blood transfusion
type: Class
type: QualityValue
subclass of: SIO_001024
notation: 380

FEF 25-75 Percent Predicted Value
type: Class
type: QualityVariable
subclass of: Forced Expiratory Flow at 25-75 Percent
subclass of: Restriction
  on property: hasUnit
  has value: percent
definition: The percent ratio of a patient's best FEF 25-75 value divided by the expected or predicted FEF 25-75 value for the patient based on their demographics (typically age, height, sex, and race) and comparison with a population control group.

Lab confirmed result
type: Class
subclass of: SIO_001167

2, 2', 3, 4, 4'-Pentabromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
notation: BDE85
editorial note: To Do: align with CHEBI.

Vineland Motor Skills Domain
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment

N-ace-S-(phenl-2-hydxyetl)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCPHE
editorial note: To Do: align with CHEBI.

Uncle
type: Class
type: QualityValue
subclass of: Relative
notation: 192
definition: The brother of your father or mother or the husband of your aunt.

Daily exposure to second hand smoke
type: Class
type: QualityValue
subclass of: Frequently exposed to second hand smoke
notation: 250

environmental tobacco smoke exposure frequency
type: Class
type: NodeShape
subclass of: environmental tobacco smoke exposure measurement
subclass of: SIO_001367
comment: The frequency at which a subject is exposed to second hand tobacco smoke; measured in days per week, hours per day, etc.

Raw Score
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment
subclass of: Score

Duration of Steroid Treatment
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Prescription Medication and Dietary Supplements
subclass of: Duration of Medical Intervention
subclass of: Restriction
  some values from: Uses Steroid Treatment
  on property: SIO_000215
comment: The length of time a patient is receiving steroids as a medical treatment

unit per liter
type: SIO_000074
notation: U/l

1-hydroxyphenanthrene
type: Class
subclass of: PAH
notation: PHEN1

siemens
type: SIO_000074
notation: 1/AV

Endotoxin
type: Class
subclass of: Thing

N-Acetyl-S- (2-hydroxyethyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: HEMA2

cardiovascular system disease
type: Class
subclass of: Comorbidity Disease

noninvasive positve-pressure ventilation
type: Class
subclass of: Medical History
subclass of: artificial respiration

2, 2', 4'-Tribromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
notation: BDE17
editorial note: To Do: align with CHEBI.

Grandfather
type: Class
subclass of: Ancestor
definition: The father of your father or mother.

Duration of Chest Tube Placement
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Medical History
subclass of: Duration of Medical Procedure
subclass of: Restriction
  some values from: Chest Tube Placement
  on property: SIO_000215
comment: The length of time a patient has a chest tube placed in their chest cavity as a medical procedure

N-acel-S-(1, 2-dichlorovinl)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOC1DC
editorial note: To Do: align with CHEBI.

Study Location
type: Class
type: NodeShape
subclass of: Location
subclass of: Restriction
  some values from: Study
  on property: SIO_000145
comment: The location where a clinical study is conducted; this could be a hospital, medical school, university, or other research institution.

Vineland Communication Domain
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment

Several times a week exposure to second hand smoke
type: Class
type: QualityValue
subclass of: Frequently exposed to second hand smoke
notation: 251

Functional Status Score
type: Class
subclass of: Score
comment: Functional Status Score (FSS) includes six domains with a scale from 1-5 with one being normal and 5 being very severely dysfunctional. A change would represent a new morbidity for the patient after ICU admission.1 (normal) to 6 (severely dysfunctional). FSS Score Reference: Pollack, M et al. The functional status score (FSS): a new pediatric outcome measure. Pediatrics, 2009. 124(1):18-28.

unit per milliliter
type: SIO_000074
notation: U/ml

o-Xylene
type: Class
subclass of: Volatile Organic Compound
notation: OXY
definition: O-xylene is a colorless watery liquid with a sweet odor. Less dense than water. Insoluble in water. Irritating vapor. (USCG, 1999)

Cell

mono-n-butylphthalate (BzBP, DnBP)
type: Class
subclass of: Phthalate
notation: MnBP

trans, trans -Muconic acid
type: Class
subclass of: Volatile Organic Compound
notation: MU
editorial note: To Do: align with CHEBI.

2, 2', 3, 3', 4, 4', 5, 5', 6, 6'-Decabromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
notation: BDE209
editorial note: To Do: align with CHEBI.

Lipemic
type: Class
subclass of: SIO_001167

Neurological Issues from Infectious Causes of Airway Obstruction
type: Class
type: QualityValue
type: NodeShape
subclass of: Neurologic
comment: Infectious conditions that cause airway obstruction, e.g. Croup
notation: 412

Interferon gamma
type: Class
subclass of: Protein
notation: IFNG

N-ac-S-(2-carbmo-2-hydxel)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCGAM
editorial note: To Do: align with CHEBI.

Grandmother
type: Class
type: QualityValue
subclass of: Ancestor
notation: 190
definition: The mother of your father or mother.

FVC Percent Predicted Value
type: Class
type: QualityVariable
subclass of: CMO_0000251
subclass of: Restriction
  on property: hasUnit
  has value: percent
definition: The percent ratio of a patient's best FVC value divided by the expected or predicted FVC value for the patient based on their demographics (typically age, height, sex, and race) and comparison with a population control group.

Tobacco Related Exposure
type: Class
subclass of: Thing

Duration of Invasive Mechanical Ventilation
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Medical History
subclass of: Duration of Medical Intervention
subclass of: Restriction
  some values from: invasive mechanical ventilation
  on property: SIO_000215

Vineland Daily Living Skills Domain
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment

electronvolt
type: SIO_000074
notation: eV

curie
type: SIO_000074
notation: Ci

Language
type: Class
type: QualityVariable
subclass of: Acculturation
editorial note: Needs to be rooted in sio

invasive mechanical ventilation
type: Class
subclass of: Medical History
subclass of: artificial respiration

Heptyl paraben
type: Class
subclass of: Paraben
notation: HePB

2, 2', 3, 4, 4', 5', 6-Heptabromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
notation: BDE183
editorial note: To Do: align with CHEBI.

Laboratory Result
type: Class
subclass of: Indicator
definition: A measurement taken on a sample.

Aunt
type: Class
type: QualityValue
subclass of: Relative
notation: 191
definition: The sister of your father or mother or the wife of your uncle.

Neurological Issues from Non-infectious Causes of Airway Obstruction
type: Class
type: QualityValue
type: NodeShape
subclass of: Neurologic
comment: Non-infectious (mostly congenital or cancer) causes for airway obstruction
notation: 413

Vineland Socialization Domain
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment

FEV1 Percent Predicted Value
type: Class
type: QualityVariable
subclass of: CMO_0000254
subclass of: Restriction
  on property: hasUnit
  has value: percent
definition: The percent ratio of a patient's best FEV1 value divided by the expected or predicted FEV1 value for the patient based on their demographics (typically age, height, sex, and race) and comparison with a population control group.

N-ace-S-(phenl-2-hydxyetl)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCMB3
editorial note: To Do: align with CHEBI.

Monocyclohexyl phthalate
type: Class
subclass of: Phthalate
notation: MCHP

FEF 25-75 Predicted Value
type: Class
type: QualityVariable
subclass of: Forced Expiratory Flow at 25-75 Percent
subclass of: Restriction
  on property: hasUnit
  has value: liter
definition: The expected or predicted FEF 25-75 value for a patient based on their demographics (typically age, height, sex, and race) and comparison with a population control group.

Duration of Ventilator Free Respiration
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Medical History
subclass of: PATO_0001309
subclass of: Restriction
  some values from: Ventilator Free Respiration
  on property: SIO_000215
comment: The length of time a patient is able to breathe without aid of mechanical ventilation.

Strontium
type: Class
subclass of: Metal
notation: Sr
definition: STRONTIUM is an element of the alkaline earth family of metals. It has the atomic symbol Sr, atomic number 38, and atomic weight 87.62.

Perfluorooctanoic acid
type: Class
subclass of: PFC
notation: PFOA

becquerel
type: SIO_000074
notation: Bq

watt per meter kelvin
type: SIO_000074
notation: W/mK

Some College
type: Class
type: QualityValue
subclass of: Some College or Technical School
notation: 85
definition: Indicates that a person has attended college but that they did not receive any degree.
was approved by: PER-Jeanette-Stingone

High-Performance Liquid Chromatography
type: Class
subclass of: Liquid Chromatography Instrument
definition: High-performance liquid chromatography (HPLC; formerly referred to as high-pressure liquid chromatography), is a technique in analytical chemistry used to separate, identify, and quantify each component in a mixture. It relies on pumps to pass a pressurized liquid solvent containing the sample mixture through a column filled with a solid adsorbent material. Each component in the sample interacts slightly differently with the adsorbent material, causing different flow rates for the different components and leading to the separation of the components as they flow out the column.
was approved by: PER-Jim-McCusker

monoisononyl phthalate
type: Class
subclass of: Phthalate
notation: MIP
editorial note: Duplicate of mINP?

First Void Urination
type: Class
type: QualityValue
subclass of: Urination
notation: 356

Spirometry Outcomes Did Not Meet Guidelines
type: Class
type: QualityValue
subclass of: Spirometry Outcome
subclass of: Restriction
  some values from: SIO_001310
  on property: SIO_000217
notation: 281

Washing Machine Count
type: Class
type: QuantityVariable
subclass of: Household Appliance Count
definition: Number of machines used for washing clothes in the home.
was approved by: PER-Jeanette-Stingone

Mullens Verbal Domain
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment
subclass of: Restriction
  some values from: CAO_03174
  on property: wasDerivedFrom
subclass of: Restriction
  some values from: CAO_03173
  on property: wasDerivedFrom
definition: A composite score derived from the Mullens Receptive Language and Mullens Expressive Language scales.

Daily Smoker
type: Class
type: QualityValue
subclass of: Smoking Status
notation: 157

Neurological Issues with Spinal Cord
type: Class
type: QualityValue
type: NodeShape
subclass of: Neurologic
comment: These would include spinal cord and spine injuries our conditions.
notation: 409

volt per meter
type: SIO_000074
notation: V/m

abnormal cell
type: Class
subclass of: Cell

Interleukin-6
type: Class
subclass of: Protein
notation: IL6
definition: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.

chronic kidney disease
type: Class
subclass of: Comorbidity Disease

Sputum
type: Class
subclass of: Bodily Fluid
definition: Matter ejected from the lungs, bronchi, and trachea, through the mouth. [database_cross_reference: Dorlands_Medical_Dictionary:MerckSource]

Nitrogen Oxides
label: Nitrogen Oxide
type: Class
subclass of: Air Pollutant
subclass of: Metabolite

Has taken asthma control medications
type: Class
type: QualityValue
subclass of: Asthma Controller Use
notation: 282
disjoint with: Never takes asthma control medications

Weight for Height Z-Score
type: Class
type: QuantityVariable
subclass of: Z-Score
subclass of: SIO_001245
definition: Z-Score of the weight/height ratio at a given age.

t, t-Muconic acid(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCMUC
editorial note: To Do: align with CHEBI.

Occasional Smoker
type: Class
type: QualityValue
subclass of: Smoking Status
notation: 158

First Void Urine
type: Class
type: QualityValue
subclass of: Urine
subclass of: Restriction
  some values from: First Void Urination
  on property: SIO_000312
notation: 357

N-Acetyl-S-(trichlorovinyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: TCVMA
editorial note: To Do: align with CHEBI.

Neurological Issues with Cerebral Spinal Fluid
type: Class
type: QualityValue
type: NodeShape
subclass of: Neurologic
comment: Conditions that cause obstruction to cerebral spinal fluid flow or absorption
notation: 410

docosanoic acid
type: Class
subclass of: Fatty Acid
notation: C220
definition: A straight-chain, C22, long-chain saturated fatty acid.

Mullens Non-Verbal Domain
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment
subclass of: Restriction
  some values from: CAO_03172
  on property: wasDerivedFrom
subclass of: Restriction
  some values from: CAO_03171
  on property: wasDerivedFrom
definition: A composite score derived from the Mullens Visual Reception and Mullens Fine Motor scales..

electric field strength unit
type: SIO_000074
notation: Efs

Gray
type: SIO_000074
notation: Gy

esophageal disease
type: Class
subclass of: Disease

microgram per gram
type: SIO_000074
notation: ug/g

Saliva
type: Class
subclass of: Bodily Fluid
definition: A fluid produced in the oral cavity by salivary glands, typically used in predigestion, but also in other functions. [database_cross_reference: http://en.wikipedia.org/wiki/Saliva][database_cross_reference: GO:0046541]

3-hydroxyphenanthrene
type: Class
subclass of: PAH
notation: PHEN3

Plasma
type: Class
subclass of: Blood Component
definition: The liquid component of blood, in which erythrocytes are suspended. [database_cross_reference: http://orcid.org/0000-0002-6601-2165]

Mono-n-octyl phthalate
type: Class
subclass of: Phthalate
notation: MOP

infection
type: Class
type: QualityVariable
subclass of: Health Outcome
subclass of: SIO_000475

Floor Type
type: Class
type: QualityVariable
subclass of: Housing Characteristic
subclass of: SIO_000004
definition: Type of material that makes up the floor.
was approved by: PER-Jeanette-Stingone

mono-isodecyl phthalate
type: Class
subclass of: Phthalate
notation: mIDP

Asian Non-Hispanic
type: Class
type: QualityValue
subclass of: Non-Hispanic Ethnicity
subclass of: Asian
notation: 217

VCR Player Count
type: Class
type: QuantityVariable
subclass of: Household Appliance Count
definition: Number of devices that play VCRs in the home.
was approved by: PER-Jeanette-Stingone

millisievert
type: SIO_000074
notation: mSv

Postnatal Period
type: Class
type: NodeShape
subclass of: SIO_000417
comment: The time period after birth.

Annual Income $30,000 to $60,000
type: Class
type: QualityValue
subclass of: Household Income
notation: 349

Occasional E-Cigarette Use
type: Class
type: QualityValue
subclass of: E-Cigarette Use
notation: 155

Spirometry Outcome
type: Class
type: QualityVariable
subclass of: Physical And Mental Assessment
subclass of: Respiratory System Findings Original Result
subclass of: Restriction
  some values from: NCIT C85397
  on property: SIO_001157

kilodalton
type: SIO_000074
notation: kDa

sievert
type: SIO_000074
notation: Sv

Perfluorononanoic acid
type: Class
subclass of: PFC
notation: PFNA

Interleukin-17F
type: Class
subclass of: Protein
notation: IL17F

SIO_000980
type: QualityValue
notation: 107

Behavioral Experimental Paradigm Condition
type: Class
subclass of: Neurocognitive Assessment

Gravida
type: Class
type: QuantityVariable
subclass of: SIO_000794
subclass of: Pregnancy Characteristic
definition: Pregnancy Count, regardless of whether pregnancy was carried to Term.
was approved by: PER-Jeanette-Stingone

American Indian Non-Hispanic
type: Class
type: QualityValue
subclass of: American Indian Or Alaskan Native
subclass of: Non-Hispanic Ethnicity
notation: 218

Annual Income More Than $60,000
type: Class
type: QualityValue
subclass of: Household Income
notation: 350

mono-isopropyl phthalate
type: Class
subclass of: Phthalate
notation: mIPrP
editorial note: Duplicate of MiPP?

Vacuum Cleaner Count
type: Class
type: QuantityVariable
subclass of: Household Appliance Count
definition: Number of appliances in home used for cleaning rugs.
was approved by: PER-Jeanette-Stingone

Daily E-Cigarette Use
type: Class
type: QualityValue
subclass of: E-Cigarette Use
notation: 156

e-cigarette behavior
type: Class
type: NodeShape
subclass of: Alcohol, Tobacco, and Illicit Drug Use
subclass of: GO_0007610
comment: Inhaling and exhaling the vapors produced by electronic cigarette, or "vaping" devices.

Skin rash
type: Class
type: QualityValue
subclass of: Inflammatory abnormality of the skin
comment: A red eruption of the skin.
notation: 426

Spirometry Outcomes Met Guidelines
type: Class
type: QualityValue
subclass of: Spirometry Outcome
subclass of: Restriction
  some values from: SIO_001312
  on property: SIO_000217
notation: 280

absorbance unit
type: SIO_000074
notation: AU

roentgen
type: SIO_000074
notation: Roentgen

dalton
type: SIO_000074
notation: Da

SIO_000981
type: QualityValue
notation: 108

Abnormality of the musculoskeletal system
type: Class
type: QualityValue
subclass of: SIO_010056
notation: 386

1, 2-Dichloroethane
type: Class
subclass of: Volatile Organic Compound
notation: DE12
definition: Ethylene Dichloride is a clear, colorless, oily, synthetic, flammable liquid chlorinated hydrocarbon with a pleasant chloroform-like smell that emits toxic fumes of hydrochloric acid when heated to decomposition. Ethylene dichloride is primarily used to produce vinyl chloride. Inhalation exposure to this substance induces respiratory distress, nausea and vomiting and affects the central nervous system, liver and kidneys. It is mutagenic in animals and is reasonably anticipated to be a human carcinogen. (NCI05)

central venous cannula insertion
type: Class
subclass of: Medical History
subclass of: Activity

Rarely exposed to second hand smoke from E-cigarettes
type: Class
type: QualityValue
subclass of: environmental e-cigarette smoke exposure
notation: 258

Autism Spectrum Disorder
type: Class
type: QualityValue
subclass of: Developmental Disorder of Mental Health
notation: 151

DERP1 Dust Mite Allergen
type: Class
subclass of: Allergen

Functional Status Total Score
type: Class
subclass of: Physical And Mental Assessment
subclass of: Functional Status Score

Demographic
type: Class
subclass of: StudyIndicator
definition: Demographics are quantifiable characteristics of a given population.
was approved by: PER-Jeanette-Stingone
editorial note: SDD-2016-1431-P01_SG_Dictionary_SDD_v1.xlsx

Drug History
type: Class
type: QualityVariable
subclass of: Alcohol, Tobacco, and Illicit Drug Use
notation: 14

Has Breastfed At Least Once
type: Class
type: NodeShape
subclass of: Breast Feeding
comment: Child has breastfed at least once

Markedly hemolyzed
type: Class
subclass of: SIO_001167

Lack of spontaneous play
type: Class
subclass of: SIO_000475

Monocyte
type: Class
subclass of: Lymphocyte
definition: Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells.

kilogram per square meter
type: SIO_000074
notation: kg/m2

parts per trillion
type: SIO_000074
notation: ppt

American Indian Or Alaskan Native
type: Class
type: QualityValue
subclass of: Race
subclass of: Non-White
notation: 5
definition: A person having origins in any of the original peoples of North and South America (including Central America) and who maintains tribal affiliation or community attachment.
was approved by: PER-Jeanette-Stingone

HHEAR Ontology v1.6
root class: Thing
imports: stato.owl
imports: doid.owl
type: Ontology
imports: cmo.obo
default namespace: http://purl.org/twc/
status: UnderDevelopmentStatus
imports: core
imports: hasco
imports: vstoi
subject matter expert: bengos01
imports: pato.owl
imports: cl.owl
imports: uo.owl
imports: graphql
imports: http://dublincore.org/specifications/dublin-core/dcmi-terms/2020-01-20/
imports: prov-o
subject matter expert: stingj01
imports: COGAT
comment: The Human Health Exposure Analysis Resource (HHEAR) measures exposures that cover the breadth of the “exposome,” which encompasses all environmental exposures including chemical, physical, and biological stressors, as well as lifestyle and social environments, from conception through adulthood. Read more at: https://hhearprogram.org
imports: sio.owl
version IRI: http://purl.org/twc/HHEAR/1.6
subject area: HHEAR Ontology

Strongly Disagree
type: Class
type: NodeShape
subclass of: Disagree
comment: Intensely at odds. [Definition Source: NCI]

Has Never Breastfed
type: Class
type: NodeShape
subclass of: Feeding Method
subclass of: Class
  complement of: Has Breastfed At Least Once
comment: Has never breastfed
equivalent class: Class
  intersection of: Feeding Method
  intersection of: Class
    complement of: Has Breastfed At Least Once
  equivalent class: Has Never Breastfed

gastrointestinal system disease
type: Class
subclass of: Comorbidity Disease

Functional Status Total Score 3 or Above
type: Class
type: QualityValue
subclass of: Functional Status Total Score
notation: 368

DERF1 Dust Mite Allergen
type: Class
subclass of: Allergen

Antimalarial Use
type: Class
subclass of: SIO_001398
subclass of: Pharmacotherapy
subclass of: Restriction
  some values from: SIO_000393
  on property: SIO_000291
subclass of: Restriction
  some values from: Antimalarial
  on property: SIO_000230
definition: A subclass of medical intervention that characterizes a patient's experience with using an antimalarial. Subclasses detail the level to which a patient has used such a medication to prevent or treat malaria.

Dental Fillings
type: Class
type: QualityValue
subclass of: Oral Health
notation: 13

Liquid Chromotography-Multistage Mass Spectrometery
type: Class
subclass of: MassSpectrometry

neural cell
type: Class
subclass of: Cell

Bisphenol F
type: Class
subclass of: Environmental Phenol
notation: BPF

Computer
type: Class
type: QuantityVariable
subclass of: Household Appliance Count
definition: A machine used for computation and much more.
was approved by: PER-Jeanette-Stingone

Drinking Water
type: Class
subclass of: Environmental Material
definition: Drinking water is water which may be consumed by humans with no adverse effects on their health.
definition: Drinking Water

parts per billion
type: SIO_000074
notation: ppb

candela per square meter
type: SIO_000074
notation: cd/m2

waist height ratio
type: Class
type: NodeShape
subclass of: Anthropometry
subclass of: SIO_001018
comment: A quantification of the waist-height WHtR - a measurement of body fat distribution.

Strongly Agree
type: Class
type: NodeShape
subclass of: Agree
comment: Intense concurrence. [Definition Source: NCI]

Non-Biological Relative
type: Class
subclass of: Relative
definition: People that are considered relatives but are not related by blood. This includes relatives by marriage, adoption, or fosterage.

Fms-related tyrosine kinase 3 ligand
type: Class
subclass of: Protein
notation: FLT3L

Several times a week exposure to second hand smoke from E-cigarettes
type: Class
type: QualityValue
subclass of: environmental e-cigarette smoke exposure
notation: 256

Functional Status Feeding Score
type: Class
subclass of: Functional Status Score

Smokes 36-44 Cigarettes Per Day
type: Class
type: NodeShape
subclass of: cigarettes per day measurement
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001114
    intersection of: Restriction
      on property: SIO_000300
      has value: 44
  on property: SIO_000216
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 36
  on property: SIO_000216
subclass of: Restriction
  on property: SIO_000221
  has value: cigarettes per day
comment: The act of smoking between 36 and 44 cigarettes per day

Mouse Allergen
type: Class
subclass of: Allergen

glucose
type: Class
subclass of: Biological Response
subclass of: Metabolite
definition: An aldohexose used as a source of energy and metabolic intermediate.

Developmental Quality
type: Class
type: QualityVariable
subclass of: SIO_000475
definition: Refers to which stage of development a person is in.
was approved by: PER-Jeanette-Stingone

Gas Chromatography Instrument
type: Class
subclass of: Chromatography Instrument
definition: Gas chromatography (GC) is a common type of chromatography used in analytical chemistry for separating and analyzing compounds that can be vaporized without decomposition. Typical uses of GC include testing the purity of a particular substance, or separating the different components of a mixture (the relative amounts of such components can also be determined). In some situations, GC may help in identifying a compound. In preparative chromatography, GC can be used to prepare pure compounds from a mixture.
was approved by: PER-Jim-McCusker

Perfluorobutanoic acid
type: Class
subclass of: PFC
notation: PFBA

blood monocyte count
type: Class
subclass of: SIO_000794

gram per mole
type: SIO_000074
notation: g/mol

gram per milliliter
type: SIO_000074
notation: g/ml

Perfluoro-n-pentanoic acid
type: Class
subclass of: PFC
notation: PFPeA

millimole
type: SIO_000074
notation: mmol

nanogram per gram
type: SIO_000074
notation: ng/g

Functional Status Respiratory Status Score
type: Class
subclass of: Physical And Mental Assessment
subclass of: Functional Status Score

Several times a month exposure to second hand smoke from E-cigarettes
type: Class
type: QualityValue
subclass of: environmental e-cigarette smoke exposure
notation: 257

Bedroom Dust
type: Class
subclass of: Allergen
subclass of: dust

systemic lupus erythematosus
type: Class
subclass of: Disease

septic shock
type: Class
subclass of: SIO_010056
subclass of: Sepsis, Septic Shock, or SIRS

Smokes 45+ Cigarettes Per Day
type: Class
type: NodeShape
subclass of: cigarettes per day measurement
subclass of: Restriction
  on property: SIO_000221
  has value: cigarettes per day
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 45
  on property: SIO_000216
comment: The act of smoking 45 or more cigarettes per day

Detectable
type: Class
subclass of: SIO_001167

Fibrinogen Assay (Clauss method)
type: Class
subclass of: SIO_001007

Mass Spectrometer
type: Class
subclass of: PhysicalInstrument
definition: Mass spectrometry (MS) is an analytical technique that ionizes chemical species and sorts the ions based on their mass-to-charge ratio. In simpler terms, a mass spectrum measures the masses within a sample. Mass spectrometry is used in many different fields and is applied to pure samples as well as complex mixtures.
was approved by: PER-Jim-McCusker

kilogram per mole
type: SIO_000074
notation: kg/mol

9-hydroxyphenanthrene
type: Class
subclass of: PAH
notation: PHEN9

Blood Eosinophil Count
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment

Perfluorohexanoic acid
type: Class
subclass of: PFC
notation: PFHxA

parts per quadrillion
type: SIO_000074
notation: ppq

Uses Iron Supplement
type: Class
type: QualityValue
subclass of: nutrition intake
subclass of: Restriction
  some values from: Iron Vitamin Supplement
  on property: SIO_000139
notation: 332

No Formal Education
type: Class
type: QualityValue
subclass of: Education
notation: 57
definition: Has not been educated in a formal setting.
was approved by: PER-Jeanette-Stingone

Never exposed to second hand smoke
type: Class
type: QualityValue
subclass of: environmental tobacco smoke exposure measurement
notation: 254

Dog Allergen
type: Class
subclass of: Allergen

Lipemic sample, clarified before running
type: Class
subclass of: SIO_001167

Functional Status Communication Score
type: Class
subclass of: Functional Status Score

Does Not Use Antibiotics During Hospital Admission
type: Class
type: QualityValue
type: NodeShape
subclass of: Hospital Admission By Antibiotic Use
subclass of: Class
  complement of: Restriction
    some values from: Uses Antibiotics
    on property: SIO_000325
comment: This class indicates when a patient does not antibiotics during a hospital admission. The patient may have used antibiotics prior to hospital admission or after discharge.
notation: 442
equivalent class: Class
  intersection of: Hospital Admission
  intersection of: Class
    complement of: Restriction
      some values from: Uses Antibiotics
      on property: SIO_000325
  equivalent class: Does Not Use Antibiotics During Hospital Admission
disjoint with: Uses Antibiotics During Hospital Admission

beverage
type: Class
type: NodeShape
subclass of: beverage food product
comment: A liquid prepared for consumption

gram per liter
type: SIO_000074
notation: g/L

picomole
type: SIO_000074
notation: pmol

Occupation
type: Class
type: QualityVariable
subclass of: Demographic
subclass of: SIO_000016
subclass of: Socioeconomic Status
definition: An individual attribute that is the usual or principal work or business of an individual.
was approved by: PER-Jeanette-Stingone

birthing
type: Class
subclass of: Birth Outcome

fine respirable suspended particulate matter
type: Class
type: QualityVariable
subclass of: Air Pollutant

Perfluorooctanesulfonic acid
type: Class
subclass of: PFC
notation: PFOS
definition: Perfluoroalkyls are stable, synthetic chemicals. Perfluoroalkyls are unique because they repel oil, grease, and water. The two perfluoroalkyls made in the largest amounts in the U. S. areperflurooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS). Perfluoroalkyls have been used in surface protection products such as carpet and clothing treatments and coating for paper and cardboard packaging. They have also been used in fire-fighting foams.

No Insurance / Self-funded
type: Class
type: QualityValue
subclass of: Private Insurance or Self Pay
notation: 89

Folic Acid Vitamin Supplement
type: Class
subclass of: Vitamin
subclass of: Restriction
  some values from: CHEBI_27470
  on property: SIO_000313

Daily Exposure to Second Hand Smoke from E-cigarettes
type: Class
type: QualityValue
subclass of: environmental e-cigarette smoke exposure
notation: 255

Lipemic and turbid
type: Class
subclass of: SIO_001167

Functional Status Motor Functioning Score
type: Class
subclass of: Functional Status Score

Cat Allergen
type: Class
subclass of: Allergen

blood lymphocyte count
type: Class
subclass of: SIO_000794

3,5,6-trichloropyridine-2-one
type: Class
subclass of: Metabolite
definition: A pyridone that is pyridin-2(1H)-one substituted by chloro groups at positions 3, 5 and 6. It is a metabolite of the agrochemical chlorpyrifos.

2-hydroxynaphthalene
type: Class
subclass of: PAH
notation: NAP2

kilogram per liter
type: SIO_000074
notation: kg/L

cubic meter per mole
type: SIO_000074
notation: m3/mol

nanomole
type: SIO_000074
notation: nmol

surgical procedure
type: Class
type: QualityVariable
subclass of: SIO_001024

Disagree
type: Class
type: NodeShape
subclass of: Agreement Answer
comment: To be at odds. [Definition Source: NCI]

Feeding Method
type: Class
type: NodeShape
subclass of: nutrition intake
subclass of: Diet and Nutrition
comment: A description of the technique for the manner in which a subject is administered food. [Definition Source: NCI]

Study Hospital
type: Class
type: NodeShape
subclass of: Hospital
subclass of: Study Location
comment: The hospital at which a study is conducted

N-acetyl-S-(2-cyanoethyl)-L-cyst(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCCYM
editorial note: To Do: align with CHEBI.

Annual Income $5,000 or Less
type: Class
type: QualityValue
subclass of: Annual Income $14,999 or Less
notation: 159
definition: Personal or family annual income at or below $5,000

Several times a month exposure to second hand smoke
type: Class
type: QualityValue
subclass of: Ever exposed to second hand smoke
notation: 252

hematopoietic system disease
type: Class
subclass of: Comorbidity Disease

Competitive-inhibition enzyme-linked immunosorbent assay
type: Class
subclass of: enzyme-linked immunosorbent assay (ELISA)

Functional Status Mental Status Score
type: Class
subclass of: Functional Status Score

Uses Antibiotics During Hospital Admission
type: Class
type: QualityValue
type: NodeShape
subclass of: Hospital Admission By Antibiotic Use
subclass of: Restriction
  some values from: Uses Antibiotics
  on property: SIO_000325
comment: This class indicates when a patient is using antibiotics during a hospital admission. The use of the antibiotics may precede the hospital admission, extend beyond hospital discharge, or occur wholly within the hospital admission.
notation: 441
equivalent class: Class
  intersection of: Hospital Admission
  intersection of: Restriction
    some values from: Uses Antibiotics
    on property: SIO_000325
  equivalent class: Uses Antibiotics During Hospital Admission
disjoint with: Does Not Use Antibiotics During Hospital Admission

Has Used Cannabinoids But No Longer
type: Class
type: QualityValue
subclass of: Consumption Behavior
notation: 331

Liquid Chromotography-Mass Spectrometery
type: Class
subclass of: MassSpectrometry

Admission
type: Class
subclass of: Thing

compound eye retinal cell
type: Class
subclass of: Cell

(15Z)-tetracosenoic acid
type: Class
subclass of: Fatty Acid
notation: C241N9
definition: A tetracosenoic acid having a cis-double bond at position 15.

attomole
type: SIO_000074
notation: amol

Agree
type: Class
type: NodeShape
subclass of: Agreement Answer
comment: To concur. [Definition Source: NCI]

Nasal congestion
type: Class
type: NodeShape
subclass of: Sneezing, Runny Nose, or Congestion
comment: Reduced ability to pass air through the nasal cavity often leading to mouth breathing.

Annual Income $5,001 to $15,000
type: Class
type: QualityValue
subclass of: Household Income
notation: 160
definition: Personal or family annual income bwtween $5,001 and $15,000

health status
type: Class
subclass of: Thing

Iron Vitamin Supplement
type: Class
subclass of: Vitamin
subclass of: Restriction
  some values from: CHEBI_18248
  on property: SIO_000313

Nicotine (total)
type: Class
subclass of: Tobacco Metabolite
notation: NICT
editorial note: To Do: align with CHEBI.

hospital-acquired infection
type: Class
subclass of: infection

Common Era
type: Class
subclass of: Relative Time
definition: Common era time measurements are referenced against (in relation to) the beginning of the common era, 1 CE (or 1 AD).
equivalent class: Restriction
  on property: inRelationTo
  has value: First Year of the Common Era
  equivalent class: Common Era

Functional Status Sensory Functioning Score
type: Class
subclass of: Functional Status Score

Rarely exposed to second hand smoke
type: Class
type: QualityValue
subclass of: Ever exposed to second hand smoke
notation: 253

Hospital Admission By Antibiotic Use
type: Class
type: QualityVariable
type: NodeShape
subclass of: Prescription Medication and Dietary Supplements
subclass of: Hospital Admission
comment: A subclass of Hospital Admission; this class differentiates between when a patient uses antibiotics at any time during a hospital admission versus when they do not.

Liquid Chromotography -tandem mass spectrometry
type: Class
subclass of: MassSpectrometry

Other Gender
type: Class
type: QualityValue
subclass of: Gender
notation: 325

femtomole
type: SIO_000074
notation: fmol

milligram per milliliter
type: SIO_000074
notation: mg/ml

Birth Order
type: Class
type: QualityVariable
subclass of: Birth Outcome

Smokes 15-24 Cigarettes Per Day
type: Class
type: NodeShape
subclass of: cigarettes per day measurement
subclass of: Restriction
  on property: SIO_000221
  has value: cigarettes per day
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001114
    intersection of: Restriction
      on property: SIO_000300
      has value: 24
  on property: SIO_000216
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 15
  on property: SIO_000216
comment: The act of smoking between 15 and 24 cigarettes per day

N-Acetyl-S-(phenyl)-L-cysteine(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCPMA
editorial note: To Do: align with CHEBI.

Result repeated with diluted sample
type: Class
subclass of: SIO_001167

2-Chlorophenol
type: Class
subclass of: Environmental Phenol
notation: MCP2
definition: 2-chlorophenol is a colorless to amber liquid with an unpleasant, penetrating odor. Density 1.265 g / cm3. Sinks in water and slowly dissolves. Freezing point 7°C (46°F). Boiling point 175°C (347°F).

Boiler Count
type: Class
type: QuantityVariable
subclass of: Household Appliance Count
definition: A boiler is an object that heats up water. This attribute quantifies the number of boilers in the home.
was approved by: PER-Jeanette-Stingone

Native Hawaiian or Other Pacific Islander
type: Class
type: QualityValue
subclass of: Race
subclass of: Non-White
notation: 55
definition: A person having origins in any of the original peoples of Hawaii, Guam, Samoa, or other Pacific Islands.
was approved by: PER-Jeanette-Stingone

Education Grade 3
type: Class
type: QualityValue
subclass of: Some Elementary School
notation: 115
definition: Finished grade 3

Competitive Immunoassay
type: Class
subclass of: Immunoassay

Education Grade
type: Class
type: QualityVariable
subclass of: Education
definition: The highest grade of education achieved
was approved by: PER-Jeanette-Stingone

Colorimetric Assay
type: Class
subclass of: SIO_001007

Boron
type: Class
subclass of: Metal
notation: B
definition: A trace element with the atomic symbol B, atomic number 5, and atomic weight [10.806; 10.821]. Boron-10, an isotope of boron, is used as a neutron absorber in BORON NEUTRON CAPTURE THERAPY.

