<?xml version="1.0"?>
<diffReport>
<diffSummary>
<numberChangedClasses>
2729
</numberChangedClasses>
<numberNewClasses>
23
</numberNewClasses>
<numberDeletedClasses>
3
</numberDeletedClasses>
</diffSummary>
<changedClasses>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019262</classIRI>
<classLabel>N-acetylneuraminate catabolic process</classLabel>
<newAxiom>&apos;N-acetylneuraminate catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019260</classIRI>
<classLabel>1,2-dichloroethane catabolic process</classLabel>
<deletedAxiom>&apos;1,2-dichloroethane catabolic process&apos; SubClassOf &apos;chlorinated hydrocarbon catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;1,2-dichloroethane catabolic process&apos; SubClassOf &apos;organic substance catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019261</classIRI>
<classLabel>1,4-dichlorobenzene catabolic process</classLabel>
<newAxiom>&apos;1,4-dichlorobenzene catabolic process&apos; SubClassOf &apos;insecticide catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019270</classIRI>
<classLabel>aerobactin biosynthetic process</classLabel>
<newAxiom>&apos;aerobactin biosynthetic process&apos; SubClassOf &apos;cofactor biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019271</classIRI>
<classLabel>aerobactin transport</classLabel>
<newAxiom>&apos;aerobactin transport&apos; SubClassOf &apos;siderophore transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019295</classIRI>
<classLabel>coenzyme M biosynthetic process</classLabel>
<deletedAxiom>&apos;coenzyme M biosynthetic process&apos; SubClassOf &apos;organic substance biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;coenzyme M biosynthetic process&apos; SubClassOf &apos;organic acid biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019296</classIRI>
<classLabel>coenzyme M metabolic process</classLabel>
<deletedAxiom>&apos;coenzyme M metabolic process&apos; SubClassOf &apos;organic substance metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;coenzyme M metabolic process&apos; SubClassOf &apos;organic acid metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010816</classIRI>
<classLabel>calcitonin catabolic process</classLabel>
<newAxiom>&apos;calcitonin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010815</classIRI>
<classLabel>bradykinin catabolic process</classLabel>
<newAxiom>&apos;bradykinin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_21437</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_21437 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GOCHE_26672</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/GOCHE_26672 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23357</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019182</classIRI>
<classLabel>histamine-gated chloride channel activity</classLabel>
<newAxiom>&apos;histamine-gated chloride channel activity&apos; SubClassOf &apos;ligand-gated anion channel activity&apos;</newAxiom>
<newAxiom>&apos;histamine-gated chloride channel activity&apos; SubClassOf &apos;transmitter-gated channel activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019183</classIRI>
<classLabel>histamine-gated chloride channel complex</classLabel>
<deletedAxiom>&apos;histamine-gated chloride channel complex&apos; SubClassOf &apos;plasma membrane part&apos;</deletedAxiom>
<newAxiom>&apos;histamine-gated chloride channel complex&apos; SubClassOf &apos;neurotransmitter receptor complex&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_5870</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_5870 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52210</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_5870 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_5870 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35703</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_5870 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24852</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_5870 SubClassOf http://purl.obolibrary.org/obo/GOCHE_64909</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_5870 SubClassOf http://purl.obolibrary.org/obo/GOCHE_51086</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_45373</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_45373 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_21397</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_21397 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_60983</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_60983 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_21398</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_21398 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_60963</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_60963 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24432</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_60951</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_60951 SubClassOf http://purl.obolibrary.org/obo/GOCHE_26115</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_60952</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_60952 SubClassOf http://purl.obolibrary.org/obo/GOCHE_26115</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_35998</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_35998 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_60943</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_60943 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010726</classIRI>
<classLabel>positive regulation of hydrogen peroxide metabolic process</classLabel>
<newAxiom>&apos;positive regulation of hydrogen peroxide metabolic process&apos; SubClassOf &apos;positive regulation of cofactor metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010727</classIRI>
<classLabel>negative regulation of hydrogen peroxide metabolic process</classLabel>
<newAxiom>&apos;negative regulation of hydrogen peroxide metabolic process&apos; SubClassOf &apos;negative regulation of cofactor metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_21336</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_21336 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009751</classIRI>
<classLabel>response to salicylic acid</classLabel>
<newAxiom>&apos;response to salicylic acid&apos; SubClassOf &apos;response to hormone&apos;</newAxiom>
<newAxiom>&apos;response to salicylic acid&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_59908</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_59908 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_59905</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_59905 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_35940</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_35940 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_35907</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_35907 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0034650</classIRI>
<classLabel>cortisol metabolic process</classLabel>
<newAxiom>&apos;cortisol metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0020037</classIRI>
<classLabel>heme binding</classLabel>
<newAxiom>&apos;heme binding&apos; SubClassOf &apos;cofactor binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0034697</classIRI>
<classLabel>response to prostaglandin I</classLabel>
<newAxiom>&apos;response to prostaglandin I&apos; SubClassOf &apos;response to organic cyclic compound&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_31014</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_31014 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_31011</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_31011 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0034617</classIRI>
<classLabel>tetrahydrobiopterin binding</classLabel>
<newAxiom>&apos;tetrahydrobiopterin binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0034634</classIRI>
<classLabel>glutathione transmembrane transporter activity</classLabel>
<newAxiom>&apos;glutathione transmembrane transporter activity&apos; SubClassOf &apos;cofactor transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0034635</classIRI>
<classLabel>glutathione transport</classLabel>
<newAxiom>&apos;glutathione transport&apos; SubClassOf &apos;cofactor transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009685</classIRI>
<classLabel>gibberellin metabolic process</classLabel>
<newAxiom>&apos;gibberellin metabolic process&apos; SubClassOf &apos;hormone metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009686</classIRI>
<classLabel>gibberellin biosynthetic process</classLabel>
<newAxiom>&apos;gibberellin biosynthetic process&apos; SubClassOf &apos;hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009694</classIRI>
<classLabel>jasmonic acid metabolic process</classLabel>
<newAxiom>&apos;jasmonic acid metabolic process&apos; SubClassOf &apos;hormone metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009695</classIRI>
<classLabel>jasmonic acid biosynthetic process</classLabel>
<newAxiom>&apos;jasmonic acid biosynthetic process&apos; SubClassOf &apos;hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009692</classIRI>
<classLabel>ethylene metabolic process</classLabel>
<newAxiom>&apos;ethylene metabolic process&apos; SubClassOf &apos;hormone metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009693</classIRI>
<classLabel>ethylene biosynthetic process</classLabel>
<newAxiom>&apos;ethylene biosynthetic process&apos; SubClassOf &apos;hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009696</classIRI>
<classLabel>salicylic acid metabolic process</classLabel>
<newAxiom>&apos;salicylic acid metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
<newAxiom>&apos;salicylic acid metabolic process&apos; SubClassOf &apos;hormone metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009697</classIRI>
<classLabel>salicylic acid biosynthetic process</classLabel>
<newAxiom>&apos;salicylic acid biosynthetic process&apos; SubClassOf &apos;hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_21547</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_21547 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_21547 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0034516</classIRI>
<classLabel>response to vitamin B6</classLabel>
<newAxiom>&apos;response to vitamin B6&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0034465</classIRI>
<classLabel>response to carbon monoxide</classLabel>
<newAxiom>&apos;response to carbon monoxide&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
<newAxiom>&apos;response to carbon monoxide&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_5533</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_5533 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35610</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_5533 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_60584</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_60584 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_60584 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_21054</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_21054 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_59640</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_59640 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009441</classIRI>
<classLabel>glycolate metabolic process</classLabel>
<newAxiom>&apos;glycolate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009449</classIRI>
<classLabel>gamma-aminobutyric acid biosynthetic process</classLabel>
<newAxiom>&apos;gamma-aminobutyric acid biosynthetic process&apos; SubClassOf &apos;neurotransmitter biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009448</classIRI>
<classLabel>gamma-aminobutyric acid metabolic process</classLabel>
<newAxiom>&apos;gamma-aminobutyric acid metabolic process&apos; SubClassOf &apos;neurotransmitter metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009450</classIRI>
<classLabel>gamma-aminobutyric acid catabolic process</classLabel>
<newAxiom>&apos;gamma-aminobutyric acid catabolic process&apos; SubClassOf &apos;neurotransmitter catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010337</classIRI>
<classLabel>regulation of salicylic acid metabolic process</classLabel>
<newAxiom>&apos;regulation of salicylic acid metabolic process&apos; SubClassOf &apos;regulation of hormone metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010364</classIRI>
<classLabel>regulation of ethylene biosynthetic process</classLabel>
<deletedAxiom>&apos;regulation of ethylene biosynthetic process&apos; SubClassOf &apos;regulation of cellular biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;regulation of ethylene biosynthetic process&apos; SubClassOf &apos;regulation of hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010365</classIRI>
<classLabel>positive regulation of ethylene biosynthetic process</classLabel>
<deletedAxiom>&apos;positive regulation of ethylene biosynthetic process&apos; SubClassOf &apos;positive regulation of cellular biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;positive regulation of ethylene biosynthetic process&apos; SubClassOf &apos;positive regulation of hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010366</classIRI>
<classLabel>negative regulation of ethylene biosynthetic process</classLabel>
<deletedAxiom>&apos;negative regulation of ethylene biosynthetic process&apos; SubClassOf &apos;negative regulation of cellular biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of ethylene biosynthetic process&apos; SubClassOf &apos;negative regulation of hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009374</classIRI>
<classLabel>biotin binding</classLabel>
<newAxiom>&apos;biotin binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
<newAxiom>&apos;biotin binding&apos; SubClassOf &apos;coenzyme binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010371</classIRI>
<classLabel>regulation of gibberellin biosynthetic process</classLabel>
<deletedAxiom>&apos;regulation of gibberellin biosynthetic process&apos; SubClassOf &apos;regulation of cellular biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;regulation of gibberellin biosynthetic process&apos; SubClassOf &apos;regulation of hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010372</classIRI>
<classLabel>positive regulation of gibberellin biosynthetic process</classLabel>
<deletedAxiom>&apos;positive regulation of gibberellin biosynthetic process&apos; SubClassOf &apos;positive regulation of cellular biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;positive regulation of gibberellin biosynthetic process&apos; SubClassOf &apos;positive regulation of hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010373</classIRI>
<classLabel>negative regulation of gibberellin biosynthetic process</classLabel>
<deletedAxiom>&apos;negative regulation of gibberellin biosynthetic process&apos; SubClassOf &apos;negative regulation of cellular biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of gibberellin biosynthetic process&apos; SubClassOf &apos;negative regulation of hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0000954</classIRI>
<classLabel>methionine catabolic process to 3-methylthiopropanoate</classLabel>
<newAxiom>&apos;methionine catabolic process to 3-methylthiopropanoate&apos; SubClassOf &apos;toxin biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010391</classIRI>
<classLabel>glucomannan metabolic process</classLabel>
<newAxiom>&apos;glucomannan metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_60471</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_60471 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_5445</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_5445 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
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<classIRI>http://purl.obolibrary.org/obo/CHEBI_16183</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16183 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16183 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33232</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16183 SubClassOf http://purl.obolibrary.org/obo/CHEBI_138675</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16183 SubClassOf http://purl.obolibrary.org/obo/GOCHE_51086</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_9973</classIRI>
<deletedAxiom>http://purl.obolibrary.org/obo/CHEBI_9973 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24028</deletedAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_9973 SubClassOf http://purl.obolibrary.org/obo/GOCHE_26672</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_70816</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_70816 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_70816 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_70816 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1990054</classIRI>
<classLabel>response to temozolomide</classLabel>
<newAxiom>&apos;response to temozolomide&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0000297</classIRI>
<classLabel>spermine transmembrane transporter activity</classLabel>
<newAxiom>&apos;spermine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0000296</classIRI>
<classLabel>spermine transport</classLabel>
<newAxiom>&apos;spermine transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0000255</classIRI>
<classLabel>allantoin metabolic process</classLabel>
<newAxiom>&apos;allantoin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0000256</classIRI>
<classLabel>allantoin catabolic process</classLabel>
<newAxiom>&apos;allantoin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0097160</classIRI>
<classLabel>polychlorinated biphenyl binding</classLabel>
<newAxiom>&apos;polychlorinated biphenyl binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_45863</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_45863 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52210</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_45863 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35610</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_45863 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_70726</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_70726 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_70723</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_70723 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_70723 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35610</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_70723 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52210</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_70773</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_70773 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52210</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_70778</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_70778 SubClassOf http://purl.obolibrary.org/obo/GOCHE_48705</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0000095</classIRI>
<classLabel>S-adenosyl-L-methionine transmembrane transporter activity</classLabel>
<newAxiom>&apos;S-adenosyl-L-methionine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_79057</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_79057 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_79070</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_79070 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_79071</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_79071 SubClassOf http://purl.obolibrary.org/obo/GOCHE_51086</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_79071 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0097054</classIRI>
<classLabel>L-glutamate biosynthetic process</classLabel>
<newAxiom>&apos;L-glutamate biosynthetic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
<newAxiom>&apos;L-glutamate biosynthetic process&apos; SubClassOf &apos;neurotransmitter metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0097061</classIRI>
<classLabel>dendritic spine organization</classLabel>
<newAxiom>&apos;dendritic spine organization&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099173</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0097068</classIRI>
<classLabel>response to thyroxine</classLabel>
<newAxiom>&apos;response to thyroxine&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0097069</classIRI>
<classLabel>cellular response to thyroxine stimulus</classLabel>
<newAxiom>&apos;cellular response to thyroxine stimulus&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_45725</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_45725 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000907</classIRI>
<classLabel>negative regulation of glucomannan catabolic process</classLabel>
<deletedAxiom>&apos;negative regulation of glucomannan catabolic process&apos; SubClassOf &apos;negative regulation of catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of glucomannan catabolic process&apos; SubClassOf &apos;negative regulation of cellular catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0000064</classIRI>
<classLabel>L-ornithine transmembrane transporter activity</classLabel>
<newAxiom>&apos;L-ornithine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000884</classIRI>
<classLabel>glucomannan catabolic process</classLabel>
<newAxiom>&apos;glucomannan catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000898</classIRI>
<classLabel>regulation of glucomannan catabolic process</classLabel>
<newAxiom>&apos;regulation of glucomannan catabolic process&apos; SubClassOf &apos;regulation of cellular catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000864</classIRI>
<classLabel>regulation of estradiol secretion</classLabel>
<deletedAxiom>&apos;regulation of estradiol secretion&apos; SubClassOf &apos;regulation of secretion&apos;</deletedAxiom>
<newAxiom>&apos;regulation of estradiol secretion&apos; SubClassOf &apos;regulation of hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000865</classIRI>
<classLabel>negative regulation of estradiol secretion</classLabel>
<deletedAxiom>&apos;negative regulation of estradiol secretion&apos; SubClassOf &apos;negative regulation of secretion&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of estradiol secretion&apos; SubClassOf &apos;negative regulation of hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000868</classIRI>
<classLabel>negative regulation of estrone secretion</classLabel>
<deletedAxiom>&apos;negative regulation of estrone secretion&apos; SubClassOf &apos;negative regulation of secretion&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of estrone secretion&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
<newAxiom>&apos;negative regulation of estrone secretion&apos; SubClassOf &apos;negative regulation of hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000869</classIRI>
<classLabel>positive regulation of estrone secretion</classLabel>
<deletedAxiom>&apos;positive regulation of estrone secretion&apos; SubClassOf &apos;positive regulation of secretion&apos;</deletedAxiom>
<newAxiom>&apos;positive regulation of estrone secretion&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
<newAxiom>&apos;positive regulation of estrone secretion&apos; SubClassOf &apos;positive regulation of hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000866</classIRI>
<classLabel>positive regulation of estradiol secretion</classLabel>
<deletedAxiom>&apos;positive regulation of estradiol secretion&apos; SubClassOf &apos;positive regulation of secretion&apos;</deletedAxiom>
<newAxiom>&apos;positive regulation of estradiol secretion&apos; SubClassOf &apos;positive regulation of hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000867</classIRI>
<classLabel>regulation of estrone secretion</classLabel>
<deletedAxiom>&apos;regulation of estrone secretion&apos; SubClassOf &apos;regulation of secretion&apos;</deletedAxiom>
<newAxiom>&apos;regulation of estrone secretion&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
<newAxiom>&apos;regulation of estrone secretion&apos; SubClassOf &apos;regulation of hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000871</classIRI>
<classLabel>negative regulation of progesterone secretion</classLabel>
<newAxiom>&apos;negative regulation of progesterone secretion&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000872</classIRI>
<classLabel>positive regulation of progesterone secretion</classLabel>
<newAxiom>&apos;positive regulation of progesterone secretion&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000870</classIRI>
<classLabel>regulation of progesterone secretion</classLabel>
<newAxiom>&apos;regulation of progesterone secretion&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_31463</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_31463 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000842</classIRI>
<classLabel>positive regulation of dehydroepiandrosterone secretion</classLabel>
<deletedAxiom>&apos;positive regulation of dehydroepiandrosterone secretion&apos; SubClassOf &apos;positive regulation of secretion&apos;</deletedAxiom>
<newAxiom>&apos;positive regulation of dehydroepiandrosterone secretion&apos; SubClassOf &apos;positive regulation of hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000843</classIRI>
<classLabel>regulation of testosterone secretion</classLabel>
<deletedAxiom>&apos;regulation of testosterone secretion&apos; SubClassOf &apos;regulation of secretion&apos;</deletedAxiom>
<newAxiom>&apos;regulation of testosterone secretion&apos; SubClassOf &apos;regulation of hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000840</classIRI>
<classLabel>regulation of dehydroepiandrosterone secretion</classLabel>
<deletedAxiom>&apos;regulation of dehydroepiandrosterone secretion&apos; SubClassOf &apos;regulation of secretion&apos;</deletedAxiom>
<newAxiom>&apos;regulation of dehydroepiandrosterone secretion&apos; SubClassOf &apos;regulation of hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000841</classIRI>
<classLabel>negative regulation of dehydroepiandrosterone secretion</classLabel>
<deletedAxiom>&apos;negative regulation of dehydroepiandrosterone secretion&apos; SubClassOf &apos;negative regulation of secretion&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of dehydroepiandrosterone secretion&apos; SubClassOf &apos;negative regulation of hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000844</classIRI>
<classLabel>negative regulation of testosterone secretion</classLabel>
<deletedAxiom>&apos;negative regulation of testosterone secretion&apos; SubClassOf &apos;negative regulation of secretion&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of testosterone secretion&apos; SubClassOf &apos;negative regulation of hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000845</classIRI>
<classLabel>positive regulation of testosterone secretion</classLabel>
<deletedAxiom>&apos;positive regulation of testosterone secretion&apos; SubClassOf &apos;positive regulation of secretion&apos;</deletedAxiom>
<newAxiom>&apos;positive regulation of testosterone secretion&apos; SubClassOf &apos;positive regulation of hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_45931</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_45931 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000839</classIRI>
<classLabel>positive regulation of androstenedione secretion</classLabel>
<deletedAxiom>&apos;positive regulation of androstenedione secretion&apos; SubClassOf &apos;positive regulation of secretion&apos;</deletedAxiom>
<newAxiom>&apos;positive regulation of androstenedione secretion&apos; SubClassOf &apos;positive regulation of hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000837</classIRI>
<classLabel>regulation of androstenedione secretion</classLabel>
<deletedAxiom>&apos;regulation of androstenedione secretion&apos; SubClassOf &apos;regulation of secretion&apos;</deletedAxiom>
<newAxiom>&apos;regulation of androstenedione secretion&apos; SubClassOf &apos;regulation of hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000838</classIRI>
<classLabel>negative regulation of androstenedione secretion</classLabel>
<deletedAxiom>&apos;negative regulation of androstenedione secretion&apos; SubClassOf &apos;negative regulation of secretion&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of androstenedione secretion&apos; SubClassOf &apos;negative regulation of hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_45906</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_45906 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_45906 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_79316</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_79316 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GOCHE_22582</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/GOCHE_22582 SubClassOf http://purl.obolibrary.org/obo/GOCHE_27026</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_45996</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_45996 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_31355</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_31355 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24432</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_31355 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35610</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_45979</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_45979 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_9516</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_9516 SubClassOf http://purl.obolibrary.org/obo/GOCHE_38632</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_9516 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_64543</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_64543 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_64535</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_64535 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_64534</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_64534 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35610</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_64531 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25442</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_64530</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_64530 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_64522</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_64522 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_15595 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_64512 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_64518</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_64518 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35610</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_64518 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_64518 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_64502 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_64502 SubClassOf http://purl.obolibrary.org/obo/GOCHE_26013</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_64503 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
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</changedClass>
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</changedClass>
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</changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_15346 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23354</newAxiom>
</changedClass>
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</changedClass>
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</changedClass>
<changedClass>
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</changedClass>
<changedClass>
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</changedClass>
<changedClass>
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</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_30911 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_30929 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_30921 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000082</classIRI>
<classLabel>regulation of L-ascorbic acid biosynthetic process</classLabel>
<newAxiom>&apos;regulation of L-ascorbic acid biosynthetic process&apos; SubClassOf &apos;regulation of coenzyme metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000083</classIRI>
<classLabel>negative regulation of L-ascorbic acid biosynthetic process</classLabel>
<newAxiom>&apos;negative regulation of L-ascorbic acid biosynthetic process&apos; SubClassOf &apos;negative regulation of coenzyme metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_29919</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_29919 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018970</classIRI>
<classLabel>toluene metabolic process</classLabel>
<newAxiom>&apos;toluene metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018977</classIRI>
<classLabel>1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process</classLabel>
<newAxiom>&apos;1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018979</classIRI>
<classLabel>trichloroethylene metabolic process</classLabel>
<newAxiom>&apos;trichloroethylene metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000031</classIRI>
<classLabel>regulation of salicylic acid mediated signaling pathway</classLabel>
<newAxiom>&apos;regulation of salicylic acid mediated signaling pathway&apos; SubClassOf &apos;regulation of cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_609827</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_609827 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24852</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0043924</classIRI>
<classLabel>suramin binding</classLabel>
<newAxiom>&apos;suramin binding&apos; SubClassOf &apos;organic acid binding&apos;</newAxiom>
<newAxiom>&apos;suramin binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018980</classIRI>
<classLabel>2,4,5-trichlorophenoxyacetic acid metabolic process</classLabel>
<newAxiom>&apos;2,4,5-trichlorophenoxyacetic acid metabolic process&apos; SubClassOf &apos;xenobiotic metabolic process&apos;</newAxiom>
<newAxiom>&apos;2,4,5-trichlorophenoxyacetic acid metabolic process&apos; SubClassOf &apos;auxin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018982</classIRI>
<classLabel>vanillin metabolic process</classLabel>
<newAxiom>&apos;vanillin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018984</classIRI>
<classLabel>naphthalenesulfonate metabolic process</classLabel>
<deletedAxiom>&apos;naphthalenesulfonate metabolic process&apos; SubClassOf &apos;organic substance metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;naphthalenesulfonate metabolic process&apos; SubClassOf &apos;organic acid metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901149</classIRI>
<classLabel>salicylic acid binding</classLabel>
<newAxiom>&apos;salicylic acid binding&apos; SubClassOf &apos;hormone binding&apos;</newAxiom>
<newAxiom>&apos;salicylic acid binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901113</classIRI>
<classLabel>erythromycin metabolic process</classLabel>
<newAxiom>&apos;erythromycin metabolic process&apos; SubClassOf &apos;xenobiotic metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901114</classIRI>
<classLabel>erythromycin catabolic process</classLabel>
<newAxiom>&apos;erythromycin catabolic process&apos; SubClassOf &apos;xenobiotic catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901119</classIRI>
<classLabel>tobramycin metabolic process</classLabel>
<newAxiom>&apos;tobramycin metabolic process&apos; SubClassOf &apos;toxin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901120</classIRI>
<classLabel>tobramycin catabolic process</classLabel>
<newAxiom>&apos;tobramycin catabolic process&apos; SubClassOf &apos;toxin catabolic process&apos;</newAxiom>
<newAxiom>&apos;tobramycin catabolic process&apos; SubClassOf &apos;detoxification of nitrogen compound&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901121</classIRI>
<classLabel>tobramycin biosynthetic process</classLabel>
<newAxiom>&apos;tobramycin biosynthetic process&apos; SubClassOf &apos;toxin biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901125</classIRI>
<classLabel>candicidin metabolic process</classLabel>
<newAxiom>&apos;candicidin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901126</classIRI>
<classLabel>candicidin catabolic process</classLabel>
<newAxiom>&apos;candicidin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901170</classIRI>
<classLabel>naphthalene catabolic process</classLabel>
<newAxiom>&apos;naphthalene catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901181</classIRI>
<classLabel>negative regulation of cellular response to caffeine</classLabel>
<deletedAxiom>&apos;negative regulation of cellular response to caffeine&apos; SubClassOf &apos;negative regulation of response to stimulus&apos;</deletedAxiom>
<deletedAxiom>&apos;negative regulation of cellular response to caffeine&apos; SubClassOf &apos;negative regulation of cellular process&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of cellular response to caffeine&apos; SubClassOf &apos;negative regulation of cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901150</classIRI>
<classLabel>vistamycin metabolic process</classLabel>
<newAxiom>&apos;vistamycin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901151</classIRI>
<classLabel>vistamycin catabolic process</classLabel>
<newAxiom>&apos;vistamycin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901153</classIRI>
<classLabel>paromomycin metabolic process</classLabel>
<newAxiom>&apos;paromomycin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901154</classIRI>
<classLabel>paromomycin catabolic process</classLabel>
<newAxiom>&apos;paromomycin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_78903 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_64397 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35610</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_64397 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_64398 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_64372 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_39258 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_40235</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_40235 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35610</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_30887 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_30853</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_30853 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_30853 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_30854 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_30851 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_30851 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33232</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_30852 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_30860</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_30860 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_30861</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_30861 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_30839</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_30839 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_30837</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_30837 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_30833</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_30833 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_30832</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_30832 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33232</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_30832 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52211</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_30832 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_30830</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_30830 SubClassOf http://purl.obolibrary.org/obo/GOCHE_64909</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_30830 SubClassOf http://purl.obolibrary.org/obo/GOCHE_38867</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_30830 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35488</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_30830 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52210</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018900</classIRI>
<classLabel>dichloromethane metabolic process</classLabel>
<deletedAxiom>&apos;dichloromethane metabolic process&apos; SubClassOf &apos;chlorinated hydrocarbon metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;dichloromethane metabolic process&apos; SubClassOf &apos;organic substance metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018901</classIRI>
<classLabel>2,4-dichlorophenoxyacetic acid metabolic process</classLabel>
<newAxiom>&apos;2,4-dichlorophenoxyacetic acid metabolic process&apos; SubClassOf &apos;xenobiotic metabolic process&apos;</newAxiom>
<newAxiom>&apos;2,4-dichlorophenoxyacetic acid metabolic process&apos; SubClassOf &apos;auxin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_29864</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_29864 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018912</classIRI>
