<?xml version="1.0"?>
<diffReport>
<diffSummary>
<numberChangedClasses>
62
</numberChangedClasses>
<numberNewClasses>
49
</numberNewClasses>
<numberDeletedClasses>
2
</numberDeletedClasses>
</diffSummary>
<changedClasses>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005219</classIRI>
<classLabel>ryanodine-sensitive calcium-release channel activity</classLabel>
<deletedAxiom>&apos;ryanodine-sensitive calcium-release channel activity&apos; SubClassOf &apos;intracellular ligand-gated calcium channel activity&apos;</deletedAxiom>
<newAxiom>&apos;ryanodine-sensitive calcium-release channel activity&apos; SubClassOf &apos;calcium-release channel activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005218</classIRI>
<classLabel>intracellular ligand-gated calcium channel activity</classLabel>
<deletedAxiom>&apos;intracellular ligand-gated calcium channel activity&apos; SubClassOf &apos;calcium-release channel activity&apos;</deletedAxiom>
<deletedAxiom>&apos;intracellular ligand-gated calcium channel activity&apos; SubClassOf &apos;receptor signaling protein activity&apos;</deletedAxiom>
<deletedAxiom>&apos;intracellular ligand-gated calcium channel activity&apos; SubClassOf &apos;intracellular ligand-gated ion channel activity&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005220</classIRI>
<classLabel>inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity</classLabel>
<deletedAxiom>&apos;inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity&apos; SubClassOf &apos;intracellular ligand-gated calcium channel activity&apos;</deletedAxiom>
<newAxiom>&apos;inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity&apos; SubClassOf &apos;calcium-release channel activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0034354</classIRI>
<classLabel>&apos;de novo&apos; NAD biosynthetic process from tryptophan</classLabel>
<newAxiom>&apos;&apos;de novo&apos; NAD biosynthetic process from tryptophan&apos; SubClassOf &apos;tryptophan metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0048018</classIRI>
<classLabel>receptor agonist activity</classLabel>
<newAxiom>&apos;receptor agonist activity&apos; SubClassOf &apos;signal transducer activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005068</classIRI>
<classLabel>transmembrane receptor protein tyrosine kinase adaptor activity</classLabel>
<newAxiom>&apos;transmembrane receptor protein tyrosine kinase adaptor activity&apos; SubClassOf &apos;signal transducer activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071205</classIRI>
<classLabel>protein localization to juxtaparanode region of axon</classLabel>
<newAxiom>&apos;protein localization to juxtaparanode region of axon&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099612</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0036339</classIRI>
<classLabel>lymphocyte adhesion to endothelial cell of high endothelial venule</classLabel>
<deletedAxiom>&apos;lymphocyte adhesion to endothelial cell of high endothelial venule&apos; SubClassOf &apos;leukocyte cell-cell adhesion&apos;</deletedAxiom>
<newAxiom>&apos;lymphocyte adhesion to endothelial cell of high endothelial venule&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0061756</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0048763</classIRI>
<classLabel>calcium-induced calcium release activity</classLabel>
<deletedAxiom>&apos;calcium-induced calcium release activity&apos; SubClassOf &apos;intracellular ligand-gated calcium channel activity&apos;</deletedAxiom>
<newAxiom>&apos;calcium-induced calcium release activity&apos; SubClassOf &apos;calcium-release channel activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019932</classIRI>
<classLabel>second-messenger-mediated signaling</classLabel>
<deletedAxiom>&apos;second-messenger-mediated signaling&apos; SubClassOf &apos;intracellular signal transduction&apos;</deletedAxiom>
<newAxiom>&apos;second-messenger-mediated signaling&apos; SubClassOf &apos;signal transduction&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071411</classIRI>
<classLabel>cellular response to fluoxetine</classLabel>
<newAxiom>&apos;cellular response to fluoxetine&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010554</classIRI>
<classLabel>neurotransmitter secretory pathway</classLabel>
<newAxiom>&apos;neurotransmitter secretory pathway&apos; SubClassOf &apos;presynaptic process involved in synaptic transmission&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0038078</classIRI>
<classLabel>MAP kinase phosphatase activity involved in regulation of innate immune response</classLabel>
<newAxiom>&apos;MAP kinase phosphatase activity involved in regulation of innate immune response&apos; SubClassOf &apos;signal transducer activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031585</classIRI>
<classLabel>regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity</classLabel>
<newAxiom>&apos;regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity&apos; SubClassOf &apos;regulation of calcium-mediated signaling&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031586</classIRI>
<classLabel>negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity</classLabel>
<newAxiom>&apos;negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity&apos; SubClassOf &apos;negative regulation of calcium-mediated signaling&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031587</classIRI>
<classLabel>positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity</classLabel>
<newAxiom>&apos;positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity&apos; SubClassOf &apos;positive regulation of calcium-mediated signaling&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0098915</classIRI>
<classLabel>membrane repolarization during ventricular cardiac muscle cell action potential</classLabel>
<newAxiom>&apos;membrane repolarization during ventricular cardiac muscle cell action potential&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099625</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0098914</classIRI>
<classLabel>membrane repolarization during atrial cardiac muscle cell action potential</classLabel>
<newAxiom>&apos;membrane repolarization during atrial cardiac muscle cell action potential&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099624</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904600</classIRI>
<classLabel>actin fusion focus assembly</classLabel>
<newAxiom>&apos;actin fusion focus assembly&apos; SubClassOf &apos;actin cytoskeleton organization&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904601</classIRI>
<classLabel>protein localization to actin fusion focus</classLabel>
<newAxiom>&apos;protein localization to actin fusion focus&apos; SubClassOf &apos;protein localization to actin cytoskeleton&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0014076</classIRI>
<classLabel>response to fluoxetine</classLabel>
<newAxiom>&apos;response to fluoxetine&apos; SubClassOf &apos;response to antidepressant&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1990890</classIRI>
<classLabel>netrin receptor binding</classLabel>
<newAxiom>&apos;netrin receptor binding&apos; SubClassOf &apos;signal transducer activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0008086</classIRI>
