83855 "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC, Danio rerio" xref: Reactome:REACT_84109 "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex, Canis familiaris" xref: Reactome:REACT_85191 "Release of the SLBP independent Histone mRNA from the NPC, Mus musculus" xref: Reactome:REACT_85251 "Release from the NPC and Disassembly of the mRNP, Danio rerio" xref: Reactome:REACT_86131 "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC, Xenopus tropicalis" xref: Reactome:REACT_87203 "Transport of the export-competent complex through the NPC, Canis familiaris" xref: Reactome:REACT_87607 "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC, Rattus norvegicus" xref: Reactome:REACT_89199 "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC, Mus musculus" xref: Reactome:REACT_89255 "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC, Bos taurus" xref: Reactome:REACT_90322 "Transport of Mature mRNAs Derived from Intronless Transcripts, Xenopus tropicalis" xref: Reactome:REACT_90737 "Transport of the export-competent complex through the NPC, Danio rerio" xref: Reactome:REACT_91492 "Transport of the export-competent complex through the NPC, Taeniopygia guttata" xref: Reactome:REACT_92414 "Transport of the export-competent complex through the NPC, Mus musculus" xref: Reactome:REACT_93318 "Transport of Mature mRNAs Derived from Intronless Transcripts, Mus musculus" xref: Reactome:REACT_93526 "Transport of Mature Transcript to Cytoplasm, Danio rerio" xref: Reactome:REACT_93638 "Transport of Mature mRNA derived from an Intron-Containing Transcript, Danio rerio" xref: Reactome:REACT_93805 "Release from the NPC and Disassembly of the mRNP, Mus musculus" xref: Reactome:REACT_94770 "Transport of Mature mRNA derived from an Intron-Containing Transcript, Mus musculus" xref: Reactome:REACT_95557 "Docking of Mature Histone mRNA complex:TAP at the NPC, Bos taurus" xref: Reactome:REACT_95729 "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex, Bos taurus" xref: Reactome:REACT_97326 "Transport of Mature Transcript to Cytoplasm, Xenopus tropicalis" xref: Reactome:REACT_97459 "Transport of Mature mRNAs Derived from Intronless Transcripts, Canis familiaris" xref: Reactome:REACT_97820 "Release from the NPC and Disassembly of the mRNP, Rattus norvegicus" xref: Reactome:REACT_98292 "Transport of Mature mRNA derived from an Intron-Containing Transcript, Canis familiaris" xref: Reactome:REACT_98338 "Transport of Mature mRNA derived from an Intron-Containing Transcript, Drosophila melanogaster" xref: Reactome:REACT_98481 "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex, Xenopus tropicalis" xref: Reactome:REACT_99883 "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC, Rattus norvegicus" is_a: GO:0006405 ! RNA export from nucleus is_a: GO:0051028 ! mRNA transport relationship: part_of GO:0010467 ! gene expression relationship: part_of GO:0071427 ! mRNA-containing ribonucleoprotein complex export from nucleus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006412 name: translation namespace: biological_process alt_id: GO:0006416 alt_id: GO:0006453 alt_id: GO:0043037 def: "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "protein anabolism" EXACT [] synonym: "protein biosynthesis" EXACT [] synonym: "protein biosynthetic process" EXACT [GOC:curators] synonym: "protein formation" EXACT [] synonym: "protein synthesis" EXACT [] synonym: "protein translation" EXACT [] xref: Reactome:REACT_100338 "Translation, Sus scrofa" xref: Reactome:REACT_100851 "Translation, Saccharomyces cerevisiae" xref: Reactome:REACT_101045 "Translation, Dictyostelium discoideum" xref: Reactome:REACT_101324 "Translation, Canis familiaris" xref: Reactome:REACT_1014 "Translation, Homo sapiens" xref: Reactome:REACT_103420 "Translation, Plasmodium falciparum" xref: Reactome:REACT_105544 "Translation, Arabidopsis thaliana" xref: Reactome:REACT_29980 "Translation, Bos taurus" xref: Reactome:REACT_33559 "Translation, Rattus norvegicus" xref: Reactome:REACT_77710 "Translation, Drosophila melanogaster" xref: Reactome:REACT_79784 "Translation, Danio rerio" xref: Reactome:REACT_81734 "Translation, Schizosaccharomyces pombe" xref: Reactome:REACT_81833 "Translation, Caenorhabditis elegans" xref: Reactome:REACT_82171 "Translation, Xenopus tropicalis" xref: Reactome:REACT_83429 "Translation, Taeniopygia guttata" xref: Reactome:REACT_83530 "Translation, Gallus gallus" xref: Reactome:REACT_86996 "Translation, Oryza sativa" xref: Reactome:REACT_95535 "Translation, Mus musculus" xref: Reactome:REACT_96394 "Translation, Escherichia coli" xref: Wikipedia:Translation_(genetics) is_a: GO:0034645 ! cellular macromolecule biosynthetic process is_a: GO:0043043 ! peptide biosynthetic process is_a: GO:0044267 ! cellular protein metabolic process relationship: has_part GO:0006414 ! translational elongation relationship: part_of GO:0010467 ! gene expression property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006413 name: translational initiation namespace: biological_process alt_id: GO:0006440 alt_id: GO:0006454 def: "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] subset: goslim_yeast subset: gosubset_prok synonym: "biopolymerisation" BROAD [] synonym: "biopolymerization" BROAD [] synonym: "protein synthesis initiation" BROAD [] synonym: "translation initiation" EXACT [] xref: Reactome:REACT_101789 "Eukaryotic Translation Initiation, Gallus gallus" xref: Reactome:REACT_104290 "Eukaryotic Translation Initiation, Xenopus tropicalis" xref: Reactome:REACT_2159 "Eukaryotic Translation Initiation, Homo sapiens" xref: Reactome:REACT_29447 "Eukaryotic Translation Initiation, Dictyostelium discoideum" xref: Reactome:REACT_30389 "Eukaryotic Translation Initiation, Oryza sativa" xref: Reactome:REACT_33969 "Eukaryotic Translation Initiation, Caenorhabditis elegans" xref: Reactome:REACT_34354 "Eukaryotic Translation Initiation, Taeniopygia guttata" xref: Reactome:REACT_77252 "Eukaryotic Translation Initiation, Drosophila melanogaster" xref: Reactome:REACT_79705 "Eukaryotic Translation Initiation, Rattus norvegicus" xref: Reactome:REACT_85780 "Eukaryotic Translation Initiation, Bos taurus" xref: Reactome:REACT_88031 "Eukaryotic Translation Initiation, Schizosaccharomyces pombe" xref: Reactome:REACT_91066 "Eukaryotic Translation Initiation, Arabidopsis thaliana" xref: Reactome:REACT_95293 "Eukaryotic Translation Initiation, Plasmodium falciparum" xref: Reactome:REACT_95552 "Eukaryotic Translation Initiation, Mus musculus" xref: Reactome:REACT_95685 "Eukaryotic Translation Initiation, Canis familiaris" xref: Reactome:REACT_97707 "Eukaryotic Translation Initiation, Sus scrofa" xref: Reactome:REACT_98138 "Eukaryotic Translation Initiation, Saccharomyces cerevisiae" xref: Reactome:REACT_99004 "Eukaryotic Translation Initiation, Danio rerio" is_a: GO:0044237 ! cellular metabolic process relationship: part_of GO:0006412 ! translation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006414 name: translational elongation namespace: biological_process alt_id: GO:0006442 alt_id: GO:0006455 def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems] subset: goslim_yeast subset: gosubset_prok synonym: "protein synthesis elongation" BROAD [] synonym: "translation elongation" EXACT [] xref: Reactome:REACT_100207 "Eukaryotic Translation Elongation, Dictyostelium discoideum" xref: Reactome:REACT_100561 "Eukaryotic Translation Elongation, Canis familiaris" xref: Reactome:REACT_101290 "Eukaryotic Translation Elongation, Gallus gallus" xref: Reactome:REACT_101737 "Eukaryotic Translation Elongation, Escherichia coli" xref: Reactome:REACT_102082 "Eukaryotic Translation Elongation, Mus musculus" xref: Reactome:REACT_103580 "Eukaryotic Translation Elongation, Danio rerio" xref: Reactome:REACT_108124 "Eukaryotic Translation Elongation, Xenopus tropicalis" xref: Reactome:REACT_108677 "Eukaryotic Translation Elongation, Taeniopygia guttata" xref: Reactome:REACT_108858 "Eukaryotic Translation Elongation, Caenorhabditis elegans" xref: Reactome:REACT_1477 "Eukaryotic Translation Elongation, Homo sapiens" xref: Reactome:REACT_30678 "Eukaryotic Translation Elongation, Arabidopsis thaliana" xref: Reactome:REACT_31079 "Eukaryotic Translation Elongation, Sus scrofa" xref: Reactome:REACT_80015 "Eukaryotic Translation Elongation, Bos taurus" xref: Reactome:REACT_80831 "Eukaryotic Translation Elongation, Rattus norvegicus" xref: Reactome:REACT_81624 "Eukaryotic Translation Elongation, Drosophila melanogaster" xref: Reactome:REACT_82124 "Eukaryotic Translation Elongation, Saccharomyces cerevisiae" xref: Reactome:REACT_88049 "Eukaryotic Translation Elongation, Schizosaccharomyces pombe" xref: Reactome:REACT_93503 "Eukaryotic Translation Elongation, Oryza sativa" xref: Reactome:REACT_96070 "Eukaryotic Translation Elongation, Plasmodium falciparum" is_a: GO:0034645 ! cellular macromolecule biosynthetic process relationship: part_of GO:0006412 ! translation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006417 name: regulation of translation namespace: biological_process alt_id: GO:0006445 def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete] subset: goslim_yeast subset: gosubset_prok synonym: "regulation of protein anabolism" EXACT [] synonym: "regulation of protein biosynthesis" EXACT [] synonym: "regulation of protein formation" EXACT [] synonym: "regulation of protein synthesis" EXACT [] is_a: GO:0010608 ! posttranscriptional regulation of gene expression is_a: GO:0032268 ! regulation of cellular protein metabolic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006412 ! translation relationship: regulates GO:0006412 ! translation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006461 name: protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex." [GOC:ai] subset: goslim_chembl subset: goslim_generic subset: goslim_pombe subset: gosubset_prok synonym: "chaperone activity" RELATED [] synonym: "protein complex formation" EXACT [] is_a: GO:0065003 ! macromolecular complex assembly is_a: GO:0071822 ! protein complex subunit organization relationship: part_of GO:0070271 ! protein complex biogenesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006464 name: cellular protein modification process namespace: biological_process def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "process resulting in protein modification" RELATED [] synonym: "protein modification process" BROAD [GOC:bf, GOC:jl] synonym: "protein tagging activity" RELATED [] is_a: GO:0036211 ! protein modification process is_a: GO:0044267 ! cellular protein metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006468 name: protein phosphorylation namespace: biological_process def: "The process of introducing a phosphate group on to a protein." [GOC:hb] subset: goslim_yeast subset: gosubset_prok synonym: "protein amino acid phosphorylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process is_a: GO:0016310 ! phosphorylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006470 name: protein dephosphorylation namespace: biological_process def: "The process of removing one or more phosphoric residues from a protein." [GOC:hb] subset: goslim_yeast subset: gosubset_prok synonym: "protein amino acid dephosphorylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process is_a: GO:0016311 ! dephosphorylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006473 name: protein acetylation namespace: biological_process def: "The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai] subset: gosubset_prok synonym: "protein amino acid acetylation" EXACT [GOC:bf] is_a: GO:0043543 ! protein acylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006475 name: internal protein amino acid acetylation namespace: biological_process def: "The addition of an acetyl group to a non-terminal amino acid in a protein." [GOC:mah] subset: gosubset_prok is_a: GO:0006473 ! protein acetylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006476 name: protein deacetylation namespace: biological_process def: "The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai] subset: gosubset_prok synonym: "protein amino acid deacetylation" EXACT [GOC:bf] is_a: GO:0035601 ! protein deacylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006479 name: protein methylation namespace: biological_process def: "The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:ai] subset: gosubset_prok synonym: "protein amino acid methylation" EXACT [GOC:bf] is_a: GO:0008213 ! protein alkylation is_a: GO:0043414 ! macromolecule methylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006486 name: protein glycosylation namespace: biological_process def: "A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr] subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "protein amino acid glycosylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process is_a: GO:0043413 ! macromolecule glycosylation is_a: GO:0044763 ! single-organism cellular process relationship: part_of GO:0009101 ! glycoprotein biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006487 name: protein N-linked glycosylation namespace: biological_process def: "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327] subset: gosubset_prok synonym: "N-glycan biosynthesis" RELATED [] synonym: "N-glycan metabolism" RELATED [] synonym: "protein amino acid N-linked glycosylation" EXACT [GOC:bf] xref: RESID:AA0151 xref: RESID:AA0156 xref: RESID:AA0327 is_a: GO:0006486 ! protein glycosylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006491 name: N-glycan processing namespace: biological_process alt_id: GO:0006492 def: "The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking." [ISBN:0879695595, PMID:12736198] subset: gosubset_prok synonym: "N-glycan catabolism" RELATED [] synonym: "N-glycan degradation" RELATED [] synonym: "N-linked glycoprotein maturation" EXACT [] is_a: GO:0009311 ! oligosaccharide metabolic process relationship: part_of GO:0006487 ! protein N-linked glycosylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006497 name: protein lipidation namespace: biological_process alt_id: GO:0042050 def: "The covalent attachment of lipid groups to an amino acid in a protein." [GOC:jl] comment: For non-covalent interactions with a lipid, consider instead the term 'lipid binding ; GO:0008289' and its children. subset: goslim_yeast subset: gosubset_prok synonym: "lipid:protein modification" EXACT [] synonym: "protein amino acid lipidation" EXACT [GOC:bf] xref: RESID:AA0059 xref: RESID:AA0060 xref: RESID:AA0077 xref: RESID:AA0078 xref: RESID:AA0079 xref: RESID:AA0080 xref: RESID:AA0102 xref: RESID:AA0103 xref: RESID:AA0104 xref: RESID:AA0106 xref: RESID:AA0107 xref: RESID:AA0158 xref: RESID:AA0159 xref: RESID:AA0160 xref: RESID:AA0161 xref: RESID:AA0162 xref: RESID:AA0163 xref: RESID:AA0166 xref: RESID:AA0223 xref: RESID:AA0290 xref: RESID:AA0307 xref: RESID:AA0308 xref: RESID:AA0309 xref: RESID:AA0316 is_a: GO:0006464 ! cellular protein modification process relationship: part_of GO:0042158 ! lipoprotein biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006508 name: proteolysis namespace: biological_process def: "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] comment: This term was intentionally placed under 'protein metabolic process ; GO:0019538' rather than 'protein catabolic process ; GO:0030163' to cover all processes centered on breaking peptide bonds, including those involved in protein processing. subset: goslim_chembl subset: goslim_pir subset: gosubset_prok synonym: "ATP-dependent proteolysis" NARROW [GOC:mah] synonym: "peptidolysis" EXACT [] xref: Reactome:REACT_105459 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Gallus gallus" xref: Reactome:REACT_106013 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Canis familiaris" xref: Reactome:REACT_106377 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Mus musculus" xref: Reactome:REACT_107219 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Danio rerio" xref: Reactome:REACT_110326 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Bos taurus" xref: Reactome:REACT_733 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Homo sapiens" xref: Reactome:REACT_84556 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Xenopus tropicalis" xref: Reactome:REACT_92566 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Sus scrofa" xref: Reactome:REACT_95969 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Taeniopygia guttata" xref: Reactome:REACT_98959 "Removal of aminoterminal propeptides from gamma-carboxylated proteins, Rattus norvegicus" xref: Wikipedia:Proteolysis is_a: GO:0019538 ! protein metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006511 name: ubiquitin-dependent protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] synonym: "ubiquitin-dependent protein breakdown" EXACT [] synonym: "ubiquitin-dependent protein catabolism" EXACT [] synonym: "ubiquitin-dependent protein degradation" EXACT [] synonym: "ubiquitin-dependent proteolysis" EXACT [] is_a: GO:0019941 ! modification-dependent protein catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006515 name: misfolded or incompletely synthesized protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins." [GOC:jl] subset: gosubset_prok synonym: "degradation of misfolded or incompletely synthesized proteins" EXACT [] synonym: "misfolded or incompletely synthesized protein breakdown" EXACT [] synonym: "misfolded or incompletely synthesized protein catabolism" EXACT [] synonym: "misfolded or incompletely synthesized protein degradation" EXACT [] is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006516 name: glycoprotein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "glycoprotein breakdown" EXACT [] synonym: "glycoprotein catabolism" EXACT [] synonym: "glycoprotein degradation" EXACT [] is_a: GO:0009100 ! glycoprotein metabolic process is_a: GO:0030163 ! protein catabolic process is_a: GO:0044265 ! cellular macromolecule catabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006518 name: peptide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [CHEBI:16670, GOC:go_curators] subset: goslim_pir subset: gosubset_prok synonym: "peptide metabolism" EXACT [] is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006520 name: cellular amino acid metabolic process namespace: biological_process alt_id: GO:0006519 def: "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732] subset: goslim_aspergillus subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "amino acid and derivative metabolism" EXACT [GOC:curators] synonym: "amino acid metabolic process" EXACT [GOC:curators] synonym: "cellular amino acid and derivative metabolic process" EXACT [] synonym: "cellular amino acid metabolism" EXACT [] xref: Reactome:REACT_116093 "Amino acid metabolism, Gallus gallus" is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0044238 ! primary metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006525 name: arginine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [CHEBI:29016, GOC:go_curators] subset: gosubset_prok synonym: "arginine metabolism" EXACT [] xref: Reactome:REACT_115912 "Arginine metabolism, Gallus gallus" xref: Wikipedia:Arginine is_a: GO:0009064 ! glutamine family amino acid metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006527 name: arginine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [CHEBI:29016, GOC:go_curators] subset: gosubset_prok synonym: "arginine breakdown" EXACT [] synonym: "arginine catabolism" EXACT [] synonym: "arginine degradation" EXACT [] is_a: GO:0006525 ! arginine metabolic process is_a: GO:0009065 ! glutamine family amino acid catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006534 name: cysteine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "cysteine metabolism" EXACT [] xref: Wikipedia:Cysteine_metabolism is_a: GO:0000096 ! sulfur amino acid metabolic process is_a: GO:0009069 ! serine family amino acid metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006560 name: proline metabolic process namespace: biological_process def: "The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] subset: gosubset_prok synonym: "proline metabolism" EXACT [] is_a: GO:0009064 ! glutamine family amino acid metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006575 name: cellular modified amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents." [CHEBI:83821, GOC:ai] subset: gosubset_prok synonym: "amino acid derivative metabolic process" EXACT [GOC:curators] synonym: "cellular amino acid derivative metabolic process" EXACT [GOC:curators] synonym: "cellular amino acid derivative metabolism" EXACT [] synonym: "cellular modified amino acid metabolism" EXACT [GOC:mah] synonym: "modified amino acid metabolic process" EXACT [GOC:mah] synonym: "modified amino acid metabolism" EXACT [GOC:mah] is_a: GO:0044237 ! cellular metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006591 name: ornithine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:jl, ISBN:0192801023] subset: gosubset_prok synonym: "ornithine metabolism" EXACT [] is_a: GO:1901605 ! alpha-amino acid metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006605 name: protein targeting namespace: biological_process def: "The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." [GOC:ma] comment: Note that protein targeting encompasses the transport of the protein to the specified location, and may also include additional steps such as protein processing. subset: goslim_chembl subset: goslim_generic subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "nascent polypeptide association" RELATED [] synonym: "protein sorting along secretory pathway" NARROW [] xref: Wikipedia:Protein_targeting is_a: GO:0006886 ! intracellular protein transport is_a: GO:1902582 ! single-organism intracellular transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006606 name: protein import into nucleus namespace: biological_process def: "The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl] synonym: "establishment of protein localization to nucleus" EXACT [GOC:mah] synonym: "protein import into cell nucleus" EXACT [] synonym: "protein nucleus import" EXACT [] synonym: "protein transport from cytoplasm to nucleus" EXACT [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0017038 ! protein import is_a: GO:0034504 ! protein localization to nucleus is_a: GO:0072594 ! establishment of protein localization to organelle is_a: GO:1902580 ! single-organism cellular localization is_a: GO:1902593 ! single-organism nuclear import relationship: part_of GO:0044744 ! protein targeting to nucleus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006611 name: protein export from nucleus namespace: biological_process alt_id: GO:0097349 def: "The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl] synonym: "copper-induced protein export from nucleus" RELATED [GOC:al] synonym: "protein export from cell nucleus" EXACT [] synonym: "protein export out of nucleus" EXACT [] synonym: "protein transport from nucleus to cytoplasm" EXACT [] synonym: "protein-nucleus export" EXACT [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0051168 ! nuclear export is_a: GO:1902582 ! single-organism intracellular transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006612 name: protein targeting to membrane namespace: biological_process def: "The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators] synonym: "protein membrane targeting" EXACT [] synonym: "protein-membrane targeting" EXACT [] is_a: GO:0006605 ! protein targeting is_a: GO:0072657 ! protein localization to membrane is_a: GO:0090150 ! establishment of protein localization to membrane property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006613 name: cotranslational protein targeting to membrane namespace: biological_process def: "The targeting of proteins to a membrane that occurs during translation. The transport of most secretory proteins, particularly those with more than 100 amino acids, into the endoplasmic reticulum lumen occurs in this manner, as does the import of some proteins into mitochondria." [ISBN:0716731363, PMID:10512867, PMID:16896215] synonym: "cotranslational membrane targeting" EXACT [] synonym: "cotranslational protein membrane targeting" EXACT [] synonym: "cotranslational protein-membrane targeting" EXACT [] is_a: GO:0006612 ! protein targeting to membrane property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006614 name: SRP-dependent cotranslational protein targeting to membrane namespace: biological_process def: "The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363] synonym: "ER translocation" BROAD [] synonym: "SRP-dependent cotranslational membrane targeting" EXACT [] synonym: "SRP-dependent cotranslational protein-membrane targeting" EXACT [] xref: Reactome:REACT_115902 "SRP-dependent cotranslational protein targeting to membrane, Homo sapiens" xref: Reactome:REACT_118153 "SRP-dependent cotranslational protein targeting to membrane, Drosophila melanogaster" xref: Reactome:REACT_118173 "SRP-dependent cotranslational protein targeting to membrane, Bos taurus" xref: Reactome:REACT_118175 "SRP-dependent cotranslational protein targeting to membrane, Plasmodium falciparum" xref: Reactome:REACT_118177 "SRP-dependent cotranslational protein targeting to membrane, Oryza sativa" xref: Reactome:REACT_118247 "SRP-dependent cotranslational protein targeting to membrane, Xenopus tropicalis" xref: Reactome:REACT_118289 "SRP-dependent cotranslational protein targeting to membrane, Schizosaccharomyces pombe" xref: Reactome:REACT_118393 "SRP-dependent cotranslational protein targeting to membrane, Mus musculus" xref: Reactome:REACT_118417 "SRP-dependent cotranslational protein targeting to membrane, Taeniopygia guttata" xref: Reactome:REACT_118424 "SRP-dependent cotranslational protein targeting to membrane, Canis familiaris" xref: Reactome:REACT_118427 "SRP-dependent cotranslational protein targeting to membrane, Dictyostelium discoideum" xref: Reactome:REACT_118436 "SRP-dependent cotranslational protein targeting to membrane, Caenorhabditis elegans" xref: Reactome:REACT_118486 "SRP-dependent cotranslational protein targeting to membrane, Saccharomyces cerevisiae" xref: Reactome:REACT_118502 "SRP-dependent cotranslational protein targeting to membrane, Arabidopsis thaliana" xref: Reactome:REACT_118521 "SRP-dependent cotranslational protein targeting to membrane, Rattus norvegicus" xref: Reactome:REACT_118548 "SRP-dependent cotranslational protein targeting to membrane, Danio rerio" xref: Reactome:REACT_118553 "SRP-dependent cotranslational protein targeting to membrane, Gallus gallus" is_a: GO:0006613 ! cotranslational protein targeting to membrane is_a: GO:0045047 ! protein targeting to ER relationship: has_part GO:0006412 ! translation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006623 name: protein targeting to vacuole namespace: biological_process def: "The process of directing proteins towards the vacuole, usually using signals contained within the protein." [GOC:curators] synonym: "protein vacuolar targeting" EXACT [] synonym: "protein-vacuolar targeting" EXACT [] synonym: "protein-vacuole targeting" EXACT [] synonym: "vacuolar protein sorting" EXACT [GOC:vw] is_a: GO:0006605 ! protein targeting is_a: GO:0007034 ! vacuolar transport is_a: GO:0016482 ! cytoplasmic transport is_a: GO:0072665 ! protein localization to vacuole is_a: GO:0072666 ! establishment of protein localization to vacuole is_a: GO:1902580 ! single-organism cellular localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006629 name: lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "lipid metabolism" EXACT [] xref: Reactome:REACT_104930 "Lipid digestion, mobilization, and transport, Drosophila melanogaster" xref: Reactome:REACT_107479 "Lipid digestion, mobilization, and transport, Xenopus tropicalis" xref: Reactome:REACT_108775 "Lipid digestion, mobilization, and transport, Canis familiaris" xref: Reactome:REACT_114669 "Lipid digestion, mobilization, and transport, Staphylococcus aureus N315" xref: Reactome:REACT_115652 "Lipid metabolism, Gallus gallus" xref: Reactome:REACT_28745 "Lipid digestion, mobilization, and transport, Saccharomyces cerevisiae" xref: Reactome:REACT_31395 "Lipid digestion, mobilization, and transport, Sus scrofa" xref: Reactome:REACT_32539 "Lipid digestion, mobilization, and transport, Bos taurus" xref: Reactome:REACT_33836 "Lipid digestion, mobilization, and transport, Rattus norvegicus" xref: Reactome:REACT_602 "Lipid digestion, mobilization, and transport, Homo sapiens" xref: Reactome:REACT_77176 "Lipid digestion, mobilization, and transport, Danio rerio" xref: Reactome:REACT_77191 "Lipid digestion, mobilization, and transport, Arabidopsis thaliana" xref: Reactome:REACT_79244 "Lipid digestion, mobilization, and transport, Plasmodium falciparum" xref: Reactome:REACT_81778 "Lipid digestion, mobilization, and transport, Oryza sativa" xref: Reactome:REACT_82512 "Lipid digestion, mobilization, and transport, Taeniopygia guttata" xref: Reactome:REACT_82723 "Lipid digestion, mobilization, and transport, Escherichia coli" xref: Reactome:REACT_87884 "Lipid digestion, mobilization, and transport, Caenorhabditis elegans" xref: Reactome:REACT_90757 "Lipid digestion, mobilization, and transport, Mus musculus" xref: Reactome:REACT_94607 "Lipid digestion, mobilization, and transport, Mycobacterium tuberculosis" xref: Reactome:REACT_97906 "Lipid digestion, mobilization, and transport, Gallus gallus" xref: Reactome:REACT_98129 "Lipid digestion, mobilization, and transport, Schizosaccharomyces pombe" xref: Reactome:REACT_99706 "Lipid digestion, mobilization, and transport, Dictyostelium discoideum" xref: Wikipedia:Lipid_metabolism is_a: GO:0044238 ! primary metabolic process is_a: GO:0044710 ! single-organism metabolic process is_a: GO:0071704 ! organic substance metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006631 name: fatty acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684] subset: gosubset_prok synonym: "fatty acid metabolism" EXACT [] xref: Reactome:REACT_32309 "CYP4A11 omega-hydroxylates laurate, Danio rerio" xref: Reactome:REACT_58734 "CYP4A11 omega-hydroxylates laurate, Bos taurus" xref: Reactome:REACT_82917 "CYP4A11 omega-hydroxylates laurate, Sus scrofa" xref: Reactome:REACT_84240 "CYP4A11 omega-hydroxylates laurate, Mus musculus" xref: Reactome:REACT_89918 "CYP4A11 omega-hydroxylates laurate, Xenopus tropicalis" xref: Reactome:REACT_92163 "CYP4A11 omega-hydroxylates laurate, Gallus gallus" xref: Reactome:REACT_98 "CYP4A11 omega-hydroxylates laurate, Homo sapiens" xref: Reactome:REACT_99726 "CYP4A11 omega-hydroxylates laurate, Canis familiaris" xref: Wikipedia:Fatty_acid_metabolism is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0044255 ! cellular lipid metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006638 name: neutral lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity." [ISBN:0198547684] subset: gosubset_prok synonym: "neutral lipid metabolism" EXACT [] is_a: GO:0044255 ! cellular lipid metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006639 name: acylglycerol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids." [ISBN:0198506732] subset: gosubset_prok synonym: "acylglycerol metabolism" EXACT [] synonym: "glyceride metabolic process" EXACT [] synonym: "glyceride metabolism" EXACT [] is_a: GO:0006638 ! neutral lipid metabolic process is_a: GO:0046486 ! glycerolipid metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006641 name: triglyceride metabolic process namespace: biological_process def: "The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins." [ISBN:0198506732] subset: gosubset_prok synonym: "triacylglycerol metabolic process" EXACT [] synonym: "triacylglycerol metabolism" EXACT [] synonym: "triglyceride metabolism" EXACT [] is_a: GO:0006639 ! acylglycerol metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006694 name: steroid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators] subset: gosubset_prok synonym: "steroid anabolism" EXACT [] synonym: "steroid biosynthesis" EXACT [] synonym: "steroid formation" EXACT [] synonym: "steroid synthesis" EXACT [] synonym: "steroidogenesis" EXACT [] xref: Wikipedia:Steroid_metabolisms#Steroid_biosynthesis is_a: GO:0008202 ! steroid metabolic process is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006696 name: ergosterol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds." [ISBN:0198506732] subset: gosubset_prok synonym: "ergosterol anabolism" EXACT [] synonym: "ergosterol biosynthesis" EXACT [] synonym: "ergosterol formation" EXACT [] synonym: "ergosterol synthesis" EXACT [] is_a: GO:0008204 ! ergosterol metabolic process is_a: GO:0016126 ! sterol biosynthetic process is_a: GO:0016129 ! phytosteroid biosynthetic process is_a: GO:0044108 ! cellular alcohol biosynthetic process is_a: GO:0097384 ! cellular lipid biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006725 name: cellular aromatic compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells." [GOC:ai, ISBN:0198506732] subset: goslim_pir subset: gosubset_prok synonym: "aromatic compound metabolism" EXACT [] synonym: "aromatic hydrocarbon metabolic process" NARROW [] synonym: "aromatic hydrocarbon metabolism" NARROW [] is_a: GO:0044237 ! cellular metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006732 name: coenzyme metabolic process namespace: biological_process alt_id: GO:0006752 def: "The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732] subset: gosubset_prok synonym: "coenzyme and prosthetic group metabolic process" BROAD [] synonym: "coenzyme and prosthetic group metabolism" BROAD [] synonym: "coenzyme metabolism" EXACT [] synonym: "group transfer coenzyme metabolic process" NARROW [] synonym: "group transfer coenzyme metabolism" NARROW [] is_a: GO:0051186 ! cofactor metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006749 name: glutathione metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [CHEBI:16856, ISBN:0198506732] subset: gosubset_prok synonym: "glutathione metabolism" EXACT [] synonym: "oxidized glutathione reduction" NARROW [] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006750 name: glutathione biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [CHEBI:16856, GOC:ai, GOC:al, GOC:pde, ISBN:0198506732] subset: gosubset_prok synonym: "glutathione anabolism" EXACT [] synonym: "glutathione biosynthesis" EXACT [] synonym: "glutathione formation" EXACT [] synonym: "glutathione synthesis" EXACT [] xref: MetaCyc:GLUTATHIONESYN-PWY xref: Reactome:REACT_103397 "Glutathione synthesis and recycling, Rattus norvegicus" xref: Reactome:REACT_105261 "Glutathione synthesis and recycling, Schizosaccharomyces pombe" xref: Reactome:REACT_110421 "Glutathione synthesis and recycling, Canis familiaris" xref: Reactome:REACT_110743 "Glutathione synthesis and recycling, Mus musculus" xref: Reactome:REACT_32911 "Glutathione synthesis and recycling, Arabidopsis thaliana" xref: Reactome:REACT_33459 "Glutathione synthesis and recycling, Sus scrofa" xref: Reactome:REACT_6960 "Glutathione synthesis and recycling, Homo sapiens" xref: Reactome:REACT_81322 "Glutathione synthesis and recycling, Danio rerio" xref: Reactome:REACT_82189 "Glutathione synthesis and recycling, Xenopus tropicalis" xref: Reactome:REACT_84374 "Glutathione synthesis and recycling, Caenorhabditis elegans" xref: Reactome:REACT_85658 "Glutathione synthesis and recycling, Saccharomyces cerevisiae" xref: Reactome:REACT_88522 "Glutathione synthesis and recycling, Bos taurus" xref: Reactome:REACT_90769 "Glutathione synthesis and recycling, Oryza sativa" xref: Reactome:REACT_92740 "Glutathione synthesis and recycling, Gallus gallus" xref: Reactome:REACT_94932 "Glutathione synthesis and recycling, Dictyostelium discoideum" xref: Reactome:REACT_96555 "Glutathione synthesis and recycling, Taeniopygia guttata" xref: Reactome:REACT_97813 "Glutathione synthesis and recycling, Plasmodium falciparum" xref: Reactome:REACT_98722 "Glutathione synthesis and recycling, Drosophila melanogaster" is_a: GO:0006749 ! glutathione metabolic process is_a: GO:0019184 ! nonribosomal peptide biosynthetic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006753 name: nucleoside phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any phosphorylated nucleoside." [GOC:mah] subset: gosubset_prok synonym: "nucleoside phosphate metabolism" EXACT [] is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006754 name: ATP biosynthetic process namespace: biological_process alt_id: GO:0006758 alt_id: GO:0006759 def: "The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "ATP anabolism" EXACT [] synonym: "ATP biosynthesis" EXACT [] synonym: "ATP formation" EXACT [] synonym: "ATP regeneration" NARROW [] synonym: "ATP synthesis" EXACT [] xref: Reactome:REACT_102219 "ADP and Pi bind to ATPase, Gallus gallus" xref: Reactome:REACT_104315 "ATP is synthesized from ADP and Pi by ATPase, Bos taurus" xref: Reactome:REACT_105384 "ATP is synthesized from ADP and Pi by ATPase, Rattus norvegicus" xref: Reactome:REACT_106830 "ATP is synthesized from ADP and Pi by ATPase, Canis familiaris" xref: Reactome:REACT_109466 "ADP and Pi bind to ATPase, Mus musculus" xref: Reactome:REACT_190 "ATP is synthesized from ADP and Pi by ATPase, Homo sapiens" xref: Reactome:REACT_28537 "ADP and Pi bind to ATPase, Sus scrofa" xref: Reactome:REACT_31626 "ADP and Pi bind to ATPase, Rattus norvegicus" xref: Reactome:REACT_33014 "ATP is synthesized from ADP and Pi by ATPase, Danio rerio" xref: Reactome:REACT_78557 "ADP and Pi bind to ATPase, Bos taurus" xref: Reactome:REACT_86305 "ATP is synthesized from ADP and Pi by ATPase, Gallus gallus" xref: Reactome:REACT_88682 "ADP and Pi bind to ATPase, Danio rerio" xref: Reactome:REACT_90150 "ADP and Pi bind to ATPase, Canis familiaris" xref: Reactome:REACT_92655 "ATP is synthesized from ADP and Pi by ATPase, Mus musculus" xref: Reactome:REACT_96844 "ATP is synthesized from ADP and Pi by ATPase, Sus scrofa" xref: Reactome:REACT_991 "ADP and Pi bind to ATPase, Homo sapiens" is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process is_a: GO:0046034 ! ATP metabolic process is_a: GO:0046129 ! purine ribonucleoside biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006790 name: sulfur compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: gosubset_prok synonym: "sulfur metabolism" EXACT [] synonym: "sulphur metabolic process" EXACT [] synonym: "sulphur metabolism" EXACT [] xref: Reactome:REACT_27247 "Sulfur compound metabolism, Mycobacterium tuberculosis" xref: Wikipedia:Sulfur_metabolism is_a: GO:0044237 ! cellular metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006793 name: phosphorus metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4)." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "phosphorus metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006796 name: phosphate-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai] subset: gosubset_prok synonym: "phosphate metabolic process" RELATED [] synonym: "phosphate metabolism" EXACT [] is_a: GO:0006793 ! phosphorus metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006801 name: superoxide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [CHEBI:18421, GOC:jl] subset: gosubset_prok synonym: "oxygen free radical metabolic process" EXACT [] synonym: "oxygen free radical metabolism" EXACT [] synonym: "superoxide free radical metabolic process" EXACT [] synonym: "superoxide free radical metabolism" EXACT [] synonym: "superoxide metabolism" EXACT [] is_a: GO:0072593 ! reactive oxygen species metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006807 name: nitrogen compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732] comment: Note that amino acid and derivative metabolism should not be annotated here. Instead use the 'amino acid and derivative metabolism' node. subset: goslim_metagenomics subset: goslim_pir subset: gosubset_prok synonym: "nitrogen compound metabolism" EXACT [] is_a: GO:0008152 ! metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006810 name: transport namespace: biological_process alt_id: GO:0015457 alt_id: GO:0015460 def: "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "auxiliary transport protein activity" RELATED [GOC:mah] synonym: "small molecule transport" NARROW [] synonym: "solute:solute exchange" NARROW [] synonym: "transport accessory protein activity" RELATED [GOC:mah] is_a: GO:0051234 ! establishment of localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006811 name: ion transport namespace: biological_process def: "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast subset: gosubset_prok xref: Reactome:REACT_102356 "Transport of inorganic cations/anions and amino acids/oligopeptides, Xenopus tropicalis" xref: Reactome:REACT_102895 "Transport of inorganic cations/anions and amino acids/oligopeptides, Staphylococcus aureus N315" xref: Reactome:REACT_106972 "Transport of inorganic cations/anions and amino acids/oligopeptides, Sus scrofa" xref: Reactome:REACT_109067 "Transport of inorganic cations/anions and amino acids/oligopeptides, Saccharomyces cerevisiae" xref: Reactome:REACT_110862 "Transport of inorganic cations/anions and amino acids/oligopeptides, Arabidopsis thaliana" xref: Reactome:REACT_19397 "Transport of inorganic cations/anions and amino acids/oligopeptides, Homo sapiens" xref: Reactome:REACT_29110 "Transport of inorganic cations/anions and amino acids/oligopeptides, Oryza sativa" xref: Reactome:REACT_31978 "Transport of inorganic cations/anions and amino acids/oligopeptides, Mus musculus" xref: Reactome:REACT_33992 "Transport of inorganic cations/anions and amino acids/oligopeptides, Danio rerio" xref: Reactome:REACT_34201 "Transport of inorganic cations/anions and amino acids/oligopeptides, Gallus gallus" xref: Reactome:REACT_79109 "Transport of inorganic cations/anions and amino acids/oligopeptides, Caenorhabditis elegans" xref: Reactome:REACT_82618 "Transport of inorganic cations/anions and amino acids/oligopeptides, Escherichia coli" xref: Reactome:REACT_87822 "Transport of inorganic cations/anions and amino acids/oligopeptides, Bos taurus" xref: Reactome:REACT_91472 "Transport of inorganic cations/anions and amino acids/oligopeptides, Dictyostelium discoideum" xref: Reactome:REACT_91958 "Transport of inorganic cations/anions and amino acids/oligopeptides, Drosophila melanogaster" xref: Reactome:REACT_92903 "Transport of inorganic cations/anions and amino acids/oligopeptides, Mycobacterium tuberculosis" xref: Reactome:REACT_93485 "Transport of inorganic cations/anions and amino acids/oligopeptides, Canis familiaris" xref: Reactome:REACT_94357 "Transport of inorganic cations/anions and amino acids/oligopeptides, Rattus norvegicus" xref: Reactome:REACT_96078 "Transport of inorganic cations/anions and amino acids/oligopeptides, Plasmodium falciparum" xref: Reactome:REACT_96919 "Transport of inorganic cations/anions and amino acids/oligopeptides, Taeniopygia guttata" xref: Reactome:REACT_98077 "Transport of inorganic cations/anions and amino acids/oligopeptides, Schizosaccharomyces pombe" is_a: GO:0044765 ! single-organism transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006812 name: cation transport namespace: biological_process alt_id: GO:0006819 alt_id: GO:0015674 def: "The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "di-, tri-valent inorganic cation transport" NARROW [GOC:mah] is_a: GO:0006811 ! ion transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006814 name: sodium ion transport namespace: biological_process alt_id: GO:0006834 alt_id: GO:0016974 def: "The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "mitochondrial sodium/calcium ion exchange" NARROW [] synonym: "sodium channel auxiliary protein activity" RELATED [GOC:mah] synonym: "sodium transport" EXACT [] synonym: "sodium/potassium transport" BROAD [] synonym: "sodium:calcium exchange" NARROW [] synonym: "sodium:solute transport" NARROW [] is_a: GO:0015672 ! monovalent inorganic cation transport is_a: GO:0030001 ! metal ion transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006818 name: hydrogen transport namespace: biological_process def: "The directed movement of hydrogen (H2 or H+), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] subset: goslim_pir subset: gosubset_prok is_a: GO:0044765 ! single-organism transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006820 name: anion transport namespace: biological_process alt_id: GO:0006822 def: "The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0006811 ! ion transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006825 name: copper ion transport namespace: biological_process def: "The directed movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0000041 ! transition metal ion transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006826 name: iron ion transport namespace: biological_process alt_id: GO:0015681 def: "The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "iron transport" EXACT [] is_a: GO:0000041 ! transition metal ion transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006835 name: dicarboxylic acid transport namespace: biological_process alt_id: GO:0006841 def: "The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok synonym: "sodium:dicarboxylate transport" RELATED [] is_a: GO:0046942 ! carboxylic acid transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006839 name: mitochondrial transport namespace: biological_process def: "Transport of substances into, out of or within a mitochondrion." [GOC:ai] synonym: "mitochondrial alpha-ketoglutarate/malate transport" NARROW [] synonym: "mitochondrial aspartate/glutamate transport" NARROW [] synonym: "mitochondrial sodium/calcium ion exchange" NARROW [] is_a: GO:1902582 ! single-organism intracellular transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006862 name: nucleotide transport namespace: biological_process def: "The directed movement of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, into, out of or within a cell." [ISBN:0198506732] subset: gosubset_prok is_a: GO:0015748 ! organophosphate ester transport is_a: GO:0015931 ! nucleobase-containing compound transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006863 name: purine nucleobase transport namespace: biological_process alt_id: GO:0015852 def: "The directed movement of purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:26386, ISBN:0198506732] subset: gosubset_prok synonym: "purine base transmembrane transport" EXACT [GOC:mah] synonym: "purine base transport" EXACT [GOC:go_curators] synonym: "purine transmembrane transport" RELATED [GOC:mah] synonym: "purine transport" RELATED [GOC:curators] is_a: GO:0015851 ! nucleobase transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006865 name: amino acid transport namespace: biological_process alt_id: GO:0006866 def: "The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir subset: goslim_yeast subset: gosubset_prok xref: Reactome:REACT_104605 "Amino acid transport across the plasma membrane, Rattus norvegicus" xref: Reactome:REACT_105142 "Amino acid transport across the plasma membrane, Mus musculus" xref: Reactome:REACT_105179 "Amino acid transport across the plasma membrane, Caenorhabditis elegans" xref: Reactome:REACT_106669 "Amino acid transport across the plasma membrane, Dictyostelium discoideum" xref: Reactome:REACT_107151 "Amino acid transport across the plasma membrane, Arabidopsis thaliana" xref: Reactome:REACT_107366 "Amino acid transport across the plasma membrane, Gallus gallus" xref: Reactome:REACT_107449 "Amino acid transport across the plasma membrane, Escherichia coli" xref: Reactome:REACT_112073 "Amino acid transport across the plasma membrane, Mycobacterium tuberculosis" xref: Reactome:REACT_115423 "Amino acid transport across the plasma membrane, Saccharomyces cerevisiae" xref: Reactome:REACT_13796 "Amino acid transport across the plasma membrane, Homo sapiens" xref: Reactome:REACT_29020 "Amino acid transport across the plasma membrane, Staphylococcus aureus N315" xref: Reactome:REACT_81602 "Amino acid transport across the plasma membrane, Oryza sativa" xref: Reactome:REACT_81848 "Amino acid transport across the plasma membrane, Danio rerio" xref: Reactome:REACT_83425 "Amino acid transport across the plasma membrane, Bos taurus" xref: Reactome:REACT_90553 "Amino acid transport across the plasma membrane, Drosophila melanogaster" xref: Reactome:REACT_95755 "Amino acid transport across the plasma membrane, Taeniopygia guttata" xref: Reactome:REACT_96944 "Amino acid transport across the plasma membrane, Sus scrofa" xref: Reactome:REACT_98408 "Amino acid transport across the plasma membrane, Xenopus tropicalis" xref: Reactome:REACT_99072 "Amino acid transport across the plasma membrane, Canis familiaris" is_a: GO:0046942 ! carboxylic acid transport is_a: GO:0071705 ! nitrogen compound transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006867 name: asparagine transport namespace: biological_process def: "The directed movement of asparagine, alpha-aminosuccinamic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "L-asparagine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015804 ! neutral amino acid transport is_a: GO:0042886 ! amide transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006868 name: glutamine transport namespace: biological_process alt_id: GO:0015815 def: "The directed movement of glutamine, 2-amino-4-carbamoylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "L-glutamine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015804 ! neutral amino acid transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006886 name: intracellular protein transport namespace: biological_process alt_id: GO:0032779 def: "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] subset: gosubset_prok synonym: "copper-induced intracellular protein transport" RELATED [GOC:al] is_a: GO:0015031 ! protein transport is_a: GO:0046907 ! intracellular transport intersection_of: GO:0015031 ! protein transport intersection_of: GO:0046907 ! intracellular transport intersection_of: occurs_in GO:0005622 ! intracellular relationship: occurs_in GO:0005622 ! intracellular relationship: part_of GO:0034613 ! cellular protein localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006887 name: exocytosis namespace: biological_process alt_id: GO:0016194 alt_id: GO:0016195 def: "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process in which most molecules are secreted from eukaryotic cells." [GOC:mah, ISBN:0716731363] subset: goslim_yeast subset: gosubset_prok synonym: "nonselective vesicle exocytosis" RELATED [] synonym: "vesicle exocytosis" EXACT [] xref: Wikipedia:Exocytosis is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0032940 ! secretion by cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006897 name: endocytosis namespace: biological_process alt_id: GO:0016193 alt_id: GO:0016196 def: "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363] subset: goslim_yeast subset: gosubset_prok synonym: "nonselective vesicle endocytosis" RELATED [] synonym: "plasma membrane invagination" EXACT [] synonym: "vesicle endocytosis" EXACT [] xref: Wikipedia:Endocytosis is_a: GO:0016192 ! vesicle-mediated transport relationship: has_part GO:0010324 ! membrane invagination property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006913 name: nucleocytoplasmic transport namespace: biological_process alt_id: GO:0000063 def: "The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators] comment: Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane, and is not traversed. subset: goslim_chembl subset: goslim_generic subset: goslim_pombe synonym: "nucleocytoplasmic shuttling" NARROW [] is_a: GO:0016482 ! cytoplasmic transport is_a: GO:0051169 ! nuclear transport relationship: occurs_in GO:0005622 ! intracellular property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006914 name: autophagy namespace: biological_process alt_id: GO:0016238 def: "The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_pombe xref: Wikipedia:Autophagy_(cellular) is_a: GO:0044248 ! cellular catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006915 name: apoptotic process namespace: biological_process alt_id: GO:0006917 alt_id: GO:0008632 def: "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] synonym: "activation of apoptosis" NARROW [] synonym: "apoptosis" NARROW [] synonym: "apoptosis activator activity" RELATED [] synonym: "apoptosis signaling" NARROW [] synonym: "apoptotic cell death" EXACT [GOC:sl] synonym: "apoptotic program" NARROW [GOC:add] synonym: "apoptotic programmed cell death" EXACT [] synonym: "cell suicide" BROAD [] synonym: "cellular suicide" BROAD [] synonym: "commitment to apoptosis" RELATED [] synonym: "induction of apoptosis" RELATED [] synonym: "induction of apoptosis by p53" RELATED [] synonym: "programmed cell death by apoptosis" EXACT [] synonym: "signaling (initiator) caspase activity" RELATED [] synonym: "type I programmed cell death" NARROW [] xref: Reactome:REACT_100045 "Apoptosis, Drosophila melanogaster" xref: Reactome:REACT_100962 "Apoptosis, Mus musculus" xref: Reactome:REACT_101249 "NRIF signals cell death from the nucleus, Danio rerio" xref: Reactome:REACT_104187 "NRAGE signals death through JNK, Taeniopygia guttata" xref: Reactome:REACT_105149 "NADE modulates death signalling, Rattus norvegicus" xref: Reactome:REACT_106405 "NRAGE signals death through JNK, Xenopus tropicalis" xref: Reactome:REACT_106672 "NADE modulates death signalling, Sus scrofa" xref: Reactome:REACT_107264 "NRIF signals cell death from the nucleus, Xenopus tropicalis" xref: Reactome:REACT_108651 "NRAGE signals death through JNK, Mus musculus" xref: Reactome:REACT_109165 "NRAGE signals death through JNK, Arabidopsis thaliana" xref: Reactome:REACT_110081 "NRAGE signals death through JNK, Schizosaccharomyces pombe" xref: Reactome:REACT_111964 "NRAGE signals death through JNK, Dictyostelium discoideum" xref: Reactome:REACT_13526 "NADE modulates death signalling, Homo sapiens" xref: Reactome:REACT_13638 "NRAGE signals death through JNK, Homo sapiens" xref: Reactome:REACT_13643 "NRIF signals cell death from the nucleus, Homo sapiens" xref: Reactome:REACT_28087 "Apoptosis, Saccharomyces cerevisiae" xref: Reactome:REACT_28795 "Apoptosis, Oryza sativa" xref: Reactome:REACT_28816 "Apoptosis, Danio rerio" xref: Reactome:REACT_30266 "Apoptosis, Arabidopsis thaliana" xref: Reactome:REACT_30361 "Apoptosis, Canis familiaris" xref: Reactome:REACT_30371 "NRAGE signals death through JNK, Saccharomyces cerevisiae" xref: Reactome:REACT_30548 "NRAGE signals death through JNK, Caenorhabditis elegans" xref: Reactome:REACT_30763 "NRAGE signals death through JNK, Oryza sativa" xref: Reactome:REACT_31349 "NRAGE signals death through JNK, Canis familiaris" xref: Reactome:REACT_34139 "NRAGE signals death through JNK, Gallus gallus" xref: Reactome:REACT_578 "Apoptosis, Homo sapiens" xref: Reactome:REACT_77132 "NRAGE signals death through JNK, Drosophila melanogaster" xref: Reactome:REACT_77313 "NADE modulates death signalling, Bos taurus" xref: Reactome:REACT_77415 "NRIF signals cell death from the nucleus, Canis familiaris" xref: Reactome:REACT_78287 "Apoptosis, Gallus gallus" xref: Reactome:REACT_78802 "NADE modulates death signalling, Canis familiaris" xref: Reactome:REACT_79809 "Apoptosis, Schizosaccharomyces pombe" xref: Reactome:REACT_82724 "Apoptosis, Taeniopygia guttata" xref: Reactome:REACT_83328 "Apoptosis, Sus scrofa" xref: Reactome:REACT_85877 "NRAGE signals death through JNK, Rattus norvegicus" xref: Reactome:REACT_86749 "Apoptosis, Rattus norvegicus" xref: Reactome:REACT_86873 "NRIF signals cell death from the nucleus, Gallus gallus" xref: Reactome:REACT_87570 "NRIF signals cell death from the nucleus, Rattus norvegicus" xref: Reactome:REACT_88740 "NRIF signals cell death from the nucleus, Sus scrofa" xref: Reactome:REACT_88784 "NRIF signals cell death from the nucleus, Mus musculus" xref: Reactome:REACT_89196 "Apoptosis, Dictyostelium discoideum" xref: Reactome:REACT_90267 "NRIF signals cell death from the nucleus, Taeniopygia guttata" xref: Reactome:REACT_91011 "Apoptosis, Caenorhabditis elegans" xref: Reactome:REACT_91243 "NADE modulates death signalling, Mus musculus" xref: Reactome:REACT_93937 "Apoptosis, Bos taurus" xref: Reactome:REACT_94099 "NRAGE signals death through JNK, Danio rerio" xref: Reactome:REACT_95069 "Apoptosis, Xenopus tropicalis" xref: Reactome:REACT_95675 "Apoptosis, Plasmodium falciparum" xref: Reactome:REACT_97627 "NRIF signals cell death from the nucleus, Bos taurus" xref: Reactome:REACT_99784 "NRAGE signals death through JNK, Bos taurus" xref: Reactome:REACT_99799 "NRAGE signals death through JNK, Sus scrofa" xref: Wikipedia:Apoptosis is_a: GO:0012501 ! programmed cell death property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006928 name: movement of cell or subcellular component namespace: biological_process def: "The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore." [GOC:dgh, GOC:dph, GOC:jl, GOC:mlg] comment: Note that in GO cellular components include whole cells (cell is_a cellular component). subset: goantislim_grouping subset: gocheck_do_not_annotate subset: goslim_pir subset: gosubset_prok synonym: "cell movement" RELATED [] synonym: "cellular component motion" EXACT [GOC:dph, GOC:jl] synonym: "cellular component movement" EXACT [] is_a: GO:0044763 ! single-organism cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006950 name: response to stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant subset: gosubset_prok synonym: "response to abiotic stress" RELATED [] synonym: "response to biotic stress" RELATED [] is_a: GO:0050896 ! response to stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006970 name: response to osmotic stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:jl] subset: goslim_yeast subset: gosubset_prok synonym: "osmotic response" EXACT [] synonym: "osmotic stress response" EXACT [] is_a: GO:0006950 ! response to stress is_a: GO:0009628 ! response to abiotic stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006971 name: hypotonic response namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell." [GOC:jl, PMID:12598593] synonym: "hypo-osmotic response" EXACT [] is_a: GO:0006970 ! response to osmotic stress property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006972 name: hyperosmotic response namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell." [GOC:jl, PMID:12142009] synonym: "HOG response" EXACT [] synonym: "hypertonic response" EXACT [] synonym: "response to hypertonicity" EXACT [GOC:mah, GOC:yaf] is_a: GO:0006970 ! response to osmotic stress property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006974 name: cellular response to DNA damage stimulus namespace: biological_process alt_id: GO:0034984 def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] subset: goslim_yeast subset: gosubset_prok synonym: "cellular DNA damage response" EXACT [] synonym: "DNA damage response" EXACT [] synonym: "response to DNA damage stimulus" BROAD [] synonym: "response to genotoxic stress" EXACT [] is_a: GO:0033554 ! cellular response to stress property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006979 name: response to oxidative stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] subset: goslim_yeast subset: gosubset_prok is_a: GO:0006950 ! response to stress property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006995 name: cellular response to nitrogen starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen." [GOC:jl] subset: gosubset_prok is_a: GO:0009267 ! cellular response to starvation is_a: GO:0043562 ! cellular response to nitrogen levels property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006996 name: organelle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_pir subset: gosubset_prok synonym: "organelle organisation" EXACT [GOC:curators] synonym: "organelle organization and biogenesis" RELATED [GOC:dph, GOC:jl, GOC:mah] is_a: GO:0016043 ! cellular component organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006997 name: nucleus organization namespace: biological_process alt_id: GO:0048287 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_pir subset: goslim_yeast synonym: "nuclear morphology" RELATED [] synonym: "nuclear organisation" EXACT [GOC:curators] synonym: "nuclear organization" EXACT [GOC:curators] synonym: "nuclear organization and biogenesis" RELATED [GOC:mah] synonym: "nucleus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0006998 name: nuclear envelope organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope." [GOC:dph, GOC:ems, GOC:jl, GOC:mah] synonym: "nuclear envelope organisation" EXACT [GOC:mah] synonym: "nuclear envelope organization and biogenesis" RELATED [GOC:mah] is_a: GO:0044802 ! single-organism membrane organization relationship: part_of GO:0006997 ! nucleus organization relationship: part_of GO:0010256 ! endomembrane system organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007000 name: nucleolus organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus." [GOC:dph, GOC:jid, GOC:jl, GOC:mah] synonym: "nucleolus organisation" EXACT [GOC:curators] synonym: "nucleolus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006997 ! nucleus organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007005 name: mitochondrion organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "mitochondria organization" EXACT [GOC:mah] synonym: "mitochondrion organisation" EXACT [GOC:mah] synonym: "mitochondrion organization and biogenesis" RELATED [GOC:curators] is_a: GO:0006996 ! organelle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007009 name: plasma membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_chembl subset: goslim_generic subset: gosubset_prok synonym: "plasma membrane organisation" EXACT [GOC:curators] synonym: "plasma membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0044802 ! single-organism membrane organization relationship: part_of GO:0010256 ! endomembrane system organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007010 name: cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "cytoskeletal organization and biogenesis" RELATED [GOC:mah] synonym: "cytoskeletal regulator activity" RELATED [] synonym: "cytoskeleton organisation" EXACT [GOC:curators] synonym: "cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007015 name: actin filament organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] synonym: "actin filament organisation" EXACT [GOC:curators] synonym: "regulation of actin filament localization" NARROW [] is_a: GO:0071822 ! protein complex subunit organization relationship: part_of GO:0030036 ! actin cytoskeleton organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007017 name: microtubule-based process namespace: biological_process def: "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] subset: goslim_chembl is_a: GO:0044763 ! single-organism cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007018 name: microtubule-based movement namespace: biological_process def: "A microtubule-based process that is mediated by motor proteins and results in the movement of organelles, other microtubules, or other particles along microtubules." [GOC:cjm, ISBN:0815316194] xref: Reactome:REACT_102513 "Axonal transport of NGF:Trk complexes, Danio rerio" xref: Reactome:REACT_113466 "Axonal transport of NGF:Trk complexes, Caenorhabditis elegans" xref: Reactome:REACT_12385 "Axonal transport of NGF:Trk complexes, Homo sapiens" xref: Reactome:REACT_25201 "Kinesins, Homo sapiens" xref: Reactome:REACT_31982 "Axonal transport of NGF:Trk complexes, Sus scrofa" xref: Reactome:REACT_32872 "Axonal transport of NGF:Trk complexes, Mus musculus" xref: Reactome:REACT_77014 "Axonal transport of NGF:Trk complexes, Drosophila melanogaster" xref: Reactome:REACT_78584 "Axonal transport of NGF:Trk complexes, Gallus gallus" xref: Reactome:REACT_87390 "Axonal transport of NGF:Trk complexes, Bos taurus" xref: Reactome:REACT_89365 "Axonal transport of NGF:Trk complexes, Taeniopygia guttata" xref: Reactome:REACT_94549 "Axonal transport of NGF:Trk complexes, Canis familiaris" xref: Reactome:REACT_95164 "Axonal transport of NGF:Trk complexes, Xenopus tropicalis" is_a: GO:0006928 ! movement of cell or subcellular component is_a: GO:0007017 ! microtubule-based process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007019 name: microtubule depolymerization namespace: biological_process def: "The removal of tubulin heterodimers from one or both ends of a microtubule." [ISBN:0815316194] synonym: "microtubule catastrophe" NARROW [GOC:dph, GOC:tb] synonym: "microtubule depolymerization during nuclear congression" NARROW [] synonym: "microtubule disassembly" EXACT [] is_a: GO:0031109 ! microtubule polymerization or depolymerization is_a: GO:0051261 ! protein depolymerization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007020 name: microtubule nucleation namespace: biological_process def: "The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation)." [GOC:go_curators, ISBN:0815316194, PMID:12517712] xref: Wikipedia:Microtubule_nucleation is_a: GO:0000226 ! microtubule cytoskeleton organization relationship: part_of GO:0046785 ! microtubule polymerization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007029 name: endoplasmic reticulum organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "endoplasmic reticulum morphology" RELATED [] synonym: "endoplasmic reticulum organisation" EXACT [GOC:curators] synonym: "endoplasmic reticulum organization and biogenesis" RELATED [GOC:mah] synonym: "ER organisation" EXACT [GOC:curators] synonym: "ER organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization relationship: part_of GO:0010256 ! endomembrane system organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007030 name: Golgi organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "Golgi organisation" EXACT [GOC:curators] synonym: "Golgi organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization relationship: part_of GO:0010256 ! endomembrane system organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007031 name: peroxisome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah] subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "peroxisome organisation" EXACT [GOC:curators] synonym: "peroxisome organization and biogenesis" RELATED [GOC:mah] synonym: "peroxisome-assembly ATPase activity" RELATED [] is_a: GO:0006996 ! organelle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007033 name: vacuole organization namespace: biological_process alt_id: GO:0044086 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole." [GOC:mah] subset: goslim_pir subset: goslim_yeast synonym: "vacuolar assembly" NARROW [GOC:mah] synonym: "vacuole biogenesis" RELATED [GOC:mah] synonym: "vacuole organisation" EXACT [GOC:curators] synonym: "vacuole organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007034 name: vacuolar transport namespace: biological_process def: "The directed movement of substances into, out of or within a vacuole." [GOC:ai] subset: goslim_chembl subset: goslim_generic is_a: GO:1902582 ! single-organism intracellular transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007039 name: protein catabolic process in the vacuole namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases." [GOC:mah, GOC:vw] synonym: "vacuolar protein breakdown" RELATED [] synonym: "vacuolar protein catabolic process" RELATED [] synonym: "vacuolar protein catabolism" RELATED [] synonym: "vacuolar protein degradation" RELATED [] is_a: GO:0044257 ! cellular protein catabolic process intersection_of: GO:0030163 ! protein catabolic process intersection_of: occurs_in GO:0005773 ! vacuole relationship: occurs_in GO:0005773 ! vacuole property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007049 name: cell cycle namespace: biological_process def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] subset: gocheck_do_not_manually_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "cell-division cycle" EXACT [] xref: Wikipedia:Cell_cycle is_a: GO:0044763 ! single-organism cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007050 name: cell cycle arrest namespace: biological_process def: "A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M)." [GOC:dph, GOC:mah, GOC:tb] synonym: "arrest of cell cycle progression" EXACT [] synonym: "cessation of cell cycle" EXACT [] synonym: "termination of cell cycle" EXACT [] xref: Reactome:REACT_104854 "Energy dependent regulation of mTOR by LKB1-AMPK, Dictyostelium discoideum" xref: Reactome:REACT_110745 "Energy dependent regulation of mTOR by LKB1-AMPK, Rattus norvegicus" xref: Reactome:REACT_21387 "Energy dependent regulation of mTOR by LKB1-AMPK, Homo sapiens" xref: Reactome:REACT_34173 "Energy dependent regulation of mTOR by LKB1-AMPK, Canis familiaris" xref: Reactome:REACT_34536 "Energy dependent regulation of mTOR by LKB1-AMPK, Gallus gallus" xref: Reactome:REACT_78416 "Energy dependent regulation of mTOR by LKB1-AMPK, Caenorhabditis elegans" xref: Reactome:REACT_78593 "Energy dependent regulation of mTOR by LKB1-AMPK, Arabidopsis thaliana" xref: Reactome:REACT_79397 "Energy dependent regulation of mTOR by LKB1-AMPK, Schizosaccharomyces pombe" xref: Reactome:REACT_80257 "Energy dependent regulation of mTOR by LKB1-AMPK, Danio rerio" xref: Reactome:REACT_80760 "Energy dependent regulation of mTOR by LKB1-AMPK, Taeniopygia guttata" xref: Reactome:REACT_81821 "Energy dependent regulation of mTOR by LKB1-AMPK, Xenopus tropicalis" xref: Reactome:REACT_84630 "Energy dependent regulation of mTOR by LKB1-AMPK, Drosophila melanogaster" xref: Reactome:REACT_86872 "Energy dependent regulation of mTOR by LKB1-AMPK, Mus musculus" xref: Reactome:REACT_90070 "Energy dependent regulation of mTOR by LKB1-AMPK, Bos taurus" xref: Reactome:REACT_90301 "Energy dependent regulation of mTOR by LKB1-AMPK, Oryza sativa" xref: Reactome:REACT_92874 "Energy dependent regulation of mTOR by LKB1-AMPK, Sus scrofa" xref: Reactome:REACT_92909 "Energy dependent regulation of mTOR by LKB1-AMPK, Saccharomyces cerevisiae" is_a: GO:0022402 ! cell cycle process is_a: GO:0045786 ! negative regulation of cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007051 name: spindle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:mah] synonym: "spindle organisation" EXACT [GOC:curators] synonym: "spindle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:0022402 ! cell cycle process is_a: GO:0071822 ! protein complex subunit organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007052 name: mitotic spindle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] synonym: "mitotic spindle organisation" EXACT [GOC:curators] synonym: "mitotic spindle organization and biogenesis" RELATED [GOC:mah] synonym: "spindle organization and biogenesis during mitosis" EXACT [] is_a: GO:0007051 ! spindle organization is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0007051 ! spindle organization intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000278 ! mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007059 name: chromosome segregation namespace: biological_process def: "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "chromosome division" EXACT [] synonym: "chromosome transmission" RELATED [] xref: Wikipedia:Chromosome_segregation is_a: GO:0044763 ! single-organism cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007062 name: sister chromatid cohesion namespace: biological_process def: "The cell cycle process in which the sister chromatids of a replicated chromosome are associated with each other." [GOC:jh, GOC:mah, ISBN:0815316194] synonym: "sister chromatid alignment" RELATED [] xref: Reactome:REACT_115472 "Phosphorylation of the SA2 Cohesin Complex, Schizosaccharomyces pombe" xref: Reactome:REACT_118229 "Phosphorylation of the SA2 Cohesin Complex, Taeniopygia guttata" xref: Reactome:REACT_118307 "Phosphorylation of the SA2 Cohesin Complex, Gallus gallus" xref: Reactome:REACT_118462 "Phosphorylation of the SA2 Cohesin Complex, Saccharomyces cerevisiae" xref: Reactome:REACT_1481 "Phosphorylation of the SA2 Cohesin Complex, Homo sapiens" xref: Reactome:REACT_30230 "Phosphorylation of the SA2 Cohesin Complex, Caenorhabditis elegans" xref: Reactome:REACT_31519 "Phosphorylation of the SA2 Cohesin Complex, Danio rerio" xref: Reactome:REACT_33003 "Phosphorylation of the SA2 Cohesin Complex, Dictyostelium discoideum" xref: Reactome:REACT_82473 "Phosphorylation of the SA2 Cohesin Complex, Canis familiaris" xref: Reactome:REACT_83187 "Phosphorylation of the SA2 Cohesin Complex, Mus musculus" xref: Reactome:REACT_84080 "Phosphorylation of the SA2 Cohesin Complex, Xenopus tropicalis" xref: Reactome:REACT_86014 "Phosphorylation of the SA2 Cohesin Complex, Bos taurus" xref: Reactome:REACT_91684 "Phosphorylation of the SA2 Cohesin Complex, Drosophila melanogaster" xref: Reactome:REACT_94817 "Phosphorylation of the SA2 Cohesin Complex, Rattus norvegicus" is_a: GO:0022402 ! cell cycle process is_a: GO:0051276 ! chromosome organization is_a: GO:1902589 ! single-organism organelle organization relationship: part_of GO:0007059 ! chromosome segregation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007064 name: mitotic sister chromatid cohesion namespace: biological_process def: "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission." [GOC:ai, GOC:rn, PMID:10827941, PMID:11389843, PMID:14623866] is_a: GO:0007062 ! sister chromatid cohesion is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0007062 ! sister chromatid cohesion intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000070 ! mitotic sister chromatid segregation relationship: part_of GO:0000278 ! mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007067 name: mitotic nuclear division namespace: biological_process def: "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] subset: goslim_chembl subset: goslim_generic synonym: "mitosis" EXACT [] xref: Wikipedia:Mitosis is_a: GO:0000280 ! nuclear division is_a: GO:1902589 ! single-organism organelle organization is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0000280 ! nuclear division intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000278 ! mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007076 name: mitotic chromosome condensation namespace: biological_process def: "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194] is_a: GO:0030261 ! chromosome condensation is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0030261 ! chromosome condensation intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000070 ! mitotic sister chromatid segregation relationship: part_of GO:0000278 ! mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007080 name: mitotic metaphase plate congression namespace: biological_process def: "The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis." [GOC:mah, ISBN:0815316194] is_a: GO:0051310 ! metaphase plate congression is_a: GO:1902580 ! single-organism cellular localization is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0051310 ! metaphase plate congression intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000070 ! mitotic sister chromatid segregation relationship: part_of GO:0000278 ! mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007088 name: regulation of mitotic nuclear division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators] synonym: "regulation of mitosis" EXACT [] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0051783 ! regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007067 ! mitotic nuclear division relationship: regulates GO:0007067 ! mitotic nuclear division property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007089 name: traversing start control point of mitotic cell cycle namespace: biological_process alt_id: GO:0000081 def: "A cell cycle process by which a cell commits to entering S phase via a positive feedback mechanism between the regulation of transcription and G1 CDK activity." [GOC:mtg_cell_cycle] is_a: GO:1900087 ! positive regulation of G1/S transition of mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007091 name: metaphase/anaphase transition of mitotic cell cycle namespace: biological_process def: "The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin." [GOC:mtg_cell_cycle, PMID:10465783] synonym: "metaphase/anaphase transition by anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process" EXACT [GOC:vw] synonym: "mitotic metaphase/anaphase transition" EXACT [] xref: Reactome:REACT_101540 "Mitotic Metaphase/Anaphase Transition, Gallus gallus" xref: Reactome:REACT_1016 "Mitotic Metaphase/Anaphase Transition, Homo sapiens" xref: Reactome:REACT_107946 "Mitotic Metaphase/Anaphase Transition, Drosophila melanogaster" xref: Reactome:REACT_109352 "Mitotic Metaphase/Anaphase Transition, Taeniopygia guttata" xref: Reactome:REACT_113057 "Mitotic Metaphase/Anaphase Transition, Schizosaccharomyces pombe" xref: Reactome:REACT_118439 "Mitotic Metaphase/Anaphase Transition, Saccharomyces cerevisiae" xref: Reactome:REACT_34753 "Mitotic Metaphase/Anaphase Transition, Bos taurus" xref: Reactome:REACT_78536 "Mitotic Metaphase/Anaphase Transition, Xenopus tropicalis" xref: Reactome:REACT_84703 "Mitotic Metaphase/Anaphase Transition, Danio rerio" xref: Reactome:REACT_85795 "Mitotic Metaphase/Anaphase Transition, Canis familiaris" xref: Reactome:REACT_88639 "Mitotic Metaphase/Anaphase Transition, Mus musculus" xref: Reactome:REACT_91559 "Mitotic Metaphase/Anaphase Transition, Rattus norvegicus" xref: Reactome:REACT_93452 "Mitotic Metaphase/Anaphase Transition, Dictyostelium discoideum" xref: Reactome:REACT_96680 "Mitotic Metaphase/Anaphase Transition, Caenorhabditis elegans" is_a: GO:0031145 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process is_a: GO:0044712 ! single-organism catabolic process is_a: GO:0044772 ! mitotic cell cycle phase transition is_a: GO:0044784 ! metaphase/anaphase transition of cell cycle intersection_of: GO:0044784 ! metaphase/anaphase transition of cell cycle intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0007067 ! mitotic nuclear division property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007093 name: mitotic cell cycle checkpoint namespace: biological_process alt_id: GO:0031575 alt_id: GO:0071780 def: "A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mtg_cell_cycle] synonym: "mitotic checkpoint" RELATED [] is_a: GO:0000075 ! cell cycle checkpoint is_a: GO:0045930 ! negative regulation of mitotic cell cycle is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0000075 ! cell cycle checkpoint intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000278 ! mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007094 name: mitotic spindle assembly checkpoint namespace: biological_process def: "A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mtg_cell_cycle, PMID:12360190] synonym: "Mad2-dependent checkpoint" NARROW [] synonym: "mitotic cell cycle spindle assembly checkpoint" EXACT [] xref: Reactome:REACT_101833 "Mitotic Spindle Checkpoint, Bos taurus" xref: Reactome:REACT_103200 "Mitotic Spindle Checkpoint, Mus musculus" xref: Reactome:REACT_106674 "Mitotic Spindle Checkpoint, Gallus gallus" xref: Reactome:REACT_2137 "Mitotic Spindle Checkpoint, Homo sapiens" xref: Reactome:REACT_30981 "Mitotic Spindle Checkpoint, Canis familiaris" xref: Reactome:REACT_32836 "Mitotic Spindle Checkpoint, Drosophila melanogaster" xref: Reactome:REACT_77438 "Mitotic Spindle Checkpoint, Taeniopygia guttata" xref: Reactome:REACT_81200 "Mitotic Spindle Checkpoint, Rattus norvegicus" xref: Reactome:REACT_82714 "Mitotic Spindle Checkpoint, Schizosaccharomyces pombe" xref: Reactome:REACT_90101 "Mitotic Spindle Checkpoint, Oryza sativa" xref: Reactome:REACT_93981 "Mitotic Spindle Checkpoint, Dictyostelium discoideum" xref: Reactome:REACT_98348 "Mitotic Spindle Checkpoint, Sus scrofa" xref: Reactome:REACT_98676 "Mitotic Spindle Checkpoint, Xenopus tropicalis" xref: Reactome:REACT_98972 "Mitotic Spindle Checkpoint, Danio rerio" xref: Reactome:REACT_99771 "Mitotic Spindle Checkpoint, Arabidopsis thaliana" is_a: GO:0051436 ! negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle is_a: GO:0071173 ! spindle assembly checkpoint is_a: GO:0071174 ! mitotic spindle checkpoint intersection_of: GO:0071173 ! spindle assembly checkpoint intersection_of: negatively_regulates GO:0090302 ! APC-Cdc20 complex activity intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: negatively_regulates GO:0090302 ! APC-Cdc20 complex activity relationship: part_of GO:0000278 ! mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007095 name: mitotic G2 DNA damage checkpoint namespace: biological_process def: "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] synonym: "mitotic cell cycle G2/M transition DNA damage checkpoint" EXACT [] is_a: GO:0031572 ! G2 DNA damage checkpoint is_a: GO:0044773 ! mitotic DNA damage checkpoint is_a: GO:0044818 ! mitotic G2/M transition checkpoint intersection_of: GO:0031572 ! G2 DNA damage checkpoint intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000278 ! mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007097 name: nuclear migration namespace: biological_process def: "The directed movement of the nucleus." [GOC:ai] synonym: "nucleus migration" EXACT [] is_a: GO:0040023 ! establishment of nucleus localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007124 name: pseudohyphal growth namespace: biological_process def: "A pattern of cell growth that occurs in conditions of nitrogen limitation and abundant fermentable carbon source. Cells become elongated, switch to a unipolar budding pattern, remain physically attached to each other, and invade the growth substrate." [GOC:krc, PMID:11104818] subset: goslim_candida subset: goslim_yeast is_a: GO:0016049 ! cell growth is_a: GO:0070783 ! growth of unicellular organism as a thread of attached cells property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007126 name: meiotic nuclear division namespace: biological_process def: "One of the two nuclear divisions that occur as part of the meiotic cell cycle." [GOC:dph, GOC:mah, PMID:9334324] subset: goslim_pombe synonym: "meiosis" BROAD [] is_a: GO:0000280 ! nuclear division is_a: GO:1902589 ! single-organism organelle organization is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0000280 ! nuclear division intersection_of: part_of GO:0051321 ! meiotic cell cycle relationship: part_of GO:0051321 ! meiotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007127 name: meiosis I namespace: biological_process def: "The first meiotic nuclear division in which homologous chromosomes are paired and segregated from each other, producing two haploid daughter nuclei." [GOC:dph, GOC:jl, GOC:mtg_cell_cycle, PMID:9334324] xref: Wikipedia:Meiosis#Meiosis_I is_a: GO:0007126 ! meiotic nuclear division relationship: ends_during GO:0007134 ! meiotic telophase I property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007128 name: meiotic prophase I namespace: biological_process def: "The cell cycle phase which is the first stage of meiosis I and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051324 ! prophase is_a: GO:0098764 ! meiosis I cell cycle phase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007129 name: synapsis namespace: biological_process def: "The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Synapsis begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete." [GOC:mtg_cell_cycle, PMID:22582262, PMID:23117617] synonym: "chromosomal pairing" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "chromosomal synapsis" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "homologous chromosome pairing at meiosis" EXACT [] xref: Wikipedia:Synapsis is_a: GO:0070192 ! chromosome organization involved in meiosis relationship: part_of GO:0007127 ! meiosis I relationship: part_of GO:0045143 ! homologous chromosome segregation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007131 name: reciprocal meiotic recombination namespace: biological_process alt_id: GO:0000021 alt_id: GO:0007145 def: "The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779] synonym: "female meiotic recombination" NARROW [] synonym: "gene conversion with reciprocal crossover" EXACT [] is_a: GO:0035825 ! reciprocal DNA recombination is_a: GO:0044710 ! single-organism metabolic process is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0007127 ! meiosis I property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007133 name: meiotic anaphase I namespace: biological_process def: "The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis I." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051322 ! anaphase is_a: GO:0098764 ! meiosis I cell cycle phase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007134 name: meiotic telophase I namespace: biological_process def: "The cell cycle phase which follows anaphase I of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051326 ! telophase is_a: GO:0098764 ! meiosis I cell cycle phase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007135 name: meiosis II namespace: biological_process def: "The second nuclear division of meiosis, in which the two chromatids in each chromosome are separated, resulting in four daughter nuclei from the two nuclei produced in meiosis II." [GOC:dph, GOC:mah, ISBN:0198547684] xref: Wikipedia:Meiosis#Meiosis_II is_a: GO:0007126 ! meiotic nuclear division property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007136 name: meiotic prophase II namespace: biological_process def: "The cell cycle phase which is the first stage of meiosis II and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051324 ! prophase is_a: GO:0098765 ! meiosis II cell cycle phase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007138 name: meiotic anaphase II namespace: biological_process def: "The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis II." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051322 ! anaphase is_a: GO:0098765 ! meiosis II cell cycle phase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007154 name: cell communication namespace: biological_process def: "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah] subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: gosubset_prok xref: Wikipedia:Cell_signaling is_a: GO:0044763 ! single-organism cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007155 name: cell adhesion namespace: biological_process def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: gosubset_prok synonym: "cell adhesion molecule activity" RELATED [] xref: Wikipedia:Cell_adhesion is_a: GO:0022610 ! biological adhesion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007157 name: heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules namespace: biological_process def: "The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732] subset: gosubset_prok synonym: "agglutination" RELATED [GOC:mah] is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007163 name: establishment or maintenance of cell polarity namespace: biological_process alt_id: GO:0030012 alt_id: GO:0030467 def: "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] subset: goslim_pombe synonym: "cell polarity" RELATED [GOC:mah, GOC:vw] synonym: "establishment and/or maintenance of cell polarity" RELATED [] synonym: "establishment and/or maintenance of cell polarization" RELATED [] is_a: GO:0044763 ! single-organism cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007165 name: signal transduction namespace: biological_process alt_id: GO:0023033 def: "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] comment: Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant subset: gosubset_prok synonym: "signaling cascade" NARROW [] synonym: "signaling pathway" RELATED [] synonym: "signalling cascade" NARROW [] synonym: "signalling pathway" RELATED [GOC:mah] xref: Reactome:REACT_100624 "EGFR interacts with phospholipase C-gamma, Gallus gallus" xref: Reactome:REACT_102354 "EGFR interacts with phospholipase C-gamma, Canis familiaris" xref: Reactome:REACT_112130 "EGFR interacts with phospholipase C-gamma, Oryza sativa" xref: Reactome:REACT_112549 "EGFR interacts with phospholipase C-gamma, Arabidopsis thaliana" xref: Reactome:REACT_113151 "EGFR interacts with phospholipase C-gamma, Mycobacterium tuberculosis" xref: Reactome:REACT_113601 "EGFR interacts with phospholipase C-gamma, Drosophila melanogaster" xref: Reactome:REACT_113964 "EGFR interacts with phospholipase C-gamma, Bos taurus" xref: Reactome:REACT_114657 "EGFR interacts with phospholipase C-gamma, Dictyostelium discoideum" xref: Reactome:REACT_114690 "EGFR interacts with phospholipase C-gamma, Saccharomyces cerevisiae" xref: Reactome:REACT_114820 "EGFR interacts with phospholipase C-gamma, Sus scrofa" xref: Reactome:REACT_114910 "EGFR interacts with phospholipase C-gamma, Caenorhabditis elegans" xref: Reactome:REACT_115037 "EGFR interacts with phospholipase C-gamma, Plasmodium falciparum" xref: Reactome:REACT_115147 "EGFR interacts with phospholipase C-gamma, Schizosaccharomyces pombe" xref: Reactome:REACT_12478 "EGFR interacts with phospholipase C-gamma, Homo sapiens" xref: Reactome:REACT_31232 "EGFR interacts with phospholipase C-gamma, Rattus norvegicus" xref: Reactome:REACT_78535 "EGFR interacts with phospholipase C-gamma, Xenopus tropicalis" xref: Reactome:REACT_89740 "EGFR interacts with phospholipase C-gamma, Taeniopygia guttata" xref: Reactome:REACT_93680 "EGFR interacts with phospholipase C-gamma, Danio rerio" xref: Reactome:REACT_98872 "EGFR interacts with phospholipase C-gamma, Mus musculus" xref: Wikipedia:Signal_transduction is_a: GO:0050794 ! regulation of cellular process relationship: part_of GO:0007154 ! cell communication relationship: part_of GO:0044700 ! single organism signaling relationship: part_of GO:0051716 ! cellular response to stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007275 name: multicellular organismal development namespace: biological_process def: "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] comment: Note that this term was 'developmental process'. subset: goslim_chembl subset: goslim_plant is_a: GO:0044707 ! single-multicellular organism process is_a: GO:0044767 ! single-organism developmental process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007329 name: positive regulation of transcription from RNA polymerase II promoter by pheromones namespace: biological_process def: "Any process involving pheromones that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:go_curators] synonym: "activation of transcription from RNA polymerase II promoter by pheromones" NARROW [] synonym: "positive regulation of transcription from Pol II promoter by pheromones" EXACT [] synonym: "stimulation of transcription from RNA polymerase II promoter by pheromones" NARROW [] synonym: "up regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] synonym: "up-regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] synonym: "upregulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] is_a: GO:0009371 ! positive regulation of transcription by pheromones is_a: GO:0046019 ! regulation of transcription from RNA polymerase II promoter by pheromones is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007346 name: regulation of mitotic cell cycle namespace: biological_process def: "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] subset: goslim_pombe synonym: "mitotic cell cycle modulation" EXACT [] synonym: "mitotic cell cycle regulation" EXACT [] synonym: "mitotic cell cycle regulator" RELATED [] synonym: "modulation of mitotic cell cycle progression" EXACT [] synonym: "regulation of mitotic cell cycle progression" EXACT [] synonym: "regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0000278 ! mitotic cell cycle relationship: regulates GO:0000278 ! mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007530 name: sex determination namespace: biological_process def: "Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732] xref: Wikipedia:Sex-determination_system is_a: GO:0003006 ! developmental process involved in reproduction property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007531 name: mating type determination namespace: biological_process def: "Any process that establishes and transmits the specification of mating type upon an individual. Mating types are the equivalent in microorganisms of the sexes in higher organisms." [http://www.biology-text.com/] is_a: GO:0007530 ! sex determination is_a: GO:0044702 ! single organism reproductive process is_a: GO:0045165 ! cell fate commitment property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007533 name: mating type switching namespace: biological_process def: "The conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus." [PMID:9928492] synonym: "mating type switching and recombination" RELATED [] is_a: GO:0007531 ! mating type determination is_a: GO:0022413 ! reproductive process in single-celled organism is_a: GO:0044710 ! single-organism metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007534 name: gene conversion at mating-type locus namespace: biological_process def: "The conversion of the mating-type locus from one allele to another resulting from the recombinational repair of a site-specific double-strand break at the mating-type locus with information from a silent donor sequence. There is no reciprocal exchange of information because the mating-type locus copies information from the donor sequence and the donor sequence remains unchanged." [GOC:elh, PMID:9928492] is_a: GO:0006312 ! mitotic recombination is_a: GO:0035822 ! gene conversion relationship: part_of GO:0007533 ! mating type switching property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0007584 name: response to nutrient namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:go_curators] subset: gosubset_prok synonym: "nutritional response pathway" NARROW [] synonym: "response to nutrients" EXACT [] is_a: GO:0031667 ! response to nutrient levels is_a: GO:0042221 ! response to chemical property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008017 name: microtubule binding namespace: molecular_function def: "Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc] synonym: "microtubule severing activity" RELATED [] synonym: "microtubule/chromatin interaction" RELATED [] is_a: GO:0015631 ! tubulin binding is_a: GO:0032403 ! protein complex binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008026 name: ATP-dependent helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] subset: gosubset_prok is_a: GO:0042623 ! ATPase activity, coupled is_a: GO:0070035 ! purine NTP-dependent helicase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008033 name: tRNA processing namespace: biological_process def: "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506] subset: goslim_yeast subset: gosubset_prok synonym: "tRNA maturation" EXACT [GOC:vw] is_a: GO:0006399 ! tRNA metabolic process is_a: GO:0034470 ! ncRNA processing property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008053 name: mitochondrial fusion namespace: biological_process def: "Merging of two or more mitochondria within a cell to form a single compartment." [PMID:11038192] is_a: GO:0007005 ! mitochondrion organization is_a: GO:0044801 ! single-organism membrane fusion is_a: GO:0048284 ! organelle fusion is_a: GO:1902589 ! single-organism organelle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008080 name: N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- is_a: GO:0016407 ! acetyltransferase activity is_a: GO:0016410 ! N-acyltransferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008081 name: phosphoric diester hydrolase activity namespace: molecular_function alt_id: GO:0004434 alt_id: GO:0016792 def: "Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators] subset: goslim_chembl subset: gosubset_prok synonym: "endonuclease VIII activity" RELATED [] synonym: "inositol or phosphatidylinositol phosphodiesterase activity" NARROW [] synonym: "inositol/phosphatidylinositol phosphodiesterase activity" NARROW [] synonym: "phosphodiesterase" NARROW [] xref: EC:3.1.4 is_a: GO:0042578 ! phosphoric ester hydrolase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008092 name: cytoskeletal protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast subset: gosubset_prok is_a: GO:0005515 ! protein binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008094 name: DNA-dependent ATPase activity namespace: molecular_function alt_id: GO:0004011 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction." [EC:3.6.1.3, GOC:jl] subset: gosubset_prok synonym: "adenosinetriphosphatase (DNA-dependent)" EXACT [] synonym: "DNA dependent ATPase activity" EXACT [] synonym: "DNA-dependent adenosinetriphosphatase activity" EXACT [] is_a: GO:0042623 ! ATPase activity, coupled property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008104 name: protein localization namespace: biological_process def: "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] subset: gosubset_prok synonym: "establishment and maintenance of protein localization" EXACT [] synonym: "protein localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008105 name: asymmetric protein localization namespace: biological_process def: "Any process in which a protein is transported to, or maintained in, a specific location such that it is distributed asymmetrically." [GOC:ma] subset: gosubset_prok synonym: "asymmetric protein localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of asymmetric protein localization" EXACT [] is_a: GO:0008104 ! protein localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008121 name: ubiquinol-cytochrome-c reductase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [EC:1.10.2.2, ISBN:0198547684] subset: gosubset_prok synonym: "coenzyme Q-cytochrome c reductase activity" EXACT [EC:1.10.2.2] synonym: "coenzyme QH2-cytochrome c reductase activity" EXACT [EC:1.10.2.2] synonym: "complex III (mitochondrial electron transport) activity" NARROW [EC:1.10.2.2] synonym: "CoQH2-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "cytochrome bc1 complex" RELATED [] synonym: "dihydrocoenzyme Q-cytochrome c reductase activity" EXACT [EC:1.10.2.2] synonym: "mitochondrial electron transport complex III" RELATED [EC:1.10.2.2] synonym: "QH2:cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "reduced coenzyme Q-cytochrome c reductase activity" EXACT [EC:1.10.2.2] synonym: "reduced ubiquinone-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "reduced ubiquinone-cytochrome c reductase, complex III (mitochondrial electron transport)" RELATED [EC:1.10.2.2] synonym: "ubihydroquinol:cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinol-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinol-cytochrome c-2 oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinol-cytochrome c1 oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinol-cytochrome c2 reductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinol:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinone--cytochrome-c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinone-cytochrome b-c1 oxidoreductase activity" EXACT [] synonym: "ubiquinone-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinone-cytochrome c reductase activity" EXACT [EC:1.10.2.2] xref: EC:1.10.2.2 xref: MetaCyc:1.10.2.2-RXN is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity is_a: GO:0016681 ! oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008131 name: primary amine oxidase activity namespace: molecular_function alt_id: GO:0004041 alt_id: GO:0008122 def: "Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide." [EC:1.4.3.21, EC:1.4.3.22, EC:1.4.3.4, MetaCyc:RXN-9597] subset: gosubset_prok synonym: "amine oxidase (copper-containing) activity" NARROW [] synonym: "amine oxidase activity" BROAD [EC:1.4.3.21] synonym: "primary-amine:oxygen oxidoreductase (deaminating) activity" EXACT systematic_synonym [EC:1.4.3.21] xref: EC:1.4.3.21 xref: KEGG:R01853 xref: MetaCyc:RXN-9597 xref: Reactome:REACT_100172 "oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC), Bos taurus" xref: Reactome:REACT_100207 "Metabolism of Noradrenaline, Danio rerio" xref: Reactome:REACT_101077 "Metabolism of Noradrenaline, Taeniopygia guttata" xref: Reactome:REACT_102408 "Dietary tyramine is oxidatively deaminated to an aldehyde by MAOB, Danio rerio" xref: Reactome:REACT_103010 "Oxidative deamination of Phenyethylamine by MAOB, Sus scrofa" xref: Reactome:REACT_103606 "oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC), Rattus norvegicus" xref: Reactome:REACT_103666 "Metabolism of Noradrenaline, Rattus norvegicus" xref: Reactome:REACT_104381 "Oxidation of 3-Methoxytyramine to homovanillic acid, Bos taurus" xref: Reactome:REACT_104729 "Metabolism of Noradrenaline, Xenopus tropicalis" xref: Reactome:REACT_105770 "Oxidative deamination of 5-Hydroxytryptamine by MAOA, Rattus norvegicus" xref: Reactome:REACT_105903 "oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC), Mycobacterium tuberculosis" xref: Reactome:REACT_106369 "Dietary tyramine is oxidatively deaminated to an aldehyde by MAOB, Rattus norvegicus" xref: Reactome:REACT_107640 "Oxidative deamination of Phenyethylamine by MAOB, Mycobacterium tuberculosis" xref: Reactome:REACT_108025 "Oxidative deamination of Phenyethylamine by MAOB, Xenopus tropicalis" xref: Reactome:REACT_108532 "Oxidation of 3-Methoxytyramine to homovanillic acid, Mus musculus" xref: Reactome:REACT_108898 "Metabolism of Noradrenaline, Canis familiaris" xref: Reactome:REACT_109487 "Oxidation of 3-Methoxytyramine to homovanillic acid, Canis familiaris" xref: Reactome:REACT_110139 "Oxidative deamination of Phenyethylamine by MAOB, Gallus gallus" xref: Reactome:REACT_112132 "Oxidative deamination of 5-Hydroxytryptamine by MAOA, Dictyostelium discoideum" xref: Reactome:REACT_112188 "oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC), Dictyostelium discoideum" xref: Reactome:REACT_112919 "Oxidative deamination of Phenyethylamine by MAOB, Dictyostelium discoideum" xref: Reactome:REACT_113622 "Dietary tyramine is oxidatively deaminated to an aldehyde by MAOB, Dictyostelium discoideum" xref: Reactome:REACT_114320 "Oxidation of 3-Methoxytyramine to homovanillic acid, Dictyostelium discoideum" xref: Reactome:REACT_115498 "Metabolism of Noradrenaline, Dictyostelium discoideum" xref: Reactome:REACT_1260 "Dietary tyramine is oxidatively deaminated to an aldehyde by MAOB, Homo sapiens" xref: Reactome:REACT_15390 "Metabolism of Noradrenaline, Homo sapiens" xref: Reactome:REACT_15434 "Oxidation of 3-Methoxytyramine to homovanillic acid, Homo sapiens" xref: Reactome:REACT_15485 "oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC), Homo sapiens" xref: Reactome:REACT_1795 "Oxidative deamination of 5-Hydroxytryptamine by MAOA, Homo sapiens" xref: Reactome:REACT_30062 "Oxidative deamination of 5-Hydroxytryptamine by MAOA, Gallus gallus" xref: Reactome:REACT_31086 "oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC), Canis familiaris" xref: Reactome:REACT_31747 "Oxidation of 3-Methoxytyramine to homovanillic acid, Rattus norvegicus" xref: Reactome:REACT_32073 "Dietary tyramine is oxidatively deaminated to an aldehyde by MAOB, Bos taurus" xref: Reactome:REACT_32275 "Oxidative deamination of 5-Hydroxytryptamine by MAOA, Canis familiaris" xref: Reactome:REACT_33881 "oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC), Sus scrofa" xref: Reactome:REACT_33889 "Oxidative deamination of Phenyethylamine by MAOB, Rattus norvegicus" xref: Reactome:REACT_57518 "Metabolism of Noradrenaline, Gallus gallus" xref: Reactome:REACT_77250 "Oxidation of 3-Methoxytyramine to homovanillic acid, Xenopus tropicalis" xref: Reactome:REACT_77459 "Dietary tyramine is oxidatively deaminated to an aldehyde by MAOB, Mycobacterium tuberculosis" xref: Reactome:REACT_78278 "Oxidation of 3-Methoxytyramine to homovanillic acid, Danio rerio" xref: Reactome:REACT_78447 "Oxidative deamination of 5-Hydroxytryptamine by MAOA, Sus scrofa" xref: Reactome:REACT_81091 "Oxidation of 3-Methoxytyramine to homovanillic acid, Mycobacterium tuberculosis" xref: Reactome:REACT_81786 "Oxidative deamination of Phenyethylamine by MAOB, Bos taurus" xref: Reactome:REACT_82325 "oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC), Danio rerio" xref: Reactome:REACT_83353 "Oxidation of 3-Methoxytyramine to homovanillic acid, Taeniopygia guttata" xref: Reactome:REACT_83430 "Oxidation of 3-Methoxytyramine to homovanillic acid, Sus scrofa" xref: Reactome:REACT_84216 "Oxidative deamination of 5-Hydroxytryptamine by MAOA, Mycobacterium tuberculosis" xref: Reactome:REACT_85119 "oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC), Taeniopygia guttata" xref: Reactome:REACT_86644 "Oxidative deamination of Phenyethylamine by MAOB, Mus musculus" xref: Reactome:REACT_87838 "Metabolism of Noradrenaline, Bos taurus" xref: Reactome:REACT_87899 "Oxidative deamination of Phenyethylamine by MAOB, Canis familiaris" xref: Reactome:REACT_89444 "Oxidative deamination of 5-Hydroxytryptamine by MAOA, Bos taurus" xref: Reactome:REACT_90506 "Metabolism of Noradrenaline, Mycobacterium tuberculosis" xref: Reactome:REACT_91406 "Dietary tyramine is oxidatively deaminated to an aldehyde by MAOB, Taeniopygia guttata" xref: Reactome:REACT_92185 "Oxidative deamination of Phenyethylamine by MAOB, Danio rerio" xref: Reactome:REACT_93202 "Oxidative deamination of 5-Hydroxytryptamine by MAOA, Xenopus tropicalis" xref: Reactome:REACT_93997 "Oxidation of 3-Methoxytyramine to homovanillic acid, Gallus gallus" xref: Reactome:REACT_94129 "Oxidative deamination of Phenyethylamine by MAOB, Taeniopygia guttata" xref: Reactome:REACT_94583 "Metabolism of Noradrenaline, Sus scrofa" xref: Reactome:REACT_95338 "oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC), Gallus gallus" xref: Reactome:REACT_96306 "Oxidative deamination of 5-Hydroxytryptamine by MAOA, Mus musculus" xref: Reactome:REACT_96849 "oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC), Xenopus tropicalis" xref: Reactome:REACT_97385 "Dietary tyramine is oxidatively deaminated to an aldehyde by MAOB, Xenopus tropicalis" xref: Reactome:REACT_980 "Oxidative deamination of Phenyethylamine by MAOB, Homo sapiens" xref: Reactome:REACT_98280 "Dietary tyramine is oxidatively deaminated to an aldehyde by MAOB, Canis familiaris" xref: Reactome:REACT_98340 "Oxidative deamination of 5-Hydroxytryptamine by MAOA, Taeniopygia guttata" xref: Reactome:REACT_98597 "oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC), Mus musculus" xref: Reactome:REACT_98940 "Dietary tyramine is oxidatively deaminated to an aldehyde by MAOB, Mus musculus" xref: Reactome:REACT_99002 "Metabolism of Noradrenaline, Mus musculus" xref: Reactome:REACT_99366 "Oxidative deamination of 5-Hydroxytryptamine by MAOA, Danio rerio" is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008137 name: NADH dehydrogenase (ubiquinone) activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] subset: gosubset_prok synonym: "coenzyme Q reductase activity" EXACT [EC:1.6.5.3] synonym: "complex 1 dehydrogenase activity" RELATED [EC:1.6.5.3] synonym: "complex I (electron transport chain) activity" RELATED [EC:1.6.5.3] synonym: "complex I (mitochondrial electron transport) activity" RELATED [EC:1.6.5.3] synonym: "complex I (NADH:Q1 oxidoreductase) activity" RELATED [EC:1.6.5.3] synonym: "dihydronicotinamide adenine dinucleotide-coenzyme Q reductase activity" EXACT [EC:1.6.5.3] synonym: "DPNH-coenzyme Q reductase activity" EXACT [EC:1.6.5.3] synonym: "DPNH-ubiquinone reductase activity" EXACT [EC:1.6.5.3] synonym: "electron transfer complex I activity" RELATED [EC:1.6.5.3] synonym: "mitochondrial electron transport complex 1 activity" NARROW [EC:1.6.5.3] synonym: "mitochondrial electron transport complex I activity" NARROW [EC:1.6.5.3] synonym: "NADH coenzyme Q1 reductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-coenzyme Q oxidoreductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-coenzyme Q reductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-CoQ oxidoreductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-CoQ reductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-Q6 oxidoreductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-ubiquinone oxidoreductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-ubiquinone reductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-ubiquinone-1 reductase activity" EXACT [EC:1.6.5.3] synonym: "NADH:ubiquinone oxidoreductase activity" EXACT [EC:1.6.5.3] synonym: "NADH:ubiquinone oxidoreductase complex activity" RELATED [EC:1.6.5.3] synonym: "reduced nicotinamide adenine dinucleotide-coenzyme Q reductase activity" EXACT [EC:1.6.5.3] synonym: "type 1 dehydrogenase activity" RELATED [EC:1.6.5.3] synonym: "ubiquinone reductase activity" EXACT [] xref: EC:1.6.5.3 xref: MetaCyc:NADH-DEHYDROG-A-RXN xref: MetaCyc:RXN0-5330 xref: Reactome:REACT_102400 "NADH enters the respiratory chain at Complex I, Gallus gallus" xref: Reactome:REACT_33391 "NADH enters the respiratory chain at Complex I, Rattus norvegicus" xref: Reactome:REACT_6310 "NADH enters the respiratory chain at Complex I, Homo sapiens" xref: Reactome:REACT_81770 "NADH enters the respiratory chain at Complex I, Canis familiaris" xref: Reactome:REACT_81943 "NADH enters the respiratory chain at Complex I, Mus musculus" xref: Reactome:REACT_84378 "NADH enters the respiratory chain at Complex I, Bos taurus" xref: Reactome:REACT_86959 "NADH enters the respiratory chain at Complex I, Danio rerio" xref: Reactome:REACT_96903 "NADH enters the respiratory chain at Complex I, Sus scrofa" xref: Reactome:REACT_98202 "NADH enters the respiratory chain at Complex I, Drosophila melanogaster" xref: RHEA:23155 is_a: GO:0050136 ! NADH dehydrogenase (quinone) activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008143 name: poly(A) binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA." [GOC:jl] synonym: "poly(A) binding, within an RNA molecule" EXACT [] synonym: "poly(rA) binding" EXACT [GOC:mah] synonym: "poly-A binding" EXACT [GOC:mah] synonym: "polyadenylate binding" EXACT [GOC:mah] is_a: GO:0070717 ! poly-purine tract binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008144 name: drug binding namespace: molecular_function def: "Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease." [GOC:jl, ISBN:0198506732] subset: goslim_pir subset: gosubset_prok is_a: GO:0005488 ! binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008150 name: biological_process namespace: biological_process alt_id: GO:0000004 alt_id: GO:0007582 def: "Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end." [GOC:go_curators, GOC:isa_complete] comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. Note that when this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "biological process" EXACT [] synonym: "physiological process" EXACT [] xref: Wikipedia:Biological_process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008152 name: metabolic process namespace: biological_process def: "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] comment: Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions. subset: gocheck_do_not_manually_annotate subset: goslim_chembl subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "metabolic process resulting in cell growth" NARROW [] synonym: "metabolism" EXACT [] synonym: "metabolism resulting in cell growth" NARROW [] xref: Wikipedia:Metabolism is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008154 name: actin polymerization or depolymerization namespace: biological_process def: "Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah] is_a: GO:0007015 ! actin filament organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008156 name: negative regulation of DNA replication namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication." [GOC:go_curators] subset: gosubset_prok synonym: "DNA replication inhibitor" RELATED [] synonym: "down regulation of DNA replication" EXACT [] synonym: "down-regulation of DNA replication" EXACT [] synonym: "downregulation of DNA replication" EXACT [] synonym: "inhibition of DNA replication" NARROW [] is_a: GO:0006275 ! regulation of DNA replication is_a: GO:0051053 ! negative regulation of DNA metabolic process is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006260 ! DNA replication relationship: negatively_regulates GO:0006260 ! DNA replication property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008168 name: methyltransferase activity namespace: molecular_function alt_id: GO:0004480 def: "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast subset: gosubset_prok synonym: "methylase" BROAD [] xref: EC:2.1.1 xref: Reactome:REACT_100745 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Bos taurus" xref: Reactome:REACT_100863 "methylation of Dopamine to form 3-Methoxytyramine, Taeniopygia guttata" xref: Reactome:REACT_100884 "methylation of Dopamine to form 3-Methoxytyramine, Xenopus tropicalis" xref: Reactome:REACT_103958 "methylation of Dopamine to form 3-Methoxytyramine, Rattus norvegicus" xref: Reactome:REACT_104757 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine, Danio rerio" xref: Reactome:REACT_105478 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine, Bos taurus" xref: Reactome:REACT_105909 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Xenopus tropicalis" xref: Reactome:REACT_106465 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Sus scrofa" xref: Reactome:REACT_107676 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Schizosaccharomyces pombe" xref: Reactome:REACT_15531 "methylation of Dopamine to form 3-Methoxytyramine, Homo sapiens" xref: Reactome:REACT_15553 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Homo sapiens" xref: Reactome:REACT_2094 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine, Homo sapiens" xref: Reactome:REACT_29020 "methylation of Dopamine to form 3-Methoxytyramine, Bos taurus" xref: Reactome:REACT_29098 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine, Canis familiaris" xref: Reactome:REACT_33644 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Mycobacterium tuberculosis" xref: Reactome:REACT_33779 "methylation of Dopamine to form 3-Methoxytyramine, Mycobacterium tuberculosis" xref: Reactome:REACT_73401 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine, Rattus norvegicus" xref: Reactome:REACT_77286 "methylation of Dopamine to form 3-Methoxytyramine, Canis familiaris" xref: Reactome:REACT_78774 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine, Mus musculus" xref: Reactome:REACT_79799 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Mus musculus" xref: Reactome:REACT_83214 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Gallus gallus" xref: Reactome:REACT_84525 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine, Taeniopygia guttata" xref: Reactome:REACT_84974 "methylation of Dopamine to form 3-Methoxytyramine, Sus scrofa" xref: Reactome:REACT_86817 "methylation of Dopamine to form 3-Methoxytyramine, Schizosaccharomyces pombe" xref: Reactome:REACT_86905 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Rattus norvegicus" xref: Reactome:REACT_87169 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Taeniopygia guttata" xref: Reactome:REACT_93379 "methylation of Dopamine to form 3-Methoxytyramine, Gallus gallus" xref: Reactome:REACT_93809 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine, Xenopus tropicalis" xref: Reactome:REACT_94274 "Methylation of 3,4-dihydroxypheylacetic acid to homovanillic acid, Canis familiaris" xref: Reactome:REACT_96444 "methylation of Dopamine to form 3-Methoxytyramine, Mus musculus" xref: Reactome:REACT_99316 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine, Gallus gallus" is_a: GO:0016741 ! transferase activity, transferring one-carbon groups relationship: part_of GO:0032259 ! methylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008170 name: N-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008168 ! methyltransferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008173 name: RNA methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah] comment: Note that the methyl donor is usually S-adenosyl-L-methionine, but there is at least one exception (see GO:0030698). subset: gosubset_prok xref: EC:2.1.1.- xref: Reactome:REACT_10002 "snRNA Cap hypermethylation, Homo sapiens" xref: Reactome:REACT_102135 "snRNA Cap hypermethylation, Danio rerio" xref: Reactome:REACT_108169 "snRNA Cap hypermethylation, Rattus norvegicus" xref: Reactome:REACT_29381 "snRNA Cap hypermethylation, Gallus gallus" xref: Reactome:REACT_54083 "snRNA Cap hypermethylation, Bos taurus" xref: Reactome:REACT_79845 "snRNA Cap hypermethylation, Xenopus tropicalis" xref: Reactome:REACT_82745 "snRNA Cap hypermethylation, Drosophila melanogaster" xref: Reactome:REACT_88858 "snRNA Cap hypermethylation, Canis familiaris" xref: Reactome:REACT_95210 "snRNA Cap hypermethylation, Mus musculus" is_a: GO:0008168 ! methyltransferase activity relationship: part_of GO:0001510 ! RNA methylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008175 name: tRNA methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule." [GOC:mah] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008173 ! RNA methyltransferase activity relationship: part_of GO:0030488 ! tRNA methylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008177 name: succinate dehydrogenase (ubiquinone) activity namespace: molecular_function alt_id: GO:0019737 def: "Catalysis of the reaction: succinate + ubiquinone = fumarate + ubiquinol." [EC:1.3.5.1, RHEA:13716] subset: gosubset_prok synonym: "complex II" RELATED [EC:1.3.5.1] synonym: "fumarate reductase complex (i.e. FRD, involved in anaerobic respiration, repressed in aerobic respiration)" RELATED [EC:1.3.5.1] synonym: "menaquinol: fumarate oxidoreductase activity" EXACT [EC:1.3.5.1] synonym: "quinol:fumarate oxidoreductase activity" EXACT [] synonym: "succinate dehydrogenase complex (i. e. SDH, involved in aerobic respiration, repressed in anaerobic respiration)" RELATED [EC:1.3.5.1] synonym: "succinate:ubiquinone oxidoreductase activity" EXACT [EC:1.3.5.1] synonym: "succinic dehydrogenase activity" BROAD [EC:1.3.5.1] xref: EC:1.3.5.1 xref: KEGG:R02164 xref: MetaCyc:SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN xref: Reactome:REACT_103505 "Transfer of electrons through the succinate dehydrogenase complex, Danio rerio" xref: Reactome:REACT_105603 "Succinate <=> Fumarate (with FAD redox reaction on enzyme), Canis familiaris" xref: Reactome:REACT_115740 "succinate + FAD <=> fumarate + FADH2, Gallus gallus" xref: Reactome:REACT_115746 "fumarate + FADH2 <=> succinate + FAD, Gallus gallus" xref: Reactome:REACT_1667 "Succinate <=> Fumarate (with FAD redox reaction on enzyme), Homo sapiens" xref: Reactome:REACT_29121 "Succinate <=> Fumarate (with FAD redox reaction on enzyme), Bos taurus" xref: Reactome:REACT_31722 "Succinate <=> Fumarate (with FAD redox reaction on enzyme), Taeniopygia guttata" xref: Reactome:REACT_32775 "Succinate <=> Fumarate (with FAD redox reaction on enzyme), Dictyostelium discoideum" xref: Reactome:REACT_61395 "Succinate <=> Fumarate (with FAD redox reaction on enzyme), Schizosaccharomyces pombe" xref: Reactome:REACT_6292 "Transfer of electrons through the bovine succinate dehydrogenase complex, Bos taurus" xref: Reactome:REACT_6360 "Transfer of electrons through the succinate dehydrogenase complex, Homo sapiens" xref: Reactome:REACT_79375 "Succinate <=> Fumarate (with FAD redox reaction on enzyme), Rattus norvegicus" xref: Reactome:REACT_80248 "Transfer of electrons through the succinate dehydrogenase complex, Schizosaccharomyces pombe" xref: Reactome:REACT_83108 "Transfer of electrons through the succinate dehydrogenase complex, Caenorhabditis elegans" xref: Reactome:REACT_84074 "Succinate <=> Fumarate (with FAD redox reaction on enzyme), Mus musculus" xref: Reactome:REACT_84221 "Transfer of electrons through the succinate dehydrogenase complex, Canis familiaris" xref: Reactome:REACT_85717 "Succinate <=> Fumarate (with FAD redox reaction on enzyme), Gallus gallus" xref: Reactome:REACT_88528 "Succinate <=> Fumarate (with FAD redox reaction on enzyme), Saccharomyces cerevisiae" xref: Reactome:REACT_88562 "Transfer of electrons through the succinate dehydrogenase complex, Saccharomyces cerevisiae" xref: Reactome:REACT_88611 "Transfer of electrons through the succinate dehydrogenase complex, Drosophila melanogaster" xref: Reactome:REACT_89112 "Succinate <=> Fumarate (with FAD redox reaction on enzyme), Danio rerio" xref: Reactome:REACT_90176 "Transfer of electrons through the succinate dehydrogenase complex, Taeniopygia guttata" xref: Reactome:REACT_92395 "Transfer of electrons through the succinate dehydrogenase complex, Mus musculus" xref: Reactome:REACT_92514 "Transfer of electrons through the succinate dehydrogenase complex, Xenopus tropicalis" xref: Reactome:REACT_97027 "Transfer of electrons through the succinate dehydrogenase complex, Rattus norvegicus" xref: Reactome:REACT_97164 "Succinate <=> Fumarate (with FAD redox reaction on enzyme), Caenorhabditis elegans" xref: Reactome:REACT_98347 "Transfer of electrons through the succinate dehydrogenase complex, Gallus gallus" xref: Reactome:REACT_99061 "Succinate <=> Fumarate (with FAD redox reaction on enzyme), Drosophila melanogaster" xref: Reactome:REACT_99184 "Succinate <=> Fumarate (with FAD redox reaction on enzyme), Xenopus tropicalis" xref: Reactome:REACT_99727 "Transfer of electrons through the succinate dehydrogenase complex, Dictyostelium discoideum" xref: RHEA:13716 is_a: GO:0000104 ! succinate dehydrogenase activity is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008194 name: UDP-glycosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783] subset: gosubset_prok xref: Reactome:REACT_103000 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP, Bos taurus" xref: Reactome:REACT_107220 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP, Taeniopygia guttata" xref: Reactome:REACT_108286 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP, Oryza sativa" xref: Reactome:REACT_108804 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP, Mus musculus" xref: Reactome:REACT_110628 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP, Arabidopsis thaliana" xref: Reactome:REACT_1240 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP, Homo sapiens" xref: Reactome:REACT_32928 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP, Dictyostelium discoideum" xref: Reactome:REACT_34344 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP, Danio rerio" xref: Reactome:REACT_80577 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP, Xenopus tropicalis" xref: Reactome:REACT_84444 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP, Rattus norvegicus" xref: Reactome:REACT_85640 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP, Gallus gallus" xref: Reactome:REACT_89402 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP, Canis familiaris" xref: Reactome:REACT_92152 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP, Sus scrofa" xref: Reactome:REACT_95814 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP, Schizosaccharomyces pombe" xref: Reactome:REACT_97586 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP, Drosophila melanogaster" is_a: GO:0016757 ! transferase activity, transferring glycosyl groups property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008202 name: steroid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [ISBN:0198547684] subset: gosubset_prok synonym: "steroid metabolism" EXACT [] xref: Reactome:REACT_100535 "Metabolism of steroid hormones and vitamins A and D, Schizosaccharomyces pombe" xref: Reactome:REACT_104514 "Metabolism of steroid hormones and vitamins A and D, Bos taurus" xref: Reactome:REACT_104993 "Metabolism of steroid hormones and vitamins A and D, Saccharomyces cerevisiae" xref: Reactome:REACT_105831 "Metabolism of steroid hormones and vitamins A and D, Dictyostelium discoideum" xref: Reactome:REACT_108650 "Metabolism of steroid hormones and vitamins A and D, Gallus gallus" xref: Reactome:REACT_109307 "Metabolism of steroid hormones and vitamins A and D, Mycobacterium tuberculosis" xref: Reactome:REACT_109504 "Metabolism of steroid hormones and vitamins A and D, Caenorhabditis elegans" xref: Reactome:REACT_110283 "Metabolism of steroid hormones and vitamins A and D, Danio rerio" xref: Reactome:REACT_11057 "Metabolism of steroid hormones and vitamins A and D, Homo sapiens" xref: Reactome:REACT_32683 "Metabolism of steroid hormones and vitamins A and D, Drosophila melanogaster" xref: Reactome:REACT_34426 "Metabolism of steroid hormones and vitamins A and D, Arabidopsis thaliana" xref: Reactome:REACT_77930 "Metabolism of steroid hormones and vitamins A and D, Canis familiaris" xref: Reactome:REACT_81781 "Metabolism of steroid hormones and vitamins A and D, Escherichia coli" xref: Reactome:REACT_85390 "Metabolism of steroid hormones and vitamins A and D, Oryza sativa" xref: Reactome:REACT_86063 "Metabolism of steroid hormones and vitamins A and D, Taeniopygia guttata" xref: Reactome:REACT_86862 "Metabolism of steroid hormones and vitamins A and D, Mus musculus" xref: Reactome:REACT_90075 "Metabolism of steroid hormones and vitamins A and D, Rattus norvegicus" xref: Reactome:REACT_93239 "Metabolism of steroid hormones and vitamins A and D, Sus scrofa" xref: Reactome:REACT_96786 "Metabolism of steroid hormones and vitamins A and D, Xenopus tropicalis" xref: Reactome:REACT_97355 "Metabolism of steroid hormones and vitamins A and D, Plasmodium falciparum" xref: Wikipedia:Steroid_metabolism is_a: GO:0006629 ! lipid metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008204 name: ergosterol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds. It is the most important of the D provitamins and is converted to vitamin D2 on irradiation with UV light." [ISBN:0198506732] subset: gosubset_prok synonym: "ergosterol metabolism" EXACT [] is_a: GO:0016125 ! sterol metabolic process is_a: GO:0016128 ! phytosteroid metabolic process is_a: GO:0044107 ! cellular alcohol metabolic process is_a: GO:0044255 ! cellular lipid metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008213 name: protein alkylation namespace: biological_process def: "The addition of an alkyl group to a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom." [GOC:ma] subset: goslim_yeast subset: gosubset_prok synonym: "protein amino acid alkylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008219 name: cell death namespace: biological_process def: "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as \"apoptotic bodies\"); and/or (3) its corpse (or its fragments) have been engulfed by an adjacent cell in vivo." [GOC:mah, GOC:mtg_apoptosis] comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term. subset: goslim_chembl subset: goslim_generic subset: goslim_plant subset: gosubset_prok synonym: "accidental cell death" RELATED [] synonym: "necrosis" RELATED [] is_a: GO:0016265 ! death is_a: GO:0044763 ! single-organism cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008233 name: peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "hydrolase, acting on peptide bonds" EXACT [] synonym: "peptide hydrolase activity" EXACT [] synonym: "protease activity" EXACT [] synonym: "proteinase activity" EXACT [] xref: EC:3.4 xref: Reactome:REACT_106748 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Rattus norvegicus" xref: Reactome:REACT_110349 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Mus musculus" xref: Reactome:REACT_13710 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Homo sapiens" xref: Reactome:REACT_19284 "Proteolytic processing of Slit, Homo sapiens" xref: Reactome:REACT_93020 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Bos taurus" xref: Reactome:REACT_99630 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6, Gallus gallus" is_a: GO:0016787 ! hydrolase activity relationship: part_of GO:0006508 ! proteolysis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008234 name: cysteine-type peptidase activity namespace: molecular_function alt_id: GO:0004220 def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] subset: gosubset_prok synonym: "cysteine protease activity" EXACT [] synonym: "thiol protease activity" EXACT [] xref: EC:3.4.-.- is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008272 name: sulfate transport namespace: biological_process alt_id: GO:0006870 def: "The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok synonym: "sulphate transport" EXACT [] is_a: GO:0015698 ! inorganic anion transport is_a: GO:0072348 ! sulfur compound transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008276 name: protein methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group (CH3-) to a protein." [GOC:jl, ISBN:0198506732] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008168 ! methyltransferase activity relationship: part_of GO:0006479 ! protein methylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008289 name: lipid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a lipid." [GOC:ai] subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok is_a: GO:0005488 ! binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008297 name: single-stranded DNA exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule." [GOC:mah] subset: gosubset_prok synonym: "single-stranded DNA specific exodeoxyribonuclease activity" RELATED [] synonym: "ssDNA-specific exodeoxyribonuclease activity" RELATED [GOC:mah] is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008301 name: DNA binding, bending namespace: molecular_function def: "The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758] subset: gosubset_prok synonym: "DNA bending activity" EXACT [] synonym: "DNA bending involving DNA binding" EXACT [] is_a: GO:0003677 ! DNA binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008318 name: protein prenyltransferase activity namespace: molecular_function alt_id: GO:0008244 def: "Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein." [GOC:mah] xref: EC:2.5.1.- is_a: GO:0004659 ! prenyltransferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008324 name: cation transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of cation from one side of the membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "transmembrane cation transporter activity" EXACT [] is_a: GO:0015075 ! ion transmembrane transporter activity relationship: part_of GO:0006812 ! cation transport relationship: part_of GO:0098655 ! cation transmembrane transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008353 name: RNA polymerase II carboxy-terminal domain kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats." [EC:2.7.11.23, GOC:mah] synonym: "[RNA-polymerase]-subunit kinase activity" BROAD [] synonym: "ATP:DNA-directed RNA polymerase phosphotransferase activity" BROAD [EC:2.7.11.23] synonym: "CTD kinase activity" EXACT [EC:2.7.11.23] synonym: "RNA polymerase subunit kinase activity" BROAD [EC:2.7.11.23] synonym: "RNA-polymerase-subunit kinase activity" BROAD [EC:2.7.11.23] synonym: "STK9" RELATED [EC:2.7.11.23] xref: EC:2.7.11.23 xref: MetaCyc:RNA-POLYMERASE-SUBUNIT-KINASE-RXN is_a: GO:0004674 ! protein serine/threonine kinase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008374 name: O-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- xref: Reactome:REACT_1049 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Homo sapiens" xref: Reactome:REACT_105946 "Decanoylation of Proghrelin by Ghrelin O-acyltransferase, Mus musculus" xref: Reactome:REACT_107115 "Decanoylation of Proghrelin by Ghrelin O-acyltransferase, Sus scrofa" xref: Reactome:REACT_110232 "Decanoylation of Proghrelin by Ghrelin O-acyltransferase, Bos taurus" xref: Reactome:REACT_19318 "Octanoylation of Proghrelin by Ghrelin O-acyltransferase, Homo sapiens" xref: Reactome:REACT_19329 "Decanoylation of Proghrelin by Ghrelin O-acyltransferase, Homo sapiens" xref: Reactome:REACT_29061 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Taeniopygia guttata" xref: Reactome:REACT_30439 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Xenopus tropicalis" xref: Reactome:REACT_31331 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Plasmodium falciparum" xref: Reactome:REACT_32115 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Arabidopsis thaliana" xref: Reactome:REACT_34533 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Oryza sativa" xref: Reactome:REACT_77281 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Dictyostelium discoideum" xref: Reactome:REACT_78185 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Caenorhabditis elegans" xref: Reactome:REACT_78639 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Saccharomyces cerevisiae" xref: Reactome:REACT_78935 "Octanoylation of Proghrelin by Ghrelin O-acyltransferase, Rattus norvegicus" xref: Reactome:REACT_79019 "Decanoylation of Proghrelin by Ghrelin O-acyltransferase, Rattus norvegicus" xref: Reactome:REACT_81373 "Decanoylation of Proghrelin by Ghrelin O-acyltransferase, Gallus gallus" xref: Reactome:REACT_84839 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Gallus gallus" xref: Reactome:REACT_85627 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Rattus norvegicus" xref: Reactome:REACT_85903 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Canis familiaris" xref: Reactome:REACT_86966 "Octanoylation of Proghrelin by Ghrelin O-acyltransferase, Mus musculus" xref: Reactome:REACT_88670 "Octanoylation of Proghrelin by Ghrelin O-acyltransferase, Sus scrofa" xref: Reactome:REACT_90799 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Sus scrofa" xref: Reactome:REACT_92055 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Bos taurus" xref: Reactome:REACT_92710 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Danio rerio" xref: Reactome:REACT_94821 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Drosophila melanogaster" xref: Reactome:REACT_95245 "Octanoylation of Proghrelin by Ghrelin O-acyltransferase, Gallus gallus" xref: Reactome:REACT_96091 "Octanoylation of Proghrelin by Ghrelin O-acyltransferase, Bos taurus" xref: Reactome:REACT_96263 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Mus musculus" xref: Reactome:REACT_97470 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH, Schizosaccharomyces pombe" is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008379 name: thioredoxin peroxidase activity namespace: molecular_function alt_id: GO:0009031 def: "Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O." [MetaCyc:RXN0-267] subset: gosubset_prok synonym: "thiol peroxidase activity" EXACT [] synonym: "TPx activity" EXACT [] synonym: "TrxPx activity" EXACT [] xref: EC:1.11.1.- xref: MetaCyc:RXN0-267 is_a: GO:0004601 ! peroxidase activity is_a: GO:0051920 ! peroxiredoxin activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008380 name: RNA splicing namespace: biological_process alt_id: GO:0006395 def: "The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah] subset: goslim_yeast subset: gosubset_prok synonym: "pre-mRNA splicing factor activity" RELATED [] xref: Reactome:REACT_107090 "mRNA Splicing, Gallus gallus" xref: Reactome:REACT_107348 "mRNA Splicing, Dictyostelium discoideum" xref: Reactome:REACT_107931 "mRNA Splicing, Caenorhabditis elegans" xref: Reactome:REACT_108122 "mRNA Splicing, Schizosaccharomyces pombe" xref: Reactome:REACT_113880 "mRNA Splicing, Taeniopygia guttata" xref: Reactome:REACT_1735 "mRNA Splicing, Homo sapiens" xref: Reactome:REACT_34200 "mRNA Splicing, Plasmodium falciparum" xref: Reactome:REACT_81581 "mRNA Splicing, Oryza sativa" xref: Reactome:REACT_82520 "mRNA Splicing, Rattus norvegicus" xref: Reactome:REACT_91201 "mRNA Splicing, Canis familiaris" xref: Reactome:REACT_94469 "mRNA Splicing, Drosophila melanogaster" xref: Reactome:REACT_96521 "mRNA Splicing, Bos taurus" xref: Reactome:REACT_97651 "mRNA Splicing, Xenopus tropicalis" xref: Reactome:REACT_98240 "mRNA Splicing, Danio rerio" xref: Reactome:REACT_98753 "mRNA Splicing, Mus musculus" xref: Reactome:REACT_98879 "mRNA Splicing, Arabidopsis thaliana" xref: Wikipedia:RNA_splicing is_a: GO:0006396 ! RNA processing property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008408 name: 3'-5' exonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai] subset: gosubset_prok synonym: "3'-5'-exonuclease activity" EXACT [] is_a: GO:0004527 ! exonuclease activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008409 name: 5'-3' exonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end." [GOC:ai] subset: gosubset_prok is_a: GO:0004527 ! exonuclease activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008420 name: CTD phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phospho-(DNA-directed RNA polymerase) + H2O = (DNA-directed RNA polymerase) + phosphate." [EC:3.1.3.16] is_a: GO:0004722 ! protein serine/threonine phosphatase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008478 name: pyridoxal kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate." [EC:2.7.1.35] subset: gosubset_prok synonym: "ATP:pyridoxal 5'-phosphotransferase activity" EXACT [EC:2.7.1.35] synonym: "pyridoxal 5-phosphate-kinase activity" EXACT [EC:2.7.1.35] synonym: "pyridoxal kinase (phosphorylating)" EXACT [EC:2.7.1.35] synonym: "pyridoxal phosphokinase activity" EXACT [EC:2.7.1.35] synonym: "pyridoxamine kinase activity" RELATED [EC:2.7.1.35] synonym: "pyridoxine kinase activity" RELATED [EC:2.7.1.35] synonym: "vitamin B(6) kinase activity" RELATED [EC:2.7.1.35] synonym: "vitamin B6 kinase activity" RELATED [EC:2.7.1.35] xref: EC:2.7.1.35 xref: MetaCyc:PYRIDOXKIN-RXN xref: Reactome:REACT_25109 "Pyridoxine is phosphorylated, Homo sapiens" xref: Reactome:REACT_25295 "PLP results from phosphorylation of pyridoxal, Homo sapiens" xref: Reactome:REACT_25323 "Pyridoxamine is phosphorylated, Homo sapiens" xref: RHEA:10227 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008608 name: attachment of spindle microtubules to kinetochore namespace: biological_process alt_id: GO:0051313 def: "The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex." [GOC:vw, PMID:10322137] synonym: "amphotelic attachment" RELATED [] synonym: "attachment of spindle microtubules to chromosome" EXACT [] synonym: "bipolar attachment" RELATED [] synonym: "kinetochore microtubule interaction" BROAD [] synonym: "kinetochore-microtubule attachment" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "kinetochore-microtubule interaction" BROAD [] synonym: "microtubule anchoring at kinetochore" EXACT [] synonym: "microtubule and chromosome interaction" BROAD [] synonym: "microtubule and kinetochore interaction" RELATED [] synonym: "microtubule capture" NARROW [] synonym: "spindle chromosome attachment" EXACT [] synonym: "spindle kinetochore attachment" EXACT [] synonym: "spindle-chromosome interaction" BROAD [] is_a: GO:0022402 ! cell cycle process is_a: GO:0034453 ! microtubule anchoring relationship: part_of GO:0098813 ! nuclear chromosome segregation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008610 name: lipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] subset: gosubset_prok synonym: "lipid anabolism" EXACT [] synonym: "lipid biosynthesis" EXACT [] synonym: "lipid formation" EXACT [] synonym: "lipid synthesis" EXACT [] synonym: "lipogenesis" EXACT [GOC:sl] is_a: GO:0006629 ! lipid metabolic process is_a: GO:0044711 ! single-organism biosynthetic process is_a: GO:1901576 ! organic substance biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008643 name: carbohydrate transport namespace: biological_process alt_id: GO:0006861 alt_id: GO:0008644 def: "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "sugar transport" NARROW [] is_a: GO:0044765 ! single-organism transport is_a: GO:0071702 ! organic substance transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008645 name: hexose transport namespace: biological_process def: "The directed movement of hexose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Hexoses are any aldoses with a chain of six carbon atoms in the molecule." [GOC:ai] subset: gosubset_prok xref: Reactome:REACT_100058 "Hexose transport, Canis familiaris" xref: Reactome:REACT_104970 "Hexose transport, Caenorhabditis elegans" xref: Reactome:REACT_110377 "Hexose transport, Saccharomyces cerevisiae" xref: Reactome:REACT_112026 "Hexose transport, Dictyostelium discoideum" xref: Reactome:REACT_112310 "Hexose transport, Mycobacterium tuberculosis" xref: Reactome:REACT_32187 "Hexose transport, Danio rerio" xref: Reactome:REACT_33190 "Hexose transport, Arabidopsis thaliana" xref: Reactome:REACT_77183 "Hexose transport, Mus musculus" xref: Reactome:REACT_77191 "Hexose transport, Sus scrofa" xref: Reactome:REACT_85468 "Hexose transport, Escherichia coli" xref: Reactome:REACT_85632 "Hexose transport, Oryza sativa" xref: Reactome:REACT_9441 "Hexose transport, Homo sapiens" xref: Reactome:REACT_94923 "Hexose transport, Plasmodium falciparum" xref: Reactome:REACT_96504 "Hexose transport, Xenopus tropicalis" xref: Reactome:REACT_96740 "Hexose transport, Drosophila melanogaster" xref: Reactome:REACT_97695 "Hexose transport, Gallus gallus" xref: Reactome:REACT_97768 "Hexose transport, Bos taurus" xref: Reactome:REACT_98325 "Hexose transport, Taeniopygia guttata" xref: Reactome:REACT_98343 "Hexose transport, Schizosaccharomyces pombe" xref: Reactome:REACT_99675 "Hexose transport, Rattus norvegicus" is_a: GO:0015749 ! monosaccharide transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008652 name: cellular amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents." [ISBN:0198506732] subset: gosubset_prok synonym: "amino acid biosynthetic process" EXACT [GOC:curators] synonym: "cellular amino acid anabolism" EXACT [] synonym: "cellular amino acid biosynthesis" EXACT [] synonym: "cellular amino acid formation" EXACT [] synonym: "cellular amino acid synthesis" EXACT [] xref: Reactome:REACT_101745 "Amino acid synthesis and interconversion (transamination), Saccharomyces cerevisiae" xref: Reactome:REACT_106399 "Amino acid synthesis and interconversion (transamination), Schizosaccharomyces pombe" xref: Reactome:REACT_108419 "Amino acid synthesis and interconversion (transamination), Bos taurus" xref: Reactome:REACT_109330 "Amino acid synthesis and interconversion (transamination), Drosophila melanogaster" xref: Reactome:REACT_110509 "Amino acid synthesis and interconversion (transamination), Oryza sativa" xref: Reactome:REACT_112051 "Amino acid synthesis and interconversion (transamination), Staphylococcus aureus N315" xref: Reactome:REACT_238 "Amino acid synthesis and interconversion (transamination), Homo sapiens" xref: Reactome:REACT_30236 "Amino acid synthesis and interconversion (transamination), Rattus norvegicus" xref: Reactome:REACT_30845 "Amino acid synthesis and interconversion (transamination), Arabidopsis thaliana" xref: Reactome:REACT_31295 "Amino acid synthesis and interconversion (transamination), Sus scrofa" xref: Reactome:REACT_33022 "Amino acid synthesis and interconversion (transamination), Caenorhabditis elegans" xref: Reactome:REACT_77237 "Amino acid synthesis and interconversion (transamination), Dictyostelium discoideum" xref: Reactome:REACT_77379 "Amino acid synthesis and interconversion (transamination), Mus musculus" xref: Reactome:REACT_77480 "Amino acid synthesis and interconversion (transamination), Canis familiaris" xref: Reactome:REACT_77498 "Amino acid synthesis and interconversion (transamination), Plasmodium falciparum" xref: Reactome:REACT_79609 "Amino acid synthesis and interconversion (transamination), Escherichia coli" xref: Reactome:REACT_83815 "Amino acid synthesis and interconversion (transamination), Danio rerio" xref: Reactome:REACT_83995 "Amino acid synthesis and interconversion (transamination), Gallus gallus" xref: Reactome:REACT_89765 "Amino acid synthesis and interconversion (transamination), Xenopus tropicalis" xref: Reactome:REACT_92648 "Amino acid synthesis and interconversion (transamination), Mycobacterium tuberculosis" xref: Reactome:REACT_95114 "Amino acid synthesis and interconversion (transamination), Taeniopygia guttata" xref: Wikipedia:Amino_acid_synthesis is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008757 name: S-adenosylmethionine-dependent methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah] subset: gosubset_prok synonym: "S-adenosyl methionine-dependent methyltransferase activity" EXACT [] synonym: "SAM-dependent methyltransferase activity" EXACT [] is_a: GO:0008168 ! methyltransferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008796 name: bis(5'-nucleosyl)-tetraphosphatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of P(1),P(4)-bis(5'-nucleosyl)tetraphosphate into two nucleotides." [GOC:ai] subset: gosubset_prok xref: EC:3.6.1.- is_a: GO:0004551 ! nucleotide diphosphatase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008821 name: crossover junction endodeoxyribonuclease activity namespace: molecular_function alt_id: GO:0008844 def: "Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction)." [EC:3.1.22.4] synonym: "crossover junction endoribonuclease activity" EXACT [] synonym: "cruciform-cutting endonuclease activity" EXACT [EC:3.1.22.-] synonym: "endo X3" RELATED [EC:3.1.22.4] synonym: "Endo X3 activity" NARROW [EC:3.1.22.-] synonym: "endodeoxyribonuclease RUS activity" EXACT [] synonym: "endonuclease RuvC activity" NARROW [EC:3.1.22.-] synonym: "endonuclease VII activity" NARROW [EC:3.1.22.-] synonym: "endonuclease X3 activity" NARROW [EC:3.1.22.-] synonym: "Hje endonuclease activity" EXACT [EC:3.1.22.-] synonym: "Holliday junction endonuclease CCE1 activity" NARROW [EC:3.1.22.-] synonym: "Holliday junction nuclease activity" EXACT [EC:3.1.22.-] synonym: "Holliday junction resolvase activity" NARROW [EC:3.1.22.-] synonym: "Holliday junction-cleaving endonuclease activity" EXACT [EC:3.1.22.-] synonym: "Holliday junction-resolving endoribonuclease activity" NARROW [EC:3.1.22.-] synonym: "resolving enzyme CCE1 activity" NARROW [EC:3.1.22.-] synonym: "RusA endonuclease activity" NARROW [EC:3.1.22.-] synonym: "RusA holliday junction resolvase" NARROW [EC:3.1.22.4] synonym: "RusA Holliday junction resolvase activity" NARROW [EC:3.1.22.-] synonym: "RuvC endonuclease activity" NARROW [EC:3.1.22.-] synonym: "SpCCe1 holliday junction resolvase" NARROW [EC:3.1.22.4] synonym: "SpCCe1 Holliday junction resolvase activity" NARROW [EC:3.1.22.-] xref: EC:3.1.22.4 xref: MetaCyc:3.1.22.4-RXN is_a: GO:0016889 ! endodeoxyribonuclease activity, producing 3'-phosphomonoesters property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0008888 name: glycerol dehydrogenase [NAD+] activity namespace: molecular_function def: "Catalysis of the reaction: glycerol + NAD(+) = glycerone + H(+) + NADH." [EC:1.1.1.6, RHEA:13772] subset: gosubset_prok synonym: "glycerol dehydrogenase activity" BROAD [] synonym: "NAD-linked glycerol dehydrogenase activity" EXACT [EC:1.1.1.6] xref: EC:1.1.1.6 xref: KEGG:R01034 xref: MetaCyc:GLYCDEH-RXN xref: RHEA:13772 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009019 name: tRNA (guanine-N1-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine." [EC:2.1.1.31] subset: gosubset_prok synonym: "S-adenosyl-L-methionine:tRNA (guanine-1-N-)-methyltransferase activity" EXACT [EC:2.1.1.31] synonym: "S-adenosyl-L-methionine:tRNA (guanine-N1-)-methyltransferase activity" EXACT [EC:2.1.1.31] synonym: "transfer ribonucleate guanine 1-methyltransferase activity" EXACT [EC:2.1.1.31] synonym: "tRNA guanine 1-methyltransferase activity" EXACT [EC:2.1.1.31] xref: EC:2.1.1.- is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009039 name: urease activity namespace: molecular_function def: "Catalysis of the reaction: urea + H2O = CO2 + 2 NH3." [EC:3.5.1.5] subset: gosubset_prok synonym: "urea amidohydrolase activity" EXACT [EC:3.5.1.5] xref: EC:3.5.1.5 xref: MetaCyc:UREASE-RXN xref: RHEA:25346 xref: UM-BBD_reactionID:r0120 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009055 name: electron carrier activity namespace: molecular_function alt_id: GO:0009053 alt_id: GO:0009054 def: "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] subset: goslim_pir subset: gosubset_prok synonym: "2Fe-2S electron transfer carrier" NARROW [] synonym: "3Fe-4S/4Fe-4S electron transfer carrier" NARROW [] synonym: "adrenodoxin-type ferredoxin" NARROW [] synonym: "amicyanin" NARROW [] synonym: "azurin" NARROW [] synonym: "bacterial-type ferredoxin" NARROW [] synonym: "chloroplast-type ferredoxin" NARROW [] synonym: "copper electron carrier" NARROW [] synonym: "dicluster bacterial-type ferredoxin" NARROW [] synonym: "electron acceptor activity" NARROW [] synonym: "electron carrier, chlorophyll electron transport system" RELATED [] synonym: "electron donor activity" NARROW [] synonym: "electron transfer flavoprotein" NARROW [] synonym: "electron transfer flavoprotein, group I" NARROW [] synonym: "electron transfer flavoprotein, group II" NARROW [] synonym: "electron transporter activity" EXACT [] synonym: "high-potential iron-sulfur carrier" NARROW [] synonym: "iron-sulfur electron transfer carrier" NARROW [] synonym: "monocluster bacterial-type ferredoxin" NARROW [] synonym: "mononuclear iron electron carrier" NARROW [] synonym: "polyferredoxin" NARROW [] synonym: "redox-active disulfide bond electron carrier" NARROW [] synonym: "rubredoxin" NARROW [] synonym: "small blue copper electron carrier" NARROW [] synonym: "thioredoxin-like 2Fe-2S ferredoxin" NARROW [] xref: Reactome:REACT_100606 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Caenorhabditis elegans" xref: Reactome:REACT_107372 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Xenopus tropicalis" xref: Reactome:REACT_107740 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Mus musculus" xref: Reactome:REACT_107845 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Rattus norvegicus" xref: Reactome:REACT_108215 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Saccharomyces cerevisiae" xref: Reactome:REACT_109222 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Danio rerio" xref: Reactome:REACT_28440 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Escherichia coli" xref: Reactome:REACT_29712 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Bos taurus" xref: Reactome:REACT_31774 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Dictyostelium discoideum" xref: Reactome:REACT_6154 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Homo sapiens" xref: Reactome:REACT_78399 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Sus scrofa" xref: Reactome:REACT_81671 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Arabidopsis thaliana" xref: Reactome:REACT_89868 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Taeniopygia guttata" xref: Reactome:REACT_94498 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Drosophila melanogaster" xref: Reactome:REACT_98413 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Canis familiaris" xref: Reactome:REACT_98930 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Schizosaccharomyces pombe" xref: Reactome:REACT_99683 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Mycobacterium tuberculosis" xref: Reactome:REACT_99848 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF, Oryza sativa" is_a: GO:0003674 ! molecular_function property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009056 name: catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant subset: gosubset_prok synonym: "breakdown" EXACT [] synonym: "catabolism" EXACT [] synonym: "degradation" EXACT [] xref: Wikipedia:Catabolism is_a: GO:0008152 ! metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009057 name: macromolecule catabolic process namespace: biological_process alt_id: GO:0043285 def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [CHEBI:33694, GOC:mah] subset: gosubset_prok synonym: "biopolymer catabolic process" EXACT [GOC:mtg_chebi_dec09] synonym: "macromolecule breakdown" EXACT [] synonym: "macromolecule catabolism" EXACT [] synonym: "macromolecule degradation" EXACT [] is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:1901575 ! organic substance catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009058 name: biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant subset: gosubset_prok synonym: "anabolism" EXACT [] synonym: "biosynthesis" EXACT [] synonym: "formation" EXACT [] synonym: "synthesis" EXACT [] xref: Wikipedia:Anabolism is_a: GO:0008152 ! metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009059 name: macromolecule biosynthetic process namespace: biological_process alt_id: GO:0043284 def: "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [CHEBI:33694, GOC:mah] subset: gosubset_prok synonym: "biopolymer biosynthetic process" EXACT [GOC:mtg_chebi_dec09] synonym: "macromolecule anabolism" EXACT [] synonym: "macromolecule biosynthesis" EXACT [] synonym: "macromolecule formation" EXACT [] synonym: "macromolecule synthesis" EXACT [] is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:1901576 ! organic substance biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009063 name: cellular amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai] subset: gosubset_prok synonym: "amino acid catabolic process" EXACT [GOC:curators] synonym: "cellular amino acid breakdown" EXACT [] synonym: "cellular amino acid catabolism" EXACT [] synonym: "cellular amino acid degradation" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0046395 ! carboxylic acid catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009064 name: glutamine family amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai] subset: gosubset_prok synonym: "glutamine family amino acid metabolism" EXACT [] is_a: GO:1901605 ! alpha-amino acid metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009065 name: glutamine family amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai] subset: gosubset_prok synonym: "glutamine family amino acid breakdown" EXACT [] synonym: "glutamine family amino acid catabolism" EXACT [] synonym: "glutamine family amino acid degradation" EXACT [] is_a: GO:0009064 ! glutamine family amino acid metabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009069 name: serine family amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai] subset: gosubset_prok synonym: "serine family amino acid metabolism" EXACT [] is_a: GO:1901605 ! alpha-amino acid metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009070 name: serine family amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai] subset: gosubset_prok synonym: "serine family amino acid anabolism" EXACT [] synonym: "serine family amino acid biosynthesis" EXACT [] synonym: "serine family amino acid formation" EXACT [] synonym: "serine family amino acid synthesis" EXACT [] is_a: GO:0009069 ! serine family amino acid metabolic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009100 name: glycoprotein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "glycoprotein metabolism" EXACT [] is_a: GO:0019538 ! protein metabolic process is_a: GO:0044260 ! cellular macromolecule metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009101 name: glycoprotein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "glycoprotein anabolism" EXACT [] synonym: "glycoprotein biosynthesis" EXACT [] synonym: "glycoprotein formation" EXACT [] synonym: "glycoprotein synthesis" EXACT [] is_a: GO:0009100 ! glycoprotein metabolic process is_a: GO:0034645 ! cellular macromolecule biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009108 name: coenzyme biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai] subset: gosubset_prok synonym: "coenzyme anabolism" EXACT [] synonym: "coenzyme and prosthetic group biosynthesis" BROAD [] synonym: "coenzyme and prosthetic group biosynthetic process" BROAD [] synonym: "coenzyme biosynthesis" EXACT [] synonym: "coenzyme formation" EXACT [] synonym: "coenzyme synthesis" EXACT [] xref: Reactome:REACT_102165 "Coenzyme A biosynthesis, Danio rerio" xref: Reactome:REACT_104949 "Coenzyme A biosynthesis, Staphylococcus aureus N315" xref: Reactome:REACT_107153 "Coenzyme A biosynthesis, Caenorhabditis elegans" xref: Reactome:REACT_110132 "Coenzyme A biosynthesis, Escherichia coli" xref: Reactome:REACT_11218 "Coenzyme A biosynthesis, Homo sapiens" xref: Reactome:REACT_29910 "Coenzyme A biosynthesis, Xenopus tropicalis" xref: Reactome:REACT_31159 "Coenzyme A biosynthesis, Mycobacterium tuberculosis" xref: Reactome:REACT_31595 "Coenzyme A biosynthesis, Dictyostelium discoideum" xref: Reactome:REACT_32424 "Coenzyme A biosynthesis, Bos taurus" xref: Reactome:REACT_32705 "Coenzyme A biosynthesis, Saccharomyces cerevisiae" xref: Reactome:REACT_79517 "Coenzyme A biosynthesis, Mus musculus" xref: Reactome:REACT_84587 "Coenzyme A biosynthesis, Plasmodium falciparum" xref: Reactome:REACT_87576 "Coenzyme A biosynthesis, Gallus gallus" xref: Reactome:REACT_89074 "Coenzyme A biosynthesis, Arabidopsis thaliana" xref: Reactome:REACT_90447 "Coenzyme A biosynthesis, Sus scrofa" xref: Reactome:REACT_96160 "Coenzyme A biosynthesis, Canis familiaris" xref: Reactome:REACT_96658 "Coenzyme A biosynthesis, Rattus norvegicus" xref: Reactome:REACT_97175 "Coenzyme A biosynthesis, Schizosaccharomyces pombe" xref: Reactome:REACT_98290 "Coenzyme A biosynthesis, Drosophila melanogaster" xref: Reactome:REACT_98603 "Coenzyme A biosynthesis, Taeniopygia guttata" xref: Reactome:REACT_99961 "Coenzyme A biosynthesis, Oryza sativa" is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0051188 ! cofactor biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009116 name: nucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma] subset: goslim_pir subset: gosubset_prok synonym: "nucleoside metabolism" EXACT [] is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process is_a: GO:1901657 ! glycosyl compound metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009117 name: nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma] subset: goslim_metagenomics subset: goslim_pir subset: gosubset_prok synonym: "nucleotide metabolism" EXACT [] is_a: GO:0006753 ! nucleoside phosphate metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009119 name: ribonucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [CHEBI:18254, GOC:jl] subset: gosubset_prok synonym: "ribonucleoside metabolism" EXACT [] is_a: GO:0009116 ! nucleoside metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009123 name: nucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "nucleoside monophosphate metabolism" EXACT [] is_a: GO:0006753 ! nucleoside phosphate metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009124 name: nucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "nucleoside monophosphate anabolism" EXACT [] synonym: "nucleoside monophosphate biosynthesis" EXACT [] synonym: "nucleoside monophosphate formation" EXACT [] synonym: "nucleoside monophosphate synthesis" EXACT [] is_a: GO:0009123 ! nucleoside monophosphate metabolic process is_a: GO:1901293 ! nucleoside phosphate biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009126 name: purine nucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "purine nucleoside monophosphate metabolism" EXACT [] is_a: GO:0009123 ! nucleoside monophosphate metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009127 name: purine nucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "purine nucleoside monophosphate anabolism" EXACT [] synonym: "purine nucleoside monophosphate biosynthesis" EXACT [] synonym: "purine nucleoside monophosphate formation" EXACT [] synonym: "purine nucleoside monophosphate synthesis" EXACT [] is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009132 name: nucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "nucleoside diphosphate metabolism" EXACT [] is_a: GO:0006753 ! nucleoside phosphate metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009141 name: nucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "nucleoside triphosphate metabolism" EXACT [] is_a: GO:0006753 ! nucleoside phosphate metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009142 name: nucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "nucleoside triphosphate anabolism" EXACT [] synonym: "nucleoside triphosphate biosynthesis" EXACT [] synonym: "nucleoside triphosphate formation" EXACT [] synonym: "nucleoside triphosphate synthesis" EXACT [] is_a: GO:0009141 ! nucleoside triphosphate metabolic process is_a: GO:1901293 ! nucleoside phosphate biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009144 name: purine nucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "purine nucleoside triphosphate metabolism" EXACT [] is_a: GO:0009141 ! nucleoside triphosphate metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009145 name: purine nucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "purine nucleoside triphosphate anabolism" EXACT [] synonym: "purine nucleoside triphosphate biosynthesis" EXACT [] synonym: "purine nucleoside triphosphate formation" EXACT [] synonym: "purine nucleoside triphosphate synthesis" EXACT [] is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009147 name: pyrimidine nucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "pyrimidine nucleoside triphosphate metabolism" EXACT [] is_a: GO:0009141 ! nucleoside triphosphate metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009148 name: pyrimidine nucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "pyrimidine nucleoside triphosphate anabolism" EXACT [] synonym: "pyrimidine nucleoside triphosphate biosynthesis" EXACT [] synonym: "pyrimidine nucleoside triphosphate formation" EXACT [] synonym: "pyrimidine nucleoside triphosphate synthesis" EXACT [] is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009150 name: purine ribonucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "purine ribonucleotide metabolism" EXACT [] is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009259 ! ribonucleotide metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009152 name: purine ribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "purine ribonucleotide anabolism" EXACT [] synonym: "purine ribonucleotide biosynthesis" EXACT [] synonym: "purine ribonucleotide formation" EXACT [] synonym: "purine ribonucleotide synthesis" EXACT [] is_a: GO:0006164 ! purine nucleotide biosynthetic process is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009260 ! ribonucleotide biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009156 name: ribonucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "ribonucleoside monophosphate anabolism" EXACT [] synonym: "ribonucleoside monophosphate biosynthesis" EXACT [] synonym: "ribonucleoside monophosphate formation" EXACT [] synonym: "ribonucleoside monophosphate synthesis" EXACT [] is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009161 name: ribonucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "ribonucleoside monophosphate metabolism" EXACT [] is_a: GO:0009123 ! nucleoside monophosphate metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009163 name: nucleoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713] subset: gosubset_prok synonym: "nucleoside anabolism" EXACT [] synonym: "nucleoside biosynthesis" EXACT [] synonym: "nucleoside formation" EXACT [] synonym: "nucleoside synthesis" EXACT [] is_a: GO:0009116 ! nucleoside metabolic process is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process is_a: GO:1901659 ! glycosyl compound biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009165 name: nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] subset: gosubset_prok synonym: "nucleotide anabolism" EXACT [] synonym: "nucleotide biosynthesis" EXACT [] synonym: "nucleotide formation" EXACT [] synonym: "nucleotide synthesis" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:1901293 ! nucleoside phosphate biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009167 name: purine ribonucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "purine ribonucleoside monophosphate metabolism" EXACT [] is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009168 name: purine ribonucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "purine ribonucleoside monophosphate anabolism" EXACT [] synonym: "purine ribonucleoside monophosphate biosynthesis" EXACT [] synonym: "purine ribonucleoside monophosphate formation" EXACT [] synonym: "purine ribonucleoside monophosphate synthesis" EXACT [] xref: Reactome:REACT_103616 "Purine ribonucleoside monophosphate biosynthesis, Danio rerio" xref: Reactome:REACT_105374 "Purine ribonucleoside monophosphate biosynthesis, Saccharomyces cerevisiae" xref: Reactome:REACT_106062 "Purine ribonucleoside monophosphate biosynthesis, Taeniopygia guttata" xref: Reactome:REACT_106423 "Purine ribonucleoside monophosphate biosynthesis, Gallus gallus" xref: Reactome:REACT_107566 "Purine ribonucleoside monophosphate biosynthesis, Dictyostelium discoideum" xref: Reactome:REACT_108408 "Purine ribonucleoside monophosphate biosynthesis, Mus musculus" xref: Reactome:REACT_1776 "Purine ribonucleoside monophosphate biosynthesis, Homo sapiens" xref: Reactome:REACT_28359 "Purine ribonucleoside monophosphate biosynthesis, Canis familiaris" xref: Reactome:REACT_30059 "Purine ribonucleoside monophosphate biosynthesis, Rattus norvegicus" xref: Reactome:REACT_30811 "Purine ribonucleoside monophosphate biosynthesis, Xenopus tropicalis" xref: Reactome:REACT_32997 "Purine ribonucleoside monophosphate biosynthesis, Escherichia coli" xref: Reactome:REACT_33659 "Purine ribonucleoside monophosphate biosynthesis, Sus scrofa" xref: Reactome:REACT_79911 "Purine ribonucleoside monophosphate biosynthesis, Arabidopsis thaliana" xref: Reactome:REACT_80409 "Purine ribonucleoside monophosphate biosynthesis, Caenorhabditis elegans" xref: Reactome:REACT_83164 "Purine ribonucleoside monophosphate biosynthesis, Plasmodium falciparum" xref: Reactome:REACT_84816 "Purine ribonucleoside monophosphate biosynthesis, Mycobacterium tuberculosis" xref: Reactome:REACT_87285 "Purine ribonucleoside monophosphate biosynthesis, Staphylococcus aureus N315" xref: Reactome:REACT_92581 "Purine ribonucleoside monophosphate biosynthesis, Bos taurus" xref: Reactome:REACT_92811 "Purine ribonucleoside monophosphate biosynthesis, Schizosaccharomyces pombe" xref: Reactome:REACT_93080 "Purine ribonucleoside monophosphate biosynthesis, Oryza sativa" xref: Reactome:REACT_96162 "Purine ribonucleoside monophosphate biosynthesis, Drosophila melanogaster" is_a: GO:0009127 ! purine nucleoside monophosphate biosynthetic process is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009187 name: cyclic nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "cyclic nucleotide metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009190 name: cyclic nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "cyclic nucleotide anabolism" EXACT [] synonym: "cyclic nucleotide biosynthesis" EXACT [] synonym: "cyclic nucleotide formation" EXACT [] synonym: "cyclic nucleotide synthesis" EXACT [] is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0009187 ! cyclic nucleotide metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009199 name: ribonucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "ribonucleoside triphosphate metabolism" EXACT [] is_a: GO:0009141 ! nucleoside triphosphate metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009200 name: deoxyribonucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "deoxyribonucleoside triphosphate metabolism" EXACT [] is_a: GO:0009141 ! nucleoside triphosphate metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009201 name: ribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "ribonucleoside triphosphate anabolism" EXACT [] synonym: "ribonucleoside triphosphate biosynthesis" EXACT [] synonym: "ribonucleoside triphosphate formation" EXACT [] synonym: "ribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009202 name: deoxyribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "deoxyribonucleoside triphosphate anabolism" EXACT [] synonym: "deoxyribonucleoside triphosphate biosynthesis" EXACT [] synonym: "deoxyribonucleoside triphosphate formation" EXACT [] synonym: "deoxyribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009205 name: purine ribonucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "purine ribonucleoside triphosphate metabolism" EXACT [] is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009206 name: purine ribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "purine ribonucleoside triphosphate anabolism" EXACT [] synonym: "purine ribonucleoside triphosphate biosynthesis" EXACT [] synonym: "purine ribonucleoside triphosphate formation" EXACT [] synonym: "purine ribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009145 ! purine nucleoside triphosphate biosynthetic process is_a: GO:0009201 ! ribonucleoside triphosphate biosynthetic process is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009211 name: pyrimidine deoxyribonucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "pyrimidine deoxyribonucleoside triphosphate metabolism" EXACT [] is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009212 name: pyrimidine deoxyribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "pyrimidine deoxyribonucleoside triphosphate anabolism" EXACT [] synonym: "pyrimidine deoxyribonucleoside triphosphate biosynthesis" EXACT [] synonym: "pyrimidine deoxyribonucleoside triphosphate formation" EXACT [] synonym: "pyrimidine deoxyribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009148 ! pyrimidine nucleoside triphosphate biosynthetic process is_a: GO:0009202 ! deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009219 name: pyrimidine deoxyribonucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a pyrimidine deoxynucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "pyrimidine deoxyribonucleotide metabolism" EXACT [] is_a: GO:0006220 ! pyrimidine nucleotide metabolic process is_a: GO:0009394 ! 