<?xml version="1.0"?>
<diffReport>
<diffSummary>
<numberChangedClasses>
1105
</numberChangedClasses>
<numberNewClasses>
9
</numberNewClasses>
<numberDeletedClasses>
0
</numberDeletedClasses>
</diffSummary>
<changedClasses>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019262</classIRI>
<classLabel>N-acetylneuraminate catabolic process</classLabel>
<newAxiom>&apos;N-acetylneuraminate catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032238</classIRI>
<classLabel>adenosine transport</classLabel>
<newAxiom>&apos;adenosine transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019260</classIRI>
<classLabel>1,2-dichloroethane catabolic process</classLabel>
<deletedAxiom>&apos;1,2-dichloroethane catabolic process&apos; SubClassOf &apos;chlorinated hydrocarbon catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;1,2-dichloroethane catabolic process&apos; SubClassOf &apos;organic substance catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019261</classIRI>
<classLabel>1,4-dichlorobenzene catabolic process</classLabel>
<newAxiom>&apos;1,4-dichlorobenzene catabolic process&apos; SubClassOf &apos;insecticide catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046874</classIRI>
<classLabel>quinolinate metabolic process</classLabel>
<newAxiom>&apos;quinolinate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019270</classIRI>
<classLabel>aerobactin biosynthetic process</classLabel>
<newAxiom>&apos;aerobactin biosynthetic process&apos; SubClassOf &apos;cofactor biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019271</classIRI>
<classLabel>aerobactin transport</classLabel>
<newAxiom>&apos;aerobactin transport&apos; SubClassOf &apos;siderophore transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019295</classIRI>
<classLabel>coenzyme M biosynthetic process</classLabel>
<deletedAxiom>&apos;coenzyme M biosynthetic process&apos; SubClassOf &apos;organic substance biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;coenzyme M biosynthetic process&apos; SubClassOf &apos;organic acid biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019296</classIRI>
<classLabel>coenzyme M metabolic process</classLabel>
<deletedAxiom>&apos;coenzyme M metabolic process&apos; SubClassOf &apos;organic substance metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;coenzyme M metabolic process&apos; SubClassOf &apos;organic acid metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046898</classIRI>
<classLabel>response to cycloheximide</classLabel>
<newAxiom>&apos;response to cycloheximide&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
<newAxiom>&apos;response to cycloheximide&apos; SubClassOf &apos;response to fungicide&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032249</classIRI>
<classLabel>regulation of adenosine transport</classLabel>
<newAxiom>&apos;regulation of adenosine transport&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032251</classIRI>
<classLabel>positive regulation of adenosine transport</classLabel>
<newAxiom>&apos;positive regulation of adenosine transport&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032250</classIRI>
<classLabel>negative regulation of adenosine transport</classLabel>
<newAxiom>&apos;negative regulation of adenosine transport&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071886</classIRI>
<classLabel>1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding</classLabel>
<newAxiom>&apos;1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0140009</classIRI>
<classLabel>L-aspartate import across plasma membrane</classLabel>
<newAxiom>&apos;L-aspartate import across plasma membrane&apos; SubClassOf &apos;neurotransmitter uptake&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010816</classIRI>
<classLabel>calcitonin catabolic process</classLabel>
<newAxiom>&apos;calcitonin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010815</classIRI>
<classLabel>bradykinin catabolic process</classLabel>
<newAxiom>&apos;bradykinin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032217</classIRI>
<classLabel>riboflavin transmembrane transporter activity</classLabel>
<newAxiom>&apos;riboflavin transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032218</classIRI>
<classLabel>riboflavin transport</classLabel>
<newAxiom>&apos;riboflavin transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019182</classIRI>
<classLabel>histamine-gated chloride channel activity</classLabel>
<newAxiom>&apos;histamine-gated chloride channel activity&apos; SubClassOf &apos;ligand-gated anion channel activity&apos;</newAxiom>
<newAxiom>&apos;histamine-gated chloride channel activity&apos; SubClassOf &apos;transmitter-gated channel activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019183</classIRI>
<classLabel>histamine-gated chloride channel complex</classLabel>
<deletedAxiom>&apos;histamine-gated chloride channel complex&apos; SubClassOf &apos;plasma membrane part&apos;</deletedAxiom>
<newAxiom>&apos;histamine-gated chloride channel complex&apos; SubClassOf &apos;neurotransmitter receptor complex&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071731</classIRI>
<classLabel>response to nitric oxide</classLabel>
<newAxiom>&apos;response to nitric oxide&apos; SubClassOf &apos;response to bronchodilator&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071732</classIRI>
<classLabel>cellular response to nitric oxide</classLabel>
<newAxiom>&apos;cellular response to nitric oxide&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010726</classIRI>
<classLabel>positive regulation of hydrogen peroxide metabolic process</classLabel>
<newAxiom>&apos;positive regulation of hydrogen peroxide metabolic process&apos; SubClassOf &apos;positive regulation of cofactor metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010727</classIRI>
<classLabel>negative regulation of hydrogen peroxide metabolic process</classLabel>
<newAxiom>&apos;negative regulation of hydrogen peroxide metabolic process&apos; SubClassOf &apos;negative regulation of cofactor metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009751</classIRI>
<classLabel>response to salicylic acid</classLabel>
<newAxiom>&apos;response to salicylic acid&apos; SubClassOf &apos;response to hormone&apos;</newAxiom>
<newAxiom>&apos;response to salicylic acid&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046713</classIRI>
<classLabel>borate transport</classLabel>
<newAxiom>&apos;borate transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046715</classIRI>
<classLabel>active borate transmembrane transporter activity</classLabel>
<newAxiom>&apos;active borate transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046714</classIRI>
<classLabel>borate binding</classLabel>
<newAxiom>&apos;borate binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0034650</classIRI>
<classLabel>cortisol metabolic process</classLabel>
<newAxiom>&apos;cortisol metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046657</classIRI>
<classLabel>folic acid catabolic process</classLabel>
<newAxiom>&apos;folic acid catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046655</classIRI>
<classLabel>folic acid metabolic process</classLabel>
<newAxiom>&apos;folic acid metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0020037</classIRI>
<classLabel>heme binding</classLabel>
<newAxiom>&apos;heme binding&apos; SubClassOf &apos;cofactor binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046680</classIRI>
<classLabel>response to DDT</classLabel>
<newAxiom>&apos;response to DDT&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046679</classIRI>
<classLabel>response to streptomycin</classLabel>
<newAxiom>&apos;response to streptomycin&apos; SubClassOf &apos;response to fungicide&apos;</newAxiom>
<newAxiom>&apos;response to streptomycin&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046677</classIRI>
<classLabel>response to antibiotic</classLabel>
<deletedAxiom>&apos;response to antibiotic&apos; SubClassOf &apos;response to chemical&apos;</deletedAxiom>
<newAxiom>&apos;response to antibiotic&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0034697</classIRI>
<classLabel>response to prostaglandin I</classLabel>
<newAxiom>&apos;response to prostaglandin I&apos; SubClassOf &apos;response to organic cyclic compound&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032052</classIRI>
<classLabel>bile acid binding</classLabel>
<deletedAxiom>&apos;bile acid binding&apos; SubClassOf &apos;steroid binding&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071681</classIRI>
<classLabel>cellular response to indole-3-methanol</classLabel>
<newAxiom>&apos;cellular response to indole-3-methanol&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071680</classIRI>
<classLabel>response to indole-3-methanol</classLabel>
<newAxiom>&apos;response to indole-3-methanol&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0034617</classIRI>
<classLabel>tetrahydrobiopterin binding</classLabel>
<newAxiom>&apos;tetrahydrobiopterin binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0034634</classIRI>
<classLabel>glutathione transmembrane transporter activity</classLabel>
<newAxiom>&apos;glutathione transmembrane transporter activity&apos; SubClassOf &apos;cofactor transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0034635</classIRI>
<classLabel>glutathione transport</classLabel>
<newAxiom>&apos;glutathione transport&apos; SubClassOf &apos;cofactor transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009685</classIRI>
<classLabel>gibberellin metabolic process</classLabel>
<newAxiom>&apos;gibberellin metabolic process&apos; SubClassOf &apos;hormone metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009686</classIRI>
<classLabel>gibberellin biosynthetic process</classLabel>
<newAxiom>&apos;gibberellin biosynthetic process&apos; SubClassOf &apos;hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009694</classIRI>
<classLabel>jasmonic acid metabolic process</classLabel>
<newAxiom>&apos;jasmonic acid metabolic process&apos; SubClassOf &apos;hormone metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009695</classIRI>
<classLabel>jasmonic acid biosynthetic process</classLabel>
<newAxiom>&apos;jasmonic acid biosynthetic process&apos; SubClassOf &apos;hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009692</classIRI>
<classLabel>ethylene metabolic process</classLabel>
<newAxiom>&apos;ethylene metabolic process&apos; SubClassOf &apos;hormone metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009693</classIRI>
<classLabel>ethylene biosynthetic process</classLabel>
<newAxiom>&apos;ethylene biosynthetic process&apos; SubClassOf &apos;hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009696</classIRI>
<classLabel>salicylic acid metabolic process</classLabel>
<newAxiom>&apos;salicylic acid metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
<newAxiom>&apos;salicylic acid metabolic process&apos; SubClassOf &apos;hormone metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009697</classIRI>
<classLabel>salicylic acid biosynthetic process</classLabel>
<newAxiom>&apos;salicylic acid biosynthetic process&apos; SubClassOf &apos;hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046584</classIRI>
<classLabel>enniatin metabolic process</classLabel>
<newAxiom>&apos;enniatin metabolic process&apos; SubClassOf &apos;mycotoxin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046585</classIRI>
<classLabel>enniatin biosynthetic process</classLabel>
<newAxiom>&apos;enniatin biosynthetic process&apos; SubClassOf &apos;mycotoxin biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071504</classIRI>
<classLabel>cellular response to heparin</classLabel>
<newAxiom>&apos;cellular response to heparin&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071503</classIRI>
<classLabel>response to heparin</classLabel>
<newAxiom>&apos;response to heparin&apos; SubClassOf &apos;response to anticoagulant&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071506</classIRI>
<classLabel>cellular response to mycophenolic acid</classLabel>
<newAxiom>&apos;cellular response to mycophenolic acid&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to mycophenolic acid&apos; SubClassOf &apos;cellular response to mycotoxin&apos;</newAxiom>
<newAxiom>&apos;cellular response to mycophenolic acid&apos; SubClassOf &apos;cellular response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071505</classIRI>
<classLabel>response to mycophenolic acid</classLabel>
<newAxiom>&apos;response to mycophenolic acid&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
<newAxiom>&apos;response to mycophenolic acid&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
<newAxiom>&apos;response to mycophenolic acid&apos; SubClassOf &apos;response to mycotoxin&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071548</classIRI>
<classLabel>response to dexamethasone</classLabel>
<newAxiom>&apos;response to dexamethasone&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
<newAxiom>&apos;response to dexamethasone&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071549</classIRI>
<classLabel>cellular response to dexamethasone stimulus</classLabel>
<newAxiom>&apos;cellular response to dexamethasone stimulus&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to dexamethasone stimulus&apos; SubClassOf &apos;cellular response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046500</classIRI>
<classLabel>S-adenosylmethionine metabolic process</classLabel>
<newAxiom>&apos;S-adenosylmethionine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0034516</classIRI>
<classLabel>response to vitamin B6</classLabel>
<newAxiom>&apos;response to vitamin B6&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046440</classIRI>
<classLabel>L-lysine metabolic process</classLabel>
<newAxiom>&apos;L-lysine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046442</classIRI>
<classLabel>aerobactin metabolic process</classLabel>
<newAxiom>&apos;aerobactin metabolic process&apos; SubClassOf &apos;siderophore metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071409</classIRI>
<classLabel>cellular response to cycloheximide</classLabel>
<newAxiom>&apos;cellular response to cycloheximide&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
<newAxiom>&apos;cellular response to cycloheximide&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0034465</classIRI>
<classLabel>response to carbon monoxide</classLabel>
<newAxiom>&apos;response to carbon monoxide&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
<newAxiom>&apos;response to carbon monoxide&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046469</classIRI>
<classLabel>platelet activating factor metabolic process</classLabel>
<newAxiom>&apos;platelet activating factor metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071446</classIRI>
<classLabel>cellular response to salicylic acid stimulus</classLabel>
<newAxiom>&apos;cellular response to salicylic acid stimulus&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to salicylic acid stimulus&apos; SubClassOf &apos;cellular response to hormone stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071422</classIRI>
<classLabel>succinate transmembrane transport</classLabel>
<newAxiom>&apos;succinate transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046498</classIRI>
<classLabel>S-adenosylhomocysteine metabolic process</classLabel>
<newAxiom>&apos;S-adenosylhomocysteine metabolic process&apos; SubClassOf &apos;cofactor metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071412</classIRI>
<classLabel>cellular response to genistein</classLabel>
<newAxiom>&apos;cellular response to genistein&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to genistein&apos; SubClassOf &apos;cellular response to hormone stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071411</classIRI>
<classLabel>cellular response to fluoxetine</classLabel>
<newAxiom>&apos;cellular response to fluoxetine&apos; SubClassOf &apos;cellular response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071414</classIRI>
<classLabel>cellular response to methotrexate</classLabel>
<newAxiom>&apos;cellular response to methotrexate&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071419</classIRI>
<classLabel>cellular response to amphetamine</classLabel>
<newAxiom>&apos;cellular response to amphetamine&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to amphetamine&apos; SubClassOf &apos;cellular response to xenobiotic stimulus&apos;</newAxiom>
<newAxiom>&apos;cellular response to amphetamine&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071452</classIRI>
<classLabel>cellular response to singlet oxygen</classLabel>
<newAxiom>&apos;cellular response to singlet oxygen&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to singlet oxygen&apos; SubClassOf &apos;cellular response to nutrient&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071457</classIRI>
<classLabel>cellular response to ozone</classLabel>
<newAxiom>&apos;cellular response to ozone&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071387</classIRI>
<classLabel>cellular response to cortisol stimulus</classLabel>
<newAxiom>&apos;cellular response to cortisol stimulus&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071390</classIRI>
<classLabel>cellular response to ecdysone</classLabel>
<newAxiom>&apos;cellular response to ecdysone&apos; SubClassOf &apos;cellular response to hormone stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071393</classIRI>
<classLabel>cellular response to progesterone stimulus</classLabel>
<newAxiom>&apos;cellular response to progesterone stimulus&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071392</classIRI>
<classLabel>cellular response to estradiol stimulus</classLabel>
<newAxiom>&apos;cellular response to estradiol stimulus&apos; SubClassOf &apos;cellular response to hormone stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071394</classIRI>
<classLabel>cellular response to testosterone stimulus</classLabel>
<newAxiom>&apos;cellular response to testosterone stimulus&apos; SubClassOf &apos;cellular response to hormone stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071382</classIRI>
<classLabel>cellular response to prostaglandin I stimulus</classLabel>
<newAxiom>&apos;cellular response to prostaglandin I stimulus&apos; SubClassOf &apos;cellular response to organic cyclic compound&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009441</classIRI>
<classLabel>glycolate metabolic process</classLabel>
<newAxiom>&apos;glycolate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009449</classIRI>
<classLabel>gamma-aminobutyric acid biosynthetic process</classLabel>
<newAxiom>&apos;gamma-aminobutyric acid biosynthetic process&apos; SubClassOf &apos;neurotransmitter biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009448</classIRI>
<classLabel>gamma-aminobutyric acid metabolic process</classLabel>
<newAxiom>&apos;gamma-aminobutyric acid metabolic process&apos; SubClassOf &apos;neurotransmitter metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009450</classIRI>
<classLabel>gamma-aminobutyric acid catabolic process</classLabel>
<newAxiom>&apos;gamma-aminobutyric acid catabolic process&apos; SubClassOf &apos;neurotransmitter catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010337</classIRI>
<classLabel>regulation of salicylic acid metabolic process</classLabel>
<newAxiom>&apos;regulation of salicylic acid metabolic process&apos; SubClassOf &apos;regulation of hormone metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046300</classIRI>
<classLabel>2,4-dichlorophenoxyacetic acid catabolic process</classLabel>
<newAxiom>&apos;2,4-dichlorophenoxyacetic acid catabolic process&apos; SubClassOf &apos;xenobiotic catabolic process&apos;</newAxiom>
<newAxiom>&apos;2,4-dichlorophenoxyacetic acid catabolic process&apos; SubClassOf &apos;auxin catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046302</classIRI>
<classLabel>2-chloro-N-isopropylacetanilide catabolic process</classLabel>
<newAxiom>&apos;2-chloro-N-isopropylacetanilide catabolic process&apos; SubClassOf &apos;xenobiotic catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046304</classIRI>
<classLabel>2-nitropropane catabolic process</classLabel>
<newAxiom>&apos;2-nitropropane catabolic process&apos; SubClassOf &apos;organic substance catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010364</classIRI>
<classLabel>regulation of ethylene biosynthetic process</classLabel>
<deletedAxiom>&apos;regulation of ethylene biosynthetic process&apos; SubClassOf &apos;regulation of cellular biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;regulation of ethylene biosynthetic process&apos; SubClassOf &apos;regulation of hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010365</classIRI>
<classLabel>positive regulation of ethylene biosynthetic process</classLabel>
<deletedAxiom>&apos;positive regulation of ethylene biosynthetic process&apos; SubClassOf &apos;positive regulation of cellular biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;positive regulation of ethylene biosynthetic process&apos; SubClassOf &apos;positive regulation of hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010366</classIRI>
<classLabel>negative regulation of ethylene biosynthetic process</classLabel>
<deletedAxiom>&apos;negative regulation of ethylene biosynthetic process&apos; SubClassOf &apos;negative regulation of cellular biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of ethylene biosynthetic process&apos; SubClassOf &apos;negative regulation of hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009374</classIRI>
<classLabel>biotin binding</classLabel>
<newAxiom>&apos;biotin binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
<newAxiom>&apos;biotin binding&apos; SubClassOf &apos;coenzyme binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010371</classIRI>
<classLabel>regulation of gibberellin biosynthetic process</classLabel>
<deletedAxiom>&apos;regulation of gibberellin biosynthetic process&apos; SubClassOf &apos;regulation of cellular biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;regulation of gibberellin biosynthetic process&apos; SubClassOf &apos;regulation of hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010372</classIRI>
<classLabel>positive regulation of gibberellin biosynthetic process</classLabel>
<deletedAxiom>&apos;positive regulation of gibberellin biosynthetic process&apos; SubClassOf &apos;positive regulation of cellular biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;positive regulation of gibberellin biosynthetic process&apos; SubClassOf &apos;positive regulation of hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010373</classIRI>
<classLabel>negative regulation of gibberellin biosynthetic process</classLabel>
<deletedAxiom>&apos;negative regulation of gibberellin biosynthetic process&apos; SubClassOf &apos;negative regulation of cellular biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of gibberellin biosynthetic process&apos; SubClassOf &apos;negative regulation of hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0000954</classIRI>
<classLabel>methionine catabolic process to 3-methylthiopropanoate</classLabel>
<newAxiom>&apos;methionine catabolic process to 3-methylthiopropanoate&apos; SubClassOf &apos;toxin biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046343</classIRI>
<classLabel>streptomycin metabolic process</classLabel>
<newAxiom>&apos;streptomycin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010391</classIRI>
<classLabel>glucomannan metabolic process</classLabel>
<newAxiom>&apos;glucomannan metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071323</classIRI>
<classLabel>cellular response to chitin</classLabel>
<newAxiom>&apos;cellular response to chitin&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071313</classIRI>
<classLabel>cellular response to caffeine</classLabel>
<newAxiom>&apos;cellular response to caffeine&apos; SubClassOf &apos;cellular response to xenobiotic stimulus&apos;</newAxiom>
<newAxiom>&apos;cellular response to caffeine&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071315</classIRI>
<classLabel>cellular response to morphine</classLabel>
<newAxiom>&apos;cellular response to morphine&apos; SubClassOf &apos;cellular response to xenobiotic stimulus&apos;</newAxiom>
<newAxiom>&apos;cellular response to morphine&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071314</classIRI>
<classLabel>cellular response to cocaine</classLabel>
<newAxiom>&apos;cellular response to cocaine&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to cocaine&apos; SubClassOf &apos;cellular response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071316</classIRI>
<classLabel>cellular response to nicotine</classLabel>
<deletedAxiom>&apos;cellular response to nicotine&apos; SubClassOf &apos;cellular response to chemical stimulus&apos;</deletedAxiom>
<newAxiom>&apos;cellular response to nicotine&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to nicotine&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071319</classIRI>
<classLabel>cellular response to benzoic acid</classLabel>
<newAxiom>&apos;cellular response to benzoic acid&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071318</classIRI>
<classLabel>cellular response to ATP</classLabel>
<newAxiom>&apos;cellular response to ATP&apos; SubClassOf &apos;cellular response to nutrient&apos;</newAxiom>
<newAxiom>&apos;cellular response to ATP&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071302</classIRI>
<classLabel>cellular response to vitamin B2</classLabel>
<newAxiom>&apos;cellular response to vitamin B2&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071301</classIRI>
<classLabel>cellular response to vitamin B1</classLabel>
<newAxiom>&apos;cellular response to vitamin B1&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071304</classIRI>
<classLabel>cellular response to vitamin B6</classLabel>
<newAxiom>&apos;cellular response to vitamin B6&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071309</classIRI>
<classLabel>cellular response to phylloquinone</classLabel>
<newAxiom>&apos;cellular response to phylloquinone&apos; SubClassOf &apos;cellular response to vitamin&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071361</classIRI>
<classLabel>cellular response to ethanol</classLabel>
<newAxiom>&apos;cellular response to ethanol&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
<newAxiom>&apos;cellular response to ethanol&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071296</classIRI>
<classLabel>cellular response to biotin</classLabel>
<newAxiom>&apos;cellular response to biotin&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071265</classIRI>
<classLabel>L-methionine biosynthetic process</classLabel>
<newAxiom>&apos;L-methionine biosynthetic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071272</classIRI>
<classLabel>morphine metabolic process</classLabel>
<newAxiom>&apos;morphine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
<newAxiom>&apos;morphine metabolic process&apos; SubClassOf &apos;xenobiotic metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071273</classIRI>
<classLabel>morphine catabolic process</classLabel>
<newAxiom>&apos;morphine catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
<newAxiom>&apos;morphine catabolic process&apos; SubClassOf &apos;xenobiotic catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071297</classIRI>
<classLabel>cellular response to cobalamin</classLabel>
<newAxiom>&apos;cellular response to cobalamin&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010310</classIRI>
<classLabel>regulation of hydrogen peroxide metabolic process</classLabel>
<newAxiom>&apos;regulation of hydrogen peroxide metabolic process&apos; SubClassOf &apos;regulation of cofactor metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009232</classIRI>
<classLabel>riboflavin catabolic process</classLabel>
<newAxiom>&apos;riboflavin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009236</classIRI>
<classLabel>cobalamin biosynthetic process</classLabel>
<newAxiom>&apos;cobalamin biosynthetic process&apos; SubClassOf &apos;cofactor biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009235</classIRI>
<classLabel>cobalamin metabolic process</classLabel>
<newAxiom>&apos;cobalamin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
<newAxiom>&apos;cobalamin metabolic process&apos; SubClassOf &apos;cofactor metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010266</classIRI>
<classLabel>response to vitamin B1</classLabel>
<newAxiom>&apos;response to vitamin B1&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0034213</classIRI>
<classLabel>quinolinate catabolic process</classLabel>
<newAxiom>&apos;quinolinate catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0000822</classIRI>
<classLabel>inositol hexakisphosphate binding</classLabel>
<newAxiom>&apos;inositol hexakisphosphate binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046225</classIRI>
<classLabel>bacteriocin catabolic process</classLabel>
<deletedAxiom>&apos;bacteriocin catabolic process&apos; SubClassOf &apos;detoxification of nitrogen compound&apos;</deletedAxiom>
<deletedAxiom>&apos;bacteriocin catabolic process&apos; SubClassOf &apos;toxin catabolic process&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046224</classIRI>
<classLabel>bacteriocin metabolic process</classLabel>
<deletedAxiom>&apos;bacteriocin metabolic process&apos; SubClassOf &apos;toxin metabolic process&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046210</classIRI>
<classLabel>nitric oxide catabolic process</classLabel>
<newAxiom>&apos;nitric oxide catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
<newAxiom>&apos;nitric oxide catabolic process&apos; SubClassOf &apos;neurotransmitter catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046209</classIRI>
<classLabel>nitric oxide metabolic process</classLabel>
<newAxiom>&apos;nitric oxide metabolic process&apos; SubClassOf &apos;neurotransmitter metabolic process&apos;</newAxiom>
<newAxiom>&apos;nitric oxide metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046208</classIRI>
<classLabel>spermine catabolic process</classLabel>
<newAxiom>&apos;spermine catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046244</classIRI>
<classLabel>salicylic acid catabolic process</classLabel>
<newAxiom>&apos;salicylic acid catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
<newAxiom>&apos;salicylic acid catabolic process&apos; SubClassOf &apos;hormone catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046230</classIRI>
<classLabel>2-aminobenzenesulfonate catabolic process</classLabel>
<newAxiom>&apos;2-aminobenzenesulfonate catabolic process&apos; SubClassOf &apos;organic acid catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046228</classIRI>
<classLabel>2,4,5-trichlorophenoxyacetic acid catabolic process</classLabel>
<newAxiom>&apos;2,4,5-trichlorophenoxyacetic acid catabolic process&apos; SubClassOf &apos;auxin catabolic process&apos;</newAxiom>
<newAxiom>&apos;2,4,5-trichlorophenoxyacetic acid catabolic process&apos; SubClassOf &apos;xenobiotic catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046269</classIRI>
<classLabel>toluene-4-sulfonate catabolic process</classLabel>
<deletedAxiom>&apos;toluene-4-sulfonate catabolic process&apos; SubClassOf &apos;small molecule catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;toluene-4-sulfonate catabolic process&apos; SubClassOf &apos;organic acid catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0034275</classIRI>
<classLabel>kynurenic acid metabolic process</classLabel>
<newAxiom>&apos;kynurenic acid metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071245</classIRI>
<classLabel>cellular response to carbon monoxide</classLabel>
<newAxiom>&apos;cellular response to carbon monoxide&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to carbon monoxide&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071244</classIRI>
<classLabel>cellular response to carbon dioxide</classLabel>
<newAxiom>&apos;cellular response to carbon dioxide&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046285</classIRI>
<classLabel>flavonoid phytoalexin metabolic process</classLabel>
<newAxiom>&apos;flavonoid phytoalexin metabolic process&apos; SubClassOf &apos;phytoalexin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071231</classIRI>
<classLabel>cellular response to folic acid</classLabel>
<newAxiom>&apos;cellular response to folic acid&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046278</classIRI>
<classLabel>3,4-dihydroxybenzoate metabolic process</classLabel>
<newAxiom>&apos;3,4-dihydroxybenzoate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071236</classIRI>
<classLabel>cellular response to antibiotic</classLabel>