<classLabel>light-activated voltage-gated calcium channel activity</classLabel>
<newAxiom>&apos;light-activated voltage-gated calcium channel activity&apos; SubClassOf &apos;signal transducer activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1990819</classIRI>
<classLabel>actin fusion focus</classLabel>
<newAxiom>&apos;actin fusion focus&apos; SubClassOf &apos;cytoskeletal part&apos;</newAxiom>
<newAxiom>&apos;actin fusion focus&apos; SubClassOf &apos;part of&apos; some &apos;actin cytoskeleton&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0022849</classIRI>
<classLabel>glutamate-gated calcium ion channel activity</classLabel>
<deletedAxiom>&apos;glutamate-gated calcium ion channel activity&apos; SubClassOf &apos;transmitter-gated ion channel activity&apos;</deletedAxiom>
<newAxiom>&apos;glutamate-gated calcium ion channel activity&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099604</newAxiom>
<newAxiom>&apos;glutamate-gated calcium ion channel activity&apos; SubClassOf &apos;ionotropic glutamate receptor activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0022835</classIRI>
<classLabel>transmitter-gated channel activity</classLabel>
<newAxiom>&apos;transmitter-gated channel activity&apos; SubClassOf &apos;transmembrane signaling receptor activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0022834</classIRI>
<classLabel>ligand-gated channel activity</classLabel>
<deletedAxiom>&apos;ligand-gated channel activity&apos; SubClassOf &apos;receptor activity&apos;</deletedAxiom>
<newAxiom>&apos;ligand-gated channel activity&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099600</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031958</classIRI>
<classLabel>corticosteroid receptor signaling pathway</classLabel>
<newAxiom>&apos;corticosteroid receptor signaling pathway&apos; SubClassOf &apos;steroid hormone mediated signaling pathway&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0008384</classIRI>
<classLabel>IkappaB kinase activity</classLabel>
<newAxiom>&apos;IkappaB kinase activity&apos; SubClassOf &apos;receptor signaling protein activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006111</classIRI>
<classLabel>regulation of gluconeogenesis</classLabel>
<deletedAxiom>&apos;regulation of gluconeogenesis&apos; SubClassOf &apos;regulation of cellular biosynthetic process&apos;</deletedAxiom>
<deletedAxiom>&apos;regulation of gluconeogenesis&apos; SubClassOf &apos;regulation of cellular ketone metabolic process&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0050901</classIRI>
<classLabel>leukocyte tethering or rolling</classLabel>
<deletedAxiom>&apos;leukocyte tethering or rolling&apos; SubClassOf &apos;leukocyte cell-cell adhesion&apos;</deletedAxiom>
<newAxiom>&apos;leukocyte tethering or rolling&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0061756</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0050903</classIRI>
<classLabel>leukocyte activation-dependent arrest</classLabel>
<deletedAxiom>&apos;leukocyte activation-dependent arrest&apos; SubClassOf &apos;leukocyte cell-cell adhesion&apos;</deletedAxiom>
<newAxiom>&apos;leukocyte activation-dependent arrest&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0061756</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0035584</classIRI>
<classLabel>calcium-mediated signaling using intracellular calcium source</classLabel>
<newAxiom>&apos;calcium-mediated signaling using intracellular calcium source&apos; EquivalentTo &apos;calcium-mediated signaling&apos; and (&apos;starts with&apos; some &apos;release of sequestered calcium ion into cytosol&apos;)</newAxiom>
<newAxiom>&apos;calcium-mediated signaling using intracellular calcium source&apos; SubClassOf &apos;starts with&apos; some &apos;release of sequestered calcium ion into cytosol&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0035585</classIRI>
<classLabel>calcium-mediated signaling using extracellular calcium source</classLabel>
<newAxiom>&apos;calcium-mediated signaling using extracellular calcium source&apos; EquivalentTo &apos;calcium-mediated signaling&apos; and (&apos;starts with&apos; some &apos;calcium ion import across plasma membrane&apos;)</newAxiom>
<newAxiom>&apos;calcium-mediated signaling using extracellular calcium source&apos; SubClassOf &apos;starts with&apos; some &apos;calcium ion import across plasma membrane&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0002175</classIRI>
<classLabel>protein localization to paranode region of axon</classLabel>
<newAxiom>&apos;protein localization to paranode region of axon&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099612</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904031</classIRI>
<classLabel>positive regulation of cyclin-dependent protein kinase activity</classLabel>
<deletedAxiom>&apos;positive regulation of cyclin-dependent protein kinase activity&apos; SubClassOf &apos;regulation of cytokinesis&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0004871</classIRI>
<classLabel>signal transducer activity</classLabel>
<deletedAxiom>&apos;signal transducer activity&apos; SubClassOf &apos;molecular transducer activity&apos;</deletedAxiom>
<newAxiom>&apos;signal transducer activity&apos; SubClassOf &apos;molecular_function&apos;</newAxiom>
<newAxiom>&apos;signal transducer activity&apos; EquivalentTo &apos;molecular_function&apos; and (&apos;part of&apos; some &apos;signal transduction&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0004879</classIRI>
<classLabel>RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding</classLabel>
<newAxiom>&apos;RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding&apos; SubClassOf &apos;signal transducer activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0004888</classIRI>
<classLabel>transmembrane signaling receptor activity</classLabel>
<newAxiom>&apos;transmembrane signaling receptor activity&apos; EquivalentTo http://purl.obolibrary.org/obo/GO_0099600 and (&apos;part of&apos; some &apos;signal transduction&apos;)</newAxiom>
<newAxiom>&apos;transmembrane signaling receptor activity&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099600</newAxiom>
<newAxiom>&apos;transmembrane signaling receptor activity&apos; SubClassOf &apos;part of&apos; some &apos;signal transduction&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0004708</classIRI>
<classLabel>MAP kinase kinase activity</classLabel>
<newAxiom>&apos;MAP kinase kinase activity&apos; SubClassOf &apos;receptor signaling protein activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072346</classIRI>
<classLabel>cADPR-sensitive calcium-release channel activity</classLabel>
<deletedAxiom>&apos;cADPR-sensitive calcium-release channel activity&apos; SubClassOf &apos;intracellular ligand-gated calcium channel activity&apos;</deletedAxiom>
<newAxiom>&apos;cADPR-sensitive calcium-release channel activity&apos; SubClassOf &apos;calcium-release channel activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072345</classIRI>
<classLabel>NAADP-sensitive calcium-release channel activity</classLabel>
<deletedAxiom>&apos;NAADP-sensitive calcium-release channel activity&apos; SubClassOf &apos;intracellular ligand-gated calcium channel activity&apos;</deletedAxiom>