Developmental Disorder of Mental Health
type: Class
type: QualityValue
subclass of: Disease
notation: 341

Zileuton (Zyflo)
type: Class
subclass of: Asthma Controller Medication

Smokes 25-35 Cigarettes Per Day
type: Class
type: NodeShape
subclass of: cigarettes per day measurement
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001114
    intersection of: Restriction
      on property: SIO_000300
      has value: 35
  on property: SIO_000216
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 25
  on property: SIO_000216
subclass of: Restriction
  on property: SIO_000221
  has value: cigarettes per day
comment: The act of smoking between 25 and 35 cigarettes per day

PCB28
type: Class
subclass of: Polychlorobiphenyl
notation: PCB28

Female Gender
type: Class
type: QualityValue
subclass of: Gender
notation: 324

Result repeated and confirmed
type: Class
subclass of: SIO_001167

N-Acetyl-S-(trichlorovinyl)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCTCV
editorial note: To Do: align with CHEBI.

Buccal Cell
type: Class
subclass of: Cell
definition: Cells collected from the inner epithelium of the cheek

Bottle Feeding
type: Class
type: NodeShape
subclass of: Feeding Method
comment: Provision of liquid nutrition via a closed container system with a rubber like mouthpiece resembling a nipple. [Definition Source: NCI]

Color Object Association Test
type: Class
subclass of: Neurocognitive Assessment
definition: a reliable and a valid measure of declarative memory for healthy children ages 18-36 months, living in a disadvantaged community

Cold Vapor Atomic Fluorescence Spectroscopy Instrument
type: Class
subclass of: Atomic Fluorescence Spectroscopy Instrument
definition: Used in the measurement of trace amounts of volatile heavy metals such as mercury, cold vapour AFS makes use of the unique characteristic of mercury that allows vapour measurement at room temperature.
was approved by: PER-Jim-McCusker

Education Grade 5
type: Class
type: QualityValue
subclass of: Some Middle School
notation: 117
definition: Finished grade 5

Elective Caesarian Section
type: Class
type: QualityValue
subclass of: Caesarian Section
notation: 19
definition: A caesarian section that was chosen by the mother but was not medically necessary.

Interleukin-2
type: Class
subclass of: Protein
notation: IL2

Smokes 1-4 Cigarettes Per Day
type: Class
type: NodeShape
subclass of: cigarettes per day measurement
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 1
  on property: SIO_000216
subclass of: Restriction
  on property: SIO_000221
  has value: cigarettes per day
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001114
    intersection of: Restriction
      on property: SIO_000300
      has value: 4
  on property: SIO_000216
comment: The act of smoking between 1 and 4 cigarettes per day

Alternaria Allergen
type: Class
subclass of: Allergen
subclass of: Alternaria

Assessment
type: Class
type: NodeShape
subclass of: AnalyticalMethod
comment: A measurement, evaluation, or judgment for a study variable pertaining to the status of a subject.

Master's Degree
type: Class
type: QualityValue
subclass of: Some Postgraduate
subclass of: Higher Education
notation: 143
definition: The Master's Degree is an award that requires the successful completion of a program of study of at least the full-time equivalent of 1 but not more than two academic years of work beyond the bachelor's degree.

N-Acetyl-S-(n-propyl)-L-cysteine(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCBPM
editorial note: To Do: align with CHEBI.

Reverse-Phase Mass Spectrometry Profiling
type: Class
subclass of: MassSpectrometry

Bathroom Count
type: Class
type: QuantityVariable
subclass of: Room Count
definition: Total Number of Bathrooms in the Home
was approved by: PER-Jeanette-Stingone

Sneeze
type: Class
type: NodeShape
subclass of: Sneezing, Runny Nose, or Congestion
comment: A sudden violent, spasmodic, audible expiration of breath through the nose and mouth.

Education Grade 1
type: Class
type: QualityValue
subclass of: Some Elementary School
notation: 113
definition: Finished grade 1

Cyclomicrons present
type: Class
subclass of: SIO_001167

Mono-2-(carboxymethyl) hexyl phthalate
type: Class
subclass of: Phthalate
notation: MCMHP

square meter
type: SIO_000074
notation: m2

Montelukast (Singulair)
type: Class
subclass of: Asthma Controller Medication

Smokes 5-14 Cigarettes Per Day
type: Class
type: NodeShape
subclass of: cigarettes per day measurement
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001114
    intersection of: Restriction
      on property: SIO_000300
      has value: 14
  on property: SIO_000216
subclass of: Restriction
  on property: SIO_000221
  has value: cigarettes per day
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 5
  on property: SIO_000216
comment: The act of smoking between 5 and 14 cigarettes per day

Cockroach Allergen
type: Class
subclass of: Allergen

Hair
type: Class
subclass of: Tissue
definition: A filament, mostly protein, that grows from follicles found in the dermis[WP]. [database_cross_reference: http://en.wikipedia.org/wiki/Hair]

Interleukin-13
type: Class
subclass of: Protein
notation: IL13

Result reported based on fewer replicates than required
type: Class
subclass of: SIO_001167

N-Acetyl-S-(phenyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: PMA
editorial note: To Do: align with CHEBI.

Bedroom Count
type: Class
type: QuantityVariable
subclass of: Room Count
definition: Total Number of Bedrooms in the Home
was approved by: PER-Jeanette-Stingone

Conceiving
type: Class
subclass of: SIO_000587
comment: to become pregnant with a child.

Education Grade 2
type: Class
type: QualityValue
subclass of: Some Elementary School
notation: 114
definition: Finished grade 2

cigarettes per day measurement
type: Class
type: QuantityVariable
subclass of: SIO_000794
subclass of: Alcohol, Tobacco, and Illicit Drug Use
notation: 152

Living Quarters
type: Class
subclass of: Thing

platelet count
type: Class
subclass of: SIO_000794

ventilator supporting therapy
type: Class
type: QualityValue
subclass of: SIO_001398
comment: Medical procedures that support life systems when a patient is receiving invasive ventilation treatments.
notation: 383

Endotoxin Allergen
type: Class
subclass of: Allergen
subclass of: Endotoxin

Often Feels Stressed
type: Class
type: NodeShape
subclass of: SIO_001291
subclass of: Child Stress Assessment

Benzyl paraben
type: Class
subclass of: Paraben
notation: BzPB
definition: Benzylparaben is a Standardized Chemical Allergen. The physiologic effect of benzylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity. The chemical classification of benzylparaben is Allergens.

Collection Date of Sample
type: Class
type: QuantityVariable
subclass of: SIO_000417
definition: Collection Date of Sample
was approved by: PER-Jeanette-Stingone

Atomic Emission Spectroscopy
type: Class
subclass of: Atomic Spectroscopy

cancer
type: Class
type: QualityValue
subclass of: Comorbidity Disease
notation: 381

N-Acetyl-S-(benzyl)-L-cysteine(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCBMA
editorial note: To Do: align with CHEBI.

Apgar Score
type: Class
type: QuantityVariable
subclass of: SIO_001112
subclass of: Birth Outcome
subclass of: Restriction
  on property: SIO_000300
  all values from: Datatype
    intersection of: Datatype
      with restrictions:
        min inclusive: 0
      on datatype: integer
    intersection of: Datatype
      with restrictions:
        max inclusive: 10
      on datatype: integer
definition: A method to quickly summarize the health of newborn children. The Apgar score was invented by Virginia Apgar in 1952 when Apgar was an anesthesiologist who developed the score in order to ascertain the effects of obstetric anesthesia on babies. The Apgar scale is determined by evaluating the newborn baby on five simple criteria on a scale from zero to two, then summing up the five values thus obtained. The resulting Apgar score ranges from zero to 10. The five criteria are summarized using words chosen to form a backronym (Appearance, Pulse, Grimace, Activity, Respiration).
was approved by: PER-Jeanette-Stingone

square millimeter
type: SIO_000074
notation: mm2

sequence_variant
type: Class
type: NodeShape
subclass of: SIO_000030

Aspergillus Allergen
type: Class
subclass of: Allergen
subclass of: Aspergillus

Always Feels Stressed
type: Class
type: NodeShape
subclass of: SIO_001292
subclass of: Child Stress Assessment

Chromatography Instrument
type: Class
subclass of: PhysicalInstrument
definition: Chromatography is a laboratory technique for the separation of a mixture. The mixture is dissolved in a fluid called the mobile phase, which carries it through a structure holding another material called the stationary phase. The various constituents of the mixture travel at different speeds, causing them to separate. The separation is based on differential partitioning between the mobile and stationary phases. Subtle differences in a compound's partition coefficient result in differential retention on the stationary phase and thus affect the separation.
was approved by: PER-Jim-McCusker

Atomic Absorption Spectroscopy
type: Class
subclass of: Atomic Spectroscopy

Kaufman ABC Sequence Subscale
type: Class
subclass of: Neurocognitive Assessment
definition: Subscale of Kaufman ABC designed to measure the ability to solve problems by remembering and using an ordered series of images or ideas

N-Acetyl-S-(n-propyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: BPMA
editorial note: To Do: align with CHEBI.

Arsenic Species
type: Class
subclass of: Targeted Analyte
definition: A molecular entity with arsenic components.

Conception
type: Class
subclass of: SIO_000417
subclass of: From Conception
subclass of: Beginning
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: Conceiving
definition: When a sperm fertilizes an egg
was approved by: PER-Jeanette-Stingone

8-isoprostane
type: Class
subclass of: Biological Response
subclass of: Biomolecule

white blood cell count
type: Class
subclass of: SIO_000794

Infectious Disorder
type: Class
subclass of: Disease

square centimeter
type: SIO_000074
notation: cm2

Segmented Neutrophil Percentage
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment

FEF 25-75 Best Value
type: Class
type: QualityVariable
subclass of: Forced Expiratory Flow at 25-75 Percent
subclass of: Restriction
  on property: hasUnit
  has value: liter
definition: The best FEF 25-75 value achieved by a subject during a series of FEF 25-75 measurements.

Rarely Feels Stressed
type: Class
type: NodeShape
subclass of: SIO_001290
subclass of: Child Stress Assessment

Medical Related Hospital Admission
type: Class
type: QualityValue
subclass of: Hospital Admission By Admission Type
notation: 375

Blinded Season 4 Group
type: Class
type: QualityValue
subclass of: Seasonal Population Group
notation: 301

all-cis-5, 8, 11, 14, 17-icosapentaenoic acid
type: Class
subclass of: Fatty Acid
notation: C205N3
definition: An icosapentaenoic acid having five cis-double bonds at positions 5, 8, 11, 14 and 17.

Interleukin-12 subunit alpha
type: Class
subclass of: Protein
notation: IL12P70

Collision-Induced Dissociation (CID)
type: Class
subclass of: TandemMassSpectrometry

Biospecimen
type: Class
subclass of: SIO_010412
definition: A biological laboratory specimen held by a biorepository for research. Such a specimen would be taken by sampling so as to be representative of any other specimen taken from the source of the specimen. When biological specimens are stored, ideally they remain equivalent to freshly-collected specimens for the purposes of research.

native cell
type: Class
subclass of: Cell

N-Acetyl-S-(N-methylcarbamoyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: AMCC
editorial note: To Do: align with CHEBI.

community species diversity
type: Class
subclass of: SIO_000052

Fourth
type: Class
subclass of: Thing

gram per cubic centimeter
type: SIO_000074
notation: g/cm3

GO_0016265
deprecated: true

Nitric Oxide Ventilation
type: Class
subclass of: Restriction
  some values from: Nitric Oxide
  on property: SIO_000139
subclass of: ventilator supporting therapy
subclass of: artificial respiration
comment: The administration of nitric oxide gas via artificial ventilation mechanisms.

Nitric Oxide
type: Class
subclass of: Air Pollutant

Sometimes Feels Stressed
type: Class
type: NodeShape
subclass of: SIO_001290
subclass of: Child Stress Assessment

Allergen
type: Class
subclass of: Environmental Exposure
subclass of: Allergen
subclass of: allergen

mono ethyl hexyl phthalate
type: Class
subclass of: Phthalate
notation: MEHP
definition: PHYSICAL DESCRIPTION: Clear colorless to cloudy white viscous liquid. (NTP, 1992)

College Graduate
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: Higher Education
notation: 12
definition: The quality of having graduated from College
was approved by: PER-Jeanette-Stingone

respiration
type: Class
subclass of: Process

Before
type: Class
subclass of: Relative Time
definition: A negative index of a time measurement in relation to a reference event. A conventional time measurement can be generated from a before time measurement by duplicating the measurement, reversing the sign of the value, and removing the "Before" class.

N-Acetyl-S-(benzyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: BMA
editorial note: To Do: align with CHEBI.

Alkyl Phosphate Pesticide Metabolite
type: Class
subclass of: Targeted Analyte

kilogram per cubic meter
type: SIO_000074
notation: kg/m3

Fifth
type: Class
subclass of: Thing

red blood cell count
type: Class
subclass of: SIO_000794

Carbon Tetrachloride
type: Class
subclass of: Volatile Organic Compound
notation: CTET
definition: CARBON TETRACHLORIDE is a solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed)

Blood Segmented Neurophil Count
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment

4, 4'-DDT
type: Class
subclass of: Organochlorine Compound
notation: PPDDT

disease of metabolism
type: Class
type: QualityValue
subclass of: Comorbidity Disease
notation: 403

Mandelic acid
type: Class
subclass of: Volatile Organic Compound
notation: MA
editorial note: To Do: align with CHEBI.

Did Not Consume Alcohol
type: Class
type: QualityValue
subclass of: Alcohol Use
notation: 53

Hemoglobin Genotype AA
type: Class
type: QualityValue
subclass of: Genotype
subclass of: SCD Genotype
subclass of: Class
  some values from: SCDO_0004139
  on property: SCDO_1000222
notation: 348
disjoint with: Class
  some values from: SCDO_0000514
  on property: SCDO_1000222
  disjoint with: Hemoglobin Genotype AA
disjoint with: Class
  on property: RO_0003303
  disjoint with: Hemoglobin Genotype AA
  some valuesfrom: NCIT C131682
IAO_0000115: A genotype whereby both HBB alleles produce hemoglobin beta chains for normal adult hemoglobin. Individuals with this genotype are not carriers of the sickle cell trait.
has exact synonym: Hemoglobin Genotype AA
has exact synonym: Haemoglobin Genotype AA
has exact synonym: AA Genotype
has exact synonym: AA Hemoglobin Genotype
has exact synonym: Hemoglobin A Genotype

mono-carboxy isononyl phthalate
type: Class
subclass of: Phthalate
notation: mCINP

Asthma Induced Night Sleeplessness
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment
subclass of: Sleep disturbance
subclass of: behavioral response to pain
subclass of: Restriction
  some values from: wheezing or tightness in the chest or cough
  on property: SIO_001157

Less than High School
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: High School or Less
notation: 215

Tibia
type: Class
subclass of: SIO_010046
definition: The major preaxial endochondral bone in the posterior zeugopod.

Unknown Race
type: Class
type: QualityValue
subclass of: Race
notation: 48
definition: Unknown Race

Aluminum
type: Class
subclass of: Metal
notation: Al
definition: ALUMINUM is a metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26.98.

air
type: Class
subclass of: Thing

Selenium
type: Class
subclass of: Metal
notation: Se
definition: An element with the atomic symbol Se, atomic number 34, and atomic weight 78.96. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.

Phenanthrene tetrol
notation: PHET

Screening
type: Class
subclass of: SIO_000417
definition: The time period during which a screening process is used to determine the inclusion of a subject in a study.
was approved by: PER-Jeanette-Stingone

Sickle Cell Anemia
type: Class
type: QualityValue
subclass of: Disease
notation: 122
definition: A blood protein disease that is characterized by low number of red blood cells, repeated infections, and periodic episodes of pain, resulting from atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent, shape.

Neurodevelopmental delay
type: Class
type: NodeShape
subclass of: Neurodevelopmental abnormality
subclass of: Developmental delay or intellectual disability

SIO_000982
type: QualityValue
notation: 106

Mandelic acid(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCMAD
editorial note: To Do: align with CHEBI.

Diet Quantity
type: Class
type: QuantityVariable
subclass of: SIO_000052
subclass of: Diet and Nutrition
definition: A quantity relating to diet and nutrition.
was approved by: PER-Jeanette-Stingone
editorial note: What differentiated diet from nutrition? That is why is this needed since we have the DietAndNutrition Class

Black Non-Hispanic
type: Class
type: QualityValue
subclass of: Non-Hispanic Ethnicity
subclass of: African American
notation: 216

times per two weeks
type: SIO_000074
type: SIO_000794
notation: times / two weeks

Unmarried
type: Class
type: QualityValue
subclass of: Marital Status
notation: 46
definition: Indicates a person not currently joined in a legally binding matrimonial union.

mono-carboxy isooctyl phthalate
type: Class
subclass of: Phthalate
notation: mCIOP

units per square meter
type: SIO_000074
notation: U/m^2

plaque forming unit
type: SIO_000074
notation: pfu

Prenatal Period
type: Class
type: NodeShape
subclass of: SIO_000417
comment: The time period prior to birth.

Mono-2-ethyl-5-oxohexylterephthalate
notation: MEOHTP

Samples Arrived Thawed and Analyzed
type: Class
subclass of: SIO_001167

Population Group
type: Class
type: QualityVariable
subclass of: StudyIndicator
definition: A group of individuals united by a common factor (e.g., geographic location, ethnicity, disease, age, gender)

Coma
type: Class
type: QualityValue
subclass of: Phenotype
notation: 124
definition: Complete absence of wakefulness and content of conscience, which manifests itself as a lack of response to any kind of external stimuli.

spinal disease
type: Class
type: NodeShape
subclass of: Neurological Issues with Spinal Cord

Pregnancy
type: Class
subclass of: SIO_000417
subclass of: Pregnancy Characteristic
subclass of: From Conception
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: Conceiving
definition: The time during which one or more offspring develops inside a woman.
was approved by: PER-Jeanette-Stingone

High School or Less
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: Education
notation: 33
definition: Education Level of High School or Less
was approved by: PER-Jeanette-Stingone

plaque forming unit per milliliter
type: SIO_000074
notation: pfu/ml

Consumed Alcohol
type: Class
type: QualityValue
subclass of: Alcohol Use
notation: 52

mono-2-heptyl phthalate
type: Class
subclass of: Phthalate
notation: mHpP

Educational Status
type: Class
subclass of: Thing

Difference of Z-Scores
type: Class
type: QualityVariable
subclass of: Physical And Mental Assessment
subclass of: Difference
subclass of: Restriction
  some values from: Class
    intersection of: Subtrahend
    intersection of: Z-Score
  on property: SIO_000008
subclass of: Restriction
  some values from: Class
    intersection of: Minuend
    intersection of: Z-Score
  on property: SIO_000008
definition: The arithmetic difference of two Z-Scores

drug other than antimalarial
type: Class
subclass of: drug
subclass of: Class
  intersection of: drug
  intersection of: Class
    complement of: Antimalarial
definition: Any drug other than an antimalarial drug

Full Time Employment
type: Class
type: QualityValue
subclass of: Occupation
notation: 64
definition: Employed for a standard number of hours of working time, at least 50% or 20 hours per week.

Gadolinium
type: Class
subclass of: Metal
notation: Gd
definition: Gadolinium. An element of the rare earth family of metals. GADOLINIUM has the atomic symbol Gd, atomic number 64, and atomic weight 157.25. Its oxide is used in the control rods of some nuclear reactors.

international units per litre
type: SIO_000074
notation: IU/L

Vitamin D
type: Class
subclass of: Biomolecule
subclass of: Diet and Nutrition
definition: Vitamin D is a group of fat-soluble prohormones, which can be obtained from sun exposure, food and supplements. Vitamin D is biologically inactive and converted to the biologically active calcitriol via double hydroxylation in the body.

Apartment
type: Class
type: QualityValue
subclass of: Living Quarters
notation: 196

Sepsis
type: Class
subclass of: SIO_010056
subclass of: Sepsis, Septic Shock, or SIRS

Earth
type: QualityValue
notation: 182

Higher Education
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: Education
notation: 31
definition: College or university education beyond the successful completion of high school or grammar school, or the attainment of an approved equivalent
was approved by: PER-Jeanette-Stingone

Date of Birth
type: Class
type: QuantityVariable
subclass of: Demographic
subclass of: SIO_000417
definition: Date of day on which a person was born.
was approved by: PER-Jeanette-Stingone

White Non-Hispanic
type: Class
type: QualityValue
subclass of: Non-Hispanic Ethnicity
subclass of: White
notation: 214

Received Drug Therapy
type: Class
subclass of: SIO_001398
subclass of: Pharmacotherapy
subclass of: Restriction
  some values from: drug
  on property: SIO_000230
notation: 360

mono-benzyl phthalate
type: Class
subclass of: Phthalate
notation: mBzP
editorial note: Is this a repeat of MBP?

colony forming unit per milliliter
type: SIO_000074
notation: cfu/ml

Asthma Induced Reduced Play Or Activity
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment
subclass of: behavioral response to pain
subclass of: Lack of spontaneous play
subclass of: Restriction
  some values from: wheezing or tightness in the chest or cough
  on property: SIO_001157

billion parts per microgram
type: SIO_000074
notation: x109 µL

Urination
type: Class
type: QualityVariable
subclass of: Biological Response
subclass of: Targeted Analyte

Bisphenol S
type: Class
subclass of: Environmental Phenol
notation: BPS

Neurodevelopmental abnormality
type: Class
type: NodeShape
subclass of: Abnormal nervous system physiology
comment: A deviation from normal of the neurological development of a child, which may include any or all of the aspects of the development of personal, social, gross or fine motor, and cognitive abilities. This term should be used to describe abnormalities with onset in the developmental period.

endocrine system disease
type: Class
subclass of: Comorbidity Disease

Never Smoked
type: Class
type: QualityValue
subclass of: Smoking Status
notation: 56
definition: The quality of never smoking in the past.
was approved by: PER-Jeanette-Stingone

Cement Floor
type: Class
type: QualityValue
subclass of: Floor Type
notation: 10
definition: Cement Floor Type
was approved by: PER-Jeanette-Stingone

Finished Elementary School
type: Class
type: QualityValue
subclass of: Finished Elementary Grade 4
notation: 15
definition: Finished Elementary School
was approved by: PER-Jim-McCusker

Eats Fresh Vegetables
type: Class
type: QualityValue
subclass of: Eating or Drinking
notation: 29
definition: Whether or not Fresh Vegetables are consumed.
was approved by: PER-Jeanette-Stingone

Body Weight Quality
type: Class
subclass of: Anthropometry
subclass of: SIO_000005
definition: A categorization of body mass relative to the height, as defined using Body Mass Index.

10^9 cells per microliter
type: SIO_000074
type: SIO_000794
notation: 10^9 cells / µL

Subtrahend
type: Class
type: QuantityVariable
subclass of: SIO_000052
definition: In a difference expression, the subtrahend is the quantity or number to be subtracted from another.

Iodine
type: Class
subclass of: Element
notation: I
definition: Iodine is a nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.

Cyclohexane-1, 2-dicarboxylic acid mono carboxyisooctyl ester (DINCH)
notation: MCOCH

Sample frozen
type: Class
subclass of: SIO_001167

microgram per liter
type: SIO_000074
notation: µg/L

granulomatosis with polyangiitis
type: Class
subclass of: Disease

Perfluorohexane-1-sulphonic acid
type: Class
subclass of: PFC
notation: PFHxS

Trunk
type: Class
subclass of: SIO_010046
definition: Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present.

dust
type: Class
subclass of: Thing

Normal Weight
type: Class
type: QualityValue
subclass of: Body Weight Quality
subclass of: Underweight/Normal
subclass of: Restriction
  some values from: Restriction
    some values from: Class
      intersection of: Body Mass Index
      intersection of: Restriction
        some values from: Datatype
        on property: STATO_0000129
    on property: SIO_000008
  on property: SIO_000011
notation: 61
definition: Adult normal weight is defined as having a BMI between 18.5 and 25 kg/m^2; Child normal weight is defined as greater than or equal to the 5th percentile but less than the 85th percentile for age, gender and height.

Gestational Age at Birth
type: Class
subclass of: Gestational Age
definition: Describes how far along a pregnancy is, usually measured in weeks, as measured at birth.
equivalent class: Class
  intersection of: Gestational Age
  intersection of: Restriction
    on property: SIO_000793
    all values from: Birth
  equivalent class: Gestational Age at Birth

disintegrations per second
type: SIO_000074
notation: dps

Minuend
type: Class
type: QuantityVariable
subclass of: SIO_000052
definition: In a difference expression, the minuend is the quantity or number from which another is to be subtracted.

Car Count
type: Class
type: QuantityVariable
subclass of: SIO_000794
subclass of: Housing Characteristic
definition: Total Number of Cars in the Home
editorial note: Again, this isn't related to physical properties of housing. This is more closely related to Socioeconomic Status. Consider moving it.

6-chloronicotinic acid
notation: CINA6

Vanadium
type: Class
subclass of: Metal
notation: V
definition: A metallic element with the atomic symbol V, atomic number 23, and atomic weight 50.94. It is used in the manufacture of vanadium steel. Prolonged exposure can lead to chronic intoxication caused by absorption usually via the lungs.

2-hydroxyphenanthrene + 3-hydroxyphenanthrene
notation: PHEN2PHEN3

Run out-of-contol; insufficient sample for repeat analysis
type: Class
subclass of: SIO_001167

mono-(2-ethyl-5-carboxypentyl) phthalate
type: Class
subclass of: Phthalate
notation: mECPP
editorial note: Duplicate of MCEPP?

mono (2-ethyl-5-oxohexyl) phthalate
type: Class
subclass of: Phthalate
notation: MEOHP

parasites per microliter
type: SIO_000074
type: SIO_000794
notation: parasites / µL

Delivery Characteristics
type: Class
subclass of: StudyIndicator
definition: Attributes related to the delivery of a child.

C-reactive protein
type: Class
subclass of: Protein
definition: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

alpha-linolenic acid
type: Class
subclass of: Fatty Acid
notation: C183N3
definition: A linolenic acid with cis-double bonds at positions 9, 12 and 15. Shown to have an antithrombotic effect.

Uranium
type: Class
subclass of: Metal
notation: U
definition: Uranium. A radioactive element of the actinide series of metals. URANIUM has an atomic symbol U, atomic number 92, and atomic weight 238.03. U-235 is used as the fissionable fuel in nuclear weapons and as fuel in nuclear power reactors.

Concentration
type: Class
type: QuantityVariable
subclass of: Laboratory Result

Fluticasone/vilanterol (Breo Ellipta)
type: Class
subclass of: Asthma Controller Medication

Asian
type: Class
type: QualityValue
subclass of: Race
subclass of: Non-White
notation: 6
definition: A person having origins in any of the original peoples of the Far East, Southeast Asia, or the Indian subcontinent, including for example, Cambodia, China, India, Japan, Korea, Malaysia, Pakistan, the Philippine Islands, Thailand, and Vietnam.
was approved by: PER-Jeanette-Stingone

Caesarian Section
type: Class
type: QualityValue
subclass of: Pregnancy Characteristic
subclass of: Route Of Delivery
notation: 20
definition: Caesarian Section Medical Procedure. One-third of pregnancies in the US end in C-Sections.

Education Grade 6
type: Class
type: QualityValue
subclass of: Some Middle School
notation: 118
definition: Finished grade 6

Eats Fast Food
type: Class
type: QualityValue
subclass of: Eating or Drinking
notation: 16
definition: Whether or not fast food is consumed.
was approved by: PER-Jeanette-Stingone

milligrams-microunits per deciliter-milliliter
type: SIO_000074
notation: (mg/dL)*(µU/mL)

Indoor Air
type: Class
subclass of: air
subclass of: Restriction
  some values from: ExO_0000019
  on property: SIO_000128

Sample older than 2 weeks
type: Class
subclass of: SIO_001167

Budesonide DPI (Pulmicort)
type: Class
subclass of: Asthma Controller Medication

Gender
type: Class
type: QualityVariable
subclass of: Demographic

Canned Food Consumption Frequency
type: Class
type: QuantityVariable
subclass of: Diet Quantity
subclass of: SIO_001367
definition: Frequency of Canned Food Consumption.
was approved by: PER-Jeanette-Stingone
editorial note: Also want to list this under Environmental Exposures (b/c canned food has chemicals in the lining so sometimes it is used as a proxy)

Cadmium
type: Class
subclass of: Metal
notation: Cd
definition: An element with atomic symbol Cd, atomic number 48, and atomic weight 114. It is a metal and ingestion will lead to CADMIUM POISONING.

volt
type: SIO_000074
notation: Volt

First Trimester
type: Class
subclass of: SIO_000417
subclass of: From Conception
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: Conceiving
definition: From pregnancy week 1 through 12 and includes conception. Conception is when the sperm fertilizes the egg. The fertilized egg then travels down the fallopian tube and attaches to the inside of the uterus, where it begins to form the embryo and placenta. The first trimester carries the highest risk of miscarriage (natural death of embryo or fetus).
was approved by: PER-Jeanette-Stingone

Beclomethasone HFA
type: Class
subclass of: Asthma Controller Medication

Education Grade 7
type: Class
type: QualityValue
subclass of: Some Middle School
notation: 119
definition: Finished grade 7

Bodily Fluid
type: Class
subclass of: Biospecimen
definition: Liquids originating from inside the bodies of living people. They include fluids that are excreted or secreted from the body, and body water that normally is not.

Outdoor Air
type: Class
subclass of: air
subclass of: Restriction
  some values from: ExO_0000020
  on property: SIO_000128

Cyclohexane-1, 2-dicarboxylic acid mono hydroxyisononyl ester (DINCH)
notation: MHNCH

Sample integrity/quality compromised preventing analysis
type: Class
subclass of: SIO_001167

Arsenic
type: Class
subclass of: Metal
notation: As
definition: A shiny gray element with atomic symbol As, atomic number 33, and atomic weight 75. It occurs throughout the universe, mostly in the form of metallic arsenides. Most forms are toxic. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), arsenic and certain arsenic compounds have been listed as known carcinogens. (From Merck Index, 11th ed)

Cord Blood
type: Class
subclass of: Pregnancy Sample
subclass of: Whole Blood
definition: Blood that remains in the placenta and in the attached umbilical cord after childbirth[WP]. [database_cross_reference: http://en.wikipedia.org/wiki/Cord_blood]

Hemoglobin Genotype AS
type: Class
type: QualityValue
subclass of: Genotype
subclass of: SCD Genotype
notation: 347

Physical Activity
type: Class
type: QuantityVariable
subclass of: Physical Activity and Fitness

mono(7-carboxyheptyl)phthalate
type: Class
subclass of: Phthalate
notation: mCHpP

Stress Frequency
type: Class
type: QualityVariable
subclass of: Mental Health
subclass of: SIO_000475
definition: How frequently a person gets stressed.
was approved by: PER-Jeanette-Stingone
editorial note: Again, we might want to link this to a specific assessment?

ADOS calibrated severity score
type: Class
type: QuantityVariable
subclass of: CAO_01168
definition: Calibrated severity score on the Total Standardized Autism Diagnostic Observation Schedule (ADOS).

Scoliosis or Spinal Surgery
type: Class
type: QualityValue
subclass of: Thing
notation: 443
equivalent class: Class
  union of: scoliosis
  union of: Spinal Surgery
  equivalent class: Scoliosis or Spinal Surgery

Overweight (BMI 25-29.9) and no hypertensive disorder and no diabetes
type: Class
type: QualityValue
subclass of: Overweight BMI
subclass of: Class
  intersection of: Overweight BMI
  intersection of: Class
    complement of: Any hypertensive disorder or any diabetes, any BMI
notation: 328

Used to take asthma control medications but no longer
type: Class
type: QualityValue
subclass of: Has taken asthma control medications
subclass of: Asthma Controller Use
subclass of: Restriction
  some values from: Used to take but no longer
  on property: SIO_000217
notation: 276

Fluticasone furoate DPI (Arnuity Ellipta)
type: Class
subclass of: Asthma Controller Medication

Duration of Central Venous Cannula Insertion
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Duration of Medical Procedure
subclass of: Restriction
  some values from: central venous cannula insertion
  on property: SIO_000215
comment: The length of time a patient undergoes a central venous cannula insertion procedure

chromosomal disease
type: Class
subclass of: Comorbidity Disease

second
type: SIO_000074
notation: s

Airborne Particulate Matter
type: Class
type: QualityVariable
subclass of: Air Pollutant

Meconium
type: Class
subclass of: Feces
subclass of: Pregnancy Sample
definition: A dark greenish mass that accumulates in the bowel during fetal life and is discharged shortly after birth. [database_cross_reference: BTO:0000838]

nanogray
type: SIO_000074
notation: nGy

Inorganic Mercury (Hg2+)
type: Class
subclass of: Mercury Species
notation: Hg2

Neurologic
type: Class
type: QualityValue
subclass of: SIO_000475
notation: 396

Cis-Nonachlor
type: Class
subclass of: Organochlorine Compound
notation: CNON

Takes asthma control medications some days but not others
type: Class
type: QualityValue
subclass of: Has taken asthma control medications
subclass of: Asthma Controller Use
subclass of: Restriction
  some values from: Takes some days but not others
  on property: SIO_000217
notation: 277

Toaster Count
type: Class
type: QuantityVariable
subclass of: Household Appliance Count
definition: Number of appliances used to toast bread.
was approved by: PER-Jeanette-Stingone

diabetes mellitus
type: Class
type: QualityValue
subclass of: Disease
notation: 342

Dead
type: Class
type: QualityValue
subclass of: Destination
notation: 173
definition: The cessation of life.

Obese (BMI >30) and no hypertensive disorder and no diabetes
type: Class
type: QualityValue
subclass of: Obese BMI
subclass of: Class
  intersection of: Obese BMI
  intersection of: Class
    complement of: Any hypertensive disorder or any diabetes, any BMI
notation: 329

Prenatal Vitamin Use
type: Class
type: QualityValue
subclass of: nutrition intake
notation: 149
definition: Prenatal vitamins are supplements that contain daily vitamins and minerals needed by mothers before and during pregnancy.

Pacific Islander or Native Hawaiian, non-Hispanic
type: Class
type: QualityValue
subclass of: Non-Hispanic Ethnicity
subclass of: Native Hawaiian or Other Pacific Islander
notation: 242

Three Months Prior to Pregnancy
type: Class
type: NodeShape
subclass of: SIO_000417
comment: A subclass of Pre-pregnancy; the three months immediately prior to conception.

Duration of Noninvasive Positive-Pressure Ventilation
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Duration of Medical Procedure
subclass of: Restriction
  some values from: noninvasive positve-pressure ventilation
  on property: SIO_000215
comment: The length of time a patient undergoes noninvasive positive-pressure ventilation

milligray
type: SIO_000074
notation: mGy

nanogram per milliliter
type: SIO_000074
notation: ng/ml

food product organismal source
type: Class
subclass of: SIO_010046

Serum
type: Class
subclass of: Blood Component
definition: Liquid derived from blood plasma that has clotting factors removed. [database_cross_reference: http://en.wikipedia.org/wiki/Serum_(blood)][database_cross_reference: http://orcid.org/0000-0002-6601-2165]

Hsap dv 0000000
type: Class
subclass of: Age

Unemployment
type: Class
type: QualityValue
subclass of: Occupation
notation: 67
definition: The state of not having a job.

PCB52
type: Class
subclass of: Polychlorobiphenyl
notation: PCB52

Bisulfite Pyrosequencing
type: Class
subclass of: Nucleic Acid Sequencing

tracheostomy
type: Class
subclass of: SIO_001024

Housing Characteristic
type: Class
subclass of: StudyIndicator
definition: Housing Characteristic Indicator Class
was approved by: PER-Jeanette-Stingone

Never takes asthma control medications
type: Class
type: QualityValue
subclass of: Asthma Controller Use
subclass of: Restriction
  some values from: Never takes
  on property: SIO_000217
notation: 274
disjoint with: Has taken asthma control medications

Soil Floor
type: Class
type: QualityValue
subclass of: Floor Type
notation: 84
definition: The flooring is made of soil.
was approved by: PER-Jeanette-Stingone

Pentachlorophenol
type: Class
subclass of: Environmental Phenol
notation: PCP
definition: An insecticide and herbicide that has also been used as a wood preservative. Pentachlorphenol is a widespread environmental pollutant. Both chronic and acute pentachlorophenol poisoning are medical concerns. The range of its biological actions is still being actively explored, but it is clearly a potent enzyme inhibitor and has been used as such as an experimental tool.

mono (6-COOH-2-methylheptyl) phthalate
type: Class
subclass of: Phthalate
notation: MCOMHP

Non-White
type: Class
type: QualityValue
subclass of: Race
notation: 149
definition: A race other than white.