<deletedAxiom>&apos;cellular response to antibiotic&apos; SubClassOf &apos;cellular response to chemical stimulus&apos;</deletedAxiom>
<newAxiom>&apos;cellular response to antibiotic&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071239</classIRI>
<classLabel>cellular response to streptomycin</classLabel>
<newAxiom>&apos;cellular response to streptomycin&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071225</classIRI>
<classLabel>cellular response to muramyl dipeptide</classLabel>
<newAxiom>&apos;cellular response to muramyl dipeptide&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046296</classIRI>
<classLabel>glycolate catabolic process</classLabel>
<newAxiom>&apos;glycolate catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010200</classIRI>
<classLabel>response to chitin</classLabel>
<newAxiom>&apos;response to chitin&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0009102</classIRI>
<classLabel>biotin biosynthetic process</classLabel>
<newAxiom>&apos;biotin biosynthetic process&apos; SubClassOf &apos;coenzyme biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010124</classIRI>
<classLabel>phenylacetate catabolic process</classLabel>
<newAxiom>&apos;phenylacetate catabolic process&apos; SubClassOf &apos;auxin catabolic process&apos;</newAxiom>
<newAxiom>&apos;phenylacetate catabolic process&apos; SubClassOf &apos;toxin catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010181</classIRI>
<classLabel>FMN binding</classLabel>
<deletedAxiom>&apos;FMN binding&apos; SubClassOf &apos;cofactor binding&apos;</deletedAxiom>
<newAxiom>&apos;FMN binding&apos; SubClassOf &apos;coenzyme binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046146</classIRI>
<classLabel>tetrahydrobiopterin metabolic process</classLabel>
<newAxiom>&apos;tetrahydrobiopterin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046147</classIRI>
<classLabel>tetrahydrobiopterin catabolic process</classLabel>
<newAxiom>&apos;tetrahydrobiopterin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010193</classIRI>
<classLabel>response to ozone</classLabel>
<newAxiom>&apos;response to ozone&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046085</classIRI>
<classLabel>adenosine metabolic process</classLabel>
<newAxiom>&apos;adenosine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010023</classIRI>
<classLabel>proanthocyanidin biosynthetic process</classLabel>
<newAxiom>&apos;proanthocyanidin biosynthetic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010037</classIRI>
<classLabel>response to carbon dioxide</classLabel>
<newAxiom>&apos;response to carbon dioxide&apos; SubClassOf &apos;response to anesthetic&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046034</classIRI>
<classLabel>ATP metabolic process</classLabel>
<newAxiom>&apos;ATP metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046033</classIRI>
<classLabel>AMP metabolic process</classLabel>
<newAxiom>&apos;AMP metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000224</classIRI>
<classLabel>regulation of testosterone biosynthetic process</classLabel>
<newAxiom>&apos;regulation of testosterone biosynthetic process&apos; SubClassOf &apos;regulation of hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000225</classIRI>
<classLabel>negative regulation of testosterone biosynthetic process</classLabel>
<deletedAxiom>&apos;negative regulation of testosterone biosynthetic process&apos; SubClassOf &apos;negative regulation of cellular biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of testosterone biosynthetic process&apos; SubClassOf &apos;negative regulation of hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0061526</classIRI>
<classLabel>acetylcholine secretion</classLabel>
<deletedAxiom>&apos;acetylcholine secretion&apos; SubClassOf &apos;secretion by cell&apos;</deletedAxiom>
<newAxiom>&apos;acetylcholine secretion&apos; SubClassOf &apos;hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0061539</classIRI>
<classLabel>octopamine secretion</classLabel>
<newAxiom>&apos;octopamine secretion&apos; SubClassOf &apos;neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0061545</classIRI>
<classLabel>tyramine secretion</classLabel>
<newAxiom>&apos;tyramine secretion&apos; SubClassOf &apos;neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0061459</classIRI>
<classLabel>L-arginine transmembrane transporter activity</classLabel>
<newAxiom>&apos;L-arginine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0097328</classIRI>
<classLabel>response to carboplatin</classLabel>
<deletedAxiom>&apos;response to carboplatin&apos; SubClassOf &apos;response to chemical&apos;</deletedAxiom>
<newAxiom>&apos;response to carboplatin&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0061370</classIRI>
<classLabel>testosterone biosynthetic process</classLabel>
<newAxiom>&apos;testosterone biosynthetic process&apos; SubClassOf &apos;hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0097330</classIRI>
<classLabel>response to 5-fluoro-2&apos;-deoxyuridine</classLabel>
<newAxiom>&apos;response to 5-fluoro-2&apos;-deoxyuridine&apos; SubClassOf &apos;response to antimetabolite&apos;</newAxiom>
<newAxiom>&apos;response to 5-fluoro-2&apos;-deoxyuridine&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0097331</classIRI>
<classLabel>response to cytarabine</classLabel>
<newAxiom>&apos;response to cytarabine&apos; SubClassOf &apos;response to antimetabolite&apos;</newAxiom>
<newAxiom>&apos;response to cytarabine&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0097333</classIRI>
<classLabel>response to olanzapine</classLabel>
<newAxiom>&apos;response to olanzapine&apos; SubClassOf &apos;response to antipsychotic drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0097334</classIRI>
<classLabel>response to perphenazine</classLabel>
<newAxiom>&apos;response to perphenazine&apos; SubClassOf &apos;response to antipsychotic drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0097335</classIRI>
<classLabel>response to quetiapine</classLabel>
<newAxiom>&apos;response to quetiapine&apos; SubClassOf &apos;response to antipsychotic drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0097336</classIRI>
<classLabel>response to risperidone</classLabel>
<newAxiom>&apos;response to risperidone&apos; SubClassOf &apos;response to antipsychotic drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0097337</classIRI>
<classLabel>response to ziprasidone</classLabel>
<newAxiom>&apos;response to ziprasidone&apos; SubClassOf &apos;response to antipsychotic drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0097338</classIRI>
<classLabel>response to clozapine</classLabel>
<newAxiom>&apos;response to clozapine&apos; SubClassOf &apos;response to antipsychotic drug&apos;</newAxiom>
<newAxiom>&apos;response to clozapine&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0097339</classIRI>
<classLabel>glycolate transmembrane transport</classLabel>
<newAxiom>&apos;glycolate transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0002936</classIRI>
<classLabel>bradykinin biosynthetic process</classLabel>
<newAxiom>&apos;bradykinin biosynthetic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0036321</classIRI>
<classLabel>ghrelin secretion</classLabel>
<newAxiom>&apos;ghrelin secretion&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0051938</classIRI>
<classLabel>L-glutamate import</classLabel>
<newAxiom>&apos;L-glutamate import&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
<newAxiom>&apos;L-glutamate import&apos; SubClassOf &apos;neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0036378</classIRI>
<classLabel>calcitriol biosynthetic process from calciol</classLabel>
<newAxiom>&apos;calcitriol biosynthetic process from calciol&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
<newAxiom>&apos;calcitriol biosynthetic process from calciol&apos; SubClassOf &apos;hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0036288</classIRI>
<classLabel>response to ximelagatran</classLabel>
<newAxiom>&apos;response to ximelagatran&apos; SubClassOf &apos;response to anticoagulant&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0036287</classIRI>
<classLabel>response to iloperidone</classLabel>
<newAxiom>&apos;response to iloperidone&apos; SubClassOf &apos;response to antipsychotic drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0036280</classIRI>
<classLabel>cellular response to L-canavanine</classLabel>
<newAxiom>&apos;cellular response to L-canavanine&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0036271</classIRI>
<classLabel>response to methylphenidate</classLabel>
<newAxiom>&apos;response to methylphenidate&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0036275</classIRI>
<classLabel>response to 5-fluorouracil</classLabel>
<newAxiom>&apos;response to 5-fluorouracil&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
<newAxiom>&apos;response to 5-fluorouracil&apos; SubClassOf &apos;response to antimetabolite&apos;</newAxiom>
<newAxiom>&apos;response to 5-fluorouracil&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0036274</classIRI>
<classLabel>response to lapatinib</classLabel>
<newAxiom>&apos;response to lapatinib&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0036273</classIRI>
<classLabel>response to statin</classLabel>
<newAxiom>&apos;response to statin&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0036272</classIRI>
<classLabel>response to gemcitabine</classLabel>
<newAxiom>&apos;response to gemcitabine&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
<newAxiom>&apos;response to gemcitabine&apos; SubClassOf &apos;response to antimetabolite&apos;</newAxiom>
<newAxiom>&apos;response to gemcitabine&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000331</classIRI>
<classLabel>regulation of terminal button organization</classLabel>
<deletedAxiom>&apos;regulation of terminal button organization&apos; SubClassOf &apos;regulation of synapse organization&apos;</deletedAxiom>
<newAxiom>&apos;regulation of terminal button organization&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099174</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0097247</classIRI>
<classLabel>epigallocatechin 3-gallate binding</classLabel>
<newAxiom>&apos;epigallocatechin 3-gallate binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0097253</classIRI>
<classLabel>beta-hydroxybutyrate transmembrane transporter activity</classLabel>
<newAxiom>&apos;beta-hydroxybutyrate transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0000304</classIRI>
<classLabel>response to singlet oxygen</classLabel>
<newAxiom>&apos;response to singlet oxygen&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
<newAxiom>&apos;response to singlet oxygen&apos; SubClassOf &apos;response to nutrient&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904067</classIRI>
<classLabel>ascr#2 binding</classLabel>
<newAxiom>&apos;ascr#2 binding&apos; SubClassOf &apos;pheromone binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1990054</classIRI>
<classLabel>response to temozolomide</classLabel>
<newAxiom>&apos;response to temozolomide&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0036245</classIRI>
<classLabel>cellular response to menadione</classLabel>
<newAxiom>&apos;cellular response to menadione&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0036241</classIRI>
<classLabel>glutamate catabolic process to 4-hydroxybutyrate</classLabel>
<newAxiom>&apos;glutamate catabolic process to 4-hydroxybutyrate&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0036229</classIRI>
<classLabel>L-glutamine import</classLabel>
<newAxiom>&apos;L-glutamine import&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0036232</classIRI>
<classLabel>L-tyrosine import</classLabel>
<newAxiom>&apos;L-tyrosine import&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0036231</classIRI>
<classLabel>L-threonine import</classLabel>
<newAxiom>&apos;L-threonine import&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0036254</classIRI>
<classLabel>cellular response to amiloride</classLabel>
<newAxiom>&apos;cellular response to amiloride&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0036253</classIRI>
<classLabel>response to amiloride</classLabel>
<newAxiom>&apos;response to amiloride&apos; SubClassOf &apos;response to diuretic&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0036161</classIRI>
<classLabel>calcitonin secretion</classLabel>
<newAxiom>&apos;calcitonin secretion&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0036162</classIRI>
<classLabel>oxytocin secretion</classLabel>
<newAxiom>&apos;oxytocin secretion&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0000297</classIRI>
<classLabel>spermine transmembrane transporter activity</classLabel>
<newAxiom>&apos;spermine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0000296</classIRI>
<classLabel>spermine transport</classLabel>
<newAxiom>&apos;spermine transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0000255</classIRI>
<classLabel>allantoin metabolic process</classLabel>
<newAxiom>&apos;allantoin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0000256</classIRI>
<classLabel>allantoin catabolic process</classLabel>
<newAxiom>&apos;allantoin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0097160</classIRI>
<classLabel>polychlorinated biphenyl binding</classLabel>
<newAxiom>&apos;polychlorinated biphenyl binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904010</classIRI>
<classLabel>response to Aroclor 1254</classLabel>
<deletedAxiom>&apos;response to Aroclor 1254&apos; SubClassOf &apos;response to chemical&apos;</deletedAxiom>
<newAxiom>&apos;response to Aroclor 1254&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904011</classIRI>
<classLabel>cellular response to Aroclor 1254</classLabel>
<deletedAxiom>&apos;cellular response to Aroclor 1254&apos; SubClassOf &apos;cellular response to chemical stimulus&apos;</deletedAxiom>
<newAxiom>&apos;cellular response to Aroclor 1254&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904047</classIRI>
<classLabel>S-adenosyl-L-methionine binding</classLabel>
<newAxiom>&apos;S-adenosyl-L-methionine binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
<newAxiom>&apos;S-adenosyl-L-methionine binding&apos; SubClassOf &apos;coenzyme binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0051724</classIRI>
<classLabel>NAD transmembrane transporter activity</classLabel>
<deletedAxiom>&apos;NAD transmembrane transporter activity&apos; SubClassOf &apos;cofactor transmembrane transporter activity&apos;</deletedAxiom>
<newAxiom>&apos;NAD transmembrane transporter activity&apos; SubClassOf &apos;coenzyme transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0036109</classIRI>
<classLabel>alpha-linolenic acid metabolic process</classLabel>
<newAxiom>&apos;alpha-linolenic acid metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0051740</classIRI>
<classLabel>ethylene binding</classLabel>
<newAxiom>&apos;ethylene binding&apos; SubClassOf &apos;hormone binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0000095</classIRI>
<classLabel>S-adenosyl-L-methionine transmembrane transporter activity</classLabel>
<newAxiom>&apos;S-adenosyl-L-methionine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0036040</classIRI>
<classLabel>curcumin catabolic process</classLabel>
<newAxiom>&apos;curcumin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0061002</classIRI>
<classLabel>negative regulation of dendritic spine morphogenesis</classLabel>
<newAxiom>&apos;negative regulation of dendritic spine morphogenesis&apos; SubClassOf &apos;negative regulation of synapse organization&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0061001</classIRI>
<classLabel>regulation of dendritic spine morphogenesis</classLabel>
<newAxiom>&apos;regulation of dendritic spine morphogenesis&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099175</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0036039</classIRI>
<classLabel>curcumin metabolic process</classLabel>
<newAxiom>&apos;curcumin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0036088</classIRI>
<classLabel>D-serine catabolic process</classLabel>
<newAxiom>&apos;D-serine catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0097054</classIRI>
<classLabel>L-glutamate biosynthetic process</classLabel>
<newAxiom>&apos;L-glutamate biosynthetic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
<newAxiom>&apos;L-glutamate biosynthetic process&apos; SubClassOf &apos;neurotransmitter metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904102</classIRI>
<classLabel>cellular response to acadesine</classLabel>
<newAxiom>&apos;cellular response to acadesine&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904101</classIRI>
<classLabel>response to acadesine</classLabel>
<newAxiom>&apos;response to acadesine&apos; SubClassOf &apos;response to platelet aggregation inhibitor&apos;</newAxiom>
<newAxiom>&apos;response to acadesine&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0097061</classIRI>
<classLabel>dendritic spine organization</classLabel>
<newAxiom>&apos;dendritic spine organization&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099173</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0097068</classIRI>
<classLabel>response to thyroxine</classLabel>
<newAxiom>&apos;response to thyroxine&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0097069</classIRI>
<classLabel>cellular response to thyroxine stimulus</classLabel>
<newAxiom>&apos;cellular response to thyroxine stimulus&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000907</classIRI>
<classLabel>negative regulation of glucomannan catabolic process</classLabel>
<deletedAxiom>&apos;negative regulation of glucomannan catabolic process&apos; SubClassOf &apos;negative regulation of catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of glucomannan catabolic process&apos; SubClassOf &apos;negative regulation of cellular catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0051608</classIRI>
<classLabel>histamine transport</classLabel>
<newAxiom>&apos;histamine transport&apos; SubClassOf &apos;neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0051633</classIRI>
<classLabel>positive regulation of acetylcholine uptake</classLabel>
<newAxiom>&apos;positive regulation of acetylcholine uptake&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
<newAxiom>&apos;positive regulation of acetylcholine uptake&apos; SubClassOf &apos;positive regulation of neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0051632</classIRI>
<classLabel>negative regulation of acetylcholine uptake</classLabel>
<newAxiom>&apos;negative regulation of acetylcholine uptake&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
<newAxiom>&apos;negative regulation of acetylcholine uptake&apos; SubClassOf &apos;negative regulation of neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0051631</classIRI>
<classLabel>regulation of acetylcholine uptake</classLabel>
<newAxiom>&apos;regulation of acetylcholine uptake&apos; SubClassOf &apos;regulation of neurotransmitter transport&apos;</newAxiom>
<newAxiom>&apos;regulation of acetylcholine uptake&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
<newAxiom>&apos;regulation of acetylcholine uptake&apos; SubClassOf &apos;regulation of hormone levels&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0051536</classIRI>
<classLabel>iron-sulfur cluster binding</classLabel>
<newAxiom>&apos;iron-sulfur cluster binding&apos; SubClassOf &apos;cofactor binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0000064</classIRI>
<classLabel>L-ornithine transmembrane transporter activity</classLabel>
<newAxiom>&apos;L-ornithine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0051584</classIRI>
<classLabel>regulation of dopamine uptake involved in synaptic transmission</classLabel>
<newAxiom>&apos;regulation of dopamine uptake involved in synaptic transmission&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0051586</classIRI>
<classLabel>positive regulation of dopamine uptake involved in synaptic transmission</classLabel>
<newAxiom>&apos;positive regulation of dopamine uptake involved in synaptic transmission&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0051585</classIRI>
<classLabel>negative regulation of dopamine uptake involved in synaptic transmission</classLabel>
<newAxiom>&apos;negative regulation of dopamine uptake involved in synaptic transmission&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0051593</classIRI>
<classLabel>response to folic acid</classLabel>
<newAxiom>&apos;response to folic acid&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000884</classIRI>
<classLabel>glucomannan catabolic process</classLabel>
<newAxiom>&apos;glucomannan catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000898</classIRI>
<classLabel>regulation of glucomannan catabolic process</classLabel>
<newAxiom>&apos;regulation of glucomannan catabolic process&apos; SubClassOf &apos;regulation of cellular catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000864</classIRI>
<classLabel>regulation of estradiol secretion</classLabel>
<deletedAxiom>&apos;regulation of estradiol secretion&apos; SubClassOf &apos;regulation of secretion&apos;</deletedAxiom>
<newAxiom>&apos;regulation of estradiol secretion&apos; SubClassOf &apos;regulation of hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000865</classIRI>
<classLabel>negative regulation of estradiol secretion</classLabel>
<deletedAxiom>&apos;negative regulation of estradiol secretion&apos; SubClassOf &apos;negative regulation of secretion&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of estradiol secretion&apos; SubClassOf &apos;negative regulation of hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000868</classIRI>
<classLabel>negative regulation of estrone secretion</classLabel>
<deletedAxiom>&apos;negative regulation of estrone secretion&apos; SubClassOf &apos;negative regulation of secretion&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of estrone secretion&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
<newAxiom>&apos;negative regulation of estrone secretion&apos; SubClassOf &apos;negative regulation of hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000869</classIRI>
<classLabel>positive regulation of estrone secretion</classLabel>
<deletedAxiom>&apos;positive regulation of estrone secretion&apos; SubClassOf &apos;positive regulation of secretion&apos;</deletedAxiom>
<newAxiom>&apos;positive regulation of estrone secretion&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
<newAxiom>&apos;positive regulation of estrone secretion&apos; SubClassOf &apos;positive regulation of hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000866</classIRI>
<classLabel>positive regulation of estradiol secretion</classLabel>
<deletedAxiom>&apos;positive regulation of estradiol secretion&apos; SubClassOf &apos;positive regulation of secretion&apos;</deletedAxiom>
<newAxiom>&apos;positive regulation of estradiol secretion&apos; SubClassOf &apos;positive regulation of hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000867</classIRI>
<classLabel>regulation of estrone secretion</classLabel>
<deletedAxiom>&apos;regulation of estrone secretion&apos; SubClassOf &apos;regulation of secretion&apos;</deletedAxiom>
<newAxiom>&apos;regulation of estrone secretion&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
<newAxiom>&apos;regulation of estrone secretion&apos; SubClassOf &apos;regulation of hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000871</classIRI>
<classLabel>negative regulation of progesterone secretion</classLabel>
<newAxiom>&apos;negative regulation of progesterone secretion&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000872</classIRI>
<classLabel>positive regulation of progesterone secretion</classLabel>
<newAxiom>&apos;positive regulation of progesterone secretion&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000870</classIRI>
<classLabel>regulation of progesterone secretion</classLabel>
<newAxiom>&apos;regulation of progesterone secretion&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0099548</classIRI>
<classLabel>trans-synaptic signaling by nitric oxide</classLabel>
<newAxiom>&apos;trans-synaptic signaling by nitric oxide&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099163</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000842</classIRI>
<classLabel>positive regulation of dehydroepiandrosterone secretion</classLabel>
<deletedAxiom>&apos;positive regulation of dehydroepiandrosterone secretion&apos; SubClassOf &apos;positive regulation of secretion&apos;</deletedAxiom>
<newAxiom>&apos;positive regulation of dehydroepiandrosterone secretion&apos; SubClassOf &apos;positive regulation of hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000843</classIRI>
<classLabel>regulation of testosterone secretion</classLabel>
<deletedAxiom>&apos;regulation of testosterone secretion&apos; SubClassOf &apos;regulation of secretion&apos;</deletedAxiom>
<newAxiom>&apos;regulation of testosterone secretion&apos; SubClassOf &apos;regulation of hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000840</classIRI>
<classLabel>regulation of dehydroepiandrosterone secretion</classLabel>
<deletedAxiom>&apos;regulation of dehydroepiandrosterone secretion&apos; SubClassOf &apos;regulation of secretion&apos;</deletedAxiom>
<newAxiom>&apos;regulation of dehydroepiandrosterone secretion&apos; SubClassOf &apos;regulation of hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000841</classIRI>
<classLabel>negative regulation of dehydroepiandrosterone secretion</classLabel>
<deletedAxiom>&apos;negative regulation of dehydroepiandrosterone secretion&apos; SubClassOf &apos;negative regulation of secretion&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of dehydroepiandrosterone secretion&apos; SubClassOf &apos;negative regulation of hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000844</classIRI>
<classLabel>negative regulation of testosterone secretion</classLabel>
<deletedAxiom>&apos;negative regulation of testosterone secretion&apos; SubClassOf &apos;negative regulation of secretion&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of testosterone secretion&apos; SubClassOf &apos;negative regulation of hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000845</classIRI>
<classLabel>positive regulation of testosterone secretion</classLabel>
<deletedAxiom>&apos;positive regulation of testosterone secretion&apos; SubClassOf &apos;positive regulation of secretion&apos;</deletedAxiom>
<newAxiom>&apos;positive regulation of testosterone secretion&apos; SubClassOf &apos;positive regulation of hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000839</classIRI>
<classLabel>positive regulation of androstenedione secretion</classLabel>
<deletedAxiom>&apos;positive regulation of androstenedione secretion&apos; SubClassOf &apos;positive regulation of secretion&apos;</deletedAxiom>
<newAxiom>&apos;positive regulation of androstenedione secretion&apos; SubClassOf &apos;positive regulation of hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000837</classIRI>
<classLabel>regulation of androstenedione secretion</classLabel>
<deletedAxiom>&apos;regulation of androstenedione secretion&apos; SubClassOf &apos;regulation of secretion&apos;</deletedAxiom>
<newAxiom>&apos;regulation of androstenedione secretion&apos; SubClassOf &apos;regulation of hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000838</classIRI>
<classLabel>negative regulation of androstenedione secretion</classLabel>
<deletedAxiom>&apos;negative regulation of androstenedione secretion&apos; SubClassOf &apos;negative regulation of secretion&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of androstenedione secretion&apos; SubClassOf &apos;negative regulation of hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0051414</classIRI>
<classLabel>response to cortisol</classLabel>
<newAxiom>&apos;response to cortisol&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0051424</classIRI>
<classLabel>corticotropin-releasing hormone binding</classLabel>
<newAxiom>&apos;corticotropin-releasing hormone binding&apos; SubClassOf &apos;neurotransmitter binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904322</classIRI>
<classLabel>cellular response to forskolin</classLabel>
<newAxiom>&apos;cellular response to forskolin&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904321</classIRI>
<classLabel>response to forskolin</classLabel>
<newAxiom>&apos;response to forskolin&apos; SubClassOf &apos;response to platelet aggregation inhibitor&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904308</classIRI>
<classLabel>cellular response to desipramine</classLabel>
<newAxiom>&apos;cellular response to desipramine&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904307</classIRI>
<classLabel>response to desipramine</classLabel>
<newAxiom>&apos;response to desipramine&apos; SubClassOf &apos;response to antidepressant&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0051463</classIRI>
<classLabel>negative regulation of cortisol secretion</classLabel>
<newAxiom>&apos;negative regulation of cortisol secretion&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0051462</classIRI>
<classLabel>regulation of cortisol secretion</classLabel>
<newAxiom>&apos;regulation of cortisol secretion&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904309</classIRI>
<classLabel>response to cordycepin</classLabel>
<newAxiom>&apos;response to cordycepin&apos; SubClassOf &apos;response to antimetabolite&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0051465</classIRI>
<classLabel>negative regulation of corticotropin-releasing hormone secretion</classLabel>
<newAxiom>&apos;negative regulation of corticotropin-releasing hormone secretion&apos; SubClassOf &apos;negative regulation of neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0051464</classIRI>
<classLabel>positive regulation of cortisol secretion</classLabel>
<newAxiom>&apos;positive regulation of cortisol secretion&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0051466</classIRI>
<classLabel>positive regulation of corticotropin-releasing hormone secretion</classLabel>
<newAxiom>&apos;positive regulation of corticotropin-releasing hormone secretion&apos; SubClassOf &apos;positive regulation of neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904317</classIRI>
<classLabel>cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine</classLabel>
<newAxiom>&apos;cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904316</classIRI>
<classLabel>response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine</classLabel>
<newAxiom>&apos;response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904362</classIRI>
<classLabel>regulation of calcitonin secretion</classLabel>
<newAxiom>&apos;regulation of calcitonin secretion&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904364</classIRI>
<classLabel>positive regulation of calcitonin secretion</classLabel>
<newAxiom>&apos;positive regulation of calcitonin secretion&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904363</classIRI>
<classLabel>negative regulation of calcitonin secretion</classLabel>
<newAxiom>&apos;negative regulation of calcitonin secretion&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904373</classIRI>
<classLabel>response to kainic acid</classLabel>
<newAxiom>&apos;response to kainic acid&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904374</classIRI>
<classLabel>cellular response to kainic acid</classLabel>
<newAxiom>&apos;cellular response to kainic acid&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0002392</classIRI>
<classLabel>platelet activating factor secretion</classLabel>
<newAxiom>&apos;platelet activating factor secretion&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905735</classIRI>
<classLabel>regulation of L-proline import across plasma membrane</classLabel>
<newAxiom>&apos;regulation of L-proline import across plasma membrane&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905736</classIRI>
<classLabel>negative regulation of L-proline import across plasma membrane</classLabel>
<newAxiom>&apos;negative regulation of L-proline import across plasma membrane&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905737</classIRI>
<classLabel>positive regulation of L-proline import across plasma membrane</classLabel>
<newAxiom>&apos;positive regulation of L-proline import across plasma membrane&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903165</classIRI>
<classLabel>response to polycyclic arene</classLabel>
<newAxiom>&apos;response to polycyclic arene&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903166</classIRI>
<classLabel>cellular response to polycyclic arene</classLabel>