<newAxiom>&apos;NAADP-sensitive calcium-release channel activity&apos; SubClassOf &apos;calcium-release channel activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0004971</classIRI>
<classLabel>AMPA glutamate receptor activity</classLabel>
<deletedAxiom>&apos;AMPA glutamate receptor activity&apos; SubClassOf &apos;has input&apos; some http://purl.obolibrary.org/obo/CHEBI_28812</deletedAxiom>
<deletedAxiom>&apos;AMPA glutamate receptor activity&apos; EquivalentTo &apos;receptor activity&apos; and (&apos;has input&apos; some http://purl.obolibrary.org/obo/CHEBI_28812)</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0035376</classIRI>
<classLabel>sterol import</classLabel>
<deletedAxiom>&apos;sterol import&apos; SubClassOf &apos;sterol transmembrane transport&apos;</deletedAxiom>
<newAxiom>&apos;sterol import&apos; SubClassOf &apos;sterol transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0060316</classIRI>
<classLabel>positive regulation of ryanodine-sensitive calcium-release channel activity</classLabel>
<newAxiom>&apos;positive regulation of ryanodine-sensitive calcium-release channel activity&apos; SubClassOf &apos;positive regulation of calcium-mediated signaling&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0060315</classIRI>
<classLabel>negative regulation of ryanodine-sensitive calcium-release channel activity</classLabel>
<newAxiom>&apos;negative regulation of ryanodine-sensitive calcium-release channel activity&apos; SubClassOf &apos;negative regulation of calcium-mediated signaling&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0060314</classIRI>
<classLabel>regulation of ryanodine-sensitive calcium-release channel activity</classLabel>
<newAxiom>&apos;regulation of ryanodine-sensitive calcium-release channel activity&apos; SubClassOf &apos;regulation of calcium-mediated signaling&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0060307</classIRI>
<classLabel>regulation of ventricular cardiac muscle cell membrane repolarization</classLabel>
<deletedAxiom>&apos;regulation of ventricular cardiac muscle cell membrane repolarization&apos; SubClassOf &apos;regulation of membrane repolarization&apos;</deletedAxiom>
<newAxiom>&apos;regulation of ventricular cardiac muscle cell membrane repolarization&apos; EquivalentTo &apos;biological regulation&apos; and (&apos;regulates&apos; some http://purl.obolibrary.org/obo/GO_0099625)</newAxiom>
<newAxiom>&apos;regulation of ventricular cardiac muscle cell membrane repolarization&apos; SubClassOf &apos;regulates&apos; some http://purl.obolibrary.org/obo/GO_0099625</newAxiom>
<newAxiom>&apos;regulation of ventricular cardiac muscle cell membrane repolarization&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099623</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015276</classIRI>
<classLabel>ligand-gated ion channel activity</classLabel>
<deletedAxiom>&apos;ligand-gated ion channel activity&apos; SubClassOf &apos;transmembrane signaling receptor activity&apos;</deletedAxiom>
<newAxiom>&apos;ligand-gated ion channel activity&apos; SubClassOf &apos;transports or maintains localization of&apos; some http://purl.obolibrary.org/obo/CHEBI_36914</newAxiom>
<newAxiom>&apos;ligand-gated ion channel activity&apos; EquivalentTo &apos;ligand-gated channel activity&apos; and (&apos;transports or maintains localization of&apos; some http://purl.obolibrary.org/obo/CHEBI_36914)</newAxiom>
<newAxiom>&apos;ligand-gated ion channel activity&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099600</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015278</classIRI>
<classLabel>calcium-release channel activity</classLabel>
<deletedAxiom>&apos;calcium-release channel activity&apos; EquivalentTo &apos;channel activity&apos; and (&apos;part of&apos; some &apos;release of sequestered calcium ion into cytosol&apos;) and (&apos;transports or maintains localization of&apos; some http://purl.obolibrary.org/obo/CHEBI_39123)</deletedAxiom>
<deletedAxiom>&apos;calcium-release channel activity&apos; SubClassOf &apos;calcium channel activity&apos;</deletedAxiom>
<newAxiom>&apos;calcium-release channel activity&apos; SubClassOf &apos;intracellular ligand-gated ion channel activity&apos;</newAxiom>
<newAxiom>&apos;calcium-release channel activity&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099604</newAxiom>
<newAxiom>&apos;calcium-release channel activity&apos; EquivalentTo &apos;ligand-gated channel activity&apos; and (&apos;part of&apos; some &apos;release of sequestered calcium ion into cytosol&apos;) and (&apos;transports or maintains localization of&apos; some http://purl.obolibrary.org/obo/CHEBI_39123)</newAxiom>
<newAxiom>&apos;calcium-release channel activity&apos; SubClassOf &apos;receptor signaling protein activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0086013</classIRI>
<classLabel>membrane repolarization during cardiac muscle cell action potential</classLabel>
<newAxiom>&apos;membrane repolarization during cardiac muscle cell action potential&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099622</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0097199</classIRI>
<classLabel>cysteine-type endopeptidase activity involved in apoptotic signaling pathway</classLabel>
<newAxiom>&apos;cysteine-type endopeptidase activity involved in apoptotic signaling pathway&apos; SubClassOf &apos;signal transducer activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0030297</classIRI>
<classLabel>transmembrane receptor protein tyrosine kinase activator activity</classLabel>
<newAxiom>&apos;transmembrane receptor protein tyrosine kinase activator activity&apos; SubClassOf &apos;signal transducer activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0044536</classIRI>
<classLabel>envenomation resulting in depletion of circulating fibrinogen in other organism</classLabel>
<deletedAxiom>&apos;envenomation resulting in depletion of circulating fibrinogen in other organism&apos; SubClassOf &apos;regulation of circulating fibrinogen levels&apos;</deletedAxiom>
<newAxiom>&apos;envenomation resulting in depletion of circulating fibrinogen in other organism&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0061754</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903238</classIRI>
<classLabel>positive regulation of leukocyte tethering or rolling</classLabel>
<deletedAxiom>&apos;positive regulation of leukocyte tethering or rolling&apos; SubClassOf &apos;positive regulation of leukocyte cell-cell adhesion&apos;</deletedAxiom>
<newAxiom>&apos;positive regulation of leukocyte tethering or rolling&apos; SubClassOf http://purl.obolibrary.org/obo/GO_1904996</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903237</classIRI>
<classLabel>negative regulation of leukocyte tethering or rolling</classLabel>
<deletedAxiom>&apos;negative regulation of leukocyte tethering or rolling&apos; SubClassOf &apos;negative regulation of leukocyte cell-cell adhesion&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of leukocyte tethering or rolling&apos; SubClassOf http://purl.obolibrary.org/obo/GO_1904995</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903236</classIRI>
<classLabel>regulation of leukocyte tethering or rolling</classLabel>
<deletedAxiom>&apos;regulation of leukocyte tethering or rolling&apos; SubClassOf &apos;regulation of leukocyte cell-cell adhesion&apos;</deletedAxiom>