<classLabel>1,4-dichlorobenzene metabolic process</classLabel>
<newAxiom>&apos;1,4-dichlorobenzene metabolic process&apos; SubClassOf &apos;insecticide metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018907</classIRI>
<classLabel>dimethyl sulfoxide metabolic process</classLabel>
<newAxiom>&apos;dimethyl sulfoxide metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_30823</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_30823 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018917</classIRI>
<classLabel>fluorene metabolic process</classLabel>
<newAxiom>&apos;fluorene metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018918</classIRI>
<classLabel>gallate metabolic process</classLabel>
<newAxiom>&apos;gallate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018919</classIRI>
<classLabel>gamma-1,2,3,4,5,6-hexachlorocyclohexane metabolic process</classLabel>
<newAxiom>&apos;gamma-1,2,3,4,5,6-hexachlorocyclohexane metabolic process&apos; SubClassOf &apos;insecticide metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_29806</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_29806 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018930</classIRI>
<classLabel>3-methylquinoline metabolic process</classLabel>
<newAxiom>&apos;3-methylquinoline metabolic process&apos; SubClassOf &apos;xenobiotic metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018931</classIRI>
<classLabel>naphthalene metabolic process</classLabel>
<newAxiom>&apos;naphthalene metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018933</classIRI>
<classLabel>nicotine metabolic process</classLabel>
<deletedAxiom>&apos;nicotine metabolic process&apos; SubClassOf &apos;metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;nicotine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_30807</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_30807 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_30805</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_30805 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_30805 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_30800</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_30800 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018937</classIRI>
<classLabel>nitroglycerin metabolic process</classLabel>
<newAxiom>&apos;nitroglycerin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018938</classIRI>
<classLabel>2-nitropropane metabolic process</classLabel>
<newAxiom>&apos;2-nitropropane metabolic process&apos; SubClassOf &apos;organic substance metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018952</classIRI>
<classLabel>parathion metabolic process</classLabel>
<newAxiom>&apos;parathion metabolic process&apos; SubClassOf &apos;insecticide metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018954</classIRI>
<classLabel>pentaerythritol tetranitrate metabolic process</classLabel>
<newAxiom>&apos;pentaerythritol tetranitrate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018955</classIRI>
<classLabel>phenanthrene metabolic process</classLabel>
<newAxiom>&apos;phenanthrene metabolic process&apos; SubClassOf &apos;xenobiotic metabolic process&apos;</newAxiom>
<newAxiom>&apos;phenanthrene metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901322</classIRI>
<classLabel>response to chloramphenicol</classLabel>
<newAxiom>&apos;response to chloramphenicol&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901323</classIRI>
<classLabel>response to erythromycin</classLabel>
<newAxiom>&apos;response to erythromycin&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901324</classIRI>
<classLabel>response to trichodermin</classLabel>
<newAxiom>&apos;response to trichodermin&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901326</classIRI>
<classLabel>response to tetracycline</classLabel>
<newAxiom>&apos;response to tetracycline&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901327</classIRI>
<classLabel>response to tacrolimus</classLabel>
<deletedAxiom>&apos;response to tacrolimus&apos; SubClassOf &apos;response to chemical&apos;</deletedAxiom>
<newAxiom>&apos;response to tacrolimus&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901328</classIRI>
<classLabel>response to cytochalasin B</classLabel>
<newAxiom>&apos;response to cytochalasin B&apos; SubClassOf &apos;response to platelet aggregation inhibitor&apos;</newAxiom>
<newAxiom>&apos;response to cytochalasin B&apos; SubClassOf &apos;response to mycotoxin&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_29805</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_29805 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901267</classIRI>
<classLabel>cephalosporin C catabolic process</classLabel>
<newAxiom>&apos;cephalosporin C catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018874</classIRI>
<classLabel>benzoate metabolic process</classLabel>
<newAxiom>&apos;benzoate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901235</classIRI>
<classLabel>(R)-carnitine transmembrane transporter activity</classLabel>
<newAxiom>&apos;(R)-carnitine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
<newAxiom>&apos;(R)-carnitine transmembrane transporter activity&apos; SubClassOf &apos;vitamin transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018881</classIRI>
<classLabel>bromoxynil metabolic process</classLabel>
<newAxiom>&apos;bromoxynil metabolic process&apos; SubClassOf &apos;xenobiotic metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018885</classIRI>
<classLabel>carbon tetrachloride metabolic process</classLabel>
<deletedAxiom>&apos;carbon tetrachloride metabolic process&apos; SubClassOf &apos;chlorinated hydrocarbon metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;carbon tetrachloride metabolic process&apos; SubClassOf &apos;organic substance metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018889</classIRI>
<classLabel>2-chloro-N-isopropylacetanilide metabolic process</classLabel>
<newAxiom>&apos;2-chloro-N-isopropylacetanilide metabolic process&apos; SubClassOf &apos;xenobiotic metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018893</classIRI>
<classLabel>dibenzofuran metabolic process</classLabel>
<newAxiom>&apos;dibenzofuran metabolic process&apos; SubClassOf &apos;xenobiotic metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018894</classIRI>
<classLabel>dibenzo-p-dioxin metabolic process</classLabel>
<newAxiom>&apos;dibenzo-p-dioxin metabolic process&apos; SubClassOf &apos;xenobiotic metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018895</classIRI>
<classLabel>dibenzothiophene metabolic process</classLabel>
<newAxiom>&apos;dibenzothiophene metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018896</classIRI>
<classLabel>dibenzothiophene catabolic process</classLabel>
<newAxiom>&apos;dibenzothiophene catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018899</classIRI>
<classLabel>1,2-dichloroethane metabolic process</classLabel>
<deletedAxiom>&apos;1,2-dichloroethane metabolic process&apos; SubClassOf &apos;chlorinated hydrocarbon metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;1,2-dichloroethane metabolic process&apos; SubClassOf &apos;organic substance metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_9168</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_9168 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35610</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_9168 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_9168 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0043879</classIRI>
<classLabel>glycolate transmembrane transporter activity</classLabel>
<newAxiom>&apos;glycolate transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_64272</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_64272 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_64271</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_64271 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_78802</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_78802 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_64250</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_64250 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_64256</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_64256 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_64257</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_64257 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_64255</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_64255 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_78812</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_78812 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_78812 SubClassOf http://purl.obolibrary.org/obo/GOCHE_26013</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_64248</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_64248 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_64245</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_64245 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_64246</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_64246 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_64243</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_64243 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33232</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_64243 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52211</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_64228</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_64228 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_39281</classIRI>
<deletedAxiom>http://purl.obolibrary.org/obo/CHEBI_39281 SubClassOf http://purl.obolibrary.org/obo/CHEBI_37143</deletedAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_39281 SubClassOf http://purl.obolibrary.org/obo/CHEBI_24067</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_35194</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_35194 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901413</classIRI>
<classLabel>regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA</classLabel>
<newAxiom>&apos;regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA&apos; SubClassOf &apos;regulation of neurotransmitter levels&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901416</classIRI>
<classLabel>regulation of response to ethanol</classLabel>
<newAxiom>&apos;regulation of response to ethanol&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901417</classIRI>
<classLabel>negative regulation of response to ethanol</classLabel>
<newAxiom>&apos;negative regulation of response to ethanol&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901418</classIRI>
<classLabel>positive regulation of response to ethanol</classLabel>
<newAxiom>&apos;positive regulation of response to ethanol&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_60119</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_60119 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901424</classIRI>
<classLabel>response to toluene</classLabel>
<newAxiom>&apos;response to toluene&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
<newAxiom>&apos;response to toluene&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901425</classIRI>
<classLabel>response to formic acid</classLabel>
<newAxiom>&apos;response to formic acid&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901454</classIRI>
<classLabel>regulation of response to toluene</classLabel>
<deletedAxiom>&apos;regulation of response to toluene&apos; SubClassOf &apos;regulation of response to stimulus&apos;</deletedAxiom>
<newAxiom>&apos;regulation of response to toluene&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901455</classIRI>
<classLabel>negative regulation of response to toluene</classLabel>
<deletedAxiom>&apos;negative regulation of response to toluene&apos; SubClassOf &apos;negative regulation of response to stimulus&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of response to toluene&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901456</classIRI>
<classLabel>positive regulation of response to toluene</classLabel>
<deletedAxiom>&apos;positive regulation of response to toluene&apos; SubClassOf &apos;positive regulation of response to stimulus&apos;</deletedAxiom>
<newAxiom>&apos;positive regulation of response to toluene&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901460</classIRI>
<classLabel>regulation of response to formic acid</classLabel>
<deletedAxiom>&apos;regulation of response to formic acid&apos; SubClassOf &apos;regulation of response to stimulus&apos;</deletedAxiom>
<newAxiom>&apos;regulation of response to formic acid&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901461</classIRI>
<classLabel>negative regulation of response to formic acid</classLabel>
<deletedAxiom>&apos;negative regulation of response to formic acid&apos; SubClassOf &apos;negative regulation of response to stimulus&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of response to formic acid&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901462</classIRI>
<classLabel>positive regulation of response to formic acid</classLabel>
<deletedAxiom>&apos;positive regulation of response to formic acid&apos; SubClassOf &apos;positive regulation of response to stimulus&apos;</deletedAxiom>
<newAxiom>&apos;positive regulation of response to formic acid&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901354</classIRI>
<classLabel>response to L-canavanine</classLabel>
<newAxiom>&apos;response to L-canavanine&apos; SubClassOf &apos;response to insecticide&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901355</classIRI>
<classLabel>response to rapamycin</classLabel>
<newAxiom>&apos;response to rapamycin&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_25879</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_25879 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_25879 SubClassOf http://purl.obolibrary.org/obo/GOCHE_51086</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_25848</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_25848 SubClassOf http://purl.obolibrary.org/obo/GOCHE_27314</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_25848 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23357</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_25863</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_25863 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_25805</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_25805 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33284</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_25812</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_25812 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_25812 SubClassOf http://purl.obolibrary.org/obo/CHEBI_138675</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_25812 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_25822</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_25822 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_60065</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_60065 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_59062</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_59062 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_50648</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_50648 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35610</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_50648 SubClassOf http://purl.obolibrary.org/obo/GOCHE_48705</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_25692</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_25692 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52208</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901554</classIRI>
<classLabel>response to paracetamol</classLabel>
<newAxiom>&apos;response to paracetamol&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
<newAxiom>&apos;response to paracetamol&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901555</classIRI>
<classLabel>response to paclitaxel</classLabel>
<newAxiom>&apos;response to paclitaxel&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901556</classIRI>
<classLabel>response to candesartan</classLabel>
<newAxiom>&apos;response to candesartan&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
<newAxiom>&apos;response to candesartan&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901557</classIRI>
<classLabel>response to fenofibrate</classLabel>
<newAxiom>&apos;response to fenofibrate&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
<newAxiom>&apos;response to fenofibrate&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901558</classIRI>
<classLabel>response to metformin</classLabel>
<newAxiom>&apos;response to metformin&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
<newAxiom>&apos;response to metformin&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901559</classIRI>
<classLabel>response to ribavirin</classLabel>
<newAxiom>&apos;response to ribavirin&apos; SubClassOf &apos;response to reverse transcriptase inhibitor&apos;</newAxiom>
<newAxiom>&apos;response to ribavirin&apos; SubClassOf &apos;response to antimetabolite&apos;</newAxiom>
<newAxiom>&apos;response to ribavirin&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901561</classIRI>
<classLabel>response to benomyl</classLabel>
<newAxiom>&apos;response to benomyl&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
<newAxiom>&apos;response to benomyl&apos; SubClassOf &apos;response to fungicide&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901562</classIRI>
<classLabel>response to paraquat</classLabel>
<newAxiom>&apos;response to paraquat&apos; SubClassOf &apos;response to herbicide&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901563</classIRI>
<classLabel>response to camptothecin</classLabel>
<newAxiom>&apos;response to camptothecin&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_25681</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_25681 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_49637</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_49637 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33284</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901499</classIRI>
<classLabel>response to hexane</classLabel>
<newAxiom>&apos;response to hexane&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_49703</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_49703 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35222</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_49703 SubClassOf http://purl.obolibrary.org/obo/GOCHE_27026</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_25705</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_25705 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24852</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_25711</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_25711 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24852</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0043636</classIRI>
<classLabel>bisphenol A catabolic process</classLabel>
<newAxiom>&apos;bisphenol A catabolic process&apos; SubClassOf &apos;hormone catabolic process&apos;</newAxiom>
<newAxiom>&apos;bisphenol A catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0043639</classIRI>
<classLabel>benzoate catabolic process</classLabel>
<newAxiom>&apos;benzoate catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901600</classIRI>
<classLabel>strigolactone metabolic process</classLabel>
<newAxiom>&apos;strigolactone metabolic process&apos; SubClassOf &apos;hormone metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901601</classIRI>
<classLabel>strigolactone biosynthetic process</classLabel>
<newAxiom>&apos;strigolactone biosynthetic process&apos; SubClassOf &apos;hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_60377</classIRI>
<deletedAxiom>http://purl.obolibrary.org/obo/CHEBI_60377 SubClassOf http://purl.obolibrary.org/obo/CHEBI_58043</deletedAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_60377 SubClassOf http://purl.obolibrary.org/obo/CHEBI_138238</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_60377 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_35390</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_35390 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_35391</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_35391 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901695</classIRI>
<classLabel>tyramine biosynthetic process</classLabel>
<newAxiom>&apos;tyramine biosynthetic process&apos; SubClassOf &apos;neurotransmitter biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_59338</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_59338 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901688</classIRI>
<classLabel>pantothenate import</classLabel>
<newAxiom>&apos;pantothenate import&apos; SubClassOf &apos;vitamin transport&apos;</newAxiom>
<newAxiom>&apos;pantothenate import&apos; SubClassOf &apos;cofactor transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_59414</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_59414 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_59414 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24432</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901596</classIRI>
<classLabel>response to reversine</classLabel>
<newAxiom>&apos;response to reversine&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901597</classIRI>
<classLabel>response to carbendazim</classLabel>
<newAxiom>&apos;response to carbendazim&apos; SubClassOf &apos;response to fungicide&apos;</newAxiom>
<newAxiom>&apos;response to carbendazim&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_35418</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_35418 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_35404</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_35404 SubClassOf http://purl.obolibrary.org/obo/GOCHE_51086</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901704</classIRI>
<classLabel>L-glutamine biosynthetic process</classLabel>
<newAxiom>&apos;L-glutamine biosynthetic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901732</classIRI>
<classLabel>quercetin metabolic process</classLabel>
<newAxiom>&apos;quercetin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
<newAxiom>&apos;quercetin metabolic process&apos; SubClassOf &apos;hormone metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901733</classIRI>
<classLabel>quercetin catabolic process</classLabel>
<newAxiom>&apos;quercetin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
<newAxiom>&apos;quercetin catabolic process&apos; SubClassOf &apos;hormone catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901734</classIRI>
<classLabel>quercetin biosynthetic process</classLabel>
<newAxiom>&apos;quercetin biosynthetic process&apos; SubClassOf &apos;hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901748</classIRI>
<classLabel>leukotriene D4 metabolic process</classLabel>
<newAxiom>&apos;leukotriene D4 metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901749</classIRI>
<classLabel>leukotriene D4 catabolic process</classLabel>
<newAxiom>&apos;leukotriene D4 catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901715</classIRI>
<classLabel>regulation of gamma-aminobutyric acid catabolic process</classLabel>
<newAxiom>&apos;regulation of gamma-aminobutyric acid catabolic process&apos; SubClassOf &apos;regulation of neurotransmitter levels&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901728</classIRI>
<classLabel>monensin A metabolic process</classLabel>
<newAxiom>&apos;monensin A metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901729</classIRI>
<classLabel>monensin A catabolic process</classLabel>
<newAxiom>&apos;monensin A catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_35291</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_35291 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901770</classIRI>
<classLabel>daunorubicin catabolic process</classLabel>
<newAxiom>&apos;daunorubicin catabolic process&apos; SubClassOf &apos;detoxification of nitrogen compound&apos;</newAxiom>
<newAxiom>&apos;daunorubicin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901775</classIRI>
<classLabel>mitomycin C metabolic process</classLabel>
<newAxiom>&apos;mitomycin C metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901776</classIRI>
<classLabel>mitomycin C catabolic process</classLabel>
<newAxiom>&apos;mitomycin C catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901784</classIRI>
<classLabel>p-cresol metabolic process</classLabel>
<newAxiom>&apos;p-cresol metabolic process&apos; SubClassOf &apos;toxin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901785</classIRI>
<classLabel>p-cresol catabolic process</classLabel>
<newAxiom>&apos;p-cresol catabolic process&apos; SubClassOf &apos;toxin catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901786</classIRI>
<classLabel>p-cresol biosynthetic process</classLabel>
<newAxiom>&apos;p-cresol biosynthetic process&apos; SubClassOf &apos;toxin biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901754</classIRI>
<classLabel>vitamin D3 catabolic process</classLabel>
<newAxiom>&apos;vitamin D3 catabolic process&apos; SubClassOf &apos;hormone catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901755</classIRI>
<classLabel>vitamin D3 biosynthetic process</classLabel>
<newAxiom>&apos;vitamin D3 biosynthetic process&apos; SubClassOf &apos;hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_59240</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_59240 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24432</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_35280</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_35280 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52211</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901761</classIRI>
<classLabel>oxytetracycline metabolic process</classLabel>
<newAxiom>&apos;oxytetracycline metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901762</classIRI>
<classLabel>oxytetracycline catabolic process</classLabel>
<newAxiom>&apos;oxytetracycline catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_59237</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_59237 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24432</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_35338</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_35338 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35470</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_25961</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_25961 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35703</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_326268</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_326268 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0043400</classIRI>
<classLabel>cortisol secretion</classLabel>
<newAxiom>&apos;cortisol secretion&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_25903</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_25903 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_25905</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_25905 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24621</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0043420</classIRI>
<classLabel>anthranilate metabolic process</classLabel>
<newAxiom>&apos;anthranilate metabolic process&apos; SubClassOf &apos;water-soluble vitamin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0043421</classIRI>
<classLabel>anthranilate catabolic process</classLabel>
<newAxiom>&apos;anthranilate catabolic process&apos; SubClassOf &apos;water-soluble vitamin catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901813</classIRI>
<classLabel>astaxanthin metabolic process</classLabel>
<newAxiom>&apos;astaxanthin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901814</classIRI>
<classLabel>astaxanthin catabolic process</classLabel>
<newAxiom>&apos;astaxanthin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_50398</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_50398 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0043396</classIRI>
<classLabel>corticotropin-releasing hormone secretion</classLabel>
<newAxiom>&apos;corticotropin-releasing hormone secretion&apos; SubClassOf &apos;neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0043397</classIRI>
<classLabel>regulation of corticotropin-releasing hormone secretion</classLabel>
<newAxiom>&apos;regulation of corticotropin-releasing hormone secretion&apos; SubClassOf &apos;regulation of neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_111511</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_111511 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901850</classIRI>
<classLabel>7,8-didemethyl-8-hydroxy-5-deazariboflavin metabolic process</classLabel>
<newAxiom>&apos;7,8-didemethyl-8-hydroxy-5-deazariboflavin metabolic process&apos; SubClassOf &apos;cofactor metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901851</classIRI>
<classLabel>7,8-didemethyl-8-hydroxy-5-deazariboflavin catabolic process</classLabel>
<newAxiom>&apos;7,8-didemethyl-8-hydroxy-5-deazariboflavin catabolic process&apos; SubClassOf &apos;cofactor catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901852</classIRI>
<classLabel>7,8-didemethyl-8-hydroxy-5-deazariboflavin biosynthetic process</classLabel>
<newAxiom>&apos;7,8-didemethyl-8-hydroxy-5-deazariboflavin biosynthetic process&apos; SubClassOf &apos;cofactor biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901867</classIRI>
<classLabel>ecgonine methyl ester metabolic process</classLabel>
<newAxiom>&apos;ecgonine methyl ester metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901868</classIRI>
<classLabel>ecgonine methyl ester catabolic process</classLabel>
<newAxiom>&apos;ecgonine methyl ester catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_64974</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_64974 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901847</classIRI>
<classLabel>nicotinate metabolic process</classLabel>
<newAxiom>&apos;nicotinate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
<newAxiom>&apos;nicotinate metabolic process&apos; SubClassOf &apos;water-soluble vitamin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901848</classIRI>
<classLabel>nicotinate catabolic process</classLabel>
<newAxiom>&apos;nicotinate catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
<newAxiom>&apos;nicotinate catabolic process&apos; SubClassOf &apos;water-soluble vitamin catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901849</classIRI>
<classLabel>nicotinate biosynthetic process</classLabel>
<newAxiom>&apos;nicotinate biosynthetic process&apos; SubClassOf &apos;water-soluble vitamin biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_4672 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35610</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_4629</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_4629 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_4629 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_4629 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35610</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900920</classIRI>
<classLabel>regulation of L-glutamate import</classLabel>
<newAxiom>&apos;regulation of L-glutamate import&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
<newAxiom>&apos;regulation of L-glutamate import&apos; SubClassOf &apos;regulation of neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900921</classIRI>
<classLabel>negative regulation of L-glutamate import</classLabel>
<newAxiom>&apos;negative regulation of L-glutamate import&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
<newAxiom>&apos;negative regulation of L-glutamate import&apos; SubClassOf &apos;negative regulation of neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900922</classIRI>
<classLabel>positive regulation of L-glutamate import</classLabel>
<newAxiom>&apos;positive regulation of L-glutamate import&apos; SubClassOf &apos;positive regulation of neurotransmitter transport&apos;</newAxiom>
<newAxiom>&apos;positive regulation of L-glutamate import&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900923</classIRI>
<classLabel>regulation of glycine import</classLabel>
<newAxiom>&apos;regulation of glycine import&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
<newAxiom>&apos;regulation of glycine import&apos; SubClassOf &apos;regulation of neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900924</classIRI>
<classLabel>negative regulation of glycine import</classLabel>
<newAxiom>&apos;negative regulation of glycine import&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
<newAxiom>&apos;negative regulation of glycine import&apos; SubClassOf &apos;negative regulation of neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900925</classIRI>
<classLabel>positive regulation of glycine import</classLabel>
<newAxiom>&apos;positive regulation of glycine import&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
<newAxiom>&apos;positive regulation of glycine import&apos; SubClassOf &apos;positive regulation of neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900926</classIRI>
<classLabel>regulation of L-threonine import</classLabel>
<newAxiom>&apos;regulation of L-threonine import&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900927</classIRI>
<classLabel>negative regulation of L-threonine import</classLabel>
<newAxiom>&apos;negative regulation of L-threonine import&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900928</classIRI>
<classLabel>positive regulation of L-threonine import</classLabel>
<newAxiom>&apos;positive regulation of L-threonine import&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900929</classIRI>
<classLabel>regulation of L-tyrosine import</classLabel>
<newAxiom>&apos;regulation of L-tyrosine import&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900930</classIRI>
<classLabel>negative regulation of L-tyrosine import</classLabel>
<newAxiom>&apos;negative regulation of L-tyrosine import&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900931</classIRI>
<classLabel>positive regulation of L-tyrosine import</classLabel>
<newAxiom>&apos;positive regulation of L-tyrosine import&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_22720</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_22720 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52210</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_22720 SubClassOf http://purl.obolibrary.org/obo/GOCHE_38632</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_22720 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0045428</classIRI>
<classLabel>regulation of nitric oxide biosynthetic process</classLabel>
<newAxiom>&apos;regulation of nitric oxide biosynthetic process&apos; SubClassOf &apos;regulation of neurotransmitter levels&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0045471</classIRI>
<classLabel>response to ethanol</classLabel>
<newAxiom>&apos;response to ethanol&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
<newAxiom>&apos;response to ethanol&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0045461</classIRI>
<classLabel>sterigmatocystin biosynthetic process</classLabel>
<deletedAxiom>&apos;sterigmatocystin biosynthetic process&apos; SubClassOf &apos;toxin biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;sterigmatocystin biosynthetic process&apos; SubClassOf &apos;mycotoxin biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0045460</classIRI>
<classLabel>sterigmatocystin metabolic process</classLabel>
<deletedAxiom>&apos;sterigmatocystin metabolic process&apos; SubClassOf &apos;toxin metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;sterigmatocystin metabolic process&apos; SubClassOf &apos;mycotoxin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0045490</classIRI>
<classLabel>pectin catabolic process</classLabel>
<newAxiom>&apos;pectin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0045487</classIRI>
<classLabel>gibberellin catabolic process</classLabel>
<newAxiom>&apos;gibberellin catabolic process&apos; SubClassOf &apos;hormone catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0045488</classIRI>
<classLabel>pectin metabolic process</classLabel>
<newAxiom>&apos;pectin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070484</classIRI>
<classLabel>dehydro-D-arabinono-1,4-lactone metabolic process</classLabel>
<newAxiom>&apos;dehydro-D-arabinono-1,4-lactone metabolic process&apos; SubClassOf &apos;cofactor metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070485</classIRI>
<classLabel>dehydro-D-arabinono-1,4-lactone biosynthetic process</classLabel>
<newAxiom>&apos;dehydro-D-arabinono-1,4-lactone biosynthetic process&apos; SubClassOf &apos;cofactor biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_71560</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_71560 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_46645</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_46645 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_22660</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_22660 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_22651</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_22651 SubClassOf http://purl.obolibrary.org/obo/GOCHE_51086</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_22653</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_22653 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_22605</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_22605 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_46904</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_46904 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_46905</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_46905 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_569624</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_569624 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_22927</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_22927 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33284</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_22929</classIRI>
<deletedAxiom>http://purl.obolibrary.org/obo/CHEBI_22929 SubClassOf http://purl.obolibrary.org/obo/CHEBI_22926</deletedAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_22929 SubClassOf http://purl.obolibrary.org/obo/CHEBI_37141</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070301</classIRI>
<classLabel>cellular response to hydrogen peroxide</classLabel>
<newAxiom>&apos;cellular response to hydrogen peroxide&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to hydrogen peroxide&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_22905</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_22905 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_71948</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_71948 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_71949</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_71949 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_71950</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_71950 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_354984</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_354984 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32387</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32387 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_4806</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_4806 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_4806 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_4806 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35610</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32395</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32395 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_4828</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_4828 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_4828 SubClassOf http://purl.obolibrary.org/obo/GOCHE_38161</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32372</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32372 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32373</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32373 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_46998</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_46998 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_46961</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_46961 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0035923</classIRI>
<classLabel>flurbiprofen binding</classLabel>
<newAxiom>&apos;flurbiprofen binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_46957</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_46957 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_22976</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_22976 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0035943</classIRI>
<classLabel>estrone secretion</classLabel>
<deletedAxiom>&apos;estrone secretion&apos; SubClassOf &apos;secretion&apos;</deletedAxiom>