<newAxiom>&apos;cellular response to polycyclic arene&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0051378</classIRI>
<classLabel>serotonin binding</classLabel>
<newAxiom>&apos;serotonin binding&apos; SubClassOf &apos;neurotransmitter binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905794</classIRI>
<classLabel>response to puromycin</classLabel>
<newAxiom>&apos;response to puromycin&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905795</classIRI>
<classLabel>cellular response to puromycin</classLabel>
<newAxiom>&apos;cellular response to puromycin&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0051381</classIRI>
<classLabel>histamine binding</classLabel>
<newAxiom>&apos;histamine binding&apos; SubClassOf &apos;neurotransmitter binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903184</classIRI>
<classLabel>L-dopa metabolic process</classLabel>
<newAxiom>&apos;L-dopa metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0004965</classIRI>
<classLabel>G-protein coupled GABA receptor activity</classLabel>
<deletedAxiom>&apos;G-protein coupled GABA receptor activity&apos; SubClassOf &apos;G-protein coupled receptor activity&apos;</deletedAxiom>
<newAxiom>&apos;G-protein coupled GABA receptor activity&apos; SubClassOf &apos;G-protein coupled neurotransmitter receptor activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0004969</classIRI>
<classLabel>histamine receptor activity</classLabel>
<newAxiom>&apos;histamine receptor activity&apos; SubClassOf &apos;G-protein coupled neurotransmitter receptor activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0004979</classIRI>
<classLabel>beta-endorphin receptor activity</classLabel>
<newAxiom>&apos;beta-endorphin receptor activity&apos; SubClassOf &apos;G-protein coupled neurotransmitter receptor activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0004989</classIRI>
<classLabel>octopamine receptor activity</classLabel>
<newAxiom>&apos;octopamine receptor activity&apos; SubClassOf &apos;G-protein coupled neurotransmitter receptor activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0004993</classIRI>
<classLabel>G-protein coupled serotonin receptor activity</classLabel>
<newAxiom>&apos;G-protein coupled serotonin receptor activity&apos; SubClassOf &apos;G-protein coupled neurotransmitter receptor activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0016999</classIRI>
<classLabel>antibiotic metabolic process</classLabel>
<newAxiom>&apos;antibiotic metabolic process&apos; SubClassOf &apos;toxin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905922</classIRI>
<classLabel>negative regulation of acetylcholine biosynthetic process</classLabel>
<deletedAxiom>&apos;negative regulation of acetylcholine biosynthetic process&apos; SubClassOf &apos;negative regulation of cellular biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of acetylcholine biosynthetic process&apos; SubClassOf &apos;negative regulation of hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905923</classIRI>
<classLabel>positive regulation of acetylcholine biosynthetic process</classLabel>
<deletedAxiom>&apos;positive regulation of acetylcholine biosynthetic process&apos; SubClassOf &apos;positive regulation of cellular biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;positive regulation of acetylcholine biosynthetic process&apos; SubClassOf &apos;positive regulation of hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905921</classIRI>
<classLabel>regulation of acetylcholine biosynthetic process</classLabel>
<deletedAxiom>&apos;regulation of acetylcholine biosynthetic process&apos; SubClassOf &apos;regulation of cellular biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;regulation of acetylcholine biosynthetic process&apos; SubClassOf &apos;regulation of hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903206</classIRI>
<classLabel>negative regulation of hydrogen peroxide-induced cell death</classLabel>
<newAxiom>&apos;negative regulation of hydrogen peroxide-induced cell death&apos; SubClassOf &apos;negative regulation of cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903205</classIRI>
<classLabel>regulation of hydrogen peroxide-induced cell death</classLabel>
<newAxiom>&apos;regulation of hydrogen peroxide-induced cell death&apos; SubClassOf &apos;regulation of cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905841</classIRI>
<classLabel>response to oxidopamine</classLabel>
<newAxiom>&apos;response to oxidopamine&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905842</classIRI>
<classLabel>cellular response to oxidopamine</classLabel>
<newAxiom>&apos;cellular response to oxidopamine&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903222</classIRI>
<classLabel>quinolinic acid transmembrane transport</classLabel>
<newAxiom>&apos;quinolinic acid transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0099150</classIRI>
<classLabel>regulation of postsynaptic specialization assembly</classLabel>
<newAxiom>&apos;regulation of postsynaptic specialization assembly&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099175</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903400</classIRI>
<classLabel>L-arginine transmembrane transport</classLabel>
<newAxiom>&apos;L-arginine transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903401</classIRI>
<classLabel>L-lysine transmembrane transport</classLabel>
<newAxiom>&apos;L-lysine transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903350</classIRI>
<classLabel>response to dopamine</classLabel>
<newAxiom>&apos;response to dopamine&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903352</classIRI>
<classLabel>L-ornithine transmembrane transport</classLabel>
<newAxiom>&apos;L-ornithine transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903351</classIRI>
<classLabel>cellular response to dopamine</classLabel>
<newAxiom>&apos;cellular response to dopamine&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0089711</classIRI>
<classLabel>L-glutamate transmembrane transport</classLabel>
<newAxiom>&apos;L-glutamate transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0089707</classIRI>
<classLabel>L-lysine transmembrane export from vacuole</classLabel>
<newAxiom>&apos;L-lysine transmembrane export from vacuole&apos; SubClassOf &apos;drug transmembrane export&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0089706</classIRI>
<classLabel>L-ornithine transmembrane export from vacuole</classLabel>
<newAxiom>&apos;L-ornithine transmembrane export from vacuole&apos; SubClassOf &apos;drug transmembrane export&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0089704</classIRI>
<classLabel>L-glutamate transmembrane export from vacuole</classLabel>
<newAxiom>&apos;L-glutamate transmembrane export from vacuole&apos; SubClassOf &apos;neurotransmitter transport&apos;</newAxiom>
<newAxiom>&apos;L-glutamate transmembrane export from vacuole&apos; SubClassOf &apos;drug transmembrane export&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0089709</classIRI>
<classLabel>L-histidine transmembrane transport</classLabel>
<newAxiom>&apos;L-histidine transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0089708</classIRI>
<classLabel>L-histidine transmembrane export from vacuole</classLabel>
<newAxiom>&apos;L-histidine transmembrane export from vacuole&apos; SubClassOf &apos;drug transmembrane export&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0099068</classIRI>
<classLabel>postsynapse assembly</classLabel>
<newAxiom>&apos;postsynapse assembly&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099173</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0099054</classIRI>
<classLabel>presynapse assembly</classLabel>
<newAxiom>&apos;presynapse assembly&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099172</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0002058</classIRI>
<classLabel>uracil binding</classLabel>
<newAxiom>&apos;uracil binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0002038</classIRI>
<classLabel>positive regulation of L-glutamate transport</classLabel>
<newAxiom>&apos;positive regulation of L-glutamate transport&apos; SubClassOf &apos;positive regulation of neurotransmitter transport&apos;</newAxiom>
<newAxiom>&apos;positive regulation of L-glutamate transport&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0002037</classIRI>
<classLabel>negative regulation of L-glutamate transport</classLabel>
<newAxiom>&apos;negative regulation of L-glutamate transport&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
<newAxiom>&apos;negative regulation of L-glutamate transport&apos; SubClassOf &apos;negative regulation of neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0002036</classIRI>
<classLabel>regulation of L-glutamate transport</classLabel>
<newAxiom>&apos;regulation of L-glutamate transport&apos; SubClassOf &apos;regulation of neurotransmitter transport&apos;</newAxiom>
<newAxiom>&apos;regulation of L-glutamate transport&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903449</classIRI>
<classLabel>androst-4-ene-3,17-dione biosynthetic process</classLabel>
<newAxiom>&apos;androst-4-ene-3,17-dione biosynthetic process&apos; SubClassOf &apos;hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0014058</classIRI>
<classLabel>negative regulation of acetylcholine secretion, neurotransmission</classLabel>
<newAxiom>&apos;negative regulation of acetylcholine secretion, neurotransmission&apos; SubClassOf &apos;negative regulation of hormone secretion&apos;</newAxiom>
<newAxiom>&apos;negative regulation of acetylcholine secretion, neurotransmission&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0014059</classIRI>
<classLabel>regulation of dopamine secretion</classLabel>
<newAxiom>&apos;regulation of dopamine secretion&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0014056</classIRI>
<classLabel>regulation of acetylcholine secretion, neurotransmission</classLabel>
<newAxiom>&apos;regulation of acetylcholine secretion, neurotransmission&apos; SubClassOf &apos;regulation of hormone secretion&apos;</newAxiom>
<newAxiom>&apos;regulation of acetylcholine secretion, neurotransmission&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0014057</classIRI>
<classLabel>positive regulation of acetylcholine secretion, neurotransmission</classLabel>
<newAxiom>&apos;positive regulation of acetylcholine secretion, neurotransmission&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
<newAxiom>&apos;positive regulation of acetylcholine secretion, neurotransmission&apos; SubClassOf &apos;positive regulation of hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0014054</classIRI>
<classLabel>positive regulation of gamma-aminobutyric acid secretion</classLabel>
<newAxiom>&apos;positive regulation of gamma-aminobutyric acid secretion&apos; SubClassOf &apos;positive regulation of neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0014052</classIRI>
<classLabel>regulation of gamma-aminobutyric acid secretion</classLabel>
<newAxiom>&apos;regulation of gamma-aminobutyric acid secretion&apos; SubClassOf &apos;regulation of neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0014053</classIRI>
<classLabel>negative regulation of gamma-aminobutyric acid secretion</classLabel>
<newAxiom>&apos;negative regulation of gamma-aminobutyric acid secretion&apos; SubClassOf &apos;negative regulation of neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0014063</classIRI>
<classLabel>negative regulation of serotonin secretion</classLabel>
<newAxiom>&apos;negative regulation of serotonin secretion&apos; SubClassOf &apos;negative regulation of neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0014064</classIRI>
<classLabel>positive regulation of serotonin secretion</classLabel>
<newAxiom>&apos;positive regulation of serotonin secretion&apos; SubClassOf &apos;positive regulation of neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0014062</classIRI>
<classLabel>regulation of serotonin secretion</classLabel>
<newAxiom>&apos;regulation of serotonin secretion&apos; SubClassOf &apos;regulation of neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903455</classIRI>
<classLabel>negative regulation of androst-4-ene-3,17-dione biosynthetic process</classLabel>
<deletedAxiom>&apos;negative regulation of androst-4-ene-3,17-dione biosynthetic process&apos; SubClassOf &apos;negative regulation of cellular biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of androst-4-ene-3,17-dione biosynthetic process&apos; SubClassOf &apos;negative regulation of hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903454</classIRI>
<classLabel>regulation of androst-4-ene-3,17-dione biosynthetic process</classLabel>
<newAxiom>&apos;regulation of androst-4-ene-3,17-dione biosynthetic process&apos; SubClassOf &apos;regulation of hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903456</classIRI>
<classLabel>positive regulation of androst-4-ene-3,17-dione biosynthetic process</classLabel>
<deletedAxiom>&apos;positive regulation of androst-4-ene-3,17-dione biosynthetic process&apos; SubClassOf &apos;positive regulation of cellular biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;positive regulation of androst-4-ene-3,17-dione biosynthetic process&apos; SubClassOf &apos;positive regulation of hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0014076</classIRI>
<classLabel>response to fluoxetine</classLabel>
<newAxiom>&apos;response to fluoxetine&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903493</classIRI>
<classLabel>response to clopidogrel</classLabel>
<newAxiom>&apos;response to clopidogrel&apos; SubClassOf &apos;response to platelet aggregation inhibitor&apos;</newAxiom>
<newAxiom>&apos;response to clopidogrel&apos; SubClassOf &apos;response to anticoagulant&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903492</classIRI>
<classLabel>response to acetylsalicylate</classLabel>
<newAxiom>&apos;response to acetylsalicylate&apos; SubClassOf &apos;response to platelet aggregation inhibitor&apos;</newAxiom>
<newAxiom>&apos;response to acetylsalicylate&apos; SubClassOf &apos;response to anticoagulant&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903495</classIRI>
<classLabel>cellular response to dehydroepiandrosterone</classLabel>
<newAxiom>&apos;cellular response to dehydroepiandrosterone&apos; SubClassOf &apos;cellular response to hormone stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903494</classIRI>
<classLabel>response to dehydroepiandrosterone</classLabel>
<newAxiom>&apos;response to dehydroepiandrosterone&apos; SubClassOf &apos;response to hormone&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0002005</classIRI>
<classLabel>angiotensin catabolic process in blood</classLabel>
<newAxiom>&apos;angiotensin catabolic process in blood&apos; SubClassOf &apos;hormone catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903594</classIRI>
<classLabel>negative regulation of histamine secretion by mast cell</classLabel>
<newAxiom>&apos;negative regulation of histamine secretion by mast cell&apos; SubClassOf &apos;negative regulation of neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903593</classIRI>
<classLabel>regulation of histamine secretion by mast cell</classLabel>
<newAxiom>&apos;regulation of histamine secretion by mast cell&apos; SubClassOf &apos;regulation of neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903595</classIRI>
<classLabel>positive regulation of histamine secretion by mast cell</classLabel>
<newAxiom>&apos;positive regulation of histamine secretion by mast cell&apos; SubClassOf &apos;positive regulation of neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0016594</classIRI>
<classLabel>glycine binding</classLabel>
<newAxiom>&apos;glycine binding&apos; SubClassOf &apos;neurotransmitter binding&apos;</newAxiom>
<newAxiom>&apos;glycine binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903576</classIRI>
<classLabel>response to L-arginine</classLabel>
<newAxiom>&apos;response to L-arginine&apos; SubClassOf &apos;response to nutrient&apos;</newAxiom>
<newAxiom>&apos;response to L-arginine&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903577</classIRI>
<classLabel>cellular response to L-arginine</classLabel>
<newAxiom>&apos;cellular response to L-arginine&apos; SubClassOf &apos;cellular response to nutrient&apos;</newAxiom>
<newAxiom>&apos;cellular response to L-arginine&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0090514</classIRI>
<classLabel>L-tyrosine transmembrane import into vacuole</classLabel>
<newAxiom>&apos;L-tyrosine transmembrane import into vacuole&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903710</classIRI>
<classLabel>spermine transmembrane transport</classLabel>
<newAxiom>&apos;spermine transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903718</classIRI>
<classLabel>cellular response to ammonia</classLabel>
<newAxiom>&apos;cellular response to ammonia&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903717</classIRI>
<classLabel>response to ammonia</classLabel>
<newAxiom>&apos;response to ammonia&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901107</classIRI>
<classLabel>granaticin metabolic process</classLabel>
<newAxiom>&apos;granaticin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901108</classIRI>
<classLabel>granaticin catabolic process</classLabel>
<newAxiom>&apos;granaticin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901050</classIRI>
<classLabel>atropine catabolic process</classLabel>
<deletedAxiom>&apos;atropine catabolic process&apos; SubClassOf &apos;catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;atropine catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901067</classIRI>
<classLabel>ferulate catabolic process</classLabel>
<newAxiom>&apos;ferulate catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901034</classIRI>
<classLabel>regulation of L-glutamine import</classLabel>
<newAxiom>&apos;regulation of L-glutamine import&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901035</classIRI>
<classLabel>negative regulation of L-glutamine import</classLabel>
<newAxiom>&apos;negative regulation of L-glutamine import&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901036</classIRI>
<classLabel>positive regulation of L-glutamine import</classLabel>
<newAxiom>&apos;positive regulation of L-glutamine import&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901042</classIRI>
<classLabel>positive regulation of L-arginine import</classLabel>
<newAxiom>&apos;positive regulation of L-arginine import&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901049</classIRI>
<classLabel>atropine metabolic process</classLabel>
<deletedAxiom>&apos;atropine metabolic process&apos; SubClassOf &apos;metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;atropine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901087</classIRI>
<classLabel>benzylpenicillin catabolic process</classLabel>
<newAxiom>&apos;benzylpenicillin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0090416</classIRI>
<classLabel>nicotinate transmembrane transporter activity</classLabel>
<newAxiom>&apos;nicotinate transmembrane transporter activity&apos; SubClassOf &apos;vitamin transmembrane transporter activity&apos;</newAxiom>
<newAxiom>&apos;nicotinate transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903803</classIRI>
<classLabel>L-glutamine import across plasma membrane</classLabel>
<newAxiom>&apos;L-glutamine import across plasma membrane&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903808</classIRI>
<classLabel>L-tyrosine import across plasma membrane</classLabel>
<newAxiom>&apos;L-tyrosine import across plasma membrane&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903807</classIRI>
<classLabel>L-threonine import across plasma membrane</classLabel>
<newAxiom>&apos;L-threonine import across plasma membrane&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903811</classIRI>
<classLabel>L-asparagine import across plasma membrane</classLabel>
<newAxiom>&apos;L-asparagine import across plasma membrane&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903880</classIRI>
<classLabel>17alpha-hydroxyprogesterone binding</classLabel>
<newAxiom>&apos;17alpha-hydroxyprogesterone binding&apos; SubClassOf &apos;hormone binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000082</classIRI>
<classLabel>regulation of L-ascorbic acid biosynthetic process</classLabel>
<newAxiom>&apos;regulation of L-ascorbic acid biosynthetic process&apos; SubClassOf &apos;regulation of coenzyme metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000083</classIRI>
<classLabel>negative regulation of L-ascorbic acid biosynthetic process</classLabel>
<newAxiom>&apos;negative regulation of L-ascorbic acid biosynthetic process&apos; SubClassOf &apos;negative regulation of coenzyme metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018970</classIRI>
<classLabel>toluene metabolic process</classLabel>
<newAxiom>&apos;toluene metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018977</classIRI>
<classLabel>1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process</classLabel>
<newAxiom>&apos;1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018979</classIRI>
<classLabel>trichloroethylene metabolic process</classLabel>
<newAxiom>&apos;trichloroethylene metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903791</classIRI>
<classLabel>uracil transmembrane transport</classLabel>
<newAxiom>&apos;uracil transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2000031</classIRI>
<classLabel>regulation of salicylic acid mediated signaling pathway</classLabel>
<newAxiom>&apos;regulation of salicylic acid mediated signaling pathway&apos; SubClassOf &apos;regulation of cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903794</classIRI>
<classLabel>cortisol binding</classLabel>
<newAxiom>&apos;cortisol binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0043924</classIRI>
<classLabel>suramin binding</classLabel>
<newAxiom>&apos;suramin binding&apos; SubClassOf &apos;organic acid binding&apos;</newAxiom>
<newAxiom>&apos;suramin binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018980</classIRI>
<classLabel>2,4,5-trichlorophenoxyacetic acid metabolic process</classLabel>
<newAxiom>&apos;2,4,5-trichlorophenoxyacetic acid metabolic process&apos; SubClassOf &apos;xenobiotic metabolic process&apos;</newAxiom>
<newAxiom>&apos;2,4,5-trichlorophenoxyacetic acid metabolic process&apos; SubClassOf &apos;auxin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018982</classIRI>
<classLabel>vanillin metabolic process</classLabel>
<newAxiom>&apos;vanillin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018984</classIRI>
<classLabel>naphthalenesulfonate metabolic process</classLabel>
<deletedAxiom>&apos;naphthalenesulfonate metabolic process&apos; SubClassOf &apos;organic substance metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;naphthalenesulfonate metabolic process&apos; SubClassOf &apos;organic acid metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901149</classIRI>
<classLabel>salicylic acid binding</classLabel>
<newAxiom>&apos;salicylic acid binding&apos; SubClassOf &apos;hormone binding&apos;</newAxiom>
<newAxiom>&apos;salicylic acid binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901113</classIRI>
<classLabel>erythromycin metabolic process</classLabel>
<newAxiom>&apos;erythromycin metabolic process&apos; SubClassOf &apos;xenobiotic metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901114</classIRI>
<classLabel>erythromycin catabolic process</classLabel>
<newAxiom>&apos;erythromycin catabolic process&apos; SubClassOf &apos;xenobiotic catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901119</classIRI>
<classLabel>tobramycin metabolic process</classLabel>
<newAxiom>&apos;tobramycin metabolic process&apos; SubClassOf &apos;toxin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901120</classIRI>
<classLabel>tobramycin catabolic process</classLabel>
<newAxiom>&apos;tobramycin catabolic process&apos; SubClassOf &apos;toxin catabolic process&apos;</newAxiom>
<newAxiom>&apos;tobramycin catabolic process&apos; SubClassOf &apos;detoxification of nitrogen compound&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901121</classIRI>
<classLabel>tobramycin biosynthetic process</classLabel>
<newAxiom>&apos;tobramycin biosynthetic process&apos; SubClassOf &apos;toxin biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903785</classIRI>
<classLabel>L-valine transmembrane transport</classLabel>
<newAxiom>&apos;L-valine transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903787</classIRI>
<classLabel>negative regulation of glutathione biosynthetic process</classLabel>
<newAxiom>&apos;negative regulation of glutathione biosynthetic process&apos; SubClassOf &apos;negative regulation of cofactor metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901125</classIRI>
<classLabel>candicidin metabolic process</classLabel>
<newAxiom>&apos;candicidin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903786</classIRI>
<classLabel>regulation of glutathione biosynthetic process</classLabel>
<newAxiom>&apos;regulation of glutathione biosynthetic process&apos; SubClassOf &apos;regulation of cofactor metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901126</classIRI>
<classLabel>candicidin catabolic process</classLabel>
<newAxiom>&apos;candicidin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903788</classIRI>
<classLabel>positive regulation of glutathione biosynthetic process</classLabel>
<newAxiom>&apos;positive regulation of glutathione biosynthetic process&apos; SubClassOf &apos;positive regulation of cofactor metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901170</classIRI>
<classLabel>naphthalene catabolic process</classLabel>
<newAxiom>&apos;naphthalene catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901181</classIRI>
<classLabel>negative regulation of cellular response to caffeine</classLabel>
<deletedAxiom>&apos;negative regulation of cellular response to caffeine&apos; SubClassOf &apos;negative regulation of response to stimulus&apos;</deletedAxiom>
<deletedAxiom>&apos;negative regulation of cellular response to caffeine&apos; SubClassOf &apos;negative regulation of cellular process&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of cellular response to caffeine&apos; SubClassOf &apos;negative regulation of cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901150</classIRI>
<classLabel>vistamycin metabolic process</classLabel>
<newAxiom>&apos;vistamycin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901151</classIRI>
<classLabel>vistamycin catabolic process</classLabel>
<newAxiom>&apos;vistamycin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901153</classIRI>
<classLabel>paromomycin metabolic process</classLabel>
<newAxiom>&apos;paromomycin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901154</classIRI>
<classLabel>paromomycin catabolic process</classLabel>
<newAxiom>&apos;paromomycin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903925</classIRI>
<classLabel>response to bisphenol A</classLabel>
<newAxiom>&apos;response to bisphenol A&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
<newAxiom>&apos;response to bisphenol A&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
<newAxiom>&apos;response to bisphenol A&apos; SubClassOf &apos;response to hormone&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903924</classIRI>
<classLabel>estradiol binding</classLabel>
<newAxiom>&apos;estradiol binding&apos; SubClassOf &apos;estrogen binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903927</classIRI>
<classLabel>response to cyanide</classLabel>
<newAxiom>&apos;response to cyanide&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903926</classIRI>
<classLabel>cellular response to bisphenol A</classLabel>
<newAxiom>&apos;cellular response to bisphenol A&apos; SubClassOf &apos;cellular response to hormone stimulus&apos;</newAxiom>
<newAxiom>&apos;cellular response to bisphenol A&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to bisphenol A&apos; SubClassOf &apos;cellular response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903928</classIRI>
<classLabel>cellular response to cyanide</classLabel>
<newAxiom>&apos;cellular response to cyanide&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903956</classIRI>
<classLabel>response to latrunculin B</classLabel>
<newAxiom>&apos;response to latrunculin B&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903957</classIRI>
<classLabel>cellular response to latrunculin B</classLabel>
<newAxiom>&apos;cellular response to latrunculin B&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018900</classIRI>
<classLabel>dichloromethane metabolic process</classLabel>
<deletedAxiom>&apos;dichloromethane metabolic process&apos; SubClassOf &apos;chlorinated hydrocarbon metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;dichloromethane metabolic process&apos; SubClassOf &apos;organic substance metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018901</classIRI>
<classLabel>2,4-dichlorophenoxyacetic acid metabolic process</classLabel>
<newAxiom>&apos;2,4-dichlorophenoxyacetic acid metabolic process&apos; SubClassOf &apos;xenobiotic metabolic process&apos;</newAxiom>
<newAxiom>&apos;2,4-dichlorophenoxyacetic acid metabolic process&apos; SubClassOf &apos;auxin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903967</classIRI>
<classLabel>response to micafungin</classLabel>
<newAxiom>&apos;response to micafungin&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903968</classIRI>
<classLabel>cellular response to micafungin</classLabel>
<newAxiom>&apos;cellular response to micafungin&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018912</classIRI>
<classLabel>1,4-dichlorobenzene metabolic process</classLabel>
<newAxiom>&apos;1,4-dichlorobenzene metabolic process&apos; SubClassOf &apos;insecticide metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018907</classIRI>
<classLabel>dimethyl sulfoxide metabolic process</classLabel>
<newAxiom>&apos;dimethyl sulfoxide metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903936</classIRI>
<classLabel>cellular response to sodium arsenite</classLabel>
<newAxiom>&apos;cellular response to sodium arsenite&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
<newAxiom>&apos;cellular response to sodium arsenite&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903935</classIRI>
<classLabel>response to sodium arsenite</classLabel>
<newAxiom>&apos;response to sodium arsenite&apos; SubClassOf &apos;response to herbicide&apos;</newAxiom>
<newAxiom>&apos;response to sodium arsenite&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
<newAxiom>&apos;response to sodium arsenite&apos; SubClassOf &apos;response to insecticide&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903938</classIRI>
<classLabel>cellular response to acrylamide</classLabel>
<newAxiom>&apos;cellular response to acrylamide&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903937</classIRI>
<classLabel>response to acrylamide</classLabel>
<newAxiom>&apos;response to acrylamide&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018917</classIRI>
<classLabel>fluorene metabolic process</classLabel>
<newAxiom>&apos;fluorene metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018918</classIRI>
<classLabel>gallate metabolic process</classLabel>
<newAxiom>&apos;gallate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018919</classIRI>
<classLabel>gamma-1,2,3,4,5,6-hexachlorocyclohexane metabolic process</classLabel>
<newAxiom>&apos;gamma-1,2,3,4,5,6-hexachlorocyclohexane metabolic process&apos; SubClassOf &apos;insecticide metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018930</classIRI>
<classLabel>3-methylquinoline metabolic process</classLabel>
<newAxiom>&apos;3-methylquinoline metabolic process&apos; SubClassOf &apos;xenobiotic metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018931</classIRI>
<classLabel>naphthalene metabolic process</classLabel>
<newAxiom>&apos;naphthalene metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018933</classIRI>
<classLabel>nicotine metabolic process</classLabel>
<deletedAxiom>&apos;nicotine metabolic process&apos; SubClassOf &apos;metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;nicotine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018937</classIRI>
<classLabel>nitroglycerin metabolic process</classLabel>
<newAxiom>&apos;nitroglycerin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018938</classIRI>
<classLabel>2-nitropropane metabolic process</classLabel>
<newAxiom>&apos;2-nitropropane metabolic process&apos; SubClassOf &apos;organic substance metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031926</classIRI>
<classLabel>pyridoxal phosphate transmembrane transporter activity</classLabel>