Educational Status
type: Class
type: QualityVariable
subclass of: SIO_001326
subclass of: Educational Status
subclass of: Education

Stroke, Cerebral Ischemia, or Cerebral infarction
type: Class
type: QualityValue
subclass of: SIO_010056
notation: 400
equivalent class: Class
  union of: stroke
  union of: brain ischemia
  union of: cerebral infarction
  equivalent class: Stroke, Cerebral Ischemia, or Cerebral infarction

Any hypertensive disorder or any diabetes, any BMI
type: Class
type: QualityValue
subclass of: Health Outcome
notation: 330
union of: hypertension
union of: diabetes mellitus

millicurie
type: SIO_000074
notation: mCi

kilovolt-hour
type: SIO_000074
notation: kVh

Seizures
type: Class
type: QualityValue
subclass of: Phenotype
notation: 125
definition: Seizures are an intermittent abnormality of the central nervous system due to a sudden, excessive, disorderly discharge of cerebral neurons and characterized clinically by some combination of disturbance of sensation, loss of consciousness, impairment of psychic function, or convulsive movements. The term epilepsy is used to describe chronic, recurrent seizures.

kelvin
type: SIO_000074
notation: K

Part Time Employment
type: Class
type: QualityValue
subclass of: Occupation
notation: 65
definition: Employment involving less than the standard or customary working time.

Third
type: Class
subclass of: Thing

artificial respiration
type: Class
subclass of: SIO_001398

Systemic Inflammatory Response Syndrome
type: Class
subclass of: SIO_010056
subclass of: Sepsis, Septic Shock, or SIRS

Interleukin-21
type: Class
subclass of: Protein
notation: IL21

mono (7-COOH-2-methyloctyl) phthalate
type: Class
subclass of: Phthalate
notation: MCOMOP

Uses Steroid Treatment
type: Class
type: QualityValue
subclass of: Pharmacotherapy
subclass of: Restriction
  some values from: CHEBI_35341
  on property: SIO_000139
notation: 28
definition: Had a form of treatment which uses steroids.
was approved by: PER-Jeanette-Stingone

Spinal Surgery
type: Class
type: QualityVariable
subclass of: surgical procedure
subclass of: Scoliosis or Spinal Surgery
subclass of: Restriction
  some values from: spinal cord
  on property: SIO_000230

10^6 cells per microliter
type: SIO_000074
type: SIO_000794
notation: 10^6 cells / µL

Only takes asthma control medications with symptoms
type: Class
type: QualityValue
subclass of: Has taken asthma control medications
subclass of: Asthma Controller Use
subclass of: Restriction
  some values from: Only takes with symptoms
  on property: SIO_000217
notation: 275

Social Affect + Restricted and Repetitive Behavior Total
type: Class
type: QuantityVariable
subclass of: CAO_01168
definition: Total Standardized Autism Diagnostic Observation Schedule (ADOS) score.

Healthy (BMI <25) weight and no hypertensive disorder and no diabetes
type: Class
type: QualityValue
subclass of: Healthy BMI
subclass of: Class
  intersection of: Healthy BMI
  intersection of: Class
    complement of: Any hypertensive disorder or any diabetes, any BMI
notation: 327

Chromium
type: Class
subclass of: Metal
notation: Cr
definition: A trace element that plays a role in glucose metabolism. It has the atomic symbol Cr, atomic number 24, and atomic weight 52. According to the Fourth Annual Report on Carcinogens (NTP85-002, 1985), chromium and some of its compounds have been listed as known carcinogens.

nanosievert
type: SIO_000074
notation: nSv

ampere
type: SIO_000074
notation: A

Ciclesonide HFA (Alvesco)
type: Class
subclass of: Asthma Controller Medication

Student
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: Occupation
notation: 66

percentile
type: SIO_000074
notation: %

Abnormality of the spinal cord
type: Class
type: NodeShape
subclass of: Neurological Issues with Spinal Cord
comment: An abnormality of the spinal cord (myelon).

Residential Building
type: Class
type: QualityValue
type: QualityVariable
subclass of: Housing Characteristic
notation: 154

Annual Income $40,001 to $70,000
type: Class
type: QualityValue
subclass of: Household Income
notation: 207

Used Only Anti Malarials or No Medications
type: Class
type: QualityValue
subclass of: Prescription Medication and Dietary Supplements
subclass of: Drug Other Than Antimalarial Use
notation: 139

Lower Respiratory Tract Infection
type: Class
type: QualityValue
subclass of: infection
notation: 384

Received Antimalarial Therapy
type: Class
type: QualityValue
subclass of: Antimalarial Use
subclass of: Received Drug Therapy
subclass of: Restriction
  some values from: Antimalarial
  on property: SIO_000230
notation: 344

SO_0000000
deprecated: true

Small Molecule
type: Class
subclass of: Biomolecule
definition: A small molecule is a low molecular weight (< 900 daltons) organic compound that may help regulate a biological process, with a size on the order of 1 nm. Most drugs are small molecules.

dimethylphosphate
type: Class
subclass of: Alkyl Phosphate Pesticide Metabolite
notation: DMP
editorial note: To Do: align with CHEBI.

Home Ownership
type: Class
type: QuantityVariable
subclass of: Demographic
definition: Who owns the home they live in.

Rheumatology disorder (SLE, Wegeners, JRA)
type: Class
type: QualityValue
subclass of: Disease
notation: 398
equivalent class: Class
  union of: granulomatosis with polyangiitis
  union of: juvenile rheumatoid arthritis
  union of: systemic lupus erythematosus
  equivalent class: Rheumatology disorder (SLE, Wegeners, JRA)

Takes some days but not others
type: Class
subclass of: SIO_001290

candela
type: SIO_000074
notation: cd

Disease
type: Class
subclass of: SIO_010299
subclass of: Health Outcome

disintegrations per minute
type: SIO_000074
notation: dpm

Cromolyn
type: Class
subclass of: Asthma Controller Medication

SIO_000554
type: QualityValue
notation: 134

Sleep disturbance
type: Class
subclass of: SIO_000475

Insulin
type: Class
subclass of: Protein
subclass of: Metabolite
definition: A peptide hormone produced in the pancreas and involved in regulating the metabolism of carbohydrates (particularly glucose) and fats. Commonly thought of as a protein, it consists of two petide chains, one containing 21 amino acid residues and the other containing 30; the chains are joined together by 2 disulfide bonds. Recombinant insulin is identical to human insulin, but is synthesised by inserting the human insulin gene into E. coli, which then produces insulin for human use. It is used in the treatment of type I and type II diabetes.

3-phenoxybenzoic acid
type: Class
subclass of: Metabolite
definition: A phenoxybenzoic acid in which the phenoxy group is meta to the carboxy group. It is a metabolite of pyrethroid insecticides.

Biomolecule
type: Class
subclass of: Biospecimen
definition: A biospecimen that is composed of molecular entities.

Received Drug Therapy Other Than Antimalarials
type: Class
type: QualityValue
subclass of: Drug Other Than Antimalarial Use
subclass of: Received Drug Therapy
subclass of: Restriction
  some values from: drug other than antimalarial
  on property: SIO_000230
notation: 345

dimethylthiophosphate
type: Class
subclass of: Alkyl Phosphate Pesticide Metabolite
notation: DMTP
editorial note: To Do: align with CHEBI.

Annual Income More Than $70,001
type: Class
type: QualityValue
subclass of: Annual Income More Than $60,000
notation: 208

Takes every day
type: Class
subclass of: SIO_001292

Smoker
type: Class
type: QualityValue
subclass of: Smoking Status
notation: 105
definition: The quality of smoking cigarettes.

neurological dysfunction
type: Class
subclass of: Comorbidity Disease

Renter
type: Class
type: QualityValue
subclass of: Home Ownership
notation: 148
definition: This person rents the home they live in.

Sepsis, Septic Shock, or SIRS
type: Class
type: QualityValue
subclass of: SIO_010056
notation: 399
equivalent class: Class
  union of: Sepsis
  union of: septic shock
  union of: Systemic Inflammatory Response Syndrome
  equivalent class: Sepsis, Septic Shock, or SIRS

microcurie
type: SIO_000074
notation: µCi

mole
type: SIO_000074
notation: mol

milliunits per milliliter
type: SIO_000074
notation: mU/ml

Dimethylarsinic Acid
type: Class
subclass of: Arsenic Species
notation: Dimethylarsinic Acid

Inflammatory abnormality of the skin
type: Class
type: NodeShape
subclass of: Health Outcome
subclass of: DOID 37
comment: The presence of inflammation of the skin. That is, an abnormality of the skin resulting from the local accumulation of fluid, plasma proteins, and leukocytes.

Employment
type: Class
type: QualityValue
subclass of: Occupation
notation: 245

Perfluorooctanesulfonamide
type: Class
subclass of: PFC
notation: PFOSA

type 2 diabetes mellitus
type: Class
type: QualityValue
subclass of: diabetes mellitus
notation: 181

Asthma Related Clinic Visit
type: Class
type: QuantityVariable
subclass of: Healthcare Access
subclass of: Clinical Encounter
subclass of: Restriction
  some values from: asthma
  on property: SIO_000635

Cotinine (total)
type: Class
subclass of: Tobacco Metabolite
notation: COTT
editorial note: To Do: align with CHEBI.

Tobacco Smoke Exposure
type: Class
type: QualityValue
subclass of: Environmental Exposure
notation: 98

Annual Income $10,001 to $20,000
type: Class
type: QualityValue
subclass of: Household Income
notation: 205

Only takes with symptoms
type: Class
subclass of: SIO_001290

Interleukin-5
type: Class
subclass of: Protein
notation: IL5

Relative
type: Class
subclass of: Demographic
subclass of: SIO_000016
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: Restriction
      on property: hasRole
      all values from: Relative
    intersection of: SIO_000485
definition: Broadly, kinship patterns may be considered to include people related by both descent – i.e. social relations during development – and by marriage. Human kinship relations through marriage are commonly called "affinity" in contrast to the relationships that arise in one's group of origin, which may be called one's descent group. In some cultures, kinship relationships may be considered to extend out to people an individual has economic or political relationships with, or other forms of social connections. Within a culture, some descent groups may be considered to lead back to gods or animal ancestors (totems). This may be conceived of on a more or less literal basis.
was approved by: PER-Jeanette-Stingone

diethylthiophosphate
type: Class
subclass of: Alkyl Phosphate Pesticide Metabolite
notation: DETP
editorial note: To Do: align with CHEBI.

micrometer
type: SIO_000074
notation: µm

Vineland Testing
type: Class
subclass of: Childhood Followup
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: Childhood Period
definition: The time period when the Vineland early childhood development testing is administered to a subject.

RNA
type: Class
subclass of: Macromolecule

Screening Test
type: Class
subclass of: Test

kilobyte
type: SIO_000074
notation: kB

microliter
type: SIO_000074
notation: µl

millimeter
type: SIO_000074
notation: mm

Interleukin-4
type: Class
subclass of: Protein
notation: IL4

PAH
type: Class
subclass of: Volatile Organic Compound

tetracosanoic acid
type: Class
subclass of: Fatty Acid
notation: C240
definition: A C24 straight-chain saturated fatty acid.

Cousin
type: Class
type: QualityValue
subclass of: Relative
subclass of: SIO_000287
notation: 354
definition: A person belonging to the same extended family.

Tri-Cell DMA-80 Direct Mercury Analyzer
type: Class
subclass of: Direct Mercury Analyzer
definition: The DMA-80 is based on the principles of sample thermal decomposition, mercury amalgamation and atomic absorption detection. The DMA-80 has been used to develop the US EPA method 7473 (Mercury in solids and solutions by thermal decomposition, amalgamation, and atomic absorption spectrophotometry). It is furthermore compliant with ASTM method D-6722-01 (Total mercury in coal and coal combustion residues) and ASTM method D-7623-10 (Total mercury in crude oil).
was approved by: PER-Jim-McCusker

dimethyldithiophosphate
type: Class
subclass of: Alkyl Phosphate Pesticide Metabolite
notation: DMDP
editorial note: To Do: align with CHEBI.

C-C motif chemokine 20
type: Class
subclass of: Protein
notation: MIP3A

Annual Income $20,001 to $40,000
type: Class
type: QualityValue
subclass of: Household Income
notation: 206

Severe Malarial Anemia
type: Class
type: QualityValue
subclass of: Anemia
notation: 127
definition: In holoendemic transmission areas, Severe Malarial Anemia (SMA) is the primary clinical manifestation of severe childhood malaria, with cerebral malaria occurring only in rare cases. Mortality rates from SMA can exceed 30% in pediatric populations residing in holoendemic transmission areas. The pathophysiological processes that contribute to SMA involve direct and indirect destruction of parasitized and non-parasitized red blood cells (RBCs), inefficient and/or suppression of erythropoiesis, and dyserythropoiesis.

Non-infectious Respiratory Distress
type: Class
type: QualityValue
subclass of: Respiratory distress
notation: 397
equivalent class: Class
  intersection of: Respiratory distress
  intersection of: Class
    complement of: Restriction
      some values from: Infectious Disorder
      on property: SIO_001157
  equivalent class: Non-infectious Respiratory Distress

Mullens Testing
type: Class
subclass of: Childhood Followup
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: Childhood Period
definition: The time period when the Mullens early childhood development testing is administered to a subject.

Used to take but no longer
type: Class
subclass of: SIO_001288

byte
type: SIO_000074
notation: Byte

counts per minute
type: SIO_000074
notation: cpm

centimeter
type: SIO_000074
notation: cm

cubic decimeter
type: SIO_000074
notation: dm3

Agreement Answer
type: Class
type: NodeShape
subclass of: SIO_000965
comment: A response about an individual's agreement about something. [Definition Source: NCI]

Ethyl paraben
type: Class
subclass of: Paraben
notation: EtPB
definition: Ethylparaben is a Standardized Chemical Allergen. The physiologic effect of ethylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity. The chemical classification of ethylparaben is Allergens.

liver disease
type: Class
subclass of: Comorbidity Disease

Composite Score
type: Class
type: QualityVariable
subclass of: Physical And Mental Assessment
subclass of: Score
definition: A single value that is calculated from multiple scores. This composite score can then be used as a single variable in further analysis and comparison. [def-source: NCI]

Trauma Related Hospital Admission
type: Class
type: QualityValue
subclass of: Restriction
  some values from: injury
  on property: SIO_001157
subclass of: Hospital Admission By Admission Type
notation: 378

Blinded Season 2 Group
type: Class
type: QualityValue
subclass of: Seasonal Population Group
notation: 299

FEV1 Best Value
type: Class
type: QualityVariable
subclass of: CMO_0000254
subclass of: Restriction
  on property: hasUnit
  has value: liter
definition: The best FEV1 value achieved by a subject during a series of FEV1 measurements.

Duration of Muscle Relaxant Use
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Prescription Medication and Dietary Supplements
subclass of: Duration of Medical Intervention
subclass of: Restriction
  some values from: Uses Muscle Relaxants
  on property: SIO_000215
comment: The length of time a patient is taking muscle relaxants as a medical intervention

mono (3-carboxypropyl) phthalate (multiple)
type: Class
subclass of: Phthalate
notation: MCPP

Absorbance Reader
type: Class
subclass of: Microplate Reader
definition: Absorbance readers are used for assays such as ELISA assays, protein and nucleic acid quantification or enzyme activity assays. A light source illuminates the sample using a specific wavelength (selected by an optical filter, or a monochromator), and a light detector located on the other side of the well measures how much of the initial (100%) light is transmitted through the sample: the amount of transmitted light will typically be related to the concentration of the molecule of interest.
was approved by: PER-Jim-McCusker

Child Stress Assessment
type: Class
type: NodeShape
subclass of: Physical And Mental Assessment
subclass of: Assessment
subclass of: Restriction
  some values from: CAO_00518
  on property: SIO_000215
subclass of: Restriction
  some values from: Child
  on property: SIO_000139
comment: A qualitative assessment of the level of stress experienced by a child.

days per week
type: Class
type: NodeShape
subclass of: UO_0000280

Interfering substances present
type: Class
subclass of: SIO_001167

Ruthenium
type: Class
subclass of: Metal
notation: Ru
definition: RUTHENIUM is a hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.

milliliter
type: SIO_000074
notation: ml

N-Acetyl-S-(3-hydroxypropyl-1-methyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: HPMMA
editorial note: To Do: align with CHEBI.

FEV1 Predicted Value
type: Class
type: QualityVariable
subclass of: CMO_0000254
subclass of: Restriction
  on property: hasUnit
  has value: liter
definition: The expected or predicted FEV1 value for a patient based on their demographics (typically age, height, sex, and race) and comparison with a population control group.

Blinded Season 3 Group
type: Class
type: QualityValue
subclass of: Seasonal Population Group
notation: 300

Rhinorrhea
type: Class
type: NodeShape
subclass of: Sneezing, Runny Nose, or Congestion
comment: Increased discharge of mucus from the nose.

Surgery Related Hospital Admission
type: Class
type: QualityValue
subclass of: Restriction
  some values from: surgical procedure
  on property: SIO_000243
subclass of: Hospital Admission By Admission Type
notation: 376

Duration of Antibiotic Use
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Prescription Medication and Dietary Supplements
subclass of: Duration of Medical Intervention
subclass of: Restriction
  some values from: Uses Antibiotics
  on property: SIO_000215
comment: The length of time a patient receives antibiotic treatment as a medical intervention

valid measurement
type: Class
type: QualityValue
subclass of: SIO_001167
subclass of: Measurement
notation: 351

5-iso Prostaglandin F2 alpha-VI
type: Class
subclass of: Targeted Analyte
notation: F2AVI

Never Feels Stressed
type: Class
type: NodeShape
subclass of: SIO_001289
subclass of: Child Stress Assessment

Initial concentration higher than the highest standard, insufficient volume for repeat analysis (93, 18)
type: Class
subclass of: SIO_001167

N-Ethyl Perfluorooctane sulfonamido acetic acid
notation: NETFOSAA

Diagnosis Group
type: Class
type: QualityVariable
subclass of: Demographic
subclass of: Health Outcome

N-Acetyl-S-(4-hydroxy-2-buten-1-yl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: MHBMA3
editorial note: To Do: align with CHEBI.

cubic centimeter
type: SIO_000074
notation: cm3

smoking behavior
type: Class
type: NodeShape
subclass of: Alcohol, Tobacco, and Illicit Drug Use
subclass of: GO_0007610

Cerebrospinal fluid
type: Class
subclass of: SIO_010046
definition: A clear, colorless fluid that is found in the brain and spinal cord.

Specific Gravity
type: Class
type: QuantityVariable
subclass of: SIO_001018
subclass of: Targeted Analyte
definition: Specific gravity is the ratio of the density of a substance to the density of a reference substance; equivalently, it is the ratio of the mass of a substance to the mass of a reference substance for the same given volume. Apparent specific gravity is the ratio of the weight of a volume of the substance to the weight of an equal volume of the reference substance. The reference substance is nearly always water at its densest (4°C) for liquids; for gases it is air at room temperature (21°C). Nonetheless, the temperature and pressure must be specified for both the sample and the reference. Pressure is nearly always 1 atm (101.325 kPa). Temperatures for both sample and reference vary from industry to industry.
editorial note: Why is this here? Maybe it belongs in another list

Duration of Medical Intervention
type: Class
type: NodeShape
subclass of: PATO_0001309
subclass of: Restriction
  some values from: SIO_001398
  on property: SIO_000215
comment: The length of time a patient receives some form of medical intervention

FVC Best Value
type: Class
type: QualityVariable
subclass of: CMO_0000251
subclass of: Restriction
  on property: hasUnit
  has value: liter
definition: The best FVC value achieved by a subject during a series of FVC measurements.

Pre-Pregnancy and Pregnancy Month 1
type: Class
subclass of: SIO_000417
definition: The time period that begins three months prior to conception and ends at the end of the first month of pregnancy.

symptom
type: Class
subclass of: SIO_010056

Hospital ER Admission
type: Class
type: QualityValue
subclass of: Restriction
  some values from: Hospital Emergency Room
  on property: SIO_000061
subclass of: Hospital Admission
comment: This class denotes an ER admission that results in a hospital admission as well.
notation: 371

Childhood Cohort Study
type: Class
subclass of: CohortStudy

Asthma Related Hospitalization
type: Class
type: QuantityVariable
subclass of: Healthcare Access
subclass of: Hospitalization
subclass of: Restriction
  some values from: asthma
  on property: SIO_000635

Assisted Reproductive Therapy
type: Class
type: QualityValue
subclass of: Pregnancy Characteristic
notation: 7

Kaufman ABC
type: Class
subclass of: Neurocognitive Assessment
definition: culturally fair, cognitive ability test for children

2, 2'-dihydroxy-methoxybenzophenone
type: Class
notation: BP8

Household
type: Class
subclass of: SIO_001064
subclass of: Housing Characteristic
definition: A household consists of one or more people who live in the same dwelling and also share meals or living accommodation, and may consist of a single family or some other grouping of people. A single dwelling will be considered to contain multiple households if either meals or living space are not shared. The household is the basic unit of analysis in many social, microeconomic and government models, and is important to the fields of economics and inheritance.

mass density unit
type: SIO_000074
notation: mdu

Smoking Status
type: Class
type: QualityValue
type: QualityVariable
subclass of: SIO_001326
subclass of: Alcohol, Tobacco, and Illicit Drug Use
subclass of: health status
notation: 197
definition: An indication of a person's current tobacco and nicotine consumption as well as some indication of smoking history
editorial note: We need to discuss this entire hierarchy.

PM 10
type: Class
subclass of: Environmental Exposure

environmental tobacco smoke exposure measurement
type: Class
type: QualityValue
subclass of: Alcohol, Tobacco, and Illicit Drug Use
subclass of: environmental exposure measurement
notation: 153

FVC Predicted Value
type: Class
type: QualityVariable
subclass of: CMO_0000251
subclass of: Restriction
  on property: hasUnit
  has value: liter
definition: The expected or predicted FVC value for a patient based on their demographics (typically age, height, sex, and race) and comparison with a population control group.

Clinical Encounter
type: Class
subclass of: Thing

Hospital Emergency Room
type: Class
subclass of: Restriction
  some values from: Hospital
  on property: SIO_000061
subclass of: Emergency Medical Services Facility

Duration of Oxygen Treatment
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Duration of Medical Intervention
subclass of: Restriction
  some values from: Oxygen Treatment
  on property: SIO_000215
comment: The length of time a patient is receiving oxygen treatment as a medical intervention

Development Quotient
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment
subclass of: Quotient
definition: A development quotient is a numerical indicator of a (infant to preschool age) child's growth to maturity across a range of psychosocial competencies.

Blinded Season 1 Group
type: Class
type: QualityValue
subclass of: Seasonal Population Group
notation: 298

Alcohol Use
type: Class
type: QualityValue
subclass of: Alcohol, Tobacco, and Illicit Drug Use
notation: 83
definition: Uses Alcohol

Irregular result, no concentration reported
type: Class
subclass of: SIO_001167

central nervous system infection
type: Class
type: QualityValue
subclass of: infection
notation: 402

liter
type: SIO_000074
notation: L

kilogram per meter
type: SIO_000074
notation: kg/m

Methyl mercury (CH3Hg+)
type: Class
subclass of: Mercury Species
notation: CH3Hg

mono (2-ethyl-5-hydroxyhexyl) phthalate
type: Class
subclass of: Phthalate
notation: MEHHP

Respiratory distress
type: Class
subclass of: SIO_000475

food transformation process
type: Class
type: NodeShape
subclass of: Process
comment: A process involving the physical transformation of a food source or food product into some derived organic material or food product

E-Cigarette Use
type: Class
type: QualityVariable
subclass of: Active Smoker

Hemoglobin
type: Class
subclass of: Protein
definition: The iron-containing oxygen-transport metalloprotein in the red blood cells of all vertebrates (with the exception of the fish family Channichthyidae), as well as the tissues of some invertebrates. Hemoglobin in the blood carries oxygen from the respiratory organs (lungs or gills) to the rest of the body (i.e. the tissues). There it releases the oxygen to permit aerobic respiration to provide energy to power the functions of the organism in the process called metabolism.
was approved by: PER-Jim-McCusker

Number of Smokers in Household
type: Class
type: NodeShape
subclass of: SIO_000794
subclass of: Restriction
  some values from: Household
  on property: SIO_000215
comment: The number of smokers who live in a household

Childhood Year 1
type: Class
subclass of: Childhood Period
definition: The time period of a child that begins at birth and ends after one year

Pediatric Intensive Care Unit
type: Class
type: QualityValue
subclass of: Intensive Care Unit

environmental e-cigarette smoke exposure
type: Class
type: QualityVariable
subclass of: Alcohol, Tobacco, and Illicit Drug Use
subclass of: environmental exposure measurement
definition: Exposure to secondhand smoke via e-cigarettes

Inductively Coupled Plasma Mass Spectrometry
type: Class
subclass of: MassSpectrometry

Hospital Discharge By Oxygen Use
type: Class
type: QualityVariable
type: NodeShape
subclass of: Hospital Discharge
comment: A subclass of ICU Discharge; this class differentiates between whether or not a patient is discharged from a hospital on oxygen.

area density unit
type: SIO_000074
notation: adu

percent
type: SIO_000074
notation: %

millimetres of mercury
type: SIO_000074
notation: mmHg

Homemaker
type: Class
type: QualityValue
subclass of: Occupation
notation: 68
definition: A person who manages a home as their main daily activity.

spinal cord disease
type: Class
type: NodeShape
subclass of: Neurological Issues with Spinal Cord

Childhood Year 2 and Later
type: Class
subclass of: Childhood Period
definition: The time period that begins at the beginning of a child's second year and ends at the end of childhood.

E-Cigarette Puffs Per Day
type: SIO_000074

Asthma Severity Index Composite Score (CASI)
type: Class
type: QualityVariable
subclass of: Physical And Mental Assessment
subclass of: Health Outcome
subclass of: Clinical Observations Severity
subclass of: Composite Score
definition: The Composite Asthma Severity Index (CASI) is a comprehensive severity scale combining multiple facets of asthma severity: impairment, risk, and treatment The CASI score, which was developed as a research tool for intervention studies, ranges from 0 to 20 points, with higher scores indicating higher levels of severity, and includes 5 domains: day symptoms and albuterol use, night symptoms and albuterol use, controller treatment, lung function measures, and exacerbations. (Source: Minimally Important Differences and Risk Levels for the Composite Asthma Severity Index Rebecca Z. Krouse, et al.)

Interleukin-23 subunit alpha
type: Class
subclass of: Protein
notation: IL23

Icteric
type: Class
subclass of: SIO_001167

Matched Pair of Subjects
type: Class
subclass of: SIO_000616
definition: A set of 2 subjects which result from a pairing process which assigns subject to a set based on a pairing rule/criteria

microbiome richness
type: Class
type: QuantityVariable
subclass of: SIO_000052
subclass of: Physical And Mental Assessment
subclass of: Health Outcome
subclass of: community species diversity
comment: Microbiome richness is the total number of bacterial species in a microbiome.

Hospital Discharge Not On Oxygen
type: Class
type: QualityValue
type: NodeShape
subclass of: Hospital Discharge By Oxygen Use
subclass of: Class
  complement of: Restriction
    some values from: Oxygen Treatment
    on property: SIO_000250
comment: An event in which a patient is discharged from a hospital and is not given oxygen treatment.
notation: 440
equivalent class: Class
  intersection of: Hospital Discharge
  intersection of: Class
    complement of: Restriction
      some values from: Oxygen Treatment
      on property: SIO_000250
  equivalent class: Hospital Discharge Not On Oxygen
disjoint with: Hospital Discharge On Oxygen

Tooth
type: Class
subclass of: Tissue
definition: Skeletal element within the mouth (or in some species, upper part of the digestive tract) that is composed of dentine and is used in procuring or masticating food. [database_cross_reference: http://orcid.org/0000-0002-6601-2165][database_cross_reference: http://en.wikipedia.org/wiki/Tooth_(animal)]

Allergic rhinitis
type: Class
type: NodeShape
subclass of: Allergy
comment: It is characterized by one or more symptoms including sneezing, itching, nasal congestion, and rhinorrhea.

microliters per minute
type: SIO_000074
notation: µL/min

White
type: Class
subclass of: Thing

Takes asthma control medications every day
type: Class
type: QualityValue
subclass of: Has taken asthma control medications
subclass of: Asthma Controller Use
subclass of: Restriction
  some values from: Takes every day
  on property: SIO_000217
notation: 278

Tobacco Metabolite
type: Class
subclass of: Targeted Analyte

Age Equivalent
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment
subclass of: Score
definition: Age Equivalent is the individual's ability; skill, knowledge, or measurement expressed as the age at which most individuals reach the same level (age norm). The Age Norm is the average score of a particular test completed by children of a given chronological age.

ICU Discharge By Oxygen Use
type: Class
type: NodeShape
subclass of: ICU Discharge
comment: A subclass of ICU Discharge; this class differentiates between whether or not a patient is discharged from the ICU on oxygen.

Ever exposed to second hand smoke
type: Class
type: QualityValue
type: NodeShape
subclass of: environmental tobacco smoke exposure measurement
comment: Ever exposed to second hand smoke
notation: 408

cigarettes per day
type: SIO_000074
notation: cigs / day

Initial concentration higher than the highest standard
type: Class
subclass of: SIO_001167

Uses Cannabinoids
type: Class
type: QualityValue
subclass of: Consumption Behavior
subclass of: Restriction
  some values from: CHEBI_67194
  on property: SIO_000230
notation: 330

2, 2'-bis(4-hydroxyphenyl)butane
type: Class
notation: BPB

count unit
type: SIO_000074
notation: count

cis-vaccenic acid
type: Class
subclass of: Fatty Acid
notation: C181N7
definition: The cis isomer of vaccenic acid.

Supper
type: Class
type: NodeShape
subclass of: Meal
comment: The evening meal, usually the main meal of the day.

microgray
type: SIO_000074
notation: µGy

microgram per milliliter
type: SIO_000074
notation: µg/ml

Obese
type: Class
type: QualityValue
subclass of: Body Weight Quality
subclass of: Restriction
  some values from: Restriction
    some values from: Class
      intersection of: Body Mass Index
      intersection of: Restriction
        some values from: Datatype
        on property: STATO_0000129
    on property: SIO_000008
  on property: SIO_000011
notation: 63

Alternaria
type: Class
subclass of: Thing

Ultra High Performance Liquid Chromatography Instrument
type: Class
subclass of: High-Performance Liquid Chromatography
definition: Modern HPLC systems have been improved to work at much higher pressures, and therefore are able to use much smaller particle sizes in the columns (<2 μm). These "Ultra High Performance Liquid Chromatography" systems or UHPLCs can work at up to 120 MPa (17, 405 lbf/in^2), or about 1200 atmospheres.
was approved by: PER-Jim-McCusker

2-hydroxychrysene
type: Class
subclass of: PAH
notation: CHRY2

Metalloproteinase inhibitor 1
type: Class
subclass of: Protein
notation: TIMP1

Frequently exposed to second hand smoke
type: Class
type: QualityValue
type: NodeShape
subclass of: Ever exposed to second hand smoke
comment: Frequently exposed to second hand smoke
notation: 407

Mean Concentration
type: Class
type: QuantityVariable
subclass of: SIO_001109
subclass of: Concentration
definition: The mean aggregate of multiple concentration measurements of a single substance within a compound substance.

Human Dwelling
type: Class
type: QualityVariable
subclass of: Housing Characteristic
definition: Any enclosed space that may be considered a human residence, considered broadly. Positive examples include Moble Homes, Single Family Homes, Apartment Buildings, Cars, Garages, Campgrounds, etc.

Ventilator Free Respiration
type: Class
subclass of: respiration
comment: Resipration that is not aided by a mechanical ventilator.
equivalent class: Class
  intersection of: respiration
  intersection of: Class
    complement of: Restriction
      some values from: invasive mechanical ventilation
      on property: SIO_001157
  equivalent class: Ventilator Free Respiration
disjoint with: Invasive Mechanical Ventilator Assisted Respiration

ICU Discharge Not On Oxygen
type: Class
type: QualityValue
type: NodeShape
subclass of: ICU Discharge By Oxygen Use
subclass of: Class
  complement of: Restriction
    some values from: Oxygen Treatment
    on property: SIO_000250
comment: An event in which a patient is discharged from an intensive care unit and is not given oxygen treatment.
notation: 439
equivalent class: Class
  intersection of: ICU Discharge
  intersection of: Class
    complement of: Restriction
      some values from: Oxygen Treatment
      on property: SIO_000250
  equivalent class: ICU Discharge Not On Oxygen
disjoint with: ICU Discharge On Oxygen

Pre-Pregnancy and Pregnancy
type: Class
subclass of: SIO_000417
definition: The time period that begins three months prior to conception and ends at the birth of a child.

Infrared Multiphoton Dissociation (IRMPD)
type: Class
subclass of: TandemMassSpectrometry

4-Chlorophenol
type: Class
subclass of: Environmental Phenol
notation: MCP4
definition: P-chlorophenol is a white crystals with a strong phenol odor. Slightly soluble to soluble in water, depending on the isomer, and denser than water. Noncombustible. Used as an intermediate in organic synthesis of dyes and drugs.

Lunch
type: Class
type: NodeShape
subclass of: Meal
comment: A midday meal sometimes also called dinner.

milligram per liter
type: SIO_000074
notation: mg/L

Nicotine-N-oxide
type: Class
subclass of: Tobacco Metabolite
notation: NICO

Roentgen equivalent man
type: SIO_000074
notation: rem

School Breakfast
type: Class
type: NodeShape
subclass of: Breakfast
subclass of: Restriction
  some values from: school
  on property: SIO_000061
comment: Breakfast meal prepared by, and served at school.

Overweight
type: Class
type: QualityValue
subclass of: Body Weight Quality
subclass of: Restriction
  some values from: Restriction
    some values from: Class
      intersection of: Body Mass Index
      intersection of: Restriction
        some values from: Datatype
        on property: STATO_0000129
    on property: SIO_000008
  on property: SIO_000011
notation: 71

formazin nephelometric unit
type: SIO_000074
notation: FNU

Chief Complaint
type: Class
type: QualityVariable
subclass of: Health Outcome

Molybdenum
type: Class
subclass of: Metal
notation: Mo
definition: MOLYBDENUM is a metallic element with the atomic symbol Mo, atomic number 42, and atomic weight 95.94. It is an essential trace element, being a component of the enzymes xanthine oxidase, aldehyde oxidase, and nitrate reductase. (From Dorland, 27th ed)

N-Acetyl-S-(2-carbamoylethyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: AAMA
editorial note: To Do: align with CHEBI.

Biological Response
type: Class
subclass of: StudyIndicator
definition: Indicator of biological response to environmental exposure
editorial note: abolic_SDD_v1.xlsx

active eosinophilic esophagitis
type: Class
subclass of: eosinophilic esophagitis
comment: Eosinophilic esophagitis is active when a biopsy of the esophagus reveals a count of more than 25 eosinophils per high-power field area, or 0.158 mm^2 (400x).
equivalent class: Restriction
  on property: SIO_001280
  equivalent class: active eosinophilic esophagitis
  all values from: Class
    intersection of: Esophagus
    intersection of: Restriction
      some values from: Class
        intersection of: eosinophils per high-power field
        intersection of: Restriction
      on property: SIO_000008

asthma
type: Class
type: QualityValue
subclass of: bronchial disease
subclass of: Comorbidity Disease
notation: 193

thawed and clotted
type: Class
subclass of: SIO_001167

PCB180
type: Class
subclass of: Polychlorobiphenyl
notation: PCB180

Second
type: Class
subclass of: Thing

cubic centimeter per mole
type: SIO_000074
notation: cm3/mol

Interleukin-17A
type: Class
subclass of: Protein
notation: IL17A

School Lunch
type: Class
type: NodeShape
subclass of: Lunch
subclass of: Restriction
  some values from: school
  on property: SIO_000061
comment: Lunch meal prepared by, and served at school.

allergen
type: Class
subclass of: Thing

metal container
type: Class
type: NodeShape
subclass of: OBI_0000967

Fatty Acid
type: Class
subclass of: Targeted Analyte
definition: Any aliphatic monocarboxylic acid derived from or contained in esterified form in an animal or vegetable fat, oil or wax.