<newAxiom>&apos;regulation of leukocyte tethering or rolling&apos; SubClassOf http://purl.obolibrary.org/obo/GO_1904994</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0030518</classIRI>
<classLabel>intracellular steroid hormone receptor signaling pathway</classLabel>
<newAxiom>&apos;intracellular steroid hormone receptor signaling pathway&apos; SubClassOf &apos;steroid hormone mediated signaling pathway&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903952</classIRI>
<classLabel>regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization</classLabel>
<newAxiom>&apos;regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099623</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0060372</classIRI>
<classLabel>regulation of atrial cardiac muscle cell membrane repolarization</classLabel>
<deletedAxiom>&apos;regulation of atrial cardiac muscle cell membrane repolarization&apos; SubClassOf &apos;regulation of membrane repolarization&apos;</deletedAxiom>
<newAxiom>&apos;regulation of atrial cardiac muscle cell membrane repolarization&apos; EquivalentTo &apos;biological regulation&apos; and (&apos;regulates&apos; some http://purl.obolibrary.org/obo/GO_0099624)</newAxiom>
<newAxiom>&apos;regulation of atrial cardiac muscle cell membrane repolarization&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099623</newAxiom>
<newAxiom>&apos;regulation of atrial cardiac muscle cell membrane repolarization&apos; SubClassOf &apos;regulates&apos; some http://purl.obolibrary.org/obo/GO_0099624</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0007269</classIRI>
<classLabel>neurotransmitter secretion</classLabel>
<newAxiom>&apos;neurotransmitter secretion&apos; SubClassOf &apos;occurs in&apos; some &apos;presynapse&apos;</newAxiom>
<newAxiom>&apos;neurotransmitter secretion&apos; SubClassOf &apos;presynaptic process involved in synaptic transmission&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903760</classIRI>
<classLabel>regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization</classLabel>
<newAxiom>&apos;regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099623</newAxiom>
</changedClass>
</changedClasses>
<newClasses>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28747</classIRI>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0036520</classIRI>
<classLabel>astrocyte-dopaminergic neuron signaling</classLabel>
<newAxiom>'astrocyte-dopaminergic neuron signaling' SubClassOf 'cell-cell signaling'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905002</classIRI>
<classLabel>positive regulation of membrane repolarization during atrial cardiac muscle cell action potential</classLabel>
<newAxiom>'positive regulation of membrane repolarization during atrial cardiac muscle cell action potential' SubClassOf 'positively regulates' some 'membrane repolarization during atrial cardiac muscle cell action potential'</newAxiom>
<newAxiom>'positive regulation of membrane repolarization during atrial cardiac muscle cell action potential' SubClassOf 'regulation of membrane repolarization during atrial cardiac muscle cell action potential'</newAxiom>
<newAxiom>'positive regulation of membrane repolarization during atrial cardiac muscle cell action potential' SubClassOf 'positive regulation of atrial cardiac muscle cell action potential'</newAxiom>
<newAxiom>'positive regulation of membrane repolarization during atrial cardiac muscle cell action potential' SubClassOf 'positive regulation of ion transmembrane transport'</newAxiom>
<newAxiom>'positive regulation of membrane repolarization during atrial cardiac muscle cell action potential' EquivalentTo 'biological regulation' and ('positively regulates' some 'membrane repolarization during atrial cardiac muscle cell action potential')</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905001</classIRI>
<classLabel>negative regulation of membrane repolarization during atrial cardiac muscle cell action potential</classLabel>
<newAxiom>'negative regulation of membrane repolarization during atrial cardiac muscle cell action potential' SubClassOf 'negative regulation of ion transmembrane transport'</newAxiom>
<newAxiom>'negative regulation of membrane repolarization during atrial cardiac muscle cell action potential' SubClassOf 'negative regulation of atrial cardiac muscle cell action potential'</newAxiom>
<newAxiom>'negative regulation of membrane repolarization during atrial cardiac muscle cell action potential' EquivalentTo 'biological regulation' and ('negatively regulates' some 'membrane repolarization during atrial cardiac muscle cell action potential')</newAxiom>
<newAxiom>'negative regulation of membrane repolarization during atrial cardiac muscle cell action potential' SubClassOf 'regulation of membrane repolarization during atrial cardiac muscle cell action potential'</newAxiom>
<newAxiom>'negative regulation of membrane repolarization during atrial cardiac muscle cell action potential' SubClassOf 'negatively regulates' some 'membrane repolarization during atrial cardiac muscle cell action potential'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905000</classIRI>
<classLabel>regulation of membrane repolarization during atrial cardiac muscle cell action potential</classLabel>
<newAxiom>'regulation of membrane repolarization during atrial cardiac muscle cell action potential' SubClassOf 'regulation of membrane repolarization during action potential'</newAxiom>
<newAxiom>'regulation of membrane repolarization during atrial cardiac muscle cell action potential' SubClassOf 'regulates' some 'membrane repolarization during atrial cardiac muscle cell action potential'</newAxiom>
<newAxiom>'regulation of membrane repolarization during atrial cardiac muscle cell action potential' EquivalentTo 'biological regulation' and ('regulates' some 'membrane repolarization during atrial cardiac muscle cell action potential')</newAxiom>
<newAxiom>'regulation of membrane repolarization during atrial cardiac muscle cell action potential' SubClassOf 'regulation of atrial cardiac muscle cell action potential'</newAxiom>
<newAxiom>'regulation of membrane repolarization during atrial cardiac muscle cell action potential' SubClassOf 'regulation of atrial cardiac muscle cell membrane repolarization'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905005</classIRI>
<classLabel>regulation of epithelial to mesenchymal transition involved in endocardial cushion formation</classLabel>
<newAxiom>'regulation of epithelial to mesenchymal transition involved in endocardial cushion formation' SubClassOf 'regulation of epithelial to mesenchymal transition'</newAxiom>
<newAxiom>'regulation of epithelial to mesenchymal transition involved in endocardial cushion formation' SubClassOf 'regulation of heart morphogenesis'</newAxiom>
<newAxiom>'regulation of epithelial to mesenchymal transition involved in endocardial cushion formation' SubClassOf 'regulates' some 'epithelial to mesenchymal transition involved in endocardial cushion formation'</newAxiom>
<newAxiom>'regulation of epithelial to mesenchymal transition involved in endocardial cushion formation' EquivalentTo 'biological regulation' and ('regulates' some 'epithelial to mesenchymal transition involved in endocardial cushion formation')</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905006</classIRI>