<newAxiom>&apos;pyridoxal phosphate transmembrane transporter activity&apos; SubClassOf &apos;coenzyme transmembrane transporter activity&apos;</newAxiom>
<newAxiom>&apos;pyridoxal phosphate transmembrane transporter activity&apos; SubClassOf &apos;vitamin B6 transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031925</classIRI>
<classLabel>pyridoxal transmembrane transporter activity</classLabel>
<newAxiom>&apos;pyridoxal transmembrane transporter activity&apos; SubClassOf &apos;cofactor transmembrane transporter activity&apos;</newAxiom>
<newAxiom>&apos;pyridoxal transmembrane transporter activity&apos; SubClassOf &apos;vitamin B6 transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031928</classIRI>
<classLabel>pyridoxine transmembrane transporter activity</classLabel>
<newAxiom>&apos;pyridoxine transmembrane transporter activity&apos; SubClassOf &apos;vitamin B6 transmembrane transporter activity&apos;</newAxiom>
<newAxiom>&apos;pyridoxine transmembrane transporter activity&apos; SubClassOf &apos;cofactor transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031927</classIRI>
<classLabel>pyridoxamine transmembrane transporter activity</classLabel>
<newAxiom>&apos;pyridoxamine transmembrane transporter activity&apos; SubClassOf &apos;vitamin B6 transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018952</classIRI>
<classLabel>parathion metabolic process</classLabel>
<newAxiom>&apos;parathion metabolic process&apos; SubClassOf &apos;insecticide metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031920</classIRI>
<classLabel>pyridoxal transport</classLabel>
<newAxiom>&apos;pyridoxal transport&apos; SubClassOf &apos;cofactor transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018954</classIRI>
<classLabel>pentaerythritol tetranitrate metabolic process</classLabel>
<newAxiom>&apos;pentaerythritol tetranitrate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018955</classIRI>
<classLabel>phenanthrene metabolic process</classLabel>
<newAxiom>&apos;phenanthrene metabolic process&apos; SubClassOf &apos;xenobiotic metabolic process&apos;</newAxiom>
<newAxiom>&apos;phenanthrene metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031921</classIRI>
<classLabel>pyridoxal phosphate transport</classLabel>
<newAxiom>&apos;pyridoxal phosphate transport&apos; SubClassOf &apos;coenzyme transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031924</classIRI>
<classLabel>vitamin B6 transmembrane transporter activity</classLabel>
<newAxiom>&apos;vitamin B6 transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031923</classIRI>
<classLabel>pyridoxine transport</classLabel>
<newAxiom>&apos;pyridoxine transport&apos; SubClassOf &apos;cofactor transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031919</classIRI>
<classLabel>vitamin B6 transport</classLabel>
<newAxiom>&apos;vitamin B6 transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903981</classIRI>
<classLabel>enterobactin binding</classLabel>
<newAxiom>&apos;enterobactin binding&apos; SubClassOf &apos;cofactor binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901322</classIRI>
<classLabel>response to chloramphenicol</classLabel>
<newAxiom>&apos;response to chloramphenicol&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901323</classIRI>
<classLabel>response to erythromycin</classLabel>
<newAxiom>&apos;response to erythromycin&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901324</classIRI>
<classLabel>response to trichodermin</classLabel>
<newAxiom>&apos;response to trichodermin&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901326</classIRI>
<classLabel>response to tetracycline</classLabel>
<newAxiom>&apos;response to tetracycline&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901327</classIRI>
<classLabel>response to tacrolimus</classLabel>
<deletedAxiom>&apos;response to tacrolimus&apos; SubClassOf &apos;response to chemical&apos;</deletedAxiom>
<newAxiom>&apos;response to tacrolimus&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901328</classIRI>
<classLabel>response to cytochalasin B</classLabel>
<newAxiom>&apos;response to cytochalasin B&apos; SubClassOf &apos;response to platelet aggregation inhibitor&apos;</newAxiom>
<newAxiom>&apos;response to cytochalasin B&apos; SubClassOf &apos;response to mycotoxin&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0016208</classIRI>
<classLabel>AMP binding</classLabel>
<newAxiom>&apos;AMP binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901267</classIRI>
<classLabel>cephalosporin C catabolic process</classLabel>
<newAxiom>&apos;cephalosporin C catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018874</classIRI>
<classLabel>benzoate metabolic process</classLabel>
<newAxiom>&apos;benzoate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901235</classIRI>
<classLabel>(R)-carnitine transmembrane transporter activity</classLabel>
<newAxiom>&apos;(R)-carnitine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
<newAxiom>&apos;(R)-carnitine transmembrane transporter activity&apos; SubClassOf &apos;vitamin transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018881</classIRI>
<classLabel>bromoxynil metabolic process</classLabel>
<newAxiom>&apos;bromoxynil metabolic process&apos; SubClassOf &apos;xenobiotic metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018885</classIRI>
<classLabel>carbon tetrachloride metabolic process</classLabel>
<deletedAxiom>&apos;carbon tetrachloride metabolic process&apos; SubClassOf &apos;chlorinated hydrocarbon metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;carbon tetrachloride metabolic process&apos; SubClassOf &apos;organic substance metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018889</classIRI>
<classLabel>2-chloro-N-isopropylacetanilide metabolic process</classLabel>
<newAxiom>&apos;2-chloro-N-isopropylacetanilide metabolic process&apos; SubClassOf &apos;xenobiotic metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018893</classIRI>
<classLabel>dibenzofuran metabolic process</classLabel>
<newAxiom>&apos;dibenzofuran metabolic process&apos; SubClassOf &apos;xenobiotic metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018894</classIRI>
<classLabel>dibenzo-p-dioxin metabolic process</classLabel>
<newAxiom>&apos;dibenzo-p-dioxin metabolic process&apos; SubClassOf &apos;xenobiotic metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018895</classIRI>
<classLabel>dibenzothiophene metabolic process</classLabel>
<newAxiom>&apos;dibenzothiophene metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018896</classIRI>
<classLabel>dibenzothiophene catabolic process</classLabel>
<newAxiom>&apos;dibenzothiophene catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018899</classIRI>
<classLabel>1,2-dichloroethane metabolic process</classLabel>
<deletedAxiom>&apos;1,2-dichloroethane metabolic process&apos; SubClassOf &apos;chlorinated hydrocarbon metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;1,2-dichloroethane metabolic process&apos; SubClassOf &apos;organic substance metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0043879</classIRI>
<classLabel>glycolate transmembrane transporter activity</classLabel>
<newAxiom>&apos;glycolate transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901413</classIRI>
<classLabel>regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA</classLabel>
<newAxiom>&apos;regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA&apos; SubClassOf &apos;regulation of neurotransmitter levels&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901416</classIRI>
<classLabel>regulation of response to ethanol</classLabel>
<newAxiom>&apos;regulation of response to ethanol&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901417</classIRI>
<classLabel>negative regulation of response to ethanol</classLabel>
<newAxiom>&apos;negative regulation of response to ethanol&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901418</classIRI>
<classLabel>positive regulation of response to ethanol</classLabel>
<newAxiom>&apos;positive regulation of response to ethanol&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901424</classIRI>
<classLabel>response to toluene</classLabel>
<newAxiom>&apos;response to toluene&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
<newAxiom>&apos;response to toluene&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901425</classIRI>
<classLabel>response to formic acid</classLabel>
<newAxiom>&apos;response to formic acid&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006809</classIRI>
<classLabel>nitric oxide biosynthetic process</classLabel>
<newAxiom>&apos;nitric oxide biosynthetic process&apos; SubClassOf &apos;neurotransmitter biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901454</classIRI>
<classLabel>regulation of response to toluene</classLabel>
<deletedAxiom>&apos;regulation of response to toluene&apos; SubClassOf &apos;regulation of response to stimulus&apos;</deletedAxiom>
<newAxiom>&apos;regulation of response to toluene&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901455</classIRI>
<classLabel>negative regulation of response to toluene</classLabel>
<deletedAxiom>&apos;negative regulation of response to toluene&apos; SubClassOf &apos;negative regulation of response to stimulus&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of response to toluene&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901456</classIRI>
<classLabel>positive regulation of response to toluene</classLabel>
<deletedAxiom>&apos;positive regulation of response to toluene&apos; SubClassOf &apos;positive regulation of response to stimulus&apos;</deletedAxiom>
<newAxiom>&apos;positive regulation of response to toluene&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006837</classIRI>
<classLabel>serotonin transport</classLabel>
<newAxiom>&apos;serotonin transport&apos; SubClassOf &apos;neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901460</classIRI>
<classLabel>regulation of response to formic acid</classLabel>
<deletedAxiom>&apos;regulation of response to formic acid&apos; SubClassOf &apos;regulation of response to stimulus&apos;</deletedAxiom>
<newAxiom>&apos;regulation of response to formic acid&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901461</classIRI>
<classLabel>negative regulation of response to formic acid</classLabel>
<deletedAxiom>&apos;negative regulation of response to formic acid&apos; SubClassOf &apos;negative regulation of response to stimulus&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of response to formic acid&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901462</classIRI>
<classLabel>positive regulation of response to formic acid</classLabel>
<deletedAxiom>&apos;positive regulation of response to formic acid&apos; SubClassOf &apos;positive regulation of response to stimulus&apos;</deletedAxiom>
<newAxiom>&apos;positive regulation of response to formic acid&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006749</classIRI>
<classLabel>glutathione metabolic process</classLabel>
<newAxiom>&apos;glutathione metabolic process&apos; SubClassOf &apos;cofactor metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006751</classIRI>
<classLabel>glutathione catabolic process</classLabel>
<newAxiom>&apos;glutathione catabolic process&apos; SubClassOf &apos;cofactor catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006750</classIRI>
<classLabel>glutathione biosynthetic process</classLabel>
<newAxiom>&apos;glutathione biosynthetic process&apos; SubClassOf &apos;cofactor biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006768</classIRI>
<classLabel>biotin metabolic process</classLabel>
<deletedAxiom>&apos;biotin metabolic process&apos; SubClassOf &apos;cofactor metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;biotin metabolic process&apos; SubClassOf &apos;coenzyme metabolic process&apos;</newAxiom>
<newAxiom>&apos;biotin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006769</classIRI>
<classLabel>nicotinamide metabolic process</classLabel>
<newAxiom>&apos;nicotinamide metabolic process&apos; SubClassOf &apos;cofactor metabolic process&apos;</newAxiom>
<newAxiom>&apos;nicotinamide metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901354</classIRI>
<classLabel>response to L-canavanine</classLabel>
<newAxiom>&apos;response to L-canavanine&apos; SubClassOf &apos;response to insecticide&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006771</classIRI>
<classLabel>riboflavin metabolic process</classLabel>
<newAxiom>&apos;riboflavin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901355</classIRI>
<classLabel>response to rapamycin</classLabel>
<newAxiom>&apos;response to rapamycin&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0016168</classIRI>
<classLabel>chlorophyll binding</classLabel>
<newAxiom>&apos;chlorophyll binding&apos; SubClassOf &apos;cofactor binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006704</classIRI>
<classLabel>glucocorticoid biosynthetic process</classLabel>
<newAxiom>&apos;glucocorticoid biosynthetic process&apos; SubClassOf &apos;hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006709</classIRI>
<classLabel>progesterone catabolic process</classLabel>
<newAxiom>&apos;progesterone catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006713</classIRI>
<classLabel>glucocorticoid catabolic process</classLabel>
<newAxiom>&apos;glucocorticoid catabolic process&apos; SubClassOf &apos;hormone catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901554</classIRI>
<classLabel>response to paracetamol</classLabel>
<newAxiom>&apos;response to paracetamol&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
<newAxiom>&apos;response to paracetamol&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901555</classIRI>
<classLabel>response to paclitaxel</classLabel>
<newAxiom>&apos;response to paclitaxel&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901556</classIRI>
<classLabel>response to candesartan</classLabel>
<newAxiom>&apos;response to candesartan&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
<newAxiom>&apos;response to candesartan&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901557</classIRI>
<classLabel>response to fenofibrate</classLabel>
<newAxiom>&apos;response to fenofibrate&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
<newAxiom>&apos;response to fenofibrate&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901558</classIRI>
<classLabel>response to metformin</classLabel>
<newAxiom>&apos;response to metformin&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
<newAxiom>&apos;response to metformin&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901559</classIRI>
<classLabel>response to ribavirin</classLabel>
<newAxiom>&apos;response to ribavirin&apos; SubClassOf &apos;response to reverse transcriptase inhibitor&apos;</newAxiom>
<newAxiom>&apos;response to ribavirin&apos; SubClassOf &apos;response to antimetabolite&apos;</newAxiom>
<newAxiom>&apos;response to ribavirin&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901561</classIRI>
<classLabel>response to benomyl</classLabel>
<newAxiom>&apos;response to benomyl&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
<newAxiom>&apos;response to benomyl&apos; SubClassOf &apos;response to fungicide&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901562</classIRI>
<classLabel>response to paraquat</classLabel>
<newAxiom>&apos;response to paraquat&apos; SubClassOf &apos;response to herbicide&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901563</classIRI>
<classLabel>response to camptothecin</classLabel>
<newAxiom>&apos;response to camptothecin&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901499</classIRI>
<classLabel>response to hexane</classLabel>
<newAxiom>&apos;response to hexane&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006653</classIRI>
<classLabel>1,2-diacyl-sn-glycero-3-phosphocholine metabolic process</classLabel>
<newAxiom>&apos;1,2-diacyl-sn-glycero-3-phosphocholine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0043636</classIRI>
<classLabel>bisphenol A catabolic process</classLabel>
<newAxiom>&apos;bisphenol A catabolic process&apos; SubClassOf &apos;hormone catabolic process&apos;</newAxiom>
<newAxiom>&apos;bisphenol A catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0043639</classIRI>
<classLabel>benzoate catabolic process</classLabel>
<newAxiom>&apos;benzoate catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901600</classIRI>
<classLabel>strigolactone metabolic process</classLabel>
<newAxiom>&apos;strigolactone metabolic process&apos; SubClassOf &apos;hormone metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901601</classIRI>
<classLabel>strigolactone biosynthetic process</classLabel>
<newAxiom>&apos;strigolactone biosynthetic process&apos; SubClassOf &apos;hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901695</classIRI>
<classLabel>tyramine biosynthetic process</classLabel>
<newAxiom>&apos;tyramine biosynthetic process&apos; SubClassOf &apos;neurotransmitter biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006600</classIRI>
<classLabel>creatine metabolic process</classLabel>
<newAxiom>&apos;creatine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901688</classIRI>
<classLabel>pantothenate import</classLabel>
<newAxiom>&apos;pantothenate import&apos; SubClassOf &apos;vitamin transport&apos;</newAxiom>
<newAxiom>&apos;pantothenate import&apos; SubClassOf &apos;cofactor transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901596</classIRI>
<classLabel>response to reversine</classLabel>
<newAxiom>&apos;response to reversine&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901597</classIRI>
<classLabel>response to carbendazim</classLabel>
<newAxiom>&apos;response to carbendazim&apos; SubClassOf &apos;response to fungicide&apos;</newAxiom>
<newAxiom>&apos;response to carbendazim&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006544</classIRI>
<classLabel>glycine metabolic process</classLabel>
<newAxiom>&apos;glycine metabolic process&apos; SubClassOf &apos;neurotransmitter metabolic process&apos;</newAxiom>
<newAxiom>&apos;glycine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006546</classIRI>
<classLabel>glycine catabolic process</classLabel>
<newAxiom>&apos;glycine catabolic process&apos; SubClassOf &apos;neurotransmitter catabolic process&apos;</newAxiom>
<newAxiom>&apos;glycine catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006545</classIRI>
<classLabel>glycine biosynthetic process</classLabel>
<newAxiom>&apos;glycine biosynthetic process&apos; SubClassOf &apos;neurotransmitter biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006559</classIRI>
<classLabel>L-phenylalanine catabolic process</classLabel>
<newAxiom>&apos;L-phenylalanine catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006558</classIRI>
<classLabel>L-phenylalanine metabolic process</classLabel>
<newAxiom>&apos;L-phenylalanine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031524</classIRI>
<classLabel>menthol metabolic process</classLabel>
<newAxiom>&apos;menthol metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006581</classIRI>
<classLabel>acetylcholine catabolic process</classLabel>
<newAxiom>&apos;acetylcholine catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
<newAxiom>&apos;acetylcholine catabolic process&apos; SubClassOf &apos;hormone catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901704</classIRI>
<classLabel>L-glutamine biosynthetic process</classLabel>
<newAxiom>&apos;L-glutamine biosynthetic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901732</classIRI>
<classLabel>quercetin metabolic process</classLabel>
<newAxiom>&apos;quercetin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
<newAxiom>&apos;quercetin metabolic process&apos; SubClassOf &apos;hormone metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901733</classIRI>
<classLabel>quercetin catabolic process</classLabel>
<newAxiom>&apos;quercetin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
<newAxiom>&apos;quercetin catabolic process&apos; SubClassOf &apos;hormone catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901734</classIRI>
<classLabel>quercetin biosynthetic process</classLabel>
<newAxiom>&apos;quercetin biosynthetic process&apos; SubClassOf &apos;hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901748</classIRI>
<classLabel>leukotriene D4 metabolic process</classLabel>
<newAxiom>&apos;leukotriene D4 metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901749</classIRI>
<classLabel>leukotriene D4 catabolic process</classLabel>
<newAxiom>&apos;leukotriene D4 catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901715</classIRI>
<classLabel>regulation of gamma-aminobutyric acid catabolic process</classLabel>
<newAxiom>&apos;regulation of gamma-aminobutyric acid catabolic process&apos; SubClassOf &apos;regulation of neurotransmitter levels&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901728</classIRI>
<classLabel>monensin A metabolic process</classLabel>
<newAxiom>&apos;monensin A metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901729</classIRI>
<classLabel>monensin A catabolic process</classLabel>
<newAxiom>&apos;monensin A catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901770</classIRI>
<classLabel>daunorubicin catabolic process</classLabel>
<newAxiom>&apos;daunorubicin catabolic process&apos; SubClassOf &apos;detoxification of nitrogen compound&apos;</newAxiom>
<newAxiom>&apos;daunorubicin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901775</classIRI>
<classLabel>mitomycin C metabolic process</classLabel>
<newAxiom>&apos;mitomycin C metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901776</classIRI>
<classLabel>mitomycin C catabolic process</classLabel>
<newAxiom>&apos;mitomycin C catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901784</classIRI>
<classLabel>p-cresol metabolic process</classLabel>
<newAxiom>&apos;p-cresol metabolic process&apos; SubClassOf &apos;toxin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901785</classIRI>
<classLabel>p-cresol catabolic process</classLabel>
<newAxiom>&apos;p-cresol catabolic process&apos; SubClassOf &apos;toxin catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901786</classIRI>
<classLabel>p-cresol biosynthetic process</classLabel>
<newAxiom>&apos;p-cresol biosynthetic process&apos; SubClassOf &apos;toxin biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901754</classIRI>
<classLabel>vitamin D3 catabolic process</classLabel>
<newAxiom>&apos;vitamin D3 catabolic process&apos; SubClassOf &apos;hormone catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901755</classIRI>
<classLabel>vitamin D3 biosynthetic process</classLabel>
<newAxiom>&apos;vitamin D3 biosynthetic process&apos; SubClassOf &apos;hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901761</classIRI>
<classLabel>oxytetracycline metabolic process</classLabel>
<newAxiom>&apos;oxytetracycline metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901762</classIRI>
<classLabel>oxytetracycline catabolic process</classLabel>
<newAxiom>&apos;oxytetracycline catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031427</classIRI>
<classLabel>response to methotrexate</classLabel>
<newAxiom>&apos;response to methotrexate&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
<newAxiom>&apos;response to methotrexate&apos; SubClassOf &apos;response to antimetabolite&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031419</classIRI>
<classLabel>cobalamin binding</classLabel>
<newAxiom>&apos;cobalamin binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
<newAxiom>&apos;cobalamin binding&apos; SubClassOf &apos;cofactor binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0043400</classIRI>
<classLabel>cortisol secretion</classLabel>
<newAxiom>&apos;cortisol secretion&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031418</classIRI>
<classLabel>L-ascorbic acid binding</classLabel>
<newAxiom>&apos;L-ascorbic acid binding&apos; SubClassOf &apos;coenzyme binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0043420</classIRI>
<classLabel>anthranilate metabolic process</classLabel>
<newAxiom>&apos;anthranilate metabolic process&apos; SubClassOf &apos;water-soluble vitamin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0043421</classIRI>
<classLabel>anthranilate catabolic process</classLabel>
<newAxiom>&apos;anthranilate catabolic process&apos; SubClassOf &apos;water-soluble vitamin catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901813</classIRI>
<classLabel>astaxanthin metabolic process</classLabel>
<newAxiom>&apos;astaxanthin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901814</classIRI>
<classLabel>astaxanthin catabolic process</classLabel>
<newAxiom>&apos;astaxanthin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070982</classIRI>
<classLabel>L-asparagine metabolic process</classLabel>
<newAxiom>&apos;L-asparagine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0043396</classIRI>
<classLabel>corticotropin-releasing hormone secretion</classLabel>
<newAxiom>&apos;corticotropin-releasing hormone secretion&apos; SubClassOf &apos;neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0043397</classIRI>
<classLabel>regulation of corticotropin-releasing hormone secretion</classLabel>
<newAxiom>&apos;regulation of corticotropin-releasing hormone secretion&apos; SubClassOf &apos;regulation of neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070968</classIRI>
<classLabel>pyrroloquinoline quinone binding</classLabel>
<newAxiom>&apos;pyrroloquinoline quinone binding&apos; SubClassOf &apos;vitamin binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901850</classIRI>
<classLabel>7,8-didemethyl-8-hydroxy-5-deazariboflavin metabolic process</classLabel>
<newAxiom>&apos;7,8-didemethyl-8-hydroxy-5-deazariboflavin metabolic process&apos; SubClassOf &apos;cofactor metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901851</classIRI>
<classLabel>7,8-didemethyl-8-hydroxy-5-deazariboflavin catabolic process</classLabel>
<newAxiom>&apos;7,8-didemethyl-8-hydroxy-5-deazariboflavin catabolic process&apos; SubClassOf &apos;cofactor catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901852</classIRI>
<classLabel>7,8-didemethyl-8-hydroxy-5-deazariboflavin biosynthetic process</classLabel>
<newAxiom>&apos;7,8-didemethyl-8-hydroxy-5-deazariboflavin biosynthetic process&apos; SubClassOf &apos;cofactor biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901867</classIRI>
<classLabel>ecgonine methyl ester metabolic process</classLabel>
<newAxiom>&apos;ecgonine methyl ester metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901868</classIRI>
<classLabel>ecgonine methyl ester catabolic process</classLabel>
<newAxiom>&apos;ecgonine methyl ester catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901847</classIRI>
<classLabel>nicotinate metabolic process</classLabel>
<newAxiom>&apos;nicotinate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
<newAxiom>&apos;nicotinate metabolic process&apos; SubClassOf &apos;water-soluble vitamin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901848</classIRI>
<classLabel>nicotinate catabolic process</classLabel>
<newAxiom>&apos;nicotinate catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
<newAxiom>&apos;nicotinate catabolic process&apos; SubClassOf &apos;water-soluble vitamin catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901849</classIRI>
<classLabel>nicotinate biosynthetic process</classLabel>
<newAxiom>&apos;nicotinate biosynthetic process&apos; SubClassOf &apos;water-soluble vitamin biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070907</classIRI>
<classLabel>histidine:histamine antiporter activity</classLabel>
<newAxiom>&apos;histidine:histamine antiporter activity&apos; SubClassOf &apos;neurotransmitter transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070908</classIRI>
<classLabel>tyrosine:tyramine antiporter activity</classLabel>
<newAxiom>&apos;tyrosine:tyramine antiporter activity&apos; SubClassOf &apos;neurotransmitter transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070927</classIRI>
<classLabel>negative regulation of ATP:ADP antiporter activity</classLabel>
<newAxiom>&apos;negative regulation of ATP:ADP antiporter activity&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070926</classIRI>
<classLabel>regulation of ATP:ADP antiporter activity</classLabel>
<newAxiom>&apos;regulation of ATP:ADP antiporter activity&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0043278</classIRI>
<classLabel>response to morphine</classLabel>
<newAxiom>&apos;response to morphine&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
<newAxiom>&apos;response to morphine&apos; SubClassOf &apos;response to anesthetic&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0043295</classIRI>
<classLabel>glutathione binding</classLabel>
<newAxiom>&apos;glutathione binding&apos; SubClassOf &apos;cofactor binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901986</classIRI>
<classLabel>response to ketamine</classLabel>
<newAxiom>&apos;response to ketamine&apos; SubClassOf &apos;response to anesthetic&apos;</newAxiom>
<newAxiom>&apos;response to ketamine&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
<newAxiom>&apos;response to ketamine&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901962</classIRI>
<classLabel>S-adenosyl-L-methionine transmembrane transport</classLabel>
<deletedAxiom>&apos;S-adenosyl-L-methionine transmembrane transport&apos; SubClassOf &apos;transmembrane transport&apos;</deletedAxiom>
<newAxiom>&apos;S-adenosyl-L-methionine transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006212</classIRI>
<classLabel>uracil catabolic process</classLabel>
<newAxiom>&apos;uracil catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1901905</classIRI>
<classLabel>response to tamsulosin</classLabel>
<newAxiom>&apos;response to tamsulosin&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070813</classIRI>
<classLabel>hydrogen sulfide metabolic process</classLabel>
<newAxiom>&apos;hydrogen sulfide metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
<newAxiom>&apos;hydrogen sulfide metabolic process&apos; SubClassOf &apos;toxin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070814</classIRI>
<classLabel>hydrogen sulfide biosynthetic process</classLabel>
<newAxiom>&apos;hydrogen sulfide biosynthetic process&apos; SubClassOf &apos;toxin biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0043132</classIRI>
<classLabel>NAD transport</classLabel>
<deletedAxiom>&apos;NAD transport&apos; SubClassOf &apos;cofactor transport&apos;</deletedAxiom>
<newAxiom>&apos;NAD transport&apos; SubClassOf &apos;coenzyme transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006196</classIRI>
<classLabel>AMP catabolic process</classLabel>
<newAxiom>&apos;AMP catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0018189</classIRI>
<classLabel>pyrroloquinoline quinone biosynthetic process</classLabel>
<newAxiom>&apos;pyrroloquinoline quinone biosynthetic process&apos; SubClassOf &apos;water-soluble vitamin biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0055129</classIRI>
<classLabel>L-proline biosynthetic process</classLabel>
<newAxiom>&apos;L-proline biosynthetic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031177</classIRI>
<classLabel>phosphopantetheine binding</classLabel>
<newAxiom>&apos;phosphopantetheine binding&apos; SubClassOf &apos;cofactor binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070781</classIRI>
<classLabel>response to biotin</classLabel>
<newAxiom>&apos;response to biotin&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070778</classIRI>
<classLabel>L-aspartate transport</classLabel>
<newAxiom>&apos;L-aspartate transport&apos; SubClassOf &apos;neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0080142</classIRI>
<classLabel>regulation of salicylic acid biosynthetic process</classLabel>
<deletedAxiom>&apos;regulation of salicylic acid biosynthetic process&apos; SubClassOf &apos;regulation of cellular biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;regulation of salicylic acid biosynthetic process&apos; SubClassOf &apos;regulation of hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0080141</classIRI>
<classLabel>regulation of jasmonic acid biosynthetic process</classLabel>
<newAxiom>&apos;regulation of jasmonic acid biosynthetic process&apos; SubClassOf &apos;regulation of hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0080151</classIRI>
<classLabel>positive regulation of salicylic acid mediated signaling pathway</classLabel>
<newAxiom>&apos;positive regulation of salicylic acid mediated signaling pathway&apos; SubClassOf &apos;positive regulation of cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0080139</classIRI>
