<?xml version="1.0"?>
<diffReport>
<diffSummary>
<numberChangedClasses>
16
</numberChangedClasses>
<numberNewClasses>
4
</numberNewClasses>
<numberDeletedClasses>
0
</numberDeletedClasses>
</diffSummary>
<changedClasses>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000969</classIRI>
<classLabel>positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity</classLabel>
<deletedAxiom>&apos;positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity&apos; SubClassOf &apos;positive regulation of ion transmembrane transporter activity&apos;</deletedAxiom>
<newAxiom>&apos;positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity&apos; SubClassOf &apos;positive regulation of cation channel activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000311</classIRI>
<classLabel>regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity</classLabel>
<deletedAxiom>&apos;regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity&apos; SubClassOf &apos;regulation of ion transmembrane transporter activity&apos;</deletedAxiom>
<newAxiom>&apos;regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity&apos; SubClassOf &apos;regulation of cation channel activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0004970</classIRI>
<classLabel>ionotropic glutamate receptor activity</classLabel>
<newAxiom>&apos;ionotropic glutamate receptor activity&apos; SubClassOf &apos;voltage-gated cation channel activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0008610</classIRI>
<classLabel>lipid biosynthetic process</classLabel>
<deletedAxiom>&apos;lipid biosynthetic process&apos; SubClassOf &apos;lipid metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;lipid biosynthetic process&apos; SubClassOf &apos;lipid metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904602</classIRI>
<classLabel>serotonin-activated cation-selective channel complex</classLabel>
<deletedAxiom>&apos;serotonin-activated cation-selective channel complex&apos; EquivalentTo &apos;macromolecular complex&apos; and (&apos;capable of&apos; some &apos;serotonin-activated cation-selective channel activity&apos;)</deletedAxiom>
<deletedAxiom>&apos;serotonin-activated cation-selective channel complex&apos; SubClassOf &apos;receptor complex&apos;</deletedAxiom>
<deletedAxiom>&apos;serotonin-activated cation-selective channel complex&apos; SubClassOf &apos;capable of&apos; some &apos;serotonin-activated cation-selective channel activity&apos;</deletedAxiom>
<newAxiom>&apos;serotonin-activated cation-selective channel complex&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0098665</newAxiom>
<newAxiom>&apos;serotonin-activated cation-selective channel complex&apos; SubClassOf &apos;capable of&apos; some &apos;serotonin-gated cation channel activity&apos;</newAxiom>
<newAxiom>&apos;serotonin-activated cation-selective channel complex&apos; EquivalentTo &apos;macromolecular complex&apos; and (&apos;capable of&apos; some &apos;serotonin-gated cation channel activity&apos;)</newAxiom>
<newAxiom>&apos;serotonin-activated cation-selective channel complex&apos; SubClassOf &apos;neurotransmitter receptor complex&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015277</classIRI>
<classLabel>kainate selective glutamate receptor activity</classLabel>
<deletedAxiom>&apos;kainate selective glutamate receptor activity&apos; SubClassOf &apos;potassium channel activity&apos;</deletedAxiom>
<newAxiom>&apos;kainate selective glutamate receptor activity&apos; SubClassOf &apos;voltage-gated potassium channel activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005224</classIRI>
<classLabel>ATP-binding and phosphorylation-dependent chloride channel activity</classLabel>
<deletedAxiom>&apos;ATP-binding and phosphorylation-dependent chloride channel activity&apos; SubClassOf &apos;chloride channel activity&apos;</deletedAxiom>
<deletedAxiom>&apos;ATP-binding and phosphorylation-dependent chloride channel activity&apos; SubClassOf &apos;intracellular ligand-gated ion channel activity&apos;</deletedAxiom>