<classLabel>negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation</classLabel>
<newAxiom>'negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation' SubClassOf 'regulation of epithelial to mesenchymal transition involved in endocardial cushion formation'</newAxiom>
<newAxiom>'negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation' SubClassOf 'negatively regulates' some 'epithelial to mesenchymal transition involved in endocardial cushion formation'</newAxiom>
<newAxiom>'negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation' EquivalentTo 'biological regulation' and ('negatively regulates' some 'epithelial to mesenchymal transition involved in endocardial cushion formation')</newAxiom>
<newAxiom>'negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation' SubClassOf 'negative regulation of epithelial to mesenchymal transition'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905003</classIRI>
<classLabel>picolinic acid metabolic process</classLabel>
<newAxiom>'picolinic acid metabolic process' SubClassOf 'pyridine-containing compound metabolic process'</newAxiom>
<newAxiom>'picolinic acid metabolic process' EquivalentTo 'metabolic process' and ('has participant' some http://purl.obolibrary.org/obo/CHEBI_28747)</newAxiom>
<newAxiom>'picolinic acid metabolic process' SubClassOf 'cellular aromatic compound metabolic process'</newAxiom>
<newAxiom>'picolinic acid metabolic process' SubClassOf 'has participant' some http://purl.obolibrary.org/obo/CHEBI_28747</newAxiom>
<newAxiom>'picolinic acid metabolic process' SubClassOf 'monocarboxylic acid metabolic process'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905004</classIRI>
<classLabel>picolinic acid biosynthetic process</classLabel>
<newAxiom>'picolinic acid biosynthetic process' SubClassOf 'aromatic compound biosynthetic process'</newAxiom>
<newAxiom>'picolinic acid biosynthetic process' SubClassOf 'pyridine-containing compound biosynthetic process'</newAxiom>
<newAxiom>'picolinic acid biosynthetic process' SubClassOf 'has output' some http://purl.obolibrary.org/obo/CHEBI_28747</newAxiom>
<newAxiom>'picolinic acid biosynthetic process' EquivalentTo 'biosynthetic process' and ('has output' some http://purl.obolibrary.org/obo/CHEBI_28747)</newAxiom>
<newAxiom>'picolinic acid biosynthetic process' SubClassOf 'monocarboxylic acid biosynthetic process'</newAxiom>
<newAxiom>'picolinic acid biosynthetic process' SubClassOf 'picolinic acid metabolic process'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905007</classIRI>
<classLabel>positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation</classLabel>
<newAxiom>'positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation' SubClassOf 'positively regulates' some 'epithelial to mesenchymal transition involved in endocardial cushion formation'</newAxiom>
<newAxiom>'positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation' SubClassOf 'positive regulation of epithelial to mesenchymal transition'</newAxiom>
<newAxiom>'positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation' EquivalentTo 'biological regulation' and ('positively regulates' some 'epithelial to mesenchymal transition involved in endocardial cushion formation')</newAxiom>
<newAxiom>'positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation' SubClassOf 'regulation of epithelial to mesenchymal transition involved in endocardial cushion formation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904998</classIRI>
<classLabel>negative regulation of leukocyte adhesion to arterial endothelial cell</classLabel>
<newAxiom>'negative regulation of leukocyte adhesion to arterial endothelial cell' SubClassOf 'negatively regulates' some 'leukocyte adhesion to arterial endothelial cell'</newAxiom>
<newAxiom>'negative regulation of leukocyte adhesion to arterial endothelial cell' EquivalentTo 'biological regulation' and ('negatively regulates' some 'leukocyte adhesion to arterial endothelial cell')</newAxiom>
<newAxiom>'negative regulation of leukocyte adhesion to arterial endothelial cell' SubClassOf 'regulation of leukocyte adhesion to arterial endothelial cell'</newAxiom>
<newAxiom>'negative regulation of leukocyte adhesion to arterial endothelial cell' SubClassOf 'negative regulation of leukocyte cell-cell adhesion'</newAxiom>
<newAxiom>'negative regulation of leukocyte adhesion to arterial endothelial cell' SubClassOf 'negative regulation of leukocyte adhesion to vascular endothelial cell'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904999</classIRI>
<classLabel>positive regulation of leukocyte adhesion to arterial endothelial cell</classLabel>
<newAxiom>'positive regulation of leukocyte adhesion to arterial endothelial cell' SubClassOf 'positively regulates' some 'leukocyte adhesion to arterial endothelial cell'</newAxiom>
<newAxiom>'positive regulation of leukocyte adhesion to arterial endothelial cell' EquivalentTo 'biological regulation' and ('positively regulates' some 'leukocyte adhesion to arterial endothelial cell')</newAxiom>
<newAxiom>'positive regulation of leukocyte adhesion to arterial endothelial cell' SubClassOf 'regulation of leukocyte adhesion to arterial endothelial cell'</newAxiom>
<newAxiom>'positive regulation of leukocyte adhesion to arterial endothelial cell' SubClassOf 'positive regulation of leukocyte cell-cell adhesion'</newAxiom>
<newAxiom>'positive regulation of leukocyte adhesion to arterial endothelial cell' SubClassOf 'positive regulation of leukocyte adhesion to vascular endothelial cell'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904996</classIRI>
<classLabel>positive regulation of leukocyte adhesion to vascular endothelial cell</classLabel>
<newAxiom>'positive regulation of leukocyte adhesion to vascular endothelial cell' EquivalentTo 'biological regulation' and ('positively regulates' some 'leukocyte adhesion to vascular endothelial cell')</newAxiom>
<newAxiom>'positive regulation of leukocyte adhesion to vascular endothelial cell' SubClassOf 'regulation of leukocyte adhesion to vascular endothelial cell'</newAxiom>
<newAxiom>'positive regulation of leukocyte adhesion to vascular endothelial cell' SubClassOf 'positive regulation of leukocyte cell-cell adhesion'</newAxiom>
<newAxiom>'positive regulation of leukocyte adhesion to vascular endothelial cell' SubClassOf 'positively regulates' some 'leukocyte adhesion to vascular endothelial cell'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904997</classIRI>
<classLabel>regulation of leukocyte adhesion to arterial endothelial cell</classLabel>
<newAxiom>'regulation of leukocyte adhesion to arterial endothelial cell' SubClassOf 'regulates' some 'leukocyte adhesion to arterial endothelial cell'</newAxiom>
<newAxiom>'regulation of leukocyte adhesion to arterial endothelial cell' SubClassOf 'regulation of leukocyte adhesion to vascular endothelial cell'</newAxiom>
<newAxiom>'regulation of leukocyte adhesion to arterial endothelial cell' SubClassOf 'regulation of leukocyte cell-cell adhesion'</newAxiom>
<newAxiom>'regulation of leukocyte adhesion to arterial endothelial cell' EquivalentTo 'biological regulation' and ('regulates' some 'leukocyte adhesion to arterial endothelial cell')</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904994</classIRI>