<classLabel>borate efflux transmembrane transporter activity</classLabel>
<newAxiom>&apos;borate efflux transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0080140</classIRI>
<classLabel>regulation of jasmonic acid metabolic process</classLabel>
<newAxiom>&apos;regulation of jasmonic acid metabolic process&apos; SubClassOf &apos;regulation of hormone metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0080122</classIRI>
<classLabel>AMP transmembrane transporter activity</classLabel>
<newAxiom>&apos;AMP transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0080121</classIRI>
<classLabel>AMP transport</classLabel>
<newAxiom>&apos;AMP transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0080164</classIRI>
<classLabel>regulation of nitric oxide metabolic process</classLabel>
<newAxiom>&apos;regulation of nitric oxide metabolic process&apos; SubClassOf &apos;regulation of neurotransmitter levels&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0080170</classIRI>
<classLabel>hydrogen peroxide transmembrane transport</classLabel>
<deletedAxiom>&apos;hydrogen peroxide transmembrane transport&apos; SubClassOf &apos;transmembrane transport&apos;</deletedAxiom>
<newAxiom>&apos;hydrogen peroxide transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
<newAxiom>&apos;hydrogen peroxide transmembrane transport&apos; SubClassOf &apos;cofactor transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006103</classIRI>
<classLabel>2-oxoglutarate metabolic process</classLabel>
<newAxiom>&apos;2-oxoglutarate metabolic process&apos; SubClassOf &apos;cofactor metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006105</classIRI>
<classLabel>succinate metabolic process</classLabel>
<newAxiom>&apos;succinate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006154</classIRI>
<classLabel>adenosine catabolic process</classLabel>
<newAxiom>&apos;adenosine catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070639</classIRI>
<classLabel>vitamin D2 metabolic process</classLabel>
<newAxiom>&apos;vitamin D2 metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070640</classIRI>
<classLabel>vitamin D3 metabolic process</classLabel>
<newAxiom>&apos;vitamin D3 metabolic process&apos; SubClassOf &apos;hormone metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0080021</classIRI>
<classLabel>response to benzoic acid</classLabel>
<newAxiom>&apos;response to benzoic acid&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070689</classIRI>
<classLabel>L-threonine catabolic process to propionate</classLabel>
<newAxiom>&apos;L-threonine catabolic process to propionate&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070690</classIRI>
<classLabel>L-threonine catabolic process to acetyl-CoA</classLabel>
<newAxiom>&apos;L-threonine catabolic process to acetyl-CoA&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0008614</classIRI>
<classLabel>pyridoxine metabolic process</classLabel>
<newAxiom>&apos;pyridoxine metabolic process&apos; SubClassOf &apos;cofactor metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0008615</classIRI>
<classLabel>pyridoxine biosynthetic process</classLabel>
<newAxiom>&apos;pyridoxine biosynthetic process&apos; SubClassOf &apos;cofactor biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033602</classIRI>
<classLabel>negative regulation of dopamine secretion</classLabel>
<newAxiom>&apos;negative regulation of dopamine secretion&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033603</classIRI>
<classLabel>positive regulation of dopamine secretion</classLabel>
<newAxiom>&apos;positive regulation of dopamine secretion&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006030</classIRI>
<classLabel>chitin metabolic process</classLabel>
<newAxiom>&apos;chitin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006032</classIRI>
<classLabel>chitin catabolic process</classLabel>
<newAxiom>&apos;chitin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006054</classIRI>
<classLabel>N-acetylneuraminate metabolic process</classLabel>
<newAxiom>&apos;N-acetylneuraminate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006067</classIRI>
<classLabel>ethanol metabolic process</classLabel>
<newAxiom>&apos;ethanol metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0031000</classIRI>
<classLabel>response to caffeine</classLabel>
<newAxiom>&apos;response to caffeine&apos; SubClassOf &apos;response to diuretic&apos;</newAxiom>
<newAxiom>&apos;response to caffeine&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0006068</classIRI>
<classLabel>ethanol catabolic process</classLabel>
<newAxiom>&apos;ethanol catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033574</classIRI>
<classLabel>response to testosterone</classLabel>
<newAxiom>&apos;response to testosterone&apos; SubClassOf &apos;response to hormone&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0045574</classIRI>
<classLabel>sterigmatocystin catabolic process</classLabel>
<deletedAxiom>&apos;sterigmatocystin catabolic process&apos; SubClassOf &apos;toxin catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;sterigmatocystin catabolic process&apos; SubClassOf &apos;mycotoxin catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033595</classIRI>
<classLabel>response to genistein</classLabel>
<newAxiom>&apos;response to genistein&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
<newAxiom>&apos;response to genistein&apos; SubClassOf &apos;response to hormone&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033590</classIRI>
<classLabel>response to cobalamin</classLabel>
<newAxiom>&apos;response to cobalamin&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900980</classIRI>
<classLabel>regulation of phenazine biosynthetic process</classLabel>
<newAxiom>&apos;regulation of phenazine biosynthetic process&apos; SubClassOf &apos;regulation of secondary metabolite biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900981</classIRI>
<classLabel>negative regulation of phenazine biosynthetic process</classLabel>
<newAxiom>&apos;negative regulation of phenazine biosynthetic process&apos; SubClassOf &apos;negative regulation of secondary metabolite biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900982</classIRI>
<classLabel>positive regulation of phenazine biosynthetic process</classLabel>
<newAxiom>&apos;positive regulation of phenazine biosynthetic process&apos; SubClassOf &apos;positive regulation of secondary metabolite biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900989</classIRI>
<classLabel>scopolamine metabolic process</classLabel>
<newAxiom>&apos;scopolamine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900990</classIRI>
<classLabel>scopolamine catabolic process</classLabel>
<newAxiom>&apos;scopolamine catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0008517</classIRI>
<classLabel>folic acid transmembrane transporter activity</classLabel>
<newAxiom>&apos;folic acid transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0008520</classIRI>
<classLabel>L-ascorbate:sodium symporter activity</classLabel>
<deletedAxiom>&apos;L-ascorbate:sodium symporter activity&apos; SubClassOf &apos;monosaccharide transmembrane transporter activity&apos;</deletedAxiom>
<deletedAxiom>&apos;L-ascorbate:sodium symporter activity&apos; SubClassOf &apos;carboxylic acid transmembrane transporter activity&apos;</deletedAxiom>
<newAxiom>&apos;L-ascorbate:sodium symporter activity&apos; SubClassOf &apos;L-ascorbic acid transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033510</classIRI>
<classLabel>luteolin metabolic process</classLabel>
<newAxiom>&apos;luteolin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900920</classIRI>
<classLabel>regulation of L-glutamate import</classLabel>
<newAxiom>&apos;regulation of L-glutamate import&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
<newAxiom>&apos;regulation of L-glutamate import&apos; SubClassOf &apos;regulation of neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900921</classIRI>
<classLabel>negative regulation of L-glutamate import</classLabel>
<newAxiom>&apos;negative regulation of L-glutamate import&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
<newAxiom>&apos;negative regulation of L-glutamate import&apos; SubClassOf &apos;negative regulation of neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900922</classIRI>
<classLabel>positive regulation of L-glutamate import</classLabel>
<newAxiom>&apos;positive regulation of L-glutamate import&apos; SubClassOf &apos;positive regulation of neurotransmitter transport&apos;</newAxiom>
<newAxiom>&apos;positive regulation of L-glutamate import&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900923</classIRI>
<classLabel>regulation of glycine import</classLabel>
<newAxiom>&apos;regulation of glycine import&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
<newAxiom>&apos;regulation of glycine import&apos; SubClassOf &apos;regulation of neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900924</classIRI>
<classLabel>negative regulation of glycine import</classLabel>
<newAxiom>&apos;negative regulation of glycine import&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
<newAxiom>&apos;negative regulation of glycine import&apos; SubClassOf &apos;negative regulation of neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900925</classIRI>
<classLabel>positive regulation of glycine import</classLabel>
<newAxiom>&apos;positive regulation of glycine import&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
<newAxiom>&apos;positive regulation of glycine import&apos; SubClassOf &apos;positive regulation of neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900926</classIRI>
<classLabel>regulation of L-threonine import</classLabel>
<newAxiom>&apos;regulation of L-threonine import&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900927</classIRI>
<classLabel>negative regulation of L-threonine import</classLabel>
<newAxiom>&apos;negative regulation of L-threonine import&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900928</classIRI>
<classLabel>positive regulation of L-threonine import</classLabel>
<newAxiom>&apos;positive regulation of L-threonine import&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900929</classIRI>
<classLabel>regulation of L-tyrosine import</classLabel>
<newAxiom>&apos;regulation of L-tyrosine import&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033517</classIRI>
<classLabel>myo-inositol hexakisphosphate metabolic process</classLabel>
<newAxiom>&apos;myo-inositol hexakisphosphate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900930</classIRI>
<classLabel>negative regulation of L-tyrosine import</classLabel>
<newAxiom>&apos;negative regulation of L-tyrosine import&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900931</classIRI>
<classLabel>positive regulation of L-tyrosine import</classLabel>
<newAxiom>&apos;positive regulation of L-tyrosine import&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0045428</classIRI>
<classLabel>regulation of nitric oxide biosynthetic process</classLabel>
<newAxiom>&apos;regulation of nitric oxide biosynthetic process&apos; SubClassOf &apos;regulation of neurotransmitter levels&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0045471</classIRI>
<classLabel>response to ethanol</classLabel>
<newAxiom>&apos;response to ethanol&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
<newAxiom>&apos;response to ethanol&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033494</classIRI>
<classLabel>ferulate metabolic process</classLabel>
<newAxiom>&apos;ferulate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0045461</classIRI>
<classLabel>sterigmatocystin biosynthetic process</classLabel>
<deletedAxiom>&apos;sterigmatocystin biosynthetic process&apos; SubClassOf &apos;toxin biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;sterigmatocystin biosynthetic process&apos; SubClassOf &apos;mycotoxin biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0045460</classIRI>
<classLabel>sterigmatocystin metabolic process</classLabel>
<deletedAxiom>&apos;sterigmatocystin metabolic process&apos; SubClassOf &apos;toxin metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;sterigmatocystin metabolic process&apos; SubClassOf &apos;mycotoxin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0045490</classIRI>
<classLabel>pectin catabolic process</classLabel>
<newAxiom>&apos;pectin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0045487</classIRI>
<classLabel>gibberellin catabolic process</classLabel>
<newAxiom>&apos;gibberellin catabolic process&apos; SubClassOf &apos;hormone catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0045488</classIRI>
<classLabel>pectin metabolic process</classLabel>
<newAxiom>&apos;pectin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070484</classIRI>
<classLabel>dehydro-D-arabinono-1,4-lactone metabolic process</classLabel>
<newAxiom>&apos;dehydro-D-arabinono-1,4-lactone metabolic process&apos; SubClassOf &apos;cofactor metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070485</classIRI>
<classLabel>dehydro-D-arabinono-1,4-lactone biosynthetic process</classLabel>
<newAxiom>&apos;dehydro-D-arabinono-1,4-lactone biosynthetic process&apos; SubClassOf &apos;cofactor biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033329</classIRI>
<classLabel>kaempferol O-glucoside metabolic process</classLabel>
<newAxiom>&apos;kaempferol O-glucoside metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070301</classIRI>
<classLabel>cellular response to hydrogen peroxide</classLabel>
<newAxiom>&apos;cellular response to hydrogen peroxide&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to hydrogen peroxide&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0035923</classIRI>
<classLabel>flurbiprofen binding</classLabel>
<newAxiom>&apos;flurbiprofen binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0035943</classIRI>
<classLabel>estrone secretion</classLabel>
<deletedAxiom>&apos;estrone secretion&apos; SubClassOf &apos;secretion&apos;</deletedAxiom>
<newAxiom>&apos;estrone secretion&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
<newAxiom>&apos;estrone secretion&apos; SubClassOf &apos;hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0035938</classIRI>
<classLabel>estradiol secretion</classLabel>
<deletedAxiom>&apos;estradiol secretion&apos; SubClassOf &apos;secretion&apos;</deletedAxiom>
<newAxiom>&apos;estradiol secretion&apos; SubClassOf &apos;hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0035936</classIRI>
<classLabel>testosterone secretion</classLabel>
<deletedAxiom>&apos;testosterone secretion&apos; SubClassOf &apos;secretion&apos;</deletedAxiom>
<newAxiom>&apos;testosterone secretion&apos; SubClassOf &apos;hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0035941</classIRI>
<classLabel>androstenedione secretion</classLabel>
<deletedAxiom>&apos;androstenedione secretion&apos; SubClassOf &apos;secretion&apos;</deletedAxiom>
<newAxiom>&apos;androstenedione secretion&apos; SubClassOf &apos;hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0035942</classIRI>
<classLabel>dehydroepiandrosterone secretion</classLabel>
<deletedAxiom>&apos;dehydroepiandrosterone secretion&apos; SubClassOf &apos;secretion&apos;</deletedAxiom>
<newAxiom>&apos;dehydroepiandrosterone secretion&apos; SubClassOf &apos;hormone secretion&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033306</classIRI>
<classLabel>phytol metabolic process</classLabel>
<newAxiom>&apos;phytol metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033249</classIRI>
<classLabel>positive regulation of penicillin catabolic process</classLabel>
<newAxiom>&apos;positive regulation of penicillin catabolic process&apos; SubClassOf &apos;positive regulation of response to stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033248</classIRI>
<classLabel>negative regulation of penicillin catabolic process</classLabel>
<newAxiom>&apos;negative regulation of penicillin catabolic process&apos; SubClassOf &apos;negative regulation of response to stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0008292</classIRI>
<classLabel>acetylcholine biosynthetic process</classLabel>
<newAxiom>&apos;acetylcholine biosynthetic process&apos; SubClassOf &apos;hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0008291</classIRI>
<classLabel>acetylcholine metabolic process</classLabel>
<newAxiom>&apos;acetylcholine metabolic process&apos; SubClassOf &apos;hormone metabolic process&apos;</newAxiom>
<newAxiom>&apos;acetylcholine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033247</classIRI>
<classLabel>regulation of penicillin catabolic process</classLabel>
<newAxiom>&apos;regulation of penicillin catabolic process&apos; SubClassOf &apos;regulation of response to stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033274</classIRI>
<classLabel>response to vitamin B2</classLabel>
<newAxiom>&apos;response to vitamin B2&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033272</classIRI>
<classLabel>myo-inositol hexakisphosphate transport</classLabel>
<newAxiom>&apos;myo-inositol hexakisphosphate transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033265</classIRI>
<classLabel>choline binding</classLabel>
<newAxiom>&apos;choline binding&apos; SubClassOf &apos;neurotransmitter binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070279</classIRI>
<classLabel>vitamin B6 binding</classLabel>
<newAxiom>&apos;vitamin B6 binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070280</classIRI>
<classLabel>pyridoxal binding</classLabel>
<newAxiom>&apos;pyridoxal binding&apos; SubClassOf &apos;cofactor binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070282</classIRI>
<classLabel>pyridoxine binding</classLabel>
<newAxiom>&apos;pyridoxine binding&apos; SubClassOf &apos;cofactor binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070178</classIRI>
<classLabel>D-serine metabolic process</classLabel>
<newAxiom>&apos;D-serine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0008211</classIRI>
<classLabel>glucocorticoid metabolic process</classLabel>
<newAxiom>&apos;glucocorticoid metabolic process&apos; SubClassOf &apos;hormone metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0008215</classIRI>
<classLabel>spermine metabolic process</classLabel>
<newAxiom>&apos;spermine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0008226</classIRI>
<classLabel>tyramine receptor activity</classLabel>
<newAxiom>&apos;tyramine receptor activity&apos; SubClassOf &apos;G-protein coupled neurotransmitter receptor activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072723</classIRI>
<classLabel>cellular response to amitrole</classLabel>
<newAxiom>&apos;cellular response to amitrole&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072722</classIRI>
<classLabel>response to amitrole</classLabel>
<newAxiom>&apos;response to amitrole&apos; SubClassOf &apos;response to herbicide&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072710</classIRI>
<classLabel>response to hydroxyurea</classLabel>
<newAxiom>&apos;response to hydroxyurea&apos; SubClassOf &apos;response to antimetabolite&apos;</newAxiom>
<newAxiom>&apos;response to hydroxyurea&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072712</classIRI>
<classLabel>response to thiabendazole</classLabel>
<newAxiom>&apos;response to thiabendazole&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
<newAxiom>&apos;response to thiabendazole&apos; SubClassOf &apos;response to fungicide&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072711</classIRI>
<classLabel>cellular response to hydroxyurea</classLabel>
<newAxiom>&apos;cellular response to hydroxyurea&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072713</classIRI>
<classLabel>cellular response to thiabendazole</classLabel>
<newAxiom>&apos;cellular response to thiabendazole&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to thiabendazole&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072718</classIRI>
<classLabel>response to cisplatin</classLabel>
<deletedAxiom>&apos;response to cisplatin&apos; SubClassOf &apos;response to chemical&apos;</deletedAxiom>
<newAxiom>&apos;response to cisplatin&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
<newAxiom>&apos;response to cisplatin&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072719</classIRI>
<classLabel>cellular response to cisplatin</classLabel>
<deletedAxiom>&apos;cellular response to cisplatin&apos; SubClassOf &apos;cellular response to chemical stimulus&apos;</deletedAxiom>
<newAxiom>&apos;cellular response to cisplatin&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to cisplatin&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072762</classIRI>
<classLabel>cellular response to carbendazim</classLabel>
<newAxiom>&apos;cellular response to carbendazim&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to carbendazim&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072764</classIRI>
<classLabel>cellular response to reversine</classLabel>
<newAxiom>&apos;cellular response to reversine&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072752</classIRI>
<classLabel>cellular response to rapamycin</classLabel>
<newAxiom>&apos;cellular response to rapamycin&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072756</classIRI>
<classLabel>cellular response to paraquat</classLabel>
<newAxiom>&apos;cellular response to paraquat&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072755</classIRI>
<classLabel>cellular response to benomyl</classLabel>
<newAxiom>&apos;cellular response to benomyl&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
<newAxiom>&apos;cellular response to benomyl&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072757</classIRI>
<classLabel>cellular response to camptothecin</classLabel>
<newAxiom>&apos;cellular response to camptothecin&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033198</classIRI>
<classLabel>response to ATP</classLabel>
<newAxiom>&apos;response to ATP&apos; SubClassOf &apos;response to nutrient&apos;</newAxiom>
<newAxiom>&apos;response to ATP&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072743</classIRI>
<classLabel>cellular response to erythromycin</classLabel>
<newAxiom>&apos;cellular response to erythromycin&apos; SubClassOf &apos;cellular response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072744</classIRI>
<classLabel>cellular response to trichodermin</classLabel>
<newAxiom>&apos;cellular response to trichodermin&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072747</classIRI>
<classLabel>cellular response to chloramphenicol</classLabel>
<newAxiom>&apos;cellular response to chloramphenicol&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072746</classIRI>
<classLabel>cellular response to tetracycline</classLabel>
<newAxiom>&apos;cellular response to tetracycline&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072749</classIRI>
<classLabel>cellular response to cytochalasin B</classLabel>
<newAxiom>&apos;cellular response to cytochalasin B&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to cytochalasin B&apos; SubClassOf &apos;cellular response to mycotoxin&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072748</classIRI>
<classLabel>cellular response to tacrolimus</classLabel>
<deletedAxiom>&apos;cellular response to tacrolimus&apos; SubClassOf &apos;cellular response to chemical stimulus&apos;</deletedAxiom>
<newAxiom>&apos;cellular response to tacrolimus&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0008061</classIRI>
<classLabel>chitin binding</classLabel>
<newAxiom>&apos;chitin binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0033049</classIRI>
<classLabel>clavulanic acid metabolic process</classLabel>
<newAxiom>&apos;clavulanic acid metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0070025</classIRI>
<classLabel>carbon monoxide binding</classLabel>
<newAxiom>&apos;carbon monoxide binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
<newAxiom>&apos;carbon monoxide binding&apos; SubClassOf &apos;neurotransmitter binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072592</classIRI>
<classLabel>oxygen metabolic process</classLabel>
<deletedAxiom>&apos;oxygen metabolic process&apos; SubClassOf &apos;cellular metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;oxygen metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0060558</classIRI>
<classLabel>regulation of calcidiol 1-monooxygenase activity</classLabel>
<newAxiom>&apos;regulation of calcidiol 1-monooxygenase activity&apos; SubClassOf &apos;regulation of hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0060559</classIRI>
<classLabel>positive regulation of calcidiol 1-monooxygenase activity</classLabel>
<newAxiom>&apos;positive regulation of calcidiol 1-monooxygenase activity&apos; SubClassOf &apos;positive regulation of hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072553</classIRI>
<classLabel>terminal button organization</classLabel>
<deletedAxiom>&apos;terminal button organization&apos; SubClassOf http://purl.obolibrary.org/obo/BFO_0000050 some &apos;synapse organization&apos;</deletedAxiom>
<deletedAxiom>&apos;terminal button organization&apos; SubClassOf &apos;cellular component organization&apos;</deletedAxiom>
<newAxiom>&apos;terminal button organization&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099172</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072544</classIRI>
<classLabel>L-DOPA binding</classLabel>
<newAxiom>&apos;L-DOPA binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0035438</classIRI>
<classLabel>cyclic-di-GMP binding</classLabel>
<newAxiom>&apos;cyclic-di-GMP binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0035445</classIRI>
<classLabel>borate transmembrane transport</classLabel>
<newAxiom>&apos;borate transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0035498</classIRI>
<classLabel>carnosine metabolic process</classLabel>
<newAxiom>&apos;carnosine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0060408</classIRI>
<classLabel>regulation of acetylcholine metabolic process</classLabel>
<newAxiom>&apos;regulation of acetylcholine metabolic process&apos; SubClassOf &apos;regulation of hormone metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0060409</classIRI>
<classLabel>positive regulation of acetylcholine metabolic process</classLabel>
<newAxiom>&apos;positive regulation of acetylcholine metabolic process&apos; SubClassOf &apos;positive regulation of hormone metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0060410</classIRI>
<classLabel>negative regulation of acetylcholine metabolic process</classLabel>
<newAxiom>&apos;negative regulation of acetylcholine metabolic process&apos; SubClassOf &apos;negative regulation of hormone metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072390</classIRI>
<classLabel>phenol metabolic process</classLabel>
<newAxiom>&apos;phenol metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0072392</classIRI>
<classLabel>phenol catabolic process</classLabel>
<newAxiom>&apos;phenol catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0035349</classIRI>
<classLabel>coenzyme A transmembrane transport</classLabel>
<deletedAxiom>&apos;coenzyme A transmembrane transport&apos; SubClassOf &apos;organic anion transport&apos;</deletedAxiom>
<newAxiom>&apos;coenzyme A transmembrane transport&apos; SubClassOf &apos;coenzyme A transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0035350</classIRI>
<classLabel>FAD transmembrane transport</classLabel>
<newAxiom>&apos;FAD transmembrane transport&apos; SubClassOf &apos;cofactor transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0035348</classIRI>
<classLabel>acetyl-CoA transmembrane transport</classLabel>
<deletedAxiom>&apos;acetyl-CoA transmembrane transport&apos; SubClassOf &apos;fatty-acyl-CoA transport&apos;</deletedAxiom>
<newAxiom>&apos;acetyl-CoA transmembrane transport&apos; SubClassOf &apos;acetyl-CoA transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0035378</classIRI>
<classLabel>carbon dioxide transmembrane transport</classLabel>
<deletedAxiom>&apos;carbon dioxide transmembrane transport&apos; SubClassOf &apos;transmembrane transport&apos;</deletedAxiom>
<newAxiom>&apos;carbon dioxide transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0035379</classIRI>
<classLabel>carbon dioxide transmembrane transporter activity</classLabel>
<deletedAxiom>&apos;carbon dioxide transmembrane transporter activity&apos; SubClassOf &apos;transmembrane transporter activity&apos;</deletedAxiom>
<newAxiom>&apos;carbon dioxide transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0001975</classIRI>
<classLabel>response to amphetamine</classLabel>
<newAxiom>&apos;response to amphetamine&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
<newAxiom>&apos;response to amphetamine&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
<newAxiom>&apos;response to amphetamine&apos; SubClassOf &apos;response to bronchodilator&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905092</classIRI>
<classLabel>response to diosgenin</classLabel>
<newAxiom>&apos;response to diosgenin&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905093</classIRI>
<classLabel>cellular response to diosgenin</classLabel>
<newAxiom>&apos;cellular response to diosgenin&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0050804</classIRI>
<classLabel>modulation of chemical synaptic transmission</classLabel>
<deletedAxiom>&apos;modulation of chemical synaptic transmission&apos; SubClassOf &apos;regulation of cell communication&apos;</deletedAxiom>
<deletedAxiom>&apos;modulation of chemical synaptic transmission&apos; SubClassOf &apos;regulation of signaling&apos;</deletedAxiom>
<newAxiom>&apos;modulation of chemical synaptic transmission&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099177</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0106064</classIRI>
<classLabel>regulation of cobalamin metabolic process</classLabel>
<newAxiom>&apos;regulation of cobalamin metabolic process&apos; SubClassOf &apos;regulation of cofactor metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0050843</classIRI>
<classLabel>S-adenosylmethionine catabolic process</classLabel>
<newAxiom>&apos;S-adenosylmethionine catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0035240</classIRI>
<classLabel>dopamine binding</classLabel>
<newAxiom>&apos;dopamine binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0035275</classIRI>
<classLabel>dibutyl phthalate binding</classLabel>
<newAxiom>&apos;dibutyl phthalate binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0035276</classIRI>
<classLabel>ethanol binding</classLabel>
<newAxiom>&apos;ethanol binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0035274</classIRI>
<classLabel>diphenyl phthalate binding</classLabel>
<newAxiom>&apos;diphenyl phthalate binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905010</classIRI>
<classLabel>positive regulation of L-lysine import across plasma membrane</classLabel>
<newAxiom>&apos;positive regulation of L-lysine import across plasma membrane&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905009</classIRI>
<classLabel>negative regulation of L-lysine import across plasma membrane</classLabel>
<newAxiom>&apos;negative regulation of L-lysine import across plasma membrane&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905008</classIRI>
<classLabel>regulation of L-lysine import across plasma membrane</classLabel>
<newAxiom>&apos;regulation of L-lysine import across plasma membrane&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0098712</classIRI>
<classLabel>L-glutamate import across plasma membrane</classLabel>
<newAxiom>&apos;L-glutamate import across plasma membrane&apos; SubClassOf &apos;neurotransmitter uptake&apos;</newAxiom>
<newAxiom>&apos;L-glutamate import across plasma membrane&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0098717</classIRI>
<classLabel>pantothenate import across plasma membrane</classLabel>
<newAxiom>&apos;pantothenate import across plasma membrane&apos; SubClassOf &apos;vitamin transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0050783</classIRI>
<classLabel>cocaine metabolic process</classLabel>
<newAxiom>&apos;cocaine metabolic process&apos; SubClassOf &apos;xenobiotic metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0050784</classIRI>
<classLabel>cocaine catabolic process</classLabel>
<newAxiom>&apos;cocaine catabolic process&apos; SubClassOf &apos;xenobiotic catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0035075</classIRI>
<classLabel>response to ecdysone</classLabel>
<newAxiom>&apos;response to ecdysone&apos; SubClassOf &apos;response to hormone&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0098666</classIRI>
<classLabel>G-protein coupled serotonin receptor complex</classLabel>