<deletedAxiom>&apos;ATP-binding and phosphorylation-dependent chloride channel activity&apos; SubClassOf &apos;ligand-gated anion channel activity&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005232</classIRI>
<classLabel>serotonin-activated cation-selective channel activity</classLabel>
<deletedAxiom>&apos;serotonin-activated cation-selective channel activity&apos; SubClassOf &apos;excitatory extracellular ligand-gated ion channel activity&apos;</deletedAxiom>
<deletedAxiom>&apos;serotonin-activated cation-selective channel activity&apos; SubClassOf &apos;cation channel activity&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005260</classIRI>
<classLabel>channel-conductance-controlling ATPase activity</classLabel>
<deletedAxiom>&apos;channel-conductance-controlling ATPase activity&apos; SubClassOf &apos;chloride channel activity&apos;</deletedAxiom>
<deletedAxiom>&apos;channel-conductance-controlling ATPase activity&apos; SubClassOf &apos;ATPase-coupled anion transmembrane transporter activity&apos;</deletedAxiom>
<deletedAxiom>&apos;channel-conductance-controlling ATPase activity&apos; SubClassOf &apos;ATPase activity, coupled to transmembrane movement of substances&apos;</deletedAxiom>
<newAxiom>&apos;channel-conductance-controlling ATPase activity&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099142</newAxiom>
<newAxiom>&apos;channel-conductance-controlling ATPase activity&apos; SubClassOf &apos;chloride channel activity&apos;</newAxiom>
<newAxiom>&apos;channel-conductance-controlling ATPase activity&apos; SubClassOf &apos;ATPase activity&apos;</newAxiom>
<newAxiom>&apos;channel-conductance-controlling ATPase activity&apos; SubClassOf &apos;ligand-gated anion channel activity&apos;</newAxiom>
<newAxiom>&apos;channel-conductance-controlling ATPase activity&apos; SubClassOf &apos;transports or maintains localization of&apos; some http://purl.obolibrary.org/obo/CHEBI_17996</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0007208</classIRI>
<classLabel>phospholipase C-activating serotonin receptor signaling pathway</classLabel>
<deletedAxiom>&apos;phospholipase C-activating serotonin receptor signaling pathway&apos; SubClassOf &apos;serotonin receptor signaling pathway&apos;</deletedAxiom>
<newAxiom>&apos;phospholipase C-activating serotonin receptor signaling pathway&apos; SubClassOf &apos;starts with&apos; some &apos;Gq/11-coupled serotonin receptor activity&apos;</newAxiom>
<newAxiom>&apos;phospholipase C-activating serotonin receptor signaling pathway&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0098664</newAxiom>
<newAxiom>&apos;phospholipase C-activating serotonin receptor signaling pathway&apos; EquivalentTo &apos;signal transduction&apos; and (&apos;starts with&apos; some &apos;Gq/11-coupled serotonin receptor activity&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0007210</classIRI>
<classLabel>serotonin receptor signaling pathway</classLabel>
<deletedAxiom>&apos;serotonin receptor signaling pathway&apos; SubClassOf &apos;G-protein coupled receptor signaling pathway&apos;</deletedAxiom>
<newAxiom>&apos;serotonin receptor signaling pathway&apos; SubClassOf &apos;signal transduction&apos;</newAxiom>
<newAxiom>&apos;serotonin receptor signaling pathway&apos; EquivalentTo &apos;signal transduction&apos; and (&apos;starts with&apos; some &apos;serotonin receptor activity&apos;)</newAxiom>
<newAxiom>&apos;serotonin receptor signaling pathway&apos; SubClassOf &apos;starts with&apos; some &apos;serotonin receptor activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0022850</classIRI>
<classLabel>serotonin-gated cation channel activity</classLabel>
<newAxiom>&apos;serotonin-gated cation channel activity&apos; SubClassOf &apos;cation channel activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0007198</classIRI>
<classLabel>adenylate cyclase-inhibiting serotonin receptor signaling pathway</classLabel>