Interleukin-8
type: Class
subclass of: Biological Response
notation: IL8

N-Acetyl-S-(2-cyanoethyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: CYMA
editorial note: To Do: align with CHEBI.

Below LOD, results repeated and confirmed (37, 33)
type: Class
subclass of: SIO_001167

eosinophilic esophagitis in remission
type: Class
subclass of: eosinophilic esophagitis
comment: Eosinophilic esophagitis is active when a biopsy of the esophagus reveals a count of less than 15 eosinophils per high-power field area, or 0.158 mm^2 (400x).
equivalent class: Restriction
  on property: SIO_001280
  equivalent class: eosinophilic esophagitis in remission
  all values from: Class
    intersection of: Esophagus
    intersection of: Restriction
      some values from: Class
        intersection of: eosinophils per high-power field
        intersection of: Restriction
      on property: SIO_000008

Preschool
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: Education Grade
notation: 112
definition: Finished preschool

quantity of sample insufficient for analysis
type: Class
subclass of: SIO_001167

type 1 diabetes mellitus
type: Class
type: QualityValue
subclass of: diabetes mellitus
notation: 180

Very Poorly Controlled Asthma
type: Class
type: QualityValue
subclass of: Health Outcome
subclass of: asthma
subclass of: SIO_001294
notation: 295

Family history
type: Class
type: QualityVariable
subclass of: Medical History

sequence_attribute
type: Class
type: NodeShape
subclass of: SIO_000030

Perfluoroheptanoic acid
type: Class
subclass of: PFC
notation: PFHPA

Difference of POPC Scores
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment
subclass of: Difference
subclass of: Restriction
  some values from: Class
    intersection of: Subtrahend
    intersection of: Pediatric Overall Performance Category
  on property: SIO_000008
subclass of: Restriction
  some values from: Class
    intersection of: Minuend
    intersection of: Pediatric Overall Performance Category
  on property: SIO_000008
comment: The arithemetic difference of two Pediatric Overall Performance Category scores.

Canned Food Product
type: Class
type: NodeShape
subclass of: food product
subclass of: Restriction
  some values from: metal container
  on property: SIO_000128
equivalent class: Class

Annulled
type: Class
type: QualityValue
subclass of: Never Married
notation: 43
definition: A marital status in which a voidable marriage is legally declared null and void, as though it never existed. Specific grounds for annullment vary within the presiding jurisdiction, whether geographic or religious.

Public Insurance
type: Class
type: QualityValue
subclass of: Insurance
notation: 79

Preschool Child Behavior Checklist
type: Class
subclass of: Neurocognitive Assessment
definition: Child Behavior Checklist for ages 1 ½ through 5

N-Acetyl-S-(2-Carbxyethyl)-L-Cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCCEM
editorial note: To Do: align with CHEBI.

Birth Outcome
type: Class
subclass of: StudyIndicator
definition: Birth Outcomes Indicator Class
was approved by: PER-Jeanette-Stingone

Targeted Sequencing
type: Class
subclass of: Nucleic Acid Sequencing
definition: Nucleic acid sequencing that limits the scope of sequencing by filtering out portions of the nucleic acids that do not meet some criteria.

thawed, hemolyzed (covers all three levels) and exposed to light
type: Class
subclass of: SIO_001167

turns per second
type: SIO_000074
notation: 1/s

Arsenic (V) Acid
type: Class
subclass of: Arsenic Species
notation: Arsenic (V) Acid

Eats School Lunch
type: Class
type: NodeShape
subclass of: Eating or Drinking
subclass of: Diet and Nutrition
subclass of: Restriction
  some values from: School Lunch
  on property: SIO_000230
comment: The act of eating a school prepared lunch.

Transplantation
type: Class
type: QualityValue
subclass of: Comorbidity Disease
notation: 401

Benzophenone-1
type: Class
subclass of: Benzophenone
notation: BP1

Interlocutory Marital Status
type: Class
type: QualityValue
subclass of: Marital Status
notation: 44
definition: The condition existing when an order or judgement is considered temporary until either a specified period of time has passed or specific information is provided to assist in rendering a permanent decision.

Pregnancy Cohort Study
type: Class
subclass of: CohortStudy

N-Acetyl-S-(2-carbamoyl-2-hydroxyethyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: GAMA
editorial note: To Do: align with CHEBI.

Triple Quadrupole Inductively Coupled Plasma Mass Spectrometer
type: Class
subclass of: Inductively Coupled Plasma Mass Spectrometer
definition: A tandem mass spectrometer consisting of two quadrupole mass analyzers in series, with a (non-mass-resolving) radio frequency (RF)–only quadrupole between them to act as a cell for collision-induced dissociation.
was approved by: PER-Jim-McCusker

Birth Cohort Study
type: Class
subclass of: CohortStudy

thawed and hemolyzed (covers all three levels)
type: Class
subclass of: SIO_001167

PCB153
type: Class
subclass of: Polychlorobiphenyl
notation: PCB153

Benzene
type: Class
subclass of: Volatile Organic Compound
notation: BZ
definition: Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.

vascular malformation
type: Class
subclass of: Phenotypic abnormality

Silver
type: Class
subclass of: Metal
notation: Ag
definition: Silver. An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.

kilogram meter per second
type: SIO_000074
notation: kg.m/s

Race or Ethnicity Combined
type: Class
type: QualityVariable
subclass of: Demographic
definition: Race or ethinicity as a combined concept.
equivalent class:
  union of: Ethnicity
  union of: Race
  equivalent class: Race or Ethnicity Combined

Pediatric Overall Performance Category
type: Class
subclass of: Physical And Mental Assessment
comment: Reference: POPC/PCPC Reference: Fiser HD, Tilford JM, Roberson PK. Relationship of illness severity and length of stay to functional outcomes in the pediatric intensive care unit. Critical Care Medicine 2000. 28(4):1173-1179.

environmental exposure measurement
type: Class
type: QualityVariable
subclass of: Environmental Exposure

BPA Free Plastic Container
type: Class
type: NodeShape
subclass of: plastic container
subclass of: Class
  complement of: Restriction
    some values from: Bisphenol A
    on property: SIO_000369
comment: A plastic container that does not contain BPA (Bisphenol A).
equivalent class: Class
  intersection of: plastic container
  intersection of: Class
    complement of: Restriction
      some values from: Bisphenol A
      on property: SIO_000369
  equivalent class: BPA Free Plastic Container

2, 2', 4, 4'-tetrahydroxybenzophenone
type: Class
notation: BP2

Atomic Fluorescence Spectroscopy Instrument
type: Class
subclass of: PhysicalInstrument
definition: a type of electromagnetic spectroscopy that analyzes fluorescence from a sample. It involves using a beam of light, usually ultraviolet light, that excites the electrons in molecules of certain compounds and causes them to emit light; typically, but not necessarily, visible light.
was approved by: PER-Jim-McCusker

did not precipitate
type: Class
subclass of: SIO_001167

Nickel
type: Class
subclass of: Metal
notation: Ni
definition: NICKEL is a trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.

Private Insurance or Self Pay
type: Class
type: QualityValue
subclass of: Insurance
notation: 51

Hemolyzed (covers all three levels), lipemic, and icteric
type: Class
subclass of: SIO_001167

brain ischemia
type: Class
subclass of: SIO_010056
subclass of: Stroke, Cerebral Ischemia, or Cerebral infarction

N-Acetyl-S-(2, 2-dichlorovinyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: DCVMA22
editorial note: To Do: align with CHEBI.

Antimony
type: Class
subclass of: Metal
notation: Sb
definition: ANTIMONY is a metallic element that has the atomic symbol Sb, atomic number 51, and atomic weight 121.75. It is used as a metal alloy and as medicinal and poisonous salts. It is toxic and an irritant to the skin and the mucous membranes.

meter per second
type: SIO_000074
notation: m/s

Breakfast
type: Class
type: NodeShape
subclass of: Meal
comment: The first meal of the day (usually in the morning).

Difference of PCPC Scores
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment
subclass of: Difference
subclass of: Restriction
  some values from: Class
    intersection of: Subtrahend
    intersection of: Pediatric Cerebral Performance Category
  on property: SIO_000008
subclass of: Restriction
  some values from: Class
    intersection of: Minuend
    intersection of: Pediatric Cerebral Performance Category
  on property: SIO_000008
comment: The arithemetic difference of two Pediatric Cerebral Performance Category scores.

2, 5-Dichlorophenol
type: Class
subclass of: Environmental Phenol
notation: DCP25
definition: PHYSICAL DESCRIPTION: Prisms (from benzene, petroleum ether) or white crystals. Odor threshold 30 µg/L at 68-72°F; 33 µg/L at 86°F. Taste threshold 0.5 µg/L. (NTP, 1992)

Uses BPA Free Plastic Containers for Food Or Beverage Storage
type: Class
type: NodeShape
subclass of: Uses Plastic Containers for Food Or Beverage Storage
subclass of: Restriction
  some values from: BPA Free Plastic Container
  on property: SIO_000230
comment: The act of using BPA free plastic containers to store food or beverages.

Protein
type: Class
subclass of: Biological Response

Visit
type: Class
subclass of: SIO_000417
definition: The time interval of an encounter between a study subject and a study administrator.

Proton Pump Inhibitor Treatment
type: Class
type: QualityValue
subclass of: Pharmacotherapy
subclass of: Restriction
  some values from: EC 3.6.3.10 (H+/K+-exchanging ATPase) inhibitor
  on property: SIO_000139
subclass of: proton pump inhibitor agent therapy
notation: 27
definition: Proton Pump Inhibitor Treatment as a form of medical therapy.
editorial note: UPDATE: Yes, add the prescription medication, either as an indicator or as a class under Medical Therapy. Whichever works for the ontology. Why isn't this listed under prescription medication? How do you differentiate between medical therapy and prescription medication?

Hemolyzed (covers all three levels) and lipemic
type: Class
subclass of: SIO_001167

N-Acetyl-S-(2, 4-dimethylphenyl)-L-cysteine + N-Acetyl-S-(2, 5-dimethylphenyl)-L-cysteine + N-Acetyl-S-(3, 4-dimethylphenyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: DPMA
editorial note: To Do: align with CHEBI.

Targeted Analyte
type: Class
subclass of: StudyIndicator
subclass of: Analyte
definition: A targeted analyte is one that has been selected by the CHEAR program as a prioritized analyte for CHEAR lab hubs to measure and has been carried over to HHEAR.
was approved by: PER-Jeanette-Stingone

Cesium
type: Class
subclass of: Metal
notation: Cs
definition: A member of the alkali metals. It has an atomic symbol Cs, atomic number 50, and atomic weight 132.91. Cesium has many industrial applications, including the construction of atomic clocks based on its atomic vibrational frequency.

cubic meter per kilogram
type: SIO_000074
notation: m3/kg

Budesonide/formoterol (Symbicort)
type: Class
subclass of: Asthma Controller Medication

Meal
type: Class
type: NodeShape
subclass of: Activity
comment: Any of the occasions for eating food that occur by custom or habit at more or less fixed times.

No Sickle Cell Anemia
type: Class
type: QualityValue
subclass of: Health Outcome
notation: 138

Born Sixth Or Later
type: Class
type: QualityValue
subclass of: Ordinal Position
subclass of: Birth Order
notation: 241
definition: The sixth or later born child

CAUTI or CLABSI or VAP
type: Class
type: QualityValue
subclass of: hospital-acquired infection
notation: 362
equivalent class: Class
  union of: catheterization associated UTI
  union of: Central Line Infection
  union of: ventilator-associated pneumonia
  equivalent class: CAUTI or CLABSI or VAP

Duration of Medical Procedure
type: Class
type: NodeShape
subclass of: Medical History
subclass of: PATO_0001309
subclass of: Restriction
  some values from: SIO_001024
  on property: SIO_000215
comment: The length of time a patient undergoes a medical procedure

Consumes Food Or Beverage Reheated in Plastic
type: Class
type: NodeShape
subclass of: Environmental Exposure
subclass of: Eating or Drinking
subclass of: Restriction
  some values from: Food Or Beverage Product Reheated in a Plastic Container
  on property: SIO_000230
comment: The act of consuming food (or beverages) that have been reheated in a plastic container.

Behavior Rating Inventory of Executive Function - Preschool Version
type: Class
subclass of: Neurocognitive Assessment
definition: Standardized rating scale designed to specifically measure the range of executive function in preschool-aged children

eosinophils per high-power field
type: Class
subclass of: SIO_000794
comment: A histological count of the eosinophils in a high-power microscopic field of view, or 0.158 mm^2 (x400).

Peripheral Blood Mononuclear Cell
type: Class
subclass of: Cell
definition: Any peripheral blood cell having a round nucleus. These cells consist of lymphocytes (T cells, B cells, NK cells) and monocytes, whereas erythrocytes and platelets have no nuclei, and granulocytes (neutrophils, basophils, and eosinophils) have multi-lobed nuclei.

Retinopathy
type: Class
type: QualityValue
subclass of: Phenotype
notation: 129
definition: Any noninflammatory disease of the retina. This nonspecific term is retained here because of its wide use in the literature, but if possible new annotations should indicate the precise type of retinal abnormality.

Digestive System Disorder
type: Class
type: QualityValue
subclass of: Disease
notation: 392

N-Acetyl-S-(1-hydroxymethyl-2-propenyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: MHBMA1
editorial note: To Do: align with CHEBI.

enzyme unit
type: SIO_000074
notation: enzyme unit

cubic meter
type: SIO_000074
notation: m3

Duration of Vasopressor Agent Therapy
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Duration of Medical Procedure
subclass of: Restriction
  some values from: vasopressor agent therapy
  on property: SIO_000215
comment: The length of time a patient undergoes vasopressor agent therapy

First or Second Trimester
type: Class
subclass of: SIO_000417
subclass of: From Conception
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: Conceiving
definition: The time period from pregnancy week 1 through 28 and includes conception.

Score
type: Class
subclass of: SIO_000075

Perfluorobutanesulfonic acid
type: Class
subclass of: PFC
notation: PFBS

Uses Plastic Containers for Food Or Beverage Storage
type: Class
type: NodeShape
subclass of: Environmental Exposure
subclass of: Activity
subclass of: Restriction
  some values from: plastic container
  on property: SIO_000230
comment: The act of using plastic containers to store food or beverages.

Pediatric Cerebral Performance Category
type: Class
subclass of: Physical And Mental Assessment
comment: Reference: POPC/PCPC Reference: Fiser HD, Tilford JM, Roberson PK. Relationship of illness severity and length of stay to functional outcomes in the pediatric intensive care unit. Critical Care Medicine 2000. 28(4):1173-1179.

Atomic Spectroscopy
type: Class
subclass of: Spectroscopy

enzyme-linked immunosorbent assay (ELISA)
type: Class
subclass of: Immunoassay
definition: ELISA is an immunoassay that uses antibodies and color change to identify a substance (Wikipedia)

High Performance Liquid Chromatography
type: Class
subclass of: Chromatography

Previous Smoker
type: Class
type: QualityValue
subclass of: Smoking Status
notation: 78
definition: The quality of having smoked in the past.

N-Acetyl-S-(1-phenyl-2-hydroxyethyl-L-cysteine + N-Acetyl-S-(2-phenyl-2-hydroxyethyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: PHEMA
editorial note: To Do: align with CHEBI.

Trimethylarsine oxide
type: Class
subclass of: Arsenic Species
notation: Trimethylarsine oxide

Pharmacotherapy
type: Class
type: QualityVariable
subclass of: Prescription Medication and Dietary Supplements
subclass of: Medical Therapy Procedure

hematocrit
type: Class
subclass of: SIO_001018

Catheterization
type: Class
subclass of: SIO_001024

Intellectual disability
type: Class
type: NodeShape
subclass of: Neurodevelopmental abnormality
subclass of: Developmental delay or intellectual disability
comment: Subnormal intellectual functioning which originates during the developmental period. Intellectual disability, previously referred to as mental retardation, has been defined as an IQ score below 70. This term should be used for children at least five years old. For younger children, consider the term Global developmental delay (HP:0001263).

Cognitive Task
type: Class
subclass of: Neurocognitive Assessment

spinal cord
type: Class
subclass of: SIO_000004

Phenotype
type: Class
subclass of: Health Outcome

Cis-Chlordane
type: Class
subclass of: Organochlorine Compound
notation: CCHL

Eats Canned Food
type: Class
type: QualityValue
subclass of: Environmental Exposure
subclass of: Eating or Drinking
subclass of: Restriction
  some values from: Canned Food Product
  on property: SIO_000230
comment: The act of eating food that has been packaged in a metal container.
notation: 9
was approved by: PER-Jeanette-Stingone

Ultra Performance Liquid Chromatography - Mass Spectrometer
type: Class
subclass of: Mass Spectrometer
subclass of: Ultra High Performance Liquid Chromatography Instrument
was approved by: PER-Jim-McCusker

Tandem Mass Spectrometer
type: Class
subclass of: Mass Spectrometer
definition: Tandem mass spectrometry, also known as MS/MS or MS2, involves multiple steps of mass spectrometry selection, with some form of fragmentation occurring in between the stages. In a tandem mass spectrometer, ions are formed in the ion source and separated by mass-to-charge ratio in the first stage of mass spectrometry (MS1). Ions of a particular mass-to-charge ratio (precursor ions) are selected and fragment ions (product ions) are created by collision-induced dissociation, ion-molecule reaction, photodissociation, or other process. The resulting ions are then separated and detected in a second stage of mass spectrometry (MS2).
was approved by: PER-Jim-McCusker

microgram per cubic meter
type: SIO_000074
notation: µg/m3

Fluticasone/salmeterol HFA(Advair HFA)
type: Class
subclass of: Asthma Controller Medication

Month Prior and First Month of Pregnancy
type: Class
subclass of: SIO_000417
definition: The time period beginning at the beginning of the month prior to conception and ending at the end of the first month of pregnancy

Interleukin-10
type: Class
subclass of: Protein
notation: IL10
definition: Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.

Leukocyte
type: Class
subclass of: Blood Component
definition: An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.

CASI Controller Treatment Score
type: Class
type: QuantityVariable
subclass of: Asthma Severity Index Composite Score (CASI)

diethyldithiophosphate
type: Class
subclass of: Alkyl Phosphate Pesticide Metabolite
notation: DEDP
editorial note: To Do: align with CHEBI.

hours per day
type: Class
type: NodeShape
subclass of: UO_0000280

Refractometer
type: Class
subclass of: PhysicalInstrument
definition: A laboratory or field device for the measurement of an index of refraction (refractometry). The index of refraction is calculated from Snell's law while for mixtures, the index of refraction can be calculated from the composition of the material using several mixing rules such as the Gladstone–Dale relation and Lorentz–Lorenz equation.
was approved by: PER-Jim-McCusker

Object
type: Class
subclass of: ScienceIndicator

adrenic acid
type: Class
subclass of: Fatty Acid
notation: C224N6

Gestational Age
type: Class
type: QuantityVariable
subclass of: Birth Outcome
subclass of: Age
definition: The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization
was approved by: PER-Jeanette-Stingone

beta-hexachlorocyclohexane
type: Class
subclass of: Organochlorine Compound
notation: BHCH

Esophagus
type: Class
subclass of: SIO_010003

Annual Maximum Concentration
type: Class
type: QuantityVariable
subclass of: SIO_001114
subclass of: Concentration

Childhood Period
type: Class
subclass of: SIO_000417
subclass of: From Birth
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: birthing
definition: The age span ranging from birth to adolescence

Term Birth
type: Class
type: QualityValue
subclass of: Birth Outcome
notation: 97

4, 4'-(hexafluoroisopropylidene)-dephenol
type: Class
notation: BPAF

Early Concerns or High Risk for Autism
type: Class
type: QualityValue
subclass of: SIO_010056
notation: 343

diethylphosphate
type: Class
subclass of: Alkyl Phosphate Pesticide Metabolite
notation: DEP
editorial note: To Do: align with CHEBI.

microsievert
type: SIO_000074
notation: µSv

Annual Income $5,001 to $10,000
type: Class
type: QualityValue
subclass of: Annual Income $14,999 or Less
subclass of: Annual Income $5,001 to $15,000
notation: 204

Trans-Chlordane
type: Class
subclass of: Organochlorine Compound
notation: TCHL

Never takes
type: Class
subclass of: SIO_001289

California
type: QualityValue
notation: 185

watt-hour
type: SIO_000074
notation: Wh

Blood Component
type: Class
subclass of: Bodily Fluid
definition: A derivable component of whole blood.

Red blood cells present
type: Class
subclass of: SIO_001167

all-cis-icosa-8, 11, 14-trienoic acid
type: Class
subclass of: Fatty Acid
notation: C203N6
definition: An icosatrienoic acid having three cis double bonds at positions 8, 11 and 14.

Urine
type: Class
subclass of: Bodily Fluid
definition: Excretion that is the output of a kidney [database_cross_reference: http://en.wikipedia.org/wiki/Urine][database_cross_reference: https://github.com/geneontology/go-ontology/issues/11025]

Respiratory System Findings Original Result
type: Class
subclass of: Thing

Aligent 8800 Triple Quadrupole ICP-MS
type: Class
subclass of: Triple Quadrupole Inductively Coupled Plasma Mass Spectrometer
was approved by: PER-Jim-McCusker

CASI Lung Function Score
type: Class
type: QuantityVariable
subclass of: Asthma Severity Index Composite Score (CASI)

Step
type: Class
subclass of: Non-Biological Relative
definition: A stepfamily is a family where at least one parent has children that are not genetically related to the other spouse or partner. Either one parent may have children from a previous relationship. Children in a stepfamily may live with one biological parent, or they may live with each biological parent for a period of time. In addition, visitation rights mean that children in stepfamilies often have contact with both biological parents, even if they permanently live with only one. A child is referred to as the stepchild, stepdaughter or stepson of their biological parent's new spouse, and that person as the stepparent, stepfather or stepmother of the child. A stepfather is the husband of one's mother, and not one's biological father. A stepmother is the wife of one's father, and not one's biological mother. A step-grandmother is the wife of one's grandfather, and not one's biological grandmother. A step-grandfather is the husband of one's grandmother, and not one's biological grandfather. Similarly, a stepbrother is the son of a stepparent who one is not biologically related to. A stepsister is the daughter of a stepparent to whom one is not biologically related. A step-grandson is the son of a stepson or stepdaughter who one is not biologically related to. A step-granddaughter is the daughter of a stepson or stepdaughter who one is not biologically related. A parent's spouse of the same sex may also count as a stepparent.

Benzophenone-3
type: Class
subclass of: Environmental Phenol
notation: BP3
definition: Oxybenzone is a benzophenone derivative used as a sunscreen agent. Oxybenzone absorbs UVB and UVA II rays, resulting in a photochemical excitation and absorption of energy. Upon return to ground state, the absorbed energy results in emission of longer wavelength radiation and decreased skin penetration of radiation which reduces the risk of DNA damage.
editorial note: Duplicate of OXB?

magnetic flux density unit
type: SIO_000074
notation: MFDU

SpectraMax Plus 384 Microplate Reader
type: Class
subclass of: Microplate Reader
definition: Get absorbance measurements from 190 to 1000 nm quickly for samples in test tubes, cuvettes, and 96- or 384-well microplates. The SpectraMax® Plus 384 Microplate Reader gives you walk-up convenience for both standard spectrophotometer and microplate reader applications on the same instrument. Monochromator wavelength selection saves you the time and trouble of ever having to change out filters. Typical applications for this powerful reader include DNA and RNA quantification, enzyme kinetic assays, and ELISA based assays. When your project is ready for high throughput, take advantage of StakMax® automated microplate handling compatibility for full robotic integration.
was approved by: PER-Jim-McCusker

Annual Mean Concentration
type: Class
type: QualityVariable
subclass of: Mean Concentration

kilogram
type: SIO_000074
notation: kg

Benzophenone
type: Class
subclass of: Targeted Analyte

Fine Motor Developmental Quotient
type: Class
type: QuantityVariable
subclass of: Development Quotient
subclass of: Restriction
  some values from: CAO_03172
  on property: wasDerivedFrom

Reproductive Health
type: Class
subclass of: StudyIndicator
definition: Reproductive Health Indicator Class
was approved by: PER-Jeanette-Stingone

scoliosis
type: Class
subclass of: SIO_010056
subclass of: Scoliosis or Spinal Surgery

6-hydroxychrysene
type: Class
subclass of: PAH
notation: CHRY6

Technical Post Junior College
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: Education
subclass of: Technical School
notation: 93
definition: Attended a Technical Post Junior College
was approved by: PER-Jeanette-Stingone

weber
type: SIO_000074
notation: Wb

Biological Relative
type: Class
subclass of: Relative
definition: Being from the same biological kinship as another person. In that aspect, consanguinity is the quality of being descended from the same ancestor as another person.

Subject
type: Class
subclass of: SIO_000016
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: Study
definition: A living individual about whom a research investigator (whether a professional or a student) obtains data through 1) intervention or interaction with the individual, or 2) identifiable private information
was approved by: PER-Jeanette-Stingone

Vaginal Birth
type: Class
type: QualityValue
subclass of: birthing
subclass of: Pregnancy Characteristic
subclass of: Route Of Delivery
notation: 24
definition: Had a birthing occur via the vagina.
editorial note: Again, can we add a delivery class

meter
type: SIO_000074
notation: m

Adulthood Period
type: Class
subclass of: From Birth
definition: Time period that begins after adolesence and continues until death

CASI Nighttime Asthma Symptoms Score
type: Class
type: QuantityVariable
subclass of: Asthma Severity Index Composite Score (CASI)

Early Learning Developmental Quotient
type: Class
type: QuantityVariable
subclass of: Development Quotient
subclass of: Restriction
  some values from: CAO_01393
  on property: wasDerivedFrom

stroke
type: Class
subclass of: SIO_010056
subclass of: Stroke, Cerebral Ischemia, or Cerebral infarction

Platinum
type: Class
subclass of: Metal
notation: Pt
definition: Platinum. A heavy, soft, whitish metal, resembling tin, atomic number 78, atomic weight 195.09, symbol Pt. (From Dorland, 28th ed) PLATINUM is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as "alutiae".

Replicate Number
type: Class
subclass of: SampleIndicator
definition: Replicate Number

proton pump inhibitor agent therapy
type: Class
type: NodeShape
subclass of: Pharmacotherapy

Abnormal nervous system physiology
type: Class
type: QualityValue
subclass of: SIO_010056
notation: 352

(7Z, 10Z, 13Z, 16Z, 19Z)-docosapentaenoic acid
type: Class
subclass of: Fatty Acid
notation: C225N3
definition: The all-cis-isomer of a C22 polyunsaturated fatty acid having five double bonds in the 7-, 10-, 13-, 16- and 19-positions.

Fluticasone/salmeterol DPI (Advair Diskus)
type: Class
subclass of: Asthma Controller Medication

Adult
type: Class
type: QualityValue
subclass of: Demographic
subclass of: Developmental Quality
notation: 3
definition: Refers to a person above a threshold age.
was approved by: PER-Jeanette-Stingone

Tissue
type: Class
subclass of: Biospecimen

Some High School
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: High School or Less
notation: 87
definition: Education Level of Some High School
was approved by: PER-Jeanette-Stingone

volt-hour
type: SIO_000074
notation: Vh

Adolescent Period
type: Class
subclass of: SIO_000417
subclass of: From Birth
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: birthing
definition: The age span ranging from adolescence to adulthood

Air Pollutant
type: Class
type: QualityVariable
subclass of: Environmental Exposure

Preschool Child Behavior Checklist Externalizing Subscale
type: Class
subclass of: Neurocognitive Assessment
definition: Subscale of preschool CBCL that assesses externalizing behaviors

CASI Daytime Asthma Symptoms Score
type: Class
type: QuantityVariable
subclass of: Asthma Severity Index Composite Score (CASI)

Tin
type: Class
subclass of: Metal
notation: Sn
definition: TIN is a trace element that is required in bone formation. It has the atomic symbol Sn, atomic number 50, and atomic weight 118.71.

Broken Mitest
type: Class
subclass of: SIO_001167

fish
type: Class
subclass of: Thing

Agilent 1100 HPLC
type: Class
subclass of: High-Performance Liquid Chromatography
was approved by: PER-Jim-McCusker

Some Middle School
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: High School or Less
notation: 90
definition: Attended Some Middle School
was approved by: PER-Jeanette-Stingone

CASI Exacerbation Score
type: Class
type: QuantityVariable
subclass of: Asthma Severity Index Composite Score (CASI)

Advanced Graduate Degree
type: Class
type: QualityValue
subclass of: Education
notation: 4
definition: Having earned a pos-baccalaureate degree

tesla
type: SIO_000074
notation: Tesla

Shotgun Lipidomics
type: Class
subclass of: Electrospray Ionization Mass Spectrometry

Preschool Child Behavior Checklist Internalizing Subscale
type: Class
subclass of: Neurocognitive Assessment
definition: Subscale of preschool CBCL that assesses internalizing behaviors

Some College or Technical School
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: Higher Education
subclass of: Education
notation: 203

Blackbody Infrared Radiative Dissociation (BIRD)
type: Class
subclass of: TandemMassSpectrometry

Reheating Food or Beverage in a Plastic Container
type: Class
type: NodeShape
subclass of: food reheating
subclass of: Restriction
  some values from: Class
    intersection of: food product
    intersection of: Restriction
      some values from: plastic container
      on property: SIO_000128
  on property: SIO_000230
comment: Reheating food (including beverages) in a plastic container; the food may have been placed in the plastic container for the purposes of reheating, or it may have been packaged in plastic as a single product unit.

SIO_010048
type: QualityValue
notation: 111

N-Acetyl-S-(2-hydroxy-3-butenyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: MHBMA2
editorial note: To Do: align with CHEBI.

Mexico
type: QualityValue
notation: 183

mild eosinophilic esophagitis
type: Class
subclass of: eosinophilic esophagitis
comment: Eosinophilic esophagitis is mild when a biopsy of the esophagus reveals a count of 15-25 eosinophils per high-power field area, or 0.158 mm^2 (400x).
equivalent class: Restriction
  on property: SIO_001280
  equivalent class: mild eosinophilic esophagitis
  all values from: Class
    intersection of: Esophagus
    intersection of: Restriction
      some values from: Class
        intersection of: eosinophils per high-power field
        intersection of: Restriction
      on property: SIO_000008

cells per microliter
type: SIO_000074
notation: cp/µl

Not Well Controlled Asthma
type: Class
type: QualityValue
subclass of: Health Outcome
subclass of: asthma
subclass of: SIO_001295
notation: 296

4-(methlynitrosamino)-1-(3-pyridyl)-1-butanol
type: Class
subclass of: Tobacco Metabolite
notation: NNAL
editorial note: To Do: align with CHEBI.

Sibling
type: Class
type: QualityValue
subclass of: Relative
subclass of: SIO_000287
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: Restriction
      on property: hasRole
      all values from: Sibling
    intersection of: SIO_000485
notation: 353
definition: One of two or more individuals having one or both parents in common. A male sibling is a brother, and a female sibling is a sister. In most societies throughout the world, siblings often grow up together, thereby facilitating the development of strong emotional bonds. The emotional bond between siblings is often complicated and is influenced by factors such as parental treatment, birth order, personality, and personal experiences outside the family. However, there are cases where siblings grow up in separate homes, in different environments.
was approved by: PER-Jeanette-Stingone

Perfluorodecanoic acid
type: Class
subclass of: PFC
notation: PFDA

Quantity of sample insufficient for repeat analysis
type: Class
subclass of: SIO_001167

Nitrogen Dioxide
type: Class
subclass of: Environmental Exposure

Eats School Breakfast
type: Class
type: NodeShape
subclass of: Eating or Drinking
subclass of: Diet and Nutrition
subclass of: Restriction
  some values from: School Breakfast
  on property: SIO_000230
comment: The act of eating a school prepared breakfast.

monoethyl phthalate (DEP)
type: Class
subclass of: Phthalate
notation: MEP

Cell
type: Class
subclass of: Biospecimen

N-Acetyl-S-(2-hydroxypropyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: HPMA2
editorial note: To Do: align with CHEBI.

Active Smoker
type: Class
type: QualityValue
subclass of: Smoking Status
notation: 2
definition: The quality of actively smoking.
editorial note: How is this different from "smoker'?

Some Elementary School
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: High School or Less
notation: 86
definition: Attended Some Elementary School
was approved by: PER-Jeanette-Stingone

Active Non-Tobacco Smoker
type: Class
type: QualityValue
subclass of: Active Smoker
notation: 1
definition: Active Non-Tobacco Smoker

Male Gender
type: Class
type: QualityValue
subclass of: Gender
notation: 323

Prescription Medication and Dietary Supplements
type: Class
subclass of: StudyIndicator
definition: Prescription Medication and Dietary Supplements are forms of medical treatment.
was approved by: PER-Jeanette-Stingone

Well Controlled Asthma
type: Class
type: QualityValue
subclass of: Health Outcome
subclass of: asthma
subclass of: SIO_001297
notation: 297

Cellular debris present
type: Class
subclass of: SIO_001167

Interleukin-27 subunit alpha
type: Class
subclass of: Protein
notation: IL27

Sandwich ELISA
type: Class
subclass of: enzyme-linked immunosorbent assay (ELISA)
definition: Sandwich ELISAs involve attachment of a capture antibody to a solid phase support. Samples containing known or unknown antigen are then added in a matrix or buffer that will minimize attachment to the solid phase. An enzyme-labeled antibody is then added for detection.

Underweight/Normal
type: Class
type: QualityValue
subclass of: Body Weight Quality
subclass of: Restriction
  some values from: Restriction
    some values from: Class
      intersection of: Body Mass Index
      intersection of: Restriction
        some values from: Datatype
        on property: STATO_0000129
    on property: SIO_000008
  on property: SIO_000011
notation: 100

Underweight
type: Class
type: QualityValue
subclass of: Body Weight Quality
subclass of: Underweight/Normal
subclass of: Restriction
  some values from: Restriction
    some values from: Class
      intersection of: Body Mass Index
      intersection of: Restriction
        some values from: Datatype
        on property: STATO_0000129
    on property: SIO_000008
  on property: SIO_000011
notation: 99
definition: BMI < 18.5

South Central Clinic
type: Class
type: QualityValue
subclass of: Population Group
notation: 273

Drowning
type: Class
subclass of: Activity
subclass of: Drowning or Asphyxia or Hanging
comment: Drowning is a type of suffocation induced by the submersion or immersion of the mouth and nose in a liquid. ... An incident of drowning can also cause further complications for victims due to low body temperature, aspiration of vomit, or acute respiratory distress syndrome (respiratory failure from lung inflammation). (Source: https://en.wikipedia.org/wiki/Drowning)

Expressive Language Developmental Quotient
type: Class
type: QuantityVariable
subclass of: Development Quotient
subclass of: Restriction
  some values from: CAO_03173
  on property: wasDerivedFrom

gestational diabetes
type: Class
type: QualityValue
subclass of: diabetes mellitus
notation: 179

times per two months
type: SIO_000074
type: SIO_000794
notation: times / two months

Interferon lambda-2
type: Class
subclass of: Protein
notation: IL28A

Bisphenol A
type: Class
subclass of: Environmental Phenol
notation: BPA
definition: 4, 4'-isopropylidenediphenol is a white to light brown flakes or powder. Has a weak medicine odor. Sinks in water. (USCG, 1999)

dots per inch
type: SIO_000074
notation: dpi

watt per square meter
type: SIO_000074
notation: W/m2

Bismuth
type: Class
subclass of: Metal
notation: Bi
definition: BISMUTH is a metallic element that has the atomic symbol Bi, atomic number 83 and atomic weight 208.98.

milligram
type: SIO_000074
notation: mg

Magnesium
type: Class
subclass of: Metal
notation: Mg
definition: An element with atomic symbol Mg, atomic number 12, and atomic weight 24.3. Magnesium is an alkaline earth metal and is important to bone structure in human physiology.