2'-deoxyribonucleotide metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009221 name: pyrimidine deoxyribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "pyrimidine deoxyribonucleotide anabolism" EXACT [] synonym: "pyrimidine deoxyribonucleotide biosynthesis" EXACT [] synonym: "pyrimidine deoxyribonucleotide formation" EXACT [] synonym: "pyrimidine deoxyribonucleotide synthesis" EXACT [] xref: MetaCyc:PWY0-166 is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process is_a: GO:0009265 ! 2'-deoxyribonucleotide biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009250 name: glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." [GOC:go_curators] subset: gosubset_prok synonym: "glucan anabolism" EXACT [] synonym: "glucan biosynthesis" EXACT [] synonym: "glucan formation" EXACT [] synonym: "glucan synthesis" EXACT [] is_a: GO:0006073 ! cellular glucan metabolic process is_a: GO:0033692 ! cellular polysaccharide biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009259 name: ribonucleotide metabolic process namespace: biological_process alt_id: GO:0009121 def: "The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "ribonucleotide metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0019693 ! ribose phosphate metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009260 name: ribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "ribonucleotide anabolism" EXACT [] synonym: "ribonucleotide biosynthesis" EXACT [] synonym: "ribonucleotide formation" EXACT [] synonym: "ribonucleotide synthesis" EXACT [] is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0009259 ! ribonucleotide metabolic process is_a: GO:0046390 ! ribose phosphate biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009262 name: deoxyribonucleotide metabolic process namespace: biological_process alt_id: GO:0009122 alt_id: GO:0009393 def: "The chemical reactions and pathways involving a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "deoxyribonucleotide metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009263 name: deoxyribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "deoxyribonucleotide anabolism" EXACT [] synonym: "deoxyribonucleotide biosynthesis" EXACT [] synonym: "deoxyribonucleotide formation" EXACT [] synonym: "deoxyribonucleotide synthesis" EXACT [] is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0009262 ! deoxyribonucleotide metabolic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009265 name: 2'-deoxyribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:mah] subset: gosubset_prok synonym: "2'-deoxyribonucleotide anabolism" EXACT [] synonym: "2'-deoxyribonucleotide biosynthesis" EXACT [] synonym: "2'-deoxyribonucleotide formation" EXACT [] synonym: "2'-deoxyribonucleotide synthesis" EXACT [] is_a: GO:0009263 ! deoxyribonucleotide biosynthetic process is_a: GO:0009394 ! 2'-deoxyribonucleotide metabolic process is_a: GO:0046385 ! deoxyribose phosphate biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009266 name: response to temperature stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus." [GOC:hb] subset: gosubset_prok synonym: "response to thermal stimulus" EXACT [] is_a: GO:0009628 ! response to abiotic stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009267 name: cellular response to starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl] subset: gosubset_prok is_a: GO:0031669 ! cellular response to nutrient levels is_a: GO:0033554 ! cellular response to stress is_a: GO:0042594 ! response to starvation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009268 name: response to pH namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:jl, http://en.wikipedia.org/wiki/PH] subset: gosubset_prok is_a: GO:0009628 ! response to abiotic stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009272 name: fungal-type cell wall biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a fungal-type cell wall. The fungal-type cell wall contains beta-glucan and may contain chitin." [GOC:go_curators, GOC:mtg_sensu] synonym: "chitin- and beta-glucan-containing cell wall biogenesis" NARROW [GOC:mah] synonym: "fungal-type cell wall anabolism" RELATED [GOC:mah] synonym: "fungal-type cell wall biosynthetic process" RELATED [GOC:mah] synonym: "fungal-type cell wall formation" RELATED [GOC:mah] synonym: "fungal-type cell wall synthesis" RELATED [GOC:mah] is_a: GO:0042546 ! cell wall biogenesis is_a: GO:0071852 ! fungal-type cell wall organization or biogenesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009277 name: fungal-type cell wall namespace: cellular_component def: "A rigid yet dynamic structure surrounding the plasma membrane that affords protection from stresses and contributes to cell morphogenesis, consisting of extensively cross-linked glycoproteins and carbohydrates. The glycoproteins may be modified with N- or O-linked carbohydrates, or glycosylphosphatidylinositol (GPI) anchors; the polysaccharides are primarily branched glucans, including beta-linked and alpha-linked glucans, and may also include chitin and other carbohydrate polymers, but not cellulose or pectin. Enzymes involved in cell wall biosynthesis are also found in the cell wall. Note that some forms of fungi develop a capsule outside of the cell wall under certain circumstances; this is considered a separate structure." [GOC:mcc, GOC:mtg_sensu, ISBN:3540601864, PMID:11283274, PMID:16927300, PMID:3319422] synonym: "beta-glucan-containing cell wall" RELATED [] synonym: "chitin- and beta-glucan-containing cell wall" NARROW [] synonym: "chitin-containing cell wall" RELATED [] is_a: GO:0005618 ! cell wall property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009295 name: nucleoid namespace: cellular_component def: "The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined." [GOC:bm, GOC:ma, ISBN:3540076689] subset: goslim_metagenomics subset: gosubset_prok xref: Wikipedia:Nucleoid is_a: GO:0005575 ! cellular_component property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009300 name: antisense RNA transcription namespace: biological_process def: "The synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA." [GOC:jl] subset: gosubset_prok is_a: GO:0006351 ! transcription, DNA-templated is_a: GO:0042868 ! antisense RNA metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009303 name: rRNA transcription namespace: biological_process def: "The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template." [GOC:jl, ISBN:0198506732] subset: gosubset_prok synonym: "rRNA biosynthesis" BROAD [] synonym: "rRNA biosynthetic process" BROAD [] synonym: "rRNA synthesis" BROAD [] is_a: GO:0098781 ! ncRNA transcription property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009306 name: protein secretion namespace: biological_process alt_id: GO:0045166 alt_id: GO:0045731 def: "The controlled release of proteins from a cell." [GOC:ai] subset: goslim_metagenomics subset: gosubset_prok synonym: "glycoprotein secretion" NARROW [] synonym: "protein secretion during cell fate commitment" NARROW [] synonym: "protein secretion resulting in cell fate commitment" NARROW [] is_a: GO:0015031 ! protein transport is_a: GO:0032940 ! secretion by cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009311 name: oligosaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732] subset: goslim_yeast subset: gosubset_prok synonym: "oligosaccharide metabolism" EXACT [] is_a: GO:0044723 ! single-organism carbohydrate metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009314 name: response to radiation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation] comment: Note that 'radiation' refers to electromagnetic radiation of any wavelength. subset: gosubset_prok synonym: "response to electromagnetic radiation stimulus" EXACT [] synonym: "response to radiation stimulus" EXACT [] is_a: GO:0009628 ! response to abiotic stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009371 name: positive regulation of transcription by pheromones namespace: biological_process def: "Any process involving pheromones that activates or increases the rate of transcription." [GOC:go_curators] subset: gosubset_prok synonym: "activation of transcription by pheromones" NARROW [] synonym: "stimulation of transcription by pheromones" NARROW [] synonym: "up regulation of transcription by pheromones" EXACT [] synonym: "up-regulation of transcription by pheromones" EXACT [] synonym: "upregulation of transcription by pheromones" EXACT [] is_a: GO:0009373 ! regulation of transcription by pheromones is_a: GO:0045893 ! positive regulation of transcription, DNA-templated property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009373 name: regulation of transcription by pheromones namespace: biological_process def: "Any process involving pheromones that modulates the frequency, rate or extent of transcription." [GOC:go_curators] subset: gosubset_prok is_a: GO:0006355 ! regulation of transcription, DNA-templated relationship: part_of GO:0071444 ! cellular response to pheromone property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009394 name: 2'-deoxyribonucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:mah] subset: gosubset_prok synonym: "2'-deoxyribonucleotide metabolism" EXACT [] is_a: GO:0009262 ! deoxyribonucleotide metabolic process is_a: GO:0019692 ! deoxyribose phosphate metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009408 name: response to heat namespace: biological_process alt_id: GO:0006951 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] subset: goslim_yeast subset: gosubset_prok synonym: "response to heat shock" NARROW [] is_a: GO:0006950 ! response to stress is_a: GO:0009266 ! response to temperature stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009409 name: response to cold namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:lr] subset: gosubset_prok synonym: "freezing tolerance" RELATED [] is_a: GO:0006950 ! response to stress is_a: GO:0009266 ! response to temperature stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009411 name: response to UV namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb] subset: gosubset_prok synonym: "response to ultraviolet light stimulus" EXACT [] synonym: "response to ultraviolet radiation stimulus" EXACT [] synonym: "response to UV light stimulus" EXACT [] synonym: "response to UV radiation stimulus" EXACT [] is_a: GO:0009416 ! response to light stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009414 name: response to water deprivation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water." [GOC:lr] subset: gosubset_prok synonym: "drought tolerance" RELATED [] synonym: "response to dehydration" EXACT [] synonym: "response to drought" EXACT [] synonym: "response to thirst" EXACT [] is_a: GO:0006950 ! response to stress is_a: GO:0009415 ! response to water property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009415 name: response to water namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water." [GOC:jl] subset: gosubset_prok synonym: "response to water stimulus" EXACT [GOC:dos] is_a: GO:0001101 ! response to acid chemical is_a: GO:0009628 ! response to abiotic stimulus is_a: GO:0010035 ! response to inorganic substance is_a: GO:1901700 ! response to oxygen-containing compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009416 name: response to light stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089] subset: gosubset_prok is_a: GO:0009314 ! response to radiation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009438 name: methylglyoxal metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid." [CHEBI:17158, GOC:ai] subset: gosubset_prok synonym: "methylglyoxal bypass" NARROW [] synonym: "methylglyoxal metabolism" EXACT [] synonym: "methylglyoxal pathway" NARROW [] xref: MetaCyc:METHGLYUT-PWY is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0042180 ! cellular ketone metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009451 name: RNA modification namespace: biological_process alt_id: GO:0016547 def: "The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically." [GOC:go_curators, ISBN:1555811337] comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. subset: goslim_yeast subset: gosubset_prok synonym: "RNA editing" NARROW [GOC:hjd] xref: Wikipedia:RNA_editing is_a: GO:0016070 ! RNA metabolic process is_a: GO:0043412 ! macromolecule modification property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009593 name: detection of chemical stimulus namespace: biological_process def: "The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." [GOC:jl] synonym: "chemoperception" EXACT [] synonym: "detection of chemical substance" EXACT [] synonym: "perception of chemical stimulus" RELATED [] synonym: "perception of chemical substance" RELATED [] is_a: GO:0051606 ! detection of stimulus relationship: part_of GO:0042221 ! response to chemical property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009605 name: response to external stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_plant subset: gosubset_prok synonym: "response to environmental stimulus" EXACT [] is_a: GO:0050896 ! response to stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009607 name: response to biotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_plant subset: gosubset_prok synonym: "response to biotic stress" NARROW [] is_a: GO:0050896 ! response to stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009628 name: response to abiotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus." [GOC:hb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_plant subset: gosubset_prok synonym: "response to abiotic stress" NARROW [] is_a: GO:0050896 ! response to stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009651 name: response to salt stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl] subset: gosubset_prok synonym: "response to ionic osmotic stress" EXACT [] synonym: "salinity response" EXACT [] is_a: GO:0006970 ! response to osmotic stress property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009653 name: anatomical structure morphogenesis namespace: biological_process def: "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125] subset: goslim_plant subset: gosubset_prok synonym: "anatomical structure organization" EXACT [] synonym: "embryogenesis and morphogenesis" BROAD [] synonym: "morphogenesis" EXACT [] xref: Wikipedia:Morphogenesis is_a: GO:0032502 ! developmental process relationship: part_of GO:0048856 ! anatomical structure development property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009719 name: response to endogenous stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_plant subset: gosubset_prok is_a: GO:0050896 ! response to stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009743 name: response to carbohydrate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus." [GOC:jl] synonym: "response to carbohydrate stimulus" EXACT [GOC:dos] is_a: GO:0010033 ! response to organic substance is_a: GO:1901700 ! response to oxygen-containing compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009746 name: response to hexose namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus." [GOC:jl] synonym: "response to hexose stimulus" EXACT [GOC:dos] is_a: GO:0034284 ! response to monosaccharide property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009749 name: response to glucose namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:jl] synonym: "response to glucose stimulus" EXACT [GOC:dos] is_a: GO:0009746 ! response to hexose property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009826 name: unidimensional cell growth namespace: biological_process def: "The process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis, resulting in the morphogenesis of the cell." [ISBN:0943088399] comment: Unidimensional cell growth refers to a change in both cell size and cell shape. For cell shape changes where cell size is not affected, consider instead the term 'regulation of cell shape ; GO:0008360' and its children. subset: gosubset_prok synonym: "cell elongation" NARROW [] synonym: "cell growth along one axis" EXACT [] synonym: "cell growth in one dimension" EXACT [] synonym: "cell morphogenesis by unidimensional growth" EXACT [GOC:dph, GOC:tb] synonym: "polar cell growth" EXACT [] synonym: "polarized cell growth" EXACT [] is_a: GO:0000902 ! cell morphogenesis is_a: GO:0016049 ! cell growth is_a: GO:0060560 ! developmental growth involved in morphogenesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009847 name: spore germination namespace: biological_process def: "The physiological and developmental changes that occur in a spore following release from dormancy up to the earliest signs of growth (e.g. emergence from a spore wall)." [GOC:lr] subset: gosubset_prok is_a: GO:0032502 ! developmental process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009889 name: regulation of biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of anabolism" EXACT [] synonym: "regulation of biosynthesis" EXACT [] synonym: "regulation of formation" EXACT [] synonym: "regulation of synthesis" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009058 ! biosynthetic process relationship: regulates GO:0009058 ! biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009890 name: negative regulation of biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of biosynthetic process" EXACT [] synonym: "down-regulation of biosynthetic process" EXACT [] synonym: "downregulation of biosynthetic process" EXACT [] synonym: "inhibition of biosynthetic process" NARROW [] synonym: "negative regulation of anabolism" EXACT [] synonym: "negative regulation of biosynthesis" EXACT [] synonym: "negative regulation of formation" EXACT [] synonym: "negative regulation of synthesis" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0009892 ! negative regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009058 ! biosynthetic process relationship: negatively_regulates GO:0009058 ! biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009891 name: positive regulation of biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] subset: gosubset_prok synonym: "activation of biosynthetic process" NARROW [] synonym: "positive regulation of anabolism" EXACT [] synonym: "positive regulation of biosynthesis" EXACT [] synonym: "positive regulation of formation" EXACT [] synonym: "positive regulation of synthesis" EXACT [] synonym: "stimulation of biosynthetic process" NARROW [] synonym: "up regulation of biosynthetic process" EXACT [] synonym: "up-regulation of biosynthetic process" EXACT [] synonym: "upregulation of biosynthetic process" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0009893 ! positive regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009058 ! biosynthetic process relationship: positively_regulates GO:0009058 ! biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009892 name: negative regulation of metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of metabolic process" EXACT [] synonym: "down-regulation of metabolic process" EXACT [] synonym: "downregulation of metabolic process" EXACT [] synonym: "inhibition of metabolic process" NARROW [] synonym: "negative regulation of metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0008152 ! metabolic process relationship: negatively_regulates GO:0008152 ! metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009893 name: positive regulation of metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] subset: gosubset_prok synonym: "activation of metabolic process" NARROW [] synonym: "positive regulation of metabolism" EXACT [] synonym: "stimulation of metabolic process" NARROW [] synonym: "up regulation of metabolic process" EXACT [] synonym: "up-regulation of metabolic process" EXACT [] synonym: "upregulation of metabolic process" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0008152 ! metabolic process relationship: positively_regulates GO:0008152 ! metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009894 name: regulation of catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of breakdown" EXACT [] synonym: "regulation of catabolism" EXACT [] synonym: "regulation of degradation" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009056 ! catabolic process relationship: regulates GO:0009056 ! catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009895 name: negative regulation of catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of catabolic process" EXACT [] synonym: "down-regulation of catabolic process" EXACT [] synonym: "downregulation of catabolic process" EXACT [] synonym: "inhibition of catabolic process" NARROW [] synonym: "negative regulation of breakdown" EXACT [] synonym: "negative regulation of catabolism" EXACT [] synonym: "negative regulation of degradation" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0009894 ! regulation of catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009056 ! catabolic process relationship: negatively_regulates GO:0009056 ! catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009896 name: positive regulation of catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] subset: gosubset_prok synonym: "activation of catabolic process" NARROW [] synonym: "positive regulation of breakdown" EXACT [] synonym: "positive regulation of catabolism" EXACT [] synonym: "positive regulation of degradation" EXACT [] synonym: "stimulation of catabolic process" NARROW [] synonym: "up regulation of catabolic process" EXACT [] synonym: "up-regulation of catabolic process" EXACT [] synonym: "upregulation of catabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0009894 ! regulation of catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009056 ! catabolic process relationship: positively_regulates GO:0009056 ! catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009966 name: regulation of signal transduction namespace: biological_process alt_id: GO:0035466 def: "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm] subset: gosubset_prok synonym: "regulation of signaling pathway" RELATED [] synonym: "regulation of signalling pathway" RELATED [GOC:mah] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0023051 ! regulation of signaling is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007165 ! signal transduction relationship: regulates GO:0007165 ! signal transduction property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009975 name: cyclase activity namespace: molecular_function def: "Catalysis of a ring closure reaction." [ISBN:0198547684] subset: goslim_pir subset: gosubset_prok is_a: GO:0003824 ! catalytic activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009986 name: cell surface namespace: cellular_component alt_id: GO:0009928 alt_id: GO:0009929 def: "The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm] comment: Note that this term is intended to annotate gene products that are attached (integrated or loosely bound) to the plasma membrane or cell wall. subset: goslim_pir subset: gosubset_prok synonym: "cell associated" EXACT [] synonym: "cell bound" EXACT [] is_a: GO:0044464 ! cell part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009987 name: cellular process namespace: biological_process alt_id: GO:0008151 alt_id: GO:0050875 def: "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "cell growth and/or maintenance" NARROW [] synonym: "cell physiology" EXACT [] synonym: "cellular physiological process" EXACT [] is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0009991 name: response to extracellular stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus." [GOC:go_curators] subset: goslim_plant subset: gosubset_prok is_a: GO:0009605 ! response to external stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010032 name: meiotic chromosome condensation namespace: biological_process def: "Compaction of chromatin structure prior to meiosis in eukaryotic cells." [PMID:10072401] synonym: "chromosome condensation involved in meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0030261 ! chromosome condensation is_a: GO:0070192 ! chromosome organization involved in meiosis intersection_of: GO:0030261 ! chromosome condensation intersection_of: part_of GO:0051321 ! meiotic cell cycle relationship: part_of GO:0051321 ! meiotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010033 name: response to organic substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm] subset: gosubset_prok is_a: GO:0042221 ! response to chemical property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010035 name: response to inorganic substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus." [GOC:sm] subset: gosubset_prok is_a: GO:0042221 ! response to chemical property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010038 name: response to metal ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm] subset: gosubset_prok synonym: "heavy metal sensitivity/resistance" RELATED [] synonym: "response to heavy metal" NARROW [] synonym: "response to metal" EXACT [] is_a: GO:0010035 ! response to inorganic substance property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010039 name: response to iron ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus." [GOC:sm] synonym: "response to iron" EXACT [] is_a: GO:0010038 ! response to metal ion is_a: GO:1990267 ! response to transition metal nanoparticle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010043 name: response to zinc ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus." [GOC:sm] synonym: "response to zinc" EXACT [] is_a: GO:0010038 ! response to metal ion is_a: GO:1990267 ! response to transition metal nanoparticle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010106 name: cellular response to iron ion starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of iron ions." [GOC:mg] is_a: GO:0009267 ! cellular response to starvation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010212 name: response to ionizing radiation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [PMID:12509526] synonym: "response to ionising radiation" EXACT [] synonym: "response to ionizing radiation stimulus" EXACT [] is_a: GO:0009314 ! response to radiation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010243 name: response to organonitrogen compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond." [CHEBI:35352, PMID:9869419] synonym: "response to organic nitrogen" EXACT [] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0010033 ! response to organic substance is_a: GO:1901698 ! response to nitrogen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010256 name: endomembrane system organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system." [GOC:mah, GOC:sm] synonym: "endomembrane organization" EXACT [GOC:curators] synonym: "endomembrane system organisation" EXACT [GOC:mah] is_a: GO:0016043 ! cellular component organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010266 name: response to vitamin B1 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B1 stimulus." [GOC:pz] synonym: "response to thiamin" EXACT [] synonym: "response to thiamine" EXACT [] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033273 ! response to vitamin property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010272 name: response to silver ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silver ion stimulus." [PMID:16367966] is_a: GO:0010038 ! response to metal ion is_a: GO:1990267 ! response to transition metal nanoparticle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010324 name: membrane invagination namespace: biological_process def: "The infolding of a membrane, resulting in formation of a vesicle." [GOC:tb] subset: goslim_yeast is_a: GO:0061024 ! membrane organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010332 name: response to gamma radiation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:tair_curators, Wikipedia:Gamma_ray] synonym: "response to gamma ray" RELATED [] synonym: "response to gamma-ray photon" RELATED [] is_a: GO:0010212 ! response to ionizing radiation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010335 name: response to non-ionic osmotic stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of non-ionic solutes (e.g. mannitol, sorbitol) in the environment." [GOC:tair_curators] is_a: GO:0006970 ! response to osmotic stress property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010389 name: regulation of G2/M transition of mitotic cell cycle namespace: biological_process def: "Any process that modulates the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle." [GOC:mtg_cell_cycle, PMID:17329565] synonym: "regulation of mitotic entry" EXACT [GOC:vw] is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition is_a: GO:1902749 ! regulation of cell cycle G2/M phase transition intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0000086 ! G2/M transition of mitotic cell cycle relationship: regulates GO:0000086 ! G2/M transition of mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010452 name: histone H3-K36 methylation namespace: biological_process def: "The modification of histone H3 by addition of a methyl group to lysine at position 36 of the histone." [GOC:tb] synonym: "histone H3 K36 methylation" EXACT [GOC:tb] synonym: "histone H3K36me" EXACT [GOC:tb] synonym: "histone lysine H3 K36 methylation" EXACT [GOC:tb] is_a: GO:0034968 ! histone lysine methylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010453 name: regulation of cell fate commitment namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0045165 ! cell fate commitment relationship: regulates GO:0045165 ! cell fate commitment property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010458 name: exit from mitosis namespace: biological_process def: "The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb] synonym: "mitotic exit" EXACT [] is_a: GO:0044772 ! mitotic cell cycle phase transition relationship: part_of GO:0007067 ! mitotic nuclear division property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010467 name: gene expression namespace: biological_process def: "The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] subset: gosubset_prok xref: Reactome:REACT_100537 "Gene Expression, Xenopus tropicalis" xref: Reactome:REACT_101147 "Gene Expression, Danio rerio" xref: Reactome:REACT_101952 "Gene Expression, Sus scrofa" xref: Reactome:REACT_105649 "Gene Expression, Drosophila melanogaster" xref: Reactome:REACT_108313 "Gene Expression, Caenorhabditis elegans" xref: Reactome:REACT_29068 "Gene Expression, Escherichia coli" xref: Reactome:REACT_34240 "Gene Expression, Staphylococcus aureus N315" xref: Reactome:REACT_71 "Gene Expression, Homo sapiens" xref: Reactome:REACT_78136 "Gene Expression, Mus musculus" xref: Reactome:REACT_78959 "Gene Expression, Taeniopygia guttata" xref: Reactome:REACT_79662 "Gene Expression, Plasmodium falciparum" xref: Reactome:REACT_85241 "Gene Expression, Oryza sativa" xref: Reactome:REACT_85359 "Gene Expression, Gallus gallus" xref: Reactome:REACT_86357 "Gene Expression, Canis familiaris" xref: Reactome:REACT_89816 "Gene Expression, Mycobacterium tuberculosis" xref: Reactome:REACT_91657 "Gene Expression, Arabidopsis thaliana" xref: Reactome:REACT_91965 "Gene Expression, Rattus norvegicus" xref: Reactome:REACT_93586 "Gene Expression, Dictyostelium discoideum" xref: Reactome:REACT_93968 "Gene Expression, Bos taurus" xref: Reactome:REACT_94814 "Gene Expression, Schizosaccharomyces pombe" xref: Reactome:REACT_98256 "Gene Expression, Saccharomyces cerevisiae" xref: Wikipedia:Gene_expression is_a: GO:0043170 ! macromolecule metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010468 name: regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] comment: This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availabiliy of mRNA for translation and thereby regulates the rate of production of the encoded protein via translation. subset: gosubset_prok synonym: "regulation of gene product expression" RELATED [GOC:curators] synonym: "regulation of protein expression" NARROW [GOC:curators] xref: Wikipedia:Regulation_of_gene_expression is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0010467 ! gene expression relationship: regulates GO:0010467 ! gene expression property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010498 name: proteasomal protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb] synonym: "proteasome-mediated protein catabolic process" EXACT [] synonym: "proteasome-mediated protein catabolism" EXACT [] is_a: GO:0030163 ! protein catabolic process is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010556 name: regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] subset: gosubset_prok is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009059 ! macromolecule biosynthetic process relationship: regulates GO:0009059 ! macromolecule biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010557 name: positive regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0010604 ! positive regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009059 ! macromolecule biosynthetic process relationship: positively_regulates GO:0009059 ! macromolecule biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010558 name: negative regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0010605 ! negative regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009059 ! macromolecule biosynthetic process relationship: negatively_regulates GO:0009059 ! macromolecule biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010564 name: regulation of cell cycle process namespace: biological_process def: "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0022402 ! cell cycle process relationship: regulates GO:0022402 ! cell cycle process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010570 name: regulation of filamentous growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process in which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:dph, GOC:jp, GOC:tb] is_a: GO:0040008 ! regulation of growth intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0030447 ! filamentous growth relationship: regulates GO:0030447 ! filamentous growth property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010590 name: regulation of cell separation after cytokinesis namespace: biological_process alt_id: GO:1902467 alt_id: GO:2001041 def: "Any process that modulates the rate, frequency or extent of the process of physically separating progeny cells after cytokinesis; this may involve enzymatic digestion of septum or cell wall components." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:19959363, PMID:21246752, PMID:22786806] synonym: "regulation of cell separation following cytokinesis" RELATED [GOC:dph, GOC:tb] synonym: "regulation of mitotic cytokinetic cell separation" EXACT [] is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0000920 ! cell separation after cytokinesis relationship: regulates GO:0000920 ! cell separation after cytokinesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010604 name: positive regulation of macromolecule metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0043170 ! macromolecule metabolic process relationship: positively_regulates GO:0043170 ! macromolecule metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010605 name: negative regulation of macromolecule metabolic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0043170 ! macromolecule metabolic process relationship: negatively_regulates GO:0043170 ! macromolecule metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010608 name: posttranscriptional regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb] is_a: GO:0010468 ! regulation of gene expression property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010628 name: positive regulation of gene expression namespace: biological_process def: "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0010604 ! positive regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0010467 ! gene expression relationship: positively_regulates GO:0010467 ! gene expression property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010629 name: negative regulation of gene expression namespace: biological_process def: "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] comment: This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availabiliy of mRNA for translation and thereby reduces the rate of production of the encoded protein via translation. is_a: GO:0010468 ! regulation of gene expression is_a: GO:0010605 ! negative regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0010467 ! gene expression relationship: negatively_regulates GO:0010467 ! gene expression property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010638 name: positive regulation of organelle organization namespace: biological_process def: "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] synonym: "positive regulation of organelle organisation" EXACT [GOC:mah] synonym: "positive regulation of organelle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0051130 ! positive regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006996 ! organelle organization relationship: positively_regulates GO:0006996 ! organelle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010639 name: negative regulation of organelle organization namespace: biological_process def: "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] synonym: "negative regulation of organelle organisation" EXACT [GOC:mah] synonym: "negative regulation of organelle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0051129 ! negative regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006996 ! organelle organization relationship: negatively_regulates GO:0006996 ! organelle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010646 name: regulation of cell communication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007154 ! cell communication relationship: regulates GO:0007154 ! cell communication property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010927 name: cellular component assembly involved in morphogenesis namespace: biological_process def: "The cellular component assembly that is part of the initial shaping of the component during its developmental progression." [GOC:dph, GOC:tb] is_a: GO:0022607 ! cellular component assembly is_a: GO:0044763 ! single-organism cellular process is_a: GO:0044767 ! single-organism developmental process is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis intersection_of: GO:0022607 ! cellular component assembly intersection_of: part_of GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0032989 ! cellular component morphogenesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010938 name: cytoplasmic microtubule depolymerization namespace: biological_process def: "The removal of tubulin heterodimers from one or both ends of a cytoplasmic microtubule." [GOC:dph, GOC:tb] is_a: GO:0007019 ! microtubule depolymerization is_a: GO:0031122 ! cytoplasmic microtubule organization intersection_of: GO:0007019 ! microtubule depolymerization intersection_of: occurs_in GO:0005737 ! cytoplasm relationship: occurs_in GO:0005737 ! cytoplasm property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0010948 name: negative regulation of cell cycle process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0045786 ! negative regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0022402 ! cell cycle process relationship: negatively_regulates GO:0022402 ! cell cycle process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2009-04-27T09:53:22Z [Term] id: GO:0010965 name: regulation of mitotic sister chromatid separation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic sister chromatid separation. Mitotic sister chromatid separation is the process in which sister chromatids are physically detached from each other during mitosis." [GOC:dph, GOC:tb] is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0051306 ! mitotic sister chromatid separation relationship: regulates GO:0051306 ! mitotic sister chromatid separation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2009-05-20T11:39:07Z [Term] id: GO:0010970 name: microtubule-based transport namespace: biological_process def: "Microtubule-based movement that results in the net, directed movement of organelles or other particles from one location in the cell to another." [GOC:dph, GOC:mah, GOC:tb] is_a: GO:0007018 ! microtubule-based movement is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2009-05-27T10:56:08Z [Term] id: GO:0010972 name: negative regulation of G2/M transition of mitotic cell cycle namespace: biological_process def: "Any cell cycle regulatory process that decreases the rate or extent of progression of a cell from G2 to M phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] synonym: "negative regulation of mitotic entry" EXACT [GOC:vw] is_a: GO:0010389 ! regulation of G2/M transition of mitotic cell cycle is_a: GO:1901991 ! negative regulation of mitotic cell cycle phase transition is_a: GO:1902750 ! negative regulation of cell cycle G2/M phase transition intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0000086 ! G2/M transition of mitotic cell cycle relationship: negatively_regulates GO:0000086 ! G2/M transition of mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2009-06-01T10:18:29Z [Term] id: GO:0010997 name: anaphase-promoting complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis." [GOC:BHF, GOC:dph, GOC:tb] synonym: "APC binding" EXACT [GOC:dph, GOC:tb] is_a: GO:0032403 ! protein complex binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2009-06-10T11:18:22Z [Term] id: GO:0011000 name: replication fork arrest at mating type locus namespace: biological_process def: "A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the mating type locus." [GOC:dph, GOC:tb] is_a: GO:0043111 ! replication fork arrest property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2009-06-24T12:02:48Z [Term] id: GO:0012501 name: programmed cell death namespace: biological_process alt_id: GO:0016244 def: "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] comment: Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children, which are descendants of GO:0034050 'host programmed cell death induced by symbiont'. synonym: "caspase-independent apoptosis" RELATED [] synonym: "caspase-independent cell death" NARROW [] synonym: "non-apoptotic programmed cell death" NARROW [] synonym: "nonapoptotic programmed cell death" NARROW [] synonym: "PCD" EXACT [] synonym: "regulated cell death" RELATED [] xref: Wikipedia:Programmed_cell_death is_a: GO:0008219 ! cell death property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0012505 name: endomembrane system namespace: cellular_component def: "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] subset: goslim_aspergillus subset: goslim_candida subset: goslim_yeast xref: Wikipedia:Endomembrane_system is_a: GO:0044464 ! cell part relationship: has_part GO:0005773 ! vacuole relationship: has_part GO:0005886 ! plasma membrane property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0014070 name: response to organic cyclic compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus." [CHEBI:33832, GOC:ef] synonym: "response to organic cyclic substance" EXACT [GOC:mah] is_a: GO:0010033 ! response to organic substance property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0014074 name: response to purine-containing compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus." [CHEBI:26401, GOC:ef] synonym: "response to purine" RELATED [GOC:curators] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015002 name: heme-copper terminal oxidase activity namespace: molecular_function def: "Catalysis of the four-electron reduction of dioxygen (O2) to water, coupled to generation of a proton electrochemical gradient across a membrane." [GOC:kd] subset: gosubset_prok synonym: "haem-copper terminal oxidase activity" EXACT [] is_a: GO:0016491 ! oxidoreductase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015031 name: protein transport namespace: biological_process alt_id: GO:0015831 def: "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "enzyme transport" NARROW [] is_a: GO:0008104 ! protein localization is_a: GO:0045184 ! establishment of protein localization is_a: GO:0071702 ! organic substance transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015035 name: protein disulfide oxidoreductase activity namespace: molecular_function alt_id: GO:0008895 def: "Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN] subset: gosubset_prok synonym: "haem lyase disulphide oxidoreductase activity" NARROW [] synonym: "heme lyase disulfide oxidoreductase activity" NARROW [] synonym: "protein disulphide oxidoreductase activity" EXACT [] synonym: "thioredoxin activity" NARROW [GOC:mah, GOC:vw] xref: MetaCyc:DISULFOXRED-RXN is_a: GO:0015036 ! disulfide oxidoreductase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015036 name: disulfide oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN] subset: gosubset_prok synonym: "disulphide oxidoreductase activity" EXACT [] xref: Reactome:REACT_103411 "Oxidation of Cysteine to Cystine in Proinsulin, Canis familiaris" xref: Reactome:REACT_106321 "Oxidation of Cysteine to Cystine in Proinsulin, Gallus gallus" xref: Reactome:REACT_107245 "Oxidation of Cysteine to Cystine in Proinsulin, Rattus norvegicus" xref: Reactome:REACT_107998 "Oxidation of Cysteine to Cystine in Proinsulin, Mus musculus" xref: Reactome:REACT_108531 "Oxidation of Cysteine to Cystine in Proinsulin, Danio rerio" xref: Reactome:REACT_15454 "Oxidation of Cysteine to Cystine in Proinsulin, Homo sapiens" xref: Reactome:REACT_77430 "Oxidation of Cysteine to Cystine in Proinsulin, Bos taurus" xref: Reactome:REACT_77708 "Oxidation of Cysteine to Cystine in Proinsulin, Xenopus tropicalis" xref: Reactome:REACT_96324 "Oxidation of Cysteine to Cystine in Proinsulin, Taeniopygia guttata" is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015037 name: peptide disulfide oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: a peptide with reduced sulfide groups = a peptide with oxidized disulfide bonds." [GOC:mah, MetaCyc:DISULFOXRED-RXN] subset: gosubset_prok synonym: "peptide disulphide oxidoreductase activity" EXACT [] is_a: GO:0015036 ! disulfide oxidoreductase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015038 name: glutathione disulfide oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor." [GOC:mah] subset: gosubset_prok synonym: "glutaredoxin" RELATED [] synonym: "glutathione disulphide oxidoreductase activity" EXACT [] xref: Reactome:REACT_104955 "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized), Mus musculus" xref: Reactome:REACT_108454 "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized), Xenopus tropicalis" xref: Reactome:REACT_112460 "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized), Arabidopsis thaliana" xref: Reactome:REACT_114108 "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized), Oryza sativa" xref: Reactome:REACT_114787 "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized), Plasmodium falciparum" xref: Reactome:REACT_1461 "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized), Homo sapiens" xref: Reactome:REACT_31672 "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized), Caenorhabditis elegans" xref: Reactome:REACT_32436 "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized), Danio rerio" xref: Reactome:REACT_34589 "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized), Canis familiaris" xref: Reactome:REACT_77557 "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized), Rattus norvegicus" xref: Reactome:REACT_84272 "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized), Gallus gallus" xref: Reactome:REACT_89388 "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized), Sus scrofa" xref: Reactome:REACT_94243 "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized), Bos taurus" is_a: GO:0015037 ! peptide disulfide oxidoreductase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015075 name: ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "ion transporter activity" EXACT [] is_a: GO:0022891 ! substrate-specific transmembrane transporter activity relationship: part_of GO:0034220 ! ion transmembrane transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015077 name: monovalent inorganic cation transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok is_a: GO:0022890 ! inorganic cation transmembrane transporter activity relationship: part_of GO:0015672 ! monovalent inorganic cation transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015078 name: hydrogen ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of hydrogen ions from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "proton transporter activity" EXACT [] xref: Reactome:REACT_100267 "Endosome acidification, Bos taurus" xref: Reactome:REACT_100622 "Endosome acidification, Plasmodium falciparum" xref: Reactome:REACT_103509 "Protons are translocated from the intermembrane space to the matrix, Taeniopygia guttata" xref: Reactome:REACT_103825 "Endosome acidification, Gallus gallus" xref: Reactome:REACT_107684 "Endosome acidification, Rattus norvegicus" xref: Reactome:REACT_107970 "Protons are translocated from the intermembrane space to the matrix, Bos taurus" xref: Reactome:REACT_108933 "Protons are translocated from the intermembrane space to the matrix, Oryza sativa" xref: Reactome:REACT_1985 "Enzyme-bound ATP is released, Homo sapiens" xref: Reactome:REACT_2002 "Endosome acidification, Homo sapiens" xref: Reactome:REACT_25268 "Acidification of Tf:TfR1 containing endosome, Homo sapiens" xref: Reactome:REACT_29417 "Enzyme-bound ATP is released, Bos taurus" xref: Reactome:REACT_29424 "Protons are translocated from the intermembrane space to the matrix, Gallus gallus" xref: Reactome:REACT_33554 "Endosome acidification, Schizosaccharomyces pombe" xref: Reactome:REACT_34522 "Endosome acidification, Sus scrofa" xref: Reactome:REACT_6312 "Protons are translocated from the intermembrane space to the matrix, Homo sapiens" xref: Reactome:REACT_77087 "Protons are translocated from the intermembrane space to the matrix, Sus scrofa" xref: Reactome:REACT_77222 "Enzyme-bound ATP is released, Canis familiaris" xref: Reactome:REACT_79096 "Endosome acidification, Dictyostelium discoideum" xref: Reactome:REACT_79130 "Enzyme-bound ATP is released, Mus musculus" xref: Reactome:REACT_81591 "Endosome acidification, Taeniopygia guttata" xref: Reactome:REACT_82120 "Enzyme-bound ATP is released, Gallus gallus" xref: Reactome:REACT_84002 "Endosome acidification, Mus musculus" xref: Reactome:REACT_86695 "Endosome acidification, Drosophila melanogaster" xref: Reactome:REACT_87088 "Endosome acidification, Xenopus tropicalis" xref: Reactome:REACT_88718 "Enzyme-bound ATP is released, Rattus norvegicus" xref: Reactome:REACT_88914 "Protons are translocated from the intermembrane space to the matrix, Canis familiaris" xref: Reactome:REACT_89361 "Protons are translocated from the intermembrane space to the matrix, Arabidopsis thaliana" xref: Reactome:REACT_90226 "Protons are translocated from the intermembrane space to the matrix, Xenopus tropicalis" xref: Reactome:REACT_91476 "Protons are translocated from the intermembrane space to the matrix, Mus musculus" xref: Reactome:REACT_93236 "Enzyme-bound ATP is released, Danio rerio" xref: Reactome:REACT_93447 "Protons are translocated from the intermembrane space to the matrix, Danio rerio" xref: Reactome:REACT_94558 "Endosome acidification, Danio rerio" xref: Reactome:REACT_95835 "Endosome acidification, Arabidopsis thaliana" xref: Reactome:REACT_96838 "Endosome acidification, Saccharomyces cerevisiae" xref: Reactome:REACT_97023 "Endosome acidification, Caenorhabditis elegans" xref: Reactome:REACT_97452 "Endosome acidification, Oryza sativa" xref: Reactome:REACT_97485 "Enzyme-bound ATP is released, Sus scrofa" xref: Reactome:REACT_98826 "Endosome acidification, Canis familiaris" xref: Reactome:REACT_99893 "Protons are translocated from the intermembrane space to the matrix, Rattus norvegicus" is_a: GO:0015077 ! monovalent inorganic cation transmembrane transporter activity relationship: part_of GO:1902600 ! hydrogen ion transmembrane transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015081 name: sodium ion transmembrane transporter activity namespace: molecular_function alt_id: GO:0022816 def: "Enables the transfer of sodium ions (Na+) from one side of a membrane to the other." [GOC:ai, GOC:BHF] subset: gosubset_prok synonym: "sodium transporter activity" EXACT [] is_a: GO:0015077 ! monovalent inorganic cation transmembrane transporter activity is_a: GO:0046873 ! metal ion transmembrane transporter activity relationship: part_of GO:0035725 ! sodium ion transmembrane transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015291 name: secondary active transmembrane transporter activity namespace: molecular_function alt_id: GO:0015290 alt_id: GO:0015353 alt_id: GO:0015404 alt_id: GO:0015570 def: "Catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729, PMID:10839820] subset: gosubset_prok synonym: "active transporter" BROAD [] synonym: "coupled carrier" EXACT [] synonym: "electrochemical potential-driven transporter activity" EXACT [] synonym: "energizer of outer membrane receptor-mediated transport activity" NARROW [] synonym: "galactose/glucose (methylgalactoside) porter activity" RELATED [] synonym: "heavy metal ion porter activity" NARROW [] synonym: "ion-gradient-driven energizer activity" NARROW [] synonym: "multidrug endosomal transmembrane transporter activity" NARROW [] synonym: "nitrite/nitrate porter activity" NARROW [] synonym: "porter activity" EXACT [] synonym: "porters" EXACT [] synonym: "secondary carrier-type facilitators" EXACT [] xref: Reactome:REACT_103382 "CoA transport across the inner mitochondrial membrane, Dictyostelium discoideum" xref: Reactome:REACT_104654 "CoA transport across the inner mitochondrial membrane, Mus musculus" xref: Reactome:REACT_105273 "CoA transport across the inner mitochondrial membrane, Schizosaccharomyces pombe" xref: Reactome:REACT_105531 "CoA transport across the inner mitochondrial membrane, Saccharomyces cerevisiae" xref: Reactome:REACT_105779 "CoA transport across the inner mitochondrial membrane, Danio rerio" xref: Reactome:REACT_110806 "CoA transport across the inner mitochondrial membrane, Sus scrofa" xref: Reactome:REACT_11209 "CoA transport across the inner mitochondrial membrane, Homo sapiens" xref: Reactome:REACT_113603 "CoA transport across the inner mitochondrial membrane, Xenopus tropicalis" xref: Reactome:REACT_114125 "CoA transport across the inner mitochondrial membrane, Oryza sativa" xref: Reactome:REACT_114308 "CoA transport across the inner mitochondrial membrane, Arabidopsis thaliana" xref: Reactome:REACT_31262 "CoA transport across the inner mitochondrial membrane, Rattus norvegicus" xref: Reactome:REACT_86944 "CoA transport across the inner mitochondrial membrane, Gallus gallus" xref: Reactome:REACT_91139 "CoA transport across the inner mitochondrial membrane, Bos taurus" xref: Reactome:REACT_94332 "CoA transport across the inner mitochondrial membrane, Taeniopygia guttata" xref: Reactome:REACT_99923 "CoA transport across the inner mitochondrial membrane, Canis familiaris" xref: TC:2.A is_a: GO:0022804 ! active transmembrane transporter activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015297 name: antiporter activity namespace: molecular_function alt_id: GO:0015300 def: "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out)." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] subset: gosubset_prok synonym: "antiport" RELATED [] synonym: "countertransporter activity" EXACT [] synonym: "exchange transporter activity" EXACT [] synonym: "exchanger" BROAD [] synonym: "porter" BROAD [] synonym: "solute:solute antiporter activity" EXACT [] synonym: "solute:solute exchange" RELATED [] is_a: GO:0015291 ! secondary active transmembrane transporter activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015298 name: solute:cation antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(in) = solute(in) + cation(out)." [GOC:ai] subset: gosubset_prok is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015297 ! antiporter activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015299 name: solute:proton antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out)." [GOC:ai] subset: gosubset_prok synonym: "L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity" NARROW [] synonym: "solute:hydrogen antiporter activity" EXACT [] is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity is_a: GO:0015298 ! solute:cation antiporter activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015385 name: sodium:proton antiporter activity namespace: molecular_function alt_id: GO:0015502 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [TC:2.A.35.1.1, TC:2.A.36.-.-] subset: gosubset_prok synonym: "pH-dependent sodium:hydrogen antiporter activity" NARROW [] synonym: "pH-dependent sodium:proton antiporter activity" NARROW [] synonym: "sodium/hydrogen antiporter activity" EXACT [] synonym: "sodium:hydrogen antiporter activity" EXACT [] synonym: "sodium:hydrogen exchange activity" EXACT [] synonym: "sodium:hydrogen exchanger" EXACT [] xref: Reactome:REACT_100313 "Na+/H+ exchanger transport (at cell membrane), Canis familiaris" xref: Reactome:REACT_100581 "Na+/H+ exchanger transport (at trans-golgi membrane), Arabidopsis thaliana" xref: Reactome:REACT_100724 "Na+/H+ exchanger transport (at cell membrane), Mycobacterium tuberculosis" xref: Reactome:REACT_101156 "Na+/H+ exchanger transport (at late endosome membrane), Oryza sativa" xref: Reactome:REACT_102032 "Na+/H+ exchanger transport (at late endosome membrane), Gallus gallus" xref: Reactome:REACT_102112 "Na+/H+ exchanger transport (at late endosome membrane), Escherichia coli" xref: Reactome:REACT_102864 "Na+/H+ exchanger transport (at trans-golgi membrane), Mus musculus" xref: Reactome:REACT_102894 "Na+/H+ exchanger transport (at trans-golgi membrane), Oryza sativa" xref: Reactome:REACT_105719 "Na+/H+ exchanger transport (at trans-golgi membrane), Staphylococcus aureus N315" xref: Reactome:REACT_106807 "Na+/H+ exchanger transport (at cell membrane), Gallus gallus" xref: Reactome:REACT_107375 "Na+/H+ exchanger transport (at cell membrane), Sus scrofa" xref: Reactome:REACT_107865 "Na+/H+ exchanger transport (at early endosome membrane), Bos taurus" xref: Reactome:REACT_108868 "Na+/H+ exchanger transport (at late endosome membrane), Taeniopygia guttata" xref: Reactome:REACT_109095 "Na+/H+ exchanger transport (at early endosome membrane), Drosophila melanogaster" xref: Reactome:REACT_109433 "Na+/H+ exchanger transport (at late endosome membrane), Staphylococcus aureus N315" xref: Reactome:REACT_110267 "Na+/H+ exchanger transport (at early endosome membrane), Caenorhabditis elegans" xref: Reactome:REACT_110836 "Na+/H+ exchanger transport (at cell membrane), Mus musculus" xref: Reactome:REACT_110863 "Na+/H+ exchanger transport (at cell membrane), Xenopus tropicalis" xref: Reactome:REACT_112054 "Na+/H+ exchanger transport (at early endosome membrane), Gallus gallus" xref: Reactome:REACT_19218 "Na+/H+ exchanger transport (at trans-golgi membrane), Homo sapiens" xref: Reactome:REACT_19224 "Na+/H+ exchanger transport (at cell membrane), Homo sapiens" xref: Reactome:REACT_19253 "Na+/H+ exchanger transport (at early endosome membrane), Homo sapiens" xref: Reactome:REACT_19303 "Na+/H+ exchanger transport (at late endosome membrane), Homo sapiens" xref: Reactome:REACT_28080 "Na+/H+ exchanger transport (at late endosome membrane), Saccharomyces cerevisiae" xref: Reactome:REACT_28922 "Na+/H+ exchanger transport (at late endosome membrane), Schizosaccharomyces pombe" xref: Reactome:REACT_30436 "Na+/H+ exchanger transport (at trans-golgi membrane), Danio rerio" xref: Reactome:REACT_30713 "Na+/H+ exchanger transport (at early endosome membrane), Danio rerio" xref: Reactome:REACT_32407 "Na+/H+ exchanger transport (at cell membrane), Drosophila melanogaster" xref: Reactome:REACT_32466 "Na+/H+ exchanger transport (at early endosome membrane), Taeniopygia guttata" xref: Reactome:REACT_33295 "Na+/H+ exchanger transport (at late endosome membrane), Xenopus tropicalis" xref: Reactome:REACT_34009 "Na+/H+ exchanger transport (at late endosome membrane), Rattus norvegicus" xref: Reactome:REACT_34239 "Na+/H+ exchanger transport (at cell membrane), Danio rerio" xref: Reactome:REACT_48026 "Na+/H+ exchanger transport (at trans-golgi membrane), Caenorhabditis elegans" xref: Reactome:REACT_77239 "Na+/H+ exchanger transport (at trans-golgi membrane), Sus scrofa" xref: Reactome:REACT_77347 "Na+/H+ exchanger transport (at trans-golgi membrane), Mycobacterium tuberculosis" xref: Reactome:REACT_77622 "Na+/H+ exchanger transport (at early endosome membrane), Staphylococcus aureus N315" xref: Reactome:REACT_77750 "Na+/H+ exchanger transport (at late endosome membrane), Caenorhabditis elegans" xref: Reactome:REACT_78497 "Na+/H+ exchanger transport (at early endosome membrane), Schizosaccharomyces pombe" xref: Reactome:REACT_78841 "Na+/H+ exchanger transport (at cell membrane), Taeniopygia guttata" xref: Reactome:REACT_80328 "Na+/H+ exchanger transport (at early endosome membrane), Canis familiaris" xref: Reactome:REACT_80427 "Na+/H+ exchanger transport (at trans-golgi membrane), Drosophila melanogaster" xref: Reactome:REACT_81164 "Na+/H+ exchanger transport (at late endosome membrane), Mus musculus" xref: Reactome:REACT_81214 "Na+/H+ exchanger transport (at early endosome membrane), Mus musculus" xref: Reactome:REACT_81645 "Na+/H+ exchanger transport (at trans-golgi membrane), Taeniopygia guttata" xref: Reactome:REACT_83014 "Na+/H+ exchanger transport (at late endosome membrane), Arabidopsis thaliana" xref: Reactome:REACT_83758 "Na+/H+ exchanger transport (at late endosome membrane), Sus scrofa" xref: Reactome:REACT_84369 "Na+/H+ exchanger transport (at late endosome membrane), Drosophila melanogaster" xref: Reactome:REACT_85599 "Na+/H+ exchanger transport (at early endosome membrane), Sus scrofa" xref: Reactome:REACT_86696 "Na+/H+ exchanger transport (at early endosome membrane), Mycobacterium tuberculosis" xref: Reactome:REACT_87561 "Na+/H+ exchanger transport (at trans-golgi membrane), Gallus gallus" xref: Reactome:REACT_89780 "Na+/H+ exchanger transport (at trans-golgi membrane), Bos taurus" xref: Reactome:REACT_90215 "Na+/H+ exchanger transport (at trans-golgi membrane), Canis familiaris" xref: Reactome:REACT_90329 "Na+/H+ exchanger transport (at early endosome membrane), Xenopus tropicalis" xref: Reactome:REACT_91466 "Na+/H+ exchanger transport (at early endosome membrane), Saccharomyces cerevisiae" xref: Reactome:REACT_92179 "Na+/H+ exchanger transport (at cell membrane), Escherichia coli" xref: Reactome:REACT_92386 "Na+/H+ exchanger transport (at late endosome membrane), Mycobacterium tuberculosis" xref: Reactome:REACT_92389 "Na+/H+ exchanger transport (at trans-golgi membrane), Schizosaccharomyces pombe" xref: Reactome:REACT_92390 "Na+/H+ exchanger transport (at early endosome membrane), Oryza sativa" xref: Reactome:REACT_92820 "Na+/H+ exchanger transport (at trans-golgi membrane), Saccharomyces cerevisiae" xref: Reactome:REACT_93564 "Na+/H+ exchanger transport (at early endosome membrane), Escherichia coli" xref: Reactome:REACT_94624 "Na+/H+ exchanger transport (at late endosome membrane), Canis familiaris" xref: Reactome:REACT_94723 "Na+/H+ exchanger transport (at trans-golgi membrane), Rattus norvegicus" xref: Reactome:REACT_95936 "Na+/H+ exchanger transport (at cell membrane), Rattus norvegicus" xref: Reactome:REACT_96090 "Na+/H+ exchanger transport (at cell membrane), Caenorhabditis elegans" xref: Reactome:REACT_96181 "Na+/H+ exchanger transport (at early endosome membrane), Arabidopsis thaliana" xref: Reactome:REACT_96627 "Na+/H+ exchanger transport (at trans-golgi membrane), Escherichia coli" xref: Reactome:REACT_96669 "Na+/H+ exchanger transport (at cell membrane), Staphylococcus aureus N315" xref: Reactome:REACT_97077 "Na+/H+ exchanger transport (at late endosome membrane), Bos taurus" xref: Reactome:REACT_97109 "Na+/H+ exchanger transport (at trans-golgi membrane), Dictyostelium discoideum" xref: Reactome:REACT_98020 "Na+/H+ exchanger transport (at trans-golgi membrane), Xenopus tropicalis" xref: Reactome:REACT_99016 "Na+/H+ exchanger transport (at cell membrane), Bos taurus" xref: Reactome:REACT_99336 "Na+/H+ exchanger transport (at early endosome membrane), Rattus norvegicus" xref: RHEA:29254 is_a: GO:0005451 ! monovalent cation:proton antiporter activity is_a: GO:0015081 ! sodium ion transmembrane transporter activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015399 name: primary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute from one side of the membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is powered by a primary energy source, directly using ATP. Primary energy sources known to be coupled to transport are chemical, electrical and solar sources." [GOC:mtg_transport, ISBN:0815340729, TC:3.-.-.-.-] subset: gosubset_prok synonym: "primary active transporter" RELATED [] xref: TC:3 is_a: GO:0022804 ! active transmembrane transporter activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015405 name: P-P-bond-hydrolysis-driven transmembrane transporter activity namespace: molecular_function def: "Primary active transport of a solute across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.A.-.-.-] subset: gosubset_prok synonym: "P-P-bond-hydrolysis-driven transporters" EXACT [] xref: TC:3.A is_a: GO:0015399 ! primary active transmembrane transporter activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015491 name: cation:cation antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation A(out) + cation B(in) = cation A(in) + cation B(out)." [GOC:ai] subset: gosubset_prok is_a: GO:0015298 ! solute:cation antiporter activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015629 name: actin cytoskeleton namespace: cellular_component def: "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194] subset: goslim_aspergillus is_a: GO:0005856 ! cytoskeleton property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015630 name: microtubule cytoskeleton namespace: cellular_component def: "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] subset: goslim_aspergillus is_a: GO:0005856 ! cytoskeleton property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015631 name: tubulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt] is_a: GO:0008092 ! cytoskeletal protein binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015645 name: fatty acid ligase activity namespace: molecular_function def: "Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP." [EC:6.2.1.20, EC:6.2.1.3, GOC:cjk, GOC:mah] subset: gosubset_prok synonym: "acid:CoA ligase (AMP-forming) activity" EXACT [EC:6.2.1.3] synonym: "acyl coenzyme A synthetase activity" EXACT [EC:6.2.1.3] synonym: "acyl-coenzyme A ligase activity" EXACT [EC:6.2.1.3] synonym: "fatty acid CoA ligase activity" EXACT [EC:6.2.1.3] synonym: "fatty acyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.3] synonym: "fatty-acid ligase activity" EXACT [] xref: EC:6.2.1.- is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015672 name: monovalent inorganic cation transport namespace: biological_process def: "The directed movement of inorganic cations with a valency of one into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage." [GOC:ai] subset: gosubset_prok is_a: GO:0006812 ! cation transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015675 name: nickel cation transport namespace: biological_process def: "The directed movement of nickel (Ni) cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0000041 ! transition metal ion transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015677 name: copper ion import namespace: biological_process def: "The directed movement of copper ions into a cell or organelle." [GOC:ai] synonym: "copper ion uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0006825 ! copper ion transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015682 name: ferric iron transport namespace: biological_process def: "The directed movement of ferric iron (Fe(III) or Fe3+) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "ferric ion transport" EXACT [] is_a: GO:0006826 ! iron ion transport is_a: GO:0072512 ! trivalent inorganic cation transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015684 name: ferrous iron transport namespace: biological_process def: "The directed movement of ferrous iron (Fe(II) or Fe2+) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "ferrous ion transport" EXACT [] is_a: GO:0006826 ! iron ion transport is_a: GO:0070838 ! divalent metal ion transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015691 name: cadmium ion transport namespace: biological_process def: "The directed movement of cadmium (Cd) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "cadmium transport" EXACT [] is_a: GO:0000041 ! transition metal ion transport is_a: GO:0070838 ! divalent metal ion transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015698 name: inorganic anion transport namespace: biological_process def: "The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage." [GOC:krc] subset: gosubset_prok is_a: GO:0006820 ! anion transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015711 name: organic anion transport namespace: biological_process def: "The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai, GOC:krc] subset: gosubset_prok is_a: GO:0006820 ! anion transport is_a: GO:0071702 ! organic substance transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015718 name: monocarboxylic acid transport namespace: biological_process def: "The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok is_a: GO:0046942 ! carboxylic acid transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015740 name: C4-dicarboxylate transport namespace: biological_process def: "The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms." [GOC:krc, GOC:mah] subset: gosubset_prok is_a: GO:0006835 ! dicarboxylic acid transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015743 name: malate transport namespace: biological_process def: "The directed movement of malate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "mitochondrial alpha-ketoglutarate/malate transport" RELATED [] is_a: GO:0015740 ! C4-dicarboxylate transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015744 name: succinate transport namespace: biological_process def: "The directed movement of succinate, the dianion of ethane dicarboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok is_a: GO:0015740 ! C4-dicarboxylate transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015748 name: organophosphate ester transport namespace: biological_process def: "The directed movement of organophosphate esters into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organophosphate esters are small organic molecules containing phosphate ester bonds." [GOC:mcc] is_a: GO:0044765 ! single-organism transport is_a: GO:0071702 ! organic substance transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015749 name: monosaccharide transport namespace: biological_process def: "The directed movement of monosaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GOC:ai] subset: gosubset_prok is_a: GO:0008643 ! carbohydrate transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015758 name: glucose transport namespace: biological_process def: "The directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok xref: Reactome:REACT_100748 "Glucose transport, Schizosaccharomyces pombe" xref: Reactome:REACT_104861 "Glucose transport, Canis familiaris" xref: Reactome:REACT_106782 "Glucose transport, Bos taurus" xref: Reactome:REACT_112521 "Glucose transport, Dictyostelium discoideum" xref: Reactome:REACT_114803 "Glucose transport, Mycobacterium tuberculosis" xref: Reactome:REACT_115616 "Glucose transport, Gallus gallus" xref: Reactome:REACT_212 "Glucose transport, Homo sapiens" xref: Reactome:REACT_29233 "Glucose transport, Saccharomyces cerevisiae" xref: Reactome:REACT_29527 "Glucose transport, Gallus gallus" xref: Reactome:REACT_31046 "Glucose transport, Mus musculus" xref: Reactome:REACT_34463 "Glucose transport, Drosophila melanogaster" xref: Reactome:REACT_77150 "Glucose transport, Caenorhabditis elegans" xref: Reactome:REACT_79237 "Glucose transport, Sus scrofa" xref: Reactome:REACT_79607 "Glucose transport, Plasmodium falciparum" xref: Reactome:REACT_83707 "Glucose transport, Xenopus tropicalis" xref: Reactome:REACT_89807 "Glucose transport, Danio rerio" xref: Reactome:REACT_94026 "Glucose transport, Arabidopsis thaliana" xref: Reactome:REACT_97809 "Glucose transport, Rattus norvegicus" xref: Reactome:REACT_98004 "Glucose transport, Oryza sativa" xref: Reactome:REACT_98234 "Glucose transport, Taeniopygia guttata" is_a: GO:0008645 ! hexose transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015780 name: nucleotide-sugar transport namespace: biological_process def: "The directed movement of nucleotide-sugars into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732] is_a: GO:0006862 ! nucleotide transport is_a: GO:1901264 ! carbohydrate derivative transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015781 name: pyrimidine nucleotide-sugar transport namespace: biological_process def: "The directed movement of pyrimidine nucleotide-sugars into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai] is_a: GO:0015780 ! nucleotide-sugar transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015785 name: UDP-galactose transport namespace: biological_process def: "The directed movement of UDP-galactose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate." [GOC:ai] is_a: GO:0015711 ! organic anion transport is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015791 name: polyol transport namespace: biological_process def: "The directed movement of polyols, any polyhydric alcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir subset: gosubset_prok is_a: GO:0015850 ! organic hydroxy compound transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015798 name: myo-inositol transport namespace: biological_process def: "The directed movement of myo-inositol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms." [GOC:ai] subset: gosubset_prok synonym: "vitamin Bh transport" EXACT [] is_a: GO:0015791 ! polyol transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015800 name: acidic amino acid transport namespace: biological_process def: "The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0006865 ! amino acid transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015801 name: aromatic amino acid transport namespace: biological_process def: "The directed movement of aromatic amino acids, amino acids with aromatic ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0006865 ! amino acid transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015802 name: basic amino acid transport namespace: biological_process def: "The directed movement of basic amino acids, amino acids with a pH above 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0006865 ! amino acid transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015803 name: branched-chain amino acid transport namespace: biological_process alt_id: GO:1900755 def: "The directed movement of branched-chain amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings." [CHEBI:22918, GOC:ai, GOC:bf] subset: gosubset_prok synonym: "branched-chain aliphatic amino acid transport" EXACT [GOC:curators] synonym: "branched-chain amino-acid anion transport" EXACT [GOC:jl] synonym: "branched-chain amino-acid anions transport" RELATED [GOC:TermGenie] is_a: GO:0006865 ! amino acid transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015804 name: neutral amino acid transport namespace: biological_process def: "The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0006865 ! amino acid transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015807 name: L-amino acid transport namespace: biological_process def: "The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah] subset: gosubset_prok is_a: GO:0006865 ! amino acid transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015809 name: arginine transport namespace: biological_process def: "The directed movement of arginine, 2-amino-5-guanidinopentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732] subset: gosubset_prok synonym: "L-arginine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015802 ! basic amino acid transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015813 name: L-glutamate transport namespace: biological_process def: "The directed movement of L-glutamate, the L enantiomer anion of 2-aminopentanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:dph, GOC:tb] subset: gosubset_prok synonym: "mitochondrial aspartate/glutamate transport" RELATED [] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0015800 ! acidic amino acid transport is_a: GO:0015807 ! L-amino acid transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015816 name: glycine transport namespace: biological_process def: "The directed movement of glycine, aminoethanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0006812 ! cation transport is_a: GO:0015804 ! neutral amino acid transport is_a: GO:0015807 ! L-amino acid transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015817 name: histidine transport namespace: biological_process def: "The directed movement of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "L-histidine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015802 ! basic amino acid transport is_a: GO:0045117 ! azole transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015818 name: isoleucine transport namespace: biological_process def: "The directed movement of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "L-isoleucine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015803 ! branched-chain amino acid transport is_a: GO:0015804 ! neutral amino acid transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015819 name: lysine transport namespace: biological_process def: "The directed movement of lysine, 2,6-diaminohexanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "L-lysine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015802 ! basic amino acid transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015820 name: leucine transport namespace: biological_process def: "The directed movement of leucine, 2-amino-4-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "L-leucine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015803 ! branched-chain amino acid transport is_a: GO:0015804 ! neutral amino acid transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015821 name: methionine transport namespace: biological_process def: "The directed movement of methionine, 2-amino-4-(methylthio)butanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "L-methionine transport" NARROW [] is_a: GO:0000101 ! sulfur amino acid transport is_a: GO:0006812 ! cation transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015824 name: proline transport namespace: biological_process def: "The directed movement of proline, pyrrolidine-2-carboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "L-proline transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015804 ! neutral amino acid transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015825 name: L-serine transport namespace: biological_process def: "The directed movement of L-serine, the L-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah] subset: gosubset_prok is_a: GO:0015807 ! L-amino acid transport is_a: GO:0032329 ! serine transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015826 name: threonine transport namespace: biological_process def: "The directed movement of threonine, (2R*,3S*)-2-amino-3-hydroxybutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "L-threonine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015804 ! neutral amino acid transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015828 name: tyrosine transport namespace: biological_process def: "The directed movement of tyrosine, 2-amino-3-(4-hydroxyphenyl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "L-tyrosine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015801 ! aromatic amino acid transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015829 name: valine transport namespace: biological_process def: "The directed movement of valine, 2-amino-3-methylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "L-valine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015803 ! branched-chain amino acid transport is_a: GO:0015804 ! neutral amino acid transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015849 name: organic acid transport namespace: biological_process def: "The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732] subset: goslim_pir subset: gosubset_prok is_a: GO:0044765 ! single-organism transport is_a: GO:0071702 ! organic substance transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015850 name: organic hydroxy compound transport namespace: biological_process def: "The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom." [CHEBI:33822, GOC:ai] subset: gosubset_prok synonym: "organic alcohol transport" EXACT [CHEBI:33822] is_a: GO:0044765 ! single-organism transport is_a: GO:0071702 ! organic substance transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015851 name: nucleobase transport namespace: biological_process def: "The directed movement of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732] subset: gosubset_prok synonym: "nucleobase transmembrane transport" EXACT [GOC:mah] is_a: GO:0044765 ! single-organism transport is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015853 name: adenine transport namespace: biological_process def: "The directed movement of adenine, 6-aminopurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732] synonym: "adenine transmembrane transport" EXACT [GOC:mah] is_a: GO:0006863 ! purine nucleobase transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015854 name: guanine transport namespace: biological_process def: "The directed movement of guanine, 2-amino-6-hydroxypurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] synonym: "guanine transmembrane transport" EXACT [GOC:mah] is_a: GO:0006863 ! purine nucleobase transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015878 name: biotin transport namespace: biological_process def: "The directed movement of biotin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:ai] synonym: "vitamin B7 transport" EXACT [] synonym: "vitamin H transport" EXACT [] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0042886 ! amide transport is_a: GO:0051180 ! vitamin transport is_a: GO:0051181 ! cofactor transport is_a: GO:0072348 ! sulfur compound transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015925 name: galactosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative." [GOC:ai] subset: gosubset_prok xref: EC:3.2.1.- is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015926 name: glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative." [ISBN:0198506732] subset: gosubset_prok xref: EC:3.2.1.- is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015927 name: trehalase activity namespace: molecular_function def: "Catalysis of the hydrolysis of trehalose or a trehalose derivative." [GOC:ai] subset: gosubset_prok xref: EC:3.2.1.- xref: MetaCyc:TREHALA-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015931 name: nucleobase-containing compound transport namespace: biological_process def: "The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb] is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015934 name: large ribosomal subunit namespace: cellular_component def: "The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732] subset: gosubset_prok synonym: "ribosomal large subunit" EXACT [] is_a: GO:0044391 ! ribosomal subunit property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015935 name: small ribosomal subunit namespace: cellular_component def: "The smaller of the two subunits of a ribosome." [GOC:mah] subset: goslim_pir subset: gosubset_prok synonym: "ribosomal small subunit" EXACT [] is_a: GO:0044391 ! ribosomal subunit property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015980 name: energy derivation by oxidation of organic compounds namespace: biological_process def: "The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released." [GOC:mah] subset: gosubset_prok synonym: "chemoorganotrophy" EXACT [] is_a: GO:0006091 ! generation of precursor metabolites and energy is_a: GO:0044763 ! single-organism cellular process is_a: GO:0055114 ! oxidation-reduction process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015985 name: energy coupled proton transport, down electrochemical gradient namespace: biological_process def: "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that provides energy for the synthesis of ATP or GTP." [GOC:mah] subset: gosubset_prok is_a: GO:1902600 ! hydrogen ion transmembrane transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015986 name: ATP synthesis coupled proton transport namespace: biological_process def: "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363] subset: gosubset_prok synonym: "chemiosmosis" BROAD [GOC:rs] is_a: GO:0006754 ! ATP biosynthetic process is_a: GO:0015985 ! energy coupled proton transport, down electrochemical gradient property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0015992 name: proton transport namespace: biological_process def: "The directed movement of protons (hydrogen ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] subset: gosubset_prok synonym: "hydrogen ion transport" EXACT [] synonym: "passive proton transport, down the electrochemical gradient" NARROW [] xref: Reactome:REACT_100717 "The proton buffering model, Gallus gallus" xref: Reactome:REACT_102006 "Mitochondrial Uncoupling Proteins, Xenopus tropicalis" xref: Reactome:REACT_103123 "Mitochondrial Uncoupling Proteins, Mus musculus" xref: Reactome:REACT_104490 "Mitochondrial Uncoupling Proteins, Arabidopsis thaliana" xref: Reactome:REACT_105995 "Mitochondrial Uncoupling Proteins, Gallus gallus" xref: Reactome:REACT_106176 "Mitochondrial Uncoupling Proteins, Canis familiaris" xref: Reactome:REACT_106794 "The proton buffering model, Arabidopsis thaliana" xref: Reactome:REACT_110839 "Mitochondrial Uncoupling Proteins, Bos taurus" xref: Reactome:REACT_29555 "The proton buffering model, Canis familiaris" xref: Reactome:REACT_30770 "Mitochondrial Uncoupling Proteins, Taeniopygia guttata" xref: Reactome:REACT_31883 "The proton buffering model, Xenopus tropicalis" xref: Reactome:REACT_6196 "The proton buffering model, Homo sapiens" xref: Reactome:REACT_6341 "Mitochondrial Uncoupling Proteins, Homo sapiens" xref: Reactome:REACT_77530 "Mitochondrial Uncoupling Proteins, Oryza sativa" xref: Reactome:REACT_80235 "The proton buffering model, Oryza sativa" xref: Reactome:REACT_82088 "The proton buffering model, Sus scrofa" xref: Reactome:REACT_83467 "Mitochondrial Uncoupling Proteins, Sus scrofa" xref: Reactome:REACT_88310 "The proton buffering model, Rattus norvegicus" xref: Reactome:REACT_89771 "The proton buffering model, Taeniopygia guttata" xref: Reactome:REACT_90272 "The proton buffering model, Danio rerio" xref: Reactome:REACT_92912 "Mitochondrial Uncoupling Proteins, Danio rerio" xref: Reactome:REACT_92975 "The proton buffering model, Bos taurus" xref: Reactome:REACT_94505 "Mitochondrial Uncoupling Proteins, Rattus norvegicus" xref: Reactome:REACT_95151 "The proton buffering model, Mus musculus" is_a: GO:0006818 ! hydrogen transport is_a: GO:0015672 ! monovalent inorganic cation transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016002 name: sulfite reductase activity namespace: molecular_function def: "Catalysis of the reaction: hydrogen sulfide + acceptor + 3 H2O = sulfite + reduced acceptor." [EC:1.8.99.1] subset: gosubset_prok synonym: "assimilatory sulfite reductase activity" EXACT [EC:1.8.99.1] synonym: "assimilatory-type sulfite reductase activity" EXACT [EC:1.8.99.1] synonym: "hydrogen-sulfide:(acceptor) oxidoreductase activity" EXACT [EC:1.8.99.1] synonym: "hydrogen-sulfide:acceptor oxidoreductase activity" EXACT [EC:1.8.99.1] synonym: "siroheme sulfite reductase activity" NARROW [MetaCyc:SULFITE-REDUCTASE-RXN] synonym: "sulphite reductase activity" EXACT [] xref: EC:1.8.99.1 xref: MetaCyc:SULFITE-REDUCTASE-RXN xref: RHEA:10547 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016018 name: cyclosporin A binding namespace: molecular_function def: "Interacting selectively and non-covalently with cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids." [GOC:mb] synonym: "cyclophilin" RELATED [] is_a: GO:0008144 ! drug binding is_a: GO:0042277 ! peptide binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016020 name: membrane namespace: cellular_component def: "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: Wikipedia:Biological_membrane is_a: GO:0005575 ! cellular_component property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016021 name: integral component of membrane namespace: cellular_component def: "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] subset: goslim_chembl subset: gosubset_prok synonym: "integral to membrane" NARROW [] synonym: "transmembrane" RELATED [GOC:mah] xref: Wikipedia:Transmembrane_protein is_a: GO:0031224 ! intrinsic component of membrane property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016023 name: cytoplasmic membrane-bounded vesicle namespace: cellular_component def: "A membrane-bounded vesicle found in the cytoplasm of the cell." [GOC:ai, GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_yeast subset: gosubset_prok synonym: "cytoplasmic membrane bounded vesicle" EXACT [] synonym: "cytoplasmic membrane-enclosed vesicle" EXACT [] is_a: GO:0031410 ! cytoplasmic vesicle is_a: GO:0031988 ! membrane-bounded vesicle is_a: GO:0043231 ! intracellular membrane-bounded organelle intersection_of: GO:0031988 ! membrane-bounded vesicle intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005737 ! cytoplasm property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016036 name: cellular response to phosphate starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate." [GOC:jl] subset: gosubset_prok is_a: GO:0009267 ! cellular response to starvation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016043 name: cellular component organization namespace: biological_process alt_id: GO:0044235 alt_id: GO:0071842 def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah] subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "cell organisation" EXACT [] synonym: "cell organization and biogenesis" RELATED [GOC:mah] synonym: "cellular component organisation at cellular level" EXACT [GOC:mah] synonym: "cellular component organisation in other organism" EXACT [GOC:mah] synonym: "cellular component organization at cellular level" EXACT [] synonym: "cellular component organization in other organism" EXACT [] is_a: GO:0009987 ! cellular process is_a: GO:0071840 ! cellular component organization or biogenesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016049 name: cell growth namespace: biological_process alt_id: GO:0048591 def: "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai] subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "cell expansion" RELATED [] synonym: "cellular growth" EXACT [] synonym: "growth of cell" EXACT [] synonym: "metabolic process resulting in cell growth" RELATED [] synonym: "metabolism resulting in cell growth" RELATED [] synonym: "non-developmental cell growth" RELATED [GOC:mah] synonym: "non-developmental growth of a unicellular organism" RELATED [GOC:mah] is_a: GO:0040007 ! growth is_a: GO:0044763 ! single-organism cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016051 name: carbohydrate biosynthetic process namespace: biological_process alt_id: GO:0006093 def: "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732] subset: gosubset_prok synonym: "anabolic carbohydrate metabolic process" EXACT [] synonym: "anabolic carbohydrate metabolism" EXACT [] synonym: "carbohydrate anabolism" EXACT [] synonym: "carbohydrate biosynthesis" EXACT [] synonym: "carbohydrate formation" EXACT [] synonym: "carbohydrate synthesis" EXACT [] is_a: GO:0044711 ! single-organism biosynthetic process is_a: GO:0044723 ! single-organism carbohydrate metabolic process is_a: GO:1901576 ! organic substance biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016052 name: carbohydrate catabolic process namespace: biological_process alt_id: GO:0006095 def: "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732] subset: gosubset_prok synonym: "carbohydrate breakdown" EXACT [] synonym: "carbohydrate catabolism" EXACT [] synonym: "carbohydrate degradation" EXACT [] synonym: "catabolic carbohydrate metabolic process" EXACT [] synonym: "catabolic carbohydrate metabolism" EXACT [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:1901575 ! organic substance catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016053 name: organic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] subset: gosubset_prok synonym: "organic acid anabolism" EXACT [] synonym: "organic acid biosynthesis" EXACT [] synonym: "organic acid formation" EXACT [] synonym: "organic acid synthesis" EXACT [] is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0044283 ! small molecule biosynthetic process is_a: GO:1901576 ! organic substance biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016054 name: organic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] subset: gosubset_prok synonym: "organic acid breakdown" EXACT [] synonym: "organic acid catabolism" EXACT [] synonym: "organic acid degradation" EXACT [] is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:0044282 ! small molecule catabolic process is_a: GO:1901575 ! organic substance catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016070 name: RNA metabolic process namespace: biological_process def: "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_metagenomics subset: goslim_pir subset: gosubset_prok synonym: "RNA metabolism" EXACT [] xref: Reactome:REACT_107259 "Metabolism of RNA, Sus scrofa" xref: Reactome:REACT_107652 "Metabolism of RNA, Schizosaccharomyces pombe" xref: Reactome:REACT_110289 "Metabolism of RNA, Danio rerio" xref: Reactome:REACT_21257 "Metabolism of RNA, Homo sapiens" xref: Reactome:REACT_30579 "Metabolism of RNA, Xenopus tropicalis" xref: Reactome:REACT_31367 "Metabolism of RNA, Dictyostelium discoideum" xref: Reactome:REACT_33720 "Metabolism of RNA, Plasmodium falciparum" xref: Reactome:REACT_80071 "Metabolism of RNA, Caenorhabditis elegans" xref: Reactome:REACT_83630 "Metabolism of RNA, Taeniopygia guttata" xref: Reactome:REACT_84169 "Metabolism of RNA, Canis familiaris" xref: Reactome:REACT_85788 "Metabolism of RNA, Oryza sativa" xref: Reactome:REACT_88316 "Metabolism of RNA, Mus musculus" xref: Reactome:REACT_89992 "Metabolism of RNA, Saccharomyces cerevisiae" xref: Reactome:REACT_91556 "Metabolism of RNA, Bos taurus" xref: Reactome:REACT_92152 "Metabolism of RNA, Drosophila melanogaster" xref: Reactome:REACT_94876 "Metabolism of RNA, Arabidopsis thaliana" xref: Reactome:REACT_99403 "Metabolism of RNA, Rattus norvegicus" xref: Reactome:REACT_99885 "Metabolism of RNA, Gallus gallus" is_a: GO:0044260 ! cellular macromolecule metabolic process is_a: GO:0090304 ! nucleic acid metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016071 name: mRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] subset: goslim_pombe subset: gosubset_prok synonym: "mRNA metabolism" EXACT [] xref: Reactome:REACT_100536 "Metabolism of mRNA, Dictyostelium discoideum" xref: Reactome:REACT_107604 "Metabolism of mRNA, Danio rerio" xref: Reactome:REACT_108700 "Metabolism of mRNA, Rattus norvegicus" xref: Reactome:REACT_109292 "Metabolism of mRNA, Drosophila melanogaster" xref: Reactome:REACT_109673 "Metabolism of mRNA, Canis familiaris" xref: Reactome:REACT_109919 "Metabolism of mRNA, Gallus gallus" xref: Reactome:REACT_20605 "Metabolism of mRNA, Homo sapiens" xref: Reactome:REACT_28293 "Metabolism of mRNA, Sus scrofa" xref: Reactome:REACT_29287 "Metabolism of mRNA, Xenopus tropicalis" xref: Reactome:REACT_31547 "Metabolism of mRNA, Plasmodium falciparum" xref: Reactome:REACT_32511 "Metabolism of mRNA, Arabidopsis thaliana" xref: Reactome:REACT_33798 "Metabolism of mRNA, Bos taurus" xref: Reactome:REACT_33846 "Metabolism of mRNA, Mus musculus" xref: Reactome:REACT_34551 "Metabolism of mRNA, Oryza sativa" xref: Reactome:REACT_78090 "Metabolism of mRNA, Caenorhabditis elegans" xref: Reactome:REACT_84825 "Metabolism of mRNA, Taeniopygia guttata" xref: Reactome:REACT_87161 "Metabolism of mRNA, Schizosaccharomyces pombe" xref: Reactome:REACT_98319 "Metabolism of mRNA, Saccharomyces cerevisiae" is_a: GO:0016070 ! RNA metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016072 name: rRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes." [ISBN:0198506732] subset: gosubset_prok synonym: "rRNA metabolism" EXACT [] is_a: GO:0034660 ! ncRNA metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016073 name: snRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving snRNA, small nuclear RNA, any of various low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein." [ISBN:0198506732] synonym: "snRNA metabolism" EXACT [] is_a: GO:0034660 ! ncRNA metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016074 name: snoRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. They participate in the processing or modifications of many RNAs, mostly ribosomal RNAs (rRNAs) though snoRNAs are also known to target other classes of RNA, including spliceosomal RNAs, tRNAs, and mRNAs via a stretch of sequence that is complementary to a sequence in the targeted RNA." [GOC:krc] subset: goslim_pombe synonym: "snoRNA metabolism" EXACT [] is_a: GO:0034660 ! ncRNA metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016125 name: sterol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [ISBN:0198547684] subset: gosubset_prok synonym: "sterol metabolism" EXACT [] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0008202 ! steroid metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016126 name: sterol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:go_curators] subset: gosubset_prok synonym: "sterol anabolism" EXACT [] synonym: "sterol biosynthesis" EXACT [] synonym: "sterol formation" EXACT [] synonym: "sterol synthesis" EXACT [] xref: MetaCyc:PWY-2541 is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0016125 ! sterol metabolic process is_a: GO:0046165 ! alcohol biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016128 name: phytosteroid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phytosteroids, steroids of higher plants that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi." [GOC:mah, ISBN:0198547684] subset: gosubset_prok synonym: "phytosteroid metabolism" EXACT [] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0008202 ! steroid metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016129 name: phytosteroid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phytosteroids, steroids that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi." [GOC:go_curators, GOC:mah, ISBN:0471331309] subset: gosubset_prok synonym: "phytosteroid anabolism" EXACT [] synonym: "phytosteroid biosynthesis" EXACT [] synonym: "phytosteroid formation" EXACT [] synonym: "phytosteroid synthesis" EXACT [] is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0016128 ! phytosteroid metabolic process is_a: GO:0046165 ! alcohol biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016174 name: NAD(P)H oxidase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide." [EC:1.6.3.1] synonym: "dual oxidase activity" RELATED [EC:1.6.3.1] synonym: "NAD(P)H:oxygen oxidoreductase activity" EXACT [EC:1.6.3.1] synonym: "NADPH oxidase" BROAD [EC:1.6.3.1] synonym: "p138tox" RELATED [EC:1.6.3.1] synonym: "ThOX activity" NARROW [EC:1.6.3.1] synonym: "THOX2 activity" NARROW [EC:1.6.3.1] synonym: "thyroid NADPH oxidase activity" NARROW [] synonym: "thyroid oxidase 2 activity" NARROW [EC:1.6.3.1] synonym: "thyroid oxidase activity" NARROW [EC:1.6.3.1] xref: EC:1.6.3.1 is_a: GO:0050664 ! oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016180 name: snRNA processing namespace: biological_process def: "Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule." [GOC:jl] is_a: GO:0016073 ! snRNA metabolic process is_a: GO:0034470 ! ncRNA processing property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016192 name: vesicle-mediated transport namespace: biological_process alt_id: GO:0006899 def: "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: gosubset_prok synonym: "nonselective vesicle transport" NARROW [] synonym: "protein sorting along secretory pathway" RELATED [] synonym: "vesicle trafficking" RELATED [] synonym: "vesicle transport" EXACT [] synonym: "vesicular transport" EXACT [GOC:mah] is_a: GO:0006810 ! transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016197 name: endosomal transport namespace: biological_process def: "The directed movement of substances into, out of, or mediated by an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation." [ISBN:0198506732] subset: goslim_yeast synonym: "endosome transport" RELATED [GOC:bf] xref: Reactome:REACT_27258 "Endosomal Sorting Complex Required For Transport (ESCRT), Homo sapiens" is_a: GO:1902582 ! single-organism intracellular transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016209 name: antioxidant activity namespace: molecular_function def: "Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732] subset: goslim_pir subset: gosubset_prok is_a: GO:0003674 ! molecular_function property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016211 name: ammonia ligase activity namespace: molecular_function def: "Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl] subset: gosubset_prok xref: EC:6.3.1.- is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016236 name: macroautophagy namespace: biological_process alt_id: GO:0034262 def: "The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane-bounded autophagic bodies which are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded." [PMID:11099404, PMID:12914914, PMID:15798367, PMID:16973210, PMID:20159618, PMID:9412464] comment: Targeted macroautophagy sometimes targets regions of cytoplasm containing non-self, such as virus particles or components (e.g. see PMID:20159618). As this is essentially the same process as macroautophagy that encloses and digests only self, the term autophagy is still used despite the enclosure of some non-self (non-auto) entities. synonym: "autophagy in response to cellular starvation" EXACT [] synonym: "non-specific autophagy" EXACT [] synonym: "starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0006914 ! autophagy is_a: GO:0009267 ! cellular response to starvation is_a: GO:0044712 ! single-organism catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016240 name: autophagosome docking namespace: biological_process def: "The initial attachment of an autophagosome membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:autophagy, GOC:mah] synonym: "autophagic vacuole docking" EXACT [GOC:autophagy] is_a: GO:0022406 ! membrane docking relationship: part_of GO:0016236 ! macroautophagy property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016265 name: death namespace: biological_process def: "A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism." [GOC:mah, GOC:mtg_apoptosis, ISBN:0877797099] comment: This term should not be used for direct manual annotation. Instead, consider selecting a child term of GO:0008219 'cell death' or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_plant subset: gosubset_prok xref: Wikipedia:Death is_a: GO:0044699 ! single-organism process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016278 name: lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue." [GOC:mah] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016279 name: protein-lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate." [PMID:12054878] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008276 ! protein methyltransferase activity is_a: GO:0016278 ! lysine N-methyltransferase activity relationship: part_of GO:0018022 ! peptidyl-lysine methylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016301 name: kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] comment: Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term. subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "phosphokinase activity" EXACT [] xref: Reactome:REACT_100073 "Activation of S6K1, Schizosaccharomyces pombe" xref: Reactome:REACT_100078 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Canis familiaris" xref: Reactome:REACT_100159 "Inactivation of Myt1 kinase, Mus musculus" xref: Reactome:REACT_100260 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Taeniopygia guttata" xref: Reactome:REACT_100298 "Phosphorylation of L1 by CK-II, Rattus norvegicus" xref: Reactome:REACT_100305 "Regulation of NUDC by phosphorylation, Caenorhabditis elegans" xref: Reactome:REACT_100311 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Canis familiaris" xref: Reactome:REACT_100390 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Canis familiaris" xref: Reactome:REACT_100465 "Phosphorylation and inactivation of eEF2K by activated S6K1, Dictyostelium discoideum" xref: Reactome:REACT_100495 "Cdc6 protein is phosphorylated by CDK, Xenopus tropicalis" xref: Reactome:REACT_100519 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Bos taurus" xref: Reactome:REACT_100636 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Canis familiaris" xref: Reactome:REACT_100637 "Phosphorylation of the Scc1:Cohesion Complex, Mus musculus" xref: Reactome:REACT_101024 "Phosphorylation and inactivation of eEF2K by activated S6K1, Bos taurus" xref: Reactome:REACT_101170 "Phosphorylation of APC component of the destruction complex, Drosophila melanogaster" xref: Reactome:REACT_101303 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Mus musculus" xref: Reactome:REACT_101431 "Mcm2-7 is phosphorylated by DDK, Danio rerio" xref: Reactome:REACT_101543 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Canis familiaris" xref: Reactome:REACT_101596 "Phosphorylation of Cyclin D:Cdk4/6 complexes, Canis familiaris" xref: Reactome:REACT_101638 "Phosphorylation and activation of CHK2 by ATM, Bos taurus" xref: Reactome:REACT_101667 "Down Regulation of Emi1 through Phosphorylation of Emi1, Bos taurus" xref: Reactome:REACT_101841 "Phosphorylation of Cdc25C at Ser216, Rattus norvegicus" xref: Reactome:REACT_101862 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Xenopus tropicalis" xref: Reactome:REACT_101914 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Xenopus tropicalis" xref: Reactome:REACT_102090 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Taeniopygia guttata" xref: Reactome:REACT_102093 "Phosphorylation and activation of eIF4G by activated S6K1, Danio rerio" xref: Reactome:REACT_102154 "Autophosphorylation of PAK-2p34 in the activation loop, Schizosaccharomyces pombe" xref: Reactome:REACT_102322 "RAF1 phosphorylates MEK2, Danio rerio" xref: Reactome:REACT_102330 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Xenopus tropicalis" xref: Reactome:REACT_102380 "Regulation of KIF23 (MKLP1) by phosphorylation, Xenopus tropicalis" xref: Reactome:REACT_102475 "Inactivation of Myt1 kinase, Rattus norvegicus" xref: Reactome:REACT_102499 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Canis familiaris" xref: Reactome:REACT_102552 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Canis familiaris" xref: Reactome:REACT_102607 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Drosophila melanogaster" xref: Reactome:REACT_102711 "Phosphorylation of L1 by CK-II, Caenorhabditis elegans" xref: Reactome:REACT_102729 "RAF1 phosphorylates MEK1, Xenopus tropicalis" xref: Reactome:REACT_102817 "Phosphorylation of L1 by ERK, Mus musculus" xref: Reactome:REACT_102887 "Mcm2-7 is phosphorylated by DDK, Rattus norvegicus" xref: Reactome:REACT_102908 "Phosphorylation of the Scc1:Cohesion Complex, Rattus norvegicus" xref: Reactome:REACT_102915 "Activation of S6K1, Arabidopsis thaliana" xref: Reactome:REACT_103060 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Arabidopsis thaliana" xref: Reactome:REACT_103291 "Phosphorylation of complexed TSC2 by PKB, Drosophila melanogaster" xref: Reactome:REACT_103327 "Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1, Rattus norvegicus" xref: Reactome:REACT_103359 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Danio rerio" xref: Reactome:REACT_103468 "Activation of Cdc25C, Drosophila melanogaster" xref: Reactome:REACT_103691 "Phosphorylation of COP1 at Ser-387 by ATM, Xenopus tropicalis" xref: Reactome:REACT_103727 "Phosphorylation of NBS1 by ATM, Drosophila melanogaster" xref: Reactome:REACT_103804 "Phosphorylation of AKT2 by PDK1, Canis familiaris" xref: Reactome:REACT_103989 "Phosphorylation of NBS1 by ATM, Danio rerio" xref: Reactome:REACT_104022 "Phosphorylation of p53 at ser-15 by ATM kinase, Xenopus tropicalis" xref: Reactome:REACT_104044 "Phosphorylation and activation of Chk1 by ATM, Sus scrofa" xref: Reactome:REACT_104109 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Danio rerio" xref: Reactome:REACT_104209 "Activation of S6K1, Caenorhabditis elegans" xref: Reactome:REACT_104323 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Rattus norvegicus" xref: Reactome:REACT_104386 "Phosphorylation and activation of eIF4B by activated S6K1, Bos taurus" xref: Reactome:REACT_104523 "Inactivation of Wee1 kinase, Bos taurus" xref: Reactome:REACT_104644 "Regulation of KIF20A (MKL2) by phosphorylation, Bos taurus" xref: Reactome:REACT_104687 "Phosphorylation of L1 by CK-II, Canis familiaris" xref: Reactome:REACT_104730 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Schizosaccharomyces pombe" xref: Reactome:REACT_104822 "Phosphorylation of COP1 at Ser-387 by ATM, Rattus norvegicus" xref: Reactome:REACT_104837 "SOS phosphorylation and dissociation (SHC), Mus musculus" xref: Reactome:REACT_104878 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Xenopus tropicalis" xref: Reactome:REACT_105254 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Danio rerio" xref: Reactome:REACT_105274 "Regulation of KIF20A (MKL2) by phosphorylation, Danio rerio" xref: Reactome:REACT_105345 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Drosophila melanogaster" xref: Reactome:REACT_105373 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Gallus gallus" xref: Reactome:REACT_105503 "Phosphorylation of L1 by ERK, Bos taurus" xref: Reactome:REACT_105561 "Phosphorylation of complexed TSC2 by PKB, Xenopus tropicalis" xref: Reactome:REACT_105569 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Xenopus tropicalis" xref: Reactome:REACT_105589 "Phosphorylation of p53 at ser-15 by ATM kinase, Canis familiaris" xref: Reactome:REACT_105664 "Akt1 phosphorylates BAD protein, Rattus norvegicus" xref: Reactome:REACT_105700 "Phosphorylation of PDE3B, Rattus norvegicus" xref: Reactome:REACT_105971 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Xenopus tropicalis" xref: Reactome:REACT_105976 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Xenopus tropicalis" xref: Reactome:REACT_106075 "Akt1 phosphorylates BAD protein, Canis familiaris" xref: Reactome:REACT_106144 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Xenopus tropicalis" xref: Reactome:REACT_106159 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Canis familiaris" xref: Reactome:REACT_106186 "Phosphorylation of TSC2 by PKB, Drosophila melanogaster" xref: Reactome:REACT_106225 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Canis familiaris" xref: Reactome:REACT_1063 "Phosphorylation of Wee1 kinase by Chk1, Schizosaccharomyces pombe" xref: Reactome:REACT_106324 "Activation of Cdc25C, Mus musculus" xref: Reactome:REACT_106383 "Phosphorylation of L1 by ERK, Xenopus tropicalis" xref: Reactome:REACT_106411 "Phosphorylation and inactivation of eEF2K by activated S6K1, Gallus gallus" xref: Reactome:REACT_106420 "Regulation of KIF23 (MKLP1) by phosphorylation, Taeniopygia guttata" xref: Reactome:REACT_106500 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Drosophila melanogaster" xref: Reactome:REACT_106505 "Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB, Rattus norvegicus" xref: Reactome:REACT_106514 "Phosphorylation of NBS1 by ATM, Mus musculus" xref: Reactome:REACT_106567 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Mus musculus" xref: Reactome:REACT_106599 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Xenopus tropicalis" xref: Reactome:REACT_106681 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Rattus norvegicus" xref: Reactome:REACT_106722 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Xenopus tropicalis" xref: Reactome:REACT_106738 "SOS phosphorylation and dissociation (IRS, Crk), Canis familiaris" xref: Reactome:REACT_106897 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Danio rerio" xref: Reactome:REACT_107009 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Arabidopsis thaliana" xref: Reactome:REACT_107055 "Phosphorylation of Cdc25C at Ser216, Bos taurus" xref: Reactome:REACT_107102 "SOS phosphorylation and dissociation (IRS, Crk), Danio rerio" xref: Reactome:REACT_107243 "Phosphorylation of APC component of the destruction complex, Mus musculus" xref: Reactome:REACT_107247 "Phosphorylation of TSC2 by PKB, Mus musculus" xref: Reactome:REACT_107310 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Danio rerio" xref: Reactome:REACT_107424 "Inactivation of Myt1 kinase, Canis familiaris" xref: Reactome:REACT_107623 "Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB, Mus musculus" xref: Reactome:REACT_107685 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Sus scrofa" xref: Reactome:REACT_107732 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Danio rerio" xref: Reactome:REACT_107736 "Phosphorylation of Cdc25C at Ser216, Sus scrofa" xref: Reactome:REACT_107787 "Phosphorylation and activation of CHK2 by ATM, Drosophila melanogaster" xref: Reactome:REACT_107849 "Phosphorylation of DLC2 by MAPK-8, Bos taurus" xref: Reactome:REACT_107854 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Canis familiaris" xref: Reactome:REACT_108002 "Plk1-mediated phosphorylation of Nlp, Bos taurus" xref: Reactome:REACT_108096 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Rattus norvegicus" xref: Reactome:REACT_108132 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Gallus gallus" xref: Reactome:REACT_108362 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Mus musculus" xref: Reactome:REACT_108394 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Danio rerio" xref: Reactome:REACT_108520 "Phosphorylation and activation of Chk1 by ATM, Danio rerio" xref: Reactome:REACT_108578 "Inactivation of Myt1 kinase, Xenopus tropicalis" xref: Reactome:REACT_108776 "Free APC/C phosphorylated by Plk1, Taeniopygia guttata" xref: Reactome:REACT_108840 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Canis familiaris" xref: Reactome:REACT_108871 "Free APC/C phosphorylated by Plk1, Mus musculus" xref: Reactome:REACT_108971 "Phosphorylation of Cyclin B1 in the CRS domain, Xenopus tropicalis" xref: Reactome:REACT_108985 "Phosphorylation of cPLA2 by ERK-2, Gallus gallus" xref: Reactome:REACT_109045 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Danio rerio" xref: Reactome:REACT_109065 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Taeniopygia guttata" xref: Reactome:REACT_109117 "Phosphorylation of 4E-BP1 by activated mTORC1, Dictyostelium discoideum" xref: Reactome:REACT_109197 "SOS phosphorylation and dissociation (IRS), Mus musculus" xref: Reactome:REACT_109244 "Inactivation of Myt1 kinase, Schizosaccharomyces pombe" xref: Reactome:REACT_109260 "Free APC/C phosphorylated by Plk1, Xenopus tropicalis" xref: Reactome:REACT_109264 "SOS phosphorylation and dissociation (IRS), Canis familiaris" xref: Reactome:REACT_109331 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Drosophila melanogaster" xref: Reactome:REACT_109367 "Phosphorylation of APC component of the destruction complex, Gallus gallus" xref: Reactome:REACT_109549 "Regulation of KIF20A (MKL2) by phosphorylation, Xenopus tropicalis" xref: Reactome:REACT_109641 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Sus scrofa" xref: Reactome:REACT_109769 "Free APC/C phosphorylated by Plk1, Gallus gallus" xref: Reactome:REACT_109799 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Mus musculus" xref: Reactome:REACT_110175 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Mus musculus" xref: Reactome:REACT_110254 "Phosphorylation of APC component of the destruction complex, Rattus norvegicus" xref: Reactome:REACT_110296 "Phosphorylation and activation of Chk1 by ATM, Schizosaccharomyces pombe" xref: Reactome:REACT_110351 "Phosphorylation and inactivation of eEF2K by activated S6K1, Canis familiaris" xref: Reactome:REACT_110382 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Oryza sativa" xref: Reactome:REACT_110530 "Down Regulation of Emi1 through Phosphorylation of Emi1, Mus musculus" xref: Reactome:REACT_110583 "Phosphorylation of DLC2 by MAPK-8, Mus musculus" xref: Reactome:REACT_110643 "Mcm2-7 is phosphorylated by DDK, Xenopus tropicalis" xref: Reactome:REACT_110679 "Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB, Danio rerio" xref: Reactome:REACT_110774 "Inactivation of Myt1 kinase, Drosophila melanogaster" xref: Reactome:REACT_110775 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Rattus norvegicus" xref: Reactome:REACT_110947 "Regulation of KIF23 (MKLP1) by phosphorylation, Drosophila melanogaster" xref: Reactome:REACT_110995 "Phosphorylation and activation of eIF4G by activated S6K1, Xenopus tropicalis" xref: Reactome:REACT_111124 "FGFR associated PI3K phosphorylates PIP2 to PIP3, Homo sapiens" xref: Reactome:REACT_111171 "FGFR-associated PI3K phosphorylates PIP2 to PIP3, Homo sapiens" xref: Reactome:REACT_1116 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Homo sapiens" xref: Reactome:REACT_111930 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Caenorhabditis elegans" xref: Reactome:REACT_1120 "Regulation of KIF20A (MKL2) by phosphorylation, Homo sapiens" xref: Reactome:REACT_112075 "Mcm2-7 is phosphorylated by DDK, Drosophila melanogaster" xref: Reactome:REACT_112101 "Phosphorylation of L1 by CK-II, Xenopus tropicalis" xref: Reactome:REACT_112156 "Phosphorylation of AKT2 by PDK1, Saccharomyces cerevisiae" xref: Reactome:REACT_112214 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Schizosaccharomyces pombe" xref: Reactome:REACT_112270 "Akt1 phosphorylates BAD protein, Xenopus tropicalis" xref: Reactome:REACT_112298 "Autophosphorylation of DNA-PKcs, Dictyostelium discoideum" xref: Reactome:REACT_112324 "Phosphorylation and activation of eIF4G by activated S6K1, Oryza sativa" xref: Reactome:REACT_112360 "Regulation of KIF23 (MKLP1) by phosphorylation, Dictyostelium discoideum" xref: Reactome:REACT_112413 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Saccharomyces cerevisiae" xref: Reactome:REACT_112480 "Inactivation of Wee1 kinase, Dictyostelium discoideum" xref: Reactome:REACT_112545 "Phosphorylation and activation of eIF4G by activated S6K1, Drosophila melanogaster" xref: Reactome:REACT_112633 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Saccharomyces cerevisiae" xref: Reactome:REACT_112709 "Phosphorylation of L1 by ERK, Saccharomyces cerevisiae" xref: Reactome:REACT_112722 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Drosophila melanogaster" xref: Reactome:REACT_112790 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Caenorhabditis elegans" xref: Reactome:REACT_112846 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Saccharomyces cerevisiae" xref: Reactome:REACT_112892 "Phosphorylation of BRCA1 at multiple sites by ATM, Oryza sativa" xref: Reactome:REACT_112948 "Autophosphorylation of DNA-PKcs, Rattus norvegicus" xref: Reactome:REACT_113022 "Phosphorylation of Cyclin B1 in the CRS domain, Schizosaccharomyces pombe" xref: Reactome:REACT_113051 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Arabidopsis thaliana" xref: Reactome:REACT_113121 "Phosphorylation and activation of eIF4B by activated S6K1, Schizosaccharomyces pombe" xref: Reactome:REACT_113227 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Saccharomyces cerevisiae" xref: Reactome:REACT_113244 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Drosophila melanogaster" xref: Reactome:REACT_113269 "Activation of S6K1, Saccharomyces cerevisiae" xref: Reactome:REACT_113435 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Oryza sativa" xref: Reactome:REACT_113527 "Autophosphorylation of DNA-PKcs, Bos taurus" xref: Reactome:REACT_113569 "Activation of Cdc25C, Saccharomyces cerevisiae" xref: Reactome:REACT_113811 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Bos taurus" xref: Reactome:REACT_113820 "Phosphorylation of Cyclin B1 in the CRS domain, Saccharomyces cerevisiae" xref: Reactome:REACT_113894 "PIP2 conversion to PIP3, Caenorhabditis elegans" xref: Reactome:REACT_113929 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Caenorhabditis elegans" xref: Reactome:REACT_113990 "Activation of Cdc25C, Schizosaccharomyces pombe" xref: Reactome:REACT_114160 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Saccharomyces cerevisiae" xref: Reactome:REACT_114198 "Phosphorylation of the Scc1:Cohesion Complex, Schizosaccharomyces pombe" xref: Reactome:REACT_114207 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Schizosaccharomyces pombe" xref: Reactome:REACT_114227 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Schizosaccharomyces pombe" xref: Reactome:REACT_114233 "Autophosphorylation of DNA-PKcs, Sus scrofa" xref: Reactome:REACT_114255 "Autophosphorylation of DNA-PKcs, Mus musculus" xref: Reactome:REACT_114268 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Schizosaccharomyces pombe" xref: Reactome:REACT_114280 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Saccharomyces cerevisiae" xref: Reactome:REACT_114319 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Caenorhabditis elegans" xref: Reactome:REACT_114323 "Activation of Cdc25C, Caenorhabditis elegans" xref: Reactome:REACT_114395 "Phosphorylation of DLC1 by MAPK 8, Xenopus tropicalis" xref: Reactome:REACT_114434 "Autophosphorylation of DNA-PKcs, Taeniopygia guttata" xref: Reactome:REACT_114461 "Phosphorylation of AKT2 by PDK1, Schizosaccharomyces pombe" xref: Reactome:REACT_114522 "Phosphorylation of BRCA1 at multiple sites by ATM, Arabidopsis thaliana" xref: Reactome:REACT_114553 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Saccharomyces cerevisiae" xref: Reactome:REACT_114599 "Phosphorylation of TSC2 by PKB, Schizosaccharomyces pombe" xref: Reactome:REACT_114624 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Drosophila melanogaster" xref: Reactome:REACT_114771 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Canis familiaris" xref: Reactome:REACT_114906 "Phosphorylation and activation of eIF4G by activated S6K1, Arabidopsis thaliana" xref: Reactome:REACT_114984 "Autophosphorylation of DNA-PKcs, Xenopus tropicalis" xref: Reactome:REACT_115006 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Caenorhabditis elegans" xref: Reactome:REACT_115135 "Phosphorylation and activation of eIF4G by activated S6K1, Dictyostelium discoideum" xref: Reactome:REACT_115168 "Autophosphorylation of DNA-PKcs, Gallus gallus" xref: Reactome:REACT_115199 "Autophosphorylation of DNA-PKcs, Canis familiaris" xref: Reactome:REACT_115358 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Drosophila melanogaster" xref: Reactome:REACT_115384 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Schizosaccharomyces pombe" xref: Reactome:REACT_115440 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Danio rerio" xref: Reactome:REACT_115472 "Phosphorylation of the SA2 Cohesin Complex, Schizosaccharomyces pombe" xref: Reactome:REACT_115475 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Schizosaccharomyces pombe" xref: Reactome:REACT_115521 "Autophosphorylation of DNA-PKcs, Danio rerio" xref: Reactome:REACT_115527 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Schizosaccharomyces pombe" xref: Reactome:REACT_115747 "Phosphorylation of H2AX at S139 by ATM at the site of DSB, Gallus gallus" xref: Reactome:REACT_116149 "Phosphorylation of RAD51 by tyrosine kinase Abelson family protein members, Gallus gallus" xref: Reactome:REACT_118137 "Phosphorylation of the Scc1:Cohesion Complex, Taeniopygia guttata" xref: Reactome:REACT_118229 "Phosphorylation of the SA2 Cohesin Complex, Taeniopygia guttata" xref: Reactome:REACT_118284 "Phosphorylation of the Scc1:Cohesion Complex, Saccharomyces cerevisiae" xref: Reactome:REACT_118307 "Phosphorylation of the SA2 Cohesin Complex, Gallus gallus" xref: Reactome:REACT_118367 "Phosphorylation of the Scc1:Cohesion Complex, Gallus gallus" xref: Reactome:REACT_118462 "Phosphorylation of the SA2 Cohesin Complex, Saccharomyces cerevisiae" xref: Reactome:REACT_1185 "Phosphorylation (Ser5) of RNA pol II CTD, Homo sapiens" xref: Reactome:REACT_1279 "Cdc6 protein is phosphorylated by CDK, Homo sapiens" xref: Reactome:REACT_128 "Phosphorylation of Cdc25C at Ser216, Homo sapiens" xref: Reactome:REACT_132 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Homo sapiens" xref: Reactome:REACT_1326 "Regulation of NUDC by phosphorylation, Homo sapiens" xref: Reactome:REACT_13431 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Homo sapiens" xref: Reactome:REACT_13581 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Oryctolagus cuniculus" xref: Reactome:REACT_1362 "Phosphorylation of the Scc1:Cohesion Complex, Homo sapiens" xref: Reactome:REACT_13817 "Autophosphorylation of PAK-2p34, Oryctolagus cuniculus" xref: Reactome:REACT_1382 "Phosphorylation of PDE3B by AKT-1, Mus musculus" xref: Reactome:REACT_13820 "Autophosphorylation of PAK-2p34 in the activation loop, Homo sapiens" xref: Reactome:REACT_1420 "SOS phosphorylation and dissociation (SHC), Homo sapiens" xref: Reactome:REACT_1481 "Phosphorylation of the SA2 Cohesin Complex, Homo sapiens" xref: Reactome:REACT_1517 "Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB, Homo sapiens" xref: Reactome:REACT_15386 "Plk1-mediated phosphorylation of Nlp, Homo sapiens" xref: Reactome:REACT_1603 "Phosphorylation and activation of CHK2 by ATM, Homo sapiens" xref: Reactome:REACT_1657 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Homo sapiens" xref: Reactome:REACT_1680 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Homo sapiens" xref: Reactome:REACT_169 "SOS phosphorylation and dissociation (IRS), Homo sapiens" xref: Reactome:REACT_1727 "RAF1 phosphorylates MEK2, Homo sapiens" xref: Reactome:REACT_1756 "Phosphorylation of p53 at ser-15 by ATM kinase, Homo sapiens" xref: Reactome:REACT_1782 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Homo sapiens" xref: Reactome:REACT_1808 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Homo sapiens" xref: Reactome:REACT_1878 "Phosphorylation of PDE3B, Homo sapiens" xref: Reactome:REACT_188 "Akt1 phosphorylates BAD protein, Homo sapiens" xref: Reactome:REACT_1888 "Phosphorylation of DLC1 by MAPK 8, Homo sapiens" xref: Reactome:REACT_1930 "Regulation of KIF23 (MKLP1) by phosphorylation, Homo sapiens" xref: Reactome:REACT_19312 "Phosphorylation of PD-1, Homo sapiens" xref: Reactome:REACT_1944 "Inactivation of Wee1 kinase, Homo sapiens" xref: Reactome:REACT_1981 "Phosphorylation of DLC2 by MAPK-8, Homo sapiens" xref: Reactome:REACT_2009 "Phosphorylation of NBS1 by ATM, Homo sapiens" xref: Reactome:REACT_203 "Raf1 phosphorylates MEK1, Rattus norvegicus" xref: Reactome:REACT_20503 "Phosphorylation of CREB by ribosomal protein S6 kinase, Homo sapiens" xref: Reactome:REACT_20543 "Phosphorylation of COP1 at Ser-387 by ATM, Homo sapiens" xref: Reactome:REACT_20562 "Phosphorylation by MAPK/ERK, Homo sapiens" xref: Reactome:REACT_20578 "Raf activation, Homo sapiens" xref: Reactome:REACT_20583 "Phosphorylation of CREB by PKA, Homo sapiens" xref: Reactome:REACT_20631 "Activation of MAPK, Homo sapiens" xref: Reactome:REACT_20640 "Phophorylation by PDK1, Homo sapiens" xref: Reactome:REACT_2066 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Homo sapiens" xref: Reactome:REACT_2111 "Orc1 is phosphorylated by cyclin A/CDK2, Homo sapiens" xref: Reactome:REACT_2119 "Activation of Cdc25C, Homo sapiens" xref: Reactome:REACT_215 "Autophosphorylation of DNA-PKcs, Homo sapiens" xref: Reactome:REACT_22099 "Phosphorylation of L1 by ERK, Homo sapiens" xref: Reactome:REACT_22378 "Phosphorylation of L1 by CK-II, Homo sapiens" xref: Reactome:REACT_23976 "Raf1 phosphorylates MEK2, Rattus norvegicus" xref: Reactome:REACT_23990 "Phosphorylation of cPLA2 by ERK-2, Homo sapiens" xref: Reactome:REACT_244 "PIP2 conversion to PIP3, Homo sapiens" xref: Reactome:REACT_26 "SOS phosphorylation and dissociation (IRS, Crk), Homo sapiens" xref: Reactome:REACT_264 "Phosphorylation of Wee1 kinase by Chk1, Homo sapiens" xref: Reactome:REACT_28054 "Phosphorylation of BRCA1 at multiple sites by ATM, Mus musculus" xref: Reactome:REACT_28091 "Inactivation of Wee1 kinase, Canis familiaris" xref: Reactome:REACT_28113 "RAF1 phosphorylates MEK1, Taeniopygia guttata" xref: Reactome:REACT_28163 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Canis familiaris" xref: Reactome:REACT_28264 "Phosphorylation of Wee1 kinase by Chk1, Arabidopsis thaliana" xref: Reactome:REACT_28480 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Danio rerio" xref: Reactome:REACT_28555 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Xenopus tropicalis" xref: Reactome:REACT_28681 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Rattus norvegicus" xref: Reactome:REACT_28719 "Phosphorylation and activation of eIF4B by activated S6K1, Xenopus tropicalis" xref: Reactome:REACT_28743 "RAF1 phosphorylates MEK2, Mus musculus" xref: Reactome:REACT_28746 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Danio rerio" xref: Reactome:REACT_28824 "Down Regulation of Emi1 through Phosphorylation of Emi1, Danio rerio" xref: Reactome:REACT_29029 "Phosphorylation of L1 by ERK, Caenorhabditis elegans" xref: Reactome:REACT_29168 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Canis familiaris" xref: Reactome:REACT_29201 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Saccharomyces cerevisiae" xref: Reactome:REACT_29213 "Activation of Cdc25C, Rattus norvegicus" xref: Reactome:REACT_29277 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Drosophila melanogaster" xref: Reactome:REACT_29284 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Xenopus tropicalis" xref: Reactome:REACT_29289 "Activation of S6K1, Gallus gallus" xref: Reactome:REACT_29300 "Phosphorylation of L1 by ERK, Drosophila melanogaster" xref: Reactome:REACT_29334 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Rattus norvegicus" xref: Reactome:REACT_29395 "Phosphorylation of AKT2 by PDK1, Xenopus tropicalis" xref: Reactome:REACT_29396 "Orc1 is phosphorylated by cyclin A/CDK2, Canis familiaris" xref: Reactome:REACT_29410 "Regulation of KIF20A (MKL2) by phosphorylation, Rattus norvegicus" xref: Reactome:REACT_29451 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Bos taurus" xref: Reactome:REACT_29588 "Phosphorylation of 4E-BP1 by activated mTORC1, Taeniopygia guttata" xref: Reactome:REACT_29614 "Regulation of NUDC by phosphorylation, Rattus norvegicus" xref: Reactome:REACT_29689 "Cdc6 protein is phosphorylated by CDK, Bos taurus" xref: Reactome:REACT_29694 "Phosphorylation of PDE3B, Canis familiaris" xref: Reactome:REACT_29759 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Bos taurus" xref: Reactome:REACT_29788 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Xenopus tropicalis" xref: Reactome:REACT_29873 "Phosphorylation of APC component of the destruction complex, Taeniopygia guttata" xref: Reactome:REACT_29914 "Down Regulation of Emi1 through Phosphorylation of Emi1, Canis familiaris" xref: Reactome:REACT_30020 "Phosphorylation (Ser5) of RNA pol II CTD, Rattus norvegicus" xref: Reactome:REACT_30023 "Phosphorylation (Ser5) of RNA pol II CTD, Xenopus tropicalis" xref: Reactome:REACT_30052 "Phosphorylation of BRCA1 at multiple sites by ATM, Bos taurus" xref: Reactome:REACT_30070 "Phosphorylation of L1 by CK-II, Mus musculus" xref: Reactome:REACT_30084 "PIP2 conversion to PIP3, Canis familiaris" xref: Reactome:REACT_30113 "SOS phosphorylation and dissociation (IRS, Crk), Drosophila melanogaster" xref: Reactome:REACT_30116 "Phosphorylation and activation of eIF4B by activated S6K1, Canis familiaris" xref: Reactome:REACT_30165 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Gallus gallus" xref: Reactome:REACT_302 "Phosphorylation and activation of Chk1 by ATM, Homo sapiens" xref: Reactome:REACT_30230 "Phosphorylation of the SA2 Cohesin Complex, Caenorhabditis elegans" xref: Reactome:REACT_30345 "RAF1 phosphorylates MEK1, Gallus gallus" xref: Reactome:REACT_30490 "Inactivation of Myt1 kinase, Danio rerio" xref: Reactome:REACT_30496 "Phosphorylation of the Scc1:Cohesion Complex, Xenopus tropicalis" xref: Reactome:REACT_30679 "Phosphorylation and inactivation of eEF2K by activated S6K1, Mus musculus" xref: Reactome:REACT_30700 "Phosphorylation of BRCA1 at multiple sites by ATM, Gallus gallus" xref: Reactome:REACT_30836 "Inactivation of Myt1 kinase, Bos taurus" xref: Reactome:REACT_30921 "Phosphorylation and activation of Chk1 by ATM, Xenopus tropicalis" xref: Reactome:REACT_30938 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Canis familiaris" xref: Reactome:REACT_30948 "PIP2 conversion to PIP3, Gallus gallus" xref: Reactome:REACT_30985 "Plk1-mediated phosphorylation of Nlp, Canis familiaris" xref: Reactome:REACT_30997 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Rattus norvegicus" xref: Reactome:REACT_31081 "Phosphorylation of TSC2 by PKB, Canis familiaris" xref: Reactome:REACT_31149 "Phosphorylation of the Scc1:Cohesion Complex, Danio rerio" xref: Reactome:REACT_31196 "Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB, Canis familiaris" xref: Reactome:REACT_31227 "Regulation of KIF20A (MKL2) by phosphorylation, Gallus gallus" xref: Reactome:REACT_31273 "Phosphorylation of the Scc1:Cohesion Complex, Canis familiaris" xref: Reactome:REACT_31290 "Orc1 is phosphorylated by cyclin A/CDK2, Rattus norvegicus" xref: Reactome:REACT_31293 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Danio rerio" xref: Reactome:REACT_31449 "Phosphorylation and activation of CHK2 by ATM, Danio rerio" xref: Reactome:REACT_31466 "Activation of S6K1, Bos taurus" xref: Reactome:REACT_31519 "Phosphorylation of the SA2 Cohesin Complex, Danio rerio" xref: Reactome:REACT_31536 "Phosphorylation of NBS1 by ATM, Taeniopygia guttata" xref: Reactome:REACT_31571 "Autophosphorylation of PAK-2p34 in the activation loop, Gallus gallus" xref: Reactome:REACT_31625 "Phosphorylation of L1 by ERK, Taeniopygia guttata" xref: Reactome:REACT_31639 "SOS phosphorylation and dissociation (SHC), Rattus norvegicus" xref: Reactome:REACT_31868 "Phosphorylation and activation of CHK2 by ATM, Canis familiaris" xref: Reactome:REACT_31915 "Phosphorylation of L1 by CK-II, Drosophila melanogaster" xref: Reactome:REACT_31935 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Sus scrofa" xref: Reactome:REACT_31984 "Phosphorylation (Ser5) of RNA pol II CTD, Arabidopsis thaliana" xref: Reactome:REACT_32009 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Mus musculus" xref: Reactome:REACT_32077 "Inactivation of Myt1 kinase, Dictyostelium discoideum" xref: Reactome:REACT_32079 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Danio rerio" xref: Reactome:REACT_32145 "Phosphorylation of COP1 at Ser-387 by ATM, Canis familiaris" xref: Reactome:REACT_32150 "Phosphorylation of NBS1 by ATM, Arabidopsis thaliana" xref: Reactome:REACT_32271 "Phosphorylation of cPLA2 by ERK-2, Taeniopygia guttata" xref: Reactome:REACT_32358 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Canis familiaris" xref: Reactome:REACT_32374 "Mcm2-7 is phosphorylated by DDK, Canis familiaris" xref: Reactome:REACT_32438 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Sus scrofa" xref: Reactome:REACT_32492 "Phosphorylation of BRCA1 at multiple sites by ATM, Rattus norvegicus" xref: Reactome:REACT_32565 "Phosphorylation of NBS1 by ATM, Gallus gallus" xref: Reactome:REACT_32598 "Phosphorylation and activation of eIF4B by activated S6K1, Taeniopygia guttata" xref: Reactome:REACT_32620 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Bos taurus" xref: Reactome:REACT_32845 "Phosphorylation of Cyclin D:Cdk4/6 complexes, Rattus norvegicus" xref: Reactome:REACT_32906 "Phosphorylation and inactivation of eEF2K by activated S6K1, Sus scrofa" xref: Reactome:REACT_32956 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Mus musculus" xref: Reactome:REACT_33003 "Phosphorylation of the SA2 Cohesin Complex, Dictyostelium discoideum" xref: Reactome:REACT_33009 "Phosphorylation of L1 by ERK, Danio rerio" xref: Reactome:REACT_33080 "Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB, Taeniopygia guttata" xref: Reactome:REACT_33369 "Phosphorylation of NBS1 by ATM, Rattus norvegicus" xref: Reactome:REACT_33385 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Canis familiaris" xref: Reactome:REACT_33519 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Mus musculus" xref: Reactome:REACT_33532 "Phosphorylation of complexed TSC2 by PKB, Bos taurus" xref: Reactome:REACT_33692 "Phosphorylation of BRCA1 at multiple sites by ATM, Taeniopygia guttata" xref: Reactome:REACT_33840 "Regulation of KIF23 (MKLP1) by phosphorylation, Schizosaccharomyces pombe" xref: Reactome:REACT_33928 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Sus scrofa" xref: Reactome:REACT_33979 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Rattus norvegicus" xref: Reactome:REACT_34080 "Phosphorylation of PD-1, Mus musculus" xref: Reactome:REACT_34111 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Canis familiaris" xref: Reactome:REACT_34145 "Phosphorylation of cPLA2 by ERK-2, Xenopus tropicalis" xref: Reactome:REACT_34222 "Phosphorylation of L1 by ERK, Rattus norvegicus" xref: Reactome:REACT_34285 "Activation of Cdc25C, Bos taurus" xref: Reactome:REACT_34310 "Phosphorylation and activation of Chk1 by ATM, Bos taurus" xref: Reactome:REACT_34403 "Phosphorylation (Ser5) of RNA pol II CTD, Danio rerio" xref: Reactome:REACT_34514 "Phosphorylation and inactivation of eEF2K by activated S6K1, Danio rerio" xref: Reactome:REACT_34516 "Cdc6 protein is phosphorylated by CDK, Canis familiaris" xref: Reactome:REACT_34607 "Phosphorylation of 4E-BP1 by activated mTORC1, Bos taurus" xref: Reactome:REACT_34741 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Rattus norvegicus" xref: Reactome:REACT_34788 "Phosphorylation and inactivation of eEF2K by activated S6K1, Xenopus tropicalis" xref: Reactome:REACT_34804 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Gallus gallus" xref: Reactome:REACT_384 "Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1, Homo sapiens" xref: Reactome:REACT_414 "Inactivation of Myt1 kinase, Homo sapiens" xref: Reactome:REACT_41715 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Mus musculus" xref: Reactome:REACT_43 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Homo sapiens" xref: Reactome:REACT_496 "Down Regulation of Emi1 through Phosphorylation of Emi1, Homo sapiens" xref: Reactome:REACT_54449 "Phosphorylation and activation of eIF4G by activated S6K1, Mus musculus" xref: Reactome:REACT_545 "RAF1 phosphorylates MEK1, Homo sapiens" xref: Reactome:REACT_559 "Phosphorylation and activation of Chk1 by ATM kinase, Mus musculus" xref: Reactome:REACT_58131 "PIP2 conversion to PIP3, Mus musculus" xref: Reactome:REACT_6139 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Homo sapiens" xref: Reactome:REACT_6170 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex, Homo sapiens" xref: Reactome:REACT_6178 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Homo sapiens" xref: Reactome:REACT_6234 "Phosphorylation (Ser5) of RNA pol II CTD, Homo sapiens" xref: Reactome:REACT_6297 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Homo sapiens" xref: Reactome:REACT_6311 "Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex, Homo sapiens" xref: Reactome:REACT_6314 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Homo sapiens" xref: Reactome:REACT_6316 "Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex, Human immunodeficiency virus 1" xref: Reactome:REACT_6327 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Homo sapiens" xref: Reactome:REACT_6342 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Homo sapiens" xref: Reactome:REACT_6353 "Phosphorylation of Cyclin B1 in the CRS domain, Homo sapiens" xref: Reactome:REACT_6725 "Phosphorylation of TSC2 by PKB, Homo sapiens" xref: Reactome:REACT_6778 "Phosphorylation and activation of eIF4B by activated S6K1, Homo sapiens" xref: Reactome:REACT_6859 "Free APC/C phosphorylated by Plk1, Homo sapiens" xref: Reactome:REACT_6861 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Homo sapiens" xref: Reactome:REACT_6870 "Phosphorylation and activation of eIF4G by activated S6K1, Homo sapiens" xref: Reactome:REACT_6873 "Phosphorylation of 4E-BP1 by activated mTORC1, Homo sapiens" xref: Reactome:REACT_6883 "Phosphorylation and inactivation of eEF2K by activated S6K1, Homo sapiens" xref: Reactome:REACT_6912 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Homo sapiens" xref: Reactome:REACT_6948 "Activation of S6K1, Homo sapiens" xref: Reactome:REACT_6952 "Phosphorylation of complexed TSC2 by PKB, Homo sapiens" xref: Reactome:REACT_76979 "Phosphorylation of Cyclin D:Cdk4/6 complexes, Danio rerio" xref: Reactome:REACT_77040 "Phosphorylation of COP1 at Ser-387 by ATM, Oryza sativa" xref: Reactome:REACT_77074 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Mus musculus" xref: Reactome:REACT_77179 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Bos taurus" xref: Reactome:REACT_77231 "Phosphorylation of DLC2 by MAPK-8, Gallus gallus" xref: Reactome:REACT_77234 "Plk1-mediated phosphorylation of Nlp, Gallus gallus" xref: Reactome:REACT_773 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Homo sapiens" xref: Reactome:REACT_77326 "RAF1 phosphorylates MEK2, Taeniopygia guttata" xref: Reactome:REACT_77362 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Rattus norvegicus" xref: Reactome:REACT_77365 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Xenopus tropicalis" xref: Reactome:REACT_77397 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Mus musculus" xref: Reactome:REACT_77407 "Regulation of NUDC by phosphorylation, Bos taurus" xref: Reactome:REACT_77443 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Danio rerio" xref: Reactome:REACT_77450 "Phosphorylation of L1 by CK-II, Sus scrofa" xref: Reactome:REACT_77535 "Phosphorylation of Cyclin D:Cdk4/6 complexes, Mus musculus" xref: Reactome:REACT_77550 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Drosophila melanogaster" xref: Reactome:REACT_77566 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Gallus gallus" xref: Reactome:REACT_77606 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Canis familiaris" xref: Reactome:REACT_77615 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Gallus gallus" xref: Reactome:REACT_77654 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Drosophila melanogaster" xref: Reactome:REACT_77660 "Regulation of KIF23 (MKLP1) by phosphorylation, Caenorhabditis elegans" xref: Reactome:REACT_77733 "Phosphorylation of PDE3B, Danio rerio" xref: Reactome:REACT_77834 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Rattus norvegicus" xref: Reactome:REACT_77857 "Phosphorylation (Ser5) of RNA pol II CTD, Drosophila melanogaster" xref: Reactome:REACT_77897 "Phosphorylation of Wee1 kinase by Chk1, Taeniopygia guttata" xref: Reactome:REACT_77911 "Mcm2-7 is phosphorylated by DDK, Taeniopygia guttata" xref: Reactome:REACT_77928 "Autophosphorylation of PAK-2p34 in the activation loop, Sus scrofa" xref: Reactome:REACT_77949 "Phosphorylation of Wee1 kinase by Chk1, Drosophila melanogaster" xref: Reactome:REACT_77977 "Phosphorylation of Cyclin B1 in the CRS domain, Bos taurus" xref: Reactome:REACT_78014 "Plk1-mediated phosphorylation of Nlp, Taeniopygia guttata" xref: Reactome:REACT_78035 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Taeniopygia guttata" xref: Reactome:REACT_78087 "Phosphorylation of TSC2 by PKB, Xenopus tropicalis" xref: Reactome:REACT_78121 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Gallus gallus" xref: Reactome:REACT_78226 "Regulation of NUDC by phosphorylation, Xenopus tropicalis" xref: Reactome:REACT_78281 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Rattus norvegicus" xref: Reactome:REACT_78427 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Danio rerio" xref: Reactome:REACT_78450 "Phosphorylation and activation of eIF4B by activated S6K1, Drosophila melanogaster" xref: Reactome:REACT_78451 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Taeniopygia guttata" xref: Reactome:REACT_78503 "Phosphorylation of histone H2AX at Serine-139 by ATM at the site of DSB, Bos taurus" xref: Reactome:REACT_78533 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Danio rerio" xref: Reactome:REACT_78539 "Down Regulation of Emi1 through Phosphorylation of Emi1, Xenopus tropicalis" xref: Reactome:REACT_78556 "Free APC/C phosphorylated by Plk1, Drosophila melanogaster" xref: Reactome:REACT_78625 "Phosphorylation and inactivation of eEF2K by activated S6K1, Caenorhabditis elegans" xref: Reactome:REACT_78651 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Rattus norvegicus" xref: Reactome:REACT_78696 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Xenopus tropicalis" xref: Reactome:REACT_78748 "Cdc6 protein is phosphorylated by CDK, Drosophila melanogaster" xref: Reactome:REACT_78901 "Phosphorylation (Ser5) of RNA pol II CTD, Mus musculus" xref: Reactome:REACT_79012 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Schizosaccharomyces pombe" xref: Reactome:REACT_79039 "Autophosphorylation of PAK-2p34 in the activation loop, Caenorhabditis elegans" xref: Reactome:REACT_79087 "Phosphorylation of Wee1 kinase by Chk1, Oryza sativa" xref: Reactome:REACT_79125 "SOS phosphorylation and dissociation (IRS), Bos taurus" xref: Reactome:REACT_79182 "Phosphorylation of Cyclin B1 in the CRS domain, Canis familiaris" xref: Reactome:REACT_79208 "Mcm2-7 is phosphorylated by DDK, Bos taurus" xref: Reactome:REACT_79220 "Phosphorylation of 4E-BP1 by activated mTORC1, Canis familiaris" xref: Reactome:REACT_79255 "Phosphorylation of p53 at ser-15 by ATM kinase, Danio rerio" xref: Reactome:REACT_79372 "Cdc6 protein is phosphorylated by CDK, Danio rerio" xref: Reactome:REACT_79573 "Phosphorylation of p53 at ser-15 by ATM kinase, Mus musculus" xref: Reactome:REACT_79686 "Phosphorylation of the Scc1:Cohesion Complex, Drosophila melanogaster" xref: Reactome:REACT_79694 "Autophosphorylation of PAK-2p34 in the activation loop, Xenopus tropicalis" xref: Reactome:REACT_79700 "Activation of S6K1, Taeniopygia guttata" xref: Reactome:REACT_79709 "Orc1 is phosphorylated by cyclin A/CDK2, Mus musculus" xref: Reactome:REACT_79720 "Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1, Danio rerio" xref: Reactome:REACT_80110 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Drosophila melanogaster" xref: Reactome:REACT_80144 "Phosphorylation of complexed TSC2 by PKB, Sus scrofa" xref: Reactome:REACT_80185 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Mus musculus" xref: Reactome:REACT_80213 "Activation of S6K1, Canis familiaris" xref: Reactome:REACT_80218 "Phosphorylation of the Scc1:Cohesion Complex, Dictyostelium discoideum" xref: Reactome:REACT_80239 "Regulation of KIF20A (MKL2) by phosphorylation, Dictyostelium discoideum" xref: Reactome:REACT_80255 "Mcm2-7 is phosphorylated by DDK, Mus musculus" xref: Reactome:REACT_80591 "Regulation of KIF20A (MKL2) by phosphorylation, Drosophila melanogaster" xref: Reactome:REACT_80606 "Phosphorylation of NBS1 by ATM, Oryza sativa" xref: Reactome:REACT_80617 "Inactivation of Wee1 kinase, Xenopus tropicalis" xref: Reactome:REACT_80632 "Phosphorylation of L1 by ERK, Schizosaccharomyces pombe" xref: Reactome:REACT_80665 "Down Regulation of Emi1 through Phosphorylation of Emi1, Taeniopygia guttata" xref: Reactome:REACT_80684 "Phosphorylation of COP1 at Ser-387 by ATM, Arabidopsis thaliana" xref: Reactome:REACT_80689 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Oryza sativa" xref: Reactome:REACT_80699 "PIP2 conversion to PIP3, Danio rerio" xref: Reactome:REACT_80700 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Sus scrofa" xref: Reactome:REACT_80714 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Rattus norvegicus" xref: Reactome:REACT_80804 "Phosphorylation of PDE3B, Bos taurus" xref: Reactome:REACT_80853 "Phosphorylation (Ser5) of RNA pol II CTD, Dictyostelium discoideum" xref: Reactome:REACT_80860 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Rattus norvegicus" xref: Reactome:REACT_80909 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Drosophila melanogaster" xref: Reactome:REACT_81027 "PIP2 conversion to PIP3, Sus scrofa" xref: Reactome:REACT_81148 "Phosphorylation and activation of CHK2 by ATM, Taeniopygia guttata" xref: Reactome:REACT_81218 "Phosphorylation and activation of CHK2 by ATM, Rattus norvegicus" xref: Reactome:REACT_81439 "Phosphorylation of APC component of the destruction complex, Xenopus tropicalis" xref: Reactome:REACT_81458 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Bos taurus" xref: Reactome:REACT_81490 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Xenopus tropicalis" xref: Reactome:REACT_81590 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Bos taurus" xref: Reactome:REACT_81616 "Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1, Canis familiaris" xref: Reactome:REACT_81647 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Rattus norvegicus" xref: Reactome:REACT_81652 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Rattus norvegicus" xref: Reactome:REACT_81693 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Drosophila melanogaster" xref: Reactome:REACT_81715 "Orc1 is phosphorylated by cyclin A/CDK2, Drosophila melanogaster" xref: Reactome:REACT_81727 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Danio rerio" xref: Reactome:REACT_81864 "Phosphorylation of Cx43 by c-src, Bos taurus" xref: Reactome:REACT_81941 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Bos taurus" xref: Reactome:REACT_82037 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Mus musculus" xref: Reactome:REACT_82115 "Phosphorylation and activation of Chk1 by ATM, Saccharomyces cerevisiae" xref: Reactome:REACT_82125 "Phosphorylation of complexed TSC2 by PKB, Danio rerio" xref: Reactome:REACT_82128 "PIP2 conversion to PIP3, Taeniopygia guttata" xref: Reactome:REACT_82261 "Phosphorylation of DLC2 by MAPK-8, Xenopus tropicalis" xref: Reactome:REACT_82270 "Autophosphorylation of PAK-2p34 in the activation loop, Rattus norvegicus" xref: Reactome:REACT_82303 "Phosphorylation of Cyclin D:Cdk4/6 complexes, Xenopus tropicalis" xref: Reactome:REACT_82310 "Phosphorylation and activation of Chk1 by ATM, Gallus gallus" xref: Reactome:REACT_82361 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Canis familiaris" xref: Reactome:REACT_82456 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Bos taurus" xref: Reactome:REACT_82473 "Phosphorylation of the SA2 Cohesin Complex, Canis familiaris" xref: Reactome:REACT_82616 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Mus musculus" xref: Reactome:REACT_82678 "Phosphorylation of complexed TSC2 by PKB, Rattus norvegicus" xref: Reactome:REACT_82728 "Plk1-mediated phosphorylation of Nlp, Mus musculus" xref: Reactome:REACT_82751 "Down Regulation of Emi1 through Phosphorylation of Emi1, Rattus norvegicus" xref: Reactome:REACT_82824 "Inactivation of Wee1 kinase, Rattus norvegicus" xref: Reactome:REACT_82901 "Phosphorylation of DLC2 by MAPK-8, Canis familiaris" xref: Reactome:REACT_82927 "PIP2 conversion to PIP3, Rattus norvegicus" xref: Reactome:REACT_83006 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Caenorhabditis elegans" xref: Reactome:REACT_83089 "Inactivation of Myt1 kinase, Saccharomyces cerevisiae" xref: Reactome:REACT_83110 "Phosphorylation (Ser5) of RNA pol II CTD, Schizosaccharomyces pombe" xref: Reactome:REACT_83178 "Phosphorylation and activation of Chk1 by ATM, Oryza sativa" xref: Reactome:REACT_83187 "Phosphorylation of the SA2 Cohesin Complex, Mus musculus" xref: Reactome:REACT_83239 "Phosphorylation and activation of eIF4G by activated S6K1, Gallus gallus" xref: Reactome:REACT_83279 "Phosphorylation of NBS1 by ATM, Canis familiaris" xref: Reactome:REACT_83297 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Danio rerio" xref: Reactome:REACT_83436 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Arabidopsis thaliana" xref: Reactome:REACT_83476 "Phosphorylation and activation of CHK2 by ATM, Mus musculus" xref: Reactome:REACT_83529 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Drosophila melanogaster" xref: Reactome:REACT_83533 "Phosphorylation and activation of Chk1 by ATM, Rattus norvegicus" xref: Reactome:REACT_83579 "Phosphorylation of Wee1 kinase by Chk1, Gallus gallus" xref: Reactome:REACT_83582 "Plk1-mediated phosphorylation of Nlp, Danio rerio" xref: Reactome:REACT_83671 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Taeniopygia guttata" xref: Reactome:REACT_83696 "Free APC/C phosphorylated by Plk1, Bos taurus" xref: Reactome:REACT_83709 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Mus musculus" xref: Reactome:REACT_83727 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Gallus gallus" xref: Reactome:REACT_83899 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Sus scrofa" xref: Reactome:REACT_83979 "Phosphorylation of COP1 at Ser-387 by ATM, Mus musculus" xref: Reactome:REACT_84080 "Phosphorylation of the SA2 Cohesin Complex, Xenopus tropicalis" xref: Reactome:REACT_84082 "Phosphorylation of Wee1 kinase by Chk1, Rattus norvegicus" xref: Reactome:REACT_84208 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Mus musculus" xref: Reactome:REACT_84273 "Phosphorylation of L1 by ERK, Sus scrofa" xref: Reactome:REACT_84348 "Phosphorylation of COP1 at Ser-387 by ATM, Taeniopygia guttata" xref: Reactome:REACT_84405 "Phosphorylation of p53 at ser-15 by ATM kinase, Rattus norvegicus" xref: Reactome:REACT_845 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Homo sapiens" xref: Reactome:REACT_84560 "Cdc6 protein is phosphorylated by CDK, Saccharomyces cerevisiae" xref: Reactome:REACT_84656 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Bos taurus" xref: Reactome:REACT_84932 "Phosphorylation of Wee1 kinase by Chk1, Sus scrofa" xref: Reactome:REACT_85009 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Taeniopygia guttata" xref: Reactome:REACT_85017 "Activation of S6K1, Dictyostelium discoideum" xref: Reactome:REACT_85044 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Canis familiaris" xref: Reactome:REACT_85066 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Taeniopygia guttata" xref: Reactome:REACT_85256 "Phosphorylation of Cdc25C at Ser216, Mus musculus" xref: Reactome:REACT_85328 "Regulation of KIF20A (MKL2) by phosphorylation, Mus musculus" xref: Reactome:REACT_85379 "Phosphorylation of Cx43 by c-src, Sus scrofa" xref: Reactome:REACT_85449 "Phosphorylation and activation of eIF4G by activated S6K1, Bos taurus" xref: Reactome:REACT_85586 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Gallus gallus" xref: Reactome:REACT_85699 "Phosphorylation of Cyclin B1 in the CRS domain, Rattus norvegicus" xref: Reactome:REACT_85720 "Phosphorylation of L1 by ERK, Canis familiaris" xref: Reactome:REACT_85745 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Xenopus tropicalis" xref: Reactome:REACT_85751 "Phosphorylation of BRCA1 at multiple sites by ATM, Canis familiaris" xref: Reactome:REACT_85812 "Phosphorylation and activation of Chk1 by ATM, Drosophila melanogaster" xref: Reactome:REACT_85836 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Gallus gallus" xref: Reactome:REACT_85871 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Mus musculus" xref: Reactome:REACT_86014 "Phosphorylation of the SA2 Cohesin Complex, Bos taurus" xref: Reactome:REACT_86033 "Phosphorylation and activation of CHK2 by ATM, Schizosaccharomyces pombe" xref: Reactome:REACT_86061 "Phosphorylation of Cyclin E1:Cdk2 complexes by Myt1, Bos taurus" xref: Reactome:REACT_86092 "Phosphorylation of COP1 at Ser-387 by ATM, Bos taurus" xref: Reactome:REACT_86211 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Saccharomyces cerevisiae" xref: Reactome:REACT_86252 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Drosophila melanogaster" xref: Reactome:REACT_86261 "Regulation of NUDC by phosphorylation, Dictyostelium discoideum" xref: Reactome:REACT_86277 "Phosphorylation of TSC2 by PKB, Bos taurus" xref: Reactome:REACT_86365 "Phosphorylation and activation of eIF4G by activated S6K1, Rattus norvegicus" xref: Reactome:REACT_86372 "Akt1 phosphorylates BAD protein, Mus musculus" xref: Reactome:REACT_86415 "Phosphorylation of Cx43 by c-src, Xenopus tropicalis" xref: Reactome:REACT_86422 "Phosphorylation of PD-1, Rattus norvegicus" xref: Reactome:REACT_86533 "Cdc6 protein is phosphorylated by CDK, Sus scrofa" xref: Reactome:REACT_86736 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Rattus norvegicus" xref: Reactome:REACT_86800 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Danio rerio" xref: Reactome:REACT_86867 "Phosphorylation of p53 at ser-15 by ATM kinase, Bos taurus" xref: Reactome:REACT_86952 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Sus scrofa" xref: Reactome:REACT_86967 "Phosphorylation (Ser5) of RNA pol II CTD, Gallus gallus" xref: Reactome:REACT_87010 "Regulation of NUDC by phosphorylation, Danio rerio" xref: Reactome:REACT_87121 "Phosphorylation of cPLA2 by ERK-2, Bos taurus" xref: Reactome:REACT_87149 "Phosphorylation of L1 by CK-II, Danio rerio" xref: Reactome:REACT_87212 "Phosphorylation of Cx43 by c-src, Mus musculus" xref: Reactome:REACT_87222 "Cdc6 protein is phosphorylated by CDK, Schizosaccharomyces pombe" xref: Reactome:REACT_87298 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Sus scrofa" xref: Reactome:REACT_87329 "Regulation of KIF23 (MKLP1) by phosphorylation, Mus musculus" xref: Reactome:REACT_87391 "Phosphorylation of Cx43 by c-src, Rattus norvegicus" xref: Reactome:REACT_87424 "SOS phosphorylation and dissociation (SHC), Danio rerio" xref: Reactome:REACT_87437 "Phosphorylation of AKT2 by PDK1, Caenorhabditis elegans" xref: Reactome:REACT_87485 "Activation of S6K1, Xenopus tropicalis" xref: Reactome:REACT_87497 "Akt1 phosphorylates BAD protein, Bos taurus" xref: Reactome:REACT_87503 "Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1, Xenopus tropicalis" xref: Reactome:REACT_87523 "Phosphorylation of Cyclin B1 in the CRS domain, Mus musculus" xref: Reactome:REACT_87534 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Gallus gallus" xref: Reactome:REACT_87593 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Gallus gallus" xref: Reactome:REACT_87650 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Xenopus tropicalis" xref: Reactome:REACT_87679 "Phosphorylation of PDE3B, Xenopus tropicalis" xref: Reactome:REACT_87753 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Bos taurus" xref: Reactome:REACT_87880 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes, Danio rerio" xref: Reactome:REACT_87967 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Xenopus tropicalis" xref: Reactome:REACT_88025 "Activation of S6K1, Mus musculus" xref: Reactome:REACT_88055 "Phosphorylation of NBS1 by ATM, Sus scrofa" xref: Reactome:REACT_88091 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Xenopus tropicalis" xref: Reactome:REACT_88220 "Regulation of KIF23 (MKLP1) by phosphorylation, Rattus norvegicus" xref: Reactome:REACT_88298 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Taeniopygia guttata" xref: Reactome:REACT_88326 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Canis familiaris" xref: Reactome:REACT_88374 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Xenopus tropicalis" xref: Reactome:REACT_88421 "Phosphorylation and inactivation of eEF2K by activated S6K1, Rattus norvegicus" xref: Reactome:REACT_88430 "Orc1 is phosphorylated by cyclin A/CDK2, Bos taurus" xref: Reactome:REACT_88440 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Caenorhabditis elegans" xref: Reactome:REACT_88458 "Phosphorylation of cPLA2 by ERK-2, Danio rerio" xref: Reactome:REACT_88486 "Inactivation of Wee1 kinase, Taeniopygia guttata" xref: Reactome:REACT_88516 "Cdc6 protein is phosphorylated by CDK, Rattus norvegicus" xref: Reactome:REACT_88548 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Taeniopygia guttata" xref: Reactome:REACT_88564 "Plk1-mediated phosphorylation of Nlp, Xenopus tropicalis" xref: Reactome:REACT_88590 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Rattus norvegicus" xref: Reactome:REACT_88665 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Danio rerio" xref: Reactome:REACT_88668 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Drosophila melanogaster" xref: Reactome:REACT_88766 "Phosphorylation (Ser5) of RNA pol II CTD, Oryza sativa" xref: Reactome:REACT_88871 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex, Rattus norvegicus" xref: Reactome:REACT_88928 "Autophosphorylation of PAK-2p34 in the activation loop, Drosophila melanogaster" xref: Reactome:REACT_88987 "Free APC/C phosphorylated by Plk1, Canis familiaris" xref: Reactome:REACT_89001 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Gallus gallus" xref: Reactome:REACT_89026 "Phosphorylation of PD-1, Gallus gallus" xref: Reactome:REACT_89122 "Activation of Cdc25C, Canis familiaris" xref: Reactome:REACT_89366 "Phosphorylation of APC component of the destruction complex, Canis familiaris" xref: Reactome:REACT_89427 "Phosphorylation of AKT2 by PDK1, Bos taurus" xref: Reactome:REACT_89464 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Taeniopygia guttata" xref: Reactome:REACT_89547 "Phosphorylation of NBS1 by ATM, Xenopus tropicalis" xref: Reactome:REACT_89579 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Xenopus tropicalis" xref: Reactome:REACT_89769 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Taeniopygia guttata" xref: Reactome:REACT_89794 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Mus musculus" xref: Reactome:REACT_89879 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Mus musculus" xref: Reactome:REACT_89988 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Schizosaccharomyces pombe" xref: Reactome:REACT_9007 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Homo sapiens" xref: Reactome:REACT_90132 "Phosphorylation of AKT2 by PDK1, Sus scrofa" xref: Reactome:REACT_90167 "Phosphorylation of Wee1 kinase by Chk1, Bos taurus" xref: Reactome:REACT_90220 "Wee1- mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes, Rattus norvegicus" xref: Reactome:REACT_90227 "Phosphorylation of AKT2 by PDK1, Mus musculus" xref: Reactome:REACT_90290 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Taeniopygia guttata" xref: Reactome:REACT_90364 "Regulation of NUDC by phosphorylation, Canis familiaris" xref: Reactome:REACT_90426 "Phosphorylation of Wee1 kinase by Chk1, Mus musculus" xref: Reactome:REACT_90449 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Canis familiaris" xref: Reactome:REACT_90562 "Regulation of NUDC by phosphorylation, Drosophila melanogaster" xref: Reactome:REACT_9057 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Homo sapiens" xref: Reactome:REACT_9067 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Homo sapiens" xref: Reactome:REACT_90675 "Phosphorylation (Ser5) of RNA pol II CTD, Caenorhabditis elegans" xref: Reactome:REACT_907 "Mcm2-7 is phosphorylated by DDK, Homo sapiens" xref: Reactome:REACT_9070 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Homo sapiens" xref: Reactome:REACT_908 "Phosphorylation of AKT2 by PDK1, Homo sapiens" xref: Reactome:REACT_90917 "Phosphorylation of Wee1 kinase by Chk1, Canis familiaris" xref: Reactome:REACT_91050 "SOS phosphorylation and dissociation (IRS, Crk), Mus musculus" xref: Reactome:REACT_91062 "Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1, Bos taurus" xref: Reactome:REACT_91085 "Inactivation of Wee1 kinase, Danio rerio" xref: Reactome:REACT_91156 "Phosphorylation and activation of CHK2 by ATM, Gallus gallus" xref: Reactome:REACT_91157 "Phosphorylation (Ser5) of RNA pol II CTD, Saccharomyces cerevisiae" xref: Reactome:REACT_91196 "Phosphorylation of 4E-BP1 by activated mTORC1, Mus musculus" xref: Reactome:REACT_91197 "Phosphorylation and activation of eIF4B by activated S6K1, Mus musculus" xref: Reactome:REACT_91240 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Xenopus tropicalis" xref: Reactome:REACT_91263 "Down Regulation of Emi1 through Phosphorylation of Emi1, Gallus gallus" xref: Reactome:REACT_91382 "SOS phosphorylation and dissociation (IRS), Danio rerio" xref: Reactome:REACT_91470 "Regulation of KIF20A (MKL2) by phosphorylation, Canis familiaris" xref: Reactome:REACT_91501 "PIP2 conversion to PIP3, Bos taurus" xref: Reactome:REACT_91541 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Rattus norvegicus" xref: Reactome:REACT_91574 "Phosphorylation of DLC2 by MAPK-8, Rattus norvegicus" xref: Reactome:REACT_91643 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Drosophila melanogaster" xref: Reactome:REACT_91684 "Phosphorylation of the SA2 Cohesin Complex, Drosophila melanogaster" xref: Reactome:REACT_91760 "Regulation of KIF23 (MKLP1) by phosphorylation, Danio rerio" xref: Reactome:REACT_91937 "Phosphorylation of APC component of the destruction complex, Bos taurus" xref: Reactome:REACT_92033 "Inactivation of Myt1 kinase, Caenorhabditis elegans" xref: Reactome:REACT_92108 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Rattus norvegicus" xref: Reactome:REACT_92126 "Activation of S6K1, Oryza sativa" xref: Reactome:REACT_92148 "Autophosphorylation of PAK-2p34 in the activation loop, Danio rerio" xref: Reactome:REACT_92219 "Phosphorylation of PDE3B, Caenorhabditis elegans" xref: Reactome:REACT_92247 "Phosphorylation of the Emi1 DSGxxS degron by Plk1, Canis familiaris" xref: Reactome:REACT_92407 "Regulation of KIF23 (MKLP1) by phosphorylation, Canis familiaris" xref: Reactome:REACT_92735 "Autophosphorylation of PAK-2p34 in the activation loop, Taeniopygia guttata" xref: Reactome:REACT_92736 "Phosphorylation of L1 by ERK, Gallus gallus" xref: Reactome:REACT_92804 "Phosphorylation of Wee1 kinase by Chk1, Danio rerio" xref: Reactome:REACT_92852 "SOS phosphorylation and dissociation (SHC), Canis familiaris" xref: Reactome:REACT_92889 "Phosphorylation of TSC2 by PKB, Sus scrofa" xref: Reactome:REACT_92915 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Danio rerio" xref: Reactome:REACT_92929 "RAF1 phosphorylates MEK1, Danio rerio" xref: Reactome:REACT_92951 "Phosphorylation and activation of Chk1 by ATM, Canis familiaris" xref: Reactome:REACT_93018 "RAF1 phosphorylates MEK1, Bos taurus" xref: Reactome:REACT_93105 "Phosphorylation of cPLA2 by ERK-2, Rattus norvegicus" xref: Reactome:REACT_93124 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes, Mus musculus" xref: Reactome:REACT_93149 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Dictyostelium discoideum" xref: Reactome:REACT_93166 "Phosphorylation and activation of Chk1 by ATM, Taeniopygia guttata" xref: Reactome:REACT_93219 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Xenopus tropicalis" xref: Reactome:REACT_93221 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Xenopus tropicalis" xref: Reactome:REACT_93346 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Mus musculus" xref: Reactome:REACT_93366 "Phosphorylation of cPLA2 by ERK-2, Canis familiaris" xref: Reactome:REACT_93414 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Drosophila melanogaster" xref: Reactome:REACT_93440 "Regulation of KIF20A (MKL2) by phosphorylation, Taeniopygia guttata" xref: Reactome:REACT_93441 "Regulation of KIF23 (MKLP1) by phosphorylation, Gallus gallus" xref: Reactome:REACT_93613 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Rattus norvegicus" xref: Reactome:REACT_93615 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Bos taurus" xref: Reactome:REACT_937 "Phosphorylation of BRCA1 at multiple sites by ATM, Homo sapiens" xref: Reactome:REACT_93706 "RAF1 phosphorylates MEK1, Canis familiaris" xref: Reactome:REACT_93746 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Mus musculus" xref: Reactome:REACT_93878 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Gallus gallus" xref: Reactome:REACT_94017 "SOS phosphorylation and dissociation (IRS, Crk), Bos taurus" xref: Reactome:REACT_94113 "Phosphorylation of Cx43 by c-src, Canis familiaris" xref: Reactome:REACT_94151 "Phosphorylation of Wee1 kinase by Chk1, Xenopus tropicalis" xref: Reactome:REACT_94248 "SOS phosphorylation and dissociation (SHC), Bos taurus" xref: Reactome:REACT_94258 "Phosphorylation of p53 at ser-15 by ATM kinase, Sus scrofa" xref: Reactome:REACT_94298 "Phosphorylation of Cyclin B1 in the CRS domain, Danio rerio" xref: Reactome:REACT_94397 "Orc1 is phosphorylated by cyclin A/CDK2, Danio rerio" xref: Reactome:REACT_94428 "Phosphorylation of PD-1, Bos taurus" xref: Reactome:REACT_94452 "Phosphorylation of MDC1/NFBD1 by ATM (within 2 c-term BRCT domains), Bos taurus" xref: Reactome:REACT_94464 "Phosphorylation and activation of eIF4B by activated S6K1, Danio rerio" xref: Reactome:REACT_94562 "Phosphorylation of the Scc1:Cohesion Complex, Caenorhabditis elegans" xref: Reactome:REACT_94615 "SOS phosphorylation and dissociation (IRS, Crk), Rattus norvegicus" xref: Reactome:REACT_94784 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta, Rattus norvegicus" xref: Reactome:REACT_94817 "Phosphorylation of the SA2 Cohesin Complex, Rattus norvegicus" xref: Reactome:REACT_94947 "Autophosphorylation of PAK-2p34 in the activation loop, Canis familiaris" xref: Reactome:REACT_95052 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Oryza sativa" xref: Reactome:REACT_95087 "Phosphorylation of the Scc1:Cohesion Complex, Bos taurus" xref: Reactome:REACT_95088 "Inactivation of Wee1 kinase, Mus musculus" xref: Reactome:REACT_95089 "Phosphorylation of Cyclin E:Cdk2 complexes by Wee-1, Bos taurus" xref: Reactome:REACT_95155 "Regulation of NUDC by phosphorylation, Taeniopygia guttata" xref: Reactome:REACT_95163 "CAK-mediated phosphorylation of Cyclin A:Cdk2, Mus musculus" xref: Reactome:REACT_95437 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Drosophila melanogaster" xref: Reactome:REACT_95461 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2, Bos taurus" xref: Reactome:REACT_95504 "Phosphorylation of Cdc25C at Ser216, Xenopus tropicalis" xref: Reactome:REACT_95769 "PIP2 conversion to PIP3, Xenopus tropicalis" xref: Reactome:REACT_96 "Phosphorylation of Cyclin D:Cdk4/6 complexes, Homo sapiens" xref: Reactome:REACT_96039 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Canis familiaris" xref: Reactome:REACT_96088 "Phosphorylation of PDE3B, Sus scrofa" xref: Reactome:REACT_96097 "SOS phosphorylation and dissociation (IRS), Rattus norvegicus" xref: Reactome:REACT_96102 "Phosphorylation of Cx43 by c-src, Gallus gallus" xref: Reactome:REACT_96129 "Phosphorylation and activation of eIF4G by activated S6K1, Taeniopygia guttata" xref: Reactome:REACT_96200 "Regulation of NUDC by phosphorylation, Gallus gallus" xref: Reactome:REACT_96208 "Phosphorylation of COP1 at Ser-387 by ATM, Sus scrofa" xref: Reactome:REACT_96218 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes, Drosophila melanogaster" xref: Reactome:REACT_96356 "Free APC/C phosphorylated by Plk1, Rattus norvegicus" xref: Reactome:REACT_96461 "Phosphorylation of L1 by CK-II, Bos taurus" xref: Reactome:REACT_96468 "Autophosphorylation of PAK-2p34 in the activation loop, Mus musculus" xref: Reactome:REACT_96483 "Phosphorylation of COP1 at Ser-387 by ATM, Gallus gallus" xref: Reactome:REACT_96500 "RAF1 phosphorylates MEK2, Gallus gallus" xref: Reactome:REACT_96524 "Activation of Cdc25C, Xenopus tropicalis" xref: Reactome:REACT_96656 "Plk1-mediated phosphorylation of Nlp, Rattus norvegicus" xref: Reactome:REACT_96666 "Phosphorylation and activation of CHK2 by ATM, Saccharomyces cerevisiae" xref: Reactome:REACT_96758 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Canis familiaris" xref: Reactome:REACT_96793 "Activation of S6K1, Danio rerio" xref: Reactome:REACT_96797 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Rattus norvegicus" xref: Reactome:REACT_96877 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Sus scrofa" xref: Reactome:REACT_96899 "Phosphorylation of TSC2 by PKB, Rattus norvegicus" xref: Reactome:REACT_96968 "Cdc6 protein is phosphorylated by CDK, Mus musculus" xref: Reactome:REACT_97193 "Phosphorylation and activation of eIF4G by activated S6K1, Canis familiaris" xref: Reactome:REACT_97218 "Orc1 is phosphorylated by cyclin A/CDK2, Xenopus tropicalis" xref: Reactome:REACT_97282 "Activation of S6K1, Sus scrofa" xref: Reactome:REACT_97299 "Phosphorylation of Cyclin E2:Cdk2 complexes by Myt1, Mus musculus" xref: Reactome:REACT_97458 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Dictyostelium discoideum" xref: Reactome:REACT_97577 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Bos taurus" xref: Reactome:REACT_97661 "Mcm2-7 is phosphorylated by DDK, Gallus gallus" xref: Reactome:REACT_97667 "Phosphorylation of complexed TSC2 by PKB, Canis familiaris" xref: Reactome:REACT_97748 "Phosphorylation of cPLA2 by ERK-2, Mus musculus" xref: Reactome:REACT_97759 "Phosphorylation of Cx43 by c-src, Danio rerio" xref: Reactome:REACT_97847 "Phosphorylation of Cdc25A at Ser-123 by Chk2, Mus musculus" xref: Reactome:REACT_97905 "Phosphorylation of BRCA1 at multiple sites by ATM, Xenopus tropicalis" xref: Reactome:REACT_98024 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Mus musculus" xref: Reactome:REACT_98050 "Phosphorylation of Cdc25C at Ser216, Canis familiaris" xref: Reactome:REACT_98066 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Saccharomyces cerevisiae" xref: Reactome:REACT_98109 "Regulation of NUDC by phosphorylation, Mus musculus" xref: Reactome:REACT_98176 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Bos taurus" xref: Reactome:REACT_98213 "Phosphorylation of Cdc25A at Ser-123 in response to DNA damage, Xenopus tropicalis" xref: Reactome:REACT_98253 "RAF1 phosphorylates MEK2, Bos taurus" xref: Reactome:REACT_98296 "Phosphorylation of Cyclin B1 in the CRS domain, Drosophila melanogaster" xref: Reactome:REACT_98373 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2, Drosophila melanogaster" xref: Reactome:REACT_98378 "Phosphorylation of COP1 at Ser-387 by ATM, Danio rerio" xref: Reactome:REACT_98395 "Phosphorylation and activation of Chk1 by ATM, Arabidopsis thaliana" xref: Reactome:REACT_98434 "Phosphorylation and inactivation of eEF2K by activated S6K1, Taeniopygia guttata" xref: Reactome:REACT_98436 "Phosphorylation of 4E-BP1 by activated mTORC1, Gallus gallus" xref: Reactome:REACT_98443 "Inactivation of Wee1 kinase, Gallus gallus" xref: Reactome:REACT_98493 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197, Drosophila melanogaster" xref: Reactome:REACT_98558 "Autophosphorylation of PAK-2p34 in the activation loop, Saccharomyces cerevisiae" xref: Reactome:REACT_98560 "Phosphorylation and activation of CHK2 by ATM, Xenopus tropicalis" xref: Reactome:REACT_98663 "Regulation of KIF23 (MKLP1) by phosphorylation, Bos taurus" xref: Reactome:REACT_98708 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Drosophila melanogaster" xref: Reactome:REACT_98731 "Phosphorylation of Cdc25A at Ser-123 by Chk1, Danio rerio" xref: Reactome:REACT_98738 "Phosphorylation of TSC2 by PKB, Danio rerio" xref: Reactome:REACT_98741 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Bos taurus" xref: Reactome:REACT_98779 "Phosphorylation of Cx43 by c-src, Taeniopygia guttata" xref: Reactome:REACT_988 "Phosphorylation of MDM2 at serine-395 by ATM kinase, Homo sapiens" xref: Reactome:REACT_98847 "Phosphorylation of complexed TSC2 by PKB, Mus musculus" xref: Reactome:REACT_98908 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Rattus norvegicus" xref: Reactome:REACT_98913 "Phosphorylation of PD-1, Canis familiaris" xref: Reactome:REACT_98971 "Phosphorylation of AKT2 by PDK1, Rattus norvegicus" xref: Reactome:REACT_98996 "Free APC/C phosphorylated by Plk1, Danio rerio" xref: Reactome:REACT_99025 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Taeniopygia guttata" xref: Reactome:REACT_99053 "CAK-mediated phosphorylation of Cyclin E:Cdk2, Sus scrofa" xref: Reactome:REACT_99141 "Phosphorylation of NBS1 by ATM, Bos taurus" xref: Reactome:REACT_99158 "Inactivation of Wee1 kinase, Drosophila melanogaster" xref: Reactome:REACT_99207 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Taeniopygia guttata" xref: Reactome:REACT_99231 "Phosphorylation of AKT2 by PDK1, Danio rerio" xref: Reactome:REACT_99266 "Activation of the Anaphase Promoting Complex (APC) by PLK1, Caenorhabditis elegans" xref: Reactome:REACT_99302 "Phosphorylation of Cyclin D:Cdk4/6 complexes, Sus scrofa" xref: Reactome:REACT_99311 "RAF1 phosphorylates MEK1, Mus musculus" xref: Reactome:REACT_9955 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Homo sapiens" xref: Reactome:REACT_99556 "Phosphorylation of Ribosomal protein S6 by activated S6K1, Mus musculus" xref: Reactome:REACT_99560 "RAF1 phosphorylates MEK2, Canis familiaris" xref: Reactome:REACT_9959 "Phosphoryation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3, Homo sapiens" xref: Reactome:REACT_99595 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15, Bos taurus" xref: Reactome:REACT_99713 "Phosphorylation of DLC2 by MAPK-8, Taeniopygia guttata" xref: Reactome:REACT_9978 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Homo sapiens" xref: Reactome:REACT_99785 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3, Canis familiaris" xref: Reactome:REACT_9983 "Phosphorylation of APC component of the destruction complex, Homo sapiens" xref: Reactome:REACT_9987 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3, Homo sapiens" xref: Reactome:REACT_99929 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha, Gallus gallus" xref: Reactome:REACT_99966 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Schizosaccharomyces pombe" xref: Reactome:REACT_9997 "Phosphorylation of Cx43 by c-src, Homo sapiens" is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups relationship: part_of GO:0016310 ! phosphorylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016310 name: phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] subset: goslim_chembl subset: goslim_metagenomics subset: gosubset_prok xref: Wikipedia:Phosphorylation is_a: GO:0006796 ! phosphate-containing compound metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016311 name: dephosphorylation namespace: biological_process def: "The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732] subset: gosubset_prok xref: Wikipedia:Dephosphorylation is_a: GO:0006796 ! phosphate-containing compound metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016407 name: acetyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acetyl group to an acceptor molecule." [GOC:ai] subset: goslim_metagenomics subset: gosubset_prok synonym: "acetylase activity" EXACT [] xref: EC:2.3.1.