<deletedAxiom>&apos;adenylate cyclase-inhibiting serotonin receptor signaling pathway&apos; SubClassOf &apos;serotonin receptor signaling pathway&apos;</deletedAxiom>
<newAxiom>&apos;adenylate cyclase-inhibiting serotonin receptor signaling pathway&apos; SubClassOf &apos;starts with&apos; some &apos;Gi/o-coupled serotonin receptor activity&apos;</newAxiom>
<newAxiom>&apos;adenylate cyclase-inhibiting serotonin receptor signaling pathway&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0098664</newAxiom>
<newAxiom>&apos;adenylate cyclase-inhibiting serotonin receptor signaling pathway&apos; EquivalentTo &apos;signal transduction&apos; and (&apos;starts with&apos; some &apos;Gi/o-coupled serotonin receptor activity&apos;)</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0008328</classIRI>
<classLabel>ionotropic glutamate receptor complex</classLabel>
<deletedAxiom>&apos;ionotropic glutamate receptor complex&apos; SubClassOf &apos;ion channel complex&apos;</deletedAxiom>
<newAxiom>&apos;ionotropic glutamate receptor complex&apos; SubClassOf &apos;cation channel complex&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032983</classIRI>
<classLabel>kainate selective glutamate receptor complex</classLabel>
<deletedAxiom>&apos;kainate selective glutamate receptor complex&apos; SubClassOf &apos;potassium channel complex&apos;</deletedAxiom>
<newAxiom>&apos;kainate selective glutamate receptor complex&apos; SubClassOf &apos;voltage-gated potassium channel complex&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0017146</classIRI>
<classLabel>NMDA selective glutamate receptor complex</classLabel>
<deletedAxiom>&apos;NMDA selective glutamate receptor complex&apos; SubClassOf &apos;cation channel complex&apos;</deletedAxiom>
</changedClass>
</changedClasses>
<newClasses>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0098664</classIRI>
<classLabel>G-protein coupled serotonin receptor signaling pathway</classLabel>
<newAxiom>'G-protein coupled serotonin receptor signaling pathway' SubClassOf 'starts with' some 'G-protein coupled serotonin receptor activity'</newAxiom>
<newAxiom>'G-protein coupled serotonin receptor signaling pathway' SubClassOf 'G-protein coupled receptor signaling pathway'</newAxiom>
<newAxiom>'G-protein coupled serotonin receptor signaling pathway' SubClassOf 'serotonin receptor signaling pathway'</newAxiom>
<newAxiom>'G-protein coupled serotonin receptor signaling pathway' EquivalentTo 'signal transduction' and ('starts with' some 'G-protein coupled serotonin receptor activity')</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0098665</classIRI>
<classLabel>serotonin receptor complex</classLabel>
<newAxiom>'serotonin receptor complex' SubClassOf 'receptor complex'</newAxiom>
<newAxiom>'serotonin receptor complex' SubClassOf 'capable of' some 'serotonin receptor activity'</newAxiom>
<newAxiom>'serotonin receptor complex' EquivalentTo 'macromolecular complex' and ('capable of' some 'serotonin receptor activity')</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0098666</classIRI>
<classLabel>G-protein coupled serotonin receptor complex</classLabel>
<newAxiom>'G-protein coupled serotonin receptor complex' SubClassOf 'serotonin receptor complex'</newAxiom>
<newAxiom>'G-protein coupled serotonin receptor complex' EquivalentTo 'macromolecular complex' and ('capable of' some 'G-protein coupled serotonin receptor activity')</newAxiom>
<newAxiom>'G-protein coupled serotonin receptor complex' SubClassOf 'capable of' some 'G-protein coupled serotonin receptor activity'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0099142</classIRI>
<classLabel>intracellular ATP-gated ion channel activity</classLabel>
<newAxiom>'intracellular ATP-gated ion channel activity' SubClassOf 'ATP-gated ion channel activity'</newAxiom>
<newAxiom>'intracellular ATP-gated ion channel activity' SubClassOf 'intracellular ligand-gated ion channel activity'</newAxiom>
</newClass>
</newClasses>
<deletedClasses>
</deletedClasses>
</diffReport>