<classLabel>regulation of leukocyte adhesion to vascular endothelial cell</classLabel>
<newAxiom>'regulation of leukocyte adhesion to vascular endothelial cell' SubClassOf 'regulation of leukocyte cell-cell adhesion'</newAxiom>
<newAxiom>'regulation of leukocyte adhesion to vascular endothelial cell' SubClassOf 'regulates' some 'leukocyte adhesion to vascular endothelial cell'</newAxiom>
<newAxiom>'regulation of leukocyte adhesion to vascular endothelial cell' EquivalentTo 'biological regulation' and ('regulates' some 'leukocyte adhesion to vascular endothelial cell')</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904995</classIRI>
<classLabel>negative regulation of leukocyte adhesion to vascular endothelial cell</classLabel>
<newAxiom>'negative regulation of leukocyte adhesion to vascular endothelial cell' SubClassOf 'negatively regulates' some 'leukocyte adhesion to vascular endothelial cell'</newAxiom>
<newAxiom>'negative regulation of leukocyte adhesion to vascular endothelial cell' EquivalentTo 'biological regulation' and ('negatively regulates' some 'leukocyte adhesion to vascular endothelial cell')</newAxiom>
<newAxiom>'negative regulation of leukocyte adhesion to vascular endothelial cell' SubClassOf 'negative regulation of leukocyte cell-cell adhesion'</newAxiom>
<newAxiom>'negative regulation of leukocyte adhesion to vascular endothelial cell' SubClassOf 'regulation of leukocyte adhesion to vascular endothelial cell'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904992</classIRI>
<classLabel>positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway</classLabel>
<newAxiom>'positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway' EquivalentTo 'biological regulation' and ('positively regulates' some 'adenylate cyclase-inhibiting dopamine receptor signaling pathway')</newAxiom>
<newAxiom>'positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway' SubClassOf 'regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway'</newAxiom>
<newAxiom>'positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway' SubClassOf 'positively regulates' some 'adenylate cyclase-inhibiting dopamine receptor signaling pathway'</newAxiom>
<newAxiom>'positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway' SubClassOf 'positive regulation of dopamine receptor signaling pathway'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904993</classIRI>
<classLabel>obsolete positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in positive regulation of G2/M transition of mitotic cell cycle</classLabel>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904991</classIRI>
<classLabel>negative regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway</classLabel>
<newAxiom>'negative regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway' EquivalentTo 'biological regulation' and ('negatively regulates' some 'adenylate cyclase-inhibiting dopamine receptor signaling pathway')</newAxiom>
<newAxiom>'negative regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway' SubClassOf 'negatively regulates' some 'adenylate cyclase-inhibiting dopamine receptor signaling pathway'</newAxiom>
<newAxiom>'negative regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway' SubClassOf 'negative regulation of dopamine receptor signaling pathway'</newAxiom>
<newAxiom>'negative regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway' SubClassOf 'regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904990</classIRI>
<classLabel>regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway</classLabel>
<newAxiom>'regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway' SubClassOf 'regulates' some 'adenylate cyclase-inhibiting dopamine receptor signaling pathway'</newAxiom>
<newAxiom>'regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway' SubClassOf 'regulation of dopamine receptor signaling pathway'</newAxiom>
<newAxiom>'regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway' EquivalentTo 'biological regulation' and ('regulates' some 'adenylate cyclase-inhibiting dopamine receptor signaling pathway')</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904989</classIRI>
<classLabel>positive regulation of endothelial cell activation</classLabel>
<newAxiom>'positive regulation of endothelial cell activation' EquivalentTo 'biological regulation' and ('positively regulates' some 'endothelial cell activation')</newAxiom>
<newAxiom>'positive regulation of endothelial cell activation' SubClassOf 'regulation of endothelial cell activation'</newAxiom>
<newAxiom>'positive regulation of endothelial cell activation' SubClassOf 'positively regulates' some 'endothelial cell activation'</newAxiom>
<newAxiom>'positive regulation of endothelial cell activation' SubClassOf 'positive regulation of cell activation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904985</classIRI>
<classLabel>negative regulation of quinolinate biosynthetic process</classLabel>
<newAxiom>'negative regulation of quinolinate biosynthetic process' SubClassOf 'negative regulation of cellular biosynthetic process'</newAxiom>
<newAxiom>'negative regulation of quinolinate biosynthetic process' EquivalentTo 'biological regulation' and ('negatively regulates' some 'quinolinate biosynthetic process')</newAxiom>
<newAxiom>'negative regulation of quinolinate biosynthetic process' SubClassOf 'negatively regulates' some 'quinolinate biosynthetic process'</newAxiom>
<newAxiom>'negative regulation of quinolinate biosynthetic process' SubClassOf 'regulation of quinolinate biosynthetic process'</newAxiom>
<newAxiom>'negative regulation of quinolinate biosynthetic process' SubClassOf 'negative regulation of nitrogen compound metabolic process'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904986</classIRI>
<classLabel>positive regulation of quinolinate biosynthetic process</classLabel>
<newAxiom>'positive regulation of quinolinate biosynthetic process' SubClassOf 'positive regulation of nitrogen compound metabolic process'</newAxiom>
<newAxiom>'positive regulation of quinolinate biosynthetic process' SubClassOf 'positive regulation of cellular biosynthetic process'</newAxiom>
<newAxiom>'positive regulation of quinolinate biosynthetic process' SubClassOf 'positively regulates' some 'quinolinate biosynthetic process'</newAxiom>
<newAxiom>'positive regulation of quinolinate biosynthetic process' SubClassOf 'regulation of quinolinate biosynthetic process'</newAxiom>
<newAxiom>'positive regulation of quinolinate biosynthetic process' EquivalentTo 'biological regulation' and ('positively regulates' some 'quinolinate biosynthetic process')</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904987</classIRI>
<classLabel>regulation of endothelial cell activation</classLabel>
<newAxiom>'regulation of endothelial cell activation' EquivalentTo 'biological regulation' and ('regulates' some 'endothelial cell activation')</newAxiom>
<newAxiom>'regulation of endothelial cell activation' SubClassOf 'regulation of cell activation'</newAxiom>
<newAxiom>'regulation of endothelial cell activation' SubClassOf 'regulates' some 'endothelial cell activation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904988</classIRI>
<classLabel>negative regulation of endothelial cell activation</classLabel>
<newAxiom>'negative regulation of endothelial cell activation' SubClassOf 'regulation of endothelial cell activation'</newAxiom>