- xref: Reactome:REACT_108863 "Acetylation of SL1, Bos taurus" xref: Reactome:REACT_110154 "Acetylation of SL1, Mus musculus" xref: Reactome:REACT_115357 "Acetylation of SL1, Xenopus tropicalis" xref: Reactome:REACT_2113 "Acetylation of SL1, Homo sapiens" xref: Reactome:REACT_77536 "Acetylation of SL1, Rattus norvegicus" xref: Reactome:REACT_91894 "Acetylation of SL1, Taeniopygia guttata" xref: Reactome:REACT_96328 "Acetylation of SL1, Canis familiaris" is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016410 name: N-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- xref: Reactome:REACT_6927 "phenylacetyl-CoA + glutamine => phenylacetyl glutamine + Coenzyme A, Homo sapiens" is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016411 name: acylglycerol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- is_a: GO:0008374 ! O-acyltransferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016423 name: tRNA (guanine) methyltransferase activity namespace: molecular_function alt_id: GO:0016424 def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylguanine." [EC:2.1.1.-] subset: gosubset_prok synonym: "tRNA (guanosine) methyltransferase activity" EXACT [] xref: EC:2.1.1.- is_a: GO:0008175 ! tRNA methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016458 name: gene silencing namespace: biological_process def: "Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, postranscriptional repression of gene expression." [GOC:dos, GOC:dph, GOC:jid, GOC:tb] comment: This is a rather broad grouping term. While it was originally defined for long-term, heritable, epigenetic effects, short term effects on expression mediated by RNA are also frequently referred to as gene silencing, and are grouped under this class. subset: goslim_pir synonym: "long-term maintenance of gene inactivation" NARROW [] xref: Wikipedia:Gene_silencing is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0044763 ! single-organism cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016462 name: pyrophosphatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments." [EC:3.6.1.-, GOC:curators] subset: gosubset_prok xref: EC:3.6.1.- is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016482 name: cytoplasmic transport namespace: biological_process def: "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, or within the cytoplasm of a cell." [GOC:ai] synonym: "cytoplasmic streaming" NARROW [] is_a: GO:0046907 ! intracellular transport relationship: occurs_in GO:0005622 ! intracellular property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016485 name: protein processing namespace: biological_process alt_id: GO:0051605 def: "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg] subset: goslim_chembl subset: gosubset_prok synonym: "peptidolysis during protein maturation" RELATED [GOC:mah] synonym: "protein maturation by peptide bond cleavage" EXACT [GOC:bf] synonym: "protein maturation by peptide bond hydrolysis" EXACT [GOC:mah] synonym: "protein maturation by proteolysis" RELATED [GOC:mah] is_a: GO:0006508 ! proteolysis is_a: GO:0051604 ! protein maturation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016491 name: oxidoreductase activity namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] comment: Note that enzymes of class EC:1.97.-.- should also be annotated to this term. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "oxidoreductase activity, acting on other substrates" NARROW [] synonym: "redox activity" EXACT [] xref: EC:1 xref: Reactome:REACT_102858 "Diiodinated tyrosine can be deiodinated, Mus musculus" xref: Reactome:REACT_102973 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Canis familiaris" xref: Reactome:REACT_103874 "Monoiodinated tyrosine can be deiodinated, Canis familiaris" xref: Reactome:REACT_104604 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Danio rerio" xref: Reactome:REACT_105062 "Monoiodinated tyrosine can be deiodinated, Danio rerio" xref: Reactome:REACT_105121 "Monoiodinated tyrosine can be deiodinated, Caenorhabditis elegans" xref: Reactome:REACT_106088 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Rattus norvegicus" xref: Reactome:REACT_106276 "Monoiodinated tyrosine can be deiodinated, Rattus norvegicus" xref: Reactome:REACT_107002 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Sus scrofa" xref: Reactome:REACT_107467 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Rattus norvegicus" xref: Reactome:REACT_108745 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Taeniopygia guttata" xref: Reactome:REACT_109500 "Monoiodinated tyrosine can be deiodinated, Bos taurus" xref: Reactome:REACT_110582 "Diiodinated tyrosine can be deiodinated, Rattus norvegicus" xref: Reactome:REACT_115316 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Drosophila melanogaster" xref: Reactome:REACT_15389 "Monoiodinated tyrosine can be deiodinated, Homo sapiens" xref: Reactome:REACT_15410 "Diiodinated tyrosine can be deiodinated, Homo sapiens" xref: Reactome:REACT_17006 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Homo sapiens" xref: Reactome:REACT_17042 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Homo sapiens" xref: Reactome:REACT_29212 "Diiodinated tyrosine can be deiodinated, Canis familiaris" xref: Reactome:REACT_30160 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Mus musculus" xref: Reactome:REACT_31762 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Gallus gallus" xref: Reactome:REACT_32960 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Bos taurus" xref: Reactome:REACT_34705 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Mus musculus" xref: Reactome:REACT_44470 "Monoiodinated tyrosine can be deiodinated, Mus musculus" xref: Reactome:REACT_78923 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Taeniopygia guttata" xref: Reactome:REACT_84842 "Diiodinated tyrosine can be deiodinated, Gallus gallus" xref: Reactome:REACT_86178 "Monoiodinated tyrosine can be deiodinated, Xenopus tropicalis" xref: Reactome:REACT_88304 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Bos taurus" xref: Reactome:REACT_89057 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Gallus gallus" xref: Reactome:REACT_90394 "Diiodinated tyrosine can be deiodinated, Xenopus tropicalis" xref: Reactome:REACT_91638 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Arabidopsis thaliana" xref: Reactome:REACT_91952 "Monoiodinated tyrosine can be deiodinated, Gallus gallus" xref: Reactome:REACT_92075 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Xenopus tropicalis" xref: Reactome:REACT_92434 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Canis familiaris" xref: Reactome:REACT_93539 "Diiodinated tyrosine can be deiodinated, Drosophila melanogaster" xref: Reactome:REACT_93974 "Diiodinated tyrosine can be deiodinated, Taeniopygia guttata" xref: Reactome:REACT_95169 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2], Danio rerio" xref: Reactome:REACT_95558 "Monoiodinated tyrosine can be deiodinated, Sus scrofa" xref: Reactome:REACT_95573 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Caenorhabditis elegans" xref: Reactome:REACT_97234 "Diiodinated tyrosine can be deiodinated, Caenorhabditis elegans" xref: Reactome:REACT_97568 "Diiodinated tyrosine can be deiodinated, Sus scrofa" xref: Reactome:REACT_97851 "Diiodinated tyrosine can be deiodinated, Bos taurus" xref: Reactome:REACT_98022 "Monoiodinated tyrosine can be deiodinated, Drosophila melanogaster" xref: Reactome:REACT_99085 "palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1], Oryza sativa" xref: Reactome:REACT_99794 "Diiodinated tyrosine can be deiodinated, Danio rerio" xref: Reactome:REACT_99989 "Monoiodinated tyrosine can be deiodinated, Taeniopygia guttata" is_a: GO:0003824 ! catalytic activity relationship: part_of GO:0055114 ! oxidation-reduction process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016567 name: protein ubiquitination namespace: biological_process def: "The process in which one or more ubiquitin groups are added to a protein." [GOC:ai] synonym: "protein ubiquitinylation" EXACT [] synonym: "protein ubiquitylation" EXACT [] is_a: GO:0032446 ! protein modification by small protein conjugation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016568 name: chromatin modification namespace: biological_process def: "The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130] is_a: GO:0006325 ! chromatin organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016569 name: covalent chromatin modification namespace: biological_process def: "The alteration of DNA or protein in chromatin by the covalent addition or removal of chemical groups." [GOC:mah] is_a: GO:0016568 ! chromatin modification property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016570 name: histone modification namespace: biological_process def: "The covalent alteration of one or more amino acid residues within a histone protein." [GOC:krc] subset: goslim_yeast xref: Wikipedia:Histone#Histone_modifications_in_chromatin_regulation is_a: GO:0006464 ! cellular protein modification process is_a: GO:0016569 ! covalent chromatin modification is_a: GO:0044710 ! single-organism metabolic process is_a: GO:1902589 ! single-organism organelle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016571 name: histone methylation namespace: biological_process def: "The modification of histones by addition of methyl groups." [GOC:ai] xref: Wikipedia:Histone_methylation is_a: GO:0006479 ! protein methylation is_a: GO:0016570 ! histone modification property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016572 name: histone phosphorylation namespace: biological_process def: "The modification of histones by addition of phosphate groups." [GOC:ai] is_a: GO:0006468 ! protein phosphorylation is_a: GO:0016570 ! histone modification property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016573 name: histone acetylation namespace: biological_process def: "The modification of a histone by the addition of an acetyl group." [GOC:ai] is_a: GO:0016570 ! histone modification is_a: GO:0018393 ! internal peptidyl-lysine acetylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016574 name: histone ubiquitination namespace: biological_process def: "The modification of histones by addition of ubiquitin groups." [GOC:ai] synonym: "histone ubiquitinylation" EXACT [] synonym: "histone ubiquitylation" EXACT [] is_a: GO:0016567 ! protein ubiquitination is_a: GO:0016570 ! histone modification property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016575 name: histone deacetylation namespace: biological_process def: "The modification of histones by removal of acetyl groups." [GOC:ai] is_a: GO:0006476 ! protein deacetylation is_a: GO:0016570 ! histone modification property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016584 name: nucleosome positioning namespace: biological_process def: "Ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another." [GOC:bf, PMID:11447119, PMID:8676389] synonym: "nucleosome spacing" EXACT [] is_a: GO:0031497 ! chromatin assembly is_a: GO:0034728 ! nucleosome organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016614 name: oxidoreductase activity, acting on CH-OH group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.1.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on the CH-OH group of donors, other acceptors" NARROW [] xref: EC:1.1 is_a: GO:0016491 ! oxidoreductase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016615 name: malate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate." [GOC:mah, ISBN:0582227089] subset: gosubset_prok is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016616 name: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai] subset: gosubset_prok xref: EC:1.1.1 xref: Reactome:REACT_25000 "Reduction of retinal to retinol in enterocytes, Homo sapiens" is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016620 name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] subset: gosubset_prok xref: EC:1.2.1 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016627 name: oxidoreductase activity, acting on the CH-CH group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.3.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on the CH-CH group of donors, other acceptors" NARROW [] xref: EC:1.3 is_a: GO:0016491 ! oxidoreductase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016635 name: oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a quinone or related compound." [GOC:jl] subset: gosubset_prok xref: EC:1.3.5 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016638 name: oxidoreductase activity, acting on the CH-NH2 group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.4.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors" NARROW [] xref: EC:1.4 is_a: GO:0016491 ! oxidoreductase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016639 name: oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai] subset: gosubset_prok xref: EC:1.4.1 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016641 name: oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai] subset: gosubset_prok xref: EC:1.4.3 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016645 name: oxidoreductase activity, acting on the CH-NH group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.5.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on the CH-NH group of donors, other acceptors" NARROW [] xref: EC:1.5 is_a: GO:0016491 ! oxidoreductase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016646 name: oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] subset: gosubset_prok xref: EC:1.5.1 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016651 name: oxidoreductase activity, acting on NAD(P)H namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.6.99.- should also be annotated to this term. subset: gosubset_prok synonym: "NAD(P)H dehydrogenase" NARROW [] synonym: "oxidoreductase activity, acting on NADH or NADPH" RELATED [] synonym: "oxidoreductase activity, acting on NADH or NADPH, other acceptor" NARROW [] xref: EC:1.6 xref: Reactome:REACT_101516 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Taeniopygia guttata" xref: Reactome:REACT_108125 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Sus scrofa" xref: Reactome:REACT_164 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Homo sapiens" xref: Reactome:REACT_32648 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Mus musculus" xref: Reactome:REACT_79787 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Rattus norvegicus" xref: Reactome:REACT_81411 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Xenopus tropicalis" xref: Reactome:REACT_87412 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Danio rerio" xref: Reactome:REACT_87857 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Bos taurus" xref: Reactome:REACT_87883 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Gallus gallus" xref: Reactome:REACT_89599 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Caenorhabditis elegans" xref: Reactome:REACT_94209 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA, Canis familiaris" is_a: GO:0016491 ! oxidoreductase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016653 name: oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a heme protein." [GOC:ai] subset: gosubset_prok synonym: "oxidoreductase activity, acting on NADH or NADPH, haem protein as acceptor" EXACT [] synonym: "oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor" RELATED [] xref: EC:1.6.2 is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016655 name: oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule." [GOC:ai] subset: gosubset_prok synonym: "oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor" RELATED [] xref: EC:1.6.5 is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016667 name: oxidoreductase activity, acting on a sulfur group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.8.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on sulfur group of donors, other acceptors" NARROW [] synonym: "oxidoreductase activity, acting on sulphur group of donors" EXACT [] xref: EC:1.8 is_a: GO:0016491 ! oxidoreductase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016668 name: oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor namespace: molecular_function alt_id: GO:0016654 def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] subset: gosubset_prok synonym: "oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor" RELATED [] synonym: "oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor" EXACT [] synonym: "oxidoreductase activity, acting on NADH or NADPH, disulphide as acceptor" EXACT [] synonym: "oxidoreductase activity, acting on sulphur group of donors, NAD or NADP as acceptor" EXACT [] xref: EC:1.8.1 is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016672 name: oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces quinone or a related compound." [GOC:jl] subset: gosubset_prok synonym: "oxidoreductase activity, acting on sulphur group of donors, quinone or similar compound as acceptor" EXACT [] xref: EC:1.8.5 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016675 name: oxidoreductase activity, acting on a heme group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.9.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on haem group of donors" EXACT [] synonym: "oxidoreductase activity, acting on heme group of donors, other acceptors" NARROW [] xref: EC:1.9 is_a: GO:0016491 ! oxidoreductase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016676 name: oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] subset: gosubset_prok synonym: "oxidoreductase activity, acting on haem group of donors, oxygen as acceptor" EXACT [] xref: EC:1.9.3 is_a: GO:0016675 ! oxidoreductase activity, acting on a heme group of donors property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016679 name: oxidoreductase activity, acting on diphenols and related substances as donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.10.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors" NARROW [] xref: EC:1.10 is_a: GO:0016491 ! oxidoreductase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016681 name: oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl] subset: gosubset_prok xref: EC:1.10.2 is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016684 name: oxidoreductase activity, acting on peroxide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor." [GOC:ai] subset: gosubset_prok xref: EC:1.11 is_a: GO:0016491 ! oxidoreductase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016721 name: oxidoreductase activity, acting on superoxide radicals as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a superoxide radical (O2- or O2.-) acts as a hydrogen or electron acceptor." [GOC:ai] subset: gosubset_prok xref: EC:1.15 is_a: GO:0016491 ! oxidoreductase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016722 name: oxidoreductase activity, oxidizing metal ions namespace: molecular_function def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered." [GOC:mah] subset: gosubset_prok xref: EC:1.16 xref: Reactome:REACT_25114 "Reduction of extracellular Fe3+, Homo sapiens" is_a: GO:0016491 ! oxidoreductase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016723 name: oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and NAD+ or NADP+ acts as an electron acceptor." [GOC:mah] subset: gosubset_prok xref: EC:1.16.1 xref: Reactome:REACT_24919 "Reduction of Fe3+ in the endosome, Homo sapiens" is_a: GO:0016722 ! oxidoreductase activity, oxidizing metal ions property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016740 name: transferase activity namespace: molecular_function def: "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: EC:2 xref: Reactome:REACT_25050 "Molybdenum ion transfer onto molybdopterin, Homo sapiens" is_a: GO:0003824 ! catalytic activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016741 name: transferase activity, transferring one-carbon groups namespace: molecular_function def: "Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] subset: gosubset_prok xref: EC:2.1 is_a: GO:0016740 ! transferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016742 name: hydroxymethyl-, formyl- and related transferase activity namespace: molecular_function def: "Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor)." [EC:2.1.2, GOC:mah] subset: gosubset_prok xref: EC:2.1.2 is_a: GO:0016741 ! transferase activity, transferring one-carbon groups property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016743 name: carboxyl- or carbamoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor)." [GOC:jl] subset: gosubset_prok synonym: "carboxyl- and carbamoyltransferase activity" EXACT [] xref: EC:2.1.3 is_a: GO:0016741 ! transferase activity, transferring one-carbon groups property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016746 name: transferase activity, transferring acyl groups namespace: molecular_function alt_id: GO:0008415 def: "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: gosubset_prok synonym: "acyltransferase activity" EXACT [] xref: EC:2.3 is_a: GO:0016740 ! transferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016747 name: transferase activity, transferring acyl groups other than amino-acyl groups namespace: molecular_function def: "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl] subset: gosubset_prok synonym: "transferase activity, transferring groups other than amino-acyl groups" EXACT [EC:2.3.1] xref: EC:2.3.1 is_a: GO:0016746 ! transferase activity, transferring acyl groups property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016755 name: transferase activity, transferring amino-acyl groups namespace: molecular_function def: "Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl] subset: gosubset_prok synonym: "aminoacyltransferase activity" EXACT [] xref: EC:2.3.2 is_a: GO:0016746 ! transferase activity, transferring acyl groups property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016756 name: glutathione gamma-glutamylcysteinyltransferase activity namespace: molecular_function alt_id: GO:0042143 def: "Catalysis of the reaction: glutathione + Glu(-Cys)(n)-Gly = Gly + Glu(-Cys)(n+1)-Gly." [EC:2.3.2.15] synonym: "gamma-glutamylcysteine dipeptidyl transpeptidase activity" EXACT [EC:2.3.2.15] synonym: "glutathione:poly(4-glutamyl-cysteinyl)glycine 4-glutamylcysteinyltransferase activity" EXACT [EC:2.3.2.15] synonym: "phytochelatin synthase activity" EXACT [EC:2.3.2.15] xref: EC:2.3.2.15 xref: MetaCyc:2.3.2.15-RXN is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016757 name: transferase activity, transferring glycosyl groups namespace: molecular_function alt_id: GO:0016932 def: "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] comment: Note that enzymes of class EC:2.4.99.- should also be annotated to this term. subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast subset: gosubset_prok synonym: "glycosyltransferase activity" EXACT [] synonym: "transferase activity, transferring other glycosyl groups" NARROW [] synonym: "transglycosidase activity" EXACT [] synonym: "transglycosylase activity" EXACT [] xref: EC:2.4 is_a: GO:0016740 ! transferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016758 name: transferase activity, transferring hexosyl groups namespace: molecular_function def: "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl] subset: gosubset_prok synonym: "hexosyltransferase activity" EXACT [] xref: EC:2.4.1 is_a: GO:0016757 ! transferase activity, transferring glycosyl groups property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016765 name: transferase activity, transferring alkyl or aryl (other than methyl) groups namespace: molecular_function alt_id: GO:0016766 def: "Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: gosubset_prok synonym: "transferase activity, transferring alkyl or aryl groups, other than methyl groups" EXACT [] xref: EC:2.5 xref: EC:2.5.1 is_a: GO:0016740 ! transferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016772 name: transferase activity, transferring phosphorus-containing groups namespace: molecular_function def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] comment: Note that this term encompasses all kinase activities, as well as activities that transfer other phosphorus-containing groups such as diphosphate or nucleotides. subset: goslim_chembl subset: gosubset_prok xref: EC:2.7 is_a: GO:0016740 ! transferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016773 name: phosphotransferase activity, alcohol group as acceptor namespace: molecular_function def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl] subset: gosubset_prok xref: EC:2.7.1 is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016776 name: phosphotransferase activity, phosphate group as acceptor namespace: molecular_function def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor)." [GOC:jl] subset: gosubset_prok xref: EC:2.7.4 is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016778 name: diphosphotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a diphosphate group from one compound (donor) to a another (acceptor)." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html] subset: gosubset_prok xref: EC:2.7.6 is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016779 name: nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_yeast subset: gosubset_prok xref: EC:2.7.7 is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016780 name: phosphotransferase activity, for other substituted phosphate groups namespace: molecular_function def: "Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html] subset: gosubset_prok xref: EC:2.7.8 xref: Reactome:REACT_100707 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI, Dictyostelium discoideum" xref: Reactome:REACT_100805 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI, Mus musculus" xref: Reactome:REACT_101325 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Caenorhabditis elegans" xref: Reactome:REACT_102194 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI, Taeniopygia guttata" xref: Reactome:REACT_102635 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI, Arabidopsis thaliana" xref: Reactome:REACT_103177 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI, Danio rerio" xref: Reactome:REACT_103738 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol, Rattus norvegicus" xref: Reactome:REACT_104119 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Dictyostelium discoideum" xref: Reactome:REACT_104945 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol, Gallus gallus" xref: Reactome:REACT_105069 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Gallus gallus" xref: Reactome:REACT_105152 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI, Xenopus tropicalis" xref: Reactome:REACT_105178 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Rattus norvegicus" xref: Reactome:REACT_106366 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Schizosaccharomyces pombe" xref: Reactome:REACT_106435 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Oryza sativa" xref: Reactome:REACT_109665 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Danio rerio" xref: Reactome:REACT_110345 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol, Bos taurus" xref: Reactome:REACT_111955 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Xenopus tropicalis" xref: Reactome:REACT_113237 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI, Saccharomyces cerevisiae" xref: Reactome:REACT_113436 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol, Saccharomyces cerevisiae" xref: Reactome:REACT_114047 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Drosophila melanogaster" xref: Reactome:REACT_155 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI, Homo sapiens" xref: Reactome:REACT_1802 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol, Mus musculus" xref: Reactome:REACT_2043 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol, Homo sapiens" xref: Reactome:REACT_28634 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol, Xenopus tropicalis" xref: Reactome:REACT_28716 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol, Drosophila melanogaster" xref: Reactome:REACT_31213 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI, Oryza sativa" xref: Reactome:REACT_31672 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI, Drosophila melanogaster" xref: Reactome:REACT_32683 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Sus scrofa" xref: Reactome:REACT_32755 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol, Canis familiaris" xref: Reactome:REACT_464 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Homo sapiens" xref: Reactome:REACT_78148 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI, Gallus gallus" xref: Reactome:REACT_79457 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI, Canis familiaris" xref: Reactome:REACT_81401 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol, Taeniopygia guttata" xref: Reactome:REACT_82563 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol, Danio rerio" xref: Reactome:REACT_83736 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Saccharomyces cerevisiae" xref: Reactome:REACT_84128 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol, Sus scrofa" xref: Reactome:REACT_85210 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI, Bos taurus" xref: Reactome:REACT_85552 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol, Arabidopsis thaliana" xref: Reactome:REACT_85730 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI, Rattus norvegicus" xref: Reactome:REACT_88786 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol, Oryza sativa" xref: Reactome:REACT_89071 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Taeniopygia guttata" xref: Reactome:REACT_92140 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Canis familiaris" xref: Reactome:REACT_94510 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Mus musculus" xref: Reactome:REACT_98160 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Bos taurus" xref: Reactome:REACT_99847 "mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol, Arabidopsis thaliana" xref: Reactome:REACT_99956 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol, Dictyostelium discoideum" is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016787 name: hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: EC:3 xref: Reactome:REACT_110436 "Hydrolysis of phosphatidylcholine, Bos taurus" xref: Reactome:REACT_111159 "Partial proteolysis of antigen in phagolysosomes, Homo sapiens" xref: Reactome:REACT_15331 "Hydrolysis of phosphatidylcholine, Homo sapiens" xref: Reactome:REACT_83734 "Hydrolysis of phosphatidylcholine, Danio rerio" xref: Reactome:REACT_84047 "Hydrolysis of phosphatidylcholine, Xenopus tropicalis" xref: Reactome:REACT_87959 "Hydrolysis of phosphatidylcholine, Gallus gallus" xref: Reactome:REACT_88159 "Hydrolysis of phosphatidylcholine, Canis familiaris" xref: Reactome:REACT_90118 "Hydrolysis of phosphatidylcholine, Mus musculus" xref: Reactome:REACT_91045 "Hydrolysis of phosphatidylcholine, Taeniopygia guttata" xref: Reactome:REACT_98572 "Hydrolysis of phosphatidylcholine, Rattus norvegicus" is_a: GO:0003824 ! catalytic activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016788 name: hydrolase activity, acting on ester bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any ester bond." [GOC:jl] subset: goslim_chembl subset: goslim_metagenomics subset: gosubset_prok synonym: "esterase activity" EXACT [] xref: EC:3.1 xref: Reactome:REACT_106563 "Deacylation of Acyl Ghrelin, Mus musculus" xref: Reactome:REACT_109748 "Deacylation of Acyl Ghrelin, Bos taurus" xref: Reactome:REACT_112177 "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Xenopus tropicalis" xref: Reactome:REACT_19294 "Deacylation of Acyl Ghrelin, Homo sapiens" xref: Reactome:REACT_1978 "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Homo sapiens" xref: Reactome:REACT_45174 "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Mus musculus" xref: Reactome:REACT_77112 "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Danio rerio" xref: Reactome:REACT_81282 "Deacylation of Acyl Ghrelin, Rattus norvegicus" xref: Reactome:REACT_83347 "Deacylation of Acyl Ghrelin, Gallus gallus" xref: Reactome:REACT_88228 "Deacylation of Acyl Ghrelin, Canis familiaris" xref: Reactome:REACT_88314 "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Sus scrofa" xref: Reactome:REACT_89615 "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Rattus norvegicus" xref: Reactome:REACT_92446 "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Canis familiaris" xref: Reactome:REACT_94475 "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid, Bos taurus" is_a: GO:0016787 ! hydrolase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016791 name: phosphatase activity namespace: molecular_function alt_id: GO:0003869 alt_id: GO:0016302 def: "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast subset: gosubset_prok synonym: "4-nitrophenylphosphatase activity" NARROW [] synonym: "4-nitrophenylphosphate phosphohydrolase activity" NARROW [EC:3.1.3.41] synonym: "ecto-p-nitrophenyl phosphatase activity" NARROW [EC:3.1.3.41] synonym: "K-pNPPase activity" NARROW [EC:3.1.3.41] synonym: "nitrophenyl phosphatase activity" NARROW [EC:3.1.3.41] synonym: "NPPase activity" NARROW [EC:3.1.3.41] synonym: "p-nitrophenylphosphatase activity" NARROW [EC:3.1.3.41] synonym: "p-nitrophenylphosphate phosphohydrolase activity" NARROW [EC:3.1.3.41] synonym: "para-nitrophenyl phosphatase activity" NARROW [EC:3.1.3.41] synonym: "phosphatase" RELATED [] synonym: "phosphoric monoester hydrolase activity" EXACT [] synonym: "PNPPase activity" NARROW [EC:3.1.3.41] xref: EC:3.1.3 xref: EC:3.1.3.41 xref: MetaCyc:4-NITROPHENYLPHOSPHATASE-RXN xref: RHEA:21667 is_a: GO:0042578 ! phosphoric ester hydrolase activity relationship: part_of GO:0006470 ! protein dephosphorylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016796 name: exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:mah] comment: Note that this activity can catalyze cleavage of DNA or RNA. subset: gosubset_prok synonym: "exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5' phosphomonoesters" EXACT [] xref: EC:3.1.15 is_a: GO:0004527 ! exonuclease activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016798 name: hydrolase activity, acting on glycosyl bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast subset: gosubset_prok synonym: "glycosidase activity" EXACT [] synonym: "glycosylase" NARROW [] synonym: "N-glycosylase" NARROW [] xref: EC:3.2 is_a: GO:0016787 ! hydrolase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016799 name: hydrolase activity, hydrolyzing N-glycosyl compounds namespace: molecular_function def: "Catalysis of the hydrolysis of any N-glycosyl bond." [GOC:jl] subset: gosubset_prok xref: EC:3.2.2 is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016810 name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl] comment: Note that enzymes of class EC:3.5.99.- should also be annotated to this term. subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: gosubset_prok synonym: "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds" NARROW [] xref: EC:3.5 xref: Reactome:REACT_27208 "acetylglucosamine-inositol is deacetylated by Mca, Mycobacterium tuberculosis" is_a: GO:0016787 ! hydrolase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016811 name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides namespace: molecular_function def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai] subset: gosubset_prok xref: EC:3.5.1 xref: Reactome:REACT_27249 "mycothiol is cleaved to acetylcysteine and glucosaminylinositol, Mycobacterium tuberculosis" xref: Reactome:REACT_27304 "mycothiol S-conjugate is cleaved into mercapturic acid and GlcN-Ins, Mycobacterium tuberculosis" is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016814 name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines namespace: molecular_function def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2." [ISBN:0198506732] subset: gosubset_prok xref: EC:3.5.4 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016817 name: hydrolase activity, acting on acid anhydrides namespace: molecular_function def: "Catalysis of the hydrolysis of any acid anhydride." [GOC:jl] subset: gosubset_prok synonym: "hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement" NARROW [] xref: EC:3.6 is_a: GO:0016787 ! hydrolase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016818 name: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides namespace: molecular_function def: "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl] subset: gosubset_prok xref: EC:3.6.1 is_a: GO:0016817 ! hydrolase activity, acting on acid anhydrides property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016820 name: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances namespace: molecular_function def: "Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane." [GOC:mah] subset: gosubset_prok xref: EC:3.6.3 is_a: GO:0016817 ! hydrolase activity, acting on acid anhydrides is_a: GO:0022857 ! transmembrane transporter activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016829 name: lyase activity namespace: molecular_function def: "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684] comment: Note that enzymes of class EC:4.99.-.- should also be annotated to this term. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "other lyase activity" NARROW [] xref: EC:4 is_a: GO:0003824 ! catalytic activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016835 name: carbon-oxygen lyase activity namespace: molecular_function def: "Catalysis of the breakage of a carbon-oxygen bond." [EC:4.2.-.-] comment: Note that enzymes of class EC:4.2.99.- should also be annotated to this term. subset: gosubset_prok synonym: "other carbon-oxygen lyase activity" NARROW [] xref: EC:4.2 is_a: GO:0016829 ! lyase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016836 name: hydro-lyase activity namespace: molecular_function def: "Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1] subset: gosubset_prok xref: EC:4.2.1 is_a: GO:0016835 ! carbon-oxygen lyase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016849 name: phosphorus-oxygen lyase activity namespace: molecular_function def: "Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl] subset: gosubset_prok xref: EC:4.6 is_a: GO:0016829 ! lyase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016853 name: isomerase activity namespace: molecular_function def: "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] comment: Note that enzymes of class EC:5.99.-.- should also be annotated to this term. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "other isomerase activity" NARROW [] xref: EC:5 is_a: GO:0003824 ! catalytic activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016866 name: intramolecular transferase activity namespace: molecular_function def: "Catalysis of the transfer of a functional group from one position to another within a single molecule." [GOC:mah] comment: Note that enzymes of class EC:5.4.99.- should also be annotated to this term. subset: gosubset_prok synonym: "intramolecular transferase activity, transferring other groups" NARROW [] synonym: "mutase activity" EXACT [] xref: EC:5.4 is_a: GO:0016853 ! isomerase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016867 name: intramolecular transferase activity, transferring acyl groups namespace: molecular_function def: "Catalysis of the transfer of an acyl group from one position to another within a single molecule." [GOC:mah] subset: gosubset_prok xref: EC:5.4.1 is_a: GO:0016866 ! intramolecular transferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016868 name: intramolecular transferase activity, phosphotransferases namespace: molecular_function alt_id: GO:0016777 def: "Catalysis of the transfer of a phosphate group from one position to another within a single molecule." [GOC:mah] subset: gosubset_prok synonym: "phosphomutase activity" EXACT [] synonym: "phosphotransferase activity, with regeneration of donors, apparently catalyzing intramolecular transfers" EXACT [] xref: EC:5.4.2 is_a: GO:0016866 ! intramolecular transferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016874 name: ligase activity namespace: molecular_function def: "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "synthetase activity" EXACT [GOC:jh2] xref: EC:6 xref: Reactome:REACT_115603 "Ligation of DNA at sites of patch replacement, Gallus gallus" xref: Reactome:REACT_116018 "Ligation of newly synthesized repair patch to incised DNA in GG-NER, Gallus gallus" is_a: GO:0003824 ! catalytic activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016877 name: ligase activity, forming carbon-sulfur bonds namespace: molecular_function def: "Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.2, GOC:mah] subset: gosubset_prok synonym: "ligase activity, forming carbon-sulphur bonds" EXACT [] xref: EC:6.2 is_a: GO:0016874 ! ligase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016879 name: ligase activity, forming carbon-nitrogen bonds namespace: molecular_function def: "Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.3, GOC:mah] comment: Note that enzymes of class EC:6.3.4.- should also be annotated to this term. subset: gosubset_prok synonym: "other carbon-nitrogen ligase activity" NARROW [] xref: EC:6.3 is_a: GO:0016874 ! ligase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016880 name: acid-ammonia (or amide) ligase activity namespace: molecular_function def: "Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah] subset: gosubset_prok synonym: "amide synthase activity" EXACT [] xref: EC:6.3.1 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016881 name: acid-amino acid ligase activity namespace: molecular_function def: "Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah] subset: gosubset_prok synonym: "peptide synthase activity" EXACT [] xref: EC:6.3.2 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016882 name: cyclo-ligase activity namespace: molecular_function def: "Catalysis of the joining of two groups within a single molecule via a carbon-nitrogen bond, forming heterocyclic ring, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.3.3.1, EC:6.3.3.2, EC:6.3.3.4, GOC:jl, GOC:mah] subset: gosubset_prok xref: EC:6.3.3 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016887 name: ATPase activity namespace: molecular_function alt_id: GO:0004002 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast subset: gosubset_prok synonym: "(Ca2+ + Mg2+)-ATPase" NARROW [EC:3.6.1.3] synonym: "adenosine 5'-triphosphatase activity" EXACT [EC:3.6.1.3] synonym: "adenosine triphosphatase activity" EXACT [EC:3.6.1.3] synonym: "adenosinetriphosphatase activity" EXACT [] synonym: "ATP hydrolase activity" EXACT [EC:3.6.1.3] synonym: "ATP monophosphatase activity" EXACT [EC:3.6.1.3] synonym: "ATP phosphohydrolase activity" EXACT [] synonym: "complex V (mitochondrial electron transport)" RELATED [EC:3.6.1.3] synonym: "HCO3--ATPase" NARROW [EC:3.6.1.3] synonym: "SV40 T-antigen" RELATED [EC:3.6.1.3] xref: EC:3.6.1.3 xref: MetaCyc:ADENOSINETRIPHOSPHATASE-RXN xref: Reactome:REACT_100141 "Trafficking of GluR2-containing AMPA receptors to synapse, Canis familiaris" xref: Reactome:REACT_108873 "Trafficking of GluR2-containing AMPA receptors to synapse, Bos taurus" xref: Reactome:REACT_110992 "Trafficking of GluR2-containing AMPA receptors to synapse, Danio rerio" xref: Reactome:REACT_113271 "Trafficking of GluR2-containing AMPA receptors to synapse, Xenopus tropicalis" xref: Reactome:REACT_18320 "Trafficking of GluR2-containing AMPA receptors to synapse, Homo sapiens" xref: Reactome:REACT_27184 "ESCRT Disassembly, Homo sapiens" xref: Reactome:REACT_33329 "Trafficking of GluR2-containing AMPA receptors to synapse, Gallus gallus" xref: Reactome:REACT_79964 "Trafficking of GluR2-containing AMPA receptors to synapse, Mus musculus" xref: Reactome:REACT_84196 "Trafficking of GluR2-containing AMPA receptors to synapse, Drosophila melanogaster" xref: Reactome:REACT_87020 "Trafficking of GluR2-containing AMPA receptors to synapse, Rattus norvegicus" xref: Reactome:REACT_89934 "Trafficking of GluR2-containing AMPA receptors to synapse, Taeniopygia guttata" xref: RHEA:13068 is_a: GO:0017111 ! nucleoside-triphosphatase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016889 name: endodeoxyribonuclease activity, producing 3'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:ai] subset: gosubset_prok synonym: "endodeoxyribonuclease activity, producing other than 5'-phosphomonoesters" EXACT [] xref: EC:3.1.22 is_a: GO:0004520 ! endodeoxyribonuclease activity is_a: GO:0016894 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016890 name: site-specific endodeoxyribonuclease activity, specific for altered base namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages at specific sites within a deoxyribonucleic acid molecule by creating internal breaks." [GOC:jl] subset: gosubset_prok xref: EC:3.1.25 is_a: GO:0004520 ! endodeoxyribonuclease activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016894 name: endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:mah] comment: Note that this activity can catalyze cleavage of DNA or RNA. subset: gosubset_prok synonym: "3'-endonuclease activity" EXACT [] synonym: "endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters" RELATED [] xref: EC:3.1.31 is_a: GO:0004519 ! endonuclease activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016895 name: exodeoxyribonuclease activity, producing 5'-phosphomonoesters namespace: molecular_function alt_id: GO:0008858 def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:ai] subset: gosubset_prok synonym: "exodeoxyribonuclease activity, producing 5' phosphomonoesters" EXACT [] synonym: "exonuclease VIII activity" NARROW [] xref: EC:3.1.11 is_a: GO:0004529 ! exodeoxyribonuclease activity is_a: GO:0016796 ! exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016896 name: exoribonuclease activity, producing 5'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:ai] subset: gosubset_prok synonym: "exoribonuclease activity, producing 5' phosphomonoesters" EXACT [] xref: EC:3.1.13 xref: Reactome:REACT_109371 "Decapping of mRNA by the DCP1-DCP2 Complex, Xenopus tropicalis" xref: Reactome:REACT_20560 "Decapping of mRNA by the DCP1-DCP2 Complex, Homo sapiens" xref: Reactome:REACT_81094 "Decapping of mRNA by the DCP1-DCP2 Complex, Taeniopygia guttata" xref: Reactome:REACT_89209 "Decapping of mRNA by the DCP1-DCP2 Complex, Bos taurus" xref: Reactome:REACT_90720 "Decapping of mRNA by the DCP1-DCP2 Complex, Mus musculus" xref: Reactome:REACT_92855 "Decapping of mRNA by the DCP1-DCP2 Complex, Gallus gallus" xref: Reactome:REACT_93863 "Decapping of mRNA by the DCP1-DCP2 Complex, Danio rerio" xref: Reactome:REACT_97640 "Decapping of mRNA by the DCP1-DCP2 Complex, Canis familiaris" xref: Reactome:REACT_98936 "Decapping of mRNA by the DCP1-DCP2 Complex, Drosophila melanogaster" is_a: GO:0004532 ! exoribonuclease activity is_a: GO:0016796 ! exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016903 name: oxidoreductase activity, acting on the aldehyde or oxo group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.2.99.- should also be annotated to this term. subset: gosubset_prok synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors" NARROW [] xref: EC:1.2 is_a: GO:0016491 ! oxidoreductase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016925 name: protein sumoylation namespace: biological_process alt_id: GO:0006485 alt_id: GO:0016927 def: "The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein." [GOC:jl, PMID:11265250] synonym: "protein sumolation" EXACT [] synonym: "small ubiquitin-related protein 1 conjugation" EXACT [] synonym: "SUMO-protein conjugation" EXACT [] synonym: "sumoylation" EXACT [] xref: Wikipedia:SUMO_protein is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0032446 ! protein modification by small protein conjugation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0016973 name: poly(A)+ mRNA export from nucleus namespace: biological_process def: "The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm." [GOC:ai] synonym: "poly(A) mRNA export from nucleus" EXACT [] synonym: "poly(A)+ mRNA export from cell nucleus" EXACT [] synonym: "poly(A)+ mRNA export out of nucleus" EXACT [] synonym: "poly(A)+ mRNA transport from nucleus to cytoplasm" EXACT [] synonym: "poly(A)+ mRNA-nucleus export" EXACT [] synonym: "polyadenylated mRNA export from nucleus" RELATED [] is_a: GO:0006406 ! mRNA export from nucleus is_a: GO:1902582 ! single-organism intracellular transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0017038 name: protein import namespace: biological_process def: "The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event." [GOC:ai] subset: gosubset_prok synonym: "protein uptake" EXACT [] is_a: GO:0015031 ! protein transport is_a: GO:0044765 ! single-organism transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0017076 name: purine nucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with purine nucleotides, any compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai] subset: gosubset_prok is_a: GO:0000166 ! nucleotide binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0017110 name: nucleoside-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate." [EC:3.6.1.6] synonym: "apyrase activity" BROAD [] synonym: "IDPase" NARROW [EC:3.6.1.6] synonym: "inosine 5'-diphosphatase" NARROW [EC:3.6.1.6] synonym: "inosine diphosphatase" NARROW [EC:3.6.1.6] synonym: "NDPase activity" EXACT [EC:3.6.1.6] synonym: "nucleoside 5'-diphosphatase activity" EXACT [EC:3.6.1.6] synonym: "nucleoside diphosphatase activity" EXACT [] synonym: "nucleoside diphosphate phosphatase activity" EXACT [EC:3.6.1.6] synonym: "nucleoside diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.6] synonym: "nucleoside-diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.6] synonym: "type B nucleoside diphosphatase" NARROW [EC:3.6.1.6] synonym: "type L nucleoside diphosphatase" NARROW [EC:3.6.1.6] xref: EC:3.6.1.6 xref: MetaCyc:NUCLEOSIDE-DIPHOSPHATASE-RXN is_a: GO:0016462 ! pyrophosphatase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0017111 name: nucleoside-triphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] subset: goslim_chembl subset: gosubset_prok synonym: "apyrase activity" BROAD [] synonym: "NTPase activity" EXACT [EC:3.6.1.15] synonym: "nucleoside 5-triphosphatase activity" EXACT [EC:3.6.1.15] synonym: "nucleoside triphosphatase activity" EXACT [] synonym: "nucleoside triphosphate hydrolase activity" EXACT [EC:3.6.1.15] synonym: "nucleoside triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.15] synonym: "nucleoside-5-triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.15] synonym: "unspecific diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.15] xref: EC:3.6.1.15 xref: MetaCyc:NUCLEOSIDE-TRIPHOSPHATASE-RXN xref: RHEA:23683 is_a: GO:0016462 ! pyrophosphatase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0017169 name: CDP-alcohol phosphatidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP + alcohol = CMP + phosphatidyl alcohol." [GOC:ai] subset: gosubset_prok is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0018022 name: peptidyl-lysine methylation namespace: biological_process def: "The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative." [GOC:ai] subset: gosubset_prok is_a: GO:0006479 ! protein methylation is_a: GO:0018205 ! peptidyl-lysine modification property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0018023 name: peptidyl-lysine trimethylation namespace: biological_process def: "The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine." [RESID:AA0074] subset: gosubset_prok xref: RESID:AA0074 is_a: GO:0018022 ! peptidyl-lysine methylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0018024 name: histone-lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [EC:2.1.1.43, RESID:AA0074, RESID:AA0075, RESID:AA0076] synonym: "histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase activity" EXACT [EC:2.1.1.43] synonym: "histone-lysine N-methylase activity" EXACT [GOC:mah] synonym: "protein (lysine) methyltransferase activity" EXACT [EC:2.1.1.43] synonym: "protein methylase 3 activity" NARROW [EC:2.1.1.43] synonym: "protein methylase III activity" NARROW [EC:2.1.1.43] synonym: "protein methyltransferase II activity" NARROW [EC:2.1.1.43] synonym: "S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.43] synonym: "S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.43] xref: EC:2.1.1.43 xref: MetaCyc:HISTONE-LYSINE-N-METHYLTRANSFERASE-RXN xref: RESID:AA0074 xref: RESID:AA0075 xref: RESID:AA0076 is_a: GO:0016279 ! protein-lysine N-methyltransferase activity is_a: GO:0042054 ! histone methyltransferase activity relationship: part_of GO:0034968 ! histone lysine methylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0018026 name: peptidyl-lysine monomethylation namespace: biological_process def: "The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine." [RESID:AA0076] subset: gosubset_prok xref: RESID:AA0076 is_a: GO:0018022 ! peptidyl-lysine methylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0018027 name: peptidyl-lysine dimethylation namespace: biological_process def: "The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine." [RESID:AA0075] subset: gosubset_prok xref: RESID:AA0075 is_a: GO:0018022 ! peptidyl-lysine methylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0018105 name: peptidyl-serine phosphorylation namespace: biological_process def: "The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037] subset: gosubset_prok xref: RESID:AA0037 is_a: GO:0006468 ! protein phosphorylation is_a: GO:0018209 ! peptidyl-serine modification property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0018107 name: peptidyl-threonine phosphorylation namespace: biological_process def: "The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [RESID:AA0038] subset: gosubset_prok xref: RESID:AA0038 is_a: GO:0006468 ! protein phosphorylation is_a: GO:0018210 ! peptidyl-threonine modification property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0018108 name: peptidyl-tyrosine phosphorylation namespace: biological_process def: "The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039] subset: gosubset_prok xref: RESID:AA0039 is_a: GO:0006468 ! protein phosphorylation is_a: GO:0018212 ! peptidyl-tyrosine modification property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0018130 name: heterocycle biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198547684] subset: gosubset_prok synonym: "heterocycle anabolism" EXACT [] synonym: "heterocycle biosynthesis" EXACT [] synonym: "heterocycle formation" EXACT [] synonym: "heterocycle synthesis" EXACT [] is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0046483 ! heterocycle metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0018158 name: protein oxidation namespace: biological_process def: "The modification of a protein amino acid by oxidation." [GOC:ai] subset: gosubset_prok synonym: "protein amino acid oxidation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process is_a: GO:0044763 ! single-organism cellular process is_a: GO:0055114 ! oxidation-reduction process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0018193 name: peptidyl-amino acid modification namespace: biological_process def: "The alteration of an amino acid residue in a peptide." [GOC:mah] subset: goslim_yeast subset: gosubset_prok is_a: GO:0006464 ! cellular protein modification process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0018205 name: peptidyl-lysine modification namespace: biological_process def: "The modification of peptidyl-lysine." [GOC:go_curators] subset: gosubset_prok is_a: GO:0018193 ! peptidyl-amino acid modification property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0018209 name: peptidyl-serine modification namespace: biological_process def: "The modification of peptidyl-serine." [GOC:go_curators] subset: gosubset_prok is_a: GO:0018193 ! peptidyl-amino acid modification property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0018210 name: peptidyl-threonine modification namespace: biological_process def: "The modification of peptidyl-threonine." [GOC:go_curators] subset: gosubset_prok is_a: GO:0018193 ! peptidyl-amino acid modification property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0018212 name: peptidyl-tyrosine modification namespace: biological_process def: "The modification of peptidyl-tyrosine." [GOC:go_curators] subset: gosubset_prok is_a: GO:0018193 ! peptidyl-amino acid modification property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0018345 name: protein palmitoylation namespace: biological_process alt_id: GO:0018318 alt_id: GO:0018349 def: "The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806] subset: gosubset_prok synonym: "protein amino acid palmitoylation" EXACT [GOC:bf] is_a: GO:0006497 ! protein lipidation is_a: GO:0043543 ! protein acylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0018393 name: internal peptidyl-lysine acetylation namespace: biological_process def: "The addition of an acetyl group to a non-terminal lysine residue in a protein." [GOC:mah] subset: gosubset_prok is_a: GO:0006475 ! internal protein amino acid acetylation is_a: GO:0018394 ! peptidyl-lysine acetylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0018394 name: peptidyl-lysine acetylation namespace: biological_process def: "The acetylation of peptidyl-lysine." [GOC:mah] subset: gosubset_prok is_a: GO:0006473 ! protein acetylation is_a: GO:0018205 ! peptidyl-lysine modification property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019001 name: guanyl nucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate." [ISBN:0198506732] subset: gosubset_prok xref: Reactome:REACT_102579 "eEF1A complexes with GTP, Dictyostelium discoideum" xref: Reactome:REACT_106634 "eEF1A complexes with GTP, Saccharomyces cerevisiae" xref: Reactome:REACT_108817 "eEF1A complexes with GTP, Mus musculus" xref: Reactome:REACT_145 "reEF1A complexes with GTP, Oryctolagus cuniculus" xref: Reactome:REACT_31933 "eEF1A complexes with GTP, Danio rerio" xref: Reactome:REACT_80017 "eEF1A complexes with GTP, Canis familiaris" xref: Reactome:REACT_86336 "eEF1A complexes with GTP, Bos taurus" xref: Reactome:REACT_87166 "eEF1A complexes with GTP, Plasmodium falciparum" xref: Reactome:REACT_88634 "eEF1A complexes with GTP, Schizosaccharomyces pombe" xref: Reactome:REACT_90 "eEF1A complexes with GTP, Homo sapiens" xref: Reactome:REACT_95879 "eEF1A complexes with GTP, Gallus gallus" xref: Reactome:REACT_97634 "eEF1A complexes with GTP, Drosophila melanogaster" is_a: GO:0017076 ! purine nucleotide binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019002 name: GMP binding namespace: molecular_function def: "Interacting selectively and non-covalently with GMP, guanosine monophosphate." [GOC:ai] is_a: GO:0032550 ! purine ribonucleoside binding is_a: GO:0032561 ! guanyl ribonucleotide binding is_a: GO:0043168 ! anion binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019003 name: GDP binding namespace: molecular_function def: "Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate." [GOC:ai] is_a: GO:0032550 ! purine ribonucleoside binding is_a: GO:0032561 ! guanyl ribonucleotide binding is_a: GO:0043168 ! anion binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019104 name: DNA N-glycosylase activity namespace: molecular_function alt_id: GO:0008578 def: "Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:11554296] subset: gosubset_prok synonym: "DNA glycosylase activity" EXACT [] synonym: "endonuclease VIII activity" RELATED [] xref: EC:3.2.2.- xref: Reactome:REACT_100184 "Cleavage of ethenoadenine by MPG glycosylase, Sus scrofa" xref: Reactome:REACT_100211 "Cleavage of thymine by MBD4 glycosylase, Oryza sativa" xref: Reactome:REACT_100545 "Cleavage of 3-methyladenine by MPG glycosylase, Staphylococcus aureus N315" xref: Reactome:REACT_100572 "Cleavage of 3-methyladenine by MPG glycosylase, Bos taurus" xref: Reactome:REACT_100860 "Cleavage of thymine by TDG glycosylase, Danio rerio" xref: Reactome:REACT_101772 "Cleavage of thymine by TDG glycosylase, Xenopus tropicalis" xref: Reactome:REACT_101927 "Cleavage of uracil by MBD4 glycosylase, Xenopus tropicalis" xref: Reactome:REACT_102102 "Cleavage of ethenoadenine by MPG glycosylase, Bos taurus" xref: Reactome:REACT_102526 "TDG glycosylase mediated recognition and binding of an thymine opposite to a guanine, Escherichia coli" xref: Reactome:REACT_102669 "Cleavage of ethenocytosine by TDG glycosylase, Bos taurus" xref: Reactome:REACT_102750 "Cleavage of ethenoadenine by MPG glycosylase, Rattus norvegicus" xref: Reactome:REACT_103152 "Cleavage of hypoxanthine by MPG glycosylase, Mus musculus" xref: Reactome:REACT_103163 "Cleavage of ethenoadenine by MPG glycosylase, Xenopus tropicalis" xref: Reactome:REACT_103679 "Cleavage of ethenoadenine by MPG glycosylase, Mus musculus" xref: Reactome:REACT_104296 "Cleavage of thymine by MBD4 glycosylase, Bos taurus" xref: Reactome:REACT_104393 "Cleavage of thymine by TDG glycosylase, Schizosaccharomyces pombe" xref: Reactome:REACT_104604 "Cleavage of ethenocytosine by TDG glycosylase, Schizosaccharomyces pombe" xref: Reactome:REACT_104916 "Cleavage of thymine by MBD4 glycosylase, Taeniopygia guttata" xref: Reactome:REACT_105162 "Cleavage of ethenocytosine by TDG glycosylase, Danio rerio" xref: Reactome:REACT_105255 "Cleavage 8-oxo guanine by MYH glycosylase, Taeniopygia guttata" xref: Reactome:REACT_105536 "Cleavage of ethenocytosine by TDG glycosylase, Canis familiaris" xref: Reactome:REACT_106436 "Cleavage of 3-methyladenine by MPG glycosylase, Mycobacterium tuberculosis" xref: Reactome:REACT_106517 "Cleavage of 3-methyladenine by MPG glycosylase, Taeniopygia guttata" xref: Reactome:REACT_106727 "Cleavage of thymine by MBD4 glycosylase, Canis familiaris" xref: Reactome:REACT_107229 "Cleavage of uracil by MBD4 glycosylase, Taeniopygia guttata" xref: Reactome:REACT_107507 "Cleavage of thymine by MBD4 glycosylase, Rattus norvegicus" xref: Reactome:REACT_107862 "Cleavage of uracil by MBD4 glycosylase, Sus scrofa" xref: Reactome:REACT_108034 "Cleavage of 3-methyladenine by MPG glycosylase, Danio rerio" xref: Reactome:REACT_108184 "Cleavage of 3-methyladenine by MPG glycosylase, Plasmodium falciparum" xref: Reactome:REACT_108420 "Cleavage of 3-methyladenine by MPG glycosylase, Oryza sativa" xref: Reactome:REACT_108859 "Cleavage 8-oxo guanine by MYH glycosylase, Plasmodium falciparum" xref: Reactome:REACT_109496 "Cleavage 8-oxo guanine by MYH glycosylase, Arabidopsis thaliana" xref: Reactome:REACT_109568 "Cleavage 8-oxo guanine by MYH glycosylase, Schizosaccharomyces pombe" xref: Reactome:REACT_109794 "Cleavage 8-oxo guanine by MYH glycosylase, Canis familiaris" xref: Reactome:REACT_110244 "TDG glycosylase mediated recognition and binding of an thymine opposite to a guanine, Schizosaccharomyces pombe" xref: Reactome:REACT_110279 "Cleavage of uracil by MBD4 glycosylase, Oryza sativa" xref: Reactome:REACT_115660 "TDG glycosylase mediated recognition and binding of thymine opposite guanine, Gallus gallus" xref: Reactome:REACT_115848 "5-methylcytosine G/T mismatch specific DNA glycosylase mediated recognition and binding of thymine opposite guanine at CpG sequences, Gallus gallus" xref: Reactome:REACT_116111 "Cleavage of thymine by 5-methylcytosine G/T mismatch specific glycosylase, Gallus gallus" xref: Reactome:REACT_116119 "Cleavage of thymine by TDG glycosylase, Gallus gallus" xref: Reactome:REACT_1229 "Cleavage of ethenocytosine by TDG glycosylase, Homo sapiens" xref: Reactome:REACT_1600 "TDG glycosylase mediated recognition and binding of an thymine opposite to a guanine, Homo sapiens" xref: Reactome:REACT_28101 "Cleavage of hypoxanthine by MPG glycosylase, Gallus gallus" xref: Reactome:REACT_28159 "Cleavage of thymine by TDG glycosylase, Canis familiaris" xref: Reactome:REACT_28176 "Cleavage of ethenoadenine by MPG glycosylase, Danio rerio" xref: Reactome:REACT_28208 "TDG glycosylase mediated recognition and binding of an thymine opposite to a guanine, Drosophila melanogaster" xref: Reactome:REACT_28786 "Cleavage 8-oxo guanine by MYH glycosylase, Oryza sativa" xref: Reactome:REACT_29247 "Cleavage of thymine by TDG glycosylase, Rattus norvegicus" xref: Reactome:REACT_29392 "Cleavage of ethenocytosine by TDG glycosylase, Drosophila melanogaster" xref: Reactome:REACT_29546 "Cleavage of thymine by TDG glycosylase, Mus musculus" xref: Reactome:REACT_29690 "Cleavage of ethenocytosine by TDG glycosylase, Mus musculus" xref: Reactome:REACT_29777 "Cleavage of ethenocytosine by TDG glycosylase, Gallus gallus" xref: Reactome:REACT_30040 "Cleavage of hypoxanthine by MPG glycosylase, Bos taurus" xref: Reactome:REACT_303 "Cleavage of uracil by MBD4 glycosylase, Homo sapiens" xref: Reactome:REACT_30768 "Cleavage of thymine by MBD4 glycosylase, Sus scrofa" xref: Reactome:REACT_31100 "Cleavage 8-oxo guanine by MYH glycosylase, Xenopus tropicalis" xref: Reactome:REACT_32470 "Cleavage of ethenocytosine by TDG glycosylase, Escherichia coli" xref: Reactome:REACT_33120 "Cleavage of thymine by MBD4 glycosylase, Xenopus tropicalis" xref: Reactome:REACT_33202 "TDG glycosylase mediated recognition and binding of an thymine opposite to a guanine, Rattus norvegicus" xref: Reactome:REACT_33763 "Cleavage of uracil by MBD4 glycosylase, Gallus gallus" xref: Reactome:REACT_34055 "Cleavage of ethenocytosine by TDG glycosylase, Rattus norvegicus" xref: Reactome:REACT_34400 "Cleavage 8-oxo guanine by MYH glycosylase, Escherichia coli" xref: Reactome:REACT_34443 "Cleavage of thymine by MBD4 glycosylase, Gallus gallus" xref: Reactome:REACT_34733 "Cleavage of hypoxanthine by MPG glycosylase, Rattus norvegicus" xref: Reactome:REACT_492 "Cleavage of hypoxanthine by MPG glycosylase, Homo sapiens" xref: Reactome:REACT_77896 "Cleavage of uracil by MBD4 glycosylase, Arabidopsis thaliana" xref: Reactome:REACT_77932 "Cleavage of hypoxanthine by MPG glycosylase, Oryza sativa" xref: Reactome:REACT_78986 "Cleavage of thymine by MBD4 glycosylase, Arabidopsis thaliana" xref: Reactome:REACT_79292 "Cleavage 8-oxo guanine by MYH glycosylase, Sus scrofa" xref: Reactome:REACT_80125 "Cleavage of thymine by TDG glycosylase, Bos taurus" xref: Reactome:REACT_80550 "Cleavage of 3-methyladenine by MPG glycosylase, Mus musculus" xref: Reactome:REACT_80623 "TDG glycosylase mediated recognition and binding of an thymine opposite to a guanine, Taeniopygia guttata" xref: Reactome:REACT_81484 "Cleavage of uracil by MBD4 glycosylase, Mus musculus" xref: Reactome:REACT_81566 "Cleavage of 3-methyladenine by MPG glycosylase, Rattus norvegicus" xref: Reactome:REACT_81785 "Cleavage 8-oxo guanine by MYH glycosylase, Bos taurus" xref: Reactome:REACT_818 "Cleavage 8-oxo guanine by MYH glycosylase, Homo sapiens" xref: Reactome:REACT_81966 "Cleavage 8-oxo guanine by MYH glycosylase, Gallus gallus" xref: Reactome:REACT_82826 "Cleavage of 3-methyladenine by MPG glycosylase, Sus scrofa" xref: Reactome:REACT_82842 "Cleavage of hypoxanthine by MPG glycosylase, Arabidopsis thaliana" xref: Reactome:REACT_82858 "Cleavage of ethenoadenine by MPG glycosylase, Plasmodium falciparum" xref: Reactome:REACT_82984 "TDG glycosylase mediated recognition and binding of an thymine opposite to a guanine, Danio rerio" xref: Reactome:REACT_83090 "Cleavage of ethenoadenine by MPG glycosylase, Mycobacterium tuberculosis" xref: Reactome:REACT_83448 "Cleavage of ethenoadenine by MPG glycosylase, Oryza sativa" xref: Reactome:REACT_840 "Cleavage of thymine by MBD4 glycosylase, Homo sapiens" xref: Reactome:REACT_84320 "TDG glycosylase mediated recognition and binding of an thymine opposite to a guanine, Canis familiaris" xref: Reactome:REACT_84884 "Cleavage 8-oxo guanine by MYH glycosylase, Mus musculus" xref: Reactome:REACT_85353 "Cleavage of hypoxanthine by MPG glycosylase, Danio rerio" xref: Reactome:REACT_86036 "Cleavage of hypoxanthine by MPG glycosylase, Canis familiaris" xref: Reactome:REACT_86302 "Cleavage of hypoxanthine by MPG glycosylase, Mycobacterium tuberculosis" xref: Reactome:REACT_86538 "Cleavage of 3-methyladenine by MPG glycosylase, Canis familiaris" xref: Reactome:REACT_86544 "TDG glycosylase mediated recognition and binding of an thymine opposite to a guanine, Mus musculus" xref: Reactome:REACT_86715 "Cleavage of 3-methyladenine by MPG glycosylase, Gallus gallus" xref: Reactome:REACT_87262 "Cleavage of uracil by MBD4 glycosylase, Bos taurus" xref: Reactome:REACT_87430 "Cleavage of ethenoadenine by MPG glycosylase, Canis familiaris" xref: Reactome:REACT_88132 "Cleavage of hypoxanthine by MPG glycosylase, Taeniopygia guttata" xref: Reactome:REACT_88592 "TDG glycosylase mediated recognition and binding of an thymine opposite to a guanine, Bos taurus" xref: Reactome:REACT_89084 "Cleavage of ethenocytosine by TDG glycosylase, Taeniopygia guttata" xref: Reactome:REACT_89263 "Cleavage of thymine by MBD4 glycosylase, Mus musculus" xref: Reactome:REACT_89512 "Cleavage of ethenoadenine by MPG glycosylase, Staphylococcus aureus N315" xref: Reactome:REACT_90213 "Cleavage of ethenoadenine by MPG glycosylase, Arabidopsis thaliana" xref: Reactome:REACT_90264 "Cleavage of thymine by TDG glycosylase, Taeniopygia guttata" xref: Reactome:REACT_90642 "Cleavage of ethenocytosine by TDG glycosylase, Xenopus tropicalis" xref: Reactome:REACT_90755 "Cleavage of uracil by MBD4 glycosylase, Rattus norvegicus" xref: Reactome:REACT_909 "Cleavage of ethenoadenine by MPG glycosylase, Homo sapiens" xref: Reactome:REACT_91077 "Cleavage 8-oxo guanine by MYH glycosylase, Mycobacterium tuberculosis" xref: Reactome:REACT_91215 "TDG glycosylase mediated recognition and binding of an thymine opposite to a guanine, Xenopus tropicalis" xref: Reactome:REACT_91219 "Cleavage of uracil by MBD4 glycosylase, Canis familiaris" xref: Reactome:REACT_91653 "Cleavage of ethenoadenine by MPG glycosylase, Gallus gallus" xref: Reactome:REACT_92 "Cleavage of thymine by TDG glycosylase, Homo sapiens" xref: Reactome:REACT_924 "Cleavage of 3-methyladenine by MPG glycosylase, Homo sapiens" xref: Reactome:REACT_92760 "Cleavage of ethenoadenine by MPG glycosylase, Taeniopygia guttata" xref: Reactome:REACT_93435 "Cleavage of thymine by TDG glycosylase, Sus scrofa" xref: Reactome:REACT_94574 "Cleavage 8-oxo guanine by MYH glycosylase, Staphylococcus aureus N315" xref: Reactome:REACT_94831 "Cleavage of thymine by TDG glycosylase, Escherichia coli" xref: Reactome:REACT_94922 "Cleavage 8-oxo guanine by MYH glycosylase, Rattus norvegicus" xref: Reactome:REACT_95394 "Cleavage of ethenocytosine by TDG glycosylase, Sus scrofa" xref: Reactome:REACT_95577 "Cleavage of thymine by TDG glycosylase, Drosophila melanogaster" xref: Reactome:REACT_96015 "Cleavage 8-oxo guanine by MYH glycosylase, Dictyostelium discoideum" xref: Reactome:REACT_96296 "Cleavage of hypoxanthine by MPG glycosylase, Xenopus tropicalis" xref: Reactome:REACT_96301 "Cleavage of hypoxanthine by MPG glycosylase, Staphylococcus aureus N315" xref: Reactome:REACT_96358 "Cleavage of hypoxanthine by MPG glycosylase, Plasmodium falciparum" xref: Reactome:REACT_96363 "Cleavage of 3-methyladenine by MPG glycosylase, Xenopus tropicalis" xref: Reactome:REACT_96410 "Cleavage of hypoxanthine by MPG glycosylase, Sus scrofa" xref: Reactome:REACT_98134 "Cleavage of thymine by TDG glycosylase, Gallus gallus" xref: Reactome:REACT_98153 "TDG glycosylase mediated recognition and binding of an thymine opposite to a guanine, Sus scrofa" xref: Reactome:REACT_98446 "Cleavage 8-oxo guanine by MYH glycosylase, Danio rerio" xref: Reactome:REACT_98817 "TDG glycosylase mediated recognition and binding of an thymine opposite to a guanine, Gallus gallus" xref: Reactome:REACT_99235 "Cleavage of 3-methyladenine by MPG glycosylase, Arabidopsis thaliana" is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019172 name: glyoxalase III activity namespace: molecular_function def: "Catalysis of the reaction: methylglyoxal + H2O = D-lactate." [EC:4.2.1.130, GOC:mcc, http://www.brenda-enzymes.org/php/result_flat.php4?ecno=4.2.1.130, MetaCyc:GLYOXIII-RXN, PMID:21696459, PMID:7848303, RHEA:27757] comment: Note that this term was reinstated from obsolete. Also note that this enzymatic activity converts methylglyoxal to D-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalyzed by EC 4.4.1.5 (lactoylglutathione lyase) and EC 3.1.2.6 (hydroxyacylglutathione hydrolase). synonym: "(R)-lactate hydro-lyase" EXACT [] synonym: "D-lactate dehydratase" EXACT [] synonym: "glutathione-independent glyoxalase activity" RELATED [] xref: MetaCyc:GLYOXIII-RXN xref: RHEA:27754 is_a: GO:0016836 ! hydro-lyase activity relationship: part_of GO:0019249 ! lactate biosynthetic process relationship: part_of GO:0061727 ! methylglyoxal catabolic process to lactate property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019184 name: nonribosomal peptide biosynthetic process namespace: biological_process def: "The biosynthetic process in which peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione." [ISBN:0198506732] subset: gosubset_prok synonym: "non-ribosomal peptide biosynthesis" EXACT [] synonym: "non-ribosomal peptide biosynthetic process" EXACT [] synonym: "non-ribosomal peptide formation" EXACT [] synonym: "non-ribosomal peptide synthesis" EXACT [] synonym: "nonribosomal peptide anabolism" EXACT [] synonym: "nonribosomal peptide biosynthesis" EXACT [] synonym: "nonribosomal peptide formation" EXACT [] synonym: "nonribosomal peptide synthesis" EXACT [] synonym: "nonribosomal peptide synthetase" RELATED [] is_a: GO:0043043 ! peptide biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019201 name: nucleotide kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate." [GOC:ai, ISBN:0198506732] subset: gosubset_prok is_a: GO:0019205 ! nucleobase-containing compound kinase activity relationship: part_of GO:0046939 ! nucleotide phosphorylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019205 name: nucleobase-containing compound kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl] subset: gosubset_prok synonym: "nucleobase, nucleoside, nucleotide kinase activity" RELATED [GOC:dph, GOC:tb] is_a: GO:0016301 ! kinase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019213 name: deacetylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:jl] subset: goslim_pir subset: gosubset_prok is_a: GO:0016787 ! hydrolase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019219 name: regulation of nucleobase-containing compound metabolic process namespace: biological_process def: "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006139 ! nucleobase-containing compound metabolic process relationship: regulates GO:0006139 ! nucleobase-containing compound metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019220 name: regulation of phosphate metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of phosphate metabolism" EXACT [] is_a: GO:0051174 ! regulation of phosphorus metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006796 ! phosphate-containing compound metabolic process relationship: regulates GO:0006796 ! phosphate-containing compound metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019222 name: regulation of metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of metabolism" EXACT [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0008152 ! metabolic process relationship: regulates GO:0008152 ! metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019236 name: response to pheromone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:jl] subset: gosubset_prok synonym: "pheromone response" EXACT [] is_a: GO:0010033 ! response to organic substance property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019238 name: cyclohydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2, in a reaction that involves the opening of a ring." [GOC:mah] subset: gosubset_prok is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019249 name: lactate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lactate, the anion of lactic acid." [GOC:go_curators] subset: gosubset_prok synonym: "lactate anabolism" EXACT [] synonym: "lactate biosynthesis" EXACT [] synonym: "lactate formation" EXACT [] synonym: "lactate synthesis" EXACT [] is_a: GO:0006089 ! lactate metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019344 name: cysteine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "cysteine anabolism" EXACT [] synonym: "cysteine biosynthesis" EXACT [] synonym: "cysteine formation" EXACT [] synonym: "cysteine synthesis" EXACT [] is_a: GO:0000097 ! sulfur amino acid biosynthetic process is_a: GO:0006534 ! cysteine metabolic process is_a: GO:0009070 ! serine family amino acid biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019430 name: removal of superoxide radicals namespace: biological_process def: "Any process involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2)." [CHEBI:18421, GOC:jl] subset: gosubset_prok synonym: "removal of O2-" EXACT [] synonym: "removal of oxygen free radicals" EXACT [] xref: MetaCyc:DETOX1-PWY is_a: GO:0006801 ! superoxide metabolic process is_a: GO:0044710 ! single-organism metabolic process is_a: GO:0044763 ! single-organism cellular process relationship: part_of GO:0071451 ! cellular response to superoxide property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019432 name: triglyceride biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol." [ISBN:0198506732] subset: gosubset_prok synonym: "triacylglycerol biosynthesis" EXACT [] synonym: "triacylglycerol biosynthetic process" EXACT [] synonym: "triglyceride anabolism" EXACT [] synonym: "triglyceride biosynthesis" EXACT [] synonym: "triglyceride formation" EXACT [] synonym: "triglyceride synthesis" EXACT [] xref: MetaCyc:TRIGLSYN-PWY xref: Reactome:REACT_100326 "Triglyceride Biosynthesis, Mus musculus" xref: Reactome:REACT_102463 "Triglyceride Biosynthesis, Danio rerio" xref: Reactome:REACT_102566 "Triglyceride Biosynthesis, Taeniopygia guttata" xref: Reactome:REACT_104093 "Triglyceride Biosynthesis, Saccharomyces cerevisiae" xref: Reactome:REACT_106512 "Triglyceride Biosynthesis, Oryza sativa" xref: Reactome:REACT_107325 "Triglyceride Biosynthesis, Drosophila melanogaster" xref: Reactome:REACT_107784 "Triglyceride Biosynthesis, Dictyostelium discoideum" xref: Reactome:REACT_110365 "Triglyceride Biosynthesis, Arabidopsis thaliana" xref: Reactome:REACT_1190 "Triglyceride Biosynthesis, Homo sapiens" xref: Reactome:REACT_30474 "Triglyceride Biosynthesis, Mycobacterium tuberculosis" xref: Reactome:REACT_34309 "Triglyceride Biosynthesis, Sus scrofa" xref: Reactome:REACT_81292 "Triglyceride Biosynthesis, Xenopus tropicalis" xref: Reactome:REACT_81530 "Triglyceride Biosynthesis, Schizosaccharomyces pombe" xref: Reactome:REACT_82183 "Triglyceride Biosynthesis, Plasmodium falciparum" xref: Reactome:REACT_84161 "Triglyceride Biosynthesis, Bos taurus" xref: Reactome:REACT_91173 "Triglyceride Biosynthesis, Canis familiaris" xref: Reactome:REACT_93188 "Triglyceride Biosynthesis, Rattus norvegicus" xref: Reactome:REACT_95647 "Triglyceride Biosynthesis, Escherichia coli" xref: Reactome:REACT_96246 "Triglyceride Biosynthesis, Caenorhabditis elegans" xref: Reactome:REACT_99272 "Triglyceride Biosynthesis, Gallus gallus" is_a: GO:0006641 ! triglyceride metabolic process is_a: GO:0046463 ! acylglycerol biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019438 name: aromatic compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai] subset: gosubset_prok synonym: "aromatic compound anabolism" EXACT [] synonym: "aromatic compound biosynthesis" EXACT [] synonym: "aromatic compound formation" EXACT [] synonym: "aromatic compound synthesis" EXACT [] synonym: "aromatic hydrocarbon biosynthesis" NARROW [] synonym: "aromatic hydrocarbon biosynthetic process" NARROW [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0044249 ! cellular biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019439 name: aromatic compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai] subset: gosubset_prok synonym: "aromatic compound breakdown" EXACT [] synonym: "aromatic compound catabolism" EXACT [] synonym: "aromatic compound degradation" EXACT [] synonym: "aromatic hydrocarbon catabolic process" NARROW [] synonym: "aromatic hydrocarbon catabolism" NARROW [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0044248 ! cellular catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019493 name: arginine catabolic process to proline namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including proline." [GOC:go_curators] subset: gosubset_prok synonym: "arginine breakdown to proline" EXACT [] synonym: "arginine degradation to proline" EXACT [] xref: MetaCyc:ARG-PRO-PWY is_a: GO:0006527 ! arginine catabolic process is_a: GO:0006560 ! proline metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019538 name: protein metabolic process namespace: biological_process alt_id: GO:0006411 def: "The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification." [GOC:ma] subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "protein metabolic process and modification" EXACT [] synonym: "protein metabolism" EXACT [] synonym: "protein metabolism and modification" EXACT [] xref: Wikipedia:Protein_metabolism is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:0044238 ! primary metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019637 name: organophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound." [ISBN:0198506732] subset: gosubset_prok synonym: "organophosphate metabolism" EXACT [] is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0071704 ! organic substance metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019692 name: deoxyribose phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [ISBN:0198506732] subset: gosubset_prok synonym: "deoxyribose phosphate metabolism" EXACT [] is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019693 name: ribose phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar." [GOC:ai] subset: gosubset_prok synonym: "ribose phosphate metabolism" EXACT [] is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019725 name: cellular homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state at the level of the cell." [GOC:isa_complete, GOC:jl, ISBN:0395825172] subset: goslim_aspergillus subset: goslim_candida subset: goslim_plant subset: gosubset_prok is_a: GO:0042592 ! homeostatic process is_a: GO:0044763 ! single-organism cellular process intersection_of: GO:0042592 ! homeostatic process intersection_of: occurs_in GO:0005623 ! cell relationship: occurs_in GO:0005623 ! cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019752 name: carboxylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732] subset: gosubset_prok synonym: "carboxylic acid metabolism" EXACT [] is_a: GO:0043436 ! oxoacid metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019787 name: ubiquitin-like protein transferase activity namespace: molecular_function alt_id: GO:0008639 alt_id: GO:0008640 def: "Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y --> Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein." [GOC:mah, GOC:rn, PMID:10806345, PMID:10884686] subset: gosubset_prok synonym: "E2" RELATED [] synonym: "E3" RELATED [dph:GOC] synonym: "small conjugating protein ligase activity" NARROW [GOC:dph] synonym: "small conjugating protein transferase activity" EXACT [GOC:dph] synonym: "small protein conjugating enzyme activity" NARROW [] synonym: "ubiquitin-like conjugating enzyme activity" NARROW [] synonym: "ubiquitin-like-protein ligase activity" NARROW [] xref: Reactome:REACT_75843 "RIP2 is K63 polyubiquitinated, Homo sapiens" is_a: GO:0016740 ! transferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019829 name: cation-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai] subset: gosubset_prok synonym: "cation ABC transporter" NARROW [] synonym: "plasma membrane cation-transporting ATPase" NARROW [] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0042625 ! ATPase activity, coupled to transmembrane movement of ions property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019835 name: cytolysis namespace: biological_process def: "The rupture of cell membranes and the loss of cytoplasm." [UniProtKB-KW:KW-0204] subset: goslim_chembl subset: gosubset_prok synonym: "autolysin activity" RELATED [] synonym: "bacteriocin activity" RELATED [] synonym: "bacteriolytic toxin activity" RELATED [] synonym: "holin" RELATED [] synonym: "lysin activity" RELATED [] synonym: "lysis" BROAD [] synonym: "necrosis" RELATED [] xref: Wikipedia:Cytolysis is_a: GO:0009987 ! cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019866 name: organelle inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites." [GOC:mah] comment: See also the cellular component term 'outer membrane ; GO:0019867'. subset: gosubset_prok is_a: GO:0031090 ! organelle membrane is_a: GO:0044424 ! intracellular part relationship: part_of GO:0031967 ! organelle envelope property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019899 name: enzyme binding namespace: molecular_function def: "Interacting selectively and non-covalently with any enzyme." [GOC:jl] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast subset: gosubset_prok is_a: GO:0005515 ! protein binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019941 name: modification-dependent protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators] subset: gosubset_prok synonym: "modification-dependent protein breakdown" EXACT [] synonym: "modification-dependent protein catabolism" EXACT [] synonym: "modification-dependent protein degradation" EXACT [] synonym: "modification-dependent proteolysis" EXACT [GOC:rl] synonym: "modification-initiated protein catabolic process" EXACT [GOC:rl] synonym: "modification-initiated protein catabolism" EXACT [GOC:rl] synonym: "modification-initiated proteolysis" EXACT [GOC:rl] synonym: "protein degradation tagging activity" RELATED [] synonym: "protein-ligand-dependent protein catabolic process" NARROW [] synonym: "protein-ligand-dependent protein catabolism" NARROW [] is_a: GO:0043632 ! modification-dependent macromolecule catabolic process is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019953 name: sexual reproduction namespace: biological_process def: "A reproduction process that creates a new organism by combining the genetic material of two organisms. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two different individuals (parents) join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny." [GOC:jl, http://en.wikipedia.org/wiki/Sexual_reproduction, ISBN:0387520546] comment: Sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. xref: Wikipedia:Sexual_reproduction is_a: GO:0000003 ! reproduction is_a: GO:0044703 ! multi-organism reproductive process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0019985 name: translesion synthesis namespace: biological_process def: "The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide." [GOC:elh, PMID:10535901] subset: gosubset_prok synonym: "bypass DNA synthesis" EXACT [GOC:elh] xref: Reactome:REACT_115598 "DNA damage bypass, Gallus gallus" xref: Reactome:REACT_115640 "Translesion synthesis by Pol kappa, Gallus gallus" xref: Reactome:REACT_115864 "Translesion synthesis by Pol eta, Gallus gallus" xref: Reactome:REACT_115941 "Translesion synthesis by DNA polymerases bypassing lesion on DNA template, Gallus gallus" xref: Reactome:REACT_116049 "RAD18 and ubiquitinated PCNA-mediated recruitment of translesion polymerases, Gallus gallus" xref: Reactome:REACT_116052 "Translesion synthesis by Pol zeta, Gallus gallus" is_a: GO:0006301 ! postreplication repair is_a: GO:0044711 ! single-organism biosynthetic process is_a: GO:0071897 ! DNA biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0020037 name: heme binding namespace: molecular_function def: "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] subset: gosubset_prok synonym: "haem binding" EXACT [] is_a: GO:0046906 ! tetrapyrrole binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0022402 name: cell cycle process namespace: biological_process def: "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] subset: gocheck_do_not_manually_annotate subset: gosubset_prok is_a: GO:0044763 ! single-organism cellular process intersection_of: GO:0009987 ! cellular process intersection_of: part_of GO:0007049 ! cell cycle relationship: part_of GO:0007049 ! cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0022403 name: cell cycle phase namespace: biological_process def: "One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GOC:mtg_cell_cycle] subset: gocheck_do_not_annotate is_a: GO:0044848 ! biological phase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0022406 name: membrane docking namespace: biological_process def: "The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:isa_complete] subset: goslim_pir is_a: GO:0044763 ! single-organism cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0022411 name: cellular component disassembly namespace: biological_process alt_id: GO:0071845 def: "A cellular process that results in the breakdown of a cellular component." [GOC:isa_complete] subset: goslim_pir subset: gosubset_prok synonym: "cell structure disassembly" EXACT [] synonym: "cellular component disassembly at cellular level" EXACT [] is_a: GO:0016043 ! cellular component organization is_a: GO:0044763 ! single-organism cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0022413 name: reproductive process in single-celled organism namespace: biological_process def: "A process, occurring at the cellular level, that is involved in the reproductive function of a single-celled organism." [GOC:isa_complete] subset: gosubset_prok is_a: GO:0022414 ! reproductive process relationship: part_of GO:0032505 ! reproduction of a single-celled organism property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0022414 name: reproductive process namespace: biological_process def: "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete] subset: gosubset_prok is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0022603 name: regulation of anatomical structure morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis." [GOC:mah] subset: gosubset_prok synonym: "regulation of morphogenesis" EXACT [] is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009653 ! anatomical structure morphogenesis relationship: regulates GO:0009653 ! anatomical structure morphogenesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0022604 name: regulation of cell morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized." [GOC:isa_complete] subset: gosubset_prok synonym: "negative regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb] synonym: "regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0000902 ! cell morphogenesis relationship: regulates GO:0000902 ! cell morphogenesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0022607 name: cellular component assembly namespace: biological_process alt_id: GO:0071844 def: "The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: gosubset_prok synonym: "cell structure assembly" EXACT [] synonym: "cellular component assembly at cellular level" EXACT [] is_a: GO:0016043 ! cellular component organization relationship: part_of GO:0044085 ! cellular component biogenesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0022610 name: biological adhesion namespace: biological_process def: "The attachment of a cell or organism to a substrate or other organism." [GOC:isa_complete] subset: goslim_pir subset: gosubset_prok is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0022613 name: ribonucleoprotein complex biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex." [GOC:isa_complete, GOC:mah] subset: gosubset_prok synonym: "ribonucleoprotein complex biogenesis and assembly" EXACT [GOC:mah] synonym: "RNA-protein complex biogenesis" EXACT [GOC:mah] is_a: GO:0044085 ! cellular component biogenesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0022616 name: DNA strand elongation namespace: biological_process def: "The DNA metabolic process in which a DNA strand is synthesized by adding nucleotides to the 3' end of an existing DNA stand." [GOC:isa_complete] is_a: GO:0006259 ! DNA metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0022618 name: ribonucleoprotein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl] subset: goslim_chembl subset: goslim_generic subset: gosubset_prok synonym: "protein-RNA complex assembly" EXACT [] synonym: "RNA-protein complex assembly" EXACT [] synonym: "RNP complex assembly" EXACT [] is_a: GO:0034622 ! cellular macromolecular complex assembly is_a: GO:0071826 ! ribonucleoprotein complex subunit organization relationship: part_of GO:0022613 ! ribonucleoprotein complex biogenesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0022625 name: cytosolic large ribosomal subunit namespace: cellular_component alt_id: GO:0005842 alt_id: GO:0009282 alt_id: GO:0030498 alt_id: GO:0030872 def: "The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu] synonym: "50S ribosomal subunit" NARROW [] synonym: "60S ribosomal subunit" NARROW [] synonym: "eukaryotic ribosomal LSU" NARROW [] synonym: "prokaryotic large ribosomal subunit" NARROW [] is_a: GO:0015934 ! large ribosomal subunit is_a: GO:0044445 ! cytosolic part intersection_of: GO:0015934 ! large ribosomal subunit intersection_of: part_of GO:0022626 ! cytosolic ribosome relationship: part_of GO:0022626 ! cytosolic ribosome property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0022626 name: cytosolic ribosome namespace: cellular_component alt_id: GO:0005830 alt_id: GO:0009281 alt_id: GO:0030871 def: "A ribosome located in the cytosol." [GOC:mtg_sensu] synonym: "70S ribosome" NARROW [] synonym: "80S ribosome" NARROW [] is_a: GO:0005840 ! ribosome is_a: GO:0044445 ! cytosolic part intersection_of: GO:0005840 ! ribosome intersection_of: part_of GO:0005829 ! cytosol relationship: part_of GO:0005829 ! cytosol property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0022627 name: cytosolic small ribosomal subunit namespace: cellular_component alt_id: GO:0005843 alt_id: GO:0009283 alt_id: GO:0030499 alt_id: GO:0030873 def: "The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu] synonym: "30S ribosomal subunit" NARROW [] synonym: "40S ribosomal subunit" NARROW [] synonym: "eukaryotic ribosomal SSU" NARROW [] synonym: "prokaryotic small ribosomal subunit" NARROW [] is_a: GO:0015935 ! small ribosomal subunit is_a: GO:0044445 ! cytosolic part intersection_of: GO:0015935 ! small ribosomal subunit intersection_of: part_of GO:0022626 ! cytosolic ribosome relationship: part_of GO:0022626 ! cytosolic ribosome property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0022804 name: active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "active carrier activity" EXACT [] synonym: "carrier activity" EXACT [] synonym: "permease activity" EXACT [] synonym: "pump activity" EXACT [] is_a: GO:0022857 ! transmembrane transporter activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0022857 name: transmembrane transporter activity namespace: molecular_function alt_id: GO:0005386 alt_id: GO:0015646 def: "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast subset: gosubset_prok xref: Reactome:REACT_100033 "GLUT9 transports glucose, fructose and urate, Gallus gallus" xref: Reactome:REACT_106735 "GLUT9 transports glucose, fructose and urate, Xenopus tropicalis" xref: Reactome:REACT_111088 "Egress of internalized antigen to the cytosol via sec61, Homo sapiens" xref: Reactome:REACT_111933 "GLUT9 transports glucose, fructose and urate, Plasmodium falciparum" xref: Reactome:REACT_113047 "GLUT9 transports glucose, fructose and urate, Dictyostelium discoideum" xref: Reactome:REACT_113116 "GLUT9 transports glucose, fructose and urate, Mycobacterium tuberculosis" xref: Reactome:REACT_113829 "GLUT9 transports glucose, fructose and urate, Arabidopsis thaliana" xref: Reactome:REACT_114161 "GLUT9 transports glucose, fructose and urate, Oryza sativa" xref: Reactome:REACT_19288 "GLUT9 transports glucose, fructose and urate, Homo sapiens" xref: Reactome:REACT_77235 "GLUT9 transports glucose, fructose and urate, Canis familiaris" xref: Reactome:REACT_81225 "GLUT9 transports glucose, fructose and urate, Bos taurus" xref: Reactome:REACT_88503 "GLUT9 transports glucose, fructose and urate, Taeniopygia guttata" xref: Reactome:REACT_91849 "GLUT9 transports glucose, fructose and urate, Mus musculus" xref: Reactome:REACT_94185 "GLUT9 transports glucose, fructose and urate, Rattus norvegicus" is_a: GO:0005215 ! transporter activity relationship: part_of GO:0055085 ! transmembrane transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0022890 name: inorganic cation transmembrane transporter activity namespace: molecular_function alt_id: GO:0015082 def: "Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "di-, tri-valent inorganic cation transmembrane transporter activity" NARROW [GOC:mah] is_a: GO:0008324 ! cation transmembrane transporter activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0022891 name: substrate-specific transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok is_a: GO:0022857 ! transmembrane transporter activity is_a: GO:0022892 ! substrate-specific transporter activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0022892 name: substrate-specific transporter activity namespace: molecular_function def: "Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:mtg_transport] subset: gosubset_prok is_a: GO:0005215 ! transporter activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0022900 name: electron transport chain namespace: biological_process def: "A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport] subset: goslim_metagenomics subset: gosubset_prok xref: Wikipedia:Electron_transport_chain is_a: GO:0006091 ! generation of precursor metabolites and energy is_a: GO:0044763 ! single-organism cellular process is_a: GO:0055114 ! oxidation-reduction process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0022904 name: respiratory electron transport chain namespace: biological_process def: "A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0716720094] subset: gosubset_prok synonym: "6-phosphofructokinase reduction" RELATED [] synonym: "dihydrobiopterin reduction" RELATED [] synonym: "dihydrolipoamide reduction" RELATED [] synonym: "dihydrolipoylprotein reduction" RELATED [] synonym: "dihydropteridine reduction" RELATED [] synonym: "electron transfer" EXACT [] synonym: "other pathways of electron transport" RELATED [] synonym: "oxidized glutathione reduction" RELATED [] synonym: "protein-disulfide reduction" RELATED [] xref: Reactome:REACT_100934 "Respiratory electron transport, Rattus norvegicus" xref: Reactome:REACT_101166 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Drosophila melanogaster" xref: Reactome:REACT_103686 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Xenopus tropicalis" xref: Reactome:REACT_104669 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Sus scrofa" xref: Reactome:REACT_105063 "Respiratory electron transport, Danio rerio" xref: Reactome:REACT_107634 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Caenorhabditis elegans" xref: Reactome:REACT_108981 "Respiratory electron transport, Caenorhabditis elegans" xref: Reactome:REACT_109327 "Respiratory electron transport, Arabidopsis thaliana" xref: Reactome:REACT_110006 "Respiratory electron transport, Oryza sativa" xref: Reactome:REACT_110577 "Respiratory electron transport, Canis familiaris" xref: Reactome:REACT_22393 "Respiratory electron transport, Homo sapiens" xref: Reactome:REACT_28852 "Respiratory electron transport, Bos taurus" xref: Reactome:REACT_30009 "Respiratory electron transport, Sus scrofa" xref: Reactome:REACT_30834 "Respiratory electron transport, Drosophila melanogaster" xref: Reactome:REACT_31609 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Saccharomyces cerevisiae" xref: Reactome:REACT_33328 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Taeniopygia guttata" xref: Reactome:REACT_33999 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Bos taurus" xref: Reactome:REACT_38628 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Schizosaccharomyces pombe" xref: Reactome:REACT_6305 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Homo sapiens" xref: Reactome:REACT_78440 "Respiratory electron transport, Dictyostelium discoideum" xref: Reactome:REACT_79453 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Escherichia coli" xref: Reactome:REACT_81477 "Respiratory electron transport, Mus musculus" xref: Reactome:REACT_82198 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Gallus gallus" xref: Reactome:REACT_82340 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Oryza sativa" xref: Reactome:REACT_84453 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Arabidopsis thaliana" xref: Reactome:REACT_84989 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Rattus norvegicus" xref: Reactome:REACT_85095 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Mus musculus" xref: Reactome:REACT_86505 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Canis familiaris" xref: Reactome:REACT_86624 "Respiratory electron transport, Saccharomyces cerevisiae" xref: Reactome:REACT_87707 "Respiratory electron transport, Schizosaccharomyces pombe" xref: Reactome:REACT_88908 "Respiratory electron transport, Taeniopygia guttata" xref: Reactome:REACT_89723 "Respiratory electron transport, Xenopus tropicalis" xref: Reactome:REACT_89835 "Respiratory electron transport, Escherichia coli" xref: Reactome:REACT_92603 "Respiratory electron transport, Gallus gallus" xref: Reactome:REACT_93495 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Mycobacterium tuberculosis" xref: Reactome:REACT_93647 "Respiratory electron transport, Mycobacterium tuberculosis" xref: Reactome:REACT_96847 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Dictyostelium discoideum" xref: Reactome:REACT_99140 "Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins., Danio rerio" xref: Wikipedia:Electron_transfer is_a: GO:0022900 ! electron transport chain relationship: part_of GO:0045333 ! cellular respiration property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0023014 name: signal transduction by protein phosphorylation namespace: biological_process def: "A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate." [GOC:mtg_signal, GOC:signaling] synonym: "signal transduction via phosphorylation event" RELATED [GOC:bf] synonym: "signal transmission via phosphorylation event" RELATED [GOC:bf] is_a: GO:0006468 ! protein phosphorylation is_a: GO:0007165 ! signal transduction is_a: GO:0044710 ! single-organism metabolic process is_a: GO:0044763 ! single-organism cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023051 name: regulation of signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal] synonym: "regulation of signaling process" RELATED [GOC:bf] synonym: "regulation of signalling process" RELATED [GOC:mah] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0023052 ! signaling relationship: regulates GO:0023052 ! signaling property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023052 name: signaling namespace: biological_process alt_id: GO:0023046 def: "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling] comment: Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change. subset: goslim_pombe subset: goslim_yeast synonym: "biological signaling" EXACT [] synonym: "signaling process" EXACT [] synonym: "signalling" EXACT [] synonym: "signalling process" RELATED [GOC:mah] is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0023058 name: adaptation of signaling pathway namespace: biological_process def: "The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus." [GOC:mtg_signal] synonym: "adaptation of signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl creation_date: 2010-02-16T09:30:50Z [Term] id: GO:0030001 name: metal ion transport namespace: biological_process def: "The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "heavy metal ion transport" NARROW [] is_a: GO:0006812 ! cation transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030029 name: actin filament-based process namespace: biological_process def: "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah] synonym: "microfilament-based process" RELATED [] is_a: GO:0044763 ! single-organism cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030030 name: cell projection organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/] subset: gosubset_prok synonym: "cell projection organisation" EXACT [GOC:curators] synonym: "cell projection organization and biogenesis" RELATED [GOC:mah] synonym: "cell surface structure organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016043 ! cellular component organization is_a: GO:0044763 ! single-organism cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030031 name: cell projection assembly namespace: biological_process def: "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/] subset: goslim_metagenomics subset: gosubset_prok synonym: "cell projection biogenesis" RELATED [GOC:mah] synonym: "formation of a cell surface projection" EXACT [] is_a: GO:0022607 ! cellular component assembly is_a: GO:0030030 ! cell projection organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030036 name: actin cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] synonym: "actin cytoskeleton organisation" EXACT [GOC:curators] synonym: "actin cytoskeleton organization and biogenesis" RELATED [GOC:mah] synonym: "actin modulating activity" RELATED [] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0030029 ! actin filament-based process is_a: GO:1902589 ! single-organism organelle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030041 name: actin filament polymerization namespace: biological_process def: "Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] synonym: "actin polymerization" EXACT [] synonym: "actin polymerizing activity" RELATED [] is_a: GO:0008154 ! actin polymerization or depolymerization is_a: GO:0051258 ! protein polymerization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030048 name: actin filament-based movement namespace: biological_process def: "Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah] is_a: GO:0006928 ! movement of cell or subcellular component is_a: GO:0030029 ! actin filament-based process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030071 name: regulation of mitotic metaphase/anaphase transition namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the onset of anaphase (chromosome movement) in the mitotic cell cycle." [GOC:mah] is_a: GO:0007088 ! regulation of mitotic nuclear division is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition is_a: GO:1902099 ! regulation of metaphase/anaphase transition of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007091 ! metaphase/anaphase transition of mitotic cell cycle relationship: regulates GO:0007091 ! metaphase/anaphase transition of mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030133 name: transport vesicle namespace: cellular_component def: "Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell." [GOC:mah, PMID:22160157] comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'secretory granule ; GO:0030141'. synonym: "constitutive secretory pathway transport vesicle" EXACT [] synonym: "Golgi to vacuole transport vesicle" NARROW [] synonym: "Golgi-vacuole transport vesicle" NARROW [] synonym: "secretory vesicle" BROAD [] xref: NIF_Subcellular:sao885490876 is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle relationship: part_of GO:0012505 ! endomembrane system property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030154 name: cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] subset: goslim_chembl subset: goslim_generic subset: goslim_plant subset: gosubset_prok xref: Wikipedia:Cellular_differentiation is_a: GO:0048869 ! cellular developmental process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030162 name: regulation of proteolysis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah] subset: gosubset_prok synonym: "regulation of peptidolysis" EXACT [] is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006508 ! proteolysis relationship: regulates GO:0006508 ! proteolysis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030163 name: protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] comment: This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children. subset: goslim_aspergillus subset: goslim_candida subset: goslim_pombe subset: gosubset_prok synonym: "pheromone catabolic process" RELATED [] synonym: "pheromone catabolism" RELATED [] synonym: "protein breakdown" EXACT [] synonym: "protein catabolism" EXACT [] synonym: "protein degradation" EXACT [] xref: Wikipedia:Protein_catabolism is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0019538 ! protein metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030174 name: regulation of DNA-dependent DNA replication initiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase." [GOC:mah] subset: gosubset_prok synonym: "DNA replication licencing" EXACT [] synonym: "DNA replication licensing" EXACT [] synonym: "regulation of DNA replication initiation" BROAD [GOC:vw] is_a: GO:0090329 ! regulation of DNA-dependent DNA replication intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006270 ! DNA replication initiation relationship: regulates GO:0006270 ! DNA replication initiation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030234 name: enzyme regulator activity namespace: molecular_function def: "Binds to and modulates the activity of an enzyme." [GOC:mah] comment: GO:0030234 is reserved for cases when the regulator directly interacts with the enzyme. When regulation of enzyme activity is achieved without enzyme binding, or when the mechanism of regulation is unknown, instead annotate to 'regulation of catalytic activity ; GO:0050790'. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "catalytic regulator activity" EXACT [GOC:dph] synonym: "enzyme modulator" EXACT [] is_a: GO:0098772 ! molecular function regulator relationship: has_part GO:0019899 ! enzyme binding relationship: part_of GO:0050790 ! regulation of catalytic activity relationship: regulates GO:0003824 ! catalytic activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030242 name: pexophagy namespace: biological_process def: "The process in which peroxisomes are delivered to the vacuole and degraded in response to changing nutrient conditions." [GOC:autophagy, PMID:10547367, PMID:20083110] synonym: "peroxisome degradation" BROAD [] is_a: GO:0007031 ! peroxisome organization is_a: GO:0016236 ! macroautophagy is_a: GO:1902589 ! single-organism organelle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030246 name: carbohydrate binding namespace: molecular_function alt_id: GO:0005529 def: "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] subset: goslim_chembl subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "selectin" RELATED [] synonym: "sugar binding" EXACT [] is_a: GO:0005488 ! binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030261 name: chromosome condensation namespace: biological_process alt_id: GO:0000068 def: "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194] synonym: "DNA condensation" BROAD [Wikipedia:DNA_condensation] synonym: "eukaryotic chromosome condensation" EXACT [GOC:bf] synonym: "nuclear chromosome condensation" EXACT [GOC:bf] is_a: GO:0006323 ! DNA packaging is_a: GO:1902589 ! single-organism organelle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030307 name: positive regulation of cell growth namespace: biological_process def: "Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators] subset: gosubset_prok synonym: "activation of cell growth" NARROW [] synonym: "stimulation of cell growth" NARROW [] synonym: "up regulation of cell growth" EXACT [] synonym: "up-regulation of cell growth" EXACT [] synonym: "upregulation of cell growth" EXACT [] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0045927 ! positive regulation of growth is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0016049 ! cell growth relationship: positively_regulates GO:0016049 ! cell growth property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030312 name: external encapsulating structure namespace: cellular_component def: "A structure that lies outside the plasma membrane and surrounds the entire cell." [GOC:go_curators] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: gosubset_prok is_a: GO:0044464 ! cell part relationship: part_of GO:0071944 ! cell periphery property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030332 name: cyclin binding namespace: molecular_function def: "Interacting selectively and non-covalently with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis." [GOC:ai] is_a: GO:0005515 ! protein binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030337 name: DNA polymerase processivity factor activity namespace: molecular_function def: "An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it." [GOC:mah, PMID:7903401, PMID:8087839] subset: gosubset_prok synonym: "processivity clamp" EXACT [] synonym: "sliding clamp" EXACT [] is_a: GO:0030234 ! enzyme regulator activity relationship: part_of GO:0006259 ! DNA metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030427 name: site of polarized growth namespace: cellular_component alt_id: GO:0000134 alt_id: GO:0030483 def: "Any part of a cell where non-isotropic growth takes place." [GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_pir subset: goslim_yeast is_a: GO:0044464 ! cell part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030428 name: cell septum namespace: cellular_component def: "A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." [GOC:clt, ISBN:0471940526] subset: goslim_pir subset: gosubset_prok synonym: "cross wall" EXACT [] synonym: "septum" BROAD [] is_a: GO:0044464 ! cell part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030435 name: sporulation resulting in formation of a cellular spore namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:mah, GOC:pamgo_curators, ISBN:0072992913] comment: Note that the synonym 'spore differentiation', like the term name and definition, refers to differentiation into a spore rather than any subsequent developmental changes that a spore may undergo. subset: gosubset_prok synonym: "cellular spore formation by sporulation" EXACT [GOC:dph, GOC:tb] synonym: "spore biosynthesis" EXACT [] synonym: "spore differentiation" EXACT [] synonym: "spore formation" EXACT [] xref: Wikipedia:Sporogenesis is_a: GO:0030154 ! cell differentiation is_a: GO:0043934 ! sporulation is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030437 name: ascospore formation namespace: biological_process alt_id: GO:0007151 def: "The process in which cells that are products of meiosis acquire the specialized features of ascospores. Ascospores are generally found in clusters of four or eight spores within a single mother cell, the ascus, and are characteristic of the ascomycete fungi (phylum Ascomycota)." [GOC:di, GOC:mah, GOC:mcc, PMID:16339736] comment: Note that ascospores and asci are separate biological structures. The ascus is the structure that contain the ascospores, but the development of the ascus is a different process than the formation of the ascospores themselves; for instance, some mutations affect sporulation without affecting ascus development. For this reason, GO:0030437 ascospore formation and GO:0075317 ascus development are different terms and are not linked. subset: goslim_pombe synonym: "ascospore biosynthesis" EXACT [] synonym: "spore formation" BROAD [] synonym: "sporulation" BROAD [] is_a: GO:0022413 ! reproductive process in single-celled organism is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore is_a: GO:0048468 ! cell development property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030447 name: filamentous growth namespace: biological_process def: "The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:mcc, PMID:11729141] subset: goslim_aspergillus subset: goslim_candida is_a: GO:0040007 ! growth is_a: GO:0044699 ! single-organism process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030466 name: chromatin silencing at silent mating-type cassette namespace: biological_process alt_id: GO:0006347 def: "Repression of transcription at silent mating-type loci by alteration of the structure of chromatin." [GOC:mcc] synonym: "aging-dependent sterility" NARROW [] synonym: "chromatin silencing at HML and HMR" NARROW [] synonym: "heterochromatic silencing at silent mating-type cassette" EXACT [] synonym: "silent mating-type cassette chromatin silencing" EXACT [GOC:mah] is_a: GO:0006342 ! chromatin silencing property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030473 name: nuclear migration along microtubule namespace: biological_process alt_id: GO:0000065 def: "The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins." [GOC:mah, GOC:sgd_curators] synonym: "microtubule cytoskeleton-dependent nuclear positioning" EXACT [] synonym: "microtubule cytoskeleton-dependent nucleus positioning" EXACT [] synonym: "microtubule-dependent nuclear positioning" EXACT [] synonym: "microtubule-dependent nucleus positioning" EXACT [] synonym: "microtubule-mediated nuclear migration" EXACT [] synonym: "nuclear migration, microtubule-mediated" EXACT [] synonym: "nuclear movement, microtubule-mediated" BROAD [] synonym: "nucleus migration" BROAD [] synonym: "transport of nucleus by microtubules" EXACT [] synonym: "transport of nucleus, microtubule-mediated" EXACT [] is_a: GO:0007097 ! nuclear migration is_a: GO:0072384 ! organelle transport along microtubule is_a: GO:1902580 ! single-organism cellular localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030474 name: spindle pole body duplication namespace: biological_process alt_id: GO:0007103 alt_id: GO:0031046 def: "Construction of a new spindle pole body." [GOC:clt] synonym: "spindle pole body assembly" EXACT [] synonym: "spindle pole body biogenesis" EXACT [] synonym: "spindle pole body biosynthesis" EXACT [] synonym: "spindle pole body duplication associated with nuclear envelope" EXACT [] synonym: "spindle pole body duplication in cytoplasm" EXACT [] synonym: "spindle pole body formation" EXACT [] synonym: "spindle pole body replication" EXACT [] is_a: GO:0006461 ! protein complex assembly is_a: GO:0051300 ! spindle pole body organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030476 name: ascospore wall assembly namespace: biological_process alt_id: GO:0007152 def: "The aggregation, arrangement and bonding together of a set of components to form an ascospore wall. During sporulation in Ascomycota, each ascospore nucleus becomes surrounded by a specialized spore wall, formed by deposition of spore wall components in the lumenal space between the outer and inner leaflets of the prospore membrane. An example of this process is found in Saccharomyces cerevisiae." [GOC:mcc, PMID:14702385] synonym: "spore wall assembly" BROAD [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0042244 ! spore wall assembly is_a: GO:0044702 ! single organism reproductive process is_a: GO:0071940 ! fungal-type cell wall assembly is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0070591 ! ascospore wall biogenesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030479 name: actin cortical patch namespace: cellular_component alt_id: GO:0005857 def: "An endocytic patch that consists of an actin-containing structure found at the plasma membrane in cells; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae." [GOC:mah, GOC:vw, ISBN:0879693568, ISBN:0879693649, PMID:16959963] synonym: "actin patch" EXACT [] is_a: GO:0044430 ! cytoskeletal part is_a: GO:0061645 ! endocytic patch relationship: part_of GO:0030864 ! cortical actin cytoskeleton property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030488 name: tRNA methylation namespace: biological_process def: "The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule." [GOC:mah] subset: gosubset_prok is_a: GO:0001510 ! RNA methylation is_a: GO:0006400 ! tRNA modification property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030529 name: ribonucleoprotein complex namespace: cellular_component def: "A macromolecular complex containing both protein and RNA molecules." [GOC:krc] subset: goslim_pir subset: gosubset_prok synonym: "protein-RNA complex" EXACT [] synonym: "ribonucleoprotein" EXACT [] synonym: "RNA-protein complex" EXACT [] synonym: "RNP" EXACT [] xref: Wikipedia:Ribonucleoprotein is_a: GO:0032991 ! macromolecular complex is_a: GO:0044424 ! intracellular part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030532 name: small nuclear ribonucleoprotein complex namespace: cellular_component def: "A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897] subset: goslim_pir synonym: "small nuclear ribonucleoprotein" EXACT [] synonym: "snRNP" EXACT [] xref: Wikipedia:SnRNP is_a: GO:0030529 ! ribonucleoprotein complex is_a: GO:0044428 ! nuclear part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030554 name: adenyl nucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate." [ISBN:0198506732] subset: goslim_chembl subset: gosubset_prok is_a: GO:0017076 ! purine nucleotide binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030611 name: arsenate reductase activity namespace: molecular_function def: "Catalysis of the interconversion of arsenate and arsenite." [GOC:mah] subset: gosubset_prok is_a: GO:0016491 ! oxidoreductase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030702 name: chromatin silencing at centromere namespace: biological_process def: "Repression of transcription of centromeric DNA by altering the structure of chromatin." [GOC:mah] synonym: "centromere chromatin silencing" EXACT [GOC:mah] synonym: "centromeric silencing" EXACT [GOC:vw] synonym: "heterochromatic silencing at centromere" EXACT [] is_a: GO:0006342 ! chromatin silencing property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030705 name: cytoskeleton-dependent intracellular transport namespace: biological_process def: "The directed movement of substances along cytoskeletal elements such as microfilaments or microtubules within a cell." [GOC:mah] subset: goslim_chembl subset: goslim_generic subset: gosubset_prok is_a: GO:1902582 ! single-organism intracellular transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030863 name: cortical cytoskeleton namespace: cellular_component def: "The portion of the cytoskeleton that lies just beneath the plasma membrane." [GOC:mah] is_a: GO:0005856 ! cytoskeleton is_a: GO:0044448 ! cell cortex part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030864 name: cortical actin cytoskeleton namespace: cellular_component def: "The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." [GOC:mah] is_a: GO:0030863 ! cortical cytoskeleton is_a: GO:0044430 ! cytoskeletal part intersection_of: GO:0030863 ! cortical cytoskeleton intersection_of: part_of GO:0015629 ! actin cytoskeleton relationship: part_of GO:0015629 ! actin cytoskeleton property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030865 name: cortical cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] synonym: "cortical cytoskeleton organisation" EXACT [GOC:curators] synonym: "cortical cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007010 ! cytoskeleton organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030866 name: cortical actin cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] synonym: "cortical actin cytoskeleton organisation" EXACT [GOC:curators] synonym: "cortical actin cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0030036 ! actin cytoskeleton organization is_a: GO:0030865 ! cortical cytoskeleton organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030950 name: establishment or maintenance of actin cytoskeleton polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized actin-based cytoskeletal structures." [GOC:mah] is_a: GO:0030036 ! actin cytoskeleton organization is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030952 name: establishment or maintenance of cytoskeleton polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures." [GOC:mah] synonym: "cytoskeleton polarization" RELATED [] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0007163 ! establishment or maintenance of cell polarity is_a: GO:1902589 ! single-organism organelle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030989 name: dynein-driven meiotic oscillatory nuclear movement namespace: biological_process def: "Oscillatory movement of the nucleus involved in meiosis I. This oscillatory movement is led by an astral microtubule array emanating from the spindle pole body, and driven by the microtubule motor cytoplasmic dynein." [GOC:vw, PMID:16111942, PMID:9572142] comment: Dynein-driven meiotic oscillatory nuclear movement precedes meiotic recombination. synonym: "HNM" EXACT [] synonym: "horsetail movement" EXACT [] synonym: "horsetail nuclear movement" EXACT [GOC:vw] is_a: GO:0030473 ! nuclear migration along microtubule is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0007127 ! meiosis I property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030994 name: primary cell septum disassembly namespace: biological_process def: "Dissolution of the primary septum during cell separation." [PMID:12665550] synonym: "hydrolysis of primary cell septum" EXACT [] synonym: "primary cell septum hydrolysis" EXACT [] synonym: "primary septum hydrolysis" BROAD [] is_a: GO:0022411 ! cellular component disassembly relationship: part_of GO:0000920 ! cell separation after cytokinesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030995 name: cell septum edging catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the dissolution of the septum edging during cell separation." [GOC:mah, PMID:15194814] synonym: "cell septum edging hydrolysis" EXACT [] synonym: "hydrolysis of cell septum edging" EXACT [] synonym: "hydrolysis of edging of cell septum" EXACT [] synonym: "septum edging hydrolysis" BROAD [] is_a: GO:0044724 ! single-organism carbohydrate catabolic process is_a: GO:0044763 ! single-organism cellular process is_a: GO:0071999 ! extracellular polysaccharide catabolic process relationship: part_of GO:0000920 ! cell separation after cytokinesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030996 name: mitotic cell cycle arrest in response to nitrogen starvation namespace: biological_process def: "The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of deprivation of nitrogen." [GOC:dph, GOC:mah, GOC:tb, GOC:vw] synonym: "cell cycle arrest in response to nitrogen starvation" BROAD [] is_a: GO:0006995 ! cellular response to nitrogen starvation is_a: GO:0071850 ! mitotic cell cycle arrest property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030998 name: linear element namespace: cellular_component def: "A proteinaceous scaffold associated with S. pombe chromosomes during meiotic prophase. Linear elements have a structure related to but not equivalent to the synaptonemal complex." [GOC:jb] is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000794 ! condensed nuclear chromosome property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0030999 name: linear element assembly namespace: biological_process def: "The cell cycle process in which a proteinaceous scaffold, related to the synaptonemal complex, is assembled in association with S. pombe chromosomes during meiotic prophase." [GOC:jb, GOC:mah] synonym: "linear element formation" RELATED [GOC:dph] is_a: GO:0022607 ! cellular component assembly is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0007129 ! synapsis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031000 name: response to caffeine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [CHEBI:27732, GOC:ef, GOC:mah] is_a: GO:0014074 ! response to purine-containing compound is_a: GO:0043279 ! response to alkaloid property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031023 name: microtubule organizing center organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "microtubule organising center organisation" EXACT [GOC:curators] synonym: "microtubule organizing center organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization relationship: part_of GO:0000226 ! microtubule cytoskeleton organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031032 name: actomyosin structure organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah] comment: Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins. synonym: "actomyosin organization" EXACT [] synonym: "actomyosin structure organisation" EXACT [GOC:curators] synonym: "actomyosin structure organization and biogenesis" RELATED [GOC:mah] is_a: GO:0030036 ! actin cytoskeleton organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031033 name: myosin filament organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a filament composed of myosin molecules." [GOC:mah] comment: Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins; myosin structures are sufficiently closely associated with actin filaments to be included with the actin cytoskeleton. synonym: "myosin filament assembly or disassembly" RELATED [GOC:mah] synonym: "myosin filament organisation" EXACT [GOC:mah] synonym: "myosin polymerization or depolymerization" RELATED [] is_a: GO:0030036 ! actin cytoskeleton organization is_a: GO:0071822 ! protein complex subunit organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031047 name: gene silencing by RNA namespace: biological_process def: "Any process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:mah, GOC:tb, PMID:15020054] synonym: "RNA-mediated gene silencing" EXACT [GOC:dph, GOC:tb] is_a: GO:0016458 ! gene silencing property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031048 name: chromatin silencing by small RNA namespace: biological_process def: "Repression of transcription by conversion of large regions of DNA into heterochromatin, directed by small RNAs sharing sequence identity to the repressed region." [GOC:dph, GOC:mtg_lung, GOC:ns] synonym: "RNA interference-like chromatin silencing" EXACT [] synonym: "RNA-mediated chromatin silencing" EXACT [GOC:dph, GOC:tb] synonym: "RNA-mediated TGS" BROAD [] synonym: "RNA-mediated transcriptional silencing" EXACT [] synonym: "RNAi-directed chromatin silencing" EXACT [GOC:vw] synonym: "RNAi-like chromatin silencing" EXACT [] synonym: "small RNA-mediated heterochromatic silencing" EXACT [] is_a: GO:0006342 ! chromatin silencing is_a: GO:0031047 ! gene silencing by RNA property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031055 name: chromatin remodeling at centromere namespace: biological_process def: "Dynamic structural changes in centromeric DNA." [GOC:mah] is_a: GO:0006338 ! chromatin remodeling property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031081 name: nuclear pore distribution namespace: biological_process def: "Any process that establishes the spatial arrangement of nuclear pores within the nuclear envelope." [GOC:mah] synonym: "positioning of nuclear pores" RELATED [] is_a: GO:0006997 ! nucleus organization is_a: GO:0051664 ! nuclear pore localization is_a: GO:1902580 ! single-organism cellular localization is_a: GO:1902589 ! single-organism organelle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031086 name: nuclear-transcribed mRNA catabolic process, deadenylation-independent decay namespace: biological_process def: "A pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of steps that is independent of deadenylation, but requires decapping followed by transcript decay, and that can regulate mRNA stability." [GOC:krc, PMID:15225542, PMID:15225544] synonym: "deadenylation-independent mRNA decay" EXACT [] synonym: "deadenylylation-independent mRNA decay" EXACT [] synonym: "mRNA breakdown, deadenylation-independent decay" EXACT [] synonym: "mRNA catabolic process, deadenylation-independent" EXACT [] synonym: "mRNA catabolic process, deadenylylation-independent" EXACT [] synonym: "mRNA catabolism, deadenylation-independent" EXACT [] synonym: "mRNA catabolism, deadenylation-independent decay" EXACT [] synonym: "mRNA catabolism, deadenylylation-independent" EXACT [] synonym: "mRNA degradation, deadenylation-independent decay" EXACT [] synonym: "nuclear mRNA catabolic process, deadenylation-independent decay" EXACT [] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031087 name: deadenylation-independent decapping of nuclear-transcribed mRNA namespace: biological_process def: "Cleavage of the 5'-cap of a nuclear-transcribed mRNA that is independent of poly(A) tail shortening." [GOC:krc, PMID:15225542, PMID:15225544] synonym: "deadenylation-independent decapping of nuclear mRNA" RELATED [] synonym: "deadenylylation-independent decapping" EXACT [] is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis relationship: part_of GO:0031086 ! nuclear-transcribed mRNA catabolic process, deadenylation-independent decay property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031090 name: organelle membrane namespace: cellular_component def: "A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah] subset: gosubset_prok synonym: "intracellular membrane" RELATED [NIF_Subcellular:sao830981606] xref: NIF_Subcellular:sao830981606 is_a: GO:0016020 ! membrane is_a: GO:0044422 ! organelle part relationship: part_of GO:0043227 ! membrane-bounded organelle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031097 name: medial cortex namespace: cellular_component def: "A medial cortical band overlaying the nucleus which acts as a landmark for contractile ring positioning and plays a role in cell cycle regulation." [GOC:vw, PMID:15572668, PMID:19474789] synonym: "medial ring" EXACT [GOC:vw] is_a: GO:0032155 ! cell division site part is_a: GO:0099738 ! cell cortex region property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031109 name: microtubule polymerization or depolymerization namespace: biological_process def: "Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031122 name: cytoplasmic microtubule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah] synonym: "cytoplasmic microtubule organisation" EXACT [GOC:curators] synonym: "cytoplasmic microtubule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:0071822 ! protein complex subunit organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031123 name: RNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of an RNA molecule." [GOC:mah] subset: gosubset_prok synonym: "RNA 3' end processing" EXACT [] is_a: GO:0006396 ! RNA processing property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031126 name: snoRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a snoRNA molecule." [GOC:mah] synonym: "snoRNA 3' end processing" EXACT [] is_a: GO:0043144 ! snoRNA processing is_a: GO:0043628 ! ncRNA 3'-end processing property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031134 name: sister chromatid biorientation namespace: biological_process def: "The cell cycle process in which sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles." [PMID:15309047] synonym: "chromosome biorientation" EXACT [] synonym: "sister kinetochore biorientation" EXACT [] is_a: GO:0008608 ! attachment of spindle microtubules to kinetochore relationship: part_of GO:0051310 ! metaphase plate congression property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031137 name: regulation of conjugation with cellular fusion namespace: biological_process def: "Any process that modulates the rate or frequency of conjugation with cellular fusion." [GOC:mah] is_a: GO:0046999 ! regulation of conjugation is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0000747 ! conjugation with cellular fusion relationship: regulates GO:0000747 ! conjugation with cellular fusion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031144 name: proteasome localization namespace: biological_process def: "Any process in which the proteasome is transported to, or maintained in, a specific location." [GOC:mah] synonym: "establishment and maintenance of proteasome localization" EXACT [] synonym: "proteasome localisation" EXACT [GOC:mah] is_a: GO:0034629 ! cellular protein complex localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031145 name: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome." [PMID:15380083] synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein breakdown" EXACT [] synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolism" EXACT [] synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein degradation" EXACT [] synonym: "APC-dependent proteasomal ubiquitin-dependent protein catabolic process" EXACT [] synonym: "APC-dependent proteasomal ubiquitin-dependent protein catabolism" EXACT [] xref: Reactome:REACT_100663 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Bos taurus" xref: Reactome:REACT_101977 "APC/C:Cdc20 mediated degradation of Securin, Gallus gallus" xref: Reactome:REACT_102545 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Danio rerio" xref: Reactome:REACT_103142 "APC/C:Cdc20 mediated degradation of Securin, Danio rerio" xref: Reactome:REACT_105318 "APC/C-mediated degradation of cell cycle proteins, Danio rerio" xref: Reactome:REACT_105606 "APC/C:Cdc20 mediated degradation of Securin, Bos taurus" xref: Reactome:REACT_106319 "APC/C-mediated degradation of cell cycle proteins, Bos taurus" xref: Reactome:REACT_107060 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Mus musculus" xref: Reactome:REACT_107295 "APC/C-mediated degradation of cell cycle proteins, Dictyostelium discoideum" xref: Reactome:REACT_107739 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Rattus norvegicus" xref: Reactome:REACT_108841 "APC/C:Cdc20 mediated degradation of Securin, Canis familiaris" xref: Reactome:REACT_109136 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Gallus gallus" xref: Reactome:REACT_109907 "APC/C:Cdc20 mediated degradation of Securin, Mus musculus" xref: Reactome:REACT_114974 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Oryza sativa" xref: Reactome:REACT_28946 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Rattus norvegicus" xref: Reactome:REACT_29102 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Arabidopsis thaliana" xref: Reactome:REACT_29126 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Xenopus tropicalis" xref: Reactome:REACT_30638 "APC/C:Cdc20 mediated degradation of Cyclin B, Mus musculus" xref: Reactome:REACT_30862 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Taeniopygia guttata" xref: Reactome:REACT_31169 "APC/C-mediated degradation of cell cycle proteins, Canis familiaris" xref: Reactome:REACT_31635 "APC/C-mediated degradation of cell cycle proteins, Mus musculus" xref: Reactome:REACT_33104 "APC/C:Cdc20 mediated degradation of Cyclin B, Drosophila melanogaster" xref: Reactome:REACT_33354 "APC/C:Cdc20 mediated degradation of Cyclin B, Rattus norvegicus" xref: Reactome:REACT_33804 "APC/C:Cdc20 mediated degradation of Cyclin B, Canis familiaris" xref: Reactome:REACT_34466 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Oryza sativa" xref: Reactome:REACT_6761 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Homo sapiens" xref: Reactome:REACT_6820 "APC/C:Cdc20 mediated degradation of Cyclin B, Homo sapiens" xref: Reactome:REACT_6828 "APC/C-mediated degradation of cell cycle proteins, Homo sapiens" xref: Reactome:REACT_6850 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Homo sapiens" xref: Reactome:REACT_6871 "APC/C:Cdc20 mediated degradation of Securin, Homo sapiens" xref: Reactome:REACT_77053 "APC/C-mediated degradation of cell cycle proteins, Drosophila melanogaster" xref: Reactome:REACT_77598 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Gallus gallus" xref: Reactome:REACT_78404 "APC/C-mediated degradation of cell cycle proteins, Rattus norvegicus" xref: Reactome:REACT_79226 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Xenopus tropicalis" xref: Reactome:REACT_80456 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Taeniopygia guttata" xref: Reactome:REACT_82008 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Drosophila melanogaster" xref: Reactome:REACT_82654 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Bos taurus" xref: Reactome:REACT_82931 "APC/C-mediated degradation of cell cycle proteins, Gallus gallus" xref: Reactome:REACT_82967 "APC/C-mediated degradation of cell cycle proteins, Saccharomyces cerevisiae" xref: Reactome:REACT_83315 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Canis familiaris" xref: Reactome:REACT_83601 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Dictyostelium discoideum" xref: Reactome:REACT_83629 "APC/C-mediated degradation of cell cycle proteins, Sus scrofa" xref: Reactome:REACT_84389 "APC/C:Cdc20 mediated degradation of Cyclin B, Xenopus tropicalis" xref: Reactome:REACT_85764 "APC/C-mediated degradation of cell cycle proteins, Schizosaccharomyces pombe" xref: Reactome:REACT_85884 "APC/C:Cdc20 mediated degradation of Securin, Rattus norvegicus" xref: Reactome:REACT_87631 "APC/C:Cdc20 mediated degradation of Cyclin B, Bos taurus" xref: Reactome:REACT_88649 "APC/C-mediated degradation of cell cycle proteins, Xenopus tropicalis" xref: Reactome:REACT_88839 "APC/C:Cdc20 mediated degradation of Cyclin B, Danio rerio" xref: Reactome:REACT_89282 "APC/C:Cdc20 mediated degradation of Cyclin B, Taeniopygia guttata" xref: Reactome:REACT_89743 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Danio rerio" xref: Reactome:REACT_89823 "APC/C-mediated degradation of cell cycle proteins, Oryza sativa" xref: Reactome:REACT_91593 "APC/C:Cdc20 mediated degradation of Securin, Xenopus tropicalis" xref: Reactome:REACT_91603 "APC/C:Cdc20 mediated degradation of Cyclin B, Gallus gallus" xref: Reactome:REACT_91805 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Canis familiaris" xref: Reactome:REACT_92044 "APC/C:Cdc20 mediated degradation of Securin, Drosophila melanogaster" xref: Reactome:REACT_92767 "APC/C-mediated degradation of cell cycle proteins, Taeniopygia guttata" xref: Reactome:REACT_94396 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Drosophila melanogaster" xref: Reactome:REACT_95731 "APC/C-mediated degradation of cell cycle proteins, Arabidopsis thaliana" xref: Reactome:REACT_97054 "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, Mus musculus" xref: Reactome:REACT_97523 "APC/C:Cdc20 mediated degradation of Securin, Taeniopygia guttata" is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031160 name: spore wall namespace: cellular_component def: "The specialized envelope lying outside the cell membrane of a spore." [GOC:mah, GOC:pg] synonym: "spore coat" EXACT [] is_a: GO:0005618 ! cell wall property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031224 name: intrinsic component of membrane namespace: cellular_component def: "The component of a membrane consisting of the gene products having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane." [GOC:mah] comment: Note that proteins intrinsic to membranes cannot be removed without disrupting the membrane, e.g. by detergent. subset: gosubset_prok synonym: "intrinsic to membrane" NARROW [] is_a: GO:0044425 ! membrane part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031261 name: DNA replication preinitiation complex namespace: cellular_component def: "A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present." [GOC:bf, GOC:hjd, GOC:jl, GOC:pr, GOC:rb, GOC:vw, PMID:12694535, PMID:15194812] synonym: "pre-IC" EXACT [] is_a: GO:0032993 ! protein-DNA complex is_a: GO:0044451 ! nucleoplasm part relationship: has_part GO:0005656 ! nuclear pre-replicative complex property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031297 name: replication fork processing namespace: biological_process def: "The process in which a DNA replication fork that has stalled (due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes) is repaired and replication is restarted." [PMID:11459955, PMID:15367656, PMID:17660542] synonym: "collapsed replication fork processing" EXACT [] synonym: "recovery from replication fork arrest" EXACT [] synonym: "recovery from replication fork stalling" EXACT [] synonym: "replication fork restart" RELATED [PMID:20842177] synonym: "replication restart" RELATED [GOC:bhm, PMID:15780929] is_a: GO:0006974 ! cellular response to DNA damage stimulus is_a: GO:0044710 ! single-organism metabolic process is_a: GO:0044763 ! single-organism cellular process is_a: GO:0045005 ! DNA-dependent DNA replication maintenance of fidelity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031321 name: ascospore-type prospore assembly namespace: biological_process def: "During ascospore formation, the process in which each haploid nucleus becomes encapsulated by a double membrane." [GOC:mah, PMID:14702385] synonym: "ascospore-type prospore formation" EXACT [] synonym: "forespore formation" RELATED [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0044702 ! single organism reproductive process is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0030437 ! ascospore formation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031322 name: ascospore-type prospore-specific spindle pole body remodeling namespace: biological_process def: "A spindle pole body (SPB) organization process that takes place during the second meiotic division during ascospore formation and results in the structural reorganization of the SPB; includes the recruitment of sporulation-specific proteins to the outer plaque to form the meiotic outer plaque (MOP)." [GOC:mah, PMID:14702385] synonym: "ascospore-type prospore-specific spindle pole body modification" RELATED [GOC:vw] synonym: "ascospore-type prospore-specific spindle pole body remodelling" EXACT [GOC:mah] synonym: "forespore specific spindle pole body remodeling" EXACT [] synonym: "forespore-specific spindle pole body remodeling" EXACT [] synonym: "prospore-specific spindle pole body remodeling" EXACT [] synonym: "sporulation-specific spindle pole body remodeling" EXACT [] is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0031321 ! ascospore-type prospore assembly relationship: part_of GO:1990395 ! meiotic spindle pole body organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031323 name: regulation of cellular metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah] subset: gosubset_prok synonym: "regulation of cellular metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0044237 ! cellular metabolic process relationship: regulates GO:0044237 ! cellular metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031324 name: negative regulation of cellular metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah] subset: gosubset_prok synonym: "down regulation of cellular metabolic process" EXACT [] synonym: "down-regulation of cellular metabolic process" EXACT [] synonym: "downregulation of cellular metabolic process" EXACT [] synonym: "inhibition of cellular metabolic process" NARROW [] synonym: "negative regulation of cellular metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0044237 ! cellular metabolic process relationship: negatively_regulates GO:0044237 ! cellular metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031325 name: positive regulation of cellular metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah] subset: gosubset_prok synonym: "activation of cellular metabolic process" NARROW [] synonym: "positive regulation of cellular metabolism" EXACT [] synonym: "stimulation of cellular metabolic process" NARROW [] synonym: "up regulation of cellular metabolic process" EXACT [] synonym: "up-regulation of cellular metabolic process" EXACT [] synonym: "upregulation of cellular metabolic process" EXACT [] xref: Reactome:REACT_101225 "ChREBP activates metabolic gene expression, Mus musculus" xref: Reactome:REACT_102187 "ChREBP activates metabolic gene expression, Escherichia coli" xref: Reactome:REACT_102331 "ChREBP activates metabolic gene expression, Caenorhabditis elegans" xref: Reactome:REACT_105293 "ChREBP activates metabolic gene expression, Plasmodium falciparum" xref: Reactome:REACT_108571 "ChREBP activates metabolic gene expression, Drosophila melanogaster" xref: Reactome:REACT_109170 "ChREBP activates metabolic gene expression, Xenopus tropicalis" xref: Reactome:REACT_2122 "ChREBP activates metabolic gene expression, Homo sapiens" xref: Reactome:REACT_28360 "ChREBP activates metabolic gene expression, Arabidopsis thaliana" xref: Reactome:REACT_31270 "ChREBP activates metabolic gene expression, Mycobacterium tuberculosis" xref: Reactome:REACT_79603 "ChREBP activates metabolic gene expression, Canis familiaris" xref: Reactome:REACT_80902 "ChREBP activates metabolic gene expression, Saccharomyces cerevisiae" xref: Reactome:REACT_83058 "ChREBP activates metabolic gene expression, Taeniopygia guttata" xref: Reactome:REACT_84314 "ChREBP activates metabolic gene expression, Oryza sativa" xref: Reactome:REACT_86633 "ChREBP activates metabolic gene expression, Dictyostelium discoideum" xref: Reactome:REACT_87840 "ChREBP activates metabolic gene expression, Danio rerio" xref: Reactome:REACT_88060 "ChREBP activates metabolic gene expression, Rattus norvegicus" xref: Reactome:REACT_91293 "ChREBP activates metabolic gene expression, Staphylococcus aureus N315" xref: Reactome:REACT_91429 "ChREBP activates metabolic gene expression, Gallus gallus" xref: Reactome:REACT_91906 "ChREBP activates metabolic gene expression, Schizosaccharomyces pombe" xref: Reactome:REACT_92487 "ChREBP activates metabolic gene expression, Bos taurus" xref: Reactome:REACT_99393 "ChREBP activates metabolic gene expression, Sus scrofa" is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0044237 ! cellular metabolic process relationship: positively_regulates GO:0044237 ! cellular metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031326 name: regulation of cellular biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah] subset: gosubset_prok synonym: "regulation of cellular anabolism" EXACT [] synonym: "regulation of cellular biosynthesis" EXACT [] synonym: "regulation of cellular formation" EXACT [] synonym: "regulation of cellular synthesis" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0044249 ! cellular biosynthetic process relationship: regulates GO:0044249 ! cellular biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031327 name: negative regulation of cellular biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah] subset: gosubset_prok synonym: "down regulation of cellular biosynthetic process" EXACT [] synonym: "down-regulation of cellular biosynthetic process" EXACT [] synonym: "downregulation of cellular biosynthetic process" EXACT [] synonym: "inhibition of cellular biosynthetic process" NARROW [] synonym: "negative regulation of cellular anabolism" EXACT [] synonym: "negative regulation of cellular biosynthesis" EXACT [] synonym: "negative regulation of cellular formation" EXACT [] synonym: "negative regulation of cellular synthesis" EXACT [] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0044249 ! cellular biosynthetic process relationship: negatively_regulates GO:0044249 ! cellular biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031328 name: positive regulation of cellular biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah] subset: gosubset_prok synonym: "activation of cellular biosynthetic process" NARROW [] synonym: "positive regulation of cellular anabolism" EXACT [] synonym: "positive regulation of cellular biosynthesis" EXACT [] synonym: "positive regulation of cellular formation" EXACT [] synonym: "positive regulation of cellular synthesis" EXACT [] synonym: "stimulation of cellular biosynthetic process" NARROW [] synonym: "up regulation of cellular biosynthetic process" EXACT [] synonym: "up-regulation of cellular biosynthetic process" EXACT [] synonym: "upregulation of cellular biosynthetic process" EXACT [] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0044249 ! cellular biosynthetic process relationship: positively_regulates GO:0044249 ! cellular biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031329 name: regulation of cellular catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah] subset: gosubset_prok synonym: "regulation of cellular breakdown" EXACT [] synonym: "regulation of cellular catabolism" EXACT [] synonym: "regulation of cellular degradation" EXACT [] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0044248 ! cellular catabolic process relationship: regulates GO:0044248 ! cellular catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031330 name: negative regulation of cellular catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah] subset: gosubset_prok synonym: "down regulation of cellular catabolic process" EXACT [] synonym: "down-regulation of cellular catabolic process" EXACT [] synonym: "downregulation of cellular catabolic process" EXACT [] synonym: "inhibition of cellular catabolic process" NARROW [] synonym: "negative regulation of cellular breakdown" EXACT [] synonym: "negative regulation of cellular catabolism" EXACT [] synonym: "negative regulation of cellular degradation" EXACT [] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0031329 ! regulation of cellular catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0044248 ! cellular catabolic process relationship: negatively_regulates GO:0044248 ! cellular catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031331 name: positive regulation of cellular catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah] subset: gosubset_prok synonym: "activation of cellular catabolic process" NARROW [] synonym: "positive regulation of cellular breakdown" EXACT [] synonym: "positive regulation of cellular catabolism" EXACT [] synonym: "positive regulation of cellular degradation" EXACT [] synonym: "stimulation of cellular catabolic process" NARROW [] synonym: "up regulation of cellular catabolic process" EXACT [] synonym: "up-regulation of cellular catabolic process" EXACT [] synonym: "upregulation of cellular catabolic process" EXACT [] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0031329 ! regulation of cellular catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0044248 ! cellular catabolic process relationship: positively_regulates GO:0044248 ! cellular catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031382 name: mating projection assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a cell projection in response to mating pheromone. This process is observed in unicellular fungi." [GOC:mah, PMID:14734532] synonym: "mating projection biogenesis" RELATED [GOC:mah] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0030031 ! cell projection assembly is_a: GO:0044702 ! single organism reproductive process relationship: part_of GO:0000753 ! cell morphogenesis involved in conjugation with cellular fusion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031396 name: regulation of protein ubiquitination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016567 ! protein ubiquitination relationship: regulates GO:0016567 ! protein ubiquitination property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031397 name: negative regulation of protein ubiquitination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] synonym: "down regulation of protein ubiquitination" EXACT [] synonym: "down-regulation of protein ubiquitination" EXACT [] synonym: "downregulation of protein ubiquitination" EXACT [] synonym: "inhibition of protein ubiquitination" NARROW [] is_a: GO:0031396 ! regulation of protein ubiquitination is_a: GO:1903321 ! negative regulation of protein modification by small protein conjugation or removal intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0016567 ! protein ubiquitination relationship: negatively_regulates GO:0016567 ! protein ubiquitination property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031399 name: regulation of protein modification process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] subset: goslim_yeast subset: gosubset_prok is_a: GO:0032268 ! regulation of cellular protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006464 ! cellular protein modification process relationship: regulates GO:0006464 ! cellular protein modification process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031400 name: negative regulation of protein modification process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] synonym: "down regulation of protein modification" EXACT [] synonym: "down-regulation of protein modification" EXACT [] synonym: "downregulation of protein modification" EXACT [] synonym: "inhibition of protein modification" NARROW [] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0032269 ! negative regulation of cellular protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006464 ! cellular protein modification process relationship: negatively_regulates GO:0006464 ! cellular protein modification process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031406 name: carboxylic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732] subset: goslim_pir subset: gosubset_prok is_a: GO:0043168 ! anion binding is_a: GO:0043177 ! organic acid binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031410 name: cytoplasmic vesicle namespace: cellular_component def: "A vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:mah] subset: gosubset_prok xref: NIF_Subcellular:sao180601769 is_a: GO:0031982 ! vesicle is_a: GO:0043229 ! intracellular organelle is_a: GO:0044444 ! cytoplasmic part intersection_of: GO:0031982 ! vesicle intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005737 ! cytoplasm property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031491 name: nucleosome binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:mah] is_a: GO:0003682 ! chromatin binding is_a: GO:0032403 ! protein complex binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031494 name: regulation of mating type switching namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mating type switching, the conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus." [GOC:mah] is_a: GO:0010453 ! regulation of cell fate commitment is_a: GO:0051052 ! regulation of DNA metabolic process is_a: GO:2000241 ! regulation of reproductive process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007533 ! mating type switching relationship: regulates GO:0007533 ! mating type switching property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031497 name: chromatin assembly namespace: biological_process def: "The assembly of DNA, histone proteins, other associated proteins, and sometimes RNA, into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus." [http://www.infobiogen.fr/services/chromcancer/IntroItems/ChromatinEducEng.html, PMID:20404130] synonym: "establishment of chromatin architecture" EXACT [GOC:mah] is_a: GO:0006333 ! chromatin assembly or disassembly is_a: GO:0065003 ! macromolecular complex assembly relationship: part_of GO:0006323 ! DNA packaging property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031503 name: protein complex localization namespace: biological_process def: "A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location." [GOC:mah] subset: gosubset_prok synonym: "establishment and maintenance of protein complex localization" EXACT [] synonym: "protein complex localisation" EXACT [GOC:mah] is_a: GO:0008104 ! protein localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031505 name: fungal-type cell wall organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall." [GOC:dph, GOC:jl, GOC:mah, GOC:mtg_sensu] synonym: "beta-glucan-containing cell wall organization and biogenesis" RELATED [] synonym: "chitin- and beta-glucan-containing cell wall organisation" NARROW [] synonym: "chitin- and beta-glucan-containing cell wall organization and biogenesis" NARROW [] synonym: "chitin-containing cell wall organization and biogenesis" RELATED [] synonym: "fungal-type cell wall organization and biogenesis" RELATED [] is_a: GO:0071555 ! cell wall organization is_a: GO:0071852 ! fungal-type cell wall organization or biogenesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031507 name: heterochromatin assembly namespace: biological_process def: "The assembly of chromatin into heterochromatin, a compact and highly condensed form that is often, but not always, transcriptionally silent." [GOC:mah] synonym: "establishment of heterochromatin architecture" EXACT [GOC:mah] synonym: "heterochromatin formation" EXACT [] is_a: GO:0006338 ! chromatin remodeling is_a: GO:0031497 ! chromatin assembly is_a: GO:0070828 ! heterochromatin organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031570 name: DNA integrity checkpoint namespace: biological_process def: "A cell cycle process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes." [GOC:mtg_cell_cycle] is_a: GO:0000075 ! cell cycle checkpoint property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031572 name: G2 DNA damage checkpoint namespace: biological_process def: "A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase in the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] comment: Note that this term should only be used as a grouping term for the mitotic and meiotic G2 DNA damage checkpoints, and should not be used for direct manual annotation. You should always be able to choose one of its child terms instead. subset: gocheck_do_not_manually_annotate synonym: "G2/M transition DNA damage checkpoint" EXACT [] is_a: GO:0000077 ! DNA damage checkpoint property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031573 name: intra-S DNA damage checkpoint namespace: biological_process def: "A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression." [GOC:vw] synonym: "mitotic intra-S DNA damage checkpoint" EXACT [] synonym: "S-phase checkpoint" BROAD [] is_a: GO:0044773 ! mitotic DNA damage checkpoint property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031577 name: spindle checkpoint namespace: biological_process def: "A cell cycle checkpoint that originates from the mitotic or meiotic spindle." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct manual annotation as it should always be possible to choose either a mitotic or meiotic child term. subset: gocheck_do_not_manually_annotate xref: Wikipedia:Spindle_checkpoint is_a: GO:0000075 ! cell cycle checkpoint property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031582 name: replication fork arrest at rDNA repeats namespace: biological_process def: "A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic rDNA repeat spacer." [GOC:mah, GOC:vw] synonym: "replication fork arrest at ribosomal DNA repeats" EXACT [] synonym: "replication fork blocking at rDNA repeats" EXACT [] is_a: GO:0043007 ! maintenance of rDNA is_a: GO:0043111 ! replication fork arrest property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031589 name: cell-substrate adhesion namespace: biological_process def: "The attachment of a cell to the underlying substrate via adhesion molecules." [GOC:mah, GOC:pf] subset: gosubset_prok is_a: GO:0007155 ! cell adhesion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031619 name: homologous chromosome orientation involved in meiotic metaphase I plate congression namespace: biological_process def: "The cell cycle process in which the sister centromeres of one chromosome attach to microtubules that emanate from the same spindle pole, which ensures that homologous maternal and paternal chromosomes are pulled in opposite directions at anaphase of meiosis I." [PMID:15062096] synonym: "homologous chromosome orientation during meiosis" RELATED [GOC:dph, GOC:tb] synonym: "homologous chromosome orientation during meiosis I" RELATED [] is_a: GO:0051455 ! attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation relationship: part_of GO:0043060 ! meiotic metaphase I plate congression property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031667 name: response to nutrient levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah] subset: gosubset_prok is_a: GO:0009991 ! response to extracellular stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031668 name: cellular response to extracellular stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus." [GOC:mah] subset: gosubset_prok is_a: GO:0007154 ! cell communication is_a: GO:0009991 ! response to extracellular stimulus is_a: GO:0051716 ! cellular response to stimulus is_a: GO:0071496 ! cellular response to external stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031669 name: cellular response to nutrient levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah] subset: gosubset_prok is_a: GO:0031667 ! response to nutrient levels is_a: GO:0031668 ! cellular response to extracellular stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031670 name: cellular response to nutrient namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:mah] is_a: GO:0007584 ! response to nutrient is_a: GO:0031669 ! cellular response to nutrient levels is_a: GO:0070887 ! cellular response to chemical stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031671 name: primary cell septum biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a primary cell septum following nuclear division." [GOC:jl] is_a: GO:0044085 ! cellular component biogenesis is_a: GO:1902410 ! mitotic cytokinetic process relationship: part_of GO:0000917 ! barrier septum assembly relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031919 name: vitamin B6 transport namespace: biological_process def: "The directed movement of any of the vitamin B6 compounds -- pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate -- into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0051180 ! vitamin transport is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031923 name: pyridoxine transport namespace: biological_process def: "The directed movement of pyridoxine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0031919 ! vitamin B6 transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031934 name: mating-type region heterochromatin namespace: cellular_component def: "Heterochromatic regions of the chromosome found at silenced mating-type loci." [GOC:mah] is_a: GO:0000792 ! heterochromatin property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031941 name: filamentous actin namespace: cellular_component def: "A two-stranded helical polymer of the protein actin." [GOC:mah] comment: Note that this term refers only to the actin portion of a microfilament, and does not encompass associated proteins. See also the cellular component term 'actin filament ; GO:0005884'. synonym: "F-actin" EXACT [] xref: Wikipedia:Actin is_a: GO:0043234 ! protein complex is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0005884 ! actin filament property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031952 name: regulation of protein autophosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues." [GOC:mah] synonym: "regulation of protein amino acid autophosphorylation" EXACT [GOC:bf] is_a: GO:0001932 ! regulation of protein phosphorylation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0046777 ! protein autophosphorylation relationship: regulates GO:0046777 ! protein autophosphorylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031965 name: nuclear membrane namespace: cellular_component def: "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz] xref: NIF_Subcellular:sao1687101204 is_a: GO:0031090 ! organelle membrane is_a: GO:0044428 ! nuclear part relationship: part_of GO:0005635 ! nuclear envelope property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031966 name: mitochondrial membrane namespace: cellular_component def: "Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829] xref: NIF_Subcellular:sao1045389829 is_a: GO:0031090 ! organelle membrane is_a: GO:0044429 ! mitochondrial part relationship: part_of GO:0005740 ! mitochondrial envelope property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031967 name: organelle envelope namespace: cellular_component def: "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz] subset: gosubset_prok is_a: GO:0031975 ! envelope is_a: GO:0044446 ! intracellular organelle part relationship: part_of GO:0043227 ! membrane-bounded organelle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031974 name: membrane-enclosed lumen namespace: cellular_component def: "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] is_a: GO:0005575 ! cellular_component property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031975 name: envelope namespace: cellular_component def: "A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers." [GOC:mah, GOC:pz] subset: gosubset_prok is_a: GO:0044464 ! cell part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031981 name: nuclear lumen namespace: cellular_component def: "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] is_a: GO:0044428 ! nuclear part is_a: GO:0070013 ! intracellular organelle lumen property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031982 name: vesicle namespace: cellular_component def: "Any small, fluid-filled, spherical organelle enclosed by membrane or protein." [GOC:mah, GOC:pz] subset: goslim_metagenomics subset: goslim_pir subset: gosubset_prok xref: NIF_Subcellular:sao221389602 xref: Wikipedia:Vesicle_(biology) is_a: GO:0043226 ! organelle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031984 name: organelle subcompartment namespace: cellular_component def: "A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle." [GOC:mah, GOC:pz] comment: Note that this term refers to membrane-bounded compartments that are not considered organelles in their own right, but form parts of larger organelles. synonym: "suborganelle compartment" EXACT [] is_a: GO:0044446 ! intracellular organelle part relationship: part_of GO:0043227 ! membrane-bounded organelle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031985 name: Golgi cisterna namespace: cellular_component def: "Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah] synonym: "Golgi lamellae" RELATED [NIF_Subcellular:sao561419532] xref: NIF_Subcellular:sao561419532 is_a: GO:0098791 ! Golgi subcompartment relationship: part_of GO:0005795 ! Golgi stack property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0031988 name: membrane-bounded vesicle namespace: cellular_component def: "Any small, fluid-filled, spherical organelle enclosed by a lipid bilayer." [GOC:mah] subset: gosubset_prok synonym: "membrane-enclosed vesicle" EXACT [] is_a: GO:0031982 ! vesicle is_a: GO:0043227 ! membrane-bounded organelle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032120 name: ascospore-type prospore membrane assembly namespace: biological_process def: "The process in which the nascent membrane forms at the meiotic outer plaque and grows until closure occurs and forespores, or prospores, are formed." [GOC:clt] synonym: "forespore membrane biosynthesis" EXACT [] synonym: "forespore membrane formation" EXACT [] synonym: "FSM assembly" EXACT [] synonym: "FSM biosynthesis" EXACT [] synonym: "FSM formation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0044702 ! single organism reproductive process is_a: GO:0071709 ! membrane assembly is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0031321 ! ascospore-type prospore assembly property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032121 name: attachment of telomeric heterochromatin to spindle pole body namespace: biological_process def: "The cell cycle process in which physical connections are formed between telomeric heterochromatin and the spindle pole body, facilitating bouquet formation." [GOC:pr, PMID:16615890] synonym: "attachment of telomeres to spindle pole body" BROAD [] synonym: "attachment of telomeric chromatin to spindle pole body" BROAD [] is_a: GO:0007017 ! microtubule-based process is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0045141 ! meiotic telomere clustering property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032126 name: eisosome namespace: cellular_component def: "A cell part that is composed of the eisosome membrane or MCC domain, a furrow-like plasma membrane sub-domain and associated integral transmembrane proteins, and the proteins (eisosome filaments) that form a scaffolding lattice on the cytoplasmic face. Eisosomes broadly affect overall plasma membrane organization." [GOC:al, GOC:vw, PMID:16496001, PMID:22368779] xref: Wikipedia:Eisosome is_a: GO:0044464 ! cell part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032153 name: cell division site namespace: cellular_component def: "The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles." [GOC:bf, GOC:imk, GOC:krc, GOC:ns, PMID:12101122, PMID:15380095, PMID:16983191, PMID:18165305] comment: Note that this term refers to the future site of division in a cell that has not yet divided. subset: goslim_pir synonym: "cell division plane" EXACT [] is_a: GO:0044464 ! cell part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032155 name: cell division site part namespace: cellular_component def: "Any constituent part of the cell division plane, the eventual plane of cell division in a dividing cell." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: goantislim_grouping subset: gocheck_do_not_annotate synonym: "cell division plane part" EXACT [] is_a: GO:0044464 ! cell part intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0032153 ! cell division site relationship: part_of GO:0032153 ! cell division site property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032187 name: actomyosin contractile ring localization namespace: biological_process def: "The process in which a contractile ring is assembled and/or maintained in a specific location, in the context of cytokinesis that takes place as part of a cell cycle." [GOC:mah] synonym: "contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:mah] synonym: "contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw] is_a: GO:0036214 ! contractile ring localization is_a: GO:1902580 ! single-organism cellular localization relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032196 name: transposition namespace: biological_process def: "Any process involved in mediating the movement of discrete segments of DNA between nonhomologous sites." [GOC:jp, ISBN:1555812090] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast subset: gosubset_prok xref: Wikipedia:Transposon is_a: GO:0044763 ! single-organism cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032200 name: telomere organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_pombe subset: goslim_yeast synonym: "chromosome organization, telomeric" EXACT [] synonym: "organization of chromosome, telomeric region" EXACT [] synonym: "telomere organisation" EXACT [GOC:mah] synonym: "telomere organization and biogenesis" RELATED [GOC:mah] is_a: GO:0051276 ! chromosome organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032220 name: plasma membrane fusion involved in cytogamy namespace: biological_process def: "The joining of two or more lipid bilayer membranes that surround cells, that contributes to cytogamy." [GOC:mah] synonym: "plasma membrane fusion during cytogamy" RELATED [GOC:dph, GOC:tb] is_a: GO:0045026 ! plasma membrane fusion intersection_of: GO:0045026 ! plasma membrane fusion intersection_of: part_of GO:0000755 ! cytogamy relationship: part_of GO:0000755 ! cytogamy property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032259 name: methylation namespace: biological_process def: "The process in which a methyl group is covalently attached to a molecule." [GOC:mah] subset: goslim_chembl xref: Reactome:REACT_100463 "Methylation, Rattus norvegicus" xref: Reactome:REACT_104378 "Methylation, Staphylococcus aureus N315" xref: Reactome:REACT_106986 "Methylation, Schizosaccharomyces pombe" xref: Reactome:REACT_107353 "Methylation, Taeniopygia guttata" xref: Reactome:REACT_107808 "Methylation, Caenorhabditis elegans" xref: Reactome:REACT_110691 "Methylation, Gallus gallus" xref: Reactome:REACT_34638 "Methylation, Mus musculus" xref: Reactome:REACT_6946 "Methylation, Homo sapiens" xref: Reactome:REACT_77304 "Methylation, Oryza sativa" xref: Reactome:REACT_78116 "Methylation, Xenopus tropicalis" xref: Reactome:REACT_87183 "Methylation, Drosophila melanogaster" xref: Reactome:REACT_88148 "Methylation, Canis familiaris" xref: Reactome:REACT_90436 "Methylation, Danio rerio" xref: Reactome:REACT_92149 "Methylation, Sus scrofa" xref: Reactome:REACT_92596 "Methylation, Escherichia coli" xref: Reactome:REACT_93357 "Methylation, Mycobacterium tuberculosis" xref: Reactome:REACT_95391 "Methylation, Saccharomyces cerevisiae" xref: Reactome:REACT_98332 "Methylation, Arabidopsis thaliana" xref: Reactome:REACT_99471 "Methylation, Bos taurus" xref: Reactome:REACT_99529 "Methylation, Dictyostelium discoideum" xref: Wikipedia:Methylation is_a: GO:0008152 ! metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032268 name: regulation of cellular protein metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah] subset: gosubset_prok synonym: "regulation of cellular protein metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0044267 ! cellular protein metabolic process relationship: regulates GO:0044267 ! cellular protein metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032269 name: negative regulation of cellular protein metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah] synonym: "down regulation of cellular protein metabolic process" EXACT [] synonym: "down-regulation of cellular protein metabolic process" EXACT [] synonym: "downregulation of cellular protein metabolic process" EXACT [] synonym: "inhibition of cellular protein metabolic process" NARROW [] synonym: "negative regulation of cellular protein metabolism" EXACT [] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0032268 ! regulation of cellular protein metabolic process is_a: GO:0051248 ! negative regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0044267 ! cellular protein metabolic process relationship: negatively_regulates GO:0044267 ! cellular protein metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032270 name: positive regulation of cellular protein metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah] synonym: "activation of cellular protein metabolic process" NARROW [] synonym: "positive regulation of cellular protein metabolism" EXACT [] synonym: "stimulation of cellular protein metabolic process" NARROW [] synonym: "up regulation of cellular protein metabolic process" EXACT [] synonym: "up-regulation of cellular protein metabolic process" EXACT [] synonym: "upregulation of cellular protein metabolic process" EXACT [] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0032268 ! regulation of cellular protein metabolic process is_a: GO:0051247 ! positive regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0044267 ! cellular protein metabolic process relationship: positively_regulates GO:0044267 ! cellular protein metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032297 name: negative regulation of DNA-dependent DNA replication initiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of initiation of DNA-dependent DNA replication." [GOC:mah] synonym: "down regulation of DNA replication initiation" EXACT [] synonym: "down-regulation of DNA replication initiation" EXACT [] synonym: "downregulation of DNA replication initiation" EXACT [] synonym: "inhibition of DNA replication initiation" NARROW [] synonym: "negative regulation of DNA replication initiation" BROAD [GOC:vw] is_a: GO:0030174 ! regulation of DNA-dependent DNA replication initiation is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006270 ! DNA replication initiation relationship: negatively_regulates GO:0006270 ! DNA replication initiation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032329 name: serine transport namespace: biological_process def: "The directed movement of L-serine, 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0006812 ! cation transport is_a: GO:0015804 ! neutral amino acid transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032392 name: DNA geometric change namespace: biological_process def: "The process in which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases." [GOC:mah] comment: Note that DNA geometric change and DNA topological change (GO:0006265) are distinct, but are usually coupled in vivo. subset: goslim_pir is_a: GO:0071103 ! DNA conformation change property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032403 name: protein complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:mah] subset: goslim_chembl is_a: GO:0005515 ! protein binding is_a: GO:0044877 ! macromolecular complex binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032432 name: actin filament bundle namespace: cellular_component alt_id: GO:0000141 alt_id: GO:0030482 def: "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:mah] synonym: "actin cable" RELATED [GOC:mah] is_a: GO:0044430 ! cytoskeletal part relationship: has_part GO:0005884 ! actin filament relationship: part_of GO:0015629 ! actin cytoskeleton property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032434 name: regulation of proteasomal ubiquitin-dependent protein catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] is_a: GO:0061136 ! regulation of proteasomal protein catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process relationship: regulates GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032435 name: negative regulation of proteasomal ubiquitin-dependent protein catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] synonym: "down regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] synonym: "down-regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] synonym: "downregulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] synonym: "inhibition of proteasomal ubiquitin-dependent protein catabolic process" NARROW [] is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process is_a: GO:1901799 ! negative regulation of proteasomal protein catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process relationship: negatively_regulates GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032436 name: positive regulation of proteasomal ubiquitin-dependent protein catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] synonym: "activation of proteasomal ubiquitin-dependent protein catabolic process" NARROW [] synonym: "stimulation of proteasomal ubiquitin-dependent protein catabolic process" NARROW [] synonym: "up regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] synonym: "up-regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] synonym: "upregulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process is_a: GO:1901800 ! positive regulation of proteasomal protein catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process relationship: positively_regulates GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032446 name: protein modification by small protein conjugation namespace: biological_process def: "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah] is_a: GO:0070647 ! protein modification by small protein conjugation or removal property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032450 name: maltose alpha-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose." [MetaCyc:RXN-2141] synonym: "maltase activity" EXACT [] xref: EC:3.2.1.20 xref: MetaCyc:RXN-2141 is_a: GO:0090599 ! alpha-glucosidase activity relationship: part_of GO:0000023 ! maltose metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032465 name: regulation of cytokinesis namespace: biological_process alt_id: GO:0071775 def: "Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells." [GOC:mah] synonym: "regulation of cell cycle cytokinesis" EXACT [] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0000910 ! cytokinesis relationship: regulates GO:0000910 ! cytokinesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032501 name: multicellular organismal process namespace: biological_process alt_id: GO:0050874 def: "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb] subset: goslim_pir synonym: "organismal physiological process" EXACT [] is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032502 name: developmental process namespace: biological_process def: "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete] subset: goslim_aspergillus subset: goslim_pir subset: gosubset_prok synonym: "development" NARROW [] is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032505 name: reproduction of a single-celled organism namespace: biological_process def: "The biological process in which new individuals are produced by one or two single-celled organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete] subset: gosubset_prok is_a: GO:0000003 ! reproduction property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032506 name: cytokinetic process namespace: biological_process def: "A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells)." [GOC:bf, GOC:isa_complete, GOC:mah] subset: gosubset_prok is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0000910 ! cytokinesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032507 name: maintenance of protein location in cell namespace: biological_process def: "Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:isa_complete, GOC:mah] synonym: "maintenance of protein localization in cell" RELATED [GOC:dph, GOC:tb] is_a: GO:0045185 ! maintenance of protein location is_a: GO:0051651 ! maintenance of location in cell intersection_of: GO:0045185 ! maintenance of protein location intersection_of: occurs_in GO:0005623 ! cell relationship: occurs_in GO:0005623 ! cell relationship: part_of GO:0034613 ! cellular protein localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032508 name: DNA duplex unwinding namespace: biological_process def: "The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah] comment: Note that this term refers to a geometric change in DNA conformation, and should not be confused with 'DNA topological change ; GO:0006265'. synonym: "DNA unwinding" EXACT [] synonym: "duplex DNA melting" EXACT [] is_a: GO:0032392 ! DNA geometric change property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032509 name: endosome transport via multivesicular body sorting pathway namespace: biological_process def: "The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637] synonym: "endosome transport via MVB sorting pathway" EXACT [] is_a: GO:0016197 ! endosomal transport relationship: has_part GO:0071985 ! multivesicular body sorting pathway property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032511 name: late endosome to vacuole transport via multivesicular body sorting pathway namespace: biological_process def: "The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole." [GOC:mah, PMID:12461556, PMID:16689637] synonym: "endosome to vacuole transport via MVB sorting pathway" EXACT [] is_a: GO:0032509 ! endosome transport via multivesicular body sorting pathway is_a: GO:0045324 ! late endosome to vacuole transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032543 name: mitochondrial translation namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators] subset: goslim_yeast synonym: "mitochondrial protein anabolism" EXACT [] synonym: "mitochondrial protein biosynthesis" EXACT [] synonym: "mitochondrial protein formation" EXACT [] synonym: "mitochondrial protein synthesis" EXACT [] synonym: "mitochondrial protein translation" EXACT [] is_a: GO:0006412 ! translation is_a: GO:0007005 ! mitochondrion organization is_a: GO:0044711 ! single-organism biosynthetic process is_a: GO:1902589 ! single-organism organelle organization intersection_of: GO:0006412 ! translation intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032549 name: ribonucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose." [GOC:mah] subset: gosubset_prok is_a: GO:0001882 ! nucleoside binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032550 name: purine ribonucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a purine ribonucleoside, a compound consisting of a purine base linked to ribose." [GOC:mah] subset: gosubset_prok is_a: GO:0001883 ! purine nucleoside binding is_a: GO:0032549 ! ribonucleoside binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032553 name: ribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] subset: gosubset_prok is_a: GO:0000166 ! nucleotide binding is_a: GO:0097367 ! carbohydrate derivative binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032555 name: purine ribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] subset: gosubset_prok is_a: GO:0017076 ! purine nucleotide binding is_a: GO:0032553 ! ribonucleotide binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032559 name: adenyl ribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] subset: gosubset_prok is_a: GO:0030554 ! adenyl nucleotide binding is_a: GO:0032555 ! purine ribonucleotide binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032561 name: guanyl ribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] subset: gosubset_prok is_a: GO:0019001 ! guanyl nucleotide binding is_a: GO:0032555 ! purine ribonucleotide binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032774 name: RNA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH] comment: Note that, in some cases, viral RNA replication and viral transcription from RNA actually refer to the same process, but may be called differently depending on the focus of a specific research study. synonym: "RNA anabolism" EXACT [] synonym: "RNA biosynthesis" EXACT [] synonym: "RNA formation" EXACT [] synonym: "RNA synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0016070 ! RNA metabolic process is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032781 name: positive regulation of ATPase activity namespace: biological_process def: "Any process that activates or increases the rate of ATP hydrolysis by an ATPase." [GOC:mah] synonym: "activation of ATPase activity" NARROW [] synonym: "positive regulation of adenosinetriphosphatase activity" EXACT [] synonym: "stimulation of ATPase activity" NARROW [] synonym: "up regulation of ATPase activity" EXACT [] synonym: "up-regulation of ATPase activity" EXACT [] synonym: "upregulation of ATPase activity" EXACT [] is_a: GO:0043462 ! regulation of ATPase activity is_a: GO:0051345 ! positive regulation of hydrolase activity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0016887 ! ATPase activity relationship: positively_regulates GO:0016887 ! ATPase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032787 name: monocarboxylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:vk] subset: goslim_yeast subset: gosubset_prok synonym: "monocarboxylate metabolic process" EXACT [] synonym: "monocarboxylic acid metabolism" EXACT [] is_a: GO:0019752 ! carboxylic acid metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032878 name: regulation of establishment or maintenance of cell polarity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007163 ! establishment or maintenance of cell polarity relationship: regulates GO:0007163 ! establishment or maintenance of cell polarity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032934 name: sterol binding namespace: molecular_function alt_id: GO:0005498 def: "Interacting selectively and non-covalently with a sterol, any steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol." [CHEBI:15889, GOC:mah] subset: gosubset_prok synonym: "sterol carrier activity" RELATED [GOC:mah] is_a: GO:0005496 ! steroid binding is_a: GO:0043178 ! alcohol binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032940 name: secretion by cell namespace: biological_process def: "The controlled release of a substance by a cell." [GOC:mah] synonym: "cellular secretion" EXACT [] xref: Wikipedia:Secretion is_a: GO:0044763 ! single-organism cellular process is_a: GO:0046903 ! secretion is_a: GO:0051649 ! establishment of localization in cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032984 name: macromolecular complex disassembly namespace: biological_process alt_id: GO:0034623 def: "The disaggregation of a macromolecular complex into its constituent components." [GOC:mah] subset: gosubset_prok synonym: "cellular macromolecular complex disassembly" EXACT [] synonym: "cellular macromolecule complex disassembly" EXACT [] synonym: "macromolecule complex disassembly" EXACT [] is_a: GO:0022411 ! cellular component disassembly is_a: GO:0043933 ! macromolecular complex subunit organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032988 name: ribonucleoprotein complex disassembly namespace: biological_process def: "The disaggregation of a protein-RNA complex into its constituent components." [GOC:mah] synonym: "protein-RNA complex disassembly" EXACT [] synonym: "RNA-protein complex disassembly" EXACT [] synonym: "RNP complex disassembly" EXACT [] is_a: GO:0032984 ! macromolecular complex disassembly is_a: GO:0071826 ! ribonucleoprotein complex subunit organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032989 name: cellular component morphogenesis namespace: biological_process def: "The process in which cellular structures, including whole cells or cell parts, are generated and organized." [GOC:dph, GOC:mah, GOC:tb] subset: goslim_pir subset: gosubset_prok synonym: "cellular structure morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0016043 ! cellular component organization is_a: GO:0048869 ! cellular developmental process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032991 name: macromolecular complex namespace: cellular_component def: "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together." [GOC:mah] subset: goslim_pir subset: gosubset_prok synonym: "macromolecule complex" EXACT [] is_a: GO:0005575 ! cellular_component property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0032993 name: protein-DNA complex namespace: cellular_component def: "A macromolecular complex containing both protein and DNA molecules." [GOC:mah] comment: Note that this term is intended to classify complexes that have DNA as one of the members of the complex, that is, the complex does not exist if DNA is not present. Protein complexes that interact with DNA e.g. transcription factor complexes should not be classified here. subset: gosubset_prok synonym: "DNA-protein complex" EXACT [GOC:mah] is_a: GO:0032991 ! macromolecular complex property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0033036 name: macromolecule localization namespace: biological_process def: "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah] subset: gosubset_prok synonym: "macromolecule localisation" EXACT [GOC:mah] is_a: GO:0051179 ! localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0033043 name: regulation of organelle organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] subset: goslim_yeast synonym: "regulation of organelle organisation" EXACT [GOC:mah] synonym: "regulation of organelle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006996 ! organelle organization relationship: regulates GO:0006996 ! organelle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0033044 name: regulation of chromosome organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah] synonym: "regulation of chromosome organisation" EXACT [GOC:mah] synonym: "regulation of chromosome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0051276 ! chromosome organization relationship: regulates GO:0051276 ! chromosome organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0033045 name: regulation of sister chromatid segregation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation." [GOC:mah] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0033044 ! regulation of chromosome organization is_a: GO:0051983 ! regulation of chromosome segregation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0000819 ! sister chromatid segregation relationship: regulates GO:0000819 ! sister chromatid segregation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0033046 name: negative regulation of sister chromatid segregation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation." [GOC:mah] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0033045 ! regulation of sister chromatid segregation is_a: GO:0051985 ! negative regulation of chromosome segregation is_a: GO:2001251 ! negative regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0000819 ! sister chromatid segregation relationship: negatively_regulates GO:0000819 ! sister chromatid segregation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0033047 name: regulation of mitotic sister chromatid segregation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah] is_a: GO:0007088 ! regulation of mitotic nuclear division is_a: GO:0033045 ! regulation of sister chromatid segregation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0000070 ! mitotic sister chromatid segregation relationship: regulates GO:0000070 ! mitotic sister chromatid segregation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0033048 name: negative regulation of mitotic sister chromatid segregation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah] is_a: GO:0033046 ! negative regulation of sister chromatid segregation is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation is_a: GO:0045839 ! negative regulation of mitotic nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0000070 ! mitotic sister chromatid segregation relationship: negatively_regulates GO:0000070 ! mitotic sister chromatid segregation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0033059 name: cellular pigmentation namespace: biological_process def: "The deposition or aggregation of coloring matter in a cell." [GOC:mtg_MIT_16mar07] subset: gosubset_prok is_a: GO:0043473 ! pigmentation is_a: GO:0044763 ! single-organism cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0033216 name: ferric iron import namespace: biological_process def: "The directed movement of ferric iron (Fe(III) or Fe3+) ions into a cell or organelle." [GOC:mah] synonym: "ferric ion import" EXACT [] synonym: "ferric iron uptake" EXACT [] is_a: GO:0015682 ! ferric iron transport is_a: GO:0097286 ! iron ion import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0033218 name: amide binding namespace: molecular_function def: "Interacting selectively and non-covalently with an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [CHEBI:32988, GOC:mah] subset: goslim_pir is_a: GO:0005488 ! binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0033260 name: nuclear DNA replication namespace: biological_process def: "The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle." [GOC:mtg_cell_cycle] synonym: "DNA replication during S phase" RELATED [GOC:dph, GOC:tb] synonym: "DNA replication involved in S phase" EXACT [] synonym: "DNA replication involved in S-phase" EXACT [] synonym: "nuclear cell cycle DNA replication" EXACT [] is_a: GO:0044786 ! cell cycle DNA replication intersection_of: GO:0006260 ! DNA replication intersection_of: occurs_in GO:0005634 ! nucleus intersection_of: part_of GO:0007049 ! cell cycle relationship: occurs_in GO:0005634 ! nucleus relationship: part_of GO:0007049 ! cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0033262 name: regulation of nuclear cell cycle DNA replication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle." [GOC:mtg_cell_cycle] synonym: "regulation of DNA replication during S phase" RELATED [GOC:dph, GOC:tb] synonym: "regulation of DNA replication involved in S phase" EXACT [] synonym: "regulation of DNA replication involved in S-phase" EXACT [] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0090329 ! regulation of DNA-dependent DNA replication intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0033260 ! nuclear DNA replication relationship: regulates GO:0033260 ! nuclear DNA replication property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0033273 name: response to vitamin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus." [GOC:sl] is_a: GO:0007584 ! response to nutrient property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0033293 name: monocarboxylic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:mah] subset: gosubset_prok is_a: GO:0031406 ! carboxylic acid binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0033314 name: mitotic DNA replication checkpoint namespace: biological_process alt_id: GO:0031574 def: "A cell cycle checkpoint that acts during a mitotic cell cycle and prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:mtg_cell_cycle] synonym: "mitotic cell cycle DNA replication checkpoint" EXACT [] synonym: "S-M checkpoint" EXACT [] synonym: "S-M DNA replication checkpoint" EXACT [] synonym: "S-phase checkpoint" BROAD [] is_a: GO:0000076 ! DNA replication checkpoint is_a: GO:0044774 ! mitotic DNA integrity checkpoint is_a: GO:0044818 ! mitotic G2/M transition checkpoint intersection_of: GO:0000076 ! DNA replication checkpoint intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000278 ! mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0033365 name: protein localization to organelle namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within an organelle." [GOC:mah] synonym: "protein localisation to organelle" EXACT [GOC:mah] synonym: "protein localization in organelle" EXACT [GOC:mah] is_a: GO:0034613 ! cellular protein localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0033500 name: carbohydrate homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of an internal steady state of a carbohydrate within an organism or cell." [GOC:mah] subset: gosubset_prok is_a: GO:0048878 ! chemical homeostasis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0033523 name: histone H2B ubiquitination namespace: biological_process def: "The modification of histone H2B by addition of ubiquitin groups." [GOC:mah] is_a: GO:0016574 ! histone ubiquitination property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0033554 name: cellular response to stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0006950 ! response to stress is_a: GO:0051716 ! cellular response to stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0033558 name: protein deacetylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate." [GOC:mah] is_a: GO:0019213 ! deacetylase activity relationship: part_of GO:0006476 ! protein deacetylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0033566 name: gamma-tubulin complex localization namespace: biological_process def: "Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location." [GOC:mah] synonym: "establishment and maintenance of gamma-tubulin complex localization" EXACT [] synonym: "gamma-tubulin complex localisation" EXACT [GOC:mah] is_a: GO:0034629 ! cellular protein complex localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0033620 name: Mei2 nuclear dot complex namespace: cellular_component def: "A ribonucleoprotein complex that forms during meiotic prophase in a fixed position in the horsetail nucleus; contains Mei2 and meiRNA. May play a role in the progression of meiosis I." [GOC:vw, PMID:12808043] synonym: "Mei2 dot" EXACT [] synonym: "Mei2 nuclear dot" BROAD [] synonym: "nuclear body" RELATED [] is_a: GO:0030529 ! ribonucleoprotein complex is_a: GO:0044428 ! nuclear part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0033692 name: cellular polysaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of many (typically more than 10) monosaccharide residues linked glycosidically, occurring at the level of an individual cell." [CHEBI:18154, GOC:go_curators] subset: gosubset_prok synonym: "cellular glycan biosynthesis" EXACT [] synonym: "cellular glycan biosynthetic process" EXACT [] synonym: "cellular polysaccharide anabolism" EXACT [] synonym: "cellular polysaccharide biosynthesis" EXACT [] synonym: "cellular polysaccharide formation" EXACT [] synonym: "cellular polysaccharide synthesis" EXACT [] is_a: GO:0000271 ! polysaccharide biosynthetic process is_a: GO:0034637 ! cellular carbohydrate biosynthetic process is_a: GO:0034645 ! cellular macromolecule biosynthetic process is_a: GO:0044264 ! cellular polysaccharide metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0033699 name: DNA 5'-adenosine monophosphate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 5'-AMP-DNA + H2O = AMP + DNA; nucleophilic release of a covalently linked adenylate residue from a DNA strand, leaving a 5' phosphate terminus." [GOC:mah, PMID:16547001, PMID:17276982] synonym: "AMP-removal activity" RELATED [] synonym: "DNA 5'-adenylate hydrolase activity" EXACT [] synonym: "DNA adenylate hydrolysis activity" BROAD [] synonym: "DNA de-adenylation" RELATED [] synonym: "DNA deadenylation" RELATED [] is_a: GO:0035312 ! 5'-3' exodeoxyribonuclease activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0033892 name: deoxyribonuclease (pyrimidine dimer) activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate." [EC:3.1.25.1] synonym: "bacteriophage T4 endodeoxyribonuclease V activity" EXACT [EC:3.1.25.1] synonym: "endodeoxyribonuclease (pyrimidine dimer) activity" EXACT [EC:3.1.25.1] synonym: "T4 endonuclease V activity" EXACT [EC:3.1.25.1] xref: EC:3.1.25.1 xref: MetaCyc:3.1.25.1-RXN is_a: GO:0016890 ! site-specific endodeoxyribonuclease activity, specific for altered base property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0033979 name: box H/ACA snoRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving box H/ACA type small nucleolar RNA." [GOC:mah] is_a: GO:0016074 ! snoRNA metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034061 name: DNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:mah] subset: goslim_metagenomics subset: gosubset_prok synonym: "deoxynucleate polymerase activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleic acid polymerase activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleic polymerase activity" EXACT [EC:2.7.7.7] synonym: "DNA nucleotidyltransferase activity" EXACT [EC:2.7.7.7] xref: Reactome:REACT_115680 "Insertion of correct bases opposite to the lesion by Pol kappa, Gallus gallus" xref: Reactome:REACT_115778 "Elongation by Pol zeta complex, Gallus gallus" xref: Reactome:REACT_115899 "Elongation by Pol kappa, Gallus gallus" xref: Reactome:REACT_115932 "Insertion of correct bases opposite to the lesion by Pol eta, Gallus gallus" xref: Reactome:REACT_116106 "Repair of ~27-30 bp long patch by DNA Pol Epsilon, Gallus gallus" xref: Reactome:REACT_116167 "Elongation by Pol eta, Gallus gallus" is_a: GO:0016779 ! nucleotidyltransferase activity relationship: part_of GO:0071897 ! DNA biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034062 name: RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template." [EC:2.7.7.6, GOC:mah] subset: goslim_metagenomics subset: gosubset_prok synonym: "C ribonucleic acid formation factors" RELATED [EC:2.7.7.6] synonym: "C RNA formation factors" RELATED [EC:2.7.7.6] synonym: "ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.6] synonym: "ribonucleate polymerase activity" EXACT [EC:2.7.7.6] synonym: "ribonucleic acid nucleotidyltransferase" BROAD [EC:2.7.7.6] synonym: "ribonucleic acid polymerase activity" EXACT [EC:2.7.7.6] synonym: "ribonucleic acid transcriptase activity" EXACT [EC:2.7.7.6] synonym: "ribonucleic polymerase activity" EXACT [EC:2.7.7.6] synonym: "ribonucleic transcriptase activity" EXACT [EC:2.7.7.6] synonym: "RNA nucleotidyltransferase activity" EXACT [EC:2.7.7.6] synonym: "RNA transcriptase activity" EXACT [EC:2.7.7.6] synonym: "transcriptase" BROAD [EC:2.7.7.6] is_a: GO:0016779 ! nucleotidyltransferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034063 name: stress granule assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule." [GOC:mah, PMID:17392519] synonym: "SG assembly" EXACT [PMID:19825938] is_a: GO:0022618 ! ribonucleoprotein complex assembly is_a: GO:0070925 ! organelle assembly property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034067 name: protein localization to Golgi apparatus namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within the Golgi apparatus." [GOC:mah] synonym: "protein localisation in Golgi apparatus" EXACT [GOC:mah] synonym: "protein localization in Golgi apparatus" EXACT [GOC:curators] is_a: GO:0033365 ! protein localization to organelle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034080 name: CENP-A containing nucleosome assembly namespace: biological_process alt_id: GO:0034509 def: "The formation of nucleosomes containing the histone H3 variant CENP-A to form centromeric chromatin. This specialised chromatin occurs at centromeric region in point centromeres, and the central core in modular centromeres." [GOC:mah, GOC:vw, PMID:18158900, PMID:19217403] synonym: "CenH3-containing nucleosome assembly at centromere" RELATED [] synonym: "CENP-A containing nucleosome assembly at centromere" EXACT [GOC:vw] synonym: "CENP-A deposition" RELATED [GOC:vw] synonym: "CENP-A loading" RELATED [GOC:vw] synonym: "centromere specific nucleosome exchange" RELATED [GOC:mah] synonym: "centromere-specific histone exchange" EXACT [GOC:mah, GOC:vw] synonym: "centromeric DNA replication-independent nucleosome assembly" EXACT [GOC:mah] synonym: "DNA replication-independent nucleosome assembly at centromere" EXACT [GOC:mah] xref: Reactome:REACT_22186 "Deposition of New CENPA-containing Nucleosomes at the Centromere, Homo sapiens" is_a: GO:0006336 ! DNA replication-independent nucleosome assembly is_a: GO:0031055 ! chromatin remodeling at centromere is_a: GO:0043486 ! histone exchange relationship: has_part GO:0061644 ! protein localization to CENP-A containing chromatin relationship: part_of GO:0034508 ! centromere complex assembly relationship: part_of GO:0061641 ! CENP-A containing chromatin organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034212 name: peptide N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide." [GOC:mah] subset: gosubset_prok is_a: GO:0008080 ! N-acetyltransferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034219 name: carbohydrate transmembrane transport namespace: biological_process def: "The process in which a carbohydrate is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "carbohydrate membrane transport" EXACT [] synonym: "transmembrane carbohydrate transport" EXACT [GOC:dph, GOC:tb] is_a: GO:0008643 ! carbohydrate transport is_a: GO:0055085 ! transmembrane transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034220 name: ion transmembrane transport namespace: biological_process def: "A process in which an ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "ion membrane transport" EXACT [] synonym: "transmembrane ion transport" EXACT [GOC:dph, GOC:tb] xref: Reactome:REACT_100497 "Ion channel transport, Rattus norvegicus" xref: Reactome:REACT_101721 "Ion transport by P-type ATPases, Canis familiaris" xref: Reactome:REACT_103924 "Ion transport by P-type ATPases, Taeniopygia guttata" xref: Reactome:REACT_107347 "Ion channel transport, Caenorhabditis elegans" xref: Reactome:REACT_108844 "Ion transport by P-type ATPases, Drosophila melanogaster" xref: Reactome:REACT_109050 "Ion channel transport, Gallus gallus" xref: Reactome:REACT_25149 "Ion transport by P-type ATPases, Homo sapiens" xref: Reactome:REACT_25300 "Ion channel transport, Homo sapiens" xref: Reactome:REACT_25387 "Ligand-gated ion channel transport, Homo sapiens" xref: Reactome:REACT_28672 "Ion transport by P-type ATPases, Arabidopsis thaliana" xref: Reactome:REACT_30601 "Ion channel transport, Danio rerio" xref: Reactome:REACT_31166 "Ion channel transport, Sus scrofa" xref: Reactome:REACT_32763 "Ion channel transport, Plasmodium falciparum" xref: Reactome:REACT_33389 "Ion channel transport, Mycobacterium tuberculosis" xref: Reactome:REACT_34584 "Ion channel transport, Oryza sativa" xref: Reactome:REACT_77153 "Ion channel transport, Arabidopsis thaliana" xref: Reactome:REACT_77267 "Ion channel transport, Taeniopygia guttata" xref: Reactome:REACT_78982 "Ion transport by P-type ATPases, Bos taurus" xref: Reactome:REACT_79679 "Ion transport by P-type ATPases, Xenopus tropicalis" xref: Reactome:REACT_81685 "Ion channel transport, Bos taurus" xref: Reactome:REACT_82102 "Ion channel transport, Canis familiaris" xref: Reactome:REACT_89671 "Ion channel transport, Xenopus tropicalis" xref: Reactome:REACT_89674 "Ion transport by P-type ATPases, Caenorhabditis elegans" xref: Reactome:REACT_89758 "Ion transport by P-type ATPases, Sus scrofa" xref: Reactome:REACT_89890 "Ion transport by P-type ATPases, Oryza sativa" xref: Reactome:REACT_92146 "Ion transport by P-type ATPases, Mus musculus" xref: Reactome:REACT_93475 "Ion transport by P-type ATPases, Rattus norvegicus" xref: Reactome:REACT_94109 "Ion channel transport, Mus musculus" xref: Reactome:REACT_94939 "Ion transport by P-type ATPases, Mycobacterium tuberculosis" xref: Reactome:REACT_94986 "Ion transport by P-type ATPases, Plasmodium falciparum" xref: Reactome:REACT_97506 "Ion transport by P-type ATPases, Danio rerio" xref: Reactome:REACT_97619 "Ion channel transport, Drosophila melanogaster" xref: Reactome:REACT_98518 "Ion transport by P-type ATPases, Gallus gallus" is_a: GO:0006811 ! ion transport is_a: GO:0055085 ! transmembrane transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034224 name: cellular response to zinc ion starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of zinc ions." [GOC:mah] synonym: "cellular response to zinc ion limitation" EXACT [] synonym: "cellular response to zinc starvation" EXACT [] is_a: GO:0009267 ! cellular response to starvation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034226 name: lysine import namespace: biological_process def: "The directed movement of lysine, 2,6-diaminohexanoic acid, into a cell or organelle." [GOC:jl, GOC:mah] synonym: "L-lysine import" NARROW [] synonym: "lysine uptake" EXACT [] is_a: GO:0015819 ! lysine transport is_a: GO:0043090 ! amino acid import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034248 name: regulation of cellular amide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amides." [GOC:mah] synonym: "regulation of amide metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0043603 ! cellular amide metabolic process relationship: regulates GO:0043603 ! cellular amide metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034284 name: response to monosaccharide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus." [GOC:mah] synonym: "response to monosaccharide stimulus" EXACT [GOC:dos] is_a: GO:0009743 ! response to carbohydrate property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034293 name: sexual sporulation namespace: biological_process def: "The formation of spores derived from the products of meiosis." [GOC:mah] subset: goslim_aspergillus synonym: "meiotic spore formation" EXACT [] synonym: "meiotic sporulation" EXACT [] synonym: "sexual spore formation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0030435 ! sporulation resulting in formation of a cellular spore is_a: GO:0044702 ! single organism reproductive process is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0030435 ! sporulation resulting in formation of a cellular spore intersection_of: part_of GO:0051321 ! meiotic cell cycle relationship: part_of GO:0019953 ! sexual reproduction relationship: part_of GO:0051321 ! meiotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034353 name: RNA pyrophosphohydrolase activity namespace: molecular_function def: "Catalysis of the removal of a 5' terminal pyrophosphate from the 5'-triphosphate end of an RNA, leaving a 5'-monophosphate end." [GOC:jh2, PMID:17612492, PMID:18202662] is_a: GO:0016462 ! pyrophosphatase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034389 name: lipid particle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle." [GOC:dph, GOC:jl, GOC:mah, PMID:18093937, PMID:18250201] synonym: "adiposome organization" EXACT [] synonym: "lipid body organization" EXACT [] synonym: "lipid droplet organization" EXACT [] synonym: "lipid particle organisation" EXACT [GOC:curators] synonym: "lipid particle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034394 name: protein localization to cell surface namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane." [GOC:mah] synonym: "protein localisation at cell surface" EXACT [GOC:mah] synonym: "protein localization at cell surface" EXACT [GOC:curators] is_a: GO:0034613 ! cellular protein localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034397 name: telomere localization namespace: biological_process def: "Any process in which a telomere is transported to, and/or maintained in, a specific location." [GOC:mah, GOC:vw] synonym: "telomere localisation" EXACT [GOC:mah] is_a: GO:0050000 ! chromosome localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034398 name: telomere tethering at nuclear periphery namespace: biological_process def: "The process in which a telomere is maintained in a specific location at the nuclear periphery." [GOC:mah] is_a: GO:0034397 ! telomere localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034399 name: nuclear periphery namespace: cellular_component def: "The portion of the nuclear lumen proximal to the inner nuclear membrane." [GOC:krc, GOC:mah] is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031981 ! nuclear lumen property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034401 name: chromatin organization involved in regulation of transcription namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin that modulates the rate, frequency or extent of DNA-dependent transcription." [GOC:curators] subset: gocheck_do_not_manually_annotate synonym: "establishment or maintenance of chromatin architecture during transcription" EXACT [GOC:mah] synonym: "regulation of transcription by chromatin organisation" EXACT [GOC:mah] synonym: "regulation of transcription by chromatin organization" EXACT [] is_a: GO:0006325 ! chromatin organization intersection_of: GO:0006325 ! chromatin organization intersection_of: part_of GO:0006355 ! regulation of transcription, DNA-templated relationship: part_of GO:0006355 ! regulation of transcription, DNA-templated property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034428 name: nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3' namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occurs when the 5' end is not protected by a 5'-cap; degradation proceeds in the 5' to 3' direction." [GOC:krc, GOC:mah] synonym: "5'-3' exonucleolytic nuclear-transcribed mRNA catabolic process" EXACT [] is_a: GO:0000291 ! nuclear-transcribed mRNA catabolic process, exonucleolytic property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034431 name: bis(5'-adenosyl)-hexaphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: P1-P6-bis(5'-adenosyl) hexaphosphate + H2O = AMP + adenosine 5'-pentaphosphate." [PMID:10085096, PMID:9450008] synonym: "AP(6)A hydrolase activity" EXACT [] synonym: "AP-6-A hydrolase activity" EXACT [] synonym: "AP6A hydrolase activity" EXACT [] synonym: "diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase activity" EXACT [] is_a: GO:0004551 ! nucleotide diphosphatase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034453 name: microtubule anchoring namespace: biological_process def: "Any process in which a microtubule is maintained in a specific location in a cell." [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034470 name: ncRNA processing namespace: biological_process def: "Any process that results in the conversion of one or more primary non-coding RNA (ncRNA) transcripts into one or more mature ncRNA molecules." [GOC:mah] is_a: GO:0006396 ! RNA processing is_a: GO:0034660 ! ncRNA metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034471 name: ncRNA 5'-end processing namespace: biological_process def: "Any process involved in forming the mature 5' end of a non-coding RNA molecule." [GOC:mah] synonym: "ncRNA 5' end processing" EXACT [] is_a: GO:0000966 ! RNA 5'-end processing is_a: GO:0034470 ! ncRNA processing property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034472 name: snRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of an snRNA molecule." [GOC:mah] synonym: "snRNA 3' end processing" EXACT [] is_a: GO:0016180 ! snRNA processing is_a: GO:0043628 ! ncRNA 3'-end processing property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034486 name: vacuolar transmembrane transport namespace: biological_process def: "The process in which a solute is transported from one side of the vacuolar membrane to the other." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "vacuolar membrane transport" EXACT [] is_a: GO:0007034 ! vacuolar transport is_a: GO:0016482 ! cytoplasmic transport is_a: GO:0055085 ! transmembrane transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034497 name: protein localization to pre-autophagosomal structure namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, the pre-autophagosomal structure (PAS)." [GOC:rb] synonym: "protein localisation to pre-autophagosomal structure" EXACT [GOC:mah] synonym: "protein localization to PAS" EXACT [] is_a: GO:0034613 ! cellular protein localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034501 name: protein localization to kinetochore namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, the kinetochore." [GOC:mah] synonym: "condensin localization to kinetochore" NARROW [] synonym: "protein localisation to kinetochore" EXACT [GOC:mah] is_a: GO:0071459 ! protein localization to chromosome, centromeric region property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034502 name: protein localization to chromosome namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, a specific location on a chromosome." [GOC:mah] synonym: "condensin localization to chromosome" NARROW [] synonym: "protein localisation to chromosome" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034504 name: protein localization to nucleus namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within the nucleus." [GOC:ecd] synonym: "protein localisation to nucleus" EXACT [GOC:mah] synonym: "protein localization in cell nucleus" EXACT [] synonym: "protein localization in nucleus" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034508 name: centromere complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex. Includes the formation of the chromatin structures which form a platform for the kinetochore, and assembly of the kinetochore onto this specialized chromatin. In fission yeast and higher eukaryotes this process also includes the formation of heterochromatin at the outer repeat (pericentric) regions of the centromere." [GOC:mah, GOC:vw] synonym: "centromere assembly" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "centromere organization" EXACT [GOC:dph, PMID:18923422] synonym: "chromosome, centromeric region assembly" EXACT [GOC:pr] is_a: GO:0051276 ! chromosome organization is_a: GO:0065004 ! protein-DNA complex assembly property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034599 name: cellular response to oxidative stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] synonym: "adaptive response to oxidative stress" NARROW [GOC:add, GOC:vk] is_a: GO:0006979 ! response to oxidative stress is_a: GO:0033554 ! cellular response to stress is_a: GO:0070887 ! cellular response to chemical stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034605 name: cellular response to heat namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:mah] synonym: "cellular response to heat stress" EXACT [] is_a: GO:0009408 ! response to heat is_a: GO:0033554 ! cellular response to stress property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034613 name: cellular protein localization namespace: biological_process alt_id: GO:0016249 def: "Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] synonym: "cellular protein localisation" EXACT [GOC:mah] synonym: "channel localizer activity" NARROW [GOC:mah] is_a: GO:0008104 ! protein localization is_a: GO:0070727 ! cellular macromolecule localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034614 name: cellular response to reactive oxygen species namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:mah] subset: gosubset_prok synonym: "cellular response to active oxygen species" EXACT [] synonym: "cellular response to AOS" EXACT [] synonym: "cellular response to reactive oxidative species" EXACT [] synonym: "cellular response to reactive oxygen intermediate" EXACT [] synonym: "cellular response to ROI" EXACT [] synonym: "cellular response to ROS" EXACT [] is_a: GO:0000302 ! response to reactive oxygen species is_a: GO:0034599 ! cellular response to oxidative stress is_a: GO:1901701 ! cellular response to oxygen-containing compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034622 name: cellular macromolecular complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a complex, carried out at the cellular level." [GOC:mah] subset: goslim_pir subset: gosubset_prok synonym: "cellular macromolecule complex assembly" EXACT [] is_a: GO:0065003 ! macromolecular complex assembly property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034629 name: cellular protein complex localization namespace: biological_process def: "A protein complex localization process that takes place at the cellular level; as a result, a protein complex is transported to, or maintained in, a specific location within a cell." [GOC:mah] synonym: "cellular protein complex localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of cellular protein complex localization" EXACT [] is_a: GO:0031503 ! protein complex localization is_a: GO:0034613 ! cellular protein localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034631 name: microtubule anchoring at spindle pole body namespace: biological_process def: "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a spindle pole body. Microtubules attach to spindle pole bodies at the minus end." [GOC:mah, PMID:17486116] synonym: "attachment of spindle microtubules to SPB" EXACT [] synonym: "attachment of spindle microtubules to spindle pole body" EXACT [] synonym: "microtubule anchoring at SPB" EXACT [] is_a: GO:0022402 ! cell cycle process is_a: GO:0072393 ! microtubule anchoring at microtubule organizing center relationship: part_of GO:0007051 ! spindle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034637 name: cellular carbohydrate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, carried out by individual cells." [GOC:mah] is_a: GO:0016051 ! carbohydrate biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0044262 ! cellular carbohydrate metabolic process is_a: GO:0044763 ! single-organism cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034641 name: cellular nitrogen compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells." [GOC:mah] subset: goslim_chembl subset: goslim_generic subset: gosubset_prok synonym: "cellular nitrogen compound metabolism" EXACT [] xref: Reactome:REACT_102000 "Metabolism of amino acids and derivatives, Mycobacterium tuberculosis" xref: Reactome:REACT_103710 "Metabolism of amino acids and derivatives, Escherichia coli" xref: Reactome:REACT_107293 "Metabolism of amino acids and derivatives, Arabidopsis thaliana" xref: Reactome:REACT_108179 "Metabolism of amino acids and derivatives, Xenopus tropicalis" xref: Reactome:REACT_109042 "Metabolism of amino acids and derivatives, Sus scrofa" xref: Reactome:REACT_13 "Metabolism of amino acids and derivatives, Homo sapiens" xref: Reactome:REACT_28699 "Metabolism of amino acids and derivatives, Saccharomyces cerevisiae" xref: Reactome:REACT_29108 "Metabolism of amino acids and derivatives, Caenorhabditis elegans" xref: Reactome:REACT_32429 "Metabolism of amino acids and derivatives, Rattus norvegicus" xref: Reactome:REACT_33347 "Metabolism of amino acids and derivatives, Mus musculus" xref: Reactome:REACT_34326 "Metabolism of amino acids and derivatives, Staphylococcus aureus N315" xref: Reactome:REACT_55564 "Metabolism of amino acids and derivatives, Gallus gallus" xref: Reactome:REACT_77741 "Metabolism of amino acids and derivatives, Taeniopygia guttata" xref: Reactome:REACT_82379 "Metabolism of amino acids and derivatives, Bos taurus" xref: Reactome:REACT_86268 "Metabolism of amino acids and derivatives, Drosophila melanogaster" xref: Reactome:REACT_90299 "Metabolism of amino acids and derivatives, Oryza sativa" xref: Reactome:REACT_91959 "Metabolism of amino acids and derivatives, Plasmodium falciparum" xref: Reactome:REACT_93580 "Metabolism of amino acids and derivatives, Danio rerio" xref: Reactome:REACT_95666 "Metabolism of amino acids and derivatives, Canis familiaris" xref: Reactome:REACT_98086 "Metabolism of amino acids and derivatives, Dictyostelium discoideum" xref: Reactome:REACT_99241 "Metabolism of amino acids and derivatives, Schizosaccharomyces pombe" is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0044237 ! cellular metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034644 name: cellular response to UV namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:mah] subset: gosubset_prok synonym: "cellular response to ultraviolet light stimulus" EXACT [] synonym: "cellular response to ultraviolet radiation stimulus" EXACT [] synonym: "cellular response to UV light stimulus" EXACT [] synonym: "cellular response to UV radiation stimulus" EXACT [] is_a: GO:0009411 ! response to UV is_a: GO:0071482 ! cellular response to light stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034645 name: cellular macromolecule biosynthetic process namespace: biological_process alt_id: GO:0034961 def: "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells." [CHEBI:33694, GOC:mah] synonym: "cellular biopolymer biosynthetic process" EXACT [GOC:mtg_chebi_dec09] synonym: "cellular macromolecule anabolism" EXACT [GOC:mah] synonym: "cellular macromolecule biosynthesis" EXACT [GOC:mah] synonym: "cellular macromolecule formation" EXACT [GOC:mah] synonym: "cellular macromolecule synthesis" EXACT [GOC:mah] is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0044260 ! cellular macromolecule metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034654 name: nucleobase-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] subset: gosubset_prok synonym: "nucleobase, nucleoside, nucleotide and nucleic acid anabolism" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid biosynthesis" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid formation" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid synthesis" NARROW [] is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034655 name: nucleobase-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:mah] subset: goslim_chembl subset: goslim_generic subset: gosubset_prok synonym: "nucleobase, nucleoside, nucleotide and nucleic acid breakdown" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid catabolic process" RELATED [GOC:dph, GOC:tb] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid catabolism" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid degradation" EXACT [] is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034660 name: ncRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving non-coding RNA transcripts (ncRNAs)." [GOC:mah] subset: gosubset_prok synonym: "ncRNA metabolism" EXACT [] xref: Reactome:REACT_104424 "Metabolism of non-coding RNA, Sus scrofa" xref: Reactome:REACT_107260 "Metabolism of non-coding RNA, Canis familiaris" xref: Reactome:REACT_11052 "Metabolism of non-coding RNA, Homo sapiens" xref: Reactome:REACT_31743 "Metabolism of non-coding RNA, Rattus norvegicus" xref: Reactome:REACT_34395 "Metabolism of non-coding RNA, Taeniopygia guttata" xref: Reactome:REACT_77416 "Metabolism of non-coding RNA, Gallus gallus" xref: Reactome:REACT_82057 "Metabolism of non-coding RNA, Drosophila melanogaster" xref: Reactome:REACT_87487 "Metabolism of non-coding RNA, Danio rerio" xref: Reactome:REACT_91823 "Metabolism of non-coding RNA, Xenopus tropicalis" xref: Reactome:REACT_92649 "Metabolism of non-coding RNA, Bos taurus" xref: Reactome:REACT_94145 "Metabolism of non-coding RNA, Mus musculus" is_a: GO:0016070 ! RNA metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034724 name: DNA replication-independent nucleosome organization namespace: biological_process def: "The formation or destruction of chromatin structures, occurring outside the context of DNA replication." [GOC:mah, PMID:17510629] synonym: "DNA replication-independent nucleosome organisation" EXACT [GOC:curators] is_a: GO:0006333 ! chromatin assembly or disassembly is_a: GO:0034728 ! nucleosome organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034728 name: nucleosome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of one or more nucleosomes." [GOC:mah] synonym: "nucleosome organisation" EXACT [GOC:curators] is_a: GO:0006325 ! chromatin organization is_a: GO:0071822 ! protein complex subunit organization is_a: GO:0071824 ! protein-DNA complex subunit organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034770 name: histone H4-K20 methylation namespace: biological_process def: "The modification of histone H4 by addition of one or more methyl groups to lysine at position 20 of the histone." [GOC:mah] synonym: "histone H4 K20 methylation" EXACT [] synonym: "histone H4K20me" EXACT [] synonym: "histone lysine H4 K20 methylation" EXACT [] is_a: GO:0034968 ! histone lysine methylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034771 name: histone H4-K20 monomethylation namespace: biological_process def: "The modification of histone H4 by addition of one methyl group to lysine at position 20 of the histone." [GOC:mah] synonym: "histone H4 K20 monomethylation" EXACT [] synonym: "histone lysine H4 K20 monomethylation" EXACT [] is_a: GO:0018026 ! peptidyl-lysine monomethylation is_a: GO:0034770 ! histone H4-K20 methylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034772 name: histone H4-K20 dimethylation namespace: biological_process def: "The modification of histone H4 by addition of two methyl groups to lysine at position 20 of the histone." [GOC:mah] synonym: "histone H4 K20 dimethylation" EXACT [] synonym: "histone lysine H4 K20 dimethylation" EXACT [] is_a: GO:0018027 ! peptidyl-lysine dimethylation is_a: GO:0034770 ! histone H4-K20 methylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034773 name: histone H4-K20 trimethylation namespace: biological_process def: "The modification of histone H4 by addition of three methyl groups to lysine at position 20 of the histone." [GOC:mah] synonym: "histone H4 K20 trimethylation" EXACT [] synonym: "histone lysine H4 K20 trimethylation" EXACT [] is_a: GO:0018023 ! peptidyl-lysine trimethylation is_a: GO:0034770 ! histone H4-K20 methylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034964 name: box H/ACA snoRNA processing namespace: biological_process def: "Any process involved in the conversion of a primary box H/ACA type small nucleolar RNA (snoRNA) transcript into a mature box H/ACA snoRNA." [GOC:mah] is_a: GO:0033979 ! box H/ACA snoRNA metabolic process is_a: GO:0043144 ! snoRNA processing property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034968 name: histone lysine methylation namespace: biological_process def: "The modification of a histone by addition of a methyl group to a lysine residue." [GOC:mah] is_a: GO:0016571 ! histone methylation is_a: GO:0018022 ! peptidyl-lysine methylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0034976 name: response to endoplasmic reticulum stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:cjm, GOC:mah] synonym: "cellular response to endoplasmic reticulum stress" EXACT [] synonym: "ER stress response" EXACT [] synonym: "response to ER stress" EXACT [] is_a: GO:0033554 ! cellular response to stress property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0035064 name: methylated histone binding namespace: molecular_function def: "Interacting selectively and non-covalently with a histone protein in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes." [GOC:bf, PMID:14585615] is_a: GO:0042393 ! histone binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0035251 name: UDP-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a glucosyl group from UDP-glucose to an acceptor molecule." [http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/polysacc/UDPsugar.html] subset: gosubset_prok xref: MetaCyc:PHENOL-BETA-GLUCOSYLTRANSFERASE-RXN is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0046527 ! glucosyltransferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0035312 name: 5'-3' exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule." [ISBN:0198547684] is_a: GO:0008409 ! 5'-3' exonuclease activity is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0035372 name: protein localization to microtubule namespace: biological_process def: "A process in which a protein is transported to, or maintained at, a microtubule." [GOC:bf, GOC:lb] synonym: "protein localisation to microtubule" EXACT [GOC:mah] is_a: GO:0072698 ! protein localization to microtubule cytoskeleton property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2010-03-11T11:00:56Z [Term] id: GO:0035404 name: histone-serine phosphorylation namespace: biological_process def: "The modification of histones by addition of a phosphate group to a serine residue." [GOC:bf] synonym: "histone serine phosphorylation" EXACT [] is_a: GO:0016572 ! histone phosphorylation is_a: GO:0018105 ! peptidyl-serine phosphorylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2010-03-24T10:08:25Z [Term] id: GO:0035444 name: nickel cation transmembrane transport namespace: biological_process def: "The directed movement of nickel (Ni) cations across a membrane by means of some agent such as a transporter or pore." [GOC:vw] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "nickel cation membrane transport" EXACT [] is_a: GO:0015675 ! nickel cation transport is_a: GO:0098662 ! inorganic cation transmembrane transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2010-04-13T09:22:51Z [Term] id: GO:0035556 name: intracellular signal transduction namespace: biological_process alt_id: GO:0007242 alt_id: GO:0007243 alt_id: GO:0023013 alt_id: GO:0023034 def: "The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] synonym: "intracellular protein kinase cascade" NARROW [GOC:signaling] synonym: "intracellular signal transduction pathway" NARROW [] synonym: "intracellular signaling cascade" RELATED [GOC:signaling] synonym: "intracellular signaling chain" EXACT [ISBN:3527303782] synonym: "intracellular signaling pathway" RELATED [] synonym: "protein kinase cascade" NARROW [GOC:signaling] synonym: "signal transduction via intracellular signaling cascade" RELATED [] synonym: "signal transmission via intracellular cascade" NARROW [] xref: Reactome:REACT_100795 "PKA-mediated phosphorylation of key metabolic factors, Saccharomyces cerevisiae" xref: Reactome:REACT_102462 "PKA-mediated phosphorylation of key metabolic factors, Canis familiaris" xref: Reactome:REACT_104200 "PKA-mediated phosphorylation of key metabolic factors, Taeniopygia guttata" xref: Reactome:REACT_108216 "PKA-mediated phosphorylation of key metabolic factors, Dictyostelium discoideum" xref: Reactome:REACT_1525 "PKA-mediated phosphorylation of key metabolic factors, Homo sapiens" xref: Reactome:REACT_80030 "PKA-mediated phosphorylation of key metabolic factors, Sus scrofa" xref: Reactome:REACT_83068 "PKA-mediated phosphorylation of key metabolic factors, Gallus gallus" xref: Reactome:REACT_83869 "PKA-mediated phosphorylation of key metabolic factors, Xenopus tropicalis" xref: Reactome:REACT_87453 "PKA-mediated phosphorylation of key metabolic factors, Bos taurus" xref: Reactome:REACT_89085 "PKA-mediated phosphorylation of key metabolic factors, Rattus norvegicus" xref: Reactome:REACT_89983 "PKA-mediated phosphorylation of key metabolic factors, Danio rerio" xref: Reactome:REACT_90740 "PKA-mediated phosphorylation of key metabolic factors, Schizosaccharomyces pombe" xref: Reactome:REACT_99938 "PKA-mediated phosphorylation of key metabolic factors, Mus musculus" is_a: GO:0007165 ! signal transduction intersection_of: GO:0007165 ! signal transduction intersection_of: occurs_in GO:0005622 ! intracellular relationship: occurs_in GO:0005622 ! intracellular property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2010-05-14T01:14:37Z [Term] id: GO:0035601 name: protein deacylation namespace: biological_process def: "The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a protein amino acid." [GOC:se, PMID:12080046] synonym: "protein amino acid deacylation" EXACT [GOC:se] is_a: GO:0006464 ! cellular protein modification process is_a: GO:0098732 ! macromolecule deacylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2010-11-15T11:06:15Z [Term] id: GO:0035617 name: stress granule disassembly namespace: biological_process def: "The disaggregation of a stress granule into its constituent protein and RNA parts." [GOC:BHF, PMID:19825938] synonym: "SG disassembly" EXACT [PMID:19825938] is_a: GO:0032988 ! ribonucleoprotein complex disassembly is_a: GO:1903008 ! organelle disassembly property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2010-12-03T10:38:57Z [Term] id: GO:0035639 name: purine ribonucleoside triphosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [CHEBI:26398, GOC:BHF, GOC:ebc, ISBN:0198506732] synonym: "purine NTP binding" BROAD [GOC:ebc] is_a: GO:0043168 ! anion binding is_a: GO:1901265 ! nucleoside phosphate binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2011-01-14T02:46:42Z [Term] id: GO:0035725 name: sodium ion transmembrane transport namespace: biological_process def: "A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:vw] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "sodium ion membrane transport" EXACT [] is_a: GO:0006814 ! sodium ion transport is_a: GO:0098662 ! inorganic cation transmembrane transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2011-03-10T02:52:36Z [Term] id: GO:0035770 name: ribonucleoprotein granule namespace: cellular_component def: "A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions." [GOC:go_curators, GOC:sp, PMID:16520386, PMID:20368989, PMID:21436445] synonym: "mRNP granule" EXACT [] synonym: "RNA granule" NARROW [] synonym: "RNP granule" EXACT [] is_a: GO:0030529 ! ribonucleoprotein complex is_a: GO:0043232 ! intracellular non-membrane-bounded organelle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2011-04-01T10:50:47Z [Term] id: GO:0035822 name: gene conversion namespace: biological_process def: "A DNA recombination process that results in the unidirectional transfer of genetic material from a donor sequence to a highly homologous acceptor." [GOC:mah, PMID:17846636] is_a: GO:0006310 ! DNA recombination property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2011-05-04T01:04:39Z [Term] id: GO:0035824 name: long tract gene conversion namespace: biological_process def: "A gene conversion process in which a segment of more than 1000 base pairs is transferred from the donor to the acceptor." [GOC:mah, PMID:16954385] is_a: GO:0035822 ! gene conversion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2011-05-04T01:06:18Z [Term] id: GO:0035825 name: reciprocal DNA recombination namespace: biological_process def: "A DNA recombination process that results in the equal exchange of genetic material between the recombining DNA molecules." [GOC:mah, PMID:11139492, PMID:17304215] synonym: "chromosomal crossover" EXACT [GOC:mah, Wikipedia:Chromosomal_crossover] xref: Wikipedia:Chromosomal_crossover is_a: GO:0006310 ! DNA recombination property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2011-05-04T01:23:31Z [Term] id: GO:0035838 name: growing cell tip namespace: cellular_component def: "The region at either end of the longest axis of a cylindrical or elongated cell, where polarized growth occurs." [GOC:mah] synonym: "growing cell end" EXACT [GOC:mah] is_a: GO:0030427 ! site of polarized growth is_a: GO:0051286 ! cell tip property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2011-05-06T01:28:44Z [Term] id: GO:0035861 name: site of double-strand break namespace: cellular_component def: "A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix." [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408] synonym: "DNA damage foci" RELATED [GOC:vw] synonym: "DNA damage focus" RELATED [GOC:mah, PMID:20096808, PMID:21035408] synonym: "ionizing radiation-induced foci" RELATED [PMID:20096808, PMID:21035408] synonym: "IRIF" RELATED [PMID:20096808, PMID:21035408] synonym: "site of DSB" EXACT [PMID:21035408] is_a: GO:0044427 ! chromosomal part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2011-05-17T03:04:42Z [Term] id: GO:0035874 name: cellular response to copper ion starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of copper ions." [GOC:vw, PMID:16467469] synonym: "cellular response to copper starvation" EXACT [GOC:bf] is_a: GO:0009267 ! cellular response to starvation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2011-05-31T09:28:47Z [Term] id: GO:0035939 name: microsatellite binding namespace: molecular_function def: "Interacting selectively and non-covalently with a microsatellite, a repeat_region in DNA containing repeat units (2 to 4 base pairs) that is repeated multiple times in tandem." [GOC:yaf, PMID:21290414, SO:0000289] synonym: "microsatellite DNA binding" EXACT [GOC:bf] synonym: "variable number tandem repeat binding" EXACT [PMID:21290414] synonym: "VNTR binding" EXACT [SO:0000289] is_a: GO:0003696 ! satellite DNA binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2011-07-20T01:26:26Z [Term] id: GO:0035974 name: meiotic spindle pole body namespace: cellular_component def: "The microtubule organizing center on a spindle that forms as part of meiosis; functionally homologous to the animal cell centrosome." [GOC:vw, PMID:21775631] is_a: GO:0005816 ! spindle pole body relationship: part_of GO:0072687 ! meiotic spindle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2011-08-16T11:37:59Z [Term] id: GO:0036078 name: minus-end specific microtubule depolymerization namespace: biological_process def: "The removal of tubulin heterodimers from the minus end of a microtubule." [GOC:sart, PMID:17452528] is_a: GO:0007019 ! microtubule depolymerization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2011-12-19T03:20:25Z [Term] id: GO:0036094 name: small molecule binding namespace: molecular_function def: "Interacting selectively and non-covalently with a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm] comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. is_a: GO:0005488 ! binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2012-01-17T04:20:34Z [Term] id: GO:0036123 name: histone H3-K9 dimethylation namespace: biological_process def: "The modification of histone H3 by addition of two methyl groups to lysine at position 9 of the histone." [GOC:vw] synonym: "histone H3 K9 dimethylation" EXACT [] synonym: "histone lysine H3 K9 dimethylation" EXACT [] is_a: GO:0018027 ! peptidyl-lysine dimethylation is_a: GO:0051567 ! histone H3-K9 methylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2012-02-20T03:06:15Z [Term] id: GO:0036124 name: histone H3-K9 trimethylation namespace: biological_process def: "The modification of histone H3 by addition of three methyl groups to lysine at position 9 of the histone." [GOC:vw] is_a: GO:0018023 ! peptidyl-lysine trimethylation is_a: GO:0051567 ! histone H3-K9 methylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2012-02-20T03:08:06Z [Term] id: GO:0036181 name: protein localization to linear element namespace: biological_process def: "A cellular protein localization process in which a protein is transported to, or maintained at, a linear element. A linear element is a proteinaceous scaffold associated with S. pombe chromosomes during meiotic prophase." [GOC:mah, PMID:19756689] synonym: "protein localisation to linear element" EXACT [GOC:mah] is_a: GO:1903084 ! protein localization to condensed nuclear chromosome property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2012-03-30T04:14:17Z [Term] id: GO:0036211 name: protein modification process namespace: biological_process def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl] synonym: "protein modification" EXACT [GOC:bf] is_a: GO:0019538 ! protein metabolic process is_a: GO:0043412 ! macromolecule modification property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2012-04-26T01:47:12Z [Term] id: GO:0036213 name: contractile ring contraction namespace: biological_process def: "The process of an actomyosin ring getting smaller in diameter." [GOC:mah, GOC:vw] comment: This term can be used to annotate contraction of either bacterial or fungal contractile rings. is_a: GO:0032506 ! cytokinetic process relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2012-04-26T02:58:18Z [Term] id: GO:0036214 name: contractile ring localization namespace: biological_process def: "The process in which a contractile ring is assembled and/or maintained in a specific location." [GOC:mah, GOC:vw] comment: This term can be used to annotate localization of either bacterial or fungal contractile rings. is_a: GO:0032506 ! cytokinetic process relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2012-04-26T02:58:50Z [Term] id: GO:0036223 name: cellular response to adenine starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of adenine." [CHEBI:16708, GOC:ai] synonym: "cellular response to adenine deprivation" EXACT [GOC:bf] is_a: GO:0009267 ! cellular response to starvation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2012-05-09T02:26:52Z [Term] id: GO:0036225 name: cellular response to vitamin B1 starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of vitamin B1 (also called thiamin and thiamine)." [CHEBI:18385, GOC:al] synonym: "cellular response to thiamin starvation" EXACT [CHEBI:18385, Wikipedia:Thiamine] synonym: "cellular response to vitamin B1 deprivation" EXACT [GOC:bf] is_a: GO:0009267 ! cellular response to starvation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2012-05-09T02:35:55Z [Term] id: GO:0036226 name: mitotic cell cycle arrest in response to glucose starvation namespace: biological_process def: "The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of deprivation of glucose." [GOC:al, GOC:mah, PMID:958201] synonym: "cell cycle arrest in response to glucose starvation" BROAD [] is_a: GO:0042149 ! cellular response to glucose starvation is_a: GO:0071850 ! mitotic cell cycle arrest property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2012-05-09T02:43:22Z [Term] id: GO:0036227 name: mitotic G2 cell cycle arrest in response to glucose starvation namespace: biological_process def: "The process in which the mitotic cell cycle is halted during G2 phase as a result of deprivation of glucose." [GOC:al, GOC:mah, GOC:mtg_cell_cycle, PMID:958201] is_a: GO:0036226 ! mitotic cell cycle arrest in response to glucose starvation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2012-05-09T02:45:49Z [Term] id: GO:0036229 name: L-glutamine import namespace: biological_process def: "The directed movement of L-glutamine, the L-enantiomer of glutamine, into a cell or organelle." [CHEBI:18050, GOC:al] synonym: "L-glutamine uptake" EXACT [GOC:bf] is_a: GO:0006868 ! glutamine transport is_a: GO:0043092 ! L-amino acid import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2012-05-11T10:46:21Z [Term] id: GO:0036231 name: L-threonine import namespace: biological_process def: "The directed movement of L-threonine, the L-enantiomer of threonine, into a cell or organelle." [CHEBI:16857, GOC:al] synonym: "L-threonine uptake" EXACT [GOC:bf] is_a: GO:0015826 ! threonine transport is_a: GO:0043092 ! L-amino acid import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2012-05-11T10:46:21Z [Term] id: GO:0036232 name: L-tyrosine import namespace: biological_process def: "The directed movement of L-tyrosine, the L-enantiomer of tyrosine, into a cell or organelle." [CHEBI:17895, GOC:al] synonym: "L-tyrosine uptake" EXACT [GOC:bf] is_a: GO:0015828 ! tyrosine transport is_a: GO:0043092 ! L-amino acid import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2012-05-11T10:46:21Z [Term] id: GO:0036233 name: glycine import namespace: biological_process def: "The directed movement of glycine into a cell or organelle." [GOC:al] is_a: GO:0015816 ! glycine transport is_a: GO:0043092 ! L-amino acid import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2012-05-11T01:16:45Z [Term] id: GO:0036245 name: cellular response to menadione namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menadione stimulus. Menadione (also called vitamin K3) is a naphthoquinone having a methyl substituent at the 2-position." [CHEBI:28869, GOC:al] synonym: "cellular response to vitamin K3" EXACT [CHEBI:28869, GOC:al, Wikipedia:Menadione] is_a: GO:0071310 ! cellular response to organic substance is_a: GO:1901655 ! cellular response to ketone property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2012-05-28T10:23:02Z [Term] id: GO:0036249 name: cadmium ion import into vacuole namespace: biological_process def: "The directed movement of cadmium ions into the vacuole." [GOC:al] synonym: "vacuolar cadmium import" RELATED [GOC:bf] is_a: GO:0034486 ! vacuolar transmembrane transport is_a: GO:0070574 ! cadmium ion transmembrane transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2012-05-31T11:13:44Z [Term] id: GO:0036260 name: RNA capping namespace: biological_process def: "The sequence of enzymatic reactions by which a cap structure is added to the 5' end of a nascent RNA polymerase II transcript. All RNA polymerase II transcripts receive a 7-methyl-G cap. Then for (at least) small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs), the7-methyl-G cap is hypermethylated to become a 2,2,7-trimethylguanosine (TMG) cap." [GOC:bf, GOC:krc, GOC:mah, PMID:18775984] is_a: GO:0006396 ! RNA processing property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2012-06-15T02:10:23Z [Term] id: GO:0036261 name: 7-methylguanosine cap hypermethylation namespace: biological_process def: "Hypermethylation of the 7-(mono)methylguanosine (m(7)G) cap structure at the 2' position of the guanosine residue to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. This type of cap modification occurs on small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs) and is dependent on prior guanine-N7 methylation." [GOC:bf, GOC:BHF, GOC:krc, GOC:mah, GOC:rl, PMID:11983179, PMID:18775984] synonym: "2,2,7-trimethylguanosine cap formation" EXACT [PMID:11983179] synonym: "conversion of m(7)G to m(3)G" EXACT [PMID:11983179] synonym: "hypermethylation of snoRNA cap" NARROW [GOC:bf, GOC:krc, GOC:mah] synonym: "hypermethylation of snRNA cap" NARROW [GOC:bf, GOC:krc, GOC:mah] synonym: "m(7)G cap hypermethylation" EXACT [GOC:bf] synonym: "snoRNA capping" NARROW [GOC:rl] synonym: "snRNA capping" NARROW [GOC:rl] synonym: "TMG cap formation" EXACT [PMID:11983179] is_a: GO:0001510 ! RNA methylation is_a: GO:0036260 ! RNA capping property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2012-06-15T02:21:39Z [Term] id: GO:0036285 name: SAGA complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a SAGA complex, a SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof." [GOC:mah, PMID:10637607, PMID:22456315] synonym: "SAGA complex formation" EXACT [GOC:bf] is_a: GO:0043623 ! cellular protein complex assembly property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2012-07-16T10:30:00Z [Term] id: GO:0036286 name: eisosome filament namespace: cellular_component def: "A filamentous cortical structure formed, in S. pombe, by the eisosome component Pil1." [GOC:vw, PMID:21900489, PMID:23722945] synonym: "linear eisosome" EXACT [GOC:vw] is_a: GO:0043234 ! protein complex is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044448 ! cell cortex part relationship: part_of GO:0030863 ! cortical cytoskeleton relationship: part_of GO:0032126 ! eisosome property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2012-07-16T10:52:24Z [Term] id: GO:0036293 name: response to decreased oxygen levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen." [GOC:al] comment: This term should be used when a decrease in oxygen levels is not considered a stress response. For a hypoxic stress response, consider instead 'response to hypoxia ; GO:0001666'. synonym: "response to lowered oxygen levels" EXACT [GOC:bf] is_a: GO:0070482 ! response to oxygen levels property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2012-07-20T01:05:46Z [Term] id: GO:0036294 name: cellular response to decreased oxygen levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen." [GOC:al] comment: This term should be used when a decrease in oxygen levels is not considered a stress response. For a hypoxic stress response, consider instead 'cellular response to hypoxia ; GO:0071456'. synonym: "cellular response to lowered oxygen levels" EXACT [GOC:bf] is_a: GO:0036293 ! response to decreased oxygen levels is_a: GO:0071453 ! cellular response to oxygen levels property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2012-07-20T01:08:40Z [Term] id: GO:0036349 name: galactose-specific flocculation namespace: biological_process def: "The non-sexual aggregation of single-celled organisms mediated by the binding of cell wall proteins on one cell to galactose residues on the other." [GOC:vw, PMID:22098069] is_a: GO:0000501 ! flocculation via cell wall protein-carbohydrate interaction relationship: has_part GO:0005534 ! galactose binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2012-09-19T10:56:16Z [Term] id: GO:0036350 name: mannose-specific flocculation namespace: biological_process def: "The non-sexual aggregation of single-celled organisms mediated by the binding of cell wall proteins on one cell to mannose residues on the other." [GOC:vw, PMID:9851992] is_a: GO:0000501 ! flocculation via cell wall protein-carbohydrate interaction relationship: has_part GO:0005537 ! mannose binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2012-09-19T10:57:34Z [Term] id: GO:0036387 name: pre-replicative complex namespace: cellular_component def: "A protein-DNA complex that forms at the origin of replication during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication." [GOC:bf, GOC:bhm, GOC:jh2, Wikipedia:Pre-replication_complex] comment: This term describes pre-replicative complexes across organisms. synonym: "pre-RC" EXACT [Wikipedia:Pre-replication_complex] synonym: "pre-replication complex" EXACT [Wikipedia:Pre-replication_complex] is_a: GO:0032993 ! protein-DNA complex property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2013-06-05T16:14:52Z [Term] id: GO:0036388 name: pre-replicative complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the pre-replicative complex, a protein-DNA complex that forms at the origin of replication during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication." [GOC:bf, GOC:bhm, GOC:jh2] synonym: "pre-RC assembly" EXACT [Wikipedia:Pre-replication_complex] synonym: "pre-replication complex assembly" RELATED [Wikipedia:Pre-replication_complex] is_a: GO:0065004 ! protein-DNA complex assembly relationship: part_of GO:0006261 ! DNA-dependent DNA replication property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2013-06-05T16:29:13Z [Term] id: GO:0036440 name: citrate synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA." [RHEA:16848] xref: KEGG:R00351 xref: RHEA:16848 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2013-09-30T16:21:50Z [Term] id: GO:0036450 name: polyuridylation-dependent decapping of nuclear-transcribed mRNA namespace: biological_process def: "Cleavage of the 5'-cap of a nuclear-transcribed mRNA that has been modified by the enzymatic addition of a sequence of uridylyl residues (polyuridylation) at the 3' end." [GOC:vw, PMID:19430462] synonym: "uridylation-dependent decapping of nuclear-transcribed mRNA" BROAD [GOC:vw] is_a: GO:0031087 ! deadenylation-independent decapping of nuclear-transcribed mRNA relationship: part_of GO:1990074 ! polyuridylation-dependent mRNA catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2013-11-04T11:37:28Z [Term] id: GO:0036459 name: ubiquitinyl hydrolase activity namespace: molecular_function def: "Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin." [EC:3.4.19.12, GOC:bf, GOC:ka] synonym: "ubiquitin C-terminal hydrolase" EXACT [EC:3.4.19.12] synonym: "ubiquitinyl hydrolase 1 activity" EXACT [EC:3.4.19.12] is_a: GO:0016787 ! hydrolase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rfoulger creation_date: 2013-12-19T09:39:38Z [Term] id: GO:0036464 name: cytoplasmic ribonucleoprotein granule namespace: cellular_component def: "A ribonucleoprotein granule located in the cytoplasm." [GOC:bf, GOC:PARL, PMID:15121898] synonym: "Staufen granule" NARROW [PMID:15121898] is_a: GO:0035770 ! ribonucleoprotein granule is_a: GO:0044444 ! cytoplasmic part intersection_of: GO:0035770 ! ribonucleoprotein granule intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005737 ! cytoplasm property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rebeccafoulger creation_date: 2014-06-18T09:44:44Z [Term] id: GO:0036503 name: ERAD pathway namespace: biological_process def: "The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:bf, GOC:PARL] synonym: "endoplasmic reticulum-associated degradation" EXACT [PMID:22535891] synonym: "endoplasmic reticulum-associated protein degradation pathway" RELATED [GOC:bf] synonym: "ER-associated degradation pathway" RELATED [PMID:24699081] synonym: "protein degradation by ERAD" EXACT [GOC:bf] is_a: GO:0010033 ! response to organic substance is_a: GO:0030163 ! protein catabolic process is_a: GO:0034976 ! response to endoplasmic reticulum stress is_a: GO:0044712 ! single-organism catabolic process is_a: GO:0044763 ! single-organism cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rebeccafoulger creation_date: 2015-05-14T11:43:06Z [Term] id: GO:0040007 name: growth namespace: biological_process alt_id: GO:0048590 def: "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma] comment: See also the biological process term 'cell growth ; GO:0016049'. subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "growth pattern" RELATED [] synonym: "non-developmental growth" RELATED [GOC:mah] is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0040008 name: regulation of growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah] subset: gosubset_prok is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0040007 ! growth relationship: regulates GO:0040007 ! growth property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0040023 name: establishment of nucleus localization namespace: biological_process def: "The directed movement of the nucleus to a specific location within a cell." [GOC:ai] subset: goslim_aspergillus synonym: "establishment of cell nucleus localization" EXACT [] synonym: "establishment of localization of nucleus" EXACT [] synonym: "establishment of nucleus localisation" EXACT [GOC:mah] synonym: "establishment of position of nucleus" EXACT [] synonym: "nuclear positioning" EXACT [] synonym: "nucleus positioning" EXACT [] synonym: "positioning of nucleus" EXACT [] is_a: GO:0051647 ! nucleus localization is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0040029 name: regulation of gene expression, epigenetic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence." [PMID:10521337, PMID:11498582] subset: goslim_plant subset: gosubset_prok is_a: GO:0010468 ! regulation of gene expression property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0040031 name: snRNA modification namespace: biological_process def: "The covalent alteration of one or more nucleotides within snRNA, resulting in a change in the properties of the snRNA." [GOC:jl] is_a: GO:0009451 ! RNA modification is_a: GO:0016073 ! snRNA metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042054 name: histone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue." [EC:2.1.1.43] synonym: "histone methylase activity" EXACT [GOC:mah] is_a: GO:0008276 ! protein methyltransferase activity relationship: part_of GO:0016571 ! histone methylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042138 name: meiotic DNA double-strand break formation namespace: biological_process def: "The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination." [GOC:elh, GOC:jl, PMID:11529427] is_a: GO:0044710 ! single-organism metabolic process is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0007127 ! meiosis I property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042144 name: vacuole fusion, non-autophagic namespace: biological_process alt_id: GO:0042145 def: "The fusion of two vacuole membranes to form a single vacuole." [GOC:jl] synonym: "homotypic vacuole fusion" EXACT [] synonym: "homotypic vacuole fusion (non-autophagic)" EXACT [] synonym: "homotypic vacuole fusion, non-autophagic" EXACT [] synonym: "vacuole fusion (non-autophagic)" EXACT [] is_a: GO:0044801 ! single-organism membrane fusion is_a: GO:0097576 ! vacuole fusion is_a: GO:1902589 ! single-organism organelle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042149 name: cellular response to glucose starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose." [GOC:jl] is_a: GO:0009267 ! cellular response to starvation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042157 name: lipoprotein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [ISBN:0198506732] subset: gosubset_prok synonym: "lipoprotein metabolism" EXACT [] xref: Reactome:REACT_101960 "apolipoprotein(a) + LDL => Lp(a), Gallus gallus" xref: Reactome:REACT_102413 "HDL-mediated lipid transport, Caenorhabditis elegans" xref: Reactome:REACT_102496 "Chylomicron-mediated lipid transport, Sus scrofa" xref: Reactome:REACT_103493 "Chylomicron-mediated lipid transport, Taeniopygia guttata" xref: Reactome:REACT_105868 "Chylomicron-mediated lipid transport, Mus musculus" xref: Reactome:REACT_107056 "Lipoprotein metabolism, Oryza sativa" xref: Reactome:REACT_110247 "HDL-mediated lipid transport, Danio rerio" xref: Reactome:REACT_110573 "Lipoprotein metabolism, Taeniopygia guttata" xref: Reactome:REACT_112911 "apolipoprotein(a) + LDL => Lp(a), Xenopus tropicalis" xref: Reactome:REACT_13621 "HDL-mediated lipid transport, Homo sapiens" xref: Reactome:REACT_28841 "Lipoprotein metabolism, Drosophila melanogaster" xref: Reactome:REACT_29288 "Chylomicron-mediated lipid transport, Rattus norvegicus" xref: Reactome:REACT_33886 "HDL-mediated lipid transport, Arabidopsis thaliana" xref: Reactome:REACT_59602 "Lipoprotein metabolism, Rattus norvegicus" xref: Reactome:REACT_6823 "Lipoprotein metabolism, Homo sapiens" xref: Reactome:REACT_6841 "Chylomicron-mediated lipid transport, Homo sapiens" xref: Reactome:REACT_6958 "apolipoprotein(a) + LDL => Lp(a), Homo sapiens" xref: Reactome:REACT_73884 "HDL-mediated lipid transport, Canis familiaris" xref: Reactome:REACT_78284 "apolipoprotein(a) + LDL => Lp(a), Rattus norvegicus" xref: Reactome:REACT_79032 "HDL-mediated lipid transport, Xenopus tropicalis" xref: Reactome:REACT_79044 "HDL-mediated lipid transport, Mus musculus" xref: Reactome:REACT_79237 "Lipoprotein metabolism, Arabidopsis thaliana" xref: Reactome:REACT_80334 "HDL-mediated lipid transport, Gallus gallus" xref: Reactome:REACT_80616 "apolipoprotein(a) + LDL => Lp(a), Mus musculus" xref: Reactome:REACT_82187 "Lipoprotein metabolism, Sus scrofa" xref: Reactome:REACT_82188 "Lipoprotein metabolism, Bos taurus" xref: Reactome:REACT_82533 "Chylomicron-mediated lipid transport, Gallus gallus" xref: Reactome:REACT_83113 "HDL-mediated lipid transport, Bos taurus" xref: Reactome:REACT_83971 "HDL-mediated lipid transport, Drosophila melanogaster" xref: Reactome:REACT_84211 "HDL-mediated lipid transport, Sus scrofa" xref: Reactome:REACT_84712 "Lipoprotein metabolism, Danio rerio" xref: Reactome:REACT_85446 "Chylomicron-mediated lipid transport, Danio rerio" xref: Reactome:REACT_85688 "Lipoprotein metabolism, Canis familiaris" xref: Reactome:REACT_85772 "HDL-mediated lipid transport, Taeniopygia guttata" xref: Reactome:REACT_85867 "apolipoprotein(a) + LDL => Lp(a), Taeniopygia guttata" xref: Reactome:REACT_86142 "Lipoprotein metabolism, Xenopus tropicalis" xref: Reactome:REACT_87119 "Chylomicron-mediated lipid transport, Canis familiaris" xref: Reactome:REACT_88173 "Lipoprotein metabolism, Mus musculus" xref: Reactome:REACT_88824 "Lipoprotein metabolism, Plasmodium falciparum" xref: Reactome:REACT_90523 "apolipoprotein(a) + LDL => Lp(a), Danio rerio" xref: Reactome:REACT_90792 "HDL-mediated lipid transport, Oryza sativa" xref: Reactome:REACT_91134 "Lipoprotein metabolism, Gallus gallus" xref: Reactome:REACT_91166 "apolipoprotein(a) + LDL => Lp(a), Sus scrofa" xref: Reactome:REACT_92373 "apolipoprotein(a) + LDL => Lp(a), Bos taurus" xref: Reactome:REACT_92731 "apolipoprotein(a) + LDL => Lp(a), Canis familiaris" xref: Reactome:REACT_93774 "HDL-mediated lipid transport, Rattus norvegicus" xref: Reactome:REACT_96211 "HDL-mediated lipid transport, Plasmodium falciparum" xref: Reactome:REACT_96602 "Chylomicron-mediated lipid transport, Bos taurus" xref: Reactome:REACT_97927 "Lipoprotein metabolism, Caenorhabditis elegans" xref: Reactome:REACT_98591 "Chylomicron-mediated lipid transport, Xenopus tropicalis" is_a: GO:0019538 ! protein metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042158 name: lipoprotein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [ISBN:0198506732] subset: gosubset_prok synonym: "lipoprotein anabolism" EXACT [] synonym: "lipoprotein biosynthesis" EXACT [] synonym: "lipoprotein formation" EXACT [] synonym: "lipoprotein synthesis" EXACT [] xref: Reactome:REACT_100834 "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular], Mus musculus" xref: Reactome:REACT_101820 "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular], Bos taurus" xref: Reactome:REACT_103581 "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular], Gallus gallus" xref: Reactome:REACT_107441 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex, Danio rerio" xref: Reactome:REACT_110066 "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron, Canis familiaris" xref: Reactome:REACT_30241 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex, Rattus norvegicus" xref: Reactome:REACT_30451 "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron, Mus musculus" xref: Reactome:REACT_31956 "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron, Bos taurus" xref: Reactome:REACT_34229 "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular], Canis familiaris" xref: Reactome:REACT_6813 "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular], Homo sapiens" xref: Reactome:REACT_6908 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex, Homo sapiens" xref: Reactome:REACT_6915 "ApoB-48:TG:PL complex + 100 triacylglycerols + ApoA-I + ApoA-IV => nascent chylomicron, Homo sapiens" xref: Reactome:REACT_79155 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex, Canis familiaris" xref: Reactome:REACT_81934 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex, Xenopus tropicalis" xref: Reactome:REACT_84235 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex, Mus musculus" xref: Reactome:REACT_89204 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex, Gallus gallus" xref: Reactome:REACT_93001 "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular], Xenopus tropicalis" xref: Reactome:REACT_95479 "nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular], Sus scrofa" xref: Reactome:REACT_95856 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex, Bos taurus" xref: Reactome:REACT_98397 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex, Taeniopygia guttata" is_a: GO:0034645 ! cellular macromolecule biosynthetic process is_a: GO:0042157 ! lipoprotein metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042175 name: nuclear outer membrane-endoplasmic reticulum membrane network namespace: cellular_component def: "The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane." [GOC:bf, GOC:jl, GOC:mah, GOC:mcc, GOC:pr, GOC:vw] synonym: "NE-ER continuum" RELATED [] synonym: "NE-ER network" RELATED [] synonym: "nuclear envelope-endoplasmic reticulum continuum" RELATED [] synonym: "nuclear envelope-endoplasmic reticulum network" RELATED [GOC:mah] synonym: "nuclear envelope-ER network" RELATED [] synonym: "nuclear membrane-endoplasmic reticulum continuum" EXACT [GOC:mah] synonym: "nuclear membrane-ER network" EXACT [GOC:mah] is_a: GO:0016020 ! membrane is_a: GO:0044464 ! cell part relationship: part_of GO:0012505 ! endomembrane system property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042176 name: regulation of protein catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl] subset: gosubset_prok synonym: "regulation of protein breakdown" EXACT [] synonym: "regulation of protein catabolism" EXACT [] synonym: "regulation of protein degradation" EXACT [] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0030163 ! protein catabolic process relationship: regulates GO:0030163 ! protein catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042177 name: negative regulation of protein catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl, PMID:10207076] subset: gosubset_prok synonym: "down regulation of protein catabolic process" EXACT [] synonym: "down-regulation of protein catabolic process" EXACT [] synonym: "downregulation of protein catabolic process" EXACT [] synonym: "inhibition of protein catabolic process" NARROW [] synonym: "negative regulation of protein breakdown" EXACT [] synonym: "negative regulation of protein catabolism" EXACT [] synonym: "negative regulation of protein degradation" EXACT [] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0042176 ! regulation of protein catabolic process is_a: GO:0051248 ! negative regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0030163 ! protein catabolic process relationship: negatively_regulates GO:0030163 ! protein catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042180 name: cellular ketone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:jl, ISBN:0787650153] subset: goslim_pir subset: gosubset_prok synonym: "ketone metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0044763 ! single-organism cellular process is_a: GO:0071704 ! organic substance metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042182 name: ketone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:go_curators] subset: gosubset_prok synonym: "ketone breakdown" EXACT [] synonym: "ketone catabolism" EXACT [] synonym: "ketone degradation" EXACT [] is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:0044282 ! small molecule catabolic process is_a: GO:1901575 ! organic substance catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042221 name: response to chemical namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_yeast subset: gosubset_prok synonym: "response to chemical stimulus" EXACT [GOC:dos] synonym: "response to chemical substance" EXACT [] is_a: GO:0050896 ! response to stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042244 name: spore wall assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a spore wall; a spore wall is the specialized envelope lying outside the cell membrane of a spore." [GOC:mah, GOC:pg] subset: gosubset_prok synonym: "spore coat biosynthesis" EXACT [] synonym: "spore coat biosynthetic process" EXACT [] synonym: "spore wall formation" EXACT [] is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0070726 ! cell wall assembly relationship: part_of GO:0070590 ! spore wall biogenesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042254 name: ribosome biogenesis namespace: biological_process alt_id: GO:0007046 def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: gosubset_prok synonym: "ribosomal chaperone activity" RELATED [] synonym: "ribosome biogenesis and assembly" EXACT [] xref: Wikipedia:Ribosome_biogenesis is_a: GO:0022613 ! ribonucleoprotein complex biogenesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042276 name: error-prone translesion synthesis namespace: biological_process def: "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites." [GOC:elh, GOC:jl, PMID:11485998] subset: gosubset_prok synonym: "error-prone postreplication DNA repair" RELATED [GOC:elh] synonym: "mutagenic postreplication DNA repair" RELATED [GOC:elh] synonym: "mutagenic PRR" EXACT [] is_a: GO:0019985 ! translesion synthesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042277 name: peptide binding namespace: molecular_function def: "Interacting selectively and non-covalently with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds." [GOC:jl] subset: goslim_chembl subset: goslim_pir subset: gosubset_prok is_a: GO:0033218 ! amide binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042278 name: purine nucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713] subset: gosubset_prok synonym: "purine metabolic process" BROAD [] synonym: "purine metabolism" BROAD [] synonym: "purine nucleoside metabolism" EXACT [] is_a: GO:0009116 ! nucleoside metabolic process is_a: GO:0072521 ! purine-containing compound metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042325 name: regulation of phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl] subset: gosubset_prok is_a: GO:0019220 ! regulation of phosphate metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016310 ! phosphorylation relationship: regulates GO:0016310 ! phosphorylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042393 name: histone binding namespace: molecular_function def: "Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity." [GOC:jl] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "histone-specific chaperone activity" RELATED [] is_a: GO:0005515 ! protein binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042398 name: cellular modified amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents." [CHEBI:83821, GOC:ai] subset: gosubset_prok synonym: "amino acid derivative biosynthetic process" EXACT [GOC:curators] synonym: "cellular amino acid derivative anabolism" EXACT [] synonym: "cellular amino acid derivative biosynthesis" EXACT [] synonym: "cellular amino acid derivative biosynthetic process" EXACT [GOC:curators] synonym: "cellular amino acid derivative formation" EXACT [] synonym: "cellular amino acid derivative synthesis" EXACT [] synonym: "cellular modified amino acid anabolism" EXACT [GOC:mah] synonym: "cellular modified amino acid biosynthesis" EXACT [GOC:mah] synonym: "cellular modified amino acid formation" EXACT [GOC:mah] synonym: "cellular modified amino acid synthesis" EXACT [GOC:mah] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042451 name: purine nucleoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:go_curators] subset: gosubset_prok synonym: "purine nucleoside anabolism" EXACT [] synonym: "purine nucleoside biosynthesis" EXACT [] synonym: "purine nucleoside formation" EXACT [] synonym: "purine nucleoside synthesis" EXACT [] is_a: GO:0009163 ! nucleoside biosynthetic process is_a: GO:0042278 ! purine nucleoside metabolic process is_a: GO:0072522 ! purine-containing compound biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042455 name: ribonucleoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [CHEBI:18254, GOC:jl] subset: gosubset_prok synonym: "ribonucleoside anabolism" EXACT [] synonym: "ribonucleoside biosynthesis" EXACT [] synonym: "ribonucleoside formation" EXACT [] synonym: "ribonucleoside synthesis" EXACT [] is_a: GO:0009119 ! ribonucleoside metabolic process is_a: GO:0009163 ! nucleoside biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042539 name: hypotonic salinity response namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl] synonym: "response to hypotonic salt stress" EXACT [] is_a: GO:0006971 ! hypotonic response is_a: GO:0009651 ! response to salt stress property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042542 name: response to hydrogen peroxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:jl] subset: gosubset_prok is_a: GO:0000302 ! response to reactive oxygen species is_a: GO:0010035 ! response to inorganic substance property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042546 name: cell wall biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall. Includes biosynthesis of constituent macromolecules, such as proteins and polysaccharides, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. A cell wall is the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:jl, GOC:mah, GOC:mtg_sensu, ISBN:0198506732] subset: gosubset_prok synonym: "cell wall assembly" NARROW [] is_a: GO:0044085 ! cellular component biogenesis is_a: GO:0071554 ! cell wall organization or biogenesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042555 name: MCM complex namespace: cellular_component def: "A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021] synonym: "mini-chromosome maintenance complex" EXACT [] is_a: GO:0043234 ! protein complex relationship: has_part GO:0097373 ! MCM core complex property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042578 name: phosphoric ester hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3." [GOC:jl] subset: gosubset_prok xref: EC:3.1.-.- is_a: GO:0016788 ! hydrolase activity, acting on ester bonds property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042579 name: microbody namespace: cellular_component def: "Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2)." [ISBN:0198506732] subset: goslim_pir xref: Wikipedia:Microbody is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042592 name: homeostatic process namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state." [GOC:jl, ISBN:0395825172] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: gosubset_prok synonym: "homeostasis" RELATED [] is_a: GO:0065008 ! regulation of biological quality property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042593 name: glucose homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators] subset: gosubset_prok is_a: GO:0033500 ! carbohydrate homeostasis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042594 name: response to starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators] subset: goslim_yeast subset: gosubset_prok is_a: GO:0006950 ! response to stress is_a: GO:0031667 ! response to nutrient levels property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042623 name: ATPase activity, coupled namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl] subset: gosubset_prok synonym: "ATP phosphohydrolase (polypeptide-unfolding)" NARROW [EC:3.6.4.9] synonym: "chaperonin" RELATED [EC:3.6.4.9] synonym: "chaperonin ATPase activity" RELATED [] synonym: "non-chaperonin molecular chaperone ATPase activity" RELATED [] synonym: "nucleoplasmin ATPase activity" RELATED [] synonym: "peroxisome-assembly ATPase activity" RELATED [] is_a: GO:0016887 ! ATPase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042625 name: ATPase activity, coupled to transmembrane movement of ions namespace: molecular_function def: "Catalysis of the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate." [EC:3.6.1.3, GOC:jl, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok is_a: GO:0015075 ! ion transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042626 name: ATPase activity, coupled to transmembrane movement of substances namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl] subset: gosubset_prok synonym: "ABC transporter" NARROW [] synonym: "ABC-type efflux permease activity" NARROW [] synonym: "ABC-type efflux porter activity" NARROW [] synonym: "ABC-type uptake permease activity" NARROW [] synonym: "ATP binding cassette transporter" NARROW [] synonym: "ATP-binding cassette (ABC) transporter activity" NARROW [] synonym: "ATP-binding cassette transporter" NARROW [] synonym: "mating pheromone exporter" NARROW [] xref: Reactome:REACT_111189 "ABCA4 mediates retinal transport, Homo sapiens" xref: Reactome:REACT_118120 "ABCC1 mediates LTC4 export from the cell, Schizosaccharomyces pombe" xref: Reactome:REACT_118121 "ABCC1 mediates LTC4 export from the cell, Rattus norvegicus" xref: Reactome:REACT_118141 "ABCC1 mediates LTC4 export from the cell, Canis familiaris" xref: Reactome:REACT_118269 "ABCC1 mediates LTC4 export from the cell, Sus scrofa" xref: Reactome:REACT_118294 "ABCC1 mediates LTC4 export from the cell, Danio rerio" xref: Reactome:REACT_118298 "ABCC1 mediates LTC4 export from the cell, Taeniopygia guttata" xref: Reactome:REACT_118340 "ABCC1 mediates LTC4 export from the cell, Saccharomyces cerevisiae" xref: Reactome:REACT_118343 "ABCC1 mediates LTC4 export from the cell, Gallus gallus" xref: Reactome:REACT_118360 "ABCC1 mediates LTC4 export from the cell, Xenopus tropicalis" xref: Reactome:REACT_118361 "ABCC1 mediates LTC4 export from the cell, Bos taurus" xref: Reactome:REACT_118365 "ABCC1 mediates LTC4 export from the cell, Dictyostelium discoideum" xref: Reactome:REACT_118397 "ABCC1 mediates LTC4 export from the cell, Caenorhabditis elegans" xref: Reactome:REACT_118433 "ABCC1 mediates LTC4 export from the cell, Mus musculus" xref: Reactome:REACT_15474 "ABCC1 mediates LTC4 export from the cell, Homo sapiens" is_a: GO:0015405 ! P-P-bond-hydrolysis-driven transmembrane transporter activity is_a: GO:0016820 ! hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances is_a: GO:0043492 ! ATPase activity, coupled to movement of substances property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042631 name: cellular response to water deprivation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of water." [GOC:go_curators] synonym: "cellular response to drought" EXACT [] is_a: GO:0009414 ! response to water deprivation is_a: GO:0031668 ! cellular response to extracellular stimulus is_a: GO:0033554 ! cellular response to stress is_a: GO:0071462 ! cellular response to water stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042645 name: mitochondrial nucleoid namespace: cellular_component def: "The region of a mitochondrion to which the DNA is confined." [GOC:jl] is_a: GO:0009295 ! nucleoid is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044429 ! mitochondrial part intersection_of: GO:0009295 ! nucleoid intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005759 ! mitochondrial matrix property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042710 name: biofilm formation namespace: biological_process def: "A process in which planktonically growing microorganisms grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:di, PMID:11932229] subset: gocheck_do_not_annotate subset: gocheck_do_not_manually_annotate subset: goslim_candida subset: goslim_pir subset: gosubset_prok is_a: GO:0044764 ! multi-organism cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042743 name: hydrogen peroxide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:jl, http://biotech.icmb.utexas.edu/] subset: gosubset_prok synonym: "H2O2 metabolic process" EXACT [GOC:mah] synonym: "hydrogen peroxide metabolism" EXACT [] is_a: GO:0072593 ! reactive oxygen species metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042744 name: hydrogen peroxide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl] subset: gosubset_prok synonym: "detoxification of H2O2" RELATED [GOC:vw] synonym: "detoxification of hydrogen peroxide" RELATED [GOC:vw] synonym: "H2O2 catabolic process" EXACT [GOC:mah] synonym: "H2O2 scavenging" RELATED [GOC:vw] synonym: "hydrogen peroxide breakdown" EXACT [] synonym: "hydrogen peroxide catabolism" EXACT [] synonym: "hydrogen peroxide degradation" EXACT [] synonym: "hydrogen peroxide removal" RELATED [] synonym: "hydrogen peroxide scavenging" RELATED [GOC:vw] is_a: GO:0042743 ! hydrogen peroxide metabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:0044712 ! single-organism catabolic process is_a: GO:0044763 ! single-organism cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042763 name: intracellular immature spore namespace: cellular_component def: "A cell or part of the cell that constitutes an early developmental stage of a spore, a small reproductive body that is highly resistant to desiccation and heat and is capable of growing into a new organism, produced especially by certain bacteria, fungi, algae, and nonflowering plants." [GOC:jl, ISBN:0395825172] subset: gosubset_prok synonym: "forespore" RELATED [] is_a: GO:0044464 ! cell part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042764 name: ascospore-type prospore namespace: cellular_component def: "An immature spore undergoing development. The spore usually consists of nucleic acid, prospore membrane(s) that encase the nucleic acid, and ultimately a cell wall that covers the membrane(s). This type of spore is observed in ascospore-forming fungi." [GOC:go_curators] is_a: GO:0042763 ! intracellular immature spore property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042773 name: ATP synthesis coupled electron transport namespace: biological_process def: "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP." [ISBN:0716731363] subset: gosubset_prok is_a: GO:0022904 ! respiratory electron transport chain relationship: part_of GO:0006119 ! oxidative phosphorylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042775 name: mitochondrial ATP synthesis coupled electron transport namespace: biological_process def: "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane." [GOC:mtg_sensu, ISBN:0716731363] synonym: "mitochondrial electron transport" BROAD [] synonym: "organelle ATP synthesis coupled electron transport" BROAD [] is_a: GO:0042773 ! ATP synthesis coupled electron transport intersection_of: GO:0042773 ! ATP synthesis coupled electron transport intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042780 name: tRNA 3'-end processing namespace: biological_process def: "The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA." [GOC:go_curators] subset: gosubset_prok synonym: "tRNA 3' processing" EXACT [] is_a: GO:0008033 ! tRNA processing is_a: GO:0043628 ! ncRNA 3'-end processing property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042800 name: histone methyltransferase activity (H3-K4 specific) namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein." [PMID:12086618] comment: Note that in some species, the methyl group may be added to a lysine in a slightly different position of the histone H3 protein, but that this term still applies. synonym: "histone H3 lysine 4-specific methyltransferase activity" EXACT [] synonym: "histone lysine N-methyltransferase activity (H3-K4 specific)" EXACT [] synonym: "histone methylase activity (H3-K4 specific)" EXACT [GOC:mah] xref: Reactome:REACT_27174 "Prdm9 Trimethylates Histone H3 (murine, bovine), Bos taurus" xref: Reactome:REACT_27242 "Trimethylation of Histone H3 by PRDM9, Homo sapiens" xref: Reactome:REACT_27263 "Prdm9 Trimethylates Histone H3 at Lysine-4, Mus musculus" is_a: GO:0018024 ! histone-lysine N-methyltransferase activity relationship: part_of GO:0051568 ! histone H3-K4 methylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042814 name: monopolar cell growth namespace: biological_process def: "Polarized growth from one end of a cell." [GOC:vw] synonym: "monopolar cell elongation" NARROW [] synonym: "monopolar growth" BROAD [] synonym: "polar cell elongation" NARROW [] is_a: GO:0009826 ! unidimensional cell growth property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042815 name: bipolar cell growth namespace: biological_process def: "The process in which a cell irreversibly increases in size along one axis through simultaneous polarized growth from opposite ends of a cell, resulting in morphogenesis of the cell." [GOC:vw] comment: Bipolar cell growth refers to a change in both cell size and cell shape. For shape changes where cell size is not affected, consider instead the term 'establishment or maintenance of bipolar cell polarity resulting in cell shape ; GO:0061246' and its children. synonym: "bipolar cell elongation" NARROW [] synonym: "bipolar growth" BROAD [] synonym: "polar cell elongation" RELATED [] is_a: GO:0009826 ! unidimensional cell growth property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042822 name: pyridoxal phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl, http://www.mercksource.com/] subset: gosubset_prok synonym: "active vitamin B6 metabolic process" EXACT [] synonym: "active vitamin B6 metabolism" EXACT [] synonym: "pyridoxal phosphate metabolism" EXACT [] is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:0051186 ! cofactor metabolic process is_a: GO:0072524 ! pyridine-containing compound metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042823 name: pyridoxal phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl, http://www.mercksource.com/] subset: gosubset_prok synonym: "active vitamin B6 biosynthesis" EXACT [] synonym: "active vitamin B6 biosynthetic process" EXACT [] synonym: "pyridoxal phosphate anabolism" EXACT [] synonym: "pyridoxal phosphate biosynthesis" EXACT [] synonym: "pyridoxal phosphate formation" EXACT [] synonym: "pyridoxal phosphate synthesis" EXACT [] xref: MetaCyc:PWY0-845 is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0042822 ! pyridoxal phosphate metabolic process is_a: GO:0046184 ! aldehyde biosynthetic process is_a: GO:0072525 ! pyridine-containing compound biosynthetic process is_a: GO:0090407 ! organophosphate biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042868 name: antisense RNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis." [GOC:jl] subset: gosubset_prok synonym: "antisense RNA metabolism" EXACT [] is_a: GO:0034660 ! ncRNA metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042886 name: amide transport namespace: biological_process def: "The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732] subset: goslim_pir subset: gosubset_prok is_a: GO:0044765 ! single-organism transport is_a: GO:0071705 ! nitrogen compound transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0042995 name: cell projection namespace: cellular_component def: "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, http://www.cogsci.princeton.edu/~wn/] subset: goslim_pir subset: gosubset_prok synonym: "cell process" BROAD [] synonym: "cellular process" BROAD [] synonym: "cellular projection" EXACT [] is_a: GO:0044464 ! cell part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043007 name: maintenance of rDNA namespace: biological_process def: "Any process involved in sustaining the fidelity and copy number of rDNA repeats." [GOC:vw, PMID:14528010] synonym: "rDNA maintenance" EXACT [] synonym: "ribosomal DNA maintenance" EXACT [] is_a: GO:0043570 ! maintenance of DNA repeat elements property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043021 name: ribonucleoprotein complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with any complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk] subset: goslim_pir subset: gosubset_prok synonym: "protein-RNA complex binding" EXACT [GOC:bf, GOC:vk] synonym: "ribonucleoprotein binding" EXACT [GOC:bf, GOC:vk] synonym: "RNP binding" EXACT [] is_a: GO:0044877 ! macromolecular complex binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043022 name: ribosome binding namespace: molecular_function alt_id: GO:0030376 def: "Interacting selectively and non-covalently with any part of a ribosome." [GOC:go_curators] subset: gosubset_prok synonym: "ribosome receptor activity" NARROW [] is_a: GO:0043021 ! ribonucleoprotein complex binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043043 name: peptide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide." [CHEBI:16670, GOC:dph, GOC:jl] subset: gosubset_prok synonym: "peptide anabolism" EXACT [] synonym: "peptide biosynthesis" EXACT [] synonym: "peptide formation" EXACT [] synonym: "peptide synthesis" EXACT [] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043044 name: ATP-dependent chromatin remodeling namespace: biological_process def: "Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors." [GOC:jl, PMID:12042764] synonym: "ATP-dependent chromatin remodelling" EXACT [] is_a: GO:0006338 ! chromatin remodeling property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043060 name: meiotic metaphase I plate congression namespace: biological_process def: "The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis I." [GOC:cab1, PMID:10809666] is_a: GO:0051311 ! meiotic metaphase plate congression relationship: part_of GO:0045143 ! homologous chromosome segregation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043085 name: positive regulation of catalytic activity namespace: biological_process def: "Any process that activates or increases the activity of an enzyme." [GOC:jl, GOC:tb] subset: goslim_chembl subset: gosubset_prok synonym: "activation of enzyme activity" NARROW [] synonym: "positive regulation of enzyme activity" EXACT [GOC:tb] synonym: "stimulation of enzyme activity" NARROW [] synonym: "up regulation of enzyme activity" EXACT [] synonym: "up-regulation of enzyme activity" EXACT [] synonym: "upregulation of enzyme activity" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0044093 ! positive regulation of molecular function is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0003824 ! catalytic activity relationship: positively_regulates GO:0003824 ! catalytic activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043086 name: negative regulation of catalytic activity namespace: biological_process def: "Any process that stops or reduces the activity of an enzyme." [GOC:jl, GOC:tb] subset: gosubset_prok synonym: "down regulation of enzyme activity" EXACT [] synonym: "down-regulation of enzyme activity" EXACT [] synonym: "downregulation of enzyme activity" EXACT [] synonym: "inhibition of enzyme activity" NARROW [] synonym: "negative regulation of enzyme activity" EXACT [GOC:tb] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0003824 ! catalytic activity relationship: negatively_regulates GO:0003824 ! catalytic activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043090 name: amino acid import namespace: biological_process def: "The directed movement of amino acids into a cell or organelle." [GOC:jl] subset: gosubset_prok synonym: "amino acid uptake" EXACT [] is_a: GO:0006865 ! amino acid transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043091 name: L-arginine import namespace: biological_process def: "The directed movement of L-arginine, the L-enantiomer of 2-amino-5-guanidinopentanoic acid, into a cell or organelle." [GOC:jl, GOC:jsg, GOC:mah] synonym: "L-arginine uptake" EXACT [] is_a: GO:0043092 ! L-amino acid import is_a: GO:0090467 ! arginine import is_a: GO:1902023 ! L-arginine transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043092 name: L-amino acid import namespace: biological_process def: "The directed movement of L-enantiomer amino acids into a cell or organelle." [GOC:jl, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "L-amino acid uptake" EXACT [] is_a: GO:0015807 ! L-amino acid transport is_a: GO:0043090 ! amino acid import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043111 name: replication fork arrest namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork." [GOC:jl, PMID:14645529] comment: See also the biological process term 'site-specific replication termination ; GO:0071170' and its children. subset: gosubset_prok synonym: "negative regulation of DNA replication at replication fork barrier" EXACT [GOC:dph, GOC:tb] synonym: "replication fork blocking" EXACT [] synonym: "replication fork stalling" EXACT [] is_a: GO:0045005 ! DNA-dependent DNA replication maintenance of fidelity is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043138 name: 3'-5' DNA helicase activity namespace: molecular_function def: "Catalysis of the unwinding of the DNA helix in the direction 3' to 5'." [GOC:jl] synonym: "3' to 5' DNA helicase activity" EXACT [] is_a: GO:0003678 ! DNA helicase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043139 name: 5'-3' DNA helicase activity namespace: molecular_function def: "Catalysis of the unwinding of the DNA helix in the direction 5' to 3'." [GOC:jl] synonym: "5' to 3' DNA helicase activity" EXACT [] is_a: GO:0003678 ! DNA helicase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043140 name: ATP-dependent 3'-5' DNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'." [GOC:jl] synonym: "ATP-dependent 3' to 5' DNA helicase activity" EXACT [] is_a: GO:0004003 ! ATP-dependent DNA helicase activity is_a: GO:0043138 ! 3'-5' DNA helicase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043141 name: ATP-dependent 5'-3' DNA helicase activity namespace: molecular_function alt_id: GO:0008722 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 5' to 3'." [GOC:jl] synonym: "ATP-dependent 5' to 3' DNA helicase activity" EXACT [] synonym: "DNA helicase IV activity" NARROW [] xref: EC:3.6.1.- is_a: GO:0004003 ! ATP-dependent DNA helicase activity is_a: GO:0043139 ! 5'-3' DNA helicase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043144 name: snoRNA processing namespace: biological_process def: "Any process involved in the conversion of a primary small nucleolar RNA (snoRNA) transcript into a mature snoRNA." [GOC:go_curators, PMID:12773397] subset: goslim_yeast is_a: GO:0016074 ! snoRNA metabolic process is_a: GO:0034470 ! ncRNA processing property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043161 name: proteasome-mediated ubiquitin-dependent protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators] synonym: "proteasomal pathway" EXACT [] synonym: "proteasomal processing" RELATED [] synonym: "proteasomal ubiquitin-dependent protein breakdown" EXACT [] synonym: "proteasomal ubiquitin-dependent protein catabolic process" EXACT [] synonym: "proteasomal ubiquitin-dependent protein catabolism" EXACT [] synonym: "proteasomal ubiquitin-dependent protein degradation" EXACT [] synonym: "proteasome pathway" RELATED [] xref: Reactome:REACT_103814 "Degradation multiubiquitinated Cyclin A, Xenopus tropicalis" xref: Reactome:REACT_6937 "Degradation multiubiquitinated Cyclin A, Homo sapiens" xref: Reactome:REACT_78867 "Degradation multiubiquitinated Cyclin A, Rattus norvegicus" xref: Reactome:REACT_80748 "Degradation multiubiquitinated Cyclin A, Bos taurus" xref: Reactome:REACT_88610 "Degradation multiubiquitinated Cyclin A, Canis familiaris" xref: Reactome:REACT_88818 "Degradation multiubiquitinated Cyclin A, Drosophila melanogaster" xref: Reactome:REACT_96387 "Degradation multiubiquitinated Cyclin A, Mus musculus" xref: Reactome:REACT_97709 "Degradation multiubiquitinated Cyclin A, Danio rerio" is_a: GO:0006511 ! ubiquitin-dependent protein catabolic process is_a: GO:0010498 ! proteasomal protein catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043162 name: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation." [GOC:jl, PMID:11511343] synonym: "ubiquitin-dependent protein breakdown via the multivesicular body pathway" EXACT [] synonym: "ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT [] synonym: "ubiquitin-dependent protein catabolism via the MVB pathway" EXACT [] synonym: "ubiquitin-dependent protein degradation via the multivesicular body pathway" EXACT [] is_a: GO:0006511 ! ubiquitin-dependent protein catabolic process relationship: has_part GO:0007039 ! protein catabolic process in the vacuole relationship: has_part GO:0071985 ! multivesicular body sorting pathway property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043167 name: ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with ions, charged atoms or groups of atoms." [GOC:jl] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "atom binding" RELATED [] is_a: GO:0005488 ! binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043168 name: anion binding namespace: molecular_function def: "Interacting selectively and non-covalently with anions, charged atoms or groups of atoms with a net negative charge." [GOC:jl] subset: gosubset_prok is_a: GO:0043167 ! ion binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043170 name: macromolecule metabolic process namespace: biological_process alt_id: GO:0043283 def: "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [CHEBI:33694, GOC:mah] subset: goslim_pir subset: gosubset_prok synonym: "biopolymer metabolic process" EXACT [GOC:mtg_chebi_dec09] synonym: "macromolecule metabolism" EXACT [] is_a: GO:0071704 ! organic substance metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043177 name: organic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with an organic acid, any acidic compound containing carbon in covalent linkage." [GOC:jl, ISBN:0198506732] subset: gosubset_prok is_a: GO:0036094 ! small molecule binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043178 name: alcohol binding namespace: molecular_function def: "Interacting selectively and non-covalently with an alcohol, any of a class of alkyl compounds containing a hydroxyl group." [GOC:jl, ISBN:0198506732] subset: goslim_pir subset: gosubset_prok is_a: GO:0036094 ! small molecule binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043226 name: organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: gosubset_prok xref: NIF_Subcellular:sao1539965131 xref: Wikipedia:Organelle is_a: GO:0005575 ! cellular_component property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043227 name: membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] subset: gosubset_prok synonym: "membrane-enclosed organelle" EXACT [] xref: NIF_Subcellular:sao414196390 is_a: GO:0043226 ! organelle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043228 name: non-membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] subset: gosubset_prok synonym: "non-membrane-enclosed organelle" EXACT [] xref: NIF_Subcellular:sao1456184038 is_a: GO:0043226 ! organelle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043229 name: intracellular organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators] subset: goslim_pir subset: gosubset_prok is_a: GO:0043226 ! organelle is_a: GO:0044424 ! intracellular part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043231 name: intracellular membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators] subset: goslim_pir subset: gosubset_prok synonym: "intracellular membrane-enclosed organelle" EXACT [] is_a: GO:0043227 ! membrane-bounded organelle is_a: GO:0043229 ! intracellular organelle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043232 name: intracellular non-membrane-bounded organelle namespace: cellular_component def: "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators] subset: goslim_pir subset: gosubset_prok synonym: "intracellular non-membrane-enclosed organelle" EXACT [] is_a: GO:0043228 ! non-membrane-bounded organelle is_a: GO:0043229 ! intracellular organelle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043233 name: organelle lumen namespace: cellular_component def: "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah] is_a: GO:0031974 ! membrane-enclosed lumen is_a: GO:0044422 ! organelle part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043234 name: protein complex namespace: cellular_component def: "A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/] comment: A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole. subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: gosubset_prok synonym: "protein-protein complex" EXACT [] xref: Wikipedia:Protein_complex is_a: GO:0032991 ! macromolecular complex property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043241 name: protein complex disassembly namespace: biological_process def: "The disaggregation of a protein complex into its constituent components. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups." [GOC:jl] subset: gosubset_prok is_a: GO:0032984 ! macromolecular complex disassembly is_a: GO:0071822 ! protein complex subunit organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043279 name: response to alkaloid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active." [CHEBI:22315, GOC:jl] is_a: GO:0010243 ! response to organonitrogen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043328 name: protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway namespace: biological_process def: "The process of directing proteins towards the vacuole using signals contained within the protein, occurring that contributes to protein catabolism via the multivesicular body (MVB) pathway." [GOC:jl, PMID:11511343] synonym: "protein targeting to vacuole during ubiquitin-dependent protein breakdown via the MVB pathway" EXACT [] synonym: "protein targeting to vacuole during ubiquitin-dependent protein catabolic process via the MVB pathway" RELATED [GOC:dph, GOC:tb] synonym: "protein targeting to vacuole during ubiquitin-dependent protein degradation via the MVB pathway" EXACT [] synonym: "protein vacuolar targeting during ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT [] synonym: "protein vacuolar targeting during ubiquitin-dependent protein catabolism via the MVB pathway" EXACT [] synonym: "protein-vacuolar targeting during ubiquitin-dependent protein breakdown via the MVB pathway" EXACT [] synonym: "protein-vacuolar targeting during ubiquitin-dependent protein degradation via the MVB pathway" EXACT [] synonym: "protein-vacuole targeting during ubiquitin-dependent protein catabolic process via the MVB pathway" EXACT [] synonym: "protein-vacuole targeting during ubiquitin-dependent protein catabolism via the MVB pathway" EXACT [] is_a: GO:0006623 ! protein targeting to vacuole is_a: GO:0032511 ! late endosome to vacuole transport via multivesicular body sorting pathway intersection_of: GO:0006623 ! protein targeting to vacuole intersection_of: part_of GO:0043162 ! ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway relationship: part_of GO:0043162 ! ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043332 name: mating projection tip namespace: cellular_component def: "The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth." [GOC:mcc] synonym: "conjugation tube tip" NARROW [] synonym: "shmoo tip" NARROW [] is_a: GO:0030427 ! site of polarized growth is_a: GO:0044463 ! cell projection part intersection_of: GO:0030427 ! site of polarized growth intersection_of: part_of GO:0005937 ! mating projection relationship: part_of GO:0005937 ! mating projection property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043412 name: macromolecule modification namespace: biological_process def: "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators] subset: goslim_pir subset: gosubset_prok is_a: GO:0043170 ! macromolecule metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043413 name: macromolecule glycosylation namespace: biological_process def: "The covalent attachment of a glycosyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule." [GOC:jl] subset: gosubset_prok is_a: GO:0043412 ! macromolecule modification is_a: GO:0070085 ! glycosylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043414 name: macromolecule methylation namespace: biological_process def: "The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule." [GOC:go_curators] subset: gosubset_prok is_a: GO:0032259 ! methylation is_a: GO:0043412 ! macromolecule modification is_a: GO:0044260 ! cellular macromolecule metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043436 name: oxoacid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [CHEBI:24833] subset: gosubset_prok synonym: "keto acid metabolic process" EXACT [] synonym: "keto acid metabolism" EXACT [] synonym: "ketoacid metabolic process" EXACT [] synonym: "ketoacid metabolism" EXACT [] synonym: "oxo acid metabolic process" EXACT [] synonym: "oxo acid metabolism" EXACT [] synonym: "oxoacid metabolism" EXACT [] is_a: GO:0006082 ! organic acid metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043462 name: regulation of ATPase activity namespace: biological_process def: "Any process that modulates the rate of ATP hydrolysis by an ATPase." [GOC:jl] synonym: "regulation of adenosinetriphosphatase activity" EXACT [] is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016887 ! ATPase activity relationship: regulates GO:0016887 ! ATPase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043473 name: pigmentation namespace: biological_process def: "The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells." [GOC:jl] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: gosubset_prok is_a: GO:0044699 ! single-organism process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043486 name: histone exchange namespace: biological_process def: "The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits." [GOC:jl, PMID:11735001, PMID:15066277] comment: Note that this term also includes the exchange of sperm-specific histones or protamines with histones, occurring during spermatogenesis and fertilization. synonym: "histone chaperone" RELATED [GOC:vw] synonym: "histone replacement" EXACT [] is_a: GO:0034728 ! nucleosome organization is_a: GO:0043044 ! ATP-dependent chromatin remodeling relationship: has_part GO:0001207 ! histone displacement property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043492 name: ATPase activity, coupled to movement of substances namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance." [GOC:jl] subset: gosubset_prok is_a: GO:0042623 ! ATPase activity, coupled property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043531 name: ADP binding namespace: molecular_function def: "Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate." [GOC:jl] synonym: "adenosine 5'-diphosphate binding" EXACT [] synonym: "adenosine diphosphate binding" EXACT [] is_a: GO:0032550 ! purine ribonucleoside binding is_a: GO:0032559 ! adenyl ribonucleotide binding is_a: GO:0043168 ! anion binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043543 name: protein acylation namespace: biological_process def: "The addition of an acyl group, any group or radical of the form RCO- where R is an organic group, to a protein amino acid." [GOC:jl] subset: goslim_yeast subset: gosubset_prok synonym: "protein amino acid acylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043555 name: regulation of translation in response to stress namespace: biological_process def: "Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl] synonym: "translational stress response" EXACT [] is_a: GO:0006417 ! regulation of translation is_a: GO:0033554 ! cellular response to stress property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043556 name: regulation of translation in response to oxidative stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl] is_a: GO:0043555 ! regulation of translation in response to stress relationship: part_of GO:0034599 ! cellular response to oxidative stress property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043557 name: regulation of translation in response to osmotic stress namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:jl] is_a: GO:0006970 ! response to osmotic stress is_a: GO:0043555 ! regulation of translation in response to stress property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043562 name: cellular response to nitrogen levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of inorganic nitrogen." [GOC:jl] subset: gosubset_prok is_a: GO:0031669 ! cellular response to nutrient levels property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043565 name: sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl] subset: gosubset_prok synonym: "sequence specific DNA binding" EXACT [] is_a: GO:0003677 ! DNA binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043566 name: structure-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding." [GOC:jl] subset: gosubset_prok synonym: "structure specific DNA binding" EXACT [] is_a: GO:0003677 ! DNA binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043570 name: maintenance of DNA repeat elements namespace: biological_process def: "Any process involved in sustaining the fidelity and copy number of DNA repeat elements." [GOC:jl] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0044710 ! single-organism metabolic process is_a: GO:0051276 ! chromosome organization is_a: GO:1902589 ! single-organism organelle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043574 name: peroxisomal transport namespace: biological_process def: "Transport of substances into, out of or within a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:jl] is_a: GO:1902582 ! single-organism intracellular transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043596 name: nuclear replication fork namespace: cellular_component def: "The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu] is_a: GO:0005657 ! replication fork is_a: GO:0044454 ! nuclear chromosome part intersection_of: GO:0005657 ! replication fork intersection_of: part_of GO:0005634 ! nucleus relationship: has_part GO:0071162 ! CMG complex relationship: part_of GO:0005634 ! nucleus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043603 name: cellular amide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." [CHEBI:32988] subset: goslim_pir subset: gosubset_prok synonym: "amide metabolism" EXACT [] is_a: GO:0034641 ! cellular nitrogen compound metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043604 name: amide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [CHEBI:32988] is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043623 name: cellular protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell." [GOC:jl] subset: gosubset_prok is_a: GO:0006461 ! protein complex assembly is_a: GO:0034622 ! cellular macromolecular complex assembly property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043624 name: cellular protein complex disassembly namespace: biological_process def: "The disaggregation of a protein complex into its constituent components, occurring at the level of an individual cell. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups." [GOC:jl] subset: gosubset_prok is_a: GO:0043241 ! protein complex disassembly property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043628 name: ncRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a non-coding RNA molecule." [GOC:jl] synonym: "ncRNA 3' end processing" EXACT [] is_a: GO:0031123 ! RNA 3'-end processing is_a: GO:0034470 ! ncRNA processing property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043632 name: modification-dependent macromolecule catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl] subset: gosubset_prok is_a: GO:0044265 ! cellular macromolecule catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043689 name: cell-cell adhesion involved in flocculation namespace: biological_process def: "The attachment of one single cell organism to another via adhesion molecules, occurring as a part of flocculation." [GOC:dos, GOC:jl] subset: gosubset_prok is_a: GO:0098741 ! adhesion between unicellular organisms via cell-wall interaction intersection_of: GO:0098741 ! adhesion between unicellular organisms via cell-wall interaction intersection_of: part_of GO:0000128 ! flocculation relationship: part_of GO:0000128 ! flocculation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043690 name: cell-cell adhesion involved in flocculation via cell wall protein-carbohydrate interaction namespace: biological_process def: "The attachment of one single cell organism to another during flocculation via the interaction a protein in the cell wall of one cell with a carbohydrate in the cell wall of another In Saccharomyces this process is mannose-sensitive." [GOC:dos, GOC:jl] subset: gosubset_prok is_a: GO:0043689 ! cell-cell adhesion involved in flocculation intersection_of: GO:0098610 ! adhesion between unicellular organisms intersection_of: part_of GO:0000501 ! flocculation via cell wall protein-carbohydrate interaction relationship: part_of GO:0000501 ! flocculation via cell wall protein-carbohydrate interaction property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043900 name: regulation of multi-organism process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species." [GOC:jl] subset: gosubset_prok is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0051704 ! multi-organism process relationship: regulates GO:0051704 ! multi-organism process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043916 name: DNA-7-methylguanine glycosylase activity namespace: molecular_function def: "Catalysis of the reaction: DNA containing 7-methylguanine + H2O = DNA with abasic site + 7-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methylguanine and the deoxyribose sugar to remove the 7-methylguanine, leaving an abasic site." [GOC:jl, PMID:16468998] subset: gosubset_prok xref: EC:3.2.2.21 xref: IMG:03021 xref: MetaCyc:3.2.2.21-RXN is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043933 name: macromolecular complex subunit organization namespace: biological_process alt_id: GO:0034600 alt_id: GO:0034621 def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a macromolecular complex." [GOC:mtg_mpo] subset: gosubset_prok synonym: "cellular macromolecular complex organization" EXACT [] synonym: "cellular macromolecular complex subunit organisation" EXACT [GOC:curators] synonym: "cellular macromolecular complex subunit organization" EXACT [] synonym: "macromolecular complex organization" EXACT [] synonym: "macromolecular complex subunit organisation" EXACT [GOC:curators] is_a: GO:0016043 ! cellular component organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043934 name: sporulation namespace: biological_process def: "The process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure. A spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo_curators] subset: goslim_metagenomics subset: goslim_yeast xref: Wikipedia:Spore is_a: GO:0044767 ! single-organism developmental process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043935 name: sexual sporulation resulting in formation of a cellular spore namespace: biological_process def: "The formation of spores derived from the products of meiosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo_curators] is_a: GO:0034293 ! sexual sporulation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043954 name: cellular component maintenance namespace: biological_process alt_id: GO:0071956 def: "The organization process that preserves a cellular component in a stable functional or structural state." [GOC:dph, GOC:jl, GOC:mah] synonym: "cellular component maintenance at cellular level" EXACT [] is_a: GO:0016043 ! cellular component organization is_a: GO:0044763 ! single-organism cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043966 name: histone H3 acetylation namespace: biological_process def: "The modification of histone H3 by the addition of an acetyl group." [GOC:jl] is_a: GO:0016573 ! histone acetylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043967 name: histone H4 acetylation namespace: biological_process def: "The modification of histone H4 by the addition of an acetyl group." [GOC:jl] is_a: GO:0016573 ! histone acetylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043970 name: histone H3-K9 acetylation namespace: biological_process def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 9 of the histone." [GOC:jl] synonym: "histone H3 acetylation at K9" EXACT [] synonym: "histone H3K9 acetylation" EXACT [] is_a: GO:0043966 ! histone H3 acetylation is_a: GO:0061647 ! histone H3-K9 modification property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043973 name: histone H3-K4 acetylation namespace: biological_process def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 4 of the histone." [GOC:jl] synonym: "histone H3 acetylation at K4" EXACT [] synonym: "histone H3K4 acetylation" EXACT [] is_a: GO:0043966 ! histone H3 acetylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043984 name: histone H4-K16 acetylation namespace: biological_process def: "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone." [GOC:jl] synonym: "histone H4 acetylation at K16" EXACT [] is_a: GO:0043967 ! histone H4 acetylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0043987 name: histone H3-S10 phosphorylation namespace: biological_process alt_id: GO:0043986 def: "The modification of histone H3 by the addition of an phosphate group to a serine residue at position 10 of the histone." [GOC:jl] synonym: "histone H3 phosphorylation at S10" EXACT [] synonym: "histone H3S10 phosphorylation" EXACT [] is_a: GO:0035404 ! histone-serine phosphorylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044042 name: glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues." [GOC:jl] subset: gosubset_prok synonym: "glucan metabolism" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044085 name: cellular component biogenesis namespace: biological_process alt_id: GO:0071843 def: "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah] subset: gosubset_prok synonym: "cellular component biogenesis at cellular level" EXACT [] is_a: GO:0071840 ! cellular component organization or biogenesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044091 name: membrane biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane." [GOC:jl] is_a: GO:0044085 ! cellular component biogenesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044092 name: negative regulation of molecular function namespace: biological_process def: "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0003674 ! molecular_function relationship: negatively_regulates GO:0003674 ! molecular_function property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jane creation_date: 2009-04-21T04:07:27Z [Term] id: GO:0044093 name: positive regulation of molecular function namespace: biological_process def: "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl] is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0003674 ! molecular_function relationship: positively_regulates GO:0003674 ! molecular_function property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jane creation_date: 2009-04-21T04:11:06Z [Term] id: GO:0044107 name: cellular alcohol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, as carried out by individual cells." [GOC:jl] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0044237 ! cellular metabolic process is_a: GO:0044763 ! single-organism cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jane creation_date: 2009-07-15T01:36:19Z [Term] id: GO:0044108 name: cellular alcohol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, carried out at the level of an individual cell." [GOC:jl] is_a: GO:0044107 ! cellular alcohol metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0046165 ! alcohol biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jane creation_date: 2009-07-15T01:38:25Z [Term] id: GO:0044154 name: histone H3-K14 acetylation namespace: biological_process def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 14 of the histone." [GOC:jl, GOC:lb, PMID:17194708] synonym: "histone H3 acetylation at K14" EXACT [] synonym: "histone H3K14 acetylation" EXACT [] is_a: GO:0043966 ! histone H3 acetylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jane creation_date: 2009-08-11T03:40:43Z [Term] id: GO:0044182 name: filamentous growth of a population of unicellular organisms namespace: biological_process def: "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:mtg_cambridge_2009] is_a: GO:0030447 ! filamentous growth property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jane creation_date: 2009-09-25T10:18:32Z [Term] id: GO:0044212 name: transcription regulatory region DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:jl, GOC:txnOH, SO:0005836] comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". is_a: GO:0000975 ! regulatory region DNA binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jane creation_date: 2009-11-04T12:58:25Z [Term] id: GO:0044237 name: cellular metabolic process namespace: biological_process def: "The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators] subset: goslim_pir subset: gosubset_prok synonym: "cellular metabolism" EXACT [] synonym: "intermediary metabolism" RELATED [GOC:mah] is_a: GO:0008152 ! metabolic process is_a: GO:0009987 ! cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044238 name: primary metabolic process namespace: biological_process def: "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators, http://www.metacyc.org] subset: goslim_pir subset: gosubset_prok synonym: "primary metabolism" EXACT [] is_a: GO:0008152 ! metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044247 name: cellular polysaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of many (typically more than 10) monosaccharide residues linked glycosidically, as carried out by individual cells." [CHEBI:18154, GOC:jl] subset: gosubset_prok synonym: "cellular polysaccharide breakdown" EXACT [] synonym: "cellular polysaccharide catabolism" EXACT [] synonym: "cellular polysaccharide degradation" EXACT [] is_a: GO:0000272 ! polysaccharide catabolic process is_a: GO:0044264 ! cellular polysaccharide metabolic process is_a: GO:0044275 ! cellular carbohydrate catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044248 name: cellular catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:jl] subset: gosubset_prok synonym: "cellular breakdown" EXACT [] synonym: "cellular catabolism" EXACT [] synonym: "cellular degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0044237 ! cellular metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044249 name: cellular biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl] subset: gosubset_prok synonym: "cellular anabolism" EXACT [] synonym: "cellular biosynthesis" EXACT [] synonym: "cellular formation" EXACT [] synonym: "cellular synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0044237 ! cellular metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044255 name: cellular lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl] subset: goslim_pir subset: gosubset_prok synonym: "cellular lipid metabolism" EXACT [] xref: Reactome:REACT_100469 "Fatty acid, triacylglycerol, and ketone body metabolism, Rattus norvegicus" xref: Reactome:REACT_101288 "Peroxisomal lipid metabolism, Bos taurus" xref: Reactome:REACT_101329 "Fatty acid, triacylglycerol, and ketone body metabolism, Mus musculus" xref: Reactome:REACT_102412 "Fatty acid, triacylglycerol, and ketone body metabolism, Canis familiaris" xref: Reactome:REACT_106581 "Peroxisomal lipid metabolism, Rattus norvegicus" xref: Reactome:REACT_106990 "Fatty acid, triacylglycerol, and ketone body metabolism, Xenopus tropicalis" xref: Reactome:REACT_107435 "Peroxisomal lipid metabolism, Danio rerio" xref: Reactome:REACT_108484 "Peroxisomal lipid metabolism, Dictyostelium discoideum" xref: Reactome:REACT_112736 "Peroxisomal lipid metabolism, Plasmodium falciparum" xref: Reactome:REACT_16957 "Peroxisomal lipid metabolism, Homo sapiens" xref: Reactome:REACT_22279 "Fatty acid, triacylglycerol, and ketone body metabolism, Homo sapiens" xref: Reactome:REACT_28392 "Fatty acid, triacylglycerol, and ketone body metabolism, Arabidopsis thaliana" xref: Reactome:REACT_28564 "Peroxisomal lipid metabolism, Canis familiaris" xref: Reactome:REACT_28948 "Peroxisomal lipid metabolism, Mus musculus" xref: Reactome:REACT_29328 "Fatty acid, triacylglycerol, and ketone body metabolism, Mycobacterium tuberculosis" xref: Reactome:REACT_31891 "Fatty acid, triacylglycerol, and ketone body metabolism, Caenorhabditis elegans" xref: Reactome:REACT_32011 "Fatty acid, triacylglycerol, and ketone body metabolism, Danio rerio" xref: Reactome:REACT_32998 "Peroxisomal lipid metabolism, Schizosaccharomyces pombe" xref: Reactome:REACT_34149 "Fatty acid, triacylglycerol, and ketone body metabolism, Taeniopygia guttata" xref: Reactome:REACT_79191 "Peroxisomal lipid metabolism, Drosophila melanogaster" xref: Reactome:REACT_79497 "Peroxisomal lipid metabolism, Taeniopygia guttata" xref: Reactome:REACT_81034 "Peroxisomal lipid metabolism, Gallus gallus" xref: Reactome:REACT_81319 "Peroxisomal lipid metabolism, Arabidopsis thaliana" xref: Reactome:REACT_82818 "Peroxisomal lipid metabolism, Caenorhabditis elegans" xref: Reactome:REACT_83359 "Fatty acid, triacylglycerol, and ketone body metabolism, Sus scrofa" xref: Reactome:REACT_84205 "Fatty acid, triacylglycerol, and ketone body metabolism, Gallus gallus" xref: Reactome:REACT_84404 "Peroxisomal lipid metabolism, Mycobacterium tuberculosis" xref: Reactome:REACT_86890 "Fatty acid, triacylglycerol, and ketone body metabolism, Staphylococcus aureus N315" xref: Reactome:REACT_87163 "Peroxisomal lipid metabolism, Staphylococcus aureus N315" xref: Reactome:REACT_87905 "Fatty acid, triacylglycerol, and ketone body metabolism, Drosophila melanogaster" xref: Reactome:REACT_89268 "Fatty acid, triacylglycerol, and ketone body metabolism, Dictyostelium discoideum" xref: Reactome:REACT_90141 "Fatty acid, triacylglycerol, and ketone body metabolism, Plasmodium falciparum" xref: Reactome:REACT_92117 "Peroxisomal lipid metabolism, Escherichia coli" xref: Reactome:REACT_93461 "Fatty acid, triacylglycerol, and ketone body metabolism, Bos taurus" xref: Reactome:REACT_94360 "Peroxisomal lipid metabolism, Saccharomyces cerevisiae" xref: Reactome:REACT_96855 "Fatty acid, triacylglycerol, and ketone body metabolism, Escherichia coli" xref: Reactome:REACT_97999 "Fatty acid, triacylglycerol, and ketone body metabolism, Schizosaccharomyces pombe" xref: Reactome:REACT_98520 "Peroxisomal lipid metabolism, Oryza sativa" xref: Reactome:REACT_98981 "Fatty acid, triacylglycerol, and ketone body metabolism, Saccharomyces cerevisiae" xref: Reactome:REACT_99720 "Fatty acid, triacylglycerol, and ketone body metabolism, Oryza sativa" xref: Reactome:REACT_99861 "Peroxisomal lipid metabolism, Xenopus tropicalis" xref: Reactome:REACT_99881 "Peroxisomal lipid metabolism, Sus scrofa" is_a: GO:0006629 ! lipid metabolic process is_a: GO:0044237 ! cellular metabolic process is_a: GO:0044763 ! single-organism cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044257 name: cellular protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:jl] subset: gosubset_prok synonym: "cellular protein breakdown" EXACT [] synonym: "cellular protein catabolism" EXACT [] synonym: "cellular protein degradation" EXACT [] xref: Reactome:REACT_104979 "Degradation of newly synthesized ApoB-48, Rattus norvegicus" xref: Reactome:REACT_105668 "Degradation of newly synthesized ApoB-48, Mus musculus" xref: Reactome:REACT_107565 "Degradation of newly synthesized ApoB-48, Xenopus tropicalis" xref: Reactome:REACT_28414 "Degradation of newly synthesized ApoB-48, Canis familiaris" xref: Reactome:REACT_30520 "Degradation of newly synthesized ApoB-48, Gallus gallus" xref: Reactome:REACT_34532 "Degradation of newly synthesized ApoB-48, Taeniopygia guttata" xref: Reactome:REACT_6829 "Degradation of newly synthesized ApoB-48, Homo sapiens" xref: Reactome:REACT_77105 "Degradation of newly synthesized ApoB-48, Danio rerio" xref: Reactome:REACT_79506 "Degradation of newly synthesized ApoB-48, Sus scrofa" xref: Reactome:REACT_86672 "Degradation of newly synthesized ApoB-48, Bos taurus" is_a: GO:0030163 ! protein catabolic process is_a: GO:0044265 ! cellular macromolecule catabolic process is_a: GO:0044267 ! cellular protein metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044260 name: cellular macromolecule metabolic process namespace: biological_process alt_id: GO:0034960 def: "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells." [CHEBI:33694, GOC:mah] subset: gosubset_prok synonym: "cellular biopolymer metabolic process" EXACT [GOC:mtg_chebi_dec09] synonym: "cellular macromolecule metabolism" EXACT [] is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:0044237 ! cellular metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044262 name: cellular carbohydrate metabolic process namespace: biological_process alt_id: GO:0006092 def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl] subset: gosubset_prok synonym: "cellular carbohydrate metabolism" EXACT [] synonym: "main pathways of carbohydrate metabolic process" NARROW [] synonym: "main pathways of carbohydrate metabolism" NARROW [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0044237 ! cellular metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044264 name: cellular polysaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, as carried out by individual cells." [GOC:jl] subset: gosubset_prok synonym: "cellular glycan metabolic process" EXACT [] synonym: "cellular glycan metabolism" EXACT [] synonym: "cellular polysaccharide metabolism" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process is_a: GO:0044260 ! cellular macromolecule metabolic process is_a: GO:0044262 ! cellular carbohydrate metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044265 name: cellular macromolecule catabolic process namespace: biological_process alt_id: GO:0034962 def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, as carried out by individual cells." [CHEBI:33694, GOC:jl] subset: gosubset_prok synonym: "cellular biopolymer catabolic process" EXACT [GOC:mtg_chebi_dec09] synonym: "cellular macromolecule breakdown" EXACT [] synonym: "cellular macromolecule catabolism" EXACT [] synonym: "cellular macromolecule degradation" EXACT [] is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:0044260 ! cellular macromolecule metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044267 name: cellular protein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl] subset: gosubset_prok synonym: "cellular protein metabolism" EXACT [] xref: Reactome:REACT_101554 "Metabolism of proteins, Gallus gallus" xref: Reactome:REACT_102155 "Metabolism of proteins, Arabidopsis thaliana" xref: Reactome:REACT_105825 "Metabolism of proteins, Dictyostelium discoideum" xref: Reactome:REACT_106151 "Metabolism of proteins, Xenopus tropicalis" xref: Reactome:REACT_108005 "Metabolism of proteins, Bos taurus" xref: Reactome:REACT_109022 "Metabolism of proteins, Schizosaccharomyces pombe" xref: Reactome:REACT_17015 "Metabolism of proteins, Homo sapiens" xref: Reactome:REACT_32904 "Metabolism of proteins, Canis familiaris" xref: Reactome:REACT_34473 "Metabolism of proteins, Taeniopygia guttata" xref: Reactome:REACT_80561 "Metabolism of proteins, Escherichia coli" xref: Reactome:REACT_81994 "Metabolism of proteins, Sus scrofa" xref: Reactome:REACT_82523 "Metabolism of proteins, Danio rerio" xref: Reactome:REACT_85873 "Metabolism of proteins, Saccharomyces cerevisiae" xref: Reactome:REACT_86658 "Metabolism of proteins, Drosophila melanogaster" xref: Reactome:REACT_89852 "Metabolism of proteins, Rattus norvegicus" xref: Reactome:REACT_91052 "Metabolism of proteins, Caenorhabditis elegans" xref: Reactome:REACT_93132 "Metabolism of proteins, Mus musculus" xref: Reactome:REACT_96466 "Metabolism of proteins, Plasmodium falciparum" xref: Reactome:REACT_99179 "Metabolism of proteins, Oryza sativa" is_a: GO:0019538 ! protein metabolic process is_a: GO:0044260 ! cellular macromolecule metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044270 name: cellular nitrogen compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732] subset: gosubset_prok synonym: "nitrogen compound breakdown" BROAD [] synonym: "nitrogen compound catabolism" BROAD [] synonym: "nitrogen compound degradation" BROAD [] is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0044248 ! cellular catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044271 name: cellular nitrogen compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732] subset: gosubset_prok synonym: "nitrogen compound anabolism" BROAD [] synonym: "nitrogen compound biosynthesis" BROAD [] synonym: "nitrogen compound formation" BROAD [] synonym: "nitrogen compound synthesis" BROAD [] is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0044249 ! cellular biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044272 name: sulfur compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:jl] subset: gosubset_prok synonym: "sulfur biosynthesis" NARROW [] synonym: "sulfur biosynthetic process" NARROW [] synonym: "sulfur compound anabolism" EXACT [] synonym: "sulfur compound biosynthesis" EXACT [] synonym: "sulfur compound formation" EXACT [] synonym: "sulfur compound synthesis" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0044249 ! cellular biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044275 name: cellular carbohydrate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl] subset: gosubset_prok synonym: "cellular carbohydrate breakdown" EXACT [] synonym: "cellular carbohydrate catabolism" EXACT [] synonym: "cellular carbohydrate degradation" EXACT [] is_a: GO:0016052 ! carbohydrate catabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:0044262 ! cellular carbohydrate metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044281 name: small molecule metabolic process namespace: biological_process def: "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw] comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics synonym: "small molecule metabolism" EXACT [] xref: Reactome:REACT_111217 "Metabolism, Homo sapiens" xref: Reactome:REACT_112077 "Metabolism, Xenopus tropicalis" xref: Reactome:REACT_112140 "Metabolism, Dictyostelium discoideum" xref: Reactome:REACT_112621 "Metabolism, Mus musculus" xref: Reactome:REACT_112912 "Metabolism, Arabidopsis thaliana" xref: Reactome:REACT_113131 "Metabolism, Schizosaccharomyces pombe" xref: Reactome:REACT_113305 "Metabolism, Canis familiaris" xref: Reactome:REACT_113457 "Metabolism, Mycobacterium tuberculosis" xref: Reactome:REACT_113568 "Metabolism, Rattus norvegicus" xref: Reactome:REACT_113610 "Metabolism, Caenorhabditis elegans" xref: Reactome:REACT_113934 "Metabolism, Escherichia coli" xref: Reactome:REACT_114081 "Metabolism, Gallus gallus" xref: Reactome:REACT_114137 "Metabolism, Sus scrofa" xref: Reactome:REACT_114421 "Metabolism, Saccharomyces cerevisiae" xref: Reactome:REACT_114473 "Metabolism, Danio rerio" xref: Reactome:REACT_114495 "Metabolism, Staphylococcus aureus N315" xref: Reactome:REACT_114668 "Metabolism, Plasmodium falciparum" xref: Reactome:REACT_114983 "Metabolism, Drosophila melanogaster" xref: Reactome:REACT_115063 "Metabolism, Taeniopygia guttata" xref: Reactome:REACT_115388 "Metabolism, Oryza sativa" xref: Reactome:REACT_115420 "Metabolism, Bos taurus" xref: Reactome:REACT_115655 "Metabolism, Gallus gallus" is_a: GO:0044710 ! single-organism metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jane creation_date: 2010-01-26T12:05:20Z [Term] id: GO:0044282 name: small molecule catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:vw] comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. synonym: "small molecule catabolism" EXACT [] is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0044712 ! single-organism catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jane creation_date: 2010-01-26T12:06:10Z [Term] id: GO:0044283 name: small molecule biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw] comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. synonym: "small molecule biosynthesis" EXACT [] is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0044711 ! single-organism biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jane creation_date: 2010-01-26T12:06:49Z [Term] id: GO:0044379 name: protein localization to actin cortical patch namespace: biological_process def: "A process in which a protein is transported to, or maintained in, an actin cortical patch." [GOC:mah, PMID:21620704] synonym: "protein localisation to actin cortical patch" EXACT [GOC:mah] is_a: GO:0072697 ! protein localization to cell cortex is_a: GO:1903119 ! protein localization to actin cytoskeleton property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2011-12-08T02:28:42Z [Term] id: GO:0044380 name: protein localization to cytoskeleton namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within the cytoskeleton." [GOC:jl] synonym: "protein localisation to cytoskeleton" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2011-12-13T11:43:24Z [Term] id: GO:0044391 name: ribosomal subunit namespace: cellular_component def: "Either of the two subunits of a ribosome: the ribosomal large subunit or the ribosomal small subunit." [GOC:jl] subset: gosubset_prok is_a: GO:0030529 ! ribonucleoprotein complex is_a: GO:0044444 ! cytoplasmic part is_a: GO:0044446 ! intracellular organelle part relationship: part_of GO:0005840 ! ribosome property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2011-12-15T04:47:59Z [Term] id: GO:0044396 name: actin cortical patch organization namespace: biological_process def: "A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane in cells, at sites of endocytosis." [GOC:jl] synonym: "actin cortical patch organisation" EXACT [GOC:mah] is_a: GO:0016043 ! cellular component organization is_a: GO:0044763 ! single-organism cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2011-12-21T03:33:25Z [Term] id: GO:0044397 name: actin cortical patch internalization namespace: biological_process def: "A process of actin cortical patch localization in which the patch moves from the cell surface to the inside of the cell." [GOC:mah] is_a: GO:0044396 ! actin cortical patch organization is_a: GO:0051666 ! actin cortical patch localization is_a: GO:1902580 ! single-organism cellular localization relationship: has_part GO:0030041 ! actin filament polymerization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2011-12-21T03:37:11Z [Term] id: GO:0044422 name: organelle part namespace: cellular_component def: "Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: goantislim_grouping subset: gocheck_do_not_annotate subset: gosubset_prok is_a: GO:0005575 ! cellular_component intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0043226 ! organelle relationship: part_of GO:0043226 ! organelle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044424 name: intracellular part namespace: cellular_component def: "Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: goantislim_grouping subset: gocheck_do_not_annotate subset: gosubset_prok is_a: GO:0044464 ! cell part intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0005622 ! intracellular relationship: part_of GO:0005622 ! intracellular property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044425 name: membrane part namespace: cellular_component def: "Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: goantislim_grouping subset: gocheck_do_not_annotate subset: gosubset_prok is_a: GO:0005575 ! cellular_component intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0016020 ! membrane relationship: part_of GO:0016020 ! membrane property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044427 name: chromosomal part namespace: cellular_component def: "Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: goantislim_grouping subset: gocheck_do_not_annotate subset: gosubset_prok synonym: "chromosomal component" EXACT [] synonym: "chromosome component" EXACT [] synonym: "chromosome part" EXACT [] is_a: GO:0044446 ! intracellular organelle part intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0005694 ! chromosome relationship: part_of GO:0005694 ! chromosome property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044428 name: nuclear part namespace: cellular_component def: "Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: goantislim_grouping subset: gocheck_do_not_annotate synonym: "nuclear subcomponent" EXACT [NIF_Subcellular:sao1499850686] synonym: "nucleus component" EXACT [] xref: NIF_Subcellular:sao1499850686 is_a: GO:0044446 ! intracellular organelle part intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0005634 ! nucleus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044429 name: mitochondrial part namespace: cellular_component def: "Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: goantislim_grouping subset: gocheck_do_not_annotate synonym: "mitochondrial subcomponent" EXACT [NIF_Subcellular:sao666410040] synonym: "mitochondrion component" EXACT [] xref: NIF_Subcellular:sao666410040 is_a: GO:0044444 ! cytoplasmic part is_a: GO:0044446 ! intracellular organelle part intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005739 ! mitochondrion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044430 name: cytoskeletal part namespace: cellular_component def: "Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: goantislim_grouping subset: gocheck_do_not_annotate synonym: "cytoskeletal element" EXACT [NIF_Subcellular:sao1635329413] synonym: "cytoskeleton component" EXACT [] xref: NIF_Subcellular:sao1635329413 is_a: GO:0044446 ! intracellular organelle part intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0005856 ! cytoskeleton relationship: part_of GO:0005856 ! cytoskeleton property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044431 name: Golgi apparatus part namespace: cellular_component def: "Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: goantislim_grouping subset: gocheck_do_not_annotate synonym: "Golgi component" EXACT [] synonym: "Golgi subcomponent" EXACT [NIF_Subcellular:sao624292949] xref: NIF_Subcellular:sao624292949 is_a: GO:0044444 ! cytoplasmic part is_a: GO:0044446 ! intracellular organelle part intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0005794 ! Golgi apparatus relationship: part_of GO:0005794 ! Golgi apparatus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044432 name: endoplasmic reticulum part namespace: cellular_component def: "Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: goantislim_grouping subset: gocheck_do_not_annotate synonym: "ER component" EXACT [] is_a: GO:0044444 ! cytoplasmic part is_a: GO:0044446 ! intracellular organelle part intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0005783 ! endoplasmic reticulum relationship: part_of GO:0005783 ! endoplasmic reticulum property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044444 name: cytoplasmic part namespace: cellular_component def: "Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: goantislim_grouping subset: gocheck_do_not_annotate subset: gosubset_prok synonym: "cytoplasm component" EXACT [] is_a: GO:0044424 ! intracellular part intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0005737 ! cytoplasm property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044445 name: cytosolic part namespace: cellular_component def: "Any constituent part of cytosol, that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: goantislim_grouping subset: gocheck_do_not_annotate subset: gosubset_prok synonym: "cytosol component" EXACT [] is_a: GO:0044444 ! cytoplasmic part intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0005829 ! cytosol relationship: part_of GO:0005829 ! cytosol property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044446 name: intracellular organelle part namespace: cellular_component def: "A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate subset: gosubset_prok is_a: GO:0044422 ! organelle part is_a: GO:0044424 ! intracellular part relationship: part_of GO:0043229 ! intracellular organelle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044448 name: cell cortex part namespace: cellular_component def: "Any constituent part of the cell cortex, the region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: goantislim_grouping subset: gocheck_do_not_annotate is_a: GO:0044444 ! cytoplasmic part intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0005938 ! cell cortex relationship: part_of GO:0005938 ! cell cortex property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044451 name: nucleoplasm part namespace: cellular_component def: "Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: goantislim_grouping subset: gocheck_do_not_annotate is_a: GO:0044428 ! nuclear part intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0005654 ! nucleoplasm relationship: part_of GO:0005654 ! nucleoplasm property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044453 name: nuclear membrane part namespace: cellular_component def: "Any constituent part of the nuclear membrane, the envelope that surrounds the nucleus of eukaryotic cells." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: goantislim_grouping subset: gocheck_do_not_annotate is_a: GO:0044425 ! membrane part is_a: GO:0044428 ! nuclear part intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0031965 ! nuclear membrane relationship: part_of GO:0031965 ! nuclear membrane property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044454 name: nuclear chromosome part namespace: cellular_component def: "Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: goantislim_grouping subset: gocheck_do_not_annotate is_a: GO:0044427 ! chromosomal part is_a: GO:0044428 ! nuclear part intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0000228 ! nuclear chromosome relationship: part_of GO:0000228 ! nuclear chromosome property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044455 name: mitochondrial membrane part namespace: cellular_component def: "Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: goantislim_grouping subset: gocheck_do_not_annotate is_a: GO:0044425 ! membrane part is_a: GO:0044429 ! mitochondrial part intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0031966 ! mitochondrial membrane relationship: part_of GO:0031966 ! mitochondrial membrane property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044463 name: cell projection part namespace: cellular_component def: "Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: goantislim_grouping subset: gocheck_do_not_annotate subset: gosubset_prok is_a: GO:0044464 ! cell part intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0042995 ! cell projection relationship: part_of GO:0042995 ! cell projection property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044464 name: cell part namespace: cellular_component def: "Any constituent part of a cell, the basic structural and functional unit of all organisms." [GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: goantislim_grouping subset: gocheck_do_not_annotate subset: goslim_pir subset: gosubset_prok synonym: "cellular subcomponent" EXACT [NIF_Subcellular:sao628508602] synonym: "protoplast" RELATED [GOC:mah] xref: NIF_Subcellular:sao628508602 is_a: GO:0005575 ! cellular_component intersection_of: GO:0005575 ! cellular_component intersection_of: part_of GO:0005623 ! cell relationship: part_of GO:0005623 ! cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0044648 name: histone H3-K4 dimethylation namespace: biological_process def: "The modification of histone H3 by addition of two methyl groups to lysine at position 4 of the histone." [GOC:jl, PMID:21875999] is_a: GO:0018027 ! peptidyl-lysine dimethylation is_a: GO:0051568 ! histone H3-K4 methylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2012-07-11T01:27:33Z [Term] id: GO:0044690 name: methionine import namespace: biological_process def: "The directed movement of methionine into a cell or organelle." [GOC:mah] is_a: GO:0015821 ! methionine transport is_a: GO:0043090 ! amino acid import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2012-08-15T14:54:38Z [Term] id: GO:0044699 name: single-organism process namespace: biological_process def: "A biological process that involves only one organism." [GOC:jl] synonym: "single organism process" EXACT [] is_a: GO:0008150 ! biological_process disjoint_from: GO:0044848 ! biological phase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2012-09-19T15:05:24Z [Term] id: GO:0044700 name: single organism signaling namespace: biological_process def: "A signaling process occurring within a single organism." [GOC:jl] is_a: GO:0023052 ! signaling is_a: GO:0044699 ! single-organism process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2012-09-19T15:12:49Z [Term] id: GO:0044702 name: single organism reproductive process namespace: biological_process def: "A biological process that directly contributes to the process of producing new individuals, involving a single organism." [GOC:jl] is_a: GO:0022414 ! reproductive process is_a: GO:0044699 ! single-organism process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2012-09-19T15:56:06Z [Term] id: GO:0044703 name: multi-organism reproductive process namespace: biological_process def: "A biological process that directly contributes to the process of producing new individuals, involving another organism." [GOC:jl] is_a: GO:0022414 ! reproductive process is_a: GO:0051704 ! multi-organism process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2012-09-19T15:56:30Z [Term] id: GO:0044707 name: single-multicellular organism process namespace: biological_process def: "A biological process occurring within a single, multicellular organism." [GOC:jl] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0044699 ! single-organism process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2012-09-19T16:07:47Z [Term] id: GO:0044710 name: single-organism metabolic process namespace: biological_process def: "A metabolic process - chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances - which involves a single organism." [GOC:jl] is_a: GO:0008152 ! metabolic process is_a: GO:0044699 ! single-organism process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2012-10-17T15:46:40Z [Term] id: GO:0044711 name: single-organism biosynthetic process namespace: biological_process def: "A biosynthetic process - chemical reactions and pathways resulting in the formation of substances - involving a single organism." [GOC:jl] is_a: GO:0009058 ! biosynthetic process is_a: GO:0044710 ! single-organism metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2012-10-17T15:52:18Z [Term] id: GO:0044712 name: single-organism catabolic process namespace: biological_process def: "A catabolic process - chemical reactions and pathways resulting in the breakdown of substances - which involves a single organism." [GOC:jl] is_a: GO:0009056 ! catabolic process is_a: GO:0044710 ! single-organism metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2012-10-17T15:52:35Z [Term] id: GO:0044723 name: single-organism carbohydrate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carbohydrates, occurring within a single organism." [GOC:jl] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0044710 ! single-organism metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2012-10-23T15:40:34Z [Term] id: GO:0044724 name: single-organism carbohydrate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carbohydrates, occurring within a single organism." [GOC:jl] is_a: GO:0016052 ! carbohydrate catabolic process is_a: GO:0044712 ! single-organism catabolic process is_a: GO:0044723 ! single-organism carbohydrate metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2012-10-23T16:34:39Z [Term] id: GO:0044732 name: mitotic spindle pole body namespace: cellular_component def: "The microtubule organizing center on a spindle that forms as part of mitosis; functionally homologous to the animal cell centrosome." [GOC:vw] is_a: GO:0005816 ! spindle pole body relationship: part_of GO:0072686 ! mitotic spindle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2012-11-06T15:44:02Z [Term] id: GO:0044744 name: protein targeting to nucleus namespace: biological_process def: "The process of directing proteins towards the nucleus, usually using signals contained within the protein." [GOC:jl] is_a: GO:0006605 ! protein targeting is_a: GO:0034504 ! protein localization to nucleus is_a: GO:0051169 ! nuclear transport is_a: GO:0072594 ! establishment of protein localization to organelle is_a: GO:1902580 ! single-organism cellular localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2012-11-07T15:45:54Z [Term] id: GO:0044755 name: pantothenate import into cell namespace: biological_process def: "The directed movement of pantothenate from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:jl] is_a: GO:0098657 ! import into cell is_a: GO:1901688 ! pantothenate import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2012-12-06T13:02:23Z [Term] id: GO:0044756 name: biotin import into cell namespace: biological_process def: "The directed movement of biotin from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:jl] is_a: GO:0098657 ! import into cell is_a: GO:1901689 ! biotin import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2012-12-06T13:04:45Z [Term] id: GO:0044763 name: single-organism cellular process namespace: biological_process def: "Any process that is carried out at the cellular level, occurring within a single organism." [GOC:jl] is_a: GO:0009987 ! cellular process is_a: GO:0044699 ! single-organism process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2012-12-11T16:56:55Z [Term] id: GO:0044764 name: multi-organism cellular process namespace: biological_process def: "Any process that is carried out at the cellular level which involves another organism of the same or different species." [GOC:jl] is_a: GO:0009987 ! cellular process is_a: GO:0051704 ! multi-organism process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2012-12-11T17:00:50Z [Term] id: GO:0044765 name: single-organism transport namespace: biological_process def: "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore, involving a single organism." [GOC:jl] is_a: GO:0006810 ! transport is_a: GO:1902578 ! single-organism localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2012-12-13T16:25:32Z [Term] id: GO:0044767 name: single-organism developmental process namespace: biological_process def: "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition, involving only one organism." [GOC:jl] is_a: GO:0032502 ! developmental process is_a: GO:0044699 ! single-organism process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2012-12-19T12:21:31Z [Term] id: GO:0044769 name: ATPase activity, coupled to transmembrane movement of ions, rotational mechanism namespace: molecular_function def: "Catalysis of the transfer of ions from one side of a membrane to the other according to the reaction: ATP + H2O + ion(in) = ADP + phosphate + ion(out), by a rotational mechanism." [GOC:jl] is_a: GO:0042625 ! ATPase activity, coupled to transmembrane movement of ions property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2013-02-20T13:41:38Z [Term] id: GO:0044770 name: cell cycle phase transition namespace: biological_process def: "The cell cycle process by which a cell commits to entering the next cell cycle phase." [GOC:mtg_cell_cycle] synonym: "cell cycle transition" EXACT [] is_a: GO:0022402 ! cell cycle process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2013-02-28T12:54:59Z [Term] id: GO:0044772 name: mitotic cell cycle phase transition namespace: biological_process def: "The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle] is_a: GO:0044770 ! cell cycle phase transition is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0044770 ! cell cycle phase transition intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000278 ! mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2013-02-28T13:09:33Z [Term] id: GO:0044773 name: mitotic DNA damage checkpoint namespace: biological_process def: "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] is_a: GO:0000077 ! DNA damage checkpoint is_a: GO:0044774 ! mitotic DNA integrity checkpoint intersection_of: GO:0000077 ! DNA damage checkpoint intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000278 ! mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2013-02-28T15:55:25Z [Term] id: GO:0044774 name: mitotic DNA integrity checkpoint namespace: biological_process alt_id: GO:0070683 def: "A mitotic cell cycle process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction." [GOC:mtg_cell_cycle] synonym: "mitotic cell cycle G2/M transition decatenation checkpoint" EXACT [] synonym: "topo II checkpoint" EXACT [GOC:jp] synonym: "topoisomerase II checkpoint" EXACT [GOC:jp] is_a: GO:0007093 ! mitotic cell cycle checkpoint is_a: GO:0031570 ! DNA integrity checkpoint intersection_of: GO:0031570 ! DNA integrity checkpoint intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000278 ! mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2013-02-28T16:07:26Z [Term] id: GO:0044784 name: metaphase/anaphase transition of cell cycle namespace: biological_process def: "The cell cycle process in which a cell progresses from metaphase to anaphase as part of the cell cycle." [GOC:mtg_cell_cycle] is_a: GO:0010965 ! regulation of mitotic sister chromatid separation is_a: GO:0044770 ! cell cycle phase transition property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2013-05-02T13:09:34Z [Term] id: GO:0044786 name: cell cycle DNA replication namespace: biological_process def: "The DNA-dependent DNA replication that takes place as part of the cell cycle." [GOC:mtg_cell_cycle] is_a: GO:0006261 ! DNA-dependent DNA replication is_a: GO:0022402 ! cell cycle process is_a: GO:0044711 ! single-organism biosynthetic process intersection_of: GO:0006261 ! DNA-dependent DNA replication intersection_of: part_of GO:0007049 ! cell cycle relationship: part_of GO:0007049 ! cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2013-05-02T15:52:22Z [Term] id: GO:0044801 name: single-organism membrane fusion namespace: biological_process def: "The membrane organization process that joins two lipid bilayers to form a single membrane, involving only one organism." [GOC:jl] is_a: GO:0044802 ! single-organism membrane organization is_a: GO:0061025 ! membrane fusion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2013-09-10T15:08:20Z [Term] id: GO:0044802 name: single-organism membrane organization namespace: biological_process def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane, involving only one organism." [GOC:jl] is_a: GO:0044763 ! single-organism cellular process is_a: GO:0061024 ! membrane organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2013-09-10T15:11:17Z [Term] id: GO:0044818 name: mitotic G2/M transition checkpoint namespace: biological_process def: "A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] is_a: GO:0007093 ! mitotic cell cycle checkpoint is_a: GO:0010972 ! negative regulation of G2/M transition of mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2013-11-19T14:20:00Z [Term] id: GO:0044837 name: actomyosin contractile ring organization namespace: biological_process def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of an actomyosin contractile ring." [GOC:mtg_cell_cycle] synonym: "cytokinesis, actomyosin contractile ring organization" EXACT [] is_a: GO:0030866 ! cortical actin cytoskeleton organization is_a: GO:0031032 ! actomyosin structure organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2014-02-26T15:31:31Z [Term] id: GO:0044838 name: cell quiescence namespace: biological_process def: "A specialized resting state that cells enter in response to cues from the cell's environment. Quiescence is characterized by the absence of cell growth and division, by a reprogramming of global gene expression, and by changes characteristic of the organism and specific cell type. Depending on external conditions, quiescence may persist until cell death or cells may resume cell growth and division. In some cell types or under certain conditions, cellular metabolism may proceed." [GOC:jb, GOC:mah] comment: Note that terminally differentiated cells in higher eukaryotes are typically quiescent but metabolically active. Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "cell cycle quiescence" RELATED [GOC:mah] synonym: "cellular quiescence" EXACT [GOC:mah] synonym: "G0 phase" RELATED [GOC:mah] synonym: "quiescence" BROAD [GOC:mah] is_a: GO:0022403 ! cell cycle phase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2014-02-26T16:15:51Z [Term] id: GO:0044839 name: cell cycle G2/M phase transition namespace: biological_process def: "The cell cycle process by which a cell in G2 phase commits to M phase." [GOC:jl, GOC:mtg_cell_cycle] is_a: GO:0044770 ! cell cycle phase transition property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2014-03-05T14:56:45Z [Term] id: GO:0044843 name: cell cycle G1/S phase transition namespace: biological_process def: "The cell cycle process by which a cell in G1 phase commits to S phase." [GOC:mtg_cell_cycle] is_a: GO:0044770 ! cell cycle phase transition property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2014-03-25T16:33:47Z [Term] id: GO:0044844 name: meiotic interphase II namespace: biological_process def: "The cell cycle phase which begins at the end of meiosis I cytokinesis and ends when meiosis II prophase begins. During meiotic interphase II no DNA replication takes place, but the centrioles duplicate and spindle fibres emerge." [GOC:jl, GOC:mtg_cell_cycle] comment: note that this term should not be used for direct annotation. if you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic s-phase). to capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051328 ! meiotic interphase is_a: GO:0098765 ! meiosis II cell cycle phase relationship: happens_during GO:0007135 ! meiosis II property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2014-03-26T16:52:27Z [Term] id: GO:0044848 name: biological phase namespace: biological_process def: "A distinct period or stage in a biological process or cycle." [GOC:jl] comment: Note that phases are is_a disjoint from other biological processes. happens_during relationships can operate between phases and other biological processes e.g. DNA replication happens_during S phase. subset: gocheck_do_not_manually_annotate is_a: GO:0008150 ! biological_process disjoint_from: GO:0050896 ! response to stimulus disjoint_from: GO:0051179 ! localization disjoint_from: GO:0051704 ! multi-organism process disjoint_from: GO:0071840 ! cellular component organization or biogenesis disjoint_from: GO:0098743 ! cell aggregation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2014-07-16T13:12:40Z [Term] id: GO:0044877 name: macromolecular complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with any macromolecular complex." [GOC:jl] is_a: GO:0005488 ! binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2014-12-16T11:38:58Z [Term] id: GO:0044878 name: cytokinesis checkpoint namespace: biological_process def: "A mitotic cell cycle checkpoint that detects a defect in cytokinesis and negatively regulates mitosis in the following cell cycle." [GOC:jl, GOC:mtg_cell_cycle] comment: These cells display defects in cytokinetic ring formation and fail to assemble a septum, but nevertheless enter a new cell cycle, go through one round of DNA replication, and then arrest in G2 of the following cell cycle. synonym: "cytokinesis after mitosis checkpoint" RELATED [GOC:dph, GOC:vw] synonym: "defective cytokinesis checkpoint" RELATED [GOC:dph, GOC:vw] is_a: GO:0007093 ! mitotic cell cycle checkpoint property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: janelomax creation_date: 2015-01-13T15:30:23Z [Term] id: GO:0045005 name: DNA-dependent DNA replication maintenance of fidelity namespace: biological_process def: "A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair." [GOC:mah, GOC:vw] subset: gosubset_prok synonym: "maintenance of fidelity during DNA-dependent DNA replication" RELATED [GOC:dph, GOC:tb] synonym: "maintenance of fidelity involved in DNA-dependent DNA replication" EXACT [] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006261 ! DNA-dependent DNA replication property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045013 name: carbon catabolite repression of transcription namespace: biological_process def: "A transcription regulation process in which the presence of one carbon source leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances." [GOC:mah, ISBN:0198506732, PMID:11018147, PMID:18359269, PMID:9618445] subset: gosubset_prok synonym: "carbon catabolite repression" EXACT [] synonym: "negative regulation of transcription by carbon catabolites" EXACT [GOC:mah] is_a: GO:0045892 ! negative regulation of transcription, DNA-templated is_a: GO:0045990 ! carbon catabolite regulation of transcription property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045014 name: negative regulation of transcription by glucose namespace: biological_process def: "Any process involving glucose that stops, prevents or reduces the rate of transcription. The presence of glucose in the growth medium inhibits the synthesis of certain enzymes in bacteria growing on the medium. For example, transcription of some catabolic operons is under negative control by specific repressors and glucose is an anti-inducer of xylose utilization and glycerol kinase." [ISBN:0198506732, PMID:11018147] subset: gosubset_prok synonym: "down regulation of transcription by glucose" EXACT [] synonym: "down-regulation of transcription by glucose" EXACT [] synonym: "downregulation of transcription by glucose" EXACT [] synonym: "glucose effect" EXACT [] synonym: "glucose repression" EXACT [] synonym: "inhibition of transcription by glucose" NARROW [] is_a: GO:0045013 ! carbon catabolite repression of transcription is_a: GO:0046015 ! regulation of transcription by glucose property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045017 name: glycerolipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone." [GOC:ai] subset: gosubset_prok synonym: "glycerolipid anabolism" EXACT [] synonym: "glycerolipid biosynthesis" EXACT [] synonym: "glycerolipid formation" EXACT [] synonym: "glycerolipid synthesis" EXACT [] is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0046486 ! glycerolipid metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045023 name: G0 to G1 transition namespace: biological_process def: "The mitotic cell cycle phase transition whose occurrence commits the cell from the G0 quiescent state to the G1 phase. Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. Appropriate stimulation of such cells induces them to return to G1 and resume growth and division. The G0 to G1 transition is accompanied by many changes in the program of gene expression." [GOC:mtg_cell_cycle, ISBN:0716731363] is_a: GO:0022402 ! cell cycle process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045026 name: plasma membrane fusion namespace: biological_process alt_id: GO:0006947 def: "The joining of two or more lipid bilayer membranes that surround a cell." [GOC:elh, GOC:mtg_muscle] synonym: "cell fusion" BROAD [] synonym: "cell-cell fusion" BROAD [] is_a: GO:0044801 ! single-organism membrane fusion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045047 name: protein targeting to ER namespace: biological_process def: "The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane." [ISBN:0716731363] synonym: "protein targeting to endoplasmic reticulum" EXACT [] synonym: "protein-endoplasmic reticulum targeting" EXACT [] synonym: "protein-ER targeting" EXACT [] is_a: GO:0006605 ! protein targeting is_a: GO:0016482 ! cytoplasmic transport is_a: GO:0070972 ! protein localization to endoplasmic reticulum is_a: GO:0072599 ! establishment of protein localization to endoplasmic reticulum is_a: GO:1902580 ! single-organism cellular localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045117 name: azole transport namespace: biological_process def: "The directed movement of azoles, heterocyclic compounds found in many biologically important substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:3527307206, Wikipedia:Azole] is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045132 name: meiotic chromosome segregation namespace: biological_process def: "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle." [GOC:ai, GOC:mah] is_a: GO:0098813 ! nuclear chromosome segregation is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0098813 ! nuclear chromosome segregation intersection_of: part_of GO:0007126 ! meiotic nuclear division relationship: part_of GO:0007126 ! meiotic nuclear division property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045141 name: meiotic telomere clustering namespace: biological_process def: "The cell cycle process in which the dynamic reorganization of telomeres occurs in early meiotic prophase, during which meiotic chromosome ends are gathered in a bouquet arrangement at the inner surface of the nuclear envelope proximal to the spindle pole body. This plays an important role in progression through meiosis and precedes synapsis." [GOC:vw, PMID:10690419] synonym: "bouquet biosynthesis" NARROW [] synonym: "bouquet formation" NARROW [] is_a: GO:0034397 ! telomere localization is_a: GO:0070192 ! chromosome organization involved in meiosis is_a: GO:0090220 ! chromosome localization to nuclear envelope involved in homologous chromosome segregation is_a: GO:1902580 ! single-organism cellular localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045143 name: homologous chromosome segregation namespace: biological_process alt_id: GO:0007061 def: "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, ISBN:0815316194] synonym: "meiosis I, chromosome segregation" EXACT [] is_a: GO:0045132 ! meiotic chromosome segregation intersection_of: GO:0098813 ! nuclear chromosome segregation intersection_of: part_of GO:0007127 ! meiosis I relationship: part_of GO:0007127 ! meiosis I property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045144 name: meiotic sister chromatid segregation namespace: biological_process def: "The cell cycle process in which sister chromatids are organized and then physically separated and randomly apportioned to two sets during the second division of the meiotic cell cycle." [GOC:ai, ISBN:0815316194] synonym: "meiosis II, chromosome segregation" EXACT [] is_a: GO:0000819 ! sister chromatid segregation is_a: GO:0045132 ! meiotic chromosome segregation is_a: GO:0070192 ! chromosome organization involved in meiosis intersection_of: GO:0000819 ! sister chromatid segregation intersection_of: part_of GO:0007135 ! meiosis II relationship: part_of GO:0007135 ! meiosis II property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045145 name: single-stranded DNA 5'-3' exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule." [GOC:ai, GOC:elh, PMID:20086101] synonym: "single-stranded DNA specific 5'-3' exodeoxyribonuclease activity" RELATED [] synonym: "ssDNA-specific 5'-3' exodeoxyribonuclease activity" RELATED [GOC:mah] is_a: GO:0008297 ! single-stranded DNA exodeoxyribonuclease activity is_a: GO:0035312 ! 5'-3' exodeoxyribonuclease activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045165 name: cell fate commitment namespace: biological_process def: "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [ISBN:0716731185] comment: Note that this term was 'cell fate determination' but the term name was changed to better match its existing definition and the child term 'cell fate determination; GO:0001709' was also created. is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0030154 ! cell differentiation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045184 name: establishment of protein localization namespace: biological_process def: "The directed movement of a protein to a specific location." [GOC:bf] subset: gosubset_prok synonym: "establishment of protein localisation" EXACT [GOC:mah] synonym: "protein positioning" EXACT [] synonym: "protein recruitment" EXACT [] is_a: GO:0051234 ! establishment of localization relationship: part_of GO:0008104 ! protein localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045185 name: maintenance of protein location namespace: biological_process def: "Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away." [GOC:bf] subset: gosubset_prok synonym: "active protein retrieval" NARROW [] synonym: "maintenance of protein localization" RELATED [GOC:dph, GOC:tb] synonym: "protein retention" NARROW [] synonym: "protein sequestering" NARROW [] is_a: GO:0051235 ! maintenance of location relationship: part_of GO:0008104 ! protein localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045229 name: external encapsulating structure organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir subset: gosubset_prok synonym: "external encapsulating structure organisation" EXACT [GOC:curators] synonym: "external encapsulating structure organization and biogenesis" EXACT [GOC:dph, GOC:jl, GOC:mah] is_a: GO:0016043 ! cellular component organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045277 name: respiratory chain complex IV namespace: cellular_component alt_id: GO:0045287 def: "A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [ISBN:0198547684] subset: goslim_pir subset: gosubset_prok synonym: "cytochrome c oxidase complex" EXACT [] synonym: "electron transport complex IV" RELATED [] is_a: GO:0044424 ! intracellular part is_a: GO:0070069 ! cytochrome complex is_a: GO:0098803 ! respiratory chain complex relationship: part_of GO:0070469 ! respiratory chain property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045324 name: late endosome to vacuole transport namespace: biological_process def: "The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport." [PMID:11872141] is_a: GO:0007034 ! vacuolar transport is_a: GO:0016197 ! endosomal transport is_a: GO:0016482 ! cytoplasmic transport relationship: occurs_in GO:0005622 ! intracellular property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045333 name: cellular respiration namespace: biological_process def: "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)." [GOC:das, ISBN:0140513590, ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "oxidative metabolic process" EXACT [] synonym: "oxidative metabolism" EXACT [] synonym: "respiration" BROAD [] xref: Wikipedia:Cellular_respiration is_a: GO:0015980 ! energy derivation by oxidation of organic compounds property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045472 name: response to ether namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus." [GOC:go_curators] is_a: GO:0010033 ! response to organic substance is_a: GO:1901700 ! response to oxygen-containing compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045547 name: dehydrodolichyl diphosphate synthase activity namespace: molecular_function def: "Catalysis of the condensation of isopentenyl diphosphate and farnesyl diphosphate in the cis-configuration to form dehydrodolichyl diphosphate." [PMID:9858571] is_a: GO:0004659 ! prenyltransferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045595 name: regulation of cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features." [GOC:go_curators] subset: gosubset_prok is_a: GO:0050793 ! regulation of developmental process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0030154 ! cell differentiation relationship: regulates GO:0030154 ! cell differentiation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045732 name: positive regulation of protein catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators] subset: gosubset_prok synonym: "activation of protein catabolic process" NARROW [] synonym: "positive regulation of protein breakdown" EXACT [] synonym: "positive regulation of protein catabolism" EXACT [] synonym: "positive regulation of protein degradation" EXACT [] synonym: "stimulation of protein catabolic process" NARROW [] synonym: "up regulation of protein catabolic process" EXACT [] synonym: "up-regulation of protein catabolic process" EXACT [] synonym: "upregulation of protein catabolic process" EXACT [] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0042176 ! regulation of protein catabolic process is_a: GO:0051247 ! positive regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0030163 ! protein catabolic process relationship: positively_regulates GO:0030163 ! protein catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045786 name: negative regulation of cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of progression through cell cycle" EXACT [] synonym: "down-regulation of progression through cell cycle" EXACT [] synonym: "downregulation of progression through cell cycle" EXACT [] synonym: "inhibition of progression through cell cycle" NARROW [] synonym: "negative regulation of cell cycle progression" EXACT [] synonym: "negative regulation of progression through cell cycle" EXACT [] xref: Reactome:REACT_102454 "p75NTR negatively regulates cell cycle via SC1, Taeniopygia guttata" xref: Reactome:REACT_102880 "p75NTR negatively regulates cell cycle via SC1, Xenopus tropicalis" xref: Reactome:REACT_112803 "p75NTR negatively regulates cell cycle via SC1, Drosophila melanogaster" xref: Reactome:REACT_13695 "p75NTR negatively regulates cell cycle via SC1, Homo sapiens" xref: Reactome:REACT_31060 "p75NTR negatively regulates cell cycle via SC1, Rattus norvegicus" xref: Reactome:REACT_32970 "p75NTR negatively regulates cell cycle via SC1, Sus scrofa" xref: Reactome:REACT_78219 "p75NTR negatively regulates cell cycle via SC1, Gallus gallus" xref: Reactome:REACT_83256 "p75NTR negatively regulates cell cycle via SC1, Bos taurus" xref: Reactome:REACT_88108 "p75NTR negatively regulates cell cycle via SC1, Canis familiaris" xref: Reactome:REACT_93253 "p75NTR negatively regulates cell cycle via SC1, Danio rerio" xref: Reactome:REACT_99982 "p75NTR negatively regulates cell cycle via SC1, Mus musculus" is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007049 ! cell cycle relationship: negatively_regulates GO:0007049 ! cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045787 name: positive regulation of cell cycle namespace: biological_process def: "Any process that activates or increases the rate or extent of progression through the cell cycle." [GOC:go_curators] synonym: "activation of progression through cell cycle" NARROW [] synonym: "positive regulation of cell cycle progression" EXACT [] synonym: "positive regulation of progression through cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of progression through cell cycle" NARROW [] synonym: "up regulation of progression through cell cycle" EXACT [] synonym: "up-regulation of progression through cell cycle" EXACT [] synonym: "upregulation of progression through cell cycle" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007049 ! cell cycle relationship: positively_regulates GO:0007049 ! cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045814 name: negative regulation of gene expression, epigenetic namespace: biological_process def: "Any epigenetic process that stops, prevents or reduces the rate of gene expression." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of gene expression, epigenetic" EXACT [] synonym: "down-regulation of gene expression, epigenetic" EXACT [] synonym: "downregulation of gene expression, epigenetic" EXACT [] synonym: "inhibition of gene expression, epigenetic" NARROW [] is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0040029 ! regulation of gene expression, epigenetic property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045839 name: negative regulation of mitotic nuclear division namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of mitosis" EXACT [] synonym: "down-regulation of mitosis" EXACT [] synonym: "downregulation of mitosis" EXACT [] synonym: "inhibition of mitosis" NARROW [] synonym: "negative regulation of mitosis" EXACT [] is_a: GO:0007088 ! regulation of mitotic nuclear division is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0045930 ! negative regulation of mitotic cell cycle is_a: GO:0051784 ! negative regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007067 ! mitotic nuclear division relationship: negatively_regulates GO:0007067 ! mitotic nuclear division property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045840 name: positive regulation of mitotic nuclear division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitosis." [GOC:go_curators] synonym: "activation of mitosis" NARROW [] synonym: "mitogenic activity" NARROW [] synonym: "positive regulation of mitosis" EXACT [] synonym: "stimulation of mitosis" NARROW [] synonym: "up regulation of mitosis" EXACT [] synonym: "up-regulation of mitosis" EXACT [] synonym: "upregulation of mitosis" EXACT [] is_a: GO:0007088 ! regulation of mitotic nuclear division is_a: GO:0045931 ! positive regulation of mitotic cell cycle is_a: GO:0051785 ! positive regulation of nuclear division is_a: GO:0090068 ! positive regulation of cell cycle process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007067 ! mitotic nuclear division relationship: positively_regulates GO:0007067 ! mitotic nuclear division property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045841 name: negative regulation of mitotic metaphase/anaphase transition namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the mitotic metaphase to anaphase transition." [GOC:go_curators] synonym: "down regulation of mitotic metaphase/anaphase transition" EXACT [] synonym: "down-regulation of mitotic metaphase/anaphase transition" EXACT [] synonym: "downregulation of mitotic metaphase/anaphase transition" EXACT [] synonym: "inhibition of mitotic metaphase/anaphase transition" NARROW [] is_a: GO:0030071 ! regulation of mitotic metaphase/anaphase transition is_a: GO:0032435 ! negative regulation of proteasomal ubiquitin-dependent protein catabolic process is_a: GO:1901991 ! negative regulation of mitotic cell cycle phase transition is_a: GO:1902100 ! negative regulation of metaphase/anaphase transition of cell cycle is_a: GO:2000816 ! negative regulation of mitotic sister chromatid separation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007091 ! metaphase/anaphase transition of mitotic cell cycle relationship: negatively_regulates GO:0007091 ! metaphase/anaphase transition of mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045842 name: positive regulation of mitotic metaphase/anaphase transition namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the mitotic metaphase to anaphase transition." [GOC:go_curators] synonym: "activation of mitotic metaphase/anaphase transition" NARROW [] synonym: "stimulation of mitotic metaphase/anaphase transition" NARROW [] synonym: "up regulation of mitotic metaphase/anaphase transition" EXACT [] synonym: "up-regulation of mitotic metaphase/anaphase transition" EXACT [] synonym: "upregulation of mitotic metaphase/anaphase transition" EXACT [] is_a: GO:0030071 ! regulation of mitotic metaphase/anaphase transition is_a: GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process is_a: GO:1901970 ! positive regulation of mitotic sister chromatid separation is_a: GO:1901992 ! positive regulation of mitotic cell cycle phase transition is_a: GO:1902101 ! positive regulation of metaphase/anaphase transition of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007091 ! metaphase/anaphase transition of mitotic cell cycle relationship: positively_regulates GO:0007091 ! metaphase/anaphase transition of mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045861 name: negative regulation of proteolysis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of proteolysis" EXACT [] synonym: "down-regulation of proteolysis" EXACT [] synonym: "downregulation of proteolysis" EXACT [] synonym: "inhibition of proteolysis" NARROW [] synonym: "negative regulation of peptidolysis" EXACT [] is_a: GO:0030162 ! regulation of proteolysis is_a: GO:0032269 ! negative regulation of cellular protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006508 ! proteolysis relationship: negatively_regulates GO:0006508 ! proteolysis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045862 name: positive regulation of proteolysis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:go_curators] subset: gosubset_prok synonym: "activation of proteolysis" NARROW [] synonym: "positive regulation of peptidolysis" EXACT [] synonym: "stimulation of proteolysis" NARROW [] synonym: "up regulation of proteolysis" EXACT [] synonym: "up-regulation of proteolysis" EXACT [] synonym: "upregulation of proteolysis" EXACT [] is_a: GO:0030162 ! regulation of proteolysis is_a: GO:0032270 ! positive regulation of cellular protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006508 ! proteolysis relationship: positively_regulates GO:0006508 ! proteolysis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045892 name: negative regulation of transcription, DNA-templated namespace: biological_process alt_id: GO:0016481 alt_id: GO:0032582 alt_id: GO:0061021 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] subset: gosubset_prok synonym: "down regulation of gene-specific transcription" RELATED [] synonym: "down regulation of transcription, DNA-dependent" EXACT [] synonym: "down-regulation of gene-specific transcription" RELATED [] synonym: "down-regulation of transcription, DNA-dependent" EXACT [] synonym: "downregulation of gene-specific transcription" RELATED [] synonym: "downregulation of transcription, DNA-dependent" EXACT [] synonym: "inhibition of gene-specific transcription" RELATED [] synonym: "inhibition of transcription, DNA-dependent" NARROW [] synonym: "negative regulation of cellular transcription, DNA-dependent" EXACT [] synonym: "negative regulation of gene-specific transcription" RELATED [] synonym: "negative regulation of transcription, DNA-dependent" EXACT [GOC:txnOH] synonym: "transcription repressor activity" RELATED [] is_a: GO:0006355 ! regulation of transcription, DNA-templated is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:1903507 ! negative regulation of nucleic acid-templated transcription is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006351 ! transcription, DNA-templated relationship: negatively_regulates GO:0006351 ! transcription, DNA-templated property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045893 name: positive regulation of transcription, DNA-templated namespace: biological_process alt_id: GO:0043193 alt_id: GO:0045941 alt_id: GO:0061020 def: "Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] subset: gosubset_prok synonym: "activation of gene-specific transcription" RELATED [] synonym: "activation of transcription, DNA-dependent" NARROW [] synonym: "positive regulation of cellular transcription, DNA-dependent" EXACT [] synonym: "positive regulation of gene-specific transcription" RELATED [] synonym: "positive regulation of transcription, DNA-dependent" EXACT [GOC:txnOH] synonym: "stimulation of gene-specific transcription" NARROW [] synonym: "stimulation of transcription, DNA-dependent" NARROW [] synonym: "transcription activator activity" RELATED [] synonym: "up regulation of gene-specific transcription" RELATED [] synonym: "up regulation of transcription, DNA-dependent" EXACT [] synonym: "up-regulation of gene-specific transcription" RELATED [] synonym: "up-regulation of transcription, DNA-dependent" EXACT [] synonym: "upregulation of gene-specific transcription" RELATED [] synonym: "upregulation of transcription, DNA-dependent" EXACT [] is_a: GO:0006355 ! regulation of transcription, DNA-templated is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:1903508 ! positive regulation of nucleic acid-templated transcription intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006351 ! transcription, DNA-templated relationship: positively_regulates GO:0006351 ! transcription, DNA-templated property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045927 name: positive regulation of growth namespace: biological_process def: "Any process that activates or increases the rate or extent of growth, the increase in size or mass of all or part of an organism." [GOC:go_curators] subset: gosubset_prok synonym: "activation of growth" NARROW [] synonym: "stimulation of growth" NARROW [] synonym: "up regulation of growth" EXACT [] synonym: "up-regulation of growth" EXACT [] synonym: "upregulation of growth" EXACT [] is_a: GO:0040008 ! regulation of growth is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0040007 ! growth relationship: positively_regulates GO:0040007 ! growth property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045930 name: negative regulation of mitotic cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of progression through mitotic cell cycle" EXACT [] synonym: "down-regulation of progression through mitotic cell cycle" EXACT [] synonym: "downregulation of progression through mitotic cell cycle" EXACT [] synonym: "inhibition of progression through mitotic cell cycle" NARROW [] synonym: "negative regulation of mitotic cell cycle progression" EXACT [] synonym: "negative regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0045786 ! negative regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0000278 ! mitotic cell cycle relationship: negatively_regulates GO:0000278 ! mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045931 name: positive regulation of mitotic cell cycle namespace: biological_process def: "Any process that activates or increases the rate or extent of progression through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of progression through mitotic cell cycle" NARROW [] synonym: "positive regulation of mitotic cell cycle progression" EXACT [] synonym: "positive regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of progression through mitotic cell cycle" NARROW [] synonym: "up regulation of progression through mitotic cell cycle" EXACT [] synonym: "up-regulation of progression through mitotic cell cycle" EXACT [] synonym: "upregulation of progression through mitotic cell cycle" EXACT [] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0045787 ! positive regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0000278 ! mitotic cell cycle relationship: positively_regulates GO:0000278 ! mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045934 name: negative regulation of nucleobase-containing compound metabolic process namespace: biological_process def: "Any cellular process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW [] synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006139 ! nucleobase-containing compound metabolic process relationship: negatively_regulates GO:0006139 ! nucleobase-containing compound metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045935 name: positive regulation of nucleobase-containing compound metabolic process namespace: biological_process def: "Any cellular process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] subset: gosubset_prok synonym: "activation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW [] synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] synonym: "stimulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" NARROW [] synonym: "up regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "upregulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0051173 ! positive regulation of nitrogen compound metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006139 ! nucleobase-containing compound metabolic process relationship: positively_regulates GO:0006139 ! nucleobase-containing compound metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045944 name: positive regulation of transcription from RNA polymerase II promoter namespace: biological_process alt_id: GO:0010552 alt_id: GO:0045817 def: "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] synonym: "activation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "activation of transcription from RNA polymerase II promoter" EXACT [] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [] synonym: "positive regulation of global transcription from Pol II promoter" RELATED [] synonym: "positive regulation of transcription from Pol II promoter" EXACT [] synonym: "positive regulation of transcription from RNA polymerase II promoter, global" RELATED [] synonym: "stimulation of global transcription from RNA polymerase II promoter" NARROW [] synonym: "stimulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "up regulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "up regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "up-regulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "up-regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "upregulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "upregulation of transcription from RNA polymerase II promoter" EXACT [] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0045893 ! positive regulation of transcription, DNA-templated intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter relationship: positively_regulates GO:0006366 ! transcription from RNA polymerase II promoter property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0045990 name: carbon catabolite regulation of transcription namespace: biological_process def: "A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources." [GOC:go_curators, GOC:mah, PMID:18359269, PMID:9618445] subset: gosubset_prok synonym: "regulation of transcription by carbon catabolites" EXACT [GOC:mah] is_a: GO:0006355 ! regulation of transcription, DNA-templated relationship: part_of GO:0031670 ! cellular response to nutrient property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046015 name: regulation of transcription by glucose namespace: biological_process def: "Any process involving glucose that modulates the frequency, rate or extent or transcription." [GOC:go_curators] subset: gosubset_prok is_a: GO:0045990 ! carbon catabolite regulation of transcription property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046019 name: regulation of transcription from RNA polymerase II promoter by pheromones namespace: biological_process def: "Any process involving pheromones that modulates the frequency, rate or extent or transcription from an RNA polymerase II promoter." [GOC:go_curators, GOC:txnOH] synonym: "regulation of transcription from Pol II promoter by pheromones" EXACT [] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0009373 ! regulation of transcription by pheromones property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046027 name: phospholipid:diacylglycerol acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phospholipid + 1,2-diacylglycerol = lysophospholipid + triacylglycerol." [EC:2.3.1.158] synonym: "PDAT activity" EXACT [EC:2.3.1.158] synonym: "phospholipid:1,2-diacyl-sn-glycerol O-acyltransferase activity" EXACT [EC:2.3.1.158] xref: EC:2.3.1.158 xref: MetaCyc:2.3.1.158-RXN is_a: GO:0008080 ! N-acetyltransferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046034 name: ATP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators] subset: goslim_metagenomics subset: gosubset_prok synonym: "ATP metabolism" EXACT [] is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process is_a: GO:0046128 ! purine ribonucleoside metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046058 name: cAMP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:go_curators] subset: gosubset_prok synonym: "3',5' cAMP metabolic process" EXACT [] synonym: "3',5' cAMP metabolism" EXACT [] synonym: "3',5'-cAMP metabolic process" EXACT [] synonym: "3',5'-cAMP metabolism" EXACT [] synonym: "adenosine 3',5'-cyclophosphate metabolic process" EXACT [] synonym: "adenosine 3',5'-cyclophosphate metabolism" EXACT [] synonym: "cAMP generating peptide activity" RELATED [] synonym: "cAMP metabolism" EXACT [] synonym: "cyclic AMP metabolic process" EXACT [] synonym: "cyclic AMP metabolism" EXACT [] is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009187 ! cyclic nucleotide metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046075 name: dTTP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dTTP, deoxyribosylthymine triphosphate." [GOC:go_curators] subset: gosubset_prok synonym: "dTTP metabolism" EXACT [] is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046128 name: purine ribonucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai] subset: gosubset_prok synonym: "purine ribonucleoside metabolism" EXACT [] is_a: GO:0009119 ! ribonucleoside metabolic process is_a: GO:0042278 ! purine nucleoside metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046129 name: purine ribonucleoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any purine ribonucleoside, a nucleoside in which purine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:ai] subset: gosubset_prok synonym: "purine ribonucleoside anabolism" EXACT [] synonym: "purine ribonucleoside biosynthesis" EXACT [] synonym: "purine ribonucleoside formation" EXACT [] synonym: "purine ribonucleoside synthesis" EXACT [] is_a: GO:0042451 ! purine nucleoside biosynthetic process is_a: GO:0042455 ! ribonucleoside biosynthetic process is_a: GO:0046128 ! purine ribonucleoside metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046165 name: alcohol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, GOC:ai] subset: gosubset_prok synonym: "alcohol anabolism" EXACT [] synonym: "alcohol biosynthesis" EXACT [] synonym: "alcohol formation" EXACT [] synonym: "alcohol synthesis" EXACT [] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0044283 ! small molecule biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046184 name: aldehyde biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aldehydes, any organic compound with the formula R-CH=O." [GOC:ai] subset: gosubset_prok synonym: "aldehyde anabolism" EXACT [] synonym: "aldehyde biosynthesis" EXACT [] synonym: "aldehyde formation" EXACT [] synonym: "aldehyde synthesis" EXACT [] is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0044711 ! single-organism biosynthetic process is_a: GO:1901576 ! organic substance biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046185 name: aldehyde catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O." [GOC:ai] subset: gosubset_prok synonym: "aldehyde breakdown" EXACT [] synonym: "aldehyde catabolism" EXACT [] synonym: "aldehyde degradation" EXACT [] is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:0044712 ! single-organism catabolic process is_a: GO:1901575 ! organic substance catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046323 name: glucose import namespace: biological_process def: "The directed movement of the hexose monosaccharide glucose into a cell or organelle." [GOC:ai] subset: gosubset_prok synonym: "glucose uptake" EXACT [GOC:dph, GOC:tb] xref: Wikipedia:Glucose_uptake is_a: GO:0015758 ! glucose transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046379 name: extracellular polysaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving polysaccharides used in extracellular structures." [GOC:ai] subset: gosubset_prok synonym: "extracellular polysaccharide metabolism" EXACT [] is_a: GO:0044264 ! cellular polysaccharide metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046385 name: deoxyribose phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [ISBN:0198506732] subset: gosubset_prok synonym: "deoxyribose phosphate anabolism" EXACT [] synonym: "deoxyribose phosphate biosynthesis" EXACT [] synonym: "deoxyribose phosphate formation" EXACT [] synonym: "deoxyribose phosphate synthesis" EXACT [] is_a: GO:0019692 ! deoxyribose phosphate metabolic process is_a: GO:0090407 ! organophosphate biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046390 name: ribose phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ribose phosphate, any phosphorylated ribose sugar." [GOC:ai] subset: gosubset_prok synonym: "ribose phosphate anabolism" EXACT [] synonym: "ribose phosphate biosynthesis" EXACT [] synonym: "ribose phosphate formation" EXACT [] synonym: "ribose phosphate synthesis" EXACT [] is_a: GO:0019693 ! ribose phosphate metabolic process is_a: GO:0090407 ! organophosphate biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046394 name: carboxylic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732] subset: gosubset_prok synonym: "carboxylic acid anabolism" EXACT [] synonym: "carboxylic acid biosynthesis" EXACT [] synonym: "carboxylic acid formation" EXACT [] synonym: "carboxylic acid synthesis" EXACT [] is_a: GO:0016053 ! organic acid biosynthetic process is_a: GO:0019752 ! carboxylic acid metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046395 name: carboxylic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups." [ISBN:0198506732] subset: gosubset_prok synonym: "carboxylic acid breakdown" EXACT [] synonym: "carboxylic acid catabolism" EXACT [] synonym: "carboxylic acid degradation" EXACT [] is_a: GO:0016054 ! organic acid catabolic process is_a: GO:0019752 ! carboxylic acid metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046403 name: polynucleotide 3'-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphopolynucleotide + H2O = a polynucleotide + phosphate. Hydrolyzes the free 3'-phosphate resulting from single strand breaks in DNA due to oxidative damage." [EC:3.1.3.32] synonym: "2'(3')-polynucleotidase activity" EXACT [EC:3.1.3.32] synonym: "5'-polynucleotidekinase 3'-phosphatase activity" EXACT [EC:3.1.3.32] synonym: "deoxyribonucleate 3'-phosphatase activity" EXACT [EC:3.1.3.32] synonym: "DNA 3'-phosphatase activity" EXACT [EC:3.1.3.32] synonym: "polynucleotide 3'-phosphohydrolase activity" EXACT [EC:3.1.3.32] xref: EC:3.1.3.32 xref: MetaCyc:POLYNUCLEOTIDE-3-PHOSPHATASE-RXN is_a: GO:0098518 ! polynucleotide phosphatase activity relationship: part_of GO:0098506 ! polynucleotide 3' dephosphorylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046460 name: neutral lipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of neutral lipids, lipids only soluble in solvents of very low polarity." [GOC:ai] subset: gosubset_prok synonym: "neutral lipid anabolism" EXACT [] synonym: "neutral lipid biosynthesis" EXACT [] synonym: "neutral lipid formation" EXACT [] synonym: "neutral lipid synthesis" EXACT [] is_a: GO:0006638 ! neutral lipid metabolic process is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046463 name: acylglycerol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids." [GOC:ai] subset: gosubset_prok synonym: "acylglycerol anabolism" EXACT [] synonym: "acylglycerol biosynthesis" EXACT [] synonym: "acylglycerol formation" EXACT [] synonym: "acylglycerol synthesis" EXACT [] is_a: GO:0006639 ! acylglycerol metabolic process is_a: GO:0045017 ! glycerolipid biosynthetic process is_a: GO:0046460 ! neutral lipid biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046483 name: heterocycle metabolic process namespace: biological_process def: "The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [CHEBI:5686, ISBN:0198506732] subset: goslim_pir subset: gosubset_prok synonym: "heterocycle metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046486 name: glycerolipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis." [GOC:ai, PMID:8906569] subset: gosubset_prok synonym: "glycerolipid metabolism" EXACT [] is_a: GO:0044255 ! cellular lipid metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046527 name: glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732] subset: gosubset_prok xref: EC:2.4.1.- is_a: GO:0016758 ! transferase activity, transferring hexosyl groups property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046683 name: response to organophosphorus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organophosphorus stimulus. Organophosphorus is a compound containing phosphorus bound to an organic molecule; several organophosphorus compounds are used as insecticides, and they are highly toxic cholinesterase inhibitors." [ISBN:0721662544] synonym: "organophosphorus resistance" RELATED [] synonym: "organophosphorus susceptibility/resistance" RELATED [] is_a: GO:0010033 ! response to organic substance property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046685 name: response to arsenic-containing substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides." [GOC:hjd, ISBN:0721662544] subset: gosubset_prok synonym: "arsenate sensitivity/resistance" RELATED [] synonym: "response to arsenic" EXACT [GOC:curators] is_a: GO:0042221 ! response to chemical property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046686 name: response to cadmium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus." [GOC:ai] subset: gosubset_prok synonym: "cadmium sensitivity/resistance" RELATED [] synonym: "response to cadmium" EXACT [] is_a: GO:0010038 ! response to metal ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046688 name: response to copper ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus." [GOC:ai] subset: gosubset_prok synonym: "copper sensitivity/resistance" RELATED [] synonym: "response to copper" EXACT [] is_a: GO:0010038 ! response to metal ion is_a: GO:1990267 ! response to transition metal nanoparticle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046689 name: response to mercury ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus." [GOC:ai] subset: gosubset_prok synonym: "mercuric sensitivity/resistance" RELATED [] synonym: "response to mercuric ion" NARROW [GOC:mah] synonym: "response to mercury" EXACT [] is_a: GO:0010038 ! response to metal ion is_a: GO:1990267 ! response to transition metal nanoparticle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046700 name: heterocycle catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [GOC:ai] subset: gosubset_prok synonym: "heterocycle breakdown" EXACT [] synonym: "heterocycle catabolism" EXACT [] synonym: "heterocycle degradation" EXACT [] is_a: GO:0044248 ! cellular catabolic process is_a: GO:0046483 ! heterocycle metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046777 name: protein autophosphorylation namespace: biological_process def: "The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation)." [ISBN:0198506732] subset: gosubset_prok synonym: "protein amino acid autophosphorylation" EXACT [GOC:bf] xref: Reactome:REACT_100311 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Canis familiaris" xref: Reactome:REACT_100519 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Bos taurus" xref: Reactome:REACT_106599 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Xenopus tropicalis" xref: Reactome:REACT_108394 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Danio rerio" xref: Reactome:REACT_1116 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Homo sapiens" xref: Reactome:REACT_30997 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Rattus norvegicus" xref: Reactome:REACT_80689 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Oryza sativa" xref: Reactome:REACT_80700 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Sus scrofa" xref: Reactome:REACT_83436 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Arabidopsis thaliana" xref: Reactome:REACT_83727 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Gallus gallus" xref: Reactome:REACT_85871 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Mus musculus" xref: Reactome:REACT_88668 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Drosophila melanogaster" xref: Reactome:REACT_98066 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Saccharomyces cerevisiae" xref: Reactome:REACT_99025 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Taeniopygia guttata" xref: Reactome:REACT_99966 "Intermolecular autophosphorylation of ATM within dimeric ATM complexes, Schizosaccharomyces pombe" xref: Wikipedia:Autophosphorylation is_a: GO:0006468 ! protein phosphorylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046785 name: microtubule polymerization namespace: biological_process def: "The addition of tubulin heterodimers to one or both ends of a microtubule." [GOC:ai, GOC:go_curators] synonym: "microtubule assembly" EXACT [] synonym: "microtubule formation" RELATED [] is_a: GO:0031109 ! microtubule polymerization or depolymerization is_a: GO:0051258 ! protein polymerization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046873 name: metal ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of metal ions from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "heavy metal ion porter activity" NARROW [] synonym: "heavy metal ion transporter activity" NARROW [] synonym: "heavy metal ion:hydrogen symporter activity" NARROW [] synonym: "heavy metal-exporting ATPase activity" NARROW [] synonym: "high affinity metal ion uptake transporter activity" NARROW [] synonym: "low affinity metal ion uptake transporter activity" NARROW [] is_a: GO:0022890 ! inorganic cation transmembrane transporter activity relationship: part_of GO:0030001 ! metal ion transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046903 name: secretion namespace: biological_process def: "The controlled release of a substance by a cell or a tissue." [GOC:ai] subset: goslim_pir subset: gosubset_prok is_a: GO:0044765 ! single-organism transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046906 name: tetrapyrrole binding namespace: molecular_function def: "Interacting selectively and non-covalently with a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position." [CHEBI:26932, GOC:curators, ISBN:0198506732] subset: goslim_pir subset: gosubset_prok synonym: "porphyrin binding" NARROW [] is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046907 name: intracellular transport namespace: biological_process def: "The directed movement of substances within a cell." [GOC:ai] subset: gosubset_prok is_a: GO:0006810 ! transport is_a: GO:0051649 ! establishment of localization in cell relationship: occurs_in GO:0005622 ! intracellular property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046912 name: transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer namespace: molecular_function def: "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer." [GOC:jl] subset: gosubset_prok xref: EC:2.3.3 is_a: GO:0016746 ! transferase activity, transferring acyl groups property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046930 name: pore complex namespace: cellular_component def: "Any small opening in a membrane that allows the passage of gases and/or liquids." [ISBN:0198506732] subset: gosubset_prok synonym: "channel-forming toxin activity" RELATED [] synonym: "pore" EXACT [] synonym: "pore-forming toxin activity" RELATED [] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0016021 ! integral component of membrane property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046933 name: proton-transporting ATP synthase activity, rotational mechanism namespace: molecular_function def: "Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ADP + H2O + phosphate + H+(in) = ATP + H+(out), by a rotational mechanism." [EC:3.6.3.14, TC:3.A.2.1.1] subset: gosubset_prok synonym: "H+-transporting ATP synthase activity" EXACT [EC:3.6.3.14] synonym: "hydrogen ion translocating F-type ATPase activity" EXACT [] synonym: "hydrogen ion transporting ATP synthase activity, rotational mechanism" EXACT [] synonym: "hydrogen ion transporting two-sector ATPase activity" EXACT [] xref: MetaCyc:ATPSYN-RXN xref: Reactome:REACT_104315 "ATP is synthesized from ADP and Pi by ATPase, Bos taurus" xref: Reactome:REACT_105384 "ATP is synthesized from ADP and Pi by ATPase, Rattus norvegicus" xref: Reactome:REACT_106830 "ATP is synthesized from ADP and Pi by ATPase, Canis familiaris" xref: Reactome:REACT_190 "ATP is synthesized from ADP and Pi by ATPase, Homo sapiens" xref: Reactome:REACT_33014 "ATP is synthesized from ADP and Pi by ATPase, Danio rerio" xref: Reactome:REACT_86305 "ATP is synthesized from ADP and Pi by ATPase, Gallus gallus" xref: Reactome:REACT_92655 "ATP is synthesized from ADP and Pi by ATPase, Mus musculus" xref: Reactome:REACT_96844 "ATP is synthesized from ADP and Pi by ATPase, Sus scrofa" is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity is_a: GO:0019829 ! cation-transporting ATPase activity is_a: GO:0044769 ! ATPase activity, coupled to transmembrane movement of ions, rotational mechanism property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046939 name: nucleotide phosphorylation namespace: biological_process def: "The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside." [GOC:ai] subset: gosubset_prok is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0016310 ! phosphorylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046941 name: azetidine-2-carboxylic acid acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-azetidine-2-carboxylic acid + acetyl-CoA = CoA-SH + N-acetyl azetidine-2-carboxylic acid." [PMID:12761200] xref: EC:2.3.1.- is_a: GO:0008080 ! N-acetyltransferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046942 name: carboxylic acid transport namespace: biological_process def: "The directed movement of carboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:ai] subset: gosubset_prok is_a: GO:0015711 ! organic anion transport is_a: GO:0015849 ! organic acid transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0046999 name: regulation of conjugation namespace: biological_process def: "Any process that modulates the rate or frequency of conjugation, the union or introduction of genetic information from compatible mating types that results in a genetically different individual." [GOC:ai] subset: gosubset_prok is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0000746 ! conjugation relationship: regulates GO:0000746 ! conjugation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0048029 name: monosaccharide binding namespace: molecular_function def: "Interacting selectively and non-covalently with any monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [CHEBI:35381, GOC:jid] subset: gosubset_prok is_a: GO:0030246 ! carbohydrate binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0048037 name: cofactor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [ISBN:0198506732] subset: goslim_metagenomics subset: goslim_pir subset: gosubset_prok is_a: GO:0005488 ! binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0048038 name: quinone binding namespace: molecular_function def: "Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds." [ISBN:0198506732] subset: gosubset_prok is_a: GO:0048037 ! cofactor binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0048039 name: ubiquinone binding namespace: molecular_function def: "Interacting selectively and non-covalently with ubiquinone, a quinone derivative with a tail of isoprene units." [GOC:jid, ISBN:0582227089] subset: gosubset_prok synonym: "coenzyme Q binding" EXACT [] synonym: "coenzyme Q6 binding" NARROW [] is_a: GO:0048038 ! quinone binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0048284 name: organelle fusion namespace: biological_process def: "The creation of a single organelle from two or more organelles." [GOC:jid] subset: goslim_pir subset: goslim_yeast is_a: GO:0006996 ! organelle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0048285 name: organelle fission namespace: biological_process def: "The creation of two or more organelles by division of one organelle." [GOC:jid] subset: goslim_pir subset: goslim_yeast is_a: GO:0006996 ! organelle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0048308 name: organelle inheritance namespace: biological_process def: "The partitioning of organelles between daughter cells at cell division." [GOC:jid] subset: goslim_pir subset: goslim_yeast is_a: GO:0006996 ! organelle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0048311 name: mitochondrion distribution namespace: biological_process def: "Any process that establishes the spatial arrangement of mitochondria between and within cells." [GOC:jid] synonym: "distribution of mitochondria" EXACT [] synonym: "mitochondrial distribution" EXACT [] synonym: "positioning of mitochondria" RELATED [] is_a: GO:0007005 ! mitochondrion organization is_a: GO:0051646 ! mitochondrion localization is_a: GO:1902580 ! single-organism cellular localization is_a: GO:1902589 ! single-organism organelle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0048312 name: intracellular distribution of mitochondria namespace: biological_process def: "Any process that establishes the spatial arrangement of mitochondria within the cell." [GOC:jid] synonym: "mitochondria positioning within cell" EXACT [] synonym: "mitochondrion positioning within cell" EXACT [] is_a: GO:0048311 ! mitochondrion distribution intersection_of: GO:0048311 ! mitochondrion distribution intersection_of: occurs_in GO:0005622 ! intracellular relationship: occurs_in GO:0005622 ! intracellular property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0048468 name: cell development namespace: biological_process def: "The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:go_curators] subset: goslim_candida subset: gosubset_prok synonym: "terminal differentiation" RELATED [GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0030154 ! cell differentiation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0048500 name: signal recognition particle namespace: cellular_component def: "A complex of protein and RNA which facilitates translocation of proteins across membranes." [GOC:mlg] subset: goslim_pir subset: gosubset_prok xref: Wikipedia:Signal_recognition_particle is_a: GO:0030529 ! ribonucleoprotein complex is_a: GO:0044444 ! cytoplasmic part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0048513 name: organ development namespace: biological_process def: "Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dph, GOC:jid] synonym: "development of an organ" EXACT [] synonym: "organogenesis" EXACT [] xref: Wikipedia:Organogenesis is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048731 ! system development property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0048518 name: positive regulation of biological process namespace: biological_process alt_id: GO:0043119 def: "Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] subset: gosubset_prok synonym: "activation of biological process" NARROW [] synonym: "positive regulation of physiological process" EXACT [] synonym: "stimulation of biological process" NARROW [] synonym: "up regulation of biological process" EXACT [] synonym: "up-regulation of biological process" EXACT [] synonym: "upregulation of biological process" EXACT [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0008150 ! biological_process relationship: positively_regulates GO:0008150 ! biological_process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0048519 name: negative regulation of biological process namespace: biological_process alt_id: GO:0043118 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:jid] subset: gosubset_prok synonym: "down regulation of biological process" EXACT [] synonym: "down-regulation of biological process" EXACT [] synonym: "downregulation of biological process" EXACT [] synonym: "inhibition of biological process" NARROW [] synonym: "negative regulation of physiological process" EXACT [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0008150 ! biological_process relationship: negatively_regulates GO:0008150 ! biological_process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0048522 name: positive regulation of cellular process namespace: biological_process alt_id: GO:0051242 def: "Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] subset: gosubset_prok synonym: "activation of cellular process" NARROW [] synonym: "positive regulation of cellular physiological process" EXACT [] synonym: "stimulation of cellular process" NARROW [] synonym: "up regulation of cellular process" EXACT [] synonym: "up-regulation of cellular process" EXACT [] synonym: "upregulation of cellular process" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009987 ! cellular process relationship: positively_regulates GO:0009987 ! cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0048523 name: negative regulation of cellular process namespace: biological_process alt_id: GO:0051243 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:jid] subset: gosubset_prok synonym: "down regulation of cellular process" EXACT [] synonym: "down-regulation of cellular process" EXACT [] synonym: "downregulation of cellular process" EXACT [] synonym: "inhibition of cellular process" NARROW [] synonym: "negative regulation of cellular physiological process" EXACT [] is_a: GO:0048519 ! negative regulation of biological process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009987 ! cellular process relationship: negatively_regulates GO:0009987 ! cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0048583 name: regulation of response to stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus." [GOC:jid] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: gosubset_prok is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0050896 ! response to stimulus relationship: regulates GO:0050896 ! response to stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0048589 name: developmental growth namespace: biological_process def: "The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another." [GOC:go_curators] is_a: GO:0040007 ! growth is_a: GO:0044767 ! single-organism developmental process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0048608 name: reproductive structure development namespace: biological_process def: "The reproductive developmental process whose specific outcome is the progression of structures that will be used in the process of creating new individuals from one or more parents, from their formation to the mature structures." [GOC:dph, GOC:isa_complete, GOC:jid] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0061458 ! reproductive system development property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0048638 name: regulation of developmental growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of developmental growth." [GOC:go_curators] is_a: GO:0040008 ! regulation of growth is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0048589 ! developmental growth relationship: regulates GO:0048589 ! developmental growth property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0048639 name: positive regulation of developmental growth namespace: biological_process def: "Any process that activates, maintains or increases the rate of developmental growth." [GOC:go_curators] synonym: "activation of developmental growth" NARROW [] synonym: "stimulation of developmental growth" NARROW [] synonym: "up regulation of developmental growth" EXACT [] synonym: "up-regulation of developmental growth" EXACT [] synonym: "upregulation of developmental growth" EXACT [] is_a: GO:0045927 ! positive regulation of growth is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0051094 ! positive regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0048589 ! developmental growth relationship: positively_regulates GO:0048589 ! developmental growth property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0048646 name: anatomical structure formation involved in morphogenesis namespace: biological_process def: "The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:jid, GOC:tb] comment: Note that, for example, the formation of a pseudopod in an amoeba would not be considered formation involved in morphogenesis because it would not be thought of as the formation of an anatomical structure that was part of the shaping of the amoeba during its development. The formation of an axon from a neuron would be considered the formation of an anatomical structure involved in morphogenesis because it contributes to the creation of the form of the neuron in a developmental sense. subset: goslim_chembl subset: goslim_generic synonym: "formation of an anatomical structure involved in morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0032502 ! developmental process relationship: part_of GO:0009653 ! anatomical structure morphogenesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0048731 name: system development namespace: biological_process def: "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007275 ! multicellular organismal development property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0048856 name: anatomical structure development namespace: biological_process def: "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. subset: goslim_chembl subset: goslim_generic synonym: "development of an anatomical structure" EXACT [] is_a: GO:0032502 ! developmental process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0048869 name: cellular developmental process namespace: biological_process def: "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete] subset: gosubset_prok is_a: GO:0044763 ! single-organism cellular process is_a: GO:0044767 ! single-organism developmental process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0048872 name: homeostasis of number of cells namespace: biological_process def: "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells." [GOC:isa_complete] synonym: "cell population homeostasis" EXACT [] synonym: "homeostasis of cell number" EXACT [GOC:dph] is_a: GO:0042592 ! homeostatic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0048874 name: homeostasis of number of cells in a free-living population namespace: biological_process def: "The biological process involved in maintaining the steady-state number of cells within a population of free-living cells such as the bacteria in the gut." [GOC:isa_complete] subset: gosubset_prok is_a: GO:0044764 ! multi-organism cellular process is_a: GO:0048872 ! homeostasis of number of cells property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0048878 name: chemical homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state of a chemical." [GOC:isa_complete] subset: gosubset_prok is_a: GO:0042592 ! homeostatic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0050000 name: chromosome localization namespace: biological_process def: "Any process in which a chromosome is transported to, or maintained in, a specific location." [GOC:ai] synonym: "chromosome localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of chromosome localization" EXACT [] synonym: "establishment and maintenance of chromosome position" EXACT [] is_a: GO:0051640 ! organelle localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0050072 name: m7G(5')pppN diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide." [EC:3.6.1.30, MetaCyc:M7G5PPPN-PYROPHOSPHATASE-RXN] synonym: "7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [EC:3.6.1.30] synonym: "decapase activity" RELATED [EC:3.6.1.30] synonym: "M(7)G(5')pppN pyrophosphatase activity" EXACT [] synonym: "m7G(5')pppN pyrophosphatase activity" EXACT [EC:3.6.1.30] xref: EC:3.6.1.30 xref: MetaCyc:M7G5PPPN-PYROPHOSPHATASE-RXN is_a: GO:0016462 ! pyrophosphatase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0050136 name: NADH dehydrogenase (quinone) activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol." [EC:1.6.99.5, GOC:mah, MetaCyc:NADH-DEHYDROGENASE-QUINONE-RXN] subset: gosubset_prok synonym: "D-diaphorase activity" EXACT [EC:1.6.99.5] synonym: "DPNH-menadione reductase activity" EXACT [EC:1.6.99.5] synonym: "NADH-quinone oxidoreductase activity" EXACT [EC:1.6.99.5] synonym: "NADH:(quinone-acceptor) oxidoreductase activity" EXACT [EC:1.6.99.5] synonym: "reduced nicotinamide adenine dinucleotide (quinone) dehydrogenase activity" EXACT [EC:1.6.99.5] xref: EC:1.6.99.5 xref: MetaCyc:NADH-DEHYDROGENASE-QUINONE-RXN is_a: GO:0003954 ! NADH dehydrogenase activity is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0050236 name: pyridoxine:NADP 4-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADP(+) + pyridoxine = H(+) + NADPH + pyridoxal." [EC:1.1.1.65, RHEA:16132] synonym: "PL reductase activity" EXACT [EC:1.1.1.65] synonym: "pyridoxal reductase activity" EXACT [EC:1.1.1.65] synonym: "pyridoxin dehydrogenase activity" EXACT [EC:1.1.1.65] synonym: "pyridoxine dehydrogenase activity" EXACT [EC:1.1.1.65] synonym: "pyridoxine:NADP 4-oxidoreductase activity" EXACT [EC:1.1.1.65] synonym: "pyridoxol dehydrogenase activity" EXACT [EC:1.1.1.65] xref: EC:1.1.1.65 xref: KEGG:R01708 xref: MetaCyc:PYRIDOXINE-4-DEHYDROGENASE-RXN xref: RHEA:16132 is_a: GO:0004033 ! aldo-keto reductase (NADP) activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0050265 name: RNA uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UTP + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.52, MetaCyc:RNA-URIDYLYLTRANSFERASE-RXN] synonym: "poly(U) polymerase activity" EXACT [GOC:dph, GOC:mah] synonym: "polynucleotide uridylyltransferase activity" EXACT [GOC:dph, GOC:mah] synonym: "terminal uridylyltransferase activity" EXACT [EC:2.7.7.52] synonym: "TUT activity" EXACT [EC:2.7.7.52] synonym: "UTP:RNA uridylyltransferase activity" EXACT [] xref: EC:2.7.7.52 xref: MetaCyc:RNA-URIDYLYLTRANSFERASE-RXN is_a: GO:0070569 ! uridylyltransferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0050355 name: triphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + triphosphate = diphosphate + phosphate." [EC:3.6.1.25, RHEA:14160] subset: gosubset_prok synonym: "inorganic triphosphatase activity" EXACT [EC:3.6.1.25] synonym: "triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.25] synonym: "tripolyphosphatase activity" EXACT [PMID:24004165] xref: EC:3.6.1.25 xref: KEGG:R00138 xref: MetaCyc:TRIPHOSPHATASE-RXN xref: RHEA:14160 is_a: GO:0016462 ! pyrophosphatase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0050657 name: nucleic acid transport namespace: biological_process def: "The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, ISBN:0198506732] subset: gosubset_prok is_a: GO:0015931 ! nucleobase-containing compound transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0050658 name: RNA transport namespace: biological_process def: "The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0050657 ! nucleic acid transport is_a: GO:0051236 ! establishment of RNA localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0050664 name: oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule." [EC:1.6.3.-] synonym: "oxidoreductase activity, acting on NADH or NADPH, oxygen as acceptor" RELATED [] xref: EC:1.6.3 is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0050789 name: regulation of biological process namespace: biological_process alt_id: GO:0050791 def: "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators] subset: goslim_aspergillus subset: goslim_candida subset: gosubset_prok synonym: "regulation of physiological process" EXACT [] is_a: GO:0065007 ! biological regulation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0008150 ! biological_process relationship: regulates GO:0008150 ! biological_process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0050790 name: regulation of catalytic activity namespace: biological_process def: "Any process that modulates the activity of an enzyme." [GOC:ai] subset: goslim_chembl subset: gosubset_prok synonym: "regulation of enzyme activity" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0003824 ! catalytic activity relationship: regulates GO:0003824 ! catalytic activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0050793 name: regulation of developmental process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators] subset: gosubset_prok is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0032502 ! developmental process relationship: regulates GO:0032502 ! developmental process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0050794 name: regulation of cellular process namespace: biological_process alt_id: GO:0051244 def: "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of cellular physiological process" EXACT [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009987 ! cellular process relationship: regulates GO:0009987 ! cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0050826 name: response to freezing namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius." [GOC:jl] subset: gosubset_prok synonym: "antifreeze activity" RELATED [] synonym: "ice nucleation inhibitor activity" RELATED [] is_a: GO:0009409 ! response to cold property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0050896 name: response to stimulus namespace: biological_process alt_id: GO:0051869 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_pir subset: gosubset_prok synonym: "physiological response to stimulus" EXACT [] is_a: GO:0008150 ! biological_process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051015 name: actin filament binding namespace: molecular_function def: "Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732] synonym: "actin cross-linking activity" RELATED [] synonym: "F-actin binding" EXACT [] is_a: GO:0003779 ! actin binding is_a: GO:0032403 ! protein complex binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051017 name: actin filament bundle assembly namespace: biological_process alt_id: GO:0045011 def: "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai] synonym: "actin bundling activity" RELATED [] synonym: "actin cable assembly" RELATED [GOC:mah] synonym: "actin cable formation" RELATED [GOC:mah] is_a: GO:0022607 ! cellular component assembly is_a: GO:0061572 ! actin filament bundle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051028 name: mRNA transport namespace: biological_process def: "The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0050658 ! RNA transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051052 name: regulation of DNA metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] subset: goslim_yeast subset: gosubset_prok synonym: "regulation of DNA metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006259 ! DNA metabolic process relationship: regulates GO:0006259 ! DNA metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051053 name: negative regulation of DNA metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] subset: gosubset_prok synonym: "down regulation of DNA metabolic process" EXACT [] synonym: "down-regulation of DNA metabolic process" EXACT [] synonym: "downregulation of DNA metabolic process" EXACT [] synonym: "inhibition of DNA metabolic process" NARROW [] synonym: "negative regulation of DNA metabolism" EXACT [] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process is_a: GO:0051052 ! regulation of DNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006259 ! DNA metabolic process relationship: negatively_regulates GO:0006259 ! DNA metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051054 name: positive regulation of DNA metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai] subset: gosubset_prok synonym: "activation of DNA metabolic process" NARROW [] synonym: "positive regulation of DNA metabolism" EXACT [] synonym: "stimulation of DNA metabolic process" NARROW [] synonym: "up regulation of DNA metabolic process" EXACT [] synonym: "up-regulation of DNA metabolic process" EXACT [] synonym: "upregulation of DNA metabolic process" EXACT [] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process is_a: GO:0051052 ! regulation of DNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006259 ! DNA metabolic process relationship: positively_regulates GO:0006259 ! DNA metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051077 name: secondary cell septum namespace: cellular_component def: "Cell wall structures composed of linear polysaccharides which are deposited at both sides of the primary septum at 90 degrees to the primary septum." [GOC:mtg_sensu, PMID:15194814] synonym: "secondary septum" BROAD [] is_a: GO:0030428 ! cell septum property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051094 name: positive regulation of developmental process namespace: biological_process def: "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai] subset: gosubset_prok synonym: "activation of developmental process" NARROW [] synonym: "stimulation of developmental process" NARROW [] synonym: "up regulation of developmental process" EXACT [] synonym: "up-regulation of developmental process" EXACT [] synonym: "upregulation of developmental process" EXACT [] is_a: GO:0048518 ! positive regulation of biological process is_a: GO:0050793 ! regulation of developmental process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0032502 ! developmental process relationship: positively_regulates GO:0032502 ! developmental process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051128 name: regulation of cellular component organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] subset: gosubset_prok synonym: "regulation of cell organisation" RELATED [GOC:mah] synonym: "regulation of cell organization" RELATED [GOC:mah] synonym: "regulation of cellular component organisation" EXACT [GOC:curators] synonym: "regulation of cellular component organization and biogenesis" RELATED [GOC:mah] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016043 ! cellular component organization relationship: regulates GO:0016043 ! cellular component organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051129 name: negative regulation of cellular component organization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] subset: gosubset_prok synonym: "down regulation of cell organization" EXACT [] synonym: "down-regulation of cell organization" EXACT [] synonym: "downregulation of cell organization" EXACT [] synonym: "inhibition of cell organization" NARROW [] synonym: "negative regulation of cell organisation" RELATED [GOC:mah] synonym: "negative regulation of cellular component organization and biogenesis" RELATED [GOC:mah] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0016043 ! cellular component organization relationship: negatively_regulates GO:0016043 ! cellular component organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051130 name: positive regulation of cellular component organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai] synonym: "activation of cell organization" NARROW [] synonym: "positive regulation of cell organisation" EXACT [] synonym: "positive regulation of cellular component organization and biogenesis" RELATED [GOC:mah] synonym: "stimulation of cell organization" NARROW [] synonym: "up regulation of cell organization" EXACT [] synonym: "up-regulation of cell organization" EXACT [] synonym: "upregulation of cell organization" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051128 ! regulation of cellular component organization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0016043 ! cellular component organization relationship: positively_regulates GO:0016043 ! cellular component organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051168 name: nuclear export namespace: biological_process def: "The directed movement of substances out of the nucleus." [GOC:ai] synonym: "export from nucleus" EXACT [] synonym: "nucleus export" EXACT [] synonym: "substance nuclear export" EXACT [] xref: Reactome:REACT_10069 "Nuclear export of snRNA transcripts, Homo sapiens" xref: Reactome:REACT_103510 "Nuclear export of snRNA transcripts, Xenopus tropicalis" xref: Reactome:REACT_112801 "Nuclear export of snRNA transcripts, Drosophila melanogaster" xref: Reactome:REACT_113944 "Nuclear export of snRNA transcripts, Danio rerio" xref: Reactome:REACT_31254 "Nuclear export of snRNA transcripts, Canis familiaris" xref: Reactome:REACT_83378 "Nuclear export of snRNA transcripts, Gallus gallus" xref: Reactome:REACT_89070 "Nuclear export of snRNA transcripts, Taeniopygia guttata" xref: Reactome:REACT_92337 "Nuclear export of snRNA transcripts, Rattus norvegicus" xref: Reactome:REACT_92521 "Nuclear export of snRNA transcripts, Sus scrofa" xref: Reactome:REACT_92868 "Nuclear export of snRNA transcripts, Mus musculus" xref: Reactome:REACT_96465 "Nuclear export of snRNA transcripts, Bos taurus" is_a: GO:0006913 ! nucleocytoplasmic transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051169 name: nuclear transport namespace: biological_process def: "The directed movement of substances into, out of, or within the nucleus." [GOC:ai] subset: goslim_yeast synonym: "nucleus transport" EXACT [] xref: Reactome:REACT_9004 "Import of PIC to the Host Nucleus, Homo sapiens" xref: Wikipedia:Nuclear_transport is_a: GO:0046907 ! intracellular transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051170 name: nuclear import namespace: biological_process def: "The directed movement of substances into the nucleus." [GOC:ai] synonym: "import into nucleus" EXACT [] synonym: "nucleus import" EXACT [] synonym: "substance nuclear import" EXACT [] xref: Reactome:REACT_10010 "snRNP nuclear import and release, Homo sapiens" xref: Reactome:REACT_32050 "snRNP nuclear import and release, Xenopus tropicalis" xref: Reactome:REACT_91459 "snRNP nuclear import and release, Mus musculus" xref: Reactome:REACT_97007 "snRNP nuclear import and release, Danio rerio" is_a: GO:0006913 ! nucleocytoplasmic transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051171 name: regulation of nitrogen compound metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb] subset: gosubset_prok synonym: "regulation of nitrogen metabolic process" EXACT [GOC:tb] synonym: "regulation of nitrogen metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006807 ! nitrogen compound metabolic process relationship: regulates GO:0006807 ! nitrogen compound metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051172 name: negative regulation of nitrogen compound metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb] synonym: "down regulation of nitrogen metabolic process" EXACT [] synonym: "down-regulation of nitrogen metabolic process" EXACT [] synonym: "downregulation of nitrogen metabolic process" EXACT [] synonym: "inhibition of nitrogen metabolic process" NARROW [] synonym: "negative regulation of nitrogen metabolic process" EXACT [GOC:tb] synonym: "negative regulation of nitrogen metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006807 ! nitrogen compound metabolic process relationship: negatively_regulates GO:0006807 ! nitrogen compound metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051173 name: positive regulation of nitrogen compound metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb] synonym: "activation of nitrogen metabolic process" NARROW [] synonym: "positive regulation of nitrogen metabolic process" EXACT [GOC:tb] synonym: "positive regulation of nitrogen metabolism" EXACT [] synonym: "stimulation of nitrogen metabolic process" NARROW [] synonym: "up regulation of nitrogen metabolic process" EXACT [] synonym: "up-regulation of nitrogen metabolic process" EXACT [] synonym: "upregulation of nitrogen metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006807 ! nitrogen compound metabolic process relationship: positively_regulates GO:0006807 ! nitrogen compound metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051174 name: regulation of phosphorus metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai] subset: gosubset_prok synonym: "regulation of phosphorus metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006793 ! phosphorus metabolic process relationship: regulates GO:0006793 ! phosphorus metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051177 name: meiotic sister chromatid cohesion namespace: biological_process def: "The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis." [GOC:ai] is_a: GO:0007062 ! sister chromatid cohesion is_a: GO:0070192 ! chromosome organization involved in meiosis relationship: part_of GO:0045144 ! meiotic sister chromatid segregation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051179 name: localization namespace: biological_process def: "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to or maintained in a specific location." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "establishment and maintenance of cellular component location" NARROW [] synonym: "establishment and maintenance of localization" EXACT [] synonym: "establishment and maintenance of position" EXACT [] synonym: "establishment and maintenance of substance location" NARROW [] synonym: "establishment and maintenance of substrate location" NARROW [] synonym: "localisation" EXACT [GOC:mah] is_a: GO:0008150 ! biological_process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051180 name: vitamin transport namespace: biological_process def: "The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "vitamin or cofactor transport" BROAD [] is_a: GO:0044765 ! single-organism transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051181 name: cofactor transport namespace: biological_process def: "The directed movement of a cofactor into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "vitamin or cofactor transport" BROAD [] is_a: GO:0044765 ! single-organism transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051186 name: cofactor metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [GOC:ai] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "cofactor metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051188 name: cofactor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein." [GOC:ai] subset: gosubset_prok synonym: "cofactor anabolism" EXACT [] synonym: "cofactor biosynthesis" EXACT [] synonym: "cofactor formation" EXACT [] synonym: "cofactor synthesis" EXACT [] is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0051186 ! cofactor metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051213 name: dioxygenase activity namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products." [DOI:10.1016/S0040-4020(03)00944-X, GOC:bf, http://www.onelook.com/] subset: goslim_pir subset: gosubset_prok is_a: GO:0016491 ! oxidoreductase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051225 name: spindle assembly namespace: biological_process alt_id: GO:0051226 alt_id: GO:0051227 def: "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb] synonym: "bipolar spindle biosynthesis" EXACT [] synonym: "bipolar spindle formation" EXACT [] synonym: "spindle biosynthesis" EXACT [] synonym: "spindle formation" EXACT [] is_a: GO:0006461 ! protein complex assembly is_a: GO:0007051 ! spindle organization is_a: GO:0070925 ! organelle assembly property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051228 name: mitotic spindle disassembly namespace: biological_process def: "The controlled breakdown of the spindle during a mitotic cell cycle." [GOC:ai] synonym: "mitotic spindle breakdown" EXACT [] synonym: "mitotic spindle catabolism" EXACT [] synonym: "mitotic spindle degradation" EXACT [] synonym: "spindle breakdown during mitosis" EXACT [] synonym: "spindle degradation during mitosis" EXACT [] synonym: "spindle disassembly during mitosis" EXACT [] is_a: GO:0007052 ! mitotic spindle organization is_a: GO:0051230 ! spindle disassembly intersection_of: GO:0051230 ! spindle disassembly intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000278 ! mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051230 name: spindle disassembly namespace: biological_process def: "The controlled breakdown of the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai] synonym: "spindle breakdown" EXACT [] synonym: "spindle catabolism" EXACT [] synonym: "spindle degradation" EXACT [] is_a: GO:0007051 ! spindle organization is_a: GO:0043241 ! protein complex disassembly is_a: GO:1903008 ! organelle disassembly property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051231 name: spindle elongation namespace: biological_process def: "The cell cycle process in which the distance is lengthened between poles of the spindle." [GOC:ai] is_a: GO:0007017 ! microtubule-based process is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007051 ! spindle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051233 name: spindle midzone namespace: cellular_component def: "The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749] synonym: "central spindle" EXACT [PMID:14528012] synonym: "spindle equator" EXACT [] is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0005819 ! spindle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051234 name: establishment of localization namespace: biological_process def: "The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "establishment of localisation" EXACT [GOC:mah] is_a: GO:0051179 ! localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051235 name: maintenance of location namespace: biological_process def: "Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb] subset: gosubset_prok synonym: "retention" NARROW [] synonym: "sequestering" NARROW [] synonym: "storage" NARROW [] is_a: GO:0051179 ! localization is_a: GO:0065008 ! regulation of biological quality property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051236 name: establishment of RNA localization namespace: biological_process def: "The directed movement of RNA to a specific location." [GOC:ai] synonym: "establishment of RNA localisation" EXACT [GOC:mah] synonym: "RNA positioning" EXACT [] synonym: "RNA recruitment" EXACT [] is_a: GO:0051234 ! establishment of localization relationship: part_of GO:0006403 ! RNA localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051246 name: regulation of protein metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] subset: gosubset_prok synonym: "regulation of protein metabolism" EXACT [] is_a: GO:0060255 ! regulation of macromolecule metabolic process is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0019538 ! protein metabolic process relationship: regulates GO:0019538 ! protein metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051247 name: positive regulation of protein metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai] subset: gosubset_prok synonym: "activation of protein metabolic process" NARROW [] synonym: "positive regulation of protein metabolism" EXACT [] synonym: "stimulation of protein metabolic process" NARROW [] synonym: "up regulation of protein metabolic process" EXACT [] synonym: "up-regulation of protein metabolic process" EXACT [] synonym: "upregulation of protein metabolic process" EXACT [] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0019538 ! protein metabolic process relationship: positively_regulates GO:0019538 ! protein metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051248 name: negative regulation of protein metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai] subset: gosubset_prok synonym: "down regulation of protein metabolic process" EXACT [] synonym: "down-regulation of protein metabolic process" EXACT [] synonym: "downregulation of protein metabolic process" EXACT [] synonym: "inhibition of protein metabolic process" NARROW [] synonym: "negative regulation of protein metabolism" EXACT [] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0051246 ! regulation of protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0019538 ! protein metabolic process relationship: negatively_regulates GO:0019538 ! protein metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051252 name: regulation of RNA metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] subset: gosubset_prok synonym: "regulation of RNA metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016070 ! RNA metabolic process relationship: regulates GO:0016070 ! RNA metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051253 name: negative regulation of RNA metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] subset: gosubset_prok synonym: "down regulation of RNA metabolic process" EXACT [] synonym: "down-regulation of RNA metabolic process" EXACT [] synonym: "downregulation of RNA metabolic process" EXACT [] synonym: "inhibition of RNA metabolic process" NARROW [] synonym: "negative regulation of RNA metabolism" EXACT [] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0016070 ! RNA metabolic process relationship: negatively_regulates GO:0016070 ! RNA metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051254 name: positive regulation of RNA metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai] subset: gosubset_prok synonym: "activation of RNA metabolic process" NARROW [] synonym: "positive regulation of RNA metabolism" EXACT [] synonym: "stimulation of RNA metabolic process" NARROW [] synonym: "up regulation of RNA metabolic process" EXACT [] synonym: "up-regulation of RNA metabolic process" EXACT [] synonym: "upregulation of RNA metabolic process" EXACT [] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0016070 ! RNA metabolic process relationship: positively_regulates GO:0016070 ! RNA metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051255 name: spindle midzone assembly namespace: biological_process def: "The cell cycle process in which aggregation, arrangement and bonding together of a set of components to form the spindle midzone. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749] synonym: "spindle midzone biogenesis" EXACT [] synonym: "spindle midzone biosynthesis" EXACT [] synonym: "spindle midzone formation" EXACT [] is_a: GO:0007017 ! microtubule-based process is_a: GO:0022402 ! cell cycle process is_a: GO:0022607 ! cellular component assembly relationship: part_of GO:0051225 ! spindle assembly property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051256 name: mitotic spindle midzone assembly namespace: biological_process def: "The cell cycle process, occurring during anaphase, in which the aggregation, arrangement and bonding together of a set of components forms the spindle midzone." [GOC:mtg_cell_cycle, GOC:vw] synonym: "mitotic spindle midzone biogenesis" EXACT [] synonym: "mitotic spindle midzone biosynthesis" EXACT [] synonym: "mitotic spindle midzone formation" EXACT [] synonym: "spindle midzone assembly involved in mitosis" EXACT [] synonym: "spindle midzone biogenesis involved in mitosis" EXACT [] synonym: "spindle midzone formation involved in mitosis" EXACT [] is_a: GO:0051255 ! spindle midzone assembly is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0051255 ! spindle midzone assembly intersection_of: part_of GO:0007067 ! mitotic nuclear division relationship: part_of GO:0000022 ! mitotic spindle elongation relationship: part_of GO:0007067 ! mitotic nuclear division relationship: part_of GO:0090307 ! mitotic spindle assembly property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051258 name: protein polymerization namespace: biological_process def: "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "protein polymer biosynthesis" EXACT [] synonym: "protein polymer biosynthetic process" EXACT [] synonym: "protein polymer formation" EXACT [] is_a: GO:0043623 ! cellular protein complex assembly property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051261 name: protein depolymerization namespace: biological_process def: "The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "protein polymer breakdown" EXACT [] synonym: "protein polymer catabolic process" EXACT [] synonym: "protein polymer catabolism" EXACT [] synonym: "protein polymer degradation" EXACT [] is_a: GO:0043624 ! cellular protein complex disassembly property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051276 name: chromosome organization namespace: biological_process alt_id: GO:0007001 alt_id: GO:0051277 def: "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: gosubset_prok synonym: "chromosome organisation" EXACT [] synonym: "chromosome organization and biogenesis" RELATED [GOC:mah] synonym: "maintenance of genome integrity" RELATED [] synonym: "nuclear genome maintenance" RELATED [] is_a: GO:0006996 ! organelle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051286 name: cell tip namespace: cellular_component def: "The region at either end of the longest axis of a cylindrical or elongated cell." [GOC:ai, GOC:mah] comment: Note that this term differs from 'cell pole ; GO:0060187' in that it is applicable to a narrower range of cell shapes. synonym: "cell end" EXACT [GOC:mah] is_a: GO:0060187 ! cell pole property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051300 name: spindle pole body organization namespace: biological_process alt_id: GO:0051426 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle pole body (SPB). The SPB is the microtubule organizing center in fungi, and is functionally homologous to the animal cell centrosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "SPB maturation" RELATED [GOC:vw] synonym: "SPB organization" EXACT [] synonym: "spindle pole body maturation" RELATED [GOC:vw] synonym: "spindle pole body organisation" EXACT [GOC:curators] synonym: "spindle pole body organization and biogenesis" RELATED [GOC:mah] is_a: GO:0022402 ! cell cycle process is_a: GO:0031023 ! microtubule organizing center organization is_a: GO:0071822 ! protein complex subunit organization is_a: GO:1902589 ! single-organism organelle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051301 name: cell division namespace: biological_process def: "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr] comment: Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division. subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: gosubset_prok xref: Wikipedia:Cell_division is_a: GO:0044763 ! single-organism cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051302 name: regulation of cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells." [GOC:go_curators] subset: gosubset_prok is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0051301 ! cell division relationship: regulates GO:0051301 ! cell division property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051303 name: establishment of chromosome localization namespace: biological_process def: "The directed movement of a chromosome to a specific location." [GOC:ai] synonym: "chromosome positioning" EXACT [] synonym: "establishment of chromosome localisation" EXACT [GOC:mah] is_a: GO:0050000 ! chromosome localization is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0051656 ! establishment of organelle localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051304 name: chromosome separation namespace: biological_process alt_id: GO:0034500 def: "The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II)." [GOC:ai, GOC:lb, GOC:mah, GOC:mtg_cell_cycle, PMID:20352243] synonym: "chromatid release" RELATED [GOC:lb, GOC:mah, PMID:20352243] synonym: "rDNA separation" NARROW [] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007059 ! chromosome segregation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051306 name: mitotic sister chromatid separation namespace: biological_process def: "The process in which sister chromatids are physically detached from each other during mitosis." [GOC:ai] synonym: "chromosome separation during mitosis" RELATED [] synonym: "mitotic chromosome separation" RELATED [] synonym: "mitotic sister chromatid resolution" EXACT [GOC:mah] synonym: "sister chromatid separation during mitosis" EXACT [] is_a: GO:0051304 ! chromosome separation is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0000070 ! mitotic sister chromatid segregation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051307 name: meiotic chromosome separation namespace: biological_process def: "The process in which chromosomes are physically detached from each other during meiosis." [GOC:ai] synonym: "chromosome separation during meiosis" EXACT [] synonym: "meiotic chromosome resolution" EXACT [GOC:mah] is_a: GO:0051304 ! chromosome separation is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0051304 ! chromosome separation intersection_of: part_of GO:0051321 ! meiotic cell cycle relationship: part_of GO:0045132 ! meiotic chromosome segregation relationship: part_of GO:0051321 ! meiotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051310 name: metaphase plate congression namespace: biological_process def: "The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle." [GOC:ai] synonym: "chromosome congression" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0051303 ! establishment of chromosome localization relationship: part_of GO:0007059 ! chromosome segregation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051311 name: meiotic metaphase plate congression namespace: biological_process def: "The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis." [GOC:ai] synonym: "metaphase plate congression during meiosis" EXACT [] is_a: GO:0051310 ! metaphase plate congression is_a: GO:1902580 ! single-organism cellular localization is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0051310 ! metaphase plate congression intersection_of: part_of GO:0051321 ! meiotic cell cycle relationship: part_of GO:0045132 ! meiotic chromosome segregation relationship: part_of GO:0051321 ! meiotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051315 name: attachment of mitotic spindle microtubules to kinetochore namespace: biological_process alt_id: GO:0051314 def: "The cell cycle process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex during mitosis. During mitosis, the kinetochores of sister chromosomes are situated facing opposite spindle poles and bipolar attachment of the sister chromosomes to the spindle occurs." [GOC:ai, GOC:clt, GOC:dph, GOC:tb] synonym: "attachment of spindle microtubules to kinetochore during mitosis" RELATED [GOC:dph, GOC:tb] synonym: "attachment of spindle microtubules to kinetochore involved in mitosis" EXACT [GOC:dph, GOC:tb] synonym: "attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation" EXACT [] synonym: "attachment of spindle microtubules to mitotic chromosome" EXACT [] synonym: "mitotic bipolar attachment" RELATED [GOC:vw] is_a: GO:0008608 ! attachment of spindle microtubules to kinetochore is_a: GO:1902850 ! microtubule cytoskeleton organization involved in mitosis intersection_of: GO:0008608 ! attachment of spindle microtubules to kinetochore intersection_of: part_of GO:0000070 ! mitotic sister chromatid segregation relationship: part_of GO:0000070 ! mitotic sister chromatid segregation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051316 name: attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation namespace: biological_process alt_id: GO:0051317 def: "The cell cycle process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex contributing to meiotic chromosome segregation." [GOC:ai, GOC:dph, GOC:tb] synonym: "attachment of spindle microtubules to kinetochore during meiosis" RELATED [] synonym: "attachment of spindle microtubules to kinetochore during meiotic chromosome segregation" RELATED [GOC:dph, GOC:tb] synonym: "attachment of spindle microtubules to meiotic chromosome" EXACT [] is_a: GO:0008608 ! attachment of spindle microtubules to kinetochore is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0008608 ! attachment of spindle microtubules to kinetochore intersection_of: part_of GO:0045132 ! meiotic chromosome segregation relationship: part_of GO:0045132 ! meiotic chromosome segregation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051318 name: G1 phase namespace: biological_process def: "The cell cycle 'gap' phase which is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:G1_phase is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0051325 ! interphase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051319 name: G2 phase namespace: biological_process def: "The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis)." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:G2_phase is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0051325 ! interphase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051320 name: S phase namespace: biological_process def: "The cell cycle phase, following G1, during which DNA synthesis takes place." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "S-phase" EXACT [] xref: Wikipedia:S_phase is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0051325 ! interphase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051321 name: meiotic cell cycle namespace: biological_process def: "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai] subset: goslim_yeast synonym: "meiosis" BROAD [] xref: Wikipedia:Meiosis is_a: GO:0007049 ! cell cycle intersection_of: GO:0007049 ! cell cycle intersection_of: has_part GO:0007126 ! meiotic nuclear division relationship: has_part GO:0007126 ! meiotic nuclear division relationship: part_of GO:0000003 ! reproduction property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051322 name: anaphase namespace: biological_process def: "The cell cycle phase, following metaphase, during which the chromosomes separate and migrate towards the poles of the spindle." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:Anaphase is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0000279 ! M phase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051323 name: metaphase namespace: biological_process def: "The cell cycle phase, following prophase or prometaphase in higher eukaryotes, during which chromosomes become aligned on the equatorial plate of the cell." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:Metaphase is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0000279 ! M phase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051324 name: prophase namespace: biological_process def: "The cell cycle phase which is the first stage of M phase of meiosis and mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:Prophase is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0000279 ! M phase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051325 name: interphase namespace: biological_process def: "The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when prophase of meiosis or mitosis begins. During interphase the cell readies itself for meiosis or mitosis and the replication of its DNA occurs." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "karyostasis" EXACT [] synonym: "resting phase" BROAD [] xref: Wikipedia:Interphase is_a: GO:0022403 ! cell cycle phase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051326 name: telophase namespace: biological_process def: "The cell cycle phase which follows anaphase during M phase of mitosis and meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle] comment: note that this term should not be used for direct annotation. if you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic s-phase). to capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:Telophase is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0000279 ! M phase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051328 name: meiotic interphase namespace: biological_process def: "The cell cycle phase which begins after cytokinesis and ends when meiotic prophase begins. Meiotic cells have an interphase after each meiotic division, but only interphase I involves replication of the cell's DNA." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "interphase of meiotic cell cycle" EXACT [] is_a: GO:0051325 ! interphase is_a: GO:0098762 ! meiotic cell cycle phase intersection_of: GO:0051325 ! interphase intersection_of: happens_during GO:0051321 ! meiotic cell cycle relationship: happens_during GO:0051321 ! meiotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051329 name: mitotic interphase namespace: biological_process def: "The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when mitotic prophase begins. During interphase the cell readies itself for mitosis and the replication of its DNA occurs." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "interphase of mitotic cell cycle" EXACT [] is_a: GO:0051325 ! interphase is_a: GO:0098763 ! mitotic cell cycle phase intersection_of: GO:0051325 ! interphase intersection_of: happens_during GO:0000278 ! mitotic cell cycle relationship: happens_during GO:0000278 ! mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051332 name: meiotic S phase namespace: biological_process def: "The cell cycle phase, following G1, during which DNA synthesis takes place as part of a meiotic cell cycle." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "S phase of meiotic cell cycle" EXACT [] synonym: "S-phase of meiotic cell cycle" EXACT [] is_a: GO:0051320 ! S phase is_a: GO:0098762 ! meiotic cell cycle phase relationship: part_of GO:0051328 ! meiotic interphase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051336 name: regulation of hydrolase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [EC:3.-.-.-, GOC:ai] subset: gosubset_prok synonym: "hydrolase regulator" EXACT [] is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016787 ! hydrolase activity relationship: regulates GO:0016787 ! hydrolase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051338 name: regulation of transferase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [EC:2.-.-.-, GOC:ai] comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead. subset: gocheck_do_not_manually_annotate subset: gosubset_prok synonym: "transferase regulator" EXACT [] is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016740 ! transferase activity relationship: regulates GO:0016740 ! transferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051340 name: regulation of ligase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6." [EC:6.-.-.