Feces
type: Class
subclass of: Biospecimen
definition: Portion of semisolid bodily waste discharged through the anus[MW, modified] [database_cross_reference: http://en.wikipedia.org/wiki/Feces][database_cross_reference: http://www.merriam-webster.com/dictionary/feces]

Anemia
type: Class
type: QualityValue
subclass of: Phenotype
notation: 128
definition: A reduction in erythrocytes volume or hemoglobin concentration.

UBERON_0036255
deprecated: true

Visual Reception Developmental Quotient
type: Class
type: QuantityVariable
subclass of: Development Quotient
subclass of: Restriction
  some values from: CAO_03171
  on property: wasDerivedFrom

Unknown Education Level
type: Class
type: QualityValue
subclass of: Education
notation: 101
definition: Level of Education is not known
was approved by: PER-Jeanette-Stingone

White Hispanic
type: Class
type: QualityValue
subclass of: Hispanic or Latino Ethnicity
subclass of: White
notation: 145
definition: White and Hispanic

Hanging
type: Class
subclass of: Activity
subclass of: Drowning or Asphyxia or Hanging
comment: Hanging is the suspension of a person by a noose or ligature around the neck. ... Hanging is a common method of suicide in which a person applies a ligature to the neck and brings about unconsciousness and then death by suspension or partial suspension. (Source: https://en.wikipedia.org/wiki/Hanging).

8,12-iso-Isoprostane-F2 alpha-VI
type: Class
subclass of: Targeted Analyte
subclass of: isoprostane
notation: F2A12I
definition: An Isoprostane with the CAS # 1445349-99-4

Mean Body Weight
type: Class
type: QuantityVariable
subclass of: SIO_001109
subclass of: Body Weight Quality

millimolal
type: SIO_000074
notation: mmol/kg

parasite count
type: Class
subclass of: Concentration

3, 4-Dihydroxy benzoic acid
type: Class
subclass of: Environmental Phenol
notation: DHB34

gram
type: SIO_000074
notation: g

Cobalt
type: Class
subclass of: Metal
notation: Co
definition: COBALT is a trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.

renal dialysis
type: Class
subclass of: SIO_001024
subclass of: ventilator supporting therapy
subclass of: Home Medical Technology

mono-isononyl phthalate
type: Class
subclass of: Phthalate
notation: mINP

Religion
type: Class
type: QualityVariable
subclass of: Demographic
definition: Religious Belief

Third Trimester
type: Class
subclass of: SIO_000417
subclass of: From Conception
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: Conceiving
definition: From 29 weeks through 40 weeks.
was approved by: PER-Jeanette-Stingone

Communication Developmental Quotient
type: Class
type: QuantityVariable
subclass of: Development Quotient
subclass of: Restriction
  some values from: Vineland Communication Domain
  on property: wasDerivedFrom

Tobacco Cessation Intervention Group
type: Class
type: QualityValue
subclass of: Experimental Group
notation: 202
definition: A group receiving a tobacco cessation intervention that is being tested in a study.

USC Obstetrics-Gynecology
type: Class
type: QualityValue
subclass of: Population Group
notation: 271

Interstitial collagenase
type: Class
subclass of: Protein
notation: MMP1

Quality Control
type: Class
subclass of: Analyte
definition: The value contains quality control data

Cardiovascular disease - congenital
type: Class
type: QualityValue
subclass of: arteriosclerotic cardiovascular disease
notation: 389

nanogram
type: SIO_000074
notation: ng

p-Xylene*
type: Class
subclass of: Volatile Organic Compound
notation: PXY
definition: P-xylene is a colorless watery liquid with a sweet odor. Less dense than water. Insoluble in water. Irritating vapor. Freezing point is 56°F. (USCG, 1999)

pixels per inch
type: SIO_000074
notation: p/in

Limit of Quantitation
type: Class
subclass of: Concentration
definition: The Limit of Quantitation is the lowest concentration at which the analyte can not only be reliably detected but at which some predefined goals for bias and imprecision are met. The LoQ may be equivalent to the LoD or it could be at a much higher concentration. (Source: Limit of Blank, Limit of Detection and Limit of Quantitation, David A Armbruster and Terry Pry https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556583/)

Route Of Delivery
type: Class
type: QualityVariable
subclass of: Delivery Characteristics

extracorporeal membrane oxygenation
type: Class
subclass of: SIO_001024
subclass of: ventilator supporting therapy

Total nicotine
type: Class
subclass of: Tobacco Metabolite
notation: TNIC
editorial note: Duplicate of NIC?

Replicate
type: Class
subclass of: Analyte
definition: The value contains data for a repeat of the study sample

Community Recruit
type: Class
type: QualityValue
subclass of: Population Group
notation: 272

Receptive Language Developmental Quotient
type: Class
type: QuantityVariable
subclass of: Development Quotient
subclass of: Restriction
  some values from: CAO_03174
  on property: wasDerivedFrom

bronchial disease
type: Class
subclass of: Disease

food product
type: Class
type: NodeShape
subclass of: SIO_010363

Congenital anomaly or chromosomal defect
type: Class
type: QualityValue
subclass of: Disease
notation: 390
equivalent class: Class
  union of: chromosomal aberration
  union of: Congenital Abnormality
  equivalent class: Congenital anomaly or chromosomal defect

einstein per square meter per second
type: SIO_000074
notation: einstein/sm2

Aspergillus
type: Class
subclass of: Thing

micron pixel
type: SIO_000074
notation: µm pixel

microgram
type: SIO_000074
notation: µg

lung disease
type: Class
subclass of: Disease

Placenta
type: Class
subclass of: Tissue
subclass of: Pregnancy Sample
definition: Organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin[GO]. The fetal portion of the placenta is known as the villous chorion. The maternal portion is known as the decidua basalis. The two portions are held together by anchoring villi that are anchored to the decidua basalis by the cytotrophoblastic shell. [database_cross_reference: http://en.wikipedia.org/wiki/Placenta][database_cross_reference: http://www.med.umich.edu/lrc/coursepages/m1/embryology/embryo/06placenta.htm]

Summer
type: Class
type: QualityValue
subclass of: Season
notation: 212

3-methipurc acd, 4-methipurc acd(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOC34M
editorial note: To Do: align with CHEBI.

Quadrapole Time-of-Flight Liquid Chromotography-Mass Spectrometry
type: Class
subclass of: Liquid Chromotography-Mass Spectrometery

Childhood
type: Class
type: QualityValue
subclass of: Demographic
subclass of: Developmental Quality
notation: 11
definition: A time period that begins at the beginning of the human embryonic stage and continues until the end of adolescence.
was approved by: PER-Jeanette-Stingone

Stress
type: Class
type: QualityValue
subclass of: Stress Frequency
notation: 92
definition: Whether or not a person gets stressed.
was approved by: PER-Jeanette-Stingone

Birthplace
type: Class
type: QualityVariable
subclass of: Demographic
subclass of: Location
definition: The place where a person was born.

Lithium
type: Class
subclass of: Metal
notation: Li
definition: An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER.

Childhood Asthma Control Test Score
type: Class
type: QuantityVariable
subclass of: Score
definition: The Childhood Asthma Control Test is a standardized rating scale developed by Nathan et al in 2004, which is used to identify patients from 4 to 11 years old with poorly controlled asthma. This questionnaire contains seven items, four to be answered with the child patient and three to be answered by the child patient's guardian and the score is computed by summing the responses to the seven items. The CACT Score range is from 0 to 27, where a higher number indicates a better level of asthma control.

LAC + USC Med Center
type: Class
type: QualityValue
subclass of: Population Group
notation: 269

Socialization Developmental Quotient
type: Class
type: QuantityVariable
subclass of: Development Quotient
subclass of: Restriction
  some values from: Vineland Socialization Domain
  on property: wasDerivedFrom

base pair
type: SIO_000074
notation: bp

Antimalarial
type: Class
type: QualityValue
subclass of: Medication
notation: 120
definition: A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human.

femtogram
type: SIO_000074
notation: fg

Pregnancy Characteristic
type: Class
subclass of: StudyIndicator
definition: Pregnancy Characteristic Indicator Class
was approved by: PER-Jeanette-Stingone

SIO_000784
type: QualityValue
notation: 109

vegetative amoebae
type: Class
type: NodeShape
subclass of: SIO_010376

First Year of the Common Era
type: NamedIndividual

Fall
type: Class
type: QualityValue
subclass of: Season
notation: 213

Granulocyte-macrophage colony-stimulating factor
type: Class
subclass of: Protein
notation: GMCSF

3-phenoxybenzoic acid
type: Class
subclass of: Alkyl Phosphate Pesticide Metabolite
notation: PBA
editorial note: To Do: align with CHEBI.

Non-ecigarette user
type: Class
type: QualityValue
subclass of: Smoking Status
notation: 199
definition: Doesn't use e-cigarettes.

Reichert AR200 Handheld Digital Refractometer
type: Class
subclass of: Refractometer
definition: Lightweight digital refractometer designed for the food, beverage, agricultural, industrial-fluid, chemical, petrochemical, pharmaceutical, medical, and plastic industries.
was approved by: PER-Jim-McCusker

Motor Skills Developmental Quotient
type: Class
type: QuantityVariable
subclass of: Development Quotient
subclass of: Restriction
  some values from: Vineland Motor Skills Domain
  on property: wasDerivedFrom

Room
type: Class
type: QualityValue
subclass of: Human Dwelling
notation: 249

Technical School
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: Education
notation: 96
definition: Attended a Technical School.
was approved by: PER-Jeanette-Stingone

Cardiovascular disease - acquired
type: Class
type: QualityValue
subclass of: arteriosclerotic cardiovascular disease
notation: 388

Eisner Health
type: Class
type: QualityValue
subclass of: Population Group
notation: 270

mass-to-charge ratio
type: SIO_000074
notation: Th

picogram
type: SIO_000074
notation: pg

watt per steradian per square meter
type: SIO_000074
notation: W/sr/m2

pixels per millimeter
type: SIO_000074
notation: p/mm

Predominantly fibrous material
type: Class
subclass of: SIO_001167

pascal
type: SIO_000074
notation: Pa

9-hydroxyfluorene
type: Class
subclass of: PAH
notation: FLUO9

Theophylline
type: Class
subclass of: Asthma Controller Medication

food reheating
type: Class
type: NodeShape
subclass of: food transformation process
comment: A process to bring an already fully cooked product to serving temperature.

Winter
type: Class
type: QualityValue
subclass of: Season
notation: 210

PCB101
type: Class
subclass of: Polychlorobiphenyl
notation: PCB101

Mirex
type: Class
subclass of: Organochlorine Compound
notation: MIREX

PCB138
type: Class
subclass of: Polychlorobiphenyl
notation: PCB138

endotoxin unit per cubic meter
type: SIO_000074
notation: EU/m3

3, 5, 6-trichloro-2-pyridinol
type: Class
subclass of: Alkyl Phosphate Pesticide Metabolite
notation: TCP
editorial note: To Do: align with CHEBI.

Pregnancy Complication
type: Class
type: QualityValue
subclass of: Pregnancy Characteristic
notation: 75

microsecond
type: SIO_000074
notation: µs

Second Trimester
type: Class
subclass of: SIO_000417
subclass of: From Conception
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: Conceiving
definition: From week 13 through 28. Around the middle of the second trimester, movement of the fetus may be felt. At 28 weeks, more than 90% of babies can survive outside of the uterus if provided with high-quality medical care.
was approved by: PER-Jeanette-Stingone

mono-methyl phthalate
type: Class
subclass of: Phthalate
notation: mMP

All Los Angeles RCs plus Orange, San Diego, Tri-counties, and Inland
type: Class
type: QualityValue
subclass of: Population Group
notation: 340

Study Followup
type: Class
subclass of: SIO_000417
definition: A point in a study where data is gathered after the initial baseline.

mebibyte
type: SIO_000074
notation: MiB

gigabyte
type: SIO_000074
notation: GB

Atopy
type: Class
subclass of: Health Outcome
notation: 361

Fever
type: Class
type: QualityValue
subclass of: Phenotype
notation: 123
definition: Elevated body temperature due to failed thermoregulation.

Spring
type: Class
type: QualityValue
subclass of: Season
notation: 211

Asthma Control Test Score
type: Class
type: QuantityVariable
subclass of: Score
definition: The Asthma Control Test is a standardized rating scale developed by Nathan et al in 2004, which is used to identify patients 12 years or older with poorly controlled asthma. This questionnaire contains five items and the score is computed by summing the responses to the five items. The ACT Score range is from 0 to 25, where a higher number indicates a better level of asthma control.

3-Methylhippuric acid + 4-Methylhippuric acid
type: Class
subclass of: Volatile Organic Compound
notation: MHA34
editorial note: To Do: align with CHEBI.

Preterm Birth
type: Class
type: QualityValue
subclass of: Birth Outcome
notation: 88
definition: Preterm birth, also known as premature birth, is the birth of a baby at fewer than 37 weeks gestational age.
was approved by: PER-Jim-McCusker

Birth Year
type: Class
type: QualityValue
subclass of: SIO_000428
notation: 198
definition: The year in which a person was born.

millisecond
type: SIO_000074
notation: ms

Spontaneous Caesarian Section
type: Class
type: QualityValue
subclass of: Caesarian Section
notation: 22
definition: Had a spontaneous caesarian section
was approved by: PER-Jeanette-Stingone

Household Income
type: Class
type: QuantityVariable
subclass of: SIO_000052
subclass of: Socioeconomic Status
definition: A demographic parameter indicating the amount of earnings made by a family.
was approved by: PER-Jeanette-Stingone

wheezing or tightness in the chest or cough
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment
subclass of: Phenotypic abnormality
equivalent class: Class
  union of: Chest tightness
  union of: Cough
  union of: Wheezing
  equivalent class: wheezing or tightness in the chest or cough

mono-pentyl phthalate
type: Class
subclass of: Phthalate
notation: mPeP

Daily Living Skills Developmental Quotient
type: Class
type: QuantityVariable
subclass of: Development Quotient
subclass of: Restriction
  some values from: Vineland Daily Living Skills Domain
  on property: wasDerivedFrom

joule
type: SIO_000074
notation: J

kibibyte
type: SIO_000074
notation: KiB

degree Celsius
type: SIO_000074
notation: C

Eczema
type: Class
type: QualityValue
subclass of: Inflammatory abnormality of the skin
comment: Eczema has several forms including atopic dermatitis, contact dermatitis, dyshidrotic eczema, nummular eczema, seborrheic dermatitis, and stasis dermatitis. Eczema is a form of dermatitis. The term eczema is broadly applied to a range of persistent skin conditions and can be related to a number of underlying conditions. Manifestations of eczema can include dryness and recurring skin rashes with redness, skin edema, itching and dryness, crusting, flaking, blistering, cracking, oozing, or bleeding.
notation: 425

Reactive Airway Disease
type: Class
type: QualityValue
subclass of: Non-Neoplastic Lung Disorder
notation: 186
definition: Coughing, wheezing, or shortness of breath that is triggered by allergens, infection, or other irritants. [def-source: NCI]

gigabasepair
type: SIO_000074
notation: Gb

Nicotine
type: Class
subclass of: Tobacco Metabolite
notation: NIC
definition: Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.

juvenile rheumatoid arthritis
type: Class
subclass of: Disease

Flunisolide HFA (Aerospan)
type: Class
subclass of: Asthma Controller Medication

Ethnicity
type: Class
type: QualityVariable
subclass of: Demographic
subclass of: SIO_000475
subclass of: Race or Ethnicity Combined
was approved by: PER-Jeanette-Stingone

Born Fourth
type: Class
type: QualityValue
subclass of: Birth Order
subclass of: Fourth
notation: 239
definition: The fourth born child

Chest Tube Placement
type: Class
subclass of: Medical History
subclass of: SIO_001024
subclass of: Restriction
  some values from: Chest Tube
  on property: SIO_000139

Duration of Hospital Admission
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Duration of Healthcare Facility Admission
subclass of: Restriction
  some values from: Hospital Admission
  on property: SIO_000215
comment: The length of time a patient is admitted into a hospital

Overweight BMI
type: Class
type: QualityValue
subclass of: Health Outcome
subclass of: Body Mass Index
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001114
    intersection of: Restriction
      on property: SIO_000300
      has value: 29.0
  on property: SIO_000216
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 25.0
  on property: SIO_000216
subclass of: Restriction
  on property: SIO_000221
  has value: kilogram per square meter

4, 4'-(1-phenylethylidene)bisphenol
type: Class
notation: BPAP

Healthcare Access
type: Class
subclass of: StudyIndicator
definition: Healthcare Access

Tellurium
type: Class
subclass of: Metal
notation: Te
definition: Tellurium. An element that is a member of the chalcogen family. TELLURIUM has the atomic symbol Te, atomic number 52, and atomic weight 127.60. It has been used as a coloring agent and in the manufacture of electrical equipment. Exposure may cause nausea, vomiting, and CNS depression.

Central Line Infection
type: Class
subclass of: hospital-acquired infection
subclass of: Restriction
  some values from: central venous cannula insertion
  on property: SIO_001157
subclass of: CAUTI or CLABSI or VAP

PFC
type: Class
subclass of: Targeted Analyte

Polybrominated Diphenyl Ether
type: Class
subclass of: Targeted Analyte

degree Fahrenheit
type: SIO_000074
notation: F

molar
type: SIO_000074
notation: M

Obese BMI
type: Class
type: QualityValue
subclass of: Health Outcome
subclass of: Body Mass Index
subclass of: Restriction
  on property: SIO_000221
  has value: kilogram per square meter
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 29.0
  on property: SIO_000216

Age
type: Class
type: QuantityVariable
subclass of: Demographic

catheterization associated UTI
type: Class
subclass of: hospital-acquired infection
subclass of: CAUTI or CLABSI or VAP
subclass of: Restriction
  some values from: Catheterization
  on property: SIO_001157
subclass of: urinary tract infection

injury
type: Class
type: QualityValue
subclass of: SIO_000475
notation: 406

Born Fifth
type: Class
type: QualityValue
subclass of: Fifth
subclass of: Birth Order
notation: 240
definition: The fifth born child

Duration of Pediatric ICU Admission
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Duration of Healthcare Facility Admission
subclass of: Restriction
  some values from: Pediatric ICU Admission
  on property: SIO_000215
comment: The length of time a patient is admitted into a pediatric intensive care unit

1-hydroxychrysene
type: Class
subclass of: PAH
notation: CHRY1

mono-isobutyl phthalate (DiBP)
type: Class
subclass of: Phthalate
notation: MiBP

HUC sample having discrepancy between fluorometer results and semi quantative Albustix test results
type: Class
subclass of: SIO_001167

leukotriene E4
type: Class
subclass of: Biological Response

Immunocompromised
type: Class
type: QualityValue
subclass of: immune response
notation: 374

Parous
type: Class
type: QualityValue
subclass of: Parity
notation: 73

4-nitrophenol
notation: PNP

SCD Genotype
type: Class
subclass of: Genotype

Quotient
type: Class
subclass of: SIO_000075

Non-White Non-Hispanic
type: Class
type: QualityValue
subclass of: Non-White
subclass of: Non-Hispanic Ethnicity
notation: 326

Born Second
type: Class
type: QualityValue
subclass of: Birth Order
subclass of: Second
notation: 237
definition: The second born child

Neurological Vascular Malformation
type: Class
type: QualityValue
subclass of: vascular malformation
subclass of: Neurologic
comment: Vascular malformations within the central nervous system
notation: 411
editorial note: Additional research I did suggests this CNS vascular malformations includes AVMs, capillary telangiectasias, cavernous malformations, dural arteriovenous fistulas, venous malformations.

Very turbid
type: Class
subclass of: SIO_001167

Uses Antibiotics
type: Class
type: QualityValue
subclass of: Pharmacotherapy
subclass of: Restriction
  some values from: CHEBI_33281
  on property: SIO_000139
notation: 379
definition: Had a form of treatment which uses antibiotics.

Pediatric ICU Admission
type: Class
type: NodeShape
subclass of: ICU Admission
subclass of: Restriction
  some values from: Pediatric Intensive Care Unit
  on property: SIO_000061
comment: The admission into a pediatric ICU unit.

Hemolyzed (covers all three levels) and debris present
type: Class
subclass of: SIO_001167

Budesonide nebulized (Pulmicort)
type: Class
subclass of: Asthma Controller Medication

liter per kilogram
type: SIO_000074
notation: l/kg

micromolar
type: SIO_000074
notation: µM

Nulliparous
type: Class
type: QualityValue
subclass of: Parity
notation: 62

count per molar second
type: SIO_000074
notation: 1/Ms

Interleukin-33
type: Class
subclass of: Protein
notation: IL33

8-iso Prostaglandin F2 alpha
type: Class
subclass of: Targeted Analyte
notation: F2A8IP

Owns Home
type: Class
type: QualityValue
subclass of: Home Ownership
notation: 147
definition: This person owns the home they live in.

Human Dwelling
type: Class
type: QualityVariable
subclass of: Human Dwelling

Duration of Healthcare Facility Admission
type: Class
type: QuantityVariable
type: NodeShape
subclass of: Healthcare Access
subclass of: PATO_0001309
subclass of: SIO_000070
subclass of: Restriction
  some values from: Healthcare Facility Admission
  on property: SIO_000215
comment: The duration of time a patient is admitted into a healthcare facility

Race
type: Class
type: QualityVariable
subclass of: Demographic
subclass of: SIO_000475
subclass of: Race or Ethnicity Combined
was approved by: PER-Jeanette-Stingone

Healthy BMI
type: Class
type: QualityValue
subclass of: Health Outcome
subclass of: Body Mass Index
subclass of: Restriction
  on property: SIO_000221
  has value: kilogram per square meter
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 0.0
  on property: SIO_000216
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001114
    intersection of: Restriction
      on property: SIO_000300
      has value: 25.0
  on property: SIO_000216

Born Third
type: Class
type: QualityValue
subclass of: Birth Order
subclass of: Third
notation: 238
definition: The third born child

Value less than LOD
type: Class
subclass of: SIO_001167

ICU Admission Requiring Tracheostomy
type: Class
type: QualityValue
subclass of: ICU Admission By Tracheostomy Status
subclass of: Restriction
  some values from: tracheostomy
  on property: SIO_000250
comment: An ICU Admission of a patient that requires a tracheostomy immediately upon admission.
notation: 377
equivalent class: Class
  intersection of: ICU Admission
  intersection of: Restriction
    some values from: tracheostomy
    on property: SIO_000250
  equivalent class: ICU Admission Requiring Tracheostomy

Hemolyzed (covers all three levels) and contaminated
type: Class
subclass of: SIO_001167

2, 3, 4, 6-Tetrachlorophenol
type: Class
subclass of: Environmental Phenol
notation: TeCP2346
definition: PHYSICAL DESCRIPTION: Brown flakes or beige solid. Strong odor. (NTP, 1992)

Other Material Finish
type: Class
type: QualityValue
subclass of: Floor Type
notation: 70
definition: Flooring is made from another unspecified material.
was approved by: PER-Jeanette-Stingone

Metalloproteinase inhibitor 2
type: Class
subclass of: Protein
notation: TIMP2

count per nanomolar second
type: SIO_000074
notation: 1/nMs

millimolar
type: SIO_000074
notation: mM

Abnormality of the respiratory system
type: Class
type: QualityVariable
subclass of: Health Outcome

Tumor necrosis factor
label: TNF-alpha
type: Class
subclass of: Protein
notation: TNFA
definition: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918).

Asthma Controller Use
type: Class
type: QualityVariable
subclass of: Prescription Medication and Dietary Supplements
subclass of: SIO_001398
subclass of: Pharmacotherapy
subclass of: Asthma Controller Medication Prescription
subclass of: Restriction
  some values from: SIO_000393
  on property: SIO_000291
subclass of: Restriction
  some values from: Asthma Controller Medication
  on property: SIO_000230
definition: A subclass of medical intervention that characterizes a patient's experience with using an asthma controller medication. Subclasses detail the level to which a patient has used such a medication to control their asthma symptoms, from never used to always uses.
equivalent class:
  union of: Has taken asthma control medications
  union of: Never takes asthma control medications
  equivalent class: Asthma Controller Use

Toxin Ingestion
type: Class
subclass of: Drug or Toxin Ingestion
subclass of: ingestion
subclass of: Restriction
  some values from: toxin
  on property: SIO_000139

Garage
type: Class
type: QualityValue
subclass of: Human Dwelling
notation: 235
definition: A building, or part of a building primarily used for housing a motor vehicle or vehicles.

Gas Chromatography
type: Class
subclass of: Chromatography

Hospital Admission By Admission Source
type: Class
type: QualityVariable
type: NodeShape
subclass of: Healthcare Access
subclass of: Hospital Admission
comment: A subclass of Hospital Admission; this class is used to differentiate between admissions that originate from the ER department of the study hospital versus those that do not.

Post-Birth 1 Minute
type: Class
subclass of: SIO_000417
definition: One minute after birth of a child

asphyxia
type: Class
subclass of: Phenotypic abnormality
subclass of: Drowning or Asphyxia or Hanging

Interleukin-31
type: Class
subclass of: Protein
notation: IL31

Polygamous
type: Class
type: QualityValue
subclass of: Marital Status
notation: 45
definition: A type of living arrangement or mating system in which at least one member of a relationship has more than one mate.

count per nanomolar
type: SIO_000074
notation: 1/nM

picomolar
type: SIO_000074
notation: pM

microliter per kilogram
type: SIO_000074
notation: µl/kg

Fluticasone propionate HFA (Flovent HFA)
type: Class
subclass of: Asthma Controller Medication

1-hydroxynaphthalene
type: Class
subclass of: PAH
notation: NAP1

Lymphotoxin-alpha
type: Class
subclass of: Protein
notation: TNFB

Drug or Toxin Ingestion
type: Class
type: QualityValue
subclass of: ingestion
notation: 394
equivalent class: Class
  union of: Drug Ingestion
  union of: Toxin Ingestion
  equivalent class: Drug or Toxin Ingestion

Post-Birth 5 Minutes
type: Class
subclass of: SIO_000417
definition: Five minutes after birth of a child

Uses Muscle Relaxants
type: Class
type: QualityValue
subclass of: Pharmacotherapy
subclass of: Restriction
  some values from: CHEBI_51371
  on property: SIO_000139
definition: Had a form of treatment which uses muscle relaxants.

Upper Respiratory Tract Infection
type: Class
type: QualityVariable
subclass of: Health Outcome
subclass of: infection

Born First
type: Class
type: QualityValue
subclass of: Birth Order
subclass of: First
notation: 236
definition: The first born child

Hospital Admission Not From Study Emergency Department
type: Class
type: QualityValue
type: NodeShape
subclass of: Hospital Admission By Admission Source
comment: An admission into a hospital where a clinical study is being conducted, and the subject was not previously in the study hospital's emergency department.
notation: 436
disjoint with: Hospital Admission From Study Emergency Department

Paraben
type: Class
subclass of: Targeted Analyte

nanomolar
type: SIO_000074
notation: nM

milliliter per kilogram
type: SIO_000074
notation: ml/kg

Non-smoker
type: Class
type: QualityValue
subclass of: Smoking Status
notation: 59
definition: Doesn't smoke cigarettes.

nanosecond
type: SIO_000074
notation: ns

Unplanned Caesarian Section
type: Class
type: QualityValue
subclass of: Caesarian Section
notation: 23
definition: Had an unplanned caesarian section.
was approved by: PER-Jeanette-Stingone

Mean Height
type: Class
type: QuantityVariable
subclass of: Height
subclass of: SIO_001109

Butyl paraben
type: Class
subclass of: Paraben
notation: BuPB
definition: Butylparaben is a Standardized Chemical Allergen. The physiologic effect of butylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity. The chemical classification of butylparaben is Allergens.

Seasonal Population Group
type: Class
type: QualityVariable
subclass of: Population Group
definition: A Population Group organized by which season of the year the subjects were tested or studied.

Non-White Hispanic
type: Class
type: QualityValue
subclass of: Non-White
subclass of: Hispanic or Latino Ethnicity
notation: 146
definition: Non-White and Hispanic

Greater than 99th percentile
type: Class
subclass of: SIO_001167

Drowning or Asphyxia or Hanging
type: Class
type: QualityValue
subclass of: Activity
notation: 393
equivalent class: Class
  union of: Drowning
  union of: Hanging
  union of: asphyxia
  equivalent class: Drowning or Asphyxia or Hanging

Doctorate Degree
type: Class
type: QualityValue
subclass of: Some Postgraduate
subclass of: Higher Education
notation: 144
definition: The Doctor's Degree is the highest award a student can earn for graduate study. The doctor's degree classification includes such degrees in any field.

mono-hexyl phthalate
type: Class
subclass of: Phthalate
notation: mHxP

Required Home Medical Technology Prior to Hospital Admission
type: Class
type: QualityValue
type: NodeShape
subclass of: Hospital Admission By Prior Home Medical Technology Use
subclass of: Restriction
  some values from: Home Medical Technology
  on property: SIO_000249
comment: Denotes hospital admissions in which the patient required the use of home medical technology prior to admission.
notation: 433
equivalent class: Class
  intersection of: Hospital Admission
  intersection of: Restriction
    some values from: Home Medical Technology
    on property: SIO_000249
  equivalent class: Required Home Medical Technology Prior to Hospital Admission
disjoint with: Did Not Require Home Medical Technology Prior to Hospital Admission

molal
type: SIO_000074
notation: mol/kg

foot candle
type: SIO_000074
notation: ft-c

picometer
type: SIO_000074
notation: pm

Ethylbenzene
type: Class
subclass of: Volatile Organic Compound
notation: EB
definition: Ethylbenzene is mainly used in the manufacture of styrene. Acute (short-term) exposure to ethylbenzene in humans results in respiratory effects, such as throat irritation and chest constriction, irritation of the eyes, and neurological effects such as dizziness. Chronic (long-term) exposure to ethylbenzene by inhalation in humans has shown conflicting results regarding its effects on the blood. Animal studies have reported effects on the blood, liver, and kidneys from chronic inhalation exposure to ethylbenzene. Limited information is available on the carcinogenic effects of ethylbenzene in humans. In a study by the National Toxicology Program (NTP), exposure to ethylbenzene by inhalation resulted in an increased incidence of kidney and testicular tumors in rats, and lung and liver tumors in mice. EPA has classified ethylbenzene as a Group D, not classifiable as to human carcinogenicity.

Allergen
type: Class
subclass of: Thing

vasopressor agent therapy
type: Class
type: QualityVariable
subclass of: Pharmacotherapy

Asthma Controller Medication
type: Class
subclass of: SIO_010039
definition: A class of pharmeceutical drugs that are used to prevent or manage the onset of acute asthma before an attack occurs.

Did Not Require Home Medical Technology Prior to Hospital Admission
type: Class
type: QualityValue
type: NodeShape
subclass of: Hospital Admission By Prior Home Medical Technology Use
subclass of: Class
  complement of: Restriction
    some values from: Home Medical Technology
    on property: SIO_000249
comment: Denotes hospital admissions in which the patient did not require the use of home medical technology prior to admission.
notation: 434
equivalent class: Class
  intersection of: Hospital Admission
  intersection of: Class
    complement of: Restriction
      some values from: Home Medical Technology
      on property: SIO_000249
  equivalent class: Did Not Require Home Medical Technology Prior to Hospital Admission
disjoint with: Required Home Medical Technology Prior to Hospital Admission

Gravimetric Analysis Instrument
type: Class
subclass of: PhysicalInstrument
definition: Gravimetric analysis describes a set of methods used in analytical chemistry for the quantitative determination of an analyte (the ion being analyzed) based on its mass. The principle behind this type of analysis is that once an ion's mass has been determined as a unique compound, that known measurement can then be used to determine the same analyte's mass in a mixture, as long as the relative quantities of the other constituents are known.
was approved by: PER-Jim-McCusker

Tetrachloroethene
type: Class
subclass of: Volatile Organic Compound
notation: TCE
definition: TETRACHLOROETHYLENE is a chlorinated hydrocarbon used as an industrial solvent and cooling liquid in electrical transformers. It is a potential carcinogen.

4-hydroxychrysene
type: Class
subclass of: PAH
notation: CHRY4

Drug Ingestion
type: Class
subclass of: Drug or Toxin Ingestion
subclass of: ingestion
subclass of: Restriction
  some values from: drug
  on property: SIO_000139

Pregnancy Month 1
type: Class
subclass of: SIO_000417
definition: The first month of pregnancy

11 or More Residence Building
type: Class
type: QualityValue
subclass of: Multi Residence Building
notation: 234
definition: A residential building that contains eleven or more apartments, town houses, condos, or other single family dwelling spaces.

Oxybenzone
type: Class
subclass of: Volatile Organic Compound
notation: OXB
definition: Oxybenzone is a benzophenone derivative used as a sunscreen agent. Oxybenzone absorbs UVB and UVA II rays, resulting in a photochemical excitation and absorption of energy. Upon return to ground state, the absorbed energy results in emission of longer wavelength radiation and decreased skin penetration of radiation which reduces the risk of DNA damage.

count per molar
type: SIO_000074
notation: 1/M

Gold
type: Class
subclass of: Metal
notation: Au
definition: GOLD is a yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.

phthalic acid
type: Class
subclass of: Phthalate
notation: PA
definition: PHYSICAL DESCRIPTION: White crystals or fine white powder. (NTP, 1992)

Sneezing, Runny Nose, or Congestion
type: Class
type: NodeShape
subclass of: SIO_010056
notation: 428
equivalent class: Class
  union of: Sneeze
  union of: Rhinorrhea
  union of: Nasal congestion
  equivalent class: Sneezing, Runny Nose, or Congestion

Oxygen Treatment
type: Class
subclass of: SIO_001398
subclass of: Medical History
subclass of: Home Medical Technology
subclass of: Restriction
  some values from: SIO_011007
  on property: SIO_000139
comment: A medical intervention in which a patient is treated with oxygen.

DNA
type: Class
subclass of: Macromolecule

4-Hydroxybenzoic acid
type: Class
subclass of: Environmental Phenol
notation: HB4

psychiatric disorder
type: Class
subclass of: Comorbidity Disease

Non-Hispanic Ethnicity
type: Class
type: QualityValue
subclass of: Ethnicity
notation: 58
definition: Non-Hispanic Ethnicity
was approved by: PER-Jeanette-Stingone

SIO_010058
type: QualityValue
notation: 131

A Sample has a Pairing
type: Class
subclass of: SIO_001049
definition: Refers to having paired samples.
was approved by: PER-Jeanette-Stingone
editorial note: This actually should be a process. What should we do?

N-Ace-S-(dimethylphenyl)-L-Cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCDPM
editorial note: To Do: align with CHEBI.

Urine grossly hematuric
type: Class
subclass of: SIO_001167

Non-Spontaneous Preterm Birth
type: Class
type: QualityValue
subclass of: Preterm Birth
notation: 60

Eats Fried Fish
type: Class
type: QualityValue
subclass of: Eating or Drinking
subclass of: Restriction
  some values from: FOODON_03310717
  on property: SIO_000369
notation: 229
definition: The attribute of eating fried fish.

Head
type: Class
subclass of: SIO_010046

Food Product Packaged in Plastic
type: Class
type: NodeShape
subclass of: food product
subclass of: Restriction
  some values from: plastic container
  on property: SIO_000128
equivalent class: Class
equivalent class: Class
  intersection of: food product
  intersection of: Restriction
    some values from: plastic container
    on property: SIO_000128
  equivalent class: Food Product Packaged in Plastic

2-hydroxyfluorene
type: Class
subclass of: PAH
notation: FLUO2

megabasepair
type: SIO_000074
notation: Mb

SIO_010059
type: QualityValue
notation: 132

thousand parts per microgram
type: SIO_000074
notation: x103 µL

N-Acel-S-(2, 2-Dichlorvinyl)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOC2DC
editorial note: To Do: align with CHEBI.