<newAxiom>&apos;G-protein coupled serotonin receptor complex&apos; SubClassOf &apos;neurotransmitter receptor complex&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0035094</classIRI>
<classLabel>response to nicotine</classLabel>
<deletedAxiom>&apos;response to nicotine&apos; SubClassOf &apos;response to chemical&apos;</deletedAxiom>
<newAxiom>&apos;response to nicotine&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
<newAxiom>&apos;response to nicotine&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0050696</classIRI>
<classLabel>trichloroethylene catabolic process</classLabel>
<newAxiom>&apos;trichloroethylene catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905135</classIRI>
<classLabel>biotin import across plasma membrane</classLabel>
<newAxiom>&apos;biotin import across plasma membrane&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0001762</classIRI>
<classLabel>beta-alanine transport</classLabel>
<newAxiom>&apos;beta-alanine transport&apos; SubClassOf &apos;neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0001761</classIRI>
<classLabel>beta-alanine transmembrane transporter activity</classLabel>
<newAxiom>&apos;beta-alanine transmembrane transporter activity&apos; SubClassOf &apos;neurotransmitter transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905144</classIRI>
<classLabel>response to acetylcholine</classLabel>
<deletedAxiom>&apos;response to acetylcholine&apos; SubClassOf &apos;response to organic substance&apos;</deletedAxiom>
<newAxiom>&apos;response to acetylcholine&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
<newAxiom>&apos;response to acetylcholine&apos; SubClassOf &apos;response to hormone&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905145</classIRI>
<classLabel>cellular response to acetylcholine</classLabel>
<newAxiom>&apos;cellular response to acetylcholine&apos; SubClassOf &apos;cellular response to hormone stimulus&apos;</newAxiom>
<newAxiom>&apos;cellular response to acetylcholine&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905119</classIRI>
<classLabel>response to haloperidol</classLabel>
<newAxiom>&apos;response to haloperidol&apos; SubClassOf &apos;response to antipsychotic drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905120</classIRI>
<classLabel>cellular response to haloperidol</classLabel>
<newAxiom>&apos;cellular response to haloperidol&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0050665</classIRI>
<classLabel>hydrogen peroxide biosynthetic process</classLabel>
<deletedAxiom>&apos;hydrogen peroxide biosynthetic process&apos; SubClassOf &apos;cellular biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;hydrogen peroxide biosynthetic process&apos; SubClassOf &apos;cofactor biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0050646</classIRI>
<classLabel>5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding</classLabel>
<newAxiom>&apos;5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0001694</classIRI>
<classLabel>histamine biosynthetic process</classLabel>
<newAxiom>&apos;histamine biosynthetic process&apos; SubClassOf &apos;neurotransmitter biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0001692</classIRI>
<classLabel>histamine metabolic process</classLabel>
<newAxiom>&apos;histamine metabolic process&apos; SubClassOf &apos;neurotransmitter metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905218</classIRI>
<classLabel>cellular response to astaxanthin</classLabel>
<newAxiom>&apos;cellular response to astaxanthin&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905217</classIRI>
<classLabel>response to astaxanthin</classLabel>
<newAxiom>&apos;response to astaxanthin&apos; SubClassOf &apos;response to anticoagulant&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905200</classIRI>
<classLabel>gibberellic acid transmembrane transport</classLabel>
<newAxiom>&apos;gibberellic acid transmembrane transport&apos; SubClassOf &apos;hormone transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905206</classIRI>
<classLabel>positive regulation of hydrogen peroxide-induced cell death</classLabel>
<newAxiom>&apos;positive regulation of hydrogen peroxide-induced cell death&apos; SubClassOf &apos;positive regulation of cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905232</classIRI>
<classLabel>cellular response to L-glutamate</classLabel>
<newAxiom>&apos;cellular response to L-glutamate&apos; SubClassOf &apos;cellular response to nutrient&apos;</newAxiom>
<newAxiom>&apos;cellular response to L-glutamate&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905233</classIRI>
<classLabel>response to codeine</classLabel>
<newAxiom>&apos;response to codeine&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
<newAxiom>&apos;response to codeine&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905236</classIRI>
<classLabel>cellular response to quercetin</classLabel>
<newAxiom>&apos;cellular response to quercetin&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to quercetin&apos; SubClassOf &apos;cellular response to hormone stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905237</classIRI>
<classLabel>response to cyclosporin A</classLabel>
<newAxiom>&apos;response to cyclosporin A&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905234</classIRI>
<classLabel>cellular response to codeine</classLabel>
<newAxiom>&apos;cellular response to codeine&apos; SubClassOf &apos;cellular response to xenobiotic stimulus&apos;</newAxiom>
<newAxiom>&apos;cellular response to codeine&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905235</classIRI>
<classLabel>response to quercetin</classLabel>
<newAxiom>&apos;response to quercetin&apos; SubClassOf &apos;response to hormone&apos;</newAxiom>
<newAxiom>&apos;response to quercetin&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905238</classIRI>
<classLabel>cellular response to cyclosporin A</classLabel>
<newAxiom>&apos;cellular response to cyclosporin A&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905243</classIRI>
<classLabel>cellular response to 3,3&apos;,5-triiodo-L-thyronine</classLabel>
<newAxiom>&apos;cellular response to 3,3&apos;,5-triiodo-L-thyronine&apos; SubClassOf &apos;cellular response to thyroid hormone stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905242</classIRI>
<classLabel>response to 3,3&apos;,5-triiodo-L-thyronine</classLabel>
<newAxiom>&apos;response to 3,3&apos;,5-triiodo-L-thyronine&apos; SubClassOf &apos;response to thyroid hormone&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905307</classIRI>
<classLabel>response to miconazole</classLabel>
<newAxiom>&apos;response to miconazole&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905308</classIRI>
<classLabel>cellular response to miconazole</classLabel>
<newAxiom>&apos;cellular response to miconazole&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905429</classIRI>
<classLabel>response to glycine</classLabel>
<newAxiom>&apos;response to glycine&apos; SubClassOf &apos;response to nutrient&apos;</newAxiom>
<newAxiom>&apos;response to glycine&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905409</classIRI>
<classLabel>positive regulation of creatine transmembrane transporter activity</classLabel>
<newAxiom>&apos;positive regulation of creatine transmembrane transporter activity&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905407</classIRI>
<classLabel>regulation of creatine transmembrane transporter activity</classLabel>
<newAxiom>&apos;regulation of creatine transmembrane transporter activity&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905408</classIRI>
<classLabel>negative regulation of creatine transmembrane transporter activity</classLabel>
<newAxiom>&apos;negative regulation of creatine transmembrane transporter activity&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905430</classIRI>
<classLabel>cellular response to glycine</classLabel>
<newAxiom>&apos;cellular response to glycine&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to glycine&apos; SubClassOf &apos;cellular response to nutrient&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905431</classIRI>
<classLabel>microcystin transport</classLabel>
<newAxiom>&apos;microcystin transport&apos; SubClassOf &apos;toxin transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905432</classIRI>
<classLabel>regulation of retrograde trans-synaptic signaling by neuropeptide</classLabel>
<deletedAxiom>&apos;regulation of retrograde trans-synaptic signaling by neuropeptide&apos; SubClassOf &apos;regulation of signaling&apos;</deletedAxiom>
<deletedAxiom>&apos;regulation of retrograde trans-synaptic signaling by neuropeptide&apos; SubClassOf &apos;regulation of cell communication&apos;</deletedAxiom>
<newAxiom>&apos;regulation of retrograde trans-synaptic signaling by neuropeptide&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099177</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015906</classIRI>
<classLabel>sulfathiazole transport</classLabel>
<newAxiom>&apos;sulfathiazole transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
<newAxiom>&apos;sulfathiazole transport&apos; SubClassOf &apos;xenobiotic transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015903</classIRI>
<classLabel>fluconazole transport</classLabel>
<newAxiom>&apos;fluconazole transport&apos; SubClassOf &apos;xenobiotic transport&apos;</newAxiom>
<newAxiom>&apos;fluconazole transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015942</classIRI>
<classLabel>formate metabolic process</classLabel>
<newAxiom>&apos;formate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905502</classIRI>
<classLabel>acetyl-CoA binding</classLabel>
<newAxiom>&apos;acetyl-CoA binding&apos; SubClassOf &apos;coenzyme binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905530</classIRI>
<classLabel>negative regulation of uracil import across plasma membrane</classLabel>
<newAxiom>&apos;negative regulation of uracil import across plasma membrane&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905531</classIRI>
<classLabel>positive regulation of uracil import across plasma membrane</classLabel>
<newAxiom>&apos;positive regulation of uracil import across plasma membrane&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905544</classIRI>
<classLabel>L-methionine import across plasma membrane</classLabel>
<newAxiom>&apos;L-methionine import across plasma membrane&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905542</classIRI>
<classLabel>negative regulation of L-arginine import across plasma membrane</classLabel>
<newAxiom>&apos;negative regulation of L-arginine import across plasma membrane&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905529</classIRI>
<classLabel>regulation of uracil import across plasma membrane</classLabel>
<newAxiom>&apos;regulation of uracil import across plasma membrane&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903091</classIRI>
<classLabel>pyridoxamine transmembrane transport</classLabel>
<newAxiom>&apos;pyridoxamine transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903090</classIRI>
<classLabel>pyridoxal transmembrane transport</classLabel>
<newAxiom>&apos;pyridoxal transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903092</classIRI>
<classLabel>pyridoxine transmembrane transport</classLabel>
<newAxiom>&apos;pyridoxine transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015805</classIRI>
<classLabel>S-adenosyl-L-methionine transport</classLabel>
<newAxiom>&apos;S-adenosyl-L-methionine transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015812</classIRI>
<classLabel>gamma-aminobutyric acid transport</classLabel>
<newAxiom>&apos;gamma-aminobutyric acid transport&apos; SubClassOf &apos;neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015816</classIRI>
<classLabel>glycine transport</classLabel>
<newAxiom>&apos;glycine transport&apos; SubClassOf &apos;neurotransmitter transport&apos;</newAxiom>
<newAxiom>&apos;glycine transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015813</classIRI>
<classLabel>L-glutamate transport</classLabel>
<newAxiom>&apos;L-glutamate transport&apos; SubClassOf &apos;neurotransmitter transport&apos;</newAxiom>
<newAxiom>&apos;L-glutamate transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015857</classIRI>
<classLabel>uracil transport</classLabel>
<newAxiom>&apos;uracil transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015867</classIRI>
<classLabel>ATP transport</classLabel>
<newAxiom>&apos;ATP transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015877</classIRI>
<classLabel>biopterin transport</classLabel>
<deletedAxiom>&apos;biopterin transport&apos; SubClassOf &apos;cofactor transport&apos;</deletedAxiom>
<newAxiom>&apos;biopterin transport&apos; SubClassOf &apos;coenzyme transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015878</classIRI>
<classLabel>biotin transport</classLabel>
<deletedAxiom>&apos;biotin transport&apos; SubClassOf &apos;cofactor transport&apos;</deletedAxiom>
<newAxiom>&apos;biotin transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
<newAxiom>&apos;biotin transport&apos; SubClassOf &apos;coenzyme transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015871</classIRI>
<classLabel>choline transport</classLabel>
<newAxiom>&apos;choline transport&apos; SubClassOf &apos;neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015872</classIRI>
<classLabel>dopamine transport</classLabel>
<newAxiom>&apos;dopamine transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015870</classIRI>
<classLabel>acetylcholine transport</classLabel>
<newAxiom>&apos;acetylcholine transport&apos; SubClassOf &apos;hormone transport&apos;</newAxiom>
<newAxiom>&apos;acetylcholine transport&apos; SubClassOf &apos;neurotransmitter transport&apos;</newAxiom>
<newAxiom>&apos;acetylcholine transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015888</classIRI>
<classLabel>thiamine transport</classLabel>
<newAxiom>&apos;thiamine transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015889</classIRI>
<classLabel>cobalamin transport</classLabel>
<newAxiom>&apos;cobalamin transport&apos; SubClassOf &apos;cofactor transport&apos;</newAxiom>
<newAxiom>&apos;cobalamin transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015884</classIRI>
<classLabel>folic acid transport</classLabel>
<newAxiom>&apos;folic acid transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015882</classIRI>
<classLabel>L-ascorbic acid transport</classLabel>
<newAxiom>&apos;L-ascorbic acid transport&apos; SubClassOf &apos;coenzyme transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015881</classIRI>
<classLabel>creatine transport</classLabel>
<newAxiom>&apos;creatine transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015891</classIRI>
<classLabel>siderophore transport</classLabel>
<newAxiom>&apos;siderophore transport&apos; SubClassOf &apos;cofactor transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905705</classIRI>
<classLabel>cellular response to paclitaxel</classLabel>
<newAxiom>&apos;cellular response to paclitaxel&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905625</classIRI>
<classLabel>negative regulation of L-methionine import across plasma membrane</classLabel>
<newAxiom>&apos;negative regulation of L-methionine import across plasma membrane&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905626</classIRI>
<classLabel>positive regulation of L-methionine import across plasma membrane</classLabel>
<newAxiom>&apos;positive regulation of L-methionine import across plasma membrane&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905624</classIRI>
<classLabel>regulation of L-methionine import across plasma membrane</classLabel>
<newAxiom>&apos;regulation of L-methionine import across plasma membrane&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905627</classIRI>
<classLabel>regulation of serotonin biosynthetic process</classLabel>
<newAxiom>&apos;regulation of serotonin biosynthetic process&apos; SubClassOf &apos;regulation of neurotransmitter levels&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1905606</classIRI>
<classLabel>regulation of presynapse assembly</classLabel>
<newAxiom>&apos;regulation of presynapse assembly&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099174</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903088</classIRI>
<classLabel>5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport</classLabel>
<deletedAxiom>&apos;5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport&apos; SubClassOf &apos;transmembrane transport&apos;</deletedAxiom>
<newAxiom>&apos;5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1903089</classIRI>
<classLabel>5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity</classLabel>
<newAxiom>&apos;5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015724</classIRI>
<classLabel>formate transport</classLabel>
<newAxiom>&apos;formate transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015722</classIRI>
<classLabel>canalicular bile acid transport</classLabel>
<deletedAxiom>&apos;canalicular bile acid transport&apos; SubClassOf &apos;bile acid secretion&apos;</deletedAxiom>
<newAxiom>&apos;canalicular bile acid transport&apos; SubClassOf &apos;acid secretion&apos;</newAxiom>
<newAxiom>&apos;canalicular bile acid transport&apos; SubClassOf &apos;bile acid and bile salt transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015720</classIRI>
<classLabel>allantoin transport</classLabel>
<newAxiom>&apos;allantoin transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015734</classIRI>
<classLabel>taurine transport</classLabel>
<newAxiom>&apos;taurine transport&apos; SubClassOf &apos;organic acid transport&apos;</newAxiom>
<newAxiom>&apos;taurine transport&apos; SubClassOf &apos;xenobiotic transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015730</classIRI>
<classLabel>propanoate transport</classLabel>
<newAxiom>&apos;propanoate transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015744</classIRI>
<classLabel>succinate transport</classLabel>
<newAxiom>&apos;succinate transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015742</classIRI>
<classLabel>alpha-ketoglutarate transport</classLabel>
<newAxiom>&apos;alpha-ketoglutarate transport&apos; SubClassOf &apos;cofactor transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0052649</classIRI>
<classLabel>coenzyme gamma-F420-2 metabolic process</classLabel>
<newAxiom>&apos;coenzyme gamma-F420-2 metabolic process&apos; SubClassOf &apos;coenzyme metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904400</classIRI>
<classLabel>response to Thyroid stimulating hormone</classLabel>
<deletedAxiom>&apos;response to Thyroid stimulating hormone&apos; SubClassOf &apos;response to organic substance&apos;</deletedAxiom>
<newAxiom>&apos;response to Thyroid stimulating hormone&apos; SubClassOf &apos;response to glycoprotein&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904401</classIRI>
<classLabel>cellular response to Thyroid stimulating hormone</classLabel>
<deletedAxiom>&apos;cellular response to Thyroid stimulating hormone&apos; SubClassOf &apos;cellular response to chemical stimulus&apos;</deletedAxiom>
<newAxiom>&apos;cellular response to Thyroid stimulating hormone&apos; SubClassOf &apos;cellular response to glycoprotein&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904402</classIRI>
<classLabel>response to nocodazole</classLabel>
<newAxiom>&apos;response to nocodazole&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904403</classIRI>
<classLabel>cellular response to nocodazole</classLabel>
<newAxiom>&apos;cellular response to nocodazole&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904408</classIRI>
<classLabel>melatonin binding</classLabel>
<newAxiom>&apos;melatonin binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
<newAxiom>&apos;melatonin binding&apos; SubClassOf &apos;hormone binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904406</classIRI>
<classLabel>negative regulation of nitric oxide metabolic process</classLabel>
<newAxiom>&apos;negative regulation of nitric oxide metabolic process&apos; SubClassOf &apos;regulation of neurotransmitter levels&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904407</classIRI>
<classLabel>positive regulation of nitric oxide metabolic process</classLabel>
<newAxiom>&apos;positive regulation of nitric oxide metabolic process&apos; SubClassOf &apos;regulation of neurotransmitter levels&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0052653</classIRI>
<classLabel>3&apos;,5&apos;-cyclic diguanylic acid metabolic process</classLabel>
<newAxiom>&apos;3&apos;,5&apos;-cyclic diguanylic acid metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904447</classIRI>
<classLabel>folic acid import across plasma membrane</classLabel>
<newAxiom>&apos;folic acid import across plasma membrane&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904486</classIRI>
<classLabel>response to 17alpha-ethynylestradiol</classLabel>
<newAxiom>&apos;response to 17alpha-ethynylestradiol&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
<newAxiom>&apos;response to 17alpha-ethynylestradiol&apos; SubClassOf &apos;response to hormone&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904487</classIRI>
<classLabel>cellular response to 17alpha-ethynylestradiol</classLabel>
<newAxiom>&apos;cellular response to 17alpha-ethynylestradiol&apos; SubClassOf &apos;cellular response to hormone stimulus&apos;</newAxiom>
<newAxiom>&apos;cellular response to 17alpha-ethynylestradiol&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904473</classIRI>
<classLabel>response to L-dopa</classLabel>
<newAxiom>&apos;response to L-dopa&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
<newAxiom>&apos;response to L-dopa&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904474</classIRI>
<classLabel>cellular response to L-dopa</classLabel>
<newAxiom>&apos;cellular response to L-dopa&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to L-dopa&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1990544</classIRI>
<classLabel>mitochondrial ATP transmembrane transport</classLabel>
<newAxiom>&apos;mitochondrial ATP transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1990543</classIRI>
<classLabel>mitochondrial S-adenosyl-L-methionine transmembrane transport</classLabel>
<deletedAxiom>&apos;mitochondrial S-adenosyl-L-methionine transmembrane transport&apos; SubClassOf &apos;sulfur compound transport&apos;</deletedAxiom>
<deletedAxiom>&apos;mitochondrial S-adenosyl-L-methionine transmembrane transport&apos; SubClassOf &apos;organic substance transport&apos;</deletedAxiom>
<newAxiom>&apos;mitochondrial S-adenosyl-L-methionine transmembrane transport&apos; SubClassOf &apos;S-adenosyl-L-methionine transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904610</classIRI>
<classLabel>response to 3,3&apos;,4,4&apos;,5-pentachlorobiphenyl</classLabel>
<newAxiom>&apos;response to 3,3&apos;,4,4&apos;,5-pentachlorobiphenyl&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904613</classIRI>
<classLabel>cellular response to 2,3,7,8-tetrachlorodibenzodioxine</classLabel>
<newAxiom>&apos;cellular response to 2,3,7,8-tetrachlorodibenzodioxine&apos; SubClassOf &apos;cellular response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904614</classIRI>
<classLabel>response to biphenyl</classLabel>
<newAxiom>&apos;response to biphenyl&apos; SubClassOf &apos;response to fungicide&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904611</classIRI>
<classLabel>cellular response to 3,3&apos;,4,4&apos;,5-pentachlorobiphenyl</classLabel>
<newAxiom>&apos;cellular response to 3,3&apos;,4,4&apos;,5-pentachlorobiphenyl&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904612</classIRI>
<classLabel>response to 2,3,7,8-tetrachlorodibenzodioxine</classLabel>
<newAxiom>&apos;response to 2,3,7,8-tetrachlorodibenzodioxine&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015671</classIRI>
<classLabel>oxygen transport</classLabel>
<newAxiom>&apos;oxygen transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904615</classIRI>
<classLabel>cellular response to biphenyl</classLabel>
<newAxiom>&apos;cellular response to biphenyl&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015670</classIRI>
<classLabel>carbon dioxide transport</classLabel>
<newAxiom>&apos;carbon dioxide transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904619</classIRI>
<classLabel>response to dimethyl sulfoxide</classLabel>
<newAxiom>&apos;response to dimethyl sulfoxide&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904561</classIRI>
<classLabel>cellular response to diphenidol</classLabel>
<newAxiom>&apos;cellular response to diphenidol&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904560</classIRI>
<classLabel>response to diphenidol</classLabel>
<newAxiom>&apos;response to diphenidol&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904555</classIRI>
<classLabel>L-proline transmembrane transport</classLabel>
<newAxiom>&apos;L-proline transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904558</classIRI>
<classLabel>response to dextromethorphan</classLabel>
<newAxiom>&apos;response to dextromethorphan&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
<newAxiom>&apos;response to dextromethorphan&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
<newAxiom>&apos;response to dextromethorphan&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904559</classIRI>
<classLabel>cellular response to dextromethorphan</classLabel>
<newAxiom>&apos;cellular response to dextromethorphan&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to dextromethorphan&apos; SubClassOf &apos;cellular response to xenobiotic stimulus&apos;</newAxiom>
<newAxiom>&apos;cellular response to dextromethorphan&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904556</classIRI>
<classLabel>L-tryptophan transmembrane transport</classLabel>
<newAxiom>&apos;L-tryptophan transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015546</classIRI>
<classLabel>sulfathiazole transmembrane transporter activity</classLabel>
<newAxiom>&apos;sulfathiazole transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
<newAxiom>&apos;sulfathiazole transmembrane transporter activity&apos; SubClassOf &apos;xenobiotic transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015552</classIRI>
<classLabel>propionate transmembrane transporter activity</classLabel>
<newAxiom>&apos;propionate transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904643</classIRI>
<classLabel>response to curcumin</classLabel>
<newAxiom>&apos;response to curcumin&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904647</classIRI>
<classLabel>response to rotenone</classLabel>
<newAxiom>&apos;response to rotenone&apos; SubClassOf &apos;response to insecticide&apos;</newAxiom>
<newAxiom>&apos;response to rotenone&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904644</classIRI>
<classLabel>cellular response to curcumin</classLabel>
<newAxiom>&apos;cellular response to curcumin&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904648</classIRI>
<classLabel>cellular response to rotenone</classLabel>
<newAxiom>&apos;cellular response to rotenone&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
<newAxiom>&apos;cellular response to rotenone&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904620</classIRI>
<classLabel>cellular response to dimethyl sulfoxide</classLabel>
<deletedAxiom>&apos;cellular response to dimethyl sulfoxide&apos; SubClassOf &apos;cellular response to chemical stimulus&apos;</deletedAxiom>
<newAxiom>&apos;cellular response to dimethyl sulfoxide&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904624</classIRI>
<classLabel>regulation of glycine secretion, neurotransmission</classLabel>
<newAxiom>&apos;regulation of glycine secretion, neurotransmission&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904625</classIRI>
<classLabel>negative regulation of glycine secretion, neurotransmission</classLabel>
<newAxiom>&apos;negative regulation of glycine secretion, neurotransmission&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904628</classIRI>
<classLabel>cellular response to phorbol 13-acetate 12-myristate</classLabel>
<newAxiom>&apos;cellular response to phorbol 13-acetate 12-myristate&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904626</classIRI>
<classLabel>positive regulation of glycine secretion, neurotransmission</classLabel>
<newAxiom>&apos;positive regulation of glycine secretion, neurotransmission&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904627</classIRI>
<classLabel>response to phorbol 13-acetate 12-myristate</classLabel>
<newAxiom>&apos;response to phorbol 13-acetate 12-myristate&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015499</classIRI>
<classLabel>formate transmembrane transporter activity</classLabel>
<newAxiom>&apos;formate transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015498</classIRI>
<classLabel>pantothenate:sodium symporter activity</classLabel>
<newAxiom>&apos;pantothenate:sodium symporter activity&apos; SubClassOf &apos;vitamin transmembrane transporter activity&apos;</newAxiom>
<newAxiom>&apos;pantothenate:sodium symporter activity&apos; SubClassOf &apos;cofactor transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904639</classIRI>
<classLabel>cellular response to resveratrol</classLabel>
<newAxiom>&apos;cellular response to resveratrol&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904638</classIRI>
<classLabel>response to resveratrol</classLabel>
<newAxiom>&apos;response to resveratrol&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902023</classIRI>
<classLabel>L-arginine transport</classLabel>
<newAxiom>&apos;L-arginine transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902022</classIRI>
<classLabel>L-lysine transport</classLabel>
<newAxiom>&apos;L-lysine transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902024</classIRI>
<classLabel>L-histidine transport</classLabel>
<newAxiom>&apos;L-histidine transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904669</classIRI>
<classLabel>ATP export</classLabel>
<newAxiom>&apos;ATP export&apos; SubClassOf &apos;drug export&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902065</classIRI>
<classLabel>response to L-glutamate</classLabel>
<newAxiom>&apos;response to L-glutamate&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
<newAxiom>&apos;response to L-glutamate&apos; SubClassOf &apos;response to nutrient&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902066</classIRI>
<classLabel>regulation of cell wall pectin metabolic process</classLabel>
<newAxiom>&apos;regulation of cell wall pectin metabolic process&apos; SubClassOf &apos;regulation of cellular metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902049</classIRI>
<classLabel>neosartoricin catabolic process</classLabel>
<newAxiom>&apos;neosartoricin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902048</classIRI>
<classLabel>neosartoricin metabolic process</classLabel>
<newAxiom>&apos;neosartoricin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902056</classIRI>
<classLabel>(25S)-Delta(7)-dafachronate metabolic process</classLabel>
<newAxiom>&apos;(25S)-Delta(7)-dafachronate metabolic process&apos; SubClassOf &apos;hormone metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902057</classIRI>
<classLabel>(25S)-Delta(4)-dafachronate metabolic process</classLabel>
<newAxiom>&apos;(25S)-Delta(4)-dafachronate metabolic process&apos; SubClassOf &apos;hormone metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902085</classIRI>
<classLabel>fumagillin catabolic process</classLabel>
<newAxiom>&apos;fumagillin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902084</classIRI>
<classLabel>fumagillin metabolic process</classLabel>
<newAxiom>&apos;fumagillin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902098</classIRI>
<classLabel>calcitriol binding</classLabel>
<newAxiom>&apos;calcitriol binding&apos; SubClassOf &apos;hormone binding&apos;</newAxiom>
<newAxiom>&apos;calcitriol binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904804</classIRI>
<classLabel>response to latrunculin A</classLabel>
<newAxiom>&apos;response to latrunculin A&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904805</classIRI>
<classLabel>cellular response to latrunculin A</classLabel>
<newAxiom>&apos;cellular response to latrunculin A&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015411</classIRI>
<classLabel>taurine-transporting ATPase activity</classLabel>
<newAxiom>&apos;taurine-transporting ATPase activity&apos; SubClassOf &apos;organic acid-transporting ATPase activity&apos;</newAxiom>
<newAxiom>&apos;taurine-transporting ATPase activity&apos; SubClassOf &apos;xenobiotic transmembrane transporting ATPase activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904844</classIRI>