<newAxiom>'negative regulation of endothelial cell activation' SubClassOf 'negative regulation of cell activation'</newAxiom>
<newAxiom>'negative regulation of endothelial cell activation' EquivalentTo 'biological regulation' and ('negatively regulates' some 'endothelial cell activation')</newAxiom>
<newAxiom>'negative regulation of endothelial cell activation' SubClassOf 'negatively regulates' some 'endothelial cell activation'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904981</classIRI>
<classLabel>maltose transmembrane transport</classLabel>
<newAxiom>'maltose transmembrane transport' SubClassOf 'maltose transport'</newAxiom>
<newAxiom>'maltose transmembrane transport' SubClassOf 'carbohydrate transmembrane transport'</newAxiom>
<newAxiom>'maltose transmembrane transport' EquivalentTo 'transmembrane transport' and ('transports or maintains localization of' some http://purl.obolibrary.org/obo/CHEBI_17306)</newAxiom>
<newAxiom>'maltose transmembrane transport' SubClassOf 'transports or maintains localization of' some http://purl.obolibrary.org/obo/CHEBI_17306</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904982</classIRI>
<classLabel>sucrose transmembrane transport</classLabel>
<newAxiom>'sucrose transmembrane transport' SubClassOf 'carbohydrate transmembrane transport'</newAxiom>
<newAxiom>'sucrose transmembrane transport' SubClassOf 'sucrose transport'</newAxiom>
<newAxiom>'sucrose transmembrane transport' SubClassOf 'transports or maintains localization of' some http://purl.obolibrary.org/obo/CHEBI_17992</newAxiom>
<newAxiom>'sucrose transmembrane transport' EquivalentTo 'transmembrane transport' and ('transports or maintains localization of' some http://purl.obolibrary.org/obo/CHEBI_17992)</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904983</classIRI>
<classLabel>transmembrane glycine transport from cytosol to mitochondrion</classLabel>
<newAxiom>'transmembrane glycine transport from cytosol to mitochondrion' SubClassOf 'glycine transport'</newAxiom>
<newAxiom>'transmembrane glycine transport from cytosol to mitochondrion' SubClassOf 'has target start location' some 'cytosol'</newAxiom>
<newAxiom>'transmembrane glycine transport from cytosol to mitochondrion' SubClassOf 'transports or maintains localization of' some http://purl.obolibrary.org/obo/CHEBI_15428</newAxiom>
<newAxiom>'transmembrane glycine transport from cytosol to mitochondrion' SubClassOf 'has target end location' some 'mitochondrion'</newAxiom>
<newAxiom>'transmembrane glycine transport from cytosol to mitochondrion' EquivalentTo 'transmembrane transport' and ('transports or maintains localization of' some http://purl.obolibrary.org/obo/CHEBI_15428) and ('has target start location' some 'cytosol') and ('has target end location' some 'mitochondrion')</newAxiom>
<newAxiom>'transmembrane glycine transport from cytosol to mitochondrion' SubClassOf 'L-alpha-amino acid transmembrane transport'</newAxiom>
<newAxiom>'transmembrane glycine transport from cytosol to mitochondrion' SubClassOf 'cation transmembrane transport'</newAxiom>
<newAxiom>'transmembrane glycine transport from cytosol to mitochondrion' SubClassOf 'cytoplasmic transport'</newAxiom>
<newAxiom>'transmembrane glycine transport from cytosol to mitochondrion' SubClassOf 'mitochondrial transmembrane transport'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904984</classIRI>
<classLabel>regulation of quinolinate biosynthetic process</classLabel>
<newAxiom>'regulation of quinolinate biosynthetic process' SubClassOf 'regulates' some 'quinolinate biosynthetic process'</newAxiom>
<newAxiom>'regulation of quinolinate biosynthetic process' SubClassOf 'regulation of nitrogen compound metabolic process'</newAxiom>
<newAxiom>'regulation of quinolinate biosynthetic process' SubClassOf 'regulation of cellular biosynthetic process'</newAxiom>
<newAxiom>'regulation of quinolinate biosynthetic process' EquivalentTo 'biological regulation' and ('regulates' some 'quinolinate biosynthetic process')</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0061757</classIRI>
<classLabel>leukocyte adhesion to arterial endothelial cell</classLabel>
<newAxiom>'leukocyte adhesion to arterial endothelial cell' SubClassOf 'leukocyte adhesion to vascular endothelial cell'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0061754</classIRI>
<classLabel>negative regulation of circulating fibrinogen levels</classLabel>
<newAxiom>'negative regulation of circulating fibrinogen levels' EquivalentTo 'biological regulation' and ('negatively regulates' some http://purl.obolibrary.org/obo/OBA_0000061)</newAxiom>
<newAxiom>'negative regulation of circulating fibrinogen levels' SubClassOf 'regulation of circulating fibrinogen levels'</newAxiom>
<newAxiom>'negative regulation of circulating fibrinogen levels' SubClassOf 'negatively regulates' some http://purl.obolibrary.org/obo/OBA_0000061</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0061756</classIRI>
<classLabel>leukocyte adhesion to vascular endothelial cell</classLabel>
<newAxiom>'leukocyte adhesion to vascular endothelial cell' SubClassOf 'leukocyte cell-cell adhesion'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0061755</classIRI>
<classLabel>positive regulation of circulating fibrinogen levels</classLabel>
<newAxiom>'positive regulation of circulating fibrinogen levels' SubClassOf 'positively regulates' some http://purl.obolibrary.org/obo/OBA_0000061</newAxiom>
<newAxiom>'positive regulation of circulating fibrinogen levels' EquivalentTo 'biological regulation' and ('positively regulates' some http://purl.obolibrary.org/obo/OBA_0000061)</newAxiom>
<newAxiom>'positive regulation of circulating fibrinogen levels' SubClassOf 'regulation of circulating fibrinogen levels'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0099616</classIRI>
<classLabel>extrinsic component of matrix side of mitochondrial inner membrane</classLabel>
<newAxiom>'extrinsic component of matrix side of mitochondrial inner membrane' SubClassOf 'part of' some 'matrix side of mitochondrial inner membrane'</newAxiom>
<newAxiom>'extrinsic component of matrix side of mitochondrial inner membrane' SubClassOf 'extrinsic component of mitochondrial inner membrane'</newAxiom>
<newAxiom>'extrinsic component of matrix side of mitochondrial inner membrane' EquivalentTo 'extrinsic component of membrane' and ('part of' some 'matrix side of mitochondrial inner membrane')</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0099615</classIRI>
<classLabel>(D)-2-hydroxyglutarate-pyruvate transhydrogenase activity</classLabel>
<newAxiom>'(D)-2-hydroxyglutarate-pyruvate transhydrogenase activity' SubClassOf 'oxidoreductase activity, acting on CH-OH group of donors'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0099618</classIRI>
<classLabel>UDP-glucuronic acid dehydrogenase activity</classLabel>
<newAxiom>'UDP-glucuronic acid dehydrogenase activity' SubClassOf 'oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0099617</classIRI>
<classLabel>matrix side of mitochondrial inner membrane</classLabel>
<newAxiom>'matrix side of mitochondrial inner membrane' SubClassOf 'part of' some 'mitochondrial inner membrane'</newAxiom>
<newAxiom>'matrix side of mitochondrial inner membrane' SubClassOf 'lumenal side of membrane'</newAxiom>