-, GOC:ai] subset: gosubset_prok synonym: "ligase regulator" EXACT [] is_a: GO:0050790 ! regulation of catalytic activity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016874 ! ligase activity relationship: regulates GO:0016874 ! ligase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051345 name: positive regulation of hydrolase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds." [GOC:ai] subset: gosubset_prok synonym: "activation of hydrolase activity" NARROW [] synonym: "hydrolase activator" EXACT [] synonym: "stimulation of hydrolase activity" NARROW [] synonym: "up regulation of hydrolase activity" EXACT [] synonym: "up-regulation of hydrolase activity" EXACT [] synonym: "upregulation of hydrolase activity" EXACT [] is_a: GO:0043085 ! positive regulation of catalytic activity is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0016787 ! hydrolase activity relationship: positively_regulates GO:0016787 ! hydrolase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051347 name: positive regulation of transferase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai] comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead. subset: gocheck_do_not_manually_annotate subset: gosubset_prok synonym: "activation of transferase activity" NARROW [] synonym: "stimulation of transferase activity" NARROW [] synonym: "transferase activator" EXACT [] synonym: "up regulation of transferase activity" EXACT [] synonym: "up-regulation of transferase activity" EXACT [] synonym: "upregulation of transferase activity" EXACT [] is_a: GO:0043085 ! positive regulation of catalytic activity is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0016740 ! transferase activity relationship: positively_regulates GO:0016740 ! transferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051348 name: negative regulation of transferase activity namespace: biological_process def: "Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai] comment: This term is useful for grouping, but is too general for manual annotation. Please use a child term instead. subset: gocheck_do_not_manually_annotate subset: gosubset_prok synonym: "down regulation of transferase activity" EXACT [] synonym: "down-regulation of transferase activity" EXACT [] synonym: "downregulation of transferase activity" EXACT [] synonym: "inhibition of transferase activity" NARROW [] synonym: "transferase inhibitor" EXACT [] is_a: GO:0043086 ! negative regulation of catalytic activity is_a: GO:0051338 ! regulation of transferase activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0016740 ! transferase activity relationship: negatively_regulates GO:0016740 ! transferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051352 name: negative regulation of ligase activity namespace: biological_process def: "Any process that stops or reduces the rate of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:ai] subset: gosubset_prok synonym: "down regulation of ligase activity" EXACT [] synonym: "down-regulation of ligase activity" EXACT [] synonym: "downregulation of ligase activity" EXACT [] synonym: "inhibition of ligase activity" NARROW [] synonym: "ligase inhibitor" EXACT [] is_a: GO:0043086 ! negative regulation of catalytic activity is_a: GO:0051340 ! regulation of ligase activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0016874 ! ligase activity relationship: negatively_regulates GO:0016874 ! ligase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051383 name: kinetochore organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "kinetochore organisation" EXACT [GOC:curators] synonym: "kinetochore organization and biogenesis" RELATED [GOC:mah] is_a: GO:0051276 ! chromosome organization is_a: GO:0071822 ! protein complex subunit organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051409 name: response to nitrosative stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions." [PMID:15925705] is_a: GO:0006950 ! response to stress property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051415 name: interphase microtubule nucleation by interphase microtubule organizing center namespace: biological_process def: "The 'de novo' formation of a microtubule by the interphase microtubule organizing center during interphase, the stage of cell cycle between successive rounds of chromosome segregation." [GOC:ai] synonym: "IMTOC-mediated microtubule nucleation during interphase" EXACT [] synonym: "interphase microtubule nucleation by interphase microtubule organising centre" EXACT [] synonym: "interphase microtubule organizing center-mediated microtubule nucleation during interphase" EXACT [] synonym: "microtubule nucleation during interphase by IMTOC" EXACT [] synonym: "microtubule nucleation during interphase by interphase microtubule organizing center" EXACT [] is_a: GO:0022402 ! cell cycle process is_a: GO:0051418 ! microtubule nucleation by microtubule organizing center property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051418 name: microtubule nucleation by microtubule organizing center namespace: biological_process def: "The 'de novo' formation of a microtubule, mediated by the microtubule organizing center." [GOC:ai] synonym: "microtubule nucleation by microtubule organising centre" EXACT [] synonym: "microtubule nucleation by MTOC" EXACT [] synonym: "microtubule organizing center-mediated microtubule nucleation" EXACT [] synonym: "MTOC-mediated microtubule nucleation" EXACT [] is_a: GO:0007020 ! microtubule nucleation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051436 name: negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin ligase activity that contributes to the mitotic cell cycle." [GOC:ai, GOC:tb] synonym: "anaphase promoting complex inhibition during mitotic cell cycle" NARROW [] synonym: "anaphase-promoting complex inhibition during mitotic cell cycle" NARROW [] synonym: "APC inhibition during mitotic cell cycle" NARROW [] synonym: "down regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [] synonym: "down-regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [] synonym: "downregulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [] synonym: "inhibition of ubiquitin ligase activity during mitotic cell cycle" NARROW [] synonym: "mitotic anaphase promoting complex inhibition" NARROW [] synonym: "mitotic anaphase promoting complex inhibitor" NARROW [] synonym: "mitotic anaphase-promoting complex inhibition" NARROW [] synonym: "mitotic anaphase-promoting complex inhibitor" NARROW [] synonym: "mitotic APC inhibition" NARROW [] synonym: "mitotic APC inhibitor" NARROW [] synonym: "mitotic SCF complex inhibitor" NARROW [] synonym: "mitotic ubiquitin ligase inhibitor" NARROW [] synonym: "negative regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [GOC:tb] synonym: "negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb] xref: Reactome:REACT_100142 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Mus musculus" xref: Reactome:REACT_100445 "Dissociation of phospho-Cdh1 from the APC/C complex, Drosophila melanogaster" xref: Reactome:REACT_101151 "Dissociation of phospho-Cdh1 from the APC/C complex, Gallus gallus" xref: Reactome:REACT_101227 "Association of Emi1 with Cdh1, Sus scrofa" xref: Reactome:REACT_101353 "Autodegradation of Cdh1 by Cdh1:APC/C, Rattus norvegicus" xref: Reactome:REACT_101600 "Autodegradation of Cdh1 by Cdh1:APC/C, Oryza sativa" xref: Reactome:REACT_101893 "Association of Emi1 with Cdh1, Taeniopygia guttata" xref: Reactome:REACT_1041 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Homo sapiens" xref: Reactome:REACT_107016 "Association of Emi1 with Cdc20, Sus scrofa" xref: Reactome:REACT_107407 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Canis familiaris" xref: Reactome:REACT_108334 "Association of Emi1 with Cdh1, Gallus gallus" xref: Reactome:REACT_108949 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Gallus gallus" xref: Reactome:REACT_109419 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Drosophila melanogaster" xref: Reactome:REACT_109619 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Taeniopygia guttata" xref: Reactome:REACT_110332 "Autodegradation of Cdh1 by Cdh1:APC/C, Mus musculus" xref: Reactome:REACT_110505 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Mus musculus" xref: Reactome:REACT_110936 "Autodegradation of Cdh1 by Cdh1:APC/C, Xenopus tropicalis" xref: Reactome:REACT_110945 "Association of Emi1 with Cdc20, Mus musculus" xref: Reactome:REACT_113042 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Saccharomyces cerevisiae" xref: Reactome:REACT_113195 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Arabidopsis thaliana" xref: Reactome:REACT_113808 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Schizosaccharomyces pombe" xref: Reactome:REACT_114563 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Oryza sativa" xref: Reactome:REACT_28043 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Rattus norvegicus" xref: Reactome:REACT_28963 "Association of Emi1 with Cdh1, Xenopus tropicalis" xref: Reactome:REACT_29737 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Bos taurus" xref: Reactome:REACT_30026 "Dissociation of phospho-Cdh1 from the APC/C complex, Arabidopsis thaliana" xref: Reactome:REACT_30516 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Drosophila melanogaster" xref: Reactome:REACT_30857 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Canis familiaris" xref: Reactome:REACT_30946 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Taeniopygia guttata" xref: Reactome:REACT_31067 "Autodegradation of Cdh1 by Cdh1:APC/C, Taeniopygia guttata" xref: Reactome:REACT_31098 "Association of Emi1 with Cdh1, Bos taurus" xref: Reactome:REACT_31143 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Arabidopsis thaliana" xref: Reactome:REACT_31936 "Autodegradation of Cdh1 by Cdh1:APC/C, Gallus gallus" xref: Reactome:REACT_33157 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Mus musculus" xref: Reactome:REACT_33255 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Oryza sativa" xref: Reactome:REACT_33337 "Dissociation of phospho-Cdh1 from the APC/C complex, Danio rerio" xref: Reactome:REACT_33422 "Association of Emi1 with Cdc20, Danio rerio" xref: Reactome:REACT_6721 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Homo sapiens" xref: Reactome:REACT_6745 "Association of Emi1 with Cdc20, Homo sapiens" xref: Reactome:REACT_6773 "Association of Emi1 with Cdh1, Homo sapiens" xref: Reactome:REACT_6785 "Autodegradation of Cdh1 by Cdh1:APC/C, Homo sapiens" xref: Reactome:REACT_6811 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Homo sapiens" xref: Reactome:REACT_6845 "Dissociation of phospho-Cdh1 from the APC/C complex, Homo sapiens" xref: Reactome:REACT_78275 "Association of Emi1 with Cdc20, Bos taurus" xref: Reactome:REACT_81772 "Autodegradation of Cdh1 by Cdh1:APC/C, Bos taurus" xref: Reactome:REACT_81857 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Bos taurus" xref: Reactome:REACT_81918 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Drosophila melanogaster" xref: Reactome:REACT_81946 "Autodegradation of Cdh1 by Cdh1:APC/C, Drosophila melanogaster" xref: Reactome:REACT_82578 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Danio rerio" xref: Reactome:REACT_83000 "Association of Emi1 with Cdc20, Xenopus tropicalis" xref: Reactome:REACT_83890 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Xenopus tropicalis" xref: Reactome:REACT_84020 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Xenopus tropicalis" xref: Reactome:REACT_84061 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Rattus norvegicus" xref: Reactome:REACT_84462 "Dissociation of phospho-Cdh1 from the APC/C complex, Taeniopygia guttata" xref: Reactome:REACT_85360 "Association of Emi1 with Cdh1, Danio rerio" xref: Reactome:REACT_85707 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Canis familiaris" xref: Reactome:REACT_85766 "Dissociation of phospho-Cdh1 from the APC/C complex, Oryza sativa" xref: Reactome:REACT_86349 "Association of Emi1 with Cdh1, Canis familiaris" xref: Reactome:REACT_88500 "Association of Emi1 with Cdh1, Mus musculus" xref: Reactome:REACT_88651 "Autodegradation of Cdh1 by Cdh1:APC/C, Canis familiaris" xref: Reactome:REACT_88799 "Dissociation of phospho-Cdh1 from the APC/C complex, Mus musculus" xref: Reactome:REACT_90365 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Sus scrofa" xref: Reactome:REACT_90596 "Dissociation of phospho-Cdh1 from the APC/C complex, Canis familiaris" xref: Reactome:REACT_91269 "Association of Emi1 with Cdh1, Rattus norvegicus" xref: Reactome:REACT_91998 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Dictyostelium discoideum" xref: Reactome:REACT_92690 "Dissociation of phospho-Cdh1 from the APC/C complex, Rattus norvegicus" xref: Reactome:REACT_93689 "Autodegradation of Cdh1 by Cdh1:APC/C, Danio rerio" xref: Reactome:REACT_93696 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Danio rerio" xref: Reactome:REACT_94003 "Association of Emi1 with Cdc20, Gallus gallus" xref: Reactome:REACT_94092 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Xenopus tropicalis" xref: Reactome:REACT_95146 "Dissociation of phospho-Cdh1 from the APC/C complex, Xenopus tropicalis" xref: Reactome:REACT_96413 "Association of Emi1 with Cdc20, Canis familiaris" xref: Reactome:REACT_96435 "Association of Emi1 with Cdc20, Taeniopygia guttata" xref: Reactome:REACT_96450 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Rattus norvegicus" xref: Reactome:REACT_98168 "Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, Danio rerio" xref: Reactome:REACT_98605 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2, Bos taurus" xref: Reactome:REACT_99005 "Phosphorylation of Cdh1 by Cyclin A:Cdk2, Gallus gallus" xref: Reactome:REACT_99200 "Dissociation of phospho-Cdh1 from the APC/C complex, Bos taurus" xref: Reactome:REACT_99420 "Association of Emi1 with Cdc20, Rattus norvegicus" is_a: GO:0051439 ! regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle is_a: GO:0051444 ! negative regulation of ubiquitin-protein transferase activity intersection_of: GO:0051444 ! negative regulation of ubiquitin-protein transferase activity intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000278 ! mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051438 name: regulation of ubiquitin-protein transferase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ubiquitin transferase activity." [GOC:ai, GOC:tb] synonym: "anaphase-promoting complex regulator" NARROW [] synonym: "APC regulator" NARROW [] synonym: "regulation of ubiquitin transferase activity" EXACT [GOC:tb] synonym: "SCF complex regulator" NARROW [] synonym: "ubiquitin transferase regulator" RELATED [] synonym: "ubiquitin-protein transferase regulator" RELATED [] is_a: GO:0031396 ! regulation of protein ubiquitination is_a: GO:0051338 ! regulation of transferase activity is_a: GO:0051340 ! regulation of ligase activity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0004842 ! ubiquitin-protein transferase activity relationship: regulates GO:0004842 ! ubiquitin-protein transferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051439 name: regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle namespace: biological_process def: "A cell cycle process that modulates the frequency, rate or extent of ubiquitin ligase activity that contributes to the mitotic cell cycle." [GOC:ai] synonym: "mitotic anaphase-promoting complex regulator" NARROW [] synonym: "mitotic APC regulator" NARROW [] synonym: "mitotic SCF complex regulator" NARROW [] synonym: "mitotic ubiquitin ligase regulator" RELATED [] synonym: "mitotic ubiquitin-protein ligase regulator" RELATED [] synonym: "regulation of ubiquitin ligase activity during mitotic cell cycle" RELATED [GOC:tb] synonym: "regulation of ubiquitin-protein ligase activity during mitotic cell cycle" RELATED [GOC:dph, GOC:tb] xref: Reactome:REACT_101451 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Gallus gallus" xref: Reactome:REACT_102310 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Xenopus tropicalis" xref: Reactome:REACT_105248 "Regulation of APC/C activators between G1/S and early anaphase, Oryza sativa" xref: Reactome:REACT_106660 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Arabidopsis thaliana" xref: Reactome:REACT_106902 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Oryza sativa" xref: Reactome:REACT_109987 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Taeniopygia guttata" xref: Reactome:REACT_114183 "Regulation of APC/C activators between G1/S and early anaphase, Saccharomyces cerevisiae" xref: Reactome:REACT_28152 "Regulation of APC/C activators between G1/S and early anaphase, Drosophila melanogaster" xref: Reactome:REACT_29664 "Regulation of APC/C activators between G1/S and early anaphase, Dictyostelium discoideum" xref: Reactome:REACT_32993 "Regulation of APC/C activators between G1/S and early anaphase, Bos taurus" xref: Reactome:REACT_6837 "Regulation of APC/C activators between G1/S and early anaphase, Homo sapiens" xref: Reactome:REACT_6867 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Homo sapiens" xref: Reactome:REACT_79510 "Regulation of APC/C activators between G1/S and early anaphase, Schizosaccharomyces pombe" xref: Reactome:REACT_79637 "Regulation of APC/C activators between G1/S and early anaphase, Rattus norvegicus" xref: Reactome:REACT_81889 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Schizosaccharomyces pombe" xref: Reactome:REACT_82881 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Canis familiaris" xref: Reactome:REACT_84326 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Danio rerio" xref: Reactome:REACT_85472 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Sus scrofa" xref: Reactome:REACT_86217 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Rattus norvegicus" xref: Reactome:REACT_86939 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Mus musculus" xref: Reactome:REACT_87214 "Regulation of APC/C activators between G1/S and early anaphase, Mus musculus" xref: Reactome:REACT_90721 "Regulation of APC/C activators between G1/S and early anaphase, Danio rerio" xref: Reactome:REACT_90808 "Regulation of APC/C activators between G1/S and early anaphase, Canis familiaris" xref: Reactome:REACT_93090 "Regulation of APC/C activators between G1/S and early anaphase, Xenopus tropicalis" xref: Reactome:REACT_93672 "Regulation of APC/C activators between G1/S and early anaphase, Gallus gallus" xref: Reactome:REACT_95909 "Regulation of APC/C activators between G1/S and early anaphase, Taeniopygia guttata" xref: Reactome:REACT_96088 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Drosophila melanogaster" xref: Reactome:REACT_97346 "Regulation of APC/C activators between G1/S and early anaphase, Arabidopsis thaliana" xref: Reactome:REACT_97869 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Bos taurus" xref: Reactome:REACT_97959 "Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, Saccharomyces cerevisiae" xref: Reactome:REACT_99134 "Regulation of APC/C activators between G1/S and early anaphase, Sus scrofa" is_a: GO:0051438 ! regulation of ubiquitin-protein transferase activity is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0051438 ! regulation of ubiquitin-protein transferase activity intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000278 ! mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051444 name: negative regulation of ubiquitin-protein transferase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin transferase activity." [GOC:ai, GOC:tb] synonym: "anaphase promoting complex inhibition" NARROW [] synonym: "anaphase promoting complex inhibitor" NARROW [] synonym: "anaphase-promoting complex inhibition" NARROW [] synonym: "anaphase-promoting complex inhibitor" NARROW [] synonym: "APC inhibition" NARROW [] synonym: "APC inhibitor" NARROW [] synonym: "down regulation of ubiquitin transferase activity" EXACT [] synonym: "down-regulation of ubiquitin transferase activity" EXACT [] synonym: "downregulation of ubiquitin transferase activity" EXACT [] synonym: "inhibition of ubiquitin transferase activity" NARROW [] synonym: "negative regulation of ubiquitin transferase activity" EXACT [GOC:tb] synonym: "SCF complex inhibitor" NARROW [] synonym: "ubiquitin transferase inhibitor" NARROW [] is_a: GO:0031397 ! negative regulation of protein ubiquitination is_a: GO:0051348 ! negative regulation of transferase activity is_a: GO:0051352 ! negative regulation of ligase activity is_a: GO:0051438 ! regulation of ubiquitin-protein transferase activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0004842 ! ubiquitin-protein transferase activity relationship: negatively_regulates GO:0004842 ! ubiquitin-protein transferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051445 name: regulation of meiotic cell cycle namespace: biological_process def: "Any process that modulates the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] synonym: "meiotic cell cycle modulation" EXACT [] synonym: "meiotic cell cycle regulation" EXACT [] synonym: "meiotic cell cycle regulator" RELATED [] synonym: "modulation of meiotic cell cycle progression" EXACT [] synonym: "regulation of meiotic cell cycle progression" EXACT [] synonym: "regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0051321 ! meiotic cell cycle relationship: regulates GO:0051321 ! meiotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051447 name: negative regulation of meiotic cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle." [GOC:ai, GOC:dph, GOC:tb] synonym: "down regulation of progression through meiotic cell cycle" EXACT [] synonym: "down-regulation of progression through meiotic cell cycle" EXACT [] synonym: "downregulation of progression through meiotic cell cycle" EXACT [] synonym: "inhibition of progression through meiotic cell cycle" NARROW [] synonym: "negative regulation of meiotic cell cycle progression" EXACT [] synonym: "negative regulation of progression through meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0045786 ! negative regulation of cell cycle is_a: GO:0051445 ! regulation of meiotic cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0051321 ! meiotic cell cycle relationship: negatively_regulates GO:0051321 ! meiotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051455 name: attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation namespace: biological_process def: "The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex during meiosis I. During meiosis I sister kinetochores are lying next to each other facing the same spindle pole and monopolar attachment of the chromatid to the spindle occurs." [GOC:ai, GOC:clt, GOC:dph, GOC:tb] comment: Note that the synonym 'monopolar attachment' refers to the normal attachment of sister chromosomes to the spindle in meiosis I, and not to the aberrant attachment of sister kinetochores to a single pole in mitosis. synonym: "attachment of spindle microtubules to kinetochore during meiosis I" RELATED [GOC:dph, GOC:tb] synonym: "attachment of spindle microtubules to kinetochore involved in meiosis I" EXACT [GOC:dph, GOC:tb] synonym: "monopolar attachment" EXACT [] synonym: "sister kinetochore mono-orientation" EXACT [] is_a: GO:0051316 ! attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation is_a: GO:0090172 ! microtubule cytoskeleton organization involved in homologous chromosome segregation intersection_of: GO:0008608 ! attachment of spindle microtubules to kinetochore intersection_of: part_of GO:0045143 ! homologous chromosome segregation relationship: part_of GO:0045143 ! homologous chromosome segregation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051510 name: regulation of unidimensional cell growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of unidimensional cell growth, the process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis." [GOC:ai] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0022604 ! regulation of cell morphogenesis is_a: GO:0048638 ! regulation of developmental growth intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009826 ! unidimensional cell growth relationship: regulates GO:0009826 ! unidimensional cell growth property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051512 name: positive regulation of unidimensional cell growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of unidimensional cell growth, the process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis." [GOC:ai] synonym: "activation of unidimensional cell growth" NARROW [] synonym: "stimulation of unidimensional cell growth" NARROW [] synonym: "up regulation of unidimensional cell growth" EXACT [] synonym: "up-regulation of unidimensional cell growth" EXACT [] synonym: "upregulation of unidimensional cell growth" EXACT [] is_a: GO:0030307 ! positive regulation of cell growth is_a: GO:0048639 ! positive regulation of developmental growth is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0051510 ! regulation of unidimensional cell growth intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009826 ! unidimensional cell growth relationship: positively_regulates GO:0009826 ! unidimensional cell growth property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051513 name: regulation of monopolar cell growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell." [GOC:ai] is_a: GO:0051510 ! regulation of unidimensional cell growth intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0042814 ! monopolar cell growth relationship: regulates GO:0042814 ! monopolar cell growth property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051515 name: positive regulation of monopolar cell growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of monopolar cell growth, polarized growth from one end of a cell." [GOC:ai] synonym: "stimulation of monopolar cell growth" NARROW [] synonym: "up regulation of monopolar cell growth" EXACT [] synonym: "up-regulation of monopolar cell growth" EXACT [] synonym: "upregulation of monopolar cell growth" EXACT [] is_a: GO:0051512 ! positive regulation of unidimensional cell growth is_a: GO:0051513 ! regulation of monopolar cell growth intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0042814 ! monopolar cell growth relationship: positively_regulates GO:0042814 ! monopolar cell growth property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051516 name: regulation of bipolar cell growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai] is_a: GO:0051510 ! regulation of unidimensional cell growth intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0042815 ! bipolar cell growth relationship: regulates GO:0042815 ! bipolar cell growth property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051518 name: positive regulation of bipolar cell growth namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai] synonym: "stimulation of bipolar cell growth" NARROW [] synonym: "up regulation of bipolar cell growth" EXACT [] synonym: "up-regulation of bipolar cell growth" EXACT [] synonym: "upregulation of bipolar cell growth" EXACT [] is_a: GO:0051512 ! positive regulation of unidimensional cell growth is_a: GO:0051516 ! regulation of bipolar cell growth intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0042815 ! bipolar cell growth relationship: positively_regulates GO:0042815 ! bipolar cell growth property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051519 name: activation of bipolar cell growth namespace: biological_process def: "Any process that initiates the inactive process of bipolar cell growth, polarized growth from both ends of a cell." [GOC:ai] synonym: "NETO" EXACT [GOC:mah, GOC:vw] synonym: "new end take off" EXACT [GOC:mah, GOC:vw] is_a: GO:0051518 ! positive regulation of bipolar cell growth property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051522 name: activation of monopolar cell growth namespace: biological_process def: "Any process that initiates the inactive process of monopolar cell growth, polarized growth from one end of a cell." [GOC:ai] is_a: GO:0051515 ! positive regulation of monopolar cell growth property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051536 name: iron-sulfur cluster binding namespace: molecular_function def: "Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms." [GOC:ai] synonym: "Fe/S binding" EXACT [] synonym: "iron sulfur cluster binding" EXACT [] synonym: "iron sulphur cluster binding" EXACT [] synonym: "iron-sulphur cluster binding" EXACT [] is_a: GO:0051540 ! metal cluster binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051540 name: metal cluster binding namespace: molecular_function def: "Interacting selectively and non-covalently with a cluster of atoms including both metal ions and nonmetal atoms, usually sulfur and oxygen. Examples include iron-sulfur clusters and nickel-iron-sulfur clusters." [GOC:jsg] subset: goslim_pir subset: gosubset_prok is_a: GO:0005488 ! binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051567 name: histone H3-K9 methylation namespace: biological_process def: "The modification of histone H3 by addition of a methyl group to lysine at position 9 of the histone." [GOC:ai] synonym: "histone H3 K9 methylation" EXACT [] synonym: "histone H3K9me" EXACT [] synonym: "histone lysine H3 K9 methylation" EXACT [] is_a: GO:0034968 ! histone lysine methylation is_a: GO:0061647 ! histone H3-K9 modification property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051568 name: histone H3-K4 methylation namespace: biological_process def: "The modification of histone H3 by addition of a methyl group to lysine at position 4 of the histone." [GOC:ai] synonym: "histone H3 K4 methylation" EXACT [] synonym: "histone H3K4me" EXACT [] synonym: "histone lysine H3 K4 methylation" EXACT [] is_a: GO:0034968 ! histone lysine methylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051591 name: response to cAMP namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus." [GOC:ai] synonym: "response to 3',5' cAMP" EXACT [] synonym: "response to 3',5'-cAMP" EXACT [] synonym: "response to adenosine 3',5'-cyclophosphate" EXACT [] synonym: "response to cyclic AMP" EXACT [] is_a: GO:0014074 ! response to purine-containing compound is_a: GO:0046683 ! response to organophosphorus is_a: GO:1901700 ! response to oxygen-containing compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051592 name: response to calcium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:ai] synonym: "response to Ca2+ ion" EXACT [] is_a: GO:0010038 ! response to metal ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051595 name: response to methylglyoxal namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. Methylglyoxal is a 2-oxoaldehyde derived from propanal." [GOC:ai] subset: gosubset_prok synonym: "response to pyruvaldehyde" EXACT [] is_a: GO:1901654 ! response to ketone property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051596 name: methylglyoxal catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid." [GOC:ai] subset: gosubset_prok synonym: "methylglyoxal breakdown" EXACT [] synonym: "methylglyoxal catabolism" EXACT [] synonym: "methylglyoxal degradation" EXACT [] xref: MetaCyc:METHGLYUT-PWY xref: MetaCyc:Methylglyoxal-Detoxification is_a: GO:0009438 ! methylglyoxal metabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:0046185 ! aldehyde catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051603 name: proteolysis involved in cellular protein catabolic process namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:ai, GOC:dph, GOC:tb] subset: goslim_yeast subset: gosubset_prok synonym: "peptidolysis during cellular protein catabolic process" RELATED [] synonym: "peptidolysis during cellular protein catabolism" RELATED [] synonym: "peptidolysis involved in cellular protein catabolic process" EXACT [] synonym: "peptidolysis involved in cellular protein catabolism" EXACT [] synonym: "proteolysis during cellular protein catabolic process" RELATED [] synonym: "proteolysis during cellular protein catabolism" RELATED [] is_a: GO:0006508 ! proteolysis intersection_of: GO:0006508 ! proteolysis intersection_of: part_of GO:0044257 ! cellular protein catabolic process relationship: part_of GO:0044257 ! cellular protein catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051604 name: protein maturation namespace: biological_process def: "Any process leading to the attainment of the full functional capacity of a protein." [GOC:ai] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok is_a: GO:0019538 ! protein metabolic process relationship: part_of GO:0010467 ! gene expression property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051606 name: detection of stimulus namespace: biological_process def: "The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal." [GOC:add, GOC:ai, GOC:dph, GOC:mah] subset: goslim_pir subset: gosubset_prok synonym: "perception of stimulus" RELATED [] synonym: "stimulus detection" EXACT [] synonym: "stimulus sensing" RELATED [] is_a: GO:0050896 ! response to stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051640 name: organelle localization namespace: biological_process def: "Any process in which an organelle is transported to, and/or maintained in, a specific location." [GOC:ai] subset: goslim_pir synonym: "establishment and maintenance of organelle localization" EXACT [] synonym: "organelle localisation" EXACT [GOC:mah] is_a: GO:0051641 ! cellular localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051641 name: cellular localization namespace: biological_process def: "A localization process that takes place at the cellular level; as a result of a cellular localization process, a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell." [GOC:ai, GOC:mah] subset: goslim_pir subset: gosubset_prok synonym: "cellular localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of cellular localization" EXACT [] synonym: "establishment and maintenance of localization in cell or cell membrane" EXACT [] synonym: "intracellular localization" NARROW [] synonym: "localization within cell" NARROW [] is_a: GO:0051179 ! localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051643 name: endoplasmic reticulum localization namespace: biological_process def: "Any process in which endoplasmic reticulum is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "endoplasmic reticulum localisation" EXACT [GOC:mah] synonym: "ER localization" EXACT [GOC:dph] synonym: "establishment and maintenance of ER localization" EXACT [] is_a: GO:0051640 ! organelle localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051646 name: mitochondrion localization namespace: biological_process def: "Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "establishment and maintenance of mitochondria localization" EXACT [] synonym: "establishment and maintenance of mitochondrion localization" EXACT [] synonym: "localization of mitochondria" EXACT [] synonym: "localization of mitochondrion" EXACT [] synonym: "mitochondria localization" EXACT [] synonym: "mitochondrial localization" EXACT [] synonym: "mitochondrion localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051647 name: nucleus localization namespace: biological_process def: "Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell." [GOC:ai] synonym: "cell nucleus localization" EXACT [] synonym: "establishment and maintenance of nucleus localization" EXACT [] synonym: "localization of nucleus" EXACT [] synonym: "nucleus localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051649 name: establishment of localization in cell namespace: biological_process def: "The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell." [GOC:ai, GOC:dph, GOC:tb] subset: gosubset_prok synonym: "establishment of cellular localization" RELATED [GOC:dph, GOC:tb] synonym: "establishment of intracellular localization" NARROW [] synonym: "establishment of localisation in cell" EXACT [GOC:mah] synonym: "establishment of localization within cell" NARROW [] synonym: "positioning within cell" NARROW [] is_a: GO:0051234 ! establishment of localization intersection_of: GO:0051234 ! establishment of localization intersection_of: occurs_in GO:0005623 ! cell relationship: occurs_in GO:0005623 ! cell relationship: part_of GO:0051641 ! cellular localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051651 name: maintenance of location in cell namespace: biological_process def: "Any process in which a substance or cellular entity, such as a protein complex or organelle, is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:ai] subset: gosubset_prok synonym: "cellular retention" NARROW [] synonym: "cellular sequestering" NARROW [] synonym: "cellular storage" NARROW [] synonym: "intracellular retention" NARROW [] synonym: "intracellular sequestering" NARROW [] synonym: "intracellular storage" NARROW [] synonym: "maintenance of cellular localization" RELATED [GOC:dph, GOC:tb] synonym: "maintenance of intracellular localization" NARROW [] synonym: "maintenance of localization in cell" RELATED [GOC:dph, GOC:tb] synonym: "maintenance of localization within cell" NARROW [] synonym: "retention within cell" NARROW [] synonym: "sequestering within cell" NARROW [] synonym: "storage within cell" NARROW [] is_a: GO:0044763 ! single-organism cellular process is_a: GO:0051235 ! maintenance of location is_a: GO:1902578 ! single-organism localization relationship: part_of GO:0051641 ! cellular localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051656 name: establishment of organelle localization namespace: biological_process def: "The directed movement of an organelle to a specific location." [GOC:ai] synonym: "establishment of organelle localisation" EXACT [GOC:mah] is_a: GO:0051234 ! establishment of localization relationship: part_of GO:0051640 ! organelle localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051664 name: nuclear pore localization namespace: biological_process def: "Any process in which nuclear pores are transported to, or maintained in, a specific location." [GOC:ai] synonym: "establishment and maintenance of nuclear pore localization" EXACT [] synonym: "nuclear pore localisation" EXACT [GOC:mah] is_a: GO:0034629 ! cellular protein complex localization is_a: GO:0051668 ! localization within membrane property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051666 name: actin cortical patch localization namespace: biological_process def: "Any process in which actin cortical patches are transported to, or maintained in, a specific location. An actin cortical patch is a discrete actin-containing structure found just beneath the plasma membrane in fungal cells." [GOC:mah] synonym: "actin cortical patch localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of actin cortical patch localization" EXACT [] is_a: GO:0051641 ! cellular localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051668 name: localization within membrane namespace: biological_process def: "Any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane." [GOC:ai] subset: gosubset_prok synonym: "establishment and maintenance of localization in membrane" EXACT [] synonym: "establishment and maintenance of position in membrane" EXACT [] synonym: "localisation within membrane" EXACT [GOC:mah] synonym: "localization to membrane" EXACT [] synonym: "positioning within membrane" NARROW [] is_a: GO:0051641 ! cellular localization intersection_of: GO:0051179 ! localization intersection_of: occurs_in GO:0016020 ! membrane relationship: occurs_in GO:0016020 ! membrane property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051704 name: multi-organism process namespace: biological_process alt_id: GO:0051706 def: "A biological process which involves another organism of the same or different species." [GOC:jl] subset: goslim_pir subset: gosubset_prok synonym: "interaction between organisms" EXACT [] synonym: "physiological interaction between organisms" EXACT [] synonym: "physiological interaction with other organism" EXACT [] is_a: GO:0008150 ! biological_process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051716 name: cellular response to stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell." [GOC:bf, GOC:jl] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: gosubset_prok is_a: GO:0009987 ! cellular process is_a: GO:0050896 ! response to stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051726 name: regulation of cell cycle namespace: biological_process alt_id: GO:0000074 def: "Any process that modulates the rate or extent of progression through the cell cycle." [GOC:ai, GOC:dph, GOC:tb] subset: goslim_yeast subset: gosubset_prok synonym: "cell cycle modulation" EXACT [] synonym: "cell cycle regulation" EXACT [] synonym: "cell cycle regulator" RELATED [] synonym: "control of cell cycle progression" EXACT [] synonym: "modulation of cell cycle progression" EXACT [] synonym: "regulation of cell cycle progression" EXACT [] synonym: "regulation of progression through cell cycle" EXACT [] synonym: "tumor suppressor" RELATED [] xref: Reactome:REACT_100159 "Inactivation of Myt1 kinase, Mus musculus" xref: Reactome:REACT_1006 "Polo-like kinase mediated events, Homo sapiens" xref: Reactome:REACT_102418 "Polo-like kinase mediated events, Schizosaccharomyces pombe" xref: Reactome:REACT_102475 "Inactivation of Myt1 kinase, Rattus norvegicus" xref: Reactome:REACT_103468 "Activation of Cdc25C, Drosophila melanogaster" xref: Reactome:REACT_104523 "Inactivation of Wee1 kinase, Bos taurus" xref: Reactome:REACT_105454 "Polo-like kinase mediated events, Dictyostelium discoideum" xref: Reactome:REACT_106237 "Polo-like kinase mediated events, Caenorhabditis elegans" xref: Reactome:REACT_106324 "Activation of Cdc25C, Mus musculus" xref: Reactome:REACT_107424 "Inactivation of Myt1 kinase, Canis familiaris" xref: Reactome:REACT_108578 "Inactivation of Myt1 kinase, Xenopus tropicalis" xref: Reactome:REACT_109244 "Inactivation of Myt1 kinase, Schizosaccharomyces pombe" xref: Reactome:REACT_109507 "Polo-like kinase mediated events, Taeniopygia guttata" xref: Reactome:REACT_109584 "Polo-like kinase mediated events, Saccharomyces cerevisiae" xref: Reactome:REACT_110774 "Inactivation of Myt1 kinase, Drosophila melanogaster" xref: Reactome:REACT_112480 "Inactivation of Wee1 kinase, Dictyostelium discoideum" xref: Reactome:REACT_113569 "Activation of Cdc25C, Saccharomyces cerevisiae" xref: Reactome:REACT_113990 "Activation of Cdc25C, Schizosaccharomyces pombe" xref: Reactome:REACT_114323 "Activation of Cdc25C, Caenorhabditis elegans" xref: Reactome:REACT_1944 "Inactivation of Wee1 kinase, Homo sapiens" xref: Reactome:REACT_2119 "Activation of Cdc25C, Homo sapiens" xref: Reactome:REACT_28091 "Inactivation of Wee1 kinase, Canis familiaris" xref: Reactome:REACT_29213 "Activation of Cdc25C, Rattus norvegicus" xref: Reactome:REACT_30490 "Inactivation of Myt1 kinase, Danio rerio" xref: Reactome:REACT_30836 "Inactivation of Myt1 kinase, Bos taurus" xref: Reactome:REACT_30859 "Polo-like kinase mediated events, Gallus gallus" xref: Reactome:REACT_32077 "Inactivation of Myt1 kinase, Dictyostelium discoideum" xref: Reactome:REACT_34285 "Activation of Cdc25C, Bos taurus" xref: Reactome:REACT_414 "Inactivation of Myt1 kinase, Homo sapiens" xref: Reactome:REACT_80617 "Inactivation of Wee1 kinase, Xenopus tropicalis" xref: Reactome:REACT_81789 "Polo-like kinase mediated events, Drosophila melanogaster" xref: Reactome:REACT_82824 "Inactivation of Wee1 kinase, Rattus norvegicus" xref: Reactome:REACT_83089 "Inactivation of Myt1 kinase, Saccharomyces cerevisiae" xref: Reactome:REACT_83883 "Polo-like kinase mediated events, Canis familiaris" xref: Reactome:REACT_87352 "Polo-like kinase mediated events, Danio rerio" xref: Reactome:REACT_88486 "Inactivation of Wee1 kinase, Taeniopygia guttata" xref: Reactome:REACT_89122 "Activation of Cdc25C, Canis familiaris" xref: Reactome:REACT_91085 "Inactivation of Wee1 kinase, Danio rerio" xref: Reactome:REACT_92033 "Inactivation of Myt1 kinase, Caenorhabditis elegans" xref: Reactome:REACT_93521 "Polo-like kinase mediated events, Mus musculus" xref: Reactome:REACT_93702 "Polo-like kinase mediated events, Rattus norvegicus" xref: Reactome:REACT_95088 "Inactivation of Wee1 kinase, Mus musculus" xref: Reactome:REACT_96524 "Activation of Cdc25C, Xenopus tropicalis" xref: Reactome:REACT_97306 "Polo-like kinase mediated events, Bos taurus" xref: Reactome:REACT_97384 "Polo-like kinase mediated events, Xenopus tropicalis" xref: Reactome:REACT_98443 "Inactivation of Wee1 kinase, Gallus gallus" xref: Reactome:REACT_99158 "Inactivation of Wee1 kinase, Drosophila melanogaster" is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007049 ! cell cycle relationship: regulates GO:0007049 ! cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051754 name: meiotic sister chromatid cohesion, centromeric namespace: biological_process def: "The cell cycle process in which centromeres of sister chromatids are joined during meiosis." [PMID:14730319, PMID:16325576] synonym: "centromeric meiotic sister chromatin cohesion" EXACT [GOC:bf] synonym: "meiotic sister chromatid cohesion at centromere" EXACT [] synonym: "sister chromatid cohesion at centromere at meiosis I" EXACT [] is_a: GO:0051177 ! meiotic sister chromatid cohesion is_a: GO:0070601 ! centromeric sister chromatid cohesion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051757 name: meiotic sister chromatid separation namespace: biological_process def: "The process in which sister chromatids are physically detached from each other during meiosis." [GOC:ai, PMID:14730319, PMID:16325576] synonym: "meiotic sister chromatid resolution" EXACT [GOC:mah] is_a: GO:0051307 ! meiotic chromosome separation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051760 name: meiotic sister chromatid cohesion, arms namespace: biological_process def: "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the length of the chromosome arms during meiosis." [PMID:14730319, PMID:16325576] synonym: "meiotic sister chromatid cohesion along arms" EXACT [] synonym: "sister chromatid cohesion along arms at meiosis I" EXACT [] is_a: GO:0051177 ! meiotic sister chromatid cohesion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051781 name: positive regulation of cell division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell division." [GOC:ai] synonym: "activation of cell division" NARROW [] synonym: "stimulation of cell division" NARROW [] synonym: "up regulation of cell division" EXACT [] synonym: "up-regulation of cell division" EXACT [] synonym: "upregulation of cell division" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0051301 ! cell division relationship: positively_regulates GO:0051301 ! cell division property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051782 name: negative regulation of cell division namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell division." [GOC:ai] synonym: "down regulation of cell division" EXACT [] synonym: "down-regulation of cell division" EXACT [] synonym: "downregulation of cell division" EXACT [] synonym: "inhibition of cell division" NARROW [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0051301 ! cell division relationship: negatively_regulates GO:0051301 ! cell division property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051783 name: regulation of nuclear division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0000280 ! nuclear division relationship: regulates GO:0000280 ! nuclear division property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051784 name: negative regulation of nuclear division namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] synonym: "down regulation of nuclear division" EXACT [] synonym: "down-regulation of nuclear division" EXACT [] synonym: "downregulation of nuclear division" EXACT [] synonym: "inhibition of nuclear division" NARROW [] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0051782 ! negative regulation of cell division is_a: GO:0051783 ! regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0000280 ! nuclear division relationship: negatively_regulates GO:0000280 ! nuclear division property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051785 name: positive regulation of nuclear division namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nuclear division, the partitioning of the nucleus and its genetic information." [GOC:ai] synonym: "activation of nuclear division" NARROW [] synonym: "stimulation of nuclear division" NARROW [] synonym: "up regulation of nuclear division" EXACT [] synonym: "up-regulation of nuclear division" EXACT [] synonym: "upregulation of nuclear division" EXACT [] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0051781 ! positive regulation of cell division is_a: GO:0051783 ! regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0000280 ! nuclear division relationship: positively_regulates GO:0000280 ! nuclear division property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051920 name: peroxiredoxin activity namespace: molecular_function def: "Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH." [EC:1.11.1.15] comment: Includes redox chemistry as part of the catalytic reaction (2 R'-SH = R'-S-S-R'), where R' refers to peroxiredoxin itself). Not to be confused with GO:0004601 (peroxidase activity, EC:1.11.1.7), which has a different reaction mechanism. subset: gosubset_prok synonym: "AhpC activity" NARROW [] synonym: "alkyl hydroperoxide reductase C22 activity" NARROW [] synonym: "PRDX activity" EXACT [] synonym: "Prx activity" EXACT [] synonym: "thiol-containing-reductant:hydroperoxide oxidoreductase activity" EXACT [EC:1.11.1.15] xref: EC:1.11.1.15 xref: MetaCyc:1.11.1.15-RXN is_a: GO:0016209 ! antioxidant activity is_a: GO:0016684 ! oxidoreductase activity, acting on peroxide as acceptor property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051938 name: L-glutamate import namespace: biological_process def: "The directed movement of L-glutamate, the L-enantiomer of the anion of 2-aminopentanedioic acid, into a cell or organelle." [GOC:ai, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "L-glutamate uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0015813 ! L-glutamate transport is_a: GO:0043092 ! L-amino acid import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051983 name: regulation of chromosome segregation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007059 ! chromosome segregation relationship: regulates GO:0007059 ! chromosome segregation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051984 name: positive regulation of chromosome segregation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] synonym: "activation of chromosome segregation" NARROW [] synonym: "stimulation of chromosome segregation" NARROW [] synonym: "up regulation of chromosome segregation" EXACT [] synonym: "up-regulation of chromosome segregation" EXACT [] synonym: "upregulation of chromosome segregation" EXACT [] is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051983 ! regulation of chromosome segregation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007059 ! chromosome segregation relationship: positively_regulates GO:0007059 ! chromosome segregation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0051985 name: negative regulation of chromosome segregation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chromosome segregation, the process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets." [GOC:ai] synonym: "down regulation of chromosome segregation" EXACT [] synonym: "down-regulation of chromosome segregation" EXACT [] synonym: "downregulation of chromosome segregation" EXACT [] synonym: "inhibition of chromosome segregation" NARROW [] is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051983 ! regulation of chromosome segregation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007059 ! chromosome segregation relationship: negatively_regulates GO:0007059 ! chromosome segregation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0052652 name: cyclic purine nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue and the base is a purine." [CHEBI:36982] synonym: "cyclic purine nucleotide metabolism" EXACT [] is_a: GO:0006164 ! purine nucleotide biosynthetic process is_a: GO:0009190 ! cyclic nucleotide biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl creation_date: 2010-09-23T11:15:59Z [Term] id: GO:0052820 name: DNA-1,N6-ethenoadenine N-glycosylase activity namespace: molecular_function def: "Catalysis of the reaction: DNA with 1-N6-ethenoadenine + H2O = DNA with abasic site + 1-N6-ethenoadenine. This reaction is the removal of 1,N6-ethenoadenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar." [PMID:21960007] synonym: "1,N(6)-ethenoadenine N-glycosylase activity" EXACT [] synonym: "1,N6-ethenoadenine glycosylase activity" EXACT [] is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl creation_date: 2011-10-28T01:17:21Z [Term] id: GO:0052905 name: tRNA (guanine(9)-N(1))-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanine(9) in tRNA = N(1)-methylguanine(9) in tRNA + S-adenosyl-L-homocysteine." [EC:2.1.1.221] synonym: "tRNA (guanine-N(1)-)-methyltransferase activity" EXACT [EC:2.1.1.221] synonym: "tRNA m(1)G(9) Mtase activity" EXACT [EC:2.1.1.221] synonym: "tRNA m(1)G(9)-methyltransferase activity" EXACT [EC:2.1.1.221] synonym: "tRNA(m(1)G(9)/m(1)A(9))-methyltransferase activity" EXACT [EC:2.1.1.221] synonym: "tRNA(m(1)G(9)/m(1)A(9))Mtase activity" EXACT [EC:2.1.1.221] xref: EC:2.1.1.221 xref: MetaCyc:RXN-12459 is_a: GO:0009019 ! tRNA (guanine-N1-)-methyltransferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0055082 name: cellular chemical homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state of a chemical at the level of the cell." [GOC:isa_complete, GOC:jid] subset: gosubset_prok is_a: GO:0019725 ! cellular homeostasis is_a: GO:0048878 ! chemical homeostasis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0055085 name: transmembrane transport namespace: biological_process def: "The process in which a solute is transported from one side of a membrane to the other." [GOC:dph, GOC:jid] comment: Transmembrane transport requires transport of a solute across a lipid bilayer. Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane and is not traversed. For transport through the nuclear pore, consider instead the term 'nucleocytoplasmic transport ; GO:0006913' and its children. Note also that this term is not intended for use in annotating lateral movement within membranes. subset: goslim_chembl subset: goslim_generic subset: goslim_pombe subset: goslim_yeast synonym: "membrane transport" EXACT [] xref: Reactome:REACT_100480 "SLC-mediated transmembrane transport, Taeniopygia guttata" xref: Reactome:REACT_101577 "SLC-mediated transmembrane transport, Caenorhabditis elegans" xref: Reactome:REACT_101877 "SLC-mediated transmembrane transport, Escherichia coli" xref: Reactome:REACT_101975 "SLC-mediated transmembrane transport, Sus scrofa" xref: Reactome:REACT_102348 "Transmembrane transport of small molecules, Staphylococcus aureus N315" xref: Reactome:REACT_102897 "Transmembrane transport of small molecules, Caenorhabditis elegans" xref: Reactome:REACT_102974 "SLC-mediated transmembrane transport, Canis familiaris" xref: Reactome:REACT_104555 "SLC-mediated transmembrane transport, Xenopus tropicalis" xref: Reactome:REACT_108243 "SLC-mediated transmembrane transport, Staphylococcus aureus N315" xref: Reactome:REACT_109832 "Transmembrane transport of small molecules, Plasmodium falciparum" xref: Reactome:REACT_110770 "ABC-family proteins mediated transport, Mus musculus" xref: Reactome:REACT_114546 "ABC-family proteins mediated transport, Staphylococcus aureus N315" xref: Reactome:REACT_114763 "ABC-family proteins mediated transport, Escherichia coli" xref: Reactome:REACT_114890 "ABC-family proteins mediated transport, Plasmodium falciparum" xref: Reactome:REACT_115378 "ABC-family proteins mediated transport, Mycobacterium tuberculosis" xref: Reactome:REACT_15480 "ABC-family proteins mediated transport, Homo sapiens" xref: Reactome:REACT_15518 "Transmembrane transport of small molecules, Homo sapiens" xref: Reactome:REACT_19118 "SLC-mediated transmembrane transport, Homo sapiens" xref: Reactome:REACT_29093 "ABC-family proteins mediated transport, Taeniopygia guttata" xref: Reactome:REACT_29184 "SLC-mediated transmembrane transport, Gallus gallus" xref: Reactome:REACT_29635 "Transmembrane transport of small molecules, Canis familiaris" xref: Reactome:REACT_30969 "ABC-family proteins mediated transport, Canis familiaris" xref: Reactome:REACT_32055 "Transmembrane transport of small molecules, Saccharomyces cerevisiae" xref: Reactome:REACT_32223 "Transmembrane transport of small molecules, Rattus norvegicus" xref: Reactome:REACT_32423 "SLC-mediated transmembrane transport, Bos taurus" xref: Reactome:REACT_32713 "ABC-family proteins mediated transport, Sus scrofa" xref: Reactome:REACT_33571 "SLC-mediated transmembrane transport, Danio rerio" xref: Reactome:REACT_61245 "Transmembrane transport of small molecules, Bos taurus" xref: Reactome:REACT_79086 "SLC-mediated transmembrane transport, Plasmodium falciparum" xref: Reactome:REACT_79921 "SLC-mediated transmembrane transport, Saccharomyces cerevisiae" xref: Reactome:REACT_80022 "ABC-family proteins mediated transport, Bos taurus" xref: Reactome:REACT_80510 "ABC-family proteins mediated transport, Rattus norvegicus" xref: Reactome:REACT_80848 "ABC-family proteins mediated transport, Schizosaccharomyces pombe" xref: Reactome:REACT_80977 "ABC-family proteins mediated transport, Caenorhabditis elegans" xref: Reactome:REACT_81024 "Transmembrane transport of small molecules, Oryza sativa" xref: Reactome:REACT_81153 "SLC-mediated transmembrane transport, Mus musculus" xref: Reactome:REACT_82725 "SLC-mediated transmembrane transport, Rattus norvegicus" xref: Reactome:REACT_83770 "Transmembrane transport of small molecules, Escherichia coli" xref: Reactome:REACT_86135 "ABC-family proteins mediated transport, Oryza sativa" xref: Reactome:REACT_86409 "Transmembrane transport of small molecules, Drosophila melanogaster" xref: Reactome:REACT_86576 "Transmembrane transport of small molecules, Schizosaccharomyces pombe" xref: Reactome:REACT_87124 "SLC-mediated transmembrane transport, Oryza sativa" xref: Reactome:REACT_88059 "ABC-family proteins mediated transport, Xenopus tropicalis" xref: Reactome:REACT_88521 "Transmembrane transport of small molecules, Taeniopygia guttata" xref: Reactome:REACT_88894 "Transmembrane transport of small molecules, Gallus gallus" xref: Reactome:REACT_89376 "SLC-mediated transmembrane transport, Schizosaccharomyces pombe" xref: Reactome:REACT_91272 "ABC-family proteins mediated transport, Arabidopsis thaliana" xref: Reactome:REACT_91803 "SLC-mediated transmembrane transport, Mycobacterium tuberculosis" xref: Reactome:REACT_92006 "Transmembrane transport of small molecules, Mycobacterium tuberculosis" xref: Reactome:REACT_92624 "ABC-family proteins mediated transport, Gallus gallus" xref: Reactome:REACT_93747 "Transmembrane transport of small molecules, Dictyostelium discoideum" xref: Reactome:REACT_94160 "Transmembrane transport of small molecules, Mus musculus" xref: Reactome:REACT_94393 "ABC-family proteins mediated transport, Drosophila melanogaster" xref: Reactome:REACT_94944 "ABC-family proteins mediated transport, Danio rerio" xref: Reactome:REACT_94972 "SLC-mediated transmembrane transport, Dictyostelium discoideum" xref: Reactome:REACT_96633 "Transmembrane transport of small molecules, Sus scrofa" xref: Reactome:REACT_96636 "SLC-mediated transmembrane transport, Arabidopsis thaliana" xref: Reactome:REACT_97365 "Transmembrane transport of small molecules, Arabidopsis thaliana" xref: Reactome:REACT_97867 "ABC-family proteins mediated transport, Saccharomyces cerevisiae" xref: Reactome:REACT_98509 "Transmembrane transport of small molecules, Xenopus tropicalis" xref: Reactome:REACT_98716 "SLC-mediated transmembrane transport, Drosophila melanogaster" xref: Reactome:REACT_99579 "Transmembrane transport of small molecules, Danio rerio" xref: Reactome:REACT_99829 "ABC-family proteins mediated transport, Dictyostelium discoideum" is_a: GO:0044763 ! single-organism cellular process is_a: GO:0044765 ! single-organism transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0055086 name: nucleobase-containing small molecule metabolic process namespace: biological_process def: "The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide." [GOC:vw] subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "nucleobase, nucleoside and nucleotide metabolic process" RELATED [] synonym: "nucleobase, nucleoside and nucleotide metabolism" EXACT [] xref: Reactome:REACT_100770 "Metabolism of nucleotides, Plasmodium falciparum" xref: Reactome:REACT_105851 "Metabolism of nucleotides, Schizosaccharomyces pombe" xref: Reactome:REACT_107755 "Metabolism of nucleotides, Mycobacterium tuberculosis" xref: Reactome:REACT_107894 "Metabolism of nucleotides, Rattus norvegicus" xref: Reactome:REACT_116039 "Nucleotide metabolism, Gallus gallus" xref: Reactome:REACT_1698 "Metabolism of nucleotides, Homo sapiens" xref: Reactome:REACT_28046 "Metabolism of nucleotides, Drosophila melanogaster" xref: Reactome:REACT_29205 "Metabolism of nucleotides, Dictyostelium discoideum" xref: Reactome:REACT_29767 "Metabolism of nucleotides, Saccharomyces cerevisiae" xref: Reactome:REACT_31512 "Metabolism of nucleotides, Sus scrofa" xref: Reactome:REACT_33967 "Metabolism of nucleotides, Mus musculus" xref: Reactome:REACT_77113 "Metabolism of nucleotides, Taeniopygia guttata" xref: Reactome:REACT_78257 "Metabolism of nucleotides, Staphylococcus aureus N315" xref: Reactome:REACT_82673 "Metabolism of nucleotides, Caenorhabditis elegans" xref: Reactome:REACT_82902 "Metabolism of nucleotides, Canis familiaris" xref: Reactome:REACT_82978 "Metabolism of nucleotides, Escherichia coli" xref: Reactome:REACT_83845 "Metabolism of nucleotides, Bos taurus" xref: Reactome:REACT_86759 "Metabolism of nucleotides, Oryza sativa" xref: Reactome:REACT_90903 "Metabolism of nucleotides, Gallus gallus" xref: Reactome:REACT_96600 "Metabolism of nucleotides, Danio rerio" xref: Reactome:REACT_97332 "Metabolism of nucleotides, Arabidopsis thaliana" xref: Reactome:REACT_99343 "Metabolism of nucleotides, Xenopus tropicalis" is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0044763 ! single-organism cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0055114 name: oxidation-reduction process namespace: biological_process def: "A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons." [GOC:dhl, GOC:ecd, GOC:jh2, GOC:jid, GOC:mlg, GOC:rph] subset: goslim_metagenomics subset: gosubset_prok synonym: "oxidation reduction" EXACT [GOC:curators] synonym: "oxidoreductase process" EXACT systematic_synonym [] xref: Wikipedia:Redox is_a: GO:0044710 ! single-organism metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0060151 name: peroxisome localization namespace: biological_process def: "Any process in which a peroxisome is transported to, and/or maintained in, a specific location. A peroxisome is a small membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:dph, PMID:16449325] synonym: "peroxisome localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0060187 name: cell pole namespace: cellular_component def: "Either of two different areas at opposite ends of an axis of a cell." [GOC:dph] comment: Note that this term differs from 'cell tip ; GO:0051286' in that it is applicable to a broader range of cell shapes. is_a: GO:0044464 ! cell part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0060249 name: anatomical structure homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of an internal steady state within a defined anatomical structure of an organism, including control of cellular proliferation and death and control of metabolic function. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph] synonym: "anatomical structure maintenance" EXACT [GOC:dph] is_a: GO:0042592 ! homeostatic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0060255 name: regulation of macromolecule metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] subset: gosubset_prok is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0043170 ! macromolecule metabolic process relationship: regulates GO:0043170 ! macromolecule metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0060274 name: maintenance of stationary phase namespace: biological_process def: "The homeostatic process in which a population of cells changes its metabolic activity resulting in the rate of death in the population equaling the rate of reproduction. Stationary phase can be in response to limited nutrients or a build-up of toxic substances in the environment." [GOC:dph] is_a: GO:0048874 ! homeostasis of number of cells in a free-living population property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0060356 name: leucine import namespace: biological_process def: "The directed movement of leucine into a cell or organelle." [GOC:dph, GOC:tb] synonym: "L-leucine import" NARROW [] synonym: "L-leucine uptake" NARROW [] synonym: "leucine uptake" EXACT [] is_a: GO:0015820 ! leucine transport is_a: GO:0043090 ! amino acid import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0060560 name: developmental growth involved in morphogenesis namespace: biological_process def: "The increase in size or mass of an anatomical structure that contributes to the structure attaining its shape." [GOC:dph] synonym: "differential growth" EXACT [GOC:dph] is_a: GO:0048589 ! developmental growth intersection_of: GO:0048589 ! developmental growth intersection_of: part_of GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0009653 ! anatomical structure morphogenesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: dph creation_date: 2009-04-28T08:42:53Z [Term] id: GO:0061024 name: membrane organization namespace: biological_process alt_id: GO:0016044 def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:dph, GOC:tb] subset: goslim_chembl subset: goslim_generic subset: goslim_pombe synonym: "cellular membrane organisation" EXACT [GOC:curators] synonym: "cellular membrane organization" EXACT [] synonym: "membrane organisation" EXACT [GOC:mah] synonym: "membrane organization and biogenesis" RELATED [GOC:mah] xref: Reactome:REACT_101524 "Membrane Trafficking, Dictyostelium discoideum" xref: Reactome:REACT_103082 "Membrane Trafficking, Schizosaccharomyces pombe" xref: Reactome:REACT_11123 "Membrane Trafficking, Homo sapiens" xref: Reactome:REACT_29278 "Membrane Trafficking, Sus scrofa" xref: Reactome:REACT_32337 "Membrane Trafficking, Taeniopygia guttata" xref: Reactome:REACT_33741 "Membrane Trafficking, Bos taurus" xref: Reactome:REACT_34084 "Membrane Trafficking, Caenorhabditis elegans" xref: Reactome:REACT_78213 "Membrane Trafficking, Plasmodium falciparum" xref: Reactome:REACT_78288 "Membrane Trafficking, Xenopus tropicalis" xref: Reactome:REACT_83546 "Membrane Trafficking, Oryza sativa" xref: Reactome:REACT_86557 "Membrane Trafficking, Arabidopsis thaliana" xref: Reactome:REACT_87431 "Membrane Trafficking, Drosophila melanogaster" xref: Reactome:REACT_88307 "Membrane Trafficking, Mus musculus" xref: Reactome:REACT_91154 "Membrane Trafficking, Saccharomyces cerevisiae" xref: Reactome:REACT_93714 "Membrane Trafficking, Danio rerio" xref: Reactome:REACT_95586 "Membrane Trafficking, Gallus gallus" xref: Reactome:REACT_96516 "Membrane Trafficking, Canis familiaris" xref: Reactome:REACT_97881 "Membrane Trafficking, Rattus norvegicus" is_a: GO:0016043 ! cellular component organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: dph creation_date: 2010-02-08T02:43:11Z [Term] id: GO:0061025 name: membrane fusion namespace: biological_process alt_id: GO:0006944 def: "The membrane organization process that joins two lipid bilayers to form a single membrane." [GOC:dph, GOC:tb] subset: goslim_yeast synonym: "cellular membrane fusion" EXACT [] xref: Wikipedia:Lipid_bilayer_fusion is_a: GO:0061024 ! membrane organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: dph creation_date: 2010-02-08T02:48:06Z [Term] id: GO:0061136 name: regulation of proteasomal protein catabolic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:dph, GOC:tb] is_a: GO:1903050 ! regulation of proteolysis involved in cellular protein catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0010498 ! proteasomal protein catabolic process relationship: regulates GO:0010498 ! proteasomal protein catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: dph creation_date: 2010-05-17T01:33:20Z [Term] id: GO:0061458 name: reproductive system development namespace: biological_process def: "The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction." [GOC:dph] is_a: GO:0048731 ! system development property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: dph creation_date: 2012-08-22T17:47:53Z [Term] id: GO:0061460 name: L-histidine import namespace: biological_process def: "The directed movement of L-histidine into a cell or organelle." [GOC:dph] is_a: GO:0043092 ! L-amino acid import is_a: GO:0090466 ! histidine import is_a: GO:1902024 ! L-histidine transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: dph creation_date: 2012-10-05T10:20:50Z [Term] id: GO:0061461 name: L-lysine import namespace: biological_process def: "The directed movement of L-lysine into a cell or organelle." [GOC:dph] is_a: GO:0034226 ! lysine import is_a: GO:0043092 ! L-amino acid import is_a: GO:1902022 ! L-lysine transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: dph creation_date: 2012-10-05T10:22:26Z [Term] id: GO:0061488 name: adenine import into cell namespace: biological_process def: "The directed movement of adenine from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dph, GOC:mah] is_a: GO:0015853 ! adenine transport is_a: GO:0098657 ! import into cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: dph creation_date: 2012-12-06T14:51:42Z [Term] id: GO:0061489 name: guanine import into cell namespace: biological_process def: "The directed movement of guanine from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dph, GOC:mah] is_a: GO:0015854 ! guanine transport is_a: GO:0098657 ! import into cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: dph creation_date: 2012-12-06T14:52:43Z [Term] id: GO:0061490 name: glucose import into cell namespace: biological_process def: "The directed movement of glucose from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dph, GOC:mah] is_a: GO:0046323 ! glucose import is_a: GO:0097319 ! carbohydrate import into cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: dph creation_date: 2012-12-06T14:54:07Z [Term] id: GO:0061492 name: asymmetric protein localization to old or new spindle pole body namespace: biological_process def: "Any process in which a protein is transported to, or maintained to either the old or new spindle pole body resulting in its being distributed asymmetrically." [GOC:dph, PMID:22119525] is_a: GO:0008105 ! asymmetric protein localization is_a: GO:0071988 ! protein localization to spindle pole body property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: dph creation_date: 2012-12-06T15:23:15Z [Term] id: GO:0061505 name: DNA topoisomerase II activity namespace: molecular_function def: "Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; changes the linking number in multiples of 2." [GOC:dph] is_a: GO:0003916 ! DNA topoisomerase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: dph creation_date: 2013-01-23T10:40:04Z [Term] id: GO:0061510 name: asymmetric protein localization to new mitotic spindle pole body namespace: biological_process def: "Any process in which a protein is transported to, or maintained to the new mitotic spindle pole body resulting in its being distributed asymmetrically." [GOC:dph, GOC:vw] is_a: GO:0061492 ! asymmetric protein localization to old or new spindle pole body is_a: GO:1902440 ! protein localization to mitotic spindle pole body property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: dph creation_date: 2013-02-21T13:49:54Z [Term] id: GO:0061572 name: actin filament bundle organization namespace: biological_process def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle." [GOC:dph] synonym: "actin filament cable organization" RELATED [GOC:dph] is_a: GO:0007015 ! actin filament organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: dph creation_date: 2013-08-02T11:24:11Z [Term] id: GO:0061573 name: actin filament bundle retrograde transport namespace: biological_process def: "A process of actin filament bundle distribution that results in the arrangement of actin filament bundles from the periphery toward the interior of the cell." [GOC:dph] synonym: "actin filament cable retrograde transport" RELATED [GOC:dph] is_a: GO:0070650 ! actin filament bundle distribution property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: dph creation_date: 2013-08-02T11:31:04Z [Term] id: GO:0061630 name: ubiquitin protein ligase activity namespace: molecular_function def: "Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S --> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate. Note that this may include the extension of ubiquitin chains." [GOC:BioGRID, GOC:dph] synonym: "E3" RELATED [GOC:dph] synonym: "protein ubiquitination activity" EXACT [GOC:dph] synonym: "ubiquitin ligase activity" EXACT [GOC:dph] is_a: GO:0004842 ! ubiquitin-protein transferase activity is_a: GO:0061659 ! ubiquitin-like protein ligase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: dph creation_date: 2014-05-18T09:11:21Z [Term] id: GO:0061640 name: cytoskeleton-dependent cytokinesis namespace: biological_process def: "A cytokinesis that involves the function of a set of proteins that are part of the microfilament or microtubule cytoskeleton." [GOC:dph] is_a: GO:0000910 ! cytokinesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: dph creation_date: 2014-08-22T14:21:35Z [Term] id: GO:0061641 name: CENP-A containing chromatin organization namespace: biological_process def: "Any process that results in the specification, formation or maintenance of the physical structure of CENP-A containing chromatin." [GOC:dph] synonym: "centromeric chromatin organization" RELATED [GOC:dph] is_a: GO:0006325 ! chromatin organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: dph creation_date: 2014-08-27T12:26:14Z [Term] id: GO:0061644 name: protein localization to CENP-A containing chromatin namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, CENP-A containing chromatin." [GOC:dph, GOC:vw] is_a: GO:0071168 ! protein localization to chromatin is_a: GO:0071459 ! protein localization to chromosome, centromeric region property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: dph creation_date: 2014-08-29T12:17:05Z [Term] id: GO:0061645 name: endocytic patch namespace: cellular_component def: "The part of the cell cortex consisting of an aggregation of proteins that will give rise to an endocytic vesicle." [GOC:dph, PMID:22949647] is_a: GO:0044448 ! cell cortex part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: dph creation_date: 2014-09-02T09:23:38Z [Term] id: GO:0061647 name: histone H3-K9 modification namespace: biological_process def: "The modification of histone H3 at a lysine in position 9 of the histone." [GOC:vw] is_a: GO:0016570 ! histone modification property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: dph creation_date: 2014-10-02T15:07:42Z [Term] id: GO:0061659 name: ubiquitin-like protein ligase activity namespace: molecular_function def: "Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S --> X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate." [GOC:dph] synonym: "E3" RELATED [GOC:dph] synonym: "small conjugating protein ligase activity" EXACT [GOC:dph] is_a: GO:0019787 ! ubiquitin-like protein transferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: dph creation_date: 2014-11-06T13:46:23Z [Term] id: GO:0061726 name: mitochondrion disassembly namespace: biological_process def: "The disaggregation of a mitochondrion into its constituent components." [GOC:autophagy, PMID:25009776] synonym: "mitochondrion degradation" EXACT [GOC:autophagy] is_a: GO:1903008 ! organelle disassembly property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: dph creation_date: 2015-07-08T13:59:16Z [Term] id: GO:0061727 name: methylglyoxal catabolic process to lactate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into lactate." [GOC:dph, PMID:2198020] is_a: GO:0006089 ! lactate metabolic process is_a: GO:0051596 ! methylglyoxal catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: dph creation_date: 2015-07-21T17:25:57Z [Term] id: GO:0065003 name: macromolecular complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of macromolecules to form a complex." [GOC:jl] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: gosubset_prok synonym: "macromolecule complex assembly" EXACT [] is_a: GO:0022607 ! cellular component assembly is_a: GO:0043933 ! macromolecular complex subunit organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0065004 name: protein-DNA complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex." [GOC:jl] subset: gosubset_prok synonym: "DNA-protein complex assembly" EXACT [GOC:mah] is_a: GO:0034622 ! cellular macromolecular complex assembly is_a: GO:0071824 ! protein-DNA complex subunit organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0065007 name: biological regulation namespace: biological_process def: "Any process that modulates a measurable attribute of any biological process, quality or function." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] subset: goslim_pir subset: gosubset_prok synonym: "regulation" BROAD [] is_a: GO:0008150 ! biological_process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0065008 name: regulation of biological quality namespace: biological_process def: "Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:dph, GOC:isa_complete, GOC:mah, GOC:pr, GOC:vw] subset: gosubset_prok synonym: "regulation of biological attribute" EXACT [] synonym: "regulation of biological characteristic" EXACT [] is_a: GO:0065007 ! biological regulation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0065009 name: regulation of molecular function namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GOC:isa_complete] subset: gosubset_prok synonym: "regulation of a molecular function" EXACT [] is_a: GO:0065007 ! biological regulation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0003674 ! molecular_function relationship: regulates GO:0003674 ! molecular_function property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0070011 name: peptidase activity, acting on L-amino acid peptides namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds formed between L-amino acids." [GOC:mah] subset: gosubset_prok is_a: GO:0008233 ! peptidase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0070013 name: intracellular organelle lumen namespace: cellular_component def: "An organelle lumen that is part of an intracellular organelle." [GOC:mah] is_a: GO:0043233 ! organelle lumen is_a: GO:0044446 ! intracellular organelle part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0070035 name: purine NTP-dependent helicase activity namespace: molecular_function def: "Catalysis of the reaction: purine NTP + H2O = purine NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah] subset: gosubset_prok is_a: GO:0004386 ! helicase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0070061 name: fructose binding namespace: molecular_function def: "Interacting selectively and non-covalently with the D- or L-enantiomer of fructose, the ketohexose arabino-hex-2-ulose." [CHEBI:28757, GOC:BHF, GOC:mah] subset: gosubset_prok is_a: GO:0048029 ! monosaccharide binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0070069 name: cytochrome complex namespace: cellular_component def: "A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions." [GOC:mah] is_a: GO:0043234 ! protein complex property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0070085 name: glycosylation namespace: biological_process def: "The covalent attachment and further modification of carbohydrate residues to a substrate molecule." [GOC:hjd, GOC:mah] xref: Wikipedia:Glycosylation is_a: GO:0044723 ! single-organism carbohydrate metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0070192 name: chromosome organization involved in meiosis namespace: biological_process def: "A process of chromosome organization that is involved in meiosis." [GOC:mah] synonym: "chromosome organisation involved in meiosis" EXACT [GOC:mah] synonym: "meiotic chromosome organization" EXACT [GOC:mah] is_a: GO:0051276 ! chromosome organization is_a: GO:1902589 ! single-organism organelle organization is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0051276 ! chromosome organization intersection_of: part_of GO:0007126 ! meiotic nuclear division relationship: part_of GO:0007126 ! meiotic nuclear division property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0070198 name: protein localization to chromosome, telomeric region namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, the telomeric region of a chromosome." [GOC:BHF, GOC:mah] synonym: "protein localisation to chromosome, telomeric region" EXACT [GOC:mah] synonym: "protein localization to telomere" EXACT [GOC:mah] is_a: GO:0034502 ! protein localization to chromosome property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0070224 name: sulfide:quinone oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: hydrogen sulfide + a quinone = S0 + a hydroquinone." [MetaCyc:R17-RXN] subset: gosubset_prok synonym: "sulfide-quinone reductase activity" EXACT [MetaCyc:MONOMER-12314] synonym: "sulphide:quinone oxidoreductase activity" EXACT [GOC:mah] xref: EC:1.8.5.- xref: MetaCyc:R17-RXN xref: Reactome:REACT_115885 "SQR oxidizes sulfide to bound persulfide, Homo sapiens" is_a: GO:0016672 ! oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0070271 name: protein complex biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a protein complex. Includes the synthesis of non-protein components, and those protein modifications that are involved in synthesis or assembly of the complex." [GOC:mah] comment: This classification should should only be used for complexes where synthesis of some non-protein component is necessary for assembly. subset: goslim_yeast subset: gosubset_prok synonym: "protein complex biogenesis and assembly" EXACT [GOC:mah] is_a: GO:0044085 ! cellular component biogenesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0070301 name: cellular response to hydrogen peroxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [CHEBI:16240, GOC:mah] is_a: GO:0034614 ! cellular response to reactive oxygen species is_a: GO:0042542 ! response to hydrogen peroxide property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0070314 name: G1 to G0 transition namespace: biological_process def: "A cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters a specialized resting state known as G0 or quiescence." [GOC:mah, GOC:mtg_cell_cycle, ISBN:0815316194] synonym: "cell cycle quiescence" RELATED [GOC:mah] synonym: "establishment of cell quiescence" EXACT [GOC:mah] synonym: "G1/G0 transition" EXACT [GOC:mah] synonym: "stationary phase" RELATED [GOC:mah] is_a: GO:0022402 ! cell cycle process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0070316 name: regulation of G0 to G1 transition namespace: biological_process def: "A cell cycle process that modulates the rate or extent of the transition from the G0 quiescent state to the G1 phase." [GOC:mah] is_a: GO:0010564 ! regulation of cell cycle process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0045023 ! G0 to G1 transition relationship: regulates GO:0045023 ! G0 to G1 transition property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0070317 name: negative regulation of G0 to G1 transition namespace: biological_process def: "A cell cycle process that stops, prevents, or reduces the rate or extent of the transition from the G0 quiescent state to the G1 phase." [GOC:mah] synonym: "maintenance of cell cycle quiescence" EXACT [GOC:mah] synonym: "maintenance of cell quiescence" EXACT [GOC:mah] synonym: "maintenance of G0 arrest" EXACT [GOC:mah] synonym: "maintenance of G0 phase" EXACT [GOC:mah] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0070316 ! regulation of G0 to G1 transition intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0045023 ! G0 to G1 transition relationship: negatively_regulates GO:0045023 ! G0 to G1 transition property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0070321 name: regulation of translation in response to nitrogen starvation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the frequency, rate or extent of translation as a result of a stimulus indicating deprivation of nitrogen." [GOC:mah] is_a: GO:0006995 ! cellular response to nitrogen starvation is_a: GO:0043555 ! regulation of translation in response to stress property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0070382 name: exocytic vesicle namespace: cellular_component def: "A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis." [GOC:kad, GOC:mah] synonym: "exocytic constitutive secretory pathway transport vesicle" EXACT [] synonym: "exocytotic vesicle" EXACT [GOC:kad] is_a: GO:0030133 ! transport vesicle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0070417 name: cellular response to cold namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:jp] synonym: "cellular response to cold stress" EXACT [GOC:jp] is_a: GO:0009409 ! response to cold is_a: GO:0033554 ! cellular response to stress property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0070469 name: respiratory chain namespace: cellular_component def: "The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:ecd, GOC:mah, ISBN:0198547684] subset: goslim_metagenomics synonym: "membrane electron transport chain" EXACT [GOC:mah] is_a: GO:0044425 ! membrane part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0070482 name: response to oxygen levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:BHF, GOC:mah] is_a: GO:0009628 ! response to abiotic stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0070509 name: calcium ion import namespace: biological_process def: "The directed movement of calcium ions into a cell or organelle." [GOC:mah] synonym: "calcium ion uptake" EXACT [GOC:mah] synonym: "transmembrane calcium influx" RELATED [GOC:tb] is_a: GO:0030001 ! metal ion transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0070569 name: uridylyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an uridylyl group to an acceptor." [GOC:mah] subset: gosubset_prok is_a: GO:0016779 ! nucleotidyltransferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-04-15T11:06:07Z [Term] id: GO:0070574 name: cadmium ion transmembrane transport namespace: biological_process def: "A process in which a cadmium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. subset: gosubset_prok synonym: "cadmium ion membrane transport" EXACT [] synonym: "transmembrane cadmium transport" EXACT [GOC:mah] is_a: GO:0015691 ! cadmium ion transport is_a: GO:0098662 ! inorganic cation transmembrane transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-04-20T03:31:47Z [Term] id: GO:0070585 name: protein localization to mitochondrion namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within the mitochondrion." [GOC:ecd] synonym: "protein localisation in mitochondrion" EXACT [GOC:mah] synonym: "protein localization in mitochondrion" EXACT [GOC:curators] is_a: GO:0033365 ! protein localization to organelle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-04-24T02:31:18Z [Term] id: GO:0070590 name: spore wall biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a spore wall. A spore wall is the specialized cell wall lying outside the cell membrane of a spore." [GOC:mah] is_a: GO:0042546 ! cell wall biogenesis relationship: part_of GO:0030435 ! sporulation resulting in formation of a cellular spore property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-04-28T01:06:10Z [Term] id: GO:0070591 name: ascospore wall biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of an ascospore wall." [GOC:mah] is_a: GO:0009272 ! fungal-type cell wall biogenesis is_a: GO:0070590 ! spore wall biogenesis is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0030437 ! ascospore formation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-04-28T01:12:11Z [Term] id: GO:0070601 name: centromeric sister chromatid cohesion namespace: biological_process def: "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the length of the centromeric region of the chromosome." [GOC:mah] synonym: "sister chromatid cohesion at centromere" EXACT [GOC:mah] is_a: GO:0007062 ! sister chromatid cohesion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-04-28T04:31:00Z [Term] id: GO:0070627 name: ferrous iron import namespace: biological_process def: "The directed movement of ferrous iron (Fe(II) or Fe2+) ions across a membrane into a cell or organelle." [GOC:mah] synonym: "ferrous ion import" EXACT [] synonym: "ferrous iron uptake" EXACT [] is_a: GO:0015684 ! ferrous iron transport is_a: GO:0097286 ! iron ion import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-05-01T04:19:14Z [Term] id: GO:0070631 name: spindle pole body localization namespace: biological_process def: "Any process in which a spindle pole body is transported to, or maintained in, a specific location. A spindle pole body is a type of microtubule organizing center found in fungal cells." [GOC:mah] synonym: "establishment and maintenance of spindle pole body localization" EXACT [GOC:mah] synonym: "spindle pole body localisation" EXACT [GOC:mah] is_a: GO:0051641 ! cellular localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-05-06T02:21:38Z [Term] id: GO:0070632 name: establishment of spindle pole body localization namespace: biological_process def: "Any process in which a spindle pole body is transported to a specific location. A spindle pole body is a type of microtubule organizing center found in fungal cells." [GOC:mah] synonym: "establishment of spindle pole body localisation" EXACT [GOC:mah] synonym: "spindle pole body positioning" EXACT [GOC:vw] is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0070631 ! spindle pole body localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-05-06T02:35:32Z [Term] id: GO:0070647 name: protein modification by small protein conjugation or removal namespace: biological_process def: "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein." [GOC:mah] subset: goslim_pombe subset: goslim_yeast is_a: GO:0006464 ! cellular protein modification process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-05-11T02:54:03Z [Term] id: GO:0070650 name: actin filament bundle distribution namespace: biological_process def: "Any cellular process that establishes the spatial arrangement of actin filament bundles within the cell." [GOC:mah] is_a: GO:0061572 ! actin filament bundle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-05-12T02:20:58Z [Term] id: GO:0070717 name: poly-purine tract binding namespace: molecular_function def: "Interacting selectively and non-covalently with any stretch of purines (adenine or guanine) in an RNA molecule." [GOC:mah] is_a: GO:0003727 ! single-stranded RNA binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-06-10T03:32:15Z [Term] id: GO:0070726 name: cell wall assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells." [GOC:mah] is_a: GO:0022607 ! cellular component assembly is_a: GO:0071555 ! cell wall organization relationship: part_of GO:0042546 ! cell wall biogenesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-06-16T03:58:20Z [Term] id: GO:0070727 name: cellular macromolecule localization namespace: biological_process def: "Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell." [GOC:mah] synonym: "cellular macromolecule localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization is_a: GO:0051641 ! cellular localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-06-16T04:08:29Z [Term] id: GO:0070783 name: growth of unicellular organism as a thread of attached cells namespace: biological_process def: "A filamentous growth process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium such as an agar plate, exhibited by unicellular fungi under certain growth conditions." [GOC:mah, GOC:mcc] subset: goslim_candida is_a: GO:0044182 ! filamentous growth of a population of unicellular organisms property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-07-07T02:21:14Z [Term] id: GO:0070813 name: hydrogen sulfide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hydrogen sulfide, H2S." [CHEBI:16136, GOC:mah] synonym: "hydrogen sulfide metabolism" EXACT [GOC:mah] synonym: "hydrogen sulphide metabolic process" EXACT [GOC:mah] synonym: "hydrogen sulphide metabolism" EXACT [GOC:mah] is_a: GO:0006790 ! sulfur compound metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-07-09T10:37:32Z [Term] id: GO:0070814 name: hydrogen sulfide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hydrogen sulfide, H2S." [CHEBI:16136, GOC:mah] synonym: "hydrogen sulfide anabolism" EXACT [GOC:mah] synonym: "hydrogen sulfide biosynthesis" EXACT [GOC:mah] synonym: "hydrogen sulfide formation" EXACT [GOC:mah] synonym: "hydrogen sulfide synthesis" EXACT [GOC:mah] synonym: "hydrogen sulphide biosynthesis" EXACT [GOC:mah] synonym: "hydrogen sulphide biosynthetic process" EXACT [GOC:mah] is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0070813 ! hydrogen sulfide metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-07-09T10:45:02Z [Term] id: GO:0070816 name: phosphorylation of RNA polymerase II C-terminal domain namespace: biological_process alt_id: GO:0016245 def: "The process of introducing a phosphate group on to an amino acid residue in the C-terminal domain of RNA polymerase II. Typically, this occurs during the transcription cycle and results in production of an RNA polymerase II enzyme where the carboxy-terminal domain (CTD) of the largest subunit is extensively phosphorylated, often referred to as hyperphosphorylated or the II(0) form. Specific types of phosphorylation within the CTD are usually associated with specific regions of genes, though there are exceptions. The phosphorylation state regulates the association of specific complexes such as the capping enzyme or 3'-RNA processing machinery to the elongating RNA polymerase complex." [GOC:krc, GOC:mah, PMID:17079683] synonym: "CTD domain phosphorylation of RNA polymerase II" EXACT [GOC:mah] synonym: "generation of hyperphosphorylated CTD of RNA polymerase II" EXACT [GOC:krc] synonym: "generation of II(0) form of RNA polymerase II" EXACT [GOC:krc] synonym: "hyperphosphorylation of RNA polymerase II C-terminal domain" EXACT [GOC:krc] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0006468 ! protein phosphorylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-07-13T04:01:19Z [Term] id: GO:0070827 name: chromatin maintenance namespace: biological_process def: "The chromatin organization process that preserves chromatin in a stable functional or structural state." [GOC:mah] is_a: GO:0006325 ! chromatin organization is_a: GO:0043954 ! cellular component maintenance is_a: GO:1902589 ! single-organism organelle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-07-23T04:09:59Z [Term] id: GO:0070828 name: heterochromatin organization namespace: biological_process def: "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin, a compact and highly condensed form of chromatin." [GOC:mah] synonym: "heterochromatin organisation" EXACT [GOC:mah] is_a: GO:0006325 ! chromatin organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-07-23T04:12:48Z [Term] id: GO:0070829 name: heterochromatin maintenance namespace: biological_process def: "The chromatin organization process that preserves heterochromatin in a stable functional or structural state." [GOC:mah] is_a: GO:0070827 ! chromatin maintenance is_a: GO:0070828 ! heterochromatin organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-07-23T04:14:49Z [Term] id: GO:0070838 name: divalent metal ion transport namespace: biological_process def: "The directed movement of divalent metal cations, any metal ion with a +2 electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] subset: gosubset_prok is_a: GO:0030001 ! metal ion transport is_a: GO:0072511 ! divalent inorganic cation transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-07-31T01:02:39Z [Term] id: GO:0070868 name: heterochromatin organization involved in chromatin silencing namespace: biological_process def: "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin and contributes to chromatin silencing." [GOC:mah] synonym: "heterochromatin organisation involved in chromatin silencing" EXACT [GOC:mah] is_a: GO:0070828 ! heterochromatin organization is_a: GO:0097549 ! chromatin organization involved in negative regulation of transcription intersection_of: GO:0070828 ! heterochromatin organization intersection_of: part_of GO:0006342 ! chromatin silencing relationship: part_of GO:0006342 ! chromatin silencing property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-08-20T12:45:52Z [Term] id: GO:0070869 name: heterochromatin assembly involved in chromatin silencing namespace: biological_process def: "Any process that results in the assembly of chromatin into heterochromatin and contributes to chromatin silencing." [GOC:mah] synonym: "heterochromatin formation involved in chromatin silencing" EXACT [] is_a: GO:0031507 ! heterochromatin assembly is_a: GO:0070868 ! heterochromatin organization involved in chromatin silencing intersection_of: GO:0031507 ! heterochromatin assembly intersection_of: part_of GO:0006342 ! chromatin silencing relationship: part_of GO:0006342 ! chromatin silencing property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-08-20T01:04:27Z [Term] id: GO:0070870 name: heterochromatin maintenance involved in chromatin silencing namespace: biological_process def: "A chromatin organization process that preserves heterochromatin in a stable functional or structural state, and that contributes to chromatin silencing." [GOC:mah] is_a: GO:0070829 ! heterochromatin maintenance is_a: GO:0070868 ! heterochromatin organization involved in chromatin silencing intersection_of: GO:0070829 ! heterochromatin maintenance intersection_of: part_of GO:0006342 ! chromatin silencing relationship: part_of GO:0006342 ! chromatin silencing property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-08-20T01:08:43Z [Term] id: GO:0070887 name: cellular response to chemical stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0042221 ! response to chemical is_a: GO:0051716 ! cellular response to stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-08-27T04:41:45Z [Term] id: GO:0070914 name: UV-damage excision repair namespace: biological_process def: "A DNA repair process that is initiated by an endonuclease that introduces a single-strand incision immediately 5' of a UV-induced damage site. UV-damage excision repair acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs)." [GOC:mah, PMID:9619100] synonym: "AER" RELATED [GOC:mah, PMID:10704216] synonym: "alternative excision repair" RELATED [GOC:mah, PMID:10704216] synonym: "UV-damaged DNA endonuclease-dependent excision repair" EXACT [GOC:vw] synonym: "UVDE-dependent excision repair" EXACT [GOC:vw, PMID:9619100] synonym: "UVER" EXACT [GOC:vw, PMID:9619100] is_a: GO:0006281 ! DNA repair is_a: GO:0034644 ! cellular response to UV property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-09-10T03:14:06Z [Term] id: GO:0070925 name: organelle assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] subset: goslim_yeast is_a: GO:0006996 ! organelle organization is_a: GO:0022607 ! cellular component assembly property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-09-15T03:00:51Z [Term] id: GO:0070938 name: contractile ring namespace: cellular_component def: "A cytoskeletal structure composed of filamentous protein that forms beneath the membrane of many cells or organelles, in the plane of cell or organelle division. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells or organelles." [GOC:mah, ISBN:0123645859, ISBN:0792354923, PMID:10791428, PMID:17913889] synonym: "constriction ring" RELATED [GOC:mah] synonym: "cytokinetic ring" RELATED [GOC:mah] is_a: GO:0044464 ! cell part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-09-22T02:41:32Z [Term] id: GO:0070972 name: protein localization to endoplasmic reticulum namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within the endoplasmic reticulum." [GOC:mah] synonym: "protein localisation in endoplasmic reticulum" EXACT [GOC:mah] synonym: "protein localization in endoplasmic reticulum" EXACT [GOC:curators] synonym: "protein localization in ER" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-10-02T12:43:34Z [Term] id: GO:0070990 name: snRNP binding namespace: molecular_function def: "Interacting selectively and non-covalently with any part of a small nuclear ribonucleoprotein particle." [GOC:BHF, GOC:mah, GOC:rl] is_a: GO:0043021 ! ribonucleoprotein complex binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-10-29T03:54:25Z [Term] id: GO:0071008 name: U2-type post-mRNA release spliceosomal complex namespace: cellular_component def: "A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and the U2, U5 and U6 snRNPs." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] synonym: "GT-AG post-mRNA release spliceosomal complex" NARROW [GOC:krc, GOC:mah] synonym: "major post-mRNA release spliceosomal complex" EXACT [GOC:krc, GOC:mah] synonym: "mammalian U2-type spliceosomal complex I" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "U2/U5/U6 snRNP complex" EXACT [GOC:mah, PMID:12374752, PMID:20400941, PMID:24442611] synonym: "U2/U5/U6 tri-snRNP complex" EXACT [GOC:mah, PMID:12374752, PMID:20400941] is_a: GO:0005684 ! U2-type spliceosomal complex is_a: GO:0071014 ! post-mRNA release spliceosomal complex relationship: has_part GO:0005686 ! U2 snRNP relationship: has_part GO:0005688 ! U6 snRNP property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-07-30T12:00:35Z [Term] id: GO:0071014 name: post-mRNA release spliceosomal complex namespace: cellular_component def: "A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, including U5." [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:19239890] synonym: "mammalian spliceosomal complex I" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005681 ! spliceosomal complex relationship: has_part GO:0005682 ! U5 snRNP property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-07-30T12:00:35Z [Term] id: GO:0071103 name: DNA conformation change namespace: biological_process def: "A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule." [GOC:mah] subset: gosubset_prok synonym: "DNA conformation modification" EXACT [GOC:mah] is_a: GO:0051276 ! chromosome organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-11-09T11:36:34Z [Term] id: GO:0071162 name: CMG complex namespace: cellular_component def: "A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication." [GOC:rb, PMID:19228417] synonym: "unwindosome" EXACT [PMID:19228417] is_a: GO:0031261 ! DNA replication preinitiation complex is_a: GO:0044454 ! nuclear chromosome part relationship: has_part GO:0000811 ! GINS complex relationship: has_part GO:0042555 ! MCM complex property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-11-19T11:04:13Z [Term] id: GO:0071166 name: ribonucleoprotein complex localization namespace: biological_process def: "Any process in which a ribonucleoprotein complex is transported to, or maintained in, a specific location within a cell." [GOC:mah] synonym: "cellular ribonucleoprotein complex localization" EXACT [GOC:mah] synonym: "establishment and maintenance of ribonucleoprotein complex localization" EXACT [GOC:mah] synonym: "ribonucleoprotein complex localisation" EXACT [GOC:mah] synonym: "RNP localization" EXACT [GOC:mah] is_a: GO:0051641 ! cellular localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-11-19T04:46:05Z [Term] id: GO:0071168 name: protein localization to chromatin namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin." [GOC:mah] synonym: "protein localisation to chromatin" EXACT [GOC:mah] is_a: GO:0034502 ! protein localization to chromosome property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-11-20T11:51:20Z [Term] id: GO:0071173 name: spindle assembly checkpoint namespace: biological_process def: "A cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mah] comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of spindle assembly checkpoint (mitotic or meiotic). subset: gocheck_do_not_manually_annotate synonym: "SAC" BROAD [GOC:mah] is_a: GO:0031577 ! spindle checkpoint property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-11-23T12:36:57Z [Term] id: GO:0071174 name: mitotic spindle checkpoint namespace: biological_process def: "A mitotic cell cycle checkpoint that originates from the spindle and delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and oriented, the completion of anaphase until chromosomes are attached to the spindle, or mitotic exit and cytokinesis when the spindle does not form." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of spindle checkpoint (assembly, orientation or Dma1-dependent). subset: gocheck_do_not_manually_annotate synonym: "mitotic cell cycle spindle checkpoint" EXACT [] is_a: GO:0007093 ! mitotic cell cycle checkpoint is_a: GO:0031577 ! spindle checkpoint is_a: GO:0045841 ! negative regulation of mitotic metaphase/anaphase transition intersection_of: GO:0031577 ! spindle checkpoint intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: negatively_regulates GO:0007091 ! metaphase/anaphase transition of mitotic cell cycle relationship: part_of GO:0000278 ! mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-11-23T12:41:36Z [Term] id: GO:0071214 name: cellular response to abiotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: gosubset_prok synonym: "cellular response to abiotic stress" NARROW [GOC:mah] is_a: GO:0009628 ! response to abiotic stimulus is_a: GO:0051716 ! cellular response to stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-03T01:02:11Z [Term] id: GO:0071216 name: cellular response to biotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "cellular response to biotic stress" NARROW [GOC:mah] is_a: GO:0009607 ! response to biotic stimulus is_a: GO:0051716 ! cellular response to stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-03T01:09:08Z [Term] id: GO:0071229 name: cellular response to acid chemical namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of the dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:go_curators, GOC:mah, http://en.wikipedia.org/wiki/Acid] comment: This term should be used to describe a response to a specific acid as a chemical. E.g., if a cell were responding to glutamate, then the response would be glutamate-specific; the cell is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0071468 'cellular response to acidic pH' instead. subset: gocheck_do_not_manually_annotate synonym: "cellular response to acid" BROAD [] synonym: "cellular response to acid anion" RELATED [] synonym: "cellular response to oxoanion" RELATED [] is_a: GO:0001101 ! response to acid chemical is_a: GO:0070887 ! cellular response to chemical stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-03T02:07:23Z [Term] id: GO:0071241 name: cellular response to inorganic substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus." [GOC:mah] subset: gosubset_prok is_a: GO:0010035 ! response to inorganic substance is_a: GO:0070887 ! cellular response to chemical stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-03T02:35:49Z [Term] id: GO:0071243 name: cellular response to arsenic-containing substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides." [GOC:mah] subset: gosubset_prok synonym: "cellular response to arsenic" EXACT [GOC:curators] is_a: GO:0046685 ! response to arsenic-containing substance is_a: GO:0070887 ! cellular response to chemical stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-03T02:41:05Z [Term] id: GO:0071248 name: cellular response to metal ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:mah] subset: gosubset_prok synonym: "cellular response to heavy metal" NARROW [GOC:mah] synonym: "cellular response to metal" EXACT [GOC:mah] is_a: GO:0010038 ! response to metal ion is_a: GO:0071241 ! cellular response to inorganic substance property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-03T02:46:31Z [Term] id: GO:0071276 name: cellular response to cadmium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus." [GOC:mah] subset: gosubset_prok synonym: "cellular response to cadmium" EXACT [GOC:mah] is_a: GO:0046686 ! response to cadmium ion is_a: GO:0071248 ! cellular response to metal ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-10T03:54:49Z [Term] id: GO:0071277 name: cellular response to calcium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus." [GOC:mah] synonym: "cellular response to Ca2+ ion" EXACT [GOC:mah] is_a: GO:0051592 ! response to calcium ion is_a: GO:0071248 ! cellular response to metal ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-10T03:55:01Z [Term] id: GO:0071280 name: cellular response to copper ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus." [GOC:mah] subset: gosubset_prok synonym: "cellular response to copper" EXACT [GOC:mah] is_a: GO:0046688 ! response to copper ion is_a: GO:0071248 ! cellular response to metal ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-10T03:57:03Z [Term] id: GO:0071281 name: cellular response to iron ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus." [GOC:mah] synonym: "cellular response to iron" EXACT [GOC:mah] is_a: GO:0010039 ! response to iron ion is_a: GO:0071248 ! cellular response to metal ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-10T03:57:22Z [Term] id: GO:0071288 name: cellular response to mercury ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus." [GOC:mah] subset: gosubset_prok synonym: "cellular response to mercuric ion" EXACT [GOC:mah] synonym: "cellular response to mercury" EXACT [GOC:mah] is_a: GO:0046689 ! response to mercury ion is_a: GO:0071248 ! cellular response to metal ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-10T04:06:37Z [Term] id: GO:0071292 name: cellular response to silver ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silver ion stimulus." [GOC:mah] is_a: GO:0010272 ! response to silver ion is_a: GO:0071248 ! cellular response to metal ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-10T04:16:30Z [Term] id: GO:0071294 name: cellular response to zinc ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus." [GOC:mah] synonym: "cellular response to zinc" EXACT [GOC:mah] is_a: GO:0010043 ! response to zinc ion is_a: GO:0071248 ! cellular response to metal ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-10T04:17:10Z [Term] id: GO:0071295 name: cellular response to vitamin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus." [GOC:mah] is_a: GO:0031670 ! cellular response to nutrient is_a: GO:0033273 ! response to vitamin property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-10T04:27:24Z [Term] id: GO:0071301 name: cellular response to vitamin B1 namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B1 stimulus." [GOC:mah] synonym: "cellular response to thiamin" EXACT [GOC:mah] synonym: "cellular response to thiamine" EXACT [GOC:mah] is_a: GO:0010266 ! response to vitamin B1 is_a: GO:0071295 ! cellular response to vitamin is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-10T04:32:09Z [Term] id: GO:0071310 name: cellular response to organic substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:mah] subset: gosubset_prok is_a: GO:0010033 ! response to organic substance is_a: GO:0070887 ! cellular response to chemical stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-10T04:46:04Z [Term] id: GO:0071312 name: cellular response to alkaloid namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active." [GOC:mah] is_a: GO:0043279 ! response to alkaloid is_a: GO:0071417 ! cellular response to organonitrogen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-10T04:50:58Z [Term] id: GO:0071313 name: cellular response to caffeine namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [GOC:mah] is_a: GO:0031000 ! response to caffeine is_a: GO:0071312 ! cellular response to alkaloid is_a: GO:0071415 ! cellular response to purine-containing compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-10T04:52:51Z [Term] id: GO:0071320 name: cellular response to cAMP namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus." [GOC:mah] synonym: "cellular response to 3',5' cAMP" EXACT [GOC:mah] synonym: "cellular response to 3',5'-cAMP" EXACT [GOC:mah] synonym: "cellular response to adenosine 3',5'-cyclophosphate" EXACT [GOC:mah] synonym: "cellular response to cyclic AMP" EXACT [GOC:mah] is_a: GO:0051591 ! response to cAMP is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:1901701 ! cellular response to oxygen-containing compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-10T05:12:15Z [Term] id: GO:0071322 name: cellular response to carbohydrate stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus." [GOC:mah] is_a: GO:0009743 ! response to carbohydrate is_a: GO:0071310 ! cellular response to organic substance is_a: GO:1901701 ! cellular response to oxygen-containing compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-10T05:13:33Z [Term] id: GO:0071326 name: cellular response to monosaccharide stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosaccharide stimulus." [GOC:mah] is_a: GO:0034284 ! response to monosaccharide is_a: GO:0071322 ! cellular response to carbohydrate stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-10T05:27:18Z [Term] id: GO:0071331 name: cellular response to hexose stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus." [GOC:mah] is_a: GO:0009746 ! response to hexose is_a: GO:0071326 ! cellular response to monosaccharide stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-10T05:37:00Z [Term] id: GO:0071333 name: cellular response to glucose stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:mah] is_a: GO:0001678 ! cellular glucose homeostasis is_a: GO:0009749 ! response to glucose is_a: GO:0071331 ! cellular response to hexose stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-10T05:38:03Z [Term] id: GO:0071362 name: cellular response to ether namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus." [GOC:mah] is_a: GO:0045472 ! response to ether is_a: GO:1901701 ! cellular response to oxygen-containing compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-11T03:03:22Z [Term] id: GO:0071407 name: cellular response to organic cyclic compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus." [GOC:mah] synonym: "cellular response to organic cyclic substance" EXACT [GOC:mah] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0071310 ! cellular response to organic substance property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-14T02:55:58Z [Term] id: GO:0071415 name: cellular response to purine-containing compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus." [CHEBI:26401, GOC:mah] synonym: "cellular response to purine" RELATED [GOC:curators] is_a: GO:0014074 ! response to purine-containing compound is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-14T03:12:20Z [Term] id: GO:0071417 name: cellular response to organonitrogen compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond." [CHEBI:35352, GOC:mah] synonym: "cellular response to organic nitrogen" EXACT [GOC:mah] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0071310 ! cellular response to organic substance is_a: GO:0071495 ! cellular response to endogenous stimulus is_a: GO:1901699 ! cellular response to nitrogen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-14T04:07:27Z [Term] id: GO:0071426 name: ribonucleoprotein complex export from nucleus namespace: biological_process def: "The directed movement of a ribonucleoprotein complex from the nucleus to the cytoplasm." [GOC:mah] synonym: "ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah] synonym: "ribonucleoprotein complex nucleus export" EXACT [GOC:mah] synonym: "ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah] synonym: "RNP export from nucleus" EXACT [GOC:mah] is_a: GO:0051168 ! nuclear export is_a: GO:1902582 ! single-organism intracellular transport relationship: has_part GO:0006405 ! RNA export from nucleus relationship: part_of GO:0071166 ! ribonucleoprotein complex localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-16T10:13:01Z [Term] id: GO:0071427 name: mRNA-containing ribonucleoprotein complex export from nucleus namespace: biological_process def: "The directed movement of a ribonucleoprotein complex that contains messenger RNA from the nucleus to the cytoplasm." [GOC:mah] synonym: "mRNA-containing ribonucleoprotein complex export from cell nucleus" EXACT [GOC:mah] synonym: "mRNA-containing ribonucleoprotein complex nucleus export" EXACT [GOC:mah] synonym: "mRNA-containing ribonucleoprotein complex transport from nucleus to cytoplasm" EXACT [GOC:mah] synonym: "mRNA-containing RNP export from nucleus" EXACT [GOC:mah] is_a: GO:0071426 ! ribonucleoprotein complex export from nucleus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-16T10:13:59Z [Term] id: GO:0071436 name: sodium ion export namespace: biological_process def: "The directed movement of sodium ions out of a cell or organelle." [GOC:mah] synonym: "sodium export" EXACT [GOC:mah] is_a: GO:0035725 ! sodium ion transmembrane transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-16T11:13:55Z [Term] id: GO:0071444 name: cellular response to pheromone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:mah] subset: gosubset_prok synonym: "cellular pheromone response" EXACT [GOC:mah] is_a: GO:0019236 ! response to pheromone is_a: GO:0071310 ! cellular response to organic substance property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-16T04:05:33Z [Term] id: GO:0071450 name: cellular response to oxygen radical namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion." [GOC:mah] subset: gosubset_prok is_a: GO:0000305 ! response to oxygen radical is_a: GO:0034614 ! cellular response to reactive oxygen species property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-16T04:38:52Z [Term] id: GO:0071451 name: cellular response to superoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion." [GOC:mah] subset: gosubset_prok is_a: GO:0000303 ! response to superoxide is_a: GO:0071450 ! cellular response to oxygen radical property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-16T04:39:14Z [Term] id: GO:0071453 name: cellular response to oxygen levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen." [GOC:mah] synonym: "cellular response to oxygen" RELATED [GOC:al] is_a: GO:0070482 ! response to oxygen levels is_a: GO:0070887 ! cellular response to chemical stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-16T04:43:59Z [Term] id: GO:0071456 name: cellular response to hypoxia namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:mah] comment: Note that this term should not be confused with 'cellular response to anoxia ; GO:0071454'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%. synonym: "cellular response to hypoxic stress" EXACT [GOC:mah] synonym: "cellular response to lowered oxygen tension" EXACT [GOC:mah] is_a: GO:0001666 ! response to hypoxia is_a: GO:0033554 ! cellular response to stress is_a: GO:0036294 ! cellular response to decreased oxygen levels property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-16T04:45:20Z [Term] id: GO:0071459 name: protein localization to chromosome, centromeric region namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, the centromeric region of a chromosome." [GOC:mah] synonym: "protein localisation to chromosome, centromeric region" EXACT [GOC:mah] synonym: "protein localization to centromere" EXACT [GOC:mah] synonym: "protein localization to chromosome, centric region" EXACT [GOC:mah] is_a: GO:0034502 ! protein localization to chromosome property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-17T02:11:23Z [Term] id: GO:0071462 name: cellular response to water stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water." [GOC:mah] subset: gosubset_prok is_a: GO:0009415 ! response to water is_a: GO:0071214 ! cellular response to abiotic stimulus is_a: GO:0071229 ! cellular response to acid chemical is_a: GO:1901701 ! cellular response to oxygen-containing compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-18T11:32:44Z [Term] id: GO:0071467 name: cellular response to pH namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:mah, http://en.wikipedia.org/wiki/PH] subset: gosubset_prok is_a: GO:0009268 ! response to pH is_a: GO:0071214 ! cellular response to abiotic stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-18T11:41:54Z [Term] id: GO:0071470 name: cellular response to osmotic stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah] subset: gosubset_prok synonym: "cellular osmotic response" EXACT [GOC:mah] synonym: "cellular osmotic stress response" EXACT [GOC:mah] is_a: GO:0006970 ! response to osmotic stress is_a: GO:0033554 ! cellular response to stress is_a: GO:0071214 ! cellular response to abiotic stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-18T11:45:33Z [Term] id: GO:0071471 name: cellular response to non-ionic osmotic stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of non-ionic solutes (e.g. mannitol, sorbitol) in the environment." [GOC:mah] is_a: GO:0010335 ! response to non-ionic osmotic stress is_a: GO:0071470 ! cellular response to osmotic stress property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-18T11:47:59Z [Term] id: GO:0071472 name: cellular response to salt stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mah] subset: gosubset_prok synonym: "cellular response to ionic osmotic stress" EXACT [GOC:mah] synonym: "cellular salinity response" EXACT [GOC:mah] is_a: GO:0009651 ! response to salt stress is_a: GO:0071470 ! cellular response to osmotic stress property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-18T11:48:23Z [Term] id: GO:0071474 name: cellular hyperosmotic response namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell." [GOC:mah] synonym: "cellular HOG response" EXACT [GOC:mah] synonym: "cellular hypertonic response" EXACT [GOC:mah] synonym: "cellular response to hypertonicity" EXACT [GOC:mah, GOC:yaf] is_a: GO:0006972 ! hyperosmotic response is_a: GO:0071470 ! cellular response to osmotic stress property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-18T11:51:36Z [Term] id: GO:0071476 name: cellular hypotonic response namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell." [GOC:mah] synonym: "cellular hypo-osmotic response" EXACT [GOC:mah] is_a: GO:0006971 ! hypotonic response is_a: GO:0071470 ! cellular response to osmotic stress property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-18T11:52:59Z [Term] id: GO:0071477 name: cellular hypotonic salinity response namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:mah] synonym: "cellular response to hypotonic salt stress" EXACT [GOC:mah] is_a: GO:0042539 ! hypotonic salinity response is_a: GO:0071472 ! cellular response to salt stress is_a: GO:0071476 ! cellular hypotonic response property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-18T11:53:20Z [Term] id: GO:0071478 name: cellular response to radiation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:mah] comment: Note that 'radiation' refers to electromagnetic radiation of any wavelength. subset: gosubset_prok synonym: "cellular response to electromagnetic radiation stimulus" EXACT [GOC:mah] synonym: "cellular response to radiation stimulus" EXACT [GOC:mah] is_a: GO:0009314 ! response to radiation is_a: GO:0071214 ! cellular response to abiotic stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-18T01:59:37Z [Term] id: GO:0071479 name: cellular response to ionizing radiation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [GOC:mah] synonym: "cellular response to ionising radiation" EXACT [GOC:mah] synonym: "cellular response to ionizing radiation stimulus" EXACT [GOC:mah] is_a: GO:0010212 ! response to ionizing radiation is_a: GO:0071478 ! cellular response to radiation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-18T02:00:31Z [Term] id: GO:0071480 name: cellular response to gamma radiation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:mah] synonym: "cellular response to gamma ray" RELATED [GOC:mah] synonym: "cellular response to gamma-ray photon" RELATED [GOC:mah] is_a: GO:0010332 ! response to gamma radiation is_a: GO:0071479 ! cellular response to ionizing radiation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-18T02:00:50Z [Term] id: GO:0071482 name: cellular response to light stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:mah] subset: gosubset_prok is_a: GO:0009416 ! response to light stimulus is_a: GO:0071478 ! cellular response to radiation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-18T02:03:49Z [Term] id: GO:0071495 name: cellular response to endogenous stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: gosubset_prok is_a: GO:0009719 ! response to endogenous stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-18T02:25:40Z [Term] id: GO:0071496 name: cellular response to external stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: gosubset_prok synonym: "cellular response to environmental stimulus" EXACT [GOC:mah] is_a: GO:0009605 ! response to external stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-18T02:36:52Z [Term] id: GO:0071497 name: cellular response to freezing namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius." [GOC:mah] subset: gosubset_prok synonym: "antifreeze activity" RELATED [GOC:mah] synonym: "ice nucleation inhibitor activity" RELATED [GOC:mah] is_a: GO:0050826 ! response to freezing is_a: GO:0070417 ! cellular response to cold property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-18T02:41:02Z [Term] id: GO:0071500 name: cellular response to nitrosative stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions." [GOC:mah] is_a: GO:0033554 ! cellular response to stress is_a: GO:0051409 ! response to nitrosative stress property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2009-12-18T02:49:46Z [Term] id: GO:0071514 name: genetic imprinting namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules by a mechanism that is mediated by DNA, is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence." [GOC:mah, GOC:vw] synonym: "DNA imprinting" EXACT [GOC:mah] is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-01-06T11:56:31Z [Term] id: GO:0071515 name: genetic imprinting at mating-type locus namespace: biological_process def: "A genetic imprinting process in which a stable single-strand DNA lesion triggers programmed gene conversion at the mating-type locus, thereby restricting mating-type interconversion to one of the two sister chromatids during DNA replication." [GOC:mah, PMID:14765111, PMID:18723894] synonym: "mating type determination, imprinting" EXACT [GOC:vw] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0031494 ! regulation of mating type switching is_a: GO:0071514 ! genetic imprinting property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-01-06T12:58:56Z [Term] id: GO:0071554 name: cell wall organization or biogenesis namespace: biological_process alt_id: GO:0070882 def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cell wall." [GOC:mah] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "cell wall organisation or biogenesis" EXACT [GOC:mah] synonym: "cell wall organization or biogenesis at cellular level" EXACT [GOC:mah] synonym: "cellular cell wall organisation or biogenesis" EXACT [GOC:mah] synonym: "cellular cell wall organization or biogenesis" EXACT [] is_a: GO:0009987 ! cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-01-13T03:19:38Z [Term] id: GO:0071555 name: cell wall organization namespace: biological_process alt_id: GO:0007047 alt_id: GO:0044234 def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:mah] subset: goslim_candida subset: goslim_pir subset: gosubset_prok synonym: "cell wall organisation" EXACT [GOC:curators] synonym: "cell wall organisation in other organism" EXACT [GOC:mah] synonym: "cell wall organization and biogenesis" RELATED [GOC:mah] synonym: "cell wall organization at cellular level" EXACT [GOC:mah] synonym: "cell wall organization in other organism" EXACT [] synonym: "cellular cell wall organisation" EXACT [GOC:curators] synonym: "cellular cell wall organization" EXACT [] is_a: GO:0045229 ! external encapsulating structure organization is_a: GO:0071554 ! cell wall organization or biogenesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-01-13T03:33:07Z [Term] id: GO:0071574 name: protein localization to medial cortex namespace: biological_process def: "A process in which a protein is transported to, or maintained in, the medial cortex." [GOC:mah] synonym: "protein localisation to medial cortex" EXACT [GOC:mah] is_a: GO:0072697 ! protein localization to cell cortex is_a: GO:0072741 ! protein localization to cell division site property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-01-26T05:17:50Z [Term] id: GO:0071596 name: ubiquitin-dependent protein catabolic process via the N-end rule pathway namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the N-end rule pathway. In the N-end rule pathway, destabilizing N-terminal residues (N-degrons) in substrates are recognized by E3 ligases (N-recognins), whereupon the substrates are linked to ubiquitin and then delivered to the proteasome for degradation." [GOC:mah, GOC:rb, PMID:19246002, PMID:9112437] synonym: "ubiquitin-dependent protein breakdown via the N-end rule pathway" EXACT [GOC:mah] synonym: "ubiquitin-dependent protein catabolism via the N-end rule pathway" EXACT [GOC:mah] synonym: "ubiquitin-dependent protein degradation via the N-end rule pathway" EXACT [GOC:mah] is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-01-29T03:01:09Z [Term] id: GO:0071619 name: phosphorylation of RNA polymerase II C-terminal domain serine 2 residues namespace: biological_process def: "The process of introducing a phosphate group onto a serine residue at position 2 within the heptapeptide repeat (YSPTSPS) of the C-terminal domain of RNA polymerase II. Typically, phosphorylation of serine 2 (Ser2) occurs subsequent to phosphorylation of serine 5 and is thus seen in the middle and 3' ends of genes. In vivo, Ser2 phosphorylation is primarily performed by CTDK-I in S. cerevisiae or CDK9 in metazoans." [GOC:krc, PMID:17079683] is_a: GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-02-09T02:37:02Z [Term] id: GO:0071620 name: phosphorylation of RNA polymerase II C-terminal domain serine 5 residues namespace: biological_process def: "The process of introducing a phosphate group onto a serine residue at position 5 within the heptapeptide repeat (YSPTSPS) of the C-terminal domain of RNA polymerase II. Typically, phosphorylation of serine 5 (Ser5) occurs near the 5' ends of genes. It is generally still observed in the middle of genes, overlapping with phosphorylation of serine 2, but is generally not present at the 3' ends of genes. In vivo, Ser5 phosphorylation occurs primarily through the action of TFIIH (KIN28 in S. cerevisiae, CKD7 in metazoans)." [GOC:krc, PMID:17079683] is_a: GO:0070816 ! phosphorylation of RNA polymerase II C-terminal domain property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-02-09T02:39:52Z [Term] id: GO:0071686 name: horsetail nucleus namespace: cellular_component def: "The elongated nucleus which forms during the rapid oscillatory movement at meiotic prophase; characterized in Schizosaccharomyces pombe." [GOC:vw, PMID:15030757] is_a: GO:0005634 ! nucleus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-02-22T04:52:01Z [Term] id: GO:0071702 name: organic substance transport namespace: biological_process def: "The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon." [CHEBI:50860, GOC:mah] is_a: GO:0006810 ! transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-03-08T02:15:14Z [Term] id: GO:0071703 name: detection of organic substance namespace: biological_process def: "The series of events in which an organic substance stimulus is received by a cell and converted into a molecular signal." [GOC:mah] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0010033 ! response to organic substance property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-03-08T03:18:44Z [Term] id: GO:0071704 name: organic substance metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon." [CHEBI:50860, GOC:mah] synonym: "organic molecular entity metabolic process" EXACT [] synonym: "organic molecular entity metabolism" EXACT [] synonym: "organic substance metabolism" EXACT [] is_a: GO:0008152 ! metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-03-08T03:32:18Z [Term] id: GO:0071705 name: nitrogen compound transport namespace: biological_process def: "The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:51143, GOC:mah] is_a: GO:0006810 ! transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-03-08T03:56:28Z [Term] id: GO:0071709 name: membrane assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a membrane." [GOC:mah] is_a: GO:0022607 ! cellular component assembly is_a: GO:0044802 ! single-organism membrane organization relationship: part_of GO:0044091 ! membrane biogenesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-03-10T11:19:17Z [Term] id: GO:0071731 name: response to nitric oxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus." [GOC:mah, GOC:yaf] is_a: GO:0000302 ! response to reactive oxygen species is_a: GO:0010035 ! response to inorganic substance is_a: GO:1901698 ! response to nitrogen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-03-17T04:03:38Z [Term] id: GO:0071732 name: cellular response to nitric oxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus." [GOC:mah, GOC:yaf] is_a: GO:0034614 ! cellular response to reactive oxygen species is_a: GO:0071241 ! cellular response to inorganic substance is_a: GO:0071731 ! response to nitric oxide is_a: GO:1902170 ! cellular response to reactive nitrogen species property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-03-17T04:12:52Z [Term] id: GO:0071789 name: spindle pole body localization to nuclear envelope namespace: biological_process def: "A process in which a spindle pole body is transported to, or maintained in, a specific location in the nuclear envelope. A spindle pole body is a type of microtubule organizing center found in fungal cells." [GOC:mah, PMID:20434336] synonym: "spindle pole body anchorage" EXACT [GOC:vw] synonym: "spindle pole body docking" EXACT [GOC:vw] synonym: "spindle pole body localisation in nuclear envelope" EXACT [GOC:mah] synonym: "spindle pole body localization in nuclear envelope" EXACT [GOC:curators] is_a: GO:0070631 ! spindle pole body localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-09-01T02:22:44Z [Term] id: GO:0071790 name: establishment of spindle pole body localization to nuclear envelope namespace: biological_process def: "A process in which a spindle pole body is transported to a specific location in the nuclear envelope. A spindle pole body is a type of microtubule organizing center found in fungal cells." [GOC:mah, PMID:20434336] synonym: "establishment of spindle pole body localisation in nuclear envelope" EXACT [GOC:mah] synonym: "establishment of spindle pole body localization in nuclear envelope" EXACT [GOC:curators] is_a: GO:0070632 ! establishment of spindle pole body localization is_a: GO:0071789 ! spindle pole body localization to nuclear envelope property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-09-01T02:25:44Z [Term] id: GO:0071822 name: protein complex subunit organization namespace: biological_process def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex." [GOC:mah] synonym: "protein complex subunit organisation" EXACT [GOC:mah] is_a: GO:0043933 ! macromolecular complex subunit organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-09-08T10:01:42Z [Term] id: GO:0071824 name: protein-DNA complex subunit organization namespace: biological_process def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA complex." [GOC:mah] synonym: "DNA-protein complex subunit organization" EXACT [GOC:mah] synonym: "protein-DNA complex subunit organisation" EXACT [GOC:mah] is_a: GO:0043933 ! macromolecular complex subunit organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-09-08T10:03:26Z [Term] id: GO:0071826 name: ribonucleoprotein complex subunit organization namespace: biological_process def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex." [GOC:mah] synonym: "protein-RNA complex subunit organization" EXACT [GOC:mah] synonym: "ribonucleoprotein complex subunit organisation" EXACT [GOC:mah] synonym: "RNA-protein complex subunit organization" EXACT [GOC:mah] is_a: GO:0043933 ! macromolecular complex subunit organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-09-08T10:10:35Z [Term] id: GO:0071840 name: cellular component organization or biogenesis namespace: biological_process alt_id: GO:0071841 def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:mah] synonym: "cellular component organisation or biogenesis" EXACT [GOC:mah] synonym: "cellular component organisation or biogenesis at cellular level" EXACT [GOC:mah] synonym: "cellular component organization or biogenesis at cellular level" EXACT [] is_a: GO:0008150 ! biological_process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-09-10T01:39:16Z [Term] id: GO:0071850 name: mitotic cell cycle arrest namespace: biological_process def: "The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M)." [GOC:mah] synonym: "arrest of mitotic cell cycle progression" EXACT [GOC:mah] synonym: "cessation of mitotic cell cycle" EXACT [GOC:mah] synonym: "termination of mitotic cell cycle" EXACT [GOC:mah] is_a: GO:0007050 ! cell cycle arrest property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-09-10T02:56:30Z [Term] id: GO:0071852 name: fungal-type cell wall organization or biogenesis namespace: biological_process def: "A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a fungal-type cell wall." [GOC:mah] synonym: "fungal-type cell wall organisation or biogenesis" EXACT [GOC:mah] synonym: "fungal-type cell wall organization and biogenesis" RELATED [GOC:mah] is_a: GO:0071554 ! cell wall organization or biogenesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-09-10T03:07:55Z [Term] id: GO:0071889 name: 14-3-3 protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxyl terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins." [GOC:cna, GOC:mah, InterPro:IPR000308, PMID:15167810, PMID:19575580, PR:000003237] is_a: GO:0005515 ! protein binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-09-14T01:21:50Z [Term] id: GO:0071894 name: histone H2B conserved C-terminal lysine ubiquitination namespace: biological_process def: "A histone ubiquitination process in which a ubiquitin monomer is added to a conserved lysine residue in the C-terminus of histone H2B. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, or K120 in mammals." [GOC:mah, GOC:vw] synonym: "budding yeast H2B K123 ubiquitination" NARROW [GOC:vw] synonym: "fission yeast H2B K119 ubiquitination" NARROW [GOC:vw] synonym: "mammalian H2B K120 ubiquitination" NARROW [GOC:vw] is_a: GO:0033523 ! histone H2B ubiquitination property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-09-14T03:43:46Z [Term] id: GO:0071897 name: DNA biosynthetic process namespace: biological_process def: "The cellular DNA metabolic process resulting in the formation of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:mah] subset: gosubset_prok synonym: "DNA anabolism" EXACT [GOC:mah] synonym: "DNA biosynthesis" EXACT [GOC:mah] synonym: "DNA formation" EXACT [GOC:mah] synonym: "DNA synthesis" EXACT [GOC:mah] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0034645 ! cellular macromolecule biosynthetic process is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-09-15T02:14:33Z [Term] id: GO:0071932 name: replication fork reversal namespace: biological_process def: "Replication fork processing that involves the unwinding of blocked forks to form four-stranded structures resembling Holliday junctions, which are subsequently resolved." [PMID:19406929] is_a: GO:0031297 ! replication fork processing property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-09-29T02:34:22Z [Term] id: GO:0071940 name: fungal-type cell wall assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a fungal-type cell wall." [GOC:mah, GOC:vw, PMID:19646873] synonym: "fungal-type cell wall formation" RELATED [GOC:mah] is_a: GO:0031505 ! fungal-type cell wall organization is_a: GO:0070726 ! cell wall assembly relationship: part_of GO:0009272 ! fungal-type cell wall biogenesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-09-30T04:59:36Z [Term] id: GO:0071944 name: cell periphery namespace: cellular_component def: "The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures." [GOC:mah] is_a: GO:0044464 ! cell part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-10-04T01:51:47Z [Term] id: GO:0071962 name: mitotic sister chromatid cohesion, centromeric namespace: biological_process def: "The cell cycle process in which centromeres of sister chromatids are joined during mitosis." [GOC:mah] synonym: "centromeric mitotic sister chromatin cohesion" EXACT [GOC:mah] synonym: "mitotic sister chromatid cohesion at centromere" EXACT [GOC:mah] synonym: "sister chromatid cohesion at centromere at mitosis" EXACT [GOC:mah] is_a: GO:0007064 ! mitotic sister chromatid cohesion is_a: GO:0070601 ! centromeric sister chromatid cohesion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2011-06-02T11:24:17Z [Term] id: GO:0071985 name: multivesicular body sorting pathway namespace: biological_process def: "A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded." [GOC:mah, PMID:17603537] is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0044765 ! single-organism transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-10-22T12:04:16Z [Term] id: GO:0071988 name: protein localization to spindle pole body namespace: biological_process def: "A process in which a protein is transported to, or maintained at, the spindle pole body." [GOC:mah] synonym: "protein localisation to spindle pole body" EXACT [GOC:mah] is_a: GO:0072698 ! protein localization to microtubule cytoskeleton property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-10-25T10:56:33Z [Term] id: GO:0071998 name: ascospore release from ascus namespace: biological_process def: "A developmental process that results in the discharge of ascospores from the ascus. Ascospore release may be active or passive." [DOI:10.1016/S0953-7562(96)80057-8, GOC:mah] synonym: "ascospore liberation" EXACT [DOI:10.1016/S0953-7562(96)80057-8] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0044702 ! single organism reproductive process is_a: GO:0048869 ! cellular developmental process is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0043935 ! sexual sporulation resulting in formation of a cellular spore property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-10-25T03:41:44Z [Term] id: GO:0071999 name: extracellular polysaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of polysaccharides used in extracellular structures." [GOC:mah, GOC:vw] subset: gosubset_prok synonym: "extracellular polysaccharide breakdown" EXACT [GOC:mah] synonym: "extracellular polysaccharide catabolism" EXACT [GOC:mah] synonym: "extracellular polysaccharide degradation" EXACT [GOC:mah] is_a: GO:0044247 ! cellular polysaccharide catabolic process is_a: GO:0046379 ! extracellular polysaccharide metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-10-25T05:11:25Z [Term] id: GO:0072330 name: monocarboxylic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group." [CHEBI:25384, GOC:mah] synonym: "monocarboxylic acid anabolism" EXACT [GOC:mah] synonym: "monocarboxylic acid biosynthesis" EXACT [GOC:mah] synonym: "monocarboxylic acid formation" EXACT [GOC:mah] synonym: "monocarboxylic acid synthesis" EXACT [GOC:mah] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-11-02T04:51:32Z [Term] id: GO:0072334 name: UDP-galactose transmembrane transport namespace: biological_process def: "The directed movement of UDP-galactose across a membrane into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "UDP-galactose membrane transport" EXACT [] is_a: GO:0015785 ! UDP-galactose transport is_a: GO:0034219 ! carbohydrate transmembrane transport is_a: GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport is_a: GO:0098656 ! anion transmembrane transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-11-03T02:03:36Z [Term] id: GO:0072337 name: modified amino acid transport namespace: biological_process def: "The directed movement of modified amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:83821, GOC:mah] synonym: "amino acid derivative transport" EXACT [] is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-11-04T12:18:23Z [Term] id: GO:0072348 name: sulfur compound transport namespace: biological_process def: "The directed movement of compounds that contain sulfur, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "sulfur-containing compound transport" EXACT [GOC:mah] is_a: GO:0044765 ! single-organism transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-11-11T11:43:56Z [Term] id: GO:0072384 name: organelle transport along microtubule namespace: biological_process def: "The directed movement of an organelle along a microtubule, mediated by motor proteins. This process begins with the attachment of an organelle to a microtubule, and ends when the organelle reaches its final destination." [GOC:mah] synonym: "microtubule-based organelle localization" EXACT [GOC:rl] is_a: GO:0010970 ! microtubule-based transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-12-01T04:59:11Z [Term] id: GO:0072393 name: microtubule anchoring at microtubule organizing center namespace: biological_process def: "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a microtubule organizing center." [GOC:BHF, PMID:19825938] synonym: "microtubule anchoring at microtubule organising centre" EXACT [GOC:mah] synonym: "microtubule anchoring at MTOC" EXACT [GOC:BHF] is_a: GO:0034453 ! microtubule anchoring property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-12-07T11:54:35Z [Term] id: GO:0072396 name: response to cell cycle checkpoint signaling namespace: biological_process alt_id: GO:0072405 alt_id: GO:0072408 def: "A process that occurs in response to signals generated as a result of cell cycle checkpoint signaling." [GOC:mtg_cell_cycle] synonym: "cell cycle checkpoint effector process" EXACT [GOC:mah] synonym: "G1/S transition checkpoint effector process" RELATED [GOC:mah] synonym: "G2/M transition checkpoint effector process" RELATED [GOC:mah] synonym: "response to G1/S transition checkpoint signaling" RELATED [] synonym: "response to G2/M transition checkpoint signaling" RELATED [] synonym: "response to signal involved in cell cycle checkpoint" EXACT [GOC:mah] synonym: "response to signal involved in G1/S transition checkpoint" RELATED [GOC:mah] synonym: "response to signal involved in G2/M transition checkpoint" RELATED [GOC:mah] is_a: GO:0071216 ! cellular response to biotic stimulus is_a: GO:0071495 ! cellular response to endogenous stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-12-08T03:05:46Z [Term] id: GO:0072402 name: response to DNA integrity checkpoint signaling namespace: biological_process def: "A process that occurs in response to signals generated as a result of DNA integrity checkpoint signaling." [GOC:mtg_cell_cycle] synonym: "DNA integrity checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in DNA integrity checkpoint" EXACT [GOC:mah] is_a: GO:0072396 ! response to cell cycle checkpoint signaling property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-12-08T03:32:17Z [Term] id: GO:0072414 name: response to mitotic cell cycle checkpoint signaling namespace: biological_process alt_id: GO:0072455 alt_id: GO:0072473 def: "A process that occurs in response to signals generated as a result of mitotic cell cycle checkpoint signaling." [GOC:mtg_cell_cycle] synonym: "mitotic cell cycle checkpoint effector process" EXACT [GOC:mah] synonym: "mitotic cell cycle G1/S checkpoint effector process" RELATED [GOC:mah] synonym: "mitotic G2/M transition checkpoint effector process" RELATED [GOC:mah] synonym: "response to mitotic cell cycle G1/S checkpoint signaling" RELATED [] synonym: "response to mitotic G2/M transition checkpoint signal" RELATED [] synonym: "response to signal involved in mitotic cell cycle checkpoint" RELATED [GOC:mah] synonym: "response to signal involved in mitotic cell cycle G1/S checkpoint" RELATED [GOC:mah] synonym: "response to signal involved in mitotic G2/M transition checkpoint" RELATED [GOC:mah] is_a: GO:0072396 ! response to cell cycle checkpoint signaling property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-12-08T03:50:43Z [Term] id: GO:0072417 name: response to spindle checkpoint signaling namespace: biological_process def: "A process that occurs in response to signals generated as a result of spindle checkpoint signaling." [GOC:mtg_cell_cycle] synonym: "response to signal involved in spindle checkpoint" EXACT [GOC:mah] synonym: "spindle checkpoint effector process" EXACT [GOC:mah] is_a: GO:0072396 ! response to cell cycle checkpoint signaling property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-12-08T03:56:04Z [Term] id: GO:0072423 name: response to DNA damage checkpoint signaling namespace: biological_process def: "A process that occurs in response to signals generated as a result of DNA damage checkpoint signaling." [GOC:mtg_cell_cycle] synonym: "DNA damage checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in DNA damage checkpoint" EXACT [GOC:mah] is_a: GO:0072402 ! response to DNA integrity checkpoint signaling property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-12-08T04:20:25Z [Term] id: GO:0072426 name: response to G2 DNA damage checkpoint signaling namespace: biological_process def: "A process that occurs in response to signals generated as a result of G2/M transition DNA damage checkpoint signaling." [GOC:mtg_cell_cycle] synonym: "G2/M transition DNA damage checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in G2/M transition DNA damage checkpoint" EXACT [GOC:mah] is_a: GO:0072423 ! response to DNA damage checkpoint signaling property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-12-08T04:26:35Z [Term] id: GO:0072429 name: response to intra-S DNA damage checkpoint signaling namespace: biological_process def: "A process that occurs in response to signals generated as a result of intra-S DNA damage checkpoint signaling." [GOC:mtg_cell_cycle] synonym: "intra-S DNA damage checkpoint effector process" EXACT [GOC:mah] synonym: "response to signal involved in intra-S DNA damage checkpoint" EXACT [GOC:mah] is_a: GO:0072423 ! response to DNA damage checkpoint signaling property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-12-08T04:31:56Z [Term] id: GO:0072435 name: response to mitotic G2 DNA damage checkpoint signaling namespace: biological_process alt_id: GO:0072458 def: "A process that occurs in response to signals generated as a result of mitotic G2/M transition DNA damage checkpoint signaling." [GOC:mtg_cell_cycle] synonym: "mitotic G2/M transition decatenation checkpoint effector process" RELATED [GOC:mah] synonym: "mitotic G2/M transition DNA damage checkpoint effector process" EXACT [GOC:mah] synonym: "response to mitotic G2/M transition decatenation checkpoint signaling" RELATED [] synonym: "response to mitotic G2/M transition DNA damage checkpoint signaling" EXACT [] synonym: "response to signal involved in mitotic G2/M transition decatenation checkpoint" RELATED [GOC:mah] synonym: "response to signal involved in mitotic G2/M transition DNA damage checkpoint" EXACT [GOC:mah] is_a: GO:0072414 ! response to mitotic cell cycle checkpoint signaling is_a: GO:0072426 ! response to G2 DNA damage checkpoint signaling property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-12-08T04:44:01Z [Term] id: GO:0072476 name: response to mitotic spindle checkpoint signaling namespace: biological_process def: "A process that occurs in response to signals generated as a result of mitotic cell cycle spindle checkpoint signaling." [GOC:mtg_cell_cycle] synonym: "mitotic cell cycle spindle checkpoint effector process" EXACT [GOC:mah] synonym: "response to mitotic cell cycle spindle checkpoint signaling" EXACT [] synonym: "response to signal involved in mitotic cell cycle spindle checkpoint" EXACT [GOC:mah] is_a: GO:0072414 ! response to mitotic cell cycle checkpoint signaling is_a: GO:0072417 ! response to spindle checkpoint signaling property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-12-09T11:50:09Z [Term] id: GO:0072511 name: divalent inorganic cation transport namespace: biological_process def: "The directed movement of inorganic cations with a valency of two into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage." [GOC:mah] subset: gosubset_prok is_a: GO:0006812 ! cation transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-12-16T04:11:02Z [Term] id: GO:0072512 name: trivalent inorganic cation transport namespace: biological_process def: "The directed movement of inorganic cations with a valency of three into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage." [GOC:mah] subset: gosubset_prok is_a: GO:0006812 ! cation transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-12-16T04:12:40Z [Term] id: GO:0072521 name: purine-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [CHEBI:26401, GOC:mah] synonym: "purine and derivative metabolic process" EXACT [GOC:curators] synonym: "purine-containing compound metabolism" EXACT [GOC:mah] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2011-01-04T03:03:59Z [Term] id: GO:0072522 name: purine-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof." [CHEBI:26401, GOC:mah] synonym: "purine and derivative biosynthetic process" EXACT [GOC:curators] synonym: "purine-containing compound anabolism" EXACT [GOC:mah] synonym: "purine-containing compound biosynthesis" EXACT [GOC:mah] synonym: "purine-containing compound formation" EXACT [GOC:mah] synonym: "purine-containing compound synthesis" EXACT [GOC:mah] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0072521 ! purine-containing compound metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2011-01-04T03:15:29Z [Term] id: GO:0072524 name: pyridine-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [CHEBI:26421, GOC:mah] synonym: "pyridine and derivative metabolic process" EXACT [GOC:curators] synonym: "pyridine-containing compound metabolism" EXACT [GOC:mah] is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2011-01-04T03:21:47Z [Term] id: GO:0072525 name: pyridine-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pyridine-containing compound, i.e. any compound that contains pyridine or a formal derivative thereof." [CHEBI:26421, GOC:mah] synonym: "pyridine and derivative biosynthetic process" EXACT [GOC:curators] synonym: "pyridine-containing compound anabolism" EXACT [GOC:mah] synonym: "pyridine-containing compound biosynthesis" EXACT [GOC:mah] synonym: "pyridine-containing compound formation" EXACT [GOC:mah] synonym: "pyridine-containing compound synthesis" EXACT [GOC:mah] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0072524 ! pyridine-containing compound metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2011-01-04T03:23:01Z [Term] id: GO:0072527 name: pyrimidine-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof." [CHEBI:39447, GOC:mah] synonym: "pyrimidine and derivative metabolic process" EXACT [GOC:curators] synonym: "pyrimidine-containing compound metabolism" EXACT [GOC:mah] is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2011-01-04T03:27:19Z [Term] id: GO:0072528 name: pyrimidine-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pyrimidine-containing compound, i.e. any compound that contains pyrimidine or a formal derivative thereof." [CHEBI:39447, GOC:mah] synonym: "pyrimidine and derivative biosynthetic process" EXACT [GOC:curators] synonym: "pyrimidine-containing compound anabolism" EXACT [GOC:mah] synonym: "pyrimidine-containing compound biosynthesis" EXACT [GOC:mah] synonym: "pyrimidine-containing compound formation" EXACT [GOC:mah] synonym: "pyrimidine-containing compound synthesis" EXACT [GOC:mah] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0072527 ! pyrimidine-containing compound metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2011-01-04T03:27:36Z [Term] id: GO:0072531 name: pyrimidine-containing compound transmembrane transport namespace: biological_process def: "The directed movement of a pyrimidine-containing compound across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof." [CHEBI:39447, GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "pyrimidine-containing compound membrane transport" EXACT [] is_a: GO:0055085 ! transmembrane transport is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2011-01-05T01:47:22Z [Term] id: GO:0072593 name: reactive oxygen species metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers." [CHEBI:26523, GOC:mah] synonym: "reactive oxygen species metabolism" EXACT [GOC:mah] synonym: "ROS metabolic process" EXACT [CHEBI:26523, GOC:mah] is_a: GO:0044237 ! cellular metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2011-02-11T10:50:06Z [Term] id: GO:0072594 name: establishment of protein localization to organelle namespace: biological_process def: "The directed movement of a protein to a specific location on or in an organelle. Encompasses establishment of localization in the membrane or lumen of a membrane-bounded organelle." [GOC:mah] synonym: "establishment of protein localisation to organelle" EXACT [GOC:mah] is_a: GO:0045184 ! establishment of protein localization relationship: part_of GO:0033365 ! protein localization to organelle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2011-02-14T01:56:51Z [Term] id: GO:0072599 name: establishment of protein localization to endoplasmic reticulum namespace: biological_process def: "The directed movement of a protein to a specific location in the endoplasmic reticulum." [GOC:mah] synonym: "establishment of protein localisation to endoplasmic reticulum" EXACT [GOC:mah] synonym: "establishment of protein localisation to ER" EXACT [GOC:mah] synonym: "establishment of protein localization in endoplasmic reticulum" EXACT [GOC:curators] synonym: "establishment of protein localization to ER" EXACT [GOC:mah] is_a: GO:0072594 ! establishment of protein localization to organelle relationship: part_of GO:0070972 ! protein localization to endoplasmic reticulum property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2011-02-14T02:23:41Z [Term] id: GO:0072657 name: protein localization to membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a specific location in a membrane." [GOC:mah] synonym: "protein localisation in membrane" EXACT [GOC:mah] synonym: "protein localization in membrane" EXACT [GOC:curators] is_a: GO:0034613 ! cellular protein localization is_a: GO:0044802 ! single-organism membrane organization is_a: GO:1902580 ! single-organism cellular localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2011-02-14T02:35:18Z [Term] id: GO:0072659 name: protein localization to plasma membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane." [GOC:mah] synonym: "protein localisation in plasma membrane" EXACT [GOC:mah] synonym: "protein localization in plasma membrane" EXACT [GOC:curators] is_a: GO:0007009 ! plasma membrane organization is_a: GO:0072657 ! protein localization to membrane is_a: GO:1990778 ! protein localization to cell periphery property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2011-02-14T02:43:05Z [Term] id: GO:0072665 name: protein localization to vacuole namespace: biological_process def: "A process in which a protein is transported to, or maintained at, a location in a vacuole." [GOC:ecd] synonym: "protein localisation to vacuole" EXACT [GOC:mah] is_a: GO:0033365 ! protein localization to organelle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2011-02-14T02:55:35Z [Term] id: GO:0072666 name: establishment of protein localization to vacuole namespace: biological_process def: "The directed movement of a protein to a specific location in a vacuole." [GOC:mah] synonym: "establishment of protein localisation to vacuole" EXACT [GOC:mah] is_a: GO:0072594 ! establishment of protein localization to organelle relationship: part_of GO:0072665 ! protein localization to vacuole property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2011-02-14T02:56:29Z [Term] id: GO:0072685 name: Mre11 complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an Mre11 complex, a trimeric protein complex that possesses endonuclease activity and is involved in meiotic recombination, DNA repair and checkpoint signaling." [GOC:mah, PMID:19211838] synonym: "MRN complex assembly" EXACT [GOC:mah] synonym: "MRX complex assembly" EXACT [GOC:mah] synonym: "Rad50 complex assembly" EXACT [GOC:mah] synonym: "RAD50-MRE11-NBN complex assembly" EXACT [CORUM:2767, GOC:mah] synonym: "Rad50-Rad32-Nbs1 complex assembly" EXACT [GOC:mah] synonym: "RMX complex assembly" EXACT [GOC:mah] is_a: GO:0043623 ! cellular protein complex assembly property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2011-05-12T02:52:06Z [Term] id: GO:0072686 name: mitotic spindle namespace: cellular_component def: "A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178] is_a: GO:0005819 ! spindle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2011-07-08T05:08:16Z [Term] id: GO:0072687 name: meiotic spindle namespace: cellular_component def: "A spindle that forms as part of meiosis. Several proteins, such as budding yeast Spo21p, fission yeast Spo2 and Spo13, and C. elegans mei-1, localize specifically to the meiotic spindle and are absent from the mitotic spindle." [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178] is_a: GO:0005819 ! spindle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2011-07-08T05:17:08Z [Term] id: GO:0072689 name: MCM complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an MCM complex, a hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:mah, PMID:21813639] is_a: GO:0043623 ! cellular protein complex assembly property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2011-08-12T10:57:29Z [Term] id: GO:0072690 name: single-celled organism vegetative growth phase namespace: biological_process def: "A phase of population growth during which single celled organisms reproduce by budding, fission, or other asexual methods." [GOC:mah, GOV:vw] subset: gocheck_do_not_annotate synonym: "vegetative growth of a single-celled organism" EXACT [] is_a: GO:0044848 ! biological phase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2011-08-19T12:05:19Z [Term] id: GO:0072691 name: initiation of premeiotic DNA replication namespace: biological_process def: "A process of DNA-dependent DNA replication initiation that occurs as part of premeiotic DNA replication." [GOC:mah, PMID:10888871] synonym: "initiation of meiotic DNA synthesis" RELATED [GOC:mah] synonym: "initiation of premeiotic DNA synthesis" RELATED [GOC:mah] synonym: "meiotic DNA replication initiation" RELATED [GOC:mah] synonym: "premeiotic DNA replication initiation" EXACT [GOC:mah] is_a: GO:1902974 ! meiotic DNA replication initiation intersection_of: GO:0006270 ! DNA replication initiation intersection_of: part_of GO:0006279 ! premeiotic DNA replication relationship: part_of GO:0006279 ! premeiotic DNA replication property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2011-08-19T03:16:20Z [Term] id: GO:0072692 name: chromatin silencing at centromere central core namespace: biological_process def: "Repression of transcription of DNA at the central core of a regional centromere by altering the structure of chromatin." [GOC:mah] synonym: "centromere central core chromatin silencing" EXACT [GOC:mah] synonym: "chromatin silencing at centromeric central core" EXACT [GOC:vw] synonym: "chromatin silencing at chromosome kinetochore domain" EXACT [GOC:vw] synonym: "heterochromatic silencing at centromere central core" EXACT [GOC:mah] is_a: GO:0030702 ! chromatin silencing at centromere property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2011-09-12T03:16:41Z [Term] id: GO:0072697 name: protein localization to cell cortex namespace: biological_process def: "A process in which a protein is transported to, or maintained in, the cell cortex." [GOC:mah] synonym: "protein localisation to cell cortex" EXACT [GOC:mah] is_a: GO:1990778 ! protein localization to cell periphery property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2012-04-11T01:16:33Z [Term] id: GO:0072698 name: protein localization to microtubule cytoskeleton namespace: biological_process def: "A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton." [GOC:mah] synonym: "protein localisation to microtubule cytoskeleton" EXACT [GOC:mah] is_a: GO:0044380 ! protein localization to cytoskeleton property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2012-04-11T01:19:35Z [Term] id: GO:0072699 name: protein localization to cortical microtubule cytoskeleton namespace: biological_process def: "A process in which a protein is transported to, or maintained at, a location within the cortical microtubule cytoskeleton." [GOC:mah] synonym: "protein localisation to cortical microtubule cytoskeleton" EXACT [GOC:mah] is_a: GO:0072697 ! protein localization to cell cortex is_a: GO:0072698 ! protein localization to microtubule cytoskeleton property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2012-04-11T01:23:36Z [Term] id: GO:0072702 name: response to methyl methanesulfonate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methyl methanesulfonate (MMS) stimulus." [CHEBI:25255, GOC:mah] synonym: "response to MMS" EXACT [CHEBI:25255, GOC:mah] is_a: GO:0010033 ! response to organic substance is_a: GO:1901700 ! response to oxygen-containing compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2012-04-11T03:04:12Z [Term] id: GO:0072703 name: cellular response to methyl methanesulfonate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methyl methanesulfonate (MMS) stimulus." [CHEBI:25255, GOC:mah] synonym: "cellular response to MMS" EXACT [CHEBI:25255, GOC:mah] is_a: GO:0071310 ! cellular response to organic substance is_a: GO:0072702 ! response to methyl methanesulfonate is_a: GO:1901701 ! cellular response to oxygen-containing compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2012-04-11T03:04:18Z [Term] id: GO:0072708 name: response to sorbitol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sorbitol stimulus." [CHEBI:30911, GOC:mah] synonym: "response to glucitol" EXACT [CHEBI:30911, GOC:mah] is_a: GO:0009743 ! response to carbohydrate property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2012-04-11T03:40:57Z [Term] id: GO:0072709 name: cellular response to sorbitol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sorbitol stimulus." [CHEBI:30911, GOC:mah] synonym: "cellular response to glucitol" EXACT [CHEBI:30911, GOC:mah] is_a: GO:0071322 ! cellular response to carbohydrate stimulus is_a: GO:0072708 ! response to sorbitol property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2012-04-11T03:41:03Z [Term] id: GO:0072710 name: response to hydroxyurea namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus." [CHEBI:44423, GOC:mah] synonym: "response to HU" EXACT [GOC:mah] is_a: GO:0010033 ! response to organic substance is_a: GO:1901698 ! response to nitrogen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2012-04-11T04:15:42Z [Term] id: GO:0072711 name: cellular response to hydroxyurea namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus." [CHEBI:44423, GOC:mah] synonym: "cellular response to HU" EXACT [GOC:mah] is_a: GO:0071241 ! cellular response to inorganic substance is_a: GO:0072710 ! response to hydroxyurea is_a: GO:1901699 ! cellular response to nitrogen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2012-04-11T04:15:56Z [Term] id: GO:0072712 name: response to thiabendazole namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thiabendazole stimulus." [CHEBI:45979, GOC:mah] synonym: "response to TBZ" EXACT [CHEBI:45979, GOC:mah] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2012-04-11T04:23:56Z [Term] id: GO:0072713 name: cellular response to thiabendazole namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thiabendazole stimulus." [CHEBI:45979, GOC:mah] synonym: "cellular response to TBZ" EXACT [CHEBI:45979, GOC:mah] is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:0072712 ! response to thiabendazole property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2012-04-11T04:24:19Z [Term] id: GO:0072714 name: response to selenite ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a selenite ion stimulus." [CHEBI:18212, GOC:mah] is_a: GO:0010035 ! response to inorganic substance property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2012-04-19T02:46:28Z [Term] id: GO:0072715 name: cellular response to selenite ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a selenite ion stimulus." [CHEBI:18212, GOC:mah] is_a: GO:0071241 ! cellular response to inorganic substance is_a: GO:0072714 ! response to selenite ion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2012-04-19T02:47:50Z [Term] id: GO:0072732 name: cellular response to calcium ion starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of calcium ions." [GOC:mah] synonym: "cellular response to calcium starvation" EXACT [GOC:mah] is_a: GO:0009267 ! cellular response to starvation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2012-07-06T02:42:26Z [Term] id: GO:0072741 name: protein localization to cell division site namespace: biological_process def: "A cellular protein localization process in which a protein is transported to, or maintained at, the site of cell division." [GOC:mah, PMID:19756689] synonym: "protein localisation to cell division site" EXACT [GOC:mah] is_a: GO:0034613 ! cellular protein localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2012-08-16T11:51:48Z [Term] id: GO:0072742 name: SAGA complex localization to transcription regulatory region namespace: biological_process def: "Any process in which a SAGA complex is transported to, or maintained in, a specific location in the transcription regulatory region of a gene." [GOC:mah] synonym: "SAGA complex localization to promoter" EXACT [GOC:mah] synonym: "SAGA complex recruitment" EXACT [GOC:mah] is_a: GO:0034629 ! cellular protein complex localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2012-08-24T10:36:03Z [Term] id: GO:0072752 name: cellular response to rapamycin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rapamycin stimulus." [GOC:TermGenie] is_a: GO:0071362 ! cellular response to ether is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:0071417 ! cellular response to organonitrogen compound is_a: GO:0097306 ! cellular response to alcohol is_a: GO:1901355 ! response to rapamycin is_a: GO:1901655 ! cellular response to ketone property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2012-09-14T11:13:34Z [Term] id: GO:0072754 name: cellular response to purvalanol A namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purvalanol A stimulus." [GOC:mah] is_a: GO:0071415 ! cellular response to purine-containing compound is_a: GO:1901560 ! response to purvalanol A property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2012-11-07T12:05:57Z [Term] id: GO:0072757 name: cellular response to camptothecin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus." [GOC:mah] synonym: "cellular response to CPT" EXACT [GOC:mah] is_a: GO:0071312 ! cellular response to alkaloid is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901563 ! response to camptothecin is_a: GO:1901701 ! cellular response to oxygen-containing compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2012-11-07T12:12:35Z [Term] id: GO:0072765 name: centromere localization namespace: biological_process def: "A cellular localization process in which a centromere/kinetochore is transported to, or maintained in, a specific location." [GOC:mah] synonym: "establishment and maintenance of kinetochore localization" EXACT [GOC:mah] synonym: "kinetochore localisation" EXACT [GOC:mah] synonym: "kinetochore localization" EXACT [] is_a: GO:0034629 ! cellular protein complex localization is_a: GO:0051640 ! organelle localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2012-11-21T13:30:53Z [Term] id: GO:0072766 name: centromere clustering at the nuclear envelope namespace: biological_process def: "A cellular localization process in which kinetochores/centromeres are coupled together at the nuclear periphery. This process is responsible for the Rabl-like configuration of chromosomes in the interphase nuclei. In fission yeast this occurs at a location near the old mitotic spindle pole body." [GOC:mah, GOC:vw, PMID:21965289, PMID:23166349] synonym: "centromere clustering at the nuclear periphery" EXACT [] synonym: "centromere-SPB clustering" RELATED [GOC:vw, PMID:18158900] synonym: "kinetochore clustering at SPB" RELATED [GOC:mah] synonym: "kinetochore clustering at spindle pole body" RELATED [] synonym: "kinetochore clustering at the old mitotic spindle pole body" RELATED [] synonym: "kinetochore localization at spindle pole body" RELATED [GOC:pr] synonym: "rabl configuration" RELATED [PMID:17881496] is_a: GO:0098653 ! centromere clustering relationship: part_of GO:0007059 ! chromosome segregation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2012-11-21T13:32:22Z [Term] id: GO:0075259 name: spore-bearing organ development namespace: biological_process def: "The process whose specific outcome is the progression of a spore-bearing organ over time, from its formation to the mature structure. A spore-bearing organ is an anatomical structure that produces new spores." [GOC:mah, GOC:mcc, GOC:pamgo_curators] synonym: "fruiting structure development" EXACT [] is_a: GO:0048513 ! organ development is_a: GO:0048608 ! reproductive structure development property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0075317 name: ascus development namespace: biological_process def: "The process that leads to the development of ascus, a sac-like structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed." [GOC:di, GOC:mah, GOC:mcc, GOC:pamgo_curators] comment: Note that ascospores and asci are separate biological structures. The ascus is the structure that contain the ascospores, but the development of the ascus is a different process than the formation of the ascospores themselves; for instance, some mutations affect sporulation without affecting ascus development. For this reason, GO:0030437 ascospore formation and GO:0075317 ascus development are different terms and are not linked. is_a: GO:0075259 ! spore-bearing organ development property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0080090 name: regulation of primary metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [PMID:19211694] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0044238 ! primary metabolic process relationship: regulates GO:0044238 ! primary metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: donghui creation_date: 2009-04-22T04:30:52Z [Term] id: GO:0080182 name: histone H3-K4 trimethylation namespace: biological_process def: "The modification of histone H3 by addition of three methyl groups to lysine at position 4 of the histone." [GOC:BHF, GOC:se, GOC:tb] is_a: GO:0018023 ! peptidyl-lysine trimethylation is_a: GO:0051568 ! histone H3-K4 methylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: donghui creation_date: 2011-08-10T04:18:36Z [Term] id: GO:0090001 name: replication fork arrest at tRNA locus namespace: biological_process def: "A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic tRNA transcription unit." [GOC:dph, GOC:tb] is_a: GO:0043111 ! replication fork arrest property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2009-06-24T11:36:15Z [Term] id: GO:0090068 name: positive regulation of cell cycle process namespace: biological_process def: "Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0045787 ! positive regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0022402 ! cell cycle process relationship: positively_regulates GO:0022402 ! cell cycle process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2009-09-09T11:39:52Z [Term] id: GO:0090148 name: membrane fission namespace: biological_process def: "A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0044802 ! single-organism membrane organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2009-12-08T03:06:36Z [Term] id: GO:0090150 name: establishment of protein localization to membrane namespace: biological_process def: "The directed movement of a protein to a specific location in a membrane." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "establishment of protein localisation in membrane" EXACT [GOC:mah] synonym: "establishment of protein localization in membrane" EXACT [GOC:curators] is_a: GO:0045184 ! establishment of protein localization relationship: part_of GO:0072657 ! protein localization to membrane property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2009-12-08T03:18:51Z [Term] id: GO:0090172 name: microtubule cytoskeleton organization involved in homologous chromosome segregation namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins that contributes to chromosomal pairing and precedes synapsis." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "microtubule cytoskeleton organisation involved in homologous chromosome segregation" EXACT [GOC:mah] synonym: "microtubule organization involved in chromosome pairing" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:0000226 ! microtubule cytoskeleton organization intersection_of: part_of GO:0045143 ! homologous chromosome segregation relationship: part_of GO:0045143 ! homologous chromosome segregation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2009-12-11T11:07:42Z [Term] id: GO:0090220 name: chromosome localization to nuclear envelope involved in homologous chromosome segregation namespace: biological_process def: "The directed movement of a chromosome to the nuclear envelope that contributes to homologous chromosome segregation and precedes synapsis." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:19913287] synonym: "chromosome localisation to nuclear envelope involved in homologous chromosome segregation" EXACT [GOC:mah] is_a: GO:0051303 ! establishment of chromosome localization relationship: part_of GO:0045143 ! homologous chromosome segregation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2010-01-13T10:20:33Z [Term] id: GO:0090231 name: regulation of spindle checkpoint namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb] comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc). subset: gocheck_do_not_manually_annotate is_a: GO:1901976 ! regulation of cell cycle checkpoint intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0031577 ! spindle checkpoint relationship: regulates GO:0031577 ! spindle checkpoint property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2010-01-20T10:29:43Z [Term] id: GO:0090232 name: positive regulation of spindle checkpoint namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle." [GOC:ascb_2009, GOC:dph, GOC:tb] subset: gocheck_do_not_manually_annotate synonym: "spindle checkpoint activation" NARROW [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090231 ! regulation of spindle checkpoint is_a: GO:1901978 ! positive regulation of cell cycle checkpoint intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0031577 ! spindle checkpoint relationship: positively_regulates GO:0031577 ! spindle checkpoint property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2010-01-20T10:29:43Z [Term] id: GO:0090266 name: regulation of mitotic cell cycle spindle assembly checkpoint namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mtg_cell_cycle] is_a: GO:1903504 ! regulation of mitotic spindle checkpoint intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007094 ! mitotic spindle assembly checkpoint relationship: regulates GO:0007094 ! mitotic spindle assembly checkpoint property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2010-02-05T02:06:37Z [Term] id: GO:0090267 name: positive regulation of mitotic cell cycle spindle assembly checkpoint namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mah, GOC:vw] is_a: GO:0045931 ! positive regulation of mitotic cell cycle is_a: GO:0090232 ! positive regulation of spindle checkpoint is_a: GO:0090266 ! regulation of mitotic cell cycle spindle assembly checkpoint intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007094 ! mitotic spindle assembly checkpoint relationship: positively_regulates GO:0007094 ! mitotic spindle assembly checkpoint property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2010-02-05T02:09:44Z [Term] id: GO:0090268 name: activation of mitotic cell cycle spindle assembly checkpoint namespace: biological_process def: "Any process that starts the inactive process of a mitotic cell cycle spindle assembly checkpoint." [GOC:mah, GOC:vw] is_a: GO:0090267 ! positive regulation of mitotic cell cycle spindle assembly checkpoint property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2010-02-05T02:09:44Z [Term] id: GO:0090302 name: APC-Cdc20 complex activity namespace: molecular_function def: "A ubiquitin-protein ligase activity that increases the rate or extent of the metaphase to anaphase transition of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] synonym: "mitotic anaphase-promoting complex activity" RELATED [GOC:vw] synonym: "ubiquitin-protein ligase activity involved in positive regulation of mitotic metaphase/anaphase transition" EXACT [GOC:dph, GOC:mah, GOC:tb] is_a: GO:0061630 ! ubiquitin protein ligase activity intersection_of: GO:0061630 ! ubiquitin protein ligase activity intersection_of: part_of GO:0045842 ! positive regulation of mitotic metaphase/anaphase transition relationship: part_of GO:0045842 ! positive regulation of mitotic metaphase/anaphase transition property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2010-03-17T10:27:04Z [Term] id: GO:0090304 name: nucleic acid metabolic process namespace: biological_process def: "Any cellular metabolic process involving nucleic acids." [GOC:dph, GOC:tb] is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0043170 ! macromolecule metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2010-04-07T10:18:47Z [Term] id: GO:0090305 name: nucleic acid phosphodiester bond hydrolysis namespace: biological_process def: "The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb] synonym: "nucleic acid cleavage" EXACT [GOC:dph, GOC:tb] is_a: GO:0090304 ! nucleic acid metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2010-04-07T10:26:30Z [Term] id: GO:0090306 name: spindle assembly involved in meiosis namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of meiosis." [GOC:tb, GOC:vw] synonym: "meiotic spindle assembly" EXACT [GOC:vw] is_a: GO:0000212 ! meiotic spindle organization is_a: GO:0051225 ! spindle assembly intersection_of: GO:0051225 ! spindle assembly intersection_of: part_of GO:0007126 ! meiotic nuclear division relationship: part_of GO:0007126 ! meiotic nuclear division property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2010-04-09T11:21:56Z [Term] id: GO:0090307 name: mitotic spindle assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of mitosis." [GOC:tb, GOC:vw] synonym: "spindle assembly involved in mitosis" EXACT [] is_a: GO:0007052 ! mitotic spindle organization is_a: GO:0051225 ! spindle assembly is_a: GO:1902850 ! microtubule cytoskeleton organization involved in mitosis intersection_of: GO:0051225 ! spindle assembly intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0007067 ! mitotic nuclear division property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2010-04-09T11:31:28Z [Term] id: GO:0090329 name: regulation of DNA-dependent DNA replication namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of DNA-dependent DNA replication, the process in which new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:dph, GOC:tb] is_a: GO:0006275 ! regulation of DNA replication intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006261 ! DNA-dependent DNA replication relationship: regulates GO:0006261 ! DNA-dependent DNA replication property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2010-05-14T10:42:04Z [Term] id: GO:0090407 name: organophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [GOC:chem_mtg] is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:1901576 ! organic substance biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2011-02-26T02:22:41Z [Term] id: GO:0090432 name: myristoyl-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + myristic acid + CoA = AMP + diphosphate + myristoyl-CoA." [GOC:al, PMID:18071249] synonym: "myristoyl-CoA synthetase activity" EXACT [] is_a: GO:0004467 ! long-chain fatty acid-CoA ligase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2012-07-25T03:31:31Z [Term] id: GO:0090433 name: palmitoyl-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + palmitic acid + CoA = AMP + diphosphate + palmitoyl-CoA." [GOC:al, PMID:18071249] synonym: "palmitoyl-CoA synthetase activity" EXACT [] is_a: GO:0004467 ! long-chain fatty acid-CoA ligase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2012-07-25T03:31:31Z [Term] id: GO:0090434 name: oleoyl-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + oleic acid + CoA = AMP + diphosphate + oleoyl-CoA." [GOC:al, PMID:18071249] synonym: "oleoyl-CoA synthetase activity" EXACT [] is_a: GO:0004467 ! long-chain fatty acid-CoA ligase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2012-07-25T03:31:31Z [Term] id: GO:0090466 name: histidine import namespace: biological_process def: "The directed movement of histidine into a cell or organelle." [GOC:tb] is_a: GO:0015817 ! histidine transport is_a: GO:0043090 ! amino acid import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2012-09-24T14:28:58Z [Term] id: GO:0090467 name: arginine import namespace: biological_process def: "The directed movement of arginine into a cell or organelle." [GOC:tb] is_a: GO:0015809 ! arginine transport is_a: GO:0043090 ! amino acid import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2012-09-24T14:28:58Z [Term] id: GO:0090468 name: valine import namespace: biological_process def: "The directed movement of valine into a cell or organelle." [GOC:tb] is_a: GO:0015829 ! valine transport is_a: GO:0043090 ! amino acid import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2012-09-24T14:28:58Z [Term] id: GO:0090469 name: asparagine import namespace: biological_process def: "The directed movement of asparagine into a cell or organelle." [GOC:tb] is_a: GO:0006867 ! asparagine transport is_a: GO:0043090 ! amino acid import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2012-09-24T14:28:58Z [Term] id: GO:0090476 name: isoleucine import namespace: biological_process def: "The directed movement of isoleucine into a cell or organelle." [GOC:tb] is_a: GO:0015818 ! isoleucine transport is_a: GO:0043090 ! amino acid import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2012-10-01T11:10:51Z [Term] id: GO:0090477 name: L-isoleucine import namespace: biological_process def: "The directed movement of L-isoleucine, the L-enantiomer of isoleucine, into a cell or organelle." [GOC:mah] is_a: GO:0043092 ! L-amino acid import is_a: GO:0090476 ! isoleucine import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2012-10-01T11:10:51Z [Term] id: GO:0090478 name: serine import namespace: biological_process def: "The directed movement of serine into a cell or organelle." [GOC:tb] is_a: GO:0032329 ! serine transport is_a: GO:0043090 ! amino acid import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2012-10-01T11:10:51Z [Term] id: GO:0090479 name: L-serine import namespace: biological_process def: "The directed movement of L-serine, the L-enantiomer of serine, into a cell or organelle." [GOC:mah] is_a: GO:0015825 ! L-serine transport is_a: GO:0043092 ! L-amino acid import is_a: GO:0090478 ! serine import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2012-10-01T11:10:51Z [Term] id: GO:0090481 name: pyrimidine nucleotide-sugar transmembrane transport namespace: biological_process def: "The directed movement of pyrimidine nucleotide-sugars across a membrane. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:tb] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "pyrimidine nucleotide-sugar membrane transport" EXACT [] is_a: GO:0015781 ! pyrimidine nucleotide-sugar transport is_a: GO:0072531 ! pyrimidine-containing compound transmembrane transport is_a: GO:1901679 ! nucleotide transmembrane transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2012-10-01T16:43:54Z [Term] id: GO:0090501 name: RNA phosphodiester bond hydrolysis namespace: biological_process def: "The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis." [GOC:dph, GOC:tb] is_a: GO:0016070 ! RNA metabolic process is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2012-10-22T12:05:27Z [Term] id: GO:0090503 name: RNA phosphodiester bond hydrolysis, exonucleolytic namespace: biological_process def: "The chemical reactions and pathways involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides." [GOC:dph, GOC:tb] is_a: GO:0090501 ! RNA phosphodiester bond hydrolysis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2012-10-22T12:05:27Z [Term] id: GO:0090509 name: nickel cation import into cell namespace: biological_process def: "The directed movement of nickel cations from outside of a cell into the intracellular region of a cell.." [GOC:mah] is_a: GO:0035444 ! nickel cation transmembrane transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2012-11-16T16:12:53Z [Term] id: GO:0090529 name: cell septum assembly namespace: biological_process alt_id: GO:0090530 def: "The assembly and arrangement of a cellular component that is composed of peptidoglycan and often chitin in addition to other materials and usually forms perpendicular to the long axis of a cell or hypha. It grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." [GOC:mtg_cell_cycle] synonym: "cell septum assembly involved in cell cycle cytokinesis" EXACT [] is_a: GO:0022607 ! cellular component assembly is_a: GO:0032506 ! cytokinetic process relationship: part_of GO:0000910 ! cytokinesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2013-02-06T10:26:38Z [Term] id: GO:0090599 name: alpha-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-linked alpha-D-glucose residue with release of alpha-D-glucose." [GOC:tb] is_a: GO:0015926 ! glucosidase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2014-08-22T14:33:31Z [Term] id: GO:0090646 name: mitochondrial tRNA processing namespace: biological_process def: "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group, in the mitochondrion." [GOC:vw] is_a: GO:0000963 ! mitochondrial RNA processing is_a: GO:0008033 ! tRNA processing property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2015-06-12T15:57:13Z [Term] id: GO:0097035 name: regulation of membrane lipid distribution namespace: biological_process def: "Any process that modulates the proportions or spatial arrangement of lipids in a cellular membrane." [GOC:mah, PMID:18441123, PMID:20823909] is_a: GO:0044802 ! single-organism membrane organization is_a: GO:0065008 ! regulation of biological quality property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2011-04-08T02:01:19Z [Term] id: GO:0097036 name: regulation of plasma membrane sterol distribution namespace: biological_process def: "Any process that modulates the proportions or spatial arrangement of sterols in the plasma membrane." [CHEBI:15889, GOC:mah, PMID:18441123, PMID:20823909] is_a: GO:0007009 ! plasma membrane organization is_a: GO:0097035 ! regulation of membrane lipid distribution property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2011-04-08T02:08:08Z [Term] id: GO:0097043 name: histone H3-K56 acetylation namespace: biological_process def: "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 56 of the histone." [GOC:bf, GOC:pr] is_a: GO:0043966 ! histone H3 acetylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2011-04-19T05:18:29Z [Term] id: GO:0097159 name: organic cyclic compound binding namespace: molecular_function def: "Interacting selectively and non-covalently with an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure." [CHEBI:33832, GOC:sjw, PMID:7583672] is_a: GO:0005488 ! binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2011-09-23T02:31:01Z [Term] id: GO:0097238 name: cellular response to methylglyoxal namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. Methylglyoxal is a 2-oxoaldehyde derived from propanal." [GOC:pr] is_a: GO:0051595 ! response to methylglyoxal is_a: GO:0071310 ! cellular response to organic substance is_a: GO:1901655 ! cellular response to ketone property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2012-02-02T12:26:35Z [Term] id: GO:0097286 name: iron ion import namespace: biological_process def: "The directed movement of iron ions into a cell or organelle." [GOC:mah, PMID:18622392] is_a: GO:0006826 ! iron ion transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2012-04-18T03:33:45Z [Term] id: GO:0097305 name: response to alcohol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus." [CHEBI:30879, GOC:pr] is_a: GO:0010033 ! response to organic substance is_a: GO:1901700 ! response to oxygen-containing compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2012-05-15T03:48:45Z [Term] id: GO:0097306 name: cellular response to alcohol namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus." [CHEBI:30879, GOC:pr] is_a: GO:0071310 ! cellular response to organic substance is_a: GO:0097305 ! response to alcohol is_a: GO:1901701 ! cellular response to oxygen-containing compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2012-05-15T03:49:51Z [Term] id: GO:0097319 name: carbohydrate import into cell namespace: biological_process def: "The directed movement of carbohydrate from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:al] is_a: GO:0008643 ! carbohydrate transport is_a: GO:0098657 ! import into cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2012-05-31T02:45:02Z [Term] id: GO:0097355 name: protein localization to heterochromatin namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into heterochromatin." [GOC:mah] synonym: "protein localisation to heterochromatin" EXACT [GOC:mah] is_a: GO:0071168 ! protein localization to chromatin property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2012-07-03T03:19:07Z [Term] id: GO:0097357 name: myo-inositol import into cell namespace: biological_process def: "The directed movement of myo-inositol from outside of a cell into the intracellular region of a cell." [GOC:mah] is_a: GO:0015798 ! myo-inositol transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2012-07-03T06:22:05Z [Term] id: GO:0097367 name: carbohydrate derivative binding namespace: molecular_function def: "Interacting selectively and non-covalently with a carbohydrate derivative." [GOC:pr] is_a: GO:0005488 ! binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2012-08-02T13:03:39Z [Term] id: GO:0097369 name: sodium ion import namespace: biological_process def: "The directed movement of sodium ions into a cell or organelle." [GOC:BHF] synonym: "sodium import" EXACT [] is_a: GO:0035725 ! sodium ion transmembrane transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2012-08-03T16:55:52Z [Term] id: GO:0097373 name: MCM core complex namespace: cellular_component def: "A protein complex that contains Mcm4, Mcm6, and Mcm7 proteins, and possesses DNA helicase activity. In the heterohexameric MCM complex, the Mcm4/6/7 proteins form a stable core, and Mcm2, Mcm3, and Mcm5 are more peripherally associated." [GOC:mah, PMID:10770926, PMID:15007098, PMID:9305914] synonym: "MCM4/6/7 complex" EXACT [] is_a: GO:0043234 ! protein complex property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2012-09-12T10:41:42Z [Term] id: GO:0097384 name: cellular lipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lipids, as carried out by individual cells." [GOC:pr] synonym: "cellular lipid anabolism" EXACT [] synonym: "cellular lipid biosynthesis" EXACT [] synonym: "cellular lipid formation" EXACT [] synonym: "cellular lipid synthesis" EXACT [] is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0044255 ! cellular lipid metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2012-10-16T16:47:09Z [Term] id: GO:0097404 name: succinate import into cell namespace: biological_process def: "The directed movement of succinate from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:al] is_a: GO:0015744 ! succinate transport is_a: GO:0098657 ! import into cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2012-10-29T11:17:44Z [Term] id: GO:0097405 name: malate import into cell namespace: biological_process def: "The directed movement of malate from outside of a cell into the intracellular region of a cell." [GOC:al] is_a: GO:0015743 ! malate transport is_a: GO:0098657 ! import into cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2012-10-29T11:18:48Z [Term] id: GO:0097406 name: malonic acid import into cell namespace: biological_process def: "The directed movement of malonic acid from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:al] synonym: "malonate import into cell" RELATED [] is_a: GO:0098657 ! import into cell is_a: GO:1900752 ! malonic acid transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2012-10-30T15:33:37Z [Term] id: GO:0097427 name: microtubule bundle namespace: cellular_component def: "An arrangement of closely apposed microtubules running parallel to each other." [NIF_Subcellular:sao1872343973] synonym: "microtubule fascicle" EXACT [] xref: NIF_Subcellular:sao1872343973 is_a: GO:0044430 ! cytoskeletal part relationship: has_part GO:0005874 ! microtubule property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2012-11-07T15:01:27Z [Term] id: GO:0097428 name: protein maturation by iron-sulfur cluster transfer namespace: biological_process def: "The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein." [GOC:al, GOC:mah, PMID:11939799, PMID:18322036, PMID:21977977] is_a: GO:0051604 ! protein maturation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2012-11-15T09:59:06Z [Term] id: GO:0097446 name: protein localization to eisosome filament namespace: biological_process def: "A process in which a protein is transported to, and/or maintained in, a specific location in a eisosome filament (also called linear eisosome), a filamentous cortical structure formed, in S. pombe, by the eisosome component Pil1." [GOC:mah, GOC:vw, PMID:22869600, PMID:23722945] synonym: "protein localization to linear eisosome" EXACT [] is_a: GO:0044380 ! protein localization to cytoskeleton is_a: GO:0072697 ! protein localization to cell cortex property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2012-12-17T09:37:49Z [Term] id: GO:0097459 name: iron ion import into cell namespace: biological_process def: "The directed movement of iron ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:mah, PMID:8321236] synonym: "iron import into cell" RELATED [GOC:mah] is_a: GO:0097286 ! iron ion import is_a: GO:0098659 ! inorganic cation import into cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2012-12-20T08:29:00Z [Term] id: GO:0097460 name: ferrous iron import into cell namespace: biological_process def: "The directed movement of ferrous iron (Fe(II) or Fe2+) ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:mah, PMID:8321236] synonym: "ferrous ion import into cell" EXACT [GOC:mah] is_a: GO:0070627 ! ferrous iron import is_a: GO:0097459 ! iron ion import into cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2012-12-20T08:31:05Z [Term] id: GO:0097461 name: ferric iron import into cell namespace: biological_process def: "The directed movement of ferric iron (Fe(III) or Fe3+) ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:mah, PMID:8321236] synonym: "ferric ion import into cell" EXACT [GOC:mah] is_a: GO:0033216 ! ferric iron import is_a: GO:0097459 ! iron ion import into cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2012-12-20T08:33:03Z [Term] id: GO:0097466 name: glycoprotein ERAD pathway namespace: biological_process def: "An ERAD pathway whereby endoplasmic reticulum (ER)-resident glycoproteins are targeted for degradation. Includes differential processing of the glycoprotein sugar chains, retrotranslocation to the cytosol and degradation by the ubiquitin-proteasome pathway. A glycoprotein is a compound in which a carbohydrate component is covalently bound to a protein component." [GOC:al, GOC:bf, PMID:16079177] synonym: "ER-associated glycoprotein degradation" EXACT [GOC:bf] synonym: "glycoprotein ERAD" EXACT [GOC:bf] synonym: "gpERAD" EXACT [PMID:25092655] synonym: "misfolded or incompletely synthesized glycoprotein catabolic process" BROAD [] is_a: GO:0006516 ! glycoprotein catabolic process is_a: GO:0036503 ! ERAD pathway is_a: GO:1901700 ! response to oxygen-containing compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2013-02-05T16:37:13Z [Term] id: GO:0097472 name: cyclin-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:pr] is_a: GO:0004672 ! protein kinase activity relationship: has_part GO:0030332 ! cyclin binding relationship: part_of GO:0051726 ! regulation of cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2013-03-06T13:46:04Z [Term] id: GO:0097506 name: deaminated base DNA N-glycosylase activity namespace: molecular_function def: "DNA N-glycosylase activity acting on deaminated bases." [GOC:al, PMID:18789404] synonym: "deaminated base DNA glycosylase activity" EXACT [] synonym: "DNA glycosylase activity acting on deaminated bases" EXACT [] is_a: GO:0019104 ! DNA N-glycosylase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2013-09-26T16:00:40Z [Term] id: GO:0097507 name: hypoxanthine DNA N-glycosylase activity namespace: molecular_function def: "DNA N-glycosylase activity acting on deaminated adenine (hypoxanthine)." [GOC:al, PMID:18789404] synonym: "hypoxanthine-DNA glycosylase activity" RELATED [] is_a: GO:0097506 ! deaminated base DNA N-glycosylase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2013-09-26T16:02:08Z [Term] id: GO:0097508 name: xanthine DNA N-glycosylase activity namespace: molecular_function def: "DNA N-glycosylase activity acting on deaminated guanine (xanthine)." [GOC:al, PMID:18789404] synonym: "xanthine-DNA glycosylase activity" RELATED [] is_a: GO:0097506 ! deaminated base DNA N-glycosylase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2013-09-26T16:03:10Z [Term] id: GO:0097509 name: oxanine DNA N-glycosylase activity namespace: molecular_function def: "DNA N-glycosylase activity acting on deaminated guanine where the resulting base (oxanine) is generated by NO- or HNO2-induced nitrosative deamination." [GOC:al, PMID:18789404] synonym: "oxanine-DNA glycosylase activity" RELATED [] is_a: GO:0097506 ! deaminated base DNA N-glycosylase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2013-09-26T16:03:58Z [Term] id: GO:0097525 name: spliceosomal snRNP complex namespace: cellular_component def: "A ribonucleoprotein complex involved in formation of the spliceosome and composed of one or more snRNA and multiple protein components." [GOC:pr, ISBN:0879695897] is_a: GO:0030532 ! small nuclear ribonucleoprotein complex property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2013-10-18T15:57:45Z [Term] id: GO:0097549 name: chromatin organization involved in negative regulation of transcription namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription by chromatin organization." [GOC:di, PMID:23123093] subset: gocheck_do_not_manually_annotate synonym: "negative regulation of transcription by chromatin organization" EXACT [] is_a: GO:0034401 ! chromatin organization involved in regulation of transcription intersection_of: GO:0006325 ! chromatin organization intersection_of: part_of GO:0045892 ! negative regulation of transcription, DNA-templated relationship: part_of GO:0045892 ! negative regulation of transcription, DNA-templated property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2014-01-22T08:20:50Z [Term] id: GO:0097574 name: lateral part of cell namespace: cellular_component def: "The region of a polarized cell other than its tips or ends (in some cell types, one end may be called the apex and the other the base). For example, in a polarized epithelial cell, the lateral part includes the cell sides which interface adjacent cells." [GOC:pr] is_a: GO:0044464 ! cell part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2014-02-26T13:27:27Z [Term] id: GO:0097575 name: lateral cell cortex namespace: cellular_component def: "The region directly beneath the plasma membrane of the lateral portion of the cell." [GOC:mah, PMID:24146635] is_a: GO:0099738 ! cell cortex region intersection_of: GO:0099738 ! cell cortex region intersection_of: part_of GO:0097574 ! lateral part of cell relationship: part_of GO:0097574 ! lateral part of cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2014-02-26T13:29:22Z [Term] id: GO:0097576 name: vacuole fusion namespace: biological_process def: "Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole." [GOC:pr, GOC:vw, http://en.wikipedia.org/wiki/Vacuole] is_a: GO:0007033 ! vacuole organization is_a: GO:0048284 ! organelle fusion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2014-02-28T09:49:31Z [Term] id: GO:0097617 name: annealing activity namespace: molecular_function def: "A nucleic acid binding activity that brings together complementary sequences of nucleic acids so that they pair by hydrogen bonds to form a double-stranded polynucleotide." [GOC:mba, http://en.wikipedia.org/wiki/Nucleic_acid_thermodynamics#Annealing] comment: The term 'annealing' is often used to describe the binding of a DNA probe, or the binding of a primer to a DNA strand during a polymerase chain reaction. The term is also often used to describe the reformation (renaturation) of complementary strands that were separated by heat (thermally denatured). For example, proteins such as RAD52 can help DNA anneal. If at all possible, please annotate to the more specific terms GO:0036310 'annealing helicase activity', GO:0097098 'DNA/RNA hybrid annealing activity' or GO:0033592 'RNA strand annealing activity'. synonym: "renaturation" RELATED [] is_a: GO:0003676 ! nucleic acid binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2014-06-13T10:18:43Z [Term] id: GO:0097659 name: nucleic acid-templated transcription namespace: biological_process def: "The cellular synthesis of RNA on a template of nucleic acid (DNA or RNA)." [GOC:pr, GOC:txnOH, GOC:vw] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0032774 ! RNA biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: paola creation_date: 2014-10-01T13:49:27Z [Term] id: GO:0098501 name: polynucleotide dephosphorylation namespace: biological_process def: "The process of removing one or more phosphate groups from a polynucleotide." [GOC:DOS] is_a: GO:0006139 ! nucleobase-containing compound metabolic process is_a: GO:0016311 ! dephosphorylation is_a: GO:0043170 ! macromolecule metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: davidos creation_date: 2013-09-18T14:49:10Z [Term] id: GO:0098506 name: polynucleotide 3' dephosphorylation namespace: biological_process def: "The process of removing one or more phosphate groups from the 3' end of a polynucleotide." [GOC:dos] is_a: GO:0098501 ! polynucleotide dephosphorylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0098507 name: polynucleotide 5' dephosphorylation namespace: biological_process def: "The process of removing one or more phosphate groups from the 5' end of a polynucleotide." [GOC:dos] is_a: GO:0098501 ! polynucleotide dephosphorylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0098518 name: polynucleotide phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphopolynucleotide + H2O = polynucleotide + phosphate." [GOC:mah] is_a: GO:0016791 ! phosphatase activity relationship: part_of GO:0098501 ! polynucleotide dephosphorylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: davidos creation_date: 2013-09-26T11:02:35Z [Term] id: GO:0098588 name: bounding membrane of organelle namespace: cellular_component def: "The lipid bilayer that forms the outer-most layer of an organelle." [GOC:dos] comment: Examples include the outer membranes of double membrane bound organelles such as mitochondria as well as the bounding membranes of single-membrane bound organelles such as lysosomes. is_a: GO:0031090 ! organelle membrane property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: davidos creation_date: 2014-02-26T13:41:31Z [Term] id: GO:0098609 name: cell-cell adhesion namespace: biological_process def: "The attachment of one cell to another cell via adhesion molecules." [GOC:dos] is_a: GO:0007155 ! cell adhesion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: davidos creation_date: 2014-04-16T13:40:03Z [Term] id: GO:0098610 name: adhesion between unicellular organisms namespace: biological_process def: "The attachment of two unicellular organisms to each other." [GOC:dos] synonym: "multi-organismal cell-cell adhesion" BROAD [] is_a: GO:0098609 ! cell-cell adhesion is_a: GO:0098740 ! multi organism cell adhesion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0098611 name: cell-cell adhesion involved in galactose-specific flocculation namespace: biological_process def: "Cell-cell adhesion between two single-celled organisms, during flocculation, mediated via the binding of cell wall proteins on one cell to galactose residues on the other." [GOC:dos, PMID:22098069] is_a: GO:0043690 ! cell-cell adhesion involved in flocculation via cell wall protein-carbohydrate interaction intersection_of: GO:0098741 ! adhesion between unicellular organisms via cell-wall interaction intersection_of: part_of GO:0036349 ! galactose-specific flocculation relationship: part_of GO:0036349 ! galactose-specific flocculation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0098612 name: cell-cell adhesion involved in mannose-specific flocculation namespace: biological_process def: "Cell-cell adhesion between two single-celled organisms, during flocculation, mediated via the binding of cell wall proteins on one cell to mannose residues on the other." [GOC:dos, PMID:22098069] is_a: GO:0043690 ! cell-cell adhesion involved in flocculation via cell wall protein-carbohydrate interaction intersection_of: GO:0098741 ! adhesion between unicellular organisms via cell-wall interaction intersection_of: part_of GO:0036350 ! mannose-specific flocculation relationship: part_of GO:0036350 ! mannose-specific flocculation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0098630 name: aggregation of unicellular organisms namespace: biological_process def: "The clustering together of unicellular organisms in suspension form aggregates." [GOC:dos] synonym: "aggregation of single cell organisms" EXACT [] is_a: GO:0044764 ! multi-organism cellular process is_a: GO:0098743 ! cell aggregation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0098653 name: centromere clustering namespace: biological_process alt_id: GO:0098587 def: "The process by which centromeres/kinetochores become localized to clusters. In Saccharomyces cerevisiae, kinetochores form a single cluster before metaphase and later in the cell cycle appear as two clusters." [GOC:di, GOC:dos, PMID:10761928, PMID:23283988, PMID:8486732] comment: As inner kinetochores are an integral part of centromeres, we treat centromere and kinetochore clustering as the same process. synonym: "kinetochore clustering" EXACT [] is_a: GO:0050000 ! chromosome localization is_a: GO:0072765 ! centromere localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: davidos creation_date: 2014-05-23T19:03:37Z [Term] id: GO:0098655 name: cation transmembrane transport namespace: biological_process def: "A process in which a cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:dos, GOC:vw] is_a: GO:0006812 ! cation transport is_a: GO:0034220 ! ion transmembrane transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0098656 name: anion transmembrane transport namespace: biological_process def: "A process in which an anion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:dos, GOC:vw] is_a: GO:0006820 ! anion transport is_a: GO:0034220 ! ion transmembrane transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0098657 name: import into cell namespace: biological_process def: "The directed movement of some substance from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos] synonym: "uptake" EXACT [] is_a: GO:0006810 ! transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0098659 name: inorganic cation import into cell namespace: biological_process def: "The directed movement of inorganic cations from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos] is_a: GO:0006812 ! cation transport is_a: GO:0099587 ! inorganic ion import into cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0098660 name: inorganic ion transmembrane transport namespace: biological_process def: "A process in which an inorganic ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "inorganic ion membrane transport" EXACT [] synonym: "transmembrane inorganic ion transport" EXACT [GOC:dph, GOC:tb] is_a: GO:0034220 ! ion transmembrane transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0098662 name: inorganic cation transmembrane transport namespace: biological_process def: "A process in which an inorganic cation is transported from one side of a membrane to the other by means of some agent such as a transporter or pore." [GOC:mah] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "inorganic cation membrane transport" EXACT [] synonym: "transmembrane inorganic cation transport" EXACT [GOC:dph, GOC:tb] is_a: GO:0098655 ! cation transmembrane transport is_a: GO:0098660 ! inorganic ion transmembrane transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0098687 name: chromosomal region namespace: cellular_component def: "Any subdivision of a chromosome along its length." [GOC:dos] comment: Chromosomal regions include parts that are not part of the chromatin. Examples include the kinetochore. synonym: "chromosome region" EXACT [] is_a: GO:0044427 ! chromosomal part property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0098732 name: macromolecule deacylation namespace: biological_process def: "The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a macromolecule." [GOC:dos] is_a: GO:0043412 ! macromolecule modification property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0098740 name: multi organism cell adhesion namespace: biological_process def: "Cell adhesion that involves cells from multiple organisms or that is mediated by gene products from multiple organisms." [GOC:dos] is_a: GO:0007155 ! cell adhesion is_a: GO:0051704 ! multi-organism process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0098741 name: adhesion between unicellular organisms via cell-wall interaction namespace: biological_process def: "The attachment of two unicellular organisms to each other via interaction between cell-wall components." [GOC:dos] is_a: GO:0098610 ! adhesion between unicellular organisms property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0098742 name: cell-cell adhesion via plasma-membrane adhesion molecules namespace: biological_process def: "The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the cell membrane." [GOC:dos] is_a: GO:0098609 ! cell-cell adhesion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0098743 name: cell aggregation namespace: biological_process def: "The clustering together and adhesion of initially separate cells to form an aggregate. Examples include the clustering of unicellular organisms or blood cells in suspension and the condensation of mesenchymal cells during cartilage formation." [GOC:dos] is_a: GO:0008150 ! biological_process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0098762 name: meiotic cell cycle phase namespace: biological_process def: "One of the distinct periods or stages into which the meiotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GOC:dos] comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0022403 ! cell cycle phase intersection_of: GO:0022403 ! cell cycle phase intersection_of: happens_during GO:0051321 ! meiotic cell cycle relationship: happens_during GO:0051321 ! meiotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0098763 name: mitotic cell cycle phase namespace: biological_process def: "One of the distinct periods or stages into which the mitotic cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GOC:dos] comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0022403 ! cell cycle phase intersection_of: GO:0022403 ! cell cycle phase intersection_of: happens_during GO:0000278 ! mitotic cell cycle relationship: happens_during GO:0000278 ! mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0098764 name: meiosis I cell cycle phase namespace: biological_process def: "A meiotic cell cycle phase prior to a during which some part of meiosis I nuclear division or the proceeding cytokinesis occurs." [GOC:dos] comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0098762 ! meiotic cell cycle phase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0098765 name: meiosis II cell cycle phase namespace: biological_process def: "A meiotic cell cycle phase that occurs after meiosis I (the first meiotic nuclear division)." [GOC:dos] comment: This term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation should be to 'regulation of x/y phase transition' or to a process which occurs during the reported phase (e.g. mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0098762 ! meiotic cell cycle phase property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0098772 name: molecular function regulator namespace: molecular_function def: "A molecular function that modulates the activity of a gene product or complex. Examples include enzyme regulators and channel regulators." [GOC:dos, GOC:pt] is_a: GO:0003674 ! molecular_function intersection_of: GO:0003674 ! molecular_function intersection_of: regulates GO:0003674 ! molecular_function relationship: regulates GO:0003674 ! molecular_function property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0098781 name: ncRNA transcription namespace: biological_process def: "The transcription of non (protein) coding RNA from a DNA template." [GOC:dos] is_a: GO:0006351 ! transcription, DNA-templated is_a: GO:0034660 ! ncRNA metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0098791 name: Golgi subcompartment namespace: cellular_component def: "A compartment that consists of a lumen and an enclosing membrane, and is part of the Golgi Apparatus." [GOC:dos] is_a: GO:0031984 ! organelle subcompartment is_a: GO:0044431 ! Golgi apparatus part intersection_of: GO:0031984 ! organelle subcompartment intersection_of: part_of GO:0005794 ! Golgi apparatus relationship: part_of GO:0005794 ! Golgi apparatus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0098796 name: membrane protein complex namespace: cellular_component def: "Any protein complex that is part of a membrane." [GOC:dos] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part intersection_of: GO:0043234 ! protein complex intersection_of: part_of GO:0016020 ! membrane relationship: part_of GO:0016020 ! membrane property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0098798 name: mitochondrial protein complex namespace: cellular_component def: "A protein complex that is part of a mitochondion." [GOC:dos] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0043234 ! protein complex is_a: GO:0044429 ! mitochondrial part intersection_of: GO:0043234 ! protein complex intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005739 ! mitochondrion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0098800 name: inner mitochondrial membrane protein complex namespace: cellular_component def: "Any protein complex that is part of the inner mitochondrial membrane." [GOC:dos] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0098796 ! membrane protein complex is_a: GO:0098798 ! mitochondrial protein complex intersection_of: GO:0043234 ! protein complex intersection_of: part_of GO:0005743 ! mitochondrial inner membrane relationship: part_of GO:0005743 ! mitochondrial inner membrane property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0098803 name: respiratory chain complex namespace: cellular_component def: "Any protein complex that is part of a respiratory chain" [GOC:dos] is_a: GO:0098796 ! membrane protein complex intersection_of: GO:0043234 ! protein complex intersection_of: part_of GO:0070469 ! respiratory chain relationship: part_of GO:0070469 ! respiratory chain property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0098813 name: nuclear chromosome segregation namespace: biological_process def: "The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:dos] is_a: GO:0007059 ! chromosome segregation is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007049 ! cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0099587 name: inorganic ion import into cell namespace: biological_process def: "The directed movement of inorganic ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:dos] is_a: GO:0006811 ! ion transport is_a: GO:0098657 ! import into cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:0099738 name: cell cortex region namespace: cellular_component def: "The complete extent of cell cortex that underlies some some region of the plamsma membrane" [GOC:dos] is_a: GO:0005938 ! cell cortex is_a: GO:0044448 ! cell cortex part intersection_of: GO:0005938 ! cell cortex intersection_of: part_of GO:0005938 ! cell cortex relationship: part_of GO:0005938 ! cell cortex property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Term] id: GO:1900087 name: positive regulation of G1/S transition of mitotic cell cycle namespace: biological_process def: "Any cell cycle regulatory process that promotes the commitment of a cell from G1 to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] synonym: "activation of G1/S transition of mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "up regulation of G1/S transition of mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "up-regulation of G1/S transition of mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "upregulation of G1/S transition of mitotic cell cycle" EXACT [GOC:TermGenie] is_a: GO:1901992 ! positive regulation of mitotic cell cycle phase transition is_a: GO:1902808 ! positive regulation of cell cycle G1/S phase transition is_a: GO:2000045 ! regulation of G1/S transition of mitotic cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0000082 ! G1/S transition of mitotic cell cycle relationship: positively_regulates GO:0000082 ! G1/S transition of mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rph creation_date: 2012-02-08T12:24:39Z [Term] id: GO:1900262 name: regulation of DNA-directed DNA polymerase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA-directed DNA polymerase activity." [GOC:TermGenie] synonym: "regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie] synonym: "regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie] synonym: "regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie] synonym: "regulation of DNA duplicase activity" EXACT [GOC:TermGenie] synonym: "regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "regulation of DNA polymerase alpha" NARROW [GOC:TermGenie] synonym: "regulation of DNA polymerase beta" NARROW [GOC:TermGenie] synonym: "regulation of DNA polymerase gamma" NARROW [GOC:TermGenie] synonym: "regulation of DNA polymerase I" NARROW [GOC:TermGenie] synonym: "regulation of DNA polymerase II" NARROW [GOC:TermGenie] synonym: "regulation of DNA polymerase III" NARROW [GOC:TermGenie] synonym: "regulation of DNA polymerase V activity" NARROW [GOC:TermGenie] synonym: "regulation of DNA replicase activity" EXACT [GOC:TermGenie] synonym: "regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie] synonym: "regulation of duplicase" BROAD [GOC:TermGenie] synonym: "regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "regulation of Klenow fragment" NARROW [GOC:TermGenie] synonym: "regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "regulation of sequenase" RELATED [GOC:TermGenie] synonym: "regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "regulation of Taq DNA polymerase" NARROW [GOC:TermGenie] synonym: "regulation of Taq Pol I" NARROW [GOC:TermGenie] synonym: "regulation of Tca DNA polymerase" NARROW [GOC:TermGenie] synonym: "regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie] is_a: GO:0051338 ! regulation of transferase activity is_a: GO:0090329 ! regulation of DNA-dependent DNA replication is_a: GO:2000278 ! regulation of DNA biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0003887 ! DNA-directed DNA polymerase activity relationship: regulates GO:0003887 ! DNA-directed DNA polymerase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tb creation_date: 2012-04-03T11:07:08Z [Term] id: GO:1900264 name: positive regulation of DNA-directed DNA polymerase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA-directed DNA polymerase activity." [GOC:TermGenie] synonym: "activation of alpha DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of beta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of delta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "activation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie] synonym: "activation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie] synonym: "activation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie] synonym: "activation of DNA duplicase activity" EXACT [GOC:TermGenie] synonym: "activation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "activation of DNA polymerase alpha" NARROW [GOC:TermGenie] synonym: "activation of DNA polymerase beta" NARROW [GOC:TermGenie] synonym: "activation of DNA polymerase gamma" NARROW [GOC:TermGenie] synonym: "activation of DNA polymerase I" NARROW [GOC:TermGenie] synonym: "activation of DNA polymerase II" NARROW [GOC:TermGenie] synonym: "activation of DNA polymerase III" NARROW [GOC:TermGenie] synonym: "activation of DNA polymerase V activity" NARROW [GOC:TermGenie] synonym: "activation of DNA replicase activity" EXACT [GOC:TermGenie] synonym: "activation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie] synonym: "activation of DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of duplicase" BROAD [GOC:TermGenie] synonym: "activation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of eta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of iota DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of kappa DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of Klenow fragment" NARROW [GOC:TermGenie] synonym: "activation of lambda DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of mu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of nu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of sequenase" RELATED [GOC:TermGenie] synonym: "activation of sigma DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of Taq DNA polymerase" NARROW [GOC:TermGenie] synonym: "activation of Taq Pol I" NARROW [GOC:TermGenie] synonym: "activation of Tca DNA polymerase" NARROW [GOC:TermGenie] synonym: "activation of theta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "activation of zeta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "positive regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie] synonym: "positive regulation of DNA duplicase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "positive regulation of DNA polymerase alpha" NARROW [GOC:TermGenie] synonym: "positive regulation of DNA polymerase beta" NARROW [GOC:TermGenie] synonym: "positive regulation of DNA polymerase gamma" NARROW [GOC:TermGenie] synonym: "positive regulation of DNA polymerase I" NARROW [GOC:TermGenie] synonym: "positive regulation of DNA polymerase II" NARROW [GOC:TermGenie] synonym: "positive regulation of DNA polymerase III" NARROW [GOC:TermGenie] synonym: "positive regulation of DNA polymerase V activity" NARROW [GOC:TermGenie] synonym: "positive regulation of DNA replicase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of duplicase" BROAD [GOC:TermGenie] synonym: "positive regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of Klenow fragment" NARROW [GOC:TermGenie] synonym: "positive regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of sequenase" RELATED [GOC:TermGenie] synonym: "positive regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of Taq DNA polymerase" NARROW [GOC:TermGenie] synonym: "positive regulation of Taq Pol I" NARROW [GOC:TermGenie] synonym: "positive regulation of Tca DNA polymerase" NARROW [GOC:TermGenie] synonym: "positive regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "up regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie] synonym: "up regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie] synonym: "up regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie] synonym: "up regulation of DNA duplicase activity" EXACT [GOC:TermGenie] synonym: "up regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "up regulation of DNA polymerase alpha" NARROW [GOC:TermGenie] synonym: "up regulation of DNA polymerase beta" NARROW [GOC:TermGenie] synonym: "up regulation of DNA polymerase gamma" NARROW [GOC:TermGenie] synonym: "up regulation of DNA polymerase I" NARROW [GOC:TermGenie] synonym: "up regulation of DNA polymerase II" NARROW [GOC:TermGenie] synonym: "up regulation of DNA polymerase III" NARROW [GOC:TermGenie] synonym: "up regulation of DNA polymerase V activity" NARROW [GOC:TermGenie] synonym: "up regulation of DNA replicase activity" EXACT [GOC:TermGenie] synonym: "up regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie] synonym: "up regulation of DNA-directed DNA polymerase activity" EXACT [GOC:TermGenie] synonym: "up regulation of duplicase" BROAD [GOC:TermGenie] synonym: "up regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up regulation of Klenow fragment" NARROW [GOC:TermGenie] synonym: "up regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up regulation of sequenase" RELATED [GOC:TermGenie] synonym: "up regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up regulation of Taq DNA polymerase" NARROW [GOC:TermGenie] synonym: "up regulation of Taq Pol I" NARROW [GOC:TermGenie] synonym: "up regulation of Tca DNA polymerase" NARROW [GOC:TermGenie] synonym: "up regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of beta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of delta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "up-regulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie] synonym: "up-regulation of DNA duplicase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA polymerase alpha" NARROW [GOC:TermGenie] synonym: "up-regulation of DNA polymerase beta" NARROW [GOC:TermGenie] synonym: "up-regulation of DNA polymerase gamma" NARROW [GOC:TermGenie] synonym: "up-regulation of DNA polymerase I" NARROW [GOC:TermGenie] synonym: "up-regulation of DNA polymerase II" NARROW [GOC:TermGenie] synonym: "up-regulation of DNA polymerase III" NARROW [GOC:TermGenie] synonym: "up-regulation of DNA polymerase V activity" NARROW [GOC:TermGenie] synonym: "up-regulation of DNA replicase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of DNA-directed DNA polymerase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of duplicase" BROAD [GOC:TermGenie] synonym: "up-regulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of eta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of iota DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of Klenow fragment" NARROW [GOC:TermGenie] synonym: "up-regulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of mu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of nu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of sequenase" RELATED [GOC:TermGenie] synonym: "up-regulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of Taq DNA polymerase" NARROW [GOC:TermGenie] synonym: "up-regulation of Taq Pol I" NARROW [GOC:TermGenie] synonym: "up-regulation of Tca DNA polymerase" NARROW [GOC:TermGenie] synonym: "up-regulation of theta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "up-regulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "upregulation of alpha DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "upregulation of beta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "upregulation of delta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "upregulation of deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "upregulation of deoxyribonucleic acid duplicase activity" EXACT [GOC:TermGenie] synonym: "upregulation of deoxyribonucleic duplicase activity" EXACT [GOC:TermGenie] synonym: "upregulation of deoxyribonucleic polymerase I" NARROW [GOC:TermGenie] synonym: "upregulation of DNA duplicase activity" EXACT [GOC:TermGenie] synonym: "upregulation of DNA nucleotidyltransferase (DNA-directed) activity" EXACT [GOC:TermGenie] synonym: "upregulation of DNA polymerase alpha" NARROW [GOC:TermGenie] synonym: "upregulation of DNA polymerase beta" NARROW [GOC:TermGenie] synonym: "upregulation of DNA polymerase gamma" NARROW [GOC:TermGenie] synonym: "upregulation of DNA polymerase I" NARROW [GOC:TermGenie] synonym: "upregulation of DNA polymerase II" NARROW [GOC:TermGenie] synonym: "upregulation of DNA polymerase III" NARROW [GOC:TermGenie] synonym: "upregulation of DNA polymerase V activity" NARROW [GOC:TermGenie] synonym: "upregulation of DNA replicase activity" EXACT [GOC:TermGenie] synonym: "upregulation of DNA-dependent DNA polymerase activity" EXACT [GOC:TermGenie] synonym: "upregulation of DNA-directed DNA polymerase activity" EXACT [GOC:TermGenie] synonym: "upregulation of duplicase" BROAD [GOC:TermGenie] synonym: "upregulation of epsilon DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "upregulation of eta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "upregulation of gamma DNA-directed DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "upregulation of iota DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "upregulation of kappa DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "upregulation of Klenow fragment" NARROW [GOC:TermGenie] synonym: "upregulation of lambda DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "upregulation of mu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "upregulation of nu DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "upregulation of sequenase" RELATED [GOC:TermGenie] synonym: "upregulation of sigma DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "upregulation of Taq DNA polymerase" NARROW [GOC:TermGenie] synonym: "upregulation of Taq Pol I" NARROW [GOC:TermGenie] synonym: "upregulation of Tca DNA polymerase" NARROW [GOC:TermGenie] synonym: "upregulation of theta DNA polymerase activity" NARROW [GOC:TermGenie] synonym: "upregulation of zeta DNA polymerase activity" NARROW [GOC:TermGenie] is_a: GO:0051347 ! positive regulation of transferase activity is_a: GO:1900262 ! regulation of DNA-directed DNA polymerase activity is_a: GO:2000573 ! positive regulation of DNA biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0003887 ! DNA-directed DNA polymerase activity relationship: positively_regulates GO:0003887 ! DNA-directed DNA polymerase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tb creation_date: 2012-04-03T11:07:27Z [Term] id: GO:1900752 name: malonic acid transport namespace: biological_process def: "The directed movement of a malonic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:TermGenie, PMID:9128730, PMID:9573154] synonym: "C3H4O4 transport" RELATED [GOC:TermGenie] synonym: "H2malo transport" RELATED [GOC:TermGenie] synonym: "HOOC-CH2-COOH transport" RELATED [GOC:TermGenie] synonym: "propanedioic acid transport" EXACT [GOC:TermGenie] is_a: GO:0006835 ! dicarboxylic acid transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2012-05-29T02:40:33Z [Term] id: GO:1901135 name: carbohydrate derivative metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carbohydrate derivative." [GOC:TermGenie] synonym: "carbohydrate derivative metabolism" EXACT [GOC:TermGenie] is_a: GO:0071704 ! organic substance metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: bf creation_date: 2012-07-12T04:05:09Z [Term] id: GO:1901136 name: carbohydrate derivative catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carbohydrate derivative." [GOC:TermGenie] synonym: "carbohydrate derivative breakdown" EXACT [GOC:TermGenie] synonym: "carbohydrate derivative catabolism" EXACT [GOC:TermGenie] synonym: "carbohydrate derivative degradation" EXACT [GOC:TermGenie] is_a: GO:1901135 ! carbohydrate derivative metabolic process is_a: GO:1901575 ! organic substance catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: bf creation_date: 2012-07-12T04:05:31Z [Term] id: GO:1901137 name: carbohydrate derivative biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carbohydrate derivative." [GOC:TermGenie] synonym: "carbohydrate derivative anabolism" EXACT [GOC:TermGenie] synonym: "carbohydrate derivative biosynthesis" EXACT [GOC:TermGenie] synonym: "carbohydrate derivative formation" EXACT [GOC:TermGenie] synonym: "carbohydrate derivative synthesis" EXACT [GOC:TermGenie] is_a: GO:1901135 ! carbohydrate derivative metabolic process is_a: GO:1901576 ! organic substance biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: bf creation_date: 2012-07-12T04:05:39Z [Term] id: GO:1901264 name: carbohydrate derivative transport namespace: biological_process def: "The directed movement of a carbohydrate derivative into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:bf, GOC:jl, GOC:TermGenie] is_a: GO:0044765 ! single-organism transport is_a: GO:0071702 ! organic substance transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: bf creation_date: 2012-08-16T14:51:22Z [Term] id: GO:1901265 name: nucleoside phosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with nucleoside phosphate." [GOC:TermGenie] is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: bf creation_date: 2012-08-17T12:59:58Z [Term] id: GO:1901293 name: nucleoside phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nucleoside phosphate." [GOC:TermGenie] synonym: "nucleoside phosphate anabolism" EXACT [GOC:TermGenie] synonym: "nucleoside phosphate biosynthesis" EXACT [GOC:TermGenie] synonym: "nucleoside phosphate formation" EXACT [GOC:TermGenie] synonym: "nucleoside phosphate synthesis" EXACT [GOC:TermGenie] is_a: GO:0006753 ! nucleoside phosphate metabolic process is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process is_a: GO:0044711 ! single-organism biosynthetic process is_a: GO:0090407 ! organophosphate biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: bf creation_date: 2012-08-20T12:33:45Z [Term] id: GO:1901355 name: response to rapamycin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rapamycin stimulus." [GOC:TermGenie] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0045472 ! response to ether is_a: GO:0097305 ! response to alcohol is_a: GO:1901654 ! response to ketone property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2012-09-13T13:12:26Z [Term] id: GO:1901360 name: organic cyclic compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic cyclic compound." [GOC:TermGenie] synonym: "organic cyclic compound metabolism" EXACT [GOC:TermGenie] is_a: GO:0071704 ! organic substance metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: bf creation_date: 2012-09-14T09:03:51Z [Term] id: GO:1901361 name: organic cyclic compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of organic cyclic compound." [GOC:TermGenie] synonym: "organic cyclic compound breakdown" EXACT [GOC:TermGenie] synonym: "organic cyclic compound catabolism" EXACT [GOC:TermGenie] synonym: "organic cyclic compound degradation" EXACT [GOC:TermGenie] is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901575 ! organic substance catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: bf creation_date: 2012-09-14T09:05:04Z [Term] id: GO:1901362 name: organic cyclic compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of organic cyclic compound." [GOC:TermGenie] synonym: "organic cyclic compound anabolism" EXACT [GOC:TermGenie] synonym: "organic cyclic compound biosynthesis" EXACT [GOC:TermGenie] synonym: "organic cyclic compound formation" EXACT [GOC:TermGenie] synonym: "organic cyclic compound synthesis" EXACT [GOC:TermGenie] is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901576 ! organic substance biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: bf creation_date: 2012-09-14T09:05:22Z [Term] id: GO:1901363 name: heterocyclic compound binding namespace: molecular_function def: "Interacting selectively and non-covalently with heterocyclic compound." [GOC:TermGenie] is_a: GO:0005488 ! binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: bf creation_date: 2012-09-14T13:53:50Z [Term] id: GO:1901522 name: positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus namespace: biological_process def: "Any positive regulation of transcription from RNA polymerase II promoter that is involved in cellular response to chemical stimulus." [GOC:TermGenie, PMID:22840777] synonym: "activation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie] synonym: "activation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" NARROW [GOC:TermGenie] synonym: "positive regulation of gene-specific transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie] synonym: "positive regulation of global transcription from Pol II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie] synonym: "positive regulation of transcription from Pol II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie] synonym: "stimulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" NARROW [GOC:TermGenie] synonym: "stimulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie] synonym: "up regulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie] synonym: "up regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie] synonym: "up-regulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie] synonym: "up-regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie] synonym: "upregulation of global transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" RELATED [GOC:TermGenie] synonym: "upregulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus" EXACT [GOC:TermGenie] is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter intersection_of: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter intersection_of: part_of GO:0070887 ! cellular response to chemical stimulus relationship: part_of GO:0070887 ! cellular response to chemical stimulus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: al creation_date: 2012-10-19T08:25:05Z [Term] id: GO:1901560 name: response to purvalanol A namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purvalanol A stimulus." [GOC:TermGenie] is_a: GO:0014074 ! response to purine-containing compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2012-11-02T15:32:28Z [Term] id: GO:1901563 name: response to camptothecin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus." [GOC:TermGenie] synonym: "response to CPT" EXACT [GOC:mah] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0043279 ! response to alkaloid is_a: GO:1901700 ! response to oxygen-containing compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2012-11-02T15:32:45Z [Term] id: GO:1901564 name: organonitrogen compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organonitrogen compound." [GOC:pr, GOC:TermGenie] synonym: "organonitrogen compound metabolism" EXACT [GOC:TermGenie] is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0071704 ! organic substance metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: pr creation_date: 2012-11-04T15:17:52Z [Term] id: GO:1901565 name: organonitrogen compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of organonitrogen compound." [GOC:pr, GOC:TermGenie] synonym: "organonitrogen compound breakdown" EXACT [GOC:TermGenie] synonym: "organonitrogen compound catabolism" EXACT [GOC:TermGenie] synonym: "organonitrogen compound degradation" EXACT [GOC:TermGenie] is_a: GO:1901564 ! organonitrogen compound metabolic process is_a: GO:1901575 ! organic substance catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: pr creation_date: 2012-11-04T15:17:56Z [Term] id: GO:1901566 name: organonitrogen compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of organonitrogen compound." [GOC:pr, GOC:TermGenie] synonym: "organonitrogen compound anabolism" EXACT [GOC:TermGenie] synonym: "organonitrogen compound biosynthesis" EXACT [GOC:TermGenie] synonym: "organonitrogen compound formation" EXACT [GOC:TermGenie] synonym: "organonitrogen compound synthesis" EXACT [GOC:TermGenie] is_a: GO:1901564 ! organonitrogen compound metabolic process is_a: GO:1901576 ! organic substance biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: pr creation_date: 2012-11-04T15:18:00Z [Term] id: GO:1901575 name: organic substance catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon." [GOC:pr, GOC:TermGenie] synonym: "organic molecular entity breakdown" EXACT [GOC:TermGenie] synonym: "organic molecular entity catabolic process" EXACT [] synonym: "organic molecular entity catabolism" EXACT [GOC:TermGenie] synonym: "organic molecular entity degradation" EXACT [GOC:TermGenie] synonym: "organic substance breakdown" EXACT [] synonym: "organic substance catabolism" EXACT [] synonym: "organic substance degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0071704 ! organic substance metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: pr creation_date: 2012-11-05T11:04:36Z [Term] id: GO:1901576 name: organic substance biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon." [GOC:pr, GOC:TermGenie] synonym: "organic molecular entity anabolism" EXACT [GOC:TermGenie] synonym: "organic molecular entity biosynthesis" EXACT [GOC:TermGenie] synonym: "organic molecular entity biosynthetic process" EXACT [] synonym: "organic molecular entity formation" EXACT [GOC:TermGenie] synonym: "organic molecular entity synthesis" EXACT [GOC:TermGenie] synonym: "organic substance anabolism" EXACT [] synonym: "organic substance biosynthesis" EXACT [] synonym: "organic substance formation" EXACT [] synonym: "organic substance synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0071704 ! organic substance metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: pr creation_date: 2012-11-05T11:04:40Z [Term] id: GO:1901605 name: alpha-amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an alpha-amino acid." [GOC:TermGenie] synonym: "alpha-amino acid metabolism" EXACT [GOC:TermGenie] is_a: GO:0006520 ! cellular amino acid metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tb creation_date: 2012-11-08T17:39:50Z [Term] id: GO:1901606 name: alpha-amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid." [GOC:TermGenie] synonym: "alpha-amino acid breakdown" EXACT [GOC:TermGenie] synonym: "alpha-amino acid catabolism" EXACT [GOC:TermGenie] synonym: "alpha-amino acid degradation" EXACT [GOC:TermGenie] is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tb creation_date: 2012-11-08T17:39:54Z [Term] id: GO:1901607 name: alpha-amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an alpha-amino acid." [GOC:TermGenie] synonym: "alpha-amino acid anabolism" EXACT [GOC:TermGenie] synonym: "alpha-amino acid biosynthesis" EXACT [GOC:TermGenie] synonym: "alpha-amino acid formation" EXACT [GOC:TermGenie] synonym: "alpha-amino acid synthesis" EXACT [GOC:TermGenie] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:1901605 ! alpha-amino acid metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tb creation_date: 2012-11-08T17:39:58Z [Term] id: GO:1901615 name: organic hydroxy compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic hydroxy compound." [GOC:pr, GOC:TermGenie] synonym: "organic hydroxy compound metabolism" EXACT [GOC:TermGenie] is_a: GO:0071704 ! organic substance metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: pr creation_date: 2012-11-13T12:54:27Z [Term] id: GO:1901617 name: organic hydroxy compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of organic hydroxy compound." [GOC:pr, GOC:TermGenie] synonym: "organic hydroxy compound anabolism" EXACT [GOC:TermGenie] synonym: "organic hydroxy compound biosynthesis" EXACT [GOC:TermGenie] synonym: "organic hydroxy compound formation" EXACT [GOC:TermGenie] synonym: "organic hydroxy compound synthesis" EXACT [GOC:TermGenie] is_a: GO:1901576 ! organic substance biosynthetic process is_a: GO:1901615 ! organic hydroxy compound metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: pr creation_date: 2012-11-13T12:54:36Z [Term] id: GO:1901654 name: response to ketone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus." [GOC:pr, GOC:TermGenie] is_a: GO:0010033 ! response to organic substance is_a: GO:1901700 ! response to oxygen-containing compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: pr creation_date: 2012-11-20T10:55:47Z [Term] id: GO:1901655 name: cellular response to ketone namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ketone stimulus." [GOC:pr, GOC:TermGenie] is_a: GO:1901654 ! response to ketone is_a: GO:1901701 ! cellular response to oxygen-containing compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: pr creation_date: 2012-11-20T10:55:51Z [Term] id: GO:1901657 name: glycosyl compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycosyl compound." [GOC:pr, GOC:TermGenie] synonym: "glycosyl compound metabolism" EXACT [GOC:TermGenie] is_a: GO:0044710 ! single-organism metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: pr creation_date: 2012-11-20T14:24:07Z [Term] id: GO:1901659 name: glycosyl compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycosyl compound." [GOC:pr, GOC:TermGenie] synonym: "glycosyl compound anabolism" EXACT [GOC:TermGenie] synonym: "glycosyl compound biosynthesis" EXACT [GOC:TermGenie] synonym: "glycosyl compound formation" EXACT [GOC:TermGenie] synonym: "glycosyl compound synthesis" EXACT [GOC:TermGenie] is_a: GO:0044711 ! single-organism biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process is_a: GO:1901657 ! glycosyl compound metabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: pr creation_date: 2012-11-20T14:24:19Z [Term] id: GO:1901660 name: calcium ion export namespace: biological_process def: "The directed movement of calcium ion out of a cell or organelle." [GOC:TermGenie] is_a: GO:0030001 ! metal ion transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2012-11-20T14:33:07Z [Term] id: GO:1901679 name: nucleotide transmembrane transport namespace: biological_process def: "The directed movement of nucleotide across a membrane." [GOC:pr, GOC:TermGenie] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "nucleotide membrane transport" EXACT [] is_a: GO:0006862 ! nucleotide transport is_a: GO:0055085 ! transmembrane transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: pr creation_date: 2012-11-22T15:43:23Z [Term] id: GO:1901688 name: pantothenate import namespace: biological_process def: "The directed movement of pantothenate into a cell or organelle." [GOC:TermGenie] is_a: GO:0042886 ! amide transport is_a: GO:0072337 ! modified amino acid transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2012-12-05T16:27:41Z [Term] id: GO:1901689 name: biotin import namespace: biological_process def: "The directed movement of biotin into a cell or organelle." [GOC:TermGenie] is_a: GO:0015878 ! biotin transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2012-12-05T16:30:20Z [Term] id: GO:1901698 name: response to nitrogen compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] synonym: "response to nitrogen molecular entity" EXACT [] is_a: GO:0042221 ! response to chemical property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: pr creation_date: 2012-12-13T15:06:08Z [Term] id: GO:1901699 name: cellular response to nitrogen compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen compound stimulus." [GOC:pr, GOC:TermGenie] synonym: "cellular response to nitrogen molecular entity" EXACT [] is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:1901698 ! response to nitrogen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: pr creation_date: 2012-12-13T15:06:13Z [Term] id: GO:1901700 name: response to oxygen-containing compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] synonym: "response to oxygen molecular entity" EXACT [] is_a: GO:0042221 ! response to chemical property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: pr creation_date: 2012-12-13T15:11:37Z [Term] id: GO:1901701 name: cellular response to oxygen-containing compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." [GOC:pr, GOC:TermGenie] synonym: "cellular response to oxygen molecular entity" EXACT [] is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:1901700 ! response to oxygen-containing compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: pr creation_date: 2012-12-13T15:11:42Z [Term] id: GO:1901707 name: leptomycin B binding namespace: molecular_function def: "Interacting selectively and non-covalently with leptomycin B." [GOC:TermGenie] is_a: GO:0005504 ! fatty acid binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2012-12-18T15:10:04Z [Term] id: GO:1901799 name: negative regulation of proteasomal protein catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of proteasomal protein catabolic process." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198] synonym: "down regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie] synonym: "inhibition of proteasomal protein catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie] is_a: GO:0061136 ! regulation of proteasomal protein catabolic process is_a: GO:1903051 ! negative regulation of proteolysis involved in cellular protein catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0010498 ! proteasomal protein catabolic process relationship: negatively_regulates GO:0010498 ! proteasomal protein catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rl creation_date: 2013-01-21T20:10:54Z [Term] id: GO:1901800 name: positive regulation of proteasomal protein catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process." [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:21669198] synonym: "activation of proteasomal protein catabolic process" NARROW [GOC:TermGenie] synonym: "activation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie] synonym: "activation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of proteasomal protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of proteasome-mediated protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of proteasome-mediated protein catabolism" EXACT [GOC:TermGenie] is_a: GO:0061136 ! regulation of proteasomal protein catabolic process is_a: GO:1903052 ! positive regulation of proteolysis involved in cellular protein catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0010498 ! proteasomal protein catabolic process relationship: positively_regulates GO:0010498 ! proteasomal protein catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rl creation_date: 2013-01-21T20:10:58Z [Term] id: GO:1901970 name: positive regulation of mitotic sister chromatid separation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic sister chromatid separation." [GOC:TermGenie, PMID:1846086] synonym: "activation of chromosome separation during mitosis" RELATED [GOC:TermGenie] synonym: "activation of mitotic chromosome separation" RELATED [GOC:TermGenie] synonym: "activation of mitotic sister chromatid resolution" EXACT [GOC:TermGenie] synonym: "activation of mitotic sister chromatid separation" NARROW [GOC:TermGenie] synonym: "activation of sister chromatid separation during mitosis" EXACT [GOC:TermGenie] synonym: "positive regulation of chromosome separation during mitosis" RELATED [GOC:TermGenie] synonym: "positive regulation of mitotic chromosome separation" RELATED [GOC:TermGenie] synonym: "positive regulation of mitotic sister chromatid resolution" EXACT [GOC:TermGenie] synonym: "positive regulation of sister chromatid separation during mitosis" EXACT [GOC:TermGenie] synonym: "up regulation of chromosome separation during mitosis" RELATED [GOC:TermGenie] synonym: "up regulation of mitotic chromosome separation" RELATED [GOC:TermGenie] synonym: "up regulation of mitotic sister chromatid resolution" EXACT [GOC:TermGenie] synonym: "up regulation of mitotic sister chromatid separation" EXACT [GOC:TermGenie] synonym: "up regulation of sister chromatid separation during mitosis" EXACT [GOC:TermGenie] synonym: "up-regulation of chromosome separation during mitosis" RELATED [GOC:TermGenie] synonym: "up-regulation of mitotic chromosome separation" RELATED [GOC:TermGenie] synonym: "up-regulation of mitotic sister chromatid resolution" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic sister chromatid separation" EXACT [GOC:TermGenie] synonym: "up-regulation of sister chromatid separation during mitosis" EXACT [GOC:TermGenie] synonym: "upregulation of chromosome separation during mitosis" RELATED [GOC:TermGenie] synonym: "upregulation of mitotic chromosome separation" RELATED [GOC:TermGenie] synonym: "upregulation of mitotic sister chromatid resolution" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic sister chromatid separation" EXACT [GOC:TermGenie] synonym: "upregulation of sister chromatid separation during mitosis" EXACT [GOC:TermGenie] is_a: GO:0010965 ! regulation of mitotic sister chromatid separation is_a: GO:0045840 ! positive regulation of mitotic nuclear division is_a: GO:0051984 ! positive regulation of chromosome segregation is_a: GO:2001252 ! positive regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0051306 ! mitotic sister chromatid separation relationship: positively_regulates GO:0051306 ! mitotic sister chromatid separation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: al creation_date: 2013-02-22T19:06:19Z [Term] id: GO:1901976 name: regulation of cell cycle checkpoint namespace: biological_process alt_id: GO:2001047 def: "Any process that modulates the frequency, rate or extent of cell cycle checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:23028116] comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc). subset: gocheck_do_not_manually_annotate synonym: "regulation of G1/S checkpoint" RELATED [GOC:obol] synonym: "regulation of G1/S transition checkpoint" RELATED [] is_a: GO:0010564 ! regulation of cell cycle process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0000075 ! cell cycle checkpoint relationship: regulates GO:0000075 ! cell cycle checkpoint property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2013-03-06T15:10:20Z [Term] id: GO:1901978 name: positive regulation of cell cycle checkpoint namespace: biological_process alt_id: GO:2001052 def: "Any process that activates or increases the frequency, rate or extent of cell cycle checkpoint." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:23028116] synonym: "activation of cell cycle checkpoint" NARROW [GOC:TermGenie] synonym: "positive regulation of G1/S checkpoint" RELATED [GOC:obol] synonym: "positive regulation of G1/S transition checkpoint" RELATED [] synonym: "up regulation of cell cycle checkpoint" EXACT [GOC:TermGenie] synonym: "up-regulation of cell cycle checkpoint" EXACT [GOC:TermGenie] synonym: "upregulation of cell cycle checkpoint" EXACT [GOC:TermGenie] is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:1901976 ! regulation of cell cycle checkpoint intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0000075 ! cell cycle checkpoint relationship: positively_regulates GO:0000075 ! cell cycle checkpoint property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2013-03-06T15:10:34Z [Term] id: GO:1901987 name: regulation of cell cycle phase transition namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] synonym: "cell cycle control" EXACT [GOC:vw] synonym: "regulation of cell cycle transition" EXACT [GOC:TermGenie] is_a: GO:0010564 ! regulation of cell cycle process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0044770 ! cell cycle phase transition relationship: regulates GO:0044770 ! cell cycle phase transition property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2013-03-19T16:11:27Z [Term] id: GO:1901988 name: negative regulation of cell cycle phase transition namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] synonym: "down regulation of cell cycle phase transition" EXACT [GOC:TermGenie] synonym: "down regulation of cell cycle transition" EXACT [GOC:TermGenie] synonym: "down-regulation of cell cycle phase transition" EXACT [GOC:TermGenie] synonym: "down-regulation of cell cycle transition" EXACT [GOC:TermGenie] synonym: "downregulation of cell cycle phase transition" EXACT [GOC:TermGenie] synonym: "downregulation of cell cycle transition" EXACT [GOC:TermGenie] synonym: "inhibition of cell cycle phase transition" NARROW [GOC:TermGenie] synonym: "inhibition of cell cycle transition" EXACT [GOC:TermGenie] synonym: "negative regulation of cell cycle transition" EXACT [GOC:TermGenie] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:1901987 ! regulation of cell cycle phase transition intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0044770 ! cell cycle phase transition relationship: negatively_regulates GO:0044770 ! cell cycle phase transition property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2013-03-19T16:11:32Z [Term] id: GO:1901989 name: positive regulation of cell cycle phase transition namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] synonym: "activation of cell cycle phase transition" NARROW [GOC:TermGenie] synonym: "activation of cell cycle transition" EXACT [GOC:TermGenie] synonym: "positive regulation of cell cycle transition" EXACT [GOC:TermGenie] synonym: "up regulation of cell cycle phase transition" EXACT [GOC:TermGenie] synonym: "up regulation of cell cycle transition" EXACT [GOC:TermGenie] synonym: "up-regulation of cell cycle phase transition" EXACT [GOC:TermGenie] synonym: "up-regulation of cell cycle transition" EXACT [GOC:TermGenie] synonym: "upregulation of cell cycle phase transition" EXACT [GOC:TermGenie] synonym: "upregulation of cell cycle transition" EXACT [GOC:TermGenie] is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:1901987 ! regulation of cell cycle phase transition intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0044770 ! cell cycle phase transition relationship: positively_regulates GO:0044770 ! cell cycle phase transition property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2013-03-19T16:11:37Z [Term] id: GO:1901990 name: regulation of mitotic cell cycle phase transition namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] synonym: "mitotic cell cycle control" EXACT [GOC:vw] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:1901987 ! regulation of cell cycle phase transition intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0044772 ! mitotic cell cycle phase transition relationship: regulates GO:0044772 ! mitotic cell cycle phase transition property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2013-03-19T16:14:38Z [Term] id: GO:1901991 name: negative regulation of mitotic cell cycle phase transition namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] synonym: "down regulation of mitotic cell cycle phase transition" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic cell cycle phase transition" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic cell cycle phase transition" EXACT [GOC:TermGenie] synonym: "inhibition of mitotic cell cycle phase transition" NARROW [GOC:TermGenie] is_a: GO:0045930 ! negative regulation of mitotic cell cycle is_a: GO:1901988 ! negative regulation of cell cycle phase transition is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0044772 ! mitotic cell cycle phase transition relationship: negatively_regulates GO:0044772 ! mitotic cell cycle phase transition property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2013-03-19T16:14:46Z [Term] id: GO:1901992 name: positive regulation of mitotic cell cycle phase transition namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitotic cell cycle phase transition." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:22841721] synonym: "activation of mitotic cell cycle phase transition" NARROW [GOC:TermGenie] synonym: "up regulation of mitotic cell cycle phase transition" EXACT [GOC:TermGenie] synonym: "up-regulation of mitotic cell cycle phase transition" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic cell cycle phase transition" EXACT [GOC:TermGenie] is_a: GO:0045931 ! positive regulation of mitotic cell cycle is_a: GO:1901989 ! positive regulation of cell cycle phase transition is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0044772 ! mitotic cell cycle phase transition relationship: positively_regulates GO:0044772 ! mitotic cell cycle phase transition property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2013-03-19T16:14:51Z [Term] id: GO:1902022 name: L-lysine transport namespace: biological_process def: "The directed movement of a L-lysine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:kmv, GOC:TermGenie, PMID:22822152] is_a: GO:0015807 ! L-amino acid transport is_a: GO:0015819 ! lysine transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: kmv creation_date: 2013-03-27T16:09:06Z [Term] id: GO:1902023 name: L-arginine transport namespace: biological_process def: "The directed movement of a L-arginine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:kmv, GOC:TermGenie, PMID:22822152] is_a: GO:0015807 ! L-amino acid transport is_a: GO:0015809 ! arginine transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: kmv creation_date: 2013-03-27T16:09:11Z [Term] id: GO:1902024 name: L-histidine transport namespace: biological_process def: "The directed movement of a L-histidine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:kmv, GOC:TermGenie, PMID:22822152] is_a: GO:0015807 ! L-amino acid transport is_a: GO:0015817 ! histidine transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: kmv creation_date: 2013-03-27T16:09:15Z [Term] id: GO:1902099 name: regulation of metaphase/anaphase transition of cell cycle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of metaphase/anaphase transition of cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] is_a: GO:1901987 ! regulation of cell cycle phase transition intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0044784 ! metaphase/anaphase transition of cell cycle relationship: regulates GO:0044784 ! metaphase/anaphase transition of cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2013-05-02T12:45:15Z [Term] id: GO:1902100 name: negative regulation of metaphase/anaphase transition of cell cycle namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "down regulation of metaphase/anaphase transition of cell cycle" EXACT [GOC:TermGenie] synonym: "down-regulation of metaphase/anaphase transition of cell cycle" EXACT [GOC:TermGenie] synonym: "downregulation of metaphase/anaphase transition of cell cycle" EXACT [GOC:TermGenie] synonym: "inhibition of metaphase/anaphase transition of cell cycle" NARROW [GOC:TermGenie] is_a: GO:1901988 ! negative regulation of cell cycle phase transition is_a: GO:1902099 ! regulation of metaphase/anaphase transition of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0044784 ! metaphase/anaphase transition of cell cycle relationship: negatively_regulates GO:0044784 ! metaphase/anaphase transition of cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2013-05-02T12:45:20Z [Term] id: GO:1902101 name: positive regulation of metaphase/anaphase transition of cell cycle namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "activation of metaphase/anaphase transition of cell cycle" NARROW [GOC:TermGenie] synonym: "up regulation of metaphase/anaphase transition of cell cycle" EXACT [GOC:TermGenie] synonym: "up-regulation of metaphase/anaphase transition of cell cycle" EXACT [GOC:TermGenie] synonym: "upregulation of metaphase/anaphase transition of cell cycle" EXACT [GOC:TermGenie] is_a: GO:1901989 ! positive regulation of cell cycle phase transition is_a: GO:1902099 ! regulation of metaphase/anaphase transition of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0044784 ! metaphase/anaphase transition of cell cycle relationship: positively_regulates GO:0044784 ! metaphase/anaphase transition of cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2013-05-02T12:45:30Z [Term] id: GO:1902111 name: response to diethyl maleate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diethyl maleate stimulus." [GOC:TermGenie, PMID:12100563] is_a: GO:0010033 ! response to organic substance is_a: GO:1901700 ! response to oxygen-containing compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2013-05-08T16:00:35Z [Term] id: GO:1902112 name: cellular response to diethyl maleate namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diethyl maleate stimulus." [GOC:TermGenie, PMID:12100563] is_a: GO:1901701 ! cellular response to oxygen-containing compound is_a: GO:1902111 ! response to diethyl maleate property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2013-05-08T16:00:40Z [Term] id: GO:1902170 name: cellular response to reactive nitrogen species namespace: biological_process alt_id: GO:1990106 def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive nitrogen species stimulus." [GOC:sl, GOC:TermGenie, PMID:22504638] is_a: GO:1901699 ! cellular response to nitrogen compound property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tb creation_date: 2013-05-23T00:23:59Z [Term] id: GO:1902248 name: 5-O-phosphono-alpha-D-ribofuranosyl diphosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with 5-O-phosphono-alpha-D-ribofuranosyl diphosphate." [GOC:mah, GOC:TermGenie, PMID:4314233] synonym: "5-phosphoribose 1-diphosphate binding" EXACT [GOC:curators] synonym: "phosphoribosylpyrophosphate binding" EXACT [GOC:al] is_a: GO:0043168 ! anion binding is_a: GO:0097367 ! carbohydrate derivative binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2013-06-20T16:20:29Z [Term] id: GO:1902249 name: IMP binding namespace: molecular_function def: "Interacting selectively and non-covalently with IMP, inosine monophosphate." [GOC:mah, GOC:TermGenie, PMID:4314233] is_a: GO:0032555 ! purine ribonucleotide binding is_a: GO:0043168 ! anion binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2013-06-20T16:20:35Z [Term] id: GO:1902292 name: cell cycle DNA replication initiation namespace: biological_process def: "Any DNA replication initiation that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "DNA endoreduplication initiation involved in cell cycle DNA replication" NARROW [GOC:TermGenie] synonym: "DNA re-replication initiation involved in cell cycle DNA replication" NARROW [GOC:TermGenie] synonym: "DNA replication initiation involved in cell cycle DNA replication" EXACT [] synonym: "DNA-dependent DNA replication initiation involved in cell cycle DNA replication" EXACT [GOC:TermGenie] is_a: GO:0006270 ! DNA replication initiation is_a: GO:0022402 ! cell cycle process is_a: GO:0044710 ! single-organism metabolic process intersection_of: GO:0006270 ! DNA replication initiation intersection_of: part_of GO:0044786 ! cell cycle DNA replication relationship: part_of GO:0044786 ! cell cycle DNA replication property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2013-07-09T16:05:54Z [Term] id: GO:1902296 name: DNA strand elongation involved in cell cycle DNA replication namespace: biological_process def: "Any DNA strand elongation that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "DNA replication elongation involved in cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "DNA strand elongation during DNA replication involved in cell cycle DNA replication" RELATED [GOC:TermGenie] is_a: GO:0006271 ! DNA strand elongation involved in DNA replication is_a: GO:0022402 ! cell cycle process is_a: GO:0044710 ! single-organism metabolic process intersection_of: GO:0006271 ! DNA strand elongation involved in DNA replication intersection_of: part_of GO:0044786 ! cell cycle DNA replication relationship: part_of GO:0044786 ! cell cycle DNA replication property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2013-07-10T11:47:02Z [Term] id: GO:1902299 name: pre-replicative complex assembly involved in cell cycle DNA replication namespace: biological_process def: "Any pre-replicative complex assembly that is involved in cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "pre-RC assembly involved in cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "pre-replication complex assembly involved in cell cycle DNA replication" RELATED [GOC:TermGenie] is_a: GO:0022402 ! cell cycle process is_a: GO:0036388 ! pre-replicative complex assembly intersection_of: GO:0036388 ! pre-replicative complex assembly intersection_of: part_of GO:0044786 ! cell cycle DNA replication relationship: part_of GO:0044786 ! cell cycle DNA replication property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2013-07-10T11:47:28Z [Term] id: GO:1902315 name: nuclear cell cycle DNA replication initiation namespace: biological_process def: "Any DNA replication initiation that is involved in nuclear cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "DNA endoreduplication initiation involved in nuclear cell cycle DNA replication" NARROW [GOC:TermGenie] synonym: "DNA re-replication initiation involved in nuclear cell cycle DNA replication" NARROW [GOC:TermGenie] synonym: "DNA replication initiation involved in nuclear cell cycle DNA replication" EXACT [] is_a: GO:1902292 ! cell cycle DNA replication initiation intersection_of: GO:0006270 ! DNA replication initiation intersection_of: part_of GO:0033260 ! nuclear DNA replication relationship: part_of GO:0033260 ! nuclear DNA replication property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2013-07-23T14:00:01Z [Term] id: GO:1902319 name: DNA strand elongation involved in nuclear cell cycle DNA replication namespace: biological_process def: "Any DNA strand elongation that is involved in nuclear cell cycle DNA replication." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "DNA strand elongation involved in DNA replication during S phase" RELATED [GOC:TermGenie] synonym: "DNA strand elongation involved in DNA replication involved in S phase" EXACT [GOC:TermGenie] synonym: "DNA strand elongation involved in DNA replication involved in S-phase" EXACT [GOC:TermGenie] is_a: GO:1902296 ! DNA strand elongation involved in cell cycle DNA replication intersection_of: GO:0022616 ! DNA strand elongation intersection_of: part_of GO:0033260 ! nuclear DNA replication relationship: part_of GO:0033260 ! nuclear DNA replication property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2013-07-23T14:00:41Z [Term] id: GO:1902368 name: heterochromatin maintenance involved in chromatin silencing at centromere outer repeat region namespace: biological_process def: "Any heterochromatin maintenance that is involved in chromatin silencing at centromere outer repeat region." [GOC:TermGenie, GOC:vw, PMID:21289066] synonym: "heterochromatin maintenance involved in chromatin silencing at centromeric outer repeats" EXACT [GOC:vw] synonym: "heterochromatin maintenance involved in chromatin silencing at pericentric region" RELATED [GOC:TermGenie] is_a: GO:0070870 ! heterochromatin maintenance involved in chromatin silencing intersection_of: GO:0070829 ! heterochromatin maintenance intersection_of: part_of GO:1990141 ! chromatin silencing at centromere outer repeat region relationship: part_of GO:1990141 ! chromatin silencing at centromere outer repeat region property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: bf creation_date: 2013-08-21T10:13:39Z [Term] id: GO:1902404 name: mitotic actomyosin contractile ring contraction namespace: biological_process def: "Any actomyosin contractile ring contraction that is involved in mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "contractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "cytokinesis, actomyosin ring contraction involved in mitotic cell cycle" EXACT [GOC:TermGenie] is_a: GO:0000916 ! actomyosin contractile ring contraction is_a: GO:1902410 ! mitotic cytokinetic process intersection_of: GO:0000916 ! actomyosin contractile ring contraction intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000281 ! mitotic cytokinesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2013-09-12T12:27:57Z [Term] id: GO:1902405 name: mitotic actomyosin contractile ring localization namespace: biological_process def: "Any actomyosin contractile ring localization that is involved in mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "contractile ring localisation involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "contractile ring localization involved in cell cycle cytokinesis involved in mitotic cell cycle" EXACT [GOC:TermGenie] is_a: GO:0032187 ! actomyosin contractile ring localization is_a: GO:1902410 ! mitotic cytokinetic process intersection_of: GO:0032187 ! actomyosin contractile ring localization intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000281 ! mitotic cytokinesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2013-09-12T12:28:05Z [Term] id: GO:1902410 name: mitotic cytokinetic process namespace: biological_process def: "Any cytokinetic process that is involved in mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:TermGenie] is_a: GO:0032506 ! cytokinetic process is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0032506 ! cytokinetic process intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000281 ! mitotic cytokinesis relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2013-09-12T12:29:36Z [Term] id: GO:1902432 name: protein localization to barrier septum namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a barrier septum." [GOC:TermGenie, PMID:9367977] synonym: "protein localisation in barrier septum" EXACT [GOC:TermGenie] synonym: "protein localisation to barrier septum" EXACT [GOC:TermGenie] synonym: "protein localization in barrier septum" EXACT [GOC:TermGenie] is_a: GO:0034613 ! cellular protein localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2013-09-30T14:29:51Z [Term] id: GO:1902434 name: sulfate import into cell namespace: biological_process def: "The directed movement of sulfate from outside of a cell into the intracellular region of a cell." [GOC:TermGenie, PMID:14723223] synonym: "sulphate import into cell" EXACT [] is_a: GO:0008272 ! sulfate transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2013-10-07T14:12:38Z [Term] id: GO:1902440 name: protein localization to mitotic spindle pole body namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a mitotic spindle pole body." [GOC:TermGenie, PMID:22438582] synonym: "protein localisation in mitotic spindle pole body" EXACT [GOC:TermGenie] synonym: "protein localisation to mitotic spindle pole body" EXACT [GOC:TermGenie] synonym: "protein localization in mitotic spindle pole body" EXACT [GOC:TermGenie] is_a: GO:0071988 ! protein localization to spindle pole body is_a: GO:1902480 ! protein localization to mitotic spindle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2013-10-10T14:44:55Z [Term] id: GO:1902441 name: protein localization to meiotic spindle pole body namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a meiotic spindle pole body." [GOC:TermGenie, PMID:22438582] synonym: "protein localisation in meiotic spindle pole body" EXACT [GOC:TermGenie] synonym: "protein localisation to meiotic spindle pole body" EXACT [GOC:TermGenie] synonym: "protein localization in meiotic spindle pole body" EXACT [GOC:TermGenie] is_a: GO:0071988 ! protein localization to spindle pole body relationship: part_of GO:1990395 ! meiotic spindle pole body organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2013-10-10T14:45:04Z [Term] id: GO:1902444 name: riboflavin binding namespace: molecular_function def: "Interacting selectively and non-covalently with riboflavin." [GOC:TermGenie, PMID:12083520] is_a: GO:0043168 ! anion binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: al creation_date: 2013-10-11T08:44:52Z [Term] id: GO:1902480 name: protein localization to mitotic spindle namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a mitotic spindle." [GOC:TermGenie, PMID:23885124] synonym: "protein localisation in mitotic spindle" EXACT [GOC:TermGenie] synonym: "protein localisation to mitotic spindle" EXACT [GOC:TermGenie] synonym: "protein localization in mitotic spindle" EXACT [GOC:TermGenie] is_a: GO:0072698 ! protein localization to microtubule cytoskeleton property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2013-11-04T13:16:47Z [Term] id: GO:1902481 name: gamma-tubulin complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a gamma-tubulin complex." [GOC:TermGenie, PMID:23885124] synonym: "gamma-tubulin complex formation" EXACT [GOC:TermGenie] is_a: GO:0006461 ! protein complex assembly property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2013-11-04T13:21:12Z [Term] id: GO:1902486 name: protein localization to growing cell tip namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a growing cell tip." [GOC:TermGenie, PMID:23041194] synonym: "protein localisation in growing cell tip" EXACT [GOC:TermGenie] synonym: "protein localisation to growing cell tip" EXACT [GOC:TermGenie] synonym: "protein localization in growing cell tip" EXACT [GOC:TermGenie] is_a: GO:1990151 ! protein localization to cell tip property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2013-11-12T16:38:13Z [Term] id: GO:1902487 name: protein localization to non-growing cell tip namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a non-growing cell tip." [GOC:TermGenie, PMID:21652630, PMID:23041194] synonym: "protein localisation in non-growing cell tip" EXACT [GOC:TermGenie] synonym: "protein localisation to non-growing cell tip" EXACT [GOC:TermGenie] synonym: "protein localization in non-growing cell tip" EXACT [GOC:TermGenie] is_a: GO:1990151 ! protein localization to cell tip property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2013-11-12T16:38:22Z [Term] id: GO:1902494 name: catalytic complex namespace: cellular_component def: "A protein complex which is capable of catalytic activity." [GOC:bhm, GOC:TermGenie, PMID:8077207] synonym: "enzyme complex" EXACT [GOC:bhm, GOC:jl] is_a: GO:0043234 ! protein complex property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: bhm creation_date: 2013-11-13T16:18:47Z [Term] id: GO:1902549 name: protein localization to Mei2 nuclear dot namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a Mei2 nuclear dot." [GOC:TermGenie, PMID:23980030] synonym: "protein localisation in Mei2 nuclear dot" EXACT [GOC:TermGenie] synonym: "protein localisation to Mei2 nuclear dot" EXACT [GOC:TermGenie] synonym: "protein localization in Mei2 nuclear dot" EXACT [GOC:TermGenie] synonym: "protein localization to Mei2 dot" EXACT [] is_a: GO:0034504 ! protein localization to nucleus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2013-12-04T16:17:06Z [Term] id: GO:1902561 name: origin recognition complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an origin recognition complex." [GOC:TermGenie, PMID:11717425] synonym: "ORC assembly" EXACT [GOC:TermGenie] synonym: "ORC formation" EXACT [GOC:TermGenie] synonym: "origin of replication recognition complex assembly" EXACT [GOC:TermGenie] synonym: "origin of replication recognition complex formation" EXACT [GOC:TermGenie] synonym: "origin recognition complex formation" EXACT [GOC:TermGenie] is_a: GO:0006461 ! protein complex assembly property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2013-12-10T12:11:50Z [Term] id: GO:1902570 name: protein localization to nucleolus namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a nucleolus." [GOC:TermGenie, PMID:22809626] synonym: "protein localisation in nucleolus" EXACT [GOC:TermGenie] synonym: "protein localisation to nucleolus" EXACT [GOC:TermGenie] synonym: "protein localization in nucleolus" EXACT [GOC:TermGenie] is_a: GO:0034504 ! protein localization to nucleus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2013-12-10T16:25:28Z [Term] id: GO:1902576 name: negative regulation of nuclear cell cycle DNA replication namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear cell cycle DNA replication." [GOC:TermGenie, PMID:19033384] synonym: "down regulation of DNA replication during S phase" RELATED [GOC:TermGenie] synonym: "down regulation of DNA replication involved in S phase" EXACT [GOC:TermGenie] synonym: "down regulation of DNA replication involved in S-phase" EXACT [GOC:TermGenie] synonym: "down regulation of nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA replication during S phase" RELATED [GOC:TermGenie] synonym: "down-regulation of DNA replication involved in S phase" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA replication involved in S-phase" EXACT [GOC:TermGenie] synonym: "down-regulation of nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "downregulation of DNA replication during S phase" RELATED [GOC:TermGenie] synonym: "downregulation of DNA replication involved in S phase" EXACT [GOC:TermGenie] synonym: "downregulation of DNA replication involved in S-phase" EXACT [GOC:TermGenie] synonym: "downregulation of nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "inhibition of DNA replication during S phase" RELATED [GOC:TermGenie] synonym: "inhibition of DNA replication involved in S phase" NARROW [GOC:TermGenie] synonym: "inhibition of DNA replication involved in S-phase" NARROW [GOC:TermGenie] synonym: "inhibition of nuclear cell cycle DNA replication" NARROW [GOC:TermGenie] synonym: "negative regulation of DNA replication during S phase" RELATED [GOC:TermGenie] synonym: "negative regulation of DNA replication involved in S phase" EXACT [GOC:TermGenie] synonym: "negative regulation of DNA replication involved in S-phase" EXACT [GOC:TermGenie] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0033262 ! regulation of nuclear cell cycle DNA replication is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0033260 ! nuclear DNA replication relationship: negatively_regulates GO:0033260 ! nuclear DNA replication property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2013-12-17T14:03:02Z [Term] id: GO:1902577 name: protein localization to medial cortical node namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a medial cortical node." [GOC:TermGenie, PMID:24127216] synonym: "protein localisation in medial cortical node" EXACT [GOC:TermGenie] synonym: "protein localisation to medial cortical node" EXACT [GOC:TermGenie] synonym: "protein localization in medial cortical node" EXACT [GOC:TermGenie] is_a: GO:0071574 ! protein localization to medial cortex property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2013-12-17T14:09:28Z [Term] id: GO:1902578 name: single-organism localization namespace: biological_process def: "A localization which involves only one organism." [GO_REF:0000089, GOC:jl, PMID:1234] synonym: "single organism localization" EXACT [GOC:TermGenie] is_a: GO:0044699 ! single-organism process is_a: GO:0051179 ! localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2013-12-18T13:51:04Z [Term] id: GO:1902580 name: single-organism cellular localization namespace: biological_process def: "A cellular localization which involves only one organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie] synonym: "single organism cellular localization" EXACT [GOC:TermGenie] is_a: GO:0051641 ! cellular localization is_a: GO:1902578 ! single-organism localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2013-12-18T14:04:32Z [Term] id: GO:1902582 name: single-organism intracellular transport namespace: biological_process def: "An intracellular transport which involves only one organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie] synonym: "single organism intracellular transport" EXACT [GOC:TermGenie] is_a: GO:0044765 ! single-organism transport is_a: GO:0046907 ! intracellular transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2013-12-18T14:04:50Z [Term] id: GO:1902589 name: single-organism organelle organization namespace: biological_process def: "An organelle organization which involves only one organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie] synonym: "single organism organelle organization" EXACT [GOC:TermGenie] is_a: GO:0006996 ! organelle organization is_a: GO:0044763 ! single-organism cellular process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2013-12-19T15:25:51Z [Term] id: GO:1902593 name: single-organism nuclear import namespace: biological_process def: "A nuclear import which involves only one organism." [GO_REF:0000089, GOC:jl, GOC:TermGenie] synonym: "single organism nuclear import" EXACT [GOC:TermGenie] is_a: GO:0051170 ! nuclear import is_a: GO:1902582 ! single-organism intracellular transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2013-12-19T15:26:34Z [Term] id: GO:1902600 name: hydrogen ion transmembrane transport namespace: biological_process def: "The directed movement of hydrogen ion (proton) across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie] synonym: "hydrogen transmembrane transport" BROAD [] synonym: "proton transmembrane transport" EXACT [] is_a: GO:0015992 ! proton transport is_a: GO:0098662 ! inorganic cation transmembrane transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: pr creation_date: 2013-12-20T11:08:37Z [Term] id: GO:1902621 name: actomyosin contractile ring disassembly namespace: biological_process def: "The disaggregation of an actomyosin contractile ring into its constituent components." [GO_REF:0000079, GOC:TermGenie, PMID:14602073, PMID:22891673] synonym: "actomyosin ring disassembly" RELATED [GOC:TermGenie] synonym: "CAR disassembly" EXACT [GOC:TermGenie] synonym: "constriction ring disassembly" RELATED [GOC:TermGenie] synonym: "contractile actomyosin ring disassembly" EXACT [GOC:TermGenie] synonym: "cytokinetic ring disassembly" RELATED [GOC:TermGenie] is_a: GO:0022411 ! cellular component disassembly is_a: GO:0032506 ! cytokinetic process is_a: GO:0044837 ! actomyosin contractile ring organization relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-01-15T09:27:26Z [Term] id: GO:1902657 name: protein localization to prospore membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a prospore membrane." [GO_REF:0000087, GOC:dph, GOC:TermGenie, PMID:24036347] synonym: "protein localisation in prospore membrane" EXACT [GOC:TermGenie] synonym: "protein localisation to prospore membrane" EXACT [GOC:TermGenie] synonym: "protein localization in prospore membrane" EXACT [GOC:TermGenie] is_a: GO:0072657 ! protein localization to membrane property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: dph creation_date: 2014-01-28T15:11:13Z [Term] id: GO:1902666 name: protein localization to Mmi1 nuclear focus complex namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a Mmi1 nuclear focus complex." [GO_REF:0000087, GOC:TermGenie, PMID:23980030] synonym: "protein localisation in Mmi1 nuclear focus complex" EXACT [GOC:TermGenie] synonym: "protein localisation to Mmi1 nuclear focus complex" EXACT [GOC:TermGenie] synonym: "protein localization in Mmi1 nuclear focus complex" EXACT [GOC:TermGenie] is_a: GO:0034504 ! protein localization to nucleus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-01-30T10:42:17Z [Term] id: GO:1902679 name: negative regulation of RNA biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] synonym: "down regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "down regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "down regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "down regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "down regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "down-regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "downregulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "downregulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "downregulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "downregulation of RNA formation" EXACT [GOC:TermGenie] synonym: "downregulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "inhibition of RNA anabolism" NARROW [GOC:TermGenie] synonym: "inhibition of RNA biosynthesis" NARROW [GOC:TermGenie] synonym: "inhibition of RNA biosynthetic process" NARROW [GOC:TermGenie] synonym: "inhibition of RNA formation" NARROW [GOC:TermGenie] synonym: "inhibition of RNA synthesis" NARROW [GOC:TermGenie] synonym: "negative regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "negative regulation of RNA synthesis" EXACT [GOC:TermGenie] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051253 ! negative regulation of RNA metabolic process is_a: GO:2001141 ! regulation of RNA biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0032774 ! RNA biosynthetic process relationship: negatively_regulates GO:0032774 ! RNA biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2014-02-05T16:32:01Z [Term] id: GO:1902680 name: positive regulation of RNA biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of RNA biosynthetic process." [GO:jl, GO_REF:0000058, GOC:TermGenie] synonym: "activation of RNA anabolism" NARROW [GOC:TermGenie] synonym: "activation of RNA biosynthesis" NARROW [GOC:TermGenie] synonym: "activation of RNA biosynthetic process" NARROW [GOC:TermGenie] synonym: "activation of RNA formation" NARROW [GOC:TermGenie] synonym: "activation of RNA synthesis" NARROW [GOC:TermGenie] synonym: "positive regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "positive regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "up regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "up regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "up regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "up regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "up regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA formation" EXACT [GOC:TermGenie] synonym: "up-regulation of RNA synthesis" EXACT [GOC:TermGenie] synonym: "upregulation of RNA anabolism" EXACT [GOC:TermGenie] synonym: "upregulation of RNA biosynthesis" EXACT [GOC:TermGenie] synonym: "upregulation of RNA biosynthetic process" EXACT [GOC:TermGenie] synonym: "upregulation of RNA formation" EXACT [GOC:TermGenie] synonym: "upregulation of RNA synthesis" EXACT [GOC:TermGenie] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0051254 ! positive regulation of RNA metabolic process is_a: GO:2001141 ! regulation of RNA biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0032774 ! RNA biosynthetic process relationship: positively_regulates GO:0032774 ! RNA biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2014-02-05T16:32:10Z [Term] id: GO:1902682 name: protein localization to nuclear pericentric heterochromatin namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a nuclear pericentric heterochromatin." [GO_REF:0000087, GOC:TermGenie, PMID:20211136] synonym: "protein localisation in nuclear centromeric heterochromatin" EXACT [GOC:TermGenie] synonym: "protein localisation to nuclear centromeric heterochromatin" EXACT [GOC:TermGenie] synonym: "protein localization in nuclear centromeric heterochromatin" EXACT [GOC:TermGenie] is_a: GO:0034504 ! protein localization to nucleus is_a: GO:0071459 ! protein localization to chromosome, centromeric region is_a: GO:0097355 ! protein localization to heterochromatin property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-02-05T16:59:30Z [Term] id: GO:1902708 name: response to plumbagin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a plumbagin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23028742] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:1901654 ! response to ketone property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-02-20T13:49:54Z [Term] id: GO:1902709 name: cellular response to plumbagin namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a plumbagin stimulus." [GO_REF:0000071, GOC:TermGenie, PMID:23028742] is_a: GO:0071407 ! cellular response to organic cyclic compound is_a: GO:1901655 ! cellular response to ketone is_a: GO:1902708 ! response to plumbagin property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-02-20T13:50:04Z [Term] id: GO:1902749 name: regulation of cell cycle G2/M phase transition namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell cycle G2/M phase transition." [GO_REF:0000058, GOC:jl, GOC:TermGenie] is_a: GO:1901987 ! regulation of cell cycle phase transition intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0044839 ! cell cycle G2/M phase transition relationship: regulates GO:0044839 ! cell cycle G2/M phase transition property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2014-03-05T15:38:15Z [Term] id: GO:1902750 name: negative regulation of cell cycle G2/M phase transition namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle G2/M phase transition." [GO_REF:0000058, GOC:jl, GOC:TermGenie] synonym: "down regulation of cell cycle G2/M phase transition" EXACT [GOC:TermGenie] synonym: "down-regulation of cell cycle G2/M phase transition" EXACT [GOC:TermGenie] synonym: "downregulation of cell cycle G2/M phase transition" EXACT [GOC:TermGenie] synonym: "inhibition of cell cycle G2/M phase transition" NARROW [GOC:TermGenie] is_a: GO:1901988 ! negative regulation of cell cycle phase transition is_a: GO:1902749 ! regulation of cell cycle G2/M phase transition intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0044839 ! cell cycle G2/M phase transition relationship: negatively_regulates GO:0044839 ! cell cycle G2/M phase transition property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2014-03-05T15:38:21Z [Term] id: GO:1902765 name: L-arginine import into cell namespace: biological_process def: "The directed movement of L-arginine from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GO_REF:0000075, GOC:TermGenie, PMID:10617635] is_a: GO:0043091 ! L-arginine import is_a: GO:1902837 ! amino acid import into cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-03-10T10:26:31Z [Term] id: GO:1902806 name: regulation of cell cycle G1/S phase transition namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell cycle G1/S phase transition." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] is_a: GO:1901987 ! regulation of cell cycle phase transition intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0044843 ! cell cycle G1/S phase transition relationship: regulates GO:0044843 ! cell cycle G1/S phase transition property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2014-03-26T16:36:14Z [Term] id: GO:1902808 name: positive regulation of cell cycle G1/S phase transition namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell cycle G1/S phase transition." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie] synonym: "activation of cell cycle G1/S phase transition" NARROW [GOC:TermGenie] synonym: "up regulation of cell cycle G1/S phase transition" EXACT [GOC:TermGenie] synonym: "up-regulation of cell cycle G1/S phase transition" EXACT [GOC:TermGenie] synonym: "upregulation of cell cycle G1/S phase transition" EXACT [GOC:TermGenie] is_a: GO:1901989 ! positive regulation of cell cycle phase transition is_a: GO:1902806 ! regulation of cell cycle G1/S phase transition intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0044843 ! cell cycle G1/S phase transition relationship: positively_regulates GO:0044843 ! cell cycle G1/S phase transition property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2014-03-26T16:36:32Z [Term] id: GO:1902837 name: amino acid import into cell namespace: biological_process def: "The directed movement of amino acids from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GO_REF:0000075, GOC:TermGenie, PMID:24344203] is_a: GO:0043090 ! amino acid import is_a: GO:0098657 ! import into cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-04-01T13:44:26Z [Term] id: GO:1902850 name: microtubule cytoskeleton organization involved in mitosis namespace: biological_process def: "Any microtubule cytoskeleton organization that is involved in mitosis." [GO_REF:0000060, GOC:TermGenie, PMID:18799626] synonym: "microtubule cytoskeleton organisation involved in mitosis" EXACT [GOC:TermGenie] synonym: "microtubule cytoskeleton organization and biogenesis involved in mitosis" RELATED [GOC:TermGenie] synonym: "microtubule dynamics involved in mitosis" EXACT [GOC:TermGenie] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0000226 ! microtubule cytoskeleton organization intersection_of: part_of GO:0007067 ! mitotic nuclear division relationship: part_of GO:0007067 ! mitotic nuclear division property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: vw creation_date: 2014-04-02T14:19:38Z [Term] id: GO:1902861 name: copper ion import into cell namespace: biological_process def: "The directed movement of copper ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GO_REF:0000075, GOC:TermGenie, PMID:12244050] synonym: "copper cation import into cell" EXACT [CHEBI:23378] synonym: "copper import into cell" BROAD [GOC:mah] is_a: GO:0015677 ! copper ion import is_a: GO:0098659 ! inorganic cation import into cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-04-03T13:26:04Z [Term] id: GO:1902935 name: protein localization to septin ring namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a septin ring." [GO_REF:0000087, GOC:TermGenie, PMID:16325501] synonym: "protein localisation in septin ring" EXACT [GOC:TermGenie] synonym: "protein localisation to septin ring" EXACT [GOC:TermGenie] synonym: "protein localization in septin ring" EXACT [GOC:TermGenie] is_a: GO:0044380 ! protein localization to cytoskeleton is_a: GO:0072697 ! protein localization to cell cortex property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-04-25T13:08:17Z [Term] id: GO:1902967 name: protein localization to mitotic spindle midzone namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a mitotic spindle midzone." [GO_REF:0000087, GOC:TermGenie, PMID:16824200] synonym: "protein localisation in mitotic spindle midzone" EXACT [GOC:TermGenie] synonym: "protein localisation to mitotic spindle midzone" EXACT [GOC:TermGenie] synonym: "protein localization in mitotic spindle midzone" EXACT [GOC:TermGenie] is_a: GO:1902480 ! protein localization to mitotic spindle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-05-06T14:40:01Z [Term] id: GO:1902969 name: mitotic DNA replication namespace: biological_process def: "Any nuclear DNA replication that is involved in a mitotic cell cycle." [GO_REF:0000060, GOC:TermGenie] synonym: "DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "mitotic cell cycle DNA replication" EXACT [] synonym: "mitotic nuclear cell cycle DNA replication" EXACT [] synonym: "nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [] is_a: GO:0033260 ! nuclear DNA replication is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:0033260 ! nuclear DNA replication intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000278 ! mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2014-05-06T15:03:03Z [Term] id: GO:1902974 name: meiotic DNA replication initiation namespace: biological_process def: "Any DNA replication initiation involved in meiotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] synonym: "DNA replication initiation involved in meiotic cell cycle DNA replication" EXACT [] synonym: "DNA replication initiation involved in meiotic DNA replication" EXACT [] is_a: GO:1902315 ! nuclear cell cycle DNA replication initiation is_a: GO:1903046 ! meiotic cell cycle process intersection_of: GO:1902315 ! nuclear cell cycle DNA replication initiation intersection_of: part_of GO:0051321 ! meiotic cell cycle relationship: part_of GO:0051321 ! meiotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2014-05-06T15:21:06Z [Term] id: GO:1902975 name: mitotic DNA replication initiation namespace: biological_process def: "Any DNA replication initiation involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] synonym: "DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [] is_a: GO:1902315 ! nuclear cell cycle DNA replication initiation is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:1902315 ! nuclear cell cycle DNA replication initiation intersection_of: part_of GO:1902969 ! mitotic DNA replication relationship: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:1902969 ! mitotic DNA replication property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2014-05-06T15:21:11Z [Term] id: GO:1902983 name: DNA strand elongation involved in mitotic DNA replication namespace: biological_process def: "Any DNA strand elongation involved in mitotic cell cycle DNA replication." [GO_REF:0000060, GOC:TermGenie] synonym: "DNA strand elongation involved in mitotic cell cycle DNA replication" EXACT [] is_a: GO:1902319 ! DNA strand elongation involved in nuclear cell cycle DNA replication is_a: GO:1903047 ! mitotic cell cycle process intersection_of: GO:1902319 ! DNA strand elongation involved in nuclear cell cycle DNA replication intersection_of: part_of GO:1902969 ! mitotic DNA replication relationship: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:1902969 ! mitotic DNA replication property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2014-05-06T20:33:22Z [Term] id: GO:1903008 name: organelle disassembly namespace: biological_process def: "The disaggregation of an organelle into its constituent components." [GO_REF:0000079, GOC:TermGenie] synonym: "organelle degradation" EXACT [] is_a: GO:0022411 ! cellular component disassembly is_a: GO:1902589 ! single-organism organelle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2014-05-13T12:36:03Z [Term] id: GO:1903046 name: meiotic cell cycle process namespace: biological_process def: "A process that is part of the meiotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] is_a: GO:0022402 ! cell cycle process intersection_of: GO:0009987 ! cellular process intersection_of: part_of GO:0051321 ! meiotic cell cycle relationship: part_of GO:0051321 ! meiotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2014-05-22T14:22:28Z [Term] id: GO:1903047 name: mitotic cell cycle process namespace: biological_process def: "A process that is part of the mitotic cell cycle." [GO_REF:0000060, GOC:mtg_cell_cycle, GOC:TermGenie] is_a: GO:0022402 ! cell cycle process intersection_of: GO:0009987 ! cellular process intersection_of: part_of GO:0000278 ! mitotic cell cycle relationship: part_of GO:0000278 ! mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: jl creation_date: 2014-05-22T14:22:34Z [Term] id: GO:1903050 name: regulation of proteolysis involved in cellular protein catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of proteolysis involved in cellular protein catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834] comment: overexpression of cathepsin C propeptide significantly increased the degradation of of intestinal alkaline phosphatase (IAP) synonym: "regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] is_a: GO:0030162 ! regulation of proteolysis is_a: GO:1903362 ! regulation of cellular protein catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0051603 ! proteolysis involved in cellular protein catabolic process relationship: regulates GO:0051603 ! proteolysis involved in cellular protein catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rl creation_date: 2014-05-22T18:00:45Z [Term] id: GO:1903051 name: negative regulation of proteolysis involved in cellular protein catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in cellular protein catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834] comment: Overexpression of cathepsin C propeptide significantly increased the degradation of intestinal alkaline phosphatase (IAP). synonym: "down regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "down regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "down regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "down regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "down regulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "down-regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "down-regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "down-regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "down-regulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "downregulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "downregulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "downregulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "downregulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "inhibition of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "inhibition of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "inhibition of peptidolysis involved in cellular protein catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of peptidolysis involved in cellular protein catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "inhibition of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "inhibition of proteolysis involved in cellular protein catabolic process" NARROW [GOC:TermGenie] synonym: "negative regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "negative regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "negative regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "negative regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "negative regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] is_a: GO:0045861 ! negative regulation of proteolysis is_a: GO:1903050 ! regulation of proteolysis involved in cellular protein catabolic process is_a: GO:1903363 ! negative regulation of cellular protein catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0051603 ! proteolysis involved in cellular protein catabolic process relationship: negatively_regulates GO:0051603 ! proteolysis involved in cellular protein catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rl creation_date: 2014-05-22T18:00:51Z [Term] id: GO:1903052 name: positive regulation of proteolysis involved in cellular protein catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of proteolysis involved in cellular protein catabolic process." [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:18307834] comment: overexpression of cathepsin C propeptide significantly increased the degradation of of intestinal alkaline phosphatase (IAP) synonym: "activation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "activation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "activation of peptidolysis involved in cellular protein catabolic process" NARROW [GOC:TermGenie] synonym: "activation of peptidolysis involved in cellular protein catabolism" NARROW [GOC:TermGenie] synonym: "activation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "activation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "activation of proteolysis involved in cellular protein catabolic process" NARROW [GOC:TermGenie] synonym: "positive regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "positive regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "positive regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "positive regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "positive regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "up regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "up regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "up regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "up regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "up regulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "up-regulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "up-regulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "up-regulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "up-regulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of peptidolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "upregulation of peptidolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "upregulation of peptidolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of peptidolysis involved in cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of proteolysis during cellular protein catabolic process" RELATED [GOC:TermGenie] synonym: "upregulation of proteolysis during cellular protein catabolism" RELATED [GOC:TermGenie] synonym: "upregulation of proteolysis involved in cellular protein catabolic process" EXACT [GOC:TermGenie] is_a: GO:0045862 ! positive regulation of proteolysis is_a: GO:1903050 ! regulation of proteolysis involved in cellular protein catabolic process is_a: GO:1903364 ! positive regulation of cellular protein catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0051603 ! proteolysis involved in cellular protein catabolic process relationship: positively_regulates GO:0051603 ! proteolysis involved in cellular protein catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: rl creation_date: 2014-05-22T18:00:57Z [Term] id: GO:1903075 name: pyridoxine import into cell namespace: biological_process def: "The directed movement of pyridoxine from outside of a cell into the intracellular region of a cell." [GO_REF:0000075, GOC:TermGenie, PMID:15701794] is_a: GO:0031923 ! pyridoxine transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-05-29T15:04:14Z [Term] id: GO:1903083 name: protein localization to condensed chromosome namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a condensed chromosome." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, pmid:12707312] synonym: "protein localisation in condensed chromosome" EXACT [GOC:TermGenie] synonym: "protein localisation to condensed chromosome" EXACT [GOC:TermGenie] synonym: "protein localization in condensed chromosome" EXACT [GOC:TermGenie] is_a: GO:0034502 ! protein localization to chromosome property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: kmv creation_date: 2014-05-29T20:31:25Z [Term] id: GO:1903084 name: protein localization to condensed nuclear chromosome namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a condensed nuclear chromosome." [GO_REF:0000087, GOC:kmv, GOC:TermGenie, pmid:12707312] synonym: "protein localisation in condensed nuclear chromosome" EXACT [GOC:TermGenie] synonym: "protein localisation to condensed nuclear chromosome" EXACT [GOC:TermGenie] synonym: "protein localization in condensed nuclear chromosome" EXACT [GOC:TermGenie] is_a: GO:0034504 ! protein localization to nucleus is_a: GO:1903083 ! protein localization to condensed chromosome property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: kmv creation_date: 2014-05-29T20:33:17Z [Term] id: GO:1903119 name: protein localization to actin cytoskeleton namespace: biological_process def: "A process in which a protein is transported to, or maintained in, the location of an actin cytoskeleton." [GO_REF:0000087, GOC:TermGenie, PMID:24798735] synonym: "protein localisation in actin cytoskeleton" EXACT [GOC:TermGenie] synonym: "protein localisation to actin cytoskeleton" EXACT [GOC:TermGenie] synonym: "protein localization in actin cytoskeleton" EXACT [GOC:TermGenie] is_a: GO:0044380 ! protein localization to cytoskeleton property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-06-16T11:27:09Z [Term] id: GO:1903120 name: protein localization to actin filament bundle namespace: biological_process def: "A process in which a protein is transported to, or maintained in, the location of an actin filament bundle." [GO_REF:0000087, GOC:TermGenie, PMID:24798735] synonym: "protein localisation in actin filament bundle" EXACT [GOC:TermGenie] synonym: "protein localisation to actin filament bundle" EXACT [GOC:TermGenie] synonym: "protein localization in actin filament bundle" EXACT [GOC:TermGenie] synonym: "protein localization to actin cable" RELATED [GOC:mah] is_a: GO:1903119 ! protein localization to actin cytoskeleton property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-06-16T11:27:16Z [Term] id: GO:1903212 name: protein localization to mating-type region heterochromatin namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a mating-type region heterochromatin." [GO_REF:0000087, GOC:TermGenie, PMID:18761674] synonym: "protein localisation in mating-type region heterochromatin" EXACT [GOC:TermGenie] synonym: "protein localisation to mating-type region heterochromatin" EXACT [GOC:TermGenie] synonym: "protein localization in mating-type region heterochromatin" EXACT [GOC:TermGenie] is_a: GO:0097355 ! protein localization to heterochromatin property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-07-24T09:38:12Z [Term] id: GO:1903213 name: protein localization to subtelomeric heterochromatin namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a subtelomeric heterochromatin." [GO_REF:0000087, GOC:TermGenie, SO:0001997] synonym: "protein localisation in subtelomeric heterochromatin" EXACT [GOC:TermGenie] synonym: "protein localisation to subtelomeric heterochromatin" EXACT [GOC:TermGenie] synonym: "protein localization in subtelomeric heterochromatin" EXACT [GOC:TermGenie] is_a: GO:0097355 ! protein localization to heterochromatin property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-07-24T09:38:18Z [Term] id: GO:1903241 name: U2-type prespliceosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an U2-type prespliceosome." [GO_REF:0000079, GOC:TermGenie, PMID:12374752] synonym: "GT-AG prespliceosome assembly" NARROW [GOC:TermGenie] synonym: "GT-AG prespliceosome formation" NARROW [GOC:TermGenie] synonym: "major prespliceosome assembly" EXACT [GOC:TermGenie] synonym: "major prespliceosome formation" EXACT [GOC:TermGenie] synonym: "mammalian U2-type spliceosomal complex A assembly" NARROW [GOC:TermGenie] synonym: "mammalian U2-type spliceosomal complex A formation" NARROW [GOC:TermGenie] synonym: "U2-type prespliceosome formation" EXACT [GOC:TermGenie] synonym: "yeast U2-type spliceosomal complex B assembly" NARROW [GOC:TermGenie] synonym: "yeast U2-type spliceosomal complex B formation" NARROW [GOC:TermGenie] is_a: GO:0000245 ! spliceosomal complex assembly property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-08-01T14:33:45Z [Term] id: GO:1903258 name: sorbose import into cell namespace: biological_process def: "The directed movement of sorbose into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:2878925] is_a: GO:0008645 ! hexose transport property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-08-06T09:21:53Z [Term] id: GO:1903260 name: protein localization to mating projection tip namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a mating projection tip." [GO_REF:0000087, GOC:TermGenie, PMID:11952834] synonym: "protein localisation in mating projection tip" EXACT [GOC:TermGenie] synonym: "protein localisation to mating projection tip" EXACT [GOC:TermGenie] synonym: "protein localization in mating projection tip" EXACT [GOC:TermGenie] synonym: "protein localization to conjugation tube tip" NARROW [] synonym: "protein localization to shmoo tip" NARROW [] is_a: GO:0008104 ! protein localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-08-06T13:26:14Z [Term] id: GO:1903292 name: protein localization to Golgi membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a Golgi membrane." [GO_REF:0000087, GOC:TermGenie, PMID:11378902] synonym: "protein localisation in Golgi membrane" EXACT [GOC:TermGenie] synonym: "protein localisation to Golgi membrane" EXACT [GOC:TermGenie] synonym: "protein localization in Golgi membrane" EXACT [GOC:TermGenie] is_a: GO:0034067 ! protein localization to Golgi apparatus is_a: GO:0072657 ! protein localization to membrane property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-08-12T14:22:31Z [Term] id: GO:1903320 name: regulation of protein modification by small protein conjugation or removal namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw] is_a: GO:0031399 ! regulation of protein modification process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0070647 ! protein modification by small protein conjugation or removal relationship: regulates GO:0070647 ! protein modification by small protein conjugation or removal property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: vw creation_date: 2014-08-18T13:01:00Z [Term] id: GO:1903321 name: negative regulation of protein modification by small protein conjugation or removal namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein modification by small protein conjugation or removal." [GO_REF:0000058, GOC:TermGenie, GOC:vw] synonym: "down regulation of protein modification by small protein conjugation or removal" EXACT [GOC:TermGenie] synonym: "down-regulation of protein modification by small protein conjugation or removal" EXACT [GOC:TermGenie] synonym: "downregulation of protein modification by small protein conjugation or removal" EXACT [GOC:TermGenie] synonym: "inhibition of protein modification by small protein conjugation or removal" NARROW [GOC:TermGenie] is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0070647 ! protein modification by small protein conjugation or removal relationship: negatively_regulates GO:0070647 ! protein modification by small protein conjugation or removal property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: vw creation_date: 2014-08-18T13:01:08Z [Term] id: GO:1903360 name: protein localization to lateral cortical node namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a lateral cortical node." [GO_REF:0000087, GOC:TermGenie, PMID:25009287] synonym: "protein localisation in lateral cortical node" EXACT [GOC:TermGenie] synonym: "protein localisation to lateral cortical node" EXACT [GOC:TermGenie] synonym: "protein localization in lateral cortical node" EXACT [GOC:TermGenie] is_a: GO:0072697 ! protein localization to cell cortex property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-08-21T10:23:00Z [Term] id: GO:1903362 name: regulation of cellular protein catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:24785082] synonym: "regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "regulation of cellular protein degradation" EXACT [GOC:TermGenie] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0032268 ! regulation of cellular protein metabolic process is_a: GO:0042176 ! regulation of protein catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0044257 ! cellular protein catabolic process relationship: regulates GO:0044257 ! cellular protein catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: kmv creation_date: 2014-08-21T15:05:45Z [Term] id: GO:1903363 name: negative regulation of cellular protein catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cellular protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:24785082] synonym: "down regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "down regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "down-regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "downregulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "inhibition of cellular protein breakdown" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein catabolic process" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein catabolism" NARROW [GOC:TermGenie] synonym: "inhibition of cellular protein degradation" NARROW [GOC:TermGenie] synonym: "negative regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "negative regulation of cellular protein degradation" EXACT [GOC:TermGenie] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0032269 ! negative regulation of cellular protein metabolic process is_a: GO:0042177 ! negative regulation of protein catabolic process is_a: GO:1903362 ! regulation of cellular protein catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0044257 ! cellular protein catabolic process relationship: negatively_regulates GO:0044257 ! cellular protein catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: kmv creation_date: 2014-08-21T15:05:53Z [Term] id: GO:1903364 name: positive regulation of cellular protein catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular protein catabolic process." [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:24785082] synonym: "activation of cellular protein breakdown" NARROW [GOC:TermGenie] synonym: "activation of cellular protein catabolic process" NARROW [GOC:TermGenie] synonym: "activation of cellular protein catabolism" NARROW [GOC:TermGenie] synonym: "activation of cellular protein degradation" NARROW [GOC:TermGenie] synonym: "positive regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "positive regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "up regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "up-regulation of cellular protein degradation" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein breakdown" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein catabolic process" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein catabolism" EXACT [GOC:TermGenie] synonym: "upregulation of cellular protein degradation" EXACT [GOC:TermGenie] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0032270 ! positive regulation of cellular protein metabolic process is_a: GO:0045732 ! positive regulation of protein catabolic process is_a: GO:1903362 ! regulation of cellular protein catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0044257 ! cellular protein catabolic process relationship: positively_regulates GO:0044257 ! cellular protein catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: kmv creation_date: 2014-08-21T15:06:01Z [Term] id: GO:1903398 name: regulation of m7G(5')pppN diphosphatase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of m7G(5')pppN diphosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:22323607] synonym: "regulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "regulation of decapase activity" RELATED [GOC:TermGenie] synonym: "regulation of M(7)G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie] synonym: "regulation of m7G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie] is_a: GO:0051336 ! regulation of hydrolase activity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0050072 ! m7G(5')pppN diphosphatase activity relationship: regulates GO:0050072 ! m7G(5')pppN diphosphatase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-09-01T10:16:40Z [Term] id: GO:1903399 name: positive regulation of m7G(5')pppN diphosphatase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of m7G(5')pppN diphosphatase activity." [GO_REF:0000059, GOC:TermGenie, PMID:22323607] synonym: "activation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" NARROW [GOC:TermGenie] synonym: "activation of decapase activity" RELATED [GOC:TermGenie] synonym: "activation of M(7)G(5')pppN pyrophosphatase activity" NARROW [GOC:TermGenie] synonym: "activation of m7G(5')pppN diphosphatase activity" NARROW [GOC:TermGenie] synonym: "activation of m7G(5')pppN pyrophosphatase activity" NARROW [GOC:TermGenie] synonym: "positive regulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of decapase activity" RELATED [GOC:TermGenie] synonym: "positive regulation of M(7)G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie] synonym: "positive regulation of m7G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "up regulation of decapase activity" RELATED [GOC:TermGenie] synonym: "up regulation of M(7)G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of m7G(5')pppN diphosphatase activity" EXACT [GOC:TermGenie] synonym: "up regulation of m7G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of decapase activity" RELATED [GOC:TermGenie] synonym: "up-regulation of M(7)G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of m7G(5')pppN diphosphatase activity" EXACT [GOC:TermGenie] synonym: "up-regulation of m7G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of 7-methylguanosine-5'-triphospho-5'-polynucleotide 7-methylguanosine-5'-phosphohydrolase activity" EXACT [GOC:TermGenie] synonym: "upregulation of decapase activity" RELATED [GOC:TermGenie] synonym: "upregulation of M(7)G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of m7G(5')pppN diphosphatase activity" EXACT [GOC:TermGenie] synonym: "upregulation of m7G(5')pppN pyrophosphatase activity" EXACT [GOC:TermGenie] is_a: GO:0051345 ! positive regulation of hydrolase activity is_a: GO:1903398 ! regulation of m7G(5')pppN diphosphatase activity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0050072 ! m7G(5')pppN diphosphatase activity relationship: positively_regulates GO:0050072 ! m7G(5')pppN diphosphatase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-09-01T10:16:49Z [Term] id: GO:1903405 name: protein localization to nuclear body namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a nuclear body." [GO_REF:0000087, GOC:TermGenie, PMID:24713849] synonym: "protein localisation in nuclear body" EXACT [GOC:TermGenie] synonym: "protein localisation to nuclear body" EXACT [GOC:TermGenie] synonym: "protein localization in nuclear body" EXACT [GOC:TermGenie] is_a: GO:1990173 ! protein localization to nucleoplasm property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-09-01T13:57:11Z [Term] id: GO:1903410 name: L-lysine import into cell namespace: biological_process def: "The directed movement of L-lysine into a cell." [GO_REF:0000075, GOC:krc, GOC:TermGenie, PMID:8195186] is_a: GO:0061461 ! L-lysine import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: pr creation_date: 2014-09-03T09:32:57Z [Term] id: GO:1903418 name: protein localization to plasma membrane of cell tip namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a plasma membrane of cell tip." [GO_REF:0000087, GOC:TermGenie, PMID:25157670] synonym: "protein localisation in plasma membrane of cell tip" EXACT [GOC:TermGenie] synonym: "protein localisation to plasma membrane of cell tip" EXACT [GOC:TermGenie] synonym: "protein localization in plasma membrane of cell tip" EXACT [GOC:TermGenie] is_a: GO:0072659 ! protein localization to plasma membrane is_a: GO:1990151 ! protein localization to cell tip property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-09-08T15:08:51Z [Term] id: GO:1903420 name: protein localization to endoplasmic reticulum tubular network namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within an endoplasmic reticulum tubular network." [GO_REF:0000087, GOC:TermGenie, PMID:25103238] synonym: "protein localisation in endoplasmic reticulum tubular network" EXACT [GOC:TermGenie] synonym: "protein localisation to endoplasmic reticulum tubular network" EXACT [GOC:TermGenie] synonym: "protein localization in endoplasmic reticulum tubular network" EXACT [GOC:TermGenie] synonym: "protein localization to tubular ER" RELATED [PMID:25103238] is_a: GO:0070972 ! protein localization to endoplasmic reticulum property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-09-08T16:03:37Z [Term] id: GO:1903463 name: regulation of mitotic cell cycle DNA replication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic cell cycle DNA replication." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] synonym: "regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0033262 ! regulation of nuclear cell cycle DNA replication intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:1902969 ! mitotic DNA replication relationship: regulates GO:1902969 ! mitotic DNA replication property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: vw creation_date: 2014-09-23T13:38:25Z [Term] id: GO:1903464 name: negative regulation of mitotic cell cycle DNA replication namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle DNA replication." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] synonym: "down regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "down regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "down regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "down regulation of mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "down regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "down regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "down-regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "down-regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "down-regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "down-regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "downregulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "downregulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "downregulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "downregulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "downregulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "inhibition of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "inhibition of DNA replication involved in S phase involved in mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "inhibition of DNA replication involved in S-phase involved in mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "inhibition of mitotic cell cycle DNA replication" NARROW [GOC:TermGenie] synonym: "inhibition of mitotic nuclear cell cycle DNA replication" NARROW [GOC:TermGenie] synonym: "inhibition of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "negative regulation of DNA replication during S phase involved in mitotic cell cycle" RELATED [GOC:TermGenie] synonym: "negative regulation of DNA replication involved in S phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "negative regulation of DNA replication involved in S-phase involved in mitotic cell cycle" EXACT [GOC:TermGenie] synonym: "negative regulation of mitotic nuclear cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "negative regulation of nuclear cell cycle DNA replication involved in mitotic cell cycle" RELATED [GOC:TermGenie] is_a: GO:0045930 ! negative regulation of mitotic cell cycle is_a: GO:1902576 ! negative regulation of nuclear cell cycle DNA replication is_a: GO:1903463 ! regulation of mitotic cell cycle DNA replication intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:1902969 ! mitotic DNA replication relationship: negatively_regulates GO:1902969 ! mitotic DNA replication property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: vw creation_date: 2014-09-23T13:38:33Z [Term] id: GO:1903466 name: regulation of mitotic DNA replication initiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA replication initiation involved in mitotic DNA replication." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] synonym: "regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] is_a: GO:0030174 ! regulation of DNA-dependent DNA replication initiation is_a: GO:1903463 ! regulation of mitotic cell cycle DNA replication intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:1902975 ! mitotic DNA replication initiation relationship: regulates GO:1902975 ! mitotic DNA replication initiation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: vw creation_date: 2014-09-23T13:38:49Z [Term] id: GO:1903467 name: negative regulation of mitotic DNA replication initiation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication initiation involved in mitotic DNA replication." [GO_REF:0000058, GOC:mtg_cell_cycle, GOC:TermGenie, PMID:1234] synonym: "down regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "down regulation of DNA replication initiation involved in mitotic DNA replication" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "down-regulation of DNA replication initiation involved in mitotic DNA replication" EXACT [GOC:TermGenie] synonym: "downregulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] synonym: "downregulation of DNA replication initiation involved in mitotic DNA replication" EXACT [GOC:TermGenie] synonym: "inhibition of DNA replication initiation involved in mitotic cell cycle DNA replication" NARROW [GOC:TermGenie] synonym: "inhibition of DNA replication initiation involved in mitotic DNA replication" NARROW [GOC:TermGenie] synonym: "negative regulation of DNA replication initiation involved in mitotic cell cycle DNA replication" EXACT [GOC:TermGenie] is_a: GO:0032297 ! negative regulation of DNA-dependent DNA replication initiation is_a: GO:1903464 ! negative regulation of mitotic cell cycle DNA replication is_a: GO:1903466 ! regulation of mitotic DNA replication initiation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:1902975 ! mitotic DNA replication initiation relationship: negatively_regulates GO:1902975 ! mitotic DNA replication initiation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: vw creation_date: 2014-09-23T13:38:58Z [Term] id: GO:1903504 name: regulation of mitotic spindle checkpoint namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic spindle checkpoint." [GO_REF:0000058, GOC:TermGenie, PMID:23442800] comment: Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of spindle checkpoint (assembly, orientation or Dma1-dependent). subset: gocheck_do_not_manually_annotate synonym: "regulation of mitotic cell cycle spindle checkpoint" EXACT [GOC:TermGenie] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0090231 ! regulation of spindle checkpoint intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0071174 ! mitotic spindle checkpoint relationship: regulates GO:0071174 ! mitotic spindle checkpoint property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: al creation_date: 2014-10-01T13:52:57Z [Term] id: GO:1903506 name: regulation of nucleic acid-templated transcription namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nucleic acid-templated transcription." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:txnOH, GOC:vw] is_a: GO:2001141 ! regulation of RNA biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0097659 ! nucleic acid-templated transcription relationship: regulates GO:0097659 ! nucleic acid-templated transcription property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: pr creation_date: 2014-10-01T14:44:47Z [Term] id: GO:1903507 name: negative regulation of nucleic acid-templated transcription namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of nucleic acid-templated transcription." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:txnOH, GOC:vw] synonym: "down regulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie] synonym: "down-regulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie] synonym: "downregulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie] synonym: "inhibition of nucleic acid-templated transcription" NARROW [GOC:TermGenie] is_a: GO:1902679 ! negative regulation of RNA biosynthetic process is_a: GO:1903506 ! regulation of nucleic acid-templated transcription intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0097659 ! nucleic acid-templated transcription relationship: negatively_regulates GO:0097659 ! nucleic acid-templated transcription property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: pr creation_date: 2014-10-01T14:44:56Z [Term] id: GO:1903508 name: positive regulation of nucleic acid-templated transcription namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nucleic acid-templated transcription." [GO_REF:0000058, GOC:pr, GOC:TermGenie, GOC:txnOH, GOC:vw] synonym: "activation of nucleic acid-templated transcription" NARROW [GOC:TermGenie] synonym: "up regulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie] synonym: "up-regulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie] synonym: "upregulation of nucleic acid-templated transcription" EXACT [GOC:TermGenie] is_a: GO:1902680 ! positive regulation of RNA biosynthetic process is_a: GO:1903506 ! regulation of nucleic acid-templated transcription intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0097659 ! nucleic acid-templated transcription relationship: positively_regulates GO:0097659 ! nucleic acid-templated transcription property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: pr creation_date: 2014-10-01T14:45:04Z [Term] id: GO:1903608 name: protein localization to cytoplasmic stress granule namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a cytoplasmic stress granule." [GO_REF:0000087, GOC:TermGenie, PMID:24755092] synonym: "protein localisation in cytoplasmic stress granule" EXACT [GOC:TermGenie] synonym: "protein localisation to cytoplasmic stress granule" EXACT [GOC:TermGenie] synonym: "protein localization in cytoplasmic stress granule" EXACT [GOC:TermGenie] synonym: "protein localization to stress granule" BROAD [] is_a: GO:0033365 ! protein localization to organelle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-11-14T16:20:32Z [Term] id: GO:1903692 name: methionine import into cell namespace: biological_process def: "The directed movement of methionine into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:17556368] is_a: GO:0044690 ! methionine import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-12-02T10:53:28Z [Term] id: GO:1903696 name: protein localization to horsetail-astral microtubule array namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a horsetail-astral microtubule array." [GO_REF:0000087, GOC:TermGenie, PMID:11907273] synonym: "protein localisation in horsetail-astral microtubule array" EXACT [GOC:TermGenie] synonym: "protein localisation to horsetail-astral microtubule array" EXACT [GOC:TermGenie] synonym: "protein localization in horsetail-astral microtubule array" EXACT [GOC:TermGenie] is_a: GO:0072699 ! protein localization to cortical microtubule cytoskeleton property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-12-03T10:58:18Z [Term] id: GO:1903778 name: protein localization to vacuolar membrane namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within a vacuolar membrane." [GO_REF:0000087, GOC:TermGenie, PMID:25378562] synonym: "protein localisation in vacuolar membrane" EXACT [GOC:TermGenie] synonym: "protein localisation to vacuolar membrane" EXACT [GOC:TermGenie] synonym: "protein localization in vacuolar membrane" EXACT [GOC:TermGenie] is_a: GO:0072657 ! protein localization to membrane is_a: GO:0072665 ! protein localization to vacuole property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2015-01-07T13:15:54Z [Term] id: GO:1903801 name: L-leucine import into cell namespace: biological_process def: "The directed movement of L-leucine into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] is_a: GO:0043092 ! L-amino acid import is_a: GO:0060356 ! leucine import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2015-01-16T14:34:46Z [Term] id: GO:1903802 name: L-glutamate(1-) import into cell namespace: biological_process def: "The directed movement of L-glutamate(1-) into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] is_a: GO:0051938 ! L-glutamate import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2015-01-16T14:34:56Z [Term] id: GO:1903803 name: L-glutamine import into cell namespace: biological_process def: "The directed movement of L-glutamine into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] is_a: GO:0036229 ! L-glutamine import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2015-01-16T14:35:05Z [Term] id: GO:1903804 name: glycine import into cell namespace: biological_process def: "The directed movement of glycine into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] is_a: GO:0036233 ! glycine import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2015-01-16T14:35:14Z [Term] id: GO:1903805 name: L-valine import into cell namespace: biological_process def: "The directed movement of L-valine into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] is_a: GO:0043092 ! L-amino acid import is_a: GO:0090468 ! valine import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2015-01-16T14:35:23Z [Term] id: GO:1903806 name: L-isoleucine import into cell namespace: biological_process def: "The directed movement of L-isoleucine into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] is_a: GO:0090477 ! L-isoleucine import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2015-01-16T14:35:33Z [Term] id: GO:1903807 name: L-threonine import into cell namespace: biological_process def: "The directed movement of L-threonine into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] is_a: GO:0036231 ! L-threonine import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2015-01-16T14:35:42Z [Term] id: GO:1903808 name: L-tyrosine import into cell namespace: biological_process def: "The directed movement of L-tyrosine into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] is_a: GO:0036232 ! L-tyrosine import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2015-01-16T14:35:51Z [Term] id: GO:1903809 name: L-proline import into cell namespace: biological_process def: "The directed movement of L-proline into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] is_a: GO:0015824 ! proline transport is_a: GO:0043092 ! L-amino acid import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2015-01-16T14:36:01Z [Term] id: GO:1903810 name: L-histidine import into cell namespace: biological_process def: "The directed movement of L-histidine into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] is_a: GO:0061460 ! L-histidine import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2015-01-16T14:36:10Z [Term] id: GO:1903811 name: L-asparagine import into cell namespace: biological_process def: "The directed movement of L-asparagine into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] is_a: GO:0043092 ! L-amino acid import is_a: GO:0090469 ! asparagine import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2015-01-16T14:36:19Z [Term] id: GO:1903812 name: L-serine import into cell namespace: biological_process def: "The directed movement of L-serine into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] is_a: GO:0090479 ! L-serine import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2015-01-16T14:36:29Z [Term] id: GO:1903813 name: L-methionine import into cell namespace: biological_process def: "The directed movement of L-methionine into a cell." [GO_REF:0000075, GOC:TermGenie, PMID:23895341] is_a: GO:0043092 ! L-amino acid import is_a: GO:1903692 ! methionine import into cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2015-01-16T15:03:17Z [Term] id: GO:1903858 name: protein localization to old growing cell tip namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within an old growing cell tip." [GO_REF:0000087, GOC:TermGenie, PMID:17895368] synonym: "protein localisation in old growing cell tip" EXACT [GOC:TermGenie] synonym: "protein localisation to old growing cell tip" EXACT [GOC:TermGenie] synonym: "protein localization in old growing cell tip" EXACT [GOC:TermGenie] is_a: GO:1902486 ! protein localization to growing cell tip property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2015-02-02T13:53:29Z [Term] id: GO:1904185 name: equatorial microtubule organizing center assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an equatorial microtubule organizing center." [GO_REF:0000079, GOC:TermGenie, PMID:15004232] synonym: "EMTOC assembly" EXACT [GOC:TermGenie] synonym: "EMTOC formation" EXACT [GOC:TermGenie] synonym: "equatorial microtubule organising centre assembly" EXACT [GOC:TermGenie] synonym: "equatorial microtubule organising centre formation" EXACT [GOC:TermGenie] synonym: "equatorial microtubule organizing center formation" EXACT [GOC:TermGenie] is_a: GO:0022607 ! cellular component assembly is_a: GO:0031023 ! microtubule organizing center organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2015-05-05T14:24:30Z [Term] id: GO:1904186 name: post-anaphase microtubule array organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly ofa post-anaphase microtubule array." [GO_REF:000103, GOC:TermGenie, PMID:15004232] synonym: "PAA organization" EXACT [GOC:TermGenie] synonym: "post-anaphase array organization" EXACT [GOC:TermGenie] synonym: "post-anaphase microtubule array organisation" EXACT [] is_a: GO:0016043 ! cellular component organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2015-05-05T14:40:16Z [Term] id: GO:1904497 name: heterochromatin assembly involved in chromatin silencing at centromere outer repeat region namespace: biological_process def: "Any heterochromatin assembly that is involved in chromatin silencing at the centromere outer repeat region." [GO_REF:0000060, GOC:TermGenie, PMID:24240238] synonym: "establishment of heterochromatin architecture involved in chromatin silencing at centromere outer repeat region" EXACT [GOC:TermGenie] synonym: "establishment of heterochromatin architecture involved in chromatin silencing at pericentric region" RELATED [GOC:TermGenie] synonym: "heterochromatin assembly involved in chromatin silencing at pericentric region" RELATED [GOC:TermGenie] synonym: "heterochromatin formation involved in chromatin silencing at centromere outer repeat region" EXACT [GOC:TermGenie] synonym: "heterochromatin formation involved in chromatin silencing at pericentric region" RELATED [GOC:TermGenie] is_a: GO:0070869 ! heterochromatin assembly involved in chromatin silencing intersection_of: GO:0031507 ! heterochromatin assembly intersection_of: part_of GO:1990141 ! chromatin silencing at centromere outer repeat region relationship: part_of GO:1990141 ! chromatin silencing at centromere outer repeat region property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2015-07-22T14:25:43Z [Term] id: GO:1904498 name: protein localization to actomyosin contractile ring involved in mitotic cytokinesis namespace: biological_process def: "Any protein localization to actomyosin contractile ring that is involved in mitotic cytokinesis." [GO_REF:0000060, GOC:TermGenie, PMID:25688133] synonym: "protein localisation to actomyosin contractile ring involved in cytokinesis after mitosis" EXACT [GOC:TermGenie] synonym: "protein localisation to actomyosin contractile ring involved in mitotic cytokinesis" EXACT [GOC:TermGenie] synonym: "protein localisation to mitotic actomyosin contractile ring" EXACT [] synonym: "protein localization to actomyosin contractile ring during mitotic cytokinesis" RELATED [] synonym: "protein localization to actomyosin contractile ring involved in cytokinesis after mitosis" EXACT [GOC:TermGenie] synonym: "protein localization to mitotic actomyosin contractile ring" EXACT [] is_a: GO:1990179 ! protein localization to actomyosin contractile ring intersection_of: GO:1990179 ! protein localization to actomyosin contractile ring intersection_of: part_of GO:0000281 ! mitotic cytokinesis relationship: part_of GO:0000281 ! mitotic cytokinesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2015-07-22T14:30:57Z [Term] id: GO:1904512 name: regulation of initiation of premeiotic DNA replication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of initiation of premeiotic DNA replication." [GO_REF:0000058, GOC:TermGenie, PMID:25891897] synonym: "regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie] synonym: "regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie] is_a: GO:0030174 ! regulation of DNA-dependent DNA replication initiation is_a: GO:0033262 ! regulation of nuclear cell cycle DNA replication is_a: GO:0051445 ! regulation of meiotic cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0072691 ! initiation of premeiotic DNA replication relationship: regulates GO:0072691 ! initiation of premeiotic DNA replication property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2015-07-28T12:59:17Z [Term] id: GO:1904513 name: negative regulation of initiation of premeiotic DNA replication namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of initiation of premeiotic DNA replication." [GO_REF:0000058, GOC:TermGenie, PMID:25891897] synonym: "down regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "down regulation of initiation of premeiotic DNA replication" EXACT [GOC:TermGenie] synonym: "down regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "down regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie] synonym: "down regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie] synonym: "down-regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "down-regulation of initiation of premeiotic DNA replication" EXACT [GOC:TermGenie] synonym: "down-regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "down-regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie] synonym: "down-regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie] synonym: "downregulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "downregulation of initiation of premeiotic DNA replication" EXACT [GOC:TermGenie] synonym: "downregulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "downregulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie] synonym: "downregulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie] synonym: "inhibition of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "inhibition of initiation of premeiotic DNA replication" NARROW [GOC:TermGenie] synonym: "inhibition of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "inhibition of meiotic DNA replication initiation" RELATED [GOC:TermGenie] synonym: "inhibition of premeiotic DNA replication initiation" NARROW [GOC:TermGenie] synonym: "negative regulation of initiation of meiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "negative regulation of initiation of premeiotic DNA synthesis" RELATED [GOC:TermGenie] synonym: "negative regulation of meiotic DNA replication initiation" RELATED [GOC:TermGenie] synonym: "negative regulation of premeiotic DNA replication initiation" EXACT [GOC:TermGenie] is_a: GO:0032297 ! negative regulation of DNA-dependent DNA replication initiation is_a: GO:0051447 ! negative regulation of meiotic cell cycle is_a: GO:1902576 ! negative regulation of nuclear cell cycle DNA replication is_a: GO:1904512 ! regulation of initiation of premeiotic DNA replication intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0072691 ! initiation of premeiotic DNA replication relationship: negatively_regulates GO:0072691 ! initiation of premeiotic DNA replication property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2015-07-28T12:59:23Z [Term] id: GO:1904518 name: protein localization to cytoplasmic microtubule plus-end namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location at a cytoplasmic microtubule plus-end." [GO_REF:0000087, GOC:TermGenie, PMID:15772152] synonym: "protein localisation in cytoplasmic microtubule plus-end" EXACT [GOC:TermGenie] synonym: "protein localisation to cytoplasmic microtubule plus-end" EXACT [GOC:TermGenie] synonym: "protein localization in cytoplasmic microtubule plus-end" EXACT [GOC:TermGenie] is_a: GO:0035372 ! protein localization to microtubule property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2015-07-29T14:46:05Z [Term] id: GO:1904519 name: protein localization to microtubule minus-end namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location at a microtubule minus-end." [GO_REF:0000087, GOC:TermGenie, PMID:25987607] synonym: "protein localisation in microtubule minus-end" EXACT [GOC:TermGenie] synonym: "protein localisation to microtubule minus-end" EXACT [GOC:TermGenie] synonym: "protein localization in microtubule minus-end" EXACT [GOC:TermGenie] is_a: GO:0035372 ! protein localization to microtubule property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2015-07-29T14:46:11Z [Term] id: GO:1990023 name: mitotic spindle midzone namespace: cellular_component def: "The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner." [GOC:mtg_cell_cycle, GOC:vw] is_a: GO:0051233 ! spindle midzone relationship: part_of GO:0072686 ! mitotic spindle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: vw creation_date: 2013-02-05T15:41:48Z [Term] id: GO:1990034 name: calcium ion export from cell namespace: biological_process def: "The directed movement of calcium ions out of a cell." [GOC:mah, PMID:2145281] synonym: "calcium ion efflux from cell" EXACT [GOC:vw, PMID:2145281] is_a: GO:1901660 ! calcium ion export property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2013-02-07T13:01:29Z [Term] id: GO:1990035 name: calcium ion import into cell namespace: biological_process def: "The directed movement of calcium ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:mah, PMID:2145281] synonym: "calcium ion uptake into cell" EXACT [GOC:vw] is_a: GO:0070509 ! calcium ion import is_a: GO:0098659 ! inorganic cation import into cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2013-02-07T13:07:59Z [Term] id: GO:1990043 name: 5' deoxyribonuclease (pyrimidine dimer) activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage immediately 5' to pyrimidine dimers to products with 5'-phosphate." [EC:3.1.25.-, GOC:al, PMID:9708997] is_a: GO:0033892 ! deoxyribonuclease (pyrimidine dimer) activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: pr creation_date: 2013-02-15T12:16:51Z [Term] id: GO:1990074 name: polyuridylation-dependent mRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of uridylyl residues (polyuridylation) at the 3' end of the target mRNA." [GOC:vw, PMID:23503588] is_a: GO:0006402 ! mRNA catabolic process is_a: GO:0043632 ! modification-dependent macromolecule catabolic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tb creation_date: 2013-04-16T22:51:46Z [Term] id: GO:1990118 name: sodium ion import into cell namespace: biological_process def: "The directed movement of sodium ions from outside of a cell into the intracellular region of a cell." [GOC:al, PMID:14674689] is_a: GO:0097369 ! sodium ion import property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: pr creation_date: 2013-06-09T07:21:26Z [Term] id: GO:1990123 name: L-glutamate import into cell namespace: biological_process def: "The directed movement of L-glutamate from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:mah, PMID:1356078] is_a: GO:1902837 ! amino acid import into cell is_a: GO:1903802 ! L-glutamate(1-) import into cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2013-06-12T12:32:47Z [Term] id: GO:1990139 name: protein localization to nuclear periphery namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within the nuclear periphery." [GOC:mah, PMID:23703609] is_a: GO:0034504 ! protein localization to nucleus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2013-07-09T13:35:49Z [Term] id: GO:1990141 name: chromatin silencing at centromere outer repeat region namespace: biological_process def: "Repression of transcription of DNA at the outer repeat region of a regional centromere by altering the structure of chromatin." [PMID:21847092] synonym: "chromatin silencing at pericentric region" RELATED [GOC:mah] is_a: GO:0030702 ! chromatin silencing at centromere property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2013-07-17T15:21:38Z [Term] id: GO:1990151 name: protein localization to cell tip namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location at the cell tip." [PMID:22768263] synonym: "protein localisation to cell tip" EXACT [GOC:mah] is_a: GO:0034613 ! cellular protein localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2013-07-31T14:56:40Z [Term] id: GO:1990152 name: protein localization to telomeric heterochromatin namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location in telomeric heterochromatin." [PMID:21300781] synonym: "protein localisation to telomeric heterochromatin" EXACT [GOC:mah] is_a: GO:0070198 ! protein localization to chromosome, telomeric region is_a: GO:0097355 ! protein localization to heterochromatin property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2013-07-31T15:04:26Z [Term] id: GO:1990153 name: maintenance of protein localization to heterochromatin namespace: biological_process def: "A process in which a protein is maintained in a location in telomeric heterochromatin." [PMID:21300781] synonym: "maintenance of protein localisation to heterochromatin" EXACT [GOC:mah] synonym: "maintenance of protein location in heterochromatin" RELATED [GOC:mah] is_a: GO:0032507 ! maintenance of protein location in cell relationship: part_of GO:0097355 ! protein localization to heterochromatin property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2013-07-31T15:11:37Z [Term] id: GO:1990155 name: Dsc E3 ubiquitin ligase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a Dsc E3 ubiquitin ligase complex, an E3 ubiquitin ligase complex localized to the ER and Golgi membrane." [GOC:mah, PMID:23760507] synonym: "Dsc complex assembly" EXACT [PMID:23760507] is_a: GO:0043623 ! cellular protein complex assembly property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2013-08-01T14:19:19Z [Term] id: GO:1990164 name: histone H2A phosphorylation namespace: biological_process def: "The modification of histone H2A by the addition of a phosphate group." [GOC:mah, PMID:23080121] is_a: GO:0016572 ! histone phosphorylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2013-08-08T11:13:25Z [Term] id: GO:1990166 name: protein localization to site of double-strand break namespace: biological_process def: "Any process in which a protein is transported to, or maintained at, a region of a chromosome at which a DNA double-strand break has occurred." [GOC:mah, PMID:23080121] synonym: "protein localisation to site of double-strand break" EXACT [GOC:mah] synonym: "protein localization to double-strand break site" EXACT [GOC:mah] synonym: "protein localization to site of DSB" EXACT [GOC:mah] is_a: GO:0034502 ! protein localization to chromosome property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2013-08-08T11:27:00Z [Term] id: GO:1990173 name: protein localization to nucleoplasm namespace: biological_process def: "A process in which a protein is transported to, or maintained in, a location within the nucleoplasm." [GOC:mah, PMID:22918952] synonym: "protein localisation to nucleoplasm" EXACT [GOC:mah] is_a: GO:0034504 ! protein localization to nucleus property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2013-08-23T15:01:16Z [Term] id: GO:1990179 name: protein localization to actomyosin contractile ring namespace: biological_process def: "A process in which a protein is transported to, or maintained at, the actomyosin contractile ring." [GOC:mah, PMID:23349808] synonym: "protein localisation to actomyosin contractile ring" EXACT [] is_a: GO:0072697 ! protein localization to cell cortex is_a: GO:0072741 ! protein localization to cell division site is_a: GO:1903119 ! protein localization to actin cytoskeleton property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2013-08-30T16:13:54Z [Term] id: GO:1990180 name: mitochondrial tRNA 3'-end processing namespace: biological_process def: "The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA in the mitochondrion." [GOC:mah, GOC:TermGenie, PMID:23928301] synonym: "tRNA 3' processing in mitochondria" EXACT [GOC:TermGenie] synonym: "tRNA 3' processing in mitochondrion" EXACT [GOC:TermGenie] synonym: "tRNA 3'-end processing in mitochondria" EXACT [GOC:TermGenie] is_a: GO:0000965 ! mitochondrial RNA 3'-end processing is_a: GO:0042780 ! tRNA 3'-end processing is_a: GO:0090646 ! mitochondrial tRNA processing intersection_of: GO:0042780 ! tRNA 3'-end processing intersection_of: occurs_in GO:0005739 ! mitochondrion relationship: occurs_in GO:0005739 ! mitochondrion property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2013-08-30T16:17:36Z [Term] id: GO:1990189 name: peptide-serine-N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + N-terminal L-serine in peptide = CoA + N-acetyl-L-serine-peptide." [GOC:al, PMID:23912279] is_a: GO:0004596 ! peptide alpha-N-acetyltransferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tb creation_date: 2013-09-11T20:13:40Z [Term] id: GO:1990190 name: peptide-glutamate-N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + N-terminal L-glutamate in peptide = CoA + N-acetyl-L-glutamate-peptide." [GOC:al, PMID:23912279] is_a: GO:0004596 ! peptide alpha-N-acetyltransferase activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tb creation_date: 2013-09-11T20:21:25Z [Term] id: GO:1990204 name: oxidoreductase complex namespace: cellular_component def: "Any protein complex that possesses oxidoreductase activity." [GOC:bhm, PMID:18982432] synonym: "oxidation-reduction complex" EXACT [] synonym: "redox complex" EXACT [] is_a: GO:0044464 ! cell part is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0005623 ! cell property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: bhm creation_date: 2013-10-07T08:24:47Z [Term] id: GO:1990267 name: response to transition metal nanoparticle namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transition metal nanoparticle." [PMID:23150627] synonym: "response to colloidal metal" RELATED [] synonym: "response to neutral metal atoms" RELATED [] is_a: GO:0042221 ! response to chemical property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: sl creation_date: 2014-01-10T17:16:41Z [Term] id: GO:1990274 name: mitotic actomyosin contractile ring disassembly namespace: biological_process def: "Any disaggregation of an actomyosin contractile ring into its constituent components that is involved in a mitotic cell cycle." [PMID:14602073, PMID:22891673] synonym: "mitotic actomyosin ring disassembly" RELATED [] synonym: "mitotic CAR disassembly" EXACT [] synonym: "mitotic constriction ring disassembly" RELATED [] synonym: "mitotic contractile actomyosin ring disassembly" EXACT [] synonym: "mitotic cytokinetic ring disassembly" RELATED [] is_a: GO:1902410 ! mitotic cytokinetic process is_a: GO:1902621 ! actomyosin contractile ring disassembly intersection_of: GO:1902621 ! actomyosin contractile ring disassembly intersection_of: part_of GO:0000281 ! mitotic cytokinesis relationship: part_of GO:0000281 ! mitotic cytokinesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-01-16T10:25:42Z [Term] id: GO:1990280 name: RNA localization to chromatin namespace: biological_process def: "A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin." [GOC:dos, GOC:mah, PMID:22582262] synonym: "RNA localisation to chromatin" EXACT [] is_a: GO:0006403 ! RNA localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-01-30T15:55:34Z [Term] id: GO:1990295 name: post-anaphase microtubule array namespace: cellular_component def: "A cytoskeletal part that consists of an array of microtubules and associated molecules that forms at the end of anaphase, and in which microtubules are nucleated from an equatorial microtubule organizing center." [PMID:11792817, PMID:17072892, PMID:9601091] comment: The best-characterized example is found in the fission yeast Schizosaccharomyces pombe. The eMTOC is cortical, but the post-anaphase array microtubules are not exclusively cortical. synonym: "PAA" EXACT [] synonym: "post-anaphase array" EXACT [] is_a: GO:0044430 ! cytoskeletal part relationship: has_part GO:0000923 ! equatorial microtubule organizing center relationship: part_of GO:0015630 ! microtubule cytoskeleton property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-02-20T13:54:23Z [Term] id: GO:1990342 name: heterochromatin island namespace: cellular_component def: "A region of heterochromatin that is formed dynamically in response to environmental signals by a process that does not require RNAi, and is enriched in histone H3 methylated on lysine 9 (H3K9me)." [PMID:22144463, PMID:24210919] comment: An example of this type of heterochromatin is found in Schizosaccharomyces pombe, where heterochromatin islands are formed at meiotic genes during vegetative (mitotic) growth. is_a: GO:0005720 ! nuclear heterochromatin property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-03-21T15:26:44Z [Term] id: GO:1990343 name: heterochromatin domain namespace: cellular_component def: "A region of heterochromatin that is formed dynamically under specific growth conditions by a process that requires RNAi, and is enriched in histone H3 methylated on lysine 9 (H3K9me)." [PMID:23151475, PMID:24210919] comment: An example of this type of heterochromatin is found in Schizosaccharomyces pombe, where heterochromatin domains preferentially assemble at sexual differentiation genes and retrotransposons. synonym: "HOOD" EXACT [PMID:23151475] is_a: GO:0005720 ! nuclear heterochromatin property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-03-21T15:40:48Z [Term] id: GO:1990344 name: secondary cell septum biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a secondary cell septum following nuclear division." [PMID:22891259] is_a: GO:0044085 ! cellular component biogenesis is_a: GO:1902410 ! mitotic cytokinetic process relationship: part_of GO:0000917 ! barrier septum assembly relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-03-24T13:24:48Z [Term] id: GO:1990395 name: meiotic spindle pole body organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the meiotic spindle pole body." [GOC:vw] is_a: GO:0051300 ! spindle pole body organization is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0000212 ! meiotic spindle organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tb creation_date: 2014-06-06T01:41:05Z [Term] id: GO:1990421 name: subtelomeric heterochromatin namespace: cellular_component def: "Heterochromatic regions of the chromosome found at the subtelomeric regions." [PMID:18761674, SO:0001997] synonym: "sub-telomeric heterochromatin" EXACT [] is_a: GO:0000792 ! heterochromatin property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-07-18T13:32:59Z [Term] id: GO:1990437 name: snRNA 2'-O-methylation namespace: biological_process def: "The posttranscriptional addition of a methyl group to the 2' oxygen atom of a nucleotide residue in an snRNA molecule." [PMID:11842100, PMID:9844635] is_a: GO:0001510 ! RNA methylation is_a: GO:0040031 ! snRNA modification property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-07-31T11:58:18Z [Term] id: GO:1990438 name: U6 2'-O-snRNA methylation namespace: biological_process def: "The posttranscriptional addition a methyl group to the 2'-oxygen atom of a nucleotide residue in an U6 snRNA molecule." [PMID:11842100, PMID:9844635] is_a: GO:1990437 ! snRNA 2'-O-methylation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-07-31T12:04:21Z [Term] id: GO:1990446 name: U1 snRNP binding namespace: molecular_function def: "Interacting selectively and non-covalently with any part of a U1 small nuclear ribonucleoprotein particle." [PMID:14713954] is_a: GO:0070990 ! snRNP binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-08-06T09:29:44Z [Term] id: GO:1990447 name: U2 snRNP binding namespace: molecular_function def: "Interacting selectively and non-covalently with any part of a U2 small nuclear ribonucleoprotein particle." [PMID:14713954] is_a: GO:0070990 ! snRNP binding property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-08-06T09:33:38Z [Term] id: GO:1990463 name: lateral cortical node namespace: cellular_component def: "A protein complex that is anchored at the cortical face of the plasma membrane, and contains proteins involved in regulating cell cycle progression. In Schizosaccharomyces pombe, lateral cortical nodes are several megadaltons in size, and contain Slf1, which anchors the complex at the membrane, and the methyltransferase Skb1 in stoichiometric quantities, and may contain other proteins." [GOC:mah, PMID:25009287] synonym: "Skb1-containing cortical node" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044448 ! cell cortex part relationship: part_of GO:0097575 ! lateral cell cortex property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: pr creation_date: 2014-08-20T09:04:45Z [Term] id: GO:1990571 name: meiotic centromere clustering namespace: biological_process def: "The process by which centromeres/kinetochores become localized to clusters during a meiotic nuclear division. For example, in Schizosaccharomyces pombe, centromeres are located in one or two clusters away from the spindle pole body during meiosis." [PMID:10366596, PMID:9009280] synonym: "centromere clustering during meiosis" EXACT [] is_a: GO:0070192 ! chromosome organization involved in meiosis is_a: GO:0098653 ! centromere clustering is_a: GO:1902580 ! single-organism cellular localization relationship: part_of GO:0045132 ! meiotic chromosome segregation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2014-12-02T11:25:37Z [Term] id: GO:1990700 name: nucleolar chromatin organization namespace: biological_process def: "Any process that results in the specification, formation or maintenance of the physical structure of nucleolar chromatin." [PMID:18362178] synonym: "establishment or maintenance of nucleolar chromatin architecture" EXACT [] synonym: "nucleolar chromatin organisation" EXACT [] is_a: GO:0016043 ! cellular component organization relationship: part_of GO:0006325 ! chromatin organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2015-03-16T12:11:01Z [Term] id: GO:1990734 name: astral microtubule anchoring at mitotic spindle pole body namespace: biological_process def: "Any process in which an astral microtubule is maintained in a specific location in a cell by attachment to a mitotic spindle pole body. Microtubules attach to spindle pole bodies at the minus end." [PMID:15004232] subset: termgenie_unvetted is_a: GO:0034631 ! microtubule anchoring at spindle pole body property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: vw creation_date: 2015-04-28T12:15:18Z [Term] id: GO:1990735 name: gamma-tubulin complex localization to mitotic spindle pole body namespace: biological_process def: "Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at a mitotic spindle pole body." [GOC:dos, GOC:mah, PMID:11080156] synonym: "establishment and maintenance of gamma-tubulin complex localization to mitotic spindle pole body" EXACT [] synonym: "gamma-tubulin complex localisation to mitotic spindle pole body" EXACT [] synonym: "gamma-tubulin complex localization to mitotic SPB" EXACT [] is_a: GO:0033566 ! gamma-tubulin complex localization is_a: GO:1902440 ! protein localization to mitotic spindle pole body property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2015-04-29T14:40:20Z [Term] id: GO:1990755 name: mitotic spindle microtubule depolymerization namespace: biological_process def: "The removal of tubulin heterodimers from one or both ends of a microtubule that is part of the mitotic spindle." [PMID:25253718] synonym: "mitotic spindle microtubule depolymerisation" EXACT [] is_a: GO:0007019 ! microtubule depolymerization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: mah creation_date: 2015-05-28T15:42:06Z [Term] id: GO:1990778 name: protein localization to cell periphery namespace: biological_process def: "A process in which a protein is transported to, or maintained in, the cell periphery." [PMID:18216290] is_a: GO:0034613 ! cellular protein localization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl creation_date: 2015-06-18T22:37:39Z [Term] id: GO:1990814 name: DNA/DNA annealing activity namespace: molecular_function def: "A nucleic acid binding activity that brings together complementary sequences of ssDNA so that they pair by hydrogen bonds to form a double-stranded DNA." [PMID:25520186] is_a: GO:0097617 ! annealing activity property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: vw creation_date: 2015-07-29T12:35:03Z [Term] id: GO:2000045 name: regulation of G1/S transition of mitotic cell cycle namespace: biological_process def: "Any cell cycle regulatory process that controls the commitment of a cell from G1 to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] comment: Note that this process is usually achieved by the regulation of the G1 cyclin-dependent protein kinase, consider annotating to the child term 'regulation of cyclin-dependent protein kinase activity involved in G1/S ; GO:0031657'. is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition is_a: GO:1902806 ! regulation of cell cycle G1/S phase transition intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0000082 ! G1/S transition of mitotic cell cycle relationship: regulates GO:0000082 ! G1/S transition of mitotic cell cycle property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2010-08-19T09:10:56Z [Term] id: GO:2000104 name: negative regulation of DNA-dependent DNA replication namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent DNA replication." [GOC:mah] is_a: GO:0008156 ! negative regulation of DNA replication is_a: GO:0090329 ! regulation of DNA-dependent DNA replication intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006261 ! DNA-dependent DNA replication relationship: negatively_regulates GO:0006261 ! DNA-dependent DNA replication property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-09-15T01:37:05Z [Term] id: GO:2000112 name: regulation of cellular macromolecule biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular macromolecule biosynthetic process." [GOC:obol] synonym: "regulation of cellular biopolymer biosynthetic process" EXACT [GOC:obol] synonym: "regulation of cellular macromolecule anabolism" EXACT [GOC:obol] synonym: "regulation of cellular macromolecule biosynthesis" EXACT [GOC:obol] synonym: "regulation of cellular macromolecule formation" EXACT [GOC:obol] synonym: "regulation of cellular macromolecule synthesis" EXACT [GOC:obol] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0031326 ! regulation of cellular biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0034645 ! cellular macromolecule biosynthetic process relationship: regulates GO:0034645 ! cellular macromolecule biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2010-09-15T08:55:45Z [Term] id: GO:2000113 name: negative regulation of cellular macromolecule biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular macromolecule biosynthetic process." [GOC:obol] synonym: "negative regulation of cellular biopolymer biosynthetic process" EXACT [GOC:obol] synonym: "negative regulation of cellular macromolecule anabolism" EXACT [GOC:obol] synonym: "negative regulation of cellular macromolecule biosynthesis" EXACT [GOC:obol] synonym: "negative regulation of cellular macromolecule formation" EXACT [GOC:obol] synonym: "negative regulation of cellular macromolecule synthesis" EXACT [GOC:obol] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0034645 ! cellular macromolecule biosynthetic process relationship: negatively_regulates GO:0034645 ! cellular macromolecule biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: tanyaberardini creation_date: 2010-09-15T08:55:48Z [Term] id: GO:2000241 name: regulation of reproductive process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reproductive process." [GOC:mah] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0022414 ! reproductive process relationship: regulates GO:0022414 ! reproductive process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2010-11-10T02:44:02Z [Term] id: GO:2000278 name: regulation of DNA biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] synonym: "regulation of DNA anabolism" EXACT [GOC:obol] synonym: "regulation of DNA biosynthesis" EXACT [GOC:obol] synonym: "regulation of DNA formation" EXACT [GOC:obol] synonym: "regulation of DNA synthesis" EXACT [GOC:obol] is_a: GO:0051052 ! regulation of DNA metabolic process is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0071897 ! DNA biosynthetic process relationship: regulates GO:0071897 ! DNA biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: yaf creation_date: 2010-12-08T04:48:15Z [Term] id: GO:2000573 name: positive regulation of DNA biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol] synonym: "positive regulation of DNA anabolism" EXACT [GOC:obol] synonym: "positive regulation of DNA biosynthesis" EXACT [GOC:obol] synonym: "positive regulation of DNA formation" EXACT [GOC:obol] synonym: "positive regulation of DNA synthesis" EXACT [GOC:obol] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0051054 ! positive regulation of DNA metabolic process is_a: GO:2000278 ! regulation of DNA biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0071897 ! DNA biosynthetic process relationship: positively_regulates GO:0071897 ! DNA biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: yaf creation_date: 2011-04-04T10:01:20Z [Term] id: GO:2000689 name: actomyosin contractile ring assembly actin filament organization namespace: biological_process def: "An actin filament organization process that contributes to actomyosin contractile ring assembly during cytokinesis." [GOC:mah] synonym: "actin filament organisation of constriction ring assembly" RELATED [GOC:obol] synonym: "actin filament organisation of contractile ring assembly" EXACT [GOC:obol] synonym: "actin filament organisation of cytokinesis, actomyosin contractile ring assembly" EXACT [GOC:obol] synonym: "actin filament organisation of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol] synonym: "actin filament organisation of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol] synonym: "actin filament organisation of cytokinesis, actomyosin ring formation" RELATED [GOC:obol] synonym: "actin filament organisation of cytokinesis, contractile ring assembly" RELATED [GOC:obol] synonym: "actin filament organization involved in cytokinetic actomyosin contractile ring assembly" EXACT [] synonym: "actin filament organization of constriction ring assembly" RELATED [GOC:obol] synonym: "actin filament organization of contractile ring assembly" EXACT [GOC:obol] synonym: "actin filament organization of cytokinesis, actomyosin contractile ring assembly" EXACT [GOC:obol] synonym: "actin filament organization of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol] synonym: "actin filament organization of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol] synonym: "actin filament organization of cytokinesis, actomyosin ring formation" RELATED [GOC:obol] synonym: "actin filament organization of cytokinesis, contractile ring assembly" RELATED [GOC:obol] synonym: "regulation of actin filament localization of constriction ring assembly" RELATED [GOC:obol] synonym: "regulation of actin filament localization of contractile ring assembly" RELATED [GOC:obol] synonym: "regulation of actin filament localization of cytokinesis, actomyosin contractile ring assembly" RELATED [GOC:obol] synonym: "regulation of actin filament localization of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol] synonym: "regulation of actin filament localization of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol] synonym: "regulation of actin filament localization of cytokinesis, actomyosin ring formation" RELATED [GOC:obol] synonym: "regulation of actin filament localization of cytokinesis, contractile ring assembly" RELATED [GOC:obol] is_a: GO:0007015 ! actin filament organization is_a: GO:0022402 ! cell cycle process intersection_of: GO:0007015 ! actin filament organization intersection_of: part_of GO:0000915 ! actomyosin contractile ring assembly relationship: part_of GO:0000915 ! actomyosin contractile ring assembly property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2011-05-17T11:48:12Z [Term] id: GO:2000708 name: myosin filament organization involved in cytokinetic actomyosin contractile ring assembly namespace: biological_process def: "A myosin filament organization process that contributes to actomyosin contractile ring assembly during cytokinesis." [GOC:mah] synonym: "myosin filament assembly or disassembly of constriction ring assembly" RELATED [GOC:obol] synonym: "myosin filament assembly or disassembly of contractile ring assembly" RELATED [GOC:obol] synonym: "myosin filament assembly or disassembly of cytokinesis, actomyosin contractile ring assembly" RELATED [GOC:obol] synonym: "myosin filament assembly or disassembly of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol] synonym: "myosin filament assembly or disassembly of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol] synonym: "myosin filament assembly or disassembly of cytokinesis, actomyosin ring formation" RELATED [GOC:obol] synonym: "myosin filament assembly or disassembly of cytokinesis, contractile ring assembly" RELATED [GOC:obol] synonym: "myosin filament organisation involved in cytokinetic actomyosin contractile ring assembly" EXACT [GOC:mah] synonym: "myosin filament organization of constriction ring assembly" RELATED [GOC:obol] synonym: "myosin filament organization of contractile ring assembly" EXACT [GOC:obol] synonym: "myosin filament organization of cytokinesis, actomyosin contractile ring assembly" EXACT [GOC:obol] synonym: "myosin filament organization of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol] synonym: "myosin filament organization of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol] synonym: "myosin filament organization of cytokinesis, actomyosin ring formation" RELATED [GOC:obol] synonym: "myosin filament organization of cytokinesis, contractile ring assembly" RELATED [GOC:obol] synonym: "myosin polymerization or depolymerization of constriction ring assembly" RELATED [GOC:obol] synonym: "myosin polymerization or depolymerization of contractile ring assembly" RELATED [GOC:obol] synonym: "myosin polymerization or depolymerization of cytokinesis, actomyosin contractile ring assembly" RELATED [GOC:obol] synonym: "myosin polymerization or depolymerization of cytokinesis, actomyosin contractile ring formation" RELATED [GOC:obol] synonym: "myosin polymerization or depolymerization of cytokinesis, actomyosin ring biosynthesis" RELATED [GOC:obol] synonym: "myosin polymerization or depolymerization of cytokinesis, actomyosin ring formation" RELATED [GOC:obol] synonym: "myosin polymerization or depolymerization of cytokinesis, contractile ring assembly" RELATED [GOC:obol] is_a: GO:0022402 ! cell cycle process is_a: GO:0031033 ! myosin filament organization intersection_of: GO:0031033 ! myosin filament organization intersection_of: part_of GO:0000915 ! actomyosin contractile ring assembly relationship: part_of GO:0000915 ! actomyosin contractile ring assembly property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2011-06-01T12:33:56Z [Term] id: GO:2000816 name: negative regulation of mitotic sister chromatid separation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of mitotic sister chromatid separation." [GOC:obol] synonym: "negative regulation of chromosome separation during mitosis" RELATED [GOC:obol] synonym: "negative regulation of mitotic chromosome separation" RELATED [GOC:obol] synonym: "negative regulation of mitotic sister chromatid resolution" EXACT [GOC:obol] synonym: "negative regulation of sister chromatid separation during mitosis" EXACT [GOC:obol] is_a: GO:0010965 ! regulation of mitotic sister chromatid separation is_a: GO:0033048 ! negative regulation of mitotic sister chromatid segregation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0051306 ! mitotic sister chromatid separation relationship: negatively_regulates GO:0051306 ! mitotic sister chromatid separation property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: midori creation_date: 2011-07-11T04:45:06Z [Term] id: GO:2001141 name: regulation of RNA biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of RNA biosynthetic process." [GOC:dph] synonym: "regulation of RNA anabolism" EXACT [GOC:obol] synonym: "regulation of RNA biosynthesis" EXACT [GOC:obol] synonym: "regulation of RNA formation" EXACT [GOC:obol] synonym: "regulation of RNA synthesis" EXACT [GOC:obol] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0032774 ! RNA biosynthetic process relationship: regulates GO:0032774 ! RNA biosynthetic process property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: dph creation_date: 2011-10-17T11:36:25Z [Term] id: GO:2001251 name: negative regulation of chromosome organization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of chromosome organization." [GOC:obol] synonym: "negative regulation of chromosome organisation" EXACT [GOC:obol] synonym: "negative regulation of chromosome organization and biogenesis" RELATED [GOC:obol] synonym: "negative regulation of maintenance of genome integrity" RELATED [GOC:obol] synonym: "negative regulation of nuclear genome maintenance" RELATED [GOC:obol] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0033044 ! regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0051276 ! chromosome organization relationship: negatively_regulates GO:0051276 ! chromosome organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: yaf creation_date: 2011-12-02T02:01:20Z [Term] id: GO:2001252 name: positive regulation of chromosome organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chromosome organization." [GOC:obol] synonym: "positive regulation of chromosome organisation" EXACT [GOC:obol] synonym: "positive regulation of chromosome organization and biogenesis" RELATED [GOC:obol] synonym: "positive regulation of maintenance of genome integrity" RELATED [GOC:obol] synonym: "positive regulation of nuclear genome maintenance" RELATED [GOC:obol] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0033044 ! regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0051276 ! chromosome organization relationship: positively_regulates GO:0051276 ! chromosome organization property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl created_by: yaf creation_date: 2011-12-02T02:01:26Z [Term] id: PATO:0000001 name: quality namespace: quality alt_id: PATO:0000072 def: "A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities" [PATOC:GVG] synonym: "trait" EXACT [] property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000004 name: mobility namespace: quality def: "A quality of inhering in a bearer by virtue of the bearer's disposition to move freely." [PATOC:GVG] comment: Should be defined using translocation. subset: attribute_slim subset: disposition_slim subset: scalar_slim is_a: PATO:0001018 ! physical quality property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000033 name: concentration of namespace: quality def: "A quality inhering in a substance by virtue of the amount of the bearer's there is mixed with another substance." [Wikipedia:http\://en.wikipedia.org/wiki/concentration] subset: attribute_slim subset: relational_slim subset: scalar_slim synonym: "concentration" EXACT [] is_a: PATO:0002182 ! molecular quality property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000044 name: frequency namespace: quality def: "A physical quality which inheres in a bearer by virtue of the number of the bearer's repetitive actions in a particular time." [Wikipedia:http\://en.wikipedia.org/wiki/frequency] subset: attribute_slim subset: scalar_slim is_a: PATO:0000161 ! rate property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000051 name: morphology namespace: quality def: "A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure." [PATOC:GVG] subset: attribute_slim is_a: PATO:0001241 ! physical object quality property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000052 name: shape namespace: quality alt_id: PATO:0001647 def: "A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc)." [PATOC:GVG] comment: Shapes are invariant on size transformations. Shapes can be subdivided into 2D and 3D shapes, We can also make a distinction between shapes of complete self-connected objects, and shapes of parts of objects. subset: attribute_slim synonym: "relational shape quality" EXACT [] is_a: PATO:0000051 ! morphology property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000056 name: trophic quality namespace: quality def: "An organismal quality inhering in a bearer by virtue of the bearer's disposition to synthesize a particular organic compound required for its growth." [Wikipedia:http\://en.wikipedia.org/wiki/Trophic_level] subset: attribute_slim subset: disposition_slim synonym: "nutritional quality" RELATED [] is_a: PATO:0001995 ! organismal quality property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000057 name: occurrence namespace: quality alt_id: PATO:0000156 alt_id: PATO:0000158 def: "A quality of a single process inhering in a bearer by virtue of the bearer's occurrence." [PATOC:GVG] subset: attribute_slim subset: hpo_slim synonym: "incidence" EXACT [] synonym: "temporal" BROAD [] is_a: PATO:0002323 ! temporal distribution quality property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000060 name: spatial pattern namespace: quality alt_id: PATO:0000132 alt_id: PATO:0001565 def: "A spatial quality inhering in a bearer by virtue of the bearer's exhibiting repetition of placement of its parts." [PATOC:GVG] subset: attribute_slim subset: hpo_slim synonym: "distribution" EXACT [] synonym: "pattern" RELATED [] is_a: PATO:0000140 ! position property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000068 name: qualitative namespace: quality comment: TODO: define this or obsolete it and move children somewhere else. is_a: PATO:0000001 ! quality property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000069 name: deviation(from_normal) namespace: quality def: "A quality inhering in a bearer by virtue of the whether the bearer differs from normal or average." [PATOC:GVG] subset: attribute_slim is_a: PATO:0000068 ! qualitative property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000070 name: amount namespace: quality alt_id: PATO:0000053 alt_id: PATO:0000071 alt_id: PATO:0001169 alt_id: PATO:0001226 def: "The number of entities of this type that are part of the whole organism." [PATOC:GVG] comment: This term was originally named "presence". It has been renamed to reduce ambiguity. Consider annotating with the reciprocal relation,PATO:0001555, has_number_of. For example, rather than E=fin ray Q=count in organism C=10, say E=organism Q=has number of E2= fin ray C=10. subset: attribute_slim synonym: "count" EXACT [] synonym: "count in organism" RELATED [] synonym: "number" RELATED [] synonym: "presence" RELATED [] synonym: "presence or absence in organism" EXACT [] synonym: "quantitative" EXACT [] is_a: PATO:0000068 ! qualitative relationship: reciprocal_of PATO:0001555 ! has number of property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000117 name: size namespace: quality def: "A morphology quality inhering in a bearer by virtue of the bearer's physical magnitude." [WordNet:WordNet] subset: attribute_slim subset: scalar_slim is_a: PATO:0000051 ! morphology property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000122 name: length namespace: quality def: "A 1-D extent quality which is equal to the distance between two points." [PATOC:GVG] subset: attribute_slim subset: mpath_slim subset: scalar_slim is_a: PATO:0001708 ! 1-D extent property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000133 name: orientation namespace: quality alt_id: PATO:0000137 def: "A spatial quality inhering in a bearer by virtue of the bearer's placement which is defined by the angle between the bearer and an axis, or the angle between the bearer and another object." [PATOC:JE] subset: attribute_slim subset: relational_slim synonym: "amount of rotation" RELATED [] synonym: "angle" RELATED [] synonym: "angular magnitude" RELATED [] synonym: "angular placement" EXACT [] synonym: "plane angle" RELATED [] is_a: PATO:0000140 ! position property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000140 name: position namespace: quality alt_id: PATO:0001032 alt_id: PATO:0001631 def: "A spatial quality inhering in a bearer by virtue of the bearer's spatial location relative to other objects in the vicinity." [PATOC:GVG] subset: attribute_slim synonym: "location" EXACT [] synonym: "placement" EXACT [] synonym: "relational spatial quality" EXACT [] is_a: PATO:0001018 ! physical quality property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000141 name: structure namespace: quality alt_id: PATO:0001452 def: "A morphology quality inhering in a bearer by virtue of the bearer's relative position, shape, arrangements and connectivity of an organism's various parts; the pattern underlying its form." [PATOC:GVG] subset: attribute_slim synonym: "relational structural quality" EXACT [] is_a: PATO:0000051 ! morphology property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000146 name: temperature namespace: quality def: "A physical quality of the thermal energy of a system." [PATOC:GVG] subset: attribute_slim subset: scalar_slim is_a: PATO:0001018 ! physical quality property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000150 name: texture namespace: quality def: "A morphologic quality inhering in a bearer by virtue of the bearer's relative size, organization and distribution of its surface elements or the representation or invention of the appearance of its surface; visual and tactile surface characteristics." [PATOC:GVG] subset: attribute_slim is_a: PATO:0000051 ! morphology property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000161 name: rate namespace: quality def: "A quality of a single process inhering in a bearer by virtue of the bearer's occurrence per unit time." [PATOC:melissa] subset: attribute_slim subset: scalar_slim is_a: PATO:0002062 ! physical quality of a process property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000169 name: viability namespace: quality def: "An organismal quality inhering in a bearer or a population by virtue of the bearer's disposition to survive and develop normally or the number of surviving individuals in a given population." [PATOC:GVG] subset: attribute_slim subset: disposition_slim is_a: PATO:0001995 ! organismal quality property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000330 name: irregular spatial pattern namespace: quality def: "A spatial pattern inhering in a bearer by virtue of the bearer's magnitude of or the relationships between its repeated parts lack consistency." [PATOC:GVG] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0000060 ! spatial pattern property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000402 name: branched namespace: quality def: "A branchiness quality inhering in a bearer by virtue of the bearer's having branches." [WordNet:WordNet] subset: cell_quality subset: mpath_slim subset: value_slim synonym: "ramified" EXACT [] synonym: "ramiform" EXACT [] is_a: PATO:0002009 ! branchiness property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000406 name: curved namespace: quality def: "A curvature quality inhering in a bearer by virtue of the bearer's having or being marked by a curve or smoothly rounded bend." [WordNet:WordNet] subset: cell_quality subset: value_slim synonym: "bowing" NARROW [] synonym: "curled" RELATED [] is_a: PATO:0001591 ! curvature property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000411 name: circular namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's being such that every part of the surface or the circumference is equidistant from the center." [thefreedictionary.com:thefreedictionary.com] subset: cell_quality subset: mpath_slim subset: value_slim synonym: "round" RELATED [] synonym: "rounded" RELATED [] is_a: PATO:0000947 ! elliptic property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000422 name: auxotrophic namespace: quality def: "A nutritional quality inhering in a bearer by virtue of the bearer's inability to synthesize a particular organic compound required for its growth." [Wikipedia:http\://en.wikipedia.org/wiki/Auxotrophic] subset: disposition_slim subset: value_slim is_a: PATO:0000056 ! trophic quality property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000460 name: abnormal namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's deviation from normal or average." [PATOC:GVG] subset: abnormal_slim subset: mpath_slim subset: value_slim synonym: "aberrant" RELATED [] synonym: "atypia" RELATED [] synonym: "atypical" RELATED [] synonym: "defective" RELATED [] is_a: PATO:0000069 ! deviation(from_normal) property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000461 name: normal namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's exhibiting no deviation from normal or average." [PATOC:GVG] subset: abnormal_slim subset: mpath_slim subset: value_slim synonym: "average" RELATED [] is_a: PATO:0000069 ! deviation(from_normal) property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000467 name: present namespace: quality def: "A quality inhering in a bearer by virtue of the bearer's existence." [PATOC:GVG] subset: absent_slim subset: value_slim synonym: "present in organism" RELATED [] is_a: PATO:0000070 ! amount property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000498 name: increased duration namespace: quality alt_id: PATO:0000715 def: "A duration quality of a process which is relatively high." [PATOC:GVG] subset: value_slim synonym: "chronic" RELATED [] synonym: "high time" EXACT [] synonym: "increased period" EXACT [] synonym: "increased time" EXACT [] synonym: "prolonged period" RELATED [] synonym: "slow time" RELATED [] is_a: PATO:0001309 ! duration is_a: PATO:0002304 ! increased process quality intersection_of: PATO:0001309 ! duration intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: increased_in_magnitude_relative_to PATO:0000461 ! normal property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000499 name: decreased duration namespace: quality alt_id: PATO:0000716 def: "A duration quality of a process which is relatively low." [PATOC:GVG] subset: value_slim synonym: "decreased period" EXACT [] synonym: "decreased time" EXACT [] synonym: "fast time" RELATED [] synonym: "low period" EXACT [] synonym: "shortened period" EXACT [] is_a: PATO:0001309 ! duration is_a: PATO:0002302 ! decreased process quality intersection_of: PATO:0001309 ! duration intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: decreased_in_magnitude_relative_to PATO:0000461 ! normal property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000502 name: delayed namespace: quality def: "A quality of a process which starts later than the natural start time or the reference process." [PATOC:LC] subset: value_slim synonym: "late" RELATED [] is_a: PATO:0002325 ! onset quality property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000573 name: increased length namespace: quality def: "A length quality which is relatively large." [PATOC:GVG] subset: value_slim synonym: "long" EXACT [] is_a: PATO:0000122 ! length is_a: PATO:0000586 ! increased size intersection_of: PATO:0000122 ! length intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: increased_in_magnitude_relative_to PATO:0000461 ! normal property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000574 name: decreased length namespace: quality def: "A length quality which is relatively small." [PATOC:GVG] subset: value_slim synonym: "short" EXACT [] synonym: "shortened" RELATED [] synonym: "stubby" RELATED [] is_a: PATO:0000122 ! length is_a: PATO:0000587 ! decreased size intersection_of: PATO:0000122 ! length intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: decreased_in_magnitude_relative_to PATO:0000461 ! normal property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000586 name: increased size namespace: quality alt_id: PATO:0001202 def: "A size quality which is relatively high." [PATOC:GVG] subset: value_slim synonym: "big" RELATED [] synonym: "enlarged" RELATED [] synonym: "expanded" RELATED [] synonym: "great" RELATED [] synonym: "large" RELATED [] is_a: PATO:0000117 ! size is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0000117 ! size intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: increased_in_magnitude_relative_to PATO:0000461 ! normal property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000587 name: decreased size namespace: quality def: "A size quality which is relatively low." [PATOC:GVG] subset: value_slim synonym: "hypoplasia" NARROW [] synonym: "reduced" RELATED [] synonym: "small" RELATED [] synonym: "tiny" RELATED [] synonym: "underdeveloped" NARROW [] is_a: PATO:0000117 ! size is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0000117 ! size intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: decreased_in_magnitude_relative_to PATO:0000461 ! normal property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000591 name: increased thickness namespace: quality def: "A thickness which is relatively high." [PATOC:GVG] subset: mpath_slim subset: value_slim synonym: "high thickness" EXACT [] synonym: "stout" EXACT [] synonym: "thick" RELATED [] synonym: "thickened" EXACT [] is_a: PATO:0000586 ! increased size is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: increased_in_magnitude_relative_to PATO:0000461 ! normal property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000592 name: decreased thickness namespace: quality def: "A thickness which is relatively low." [PATOC:GVG] subset: mpath_slim subset: value_slim synonym: "low thickness" EXACT [] synonym: "slender" RELATED [] synonym: "thin" RELATED [] is_a: PATO:0000587 ! decreased size is_a: PATO:0000915 ! thickness intersection_of: PATO:0000915 ! thickness intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: decreased_in_magnitude_relative_to PATO:0000461 ! normal property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000595 name: increased volume namespace: quality def: "A volume which is relatively high." [PATOC:GVG] subset: mpath_slim subset: value_slim synonym: "high volume" EXACT [] synonym: "large volume" RELATED [] is_a: PATO:0000586 ! increased size is_a: PATO:0000918 ! volume intersection_of: PATO:0000918 ! volume intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: increased_in_magnitude_relative_to PATO:0000461 ! normal property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000596 name: decreased volume namespace: quality def: "A volume which is relatively low." [PATOC:GVG] subset: mpath_slim subset: value_slim synonym: "low volume" EXACT [] synonym: "small volume" RELATED [] is_a: PATO:0000587 ! decreased size is_a: PATO:0000918 ! volume intersection_of: PATO:0000918 ! volume intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: decreased_in_magnitude_relative_to PATO:0000461 ! normal property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000617 name: bent namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's having one or more angle(s) in its length." [PATOC:MAH] subset: value_slim is_a: PATO:0000052 ! shape property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000628 name: mislocalised namespace: quality alt_id: PATO:0000621 def: "A positional quality inhering in a bearer by virtue the bearer's being changed in abnormal position." [PATOC:GVG] subset: disposition_slim subset: value_slim synonym: "ectopic" EXACT [] synonym: "mislocalized" EXACT [] is_a: PATO:0002181 ! displaced property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000642 name: fused with namespace: quality def: "A structural quality inhering in a bearer by virtue of the bearer's being merged with another entity." [PATOC:GVG] subset: mpath_slim subset: relational_slim subset: value_slim synonym: "coalesced" RELATED [] synonym: "fused" EXACT [] synonym: "fused to" EXACT [] synonym: "joined with" RELATED [] synonym: "merged with" RELATED [] is_a: PATO:0000141 ! structure property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000689 name: continuous namespace: quality alt_id: PATO:0000429 def: "A quality of a single process inhering in a bearer by virtue of the bearer's being uninterrupted in time, sequence, substance, or extent." [thefreedictionary.com:thefreedictionary.com] subset: value_slim synonym: "uninterrupted" EXACT [] is_a: PATO:0000057 ! occurrence property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000690 name: discontinuous namespace: quality alt_id: PATO:0000426 def: "A quality of a single process inhering in a bearer by virtue of the bearer's being marked by breaks or interruptions." [thefreedictionary.com:thefreedictionary.com] subset: value_slim synonym: "intermittent" RELATED [] synonym: "interrupted" EXACT [] is_a: PATO:0000057 ! occurrence property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000694 name: premature namespace: quality alt_id: PATO:0000691 alt_id: PATO:0002086 def: "A quality of a process which starts earlier than the natural start time or the reference process." [PATO:LC] subset: value_slim synonym: "advanced" EXACT [] synonym: "early" RELATED [] synonym: "precocious" RELATED [] is_a: PATO:0002325 ! onset quality property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000700 name: rough namespace: quality alt_id: PATO:0001616 def: "A texture quality inhering in a bearer by virtue of the bearer's irregular surface." [PATOC:GVG] subset: mpath_slim subset: value_slim synonym: "coarse" EXACT [] is_a: PATO:0000150 ! texture property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000718 name: lethal (sensu genetics) namespace: quality def: "A viability quality inhering in a population by virtue of the bearer's long term survival inability." [PATOC:GVG] subset: disposition_slim subset: value_slim is_a: PATO:0000169 ! viability property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000719 name: viable namespace: quality def: "A viability quality inhering in a bearer or a population by virtue of the bearer's ability to survive or the long term survival ability of a given population." [PATOC:GVG] subset: disposition_slim subset: value_slim is_a: PATO:0000169 ! viability property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000911 name: decreased rate namespace: quality def: "A rate which is relatively low." [PATO:GVG] subset: mpath_slim subset: value_slim synonym: "slow rate" EXACT [] is_a: PATO:0000161 ! rate is_a: PATO:0002302 ! decreased process quality intersection_of: PATO:0000161 ! rate intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: decreased_in_magnitude_relative_to PATO:0000461 ! normal property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000912 name: increased rate namespace: quality def: "A rate which is relatively high." [PATO:GVG] subset: mpath_slim subset: value_slim synonym: "fast rate" EXACT [] synonym: "high rate" EXACT [] is_a: PATO:0000161 ! rate is_a: PATO:0002304 ! increased process quality intersection_of: PATO:0000161 ! rate intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: increased_in_magnitude_relative_to PATO:0000461 ! normal property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000915 name: thickness namespace: quality def: "A 1-D extent quality which is equal to the dimension through an object as opposed to its length or width." [WordNet:WordNet] subset: attribute_slim subset: scalar_slim is_a: PATO:0001708 ! 1-D extent property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000918 name: volume namespace: quality def: "A 3-D extent quality inhering in a bearer by virtue of the bearer's amount of 3-dimensional space it occupies." [PATOC:GVG] subset: attribute_slim subset: mpath_slim subset: scalar_slim is_a: PATO:0001710 ! 3-D extent property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0000947 name: elliptic namespace: quality def: "A spheroid quality inhering in a bearer by virtue of the bearer's being oval with two axes of symmetry, as produced by a conical section." [PATOC:GVG] subset: cell_quality subset: mpath_slim subset: value_slim synonym: "ellipse-shaped" EXACT [] synonym: "ellipsoid" EXACT [] synonym: "elliptical" EXACT [] synonym: "oval" RELATED [] synonym: "ovoid" RELATED [] is_a: PATO:0002318 ! superelliptic property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001018 name: physical quality namespace: quality alt_id: PATO:0002079 def: "A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities." [PATOC:GVG] subset: attribute_slim synonym: "relational physical quality" EXACT [] xref: Wikipedia:Physical_property is_a: PATO:0001241 ! physical object quality property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001159 name: concentrated namespace: quality def: "A concentration quality inhering in a bearer by virtue of the bearer's exhibiting concentration." [PATOC:GVG] subset: relational_slim subset: value_slim is_a: PATO:0000033 ! concentration of property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001162 name: increased concentration namespace: quality def: "A concentration which is higher relative to the normal or average." [PATOC:GVG] subset: relational_slim subset: value_slim synonym: "high concentration" EXACT [] is_a: PATO:0001159 ! concentrated is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0001159 ! concentrated intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: increased_in_magnitude_relative_to PATO:0000461 ! normal property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001163 name: decreased concentration namespace: quality def: "A concentration which is lower relative to the normal or average." [PATOC:GVG] subset: relational_slim subset: value_slim synonym: "low concentration" EXACT [] is_a: PATO:0001159 ! concentrated is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0001159 ! concentrated intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: decreased_in_magnitude_relative_to PATO:0000461 ! normal property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001236 name: process quality namespace: quality alt_id: PATO:0001239 alt_id: PATO:0001240 def: "A quality which inheres in an process." [PATOC:GVG] comment: See comments of relational quality of a physical entity. synonym: "quality of a process" EXACT [] synonym: "quality of occurrent" EXACT [] synonym: "quality of process" EXACT [] synonym: "relational quality of occurrent" EXACT [] is_a: PATO:0000001 ! quality property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001241 name: physical object quality namespace: quality alt_id: PATO:0001237 alt_id: PATO:0001238 def: "A quality which inheres in a continuant." [PATOC:GVG] comment: Relational qualities are qualities that hold between multiple entities. Normal (monadic) qualities such as the shape of a eyeball exist purely as a quality of that eyeball. A relational quality such as sensitivity to light is a quality of that eyeball (and connecting nervous system) as it relates to incoming light waves/particles. synonym: "monadic quality of a continuant" EXACT [] synonym: "monadic quality of an object" NARROW [] synonym: "monadic quality of continuant" NARROW [] synonym: "multiply inhering quality of a physical entity " EXACT [] synonym: "quality of a continuant" EXACT [] synonym: "quality of a single physical entity" EXACT [] synonym: "quality of an object" EXACT [] synonym: "quality of continuant" EXACT [] xref: snap:Quality is_a: PATO:0000001 ! quality property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001305 name: increased temperature namespace: quality alt_id: PATO:0000678 def: "A temperature which is relatively high." [PATOC:GVG] subset: value_slim synonym: "high temperature" EXACT [] synonym: "hot" EXACT [] is_a: PATO:0000146 ! temperature is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0000146 ! temperature intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: increased_in_magnitude_relative_to PATO:0000461 ! normal property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001306 name: decreased temperature namespace: quality alt_id: PATO:0000677 def: "A temperature which is relatively low." [PATOC:GVG] subset: value_slim synonym: "cold" EXACT [] synonym: "low temperature" EXACT [] is_a: PATO:0000146 ! temperature is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0000146 ! temperature intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: decreased_in_magnitude_relative_to PATO:0000461 ! normal property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001309 name: duration namespace: quality alt_id: PATO:0000081 def: "A process quality inhering in a bearer by virtue of the bearer's magnitude of the temporal extent between the starting and ending point." [PATOC:mellybelly] subset: attribute_slim subset: hpo_slim synonym: "period" EXACT [] synonym: "time" RELATED [] is_a: PATO:0002062 ! physical quality of a process property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001367 name: lobate namespace: quality def: "A surface feature shape quality inhering in a bearer by virtue of the bearer's having deeply undulating edges forming lobes." [PATOC:GVG] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0001925 ! surface feature shape property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001396 name: cellular quality namespace: quality def: "A monadic quality of continuant that exists at the cellular level of organisation." [PATOC:GVG] is_a: PATO:0001241 ! physical object quality property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001404 name: nucleate quality namespace: quality def: "A cellular quality inhering in a bearer by virtue of bearer's number of nuclei." [PATOC:GVG] subset: attribute_slim is_a: PATO:0001396 ! cellular quality property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001406 name: binucleate namespace: quality def: "A nucleate quality inhering in a bearer by virtue of the bearer's having two nuclei." [Biology-online:Biology-online] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0001908 ! multinucleate property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001407 name: mononucleate namespace: quality def: "A nucleate quality inhering in a bearer by virtue of the bearer's having one nucleus." [Biology-online:Biology-online] subset: cell_quality subset: mpath_slim subset: value_slim is_a: PATO:0002505 ! nucleated property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001435 name: attachment quality namespace: quality def: "A structural quality inhering in a bearer by virtue of the bearer's having connection or association with another entity." [PATOC:GVG] subset: attribute_slim subset: relational_slim is_a: PATO:0000141 ! structure property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001442 name: wholeness namespace: quality def: "A structural quality inhering in a bearer by virtue of whether the bearer includes all its components." [thefreedictionary.com:thefreedictionary.com] subset: attribute_slim is_a: PATO:0000141 ! structure property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001444 name: broken namespace: quality alt_id: PATO:0001443 alt_id: PATO:0001820 def: "A broken quality inhering in a bearer by virtue of the bearer's being broken open." [PATOC:GVG] subset: value_slim synonym: "burst" EXACT [] synonym: "cracked" RELATED [] synonym: "fractured" EXACT [] synonym: "fragmented" EXACT [] synonym: "hemorrhaged" RELATED [] synonym: "ruptured" EXACT [] synonym: "split" RELATED [] synonym: "torn" RELATED [] is_a: PATO:0001442 ! wholeness property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001453 name: detached from namespace: quality def: "An attachment quality inhering in a bearer by virtue of the bearer's lacking connection or association with another entity." [PATOC:GVG] subset: mpath_slim subset: relational_slim subset: value_slim synonym: "detached" EXACT [] is_a: PATO:0001435 ! attachment quality property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001457 name: sensitivity of a process namespace: quality def: "A quality of a process inhering in bearer by virtue of the bearer's disposition to respond to stimulation." [PATOC:GVG] subset: attribute_slim subset: disposition_slim subset: relational_slim synonym: "sensitivity of occurrent" EXACT [] is_a: PATO:0002062 ! physical quality of a process property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001499 name: spherical namespace: quality alt_id: PATO:0000408 def: "A spheroid quality inhering in a bearer by virtue of the bearer's resembling a ball (a sphere whose equatorial diameter is equal to the polar diameter)." [WordNet:WordNet] subset: cell_quality subset: mpath_slim subset: value_slim synonym: "globular" EXACT [] synonym: "rotund" RELATED [] is_a: PATO:0001865 ! spheroid relationship: has_cross_section PATO:0000411 ! circular property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001514 name: delaminated namespace: quality def: "A structural quality inhering in a bearer by virtue of the bearer's lacking some outer layer." [PATOC:cjm] subset: mpath_slim subset: value_slim is_a: PATO:0000141 ! structure property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001551 name: increased sensitivity of a process namespace: quality def: "A sensitivity of a process which is higher than normal or average." [PATO:GVG] subset: relational_slim subset: value_slim synonym: "high sensitivity of occurrent" EXACT [] synonym: "increased sensitivity of occurrent" EXACT [] is_a: PATO:0001457 ! sensitivity of a process is_a: PATO:0002304 ! increased process quality intersection_of: PATO:0001457 ! sensitivity of a process intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: increased_in_magnitude_relative_to PATO:0000461 ! normal property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001552 name: decreased sensitivity of a process namespace: quality def: "A sensitivity of a process which is lower than normal or average." [PATO:GVG] subset: relational_slim subset: value_slim synonym: "decreased sensitivity of occurrent" EXACT [] synonym: "low sensitivity of occurrent" EXACT [] is_a: PATO:0001457 ! sensitivity of a process is_a: PATO:0002302 ! decreased process quality intersection_of: PATO:0001457 ! sensitivity of a process intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: decreased_in_magnitude_relative_to PATO:0000461 ! normal property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001555 name: has number of namespace: quality def: "The number of parts of a particular type that the bearer entity has. This is a relational quality, and thus holds between two entities: the bearer of the quality, and the type of parts." [PATOC:CJM] subset: attribute_slim subset: relational_slim synonym: "cardinality" RELATED [] synonym: "extra or missing physical or functional parts" EXACT [] synonym: "has or lacks parts of type" EXACT [] synonym: "mereological quality" EXACT [] synonym: "number" RELATED [] synonym: "number of" EXACT [] xref: OBO_REL:has_part is_a: PATO:0001241 ! physical object quality property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001558 name: lacking processual parts namespace: quality def: "A quality of a process inhering in a bearer by virtue of the bearer's lacking a processual part as specified by the additional entity." [PATOC:GVG] subset: relational_slim subset: value_slim is_a: PATO:0001564 ! extra or missing processual parts property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001561 name: having extra processual parts namespace: quality def: "A quality of a process inhering in a bearer by virtue of the bearer's having additional processual parts." [PATOC:GVG] subset: relational_slim subset: value_slim synonym: "having supernumerary processual parts" EXACT [] is_a: PATO:0001564 ! extra or missing processual parts property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001564 name: extra or missing processual parts namespace: quality def: "A quality of a process inhering in a bearer by virtue of the bearer's processual parts." [PATOC:GVG] subset: relational_slim is_a: PATO:0001236 ! process quality property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001591 name: curvature namespace: quality def: "A surface shape quality inhering in a bearer by virtue of the bearer's exhibiting a degree of bending." [WordNet:WordNet] subset: attribute_slim is_a: PATO:0000052 ! shape property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001598 name: protruding namespace: quality alt_id: PATO:0001644 def: "A quality inhering in a bearer by virtue of the bearer's extending out above or beyond a surface or boundary." [WordNet:WordNet] subset: value_slim synonym: "protruding " EXACT [] synonym: "relational protruding quality" EXACT [] is_a: PATO:0000140 ! position property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001629 name: aggregated namespace: quality def: "A spatial pattern inhering in a bearer by virtue of the bearer's being gathered or tending to gather into a mass or whole." [WordNet:WordNet] subset: mpath_slim subset: value_slim synonym: "clumped" EXACT [] synonym: "clustered" EXACT [] is_a: PATO:0000330 ! irregular spatial pattern property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001630 name: dispersed namespace: quality def: "A positional quality inhering in a bearer by virtue of the bearer's being distributed or spread over a considerable extent." [WordNet:WordNet] subset: mpath_slim subset: value_slim is_a: PATO:0000140 ! position property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001643 name: stubby namespace: quality def: "A size quality inhering in a bearer by virtue of the bearer's having a short, stocky build." [thefreedictionary.com:thefreedictionary.com] subset: value_slim is_a: PATO:0000052 ! shape property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001708 name: 1-D extent namespace: quality def: "A size quality inhering in an bearer by virtue of the bearer's extension in one dimension." [PATOC:GVG] subset: attribute_slim synonym: "1-D size" EXACT [] is_a: PATO:0000117 ! size property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001710 name: 3-D extent namespace: quality def: "A size quality inhering in an bearer by virtue of the bearer's extension in three dimensions." [PATOC:GVG] subset: attribute_slim synonym: "3D size" EXACT [] is_a: PATO:0000117 ! size property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001786 name: split namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's being divided or broken up into parts or divisions." [die.net:die.net] subset: mpath_slim subset: value_slim synonym: "clefted" EXACT [] synonym: "divided" RELATED [] synonym: "forked" RELATED [] synonym: "septate" NARROW [] is_a: PATO:0000052 ! shape property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001798 name: kinked namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's having multiple angles in its length." [thefreedictionary.com:thefreedictionary.com] subset: cell_quality subset: value_slim synonym: "tightly curled" RELATED [] synonym: "twisted" RELATED [] is_a: PATO:0000617 ! bent property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001847 name: constricted namespace: quality alt_id: PATO:0001837 def: "A structural quality inhering in a bearer by virtue of the bearer's being drawn together, compressed or squeezed physically." [WordNet:WordNet] subset: value_slim synonym: "stenosis" EXACT [] synonym: "stenotic" EXACT [] synonym: "stricture" EXACT [] is_a: PATO:0000141 ! structure property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001857 name: concave namespace: quality def: "A shape quality in a bearer by virtue of the bearer's curving inward." [WordNet:WordNet] subset: cell_quality subset: value_slim is_a: PATO:0002005 ! concavity property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001865 name: spheroid namespace: quality alt_id: PATO:0001864 def: "A convex 3-D shape quality inhering in a bearer by virtue of the bearer's having a quadric surface in three dimensions obtained by rotating an ellipse about one of its principal axes. Includes spheres and oblate/prolate spheroids." [Wikipedia:http\://en.wikipedia.org/wiki/Spheroid] subset: cell_quality subset: mpath_slim subset: value_slim synonym: "sphericality" RELATED [] is_a: PATO:0002007 ! convex 3-D shape property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001878 name: sigmoid namespace: quality def: "A shape quality inhering in a bearer by virtue of the bearer's consisting of two curves, in opposite directions. S-shaped." [PATOC:CJM] subset: cell_quality subset: value_slim synonym: "S-shaped" EXACT [] synonym: "sigmoidal" EXACT [] is_a: PATO:0000052 ! shape property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001905 name: has normal numbers of parts of type namespace: quality def: "The bearer of this quality has_part = n, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part." [PATOC:CJM] subset: relational_slim synonym: "having physical part" EXACT [] is_a: PATO:0001555 ! has number of property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001908 name: multinucleate namespace: quality def: "A nucleate quality inhering in a bearer by virtue of the bearer's having more than one nucleus." [PATOC:GVG] subset: mpath_slim subset: value_slim is_a: PATO:0002505 ! nucleated property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001925 name: surface feature shape namespace: quality def: "A surface shape quality inhering in a bearer by virtue of the bearer's shape of features present on its surface or outer shell." [PATOC:CJM] comment: This quality either inheres directly in the surface, or in the entity that has the surface. For example, to say that a particular fly wing is curved is shorthand for saying the wing has a surface which is curved. subset: attribute_slim is_a: PATO:0000052 ! shape property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001995 name: organismal quality namespace: quality def: "A quality that inheres in an entire organism or part of an organism." [PATOC:CJM] is_a: PATO:0001241 ! physical object quality property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0001999 name: lacks parts or has fewer parts of type namespace: quality def: "The bearer of this quality has_part < n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly. This case includes the limit case, where the bearer lacks all parts of the specified type." [PATOC:CJM] subset: relational_slim synonym: "loss of" EXACT [] is_a: PATO:0002083 ! altered number of property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0002000 name: lacks all parts of type namespace: quality alt_id: PATO:0001557 def: "A quality of physical entities inhering in a bearer by virtue of the bearer's lacking a physical part as specified by the additional entity." [PATOC:CJM] comment: Example: [E=organism Q=lacks_all_parts_of_type E2=Wing] - applies to an organism. A relational quality in which the bearer entity has no parts of the specified type. The bearer of this quality has_part = 0 of the indicated entity type, where a comparable organism usually has at least 1 part of the same type. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e lacks all parts of type X at time t, then there exists no instances x of X at t such that x part_of e that has no wings, where wings are normally present in that organism type. In OWL this is equivalent to a restriction on the OBO_REL:has_part relation with cardinality=0, i.e has_part 0 E2. subset: relational_slim synonym: "lacks all physical parts of type" EXACT [] xref: OBO_REL:lacks_part is_a: PATO:0001999 ! lacks parts or has fewer parts of type property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0002001 name: has fewer parts of type namespace: quality alt_id: PATO:0001569 def: "The bearer of this quality has_part < n AND has_part > 0 of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part. Formally: If a bearer entity e has fewer parts of type X at time t, then the number of instances x of X at t such that x part_of e is < n, where n is either the normal number for comparable entities, or n is stated explicitly." [PATOC:CJM] comment: Example: [E=hand Q=has_fewer_parts_of_type E2=digit] - applies to an organism that has no less fingers than is normal for organisms of that type. subset: relational_slim synonym: "decreased number of" EXACT [] synonym: "has decreased number of" EXACT [] synonym: "has fewer physical parts of type" EXACT [] is_a: PATO:0001999 ! lacks parts or has fewer parts of type is_a: PATO:0002303 ! decreased object quality intersection_of: PATO:0001999 ! lacks parts or has fewer parts of type intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: decreased_in_magnitude_relative_to PATO:0000461 ! normal property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0002002 name: has extra parts of type namespace: quality alt_id: PATO:0001560 def: "The bearer of this quality has_part > n of the indicated entity type, where n is the normal amount for a comparable organism. Note that the bearer of the quality is the whole, not the part." [PATOC:CJM] comment: In polydactyly, the bearer of the quality is the hand, and the entity type being counted is 'finger'. In EQ syntax, E=hand, Q= E2=finger. subset: relational_slim synonym: "has extra parts of" EXACT [] synonym: "has increased number of" EXACT [] synonym: "having extra physical parts" EXACT [] synonym: "having supernumerary physical parts" EXACT [] synonym: "increased number of" EXACT [] is_a: PATO:0002083 ! altered number of is_a: PATO:0002305 ! increased object quality intersection_of: PATO:0002083 ! altered number of intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: increased_in_magnitude_relative_to PATO:0000461 ! normal property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0002005 name: concavity namespace: quality def: "Surface shape that refers to the inward or outward curvature of the surface." [PATOC:MAH] subset: attribute_slim is_a: PATO:0000052 ! shape property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0002006 name: 2-D shape namespace: quality def: "A shape that inheres in a 2 dimensional entity, such as a cross section or projection of a 3 dimensional entity." [PATOC:CJM] subset: attribute_slim synonym: "2-D projection" RELATED [] synonym: "cross-sectional" RELATED [] is_a: PATO:0000052 ! shape property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0002007 name: convex 3-D shape namespace: quality def: "A complete three dimensional shape in which for every line connecting pair of points on the object is within the object. Or: a shape lacking cavities. Contrast: concave." [PATOC:CJM] comment: Use this term or an is_a child of this term when the entire shape of the object is known. subset: attribute_slim xref: Image:http\://upload.wikimedia.org/wikipedia/commons/0/06/Convex_polygon_illustration1.png is_a: PATO:0002266 ! 3-D shape relationship: has_cross_section PATO:0002006 ! 2-D shape property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0002008 name: concave 3-D shape namespace: quality def: "A complete three dimensional shape in which there is a line connecting pair of points on the object that lies outside the object. Or: a shape with cavities. Contrast: concave." [PATOC:CJM] subset: attribute_slim xref: Image:http\://en.wikipedia.org/wiki/Image\:Convex_polygon_illustration2.png is_a: PATO:0002266 ! 3-D shape relationship: has_part PATO:0001857 ! concave property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0002009 name: branchiness namespace: quality def: "A shape quality inhering in a bearer by virtue of the degree to which there are subdivisions or offshoots in a bearer entity." [PATOC:MAH] subset: attribute_slim subset: cell_quality is_a: PATO:0000052 ! shape property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0002014 name: structure, cavities namespace: quality def: "A structural quality that inheres in a bearer by virtue of the bearer's containing hollow areas." [PATOC:GVG] subset: attribute_slim is_a: PATO:0000141 ! structure property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Term] id: PATO:0002051 name: increased occurrence namespace: quality def: "An occurrence which is relatively high." [PATOC:GVG] synonym: "increased incidence" EXACT [] is_a: PATO:0000057 ! occurrence is_a: PATO:0002304 ! increased process quality intersection_of: PATO:0000057 ! occurrence intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: increased_in_magnitude_relative_to PATO:0000461 ! normal property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl created_by: George Gkoutos creation_date: 2009-03-26T11:10:11Z [Term] id: PATO:0002052 name: decreased occurrence namespace: quality def: "An occurrence which is relatively low." [PATOC:GVG] synonym: "decreased incidence" EXACT [] is_a: PATO:0000057 ! occurrence is_a: PATO:0002302 ! decreased process quality intersection_of: PATO:0000057 ! occurrence intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: decreased_in_magnitude_relative_to PATO:0000461 ! normal property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl created_by: George Gkoutos creation_date: 2009-03-26T11:12:35Z [Term] id: PATO:0002062 name: physical quality of a process namespace: quality subset: attribute_slim is_a: PATO:0001236 ! process quality property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl created_by: george creation_date: 2009-06-05T09:16:46Z [Term] id: PATO:0002083 name: altered number of namespace: quality def: "Having extra or fewer parts." [PATOC:GVG] subset: attribute_slim subset: relational_slim is_a: PATO:0001555 ! has number of property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl created_by: George Gkoutos creation_date: 2009-09-21T10:41:58Z [Term] id: PATO:0002112 name: perforate namespace: quality alt_id: PATO:0000649 def: "A structural quality inhering in a bearer by virtue of the bearer's having a hole or holes, especially a row or array of small holes." [answers.com:answers.com] subset: mpath_slim subset: value_slim synonym: "permeable" RELATED [] synonym: "pierced" RELATED [] is_a: PATO:0002014 ! structure, cavities property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl created_by: george creation_date: 2009-10-05T03:37:05Z [Term] id: PATO:0002181 name: displaced namespace: quality def: "A positional quality inhering in a bearer by virtue the bearer's being changed in position." [PATOC:GVG] subset: attribute_slim is_a: PATO:0000140 ! position property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl created_by: George Gkoutos creation_date: 2010-03-01T02:56:33Z [Term] id: PATO:0002182 name: molecular quality namespace: quality alt_id: PATO:0002061 def: "A quality which inheres in a molecular entity, a single molecule, atom, ion, radical etc." [PATOC:GVG] synonym: "relational molecular quality" EXACT [] is_a: PATO:0001241 ! physical object quality property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl created_by: George Gkoutos creation_date: 2010-03-10T03:18:15Z [Term] id: PATO:0002213 name: obclavate namespace: quality def: "A concave 3-D shape quality inhering in a bearer by virtue of the bearer's shape being inversely clavate." [PATOC:GVG] subset: cell_quality subset: value_slim is_a: PATO:0002008 ! concave 3-D shape property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl created_by: george creation_date: 2010-07-08T01:47:09Z [Term] id: PATO:0002240 name: teardrop-shaped namespace: quality def: "A convex 3-D shape quality inhering in a bearer by virtue of the bearer's shape resembling falling drop." [url:wordnetweb.princeton.edu/perl/webwn] subset: value_slim synonym: "drop shaped" EXACT [] is_a: PATO:0002007 ! convex 3-D shape property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl created_by: george creation_date: 2010-07-23T02:31:11Z [Term] id: PATO:0002266 name: 3-D shape namespace: quality def: "A shape that inheres in a 3 dimensional entity." [PATOC:OREGON] is_a: PATO:0000052 ! shape property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl created_by: george creation_date: 2010-10-05T12:31:16Z [Term] id: PATO:0002300 name: increased quality namespace: quality def: "A quality that has a value that is increased compared to normal or average." [PATOC:GVG] is_a: PATO:0000069 ! deviation(from_normal) intersection_of: PATO:0000001 ! quality intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: increased_in_magnitude_relative_to PATO:0000461 ! normal property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl created_by: George Gkoutos creation_date: 2011-06-16T06:39:43Z [Term] id: PATO:0002301 name: decreased quality namespace: quality def: "A quality that has a value that is decreased compared to normal or average." [PATOC:GVG] is_a: PATO:0000069 ! deviation(from_normal) intersection_of: PATO:0000001 ! quality intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: decreased_in_magnitude_relative_to PATO:0000461 ! normal property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl created_by: George Gkoutos creation_date: 2011-06-16T06:40:15Z [Term] id: PATO:0002302 name: decreased process quality namespace: quality def: "A quality of a process that has a value that is decreased compared to normal or average." [PATOC:GVG] is_a: PATO:0001236 ! process quality is_a: PATO:0002301 ! decreased quality intersection_of: PATO:0001236 ! process quality intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: decreased_in_magnitude_relative_to PATO:0000461 ! normal property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl created_by: George Gkoutos creation_date: 2011-06-16T06:50:59Z [Term] id: PATO:0002303 name: decreased object quality namespace: quality def: "A quality of an object that has a value that is decreased compared to normal or average." [PATOC:GVG] is_a: PATO:0001241 ! physical object quality is_a: PATO:0002301 ! decreased quality intersection_of: PATO:0001241 ! physical object quality intersection_of: decreased_in_magnitude_relative_to PATO:0000461 ! normal relationship: decreased_in_magnitude_relative_to PATO:0000461 ! normal property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl created_by: George Gkoutos creation_date: 2011-06-16T06:51:54Z [Term] id: PATO:0002304 name: increased process quality namespace: quality def: "A quality of a process that has a value that is increased compared to normal or average." [PATOC:GVG] is_a: PATO:0001236 ! process quality is_a: PATO:0002300 ! increased quality intersection_of: PATO:0001236 ! process quality intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: increased_in_magnitude_relative_to PATO:0000461 ! normal property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl created_by: George Gkoutos creation_date: 2011-06-16T06:53:08Z [Term] id: PATO:0002305 name: increased object quality namespace: quality def: "A quality of an object that has a value that is increased compared to normal or average." [PATOC:GVG] is_a: PATO:0001241 ! physical object quality is_a: PATO:0002300 ! increased quality intersection_of: PATO:0001241 ! physical object quality intersection_of: increased_in_magnitude_relative_to PATO:0000461 ! normal relationship: increased_in_magnitude_relative_to PATO:0000461 ! normal property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl created_by: George Gkoutos creation_date: 2011-06-16T06:54:01Z [Term] id: PATO:0002318 name: superelliptic namespace: quality def: "A shape constituting a transition between a rectangle and a circle; a closed curve, of which the circle and ellipse are special cases, whose parametric equation is x = a.cos2/rt, y = b.cos2/rt" [wiktionary:superellipse] synonym: "Lamé curve" EXACT [] is_a: PATO:0002006 ! 2-D shape property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl created_by: George Gkoutos creation_date: 2011-10-12T12:45:16Z [Term] id: PATO:0002323 name: temporal distribution quality namespace: quality def: "A temporal distribution pattern of process occurrences within a regulation/reference process." [PATOC:LC] subset: attribute_slim is_a: PATO:0002062 ! physical quality of a process property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl created_by: George Gkoutos creation_date: 2011-11-22T01:12:28Z [Term] id: PATO:0002325 name: onset quality namespace: quality def: "The temporal relation between the start of the process with respect to a reference process." [PATOC:LC] subset: attribute_slim is_a: PATO:0002323 ! temporal distribution quality property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl created_by: George Gkoutos creation_date: 2011-11-23T11:47:34Z [Term] id: PATO:0002345 name: lemon-shaped namespace: quality def: "A convex 3-D shape quality inhering in a bearer by virtue of the bearer's having a quadric surface in three dimensions obtained by rotating less than half of a circular arc about an axis passing through the endpoints of the arc" [PATOC:MH] subset: value_slim is_a: PATO:0002007 ! convex 3-D shape property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl created_by: gkoutos creation_date: 2012-01-31T03:55:16Z [Term] id: PATO:0002346 name: snowman-shaped namespace: quality def: "A concave 3-D shape quality inhering in a bearer by virtue of the bearer's having two connected parts, roughly spherical, of different sizes." [PATOC:MH] subset: value_slim is_a: PATO:0002008 ! concave 3-D shape property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl created_by: gkoutos creation_date: 2012-01-31T03:58:10Z [Term] id: PATO:0002505 name: nucleated namespace: quality def: "A nucleate quality inhering in a bearer by virtue of the bearer's having one or more nucleus." [PATOC:GVG] subset: mpath_slim subset: value_slim is_a: PATO:0001404 ! nucleate quality property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl created_by: gkoutos creation_date: 2013-10-21T05:44:34Z [Term] id: SO:0000001 name: region namespace: sequence def: "A sequence_feature with an extent greater than zero. A nucleotide region is composed of bases and a polypeptide region is composed of amino acids." [SO:ke] subset: SOFA synonym: "sequence" EXACT [] is_a: SO:0000110 ! sequence_feature property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000010 name: protein_coding namespace: sequence synonym: "protein-coding" EXACT [] is_a: SO:0000401 ! gene_attribute property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000011 name: non_protein_coding namespace: sequence synonym: "non protein-coding" EXACT [] is_a: SO:0000401 ! gene_attribute property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000101 name: transposable_element namespace: sequence def: "A transposon or insertion sequence. An element that can insert in a variety of DNA sequences." [http://www.sci.sdsu.edu/~smaloy/Glossary/T.html] subset: SOFA synonym: "transposable element" EXACT [] synonym: "transposon" EXACT [] xref: http://en.wikipedia.org/wiki/Transposable_element "wiki" is_a: SO:0001039 ! integrated_mobile_genetic_element property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000110 name: sequence_feature namespace: sequence def: "Any extent of continuous biological sequence." [LAMHDI:mb, SO:ke] subset: SOFA synonym: "located sequence feature" RELATED [] synonym: "located_sequence_feature" EXACT [] synonym: "sequence feature" EXACT [] disjoint_from: SO:0000400 ! sequence_attribute property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000162 name: splice_site namespace: sequence def: "Consensus region of primary transcript bordering junction of splicing. A region that overlaps exactly 2 base and adjacent_to splice_junction." [SO:cjm, SO:ke] comment: With spliceosomal introns, the splice sites bind the spliceosomal machinery. subset: SOFA synonym: "splice site" EXACT [] xref: http://en.wikipedia.org/wiki/Splice_site "wiki" is_a: SO:0000835 ! primary_transcript_region property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000180 name: retrotransposon namespace: sequence def: "A transposable element that is incorporated into a chromosome by a mechanism that requires reverse transcriptase." [http://www.dddmag.com/Glossary.aspx#r] synonym: "class I" RELATED [] synonym: "class I transposon" EXACT [] synonym: "retrotransposon element" EXACT [] xref: http://en.wikipedia.org/wiki/Retrotransposon "wiki" is_a: SO:0000101 ! transposable_element property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000185 name: primary_transcript namespace: sequence def: "A transcript that in its initial state requires modification to be functional." [SO:ma] subset: SOFA synonym: "precursor RNA" EXACT [] synonym: "primary transcript" EXACT [] xref: http://en.wikipedia.org/wiki/Primary_transcript "wiki" is_a: SO:0000673 ! transcript property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000186 name: LTR_retrotransposon namespace: sequence def: "A retrotransposon flanked by long terminal repeat sequences." [SO:ke] synonym: "long terminal repeat retrotransposon" EXACT [] synonym: "LTR retrotransposon" EXACT [] is_a: SO:0000180 ! retrotransposon property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000188 name: intron namespace: sequence def: "A region of a primary transcript that is transcribed, but removed from within the transcript by splicing together the sequences (exons) on either side of it." [http://www.ebi.ac.uk/embl/Documentation/FT_definitions/feature_table.html] comment: This term is mapped to MGED. Do not obsolete without consulting MGED ontology. subset: SOFA xref: http://en.wikipedia.org/wiki/Intron "wiki" is_a: SO:0000835 ! primary_transcript_region property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000209 name: rRNA_primary_transcript namespace: sequence def: "A primary transcript encoding a ribosomal RNA." [SO:ke] subset: SOFA synonym: "ribosomal RNA primary transcript" EXACT [] synonym: "rRNA primary transcript" EXACT [] is_a: SO:0000483 ! nc_primary_transcript property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000210 name: tRNA_primary_transcript namespace: sequence def: "A primary transcript encoding a transfer RNA (SO:0000253)." [SO:ke] synonym: "tRNA primary transcript" EXACT [] is_a: SO:0000483 ! nc_primary_transcript property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000231 name: snRNA_primary_transcript namespace: sequence def: "A primary transcript encoding a small nuclear RNA (SO:0000274)." [SO:ke] synonym: "snRNA primary transcript" EXACT [] is_a: SO:0000483 ! nc_primary_transcript property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000232 name: snoRNA_primary_transcript namespace: sequence def: "A primary transcript encoding a small nucleolar mRNA (SO:0000275)." [SO:ke] synonym: "snoRNA primary transcript" EXACT [] is_a: SO:0000483 ! nc_primary_transcript property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000233 name: mature_transcript namespace: sequence def: "A transcript which has undergone the necessary modifications, if any, for its function. In eukaryotes this includes, for example, processing of introns, cleavage, base modification, and modifications to the 5' and/or the 3' ends, other than addition of bases. In bacteria functional mRNAs are usually not modified." [SO:ke] comment: A processed transcript cannot contain introns. subset: SOFA synonym: "mature transcript" EXACT [] xref: http://en.wikipedia.org/wiki/Mature_transcript "wiki" is_a: SO:0000673 ! transcript relationship: derives_from SO:0000185 ! primary_transcript property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000234 name: mRNA namespace: sequence def: "Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns." [SO:ma] comment: An mRNA does not contain introns as it is a processed_transcript. The equivalent kind of primary_transcript is protein_coding_primary_transcript (SO:0000120) which may contain introns. This term is mapped to MGED. Do not obsolete without consulting MGED ontology. subset: SOFA synonym: "messenger RNA" EXACT [] xref: http://en.wikipedia.org/wiki/MRNA "wiki" is_a: SO:0000233 ! mature_transcript property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000235 name: TF_binding_site namespace: sequence def: "A region of a nucleotide molecule that binds a Transcription Factor or Transcription Factor complex [GO:0005667]." [SO:ke] subset: SOFA synonym: "TF binding site" EXACT [] synonym: "transcription factor binding site" EXACT [] is_a: SO:0001654 ! nucleotide_to_protein_binding_site is_a: SO:0001679 ! transcription_regulatory_region property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000237 name: transcript_attribute namespace: sequence synonym: "transcript attribute" EXACT [] is_a: SO:0000733 ! feature_attribute property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000246 name: polyadenylated namespace: sequence def: "A attribute describing the addition of a poly A tail to the 3' end of a mRNA molecule." [SO:ke] is_a: SO:0000863 ! mRNA_attribute property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000252 name: rRNA namespace: sequence def: "RNA that comprises part of a ribosome, and that can provide both structural scaffolding and catalytic activity." [http://www.ebi.ac.uk/embl/Documentation/FT_definitions/feature_table.html, ISBN:0198506732] subset: SOFA synonym: "ribosomal ribonucleic acid" EXACT [] synonym: "ribosomal RNA" EXACT [] xref: http://en.wikipedia.org/wiki/RRNA "wiki" is_a: SO:0000655 ! ncRNA relationship: derives_from SO:0000209 ! rRNA_primary_transcript property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000253 name: tRNA namespace: sequence def: "Transfer RNA (tRNA) molecules are approximately 80 nucleotides in length. Their secondary structure includes four short double-helical elements and three loops (D, anti-codon, and T loops). Further hydrogen bonds mediate the characteristic L-shaped molecular structure. Transfer RNAs have two regions of fundamental functional importance: the anti-codon, which is responsible for specific mRNA codon recognition, and the 3' end, to which the tRNA's corresponding amino acid is attached (by aminoacyl-tRNA synthetases). Transfer RNAs cope with the degeneracy of the genetic code in two manners: having more than one tRNA (with a specific anti-codon) for a particular amino acid; and 'wobble' base-pairing, i.e. permitting non-standard base-pairing at the 3rd anti-codon position." [http://www.sanger.ac.uk/cgi-bin/Rfam/getacc?RF00005, ISBN:0198506732] comment: This term is mapped to MGED. Do not obsolete without consulting MGED ontology. subset: SOFA synonym: "transfer ribonucleic acid" RELATED [] synonym: "transfer RNA" RELATED [] xref: http://en.wikipedia.org/wiki/TRNA "wiki" is_a: SO:0000655 ! ncRNA relationship: derives_from SO:0000210 ! tRNA_primary_transcript property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000255 name: rRNA_small_subunit_primary_transcript namespace: sequence def: "A primary transcript encoding a small ribosomal subunit RNA." [SO:ke] synonym: "rRNA small subunit primary transcript" EXACT [] is_a: SO:0000209 ! rRNA_primary_transcript property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000274 name: snRNA namespace: sequence def: "A small nuclear RNA molecule involved in pre-mRNA splicing and processing." [http://www.ebi.ac.uk/embl/Documentation/FT_definitions/feature_table.html, PMID:11733745, WB:ems] comment: This term is mapped to MGED. Do not obsolete without consulting MGED ontology. subset: SOFA synonym: "small nuclear RNA" EXACT [] xref: http://en.wikipedia.org/wiki/SnRNA "wiki" is_a: SO:0000655 ! ncRNA relationship: derives_from SO:0000231 ! snRNA_primary_transcript property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000275 name: snoRNA namespace: sequence def: "A snoRNA (small nucleolar RNA) is any one of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. They participate in the processing or modifications of many RNAs, mostly ribosomal RNAs (rRNAs) though snoRNAs are also known to target other classes of RNA, including spliceosomal RNAs, tRNAs, and mRNAs via a stretch of sequence that is complementary to a sequence in the targeted RNA." [GOC:kgc] subset: SOFA synonym: "small nucleolar RNA" EXACT [] xref: http://en.wikipedia.org/wiki/SnoRNA "wiki" is_a: SO:0000655 ! ncRNA relationship: derives_from SO:0000232 ! snoRNA_primary_transcript property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000286 name: long_terminal_repeat namespace: sequence def: "A sequence directly repeated at both ends of a defined sequence, of the sort typically found in retroviruses." [http://www.ebi.ac.uk/embl/Documentation/FT_definitions/feature_table.html] synonym: "direct terminal repeat" RELATED [] synonym: "long terminal repeat" EXACT [] synonym: "LTR" EXACT [] xref: http://en.wikipedia.org/wiki/Long_terminal_repeat "wiki" is_a: SO:0000657 ! repeat_region relationship: part_of SO:0000186 ! LTR_retrotransposon property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000296 name: origin_of_replication namespace: sequence def: "The origin of replication; starting site for duplication of a nucleic acid molecule to give two identical copies." [http://www.ebi.ac.uk/embl/Documentation/FT_definitions/feature_table.html] subset: SOFA synonym: "ori" EXACT [] synonym: "origin of replication" EXACT [] xref: http://en.wikipedia.org/wiki/Origin_of_replication "wiki" is_a: SO:0001411 ! biological_region relationship: part_of SO:0001235 ! replicon property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000325 name: rRNA_large_subunit_primary_transcript namespace: sequence def: "A primary transcript encoding a large ribosomal subunit RNA." [SO:ke] subset: SOFA synonym: "35S rRNA primary transcript" EXACT [] synonym: "rRNA large subunit primary transcript" EXACT [] is_a: SO:0000209 ! rRNA_primary_transcript property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000330 name: conserved_region namespace: sequence def: "Region of sequence similarity by descent from a common ancestor." [SO:ke] subset: SOFA synonym: "conserved region" EXACT [] xref: http://en.wikipedia.org/wiki/Conserved_region "wiki" is_a: SO:0001410 ! experimental_feature property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000340 name: chromosome namespace: sequence def: "Structural unit composed of a nucleic acid molecule which controls its own replication through the interaction of specific proteins at one or more origins of replication." [SO:ma] comment: This term is mapped to MGED. Do not obsolete without consulting MGED ontology. subset: SOFA xref: http://en.wikipedia.org/wiki/Chromosome "wiki" is_a: SO:0001235 ! replicon property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000375 name: rRNA_5_8S namespace: sequence def: "5_8S ribosomal RNA (5. 8S rRNA) is a component of the large subunit of the eukaryotic ribosome. It is transcribed by RNA polymerase I as part of the 45S precursor that also contains 18S and 28S rRNA. Functionally, it is thought that 5.8S rRNA may be involved in ribosome translocation. It is also known to form covalent linkage to the p53 tumour suppressor protein. 5_8S rRNA is also found in archaea." [http://www.sanger.ac.uk/cgi-bin/Rfam/getacc?RF00002] subset: SOFA synonym: "5.8S LSU rRNA" EXACT [] synonym: "5.8S ribosomal RNA" EXACT [] synonym: "5.8S rRNA" EXACT [] synonym: "rRNA 5 8S" EXACT [] xref: http://en.wikipedia.org/wiki/5.8S_ribosomal_RNA "wiki" is_a: SO:0000651 ! large_subunit_rRNA property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000400 name: sequence_attribute namespace: sequence def: "An attribute describes a quality of sequence." [SO:ke] synonym: "sequence attribute" EXACT [] property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000401 name: gene_attribute namespace: sequence synonym: "gene attribute" EXACT [] is_a: SO:0000733 ! feature_attribute property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000407 name: rRNA_18S namespace: sequence def: "A large polynucleotide in eukaryotes, which functions as the small subunit of the ribosome." [SO:ke] subset: SOFA synonym: "18S ribosomal RNA" EXACT [] synonym: "18S rRNA" EXACT [] synonym: "rRNA 18S" EXACT [] xref: http://en.wikipedia.org/wiki/18S_ribosomal_RNA "wiki" is_a: SO:0000650 ! small_subunit_rRNA property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000409 name: binding_site namespace: sequence alt_id: BS:00033 def: "A biological_region of sequence that, in the molecule, interacts selectively and non-covalently with other molecules. A region on the surface of a molecule that may interact with another molecule. When applied to polypeptides: Amino acids involved in binding or interactions. It can also apply to an amino acid bond which is represented by the positions of the two flanking amino acids." [EBIBS:GAR, SO:ke] comment: See GO:0005488 : binding. subset: biosapiens subset: SOFA synonym: "binding_or_interaction_site" EXACT [] synonym: "site" RELATED [] xref: http://en.wikipedia.org/wiki/Binding_site "wiki" is_a: SO:0001411 ! biological_region property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000410 name: protein_binding_site namespace: sequence def: "A binding site that, in the molecule, interacts selectively and non-covalently with polypeptide molecules." [SO:ke] comment: See GO:0042277 : peptide binding. subset: SOFA synonym: "protein binding site" EXACT [] is_a: SO:0000409 ! binding_site property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000483 name: nc_primary_transcript namespace: sequence def: "A primary transcript that is never translated into a protein." [SO:ke] subset: SOFA synonym: "nc primary transcript" EXACT [] synonym: "noncoding primary transcript" EXACT [] is_a: SO:0000185 ! primary_transcript property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000577 name: centromere namespace: sequence def: "A region of chromosome where the spindle fibers attach during mitosis and meiosis." [SO:ke] subset: SOFA xref: http://en.wikipedia.org/wiki/Centromere "wiki" is_a: SO:0000628 ! chromosomal_structural_element property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000605 name: intergenic_region namespace: sequence def: "A region containing or overlapping no genes that is bounded on either side by a gene, or bounded by a gene and the end of the chromosome." [SO:cjm] comment: This term is mapped to MGED. Do not obsolete without consulting MGED ontology. subset: SOFA synonym: "intergenic region" EXACT [] xref: http://en.wikipedia.org/wiki/Intergenic_region "wiki" is_a: SO:0001411 ! biological_region property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000610 name: polyA_sequence namespace: sequence def: "Sequence of about 100 nucleotides of A added to the 3' end of most eukaryotic mRNAs." [SO:ke] subset: SOFA synonym: "polyA sequence" EXACT [] is_a: SO:0001411 ! biological_region relationship: adjacent_to SO:0000234 ! mRNA property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000624 name: telomere namespace: sequence def: "A specific structure at the end of a linear chromosome, required for the integrity and maintenance of the end." [SO:ma] subset: SOFA synonym: "telomeric DNA" EXACT [] synonym: "telomeric sequence" EXACT [] xref: http://en.wikipedia.org/wiki/Telomere "wiki" is_a: SO:0000628 ! chromosomal_structural_element property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000628 name: chromosomal_structural_element namespace: sequence subset: SOFA synonym: "chromosomal structural element" EXACT [] is_a: SO:0000830 ! chromosome_part property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000644 name: antisense_RNA namespace: sequence def: "Antisense RNA is RNA that is transcribed from the coding, rather than the template, strand of DNA. It is therefore complementary to mRNA." [SO:ke] subset: SOFA synonym: "antisense RNA" EXACT [] xref: http://en.wikipedia.org/wiki/Antisense_RNA "wiki" is_a: SO:0000655 ! ncRNA relationship: derives_from SO:0000645 ! antisense_primary_transcript property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000645 name: antisense_primary_transcript namespace: sequence def: "The reverse complement of the primary transcript." [SO:ke] subset: SOFA synonym: "antisense primary transcript" EXACT [] is_a: SO:0000185 ! primary_transcript property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000646 name: siRNA namespace: sequence def: "A small RNA molecule that is the product of a longer exogenous or endogenous dsRNA, which is either a bimolecular duplex or very long hairpin, processed (via the Dicer pathway) such that numerous siRNAs accumulate from both strands of the dsRNA. SRNAs trigger the cleavage of their target molecules." [PMID:12592000] subset: SOFA synonym: "small interfering RNA" EXACT [] xref: http://en.wikipedia.org/wiki/SiRNA "wiki" is_a: SO:0000655 ! ncRNA property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000650 name: small_subunit_rRNA namespace: sequence def: "Ribosomal RNA transcript that structures the small subunit of the ribosome." [SO:ke] subset: SOFA synonym: "small subunit rRNA" EXACT [] synonym: "SSU RNA" EXACT [RSC:cb] synonym: "SSU rRNA" EXACT [RSC:cb] is_a: SO:0000252 ! rRNA relationship: derives_from SO:0000255 ! rRNA_small_subunit_primary_transcript property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000651 name: large_subunit_rRNA namespace: sequence def: "Ribosomal RNA transcript that structures the large subunit of the ribosome." [SO:ke] subset: SOFA synonym: "large subunit rRNA" EXACT [] synonym: "LSU RNA" EXACT [RSC:cb] synonym: "LSU rRNA" EXACT [RSC:cb] is_a: SO:0000252 ! rRNA relationship: derives_from SO:0000325 ! rRNA_large_subunit_primary_transcript property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000655 name: ncRNA namespace: sequence def: "An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product." [SO:ke] comment: A ncRNA is a processed_transcript, so it may not contain parts such as transcribed_spacer_regions that are removed in the act of processing. For the corresponding primary_transcripts, please see term SO:0000483 nc_primary_transcript. subset: SOFA synonym: "noncoding RNA" EXACT [] xref: http://en.wikipedia.org/wiki/NcRNA "wiki" is_a: SO:0000233 ! mature_transcript property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000657 name: repeat_region namespace: sequence def: "A region of sequence containing one or more repeat units." [SO:ke] subset: SOFA synonym: "repeat region" EXACT [] is_a: SO:0001411 ! biological_region relationship: has_part SO:0000726 ! repeat_unit property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000663 name: tRNA_encoding namespace: sequence synonym: "tRNA encoding" EXACT [] is_a: SO:0000011 ! non_protein_coding property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000673 name: transcript namespace: sequence def: "An RNA synthesized on a DNA or RNA template by an RNA polymerase." [SO:ma] subset: SOFA xref: http://en.wikipedia.org/wiki/RNA "wiki" is_a: SO:0000831 ! gene_member_region property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000704 name: gene namespace: sequence def: "A region (or regions) that includes all of the sequence elements necessary to encode a functional transcript. A gene may include regulatory regions, transcribed regions and/or other functional sequence regions." [SO:immuno_workshop] comment: This term is mapped to MGED. Do not obsolete without consulting MGED ontology. A gene may be considered as a unit of inheritance. subset: SOFA xref: http://en.wikipedia.org/wiki/Gene "wiki" is_a: SO:0001411 ! biological_region relationship: member_of SO:0005855 ! gene_group property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000713 name: DNA_motif namespace: sequence def: "A motif that is active in the DNA form of the sequence." [SO:ke] synonym: "DNA motif" EXACT [] xref: http://en.wikipedia.org/wiki/DNA_motif "wiki" is_a: SO:0000714 ! nucleotide_motif property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000714 name: nucleotide_motif namespace: sequence def: "A region of nucleotide sequence corresponding to a known motif." [SO:ke] subset: SOFA synonym: "nucleotide motif" EXACT [] is_a: SO:0001683 ! sequence_motif property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000726 name: repeat_unit namespace: sequence def: "The simplest repeated component of a repeat region. A single repeat." [SO:ke] comment: Added to comply with the feature table. A single repeat. synonym: "repeat unit" EXACT [] xref: http://www.ebi.ac.uk/embl/Documentation/FT_definitions/feature_table.html is_a: SO:0001411 ! biological_region property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000733 name: feature_attribute namespace: sequence def: "An attribute describing a located_sequence_feature." [SO:ke] synonym: "feature attribute" EXACT [] is_a: SO:0000400 ! sequence_attribute property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000830 name: chromosome_part namespace: sequence def: "A region of a chromosome." [SO:ke] comment: This is a manufactured term, that serves the purpose of allow the parts of a chromosome to have an is_a path to the root. subset: SOFA synonym: "chromosome part" EXACT [] is_a: SO:0001411 ! biological_region relationship: part_of SO:0000340 ! chromosome property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000831 name: gene_member_region namespace: sequence def: "A region of a gene." [SO:ke] comment: A manufactured term used to allow the parts of a gene to have an is_a path to the root. subset: SOFA synonym: "gene member region" EXACT [] is_a: SO:0001411 ! biological_region relationship: member_of SO:0000704 ! gene property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000833 name: transcript_region namespace: sequence def: "A region of a transcript." [SO:ke] comment: This term was added to provide a grouping term for the region parts of transcript, thus giving them an is_a path back to the root. subset: SOFA synonym: "transcript region" EXACT [] is_a: SO:0001411 ! biological_region relationship: part_of SO:0000673 ! transcript property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000835 name: primary_transcript_region namespace: sequence def: "A part of a primary transcript." [SO:ke] comment: This term was added to provide a grouping term for the region parts of primary_transcript, thus giving them an is_a path back to the root. subset: SOFA synonym: "primary transcript region" EXACT [] is_a: SO:0000833 ! transcript_region relationship: part_of SO:0000185 ! primary_transcript property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000863 name: mRNA_attribute namespace: sequence def: "An attribute describing an mRNA feature." [SO:ke] synonym: "mRNA attribute" EXACT [] is_a: SO:0000237 ! transcript_attribute property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0000871 name: polyadenylated_mRNA namespace: sequence def: "An mRNA that is polyadenylated." [SO:xp] synonym: "polyadenylated mRNA" EXACT [] is_a: SO:0000234 ! mRNA intersection_of: SO:0000234 ! mRNA intersection_of: adjacent_to SO:0000610 ! polyA_sequence intersection_of: has_quality SO:0000246 ! polyadenylated relationship: adjacent_to SO:0000610 ! polyA_sequence relationship: has_quality SO:0000246 ! polyadenylated property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0001002 name: rRNA_25S namespace: sequence def: "A large polynucleotide which functions as part of the large subunit of the ribosome in some eukaryotes." [RSC:cb] subset: SOFA synonym: "25S LSU rRNA" EXACT [] synonym: "25S ribosomal RNA" EXACT [] synonym: "25S rRNA" EXACT [] synonym: "rRNA 25S" EXACT [] is_a: SO:0000651 ! large_subunit_rRNA property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0001037 name: mobile_genetic_element namespace: sequence def: "A nucleotide region with either intra-genome or intracellular mobility, of varying length, which often carry the information necessary for transfer and recombination with the host genome." [PMID:14681355] subset: SOFA synonym: "MGE" EXACT [] synonym: "mobile genetic element" EXACT [] xref: http://en.wikipedia.org/wiki/Mobile_genetic_element "wiki" is_a: SO:0001411 ! biological_region intersection_of: SO:0000001 ! region intersection_of: has_quality SO:0001234 ! mobile relationship: has_quality SO:0001234 ! mobile property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0001039 name: integrated_mobile_genetic_element namespace: sequence def: "An MGE that is integrated into the host chromosome." [SO:ke] subset: SOFA synonym: "integrated mobile genetic element" EXACT [] is_a: SO:0001037 ! mobile_genetic_element property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0001059 name: sequence_alteration namespace: sequence alt_id: SO:1000004 alt_id: SO:1000007 def: "A sequence_alteration is a sequence_feature whose extent is the deviation from another sequence." [SO:ke] comment: Merged with partially characterized change in nucleotide sequence. subset: SOFA synonym: "partially characterised change in DNA sequence" NARROW [] synonym: "partially_characterised_change_in_DNA_sequence" NARROW [] synonym: "sequence alteration" EXACT [] synonym: "sequence variation" RELATED [] synonym: "uncharacterised_change_in_nucleotide_sequence" NARROW [] is_a: SO:0000110 ! sequence_feature property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0001217 name: protein_coding_gene namespace: sequence synonym: "protein coding gene" EXACT [] is_a: SO:0000704 ! gene intersection_of: SO:0000704 ! gene intersection_of: has_quality SO:0000010 ! protein_coding relationship: has_quality SO:0000010 ! protein_coding property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0001234 name: mobile namespace: sequence def: "An attribute describing a feature that has either intra-genome or intracellular mobility." [RSC:cb] xref: http://en.wikipedia.org/wiki/Mobile "wiki" is_a: SO:0000733 ! feature_attribute property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0001235 name: replicon namespace: sequence def: "A region containing at least one unique origin of replication and a unique termination site." [ISBN:0716719207] subset: SOFA xref: http://en.wikipedia.org/wiki/Replicon_(genetics) "wiki" is_a: SO:0001411 ! biological_region property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0001263 name: ncRNA_gene namespace: sequence synonym: "ncRNA gen" EXACT [] synonym: "ncRNA gene" EXACT [] synonym: "non-coding RNA gene" RELATED [] is_a: SO:0000704 ! gene property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0001272 name: tRNA_gene namespace: sequence synonym: "tRNA gene" EXACT [] is_a: SO:0001263 ! ncRNA_gene intersection_of: SO:0001263 ! ncRNA_gene intersection_of: has_quality SO:0000663 ! tRNA_encoding relationship: has_quality SO:0000663 ! tRNA_encoding property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0001410 name: experimental_feature namespace: sequence def: "A region which is the result of some arbitrary experimental procedure. The procedure may be carried out with biological material or inside a computer." [SO:cb] subset: SOFA synonym: "analysis feature" RELATED [] synonym: "experimental output artefact" EXACT [] synonym: "experimental_output_artefact" EXACT [] is_a: SO:0000001 ! region property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0001411 name: biological_region namespace: sequence def: "A region defined by its disposition to be involved in a biological process." [SO:cb] subset: SOFA synonym: "biological region" EXACT [] is_a: SO:0000001 ! region property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0001533 name: cryptic_splice_site namespace: sequence def: "A splice site that is in part of the transcript not normally spliced. They occur via mutation or transcriptional error." [SO:ke] synonym: "cryptic splice signal" RELATED [] synonym: "cryptic splice site" EXACT [] is_a: SO:0000162 ! splice_site property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl created_by: kareneilbeck creation_date: 2010-03-11T03:25:06Z [Term] id: SO:0001637 name: rRNA_gene namespace: sequence def: "A gene that encodes for ribosomal RNA." [SO:ke] synonym: "rDNA" EXACT [] synonym: "rRNA gene" EXACT [] is_a: SO:0001263 ! ncRNA_gene property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl created_by: kareneilbeck creation_date: 2010-04-21T10:10:32Z [Term] id: SO:0001654 name: nucleotide_to_protein_binding_site namespace: sequence def: "A binding site that, in the nucleotide molecule, interacts selectively and non-covalently with polypeptide residues." [SO:ke] subset: SOFA synonym: "nucleotide to protein binding site" RELATED [] is_a: SO:0000410 ! protein_binding_site property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl created_by: kareneilbeck creation_date: 2010-08-03T12:26:05Z [Term] id: SO:0001659 name: promoter_element namespace: sequence synonym: "promoter element" EXACT [] is_a: SO:0000713 ! DNA_motif relationship: overlaps SO:0000235 ! TF_binding_site property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl created_by: kareneilbeck creation_date: 2010-10-01T11:48:32Z [Term] id: SO:0001679 name: transcription_regulatory_region namespace: sequence def: "A regulatory region that is involved in the control of the process of transcription." [SO:ke] subset: SOFA synonym: "transcription regulatory region" EXACT [] is_a: SO:0005836 ! regulatory_region property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl created_by: kareneilbeck creation_date: 2010-10-12T03:49:35Z [Term] id: SO:0001683 name: sequence_motif namespace: sequence def: "A sequence motif is a nucleotide or amino-acid sequence pattern that may have biological significance." [http://en.wikipedia.org/wiki/Sequence_motif] subset: SOFA synonym: "sequence motif" RELATED [] xref: http://en.wikipedia.org/wiki/Sequence_motif "wikipedia" is_a: SO:0001411 ! biological_region property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl created_by: kareneilbeck creation_date: 2010-10-14T04:13:22Z [Term] id: SO:0001789 name: mating_type_region namespace: sequence def: "A specialized region in the genomes of some yeast and fungi, the genes of which regulate mating type." [SO:ke] synonym: "mating type region" EXACT [] xref: http://en.wikipedia.org/wiki/Mating-type_region is_a: SO:0005855 ! gene_group property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl created_by: kareneilbeck creation_date: 2011-04-08T11:14:07Z [Term] id: SO:0001795 name: regional_centromere namespace: sequence def: "A regional centromere is a large modular centromere found in fission yeast and higher eukaryotes. It consist of a central core region flanked by inverted inner and outer repeat regions." [PMID:7502067, SO:vw] synonym: "regional centromere" EXACT [] is_a: SO:0000577 ! centromere property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl created_by: kareneilbeck creation_date: 2011-05-31T12:43:07Z [Term] id: SO:0001796 name: regional_centromere_central_core namespace: sequence def: "A conserved region within the central region of a modular centromere, where the kinetochore is formed." [SO:vw] synonym: "regional centromere central core" EXACT [] is_a: SO:0000330 ! conserved_region relationship: part_of SO:0001795 ! regional_centromere property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl created_by: kareneilbeck creation_date: 2011-05-31T12:56:30Z [Term] id: SO:0001797 name: centromeric_repeat namespace: sequence def: "A repeat region found within the modular centromere." [SO:ke] synonym: "centromeric repeat" EXACT [] is_a: SO:0000657 ! repeat_region property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl created_by: kareneilbeck creation_date: 2011-05-31T12:59:27Z [Term] id: SO:0001798 name: regional_centromere_inner_repeat_region namespace: sequence def: "The inner inverted repeat region of a modular centromere and part of the central core surrounding a non-conserved central region. This region is adjacent to the central core, on each chromosome arm." [SO:vw] synonym: "lmr repeat" EXACT [] synonym: "lmr1L" EXACT [] synonym: "lmr1R" EXACT [] synonym: "regional centromere inner repeat region" EXACT [] is_a: SO:0001797 ! centromeric_repeat relationship: part_of SO:0001796 ! regional_centromere_central_core property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl created_by: kareneilbeck creation_date: 2011-05-31T01:01:08Z [Term] id: SO:0001799 name: regional_centromere_outer_repeat_region namespace: sequence def: "The heterochromatic outer repeat region of a modular centromere. These repeats exist in tandem arrays on both chromosome arms." [SO:vw] synonym: "regional centromere outer repeat region" EXACT [] is_a: SO:0001797 ! centromeric_repeat relationship: part_of SO:0001795 ! regional_centromere property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl created_by: kareneilbeck creation_date: 2011-05-31T01:03:23Z [Term] id: SO:0001855 name: MCB namespace: sequence def: "A promoter element with consensus sequence ACGCGT, bound by the transcription factor complex MBF (MCB-binding factor) and found in promoters of genes expressed during the G1/S transition of the cell cycle." [PMID:16285853] synonym: "MluI cell cycle box" EXACT [] is_a: SO:0001659 ! promoter_element property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl created_by: kareneilbeck creation_date: 2011-10-10T05:09:45Z [Term] id: SO:0001861 name: sterol_regulatory_element namespace: sequence def: "A 10-bp promoter element bound by sterol regulatory element binding proteins (SREBPs), found in promoters of genes involved in sterol metabolism. Many variants of the sequence ATCACCCCAC function as SREs." [GO:mah, PMID:11111080, PMID:16537923] synonym: "SRE" BROAD [GO:mah] is_a: SO:0001659 ! promoter_element property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl created_by: kareneilbeck creation_date: 2011-10-19T03:02:05Z [Term] id: SO:0001900 name: M26_binding_site namespace: sequence def: "A promoter element that contains a core sequence TGACGT, bound by a protein complex that regulates transcription of genes encoding PKA pathway components." [PMID:15448137] synonym: "m26 site" EXACT [] is_a: SO:0000713 ! DNA_motif property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl created_by: kareneilbeck creation_date: 2012-04-06T12:02:10Z [Term] id: SO:0001905 name: regional_centromere_outer_repeat_transcript namespace: sequence def: "A transcript that is transcribed from the outer repeat region of a regional centromere." [PomBase:mah] synonym: "centromere outer repeat transcript" EXACT [] synonym: "regional centromere outer repeat region transcript" EXACT [] synonym: "regional_centromere_outer_repeat_region_transcript" EXACT [] is_a: SO:0000185 ! primary_transcript intersection_of: SO:0000185 ! primary_transcript intersection_of: derives_from SO:0001799 ! regional_centromere_outer_repeat_region relationship: derives_from SO:0001799 ! regional_centromere_outer_repeat_region property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl created_by: kareneilbeck creation_date: 2012-04-11T04:54:22Z [Term] id: SO:0001914 name: rDNA_replication_fork_barrier namespace: sequence def: "A DNA motif that is found in eukaryotic rDNA repeats, and is a site of replication fork pausing." [PMID:14645529] comment: Requested by Midori - June 2012. synonym: "DNA spacer replication fork barrier" EXACT [] synonym: "rDNA replication fork barrier" EXACT [] synonym: "RFB" EXACT [] synonym: "RTS1 barrier" EXACT [] synonym: "RTS1 element" EXACT [] is_a: SO:0000713 ! DNA_motif property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl created_by: kareneilbeck creation_date: 2012-06-11T02:55:02Z [Term] id: SO:0001927 name: telomeric_transcript namespace: sequence def: "A non-coding transcript derived from the transcript of the telomere." [PMID:22139915] synonym: "telomeric transcript" EXACT [] is_a: SO:0000655 ! ncRNA property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl created_by: kareneilbeck creation_date: 2012-10-31T01:42:15Z [Term] id: SO:0001958 name: lariat_intron namespace: sequence def: "A kind of intron whereby the excision is driven by lariat formation." [SO:ke] comment: Requested by PomBase 3604508. synonym: "lariat intron" EXACT [] is_a: SO:0000188 ! intron property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl created_by: kareneilbeck creation_date: 2013-03-07T10:58:40Z [Term] id: SO:0001984 name: silent_mating_type_cassette_array namespace: sequence def: "A gene cassette array that corresponds to a silenced version of a mating type region." [PomBase:mah] synonym: "silent mating-type cassette" RELATED [] is_a: SO:0005854 ! gene_cassette_array property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl created_by: kareneilbeck creation_date: 2013-07-31T02:40:38Z [Term] id: SO:0001985 name: Okazaki_fragment namespace: sequence def: "Any of the DNA segments produced by discontinuous synthesis of the lagging strand during DNA replication." [ISBN:0805350152] comment: Requested by Midori Harris, 2013. synonym: "Okazaki fragment" EXACT [] is_a: SO:0001411 ! biological_region property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl created_by: kareneilbeck creation_date: 2013-07-31T02:57:55Z [Term] id: SO:0001997 name: subtelomere namespace: sequence def: "A heterochromatic region of the chromosome, adjacent to the telomere (on the centromeric side) that contains repetitive DNA and sometimes genes and it is transcribed." [POMBE:al] is_a: SO:0000628 ! chromosomal_structural_element property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl created_by: kareneilbeck creation_date: 2014-01-05T07:02:01Z [Term] id: SO:0002021 name: mating_type_region_replication_fork_barrier namespace: sequence def: "A DNA motif that is found in eukaryotic rDNA repeats, and is a site of replication fork pausing." [PMID:17614787] comment: Requested by Midori Harris. synonym: "mating type region replication fork barrier" EXACT [] is_a: SO:0000713 ! DNA_motif property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl created_by: kareneilbeck creation_date: 2014-05-30T14:57:26Z [Term] id: SO:0002025 name: cis_acting_homologous_chromosome_pairing_region namespace: sequence def: "A genome region where chromosome pairing occurs preferentially during homologous chromosome pairing during early meiotic prophase of Meiosis I." [PMID:22582262, PMID:23117617, PMID:24173580, PomBase:vw] comment: comment: An example of this is the Sme2 locus in fission yeast S. pombe, where is coincident with an ribonuclear complex termed the "Mei2 dot". This term was Requested by Val Wood, PomBase. synonym: "cis-acting homologous chromosome pairing region" EXACT [] is_a: SO:0000713 ! DNA_motif property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl created_by: kareneilbeck creation_date: 2014-07-14T11:40:34Z [Term] id: SO:0005836 name: regulatory_region namespace: sequence def: "A region of sequence that is involved in the control of a biological process." [SO:ke] subset: SOFA synonym: "regulatory region" EXACT [] xref: http://en.wikipedia.org/wiki/Regulatory_region "wiki" is_a: SO:0000831 ! gene_member_region property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0005853 name: gene_cassette namespace: sequence def: "A gene that can be substituted for a related gene at a different site in the genome." [SGD:se] comment: This would include, for example, the mating type gene cassettes of S. cerevisiae. Gene cassettes usually exist as linear sequences as part of a larger DNA molecule, such as a chromosome or plasmid. synonym: "gene cassette" EXACT [] xref: http://en.wikipedia.org/wiki/Gene_cassette "wiki" is_a: SO:0000704 ! gene property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0005854 name: gene_cassette_array namespace: sequence def: "An array of non-functional genes whose members, when captured by recombination form functional genes." [SO:ma] comment: This would include, for example, the arrays of non-functional VSG genes of Trypanosomes. synonym: "gene cassette array" EXACT [] is_a: SO:0005855 ! gene_group relationship: has_part SO:0005853 ! gene_cassette property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Term] id: SO:0005855 name: gene_group namespace: sequence def: "A collection of related genes." [SO:ma] subset: SOFA synonym: "gene group" EXACT [] is_a: SO:0001411 ! biological_region property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Typedef] id: adjacent_to name: adjacent_to namespace: sequence def: "A geometric operator, specified in Egenhofer 1989. Two features meet if they share a junction on the sequence. X adjacent_to Y iff X and Y share a boundary but do not overlap." [PMID:20226267, SO:ke] subset: SOFA property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Typedef] id: contains name: contains namespace: sequence def: "The inverse of contained_by." [PMID:20226267] comment: Example: pre_miRNA contains miRNA_loop. property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl is_transitive: true created_by: kareneilbeck creation_date: 2010-10-14T01:32:15Z [Typedef] id: decreased_in_magnitude_relative_to name: decreased_in_magnitude_relative_to namespace: quality def: "q1 decreased_in_magnitude_relative_to q2 if and only if magnitude(q1) < magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." [PATOC:CJM] comment: This relation is used to determine the 'directionality' of relative qualities such as 'decreased strength', relative to the parent type, 'strength'. property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl domain: PATO:0000001 ! quality range: PATO:0000001 ! quality is_transitive: true is_a: different_in_magnitude_relative_to ! different_in_magnitude_relative_to [Typedef] id: derives_from name: derives_from namespace: sequence subset: SOFA property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl is_transitive: true [Typedef] id: develops_from name: develops_from xref: RO:0002202 property_value: IAO:0000412 http://purl.obolibrary.org/obo/cl/cl-basic.owl [Typedef] id: different_in_magnitude_relative_to name: different_in_magnitude_relative_to namespace: quality def: "q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." [PATOC:CJM] property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl domain: PATO:0000001 ! quality range: PATO:0000001 ! quality [Typedef] id: directly_associated_with name: directly_associated_with namespace: quality def: "q1 directly_associated_with q2 iff q1 is dependent on q2, and the magnitude of q1 increases if the magnitude of q2 is increased, or the magnitude of q1 decreases if the magnitude of q2 is decreased. The relationship is not necessarily linear." [PATOC:cjm, Wikipedia:Association_(statistics)] comment: Example: 'Lewy bodies increased number related to dystrophic neurite increased number' (from annotation of PMID:8740227 in http://ccdb.ucsd.edu/1.0/NDPO.owl#ndpo_404). Here the increase in the number of lewy bodies is directly_associated_with the increase in the number of dystrophic neurites.\nAssociation is weaker than correlation or proportionality. These relations may be later added to PATO. property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl domain: PATO:0000001 ! quality range: PATO:0000001 ! quality created_by: cjm creation_date: 2009-08-26T02:50:08Z [Typedef] id: during name: during xref: GOREL:0000002 property_value: usage "Identifies a process, cell cycle stage or life stage during which a phenotype is observed or relevant." xsd:string [Typedef] id: ends_during name: ends_during namespace: external xref: RO:0002093 property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Typedef] id: exists_during name: exists_during xref: GOREL:0000032 property_value: usage "Identifies a process, cell cycle stage or life stage during which a phenotype that affects a continuant, such as a cellular component or the level of a substance, is observed or relevant." xsd:string [Typedef] id: happens__during name: happens__during (UNDECLARED) [Typedef] id: happens_during name: happens_during namespace: external xref: GOREL:0000001 xref: RO:0002092 property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl property_value: usage "Identifies a process, cell cycle stage or life stage during which a phenotype that affects an occurrent, i.e. a biological process or molecular function, is observed or relevant." xsd:string is_transitive: true is_a: ends_during ! ends_during [Typedef] id: has_cross_section name: has_cross_section namespace: quality def: "s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2." [PATOC:CJM] comment: Example: a spherical object has the quality of being spherical, and the spherical quality has_cross_section round. property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Typedef] id: has_dividend_quality name: has_dividend_quality namespace: quality property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl range: PATO:0000001 ! quality is_a: has_ratio_quality ! has_ratio_quality [Typedef] id: has_divisor_quality name: has_divisor_quality namespace: quality property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl range: PATO:0000001 ! quality is_a: has_ratio_quality ! has_ratio_quality [Typedef] id: has_origin name: has_origin namespace: sequence property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Typedef] id: has_output name: has_output def: "p has output c if either: p has direct output c or p has output input c. Implies that if p happens, c always ensues." [GOC:curators] xref: RO:0002234 property_value: usage "Def comes from gorel file. Used in FYPO where one phenotype (p) always results in an additional phenotype (c) as a consequence. There may be other ways to get phenotype (c)." xsd:string [Typedef] id: has_part name: has_part namespace: sequence def: "Inverse of part_of." [http://precedings.nature.com/documents/3495/version/1] comment: Example: operon has_part gene. xref: BFO:0000051 property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl property_value: usage "Used in FYPO to link phenotypes that are collections of features to phenotypes representing the features." xsd:string is_transitive: true [Typedef] id: has_quality name: has_quality namespace: sequence comment: The relationship between a feature and an attribute. property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Typedef] id: has_ratio_quality name: has_ratio_quality namespace: quality property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl range: PATO:0000001 ! quality [Typedef] id: increased_in_magnitude_relative_to name: increased_in_magnitude_relative_to namespace: quality def: "q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." [PATOC:CJM] comment: This relation is used to determine the 'directionality' of relative qualities such as 'increased strength', relative to the parent type, 'strength'. property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl domain: PATO:0000001 ! quality range: PATO:0000001 ! quality is_transitive: true is_a: different_in_magnitude_relative_to ! different_in_magnitude_relative_to [Typedef] id: inheres_in name: inheres_in xref: RO:0000052 property_value: usage "Used in FYPO as described in PATO best practices; identifies an entity that displays a quality in an entity-quality logical definition. Used only in logical definitions (aka xps)." xsd:string [Typedef] id: inheres_in_part_of name: inheres in part of xref: RO:0002314 property_value: usage "Used in FYPO as described in MP/HP logical definition best practices for processes, and in an analogous manner for cell/cell part structure; identifies an entity that displays a quality in an entity-quality logical definition. Used only in logical definitions (aka xps)." xsd:string [Typedef] id: inversely_associated_with name: inversely_associated_with namespace: quality def: "q1 inversely_associated_with q2 iff q1 is dependent on q2, and the magnitude of q1 decreases if the magnitude of q2 is increased, or the magnitude of q1 increases if the magnitude of q2 is decreased. The relationship is not necessarily linear." [PATOC:cjm, Wikipedia:Association_(statistics)] comment: Association is weaker than correlation or proportionality. These relations may be later added to PATO. property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl domain: PATO:0000001 ! quality range: PATO:0000001 ! quality created_by: cjm creation_date: 2009-08-26T02:50:24Z [Typedef] id: member_of name: member_of namespace: sequence comment: A subtype of part_of. Inverse is collection_of. Winston, M, Chaffin, R, Herrmann: A taxonomy of part-whole relations. Cognitive Science 1987, 11:417-444. subset: SOFA property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl is_transitive: true is_a: part_of ! part_of [Typedef] id: negatively_regulates name: negatively regulates namespace: external xref: RO:0002212 property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl is_a: regulates ! regulates [Typedef] id: non_functional_homolog_of name: non_functional_homolog_of namespace: sequence def: "A relationship between a pseudogenic feature and its functional ancestor." [SO:ke] subset: SOFA property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl [Typedef] id: occurs_at name: occurs_at xref: GOREL:0000501 property_value: usage "This relation is not constrained with respect to whether the place where an event occurs completely surrounds, or is adjacent to, the location indicated. Example: chromatin silencing at centromere unfolds_around centromere : Repression of transcription of centromeric DNA by the formation of heterochromatin. Used in FYPO to identify a position where a phenotype is observed or relevant, usually a DNA or RNA sequence feature specified by a SO ID." xsd:string [Typedef] id: occurs_in name: occurs in xref: BFO:0000066 property_value: usage "Used in FYPO to identify a location, usually a cellular component or cell type, within which a phenotype is observed or relevant." xsd:string [Typedef] id: output_of name: output_of synonym: "formation results from" EXACT [PomBase:mah] xref: RO:0002353 property_value: usage "Inverse of has_output. Relation between a structure and a process that forms it, or between one process and a preceding process; A output_of B used where B has_output A isn't always true. Implies that process B is the only way to get output. Used in FYPO where one phenotype (c) always results when another phenotype (p) is present. Phenotype (p) may have other consequences in addition to phenotype (c)." xsd:string [Typedef] id: overlaps name: overlaps namespace: sequence def: "X overlaps Y iff there exists some Z such that Z contained_by X and Z contained_by Y." [PMID:20226267] comment: Example: coding_exon overlaps CDS. property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl created_by: kareneilbeck creation_date: 2010-10-14T01:33:15Z [Typedef] id: part_of name: part_of namespace: sequence def: "X part_of Y if X is a subregion of Y." [http://precedings.nature.com/documents/3495/version/1] comment: Example: amino_acid part_of polypeptide. subset: SOFA xref: BFO:0000050 property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl property_value: usage "Used in FYPO to identify phenotypes that are always observed in the context of another, usually larger-scale, phenotype." xsd:string is_transitive: true [Typedef] id: positively_regulates name: positively regulates namespace: external xref: RO:0002213 property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl is_a: regulates ! regulates [Typedef] id: preceded_by name: preceded_by xref: BFO:0000062 property_value: usage "Used in FYPO when a phenotype is observed after another event, usually a GO biological process, has ended, and where there isn't a suitable process to use with a during relation." xsd:string [Typedef] id: precedes name: precedes xref: BFO:0000063 property_value: usage "Used in FYPO when a phenotype is observed before another event, usually a GO biological process, begins, and where there isn't a suitable process to use with a during relation." xsd:string [Typedef] id: qualifier name: qualifier property_value: usage "Used in FYPO as described in PATO best practices; placeholder relation to indicate normality/abnormality." xsd:string [Typedef] id: reciprocal_of name: reciprocal_of namespace: quality def: "q1 reciprocal_of q2 if and only if : q1 and q2 are relational qualities and a phenotype e q1 e2 mutually implies a phenotype e2 q2 e." [PATOC:CJM] comment: There are frequently two ways to state the same thing: we can say 'spermatocyte lacks asters' or 'asters absent from spermatocyte'. In this case the quality is 'lacking all parts of type' - it is a (relational) quality of the spermatocyte, and it is with respect to instances of 'aster'. One of the popular requirements of PATO is that it continue to support 'absent', so we need to relate statements which use this quality to the 'lacking all parts of type' quality. property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl [Typedef] id: regulates name: regulates namespace: external xref: RO:0002211 property_value: IAO:0000412 http://purl.obolibrary.org/obo/go.owl [Typedef] id: similar_in_magnitude_relative_to name: similar_in_magnitude_relative_to namespace: quality def: "q1 similar_in_magnitude_relative_to q2 if and only if magnitude(q1) =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale." [PATOC:CJM] property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl domain: PATO:0000001 ! quality range: PATO:0000001 ! quality [Typedef] id: towards name: towards namespace: quality comment: Relation binding a relational quality or disposition to the relevant type of entity. xref: RO:0002503 property_value: IAO:0000412 http://purl.obolibrary.org/obo/pato.owl property_value: usage "Relation binding a relational quality or disposition to the relevant type of entity. Used in FYPO as described in PATO best practices; identifies abolished GO processes; identifies substances affected by phenotypes." xsd:string [Typedef] id: transcribed_from name: transcribed_from namespace: sequence def: "X is transcribed_from Y if X is synthesized from template Y." [http://precedings.nature.com/documents/3495/version/1] comment: Example: primary_transcript transcribed_from gene. property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl created_by: kareneilbeck creation_date: 2009-08-19T12:05:39Z [Typedef] id: transcribed_to name: transcribed_to namespace: sequence def: "Inverse of transcribed_from." [http://precedings.nature.com/documents/3495/version/1] comment: Example: gene transcribed_to primary_transcript. property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl created_by: kareneilbeck creation_date: 2009-08-19T12:08:24Z [Typedef] id: variant_of name: variant_of namespace: sequence def: "A' is a variant (mutation) of A = definition every instance of A' is either an immediate mutation of some instance of A, or there is a chain of immediate mutation processes linking A' to some instance of A." [SO:immuno_workshop] comment: Added to SO during the immunology workshop, June 2007. This relationship was approved by Barry Smith. property_value: IAO:0000412 http://purl.obolibrary.org/obo/so-xp.obo.owl