<classLabel>response to L-glutamine</classLabel>
<newAxiom>&apos;response to L-glutamine&apos; SubClassOf &apos;response to nutrient&apos;</newAxiom>
<newAxiom>&apos;response to L-glutamine&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904845</classIRI>
<classLabel>cellular response to L-glutamine</classLabel>
<newAxiom>&apos;cellular response to L-glutamine&apos; SubClassOf &apos;cellular response to nutrient&apos;</newAxiom>
<newAxiom>&apos;cellular response to L-glutamine&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015420</classIRI>
<classLabel>cobalamin-transporting ATPase activity</classLabel>
<newAxiom>&apos;cobalamin-transporting ATPase activity&apos; SubClassOf &apos;cofactor transmembrane transporter activity&apos;</newAxiom>
<newAxiom>&apos;cobalamin-transporting ATPase activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904842</classIRI>
<classLabel>response to nitroglycerin</classLabel>
<newAxiom>&apos;response to nitroglycerin&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904843</classIRI>
<classLabel>cellular response to nitroglycerin</classLabel>
<newAxiom>&apos;cellular response to nitroglycerin&apos; SubClassOf &apos;cellular response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904826</classIRI>
<classLabel>regulation of hydrogen sulfide biosynthetic process</classLabel>
<newAxiom>&apos;regulation of hydrogen sulfide biosynthetic process&apos; SubClassOf &apos;regulation of secondary metabolite biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904827</classIRI>
<classLabel>negative regulation of hydrogen sulfide biosynthetic process</classLabel>
<newAxiom>&apos;negative regulation of hydrogen sulfide biosynthetic process&apos; SubClassOf &apos;negative regulation of secondary metabolite biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904828</classIRI>
<classLabel>positive regulation of hydrogen sulfide biosynthetic process</classLabel>
<newAxiom>&apos;positive regulation of hydrogen sulfide biosynthetic process&apos; SubClassOf &apos;positive regulation of secondary metabolite biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0030975</classIRI>
<classLabel>thiamine binding</classLabel>
<newAxiom>&apos;thiamine binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0030977</classIRI>
<classLabel>taurine binding</classLabel>
<newAxiom>&apos;taurine binding&apos; SubClassOf &apos;organic acid binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015343</classIRI>
<classLabel>siderophore transmembrane transporter activity</classLabel>
<deletedAxiom>&apos;siderophore transmembrane transporter activity&apos; SubClassOf &apos;transmembrane transporter activity&apos;</deletedAxiom>
<newAxiom>&apos;siderophore transmembrane transporter activity&apos; SubClassOf &apos;cofactor transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042950</classIRI>
<classLabel>salicin transmembrane transporter activity</classLabel>
<newAxiom>&apos;salicin transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042945</classIRI>
<classLabel>D-serine transmembrane transporter activity</classLabel>
<newAxiom>&apos;D-serine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042942</classIRI>
<classLabel>D-serine transport</classLabel>
<newAxiom>&apos;D-serine transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902118</classIRI>
<classLabel>calcidiol binding</classLabel>
<newAxiom>&apos;calcidiol binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042948</classIRI>
<classLabel>salicin transport</classLabel>
<newAxiom>&apos;salicin transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015375</classIRI>
<classLabel>glycine:sodium symporter activity</classLabel>
<newAxiom>&apos;glycine:sodium symporter activity&apos; SubClassOf &apos;neurotransmitter:sodium symporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902122</classIRI>
<classLabel>chenodeoxycholic acid binding</classLabel>
<newAxiom>&apos;chenodeoxycholic acid binding&apos; SubClassOf &apos;steroid binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902121</classIRI>
<classLabel>lithocholic acid binding</classLabel>
<newAxiom>&apos;lithocholic acid binding&apos; SubClassOf &apos;steroid binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902124</classIRI>
<classLabel>(+)-pinoresinol metabolic process</classLabel>
<newAxiom>&apos;(+)-pinoresinol metabolic process&apos; SubClassOf &apos;hormone metabolic process&apos;</newAxiom>
<newAxiom>&apos;(+)-pinoresinol metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902126</classIRI>
<classLabel>(+)-pinoresinol biosynthetic process</classLabel>
<newAxiom>&apos;(+)-pinoresinol biosynthetic process&apos; SubClassOf &apos;hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902125</classIRI>
<classLabel>(+)-pinoresinol catabolic process</classLabel>
<newAxiom>&apos;(+)-pinoresinol catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
<newAxiom>&apos;(+)-pinoresinol catabolic process&apos; SubClassOf &apos;hormone catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902137</classIRI>
<classLabel>(-)-secoisolariciresinol catabolic process</classLabel>
<newAxiom>&apos;(-)-secoisolariciresinol catabolic process&apos; SubClassOf &apos;hormone catabolic process&apos;</newAxiom>
<newAxiom>&apos;(-)-secoisolariciresinol catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902136</classIRI>
<classLabel>(-)-secoisolariciresinol metabolic process</classLabel>
<newAxiom>&apos;(-)-secoisolariciresinol metabolic process&apos; SubClassOf &apos;hormone metabolic process&apos;</newAxiom>
<newAxiom>&apos;(-)-secoisolariciresinol metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902138</classIRI>
<classLabel>(-)-secoisolariciresinol biosynthetic process</classLabel>
<newAxiom>&apos;(-)-secoisolariciresinol biosynthetic process&apos; SubClassOf &apos;hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902180</classIRI>
<classLabel>verruculogen catabolic process</classLabel>
<newAxiom>&apos;verruculogen catabolic process&apos; SubClassOf &apos;mycotoxin catabolic process&apos;</newAxiom>
<newAxiom>&apos;verruculogen catabolic process&apos; SubClassOf &apos;detoxification of nitrogen compound&apos;</newAxiom>
<newAxiom>&apos;verruculogen catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902181</classIRI>
<classLabel>verruculogen biosynthetic process</classLabel>
<deletedAxiom>&apos;verruculogen biosynthetic process&apos; SubClassOf &apos;secondary metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;verruculogen biosynthetic process&apos; SubClassOf &apos;mycotoxin biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902179</classIRI>
<classLabel>verruculogen metabolic process</classLabel>
<newAxiom>&apos;verruculogen metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
<newAxiom>&apos;verruculogen metabolic process&apos; SubClassOf &apos;mycotoxin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015306</classIRI>
<classLabel>sialate:cation symporter activity</classLabel>
<newAxiom>&apos;sialate:cation symporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042919</classIRI>
<classLabel>benzoate transport</classLabel>
<newAxiom>&apos;benzoate transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042905</classIRI>
<classLabel>9-cis-retinoic acid metabolic process</classLabel>
<newAxiom>&apos;9-cis-retinoic acid metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042935</classIRI>
<classLabel>achromobactin transport</classLabel>
<deletedAxiom>&apos;achromobactin transport&apos; SubClassOf &apos;cofactor transport&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042934</classIRI>
<classLabel>achromobactin transmembrane transporter activity</classLabel>
<deletedAxiom>&apos;achromobactin transmembrane transporter activity&apos; SubClassOf &apos;cofactor transmembrane transporter activity&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2001142</classIRI>
<classLabel>nicotinate transport</classLabel>
<newAxiom>&apos;nicotinate transport&apos; SubClassOf &apos;vitamin transport&apos;</newAxiom>
<newAxiom>&apos;nicotinate transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904947</classIRI>
<classLabel>folic acid import into mitochondrion</classLabel>
<newAxiom>&apos;folic acid import into mitochondrion&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042925</classIRI>
<classLabel>benzoate transmembrane transporter activity</classLabel>
<newAxiom>&apos;benzoate transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904880</classIRI>
<classLabel>response to hydrogen sulfide</classLabel>
<newAxiom>&apos;response to hydrogen sulfide&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
<newAxiom>&apos;response to hydrogen sulfide&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904881</classIRI>
<classLabel>cellular response to hydrogen sulfide</classLabel>
<newAxiom>&apos;cellular response to hydrogen sulfide&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
<newAxiom>&apos;cellular response to hydrogen sulfide&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042836</classIRI>
<classLabel>D-glucarate metabolic process</classLabel>
<newAxiom>&apos;D-glucarate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2001121</classIRI>
<classLabel>coenzyme gamma-F420-2 biosynthetic process</classLabel>
<newAxiom>&apos;coenzyme gamma-F420-2 biosynthetic process&apos; SubClassOf &apos;coenzyme biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015229</classIRI>
<classLabel>L-ascorbic acid transmembrane transporter activity</classLabel>
<newAxiom>&apos;L-ascorbic acid transmembrane transporter activity&apos; SubClassOf &apos;coenzyme transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015224</classIRI>
<classLabel>biopterin transmembrane transporter activity</classLabel>
<deletedAxiom>&apos;biopterin transmembrane transporter activity&apos; SubClassOf &apos;cofactor transmembrane transporter activity&apos;</deletedAxiom>
<newAxiom>&apos;biopterin transmembrane transporter activity&apos; SubClassOf &apos;coenzyme transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015225</classIRI>
<classLabel>biotin transmembrane transporter activity</classLabel>
<deletedAxiom>&apos;biotin transmembrane transporter activity&apos; SubClassOf &apos;cofactor transmembrane transporter activity&apos;</deletedAxiom>
<newAxiom>&apos;biotin transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
<newAxiom>&apos;biotin transmembrane transporter activity&apos; SubClassOf &apos;coenzyme transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902224</classIRI>
<classLabel>ketone body metabolic process</classLabel>
<newAxiom>&apos;ketone body metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015222</classIRI>
<classLabel>serotonin transmembrane transporter activity</classLabel>
<newAxiom>&apos;serotonin transmembrane transporter activity&apos; SubClassOf &apos;neurotransmitter transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015220</classIRI>
<classLabel>choline transmembrane transporter activity</classLabel>
<newAxiom>&apos;choline transmembrane transporter activity&apos; SubClassOf &apos;neurotransmitter transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042838</classIRI>
<classLabel>D-glucarate catabolic process</classLabel>
<newAxiom>&apos;D-glucarate catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2001132</classIRI>
<classLabel>methane biosynthetic process from 3-(methylthio)propionic acid</classLabel>
<newAxiom>&apos;methane biosynthetic process from 3-(methylthio)propionic acid&apos; SubClassOf &apos;toxin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042822</classIRI>
<classLabel>pyridoxal phosphate metabolic process</classLabel>
<deletedAxiom>&apos;pyridoxal phosphate metabolic process&apos; SubClassOf &apos;cofactor metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;pyridoxal phosphate metabolic process&apos; SubClassOf &apos;coenzyme metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042821</classIRI>
<classLabel>pyridoxal biosynthetic process</classLabel>
<newAxiom>&apos;pyridoxal biosynthetic process&apos; SubClassOf &apos;cofactor biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042820</classIRI>
<classLabel>vitamin B6 catabolic process</classLabel>
<newAxiom>&apos;vitamin B6 catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015233</classIRI>
<classLabel>pantothenate transmembrane transporter activity</classLabel>
<newAxiom>&apos;pantothenate transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2001134</classIRI>
<classLabel>methane biosynthetic process from carbon monoxide</classLabel>
<newAxiom>&apos;methane biosynthetic process from carbon monoxide&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
<newAxiom>&apos;methane biosynthetic process from carbon monoxide&apos; SubClassOf &apos;neurotransmitter metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015234</classIRI>
<classLabel>thiamine transmembrane transporter activity</classLabel>
<newAxiom>&apos;thiamine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015244</classIRI>
<classLabel>fluconazole transmembrane transporter activity</classLabel>
<newAxiom>&apos;fluconazole transmembrane transporter activity&apos; SubClassOf &apos;xenobiotic transmembrane transporter activity&apos;</newAxiom>
<newAxiom>&apos;fluconazole transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042878</classIRI>
<classLabel>D-glucarate transmembrane transporter activity</classLabel>
<newAxiom>&apos;D-glucarate transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042870</classIRI>
<classLabel>D-glucarate transport</classLabel>
<newAxiom>&apos;D-glucarate transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902270</classIRI>
<classLabel>(R)-carnitine transmembrane transport</classLabel>
<newAxiom>&apos;(R)-carnitine transmembrane transport&apos; SubClassOf &apos;vitamin transmembrane transport&apos;</newAxiom>
<newAxiom>&apos;(R)-carnitine transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902272</classIRI>
<classLabel>regulation of (R)-carnitine transmembrane transport</classLabel>
<newAxiom>&apos;regulation of (R)-carnitine transmembrane transport&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902274</classIRI>
<classLabel>positive regulation of (R)-carnitine transmembrane transport</classLabel>
<newAxiom>&apos;positive regulation of (R)-carnitine transmembrane transport&apos; SubClassOf &apos;positive regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902273</classIRI>
<classLabel>negative regulation of (R)-carnitine transmembrane transport</classLabel>
<newAxiom>&apos;negative regulation of (R)-carnitine transmembrane transport&apos; SubClassOf &apos;negative regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042895</classIRI>
<classLabel>antibiotic transmembrane transporter activity</classLabel>
<newAxiom>&apos;antibiotic transmembrane transporter activity&apos; SubClassOf &apos;toxin transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042891</classIRI>
<classLabel>antibiotic transport</classLabel>
<newAxiom>&apos;antibiotic transport&apos; SubClassOf &apos;toxin transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1990818</classIRI>
<classLabel>L-arginine transmembrane export from vacuole</classLabel>
<newAxiom>&apos;L-arginine transmembrane export from vacuole&apos; SubClassOf &apos;drug transmembrane export&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2001063</classIRI>
<classLabel>glucomannan binding</classLabel>
<newAxiom>&apos;glucomannan binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042817</classIRI>
<classLabel>pyridoxal metabolic process</classLabel>
<newAxiom>&apos;pyridoxal metabolic process&apos; SubClassOf &apos;cofactor metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042816</classIRI>
<classLabel>vitamin B6 metabolic process</classLabel>
<newAxiom>&apos;vitamin B6 metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015210</classIRI>
<classLabel>uracil transmembrane transporter activity</classLabel>
<newAxiom>&apos;uracil transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2001004</classIRI>
<classLabel>negative regulation of pectin catabolic process</classLabel>
<deletedAxiom>&apos;negative regulation of pectin catabolic process&apos; SubClassOf &apos;negative regulation of catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;negative regulation of pectin catabolic process&apos; SubClassOf &apos;negative regulation of cellular catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902348</classIRI>
<classLabel>cellular response to strigolactone</classLabel>
<newAxiom>&apos;cellular response to strigolactone&apos; SubClassOf &apos;cellular response to hormone stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902347</classIRI>
<classLabel>response to strigolactone</classLabel>
<newAxiom>&apos;response to strigolactone&apos; SubClassOf &apos;response to hormone&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902349</classIRI>
<classLabel>response to chloroquine</classLabel>
<newAxiom>&apos;response to chloroquine&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2001005</classIRI>
<classLabel>positive regulation of pectin catabolic process</classLabel>
<deletedAxiom>&apos;positive regulation of pectin catabolic process&apos; SubClassOf &apos;positive regulation of catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;positive regulation of pectin catabolic process&apos; SubClassOf &apos;positive regulation of cellular catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902351</classIRI>
<classLabel>response to imidacloprid</classLabel>
<newAxiom>&apos;response to imidacloprid&apos; SubClassOf &apos;response to insecticide&apos;</newAxiom>
<newAxiom>&apos;response to imidacloprid&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
<newAxiom>&apos;response to imidacloprid&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902350</classIRI>
<classLabel>cellular response to chloroquine</classLabel>
<newAxiom>&apos;cellular response to chloroquine&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042701</classIRI>
<classLabel>progesterone secretion</classLabel>
<newAxiom>&apos;progesterone secretion&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1904983</classIRI>
<classLabel>transmembrane glycine transport from cytosol to mitochondrion</classLabel>
<newAxiom>&apos;transmembrane glycine transport from cytosol to mitochondrion&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042725</classIRI>
<classLabel>thiamine-containing compound catabolic process</classLabel>
<newAxiom>&apos;thiamine-containing compound catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042723</classIRI>
<classLabel>thiamine-containing compound metabolic process</classLabel>
<newAxiom>&apos;thiamine-containing compound metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015139</classIRI>
<classLabel>alpha-ketoglutarate transmembrane transporter activity</classLabel>
<newAxiom>&apos;alpha-ketoglutarate transmembrane transporter activity&apos; SubClassOf &apos;cofactor transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902384</classIRI>
<classLabel>glycyrrhetinate metabolic process</classLabel>
<newAxiom>&apos;glycyrrhetinate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902385</classIRI>
<classLabel>glycyrrhetinate catabolic process</classLabel>
<newAxiom>&apos;glycyrrhetinate catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015141</classIRI>
<classLabel>succinate transmembrane transporter activity</classLabel>
<newAxiom>&apos;succinate transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042744</classIRI>
<classLabel>hydrogen peroxide catabolic process</classLabel>
<deletedAxiom>&apos;hydrogen peroxide catabolic process&apos; SubClassOf &apos;cellular catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;hydrogen peroxide catabolic process&apos; SubClassOf &apos;cofactor catabolic process&apos;</newAxiom>
<newAxiom>&apos;hydrogen peroxide catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042743</classIRI>
<classLabel>hydrogen peroxide metabolic process</classLabel>
<newAxiom>&apos;hydrogen peroxide metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
<newAxiom>&apos;hydrogen peroxide metabolic process&apos; SubClassOf &apos;cofactor metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015189</classIRI>
<classLabel>L-lysine transmembrane transporter activity</classLabel>
<newAxiom>&apos;L-lysine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015187</classIRI>
<classLabel>glycine transmembrane transporter activity</classLabel>
<newAxiom>&apos;glycine transmembrane transporter activity&apos; SubClassOf &apos;neurotransmitter transporter activity&apos;</newAxiom>
<newAxiom>&apos;glycine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015185</classIRI>
<classLabel>gamma-aminobutyric acid transmembrane transporter activity</classLabel>
<newAxiom>&apos;gamma-aminobutyric acid transmembrane transporter activity&apos; SubClassOf &apos;neurotransmitter transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015186</classIRI>
<classLabel>L-glutamine transmembrane transporter activity</classLabel>
<newAxiom>&apos;L-glutamine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015183</classIRI>
<classLabel>L-aspartate transmembrane transporter activity</classLabel>
<newAxiom>&apos;L-aspartate transmembrane transporter activity&apos; SubClassOf &apos;neurotransmitter transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015182</classIRI>
<classLabel>L-asparagine transmembrane transporter activity</classLabel>
<newAxiom>&apos;L-asparagine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015191</classIRI>
<classLabel>L-methionine transmembrane transporter activity</classLabel>
<newAxiom>&apos;L-methionine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015196</classIRI>
<classLabel>L-tryptophan transmembrane transporter activity</classLabel>
<newAxiom>&apos;L-tryptophan transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015195</classIRI>
<classLabel>L-threonine transmembrane transporter activity</classLabel>
<newAxiom>&apos;L-threonine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015192</classIRI>
<classLabel>L-phenylalanine transmembrane transporter activity</classLabel>
<newAxiom>&apos;L-phenylalanine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0015193</classIRI>
<classLabel>L-proline transmembrane transporter activity</classLabel>
<newAxiom>&apos;L-proline transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0052074</classIRI>
<classLabel>positive regulation by symbiont of host salicylic acid-mediated defense response</classLabel>
<newAxiom>&apos;positive regulation by symbiont of host salicylic acid-mediated defense response&apos; SubClassOf &apos;positive regulation of cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902519</classIRI>
<classLabel>response to docetaxel trihydrate</classLabel>
<deletedAxiom>&apos;response to docetaxel trihydrate&apos; SubClassOf &apos;response to chemical&apos;</deletedAxiom>
<newAxiom>&apos;response to docetaxel trihydrate&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902518</classIRI>
<classLabel>response to cyclophosphamide</classLabel>
<newAxiom>&apos;response to cyclophosphamide&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
<newAxiom>&apos;response to cyclophosphamide&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902522</classIRI>
<classLabel>response to 4&apos;-epidoxorubicin</classLabel>
<newAxiom>&apos;response to 4&apos;-epidoxorubicin&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902521</classIRI>
<classLabel>response to etoposide</classLabel>
<newAxiom>&apos;response to etoposide&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042616</classIRI>
<classLabel>paclitaxel metabolic process</classLabel>
<newAxiom>&apos;paclitaxel metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902444</classIRI>
<classLabel>riboflavin binding</classLabel>
<newAxiom>&apos;riboflavin binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
<newAxiom>&apos;riboflavin binding&apos; SubClassOf &apos;vitamin binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0030652</classIRI>
<classLabel>peptide antibiotic catabolic process</classLabel>
<newAxiom>&apos;peptide antibiotic catabolic process&apos; SubClassOf &apos;detoxification of nitrogen compound&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0030655</classIRI>
<classLabel>beta-lactam antibiotic catabolic process</classLabel>
<newAxiom>&apos;beta-lactam antibiotic catabolic process&apos; SubClassOf &apos;detoxification of nitrogen compound&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2001309</classIRI>
<classLabel>gliotoxin catabolic process</classLabel>
<newAxiom>&apos;gliotoxin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2001308</classIRI>
<classLabel>gliotoxin metabolic process</classLabel>
<newAxiom>&apos;gliotoxin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902497</classIRI>
<classLabel>iron-sulfur cluster transport</classLabel>
<newAxiom>&apos;iron-sulfur cluster transport&apos; SubClassOf &apos;cofactor transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0052004</classIRI>
<classLabel>negative regulation by symbiont of host salicylic acid-mediated defense response</classLabel>
<newAxiom>&apos;negative regulation by symbiont of host salicylic acid-mediated defense response&apos; SubClassOf &apos;negative regulation of cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902670</classIRI>
<classLabel>carbon dioxide binding</classLabel>
<deletedAxiom>&apos;carbon dioxide binding&apos; SubClassOf &apos;binding&apos;</deletedAxiom>
<newAxiom>&apos;carbon dioxide binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2001292</classIRI>
<classLabel>codeine catabolic process</classLabel>
<newAxiom>&apos;codeine catabolic process&apos; SubClassOf &apos;xenobiotic catabolic process&apos;</newAxiom>
<newAxiom>&apos;codeine catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2001291</classIRI>
<classLabel>codeine metabolic process</classLabel>
<newAxiom>&apos;codeine metabolic process&apos; SubClassOf &apos;xenobiotic metabolic process&apos;</newAxiom>
<newAxiom>&apos;codeine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005542</classIRI>
<classLabel>folic acid binding</classLabel>
<newAxiom>&apos;folic acid binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902599</classIRI>
<classLabel>sulfathiazole transmembrane transport</classLabel>
<deletedAxiom>&apos;sulfathiazole transmembrane transport&apos; SubClassOf &apos;transmembrane transport&apos;</deletedAxiom>
<newAxiom>&apos;sulfathiazole transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902598</classIRI>
<classLabel>creatine transmembrane transport</classLabel>
<newAxiom>&apos;creatine transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_2001227</classIRI>
<classLabel>quercitrin binding</classLabel>
<newAxiom>&apos;quercitrin binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042542</classIRI>
<classLabel>response to hydrogen peroxide</classLabel>
<newAxiom>&apos;response to hydrogen peroxide&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
<newAxiom>&apos;response to hydrogen peroxide&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0030573</classIRI>
<classLabel>bile acid catabolic process</classLabel>
<deletedAxiom>&apos;bile acid catabolic process&apos; SubClassOf &apos;organic hydroxy compound catabolic process&apos;</deletedAxiom>
<deletedAxiom>&apos;bile acid catabolic process&apos; SubClassOf &apos;steroid catabolic process&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902708</classIRI>
<classLabel>response to plumbagin</classLabel>
<newAxiom>&apos;response to plumbagin&apos; SubClassOf &apos;response to antineoplastic agent&apos;</newAxiom>
<newAxiom>&apos;response to plumbagin&apos; SubClassOf &apos;response to anticoagulant&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902709</classIRI>
<classLabel>cellular response to plumbagin</classLabel>
<newAxiom>&apos;cellular response to plumbagin&apos; SubClassOf &apos;cellular response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902712</classIRI>
<classLabel>G-protein coupled GABA receptor complex</classLabel>
<newAxiom>&apos;G-protein coupled GABA receptor complex&apos; SubClassOf &apos;neurotransmitter receptor complex&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902788</classIRI>
<classLabel>response to isooctane</classLabel>
<newAxiom>&apos;response to isooctane&apos; SubClassOf &apos;response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902789</classIRI>
<classLabel>cellular response to isooctane</classLabel>
<newAxiom>&apos;cellular response to isooctane&apos; SubClassOf &apos;cellular response to toxic substance&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005524</classIRI>
<classLabel>ATP binding</classLabel>
<newAxiom>&apos;ATP binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902777</classIRI>
<classLabel>6-sulfoquinovose(1-) catabolic process</classLabel>
<newAxiom>&apos;6-sulfoquinovose(1-) catabolic process&apos; SubClassOf &apos;organic acid catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902776</classIRI>
<classLabel>6-sulfoquinovose(1-) metabolic process</classLabel>
<newAxiom>&apos;6-sulfoquinovose(1-) metabolic process&apos; SubClassOf &apos;organic acid metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0030419</classIRI>
<classLabel>nicotianamine catabolic process</classLabel>
<newAxiom>&apos;nicotianamine catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0030417</classIRI>
<classLabel>nicotianamine metabolic process</classLabel>
<newAxiom>&apos;nicotianamine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042420</classIRI>
<classLabel>dopamine catabolic process</classLabel>
<newAxiom>&apos;dopamine catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042417</classIRI>
<classLabel>dopamine metabolic process</classLabel>
<newAxiom>&apos;dopamine metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900065</classIRI>
<classLabel>regulation of ethanol catabolic process</classLabel>
<deletedAxiom>&apos;regulation of ethanol catabolic process&apos; SubClassOf &apos;regulation of catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;regulation of ethanol catabolic process&apos; SubClassOf &apos;regulation of cellular catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900066</classIRI>
<classLabel>positive regulation of ethanol catabolic process</classLabel>
<deletedAxiom>&apos;positive regulation of ethanol catabolic process&apos; SubClassOf &apos;positive regulation of catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;positive regulation of ethanol catabolic process&apos; SubClassOf &apos;positive regulation of cellular catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042412</classIRI>
<classLabel>taurine biosynthetic process</classLabel>
<newAxiom>&apos;taurine biosynthetic process&apos; SubClassOf &apos;organic acid biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042442</classIRI>
<classLabel>melatonin catabolic process</classLabel>
<newAxiom>&apos;melatonin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042429</classIRI>
<classLabel>serotonin catabolic process</classLabel>
<newAxiom>&apos;serotonin catabolic process&apos; SubClassOf &apos;neurotransmitter catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042428</classIRI>
<classLabel>serotonin metabolic process</classLabel>
<newAxiom>&apos;serotonin metabolic process&apos; SubClassOf &apos;neurotransmitter metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042427</classIRI>
<classLabel>serotonin biosynthetic process</classLabel>
<newAxiom>&apos;serotonin biosynthetic process&apos; SubClassOf &apos;neurotransmitter biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042426</classIRI>
<classLabel>choline catabolic process</classLabel>
<newAxiom>&apos;choline catabolic process&apos; SubClassOf &apos;neurotransmitter catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042425</classIRI>
<classLabel>choline biosynthetic process</classLabel>
<newAxiom>&apos;choline biosynthetic process&apos; SubClassOf &apos;neurotransmitter biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042457</classIRI>
<classLabel>ethylene catabolic process</classLabel>
<newAxiom>&apos;ethylene catabolic process&apos; SubClassOf &apos;hormone catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042448</classIRI>
<classLabel>progesterone metabolic process</classLabel>
<newAxiom>&apos;progesterone metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005302</classIRI>
<classLabel>L-tyrosine transmembrane transporter activity</classLabel>
<newAxiom>&apos;L-tyrosine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005304</classIRI>
<classLabel>L-valine transmembrane transporter activity</classLabel>
<newAxiom>&apos;L-valine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005307</classIRI>