<newAxiom>&apos;estrone secretion&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
<newAxiom>&apos;estrone secretion&apos; SubClassOf &apos;hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_22984</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_22984 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33284</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0035938</classIRI>
<classLabel>estradiol secretion</classLabel>
<deletedAxiom>&apos;estradiol secretion&apos; SubClassOf &apos;secretion&apos;</deletedAxiom>
<newAxiom>&apos;estradiol secretion&apos; SubClassOf &apos;hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0035936</classIRI>
<classLabel>testosterone secretion</classLabel>
<deletedAxiom>&apos;testosterone secretion&apos; SubClassOf &apos;secretion&apos;</deletedAxiom>
<newAxiom>&apos;testosterone secretion&apos; SubClassOf &apos;hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0035941</classIRI>
<classLabel>androstenedione secretion</classLabel>
<deletedAxiom>&apos;androstenedione secretion&apos; SubClassOf &apos;secretion&apos;</deletedAxiom>
<newAxiom>&apos;androstenedione secretion&apos; SubClassOf &apos;hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0035942</classIRI>
<classLabel>dehydroepiandrosterone secretion</classLabel>
<deletedAxiom>&apos;dehydroepiandrosterone secretion&apos; SubClassOf &apos;secretion&apos;</deletedAxiom>
<newAxiom>&apos;dehydroepiandrosterone secretion&apos; SubClassOf &apos;hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_46915</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_46915 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_46914</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_46914 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_46912</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_46912 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070279</classIRI>
<classLabel>vitamin B6 binding</classLabel>
<newAxiom>&apos;vitamin B6 binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070280</classIRI>
<classLabel>pyridoxal binding</classLabel>
<newAxiom>&apos;pyridoxal binding&apos; SubClassOf &apos;cofactor binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070282</classIRI>
<classLabel>pyridoxine binding</classLabel>
<newAxiom>&apos;pyridoxine binding&apos; SubClassOf &apos;cofactor binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_100147</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_100147 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_100147 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070178</classIRI>
<classLabel>D-serine metabolic process</classLabel>
<newAxiom>&apos;D-serine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_46842</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_46842 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_46818</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_46818 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_46828</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_46828 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_246422</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_246422 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_46261</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_46261 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17558 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_4031</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_4031 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_4031 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_4031 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_4031 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0098712</classIRI>
<classLabel>L-glutamate import across plasma membrane</classLabel>
<newAxiom>&apos;L-glutamate import across plasma membrane&apos; SubClassOf &apos;neurotransmitter uptake&apos;</newAxiom>
<newAxiom>&apos;L-glutamate import across plasma membrane&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0098717</classIRI>
<classLabel>pantothenate import across plasma membrane</classLabel>
<newAxiom>&apos;pantothenate import across plasma membrane&apos; SubClassOf &apos;vitamin transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17517</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17517 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17514</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17514 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0050783</classIRI>
<classLabel>cocaine metabolic process</classLabel>
<newAxiom>&apos;cocaine metabolic process&apos; SubClassOf &apos;xenobiotic metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0050784</classIRI>
<classLabel>cocaine catabolic process</classLabel>
<newAxiom>&apos;cocaine catabolic process&apos; SubClassOf &apos;xenobiotic catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0035075</classIRI>
<classLabel>response to ecdysone</classLabel>
<newAxiom>&apos;response to ecdysone&apos; SubClassOf &apos;response to hormone&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0098666</classIRI>
<classLabel>G-protein coupled serotonin receptor complex</classLabel>
<newAxiom>&apos;G-protein coupled serotonin receptor complex&apos; SubClassOf &apos;neurotransmitter receptor complex&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0035094</classIRI>
<classLabel>response to nicotine</classLabel>
<deletedAxiom>&apos;response to nicotine&apos; SubClassOf &apos;response to chemical&apos;</deletedAxiom>
<newAxiom>&apos;response to nicotine&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
<newAxiom>&apos;response to nicotine&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0050696</classIRI>
<classLabel>trichloroethylene catabolic process</classLabel>
<newAxiom>&apos;trichloroethylene catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905135</classIRI>
<classLabel>biotin import across plasma membrane</classLabel>
<newAxiom>&apos;biotin import across plasma membrane&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0001762</classIRI>
<classLabel>beta-alanine transport</classLabel>
<newAxiom>&apos;beta-alanine transport&apos; SubClassOf &apos;neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0001761</classIRI>
<classLabel>beta-alanine transmembrane transporter activity</classLabel>
<newAxiom>&apos;beta-alanine transmembrane transporter activity&apos; SubClassOf &apos;neurotransmitter transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905144</classIRI>
<classLabel>response to acetylcholine</classLabel>
<deletedAxiom>&apos;response to acetylcholine&apos; SubClassOf &apos;response to organic substance&apos;</deletedAxiom>
<newAxiom>&apos;response to acetylcholine&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
<newAxiom>&apos;response to acetylcholine&apos; SubClassOf &apos;response to hormone&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905145</classIRI>
<classLabel>cellular response to acetylcholine</classLabel>
<newAxiom>&apos;cellular response to acetylcholine&apos; SubClassOf &apos;cellular response to hormone stimulus&apos;</newAxiom>
<newAxiom>&apos;cellular response to acetylcholine&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905119</classIRI>
<classLabel>response to haloperidol</classLabel>
<newAxiom>&apos;response to haloperidol&apos; SubClassOf &apos;response to antipsychotic drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905120</classIRI>
<classLabel>cellular response to haloperidol</classLabel>
<newAxiom>&apos;cellular response to haloperidol&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17460</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17460 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17453</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17453 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17489</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17489 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17418</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17418 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17445</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17445 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17447</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17447 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33232</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17447 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17431</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17431 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17437</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17437 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17437 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17401</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17401 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35610</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17401 SubClassOf http://purl.obolibrary.org/obo/GOCHE_38157</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17401 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17401 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33280</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0050665</classIRI>
<classLabel>hydrogen peroxide biosynthetic process</classLabel>
<deletedAxiom>&apos;hydrogen peroxide biosynthetic process&apos; SubClassOf &apos;cellular biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;hydrogen peroxide biosynthetic process&apos; SubClassOf &apos;cofactor biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0050646</classIRI>
<classLabel>5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding</classLabel>
<newAxiom>&apos;5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GOCHE_35457</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/GOCHE_35457 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0001694</classIRI>
<classLabel>histamine biosynthetic process</classLabel>
<newAxiom>&apos;histamine biosynthetic process&apos; SubClassOf &apos;neurotransmitter biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0001692</classIRI>
<classLabel>histamine metabolic process</classLabel>
<newAxiom>&apos;histamine metabolic process&apos; SubClassOf &apos;neurotransmitter metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905218</classIRI>
<classLabel>cellular response to astaxanthin</classLabel>
<newAxiom>&apos;cellular response to astaxanthin&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905217</classIRI>
<classLabel>response to astaxanthin</classLabel>
<newAxiom>&apos;response to astaxanthin&apos; SubClassOf &apos;response to anticoagulant&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905200</classIRI>
<classLabel>gibberellic acid transmembrane transport</classLabel>
<newAxiom>&apos;gibberellic acid transmembrane transport&apos; SubClassOf &apos;hormone transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905206</classIRI>
<classLabel>positive regulation of hydrogen peroxide-induced cell death</classLabel>
<newAxiom>&apos;positive regulation of hydrogen peroxide-induced cell death&apos; SubClassOf &apos;positive regulation of cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17497</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17497 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17497 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_42471</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_42471 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_42471 SubClassOf http://purl.obolibrary.org/obo/GOCHE_48705</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_42471 SubClassOf http://purl.obolibrary.org/obo/GOCHE_50427</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_42471 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905232</classIRI>
<classLabel>cellular response to L-glutamate</classLabel>
<newAxiom>&apos;cellular response to L-glutamate&apos; SubClassOf &apos;cellular response to nutrient&apos;</newAxiom>
<newAxiom>&apos;cellular response to L-glutamate&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905233</classIRI>
<classLabel>response to codeine</classLabel>
<newAxiom>&apos;response to codeine&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
<newAxiom>&apos;response to codeine&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905236</classIRI>
<classLabel>cellular response to quercetin</classLabel>
<newAxiom>&apos;cellular response to quercetin&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to quercetin&apos; SubClassOf &apos;cellular response to hormone stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905237</classIRI>
<classLabel>response to cyclosporin A</classLabel>
<newAxiom>&apos;response to cyclosporin A&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905234</classIRI>
<classLabel>cellular response to codeine</classLabel>
<newAxiom>&apos;cellular response to codeine&apos; SubClassOf &apos;cellular response to xenobiotic stimulus&apos;</newAxiom>
<newAxiom>&apos;cellular response to codeine&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905235</classIRI>
<classLabel>response to quercetin</classLabel>
<newAxiom>&apos;response to quercetin&apos; SubClassOf &apos;response to hormone&apos;</newAxiom>
<newAxiom>&apos;response to quercetin&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905238</classIRI>
<classLabel>cellular response to cyclosporin A</classLabel>
<newAxiom>&apos;cellular response to cyclosporin A&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905243</classIRI>
<classLabel>cellular response to 3,3&apos;,5-triiodo-L-thyronine</classLabel>
<newAxiom>&apos;cellular response to 3,3&apos;,5-triiodo-L-thyronine&apos; SubClassOf &apos;cellular response to thyroid hormone stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905242</classIRI>
<classLabel>response to 3,3&apos;,5-triiodo-L-thyronine</classLabel>
<newAxiom>&apos;response to 3,3&apos;,5-triiodo-L-thyronine&apos; SubClassOf &apos;response to thyroid hormone&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32507</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32507 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32508</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32508 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32510</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32510 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32511</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32511 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_81567</classIRI>
<deletedAxiom>http://purl.obolibrary.org/obo/CHEBI_81567 SubClassOf http://purl.obolibrary.org/obo/CHEBI_50860</deletedAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_81567 SubClassOf http://purl.obolibrary.org/obo/CHEBI_17089</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905307</classIRI>
<classLabel>response to miconazole</classLabel>
<newAxiom>&apos;response to miconazole&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905308</classIRI>
<classLabel>cellular response to miconazole</classLabel>
<newAxiom>&apos;cellular response to miconazole&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32558</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32558 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32556</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32556 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32557</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32557 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32544</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32544 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32552</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32552 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32550</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32550 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32551</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32551 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32512</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32512 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32513</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32513 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32527</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32527 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32526</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32526 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32523</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32523 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32524</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32524 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905429</classIRI>
<classLabel>response to glycine</classLabel>
<newAxiom>&apos;response to glycine&apos; SubClassOf &apos;response to nutrient&apos;</newAxiom>
<newAxiom>&apos;response to glycine&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32486</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32486 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32487</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32487 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905409</classIRI>
<classLabel>positive regulation of creatine transmembrane transporter activity</classLabel>
<newAxiom>&apos;positive regulation of creatine transmembrane transporter activity&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905407</classIRI>
<classLabel>regulation of creatine transmembrane transporter activity</classLabel>
<newAxiom>&apos;regulation of creatine transmembrane transporter activity&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905408</classIRI>
<classLabel>negative regulation of creatine transmembrane transporter activity</classLabel>
<newAxiom>&apos;negative regulation of creatine transmembrane transporter activity&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
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</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905430</classIRI>
<classLabel>cellular response to glycine</classLabel>
<newAxiom>&apos;cellular response to glycine&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to glycine&apos; SubClassOf &apos;cellular response to nutrient&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905431</classIRI>
<classLabel>microcystin transport</classLabel>
<newAxiom>&apos;microcystin transport&apos; SubClassOf &apos;toxin transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32445</classIRI>
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</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32442 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905432</classIRI>
<classLabel>regulation of retrograde trans-synaptic signaling by neuropeptide</classLabel>
<deletedAxiom>&apos;regulation of retrograde trans-synaptic signaling by neuropeptide&apos; SubClassOf &apos;regulation of signaling&apos;</deletedAxiom>
<deletedAxiom>&apos;regulation of retrograde trans-synaptic signaling by neuropeptide&apos; SubClassOf &apos;regulation of cell communication&apos;</deletedAxiom>
<newAxiom>&apos;regulation of retrograde trans-synaptic signaling by neuropeptide&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099177</newAxiom>
</changedClass>
<changedClass>
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</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32440 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32449 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32446 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32446 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52208</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32451 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32450 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
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</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015906</classIRI>
<classLabel>sulfathiazole transport</classLabel>
<newAxiom>&apos;sulfathiazole transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
<newAxiom>&apos;sulfathiazole transport&apos; SubClassOf &apos;xenobiotic transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015903</classIRI>
<classLabel>fluconazole transport</classLabel>
<newAxiom>&apos;fluconazole transport&apos; SubClassOf &apos;xenobiotic transport&apos;</newAxiom>
<newAxiom>&apos;fluconazole transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17120</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17120 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32716</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32716 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32717</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32717 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17126</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17126 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17128</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17128 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17129 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17111 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015942</classIRI>
<classLabel>formate metabolic process</classLabel>
<newAxiom>&apos;formate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32704</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32704 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32702 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_8871</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_8871 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_8871 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52210</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_8871 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35476</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905502</classIRI>
<classLabel>acetyl-CoA binding</classLabel>
<newAxiom>&apos;acetyl-CoA binding&apos; SubClassOf &apos;coenzyme binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905530</classIRI>
<classLabel>negative regulation of uracil import across plasma membrane</classLabel>
<newAxiom>&apos;negative regulation of uracil import across plasma membrane&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905531</classIRI>
<classLabel>positive regulation of uracil import across plasma membrane</classLabel>
<newAxiom>&apos;positive regulation of uracil import across plasma membrane&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905544</classIRI>
<classLabel>L-methionine import across plasma membrane</classLabel>
<newAxiom>&apos;L-methionine import across plasma membrane&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905542</classIRI>
<classLabel>negative regulation of L-arginine import across plasma membrane</classLabel>
<newAxiom>&apos;negative regulation of L-arginine import across plasma membrane&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
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<classLabel>regulation of uracil import across plasma membrane</classLabel>
<newAxiom>&apos;regulation of uracil import across plasma membrane&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17177</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17177 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17170 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17172</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17172 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17196 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33284</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17196 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17192</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17192 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35703</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17192 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24527</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17192 SubClassOf http://purl.obolibrary.org/obo/GOCHE_51086</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17140</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17140 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17148</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17148 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17148 SubClassOf http://purl.obolibrary.org/obo/GOCHE_51086</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17134</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17134 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25512</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17137</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17137 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17138</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17138 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17168</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17168 SubClassOf http://purl.obolibrary.org/obo/CHEBI_138130</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17168 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17164 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32761 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32762</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32762 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32760</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32760 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17158</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17158 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17151</classIRI>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17151 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52211</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17154 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23357</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17154 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17154 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32774</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32774 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32775</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32775 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32773</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32773 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32619</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32619 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32620</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32620 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32624 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32623 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32631</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32631 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32632</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32632 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17000</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17000 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32608</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32608 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32609</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32609 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32604</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32604 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32605</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32605 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015805</classIRI>
<classLabel>S-adenosyl-L-methionine transport</classLabel>
<newAxiom>&apos;S-adenosyl-L-methionine transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015812</classIRI>
<classLabel>gamma-aminobutyric acid transport</classLabel>
<newAxiom>&apos;gamma-aminobutyric acid transport&apos; SubClassOf &apos;neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015816</classIRI>
<classLabel>glycine transport</classLabel>
<newAxiom>&apos;glycine transport&apos; SubClassOf &apos;neurotransmitter transport&apos;</newAxiom>
<newAxiom>&apos;glycine transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015813</classIRI>
<classLabel>L-glutamate transport</classLabel>
<newAxiom>&apos;L-glutamate transport&apos; SubClassOf &apos;neurotransmitter transport&apos;</newAxiom>
<newAxiom>&apos;L-glutamate transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015857</classIRI>
<classLabel>uracil transport</classLabel>
<newAxiom>&apos;uracil transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015867</classIRI>
<classLabel>ATP transport</classLabel>
<newAxiom>&apos;ATP transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015877</classIRI>
<classLabel>biopterin transport</classLabel>
<deletedAxiom>&apos;biopterin transport&apos; SubClassOf &apos;cofactor transport&apos;</deletedAxiom>
<newAxiom>&apos;biopterin transport&apos; SubClassOf &apos;coenzyme transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015878</classIRI>
<classLabel>biotin transport</classLabel>
<deletedAxiom>&apos;biotin transport&apos; SubClassOf &apos;cofactor transport&apos;</deletedAxiom>
<newAxiom>&apos;biotin transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
<newAxiom>&apos;biotin transport&apos; SubClassOf &apos;coenzyme transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015871</classIRI>
<classLabel>choline transport</classLabel>
<newAxiom>&apos;choline transport&apos; SubClassOf &apos;neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015872</classIRI>
<classLabel>dopamine transport</classLabel>
<newAxiom>&apos;dopamine transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015870</classIRI>
<classLabel>acetylcholine transport</classLabel>
<newAxiom>&apos;acetylcholine transport&apos; SubClassOf &apos;hormone transport&apos;</newAxiom>
<newAxiom>&apos;acetylcholine transport&apos; SubClassOf &apos;neurotransmitter transport&apos;</newAxiom>
<newAxiom>&apos;acetylcholine transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015888</classIRI>
<classLabel>thiamine transport</classLabel>
<newAxiom>&apos;thiamine transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_8707</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_8707 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35476</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_8707 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52210</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015889</classIRI>
<classLabel>cobalamin transport</classLabel>
<newAxiom>&apos;cobalamin transport&apos; SubClassOf &apos;cofactor transport&apos;</newAxiom>
<newAxiom>&apos;cobalamin transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015884</classIRI>
<classLabel>folic acid transport</classLabel>
<newAxiom>&apos;folic acid transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015882</classIRI>
<classLabel>L-ascorbic acid transport</classLabel>
<newAxiom>&apos;L-ascorbic acid transport&apos; SubClassOf &apos;coenzyme transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015881</classIRI>
<classLabel>creatine transport</classLabel>
<newAxiom>&apos;creatine transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015891</classIRI>
<classLabel>siderophore transport</classLabel>
<newAxiom>&apos;siderophore transport&apos; SubClassOf &apos;cofactor transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905705</classIRI>
<classLabel>cellular response to paclitaxel</classLabel>
<newAxiom>&apos;cellular response to paclitaxel&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_324935</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_324935 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905625</classIRI>
<classLabel>negative regulation of L-methionine import across plasma membrane</classLabel>
<newAxiom>&apos;negative regulation of L-methionine import across plasma membrane&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905626</classIRI>
<classLabel>positive regulation of L-methionine import across plasma membrane</classLabel>
<newAxiom>&apos;positive regulation of L-methionine import across plasma membrane&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905624</classIRI>
<classLabel>regulation of L-methionine import across plasma membrane</classLabel>
<newAxiom>&apos;regulation of L-methionine import across plasma membrane&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905627</classIRI>
<classLabel>regulation of serotonin biosynthetic process</classLabel>
<newAxiom>&apos;regulation of serotonin biosynthetic process&apos; SubClassOf &apos;regulation of neurotransmitter levels&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GOCHE_59897</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/GOCHE_59897 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905606</classIRI>
<classLabel>regulation of presynapse assembly</classLabel>
<newAxiom>&apos;regulation of presynapse assembly&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099174</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17097</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17097 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52211</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17069</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17069 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17057</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17057 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17053</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17053 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25512</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32682</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32682 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17076</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17076 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17076 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32689</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32689 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17026</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17026 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17026 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17020</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17020 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17029</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17029 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17029 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17012</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17012 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17012 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17012 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17012 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17013</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17013 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17015</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17015 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17015 SubClassOf http://purl.obolibrary.org/obo/GOCHE_27314</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17015 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32637</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32637 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_32638</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_32638 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17032</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17032 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_26271</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_26271 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015724</classIRI>
<classLabel>formate transport</classLabel>
<newAxiom>&apos;formate transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015722</classIRI>
<classLabel>canalicular bile acid transport</classLabel>
<deletedAxiom>&apos;canalicular bile acid transport&apos; SubClassOf &apos;bile acid secretion&apos;</deletedAxiom>
<newAxiom>&apos;canalicular bile acid transport&apos; SubClassOf &apos;acid secretion&apos;</newAxiom>
<newAxiom>&apos;canalicular bile acid transport&apos; SubClassOf &apos;bile acid and bile salt transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015720</classIRI>
<classLabel>allantoin transport</classLabel>
<newAxiom>&apos;allantoin transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015734</classIRI>
<classLabel>taurine transport</classLabel>
<newAxiom>&apos;taurine transport&apos; SubClassOf &apos;organic acid transport&apos;</newAxiom>
<newAxiom>&apos;taurine transport&apos; SubClassOf &apos;xenobiotic transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015730</classIRI>
<classLabel>propanoate transport</classLabel>
<newAxiom>&apos;propanoate transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_41879</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_41879 SubClassOf http://purl.obolibrary.org/obo/GOCHE_51086</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_41879 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35610</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_41879 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35703</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16891</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16891 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16893</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16893 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015744</classIRI>
<classLabel>succinate transport</classLabel>
<newAxiom>&apos;succinate transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015742</classIRI>
<classLabel>alpha-ketoglutarate transport</classLabel>
<newAxiom>&apos;alpha-ketoglutarate transport&apos; SubClassOf &apos;cofactor transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_26214</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_26214 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23357</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_26216</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_26216 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_26216 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33284</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16856</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16856 SubClassOf http://purl.obolibrary.org/obo/GOCHE_51086</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16856 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16856 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33232</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16856 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23357</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16857</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16857 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33284</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16857 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16848</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16848 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23354</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16842</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16842 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16842 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16842 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16862</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16862 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16865</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16865 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25512</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16865 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16933</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16933 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904400</classIRI>
<classLabel>response to Thyroid stimulating hormone</classLabel>
<deletedAxiom>&apos;response to Thyroid stimulating hormone&apos; SubClassOf &apos;response to organic substance&apos;</deletedAxiom>
<newAxiom>&apos;response to Thyroid stimulating hormone&apos; SubClassOf &apos;response to glycoprotein&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904401</classIRI>
<classLabel>cellular response to Thyroid stimulating hormone</classLabel>
<deletedAxiom>&apos;cellular response to Thyroid stimulating hormone&apos; SubClassOf &apos;cellular response to chemical stimulus&apos;</deletedAxiom>
<newAxiom>&apos;cellular response to Thyroid stimulating hormone&apos; SubClassOf &apos;cellular response to glycoprotein&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904402</classIRI>
<classLabel>response to nocodazole</classLabel>
<newAxiom>&apos;response to nocodazole&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904403</classIRI>
<classLabel>cellular response to nocodazole</classLabel>
<newAxiom>&apos;cellular response to nocodazole&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904408</classIRI>
<classLabel>melatonin binding</classLabel>
<newAxiom>&apos;melatonin binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
<newAxiom>&apos;melatonin binding&apos; SubClassOf &apos;hormone binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904406</classIRI>
<classLabel>negative regulation of nitric oxide metabolic process</classLabel>
<newAxiom>&apos;negative regulation of nitric oxide metabolic process&apos; SubClassOf &apos;regulation of neurotransmitter levels&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904407</classIRI>