Unusually high
type: Class
subclass of: SIO_001167

Eats Shell Fish
type: Class
type: QualityValue
subclass of: Eating or Drinking
subclass of: Restriction
  some values from: FOODON_03411433
  on property: SIO_000369
notation: 230
definition: The attribute of eating shell fish.

Other GI Disease
type: Class
type: QualityValue
subclass of: SIO_010299
subclass of: Health Outcome
notation: 69
editorial note: This is a temp concept that needs addressing

Freeze/Thaw Cycles Count
type: Class
type: QuantityVariable
subclass of: SIO_000794
definition: Number of Freeze/Thaw cycles.
was approved by: PER-Jeanette-Stingone

Fenton Weighted Z-Score
type: Class
type: QuantityVariable
subclass of: Z-Score
subclass of: SIO_001245
subclass of: Birth Outcome
subclass of: Class
  intersection of: SIO_001245
  intersection of: Restriction
    some values from: Birth Weight
    on property: wasDerivedFrom
  intersection of: Restriction
    some values from: Fenton Preterm Growth Chart
    on property: wasDerivedFrom
  intersection of: Restriction
    some values from: Gestational Age at Birth
    on property: wasDerivedFrom
definition: Derived from Birth Weight, Gestational Age, and Child Sex
was approved by: PER-Jeanette-Stingone

alpha-hexachlorocyclohexane
type: Class
subclass of: Organochlorine Compound
notation: AHCH

Styrene
type: Class
subclass of: Volatile Organic Compound
notation: STY
definition: STYRENE is a colorless, toxic liquid with a strong aromatic odor. It is used to make rubbers, polymers and copolymers, and polystyrene plastics.

oleic acid
type: Class
subclass of: Fatty Acid
notation: C181N9
definition: An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry.

Domestic Partnership
type: Class
type: QualityValue
subclass of: Unmarried
notation: 42
definition: Indicates a person who is a member of an unmarried couple, including same sex couples, living together in longstanding relationships, that are registered or unregistered.

ICU Discharge On Oxygen
type: Class
type: QualityValue
subclass of: Restriction
  some values from: Oxygen Treatment
  on property: SIO_000250
subclass of: ICU Discharge By Oxygen Use
comment: An event in which a patient is discharged from an intensive care unit and is given oxygen treatment.
notation: 372
equivalent class: Class
  intersection of: ICU Discharge
  intersection of: Restriction
    some values from: Oxygen Treatment
    on property: SIO_000250
  equivalent class: ICU Discharge On Oxygen
disjoint with: ICU Discharge Not On Oxygen

SIO_001068
type: QualityValue
notation: 135

Mean Circumference
type: Class
type: NodeShape
subclass of: SIO_001109
subclass of: Circumference
comment: The mean value obtained from several measurements of an object's circumference

Propyl paraben
type: Class
subclass of: Paraben
notation: PrPB
definition: Propylparaben is a Standardized Chemical Allergen. The physiologic effect of propylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity. The chemical classification of propylparaben is Allergens.

Arsenocholine
type: Class
subclass of: Arsenic Species
notation: Arsenocholine

Microwave Oven Count
type: Class
type: QuantityVariable
subclass of: Household Appliance Count
definition: Number of machines in the home used to heat up food using microwaves.
was approved by: PER-Jeanette-Stingone
editorial note: Putting a note here, but it applies to all of the appliances. These are used to calculate the SES Index that was reported within one of the pilots. So, there needs to be some connection between these terms.

chronic obstructive pulmonary disease
type: Class
type: QualityValue
subclass of: Comorbidity Disease
notation: 382

Acculturation
type: Class
subclass of: StudyIndicator
definition: Acculturation explains the process of cultural change and psychological change that results following meeting between cultures. This metaclass contains all classes that measure this process.
was approved by: PER-Jeanette-Stingone

N-Ace-S-(3-Hydroxypropyl)-L-Cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCHPM
editorial note: To Do: align with CHEBI.

Value above LOD but below LLOQ
type: Class
subclass of: SIO_001167

Organochlorine Compound
type: Class
subclass of: Targeted Analyte

Eats Fresh Fish
type: Class
type: QualityValue
subclass of: Eating or Drinking
subclass of: Restriction
  some values from: FOODON_03315446
  on property: SIO_000369
notation: 227
definition: The attribute of eating fresh fish.

Arsenous ( III) Acid
type: Class
subclass of: Arsenic Species
notation: Arsenous (III) Acid

Hospital Discharge On Oxygen
type: Class
type: QualityValue
subclass of: Restriction
  some values from: Oxygen Treatment
  on property: SIO_000250
subclass of: Hospital Discharge By Oxygen Use
comment: An event in which a patient is discharged from a hospital and is given oxygen treatment.
notation: 370
equivalent class: Class
  intersection of: Hospital Discharge
  intersection of: Restriction
    some values from: Oxygen Treatment
    on property: SIO_000250
  equivalent class: Hospital Discharge On Oxygen
disjoint with: Hospital Discharge Not On Oxygen

T-Score
type: Class
subclass of: Physical And Mental Assessment
subclass of: Score
definition: A method for converting an individual score into a standard form. While similar to a z-score, t-score is used when the conversion is made without knowledge of the population standard deviation and mean.

Developmental delay or intellectual disability
type: Class
type: QualityValue
subclass of: Neurodevelopmental abnormality
notation: 427
equivalent class: Class
  union of: Intellectual disability
  union of: Neurodevelopmental delay
  equivalent class: Developmental delay or intellectual disability

Abdomen
type: Class
subclass of: SIO_010046

Neighbor
type: Class
type: QualityValue
subclass of: Demographic
subclass of: SIO_000016
subclass of: SIO_000287
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: SIO_000485
notation: 355
definition: A person living near or next door to another person.

Abnormal hemoglobin variant observed
type: Class
subclass of: SIO_001167

Valid measurement, results repeated and confirmed (0, 33)
type: Class
subclass of: SIO_001167

N-Ace-S-(N-methlcarbamoyl)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCAMC
editorial note: To Do: align with CHEBI.

spinal injury
type: Class
type: NodeShape
subclass of: Neurological Issues with Spinal Cord

Multiplex real-time PCR
type: Class
subclass of: Polymerase Chain Reaction

Height
type: Class
type: QuantityVariable
subclass of: Anthropometry
definition: Height
was approved by: PER-Jeanette-Stingone

Eats Canned Fish
type: Class
type: QualityValue
subclass of: Eats Canned Food
subclass of: Restriction
  some values from: FOODON_03302764
  on property: SIO_000369
notation: 228
definition: The attribute of eating canned fish.

Behavioral Experimental Paradigm
type: Class
subclass of: Neurocognitive Assessment

ICU Admission Not Requiring Mechanical Ventilation
type: Class
type: QualityValue
type: NodeShape
subclass of: ICU Admission By Mechanical Ventilation Status
subclass of: Class
  complement of: Restriction
    some values from: invasive mechanical ventilation
    on property: SIO_000250
notation: 438
equivalent class: Class
  intersection of: ICU Admission
  intersection of: Class
    complement of: Restriction
      some values from: invasive mechanical ventilation
      on property: SIO_000250
  equivalent class: ICU Admission Not Requiring Mechanical Ventilation
disjoint with: ICU Admission Requiring Mechanical Ventilation

cerebral infarction
type: Class
subclass of: SIO_010056
subclass of: Stroke, Cerebral Ischemia, or Cerebral infarction

Annual Income $100,000 to $199,999
type: Class
type: QualityValue
subclass of: Annual Income More Than $95,000
notation: 422

Hospital Discharge
type: Class
type: QualityVariable
subclass of: Healthcare Access
subclass of: Medical History
subclass of: Medical Discharge
subclass of: Restriction
  some values from: Hospital Admission
  on property: SIO_000249
comment: An event in which a person is discharged from a hospital.

Torn, perforated screen
type: Class
subclass of: SIO_001167

pre-eclampsia
type: Class
type: QualityValue
subclass of: artery disease
notation: 177

Failed positive control
type: Class
subclass of: SIO_001167

Volatile Organic Compound
type: Class
subclass of: Targeted Analyte

No Anti Malarial Use
type: Class
type: QualityValue
subclass of: Antimalarial Use
subclass of: Prescription Medication and Dietary Supplements
notation: 140

Malarial Retinopathy
type: Class
type: QualityValue
subclass of: Retinopathy
notation: 130
definition: Retinopathy due to malaria.

N-Ace-S-(2-carbamoylethyl)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCAAM
editorial note: To Do: align with CHEBI.

dehydroepiandrosterone sulfate
type: Class
subclass of: Biological Response
subclass of: Metabolite
definition: A steroid sulfate that is the 3-sulfooxy derivative of dehydroepiandrosterone.

Advance Directive
type: Class
type: QualityVariable
subclass of: Medical History
subclass of: SIO_000148

Beryllium
type: Class
subclass of: Metal
notation: Be
definition: Beryllium. An element with the atomic symbol Be, atomic number 4, and atomic weight 9.01218. Short exposure to this element can lead to a type of poisoning known as BERYLLIOSIS.

cyclic peptide
type: Class
subclass of: Biological Response
subclass of: Metabolite
definition: A molecular entity capable of accepting a hydron from a donor (Bronsted acid).

Pathogen Transmission
type: Class
subclass of: Process

ICU Discharge
type: Class
type: QualityVariable
subclass of: Healthcare Access
subclass of: Medical History
subclass of: Restriction
  some values from: ICU Admission
  on property: SIO_000249
subclass of: Medical Discharge
comment: An event in which a person is discharged from an intensive care unit.

Hospital Admission By Prior Home Medical Technology Use
type: Class
type: QualityVariable
type: NodeShape
subclass of: Medical History
subclass of: Hospital Admission
comment: A subclass of Hospital Admission; differentiates hospital admissions by whether or not the patient required home medical technology use prior to admission.

Annual Income More Than $200,000
type: Class
type: QualityValue
subclass of: Annual Income More Than $120,000
notation: 423

Copper
type: Class
subclass of: Metal
notation: Cu
definition: COPPER is a heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.

Torn bag (Mitest intact, capped)
type: Class
subclass of: SIO_001167

all-cis-docosa-4, 7, 10, 13, 16, 19-hexaenoic acid
type: Class
subclass of: Fatty Acid
notation: C226N3
definition: A docosahexaenoic acid having six cis-double bonds at positions 4, 7, 10, 13, 16 and 19.

Failed negative control
type: Class
subclass of: SIO_001167

Neurocognitive Assessment
type: Class
subclass of: Physical And Mental Assessment

Mercury Species
type: Class
subclass of: Targeted Analyte

N-Ace-S-(2-hydroxypropyl)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCHP2
editorial note: To Do: align with CHEBI.

Interleukin-15
type: Class
subclass of: Protein
notation: IL15

Zinc
type: Class
subclass of: Metal
notation: Zn
definition: A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.

Mean Concentration Range > 1000 ng/mL
type: Class
type: QualityValue
subclass of: Mean Concentration
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 1000.0
  on property: SIO_000216
subclass of: Restriction
  on property: SIO_000221
  has value: nanogram per milliliter
notation: 322

Nervous System
type: Class
subclass of: SIO_010003
definition: The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior

Cognitive Entity
type: Class
subclass of: Neurocognitive Assessment

Healthcare Facility Admission
type: Class
subclass of: Activity
subclass of: Restriction
  some values from: Healthcare Facility
  on property: SIO_000061
subclass of: Restriction
  some values from: SIO_000393
  on property: SIO_000132
comment: An event in which a patient is admitted into a healthcare facility.

SIO_010052
type: QualityValue
notation: 110

Methyl Paraben
type: Class
subclass of: Paraben
notation: MePB
definition: Methylparaben is a Standardized Chemical Allergen. The physiologic effect of methylparaben is by means of Increased Histamine Release, and Cell-mediated Immunity. The chemical classification of methylparaben is Allergens.

ICU Admission By Mechanical Ventilation Status
type: Class
type: QualityVariable
type: NodeShape
subclass of: Medical History
subclass of: ICU Admission
comment: A subclass of ICU Admission; it is used to differentiate between when patients require a invasive mechanical ventilation (dialysis, nitric oxide ventilation, or ECMO) during their ICU admission versus when they do not.

microbial phenotype
type: Class
subclass of: SIO_010056

Diet
type: Class
type: QualityVariable
subclass of: Diet and Nutrition
definition: The customary allowance of food and drink taken by a person or an animal from day to day, particularly one especially planned to meet specific requirements of the individual, including or excluding certain items of food; a prescribed course of eating and drinking in which the amount and kind of food, as well as the times at which it is to be taken, are regulated for therapeutic purposes or selected with reference to a particular state of health.

linoleic acid
type: Class
subclass of: Fatty Acid
notation: C182N6
definition: An octadecadienoic acid in which the two double bonds are at positions 9 and 12 and have Z (cis) stereochemistry.

picomoles per milliliter
type: SIO_000074
notation: pmol/ml

Unusual color
type: Class
subclass of: SIO_001167

Fibrin present
type: Class
subclass of: SIO_001167

Liquid Chromatography–Mass Spectrometer
type: Class
subclass of: Liquid Chromatography Instrument
subclass of: Mass Spectrometer
definition: An analytical chemistry technique that combines the physical separation capabilities of liquid chromatography (or HPLC) with the mass analysis capabilities of mass spectrometry (MS). Coupled chromatography - MS systems are popular in chemical analysis because the individual capabilities of each technique are enhanced synergistically. While liquid chromatography separates mixtures with multiple components, mass spectrometry provides structural identity of the individual components with high molecular specificity and detection sensitivity. This tandem technique can be used to analyze biochemical, organic, and inorganic compounds commonly found in complex samples of environmental and biological origin.
was approved by: PER-Jim-McCusker

Clinical Measurement
type: Class
subclass of: Physical And Mental Assessment
definition: A quantitative or qualitative value which is the result of an act of assessing a morphological or physiological state or property in a single individual or sample or a group of individuals or samples, based on direct observation or experimental manipulation.

10^3 cells per microliter
type: SIO_000074
type: SIO_000794
notation: 10^3 cells / µL

drug
type: Class
subclass of: Thing

Forced Expiratory Flow at 25-75 Percent
type: Class
type: QualityVariable
subclass of: CMO_0000094

Medical Discharge
type: Class
subclass of: Activity
comment: An event in which a person is discharged from a medical facility.

ICU Admission Requiring Mechanical Ventilation
type: Class
type: QualityValue
type: NodeShape
subclass of: ICU Admission By Mechanical Ventilation Status
subclass of: Restriction
  some values from: invasive mechanical ventilation
  on property: SIO_000250
notation: 437
equivalent class: Class
  intersection of: ICU Admission
  intersection of: Restriction
    some values from: invasive mechanical ventilation
    on property: SIO_000250
  equivalent class: ICU Admission Requiring Mechanical Ventilation
disjoint with: ICU Admission Not Requiring Mechanical Ventilation

Turbid
type: Class
subclass of: SIO_001167

Fenton Preterm Growth Chart
type: Class
subclass of: SIO_000442
definition: A growth chart adusted for gestational age

Macromolecule
type: Class
subclass of: Biomolecule
definition: A very large molecule, such as protein, commonly created by polymerization of smaller subunits (monomers). They are typically composed of thousands of atoms or more. The most common macromolecules in biochemistry are biopolymers (nucleic acids, proteins, carbohydrates and polyphenols) and large non-polymeric molecules (such as lipids and macrocycles).

8-hydroxy-2'-deoxyguanosine
type: Class
subclass of: Biological Response
subclass of: Biomolecule
definition: Guanosine substituted at the purine 8-position by a hydroxy group. It is used as a biomarker of oxidative DNA damage.

Inpatient Encounter
type: Class
type: QualityValue
subclass of: Destination
notation: 169
definition: A patient encounter where a patient is admitted to a hospital or equivalent facility.

Wheezing
type: Class
subclass of: wheezing or tightness in the chest or cough

Spontaneous Preterm Birth
type: Class
type: QualityValue
subclass of: Preterm Birth
notation: 91

Mercapturic acid of benzene
type: Class
subclass of: PAH
notation: SPMA

2-hydroxyphenanthrene + 3-hydroxyphenanthrene
type: Class
subclass of: Environmental Phenol
notation: PHEN2_PHEN3

Perfume Use
type: Class
type: QualityValue
subclass of: Personal Product Use
notation: 74
was approved by: PER-Jeanette-Stingone

Childhood Baseline
type: Class
subclass of: SIO_000417
subclass of: Study Baseline
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: Childhood Period
definition: A point in a study set to the initial point which occurs during the study subject's childhood period.

tetradecanoic acid
type: Class
subclass of: Fatty Acid
notation: C140
definition: A straight-chain, fourteen-carbon, long-chain saturated fatty acid mostly found in milk fat.

angstrom
type: SIO_000074
notation: Ang

microgram per gram
type: SIO_000074
notation: µg/g

microcurie per milliliter
type: SIO_000074
notation: µcurie/ml

East Bay, San Andreas, and Golden Gate
type: Class
type: QualityValue
subclass of: Population Group
notation: 338

picoliter
type: SIO_000074
notation: pl

isoprostane
type: Class
subclass of: Thing

Personal Product Use
type: Class
subclass of: StudyIndicator
definition: Personal Product Use Indicator Class
was approved by: PER-Jeanette-Stingone

4, 4'-(1, 4-Phenylenediisopropylidene)bisphenol
type: Class
notation: BPP

Medication
type: Class
type: QualityVariable
subclass of: Prescription Medication and Dietary Supplements
notation: 142
definition: A drug product that contains one or more active and/or inactive ingredients; it is intended to treat, prevent or alleviate the symptoms of disease. This term does not refer to the individual ingredients that make up the product.

African American
type: Class
type: QualityValue
subclass of: Race
subclass of: Non-White
notation: 8
definition: A person having origins in any of the Black racial groups of Africa. Terms such as "Haitian" or "Negro" can be used in addition to "Black or African American".
was approved by: PER-Jeanette-Stingone

Mercapturic acids of acrolein and crotonaldehyde
type: Class
subclass of: PAH
notation: AMA

2-thoxothazlidne-4-carbxylic acid(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCTTC
editorial note: To Do: align with CHEBI.

Childhood Followup
type: Class
subclass of: SIO_000417
subclass of: Study Followup
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: Childhood Period
definition: A point in a study that occurs after the initial baseline of the study and occurs during the study subject's childhood period.

Polymerase Chain Reaction
type: Class
subclass of: SIO_001007

nanometer
type: SIO_000074
notation: nm

Valley Mt, Central Valley, and Kern
type: Class
type: QualityValue
subclass of: Population Group
notation: 339

picogram per cubic meter
type: SIO_000074
notation: pg/m3

Repeat Caesarian Section
type: Class
type: QualityValue
subclass of: Caesarian Section
notation: 21
definition: Had Repeat Caesarian Section

nanoliter
type: SIO_000074
notation: nl

megabyte
type: SIO_000074
notation: MB

Partial match
type: Class
subclass of: SIO_001167

Anthropometry
type: Class
subclass of: StudyIndicator
definition: Attributes pertaining to the scientific study of the measurements and proportions of the human body.
was approved by: PER-Jeanette-Stingone

curie per liter
type: SIO_000074
notation: curie/l

EC 3.6.3.10 (H+/K+-exchanging ATPase) inhibitor
type: Class
type: NodeShape
subclass of: drug

Socioeconomic Status Index
type: Class
type: QuantityVariable
subclass of: SIO_000052
subclass of: Socioeconomic Status
definition: A measure of SES.
editorial note: This is a specific index, derived from other variables. So, it should somehow be connected to this variables. Also, we may want to be more specific about the type of index that it is. Perhaps there should be a general SESIndex and then subclasses of specific measures?

High-Performance Liquid Chromatography-Mass Spectrometry
type: Class
subclass of: High-Performance Liquid Chromatography
subclass of: Mass Spectrometer
subclass of: Liquid Chromatography–Mass Spectrometer
definition: Liquid chromatography–mass spectrometry (LC-MS) is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography (or HPLC) with the mass analysis capabilities of mass spectrometry (MS). Coupled chromatography - MS systems are popular in chemical analysis because the individual capabilities of each technique are enhanced synergistically. While liquid chromatography separates mixtures with multiple components, mass spectrometry provides structural identity of the individual components with high molecular specificity and detection sensitivity. This tandem technique can be used to analyze biochemical, organic, and inorganic compounds commonly found in complex samples of environmental and biological origin. Therefore, LC-MS may be applied in a wide range of sectors including biotechnology, environment monitoring, food processing, and pharmaceutical, agrochemical, and cosmetic industries.
was approved by: PER-Jim-McCusker

hertz
type: SIO_000074
notation: Hz

2-4 Residence Building
type: Class
type: QualityValue
subclass of: Multi Residence Building
notation: 232
definition: A residential building that contains between two and four apartments, town houses, condos, or other single family dwelling spaces.

Monthly Income $3,751 to $4,166
type: Class
type: QualityValue
subclass of: Household Income
notation: 293

2-Thioxothiazolidine-4-carboxylic acid
type: Class
subclass of: Volatile Organic Compound
notation: TTCA
editorial note: To Do: align with CHEBI.

Caregiver
type: Class
subclass of: Demographic
subclass of: SIO_000016
definition: a paid or unpaid and without formal training member of a person's social network who helps them with activities of daily living. Caregiving is most commonly used to address impairments related to old age, disability, a disease, or a mental disorder.

Interleukin-25
type: Class
subclass of: Protein
notation: IL17EIL25

Physical And Mental Assessment
type: Class
subclass of: StudyIndicator
definition: Physical and Mental Assessments Indicator Class
was approved by: PER-Jeanette-Stingone

Lead
type: Class
subclass of: Metal
notation: Pb
definition: LEAD is a soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.19, symbol Pb. (Dorland, 28th)

Teenager
type: Class
type: QualityValue
subclass of: Demographic
subclass of: Developmental Quality
notation: 137
definition: An individual between the ages of 13 and 19.
was approved by: PER-Jeanette-Stingone

5-10 Residence Building
type: Class
type: QualityValue
subclass of: Multi Residence Building
notation: 233
definition: A residential building that contains between five and ten apartments, town houses, condos, or other single family dwelling spaces.

Solid-Phase Sandwich ELISA
type: Class
subclass of: Sandwich ELISA
was approved by: PER-Jim-McCusker

4-hydroxyphenanthrene
type: Class
subclass of: PAH
notation: PHEN4

Monthly Income More Than $4,166
type: Class
type: QualityValue
subclass of: Household Income
notation: 294

2-amnothiazolne-4-carbxylic acid(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCATC
editorial note: To Do: align with CHEBI.

Liquid Chromatography - Tandem Mass Spectrometer
type: Class
subclass of: Tandem Mass Spectrometer
subclass of: Liquid Chromatography–Mass Spectrometer
definition: Liquid chromatography and tandem Mass Spectrometry. MS/MS is the combination of two mass analyzers in one mass spec instrument.
was approved by: PER-Jim-McCusker

Some Postgraduate
type: Class
type: QualityValue
subclass of: Higher Education
subclass of: Restriction
  some values from: NCIT C92860
  on property: SIO_000230
notation: 187
definition: Has begun postgraduate (masters, doctorate, etcl) and may or may not have matriculated with a graduate degree.

Nucleic Acid Sequencing
type: Class
subclass of: SIO_001007

femtoliter
type: SIO_000074
notation: fl

Physical Activity and Fitness
type: Class
subclass of: StudyIndicator
definition: Physical Activity and Fitness Indicator Class
was approved by: PER-Jeanette-Stingone

mono (5-carboxy-2-ethylpentyl) phthalate (DEHP)
type: Class
subclass of: Phthalate
notation: MCEPP

Cough
type: Class
subclass of: wheezing or tightness in the chest or cough

Barium
type: Class
subclass of: Metal
notation: Ba
definition: BARIUM is an element of the alkaline earth group of metals. It has an atomic symbol Ba, atomic number 56, and atomic weight 138. All of its acid-soluble salts are poisonous.

Emergency Medical Services Facility
type: Class
subclass of: Healthcare Facility

N-Acetyl-S- (3-hydroxypropyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: HPMA
editorial note: To Do: align with CHEBI.

Room Count
type: Class
type: QuantityVariable
subclass of: SIO_000794
subclass of: Housing Characteristic
definition: Total Number of Rooms in the Home
was approved by: PER-Jeanette-Stingone

centiMorgan
type: SIO_000074
notation: cM

Gas Chromatographer-Tandem Mass Spectrometer
type: Class
subclass of: Gas Chromatographer–Mass Spectrometer
subclass of: Tandem Mass Spectrometer
definition: MS/MS is the combination of two mass analyzers in one mass spec instrument.
was approved by: PER-Jim-McCusker

newton
type: SIO_000074
notation: Ntn

2, 4, 5-Trichlorophenol
type: Class
subclass of: Environmental Phenol
notation: TCP245
definition: Exposure to 2, 4, 5-trichlorophenol may occur during its production or use as a pesticide. Acute (short-term) dermal exposure to 2, 4, 5-trichlorophenol may burn skin in humans. It also irritates the eyes, nose, pharynx, and lungs in humans. No information is available on the chronic (long-term), reproductive, developmental, or carcinogenic effects of 2, 4, 5-trichlorophenol in humans. In one study, slight degenerative changes were observed in the liver and kidneys of rats chronically exposed to 2, 4, 5-trichlorophenol in their diet. EPA has classified 2, 4, 5-trichlorophenol as a Group D, not classifiable as to human carcinogenicity. PHYSICAL DESCRIPTION: Colorless needles, gray flakes or off-white lumpy solid. Phenolic odor. Formerly used as a fungicide and bactericide.

times per week
type: SIO_000074
type: SIO_000794
notation: times/week

2-Methylhippuric acid
type: Class
subclass of: Volatile Organic Compound
notation: MHA2
editorial note: To Do: align with CHEBI.

Overloaded filter
type: Class
subclass of: SIO_001167

Analysis Mode
type: Class
type: QualityVariable
subclass of: SampleIndicator
definition: Analysis Mode

Monthly Income $2,918 to $3,333
type: Class
type: QualityValue
subclass of: Household Income
notation: 291

bronchiolitis
type: Class
type: QualityValue
subclass of: lung disease
notation: 194

Value greater than ULOQ
type: Class
subclass of: SIO_001167

adult respiratory distress syndrome
type: Class
type: QualityValue
subclass of: SIO_010056
notation: 385

Matrix metalloproteinase-9
type: Class
subclass of: Protein
notation: MMP9

immune response
type: Class
type: QualityVariable
subclass of: Health Outcome
subclass of: SIO_000475

Food Or Beverage Product Reheated in a Plastic Container
type: Class
type: NodeShape
subclass of: food product
subclass of: Restriction
  some values from: Reheating Food or Beverage in a Plastic Container
  on property: SIO_000311
comment: Food (or beverage) that has been reheated inside a container made of plastic

Monomethylarsonic Acid
type: Class
subclass of: Arsenic Species
notation: Monomethylarsonic Acid

Clinical Observations Severity
type: Class
subclass of: Thing

N-Acetyl-S-(1, 2-dichlorovinyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: DCVMA12
editorial note: To Do: align with CHEBI.

Multi Residence Building
type: Class
type: QualityValue
subclass of: Human Dwelling
subclass of: Residential Building
notation: 231
definition: A residential building that contains more than one apartment, town house, condo, or other single family dwelling space.

SYNAPT G2-Si Mass Spectrometer
type: Class
subclass of: Hydrogen–Deuterium Exchange Mass Spectrometer
was approved by: PER-Jim-McCusker

Graduated From High School
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: High School or Less
notation: 32
definition: The quality of having graduated from High School
was approved by: PER-Jeanette-Stingone

2-Methylhippuric acid (ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOC2MH
editorial note: To Do: align with CHEBI.

Oral Health
type: Class
subclass of: StudyIndicator
definition: Oral Health Indicator Class
was approved by: PER-Jeanette-Stingone

Monthly Income $3,334 to $3,750
type: Class
type: QualityValue
subclass of: Household Income
notation: 292

Alcohol, Tobacco, and Illicit Drug Use
type: Class
subclass of: StudyIndicator
definition: Alcohol, Tobacco, and Illicit Drug Use Indicator Class
was approved by: PER-Jeanette-Stingone

Value below LLOQ, no LOD provided
type: Class
subclass of: SIO_001167

Fluticasone propionate DPI (Flovent Diskus)
type: Class
subclass of: Asthma Controller Medication

school
type: Class
type: NodeShape
subclass of: Organization
comment: An educational institution.

Multiracial
type: Class
type: QualityValue
subclass of: Race
subclass of: Non-White
notation: 54
definition: Having ancestors of several or various races.
was approved by: PER-Jeanette-Stingone
editorial note: Not part of current prov for Race. Should we remove this concept?

Eats Food Packaged in Plastic
type: Class
type: NodeShape
subclass of: Environmental Exposure
subclass of: Eating or Drinking
subclass of: Restriction
  some values from: Food Product Packaged in Plastic
  on property: SIO_000230
comment: The act of eating food that has been packaged in a plastic container.

antimalarial
type: Class
subclass of: drug

Parity
type: Class
type: QuantityVariable
subclass of: SIO_000794
subclass of: Pregnancy Characteristic
definition: The number of time that a viviparous organism has given birth
was approved by: PER-Jeanette-Stingone

Attribute
type: Class
subclass of: ScienceIndicator

Increased Body Weight
type: Class
type: QualityValue
subclass of: Body Weight Quality
subclass of: Restriction
  some values from: Restriction
    some values from: Class
      intersection of: Body Mass Index
      intersection of: Restriction
        some values from: Datatype
        on property: STATO_0000129
    on property: SIO_000008
  on property: SIO_000011
notation: 72
definition: BMI > 25

N-Acetyl-S- (2-carboxyethyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: CEMA
editorial note: To Do: align with CHEBI.

kilobasepair
type: SIO_000074
notation: kbp

Pregnancy Sample
type: Class
subclass of: Biospecimen
definition: A sample that is taken at or near pregnancy or birth.

Forceps-Assisted Birth
type: Class
type: QualityValue
subclass of: Vaginal Birth
notation: 25
definition: A vaginal birth with the assistance of forceps to extract the baby.

Oily Fish
type: Class
subclass of: fish
definition: Oily fish are fish that contain at least 2% fat by weight. (Oily Fish. (n.d.) Segen's Medical Dictionary. (2011))

Parental Health and Family History
type: Class
subclass of: StudyIndicator
definition: Parental Health and Family History Indicator Class
was approved by: PER-Jeanette-Stingone

Analyzed at a later date than rest of samples on worksheet (not a repeat)
type: Class
subclass of: SIO_001167

Beverage Packaged in Plastic
type: Class
type: NodeShape
subclass of: beverage
subclass of: Restriction
  some values from: plastic container
  on property: SIO_000128
comment: A liquid beverage that is packaged in a plastic container
equivalent class: Class
  intersection of: beverage
  intersection of: Restriction
    some values from: plastic container
    on property: SIO_000128
  equivalent class: Beverage Packaged in Plastic

4-hydroxybenzophenone
type: Class
subclass of: Benzophenone
notation: OH4BP

N-Acetyl-S- (3, 4-dihydroxybutyl)-L-cysteine
type: Class
subclass of: Volatile Organic Compound
notation: DHBMA
editorial note: To Do: align with CHEBI.

centiRay
type: SIO_000074
notation: cR

RNA Sequencing
type: Class
subclass of: Nucleic Acid Sequencing

Sustained Physical Activity
type: Class
type: QualityVariable
subclass of: Physical Activity
definition: Physical activity that is at least 30 minutes in duration.

Monthly Income $2,501 to $2,917
type: Class
type: QualityValue
subclass of: Household Income
notation: 290

Foster
type: Class
subclass of: Non-Biological Relative
definition: Fosterage, the practice of a family bringing up a child not their own, differs from adoption in that the child's parents, not the foster-parents, remain the acknowledged parents. In many modern western societies foster care can be organized by the state to care for children with troubled family backgrounds, usually on a temporary basis. In many pre-modern societies fosterage was a form of patronage, whereby influential families cemented political relationships by bringing up each other's children, similar to arranged marriages, also based on dynastic or alliance calculations.

Panel change
type: Class
subclass of: SIO_001167

Analyte
type: Class
subclass of: SIO_010004

Drinks Beverage Packaged in Plastic
type: Class
type: NodeShape
subclass of: Environmental Exposure
subclass of: Eating or Drinking
subclass of: Restriction
  some values from: Beverage Packaged in Plastic
  on property: SIO_000230
comment: The act of drinking a beverage that has been packaged in a plastic container.

PCB118
type: Class
subclass of: Polychlorobiphenyl
notation: PCB118

N-methyl Perfluorooctane sulfonamido acetic acid
type: Class
subclass of: PFC
notation: NMFOSAA

Intensive Care Unit
type: Class
type: QualityValue
subclass of: Destination
subclass of: Healthcare Facility
notation: 168
definition: A health care facility unit that provides intensive care to critically ill patients and patients with complex medical problems who require constant monitoring or special therapy.

Metabolite
type: Class
subclass of: Analyte
definition: A substance formed in or necessary for metabolism

Triclocarban
type: Class
subclass of: Environmental Phenol
notation: TCC
definition: Triclocarban is a triclosan analogue with an antibacterial property. Triclocarban exerts its effect by inhibiting the activity of enoyl-(acyl-carrier protein) (ACP) reductase, widely distributed in bacteria, fungi and plants. ACP reductase catalyses the last step in each cycle of fatty acid elongation in the type II fatty acid synthase systems. As a result, this agent interrupts cell membrane synthesis and leads to bacterial growth inhibition.

Pre-Pregnancy
type: Class
subclass of: SIO_000417
subclass of: From Conception
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: Conceiving
definition: The time before a pregnancy.
was approved by: PER-Jeanette-Stingone

Daughter
type: Class
subclass of: Child
subclass of: Restriction
  on property: isRoleOf
  all values from: Restriction
    some values from: SIO_010052
    on property: SIO_000008
definition: The female offspring in relation to her parents.

Annual Income $75,000 to $99,999
type: Class
type: QualityValue
subclass of: Annual Income More Than $70,001
notation: 421

Pregnancy Month 6
type: Class
subclass of: SIO_000417
definition: The sixth month of pregnancy

Annual Income $75,000 to $84,999
type: Class
type: QualityValue
subclass of: Annual Income $75,000 to $99,999
notation: 262

Functional Status Respiratory Status Score Below 2
type: Class
type: QualityValue
subclass of: Functional Status Respiratory Status Score
notation: 367

Ethyl mercury (C2H5Hg+)
type: Class
subclass of: Mercury Species
notation: C2H5Hg

parts per hundred
type: SIO_000074
notation: pph

megavolt
type: SIO_000074
notation: MV

hemoglobin measurement
type: Class
subclass of: Concentration

White
type: Class
type: QualityValue
subclass of: Race
notation: 102
definition: A person having origins in any of the original peoples of Europe, the Middle East, or North Africa.
was approved by: PER-Jeanette-Stingone

Glucan
type: Class
subclass of: Environmental Exposure

Prenatal Nonsmoker
type: Class
type: QualityValue
subclass of: Non-smoker
notation: 76
definition: Could be a former smoker or a non-smoker, so neither should be encoded as the superclass.
editorial note: Should this be a subClassOf PregnancyCharactistic as well?