<classLabel>choline:sodium symporter activity</classLabel>
<deletedAxiom>&apos;choline:sodium symporter activity&apos; SubClassOf &apos;solute:sodium symporter activity&apos;</deletedAxiom>
<newAxiom>&apos;choline:sodium symporter activity&apos; SubClassOf &apos;neurotransmitter:sodium symporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005308</classIRI>
<classLabel>creatine transmembrane transporter activity</classLabel>
<newAxiom>&apos;creatine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005313</classIRI>
<classLabel>L-glutamate transmembrane transporter activity</classLabel>
<newAxiom>&apos;L-glutamate transmembrane transporter activity&apos; SubClassOf &apos;neurotransmitter transporter activity&apos;</newAxiom>
<newAxiom>&apos;L-glutamate transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005329</classIRI>
<classLabel>dopamine transmembrane transporter activity</classLabel>
<newAxiom>&apos;dopamine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005332</classIRI>
<classLabel>gamma-aminobutyric acid:sodium symporter activity</classLabel>
<newAxiom>&apos;gamma-aminobutyric acid:sodium symporter activity&apos; SubClassOf &apos;neurotransmitter:sodium symporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005347</classIRI>
<classLabel>ATP transmembrane transporter activity</classLabel>
<newAxiom>&apos;ATP transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005368</classIRI>
<classLabel>taurine transmembrane transporter activity</classLabel>
<newAxiom>&apos;taurine transmembrane transporter activity&apos; SubClassOf &apos;organic acid transmembrane transporter activity&apos;</newAxiom>
<newAxiom>&apos;taurine transmembrane transporter activity&apos; SubClassOf &apos;xenobiotic transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042318</classIRI>
<classLabel>penicillin biosynthetic process</classLabel>
<deletedAxiom>&apos;penicillin biosynthetic process&apos; SubClassOf &apos;secondary metabolite biosynthetic process&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042317</classIRI>
<classLabel>penicillin catabolic process</classLabel>
<deletedAxiom>&apos;penicillin catabolic process&apos; SubClassOf &apos;secondary metabolite catabolic process&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042316</classIRI>
<classLabel>penicillin metabolic process</classLabel>
<deletedAxiom>&apos;penicillin metabolic process&apos; SubClassOf &apos;secondary metabolic process&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042366</classIRI>
<classLabel>cobalamin catabolic process</classLabel>
<newAxiom>&apos;cobalamin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
<newAxiom>&apos;cobalamin catabolic process&apos; SubClassOf &apos;cofactor catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042376</classIRI>
<classLabel>phylloquinone catabolic process</classLabel>
<newAxiom>&apos;phylloquinone catabolic process&apos; SubClassOf &apos;vitamin catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042374</classIRI>
<classLabel>phylloquinone metabolic process</classLabel>
<newAxiom>&apos;phylloquinone metabolic process&apos; SubClassOf &apos;vitamin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042372</classIRI>
<classLabel>phylloquinone biosynthetic process</classLabel>
<newAxiom>&apos;phylloquinone biosynthetic process&apos; SubClassOf &apos;vitamin biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042367</classIRI>
<classLabel>biotin catabolic process</classLabel>
<newAxiom>&apos;biotin catabolic process&apos; SubClassOf &apos;coenzyme catabolic process&apos;</newAxiom>
<newAxiom>&apos;biotin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902951</classIRI>
<classLabel>negative regulation of dendritic spine maintenance</classLabel>
<newAxiom>&apos;negative regulation of dendritic spine maintenance&apos; SubClassOf &apos;negative regulation of synapse organization&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1902950</classIRI>
<classLabel>regulation of dendritic spine maintenance</classLabel>
<newAxiom>&apos;regulation of dendritic spine maintenance&apos; SubClassOf http://purl.obolibrary.org/obo/GO_0099175</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900333</classIRI>
<classLabel>regulation of methane biosynthetic process from 3-(methylthio)propionic acid</classLabel>
<newAxiom>&apos;regulation of methane biosynthetic process from 3-(methylthio)propionic acid&apos; SubClassOf &apos;regulation of secondary metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900336</classIRI>
<classLabel>regulation of methane biosynthetic process from carbon monoxide</classLabel>
<newAxiom>&apos;regulation of methane biosynthetic process from carbon monoxide&apos; SubClassOf &apos;regulation of neurotransmitter levels&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019825</classIRI>
<classLabel>oxygen binding</classLabel>
<deletedAxiom>&apos;oxygen binding&apos; SubClassOf &apos;binding&apos;</deletedAxiom>
<newAxiom>&apos;oxygen binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019852</classIRI>
<classLabel>L-ascorbic acid metabolic process</classLabel>
<newAxiom>&apos;L-ascorbic acid metabolic process&apos; SubClassOf &apos;coenzyme metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019853</classIRI>
<classLabel>L-ascorbic acid biosynthetic process</classLabel>
<newAxiom>&apos;L-ascorbic acid biosynthetic process&apos; SubClassOf &apos;coenzyme biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019854</classIRI>
<classLabel>L-ascorbic acid catabolic process</classLabel>
<newAxiom>&apos;L-ascorbic acid catabolic process&apos; SubClassOf &apos;coenzyme catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019860</classIRI>
<classLabel>uracil metabolic process</classLabel>
<newAxiom>&apos;uracil metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032841</classIRI>
<classLabel>calcitonin binding</classLabel>
<newAxiom>&apos;calcitonin binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042201</classIRI>
<classLabel>N-cyclopropylmelamine metabolic process</classLabel>
<newAxiom>&apos;N-cyclopropylmelamine metabolic process&apos; SubClassOf &apos;insecticide metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032882</classIRI>
<classLabel>regulation of chitin metabolic process</classLabel>
<newAxiom>&apos;regulation of chitin metabolic process&apos; SubClassOf &apos;regulation of cellular metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0030209</classIRI>
<classLabel>dermatan sulfate catabolic process</classLabel>
<newAxiom>&apos;dermatan sulfate catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0030205</classIRI>
<classLabel>dermatan sulfate metabolic process</classLabel>
<newAxiom>&apos;dermatan sulfate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005277</classIRI>
<classLabel>acetylcholine transmembrane transporter activity</classLabel>
<newAxiom>&apos;acetylcholine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005278</classIRI>
<classLabel>acetylcholine:proton antiporter activity</classLabel>
<deletedAxiom>&apos;acetylcholine:proton antiporter activity&apos; SubClassOf &apos;solute:proton antiporter activity&apos;</deletedAxiom>
<newAxiom>&apos;acetylcholine:proton antiporter activity&apos; SubClassOf &apos;drug:proton antiporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042220</classIRI>
<classLabel>response to cocaine</classLabel>
<newAxiom>&apos;response to cocaine&apos; SubClassOf &apos;response to xenobiotic stimulus&apos;</newAxiom>
<newAxiom>&apos;response to cocaine&apos; SubClassOf &apos;response to anesthetic&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042216</classIRI>
<classLabel>phenanthrene catabolic process</classLabel>
<newAxiom>&apos;phenanthrene catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0005290</classIRI>
<classLabel>L-histidine transmembrane transporter activity</classLabel>
<newAxiom>&apos;L-histidine transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042203</classIRI>
<classLabel>toluene catabolic process</classLabel>
<newAxiom>&apos;toluene catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042202</classIRI>
<classLabel>N-cyclopropylmelamine catabolic process</classLabel>
<newAxiom>&apos;N-cyclopropylmelamine catabolic process&apos; SubClassOf &apos;insecticide catabolic process&apos;</newAxiom>
<newAxiom>&apos;N-cyclopropylmelamine catabolic process&apos; SubClassOf &apos;detoxification of nitrogen compound&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042166</classIRI>
<classLabel>acetylcholine binding</classLabel>
<newAxiom>&apos;acetylcholine binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
<newAxiom>&apos;acetylcholine binding&apos; SubClassOf &apos;hormone binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0030184</classIRI>
<classLabel>nitric oxide transmembrane transporter activity</classLabel>
<newAxiom>&apos;nitric oxide transmembrane transporter activity&apos; SubClassOf &apos;neurotransmitter transporter activity&apos;</newAxiom>
<newAxiom>&apos;nitric oxide transmembrane transporter activity&apos; SubClassOf &apos;drug transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0030185</classIRI>
<classLabel>nitric oxide transport</classLabel>
<newAxiom>&apos;nitric oxide transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
<newAxiom>&apos;nitric oxide transport&apos; SubClassOf &apos;neurotransmitter transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0030186</classIRI>
<classLabel>melatonin metabolic process</classLabel>
<newAxiom>&apos;melatonin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0030170</classIRI>
<classLabel>pyridoxal phosphate binding</classLabel>
<deletedAxiom>&apos;pyridoxal phosphate binding&apos; SubClassOf &apos;cofactor binding&apos;</deletedAxiom>
<newAxiom>&apos;pyridoxal phosphate binding&apos; SubClassOf &apos;coenzyme binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042188</classIRI>
<classLabel>1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolic process</classLabel>
<newAxiom>&apos;1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042183</classIRI>
<classLabel>formate catabolic process</classLabel>
<newAxiom>&apos;formate catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042190</classIRI>
<classLabel>vanillin catabolic process</classLabel>
<newAxiom>&apos;vanillin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0017107</classIRI>
<classLabel>anion exchanger adaptor activity</classLabel>
<deletedAxiom>&apos;anion exchanger adaptor activity&apos; SubClassOf &apos;protein binding, bridging&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032782</classIRI>
<classLabel>bile acid secretion</classLabel>
<deletedAxiom>&apos;bile acid secretion&apos; SubClassOf &apos;bile acid and bile salt transport&apos;</deletedAxiom>
<newAxiom>&apos;bile acid secretion&apos; SubClassOf &apos;monocarboxylic acid transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042122</classIRI>
<classLabel>alginic acid catabolic process</classLabel>
<newAxiom>&apos;alginic acid catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0042120</classIRI>
<classLabel>alginic acid metabolic process</classLabel>
<newAxiom>&apos;alginic acid metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0030152</classIRI>
<classLabel>bacteriocin biosynthetic process</classLabel>
<deletedAxiom>&apos;bacteriocin biosynthetic process&apos; SubClassOf &apos;toxin biosynthetic process&apos;</deletedAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900539</classIRI>
<classLabel>fumonisin metabolic process</classLabel>
<deletedAxiom>&apos;fumonisin metabolic process&apos; SubClassOf &apos;secondary metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;fumonisin metabolic process&apos; SubClassOf &apos;mycotoxin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900573</classIRI>
<classLabel>emodin metabolic process</classLabel>
<newAxiom>&apos;emodin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900574</classIRI>
<classLabel>emodin catabolic process</classLabel>
<newAxiom>&apos;emodin catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900540</classIRI>
<classLabel>fumonisin catabolic process</classLabel>
<deletedAxiom>&apos;fumonisin catabolic process&apos; SubClassOf &apos;secondary metabolite catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;fumonisin catabolic process&apos; SubClassOf &apos;mycotoxin catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900541</classIRI>
<classLabel>fumonisin biosynthetic process</classLabel>
<deletedAxiom>&apos;fumonisin biosynthetic process&apos; SubClassOf &apos;secondary metabolite biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;fumonisin biosynthetic process&apos; SubClassOf &apos;mycotoxin biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900552</classIRI>
<classLabel>asperfuranone metabolic process</classLabel>
<newAxiom>&apos;asperfuranone metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900553</classIRI>
<classLabel>asperfuranone catabolic process</classLabel>
<newAxiom>&apos;asperfuranone catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900588</classIRI>
<classLabel>violaceol I metabolic process</classLabel>
<deletedAxiom>&apos;violaceol I metabolic process&apos; SubClassOf &apos;secondary metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;violaceol I metabolic process&apos; SubClassOf &apos;mycotoxin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900589</classIRI>
<classLabel>violaceol I catabolic process</classLabel>
<deletedAxiom>&apos;violaceol I catabolic process&apos; SubClassOf &apos;secondary metabolite catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;violaceol I catabolic process&apos; SubClassOf &apos;mycotoxin catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900590</classIRI>
<classLabel>violaceol I biosynthetic process</classLabel>
<deletedAxiom>&apos;violaceol I biosynthetic process&apos; SubClassOf &apos;secondary metabolite biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;violaceol I biosynthetic process&apos; SubClassOf &apos;mycotoxin biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900591</classIRI>
<classLabel>violaceol II metabolic process</classLabel>
<deletedAxiom>&apos;violaceol II metabolic process&apos; SubClassOf &apos;secondary metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;violaceol II metabolic process&apos; SubClassOf &apos;mycotoxin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900592</classIRI>
<classLabel>violaceol II catabolic process</classLabel>
<deletedAxiom>&apos;violaceol II catabolic process&apos; SubClassOf &apos;secondary metabolite catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;violaceol II catabolic process&apos; SubClassOf &apos;mycotoxin catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900593</classIRI>
<classLabel>violaceol II biosynthetic process</classLabel>
<deletedAxiom>&apos;violaceol II biosynthetic process&apos; SubClassOf &apos;secondary metabolite biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;violaceol II biosynthetic process&apos; SubClassOf &apos;mycotoxin biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019608</classIRI>
<classLabel>nicotine catabolic process</classLabel>
<deletedAxiom>&apos;nicotine catabolic process&apos; SubClassOf &apos;catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;nicotine catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019619</classIRI>
<classLabel>3,4-dihydroxybenzoate catabolic process</classLabel>
<newAxiom>&apos;3,4-dihydroxybenzoate catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0017001</classIRI>
<classLabel>antibiotic catabolic process</classLabel>
<deletedAxiom>&apos;antibiotic catabolic process&apos; SubClassOf &apos;cellular catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;antibiotic catabolic process&apos; SubClassOf &apos;toxin catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0017000</classIRI>
<classLabel>antibiotic biosynthetic process</classLabel>
<deletedAxiom>&apos;antibiotic biosynthetic process&apos; SubClassOf &apos;cellular biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;antibiotic biosynthetic process&apos; SubClassOf &apos;toxin biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0044610</classIRI>
<classLabel>FMN transmembrane transporter activity</classLabel>
<newAxiom>&apos;FMN transmembrane transporter activity&apos; SubClassOf &apos;coenzyme transmembrane transporter activity&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019695</classIRI>
<classLabel>choline metabolic process</classLabel>
<newAxiom>&apos;choline metabolic process&apos; SubClassOf &apos;neurotransmitter metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0044597</classIRI>
<classLabel>daunorubicin metabolic process</classLabel>
<newAxiom>&apos;daunorubicin metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0044589</classIRI>
<classLabel>pectin binding</classLabel>
<newAxiom>&apos;pectin binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019510</classIRI>
<classLabel>S-adenosylhomocysteine catabolic process</classLabel>
<newAxiom>&apos;S-adenosylhomocysteine catabolic process&apos; SubClassOf &apos;cofactor catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019517</classIRI>
<classLabel>L-threonine catabolic process to D-lactate</classLabel>
<newAxiom>&apos;L-threonine catabolic process to D-lactate&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019518</classIRI>
<classLabel>L-threonine catabolic process to glycine</classLabel>
<newAxiom>&apos;L-threonine catabolic process to glycine&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019529</classIRI>
<classLabel>taurine catabolic process</classLabel>
<newAxiom>&apos;taurine catabolic process&apos; SubClassOf &apos;organic acid catabolic process&apos;</newAxiom>
<newAxiom>&apos;taurine catabolic process&apos; SubClassOf &apos;xenobiotic catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019530</classIRI>
<classLabel>taurine metabolic process</classLabel>
<newAxiom>&apos;taurine metabolic process&apos; SubClassOf &apos;xenobiotic metabolic process&apos;</newAxiom>
<newAxiom>&apos;taurine metabolic process&apos; SubClassOf &apos;organic acid metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019537</classIRI>
<classLabel>vibriobactin biosynthetic process</classLabel>
<newAxiom>&apos;vibriobactin biosynthetic process&apos; SubClassOf &apos;cofactor biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019541</classIRI>
<classLabel>propionate metabolic process</classLabel>
<newAxiom>&apos;propionate metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019543</classIRI>
<classLabel>propionate catabolic process</classLabel>
<newAxiom>&apos;propionate catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032500</classIRI>
<classLabel>muramyl dipeptide binding</classLabel>
<newAxiom>&apos;muramyl dipeptide binding&apos; SubClassOf &apos;drug binding&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032570</classIRI>
<classLabel>response to progesterone</classLabel>
<newAxiom>&apos;response to progesterone&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032573</classIRI>
<classLabel>response to phylloquinone</classLabel>
<newAxiom>&apos;response to phylloquinone&apos; SubClassOf &apos;response to vitamin&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032495</classIRI>
<classLabel>response to muramyl dipeptide</classLabel>
<newAxiom>&apos;response to muramyl dipeptide&apos; SubClassOf &apos;response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900770</classIRI>
<classLabel>fumitremorgin B metabolic process</classLabel>
<deletedAxiom>&apos;fumitremorgin B metabolic process&apos; SubClassOf &apos;secondary metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;fumitremorgin B metabolic process&apos; SubClassOf &apos;mycotoxin metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900771</classIRI>
<classLabel>fumitremorgin B catabolic process</classLabel>
<deletedAxiom>&apos;fumitremorgin B catabolic process&apos; SubClassOf &apos;secondary metabolite catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;fumitremorgin B catabolic process&apos; SubClassOf &apos;detoxification of nitrogen compound&apos;</newAxiom>
<newAxiom>&apos;fumitremorgin B catabolic process&apos; SubClassOf &apos;mycotoxin catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900772</classIRI>
<classLabel>fumitremorgin B biosynthetic process</classLabel>
<deletedAxiom>&apos;fumitremorgin B biosynthetic process&apos; SubClassOf &apos;secondary metabolite biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;fumitremorgin B biosynthetic process&apos; SubClassOf &apos;mycotoxin biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900749</classIRI>
<classLabel>(R)-carnitine transport</classLabel>
<newAxiom>&apos;(R)-carnitine transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
<newAxiom>&apos;(R)-carnitine transport&apos; SubClassOf &apos;vitamin transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900794</classIRI>
<classLabel>terrequinone A metabolic process</classLabel>
<newAxiom>&apos;terrequinone A metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900795</classIRI>
<classLabel>terrequinone A catabolic process</classLabel>
<newAxiom>&apos;terrequinone A catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900797</classIRI>
<classLabel>cordyol C metabolic process</classLabel>
<newAxiom>&apos;cordyol C metabolic process&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900798</classIRI>
<classLabel>cordyol C catabolic process</classLabel>
<newAxiom>&apos;cordyol C catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019415</classIRI>
<classLabel>acetate biosynthetic process from carbon monoxide</classLabel>
<newAxiom>&apos;acetate biosynthetic process from carbon monoxide&apos; SubClassOf &apos;neurotransmitter metabolic process&apos;</newAxiom>
<newAxiom>&apos;acetate biosynthetic process from carbon monoxide&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019429</classIRI>
<classLabel>fluorene catabolic process</classLabel>
<newAxiom>&apos;fluorene catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019477</classIRI>
<classLabel>L-lysine catabolic process</classLabel>
<newAxiom>&apos;L-lysine catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019482</classIRI>
<classLabel>beta-alanine metabolic process</classLabel>
<newAxiom>&apos;beta-alanine metabolic process&apos; SubClassOf &apos;neurotransmitter metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019483</classIRI>
<classLabel>beta-alanine biosynthetic process</classLabel>
<newAxiom>&apos;beta-alanine biosynthetic process&apos; SubClassOf &apos;neurotransmitter biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019484</classIRI>
<classLabel>beta-alanine catabolic process</classLabel>
<newAxiom>&apos;beta-alanine catabolic process&apos; SubClassOf &apos;neurotransmitter catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019386</classIRI>
<classLabel>methanogenesis, from carbon dioxide</classLabel>
<newAxiom>&apos;methanogenesis, from carbon dioxide&apos; SubClassOf &apos;drug metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032361</classIRI>
<classLabel>pyridoxal phosphate catabolic process</classLabel>
<deletedAxiom>&apos;pyridoxal phosphate catabolic process&apos; SubClassOf &apos;cofactor catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;pyridoxal phosphate catabolic process&apos; SubClassOf &apos;coenzyme catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019382</classIRI>
<classLabel>carbon tetrachloride catabolic process</classLabel>
<deletedAxiom>&apos;carbon tetrachloride catabolic process&apos; SubClassOf &apos;chlorinated hydrocarbon catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;carbon tetrachloride catabolic process&apos; SubClassOf &apos;organic substance catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019396</classIRI>
<classLabel>gallate catabolic process</classLabel>
<newAxiom>&apos;gallate catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0032355</classIRI>
<classLabel>response to estradiol</classLabel>
<newAxiom>&apos;response to estradiol&apos; SubClassOf &apos;response to hormone&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900817</classIRI>
<classLabel>ochratoxin A catabolic process</classLabel>
<deletedAxiom>&apos;ochratoxin A catabolic process&apos; SubClassOf &apos;secondary metabolite catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;ochratoxin A catabolic process&apos; SubClassOf &apos;mycotoxin catabolic process&apos;</newAxiom>
<newAxiom>&apos;ochratoxin A catabolic process&apos; SubClassOf &apos;detoxification of nitrogen compound&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900818</classIRI>
<classLabel>ochratoxin A biosynthetic process</classLabel>
<deletedAxiom>&apos;ochratoxin A biosynthetic process&apos; SubClassOf &apos;secondary metabolite biosynthetic process&apos;</deletedAxiom>
<newAxiom>&apos;ochratoxin A biosynthetic process&apos; SubClassOf &apos;mycotoxin biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071934</classIRI>
<classLabel>thiamine transmembrane transport</classLabel>
<newAxiom>&apos;thiamine transmembrane transport&apos; SubClassOf &apos;vitamin transmembrane transport&apos;</newAxiom>
<newAxiom>&apos;thiamine transmembrane transport&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071939</classIRI>
<classLabel>vitamin A import</classLabel>
<newAxiom>&apos;vitamin A import&apos; SubClassOf &apos;drug transmembrane transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0071938</classIRI>
<classLabel>vitamin A transport</classLabel>
<newAxiom>&apos;vitamin A transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900866</classIRI>
<classLabel>glycolate transport</classLabel>
<newAxiom>&apos;glycolate transport&apos; SubClassOf &apos;drug transport&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900874</classIRI>
<classLabel>heptadec-1-ene metabolic process</classLabel>
<newAxiom>&apos;heptadec-1-ene metabolic process&apos; SubClassOf &apos;pheromone metabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900875</classIRI>
<classLabel>heptadec-1-ene biosynthetic process</classLabel>
<newAxiom>&apos;heptadec-1-ene biosynthetic process&apos; SubClassOf &apos;pheromone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010956</classIRI>
<classLabel>negative regulation of calcidiol 1-monooxygenase activity</classLabel>
<newAxiom>&apos;negative regulation of calcidiol 1-monooxygenase activity&apos; SubClassOf &apos;negative regulation of hormone biosynthetic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0010963</classIRI>
<classLabel>regulation of L-arginine import</classLabel>
<newAxiom>&apos;regulation of L-arginine import&apos; SubClassOf &apos;regulation of response to drug&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0019339</classIRI>
<classLabel>parathion catabolic process</classLabel>
<newAxiom>&apos;parathion catabolic process&apos; SubClassOf &apos;insecticide catabolic process&apos;</newAxiom>
<newAxiom>&apos;parathion catabolic process&apos; SubClassOf &apos;detoxification of nitrogen compound&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0046952</classIRI>
<classLabel>ketone body catabolic process</classLabel>
<deletedAxiom>&apos;ketone body catabolic process&apos; SubClassOf &apos;cellular catabolic process&apos;</deletedAxiom>
<newAxiom>&apos;ketone body catabolic process&apos; SubClassOf &apos;drug catabolic process&apos;</newAxiom>
</changedClass>
<changedClass>
<classIRI>http://purl.obolibrary.org/obo/GO_1900816</classIRI>
<classLabel>ochratoxin A metabolic process</classLabel>
<deletedAxiom>&apos;ochratoxin A metabolic process&apos; SubClassOf &apos;secondary metabolic process&apos;</deletedAxiom>
<newAxiom>&apos;ochratoxin A metabolic process&apos; SubClassOf &apos;mycotoxin metabolic process&apos;</newAxiom>
</changedClass>
</changedClasses>
<newClasses>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0099163</classIRI>
<classLabel>synaptic signaling by nitric oxide</classLabel>
<newAxiom>'synaptic signaling by nitric oxide' SubClassOf 'synaptic signaling'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0099173</classIRI>
<classLabel>postsynapse organization</classLabel>
<newAxiom>'postsynapse organization' SubClassOf 'cellular component organization'</newAxiom>
<newAxiom>'postsynapse organization' SubClassOf http://purl.obolibrary.org/obo/BFO_0000050 some 'synapse organization'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0099172</classIRI>
<classLabel>presynapse organization</classLabel>
<newAxiom>'presynapse organization' SubClassOf 'cellular component organization'</newAxiom>
<newAxiom>'presynapse organization' SubClassOf http://purl.obolibrary.org/obo/BFO_0000050 some 'synapse organization'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0099175</classIRI>
<classLabel>regulation of postsynapse organization</classLabel>
<newAxiom>'regulation of postsynapse organization' SubClassOf http://purl.obolibrary.org/obo/RO_0002211 some 'postsynapse organization'</newAxiom>
<newAxiom>'regulation of postsynapse organization' SubClassOf 'regulation of synapse organization'</newAxiom>
<newAxiom>'regulation of postsynapse organization' EquivalentTo 'biological_process' and (http://purl.obolibrary.org/obo/RO_0002211 some 'postsynapse organization')</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0099174</classIRI>
<classLabel>regulation of presynapse organization</classLabel>
<newAxiom>'regulation of presynapse organization' SubClassOf 'regulation of synapse organization'</newAxiom>
<newAxiom>'regulation of presynapse organization' EquivalentTo 'biological_process' and (http://purl.obolibrary.org/obo/RO_0002211 some 'presynapse organization')</newAxiom>
<newAxiom>'regulation of presynapse organization' SubClassOf http://purl.obolibrary.org/obo/RO_0002211 some 'presynapse organization'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0099177</classIRI>
<classLabel>regulation of trans-synaptic signaling</classLabel>
<newAxiom>'regulation of trans-synaptic signaling' SubClassOf http://purl.obolibrary.org/obo/RO_0002211 some 'trans-synaptic signaling'</newAxiom>
<newAxiom>'regulation of trans-synaptic signaling' SubClassOf 'regulation of signaling'</newAxiom>
<newAxiom>'regulation of trans-synaptic signaling' EquivalentTo 'biological_process' and (http://purl.obolibrary.org/obo/RO_0002211 some 'trans-synaptic signaling')</newAxiom>
<newAxiom>'regulation of trans-synaptic signaling' SubClassOf 'regulation of cell communication'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0099176</classIRI>
<classLabel>regulation of retrograde trans-synaptic signaling by trans-synaptic protein complex</classLabel>
<newAxiom>'regulation of retrograde trans-synaptic signaling by trans-synaptic protein complex' EquivalentTo 'biological_process' and (http://purl.obolibrary.org/obo/RO_0002211 some 'retrograde trans-synaptic signaling by trans-synaptic protein complex')</newAxiom>
<newAxiom>'regulation of retrograde trans-synaptic signaling by trans-synaptic protein complex' SubClassOf 'regulation of trans-synaptic signaling'</newAxiom>
<newAxiom>'regulation of retrograde trans-synaptic signaling by trans-synaptic protein complex' SubClassOf http://purl.obolibrary.org/obo/RO_0002211 some 'retrograde trans-synaptic signaling by trans-synaptic protein complex'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0099179</classIRI>
<classLabel>regulation of synaptic membrane adhesion</classLabel>
<newAxiom>'regulation of synaptic membrane adhesion' SubClassOf http://purl.obolibrary.org/obo/RO_0002211 some 'synaptic membrane adhesion'</newAxiom>
<newAxiom>'regulation of synaptic membrane adhesion' EquivalentTo 'biological_process' and (http://purl.obolibrary.org/obo/RO_0002211 some 'synaptic membrane adhesion')</newAxiom>
<newAxiom>'regulation of synaptic membrane adhesion' SubClassOf 'regulation of synapse organization'</newAxiom>
<newAxiom>'regulation of synaptic membrane adhesion' SubClassOf 'regulation of cell-cell adhesion'</newAxiom>
</newClass>
<newClass>
<classIRI>http://purl.obolibrary.org/obo/GO_0099178</classIRI>
<classLabel>regulation of retrograde trans-synaptic signaling by endocanabinoid</classLabel>
<newAxiom>'regulation of retrograde trans-synaptic signaling by endocanabinoid' SubClassOf http://purl.obolibrary.org/obo/RO_0002211 some 'retrograde trans-synaptic signaling by endocannabinoid'</newAxiom>
<newAxiom>'regulation of retrograde trans-synaptic signaling by endocanabinoid' EquivalentTo 'biological_process' and (http://purl.obolibrary.org/obo/RO_0002211 some 'retrograde trans-synaptic signaling by endocannabinoid')</newAxiom>
<newAxiom>'regulation of retrograde trans-synaptic signaling by endocanabinoid' SubClassOf 'regulation of trans-synaptic signaling'</newAxiom>
</newClass>
</newClasses>
<deletedClasses>
</deletedClasses>
</diffReport>