<classLabel>positive regulation of nitric oxide metabolic process</classLabel>
<newAxiom>&apos;positive regulation of nitric oxide metabolic process&apos; SubClassOf &apos;regulation of neurotransmitter levels&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16918</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16918 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16919</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16919 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16919 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16914</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16914 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16914 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16914 SubClassOf http://purl.obolibrary.org/obo/GOCHE_37848</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16914 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16914 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16953 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
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</changedClass>
<changedClass>
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<classLabel>folic acid import across plasma membrane</classLabel>
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</changedClass>
<changedClass>
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</changedClass>
<changedClass>
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<classLabel>response to 17alpha-ethynylestradiol</classLabel>
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<newAxiom>&apos;response to 17alpha-ethynylestradiol&apos; SubClassOf &apos;response to hormone&apos;</newAxiom>
</changedClass>
<changedClass>
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<classLabel>cellular response to 17alpha-ethynylestradiol</classLabel>
<newAxiom>&apos;cellular response to 17alpha-ethynylestradiol&apos; SubClassOf &apos;cellular response to hormone stimulus&apos;</newAxiom>
<newAxiom>&apos;cellular response to 17alpha-ethynylestradiol&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904473</classIRI>
<classLabel>response to L-dopa</classLabel>
<newAxiom>&apos;response to L-dopa&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
<newAxiom>&apos;response to L-dopa&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
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<classLabel>cellular response to L-dopa</classLabel>
<newAxiom>&apos;cellular response to L-dopa&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to L-dopa&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
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</changedClass>
<changedClass>
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</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_26174 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52214</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_26177 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16768 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16768 SubClassOf http://purl.obolibrary.org/obo/GOCHE_51086</newAxiom>
</changedClass>
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</changedClass>
<changedClass>
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</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16794 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52210</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16794 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35469</newAxiom>
</changedClass>
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</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16783 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16737 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52217</newAxiom>
</changedClass>
<changedClass>
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</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16724 SubClassOf http://purl.obolibrary.org/obo/GOCHE_38867</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904610</classIRI>
<classLabel>response to 3,3&apos;,4,4&apos;,5-pentachlorobiphenyl</classLabel>
<newAxiom>&apos;response to 3,3&apos;,4,4&apos;,5-pentachlorobiphenyl&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16716</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16716 SubClassOf http://purl.obolibrary.org/obo/GOCHE_51086</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16716 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24432</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16716 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33232</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904613</classIRI>
<classLabel>cellular response to 2,3,7,8-tetrachlorodibenzodioxine</classLabel>
<newAxiom>&apos;cellular response to 2,3,7,8-tetrachlorodibenzodioxine&apos; SubClassOf &apos;cellular response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904614</classIRI>
<classLabel>response to biphenyl</classLabel>
<newAxiom>&apos;response to biphenyl&apos; SubClassOf &apos;response to fungicide&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16718</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16718 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904611</classIRI>
<classLabel>cellular response to 3,3&apos;,4,4&apos;,5-pentachlorobiphenyl</classLabel>
<newAxiom>&apos;cellular response to 3,3&apos;,4,4&apos;,5-pentachlorobiphenyl&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904612</classIRI>
<classLabel>response to 2,3,7,8-tetrachlorodibenzodioxine</classLabel>
<newAxiom>&apos;response to 2,3,7,8-tetrachlorodibenzodioxine&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015671</classIRI>
<classLabel>oxygen transport</classLabel>
<newAxiom>&apos;oxygen transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904615</classIRI>
<classLabel>cellular response to biphenyl</classLabel>
<newAxiom>&apos;cellular response to biphenyl&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015670</classIRI>
<classLabel>carbon dioxide transport</classLabel>
<newAxiom>&apos;carbon dioxide transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904619</classIRI>
<classLabel>response to dimethyl sulfoxide</classLabel>
<newAxiom>&apos;response to dimethyl sulfoxide&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16750</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16750 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16755</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16755 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16742</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16742 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16811</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16811 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16813</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16813 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16810</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16810 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23357</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16810 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16836</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16836 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16830</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16830 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16827</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16827 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16828</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16828 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35469</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16828 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33284</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904561</classIRI>
<classLabel>cellular response to diphenidol</classLabel>
<newAxiom>&apos;cellular response to diphenidol&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904560</classIRI>
<classLabel>response to diphenidol</classLabel>
<newAxiom>&apos;response to diphenidol&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_8075</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_8075 SubClassOf http://purl.obolibrary.org/obo/GOCHE_26155</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_8075 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904555</classIRI>
<classLabel>L-proline transmembrane transport</classLabel>
<newAxiom>&apos;L-proline transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904558</classIRI>
<classLabel>response to dextromethorphan</classLabel>
<newAxiom>&apos;response to dextromethorphan&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
<newAxiom>&apos;response to dextromethorphan&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
<newAxiom>&apos;response to dextromethorphan&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904559</classIRI>
<classLabel>cellular response to dextromethorphan</classLabel>
<newAxiom>&apos;cellular response to dextromethorphan&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to dextromethorphan&apos; SubClassOf &apos;cellular response to xenobiotic stimulus&apos;</newAxiom>
<newAxiom>&apos;cellular response to dextromethorphan&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904556</classIRI>
<classLabel>L-tryptophan transmembrane transport</classLabel>
<newAxiom>&apos;L-tryptophan transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_8028</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_8028 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52210</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_8028 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35476</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_26493</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_26493 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_26461</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_26461 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23357</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015546</classIRI>
<classLabel>sulfathiazole transmembrane transporter activity</classLabel>
<newAxiom>&apos;sulfathiazole transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
<newAxiom>&apos;sulfathiazole transmembrane transporter activity&apos; SubClassOf &apos;xenobiotic transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015552</classIRI>
<classLabel>propionate transmembrane transporter activity</classLabel>
<newAxiom>&apos;propionate transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_26404</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_26404 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904643</classIRI>
<classLabel>response to curcumin</classLabel>
<newAxiom>&apos;response to curcumin&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904647</classIRI>
<classLabel>response to rotenone</classLabel>
<newAxiom>&apos;response to rotenone&apos; SubClassOf &apos;response to insecticide&apos;</newAxiom>
<newAxiom>&apos;response to rotenone&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904644</classIRI>
<classLabel>cellular response to curcumin</classLabel>
<newAxiom>&apos;cellular response to curcumin&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904648</classIRI>
<classLabel>cellular response to rotenone</classLabel>
<newAxiom>&apos;cellular response to rotenone&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to rotenone&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904620</classIRI>
<classLabel>cellular response to dimethyl sulfoxide</classLabel>
<deletedAxiom>&apos;cellular response to dimethyl sulfoxide&apos; SubClassOf &apos;cellular response to chemical stimulus&apos;</deletedAxiom>
<newAxiom>&apos;cellular response to dimethyl sulfoxide&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904624</classIRI>
<classLabel>regulation of glycine secretion, neurotransmission</classLabel>
<newAxiom>&apos;regulation of glycine secretion, neurotransmission&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904625</classIRI>
<classLabel>negative regulation of glycine secretion, neurotransmission</classLabel>
<newAxiom>&apos;negative regulation of glycine secretion, neurotransmission&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904628</classIRI>
<classLabel>cellular response to phorbol 13-acetate 12-myristate</classLabel>
<newAxiom>&apos;cellular response to phorbol 13-acetate 12-myristate&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904626</classIRI>
<classLabel>positive regulation of glycine secretion, neurotransmission</classLabel>
<newAxiom>&apos;positive regulation of glycine secretion, neurotransmission&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904627</classIRI>
<classLabel>response to phorbol 13-acetate 12-myristate</classLabel>
<newAxiom>&apos;response to phorbol 13-acetate 12-myristate&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015499</classIRI>
<classLabel>formate transmembrane transporter activity</classLabel>
<newAxiom>&apos;formate transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015498</classIRI>
<classLabel>pantothenate:sodium symporter activity</classLabel>
<newAxiom>&apos;pantothenate:sodium symporter activity&apos; SubClassOf &apos;vitamin transmembrane transporter activity&apos;</newAxiom>
<newAxiom>&apos;pantothenate:sodium symporter activity&apos; SubClassOf &apos;cofactor transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904639</classIRI>
<classLabel>cellular response to resveratrol</classLabel>
<newAxiom>&apos;cellular response to resveratrol&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904638</classIRI>
<classLabel>response to resveratrol</classLabel>
<newAxiom>&apos;response to resveratrol&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904669</classIRI>
<classLabel>ATP export</classLabel>
<newAxiom>&apos;ATP export&apos; SubClassOf &apos;drug export&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_75431</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_75431 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_75431 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35610</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_65932</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_65932 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_65932 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904804</classIRI>
<classLabel>response to latrunculin A</classLabel>
<newAxiom>&apos;response to latrunculin A&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904805</classIRI>
<classLabel>cellular response to latrunculin A</classLabel>
<newAxiom>&apos;cellular response to latrunculin A&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_26345</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_26345 SubClassOf http://purl.obolibrary.org/obo/CHEBI_47783</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_41977</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_41977 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35610</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015411</classIRI>
<classLabel>taurine-transporting ATPase activity</classLabel>
<newAxiom>&apos;taurine-transporting ATPase activity&apos; SubClassOf &apos;organic acid-transporting ATPase activity&apos;</newAxiom>
<newAxiom>&apos;taurine-transporting ATPase activity&apos; SubClassOf &apos;xenobiotic transmembrane transporting ATPase activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16977</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16977 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16973</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16973 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904844</classIRI>
<classLabel>response to L-glutamine</classLabel>
<newAxiom>&apos;response to L-glutamine&apos; SubClassOf &apos;response to nutrient&apos;</newAxiom>
<newAxiom>&apos;response to L-glutamine&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904845</classIRI>
<classLabel>cellular response to L-glutamine</classLabel>
<newAxiom>&apos;cellular response to L-glutamine&apos; SubClassOf &apos;cellular response to nutrient&apos;</newAxiom>
<newAxiom>&apos;cellular response to L-glutamine&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015420</classIRI>
<classLabel>cobalamin-transporting ATPase activity</classLabel>
<newAxiom>&apos;cobalamin-transporting ATPase activity&apos; SubClassOf &apos;cofactor transmembrane transporter activity&apos;</newAxiom>
<newAxiom>&apos;cobalamin-transporting ATPase activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904842</classIRI>
<classLabel>response to nitroglycerin</classLabel>
<newAxiom>&apos;response to nitroglycerin&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904843</classIRI>
<classLabel>cellular response to nitroglycerin</classLabel>
<newAxiom>&apos;cellular response to nitroglycerin&apos; SubClassOf &apos;cellular response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16960</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16960 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16961</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16961 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16962</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16962 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16964</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16964 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16958</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16958 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25512</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16958 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35222</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16958 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16958 SubClassOf http://purl.obolibrary.org/obo/GOCHE_48705</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16990</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16990 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16991</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16991 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16995</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16995 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904826</classIRI>
<classLabel>regulation of hydrogen sulfide biosynthetic process</classLabel>
<newAxiom>&apos;regulation of hydrogen sulfide biosynthetic process&apos; SubClassOf &apos;regulation of secondary metabolite biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904827</classIRI>
<classLabel>negative regulation of hydrogen sulfide biosynthetic process</classLabel>
<newAxiom>&apos;negative regulation of hydrogen sulfide biosynthetic process&apos; SubClassOf &apos;negative regulation of secondary metabolite biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904828</classIRI>
<classLabel>positive regulation of hydrogen sulfide biosynthetic process</classLabel>
<newAxiom>&apos;positive regulation of hydrogen sulfide biosynthetic process&apos; SubClassOf &apos;positive regulation of secondary metabolite biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16988</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16988 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0030975</classIRI>
<classLabel>thiamine binding</classLabel>
<newAxiom>&apos;thiamine binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0030977</classIRI>
<classLabel>taurine binding</classLabel>
<newAxiom>&apos;taurine binding&apos; SubClassOf &apos;organic acid binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015343</classIRI>
<classLabel>siderophore transmembrane transporter activity</classLabel>
<deletedAxiom>&apos;siderophore transmembrane transporter activity&apos; SubClassOf &apos;transmembrane transporter activity&apos;</deletedAxiom>
<newAxiom>&apos;siderophore transmembrane transporter activity&apos; SubClassOf &apos;cofactor transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015375</classIRI>
<classLabel>glycine:sodium symporter activity</classLabel>
<newAxiom>&apos;glycine:sodium symporter activity&apos; SubClassOf &apos;neurotransmitter:sodium symporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_8273</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_8273 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35610</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_8273 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_8273 SubClassOf http://purl.obolibrary.org/obo/GOCHE_50249</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16493</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16493 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16494</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16494 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16480</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16480 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16480 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35523</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16480 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25512</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16480 SubClassOf http://purl.obolibrary.org/obo/GOCHE_51086</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16482</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16482 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16482 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35222</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16452</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16452 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16454</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16454 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16450</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16450 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16457</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16457 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16443</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16443 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52211</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16443 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16449</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16449 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16474</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16474 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16464</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16464 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16467</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16467 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16467 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33284</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16469</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16469 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16410</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16410 SubClassOf http://purl.obolibrary.org/obo/GOCHE_38157</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16410 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16411</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16411 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16411 SubClassOf http://purl.obolibrary.org/obo/GOCHE_22676</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16414</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16414 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16414 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33284</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16436</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16436 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16436 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35471</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16422</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16422 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16422 SubClassOf http://purl.obolibrary.org/obo/GOCHE_50113</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16424</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16424 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015306</classIRI>
<classLabel>sialate:cation symporter activity</classLabel>
<newAxiom>&apos;sialate:cation symporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904947</classIRI>
<classLabel>folic acid import into mitochondrion</classLabel>
<newAxiom>&apos;folic acid import into mitochondrion&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904880</classIRI>
<classLabel>response to hydrogen sulfide</classLabel>
<newAxiom>&apos;response to hydrogen sulfide&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
<newAxiom>&apos;response to hydrogen sulfide&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904881</classIRI>
<classLabel>cellular response to hydrogen sulfide</classLabel>
<newAxiom>&apos;cellular response to hydrogen sulfide&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
<newAxiom>&apos;cellular response to hydrogen sulfide&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015229</classIRI>
<classLabel>L-ascorbic acid transmembrane transporter activity</classLabel>
<newAxiom>&apos;L-ascorbic acid transmembrane transporter activity&apos; SubClassOf &apos;coenzyme transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015224</classIRI>
<classLabel>biopterin transmembrane transporter activity</classLabel>
<deletedAxiom>&apos;biopterin transmembrane transporter activity&apos; SubClassOf &apos;cofactor transmembrane transporter activity&apos;</deletedAxiom>
<newAxiom>&apos;biopterin transmembrane transporter activity&apos; SubClassOf &apos;coenzyme transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015225</classIRI>
<classLabel>biotin transmembrane transporter activity</classLabel>
<deletedAxiom>&apos;biotin transmembrane transporter activity&apos; SubClassOf &apos;cofactor transmembrane transporter activity&apos;</deletedAxiom>
<newAxiom>&apos;biotin transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
<newAxiom>&apos;biotin transmembrane transporter activity&apos; SubClassOf &apos;coenzyme transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015222</classIRI>
<classLabel>serotonin transmembrane transporter activity</classLabel>
<newAxiom>&apos;serotonin transmembrane transporter activity&apos; SubClassOf &apos;neurotransmitter transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015220</classIRI>
<classLabel>choline transmembrane transporter activity</classLabel>
<newAxiom>&apos;choline transmembrane transporter activity&apos; SubClassOf &apos;neurotransmitter transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015233</classIRI>
<classLabel>pantothenate transmembrane transporter activity</classLabel>
<newAxiom>&apos;pantothenate transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015234</classIRI>
<classLabel>thiamine transmembrane transporter activity</classLabel>
<newAxiom>&apos;thiamine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015244</classIRI>
<classLabel>fluconazole transmembrane transporter activity</classLabel>
<newAxiom>&apos;fluconazole transmembrane transporter activity&apos; SubClassOf &apos;xenobiotic transmembrane transporter activity&apos;</newAxiom>
<newAxiom>&apos;fluconazole transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16536 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16537</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16537 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16526</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16526 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52211</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16526 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52210</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16526 SubClassOf http://purl.obolibrary.org/obo/GOCHE_51086</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16526 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16526 SubClassOf http://purl.obolibrary.org/obo/GOCHE_38867</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16526 SubClassOf http://purl.obolibrary.org/obo/CHEBI_138675</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16521</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16521 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16522</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16522 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16523</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16523 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52210</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16523 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16551</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16551 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16556</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16556 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_16510</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_16510 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005542</classIRI>
<classLabel>folic acid binding</classLabel>
<newAxiom>&apos;folic acid binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0030573</classIRI>
<classLabel>bile acid catabolic process</classLabel>
<deletedAxiom>&apos;bile acid catabolic process&apos; SubClassOf &apos;organic hydroxy compound catabolic process&apos;</deletedAxiom>
<deletedAxiom>&apos;bile acid catabolic process&apos; SubClassOf &apos;steroid catabolic process&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_36464</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_36464 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_61402</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_61402 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_61404</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_61404 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005524</classIRI>
<classLabel>ATP binding</classLabel>
<newAxiom>&apos;ATP binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0030419</classIRI>
<classLabel>nicotianamine catabolic process</classLabel>
<newAxiom>&apos;nicotianamine catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0030417</classIRI>
<classLabel>nicotianamine metabolic process</classLabel>
<newAxiom>&apos;nicotianamine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900065</classIRI>
<classLabel>regulation of ethanol catabolic process</classLabel>
<deletedAxiom>&apos;regulation of ethanol catabolic process&apos; SubClassOf &apos;regulation of catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;regulation of ethanol catabolic process&apos; SubClassOf &apos;regulation of cellular catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900066</classIRI>
<classLabel>positive regulation of ethanol catabolic process</classLabel>
<deletedAxiom>&apos;positive regulation of ethanol catabolic process&apos; SubClassOf &apos;positive regulation of catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;positive regulation of ethanol catabolic process&apos; SubClassOf &apos;positive regulation of cellular catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_61382</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_61382 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_61345</classIRI>
<deletedAxiom>http://purl.obolibrary.org/obo/CHEBI_61345 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24028</deletedAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_61345 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_61345 SubClassOf http://purl.obolibrary.org/obo/GOCHE_26672</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_61346</classIRI>
<deletedAxiom>http://purl.obolibrary.org/obo/CHEBI_61346 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24028</deletedAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_61346 SubClassOf http://purl.obolibrary.org/obo/GOCHE_26672</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_61338</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_61338 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23357</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_61338 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_61338 SubClassOf http://purl.obolibrary.org/obo/GOCHE_51086</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_36420</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_36420 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24432</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005302</classIRI>
<classLabel>L-tyrosine transmembrane transporter activity</classLabel>
<newAxiom>&apos;L-tyrosine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005304</classIRI>
<classLabel>L-valine transmembrane transporter activity</classLabel>
<newAxiom>&apos;L-valine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005307</classIRI>
<classLabel>choline:sodium symporter activity</classLabel>
<deletedAxiom>&apos;choline:sodium symporter activity&apos; SubClassOf &apos;solute:sodium symporter activity&apos;</deletedAxiom>
<deletedAxiom>&apos;choline:sodium symporter activity&apos; SubClassOf &apos;imports&apos; some http://purl.obolibrary.org/obo/CHEBI_29101</deletedAxiom>
<newAxiom>&apos;choline:sodium symporter activity&apos; SubClassOf &apos;neurotransmitter:sodium symporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005308</classIRI>
<classLabel>creatine transmembrane transporter activity</classLabel>
<newAxiom>&apos;creatine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_36432</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_36432 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005313</classIRI>
<classLabel>L-glutamate transmembrane transporter activity</classLabel>
<newAxiom>&apos;L-glutamate transmembrane transporter activity&apos; SubClassOf &apos;neurotransmitter transporter activity&apos;</newAxiom>
<newAxiom>&apos;L-glutamate transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005329</classIRI>
<classLabel>dopamine transmembrane transporter activity</classLabel>
<newAxiom>&apos;dopamine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005332</classIRI>
<classLabel>gamma-aminobutyric acid:sodium symporter activity</classLabel>
<newAxiom>&apos;gamma-aminobutyric acid:sodium symporter activity&apos; SubClassOf &apos;neurotransmitter:sodium symporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005347</classIRI>
<classLabel>ATP transmembrane transporter activity</classLabel>
<newAxiom>&apos;ATP transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005368</classIRI>
<classLabel>taurine transmembrane transporter activity</classLabel>
<newAxiom>&apos;taurine transmembrane transporter activity&apos; SubClassOf &apos;organic acid transmembrane transporter activity&apos;</newAxiom>
<newAxiom>&apos;taurine transmembrane transporter activity&apos; SubClassOf &apos;xenobiotic transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_46081</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_46081 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_46081 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35703</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900333</classIRI>
<classLabel>regulation of methane biosynthetic process from 3-(methylthio)propionic acid</classLabel>
<newAxiom>&apos;regulation of methane biosynthetic process from 3-(methylthio)propionic acid&apos; SubClassOf &apos;regulation of secondary metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900336</classIRI>
<classLabel>regulation of methane biosynthetic process from carbon monoxide</classLabel>
<newAxiom>&apos;regulation of methane biosynthetic process from carbon monoxide&apos; SubClassOf &apos;regulation of neurotransmitter levels&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_46053</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_46053 SubClassOf http://purl.obolibrary.org/obo/GOCHE_51086</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_46024</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_46024 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_36786</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_36786 SubClassOf http://purl.obolibrary.org/obo/CHEBI_33836</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019825</classIRI>
<classLabel>oxygen binding</classLabel>
<deletedAxiom>&apos;oxygen binding&apos; SubClassOf &apos;binding&apos;</deletedAxiom>
<newAxiom>&apos;oxygen binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_22152</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_22152 SubClassOf http://purl.obolibrary.org/obo/GOCHE_48705</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019852</classIRI>
<classLabel>L-ascorbic acid metabolic process</classLabel>
<newAxiom>&apos;L-ascorbic acid metabolic process&apos; SubClassOf &apos;coenzyme metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019853</classIRI>
<classLabel>L-ascorbic acid biosynthetic process</classLabel>
<newAxiom>&apos;L-ascorbic acid biosynthetic process&apos; SubClassOf &apos;coenzyme biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_36773</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_36773 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019854</classIRI>
<classLabel>L-ascorbic acid catabolic process</classLabel>
<newAxiom>&apos;L-ascorbic acid catabolic process&apos; SubClassOf &apos;coenzyme catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019860</classIRI>
<classLabel>uracil metabolic process</classLabel>
<newAxiom>&apos;uracil metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_36740</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_36740 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_12777</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_12777 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_12777 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24020</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_36756</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_36756 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0030209</classIRI>
<classLabel>dermatan sulfate catabolic process</classLabel>
<newAxiom>&apos;dermatan sulfate catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0030205</classIRI>
<classLabel>dermatan sulfate metabolic process</classLabel>
<newAxiom>&apos;dermatan sulfate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005277</classIRI>
<classLabel>acetylcholine transmembrane transporter activity</classLabel>
<newAxiom>&apos;acetylcholine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005278</classIRI>
<classLabel>acetylcholine:proton antiporter activity</classLabel>
<deletedAxiom>&apos;acetylcholine:proton antiporter activity&apos; SubClassOf &apos;exports&apos; some http://purl.obolibrary.org/obo/CHEBI_24636</deletedAxiom>
<deletedAxiom>&apos;acetylcholine:proton antiporter activity&apos; SubClassOf &apos;solute:proton antiporter activity&apos;</deletedAxiom>
<newAxiom>&apos;acetylcholine:proton antiporter activity&apos; SubClassOf &apos;drug:proton antiporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005290</classIRI>
<classLabel>L-histidine transmembrane transporter activity</classLabel>
<newAxiom>&apos;L-histidine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0030184</classIRI>
<classLabel>nitric oxide transmembrane transporter activity</classLabel>
<newAxiom>&apos;nitric oxide transmembrane transporter activity&apos; SubClassOf &apos;neurotransmitter transporter activity&apos;</newAxiom>
<newAxiom>&apos;nitric oxide transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0030185</classIRI>
<classLabel>nitric oxide transport</classLabel>
<newAxiom>&apos;nitric oxide transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
<newAxiom>&apos;nitric oxide transport&apos; SubClassOf &apos;neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0030186</classIRI>
<classLabel>melatonin metabolic process</classLabel>
<newAxiom>&apos;melatonin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0030170</classIRI>
<classLabel>pyridoxal phosphate binding</classLabel>
<deletedAxiom>&apos;pyridoxal phosphate binding&apos; SubClassOf &apos;cofactor binding&apos;</deletedAxiom>
<newAxiom>&apos;pyridoxal phosphate binding&apos; SubClassOf &apos;coenzyme binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_61509</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_61509 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_36655</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_36655 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0030152</classIRI>
<classLabel>bacteriocin biosynthetic process</classLabel>
<deletedAxiom>&apos;bacteriocin biosynthetic process&apos; SubClassOf &apos;toxin biosynthetic process&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_61057</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_61057 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_61057 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24432</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_61049</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_61049 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_61049 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_36090</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_36090 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_36062</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_36062 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35610</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_36062 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_36062 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900539</classIRI>