Health Outcome
type: Class
subclass of: StudyIndicator

Annual Income $65,000 to $74,999
type: Class
type: QualityValue
subclass of: Annual Income $50,000 to $99,999
notation: 263

Comorbidity Disease
type: Class
type: QualityValue
subclass of: Disease
notation: 363

Public or No Insurance
type: Class
type: QualityValue
subclass of: Private Insurance or Self Pay
notation: 335

Father
type: Class
type: QualityValue
subclass of: Parent
subclass of: Restriction
  on property: isRoleOf
  all values from: Restriction
    some values from: SIO_010048
    on property: SIO_000008
notation: 188
definition: The male parent of a child. Besides the paternal bonds of a father to his children, the father may have a parental legal and social relationship with the child that carries with it certain rights and obligations. An adoptive father is a male who has become the child's parent through the legal process of adoption. A biological father is the male genetic contributor to the creation of the baby, through sexual intercourse or sperm donation. A biological father may have legal obligations to a child not raised by him, such as an obligation of monetary support. A putative father is a man whose biological relationship to a child is alleged but has not been established. A stepfather is a male who is the husband of a child's mother and they may form a family unit, but who generally does not have the legal rights and responsibilities of a parent in relation to the child.
was approved by: PER-Jeanette-Stingone

hematologic disease
type: Class
type: QualityValue
subclass of: Disease
notation: 404

Interleukin-9
type: Class
subclass of: Protein
notation: IL9

3-hydroxyfluorene
type: Class
subclass of: PAH
notation: FLUO3

picovolt
type: SIO_000074
notation: pV

Process
type: Class
subclass of: ScienceIndicator

3-Hydroxypropyl-1-methyl mercapturic acid + 3-Hydroxypropyl-2-methyl mercapturic acid + 3-Hydroxypropyl-3-methyl mercapturic acid
notation: HMPMA

2, 4, 5, 6-Tetrachlorophenol
type: Class
subclass of: Environmental Phenol
notation: TeCP2456
definition: PHYSICAL DESCRIPTION: Brown flakes or beige solid. Strong odor. (NTP, 1992)

Single-Family House
type: Class
type: QualityValue
subclass of: Residential Building
notation: 175
definition: A residential building designed to hold one family.

Annual Income $40,000 to $49,999
type: Class
type: QualityValue
subclass of: Annual Income $30,000 to $60,000
notation: 419

Average Folic Acid Supplement Intake
type: Class
type: QuantityVariable
subclass of: SIO_001109
subclass of: Uses Folic Acid Supplement

Monthly Income $2,084 to $2,500
type: Class
type: QualityValue
subclass of: Household Income
notation: 289

Planned Caesarian Section
type: Class
type: QualityValue
subclass of: Caesarian Section
notation: 18
definition: Planned caesarian section.
was approved by: PER-Jeanette-Stingone

Annual Income More Than $95,000
type: Class
type: QualityValue
subclass of: Annual Income More Than $70,001
notation: 260

year
type: SIO_000074
notation: y

Triclosan
type: Class
subclass of: Environmental Phenol
notation: TCS
definition: Triclosan is a diphenyl ether derivative used in cosmetics and toilet soaps as an antiseptic. It has some bacteriostatic and fungistatic action.

parts per million
type: SIO_000074
notation: ppm

Chest Tube
type: Class
type: NodeShape
subclass of: Medical Device
comment: A hollow tube that is inserted into the pleural space through a surgical incision in the chest wall. [Definition Source: NCI]

newton per meter
type: SIO_000074
notation: N/m

beverage food product
type: Class
type: NodeShape
subclass of: food product
comment: A liquid prepared for consumption, or a product that can be combined with water or milk to make one.

Tungsten
type: Class
subclass of: Metal
notation: W
definition: Tungsten. A metallic element with the atomic symbol W, atomic number 74, and atomic weight 183.85. TUNGSTEN is used in many manufacturing applications, including increasing the hardness, toughness, and tensile strength of steel; manufacture of filaments for incandescent light bulbs; and in contact points for automotive and electrical apparatus.

Femur
type: Class
subclass of: SIO_010046

2-Aminothiazoline-4-carboxylic acid
type: Class
subclass of: Volatile Organic Compound
notation: ATCA
editorial note: To Do: align with CHEBI.

Hemoglobin Genotype SS
type: Class
type: QualityValue
subclass of: Genotype
subclass of: SCD Genotype
notation: 346

Average B6 Supplement Intake
type: Class
type: QuantityVariable
subclass of: SIO_001109
subclass of: Uses B6 Supplement
equivalent class: Class
  union of: Public Insurance
  union of: No Insurance / Self-funded
  equivalent class: Average B6 Supplement Intake

Post-Pregnancy
type: Class
subclass of: SIO_000417
subclass of: From Birth
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: birthing
definition: The period after birth.
was approved by: PER-Jeanette-Stingone

Multi-Family House
type: Class
type: QualityValue
subclass of: Residential Building
notation: 176
definition: A residential building designed to hold more than one family.

FLOPO 0000089
type: Class
subclass of: SIO_010056

Annual Income $85,000 to $94,999
type: Class
type: QualityValue
subclass of: Annual Income $75,000 to $99,999
notation: 261

Annual Income $50,000 to $74,999
type: Class
type: QualityValue
subclass of: Annual Income $50,000 to $99,999
notation: 420

Transfer
type: Class
type: QualityValue
subclass of: Destination
notation: 172
definition: The act of conveying or transporting from one place to another.

Functional Status Respiratory Status Score 2 or Above
type: Class
type: QualityValue
subclass of: Functional Status Respiratory Status Score
notation: 366

parts per thousand
type: SIO_000074
notation: ppth

month
type: SIO_000074
notation: m

katal
type: SIO_000074
notation: kat

bone marrow proteoglycan proteolytic cleavage product
type: Class
type: NodeShape
subclass of: SIO_010363

Monthly Income $1,251 to $1,666
type: Class
type: QualityValue
subclass of: Household Income
notation: 287

Descendant
type: Class
subclass of: Relative
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: Restriction
      on property: hasRole
      all values from: Ancestor
    intersection of: SIO_000485
definition: The child of a human, or any grandchild, great-grandchild, and so on.
was approved by: PER-Jeanette-Stingone

2, 3', 4, 4'-Tetrabromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
notation: BDE66
editorial note: To Do: align with CHEBI.

Annual Income $90,001 to $120,000
type: Class
type: QualityValue
subclass of: Annual Income More Than $70,001
notation: 165
definition: Personal or family annual income bwtween $90,001 and $120,000

immune system disease
type: Class
type: QualityValue
subclass of: Comorbidity Disease
notation: 405

Phenylglyoxylic acid
type: Class
subclass of: Volatile Organic Compound
notation: PGA
editorial note: To Do: align with CHEBI.

micromole
type: SIO_000074
notation: µmol

nanograms per liter
type: SIO_000074
notation: ng/L

Annual Income $20,000 to $29,999
type: Class
type: QualityValue
subclass of: Annual Income $15,000 to $29,999
subclass of: Annual Income $15,001 to $30,000
notation: 417

Uses B6 Supplement
type: Class
type: QualityValue
subclass of: nutrition intake
subclass of: Restriction
  some values from: B6 Vitamin Supplement
  on property: SIO_000139
notation: 334

radian
type: SIO_000074
notation: rad

microampere
type: SIO_000074
notation: µA

Platelet
type: Class
subclass of: Blood Component
definition: A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation.

No preservative added
type: Class
subclass of: SIO_001167

behavioral phenotype
type: Class
subclass of: SIO_010056

Short Stay
type: Class
type: QualityValue
subclass of: Destination
notation: 170
definition: A patient encounter where the patient is admitted to a health care facility for a predetermined length of time, usually less than 24 hours. [def-source:

Trans-Nonachlor
type: Class
subclass of: Organochlorine Compound
notation: TNON

2, 4, 4'-Tribromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
notation: BDE28
editorial note: To Do: align with CHEBI.

Annual Income $30,000 to $39,999
type: Class
type: QualityValue
subclass of: Annual Income $30,000 to $49,999
notation: 418

Phenylglyoxylic acid(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCPHG
editorial note: To Do: align with CHEBI.

Monthly Income $1,667 to $2,083
type: Class
type: QualityValue
subclass of: Household Income
notation: 288

Annual Income More Than $120,000
type: Class
type: QualityValue
subclass of: Annual Income More Than $100,000
notation: 166
definition: Personal or family annual income greater than $120,000

Never exposed to second hand smoke from E-cigarettes
type: Class
type: QualityValue
subclass of: environmental e-cigarette smoke exposure
notation: 259

First
type: Class
subclass of: Thing

Car
type: Class
type: QualityValue
subclass of: Human Dwelling
notation: 248

Average Iron Supplement Intake
type: Class
type: QuantityVariable
subclass of: SIO_001109
subclass of: Uses Iron Supplement

dyne per cm
type: SIO_000074
notation: dyn/cm

milliampere
type: SIO_000074
notation: mA

No Hct, Hct=40 assumed
type: Class
subclass of: SIO_001167

Shannon diversity index
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment
subclass of: Health Outcome
subclass of: community species diversity

Medical Therapy Procedure
type: Class
type: QualityVariable
subclass of: Medical History
subclass of: SIO_001024
definition: Medical Therapy Procedure to aide in treatment.
was approved by: PER-Jeanette-Stingone

2, 2', 4, 4', 6-Pentabromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
notation: BDE100
editorial note: To Do: align with CHEBI.

Benzo[a]pyrene tetraol
type: Class
subclass of: PAH
notation: BAPT

Annual Income $50,001 to $75,000
type: Class
type: QualityValue
subclass of: Annual Income $50,000 to $99,999
notation: 163
definition: Personal or family annual income bwtween $50,001 and $75,000

decibel
type: SIO_000074
notation: dB

Annual Income $5,000 to $9,999
type: Class
type: QualityValue
type: NodeShape
subclass of: Annual Income $14,999 or Less
notation: 415

Uses Folic Acid Supplement
type: Class
type: QualityValue
subclass of: nutrition intake
subclass of: Restriction
  some values from: Folic Acid Vitamin Supplement
  on property: SIO_000139
notation: 333

Monthly Income $417 to $833
type: Class
type: QualityValue
subclass of: Household Income
notation: 285

picogram per milliliter
type: SIO_000074
notation: pg/mL

steradian
type: SIO_000074
notation: sr

poise
type: SIO_000074
notation: Poise

colony forming unit
type: SIO_000074
notation: cfu

Congenital Abnormality
type: Class
subclass of: Disease
subclass of: Congenital anomaly or chromosomal defect

Obvious coarse debris
type: Class
subclass of: SIO_001167

neuron
type: Class
subclass of: Cell

Healthcare Facility
type: Class
type: NodeShape
subclass of: Organization
comment: The buildings and organizations where healthcare services are provided.

Home
type: Class
type: QualityValue
subclass of: Destination
notation: 167
definition: A person's place of residence.

Birth
type: Class
subclass of: SIO_000417
subclass of: Beginning
subclass of: From Birth
definition: The ending of a pregnancy by one or more babies leaving a woman's uterus by vagina passage or c-section.
was approved by: PER-Jeanette-Stingone

Monthly Income $834 to $1,250
type: Class
type: QualityValue
subclass of: Household Income
notation: 286

2, 2', 4, 4'-Tetrabromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
notation: BDE47
editorial note: To Do: align with CHEBI.

B6 Vitamin Supplement
type: Class
subclass of: Vitamin
subclass of: Restriction
  some values from: CHEBI_27306
  on property: SIO_000313

Perfluroundecanoic acid
type: Class
subclass of: PFC
notation: PFUNDA

Annual Income $75,001 to $90,000
type: Class
type: QualityValue
subclass of: Annual Income $75,000 to $99,999
notation: 164
definition: Personal or family annual income bwtween $75,001 and $90,000

Mometasone HFA (Asmanex HFA)
type: Class
subclass of: Asthma Controller Medication

octadecanoic acid
type: Class
subclass of: Fatty Acid
notation: C180
definition: A C18 straight-chain saturated fatty acid component of many animal and vegetable lipids. As well as in the diet, it is used in hardening soaps, softening plastics and in making cosmetics, candles and plastics.

1-hydroxypyrene
type: Class
subclass of: PAH
notation: PYR1

Annual Income $10,000 to $19,999
type: Class
type: QualityValue
subclass of: Household Income
notation: 416

Non-Neoplastic Lung Disorder
type: Class
subclass of: SIO_000475

eosinophilic esophagitis
type: Class
subclass of: esophageal disease

pascal second
type: SIO_000074
notation: Pas

Cerebral Malaria
type: Class
type: QualityValue
subclass of: Malaria
notation: 126
definition: A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle.

Red Blood Cell
type: Class
subclass of: Blood Component
definition: A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen.

SIO_000751
type: QualityValue
notation: 133

Not Current Student
type: Class
type: QualityValue
subclass of: Educational Status
notation: 141
definition: The state of an individual not currently engaged in educational activity as a pupil.

Education
type: Class
type: QualityVariable
subclass of: Demographic
subclass of: Socioeconomic Status
subclass of: SIO_000026
definition: The act or process of imparting or acquiring knowledge.
was approved by: PER-Jeanette-Stingone

2, 4'-DDT
type: Class
subclass of: Organochlorine Compound
notation: OPDDT

Relative Time
type: Class
subclass of: SIO_000391
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: Process
definition: A time in relation to an event

ICU Admission By Re-admission Status
type: Class
type: QualityVariable
type: NodeShape
subclass of: Healthcare Access
subclass of: ICU Admission
comment: A subclass of ICU Admission; this class is used to distinguish between admissions of patients for the first time versus when a patient is readmitted to the ICU after previously being discharged.

Post Ventilation Childhood Followup 2
type: Class
subclass of: Childhood Followup 2
comment: A second follow-up evaluation that occurs after the subject has been removed from artificial ventilation.

Mean Concentration Range 200 - 500 ng/mL
type: Class
type: QualityValue
subclass of: Mean Concentration
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001114
    intersection of: Restriction
      on property: SIO_000300
      has value: 500.0
  on property: SIO_000216
subclass of: Restriction
  on property: SIO_000221
  has value: nanogram per milliliter
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 200.0
  on property: SIO_000216
notation: 320

ICU Admission
type: Class
subclass of: Healthcare Facility Admission
subclass of: Restriction
  some values from: Intensive Care Unit
  on property: SIO_000061
comment: The event of admitting some patient into the ICU.

Environmental Exposure
type: Class
subclass of: StudyIndicator
definition: EnvironmentalExposure Indicator Class
was approved by: PER-Jeanette-Stingone
editorial note: may need to refine this name in order to clearly differentiate from environmental exposures measured within CHEAR. Perhaps ExternalEnvironmental Exposure. Ok for now but we may want to discuss.

Thallium
type: Class
subclass of: Metal
notation: Tl
definition: THALLIUM is a heavy, bluish white metal, atomic number 81, atomic weight [204.382; 204.385], symbol Tl.

Methylation Assay
type: Class
subclass of: SIO_001007
definition: An assay that measures the methylation levels of sections of a genome.

arteriosclerotic cardiovascular disease
type: Class
subclass of: Disease

mono-(2-ethylhexyl) terephthalate
notation: MEHTP

Infinium Methylation EPIC BeadChip Assay
type: Class
subclass of: Microarray Assay
subclass of: Methylation Assay

cell in vitro
type: Class
subclass of: Cell

Interleukin-1 beta
type: Class
subclass of: Protein
notation: IL1B
definition: Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells.

Analysis
type: Class
subclass of: Analyte
definition: The value contains concentrations from the study sample

ICU Readmission
type: Class
type: QualityValue
subclass of: Restriction
  some values from: ICU Discharge
  on property: SIO_000249
subclass of: ICU Admission By Re-admission Status
comment: The event of re-admitting some patient into an ICU after they had previously been discharged.
notation: 373
equivalent class: Class
  intersection of: ICU Admission
  intersection of: Restriction
    some values from: ICU Discharge
    on property: SIO_000249
  equivalent class: ICU Readmission
disjoint with: ICU First Admission

ICU First Admission
type: Class
type: QualityValue
type: NodeShape
subclass of: ICU Admission By Re-admission Status
subclass of: Class
  complement of: Restriction
    some values from: ICU Discharge
    on property: SIO_000249
comment: This class denotes the first time a patient is admitted to an ICU.
notation: 432
equivalent class: Class
  intersection of: ICU Admission
  intersection of: Class
    complement of: Restriction
      some values from: ICU Discharge
      on property: SIO_000249
  equivalent class: ICU First Admission
disjoint with: ICU Readmission

Mean Concentration Range 500 - 1000 ng/mL
type: Class
type: QualityValue
subclass of: Mean Concentration
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001114
    intersection of: Restriction
      on property: SIO_000300
      has value: 1000.0
  on property: SIO_000216
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 500.0
  on property: SIO_000216
subclass of: Restriction
  on property: SIO_000221
  has value: nanogram per milliliter
notation: 321

Hexachlorobenzene
type: Class
subclass of: Organochlorine Compound
notation: HCB

Electrospray Ionization Mass Spectrometry
type: Class
subclass of: MassSpectrometry
definition: Mass spectrometry using ESI is called electrospray ionization mass spectrometry (ESI-MS) or, less commonly, electrospray mass spectrometry (ES-MS). ESI is a so-called 'soft ionization' technique, since there is very little fragmentation. This can be advantageous in the sense that the molecular ion (or more accurately a pseudo molecular ion) is always observed, however very little structural information can be gained from the simple mass spectrum obtained. This disadvantage can be overcome by coupling ESI with tandem mass spectrometry (ESI-MS/MS). Another important advantage of ESI is that solution-phase information can be retained into the gas-phase.
was approved by: PER-Jim-McCusker

Mental Health
type: Class
subclass of: Physical And Mental Assessment
definition: Mental Health Indicator
was approved by: PER-Jeanette-Stingone

Breast Feeding
type: Class
type: NodeShape
subclass of: Feeding Method
comment: The nursing of an infant at the mother's breast. [Definition Source: NCI]

Insurance Type
type: Class
type: QualityVariable
subclass of: Insurance
definition: Insurance Type

FEV1/FVC Ratio
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment

Departure
type: Class
type: QualityValue
subclass of: Destination
notation: 174
definition: The act of leaving a destination.

femtomolar
type: SIO_000074
notation: fM

hypertension
type: Class
type: QualityValue
subclass of: artery disease
notation: 178

From Birth
type: Class
subclass of: Relative Time
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: birthing
definition: A time in relation to a birth

Home Medical Technology
type: Class
type: QualityValue
subclass of: SIO_001398
notation: 364

Mean Concentration Range 30 - 100 ng/mL
type: Class
type: QualityValue
subclass of: Mean Concentration
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 30.0
  on property: SIO_000216
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001114
    intersection of: Restriction
      on property: SIO_000300
      has value: 100.0
  on property: SIO_000216
subclass of: Restriction
  on property: SIO_000221
  has value: nanogram per milliliter
notation: 318

Annual Income $15,000 to $24,999
type: Class
type: QualityValue
subclass of: Annual Income $15,000 to $29,999
notation: 268

Mobile Home
type: Class
type: QualityValue
subclass of: Human Dwelling
notation: 247

3, 4-Dihydroxy-benzoic acid methyl ester
type: Class
subclass of: Environmental Phenol
notation: OHMeP

ICU Admission Not Requiring Blood Transfusion
type: Class
type: QualityValue
type: NodeShape
subclass of: ICU Admission By Blood Transfusion Status
subclass of: Class
  complement of: Restriction
    some values from: blood transfusion
    on property: SIO_000250
comment: An ICU Admission of a patient that does not require a blood transfusion upon admission.
notation: 431
equivalent class: Class
  intersection of: ICU Admission
  intersection of: Class
    complement of: Restriction
      some values from: blood transfusion
      on property: SIO_000250
  equivalent class: ICU Admission Not Requiring Blood Transfusion
disjoint with: ICU Admission Requiring Blood Transfusion

Exposure Monitoring Instrument
type: Class
subclass of: PhysicalInstrument
definition: A physical instrument that monitors the environment for chemical exposures.
was approved by: PER-Jim-McCusker

Microarray Assay
type: Class
subclass of: SIO_001007
definition: An assay that uses a microarray to perform measurements.

mole fraction
type: SIO_000074
notation: chi

4, 4'-cyclo-hexylidenebisphenol
type: Class
notation: BPZ

Circumference
type: Class
type: QuantityVariable
subclass of: Anthropometry

Mean Concentration Range 100 - 200 ng/mL
type: Class
type: QualityValue
subclass of: Mean Concentration
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001114
    intersection of: Restriction
      on property: SIO_000300
      has value: 200.0
  on property: SIO_000216
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 100.0
  on property: SIO_000216
subclass of: Restriction
  on property: SIO_000221
  has value: nanogram per milliliter
notation: 319

From Conception
type: Class
subclass of: Relative Time
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: Conceiving
definition: A time in relation to a conception

Post Ventilation Childhood Followup
type: Class
subclass of: Childhood Followup
comment: A follow-up evaluation that occurs after the subject has been removed from artificial ventilation.

Monoisopropyl phthalate
type: Class
subclass of: Phthalate
notation: MiPP

Arsenobetaine
type: Class
subclass of: Arsenic Species
notation: Arsenobetaine

Hospital Readmission
type: Class
subclass of: Hospital Admission
subclass of: Restriction
  some values from: Hospital Discharge
  on property: SIO_000249
comment: The event of re-admitting some patient into a hospital after they had previously been discharged.

Hospital Admission By Admission Type
type: Class
type: QualityVariable
type: NodeShape
subclass of: Healthcare Access
subclass of: Hospital Admission
comment: A subclass of Hospital Admission; this class is used to differentiate the reasons for the hospital admission, Medical, Surgical, or Trauma.

Enzyme Immunoassay
type: Class
subclass of: Immunoassay

MicroPEM
type: Class
subclass of: Exposure Monitoring Instrument
definition: The MicroPEM device monitors individual exposures to very fine airborne particles—or particulate matter—at two sizes. PM10 has a diameter of less than 10 micrometers (PM10), which is approximately 1/30th the size of a human hair, and PM2.5, which at diameters of less than 2.5 micrometers, is even smaller.
was approved by: PER-Jim-McCusker

ingestion
type: Class
subclass of: SIO_000475

normal
type: SIO_000074
notation: Norm

Hospital Readmissions
type: Class
subclass of: SIO_000794
subclass of: Hospital Utilization
definition: An episode when a patient who had been discharged from a hospital is admitted again within a specified time interval.

microeinstein per square meter per second
type: SIO_000074
notation: µeinstein/sm2

Entity
type: Class
subclass of: ScienceIndicator

Quit Smoking
type: Class
type: QualityValue
subclass of: Previous Smoker
notation: 82
definition: Quit Smoking Cigarettes

Birth Weight
type: Class
type: QuantityVariable
subclass of: Thing
equivalent class: Class
  intersection of: SIO_000279
  intersection of: Restriction
    on property: SIO_000793
    all values from: Birth
  equivalent class: Birth Weight

Annual Income $35,000 to $44,999
type: Class
type: QualityValue
subclass of: Annual Income $30,001 to $50,000
notation: 266

Inductively Coupled Plasma Mass Spectrometer
type: Class
subclass of: Mass Spectrometer
definition: A type of mass spectrometry which is capable of detecting metals and several non-metals at concentrations as low as one part in 10^15 (part per quadrillion, ppq) on non-interfered low-background isotopes. This is achieved by ionizing the sample with inductively coupled plasma and then using a mass spectrometer to separate and quantify those ions.
was approved by: PER-Jim-McCusker

ICU Admission By Blood Transfusion Status
type: Class
type: QualityVariable
type: NodeShape
subclass of: ICU Admission
comment: A subclass of ICU Admission; it is used to differentiate between when patients require a blood transfusion during their ICU admission versus when they do not.

Pediatric Risk of Mortality Score (PRISM III)
type: Class
subclass of: Physical And Mental Assessment
subclass of: Score
comment: "The PRISM III score has 17 physiologic variables subdivided into 26 ranges. The variables most predictive of mortality were minimum systolic blood pressure, abnormal pupillary reflexes, and stupor/coma. Other risk factors, including two acute and two chronic diagnoses, and four additional risk factors, were used in the final predictors." (See skos:editorialNote for reference)
editorial note: This concept is taken from PRISM III: an updated Pediatric Risk of Mortality score M M Pollack 1, K M Patel, U E Ruttimann PMID: 8706448 DOI: 10.1097/00003246-199605000-00004 https://pubmed.ncbi.nlm.nih.gov/8706448/

Mean Concentration Range 0 - 10 ng/mL
type: Class
type: QualityValue
subclass of: Mean Concentration
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 0.0
  on property: SIO_000216
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001114
    intersection of: Restriction
      on property: SIO_000300
      has value: 10.0
  on property: SIO_000216
subclass of: Restriction
  on property: SIO_000221
  has value: nanogram per milliliter
notation: 316

mass percentage
type: SIO_000074
notation: w/w

radian per second per second
type: SIO_000074
notation: alpha

Vitamin
type: Class
subclass of: Thing

picosecond
type: SIO_000074
notation: ps

chromosomal aberration
type: Class
subclass of: Disease
subclass of: Congenital anomaly or chromosomal defect

Annual Income $25,000 to $34,999
type: Class
type: QualityValue
subclass of: Annual Income $20,001 to $40,000
notation: 267

Home Ventilation
type: Class
subclass of: Home Medical Technology
subclass of: artificial respiration
subclass of: Restriction
  some values from: Home
  on property: SIO_000061

Experimental Group
type: Class
type: QualityValue
subclass of: Population Group
notation: 201
definition: A study population that receives the intervention that is the focus of the study.

Beginning
type: Class
subclass of: Relative Time
subclass of: Restriction
  on property: SIO_000300
  has value: 1
definition: A time relative to the beginning of an event

Immunoturbidimetry
type: Class
subclass of: SIO_001007
definition: An analytical technique that uses light scattering, a physical phenomenon resulting from the interaction of light with particles in solution, to measure the concentration of particles. The photometric signal is generated by a decrease in light intensity as a direct consequence of increasing turbidity in the reaction well. Immunoturbidimetry uses the classical antigen-antibody reaction. The antigen-antibody complexes are particles which can be optically detected by an photometer.
was approved by: PER-Jim-McCusker

Environmental Material
type: Class
subclass of: SIO_010412

ICU Admission Requiring Blood Transfusion
type: Class
type: QualityValue
type: NodeShape
subclass of: ICU Admission By Blood Transfusion Status
subclass of: Restriction
  some values from: blood transfusion
  on property: SIO_000250
comment: An ICU Admission of a patient that requires a blood transfusion upon admission.
notation: 430
equivalent class: Class
  intersection of: ICU Admission
  intersection of: Restriction
    some values from: blood transfusion
    on property: SIO_000250
  equivalent class: ICU Admission Requiring Blood Transfusion
disjoint with: ICU Admission Not Requiring Blood Transfusion

Season
type: Class
type: QualityValue
subclass of: SIO_000417
subclass of: Environmental Exposure
notation: 209

Mean Concentration Range 10 - 30 ng/mL
type: Class
type: QualityValue
subclass of: Mean Concentration
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001114
    intersection of: Restriction
      on property: SIO_000300
      has value: 30.0
  on property: SIO_000216
subclass of: Restriction
  on property: SIO_000221
  has value: nanogram per milliliter
subclass of: Restriction
  some values from: Class
    intersection of: SIO_001113
    intersection of: Restriction
      on property: SIO_000300
      has value: 10.0
  on property: SIO_000216
notation: 317

Histidine-rich protein PFHRP-II
type: Class
subclass of: Protein

Measurement
type: Class
type: QualityVariable
subclass of: Physical And Mental Assessment

Phthalate
type: Class
subclass of: Targeted Analyte

meter per second per second
type: SIO_000074
notation: m/s2

Nail
type: Class
subclass of: Tissue
definition: A nail that is part of a manual digit. [database_cross_reference: OBOL:automatic]

gamma-hexachlorocyclohexane
type: Class
subclass of: Organochlorine Compound
notation: GHCH

watt per steradian
type: SIO_000074
notation: W/sr

room
type: Class
subclass of: Thing

(9Z)-hexadecenoic acid
type: Class
subclass of: Fatty Acid
notation: C161N7
definition: A hexadecenoic acid with a cis-double bond at position C-9.

Alta, Far Northern, and Redwood Coast
type: Class
type: QualityValue
subclass of: Population Group
notation: 336

Prenatal Smoker
type: Class
type: QualityValue
subclass of: Smoker
notation: 77
definition: The quality of having smoked while being pregnant.
editorial note: Should this be a subClassOf PregnancyCharactistic as well?

Mother
type: Class
type: QualityValue
subclass of: Parent
subclass of: Restriction
  on property: isRoleOf
  all values from: Restriction
    some values from: SIO_010052
    on property: SIO_000008
notation: 189
definition: A mother is the female parent of a child. Mothers are women who inhabit or perform the role of bearing some relation to their children, who may or may not be their biological offspring. Thus, dependent on the context, women can be considered mothers by virtue of having given birth, by raising their child(ren), supplying their ovum for fertilisation, or some combination thereof. Such conditions provide a way of delineating the concept of motherhood, or the state of being a mother. Women who meet the third and first categories usually fall under the terms 'birth mother' or 'biological mother', regardless of whether the individual in question goes on to parent their child. Accordingly, a woman who meets only the second condition may be considered an adoptive mother, and those who meet only the third a surrogacy mother. The above concepts defining the role of mother are neither exhaustive nor universal, as any definition of 'mother' may differ based on how social, cultural, and religious roles are defined.
was approved by: PER-Jeanette-Stingone

Antibiotic Score
type: Class
subclass of: Score
subclass of: Prescription Medication and Dietary Supplements
comment: Antibiotic Score is the total coverage score that was based on whether the antibiotic included coverage against gram-positive bacteria, gram-negative bacteria and/or anaerobic bacteria. Coverage in each area was graded on a 3-point scale: 0 for no activity, 1 for narrow activity, and 2 for broad activity. For patients treated with multiple antibiotics simultaneously, the score for each antibiotic received on a given day was summed. Cumulative scores were summed across days.

5+ Years of College, Technical, or Vocational Training
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: Higher Education
notation: 315

Annual Income $55,000 to $64,999
type: Class
type: QualityValue
subclass of: Annual Income $50,001 to $75,000
subclass of: Annual Income $50,000 to $74,999
notation: 264

Electron-Detachment Dissociation (EDD)
type: Class
subclass of: TandemMassSpectrometry

Liquid Chromatography Instrument
type: Class
subclass of: Chromatography Instrument
definition: A separation technique in which the mobile phase is a liquid. It can be carried out either in a column or a plane. Present day liquid chromatography that generally utilizes very small packing particles and a relatively high pressure is referred to as high performance liquid chromatography (HPLC).
was approved by: PER-Jim-McCusker

Protocatechuic acid ethyl ester
type: Class
subclass of: Environmental Phenol
notation: OHEtP

Lymphocyte
type: Class
subclass of: Leukocyte
definition: A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.

sequence_collection
type: Class
type: NodeShape
subclass of: SIO_000030

hour
type: SIO_000074
notation: h

Medical Device
type: Class
type: NodeShape
subclass of: PhysicalInstrument
comment: Any physical object that is useful for prevention, diagnosis, monitoring, or treatment of disease or other conditions. [Definition Source: NCI]

volume percentage
type: SIO_000074
notation: %(v/v)

nanovolt
type: SIO_000074
notation: nV

Private Insurance
type: Class
type: QualityValue
subclass of: Private Insurance or Self Pay
notation: 103

North Bay
type: Class
type: QualityValue
subclass of: Population Group
notation: 337

Annual Income $45,000 to $54,999
type: Class
type: QualityValue
subclass of: Household Income
subclass of: Annual Income $40,001 to $70,000
notation: 265

Corticosteroid Burst
type: Class
type: QuantityVariable
subclass of: Prescription Medication and Dietary Supplements
subclass of: SIO_001398
subclass of: Restriction
  some values from: SIO_000393
  on property: SIO_000291
subclass of: Restriction
  some values from: CHEBI_50858
  on property: SIO_000230

Known Food Allergies
type: Class
type: QualityVariable
subclass of: Health Outcome

Son
type: Class
subclass of: Child
subclass of: Restriction
  on property: isRoleOf
  all values from: Restriction
    some values from: SIO_010048
    on property: SIO_000008
definition: A son is a male offspring; a boy or man in relation to his parents.

Toluene
type: Class
subclass of: Volatile Organic Compound
notation: TOL
definition: Toluene is a widely used industrial solvent.

duration hospital admission to urine sample
type: Class
type: QuantityVariable
subclass of: SIO_000417
subclass of: Physical And Mental Assessment
subclass of: PATO_0001309

Hospitalization
type: Class
type: QualityValue
subclass of: SIO_001024
subclass of: Hospital Utilization
notation: 104
definition: Admission to a hospital

radian per second
type: SIO_000074
notation: rad/s

mass volume percentage
type: SIO_000074
notation: (w/v)

minute
type: SIO_000074
notation: min

4, 4'-DDE
type: Class
subclass of: Organochlorine Compound
notation: PPDDE

hexadecanoic acid
type: Class
subclass of: Fatty Acid
notation: C160
definition: A straight-chain, sixteen-carbon, saturated long-chain fatty acid.

Invalid Allergy Test
type: Class
type: QualityValue
subclass of: Invalid Test
subclass of: Allergy Test
notation: 358
equivalent class: Class
  intersection of: Invalid Test
  intersection of: Allergy Test
  equivalent class: Invalid Allergy Test

deciliter
type: SIO_000074
notation: dl

gamma-linolenic acid
type: Class
subclass of: Fatty Acid
notation: C183N6
definition: A C18, ω-6 acid fatty acid comprising a linolenic acid having cis- double bonds at positions 6, 9 and 12.

Gas Chromatographer–Mass Spectrometer
type: Class
subclass of: Gas Chromatography Instrument
subclass of: Mass Spectrometer
definition: Gas chromatography–mass spectrometry (GC-MS) is an analytical method that combines the features of gas-chromatography and mass spectrometry to identify different substances within a test sample. Applications of GC-MS include drug detection, fire investigation, environmental analysis, explosives investigation, and identification of unknown samples, including that of material samples obtained from planet Mars during probe missions as early as the 1970s. GC-MS can also be used in airport security to detect substances in luggage or on human beings. Additionally, it can identify trace elements in materials that were previously thought to have disintegrated beyond identification. Like liquid chromatography–mass spectrometry, it allows analysis and detection even of tiny amounts of a substance.
was approved by: PER-Jim-McCusker

micrograms per deciliter
type: SIO_000074
notation: µg/dl

Small clot present
type: Class
subclass of: SIO_001167

Phenotypic abnormality
type: Class
subclass of: SIO_000475

Parent
type: Class
subclass of: Ancestor
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: Restriction
      on property: hasRole
      all values from: Child
    intersection of: SIO_000485
definition: A parent is the caretaker of a child (where "child" refers to offspring, not necessarily age). A biological parent is a person whose gamete resulted in a child, a male through the sperm, and a female through the ovum. Parents are first-degree relatives and have 50% genetic meet. A female can also become a parent through surrogacy. Some parents may be adoptive parents, who nurture and raise an offspring, but are not actually biologically related to the child. Orphans without adoptive parents can be raised by their grandparents or other family members.
was approved by: PER-Jeanette-Stingone

Metabolite
type: Class
subclass of: Small Molecule
definition: The intermediates and products of metabolism. The term metabolite is usually restricted to small molecules. Metabolites have various functions, including fuel, structure, signaling, stimulatory and inhibitory effects on enzymes, catalytic activity of their own (usually as a cofactor to an enzyme), defense, and interactions with other organisms (e.g. pigments, odorants, and pheromones). A primary metabolite is directly involved in normal "growth", development, and reproduction. Ethylene is an example of a primary metabolite produced in large-scale by industrial microbiology. A secondary metabolite is not directly involved in those processes, but usually has an important ecological function. Examples include antibiotics and pigments such as resins and terpenes etc. Some antibiotics use primary metabolites as precursors, such as actinomycin which is created from the primary metabolite, tryptophan.

Annual Income $14,999 or Less
type: Class
type: QualityValue
subclass of: Household Income
notation: 219

Electron Capture Dissociation (ECD)
type: Class
subclass of: TandemMassSpectrometry

Destination
type: Class
type: QualityVariable
subclass of: Healthcare Access
notation: Dest
definition: A place to which one is traveling or to which something is sent.

Whole Blood
type: Class
subclass of: Bodily Fluid
definition: A fluid that is composed of blood plasma and erythrocytes. [database_cross_reference: http://orcid.org/0000-0002-6601-2165][database_cross_reference: http://en.wikipedia.org/wiki/Blood][database_cross_reference: https://github.com/obophenotype/uberon/issues/9][database_cross_reference: FMA:9670]

Creatinine
type: Class
subclass of: Targeted Analyte
notation: CRE
definition: Creatinine is the breakdown product of creatine, a constituent of muscle tissue, that is excreted by the kidney and whose serum level is used to evaluate kidney function.