<newAxiom>'matrix side of mitochondrial inner membrane' SubClassOf 'adjacent to' some 'mitochondrial matrix'</newAxiom>
<newAxiom>'matrix side of mitochondrial inner membrane' SubClassOf 'mitochondrial membrane part'</newAxiom>
<newAxiom>'matrix side of mitochondrial inner membrane' EquivalentTo 'side of membrane' and ('part of' some 'mitochondrial inner membrane') and ('adjacent to' some 'mitochondrial matrix')</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0099612</classIRI>
<classLabel>protein localization to axon</classLabel>
<newAxiom>'protein localization to axon' SubClassOf 'protein localization'</newAxiom>
<newAxiom>'protein localization to axon' EquivalentTo 'protein localization' and ('has target end location' some 'axon')</newAxiom>
<newAxiom>'protein localization to axon' SubClassOf 'has target end location' some 'axon'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0099614</classIRI>
<classLabel>protein targeting to spore cell wall</classLabel>
<newAxiom>'protein targeting to spore cell wall' SubClassOf 'protein targeting to cell wall'</newAxiom>
<newAxiom>'protein targeting to spore cell wall' SubClassOf 'has target end location' some 'spore wall'</newAxiom>
<newAxiom>'protein targeting to spore cell wall' EquivalentTo 'protein targeting' and ('has target end location' some 'spore wall')</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0099613</classIRI>
<classLabel>protein targeting to cell wall</classLabel>
<newAxiom>'protein targeting to cell wall' SubClassOf 'protein localization to cell periphery'</newAxiom>
<newAxiom>'protein targeting to cell wall' SubClassOf 'has target end location' some 'cell wall'</newAxiom>
<newAxiom>'protein targeting to cell wall' EquivalentTo 'protein targeting' and ('has target end location' some 'cell wall')</newAxiom>
<newAxiom>'protein targeting to cell wall' SubClassOf 'single-organism cellular localization'</newAxiom>
<newAxiom>'protein targeting to cell wall' SubClassOf 'protein targeting'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0099619</classIRI>
<classLabel>UDP-4-amino-4-deoxy-L-arabinose formyltransferase activity</classLabel>
<newAxiom>'UDP-4-amino-4-deoxy-L-arabinose formyltransferase activity' SubClassOf 'hydroxymethyl-, formyl- and related transferase activity'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0099620</classIRI>
<classLabel>UDP-4-amino-4-deoxy-L-arabinose aminotransferase</classLabel>
<newAxiom>'UDP-4-amino-4-deoxy-L-arabinose aminotransferase' SubClassOf 'transaminase activity'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0099621</classIRI>
<classLabel>undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase activity</classLabel>
<newAxiom>'undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase activity' SubClassOf 'transferase activity, transferring pentosyl groups'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0099625</classIRI>
<classLabel>ventricular cardiac muscle cell membrane repolarization</classLabel>
<newAxiom>'ventricular cardiac muscle cell membrane repolarization' SubClassOf 'occurs in' some http://purl.obolibrary.org/obo/CL_0002131</newAxiom>
<newAxiom>'ventricular cardiac muscle cell membrane repolarization' SubClassOf 'membrane repolarization'</newAxiom>
<newAxiom>'ventricular cardiac muscle cell membrane repolarization' SubClassOf 'cardiac muscle cell membrane repolarization'</newAxiom>
<newAxiom>'ventricular cardiac muscle cell membrane repolarization' EquivalentTo 'membrane repolarization' and ('occurs in' some http://purl.obolibrary.org/obo/CL_0002131)</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0099624</classIRI>
<classLabel>atrial cardiac muscle cell membrane repolarization</classLabel>
<newAxiom>'atrial cardiac muscle cell membrane repolarization' SubClassOf 'occurs in' some http://purl.obolibrary.org/obo/CL_0002129</newAxiom>
<newAxiom>'atrial cardiac muscle cell membrane repolarization' SubClassOf 'membrane repolarization'</newAxiom>
<newAxiom>'atrial cardiac muscle cell membrane repolarization' EquivalentTo 'membrane repolarization' and ('occurs in' some http://purl.obolibrary.org/obo/CL_0002129)</newAxiom>
<newAxiom>'atrial cardiac muscle cell membrane repolarization' SubClassOf 'cardiac muscle cell membrane repolarization'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0099623</classIRI>
<classLabel>regulation of cardiac muscle cell membrane repolarization</classLabel>
<newAxiom>'regulation of cardiac muscle cell membrane repolarization' SubClassOf 'regulation of membrane repolarization'</newAxiom>
<newAxiom>'regulation of cardiac muscle cell membrane repolarization' SubClassOf 'regulates' some 'cardiac muscle cell membrane repolarization'</newAxiom>
<newAxiom>'regulation of cardiac muscle cell membrane repolarization' EquivalentTo 'biological regulation' and ('regulates' some 'cardiac muscle cell membrane repolarization')</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0099622</classIRI>
<classLabel>cardiac muscle cell membrane repolarization</classLabel>
<newAxiom>'cardiac muscle cell membrane repolarization' SubClassOf 'occurs in' some http://purl.obolibrary.org/obo/CL_0000746</newAxiom>
<newAxiom>'cardiac muscle cell membrane repolarization' EquivalentTo 'membrane repolarization' and ('occurs in' some http://purl.obolibrary.org/obo/CL_0000746)</newAxiom>
<newAxiom>'cardiac muscle cell membrane repolarization' SubClassOf 'membrane repolarization'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0099600</classIRI>
<classLabel>transmembrane receptor activity</classLabel>
<newAxiom>'transmembrane receptor activity' SubClassOf 'receptor activity'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0099604</classIRI>
<classLabel>ligand-gated calcium channel activity</classLabel>
<newAxiom>'ligand-gated calcium channel activity' EquivalentTo 'ligand-gated channel activity' and ('transports or maintains localization of' some http://purl.obolibrary.org/obo/CHEBI_39123)</newAxiom>
<newAxiom>'ligand-gated calcium channel activity' SubClassOf 'transports or maintains localization of' some http://purl.obolibrary.org/obo/CHEBI_39123</newAxiom>
<newAxiom>'ligand-gated calcium channel activity' SubClassOf 'ligand-gated ion channel activity'</newAxiom>
<newAxiom>'ligand-gated calcium channel activity' SubClassOf 'calcium channel activity'</newAxiom>
<newAxiom>'ligand-gated calcium channel activity' SubClassOf 'transmembrane signaling receptor activity'</newAxiom>
<newAxiom>'ligand-gated calcium channel activity' SubClassOf 'part of' some 'calcium-mediated signaling'</newAxiom>
</newClass>
</newClasses>
<deletedClasses>
<deletedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005218</classIRI>
<classLabel>intracellular ligand-gated calcium channel activity</classLabel>
<newAxiom>'intracellular ligand-gated calcium channel activity' SubClassOf 'calcium-release channel activity'</newAxiom>
<newAxiom>'intracellular ligand-gated calcium channel activity' SubClassOf 'receptor signaling protein activity'</newAxiom>
<newAxiom>'intracellular ligand-gated calcium channel activity' SubClassOf 'intracellular ligand-gated ion channel activity'</newAxiom>
</deletedClass>
<deletedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28812</classIRI>
</deletedClass>
</deletedClasses>
</diffReport>