<classLabel>fumonisin metabolic process</classLabel>
<deletedAxiom>&apos;fumonisin metabolic process&apos; SubClassOf &apos;secondary metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;fumonisin metabolic process&apos; SubClassOf &apos;mycotoxin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_36021</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_36021 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_36033</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_36033 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900573</classIRI>
<classLabel>emodin metabolic process</classLabel>
<newAxiom>&apos;emodin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900574</classIRI>
<classLabel>emodin catabolic process</classLabel>
<newAxiom>&apos;emodin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900540</classIRI>
<classLabel>fumonisin catabolic process</classLabel>
<deletedAxiom>&apos;fumonisin catabolic process&apos; SubClassOf &apos;secondary metabolite catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;fumonisin catabolic process&apos; SubClassOf &apos;mycotoxin catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900541</classIRI>
<classLabel>fumonisin biosynthetic process</classLabel>
<deletedAxiom>&apos;fumonisin biosynthetic process&apos; SubClassOf &apos;secondary metabolite biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;fumonisin biosynthetic process&apos; SubClassOf &apos;mycotoxin biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900552</classIRI>
<classLabel>asperfuranone metabolic process</classLabel>
<newAxiom>&apos;asperfuranone metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900553</classIRI>
<classLabel>asperfuranone catabolic process</classLabel>
<newAxiom>&apos;asperfuranone catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900588</classIRI>
<classLabel>violaceol I metabolic process</classLabel>
<deletedAxiom>&apos;violaceol I metabolic process&apos; SubClassOf &apos;secondary metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;violaceol I metabolic process&apos; SubClassOf &apos;mycotoxin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900589</classIRI>
<classLabel>violaceol I catabolic process</classLabel>
<deletedAxiom>&apos;violaceol I catabolic process&apos; SubClassOf &apos;secondary metabolite catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;violaceol I catabolic process&apos; SubClassOf &apos;mycotoxin catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900590</classIRI>
<classLabel>violaceol I biosynthetic process</classLabel>
<deletedAxiom>&apos;violaceol I biosynthetic process&apos; SubClassOf &apos;secondary metabolite biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;violaceol I biosynthetic process&apos; SubClassOf &apos;mycotoxin biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900591</classIRI>
<classLabel>violaceol II metabolic process</classLabel>
<deletedAxiom>&apos;violaceol II metabolic process&apos; SubClassOf &apos;secondary metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;violaceol II metabolic process&apos; SubClassOf &apos;mycotoxin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900592</classIRI>
<classLabel>violaceol II catabolic process</classLabel>
<deletedAxiom>&apos;violaceol II catabolic process&apos; SubClassOf &apos;secondary metabolite catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;violaceol II catabolic process&apos; SubClassOf &apos;mycotoxin catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900593</classIRI>
<classLabel>violaceol II biosynthetic process</classLabel>
<deletedAxiom>&apos;violaceol II biosynthetic process&apos; SubClassOf &apos;secondary metabolite biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;violaceol II biosynthetic process&apos; SubClassOf &apos;mycotoxin biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_3766</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_3766 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35703</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_3766 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_3766 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35476</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019608</classIRI>
<classLabel>nicotine catabolic process</classLabel>
<deletedAxiom>&apos;nicotine catabolic process&apos; SubClassOf &apos;catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;nicotine catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019619</classIRI>
<classLabel>3,4-dihydroxybenzoate catabolic process</classLabel>
<newAxiom>&apos;3,4-dihydroxybenzoate catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_26708</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_26708 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_134256</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_134256 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_134269</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_134269 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33280</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0044610</classIRI>
<classLabel>FMN transmembrane transporter activity</classLabel>
<newAxiom>&apos;FMN transmembrane transporter activity&apos; SubClassOf &apos;coenzyme transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019695</classIRI>
<classLabel>choline metabolic process</classLabel>
<newAxiom>&apos;choline metabolic process&apos; SubClassOf &apos;neurotransmitter metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_61085</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_61085 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0044597</classIRI>
<classLabel>daunorubicin metabolic process</classLabel>
<newAxiom>&apos;daunorubicin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0044589</classIRI>
<classLabel>pectin binding</classLabel>
<newAxiom>&apos;pectin binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_26546</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_26546 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_26536</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_26536 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_3638</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_3638 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52206</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_3638 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35222</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_3638 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_3638 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_26605</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_26605 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019510</classIRI>
<classLabel>S-adenosylhomocysteine catabolic process</classLabel>
<newAxiom>&apos;S-adenosylhomocysteine catabolic process&apos; SubClassOf &apos;cofactor catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019517</classIRI>
<classLabel>L-threonine catabolic process to D-lactate</classLabel>
<newAxiom>&apos;L-threonine catabolic process to D-lactate&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019518</classIRI>
<classLabel>L-threonine catabolic process to glycine</classLabel>
<newAxiom>&apos;L-threonine catabolic process to glycine&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019529</classIRI>
<classLabel>taurine catabolic process</classLabel>
<newAxiom>&apos;taurine catabolic process&apos; SubClassOf &apos;organic acid catabolic process&apos;</newAxiom>
<newAxiom>&apos;taurine catabolic process&apos; SubClassOf &apos;xenobiotic catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019530</classIRI>
<classLabel>taurine metabolic process</classLabel>
<newAxiom>&apos;taurine metabolic process&apos; SubClassOf &apos;xenobiotic metabolic process&apos;</newAxiom>
<newAxiom>&apos;taurine metabolic process&apos; SubClassOf &apos;organic acid metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019537</classIRI>
<classLabel>vibriobactin biosynthetic process</classLabel>
<newAxiom>&apos;vibriobactin biosynthetic process&apos; SubClassOf &apos;cofactor biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019541</classIRI>
<classLabel>propionate metabolic process</classLabel>
<newAxiom>&apos;propionate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019543</classIRI>
<classLabel>propionate catabolic process</classLabel>
<newAxiom>&apos;propionate catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_75525</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_75525 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900770</classIRI>
<classLabel>fumitremorgin B metabolic process</classLabel>
<deletedAxiom>&apos;fumitremorgin B metabolic process&apos; SubClassOf &apos;secondary metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;fumitremorgin B metabolic process&apos; SubClassOf &apos;mycotoxin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900771</classIRI>
<classLabel>fumitremorgin B catabolic process</classLabel>
<deletedAxiom>&apos;fumitremorgin B catabolic process&apos; SubClassOf &apos;secondary metabolite catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;fumitremorgin B catabolic process&apos; SubClassOf &apos;detoxification of nitrogen compound&apos;</newAxiom>
<newAxiom>&apos;fumitremorgin B catabolic process&apos; SubClassOf &apos;mycotoxin catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900772</classIRI>
<classLabel>fumitremorgin B biosynthetic process</classLabel>
<deletedAxiom>&apos;fumitremorgin B biosynthetic process&apos; SubClassOf &apos;secondary metabolite biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;fumitremorgin B biosynthetic process&apos; SubClassOf &apos;mycotoxin biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_36281</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_36281 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_36281 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900749</classIRI>
<classLabel>(R)-carnitine transport</classLabel>
<newAxiom>&apos;(R)-carnitine transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
<newAxiom>&apos;(R)-carnitine transport&apos; SubClassOf &apos;vitamin transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_36264</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_36264 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_36242</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_36242 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900794</classIRI>
<classLabel>terrequinone A metabolic process</classLabel>
<newAxiom>&apos;terrequinone A metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900795</classIRI>
<classLabel>terrequinone A catabolic process</classLabel>
<newAxiom>&apos;terrequinone A catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900797</classIRI>
<classLabel>cordyol C metabolic process</classLabel>
<newAxiom>&apos;cordyol C metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900798</classIRI>
<classLabel>cordyol C catabolic process</classLabel>
<newAxiom>&apos;cordyol C catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_51860</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_51860 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52210</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_51860 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_36234</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_36234 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_36235</classIRI>
<deletedAxiom>http://purl.obolibrary.org/obo/CHEBI_36235 SubClassOf http://purl.obolibrary.org/obo/CHEBI_36078</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_36208</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_36208 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_26895</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_26895 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_134045</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_134045 SubClassOf http://purl.obolibrary.org/obo/GOCHE_51086</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_26948</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_26948 SubClassOf http://purl.obolibrary.org/obo/GOCHE_27314</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_26948 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_3962</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_3962 SubClassOf http://purl.obolibrary.org/obo/GOCHE_38157</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_3962 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52211</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_3962 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35610</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_3962 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_3962 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52208</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_3962 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019415</classIRI>
<classLabel>acetate biosynthetic process from carbon monoxide</classLabel>
<newAxiom>&apos;acetate biosynthetic process from carbon monoxide&apos; SubClassOf &apos;neurotransmitter metabolic process&apos;</newAxiom>
<newAxiom>&apos;acetate biosynthetic process from carbon monoxide&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019429</classIRI>
<classLabel>fluorene catabolic process</classLabel>
<newAxiom>&apos;fluorene catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_26911</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_26911 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33232</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_26911 SubClassOf http://purl.obolibrary.org/obo/GOCHE_51086</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019477</classIRI>
<classLabel>L-lysine catabolic process</classLabel>
<newAxiom>&apos;L-lysine catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019482</classIRI>
<classLabel>beta-alanine metabolic process</classLabel>
<newAxiom>&apos;beta-alanine metabolic process&apos; SubClassOf &apos;neurotransmitter metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019483</classIRI>
<classLabel>beta-alanine biosynthetic process</classLabel>
<newAxiom>&apos;beta-alanine biosynthetic process&apos; SubClassOf &apos;neurotransmitter biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019484</classIRI>
<classLabel>beta-alanine catabolic process</classLabel>
<newAxiom>&apos;beta-alanine catabolic process&apos; SubClassOf &apos;neurotransmitter catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019386</classIRI>
<classLabel>methanogenesis, from carbon dioxide</classLabel>
<newAxiom>&apos;methanogenesis, from carbon dioxide&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019382</classIRI>
<classLabel>carbon tetrachloride catabolic process</classLabel>
<deletedAxiom>&apos;carbon tetrachloride catabolic process&apos; SubClassOf &apos;chlorinated hydrocarbon catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;carbon tetrachloride catabolic process&apos; SubClassOf &apos;organic substance catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019396</classIRI>
<classLabel>gallate catabolic process</classLabel>
<newAxiom>&apos;gallate catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900817</classIRI>
<classLabel>ochratoxin A catabolic process</classLabel>
<deletedAxiom>&apos;ochratoxin A catabolic process&apos; SubClassOf &apos;secondary metabolite catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;ochratoxin A catabolic process&apos; SubClassOf &apos;mycotoxin catabolic process&apos;</newAxiom>
<newAxiom>&apos;ochratoxin A catabolic process&apos; SubClassOf &apos;detoxification of nitrogen compound&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900818</classIRI>
<classLabel>ochratoxin A biosynthetic process</classLabel>
<deletedAxiom>&apos;ochratoxin A biosynthetic process&apos; SubClassOf &apos;secondary metabolite biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;ochratoxin A biosynthetic process&apos; SubClassOf &apos;mycotoxin biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900866</classIRI>
<classLabel>glycolate transport</classLabel>
<newAxiom>&apos;glycolate transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900874</classIRI>
<classLabel>heptadec-1-ene metabolic process</classLabel>
<newAxiom>&apos;heptadec-1-ene metabolic process&apos; SubClassOf &apos;pheromone metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900875</classIRI>
<classLabel>heptadec-1-ene biosynthetic process</classLabel>
<newAxiom>&apos;heptadec-1-ene biosynthetic process&apos; SubClassOf &apos;pheromone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_26759</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_26759 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25442</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_26764</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_26764 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24621</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_3892</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_3892 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52217</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_26848</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_26848 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_26831</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_26831 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24527</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_26831 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_26833</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_26833 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33284</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010956</classIRI>
<classLabel>negative regulation of calcidiol 1-monooxygenase activity</classLabel>
<newAxiom>&apos;negative regulation of calcidiol 1-monooxygenase activity&apos; SubClassOf &apos;negative regulation of hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010963</classIRI>
<classLabel>regulation of L-arginine import</classLabel>
<newAxiom>&apos;regulation of L-arginine import&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019339</classIRI>
<classLabel>parathion catabolic process</classLabel>
<newAxiom>&apos;parathion catabolic process&apos; SubClassOf &apos;insecticide catabolic process&apos;</newAxiom>
<newAxiom>&apos;parathion catabolic process&apos; SubClassOf &apos;detoxification of nitrogen compound&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900816</classIRI>
<classLabel>ochratoxin A metabolic process</classLabel>
<deletedAxiom>&apos;ochratoxin A metabolic process&apos; SubClassOf &apos;secondary metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;ochratoxin A metabolic process&apos; SubClassOf &apos;mycotoxin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_61197</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_61197 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52208</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_61197 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032238</classIRI>
<classLabel>adenosine transport</classLabel>
<newAxiom>&apos;adenosine transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046874</classIRI>
<classLabel>quinolinate metabolic process</classLabel>
<newAxiom>&apos;quinolinate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046898</classIRI>
<classLabel>response to cycloheximide</classLabel>
<newAxiom>&apos;response to cycloheximide&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
<newAxiom>&apos;response to cycloheximide&apos; SubClassOf &apos;response to fungicide&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032249</classIRI>
<classLabel>regulation of adenosine transport</classLabel>
<newAxiom>&apos;regulation of adenosine transport&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032251</classIRI>
<classLabel>positive regulation of adenosine transport</classLabel>
<newAxiom>&apos;positive regulation of adenosine transport&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032250</classIRI>
<classLabel>negative regulation of adenosine transport</classLabel>
<newAxiom>&apos;negative regulation of adenosine transport&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071886</classIRI>
<classLabel>1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding</classLabel>
<newAxiom>&apos;1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_3392</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_3392 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_3392 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52210</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_3392 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_3375</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_3375 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_57392</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_57392 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_57384</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_57384 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_3349</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_3349 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_3349 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_3347</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_3347 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52210</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_3347 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35703</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_3347 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_57371</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_57371 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_57484</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_57484 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_57472</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_57472 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0140009</classIRI>
<classLabel>L-aspartate import across plasma membrane</classLabel>
<newAxiom>&apos;L-aspartate import across plasma membrane&apos; SubClassOf &apos;neurotransmitter uptake&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_57464</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_57464 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_57463</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_57463 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_57461</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_57461 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_3306</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_3306 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_3306 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_57454</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_57454 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_57451</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_57451 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_57450</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_57450 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_57445</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_57445 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_57443</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_57443 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_57403</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_57403 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_33404</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_33404 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032217</classIRI>
<classLabel>riboflavin transmembrane transporter activity</classLabel>
<newAxiom>&apos;riboflavin transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032218</classIRI>
<classLabel>riboflavin transport</classLabel>
<newAxiom>&apos;riboflavin transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071731</classIRI>
<classLabel>response to nitric oxide</classLabel>
<newAxiom>&apos;response to nitric oxide&apos; SubClassOf &apos;response to bronchodilator&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071732</classIRI>
<classLabel>cellular response to nitric oxide</classLabel>
<newAxiom>&apos;cellular response to nitric oxide&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_57299</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_57299 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_57292</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_57292 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_57288</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_57288 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_57287</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_57287 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_57277</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_57277 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_57345</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_57345 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_57344</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_57344 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_57336</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_57336 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_57326</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_57326 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_57307</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_57307 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_57308</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_57308 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_33309</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_33309 SubClassOf http://purl.obolibrary.org/obo/CHEBI_138675</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_23965</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_23965 SubClassOf http://purl.obolibrary.org/obo/GOCHE_50114</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_23965 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046713</classIRI>
<classLabel>borate transport</classLabel>
<newAxiom>&apos;borate transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046715</classIRI>
<classLabel>active borate transmembrane transporter activity</classLabel>
<newAxiom>&apos;active borate transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046714</classIRI>
<classLabel>borate binding</classLabel>
<newAxiom>&apos;borate binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_23955</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_23955 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046657</classIRI>
<classLabel>folic acid catabolic process</classLabel>
<newAxiom>&apos;folic acid catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046655</classIRI>
<classLabel>folic acid metabolic process</classLabel>
<newAxiom>&apos;folic acid metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046680</classIRI>
<classLabel>response to DDT</classLabel>
<newAxiom>&apos;response to DDT&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046679</classIRI>
<classLabel>response to streptomycin</classLabel>
<newAxiom>&apos;response to streptomycin&apos; SubClassOf &apos;response to fungicide&apos;</newAxiom>
<newAxiom>&apos;response to streptomycin&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046677</classIRI>
<classLabel>response to antibiotic</classLabel>
<deletedAxiom>&apos;response to antibiotic&apos; SubClassOf &apos;response to chemical&apos;</deletedAxiom>
<newAxiom>&apos;response to antibiotic&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032052</classIRI>
<classLabel>bile acid binding</classLabel>
<deletedAxiom>&apos;bile acid binding&apos; SubClassOf &apos;steroid binding&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071681</classIRI>
<classLabel>cellular response to indole-3-methanol</classLabel>
<newAxiom>&apos;cellular response to indole-3-methanol&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071680</classIRI>
<classLabel>response to indole-3-methanol</classLabel>
<newAxiom>&apos;response to indole-3-methanol&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_67040</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_67040 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
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</changedClass>
<changedClass>
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<classLabel>L-lysine metabolic process</classLabel>
<newAxiom>&apos;L-lysine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
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<classLabel>aerobactin metabolic process</classLabel>
<newAxiom>&apos;aerobactin metabolic process&apos; SubClassOf &apos;siderophore metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
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<classLabel>cellular response to cycloheximide</classLabel>
<newAxiom>&apos;cellular response to cycloheximide&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
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</changedClass>
<changedClass>
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<classLabel>platelet activating factor metabolic process</classLabel>
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</changedClass>
<changedClass>
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</changedClass>
<changedClass>
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<changedClass>
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</changedClass>
<changedClass>
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</changedClass>
<changedClass>
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</changedClass>
<changedClass>
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</changedClass>
<changedClass>
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<newAxiom>&apos;cellular response to amphetamine&apos; SubClassOf &apos;cellular response to xenobiotic stimulus&apos;</newAxiom>
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</changedClass>
<changedClass>
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</changedClass>
<changedClass>
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<classLabel>cellular response to ozone</classLabel>
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</changedClass>
<changedClass>
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<classLabel>cellular response to cortisol stimulus</classLabel>
<newAxiom>&apos;cellular response to cortisol stimulus&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071390</classIRI>
<classLabel>cellular response to ecdysone</classLabel>
<newAxiom>&apos;cellular response to ecdysone&apos; SubClassOf &apos;cellular response to hormone stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071393</classIRI>
<classLabel>cellular response to progesterone stimulus</classLabel>
<newAxiom>&apos;cellular response to progesterone stimulus&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071392</classIRI>
<classLabel>cellular response to estradiol stimulus</classLabel>
<newAxiom>&apos;cellular response to estradiol stimulus&apos; SubClassOf &apos;cellular response to hormone stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071394</classIRI>
<classLabel>cellular response to testosterone stimulus</classLabel>
<newAxiom>&apos;cellular response to testosterone stimulus&apos; SubClassOf &apos;cellular response to hormone stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071382</classIRI>
<classLabel>cellular response to prostaglandin I stimulus</classLabel>
<newAxiom>&apos;cellular response to prostaglandin I stimulus&apos; SubClassOf &apos;cellular response to organic cyclic compound&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_23671</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_23671 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_23673</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_23673 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_72564</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_72564 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35610</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_72564 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24432</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_23681</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_23681 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046300</classIRI>
<classLabel>2,4-dichlorophenoxyacetic acid catabolic process</classLabel>
<newAxiom>&apos;2,4-dichlorophenoxyacetic acid catabolic process&apos; SubClassOf &apos;xenobiotic catabolic process&apos;</newAxiom>
<newAxiom>&apos;2,4-dichlorophenoxyacetic acid catabolic process&apos; SubClassOf &apos;auxin catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046302</classIRI>
<classLabel>2-chloro-N-isopropylacetanilide catabolic process</classLabel>
<newAxiom>&apos;2-chloro-N-isopropylacetanilide catabolic process&apos; SubClassOf &apos;xenobiotic catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046304</classIRI>
<classLabel>2-nitropropane catabolic process</classLabel>
<newAxiom>&apos;2-nitropropane catabolic process&apos; SubClassOf &apos;organic substance catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046343</classIRI>
<classLabel>streptomycin metabolic process</classLabel>
<newAxiom>&apos;streptomycin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071323</classIRI>
<classLabel>cellular response to chitin</classLabel>
<newAxiom>&apos;cellular response to chitin&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071313</classIRI>
<classLabel>cellular response to caffeine</classLabel>
<newAxiom>&apos;cellular response to caffeine&apos; SubClassOf &apos;cellular response to xenobiotic stimulus&apos;</newAxiom>
<newAxiom>&apos;cellular response to caffeine&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071315</classIRI>
<classLabel>cellular response to morphine</classLabel>
<newAxiom>&apos;cellular response to morphine&apos; SubClassOf &apos;cellular response to xenobiotic stimulus&apos;</newAxiom>
<newAxiom>&apos;cellular response to morphine&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071314</classIRI>
<classLabel>cellular response to cocaine</classLabel>
<newAxiom>&apos;cellular response to cocaine&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to cocaine&apos; SubClassOf &apos;cellular response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071316</classIRI>
<classLabel>cellular response to nicotine</classLabel>
<deletedAxiom>&apos;cellular response to nicotine&apos; SubClassOf &apos;cellular response to chemical stimulus&apos;</deletedAxiom>
<newAxiom>&apos;cellular response to nicotine&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to nicotine&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071319</classIRI>
<classLabel>cellular response to benzoic acid</classLabel>
<newAxiom>&apos;cellular response to benzoic acid&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071318</classIRI>
<classLabel>cellular response to ATP</classLabel>
<newAxiom>&apos;cellular response to ATP&apos; SubClassOf &apos;cellular response to nutrient&apos;</newAxiom>
<newAxiom>&apos;cellular response to ATP&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071302</classIRI>
<classLabel>cellular response to vitamin B2</classLabel>
<newAxiom>&apos;cellular response to vitamin B2&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071301</classIRI>
<classLabel>cellular response to vitamin B1</classLabel>
<newAxiom>&apos;cellular response to vitamin B1&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071304</classIRI>
<classLabel>cellular response to vitamin B6</classLabel>
<newAxiom>&apos;cellular response to vitamin B6&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071309</classIRI>
<classLabel>cellular response to phylloquinone</classLabel>
<newAxiom>&apos;cellular response to phylloquinone&apos; SubClassOf &apos;cellular response to vitamin&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071361</classIRI>
<classLabel>cellular response to ethanol</classLabel>
<newAxiom>&apos;cellular response to ethanol&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
<newAxiom>&apos;cellular response to ethanol&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071296</classIRI>
<classLabel>cellular response to biotin</classLabel>
<newAxiom>&apos;cellular response to biotin&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071265</classIRI>
<classLabel>L-methionine biosynthetic process</classLabel>
<newAxiom>&apos;L-methionine biosynthetic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071272</classIRI>
<classLabel>morphine metabolic process</classLabel>
<newAxiom>&apos;morphine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
<newAxiom>&apos;morphine metabolic process&apos; SubClassOf &apos;xenobiotic metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071273</classIRI>
<classLabel>morphine catabolic process</classLabel>
<newAxiom>&apos;morphine catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
<newAxiom>&apos;morphine catabolic process&apos; SubClassOf &apos;xenobiotic catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_23527</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_23527 SubClassOf http://purl.obolibrary.org/obo/GOCHE_50427</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_23527 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25442</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071297</classIRI>
<classLabel>cellular response to cobalamin</classLabel>
<newAxiom>&apos;cellular response to cobalamin&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_3165</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_3165 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_3165 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046225</classIRI>
<classLabel>bacteriocin catabolic process</classLabel>
<deletedAxiom>&apos;bacteriocin catabolic process&apos; SubClassOf &apos;detoxification of nitrogen compound&apos;</deletedAxiom>
<deletedAxiom>&apos;bacteriocin catabolic process&apos; SubClassOf &apos;toxin catabolic process&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046224</classIRI>
<classLabel>bacteriocin metabolic process</classLabel>
<deletedAxiom>&apos;bacteriocin metabolic process&apos; SubClassOf &apos;toxin metabolic process&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046210</classIRI>
<classLabel>nitric oxide catabolic process</classLabel>
<newAxiom>&apos;nitric oxide catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
<newAxiom>&apos;nitric oxide catabolic process&apos; SubClassOf &apos;neurotransmitter catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046209</classIRI>
<classLabel>nitric oxide metabolic process</classLabel>
<newAxiom>&apos;nitric oxide metabolic process&apos; SubClassOf &apos;neurotransmitter metabolic process&apos;</newAxiom>
<newAxiom>&apos;nitric oxide metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046208</classIRI>
<classLabel>spermine catabolic process</classLabel>
<newAxiom>&apos;spermine catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046244</classIRI>
<classLabel>salicylic acid catabolic process</classLabel>
<newAxiom>&apos;salicylic acid catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
<newAxiom>&apos;salicylic acid catabolic process&apos; SubClassOf &apos;hormone catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_72804</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_72804 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046230</classIRI>
<classLabel>2-aminobenzenesulfonate catabolic process</classLabel>
<newAxiom>&apos;2-aminobenzenesulfonate catabolic process&apos; SubClassOf &apos;organic acid catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046228</classIRI>
<classLabel>2,4,5-trichlorophenoxyacetic acid catabolic process</classLabel>
<newAxiom>&apos;2,4,5-trichlorophenoxyacetic acid catabolic process&apos; SubClassOf &apos;auxin catabolic process&apos;</newAxiom>
<newAxiom>&apos;2,4,5-trichlorophenoxyacetic acid catabolic process&apos; SubClassOf &apos;xenobiotic catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046269</classIRI>
<classLabel>toluene-4-sulfonate catabolic process</classLabel>
<deletedAxiom>&apos;toluene-4-sulfonate catabolic process&apos; SubClassOf &apos;small molecule catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;toluene-4-sulfonate catabolic process&apos; SubClassOf &apos;organic acid catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071245</classIRI>
<classLabel>cellular response to carbon monoxide</classLabel>
<newAxiom>&apos;cellular response to carbon monoxide&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to carbon monoxide&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071244</classIRI>
<classLabel>cellular response to carbon dioxide</classLabel>
<newAxiom>&apos;cellular response to carbon dioxide&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046285</classIRI>
<classLabel>flavonoid phytoalexin metabolic process</classLabel>