Eosinophil Percentage
type: Class
type: QuantityVariable
subclass of: Physical And Mental Assessment

Mometasone DPI (Asmanex)
type: Class
subclass of: Asthma Controller Medication

Haptoglobin
type: Class
subclass of: Protein
notation: HAPTOGLOBIN

admission diagnosis
type: Class
subclass of: Health Outcome
subclass of: Restriction
  some values from: Admission
  on property: SIO_000687
subclass of: SIO_001331
comment: A medical diagnosis that occurs at admission to a hospital or other medical care provider.

gram per deciliter
type: SIO_000074
notation: g/dl

2, 3, 4, 5-Tetrachlorophenol
type: Class
subclass of: Environmental Phenol
notation: TeCP2345
definition: PHYSICAL DESCRIPTION: Needles (from petroleum ether, ligroin) or beige solid. (NTP, 1992)

Allergy
type: Class
type: QualityValue
subclass of: SIO_010056
notation: 279

Perfluorooctanesulfonate
type: Class
subclass of: PFC
notation: PFDODA

HPLC with Fluorescence Level Detector
type: Class
subclass of: High-Performance Liquid Chromatography
definition: HPLC paired with a Fluorescence Level Detector. Fluorescence spectroscopy (also known as fluorometry or spectrofluorometry) is a type of electromagnetic spectroscopy that analyzes fluorescence from a sample. It involves using a beam of light, usually ultraviolet light, that excites the electrons in molecules of certain compounds and causes them to emit light; typically, but not necessarily, visible light. A complementary technique is absorption spectroscopy. In the special case of single molecule fluorescence spectroscopy, intensity fluctuations from the emitted light are measured from either single fluorophores, or pairs of fluorophores.

Slightly hemolyzed
type: Class
subclass of: SIO_001167

Ultra-Performance Liquid Chromatography - Tandem Mass Spectrometer
type: Class
subclass of: Tandem Mass Spectrometer
subclass of: Ultra Performance Liquid Chromatography - Mass Spectrometer
was approved by: PER-Jim-McCusker

Metal
type: Class
subclass of: Element
definition: For environmental purposes, HHEAR metals are metals and metalliods, as originally defined in CHEAR.

Household Appliance Count
type: Class
type: QuantityVariable
subclass of: SIO_000794
subclass of: Housing Characteristic
definition: Total number of appliances that can be found in the home.
was approved by: PER-Jeanette-Stingone

Early Childhood Vigilance Test
type: Class
subclass of: Neurocognitive Assessment
definition: a computer-based assessment of sustained attention during which the child is required to watch a screen where various animated stimuli disappear and reappear

Annual Income $15,000 to $29,999
type: Class
type: QualityValue
subclass of: Household Income
notation: 220

2, 4-Dichlorophenol
type: Class
subclass of: Environmental Phenol
notation: DCP24
definition: 2, 4-dichlorophenol is a colorless crystalline solid with a medicinal odor. Melting point 45°C. Sinks in water. Strong irritant to tissues; toxic by ingestion.

Hospital Admission
type: Class
subclass of: Hospitalization
subclass of: Healthcare Facility Admission
subclass of: Restriction
  some values from: Hospital
  on property: SIO_000061
comment: The event of admitting some patient into a hospital.

Invalid Test
type: Class
subclass of: Test
disjoint with: Valid Test

ICU Admission Not Requiring Tracheostomy
type: Class
type: QualityValue
type: NodeShape
subclass of: ICU Admission By Tracheostomy Status
subclass of: Class
  complement of: Restriction
    some values from: tracheostomy
    on property: SIO_000250
comment: An ICU Admission of a patient that does not require a tracheostomy immediately upon admission.
notation: 429
equivalent class: Class
  intersection of: ICU Admission
  intersection of: Class
    complement of: Restriction
      some values from: tracheostomy
      on property: SIO_000250
  equivalent class: ICU Admission Not Requiring Tracheostomy

plastic container
type: Class
type: NodeShape
subclass of: OBI_0000967
comment: Corresponds to FSTA Thesaurus Packaging 2.2.1 Plastic container.

Z-Score
type: Class
subclass of: Anthropometry
definition: A z-score (also known as z-value, standard score, or normal score) is a measure of the divergence of an individual experimental result from the most probable result, the mean. Z is expressed in terms of the number of standard deviations from the mean value.

microunits per milliliter
type: SIO_000074
notation: µU/mL

Fast Food Consumption Frequency
type: Class
type: QuantityVariable
subclass of: Diet Quantity
subclass of: SIO_001367
definition: Frequency of Fast Food Consumption.
was approved by: PER-Jeanette-Stingone

Specimen analyzed in singlicate for an assay that requires duplicates
type: Class
subclass of: SIO_001167

Finished Elementary Grade 4
type: Class
type: QualityValue
subclass of: Educational Status
notation: 116
definition: Finished grade 4

Maternal Weight Gain
type: Class
subclass of: Pregnancy Characteristic
subclass of: Weight
definition: The amount of weight gained during a pregnacy.
was approved by: PER-Jeanette-Stingone

Hospital
type: Class
subclass of: Healthcare Facility

ventilator-associated pneumonia
type: Class
subclass of: pneumonia
subclass of: hospital-acquired infection
subclass of: CAUTI or CLABSI or VAP

Valid Allergy Test
type: Class
type: QualityValue
subclass of: Valid Test
subclass of: Allergy Test
notation: 359
equivalent class: Class
  intersection of: Valid Test
  intersection of: Allergy Test
  equivalent class: Valid Allergy Test

ICU Admission By Tracheostomy Status
type: Class
type: QualityVariable
type: NodeShape
subclass of: Medical History
subclass of: ICU Admission
comment: A subclass of ICU Admission; it is used to differentiate between when patients require a tracheostomy upon ICU admission versus when they do not.

Genotype
type: Class
subclass of: Medical History

Chloroform
type: Class
subclass of: Volatile Organic Compound
notation: CFRM
definition: CHLOROFORM is a commonly used laboratory solvent. It was previously used as an anesthetic, but was banned from use in the U.S. due to its suspected carcinogenicity.

Fresh Vegetable Consumption Frequency
type: Class
type: QuantityVariable
subclass of: Diet Quantity
subclass of: SIO_001367
definition: Frequency of Fresh Vegetable Consumption.
was approved by: PER-Jeanette-Stingone

micrograms per meter cubed
type: SIO_000074
notation: µg/m3

Socioeconomic Status
type: Class
subclass of: StudyIndicator
definition: Socioeconomic Status Indicator Class
was approved by: PER-Jeanette-Stingone

Head of Household
label: Head Of Household
type: Class
subclass of: Demographic
subclass of: SIO_000016
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: Household
definition: The Person is the head of Household
definition: Head of Household is a filing status for individual United States taxpayers. To use the Head of Household filing status, a taxpayer must: (1) Be unmarried or considered unmarried at the end of the year (2) Have paid more than half the cost of keeping up a home for the tax year (either one's own home or the home of a qualifying parent) (3) Usually have a qualifying person who lived with the head in the home for more than half of the tax year unless the qualifying person is a dependent parent.
was approved by: PER-Jeanette-Stingone

Mercapturic acids of 1, 3-butadiene
type: Class
subclass of: Tobacco Metabolite
notation: HEMA

Electron Transfer Dissociation (ETD)
type: Class
subclass of: TandemMassSpectrometry

nutrition intake
type: Class
type: QualityVariable
subclass of: Diet and Nutrition
definition: Nutrition intake is the process of taking in of nutrients, especially by eating or drinking, considered in relation to the body’s dietary needs.

English Language
type: Class
type: QualityValue
subclass of: Acculturation
notation: 243
definition: The English Language

3-Chlorophenol
type: Class
subclass of: Environmental Phenol
notation: MCP3
definition: PHYSICAL DESCRIPTION: White crystals with an odor of phenol. Sinks in and slowly dissolves in water. (NTP, 1992)

Hispanic or Latino Ethnicity
type: Class
type: QualityValue
subclass of: Ethnicity
notation: 47
definition: A person of Cuban, Mexican, Puerto Rican, South or Central American, or other Spanish culture or origin, regardless of race. The term “Spanish origin” can also be used in addition to “Hispanic or Latino.”
was approved by: PER-Jeanette-Stingone

toxin
type: Class
subclass of: Thing

Cotinine
type: Class
subclass of: Tobacco Metabolite
notation: COT
definition: The N-glucuronide conjugate of cotinine is a major urinary metabolite of NICOTINE. It thus serves as a biomarker of exposure to tobacco SMOKING. It has CNS stimulating properties.

1 or 2 Years of College, Technical, or Vocational Training
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: Higher Education
notation: 313

Anatabine
type: Class
subclass of: Tobacco Metabolite
notation: ANAT

Allergy Test
type: Class
type: QualityVariable
subclass of: Physical And Mental Assessment
subclass of: Restriction
  some values from: Allergy
  on property: SIO_000563

Count in last 24 hours
type: SIO_000074

United States of America
type: QualityValue
notation: 184

Difference
type: Class
subclass of: SIO_000052
definition: Variables derived from taking the difference of two other variables. For example, the first difference of a time series {yt} is defined as Dyt = yt - yt-1

Haircare Product Use
type: Class
type: QualityValue
subclass of: Personal Product Use
notation: 30
was approved by: PER-Jeanette-Stingone

Element
type: Class
subclass of: Targeted Analyte

Patella
type: Class
subclass of: SIO_010046
definition: The patella, also known as the knee cap or kneepan, is the largest sesamoid bone in the human body. The primary functional role of the patella is knee extension. The patella has convergently evolved in placental mammals and birds; marsupials have only rudimentary, non-ossified patellae. In more primitive tetrapods, including living amphibians and reptiles, the muscle tendons from the upper leg are attached directly to the tibia, and the patella is not present. See also: fabella.

Technical Post-Middle School
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: High School or Less
subclass of: Technical School
notation: 94
definition: Attended a Technical Post-Middle School.
was approved by: PER-Jeanette-Stingone

Mercury
type: Class
subclass of: Metal
notation: Hg
definition: A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.

Abrasion
type: Class
type: QualityValue
subclass of: SIO_000475
notation: 387

micromolal
type: SIO_000074
notation: µmol/kg

Invasive Mechanical Ventilator Assisted Respiration
type: Class
type: NodeShape
subclass of: respiration
subclass of: artificial respiration
subclass of: Restriction
  some values from: invasive mechanical ventilation
  on property: SIO_000139
comment: Respiration that requires assistance from an invasive mechanical respirator.
disjoint with: Ventilator Free Respiration

3 or 4 Years of College, Technical, or Vocational Training
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: Higher Education
notation: 314

Valid Test
type: Class
subclass of: Test
disjoint with: Invalid Test

Ordinal Position
type: Class
subclass of: Thing

behavioral response to pain
type: Class
subclass of: SIO_000475

Diet and Nutrition
type: Class
subclass of: StudyIndicator
definition: Diet and Nutrition Indicator
was approved by: PER-Jeanette-Stingone

Gel Electrophoresis
type: Class
subclass of: SIO_001007
definition: Gel electrophoresis is a method for separation and analysis of macromolecules (DNA, RNA and proteins) and their fragments, based on their size and charge.

m-Xylene*
type: Class
subclass of: Volatile Organic Compound
notation: MXY
definition: M-xylene is a colorless watery liquid with a sweet odor. Less dense than water. Insoluble in water. Irritating vapor. (USCG, 1999)

Ever Smoked
type: Class
type: QualityValue
subclass of: Smoking Status
notation: 136
definition: The quality of having smoking in the past.
was approved by: PER-Jeanette-Stingone

Child
type: Class
subclass of: Descendant
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: Restriction
      on property: hasRole
      all values from: Parent
    intersection of: SIO_000485
definition: A relationship with a parent (such as sons and daughters of any age).
was approved by: PER-Jeanette-Stingone

Control Group
type: Class
type: QualityValue
subclass of: Population Group
notation: 200
definition: A group used as a standard of comparison in a control experiment.

72 kDa type IV collagenase
type: Class
subclass of: Protein
notation: MMP2

Functional Status Total Score Below 3
type: Class
type: QualityValue
subclass of: Functional Status Total Score
notation: 369

Drug Other Than Antimalarial Use
type: Class
subclass of: SIO_001398
subclass of: Pharmacotherapy
subclass of: Restriction
  some values from: drug other than antimalarial
  on property: SIO_000230
subclass of: Restriction
  some values from: SIO_000393
  on property: SIO_000291

Number of Members in Household
type: Class
type: NodeShape
subclass of: Demographic
subclass of: SIO_000794
subclass of: Restriction
  some values from: Household
  on property: SIO_000215
comment: The number of people living in a household

Asthma Diagnosis Group
type: Class
type: QualityValue
subclass of: Diagnosis Group
notation: 312

2,3-dinor-8-iso Prostaglandin F2 alpha
type: Class
subclass of: Targeted Analyte
notation: F2A23D

Sleep Characterisitic
type: Class
subclass of: StudyIndicator
definition: Sleep Characterisitics Indicator Class
was approved by: PER-Jeanette-Stingone

2-hydroxyphenanthrene
type: Class
subclass of: PAH
notation: PHEN2

Direct Mercury Analyzer
type: Class
subclass of: PhysicalInstrument
definition: Direct mercury analysis incorporates the following sequence: thermal decomposition, catalytic conversion, amalgamation, and atomic absorption spectrophotometry. Controlled heating stages are implemented to first dry and then thermally decompose a sample introduced into a quartz tube. A continuous flow of oxygen carries the decomposition products through a hot catalyst bed where halogens, nitrogen, and sulfur oxides are trapped. All mercury species are reduced to Hg(0) and are then carried along with reaction gases to a gold amalgamator where the mercury is selectively trapped. All nonmercury vapors and decomposition products are flushed from the system by the continuous flow of gas. The amalgamator is subsequently heated and releases all trapped mercury to the single-beam, fixed-wavelength atomic absorption spectrophotometer. Absorbance is measured at 253.7 nm as a function of mercury content
was approved by: PER-Jim-McCusker

Hydrogen–Deuterium Exchange Mass Spectrometer
type: Class
subclass of: Mass Spectrometer
definition: Hydrogen–deuterium exchange mass spectrometry can determine the overall deuterium content of molecules which have undergone H/D exchange. Because of the sample preparation required, it is typically considered to provide an accurate measurement of non-exchangeable hydrogen atoms only.
was approved by: PER-Jim-McCusker

Weight
type: Class
type: QuantityVariable
subclass of: Anthropometry
subclass of: SIO_000279
definition: The resulting Force from the interaction between a person's Mass and Gravity.
was approved by: PER-Jeanette-Stingone

DVD Player Count
type: Class
type: QuantityVariable
subclass of: Household Appliance Count
definition: Number of devices in the home that play DVDs.
was approved by: PER-Jeanette-Stingone

picomolal
type: SIO_000074
notation: pmolal

Waist
type: Class
subclass of: SIO_010046
definition: The waist is the part of the abdomen between the rib cage and hips. On people with slim bodies, the waist is the narrowest part of the torso.

Ozone
type: Class
subclass of: Environmental Exposure

Bedroom
type: Class
subclass of: room
definition: A room in a human dwelling that is the primary location where one or more occupants sleep.

Environmental Phenol
type: Class
subclass of: Targeted Analyte

Childhood Followup 3
type: Class
subclass of: Date of Birth
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: Childhood Period
definition: A point in a study that occurs after the second follow-up point in the study and occurs during the study subject's childhood period.

Some College Up To And Including Bachelors Degree
type: Class
type: NodeShape
subclass of: Higher Education

Short sample; sample probe picked up incomplete volume first time
type: Class
subclass of: SIO_001167

Dilution required
type: Class
subclass of: SIO_001167

Hospital Utilization
type: Class
subclass of: Healthcare Access
definition: Hospital Utilization
was approved by: PER-Jeanette-Stingone

Diet Treatment Medical Therapy
type: Class
type: QualityValue
subclass of: Medical Therapy Procedure
notation: 26
definition: Diet Treatment is a form of Medical Therapy.
was approved by: PER-Jeanette-Stingone

Technical Post Primary School
type: Class
type: QualityValue
subclass of: Educational Status
subclass of: High School or Less
subclass of: Technical School
notation: 95
definition: Attended a Technical Post Primary School
was approved by: PER-Jeanette-Stingone

nanomolal
type: SIO_000074
notation: nmolal

Test
type: Class
subclass of: AnalyticalMethod

Divorced
type: Class
type: QualityValue
subclass of: Unmarried
notation: 40
definition: Indicates a person whose marriage has been legally dissolved and has not remarried.

Long Range Polymerase Chain Reaction
type: Class
subclass of: Polymerase Chain Reaction
definition: Amplification of DNA lengths that cannot typically be amplified using routine PCR methods or reagents. For simple DNA templates, polymerases optimized for Long Range PCR can amplify up to 30 kb and beyond. For complex, genomic templates, 20 kb is a typical target.
was approved by: PER-Jim-McCusker

Eats Fish Sticks
type: Class
type: QualityValue
subclass of: Eating or Drinking
subclass of: Restriction
  some values from: FOODON_03311701
  on property: SIO_000369
notation: 225
definition: The attribute of eating fish sticks.

times per year
type: SIO_000074
type: SIO_000794
notation: times / year

Matrilysin
type: Class
subclass of: Protein
notation: MMP7

Adopted
type: Class
subclass of: Non-Biological Relative
definition: Adoption is a process whereby a person assumes the parenting of another, usually a child, from that person's biological or legal parent or parents, and, in so doing, permanently transfers all rights and responsibilities, along with filiation, from the biological parent or parents.

lux
type: SIO_000074
notation: lx

2, 2', 4, 4', 5, 6'-Hexabromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
notation: BDE154
editorial note: To Do: align with CHEBI.

microvolt
type: SIO_000074
notation: µV

Annual Income $15,001 to $30,000
type: Class
type: QualityValue
subclass of: Household Income
notation: 161
definition: Personal or family annual income bwtween $15,001 and $30,000

Diabetic Ketoacidosis
type: Class
type: QualityValue
subclass of: SIO_010056
notation: 391

Study Emergency Department
type: Class
type: NodeShape
subclass of: Emergency Medical Services Facility
subclass of: Study Location
comment: An emergency department in a hospital at which a study is being conducted

Moderately hemolyzed
type: Class
subclass of: SIO_001167

Stromelysin-2
type: Class
subclass of: Protein
notation: MMP10

monooxoisononyl phthalate (DiNP)
notation: MONP

Manganese
type: Class
subclass of: Metal
notation: Mn
definition: MANGANESE is a trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)

Titanium
type: Class
subclass of: Metal
notation: Ti
definition: TITANIUM is a dark-gray, metallic element of widespread distribution but occurring in small amounts; atomic number, 22; atomic weight, 47.90; symbol, Ti; specific gravity, 4.5; used for fixation of fractures. (Dorland, 28th ed)

2, 4, 6-Trichlorophenol
type: Class
subclass of: Environmental Phenol
notation: TCP246
definition: 2 4 6-Trichlorophenol is a synthetic, colorless crystalline solid that is slightly soluble in water and soluble in organic solvents. It has been used primarily in pesticide formulations and as a wood preservative, although most uses have been cancelled in the US. When heated to decomposition, 2, 4, 6-trichlorophenol emits toxic and corrosive fumes of hydrochloric acid and other toxic gases. Exposure of humans to 2, 4, 6-trichrophenol via inhalation has been reported to cause respiratory effects, altered pulmonary function and pulmonary lesions. It is reasonably anticipated to be a human carcinogen. (NCI05)

Separated
type: Class
type: QualityValue
subclass of: Married
notation: 41
definition: Indicates a person living apart from his/her spouse by legal arrangement.

Marital Status
type: Class
type: QualityVariable
subclass of: Tobacco Related Exposure
definition: A person's current conjugal status.
was approved by: PER-Jeanette-Stingone

Ancestor
type: Class
subclass of: Relative
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: Restriction
      on property: hasRole
      all values from: Descendant
    intersection of: SIO_000485
definition: An ancestor or forebear is a parent or (recursively) the parent of an ancestor (i.e., a grandparent, great-grandparent, great-great-grandparent, and so forth). Ancestor is "any person from whom one is descended. In law the person from whom an estate has been inherited."
was approved by: PER-Jeanette-Stingone

Eats Oily Fish
type: Class
type: QualityValue
subclass of: Eating or Drinking
subclass of: Restriction
  some values from: Oily Fish
  on property: SIO_000369
notation: 226
definition: The attribute of eating oily fish.

Retina
type: Class
subclass of: SIO_010003
definition: The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.

kilovolt
type: SIO_000074
notation: kV

2, 2', 4, 4', 5-Pentabromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
notation: BDE99
editorial note: To Do: align with CHEBI.

Annual Income $4,999 or Less
type: Class
type: QualityValue
type: NodeShape
subclass of: Annual Income $5,000 or Less
notation: 414

Monthly Income Less Than $416
type: Class
type: QualityValue
subclass of: Household Income
notation: 284

Annual Income $30,001 to $50,000
type: Class
type: QualityValue
subclass of: Annual Income $30,000 to $60,000
notation: 162
definition: Personal or family annual income bwtween $30,001 and $50,000

terabyte
type: SIO_000074
notation: TB

milligram per deciliter
type: SIO_000074
notation: mg/dl

Mitest not capped
type: Class
subclass of: SIO_001167

Do Not Resuscitate Order
type: Class
type: QualityValue
subclass of: Advance Directive
notation: 365

millivolt
type: SIO_000074
notation: mV

watt
type: SIO_000074
notation: watt

mono-2-ethyl-5-hydroxyhexyl terephthalate (DEHTP)
notation: MEHHTP

Chest tightness
type: Class
subclass of: wheezing or tightness in the chest or cough

Never Married
type: Class
type: QualityValue
subclass of: Unmarried
notation: 38
definition: Indicates a person who has never been married or whose marriages have been annulled.

Spanish Language
type: Class
type: QualityValue
subclass of: Acculturation
notation: 244
definition: The Spanish Language

DOID 1094
type: QualityValue
notation: 424

N-Ace-S- (3, 4-Dihidxybutl)-L-Cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCDHB
editorial note: To Do: align with CHEBI.

Eating or Drinking
type: Class
type: QualityVariable
subclass of: Diet Quantity
subclass of: nutrition intake
definition: The act of eating or drinking some food or beverage.

Light Bulb Count
type: Class
type: QuantityVariable
subclass of: SIO_000794
subclass of: Housing Characteristic
definition: Total Number of Lightbulbs in the Home
was approved by: PER-Jeanette-Stingone

2, 3, 5, 6-Tetrachlorophenol
type: Class
subclass of: Environmental Phenol
notation: TeCP2356
definition: PHYSICAL DESCRIPTION: Leaflets (from ligroin) or light beige powder. (NTP, 1992)

urinary tract infection
type: Class
subclass of: SIO_000475

2, 2', 4, 4', 5, 5'-Hexabromobiphenyl
type: Class
subclass of: Polybrominated Diphenyl Ether
notation: PBB153
editorial note: To Do: align with CHEBI.

3-hydroxybenzo[c]-phenanthrene
type: Class
subclass of: PAH
notation: BCP3

lumen
type: SIO_000074
notation: lm

Consumption Behavior
type: Class
type: QualityVariable
subclass of: Alcohol, Tobacco, and Illicit Drug Use

Asthma Controller Medication Prescription
type: Class
type: QualityVariable
subclass of: Prescription Medication and Dietary Supplements
subclass of: SIO_001398
definition: A subclass of medical intervention that characterizes a patient's receipt of asthma controller medication by prescription. It does not indicate if a patient has or has not received such medication or a prescription for such medication. These distinctions are made in the subclasses of this class.

Biological Sex
type: Class
type: QualityVariable
subclass of: Demographic

No FOL result; FOL = 8 ng/mL assumed
type: Class
subclass of: SIO_001167

Neptunium
type: Class
subclass of: Metal
notation: Np
definition: Neptunium. A radioactive element of the actinide metals family. NEPTUNIUM has the atomic symbol Np, atomic number 93, and atomic weight 237.

pneumonia
type: Class
type: QualityValue
subclass of: lung disease
notation: 195

Operating Room
type: Class
type: QualityValue
subclass of: Destination
notation: 171
definition: A room in a health care facility equipped for the performance of surgical operations and procedures.

Interleukin-22
type: Class
subclass of: Protein
notation: IL22

Widowed
type: Class
type: QualityValue
subclass of: Unmarried
notation: 39
definition: Indicates a person who is no longer married because of the death of his/her spouse and has not remarried.

N-Ace-S-(2-Hydroxyethyl)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCHEM
editorial note: To Do: align with CHEBI.

Limit of Detection
type: Class
subclass of: Concentration
definition: The lowest quantity of a substance that can be distinguished from the absence of that substance (a blank value) with a stated confidence level (generally 99%). The detection limit is estimated from the mean of the blank, the standard deviation of the blank and some confidence factor. Another consideration that affects the detection limit is the accuracy of the model used to predict concentration from the raw analytical signal.

3-hydroxychrysene
type: Class
subclass of: PAH
notation: CHRY3

Has Received Asthma Controller Medication
type: Class
type: QualityValue
subclass of: Asthma Controller Medication Prescription
notation: 283

Eats Rice
type: Class
type: QualityValue
subclass of: Eating or Drinking
subclass of: Restriction
  some values from: FOODON_03301641
  on property: SIO_000369
notation: 224
definition: The attribute of eating rice.

2, 2', 4, 4', 5, 5'-Hexabromodiphenyl ether
type: Class
subclass of: Polybrominated Diphenyl Ether
notation: BDE153
editorial note: To Do: align with CHEBI.

cells per milliliter
type: SIO_000074
notation: cells per ml

Hospital Admission From Study Emergency Department
type: Class
type: QualityValue
type: NodeShape
subclass of: Hospital Admission By Admission Source
comment: An admission from an emergency department into a hospital where a clinical study is being conducted, and the subject admitted is participating in the study.
notation: 435
disjoint with: Hospital Admission Not From Study Emergency Department

Neighborhood Characteristic
type: Class
subclass of: StudyIndicator
definition: Neighborhood Characteristic Indicator Class
was approved by: PER-Jeanette-Stingone

Plutonium
type: Class
subclass of: Metal
notation: Pu
definition: Plutonium. A naturally radioactive element of the actinide metals series. It has the atomic symbol Pu, atomic number 94, and atomic weight 242. Plutonium is used as a nuclear fuel, to produce radioisotopes for research, in radionuclide batteries for pacemakers, and as the agent of fission in nuclear weapons.

Malaria
type: Class
type: QualityValue
subclass of: Disease
notation: 121
definition: A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle.

parasites per microgram
type: SIO_000074
notation: parasites/µL

megakaryocyte-erythroid progenitor cell

N-A-S-(3-hydrxprpl-1-metl)-L-cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCPMM
editorial note: To Do: align with CHEBI.

Quit Smoking Before Pregnancy
type: Class
type: QualityValue
subclass of: Quit Smoking
subclass of: Pregnancy Characteristic
subclass of: Prenatal Nonsmoker
notation: 81
definition: A Previous Smoker who Quit Smoking Before Pregnancy

Annual Income More Than $100,000
type: Class
type: QualityValue
subclass of: Annual Income More Than $95,000
notation: 223

Intelligence Quotient
type: Class
type: QuantityVariable
subclass of: SIO_000052
subclass of: Physical And Mental Assessment
definition: A measure of intelligence
was approved by: PER-Jeanette-Stingone

HHEAR Ontology v1.6
imports: teamworkconstraints
imports: core
imports: graphql
type: Vocabulary
type: Ontology
default namespace: http://purl.org/twc/
status: UnderDevelopmentStatus
comment: The Human Health Exposure Analysis Resource (HHEAR) measures exposures that cover the breadth of the “exposome,” which encompasses all environmental exposures including chemical, physical, and biological stressors, as well as lifestyle and social environments, from conception through adulthood. Read more at: https://hhearprogram.org
root class: Thing
version IRI: http://purl.org/twc/HHEAR/1.6
subject area: HHEAR Ontology
subject matter expert: bengos01
subject matter expert: stingj01

1-hydroxybenzo[c]-phenanthrene
type: Class
subclass of: PAH
notation: BCP1

Omalizumab (Xolair)
type: Class
subclass of: Asthma Controller Medication

millimole per liter
type: SIO_000074
notation: mmol/L

Specimen analyzed with less than usual dilution
type: Class
subclass of: SIO_001167

Polychlorobiphenyl
type: Class
subclass of: Organochlorine Compound

Study Site
type: QualityVariable
definition: A facility in which study/protocol activities are conducted. [def-source: NCI]

Married
type: Class
type: QualityValue
subclass of: Marital Status
notation: 37
definition: Indicates a person currently joined in a legally binding matrimonial union. Classify common law marriage as married. Includes married couples living together and not living together.

Zafirlukast (Accolate)
type: Class
subclass of: Asthma Controller Medication

micromole per liter
type: SIO_000074
notation: µmol/L

N-Ac-S-(2-Hydrxy-3-butnyl)-L-Cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCMB2
editorial note: To Do: align with CHEBI.

katal per liter
type: SIO_000074
notation: kat/l

Landfill Proximity
type: Class
type: QuantityVariable
subclass of: Environmental Exposure
subclass of: SIO_000041
definition: How close a household is to a landfill.
was approved by: PER-Jeanette-Stingone

2-hydroxybenzo[c]-phenanthrene
type: Class
subclass of: PAH
notation: BCP2

Difference of Weight-to-Length Z-Scores from 0 to 6 Months
type: Class
type: QualityVariable
subclass of: Difference of Z-Scores
definition: The arithmetic difference between the weight-to-length Z-scores for a child taken at birth and at six months.

milligram per gram
type: SIO_000074
notation: mg/g

Specimen analyzed with less than normal quantity
type: Class
subclass of: SIO_001167

katal per cubic meter
type: SIO_000074
notation: kat/m3

Childhood Followup 2
type: Class
subclass of: SIO_000417
subclass of: Study Followup
subclass of: Restriction
  on property: inRelationTo
  all values from: Class
    intersection of: Childhood Period
definition: A point in a study that occurs after the initial follow-up point in the study and occurs during the study subject's childhood period.

Medical Leave
type: Class
type: QualityValue
subclass of: Occupation
notation: 246

Breath

Measurement
type: Class
type: QualityVariable
subclass of: Physical And Mental Assessment

Health Maintenance Organization Insurance
type: Class
type: QualityValue
subclass of: Insurance
notation: 49

arachidonic acid
type: Class
subclass of: Fatty Acid
notation: C204N6
definition: A long-chain fatty acid that is a C20, polyunsaturated fatty acid having four (Z)-double bonds at positions 5, 8, 11 and 14.

Hydroxycotinine
label: Hydroxycotinine (total)
type: Class
subclass of: Tobacco Metabolite
notation: HCOTT
notation: HCOT

High Performance Liquid Chromatography - Tandem Mass Spectrometer
type: Class
subclass of: Liquid Chromatography - Tandem Mass Spectrometer
subclass of: High-Performance Liquid Chromatography-Mass Spectrometry
definition: Liquid chromatography and tandem Mass Spectrometry. MS/MS (Tandem MS) is the combination of two mass analyzers in one mass spec instrument.
was approved by: PER-Jim-McCusker

Mono-n-pentyl phthalate
type: Class
subclass of: Phthalate
notation: MPP
editorial note: Duplicate of mPeP?

milliliter per liter
type: SIO_000074
notation: ml/l

Annual Income $30,000 to $49,999
type: Class
type: QualityValue
subclass of: Annual Income $30,000 to $60,000
notation: 221

In Vitro Fertilization
type: Class
type: QualityValue
subclass of: Assisted Reproductive Therapy
notation: 50

Microplate Reader
type: Class
subclass of: PhysicalInstrument
definition: Instruments which are used to detect biological, chemical or physical events of samples in microtiter plates. They are widely used in research, drug discovery, bioassay validation, quality control and manufacturing processes in the pharmaceutical and biotechnological industry and academic organizations. Sample reactions can be assayed in 6-1536 well format microtiter plates. The most common microplate format used in academic research laboratories or clinical diagnostic laboratories is 96-well (8 by 12 matrix) with a typical reaction volume between 100 and 200 µL per well. Higher density microplates (384- or 1536-well microplates) are typically used for screening applications, when throughput (number of samples per day processed) and assay cost per sample become critical parameters, with a typical assay volume between 5 and 50 µL per well. Common detection modes for microplate assays are absorbance, fluorescence intensity, luminescence, time-resolved fluorescence, and fluorescence polarization.
was approved by: PER-Jim-McCusker

mono-2-ethyl-5- carboxypentyl terephthalate (DEHTP)
notation: MECPTP

Surface-Induced Dissociation (SID)
type: Class
subclass of: TandemMassSpectrometry

Body Mass Index
type: Class
type: QuantityVariable
subclass of: SIO_000052
subclass of: Anthropometry
subclass of: Class
  intersection of: Restriction
    some values from: Height
    on property: wasDerivedFrom
  intersection of: Restriction
    some values from: SIO_000279
    on property: wasDerivedFrom
definition: A measurement relating body weight to height in an organism; typically calculated as the weight of an individual divided by the height of that individual squared. For quadrupeds, the square of body height is often replaced by the square of body length
was approved by: PER-Jeanette-Stingone
editorial note: Should we note that this is derived from height and weight? JS: I think so

Hepatic failure
type: Class
type: QualityValue
subclass of: SIO_010056
notation: 395

artery disease
type: Class
subclass of: Disease

Quit Smoking After Pregnancy
type: Class
type: QualityValue
subclass of: Quit Smoking
subclass of: Prenatal Smoker
subclass of: Pregnancy Characteristic
notation: 80
definition: Quit Smoking After Pregnancy

Nornicotine
type: Class
subclass of: Tobacco Metabolite
notation: NORN

N-A-S-(1-HydrxMet)-2-Prpn)-L-Cys(ng/mL)
type: Class
subclass of: Volatile Organic Compound
notation: VOCMB1
editorial note: To Do: align with CHEBI.

milliliter per cubic meter
type: SIO_000074
notation: ml/m3

Insurance
type: Class
type: QualityVariable
subclass of: Socioeconomic Status
subclass of: Healthcare Access

1-hydroxybenz[a]anthacene
type: Class
subclass of: PAH
notation: BAA1
editorial note: Only found in one journal article, no where else. Maybe mis-spelled?

Medical History
type: Class
subclass of: StudyIndicator
definition: Medical History Indicator Class
was approved by: PER-Jeanette-Stingone

Annual Income $50,000 to $99,999
type: Class
type: QualityValue
subclass of: Household Income
notation: 222

million parts per microgram
type: SIO_000074
notation: x106 µL

Study Baseline
type: Class
subclass of: SIO_000417
definition: Point in study set to initial point.

Niobium
type: Class
subclass of: Metal
notation: Nb
definition: Niobium. A metal element atomic number 41, atomic weight 92.906, symbol Nb. (From Dorland, 28th ed)

Autism Spectrum Disorder related condition
type: Class
type: QualityValue
subclass of: Developmental Disorder of Mental Health
notation: 150
definition: Quality refers to children who do not meet DSM criteria for ASD but have scores on ADOS and Mullens that suggest related outcome. All potential options seems to fall under this class from the Autism Ontology

experimentally modified cell in vitro
type: Class
subclass of: Cell

mono benzyl phthalate (BzBP)
type: Class
subclass of: Phthalate
notation: MBP

Leptin
type: Class
subclass of: Protein
subclass of: Metabolite
definition: Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways.

max exclusive: 25.0

Datatype
with restrictions:
  min exclusive: 29.9
on datatype: float

Datatype
intersection of: Datatype
  with restrictions:
    min exclusive: 25.0
  on datatype: float
intersection of: Datatype
  with restrictions:
    max exclusive: 29.9
  on datatype: float

rest: nil
first:
  max exclusive: 25

max exclusive: 15

rest: nil
first:
  min exclusive: 18.5

min inclusive: 15

Restriction
on property: SIO_000300
all values from: Datatype
  with restrictions:
    min exclusive: 25
  on datatype: integer

min exclusive: 25.0

rest: nil
first:
  max exclusive: 25.0

Datatype
with restrictions:
  max exclusive: 18.5
on datatype: float