<newAxiom>&apos;flavonoid phytoalexin metabolic process&apos; SubClassOf &apos;phytoalexin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_33198</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_33198 SubClassOf http://purl.obolibrary.org/obo/GOCHE_38161</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_33198 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071231</classIRI>
<classLabel>cellular response to folic acid</classLabel>
<newAxiom>&apos;cellular response to folic acid&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046278</classIRI>
<classLabel>3,4-dihydroxybenzoate metabolic process</classLabel>
<newAxiom>&apos;3,4-dihydroxybenzoate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071236</classIRI>
<classLabel>cellular response to antibiotic</classLabel>
<deletedAxiom>&apos;cellular response to antibiotic&apos; SubClassOf &apos;cellular response to chemical stimulus&apos;</deletedAxiom>
<newAxiom>&apos;cellular response to antibiotic&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071239</classIRI>
<classLabel>cellular response to streptomycin</classLabel>
<newAxiom>&apos;cellular response to streptomycin&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071225</classIRI>
<classLabel>cellular response to muramyl dipeptide</classLabel>
<newAxiom>&apos;cellular response to muramyl dipeptide&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046296</classIRI>
<classLabel>glycolate catabolic process</classLabel>
<newAxiom>&apos;glycolate catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_72750</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_72750 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_72750 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_72765</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_72765 SubClassOf http://purl.obolibrary.org/obo/GOCHE_38632</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_72765 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25442</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_72765 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52210</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_72765 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_47898</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_47898 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_47898 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35610</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_33229</classIRI>
<deletedAxiom>http://purl.obolibrary.org/obo/CHEBI_33229 SubClassOf http://purl.obolibrary.org/obo/CHEBI_78295</deletedAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_33229 SubClassOf http://purl.obolibrary.org/obo/CHEBI_52206</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_33229 SubClassOf http://purl.obolibrary.org/obo/CHEBI_27027</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_33234</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_33234 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24020</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_33234 SubClassOf http://purl.obolibrary.org/obo/GOCHE_51086</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_23897</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_23897 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24621</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_33216</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_33216 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35703</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_33216 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_33216 SubClassOf http://purl.obolibrary.org/obo/GOCHE_51086</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_33216 SubClassOf http://purl.obolibrary.org/obo/GOCHE_50114</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_33221</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_33221 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23357</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_23872</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_23872 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35703</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_23825</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_23825 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35703</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_3098</classIRI>
<deletedAxiom>http://purl.obolibrary.org/obo/CHEBI_3098 SubClassOf http://purl.obolibrary.org/obo/CHEBI_25384</deletedAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_3098 SubClassOf http://purl.obolibrary.org/obo/CHEBI_138366</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046146</classIRI>
<classLabel>tetrahydrobiopterin metabolic process</classLabel>
<newAxiom>&apos;tetrahydrobiopterin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046147</classIRI>
<classLabel>tetrahydrobiopterin catabolic process</classLabel>
<newAxiom>&apos;tetrahydrobiopterin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
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</changedClass>
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</changedClass>
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</changedClass>
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<newAxiom>&apos;positive regulation of acetylcholine uptake&apos; SubClassOf &apos;positive regulation of neurotransmitter transport&apos;</newAxiom>
</changedClass>
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<newAxiom>&apos;negative regulation of acetylcholine uptake&apos; SubClassOf &apos;negative regulation of neurotransmitter transport&apos;</newAxiom>
</changedClass>
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<newAxiom>&apos;regulation of acetylcholine uptake&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
<newAxiom>&apos;regulation of acetylcholine uptake&apos; SubClassOf &apos;regulation of hormone levels&apos;</newAxiom>
</changedClass>
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<classLabel>iron-sulfur cluster binding</classLabel>
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</changedClass>
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<classLabel>regulation of dopamine uptake involved in synaptic transmission</classLabel>
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</changedClass>
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<classLabel>positive regulation of dopamine uptake involved in synaptic transmission</classLabel>
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</changedClass>
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<classLabel>negative regulation of dopamine uptake involved in synaptic transmission</classLabel>
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</changedClass>
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<classLabel>response to folic acid</classLabel>
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</changedClass>
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</changedClass>
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<classLabel>trans-synaptic signaling by nitric oxide</classLabel>
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<newAxiom>&apos;trans-synaptic signaling by nitric oxide&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099163</newAxiom>
</changedClass>
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</changedClass>
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</changedClass>
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</changedClass>
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</changedClass>
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</changedClass>
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</changedClass>
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</changedClass>
<changedClass>
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</changedClass>
<changedClass>
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<classLabel>corticotropin-releasing hormone binding</classLabel>
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</changedClass>
<changedClass>
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<classLabel>cellular response to forskolin</classLabel>
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</changedClass>
<changedClass>
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<classLabel>response to forskolin</classLabel>
<newAxiom>&apos;response to forskolin&apos; SubClassOf &apos;response to platelet aggregation inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
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<classLabel>cellular response to desipramine</classLabel>
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</changedClass>
<changedClass>
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<classLabel>response to desipramine</classLabel>
<newAxiom>&apos;response to desipramine&apos; SubClassOf &apos;response to antidepressant&apos;</newAxiom>
</changedClass>
<changedClass>
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<classLabel>negative regulation of cortisol secretion</classLabel>
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</changedClass>
<changedClass>
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<classLabel>regulation of cortisol secretion</classLabel>
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</changedClass>
<changedClass>
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<classLabel>response to cordycepin</classLabel>
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</changedClass>
<changedClass>
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<classLabel>negative regulation of corticotropin-releasing hormone secretion</classLabel>
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</changedClass>
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<classLabel>positive regulation of cortisol secretion</classLabel>
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</changedClass>
<changedClass>
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<classLabel>positive regulation of corticotropin-releasing hormone secretion</classLabel>
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</changedClass>
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</changedClass>
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<newAxiom>&apos;response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
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<classLabel>regulation of calcitonin secretion</classLabel>
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</changedClass>
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<classLabel>positive regulation of calcitonin secretion</classLabel>
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</changedClass>
<changedClass>
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</changedClass>
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</changedClass>
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</changedClass>
<changedClass>
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</changedClass>
<changedClass>
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<classLabel>cellular response to kainic acid</classLabel>
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</changedClass>
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</changedClass>
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</changedClass>
<changedClass>
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</changedClass>
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</changedClass>
<changedClass>
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</changedClass>
<changedClass>
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</changedClass>
<changedClass>
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</changedClass>
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</changedClass>
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</changedClass>
<changedClass>
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<classLabel>antibiotic metabolic process</classLabel>
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</changedClass>
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</changedClass>
<changedClass>
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</changedClass>
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</changedClass>
<changedClass>
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</changedClass>
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</changedClass>
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</changedClass>
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</changedClass>
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</changedClass>
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</changedClass>
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</changedClass>
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</changedClass>
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</changedClass>
<changedClass>
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</changedClass>
<changedClass>
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</changedClass>
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</changedClass>
<changedClass>
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</changedClass>
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</changedClass>
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</changedClass>
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<classLabel>postsynapse assembly</classLabel>
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</changedClass>
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</changedClass>
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</changedClass>
<changedClass>
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</changedClass>
<changedClass>
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<classLabel>presynapse assembly</classLabel>
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</changedClass>
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</changedClass>
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</changedClass>
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<newAxiom>&apos;positive regulation of androst-4-ene-3,17-dione biosynthetic process&apos; SubClassOf &apos;positive regulation of hormone biosynthetic process&apos;</newAxiom>
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</changedClass>
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<newAxiom>&apos;response to clopidogrel&apos; SubClassOf &apos;response to anticoagulant&apos;</newAxiom>
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<newAxiom>&apos;response to acetylsalicylate&apos; SubClassOf &apos;response to anticoagulant&apos;</newAxiom>
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</changedClass>
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</changedClass>
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</changedClass>
<changedClass>
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</changedClass>
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</changedClass>
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</changedClass>
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</changedClass>
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<newAxiom>&apos;glycine binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
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<newAxiom>&apos;response to L-arginine&apos; SubClassOf &apos;response to nutrient&apos;</newAxiom>
<newAxiom>&apos;response to L-arginine&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
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</changedClass>
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<changedClass>
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</changedClass>
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</changedClass>
<changedClass>
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</changedClass>
<changedClass>
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</changedClass>
<changedClass>
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</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17602 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_52090</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_52090 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_52092</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_52092 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0090416</classIRI>
<classLabel>nicotinate transmembrane transporter activity</classLabel>
<newAxiom>&apos;nicotinate transmembrane transporter activity&apos; SubClassOf &apos;vitamin transmembrane transporter activity&apos;</newAxiom>
<newAxiom>&apos;nicotinate transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
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</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_66960 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_27380 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_27386</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_27386 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_27385</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_27385 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24432</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_27385 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33232</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_66955 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_66952 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_27354</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_27354 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_27363</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_27363 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33284</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903803</classIRI>
<classLabel>L-glutamine import across plasma membrane</classLabel>
<newAxiom>&apos;L-glutamine import across plasma membrane&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903808</classIRI>
<classLabel>L-tyrosine import across plasma membrane</classLabel>
<newAxiom>&apos;L-tyrosine import across plasma membrane&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903807</classIRI>
<classLabel>L-threonine import across plasma membrane</classLabel>
<newAxiom>&apos;L-threonine import across plasma membrane&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17980</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17980 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17985</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17985 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17984</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17984 SubClassOf http://purl.obolibrary.org/obo/GOCHE_51086</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17987</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17987 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33232</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17987 SubClassOf http://purl.obolibrary.org/obo/GOCHE_51086</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17987 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903811</classIRI>
<classLabel>L-asparagine import across plasma membrane</classLabel>
<newAxiom>&apos;L-asparagine import across plasma membrane&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17992</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17992 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52211</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17992 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17992 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33232</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17996</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17996 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_27300</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_27300 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24020</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_27306</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_27306 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_27306 SubClassOf http://purl.obolibrary.org/obo/GOCHE_27314</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_133538</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_133538 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17939</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17939 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17939 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35610</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17933</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17933 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17933 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903880</classIRI>
<classLabel>17alpha-hydroxyprogesterone binding</classLabel>
<newAxiom>&apos;17alpha-hydroxyprogesterone binding&apos; SubClassOf &apos;hormone binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17929</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17929 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17968</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17968 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17968 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17962</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17962 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17950</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17950 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903791</classIRI>
<classLabel>uracil transmembrane transport</classLabel>
<newAxiom>&apos;uracil transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903794</classIRI>
<classLabel>cortisol binding</classLabel>
<newAxiom>&apos;cortisol binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903785</classIRI>
<classLabel>L-valine transmembrane transport</classLabel>
<newAxiom>&apos;L-valine transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903787</classIRI>
<classLabel>negative regulation of glutathione biosynthetic process</classLabel>
<newAxiom>&apos;negative regulation of glutathione biosynthetic process&apos; SubClassOf &apos;negative regulation of cofactor metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903786</classIRI>
<classLabel>regulation of glutathione biosynthetic process</classLabel>
<newAxiom>&apos;regulation of glutathione biosynthetic process&apos; SubClassOf &apos;regulation of cofactor metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903788</classIRI>
<classLabel>positive regulation of glutathione biosynthetic process</classLabel>
<newAxiom>&apos;positive regulation of glutathione biosynthetic process&apos; SubClassOf &apos;positive regulation of cofactor metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_27266</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_27266 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17895</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17895 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17895 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17895 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33284</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17898</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17898 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35222</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903925</classIRI>
<classLabel>response to bisphenol A</classLabel>
<newAxiom>&apos;response to bisphenol A&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
<newAxiom>&apos;response to bisphenol A&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
<newAxiom>&apos;response to bisphenol A&apos; SubClassOf &apos;response to hormone&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903924</classIRI>
<classLabel>estradiol binding</classLabel>
<newAxiom>&apos;estradiol binding&apos; SubClassOf &apos;estrogen binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903927</classIRI>
<classLabel>response to cyanide</classLabel>
<newAxiom>&apos;response to cyanide&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903926</classIRI>
<classLabel>cellular response to bisphenol A</classLabel>
<newAxiom>&apos;cellular response to bisphenol A&apos; SubClassOf &apos;cellular response to hormone stimulus&apos;</newAxiom>
<newAxiom>&apos;cellular response to bisphenol A&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to bisphenol A&apos; SubClassOf &apos;cellular response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903928</classIRI>
<classLabel>cellular response to cyanide</classLabel>
<newAxiom>&apos;cellular response to cyanide&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_27226</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_27226 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903956</classIRI>
<classLabel>response to latrunculin B</classLabel>
<newAxiom>&apos;response to latrunculin B&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903957</classIRI>
<classLabel>cellular response to latrunculin B</classLabel>
<newAxiom>&apos;cellular response to latrunculin B&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17859</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17859 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903967</classIRI>
<classLabel>response to micafungin</classLabel>
<newAxiom>&apos;response to micafungin&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903968</classIRI>
<classLabel>cellular response to micafungin</classLabel>
<newAxiom>&apos;cellular response to micafungin&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17883</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17883 SubClassOf http://purl.obolibrary.org/obo/CHEBI_138675</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17883 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903936</classIRI>
<classLabel>cellular response to sodium arsenite</classLabel>
<newAxiom>&apos;cellular response to sodium arsenite&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
<newAxiom>&apos;cellular response to sodium arsenite&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903935</classIRI>
<classLabel>response to sodium arsenite</classLabel>
<newAxiom>&apos;response to sodium arsenite&apos; SubClassOf &apos;response to herbicide&apos;</newAxiom>
<newAxiom>&apos;response to sodium arsenite&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
<newAxiom>&apos;response to sodium arsenite&apos; SubClassOf &apos;response to insecticide&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903938</classIRI>
<classLabel>cellular response to acrylamide</classLabel>
<newAxiom>&apos;cellular response to acrylamide&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903937</classIRI>
<classLabel>response to acrylamide</classLabel>
<newAxiom>&apos;response to acrylamide&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17877</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17877 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17824</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17824 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33232</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17823</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17823 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35610</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17823 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24621</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17823 SubClassOf http://purl.obolibrary.org/obo/GOCHE_38632</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17823 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17822</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17822 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17821</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17821 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17814</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17814 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17814 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17814 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17814 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52210</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031926</classIRI>
<classLabel>pyridoxal phosphate transmembrane transporter activity</classLabel>
<newAxiom>&apos;pyridoxal phosphate transmembrane transporter activity&apos; SubClassOf &apos;coenzyme transmembrane transporter activity&apos;</newAxiom>
<newAxiom>&apos;pyridoxal phosphate transmembrane transporter activity&apos; SubClassOf &apos;vitamin B6 transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031925</classIRI>
<classLabel>pyridoxal transmembrane transporter activity</classLabel>
<newAxiom>&apos;pyridoxal transmembrane transporter activity&apos; SubClassOf &apos;cofactor transmembrane transporter activity&apos;</newAxiom>
<newAxiom>&apos;pyridoxal transmembrane transporter activity&apos; SubClassOf &apos;vitamin B6 transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031928</classIRI>
<classLabel>pyridoxine transmembrane transporter activity</classLabel>
<newAxiom>&apos;pyridoxine transmembrane transporter activity&apos; SubClassOf &apos;vitamin B6 transmembrane transporter activity&apos;</newAxiom>
<newAxiom>&apos;pyridoxine transmembrane transporter activity&apos; SubClassOf &apos;cofactor transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031927</classIRI>
<classLabel>pyridoxamine transmembrane transporter activity</classLabel>
<newAxiom>&apos;pyridoxamine transmembrane transporter activity&apos; SubClassOf &apos;vitamin B6 transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031920</classIRI>
<classLabel>pyridoxal transport</classLabel>
<newAxiom>&apos;pyridoxal transport&apos; SubClassOf &apos;cofactor transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17847</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17847 SubClassOf http://purl.obolibrary.org/obo/GOCHE_27026</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031921</classIRI>
<classLabel>pyridoxal phosphate transport</classLabel>
<newAxiom>&apos;pyridoxal phosphate transport&apos; SubClassOf &apos;coenzyme transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031924</classIRI>
<classLabel>vitamin B6 transmembrane transporter activity</classLabel>
<newAxiom>&apos;vitamin B6 transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031923</classIRI>
<classLabel>pyridoxine transport</classLabel>
<newAxiom>&apos;pyridoxine transport&apos; SubClassOf &apos;cofactor transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031919</classIRI>
<classLabel>vitamin B6 transport</classLabel>
<newAxiom>&apos;vitamin B6 transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_597326</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_597326 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17836</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17836 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903981</classIRI>
<classLabel>enterobactin binding</classLabel>
<newAxiom>&apos;enterobactin binding&apos; SubClassOf &apos;cofactor binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0016208</classIRI>
<classLabel>AMP binding</classLabel>
<newAxiom>&apos;AMP binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_17905</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_17905 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23354</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_52289</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_52289 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006809</classIRI>
<classLabel>nitric oxide biosynthetic process</classLabel>
<newAxiom>&apos;nitric oxide biosynthetic process&apos; SubClassOf &apos;neurotransmitter biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_47136</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_47136 SubClassOf http://purl.obolibrary.org/obo/GOCHE_51086</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_62755</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_62755 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006837</classIRI>
<classLabel>serotonin transport</classLabel>
<newAxiom>&apos;serotonin transport&apos; SubClassOf &apos;neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_37783</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_37783 SubClassOf http://purl.obolibrary.org/obo/CHEBI_64709</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006749</classIRI>
<classLabel>glutathione metabolic process</classLabel>
<newAxiom>&apos;glutathione metabolic process&apos; SubClassOf &apos;cofactor metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006751</classIRI>
<classLabel>glutathione catabolic process</classLabel>
<newAxiom>&apos;glutathione catabolic process&apos; SubClassOf &apos;cofactor catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006750</classIRI>
<classLabel>glutathione biosynthetic process</classLabel>
<newAxiom>&apos;glutathione biosynthetic process&apos; SubClassOf &apos;cofactor biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_23243</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_23243 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006768</classIRI>
<classLabel>biotin metabolic process</classLabel>
<deletedAxiom>&apos;biotin metabolic process&apos; SubClassOf &apos;cofactor metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;biotin metabolic process&apos; SubClassOf &apos;coenzyme metabolic process&apos;</newAxiom>
<newAxiom>&apos;biotin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006769</classIRI>
<classLabel>nicotinamide metabolic process</classLabel>
<newAxiom>&apos;nicotinamide metabolic process&apos; SubClassOf &apos;cofactor metabolic process&apos;</newAxiom>
<newAxiom>&apos;nicotinamide metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_62805</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_62805 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33232</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_62805 SubClassOf http://purl.obolibrary.org/obo/GOCHE_64909</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_62805 SubClassOf http://purl.obolibrary.org/obo/GOCHE_51086</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006771</classIRI>
<classLabel>riboflavin metabolic process</classLabel>
<newAxiom>&apos;riboflavin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_13850</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_13850 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_37808</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_37808 SubClassOf http://purl.obolibrary.org/obo/CHEBI_138675</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_37808 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33232</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_37808 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52211</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0016168</classIRI>
<classLabel>chlorophyll binding</classLabel>
<newAxiom>&apos;chlorophyll binding&apos; SubClassOf &apos;cofactor binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_23089</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_23089 SubClassOf http://purl.obolibrary.org/obo/GOCHE_38161</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_37690</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_37690 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_47027</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_47027 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_47025</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_47025 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_23066</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_23066 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006704</classIRI>
<classLabel>glucocorticoid biosynthetic process</classLabel>
<newAxiom>&apos;glucocorticoid biosynthetic process&apos; SubClassOf &apos;hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_37671</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_37671 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006709</classIRI>
<classLabel>progesterone catabolic process</classLabel>
<newAxiom>&apos;progesterone catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006713</classIRI>
<classLabel>glucocorticoid catabolic process</classLabel>
<newAxiom>&apos;glucocorticoid catabolic process&apos; SubClassOf &apos;hormone catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_37684</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_37684 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_23116</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_23116 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33284</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_23128</classIRI>
<deletedAxiom>http://purl.obolibrary.org/obo/CHEBI_23128 SubClassOf http://purl.obolibrary.org/obo/CHEBI_23115</deletedAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_23128 SubClassOf http://purl.obolibrary.org/obo/CHEBI_36683</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006653</classIRI>
<classLabel>1,2-diacyl-sn-glycero-3-phosphocholine metabolic process</classLabel>
<newAxiom>&apos;1,2-diacyl-sn-glycero-3-phosphocholine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_13705</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_13705 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_62981</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_62981 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006600</classIRI>
<classLabel>creatine metabolic process</classLabel>
<newAxiom>&apos;creatine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006544</classIRI>
<classLabel>glycine metabolic process</classLabel>
<newAxiom>&apos;glycine metabolic process&apos; SubClassOf &apos;neurotransmitter metabolic process&apos;</newAxiom>
<newAxiom>&apos;glycine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006546</classIRI>
<classLabel>glycine catabolic process</classLabel>
<newAxiom>&apos;glycine catabolic process&apos; SubClassOf &apos;neurotransmitter catabolic process&apos;</newAxiom>
<newAxiom>&apos;glycine catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006545</classIRI>
<classLabel>glycine biosynthetic process</classLabel>
<newAxiom>&apos;glycine biosynthetic process&apos; SubClassOf &apos;neurotransmitter biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006559</classIRI>
<classLabel>L-phenylalanine catabolic process</classLabel>
<newAxiom>&apos;L-phenylalanine catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006558</classIRI>
<classLabel>L-phenylalanine metabolic process</classLabel>
<newAxiom>&apos;L-phenylalanine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_23436</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_23436 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031524</classIRI>
<classLabel>menthol metabolic process</classLabel>
<newAxiom>&apos;menthol metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_86992</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_86992 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52210</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_86992 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35469</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_86991</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_86991 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52210</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_86991 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35469</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006581</classIRI>
<classLabel>acetylcholine catabolic process</classLabel>
<newAxiom>&apos;acetylcholine catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
<newAxiom>&apos;acetylcholine catabolic process&apos; SubClassOf &apos;hormone catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_37931</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_37931 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_37941</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_37941 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52210</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_37941 SubClassOf http://purl.obolibrary.org/obo/GOCHE_50427</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_37941 SubClassOf http://purl.obolibrary.org/obo/GOCHE_50249</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031427</classIRI>
<classLabel>response to methotrexate</classLabel>
<newAxiom>&apos;response to methotrexate&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
<newAxiom>&apos;response to methotrexate&apos; SubClassOf &apos;response to antimetabolite&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031419</classIRI>
<classLabel>cobalamin binding</classLabel>
<newAxiom>&apos;cobalamin binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
<newAxiom>&apos;cobalamin binding&apos; SubClassOf &apos;cofactor binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031418</classIRI>
<classLabel>L-ascorbic acid binding</classLabel>
<newAxiom>&apos;L-ascorbic acid binding&apos; SubClassOf &apos;coenzyme binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070982</classIRI>
<classLabel>L-asparagine metabolic process</classLabel>
<newAxiom>&apos;L-asparagine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070968</classIRI>
<classLabel>pyrroloquinoline quinone binding</classLabel>
<newAxiom>&apos;pyrroloquinoline quinone binding&apos; SubClassOf &apos;vitamin binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_13389</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_13389 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_27998</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_27998 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33284</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_2448</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_2448 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070907</classIRI>
<classLabel>histidine:histamine antiporter activity</classLabel>
<newAxiom>&apos;histidine:histamine antiporter activity&apos; SubClassOf &apos;neurotransmitter transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070908</classIRI>
<classLabel>tyrosine:tyramine antiporter activity</classLabel>
<newAxiom>&apos;tyrosine:tyramine antiporter activity&apos; SubClassOf &apos;neurotransmitter transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_86323</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_86323 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_86323 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35222</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_86323 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52206</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070927</classIRI>
<classLabel>negative regulation of ATP:ADP antiporter activity</classLabel>
<newAxiom>&apos;negative regulation of ATP:ADP antiporter activity&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070926</classIRI>
<classLabel>regulation of ATP:ADP antiporter activity</classLabel>
<newAxiom>&apos;regulation of ATP:ADP antiporter activity&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_62265</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_62265 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24432</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_37257</classIRI>
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</changedClass>
<changedClass>
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</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_27899 SubClassOf http://purl.obolibrary.org/obo/GOCHE_64909</newAxiom>
</changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_27881 SubClassOf http://purl.obolibrary.org/obo/GOCHE_26115</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_2365 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
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</changedClass>
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</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_27928 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_27903 SubClassOf http://purl.obolibrary.org/obo/GOCHE_22676</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_27903 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35703</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_27903 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24527</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_27922 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006212</classIRI>
<classLabel>uracil catabolic process</classLabel>
<newAxiom>&apos;uracil catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_27902</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_27902 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_27902 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_27902 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070813</classIRI>
<classLabel>hydrogen sulfide metabolic process</classLabel>
<newAxiom>&apos;hydrogen sulfide metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
<newAxiom>&apos;hydrogen sulfide metabolic process&apos; SubClassOf &apos;toxin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070814</classIRI>
<classLabel>hydrogen sulfide biosynthetic process</classLabel>
<newAxiom>&apos;hydrogen sulfide biosynthetic process&apos; SubClassOf &apos;toxin biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006196</classIRI>
<classLabel>AMP catabolic process</classLabel>
<newAxiom>&apos;AMP catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0055129</classIRI>
<classLabel>L-proline biosynthetic process</classLabel>
<newAxiom>&apos;L-proline biosynthetic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031177</classIRI>
<classLabel>phosphopantetheine binding</classLabel>
<newAxiom>&apos;phosphopantetheine binding&apos; SubClassOf &apos;cofactor binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070781</classIRI>
<classLabel>response to biotin</classLabel>
<newAxiom>&apos;response to biotin&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070778</classIRI>
<classLabel>L-aspartate transport</classLabel>
<newAxiom>&apos;L-aspartate transport&apos; SubClassOf &apos;neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_37598</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_37598 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24432</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0080142</classIRI>
<classLabel>regulation of salicylic acid biosynthetic process</classLabel>
<deletedAxiom>&apos;regulation of salicylic acid biosynthetic process&apos; SubClassOf &apos;regulation of cellular biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;regulation of salicylic acid biosynthetic process&apos; SubClassOf &apos;regulation of hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0080141</classIRI>
<classLabel>regulation of jasmonic acid biosynthetic process</classLabel>
<newAxiom>&apos;regulation of jasmonic acid biosynthetic process&apos; SubClassOf &apos;regulation of hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0080151</classIRI>
<classLabel>positive regulation of salicylic acid mediated signaling pathway</classLabel>
<newAxiom>&apos;positive regulation of salicylic acid mediated signaling pathway&apos; SubClassOf &apos;positive regulation of cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0080139</classIRI>
<classLabel>borate efflux transmembrane transporter activity</classLabel>
<newAxiom>&apos;borate efflux transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0080140</classIRI>
<classLabel>regulation of jasmonic acid metabolic process</classLabel>
<newAxiom>&apos;regulation of jasmonic acid metabolic process&apos; SubClassOf &apos;regulation of hormone metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0080122</classIRI>
<classLabel>AMP transmembrane transporter activity</classLabel>
<newAxiom>&apos;AMP transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0080121</classIRI>
<classLabel>AMP transport</classLabel>
<newAxiom>&apos;AMP transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_37550</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_37550 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_37550 SubClassOf http://purl.obolibrary.org/obo/GOCHE_48705</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_37550 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33280</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_37550 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_37550 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35222</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_62501</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_62501 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_37563</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_37563 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_37565</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_37565 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_37568</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_37568 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_37537</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_37537 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35610</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_37537 SubClassOf http://purl.obolibrary.org/obo/GOCHE_48705</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0080164</classIRI>
<classLabel>regulation of nitric oxide metabolic process</classLabel>
<newAxiom>&apos;regulation of nitric oxide metabolic process&apos; SubClassOf &apos;regulation of neurotransmitter levels&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0080170</classIRI>
<classLabel>hydrogen peroxide transmembrane transport</classLabel>
<deletedAxiom>&apos;hydrogen peroxide transmembrane transport&apos; SubClassOf &apos;transmembrane transport&apos;</deletedAxiom>
<newAxiom>&apos;hydrogen peroxide transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
<newAxiom>&apos;hydrogen peroxide transmembrane transport&apos; SubClassOf &apos;cofactor transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_2679</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_2679 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35523</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_2679 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52210</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_2679 SubClassOf http://purl.obolibrary.org/obo/GOCHE_64909</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_2679 SubClassOf http://purl.obolibrary.org/obo/GOCHE_51086</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_2679 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35703</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_23007</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_23007 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_137986</classIRI>
<deletedAxiom>http://purl.obolibrary.org/obo/CHEBI_137986 SubClassOf http://purl.obolibrary.org/obo/CHEBI_15841</deletedAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_137986 SubClassOf http://purl.obolibrary.org/obo/CHEBI_27369</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_137982</classIRI>
<deletedAxiom>http://purl.obolibrary.org/obo/CHEBI_137982 SubClassOf http://purl.obolibrary.org/obo/CHEBI_50860</deletedAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_137982 SubClassOf http://purl.obolibrary.org/obo/CHEBI_25697</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_2639</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_2639 SubClassOf http://purl.obolibrary.org/obo/GOCHE_38632</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_2639 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35498</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006103</classIRI>
<classLabel>2-oxoglutarate metabolic process</classLabel>
<newAxiom>&apos;2-oxoglutarate metabolic process&apos; SubClassOf &apos;cofactor metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006105</classIRI>
<classLabel>succinate metabolic process</classLabel>
<newAxiom>&apos;succinate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006154</classIRI>
<classLabel>adenosine catabolic process</classLabel>
<newAxiom>&apos;adenosine catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070639</classIRI>
<classLabel>vitamin D2 metabolic process</classLabel>
<newAxiom>&apos;vitamin D2 metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_86478</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_86478 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_40</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_40 SubClassOf http://purl.obolibrary.org/obo/GOCHE_50114</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_40 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_40 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_62490</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_62490 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_62457</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_62457 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070640</classIRI>
<classLabel>vitamin D3 metabolic process</classLabel>
<newAxiom>&apos;vitamin D3 metabolic process&apos; SubClassOf &apos;hormone metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0080021</classIRI>
<classLabel>response to benzoic acid</classLabel>
<newAxiom>&apos;response to benzoic acid&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070689</classIRI>
<classLabel>L-threonine catabolic process to propionate</classLabel>
<newAxiom>&apos;L-threonine catabolic process to propionate&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070690</classIRI>
<classLabel>L-threonine catabolic process to acetyl-CoA</classLabel>
<newAxiom>&apos;L-threonine catabolic process to acetyl-CoA&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_37440</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_37440 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_13534</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_13534 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_86420</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_86420 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_86426</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_86426 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006030</classIRI>
<classLabel>chitin metabolic process</classLabel>
<newAxiom>&apos;chitin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006032</classIRI>
<classLabel>chitin catabolic process</classLabel>
<newAxiom>&apos;chitin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006054</classIRI>
<classLabel>N-acetylneuraminate metabolic process</classLabel>
<newAxiom>&apos;N-acetylneuraminate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006067</classIRI>
<classLabel>ethanol metabolic process</classLabel>
<newAxiom>&apos;ethanol metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031000</classIRI>
<classLabel>response to caffeine</classLabel>
<newAxiom>&apos;response to caffeine&apos; SubClassOf &apos;response to diuretic&apos;</newAxiom>
<newAxiom>&apos;response to caffeine&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006068</classIRI>
<classLabel>ethanol catabolic process</classLabel>
<newAxiom>&apos;ethanol catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033574</classIRI>
<classLabel>response to testosterone</classLabel>
<newAxiom>&apos;response to testosterone&apos; SubClassOf &apos;response to hormone&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033595</classIRI>
<classLabel>response to genistein</classLabel>
<newAxiom>&apos;response to genistein&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
<newAxiom>&apos;response to genistein&apos; SubClassOf &apos;response to hormone&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033590</classIRI>
<classLabel>response to cobalamin</classLabel>
<newAxiom>&apos;response to cobalamin&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_20140</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_20140 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35703</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_58759</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_58759 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_34779</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_34779 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24432</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_34779 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25944</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0008517</classIRI>
<classLabel>folic acid transmembrane transporter activity</classLabel>
<newAxiom>&apos;folic acid transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0008520</classIRI>
<classLabel>L-ascorbate:sodium symporter activity</classLabel>
<deletedAxiom>&apos;L-ascorbate:sodium symporter activity&apos; SubClassOf &apos;monosaccharide transmembrane transporter activity&apos;</deletedAxiom>
<deletedAxiom>&apos;L-ascorbate:sodium symporter activity&apos; SubClassOf &apos;carboxylic acid transmembrane transporter activity&apos;</deletedAxiom>
<newAxiom>&apos;L-ascorbate:sodium symporter activity&apos; SubClassOf &apos;L-ascorbic acid transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_34768</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_34768 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_34768 SubClassOf http://purl.obolibrary.org/obo/GOCHE_51086</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_58723</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_58723 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_58720</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_58720 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033510</classIRI>
<classLabel>luteolin metabolic process</classLabel>
<newAxiom>&apos;luteolin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_58702</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_58702 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033517</classIRI>
<classLabel>myo-inositol hexakisphosphate metabolic process</classLabel>
<newAxiom>&apos;myo-inositol hexakisphosphate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033494</classIRI>
<classLabel>ferulate metabolic process</classLabel>
<newAxiom>&apos;ferulate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_58593</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_58593 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_58595</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_58595 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_58695</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_58695 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_20067</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_20067 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_34687</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_34687 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_34687 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_58658</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_58658 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_175901</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_175901 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_175901 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35703</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_175901 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35610</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_175901 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35221</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_175901 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_19062</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_19062 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_10642</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_10642 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033329</classIRI>
<classLabel>kaempferol O-glucoside metabolic process</classLabel>
<newAxiom>&apos;kaempferol O-glucoside metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_34905</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_34905 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24527</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_20392</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_20392 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033306</classIRI>
<classLabel>phytol metabolic process</classLabel>
<newAxiom>&apos;phytol metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033249</classIRI>
<classLabel>positive regulation of penicillin catabolic process</classLabel>
<newAxiom>&apos;positive regulation of penicillin catabolic process&apos; SubClassOf &apos;positive regulation of response to stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033248</classIRI>
<classLabel>negative regulation of penicillin catabolic process</classLabel>
<newAxiom>&apos;negative regulation of penicillin catabolic process&apos; SubClassOf &apos;negative regulation of response to stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0008292</classIRI>
<classLabel>acetylcholine biosynthetic process</classLabel>
<newAxiom>&apos;acetylcholine biosynthetic process&apos; SubClassOf &apos;hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0008291</classIRI>
<classLabel>acetylcholine metabolic process</classLabel>
<newAxiom>&apos;acetylcholine metabolic process&apos; SubClassOf &apos;hormone metabolic process&apos;</newAxiom>
<newAxiom>&apos;acetylcholine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033247</classIRI>
<classLabel>regulation of penicillin catabolic process</classLabel>
<newAxiom>&apos;regulation of penicillin catabolic process&apos; SubClassOf &apos;regulation of response to stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033274</classIRI>
<classLabel>response to vitamin B2</classLabel>
<newAxiom>&apos;response to vitamin B2&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033272</classIRI>
<classLabel>myo-inositol hexakisphosphate transport</classLabel>
<newAxiom>&apos;myo-inositol hexakisphosphate transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033265</classIRI>
<classLabel>choline binding</classLabel>
<newAxiom>&apos;choline binding&apos; SubClassOf &apos;neurotransmitter binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_44185</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_44185 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_44185 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35221</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_44185 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35610</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_58855</classIRI>
<deletedAxiom>http://purl.obolibrary.org/obo/CHEBI_58855 SubClassOf http://purl.obolibrary.org/obo/CHEBI_35274</deletedAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_58855 SubClassOf http://purl.obolibrary.org/obo/CHEBI_137419</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_34892</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_34892 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52210</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_34892 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35610</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_136184</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_136184 SubClassOf http://purl.obolibrary.org/obo/GOCHE_37848</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0008211</classIRI>
<classLabel>glucocorticoid metabolic process</classLabel>
<newAxiom>&apos;glucocorticoid metabolic process&apos; SubClassOf &apos;hormone metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0008215</classIRI>
<classLabel>spermine metabolic process</classLabel>
<newAxiom>&apos;spermine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_34848</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_34848 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0008226</classIRI>
<classLabel>tyramine receptor activity</classLabel>
<newAxiom>&apos;tyramine receptor activity&apos; SubClassOf &apos;G-protein coupled neurotransmitter receptor activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072723</classIRI>
<classLabel>cellular response to amitrole</classLabel>
<newAxiom>&apos;cellular response to amitrole&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072722</classIRI>
<classLabel>response to amitrole</classLabel>
<newAxiom>&apos;response to amitrole&apos; SubClassOf &apos;response to herbicide&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072710</classIRI>
<classLabel>response to hydroxyurea</classLabel>
<newAxiom>&apos;response to hydroxyurea&apos; SubClassOf &apos;response to antimetabolite&apos;</newAxiom>
<newAxiom>&apos;response to hydroxyurea&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072712</classIRI>
<classLabel>response to thiabendazole</classLabel>
<newAxiom>&apos;response to thiabendazole&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
<newAxiom>&apos;response to thiabendazole&apos; SubClassOf &apos;response to fungicide&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072711</classIRI>
<classLabel>cellular response to hydroxyurea</classLabel>
<newAxiom>&apos;cellular response to hydroxyurea&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072713</classIRI>
<classLabel>cellular response to thiabendazole</classLabel>
<newAxiom>&apos;cellular response to thiabendazole&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to thiabendazole&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072718</classIRI>
<classLabel>response to cisplatin</classLabel>
<deletedAxiom>&apos;response to cisplatin&apos; SubClassOf &apos;response to chemical&apos;</deletedAxiom>
<newAxiom>&apos;response to cisplatin&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
<newAxiom>&apos;response to cisplatin&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072719</classIRI>
<classLabel>cellular response to cisplatin</classLabel>
<deletedAxiom>&apos;cellular response to cisplatin&apos; SubClassOf &apos;cellular response to chemical stimulus&apos;</deletedAxiom>
<newAxiom>&apos;cellular response to cisplatin&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to cisplatin&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072762</classIRI>
<classLabel>cellular response to carbendazim</classLabel>
<newAxiom>&apos;cellular response to carbendazim&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to carbendazim&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072764</classIRI>
<classLabel>cellular response to reversine</classLabel>
<newAxiom>&apos;cellular response to reversine&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_58280</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_58280 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072752</classIRI>
<classLabel>cellular response to rapamycin</classLabel>
<newAxiom>&apos;cellular response to rapamycin&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072756</classIRI>
<classLabel>cellular response to paraquat</classLabel>
<newAxiom>&apos;cellular response to paraquat&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072755</classIRI>
<classLabel>cellular response to benomyl</classLabel>
<newAxiom>&apos;cellular response to benomyl&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
<newAxiom>&apos;cellular response to benomyl&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072757</classIRI>
<classLabel>cellular response to camptothecin</classLabel>
<newAxiom>&apos;cellular response to camptothecin&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033198</classIRI>
<classLabel>response to ATP</classLabel>
<newAxiom>&apos;response to ATP&apos; SubClassOf &apos;response to nutrient&apos;</newAxiom>
<newAxiom>&apos;response to ATP&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_58277</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_58277 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_6887</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_6887 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52210</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_6887 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35471</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_58273</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_58273 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072743</classIRI>
<classLabel>cellular response to erythromycin</classLabel>
<newAxiom>&apos;cellular response to erythromycin&apos; SubClassOf &apos;cellular response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072744</classIRI>
<classLabel>cellular response to trichodermin</classLabel>
<newAxiom>&apos;cellular response to trichodermin&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072747</classIRI>
<classLabel>cellular response to chloramphenicol</classLabel>
<newAxiom>&apos;cellular response to chloramphenicol&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072746</classIRI>
<classLabel>cellular response to tetracycline</classLabel>
<newAxiom>&apos;cellular response to tetracycline&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072749</classIRI>
<classLabel>cellular response to cytochalasin B</classLabel>
<newAxiom>&apos;cellular response to cytochalasin B&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to cytochalasin B&apos; SubClassOf &apos;cellular response to mycotoxin&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072748</classIRI>
<classLabel>cellular response to tacrolimus</classLabel>
<deletedAxiom>&apos;cellular response to tacrolimus&apos; SubClassOf &apos;cellular response to chemical stimulus&apos;</deletedAxiom>
<newAxiom>&apos;cellular response to tacrolimus&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_58249</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_58249 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_58245</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_58245 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_58243</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_58243 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_58228</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_58228 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
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<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28826 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33232</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28826 SubClassOf http://purl.obolibrary.org/obo/CHEBI_46695</newAxiom>
</changedClass>
<changedClass>
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<changedClass>
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</changedClass>
<changedClass>
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<classLabel>coenzyme gamma-F420-2 metabolic process</classLabel>
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</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0052653</classIRI>
<classLabel>3&apos;,5&apos;-cyclic diguanylic acid metabolic process</classLabel>
<newAxiom>&apos;3&apos;,5&apos;-cyclic diguanylic acid metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28934 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28934 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28934 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25944</newAxiom>
</changedClass>
<changedClass>
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<deletedAxiom>http://purl.obolibrary.org/obo/CHEBI_77805 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24028</deletedAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_77805 SubClassOf http://purl.obolibrary.org/obo/GOCHE_26672</newAxiom>
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</changedClass>
<changedClass>
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</changedClass>
<changedClass>
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<classLabel>mitochondrial ATP transmembrane transport</classLabel>
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<changedClass>
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<classLabel>mitochondrial S-adenosyl-L-methionine transmembrane transport</classLabel>
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<deletedAxiom>&apos;mitochondrial S-adenosyl-L-methionine transmembrane transport&apos; SubClassOf &apos;sulfur compound transport&apos;</deletedAxiom>
<deletedAxiom>&apos;mitochondrial S-adenosyl-L-methionine transmembrane transport&apos; SubClassOf &apos;organic substance transport&apos;</deletedAxiom>
<newAxiom>&apos;mitochondrial S-adenosyl-L-methionine transmembrane transport&apos; SubClassOf &apos;S-adenosyl-L-methionine transmembrane transport&apos;</newAxiom>
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</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_87114 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24127</newAxiom>
</changedClass>
<changedClass>
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<changedClass>
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<deletedAxiom>http://purl.obolibrary.org/obo/CHEBI_38150 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24028</deletedAxiom>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28787 SubClassOf http://purl.obolibrary.org/obo/GOCHE_51086</newAxiom>
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</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28790 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25512</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28790 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
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</changedClass>
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</changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28747 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28747 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33232</newAxiom>
</changedClass>
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</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28723 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28716</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28716 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28716 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28800 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28808</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28808 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28815</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28815 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28813</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28813 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_63163</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_63163 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902023</classIRI>
<classLabel>L-arginine transport</classLabel>
<newAxiom>&apos;L-arginine transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902022</classIRI>
<classLabel>L-lysine transport</classLabel>
<newAxiom>&apos;L-lysine transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902024</classIRI>
<classLabel>L-histidine transport</classLabel>
<newAxiom>&apos;L-histidine transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902065</classIRI>
<classLabel>response to L-glutamate</classLabel>
<newAxiom>&apos;response to L-glutamate&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
<newAxiom>&apos;response to L-glutamate&apos; SubClassOf &apos;response to nutrient&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902066</classIRI>
<classLabel>regulation of cell wall pectin metabolic process</classLabel>
<newAxiom>&apos;regulation of cell wall pectin metabolic process&apos; SubClassOf &apos;regulation of cellular metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902049</classIRI>
<classLabel>neosartoricin catabolic process</classLabel>
<newAxiom>&apos;neosartoricin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902048</classIRI>
<classLabel>neosartoricin metabolic process</classLabel>
<newAxiom>&apos;neosartoricin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902056</classIRI>
<classLabel>(25S)-Delta(7)-dafachronate metabolic process</classLabel>
<newAxiom>&apos;(25S)-Delta(7)-dafachronate metabolic process&apos; SubClassOf &apos;hormone metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902057</classIRI>
<classLabel>(25S)-Delta(4)-dafachronate metabolic process</classLabel>
<newAxiom>&apos;(25S)-Delta(4)-dafachronate metabolic process&apos; SubClassOf &apos;hormone metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902085</classIRI>
<classLabel>fumagillin catabolic process</classLabel>
<newAxiom>&apos;fumagillin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902084</classIRI>
<classLabel>fumagillin metabolic process</classLabel>
<newAxiom>&apos;fumagillin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902098</classIRI>
<classLabel>calcitriol binding</classLabel>
<newAxiom>&apos;calcitriol binding&apos; SubClassOf &apos;hormone binding&apos;</newAxiom>
<newAxiom>&apos;calcitriol binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28997</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28997 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28995</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28995 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_14314</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_14314 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28976</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28976 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28938</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28938 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28937</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28937 SubClassOf http://purl.obolibrary.org/obo/GOCHE_37848</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_14336</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_14336 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28940</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28940 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_14321</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_14321 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042950</classIRI>
<classLabel>salicin transmembrane transporter activity</classLabel>
<newAxiom>&apos;salicin transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042945</classIRI>
<classLabel>D-serine transmembrane transporter activity</classLabel>
<newAxiom>&apos;D-serine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042942</classIRI>
<classLabel>D-serine transport</classLabel>
<newAxiom>&apos;D-serine transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902118</classIRI>
<classLabel>calcidiol binding</classLabel>
<newAxiom>&apos;calcidiol binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042948</classIRI>
<classLabel>salicin transport</classLabel>
<newAxiom>&apos;salicin transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902122</classIRI>
<classLabel>chenodeoxycholic acid binding</classLabel>
<newAxiom>&apos;chenodeoxycholic acid binding&apos; SubClassOf &apos;steroid binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902121</classIRI>
<classLabel>lithocholic acid binding</classLabel>
<newAxiom>&apos;lithocholic acid binding&apos; SubClassOf &apos;steroid binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902124</classIRI>
<classLabel>(+)-pinoresinol metabolic process</classLabel>
<newAxiom>&apos;(+)-pinoresinol metabolic process&apos; SubClassOf &apos;hormone metabolic process&apos;</newAxiom>
<newAxiom>&apos;(+)-pinoresinol metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902126</classIRI>
<classLabel>(+)-pinoresinol biosynthetic process</classLabel>
<newAxiom>&apos;(+)-pinoresinol biosynthetic process&apos; SubClassOf &apos;hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902125</classIRI>
<classLabel>(+)-pinoresinol catabolic process</classLabel>
<newAxiom>&apos;(+)-pinoresinol catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
<newAxiom>&apos;(+)-pinoresinol catabolic process&apos; SubClassOf &apos;hormone catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902137</classIRI>
<classLabel>(-)-secoisolariciresinol catabolic process</classLabel>
<newAxiom>&apos;(-)-secoisolariciresinol catabolic process&apos; SubClassOf &apos;hormone catabolic process&apos;</newAxiom>
<newAxiom>&apos;(-)-secoisolariciresinol catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902136</classIRI>
<classLabel>(-)-secoisolariciresinol metabolic process</classLabel>
<newAxiom>&apos;(-)-secoisolariciresinol metabolic process&apos; SubClassOf &apos;hormone metabolic process&apos;</newAxiom>
<newAxiom>&apos;(-)-secoisolariciresinol metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902138</classIRI>
<classLabel>(-)-secoisolariciresinol biosynthetic process</classLabel>
<newAxiom>&apos;(-)-secoisolariciresinol biosynthetic process&apos; SubClassOf &apos;hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902180</classIRI>
<classLabel>verruculogen catabolic process</classLabel>
<newAxiom>&apos;verruculogen catabolic process&apos; SubClassOf &apos;mycotoxin catabolic process&apos;</newAxiom>
<newAxiom>&apos;verruculogen catabolic process&apos; SubClassOf &apos;detoxification of nitrogen compound&apos;</newAxiom>
<newAxiom>&apos;verruculogen catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902181</classIRI>
<classLabel>verruculogen biosynthetic process</classLabel>
<deletedAxiom>&apos;verruculogen biosynthetic process&apos; SubClassOf &apos;secondary metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;verruculogen biosynthetic process&apos; SubClassOf &apos;mycotoxin biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_77932</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_77932 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_77932 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_77932 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902179</classIRI>
<classLabel>verruculogen metabolic process</classLabel>
<newAxiom>&apos;verruculogen metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
<newAxiom>&apos;verruculogen metabolic process&apos; SubClassOf &apos;mycotoxin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28484</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28484 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28499</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28499 SubClassOf http://purl.obolibrary.org/obo/CHEBI_138726</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28499 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28499 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28498</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28498 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35610</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28498 SubClassOf http://purl.obolibrary.org/obo/GOCHE_50427</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28460</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28460 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28460 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_77444</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_77444 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28426</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28426 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28428</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28428 SubClassOf http://purl.obolibrary.org/obo/GOCHE_51086</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28428 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25944</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28436</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28436 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35610</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28436 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28436 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52208</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042919</classIRI>
<classLabel>benzoate transport</classLabel>
<newAxiom>&apos;benzoate transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042905</classIRI>
<classLabel>9-cis-retinoic acid metabolic process</classLabel>
<newAxiom>&apos;9-cis-retinoic acid metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042935</classIRI>
<classLabel>achromobactin transport</classLabel>
<deletedAxiom>&apos;achromobactin transport&apos; SubClassOf &apos;cofactor transport&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042934</classIRI>
<classLabel>achromobactin transmembrane transporter activity</classLabel>
<deletedAxiom>&apos;achromobactin transmembrane transporter activity&apos; SubClassOf &apos;cofactor transmembrane transporter activity&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2001142</classIRI>
<classLabel>nicotinate transport</classLabel>
<newAxiom>&apos;nicotinate transport&apos; SubClassOf &apos;vitamin transport&apos;</newAxiom>
<newAxiom>&apos;nicotinate transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042925</classIRI>
<classLabel>benzoate transmembrane transporter activity</classLabel>
<newAxiom>&apos;benzoate transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042836</classIRI>
<classLabel>D-glucarate metabolic process</classLabel>
<newAxiom>&apos;D-glucarate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2001121</classIRI>
<classLabel>coenzyme gamma-F420-2 biosynthetic process</classLabel>
<newAxiom>&apos;coenzyme gamma-F420-2 biosynthetic process&apos; SubClassOf &apos;coenzyme biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902224</classIRI>
<classLabel>ketone body metabolic process</classLabel>
<newAxiom>&apos;ketone body metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042838</classIRI>
<classLabel>D-glucarate catabolic process</classLabel>
<newAxiom>&apos;D-glucarate catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2001132</classIRI>
<classLabel>methane biosynthetic process from 3-(methylthio)propionic acid</classLabel>
<newAxiom>&apos;methane biosynthetic process from 3-(methylthio)propionic acid&apos; SubClassOf &apos;toxin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042822</classIRI>
<classLabel>pyridoxal phosphate metabolic process</classLabel>
<deletedAxiom>&apos;pyridoxal phosphate metabolic process&apos; SubClassOf &apos;cofactor metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;pyridoxal phosphate metabolic process&apos; SubClassOf &apos;coenzyme metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042821</classIRI>
<classLabel>pyridoxal biosynthetic process</classLabel>
<newAxiom>&apos;pyridoxal biosynthetic process&apos; SubClassOf &apos;cofactor biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042820</classIRI>
<classLabel>vitamin B6 catabolic process</classLabel>
<newAxiom>&apos;vitamin B6 catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2001134</classIRI>
<classLabel>methane biosynthetic process from carbon monoxide</classLabel>
<newAxiom>&apos;methane biosynthetic process from carbon monoxide&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
<newAxiom>&apos;methane biosynthetic process from carbon monoxide&apos; SubClassOf &apos;neurotransmitter metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042878</classIRI>
<classLabel>D-glucarate transmembrane transporter activity</classLabel>
<newAxiom>&apos;D-glucarate transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042870</classIRI>
<classLabel>D-glucarate transport</classLabel>
<newAxiom>&apos;D-glucarate transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902270</classIRI>
<classLabel>(R)-carnitine transmembrane transport</classLabel>
<newAxiom>&apos;(R)-carnitine transmembrane transport&apos; SubClassOf &apos;vitamin transmembrane transport&apos;</newAxiom>
<newAxiom>&apos;(R)-carnitine transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902272</classIRI>
<classLabel>regulation of (R)-carnitine transmembrane transport</classLabel>
<newAxiom>&apos;regulation of (R)-carnitine transmembrane transport&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902274</classIRI>
<classLabel>positive regulation of (R)-carnitine transmembrane transport</classLabel>
<newAxiom>&apos;positive regulation of (R)-carnitine transmembrane transport&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902273</classIRI>
<classLabel>negative regulation of (R)-carnitine transmembrane transport</classLabel>
<newAxiom>&apos;negative regulation of (R)-carnitine transmembrane transport&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042895</classIRI>
<classLabel>antibiotic transmembrane transporter activity</classLabel>
<newAxiom>&apos;antibiotic transmembrane transporter activity&apos; SubClassOf &apos;toxin transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042891</classIRI>
<classLabel>antibiotic transport</classLabel>
<newAxiom>&apos;antibiotic transport&apos; SubClassOf &apos;toxin transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1990818</classIRI>
<classLabel>L-arginine transmembrane export from vacuole</classLabel>
<newAxiom>&apos;L-arginine transmembrane export from vacuole&apos; SubClassOf &apos;drug transmembrane export&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_1941</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_1941 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28368</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28368 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28368 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28368 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28368 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_43966</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_43966 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_43966 SubClassOf http://purl.obolibrary.org/obo/GOCHE_50249</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28358</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28358 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33232</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28358 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52211</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28324</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28324 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28328</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28328 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28300</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28300 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28304</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28304 SubClassOf http://purl.obolibrary.org/obo/GOCHE_50249</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_77396</classIRI>
<deletedAxiom>http://purl.obolibrary.org/obo/CHEBI_77396 SubClassOf http://purl.obolibrary.org/obo/CHEBI_15734</deletedAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_77396 SubClassOf http://purl.obolibrary.org/obo/CHEBI_138088</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2001063</classIRI>
<classLabel>glucomannan binding</classLabel>
<newAxiom>&apos;glucomannan binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042817</classIRI>
<classLabel>pyridoxal metabolic process</classLabel>
<newAxiom>&apos;pyridoxal metabolic process&apos; SubClassOf &apos;cofactor metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042816</classIRI>
<classLabel>vitamin B6 metabolic process</classLabel>
<newAxiom>&apos;vitamin B6 metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_18917</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_18917 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33232</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_18918</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_18918 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25944</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2001004</classIRI>
<classLabel>negative regulation of pectin catabolic process</classLabel>
<deletedAxiom>&apos;negative regulation of pectin catabolic process&apos; SubClassOf &apos;negative regulation of catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of pectin catabolic process&apos; SubClassOf &apos;negative regulation of cellular catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902348</classIRI>
<classLabel>cellular response to strigolactone</classLabel>
<newAxiom>&apos;cellular response to strigolactone&apos; SubClassOf &apos;cellular response to hormone stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902347</classIRI>
<classLabel>response to strigolactone</classLabel>
<newAxiom>&apos;response to strigolactone&apos; SubClassOf &apos;response to hormone&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902349</classIRI>
<classLabel>response to chloroquine</classLabel>
<newAxiom>&apos;response to chloroquine&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2001005</classIRI>
<classLabel>positive regulation of pectin catabolic process</classLabel>
<deletedAxiom>&apos;positive regulation of pectin catabolic process&apos; SubClassOf &apos;positive regulation of catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;positive regulation of pectin catabolic process&apos; SubClassOf &apos;positive regulation of cellular catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902351</classIRI>
<classLabel>response to imidacloprid</classLabel>
<newAxiom>&apos;response to imidacloprid&apos; SubClassOf &apos;response to insecticide&apos;</newAxiom>
<newAxiom>&apos;response to imidacloprid&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
<newAxiom>&apos;response to imidacloprid&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902350</classIRI>
<classLabel>cellular response to chloroquine</classLabel>
<newAxiom>&apos;cellular response to chloroquine&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042701</classIRI>
<classLabel>progesterone secretion</classLabel>
<newAxiom>&apos;progesterone secretion&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042725</classIRI>
<classLabel>thiamine-containing compound catabolic process</classLabel>
<newAxiom>&apos;thiamine-containing compound catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042723</classIRI>
<classLabel>thiamine-containing compound metabolic process</classLabel>
<newAxiom>&apos;thiamine-containing compound metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902384</classIRI>
<classLabel>glycyrrhetinate metabolic process</classLabel>
<newAxiom>&apos;glycyrrhetinate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902385</classIRI>
<classLabel>glycyrrhetinate catabolic process</classLabel>
<newAxiom>&apos;glycyrrhetinate catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042744</classIRI>
<classLabel>hydrogen peroxide catabolic process</classLabel>
<deletedAxiom>&apos;hydrogen peroxide catabolic process&apos; SubClassOf &apos;cellular catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;hydrogen peroxide catabolic process&apos; SubClassOf &apos;cofactor catabolic process&apos;</newAxiom>
<newAxiom>&apos;hydrogen peroxide catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042743</classIRI>
<classLabel>hydrogen peroxide metabolic process</classLabel>
<newAxiom>&apos;hydrogen peroxide metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
<newAxiom>&apos;hydrogen peroxide metabolic process&apos; SubClassOf &apos;cofactor metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28384</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28384 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24020</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28384 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28386</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28386 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28398</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28398 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28398 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33232</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28398 SubClassOf http://purl.obolibrary.org/obo/GOCHE_51086</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_77659</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_77659 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_77659 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_77659 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35610</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_38028</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_38028 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35703</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0052074</classIRI>
<classLabel>positive regulation by symbiont of host salicylic acid-mediated defense response</classLabel>
<newAxiom>&apos;positive regulation by symbiont of host salicylic acid-mediated defense response&apos; SubClassOf &apos;positive regulation of cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28681</classIRI>
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</changedClass>
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</changedClass>
<changedClass>
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</changedClass>
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</changedClass>
<changedClass>
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</changedClass>
<changedClass>
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</changedClass>
<changedClass>
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</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28666 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_87061 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24127</newAxiom>
</changedClass>
<changedClass>
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</changedClass>
<changedClass>
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</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902519</classIRI>
<classLabel>response to docetaxel trihydrate</classLabel>
<deletedAxiom>&apos;response to docetaxel trihydrate&apos; SubClassOf &apos;response to chemical&apos;</deletedAxiom>
<newAxiom>&apos;response to docetaxel trihydrate&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902518</classIRI>
<classLabel>response to cyclophosphamide</classLabel>
<newAxiom>&apos;response to cyclophosphamide&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
<newAxiom>&apos;response to cyclophosphamide&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28659</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28659 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33284</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28619 SubClassOf http://purl.obolibrary.org/obo/GOCHE_51086</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28619 SubClassOf http://purl.obolibrary.org/obo/GOCHE_64909</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28618 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24852</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_87071 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
</changedClass>
<changedClass>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28624 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28621</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28621 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35195</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28631</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28631 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28631 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28635</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28635 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28602</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28602 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28600</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28600 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28600 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28616</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28616 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902522</classIRI>
<classLabel>response to 4&apos;-epidoxorubicin</classLabel>
<newAxiom>&apos;response to 4&apos;-epidoxorubicin&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902521</classIRI>
<classLabel>response to etoposide</classLabel>
<newAxiom>&apos;response to etoposide&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042616</classIRI>
<classLabel>paclitaxel metabolic process</classLabel>
<newAxiom>&apos;paclitaxel metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902444</classIRI>
<classLabel>riboflavin binding</classLabel>
<newAxiom>&apos;riboflavin binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
<newAxiom>&apos;riboflavin binding&apos; SubClassOf &apos;vitamin binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_132297</classIRI>
<deletedAxiom>http://purl.obolibrary.org/obo/CHEBI_132297 SubClassOf http://purl.obolibrary.org/obo/CHEBI_25697</deletedAxiom>
<deletedAxiom>http://purl.obolibrary.org/obo/CHEBI_132297 SubClassOf http://purl.obolibrary.org/obo/CHEBI_35274</deletedAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_132297 SubClassOf http://purl.obolibrary.org/obo/CHEBI_137419</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2001309</classIRI>
<classLabel>gliotoxin catabolic process</classLabel>
<newAxiom>&apos;gliotoxin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2001308</classIRI>
<classLabel>gliotoxin metabolic process</classLabel>
<newAxiom>&apos;gliotoxin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902497</classIRI>
<classLabel>iron-sulfur cluster transport</classLabel>
<newAxiom>&apos;iron-sulfur cluster transport&apos; SubClassOf &apos;cofactor transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0052004</classIRI>
<classLabel>negative regulation by symbiont of host salicylic acid-mediated defense response</classLabel>
<newAxiom>&apos;negative regulation by symbiont of host salicylic acid-mediated defense response&apos; SubClassOf &apos;negative regulation of cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_63070</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_63070 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28591</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28591 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28591 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28591 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28591 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_28579</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_28579 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902670</classIRI>
<classLabel>carbon dioxide binding</classLabel>
<deletedAxiom>&apos;carbon dioxide binding&apos; SubClassOf &apos;binding&apos;</deletedAxiom>
<newAxiom>&apos;carbon dioxide binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2001292</classIRI>
<classLabel>codeine catabolic process</classLabel>
<newAxiom>&apos;codeine catabolic process&apos; SubClassOf &apos;xenobiotic catabolic process&apos;</newAxiom>
<newAxiom>&apos;codeine catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2001291</classIRI>
<classLabel>codeine metabolic process</classLabel>
<newAxiom>&apos;codeine metabolic process&apos; SubClassOf &apos;xenobiotic metabolic process&apos;</newAxiom>
<newAxiom>&apos;codeine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902599</classIRI>
<classLabel>sulfathiazole transmembrane transport</classLabel>
<deletedAxiom>&apos;sulfathiazole transmembrane transport&apos; SubClassOf &apos;transmembrane transport&apos;</deletedAxiom>
<newAxiom>&apos;sulfathiazole transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902598</classIRI>
<classLabel>creatine transmembrane transport</classLabel>
<newAxiom>&apos;creatine transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2001227</classIRI>
<classLabel>quercitrin binding</classLabel>
<newAxiom>&apos;quercitrin binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042542</classIRI>
<classLabel>response to hydrogen peroxide</classLabel>
<newAxiom>&apos;response to hydrogen peroxide&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
<newAxiom>&apos;response to hydrogen peroxide&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_327995</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_327995 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25512</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_327995 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902708</classIRI>
<classLabel>response to plumbagin</classLabel>
<newAxiom>&apos;response to plumbagin&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
<newAxiom>&apos;response to plumbagin&apos; SubClassOf &apos;response to anticoagulant&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902709</classIRI>
<classLabel>cellular response to plumbagin</classLabel>
<newAxiom>&apos;cellular response to plumbagin&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902712</classIRI>
<classLabel>G-protein coupled GABA receptor complex</classLabel>
<newAxiom>&apos;G-protein coupled GABA receptor complex&apos; SubClassOf &apos;neurotransmitter receptor complex&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902788</classIRI>
<classLabel>response to isooctane</classLabel>
<newAxiom>&apos;response to isooctane&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902789</classIRI>
<classLabel>cellular response to isooctane</classLabel>
<newAxiom>&apos;cellular response to isooctane&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_24469</classIRI>
<deletedAxiom>http://purl.obolibrary.org/obo/CHEBI_24469 SubClassOf http://purl.obolibrary.org/obo/CHEBI_24472</deletedAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_24469 SubClassOf http://purl.obolibrary.org/obo/CHEBI_36684</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902777</classIRI>
<classLabel>6-sulfoquinovose(1-) catabolic process</classLabel>
<newAxiom>&apos;6-sulfoquinovose(1-) catabolic process&apos; SubClassOf &apos;organic acid catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902776</classIRI>
<classLabel>6-sulfoquinovose(1-) metabolic process</classLabel>
<newAxiom>&apos;6-sulfoquinovose(1-) metabolic process&apos; SubClassOf &apos;organic acid metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_48526</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_48526 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_24531</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_24531 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042420</classIRI>
<classLabel>dopamine catabolic process</classLabel>
<newAxiom>&apos;dopamine catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042417</classIRI>
<classLabel>dopamine metabolic process</classLabel>
<newAxiom>&apos;dopamine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042412</classIRI>
<classLabel>taurine biosynthetic process</classLabel>
<newAxiom>&apos;taurine biosynthetic process&apos; SubClassOf &apos;organic acid biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042442</classIRI>
<classLabel>melatonin catabolic process</classLabel>
<newAxiom>&apos;melatonin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042429</classIRI>
<classLabel>serotonin catabolic process</classLabel>
<newAxiom>&apos;serotonin catabolic process&apos; SubClassOf &apos;neurotransmitter catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042428</classIRI>
<classLabel>serotonin metabolic process</classLabel>
<newAxiom>&apos;serotonin metabolic process&apos; SubClassOf &apos;neurotransmitter metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042427</classIRI>
<classLabel>serotonin biosynthetic process</classLabel>
<newAxiom>&apos;serotonin biosynthetic process&apos; SubClassOf &apos;neurotransmitter biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042426</classIRI>
<classLabel>choline catabolic process</classLabel>
<newAxiom>&apos;choline catabolic process&apos; SubClassOf &apos;neurotransmitter catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042425</classIRI>
<classLabel>choline biosynthetic process</classLabel>
<newAxiom>&apos;choline biosynthetic process&apos; SubClassOf &apos;neurotransmitter biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042457</classIRI>
<classLabel>ethylene catabolic process</classLabel>
<newAxiom>&apos;ethylene catabolic process&apos; SubClassOf &apos;hormone catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042448</classIRI>
<classLabel>progesterone metabolic process</classLabel>
<newAxiom>&apos;progesterone metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_63954</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_63954 SubClassOf http://purl.obolibrary.org/obo/GOCHE_24869</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_63954 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_63933</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_63933 SubClassOf http://purl.obolibrary.org/obo/GOCHE_64909</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_1427</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_1427 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_1438</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_1438 SubClassOf http://purl.obolibrary.org/obo/GOCHE_38231</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042318</classIRI>
<classLabel>penicillin biosynthetic process</classLabel>
<deletedAxiom>&apos;penicillin biosynthetic process&apos; SubClassOf &apos;secondary metabolite biosynthetic process&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042317</classIRI>
<classLabel>penicillin catabolic process</classLabel>
<deletedAxiom>&apos;penicillin catabolic process&apos; SubClassOf &apos;secondary metabolite catabolic process&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042316</classIRI>
<classLabel>penicillin metabolic process</classLabel>
<deletedAxiom>&apos;penicillin metabolic process&apos; SubClassOf &apos;secondary metabolic process&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042366</classIRI>
<classLabel>cobalamin catabolic process</classLabel>
<newAxiom>&apos;cobalamin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
<newAxiom>&apos;cobalamin catabolic process&apos; SubClassOf &apos;cofactor catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042376</classIRI>
<classLabel>phylloquinone catabolic process</classLabel>
<newAxiom>&apos;phylloquinone catabolic process&apos; SubClassOf &apos;vitamin catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042374</classIRI>
<classLabel>phylloquinone metabolic process</classLabel>
<newAxiom>&apos;phylloquinone metabolic process&apos; SubClassOf &apos;vitamin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042372</classIRI>
<classLabel>phylloquinone biosynthetic process</classLabel>
<newAxiom>&apos;phylloquinone biosynthetic process&apos; SubClassOf &apos;vitamin biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042367</classIRI>
<classLabel>biotin catabolic process</classLabel>
<newAxiom>&apos;biotin catabolic process&apos; SubClassOf &apos;coenzyme catabolic process&apos;</newAxiom>
<newAxiom>&apos;biotin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_58092</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_58092 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902951</classIRI>
<classLabel>negative regulation of dendritic spine maintenance</classLabel>
<newAxiom>&apos;negative regulation of dendritic spine maintenance&apos; SubClassOf &apos;negative regulation of synapse organization&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902950</classIRI>
<classLabel>regulation of dendritic spine maintenance</classLabel>
<newAxiom>&apos;regulation of dendritic spine maintenance&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099175</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_58070</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_58070 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_58069</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_58069 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_58065</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_58065 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_58057</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_58057 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_58053</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_58053 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_58052</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_58052 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_58040</classIRI>
<deletedAxiom>http://purl.obolibrary.org/obo/CHEBI_58040 SubClassOf http://purl.obolibrary.org/obo/CHEBI_25697</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_58027</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_58027 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_58017</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_58017 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_24797</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_24797 SubClassOf http://purl.obolibrary.org/obo/GOCHE_26115</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_24757</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_24757 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_24757 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032841</classIRI>
<classLabel>calcitonin binding</classLabel>
<newAxiom>&apos;calcitonin binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_10119</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_10119 SubClassOf http://purl.obolibrary.org/obo/GOCHE_52210</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_10119 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35476</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_73688</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_73688 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042201</classIRI>
<classLabel>N-cyclopropylmelamine metabolic process</classLabel>
<newAxiom>&apos;N-cyclopropylmelamine metabolic process&apos; SubClassOf &apos;insecticide metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032882</classIRI>
<classLabel>regulation of chitin metabolic process</classLabel>
<newAxiom>&apos;regulation of chitin metabolic process&apos; SubClassOf &apos;regulation of cellular metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_73693</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_73693 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_73693 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042220</classIRI>
<classLabel>response to cocaine</classLabel>
<newAxiom>&apos;response to cocaine&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
<newAxiom>&apos;response to cocaine&apos; SubClassOf &apos;response to anesthetic&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042216</classIRI>
<classLabel>phenanthrene catabolic process</classLabel>
<newAxiom>&apos;phenanthrene catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042203</classIRI>
<classLabel>toluene catabolic process</classLabel>
<newAxiom>&apos;toluene catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042202</classIRI>
<classLabel>N-cyclopropylmelamine catabolic process</classLabel>
<newAxiom>&apos;N-cyclopropylmelamine catabolic process&apos; SubClassOf &apos;insecticide catabolic process&apos;</newAxiom>
<newAxiom>&apos;N-cyclopropylmelamine catabolic process&apos; SubClassOf &apos;detoxification of nitrogen compound&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042166</classIRI>
<classLabel>acetylcholine binding</classLabel>
<newAxiom>&apos;acetylcholine binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
<newAxiom>&apos;acetylcholine binding&apos; SubClassOf &apos;hormone binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042188</classIRI>
<classLabel>1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolic process</classLabel>
<newAxiom>&apos;1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042183</classIRI>
<classLabel>formate catabolic process</classLabel>
<newAxiom>&apos;formate catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_136912</classIRI>
<deletedAxiom>http://purl.obolibrary.org/obo/CHEBI_136912 SubClassOf http://purl.obolibrary.org/obo/CHEBI_37739</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_136913</classIRI>
<deletedAxiom>http://purl.obolibrary.org/obo/CHEBI_136913 SubClassOf http://purl.obolibrary.org/obo/CHEBI_37739</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042190</classIRI>
<classLabel>vanillin catabolic process</classLabel>
<newAxiom>&apos;vanillin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_48635</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_48635 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23924</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0017107</classIRI>
<classLabel>anion exchanger adaptor activity</classLabel>
<deletedAxiom>&apos;anion exchanger adaptor activity&apos; SubClassOf &apos;protein binding, bridging&apos;</deletedAxiom>
<newAxiom>&apos;anion exchanger adaptor activity&apos; SubClassOf http://www.w3.org/2002/07/owl#Thing</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_10003</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_10003 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_10003 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032782</classIRI>
<classLabel>bile acid secretion</classLabel>
<deletedAxiom>&apos;bile acid secretion&apos; SubClassOf &apos;bile acid and bile salt transport&apos;</deletedAxiom>
<newAxiom>&apos;bile acid secretion&apos; SubClassOf &apos;monocarboxylic acid transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042122</classIRI>
<classLabel>alginic acid catabolic process</classLabel>
<newAxiom>&apos;alginic acid catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042120</classIRI>
<classLabel>alginic acid metabolic process</classLabel>
<newAxiom>&apos;alginic acid metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_48080</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_48080 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_48041</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_48041 SubClassOf http://purl.obolibrary.org/obo/GOCHE_27026</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_24061</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_24061 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33284</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_24040</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_24040 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23357</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_24041</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_24041 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23357</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_63624</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_63624 SubClassOf http://purl.obolibrary.org/obo/GOCHE_59897</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_63624 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_38656</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_38656 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25944</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0017001</classIRI>
<classLabel>antibiotic catabolic process</classLabel>
<deletedAxiom>&apos;antibiotic catabolic process&apos; SubClassOf &apos;cellular catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;antibiotic catabolic process&apos; SubClassOf &apos;toxin catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0017000</classIRI>
<classLabel>antibiotic biosynthetic process</classLabel>
<deletedAxiom>&apos;antibiotic biosynthetic process&apos; SubClassOf &apos;cellular biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;antibiotic biosynthetic process&apos; SubClassOf &apos;toxin biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_87632</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_87632 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_87631</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_87631 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35664</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_63580</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_63580 SubClassOf http://purl.obolibrary.org/obo/GOCHE_35221</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_63580 SubClassOf http://purl.obolibrary.org/obo/GOCHE_59897</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_63580 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_63528</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_63528 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_38579</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_38579 SubClassOf http://purl.obolibrary.org/obo/GOCHE_26013</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_533015</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_533015 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032500</classIRI>
<classLabel>muramyl dipeptide binding</classLabel>
<newAxiom>&apos;muramyl dipeptide binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032570</classIRI>
<classLabel>response to progesterone</classLabel>
<newAxiom>&apos;response to progesterone&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032573</classIRI>
<classLabel>response to phylloquinone</classLabel>
<newAxiom>&apos;response to phylloquinone&apos; SubClassOf &apos;response to vitamin&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032495</classIRI>
<classLabel>response to muramyl dipeptide</classLabel>
<newAxiom>&apos;response to muramyl dipeptide&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_24298</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_24298 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_24279</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_24279 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_24250</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_24250 SubClassOf http://purl.obolibrary.org/obo/GOCHE_37848</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_24229</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_24229 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_24229 SubClassOf http://purl.obolibrary.org/obo/GOCHE_33281</newAxiom>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_24229 SubClassOf http://purl.obolibrary.org/obo/GOCHE_23888</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032361</classIRI>
<classLabel>pyridoxal phosphate catabolic process</classLabel>
<deletedAxiom>&apos;pyridoxal phosphate catabolic process&apos; SubClassOf &apos;cofactor catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;pyridoxal phosphate catabolic process&apos; SubClassOf &apos;coenzyme catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032355</classIRI>
<classLabel>response to estradiol</classLabel>
<newAxiom>&apos;response to estradiol&apos; SubClassOf &apos;response to hormone&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071934</classIRI>
<classLabel>thiamine transmembrane transport</classLabel>
<newAxiom>&apos;thiamine transmembrane transport&apos; SubClassOf &apos;vitamin transmembrane transport&apos;</newAxiom>
<newAxiom>&apos;thiamine transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071939</classIRI>
<classLabel>vitamin A import</classLabel>
<newAxiom>&apos;vitamin A import&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071938</classIRI>
<classLabel>vitamin A transport</classLabel>
<newAxiom>&apos;vitamin A transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_48120</classIRI>
<newAxiom>http://purl.obolibrary.org/obo/CHEBI_48120 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/CHEBI_48132</classIRI>
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<newAxiom>http://purl.obolibrary.org/obo/CHEBI_48132 SubClassOf http://purl.obolibrary.org/obo/GOCHE_25212</newAxiom>
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